Chemicals Identified in Human Biological Media, a Data Base: Third Annual Report, October 1981, Volume III, Part 2 (Record Numbers 3501-5271)

Co Chemicals Identified In Human Biological Media, A Data Base Third Annual Report October 1981 Volume III Part 2 ------- EPA 560/5-81-008A ORNL/EIS-163/V3-P2 CHEMICALS IDENTIFIED IN HUMAN BIOLOGICAL MEDIA, A DATA BASE Third Annual Report, October 1981 Volume III, Part 2 Records 3501-5271 Compiled by M. Virginia Cone, Margaret F. Baldauf, and Fay M. Martin Chemical Effects Information Center Information Center Complex Information Division OAK RIDGE NATIONAL LABORATORY Oak Ridge, Tennessee 37830 operated by UNION CARBIDE CORPORATION for the DEPARTMENT OF ENERGY Contract No. W-7405-eng-26 This effort was accomplished under the aegis of the Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, National Institutes of Health, Chairperson, Dr. Herman F. Kraybill. Date Published — December 1981 Cindy Stroup, Project Officer Design and Development Branch Exposure Evaluation Division Office of Toxic Substances U.S. Environmental Protection Agency Washington, D.C. 20460 ------- CONTENTS Part 1 Acknowledgments v Introduction . ^ Users' Guide 3 Abbreviations for Analytical Methods 7 References for Data Base 9 References for Physical and Chemical Data 51 Appendix A. Journals Searched 55 Appendix B. Chemicals in Data Base (1979-1981) by CAS Preferred Names 59 Appendix C. Chemicals (1981) by CAS Registry Numbers and Preferred Names 83 Appendix D. Cross-Referenced Chemical Lists 103 1. CAS Preferred Names — Common Names 105 2. Common Names — CAS Preferred Names 141 Appendix E. Tissues and Body Fluids in Data Base (1979-1981) 325 Indices 329 Author Corporate Author Tissue Keyword ............................ 367 Directory of Chemicals (1981) .................. 377 CAS Pref Formulas CAS Preferred Names ...................... 379 090 Part 2 Data Base Nondrugs ........................... -, Drugs ..................... ........ 345 iii ------- NONDRUGS ------- Icctaldehyde 75-C7-0 CS-M-0 !« M.05. IP -123.5 C, BP 20.8 C TISSUE 3501 Blood 3502 Blood 3503 Ereath 3584 Ereath EIEOSOBE BOUT! Inhalation Xngestion AIALTTICAL BETHOD SC GC/!!S CC-IS IUHEEB OF CASES 4 8 54 (387 samples) IAIGE a] 0.403-0. 593110 (E-3) 1» 0.545-0.847110(8-3) a) 5.015-16.387 ag/«l b) 9.160-11.050 ug/»l Hot detected-79. 0 ug/hr Hot given HSAI \| 1 I a) 0.494M10(E-3) \| b) 0.6611I10(E-3) \| 1 1 I 1 a) 10.41 + or - 3.76 uq/ml b) 12.88 + or - 3.31 22.7 ug/hr 3.3 ng/1 oeoietric GUIEiL IIFORBATIOI a) Mo trickloroe thy lens treatnent t) 100 ppi trichloroethylene Banqe and lean foe 6 hr period 20-26 vr old students, wt 62-77 kg. CE1CRIMTID BTDFOCABBOHS; ALCOHOLIC EIVMACBS: BIOOD: BLOOD PLASBA; OSIII: BETABOLITES; BETABOLISB; AUDITS; SEBSJHT --- - a) After 0.5 q/k ------- Icetic acia ethyl eater H1-78-* C(-68-02 Bl 88. Id, BF -83,6 C, BP 77.15 C, T? 100 II 3g at 27.0 C iissnz 3505 E«ath 3506 Enath _ ZIEOSOBE goal minicii RETROD SC/BS SC-SS irasEts or c»sss 8 5« (337 saiplas) f SJfSE I lot detected- 1«l»TICH: BETIEOLISB; BII1BOUTES: ( PCPOllTICH ElPOSOSBi JBBlll »IiS 1 _ . BEFES5SCE Contla, J.3-. CaBpr B.J. telch, E. E. 1»75 irdilTes of iDnicouectal Bejlth 30 CJ) =290-395 EiotaszjDStl, B. K. BcaBeao, G. 9. C'Keill. H.J. 1979 Coacnal of Aaalrtical Tolicologi 1:225-234 tcttlc acil. allrl «« (9 CD Icetic atria. 2-prapeirl est«r (3 CI) "1-8T-7 CJ-B8-02 t IOfl.13. SP 10« C I 1ISS01 1 3507 treat! titosats scan lutmcit GC--TS 1 imsss 1 Of (USES 5t [387 sai pies) I IKE Rot fire* BEil 0.296 ng/l Geometric GEIIB1L 1»F05BJTIO» naaued at 25 C at 3 7iO ai B? Jtf . T occurrence l<:»er a»J upper one-Sign limits 0,0»3 aid 0.435 nq/1 BeaItkT< T9-35 rr old, coosioHlxr, •Ttan blacks aid caocasiais. Chicago. II. Bigiflly contiolled expcriaentBl condltiois. tll»9; 1ICOG01S; IILI1IOIS; IDHITS; CEiCRimirn trosociseois; TOUTIIE CS01.1IC COBKWDS; BULTB BlZ>BIS: HBIHTICII-. BETISOHSB: BETIBOUTBS: ICPOLlTIOfl riPOSOil; tllBiS IEEIS EEFEE29CE FTOtOEZfESlli, 3. K. C'«eill^ B^jJ 1979 Journal at lealrtical Toiicology 3:225-230 ------- ic«tic acid, butyl ester 1S3-8«-« C6-B12-02 B« 116.16. BF 126 C. TP IS •• Bq at 25 C iissns 3503 Heath 3509 Breath ErPOSBBE FOOT! IHlTTICAl flETBOB GC/BS GC-BS JDlEla OF C1SSS 8 5» (387 Maples) EMGE Hot givea-41.0 ag/hc lot given BEM \| GtlEHL IHT08HTIOS 1 1 9.1 ug/hr (Ccatound related to aoraal I tetabolisi. So other details given \|C cyoqenic saiplinq technique. 1 inealthr illitairy and civilian- (eiployees. U.S. tic Force school of \| Aerospace Beaicine, ages 23-47 yr. 3 jsioters. 1 \|MSZE«ES; CBIOP.IMTED BTDBOCH.BOHS; \|C FLOS HE OBGHIC COBPOOSDS; ICH10BOBEHZIIIS; FIOOBISE COHPOIUDS: IEHI1TH; llCCHOLS; TEIAS; 1DU1TS 1 \| 0.200 ng/1 \| teasuced at 25 C and 760 la Bq Seoaetric , I 30. «t occurrence 1 lover aid upper one-Sigaa lliits 1 0,055 and 0.139 nq/1 IBcalthy, 18-35 yr old, nonsaofcinq. I Chicago, II. Bigidly controlled I )EB!»TH: tlCOGOlS; I III SOI S; IDOLTS : \| CItOBI!HTE5 ETDBOC»BBO»S; VOI»TI1E \| CTGIHIC CODECOHDS; RZkLTB SUZiRCS; II1B1UTICK: SETiEOLISn; HET1E01ITSS: \| FOPHL1TIOII IIPOSOBS! OSB»H 1BE1S BEFERERCE Ccnle. J.P. Caap, B.J. Kelch, S.E. 1975 Irchives of Environaental Health 30(21:290-295 Krotoszynski, B. K. Craneaa, G. H. O'Neill, B.J. 1979 Journal of Analytical Toxicology 3:225-23* Icetic acid, octyl ester 112-1H-1 C10-B20-02 If 172.27, BE -38.S C, BP 210 C tissue 3510 Ereath SIEOSOHE ROUT! »»»trric»i BETHOD GC-SS 808 EES OT C1SSS 5» (387 Saaples) HUGE Rot given SEkl \| GEH'BAL INFC5SXTTC* ! 0. 168 ng/1 I Xasarei at 25 C and 760 >a Rg Geometric \|«.U occurrence t lever and upper one-sigaa liiits \|0.0»2 and 0.679 nd/1 1 (Bealthy, 18-35 yr old, nonsmoking. I urtan blacks and Caucasians. (Chicago, II. BiqidlT controlled jeiperiieatal conditions. (BBS4TH: HCCHOIS; IlimOIS; M91TS: \|CB108I!HTEB FIDBOC1BBOSS; ?Ol»TIL! ICBGMIC C09PCDHDS: BEAITH BIZSSDS; \| IIHIHTICH; 8ET1EOLIS9; BF.TKOLITE5: \| PCPOL1TIOI EIPOSOBE; D5BAS AFEAS 1 BEFEBERCE I rrotoszjnski, B. K. Brtinean, G.B. O'Seill, H.J. 1979 Journal of Analytical Toxicology 3:225-23« ------- Icetic acid, phenyl- (8 ell Eexzeneacetic acid (9 CI) 103-82-2 CE-B8-02 BS 136.1«, BE 76.7 C, BP 265.5 C, T? 1 •• Rq at 97.0 C tISSOE 3511 Breath EXFOSDBE BOOT! 1S1IITIC11 HETBCD QC-BS HOHBEB OP C1SBS 54 [387 sag pies) HUGE Vot given SE«» 0. 161 ng/1 Geoietric S!IIE»L MKJSaaTJOH Eeasnred at 25 C and 760 11 BS 161.2, HI 276 C, BP 227 C I1SSBE 3512 Breat IIFOSD55 ROOTE HJLItlCH SETHcn 5C-BS SOBBFE or cisEs 5* (387 sanp es) BIISE Hot given K»J 0.115 ng/1 CltlSll IirOBUTIOl feasared at 25 c and 7CO » Eg Ic«er and apper one-Sigia Units 0.038 and 0.3«9 og/1 Bealthy, 19-35 yr old, nonsmoking* nrtao blacks and Caucasians. Chicago, It. eigidly controlled cxperinental conditions. tBIJTB; JICCBOIS; IltlHOIS; «DDLTS; CBI05IMTED EIDROCIEEOBS ; V011TILE CFG1M1C COICCDIDS; RI4ITH BiZlBUS; IIHlItTICN; BEIJtOLISS; HEI1EO11TES; ICPDLITIOH flPOSDPE; 1BBJLB IBEJS 1 SEFESEHCE KIoto«,S£Xi, M. C'Keill^ B. J. 1979 Toxicology 3:225-23» tcctic acid, propTl ester 1C9-60-> C5-B10-02 II 102.13, HP -92.5 C, BP 101.6 C, »P 10 In tig at 23.8 C 1ISSOE 3S1J Exeath 1 IFOSOE; BOTIIE SfTBOB \| GC/SS I 1 OF C1SSS 8 I 1 SJKGE Hot detected-2.0 ug/hr HEX 0.5 ug/hr GEHBJL IWFO«31TIO> Ccipound related to norial •etabolisn. Ho other details given Cryogenic sampling technique. Sealthy military and civilian eiployees. U.S. lir Force School of Aerospace nedicine, ages 23-il'7 yr. 3 siokers. IISIME5: CBICBIHITIB HTDBCC1BBOSS; CG10SIHE OESinC COBPOnKDS; CElCBOBSlimtS; FLDCTHE COaPOUKDS ; ISinH; XICCBO^S; THIS; ITBITS BEfERBKCS Cockle, J.P. Canp, B.J. Delch, B. E. 197S Archives of Environnental Health 30(21:290-295 ------- Icetic acid, propyl ester 1C9-60-4 CE-B10-02 BS 102.13, (!E -92.5 C, BP 101.6 C. It 40 •« Hg at 28.8 C (COITIROZD) 1ISSOB 3514 Breath ZT.POSOBE BOUT! AUITTICAI BETHOD GC-BS HOBBIB OF CJSSS 54 (387 sai pies) BHGE Not given BEi« 2.» ng/1 Geometric GEH5AL IKFOBBATIOH Measured at 25 C and 760 •• Eg 49.4* occurrence letter and upper one-sigaa liaits 1.1 ana 5.2 nq/1 Healthy* 18-35 yr old, nonsioking, acfcan blacks and Caucasians. Chicago, II. Rigidly contcolled ISEITH; A1CCBOLS; ILLIHOIS; ADULTS ; CELOBIHATEC BTDEOCA5EOSS; TOHTIl! CEGtlTC COHECH!IDS: BE1LTH BI2JECS; HB«liTIOI(: BETJEOLISS: BETASOLITES; ECPmtTIOl EIPOSaBE; HBBAH IBEtS SEFEBEHCE Krotoszyoski, B. K. Braneaa, G. H. O'Seill, B. J. 1979 Journal of Analytical Toiicology 3:225-231 cetic acid, thio- (8 CI> thanethioic acid (9 CD 07-09-5 :-H»-O-S « 76.11. HP <-17 C, 3? 93 C, TP 1 » Hg at 50.0 C USSOE 3515 Breath EIPOSUBI BOOTE KltTTICtl. BETBOD GC-BS KOBBES 0? C4SSS 5» (387 saiples) B»KGE lot given 1 MEtS 3.7 ng/1 Geoietric GEHEE1L IBF08B1TIOH ecasured at 25 C and 760 n H ------- Icetlc acid, trichloro- 7«-03-9 CI-B-C13-02 St 163.t3. If 57-58 C, Sf 1»-197 C (COMTITOBD) 1 TISSD1 I ~ 3517 Brine EJfOSOBt ROOM IWITlcre BETBOD Inhalation EC BOSSIS or cisss s 1 1 1 1 i 3518 1 fhotoaetrr 1 2117 Brins 1 1 1 1 1 1 1 I 1 sitai a; 99-5 mg b) 5-65 119 ' - less than t->500 mq/l BUB 1 GEXIEIL IfFOBBaTXOB 1 BEFE5EICZ 1 f 1 I a) Hot alien I a) Day 5 and 17 of 50 PP« b) Sot gi»en 1 tricaloroettrlene. 6 iir/dar, on 5 \| cctioecati»e days. Initial Talae, 20 1 4 an day 1 1 t) 1 and 1« dars after 50 ppl 1 tricblaroetbfleoe, 6 tr/a«r, on 5 1 conseeatiie dars. plus etkanol 1 pretrejtaett. Final raloe, 7 aq on I d.T 1« I 2* br excretions 1 latinated frcm orapb. 1 1 20-26 T? old students, t €2-77 kg. 1 1 CBtOBIBlTri BTDIOCUBOIS: IICOBOLIC I BiHBKis; Biooi; Bicor PI.ISBI: 1 OBHE; BBHB01ITIS: BITIBOIISIf: I ICOtTS; seism 1 1 •ot ?irea I Jfter erposare to trjcfiloroethrJene j [at also qiTen for age- and I sei-specific aactalitr tram aeopltsms \| nd total icrtalitr >s coipared «ith I portalitr of Finnish population. 1 I Iges V5-65 rx or aorc. 1 \| riBUBt; JDDIIS; OEISE; COBPIS1TITI \| CIIIOITIOBS; CHLOBIIIS CBGJUIC \| CCBICHIDS ; IJCffSTBIH 1TBOSPHFBES; 1 Bailer, G. SpassavsXi, B. Benschler, D. 1975 Irchives of Toxicology 33:173-189 Tola, S. Tllhanen, B. Jfttvinen, E. KorSala, a. 19BO Jqoinil of Occupational BeSicine 22 (It) : 737-700 t oc Icctoacetic acid. b«trl ester (9 CD Eatanoic acid, 3-oxo-« fcutTl ester \|9 CI) 5S1-60-* 1«S. 20, BE -3S.6 C, DP ussai 35t» Bceata I IIKtSOBI SO9TI AIlltlJCAI BET9CD GC-BE BOBEeB or cjsss S« (387 salples) J1FEB lot givea »!i» I or»fsn ijrrosaifior t i I 0.192 tj/1 [ fejsnrej at 25 C aad 760 >i B? S«oiettic 1 19.1V occocrence 1 lover ana eppec aoe-Sigma liiits 1 0.059 as a O.€13 aq/1 ( 1 SealthT, 18-35 re old, nonsiofcinq, ( attta clactf and Caucasians. 1 Chicago. II. SiqidlT contcollea 1 «iperi>egtal cocdttions. 1 I ISUTH: HCCEOir; TIUSOIS; MH1IS; ICELCftllkTII ETDPOC1SBORS; 1011TILE 1 CIG1B1C COJPCU1DS; BEaLTB «IZ15tS; 1 IHILITIOIt BIT4E01IS1; HIT4EOLITE5; f eCTULttlOl EinsniE; DEBill IBI1S L lire sires FrotosjTDEki, 3. IT. Euneau^ S.9. C'seill, E.J. 1971! Toiicologj 3:225-23* ------- lc«tOM 18 Cl) 2-PtOBaiOM (9 CI) «7-««-1 C3-I6-0 81 58.08. IP -9«.« C. BP 56.«8 C. fP «00 •• Ba at 39.5 C 1ISSOB 3520 EE«ltk 3S21 Breath 3522 Breath . 3523 Breath EZFOSOBE mrai - alllTTIClL BRIOB OC/HS GC/BS GC-HS GC inaeia or c»sss - 13 8 5« (387 saaples) a) 5 b) 5 IllGE 0.22-4.87 pps 1.3-2000.0 ng/hr lot given a) lot given b) lot given RIM 0.52 ppn 500.6 ag/ir 101.3 ogA Seaietric a) 309.0 * or - 3.1 nioleVl b\| 20.3 * or - 3.1 moles/1 entni. nroiiiTioi comctea fci level it inhaled aic EealtkT alalt> siBDBi; loitis: ansinzBZii BRBODS; IIIBHOl Ccipoma related to noiaal ntabolisi. lo other details givea Ccyoganic saepliag techaigne. Bealthy ailitary and clTilUn eiplorees. O.S. llr Toroe School of leco^paec Heaicine, ages 23-47 jr. 3 tickers. EIKIIBS; CBIOBIItlH BIBBOC1BBOIS; CBLOBIII OBGIIXC COBPOOIDS; CBtOSOBIIZEIIS; FL001UE COBFOniDS; EBIITB: IICCEOLS; TZXIS; 1D01TS «ea«Eed at 25 C and 7CO •• flg lOOf occurrence lewc and upper one-Siqu liaits 5«. 6 aid 181.7 gg/1 Bealtkr* 18-35 Tt old, nonsiokiag. oxfcaa blacks and Caucasians. Chicago, It. RigidlT controlled eiperiaental conUtiona. tIEITS: HCCEOIS; I1IIIOIS; ID HITS; CElOBIllIir BTDEOCIBBOIS; fOUTILE cioiiic coipomiDS: HHITH H»I»BDS; IlHlIiTICl; BETIEOLIS8; HZHBOLITBS; ECPU11TIOI IIPOSOSE; Visit SBIIS a) Snblects taking 250 ag/day tulfiraa b\| Controls Significant increase (P < 0.001) la drag-treated subjects. lea-fasting sablccts. ages 25-«a jr. taking dicalfiran for treatneat of alcoholisa fee 1-7 so. (ornal. ion-fasting controls, ages 20-55 re. [BOG TUtlPT; Hf»ESOTa: » DOITS; INKS BiniBlCI Jansson, B.o. larsson, B.I. 1969 Journal of Laboratory and Clinical Bethods 7« (6) -.961-9(6 Conkle, I.P. Canp, B.J. Reich, B.I. 1975 archives of Environmental Bealth 30(2):290-29S Rrotoszvnski, B. K. Braneaa, 6.1. d'leill. B.J. 1979 Journal of Inalytical Toxicology 3:225-23* DeHaster, E.G. Kagasva, B.T. 1977 Research Coaannicatioas in Caeiical Pathology and Pharaacology 18(2):3C1-36« ------- icetonitril* 7«-«S-8 C5-B3-I SI 41.05. IF -45 C, IF 81.1 C. TP 100 •• Bg It 27 C TISSUJ 3524 Breatt ZIPOSOBJ BOBIB iiiinicaL HIT BOB 6C-BS IBBBra OT C1SE9 54 (387 sanplea) I1IGI lot jiie« BUI 7.4 ng/1 Seonetrle GIHMl motlallOl tcanrcd at 25 C and 7«0 nn Bq 19.4* oecnirence I»»er and upper one-sigsa Units 3.0 and 16.0 ng/1 IMltny. 18-35 re old, nonsnokinq, oi Ian blacks and Caucasians. Cklcago, ii. Eloidlr controlled «ip€rlnentnl conditions. ItZITB; klCOeOLS; IILIIOIS: UILTS: CElOBUlTfO BTDlOClBBOIS; JOlaTIlE CES1IIC CQBPCUIDS; HltlTB BlllSrS- IiaiLlTIOI; HttlBOIISH; «BT»BOIITIS! ECPVL1TIOI HPOSOBB: HUH 1EEIS itmssct rcotoszmski, 8.K. Brnnenn, S.s. c-it«ill, a.J. 1979 Journal of analftical Toxicalogr 3:225-23* , dlchloro- (8 CI) aictloro- (9 CI) 7«72-29-» CJ-C12 If S4.9t, IF -«6 to -C«.2 C 3525 Sreatli nrracB oc-as or ctsis 54 (387 saaples) lot jirca •si" i eimii itroxBiiioi i 10.6 nq/i \| Beasarel at 25 C and 760 an Ea Seonetric \| tf.»» occerence t Io»er and npper one-sioia liaits 2.8 1 and 41.9 Dq/1 1 1 lcm. 18-35 1C old, oonanoJtlK,. 1 irtan blacks and Caucasians. 1 Chicago, n. Bidiilr-controlled 1 eipcrlnental conditions. 1 HIITR: 1ICOEOLS; IILIIOIS: 1BB1IS: 1 CELOKIMTH BT080CJB9OIS: TOlaTIlE J CIBMIC COBPTOIDS; BMIIB giZlBES; ( II»LaTIO«; HCTIEOLISB; BII1BOLITIS- 1 EC?011TIO» EIPOS08B; OBB»» 1BB1S BlFEBtfCI rcotasTTnskl, «.)!. Bmnenn, G. 8. O'leiii, H.J. 1979 Journal of analytical Toiicolo^r 3:225-234 ------- llaaiaa, 3-lMthTltkle}-, t- (8 CI) l-CTtOla«. S-MtbTl- (9 CI) 1187-8-* c-i9-t-o2-s II 13.20 1ISSOI 3126 oriaa BI tost is BOWK Inhalation iiiinicii BETBOD CC •oaazi or cisss a) b) c) d) n 91 7 IIIGI a) 100-475 aaol b) 200-425 aaol c) 25-90 aaol d) 175-415 aaol •) 20-675 uol f) 40-150 aaol all are /aol ereatlalae - - nil a) 336 BBOl b) 30 aaol c) 38 aaol 4) 289 aaol e) SI 2 aaol f) 72 aaol «) «S » or - 23 aaol 111 aM /aol creatinino GIIE111 IBPOIB1TICI a) Bethyl ckloride aiposue, 30-70 KB b) Retkyl cklorido exposure, 30-50 KB c) Mtkyl eklorida oapoaan, 40-40 EFB d) flctkyl cklorido oapoaaro, 40-70 a) Sotkrl eklorida exposure. 35-65 Fpa f) Batkyl ckloride azpoaar«. 50-90 q) coatrcl laaple* taken 2X/day 7 days Ckaalcal plaat vorkera IITIEKIIIOS; 1DOLTS; VIIBE: 1E1LTR Biiisos; innsniu MBOSPBIBES; IIBU1TIOI; IET1801IIES; CBIOIIIITED BItBOC>B«OI5 1 BEtEBEICE Tan Doom, B. Bora, P.J.I. Benderaoa. P.I. Beavara. J. Tan Borgia, T. J. 1980 International IrckiTaa of Occapational and EBTironaeBtal Bealtk 46:99-109 llaaln, 3-l«-C-kT4ro>r-3-lodopbaaoxr1-3.5-Uloaopaanrl\|-. 1- 18 CH l-Trroaia«, e-(»-kTroiy-3-lo4ojko»Tl)-3.S-411odo- (9 CI) CEU-02-3 C15-812-13-1-0* II tS1.01. tt 236-237 C (lac) IlSSflt 352T Blood, tlKSVVS JOOTt iiitmciL HCTHOD III •VIBZS or cisss a) 23 h) 42 O 27 d) 22 »MS a) 80-250 aoytOO al b) 273->1»Ofl no/100 al c) < 36-145 og/100 al d) 174-410 (0/100 al BE1I a) 183 B4/100 al b) lot giTBB e) lot jlTon d) 275 aq/100 al GIIHU IirOSBlIIOI a) CatkTtold Tolastoora b) Hypoctkrcold patioata c) HTpotkTTCld pattoata 4) Boraal, proqaant mien Halt of dotactloa, 36 nq/100 al iciBoiis; iiisoiBmt BRBODS; BLOOD SIBOS: TIMS (ETEBEICB BtOBl I.I. BotkeaBT> •>• 197* Joaxaal of Pkaraacoatical Sclencea 63 («): 1214-1217 IllTl aleokel (8 CI) 2-Itoiwa-l-ol (9 CI) 107-18-6 C--86-0 » 58.08, » -SO C. BP 96-97 C. TP 10 aa fq at 10.S C 1ISSOB 3528 tiaath EXtoson mm tin men BETBOD ec/ns inan or cisss 8 11TCI «ot d«t«et«d-9.S ui/kt •Ell 1.3 no/kx etiitii iBroiBinoi Ccipoaad relatad to aozaal •otabollaa. lo otkoc detailt 9lTa Cryogoalc aaapllai tockuiqne. ••altkr ailltarr and elTilian «aplOTMl. D.S. lie force School of Icrospaea n«liclo«, aq«s 23-47 TT. 3 aaokeca. EllZNCS; CIIOBIBKED BTDIOC1BBOIS; CBIOBIII oieinc coipomnis: CBtomiBiziKS: FIIOBIIS coamms; IBIHI; 11CCBOLS: TZMS: HOHS IEIBIEICS coakl. i.e. Caap, S.J. ••lek, I.E. 197S IrekiTca of EBTiroaautal Boaltk 30(21:290-295 ------- linings 729-90-5 11 lt» 2«.98151, » «60 C, BP 2327 C. TP 1 •• Ig at 150 C : TISSai EIPOSSSI ROOT! lorta 1 1 3 5 JO 51004, sera a 31 rod. 2 1 1 f 1 1 1 1 1 1 1 1 1ULTTIC1L BETBCD 11 US 1 t us 115 I OH BIB OF C1SBS 2 1 a) « b\| 69 c) 23 U f« It 30 :J 57 1) 3g E1IGS 8.5-20 ag/s [net vt) a) lot applicable b> lot applicable c> lot applicable d) lot applicable a) Vot given b) Sot given c) lot given >t lot giTei >) lot given :J lot given [\| lot given BUI 11 » or - 8 I Hodge, K.C. desCerrioranine I 1^80 d! Final leasareaant, dar 290 I lancet 2<8196) :692-693 Levels sLoaed sbort-teca cyclic 1 •artatlags, and long-tera opvard 1 trend luting treataent. E3tiaated t (cos grapb. 1 36 Tr old aen vitV dialysis \| encephslopatbv. \| 1 Irileptlc seizures, svoclonlc larks, I CialTsis eaceptalopatkr, 1 etteodvstrachv, prosisal aiopatliT. 1 1 noiiim; i»troos STSTEB OISEISZS; I BiTODiiiisis: anus; DSITID KIIGQCB: t EtOCD SEBHI \| i 1 a) controls I Gilli, t. b) Drenic patients on besodlalrsis. I Farlnelli, 1. Elalrsate. 7.7 * or - 7.51 og/1. pH \| Fagiali, I. 7.3 I DeBastlani, P. c) TIretic patients on internittent I Rnoncristiani, 0. rerltoneal dlalrsls. Dlalrsate, 10.07 I 1480 « or - 5.3 ag/1, pa < 5.5 \| lancet 2(8197) sT»J-7»3 >IDIET DI SEISES; 1LOHI»DB; IRltS; I HCOB SEltll; ITIII: BIBOD111ISIS t 1 t i\| Control: fron U.S. I llfroy, i.e. t) loalialTZcd patients 1 Regg. 1. c) DialTT«d patients I Crasvell, p. encepItalopatliT t Inerican Journal of 1 Clinical nutrition Orealc patients in U.S. and 1 33:1509-1516 Instralia. Sose died of dialysis I msTmti: limit STITES: nno?siEs: i IIIOIET OISIISES; 1EETOIS STSTIB \| CTStlStS; BOIES; BBlT-f; 8E1BI; LITER; 1 uses; losciis; S?LIEI: EEBCDIILISIS: i ItC Slim: HE11LS \| 1 ------- llCliniB II Itl 26.981S4. -IP 660 C. BT 2327 C, T? 1 •• Hg at 150 C (COBTIigSD) 1ISSQB 3533 Sralo 3534 Praia 3135 Bair 3536 Hair EXFOSDSE BOOTS iiittncu BETHOD 11 US ItllBES or CISES a) 16 b) 30 c) 57 d) 38 - a) 42 b) 40 llBSS a) 8.0-19 gg/g (rat vt) b) 22-23 ug/g (vet vt) c) 6.9- 15 gg/g (vet vt) d) 12-22 ag/g (vet vt) a) lot given b) lot given c) lot given d) lot given a) 1-17 ag/g b) <1-29 ag/g (HIT Bill a) 15 » or - 4 «g/g (vet vt) b) 23 » or - 1 ag/g (vet vt) c) 11 or - 2 ag/g (vet vt) d) 15 » or - 5 ng/g (vet vt) a) 2.4 * or - 1.3 b) 4.1 * or - 1.7 no /kg c) 8.5 » or - 3.5 •q/kg d) 24.5 « or - 9.9 •I/kg Defatted saeples ») 5 ug/g b) 5 ng/g ledians ?HS!) GE1IB11 IIFOSHMIC1 a) Bales, eerebree, 9 sabjects t) Teeales. eerebmn. 2 sabjects c) Bales, cerebellum, 6 snblects i) Tenales, cerebellua, S subjects Tron a groat of 61 autopsies. forensic nedical eianinations, Japan. Bales, nean age 40.6 rr. Feiales, nean age 37.4 vr. T11CI niBtllS; 10TOPSIZS; JIPII; iioBiinB: iBSERic; CIDBIUB; COBALT; etBCain.: COFPZB: MOB; BSBCUBT: IIBIUB; BlGICSIUfl: BA1611ESB: IOBIDIOB: iniBoit; sciiDing; siLEBioB; Timim: TiiioioB; zinc; GCLC; BBOBIII; lITEli KT91ITS; CIBEBBH1; CtEIBEHTIB; H!1BT: [HJSCLES; FHCB11S; SPXEEp; 1I1GS; lOBll; BITH.S: coipiBHTirs ETiLomcas: SEX; rcBEisic BICJCHI a) Controls fron O.s. r) londialvxed patients c) Dialrxed patients d) Bialried patients vith encephalofathf Oreele patients in O.S. and lastralla. Sone died of dialysis encepbalofattT. lOSIDlLII: 01ITED STITIS; 10TOPSIES: II It BIT 9ISE1SES; HIBTO03 SIS1EB CISI1SIS: BCBES; BB11J: BEIBT: LITEB; IBISS; IDSCltS; SPlItiT; RlilODIllTSIS; 1IBBI1H!!; BEIU.S leviev. 24 representative cte-aaalyis treataents are tabulated. Ibe feasibility of a bclistie, no-vash policy for bair analysis is cut lined and supported. ftTIEv; TP1C! riMEITTS; BUB; mSTfiH.lt; atlSO«EBEIT NETBOOS; gitus: pBoums; COBPIBITITE IISEIIC: B»BKIS; BBOIIIE; ClCTlm; cucin-i; cHicEiiE: CBBOHIIIB: COMIT; CCPPH: SIIH0B: sEBBtnvi; eoiD: icon!: IBOI: iiiTHiinB: lilt: BI61ESI»; BU61I2S1; BEBCDBI; tClTB9E!TJB: HCKtl: PBOSPHCBOS; iciisstvii: BUBIDIOB; snumB; SIUC01: SIIVB5; SODIVB; SIBCIIIIB; tlic: ilacoiion a) Controls c) Boltitle sclerosis patients Saaples fren 7 scalp sites in each •vc^ect. CI11B1; 1E01IS: CEITBll BtBVCOS !TSTZ9 DIS'JSES; 3»IB: KIDBIBU!!; IlCHIIt; C1ICIOB: CB10BIBE: COPPER; ecu: Km!: >iiisiiis:; IESILS; S1I»«11!; SIITEl; SCDIOH; SOIF3B; 71110131; TIIC BEIBBEBCE Tvkava, B. snzaki-Iasaaoto, B. leaao, 1C. Terai, B. 1980 1 retires of Enrironnental Health 35(1):3«-44 • Alfrey, I.e. Heqg, 1. crasvell, P. 1980 laerican Journal of clinical latritioa 33: 1^09-1516 cbittleboroagh, G. 1980 Science of the Total Environment 14:53-75 Byan, D.E. Bolzbecher, J. Stuart, D.C. 1978 Clinical Chemistry 24(11):1996-2000 ------- II mi cai 7g29.90-5 II Its 26.98154. HP 660 C. BP 2327 C. 7P 1 •• Ha, at 1590 C (COITIIOBD) 1I3SOS 3537 Beart 3538 Mart 3539 Kidney BIPOStJBS BOOtS atunxcii IRBOD U 1>3 U BOMBS 0? CISBS a) 4 b) 2 a) 16 b) 30 c) 57 4) 38 a) 6 b) 2 sues a) 4.7-26 ug/g (net «t) b) 23-34 a«/9 (oet «t\| a) Hot given b) lot given c) lot given d) lot given a) 10-41 ag/g (net »t) b) 12-12 ag/g (net lit) flEIT •Ell 16 » or - 9 ug/g (««t •t» b) 29 or - 8 ag/g («et »t\| a) 1.0 * or - 0.8 eg/kg b) 6.9 » or - 10.6 ag/kg c) 22.5 » or - 20.5 aq/kg d) 42.7 « or - 22.9 •g/kg Defatted saaples a) 20 » or - 11 og/g (vet »tj bj 12 * or - 0 ag/g (vet «t) PIGB) GEIIBll nPOBUTXCB a) Hales 1} resales tcoi a <\|coap of 61 autopsies. forensic aedlcal examinations, Japan. Bales, aaan age 40.6 ft- Females, •ean age 37.4 vr. 1B1CB EI.BBZBIS: 40TOPSIBS; J1P1S; iioBUns; iBsziic; CIDUOB; COBILT; CEBOSTBB; CCPPBB; IBOB; HEBCOBI; IltlOH; IfaGBZSIVB; UBeiBBSB; BOEIDIOHl IBIIBOBT; SCaBDIOB; SntBIOIt; TIIMIOI; TABIDIDI; ZIBC; «cit; BBOHUi; tirra; KIDIBTS; C1BBBBOB; ClBEBniOH: HB1BT; BOSC1BS; SIICBBU: SPIEM; LOK3S: 10BT1; BRILS; COBPUMIV8 BVilOHIOSS; SSI; fCBJISIC BiriCIBI a) control! tiow 0. S. t) Bondlalyiei patients c) olalysed patients d) Halted patients >ith •acephalopatby Dteiie patients in O.S. and lastralla. Sone died of dialysis encephalopatfey. losnuii: omsD SHTBS: IVTOPSIBS; HC8BI DISBISBS; IBBVOOS STSIBH tlSHSBS! BOIES; BEIIH; BElBTt 117 IB: loses! nosciis; SPLBB>; BBBODIIITSIS; 11CBIBHB; BB1US a) Bales t) reiales fron a gtonp of 61 autopsies. forensic ledical exaainationa, Japan. Bales, aean age 40.6 yr. Feaales. aean age 37.4 yr. 1D1CE BLBHIITS; IOTOPSIBS; JlPH; HOnBDR; IBSIHICJ CiDBIOB; COB1LT; CEBO»IUR; CCPPBB; IBOB; BBBCOBTj 1BIIOS; BaGIESIUB; BalGaBSSE; fnEIDMB; IBIIHOBT; SCaHDIOB; milTOH: TT1MIOR; T1BIDIOB; ZIBC; CCtll: 9BOHIBE; LIVES: KIOIETS; CIBZBBOB; CBBIBELUJB: BE1BT; HOSCISS: fllCBBIS: SflEBB; LOBSS; JOBTi: BITUS: COBPUtTITB BTAIOATICHS; SEX; PCBBKStC HIEICIHE BBFBBBVCB Tnkava, B. Suzaki-Tasanoto, B. Isano, R. Terai. B. 1980 archives of Bnvlronaental Health 3S(1):36-i)4 alfrey, I.e. Regg, 1. Crasvell, P. 1980 liecican Joornal of Clinical Bntrition 33:1509-1516 Tnkava. B. Sazaki-Tasaooto. n. liana. E. Terai. B. 1980 archives of Environaental Health 35(1): 36-40 ------- llaelaas T«29-90-S II Itl 2C.9S15I. It CCO C. If 2327 C. ft 1 M Ba It ISM C (CORIIOED) 1XS39I 350 llvor 351 352 Lviq 353 Lung NCOSOIS 1OOT1 1I11TCZCAL BCTBOD •1 us •1 us IBBBM or CISBS a) 9 b) 3 a) 1« b) 30 4 57 d) 38 a) 2 b) 2 a) 16 b) 30 d 57 d) 38 B1KB a) 10-25 ag/g (vet t) b) 5.5-20 ag/g (vet vt) a) lot given b) lot given c) lot given d) lot given a) 18-100 ig/g (wt vt) b) 10-23 ag/g (vet vt) a) lot given b) lot given c) lot given d) lot given RZ1B a) 18 or - 6 ag/g (vet vt) b) 15 * or - 7 »g/g (vet vt) a) ».1 » or - 1.7 b) 25.5 « or - 33.1 agAg c\| K1 * or - 12* ng/kg 1) 301 « or - 21* Defatted saaples a) 59 » or - 58 ag/g \|v«t vtj b) 17 » or - 9 ag/g fvet vt) a) »3 » or - »3 ag/kg b) 75.2 » or - 77.3 •g/kg c) 89.5 * or - 76.8 1) 215 « or - 220 ng/kg Defatted sanplea. SEIIIll XBFOIBHIOB a) Bales Iron a groap of 61 aatopsias. forensic nodical •xaninatlons. Japan. Bales, aeaa age «0.6 jr. fesales. seen age 37.1 yr. IBICB xiSBsns: IOTOPSISS; JIPIB; llOBIRvB; IBSniC; C10RIOS; COBUT: CBICRina; COPM1; IIOI; HBBCVBT; HtlDB; SISIISIOH: R1IG1IISB; inEIDIHI; 1ITIROBT: SCIIDIOR; SHEim; TITIIIOR; TIHDIUB: Hie; eciB: Btoiiit: um: KDESTS: CIBZBBM: ciBZBEiuiR: BEIBI; HOSCLES; E11CBI1S: SPtBBB; LOBGS; 1CR1; IRUS; COflPUlTIVB ByilDlTIOBS; SSX; ICIIISIC BKICIIB a) Coatrols froa U.S. t\| loaaialyxed patleats c) tlalyzed patioats 4) Blalysed catiaats a 1th eieepkalopatby flrenic patleits la O.S. and laatralia. Soae diad of dialysis eaeepbalopatby. llSnilll; OUTID STIIIS; lOTOtSIBS; If DIET BISB1SB5: RSTOOS STSTBR t is lists: BOIES; mil; BBIBT; iirsi: IDIGS: Rosens; SPLIE: HHOtimsis; I10IIIOR; H1111S a) Rales 1) Teaales froa a groap of 61 autopsies. forensic aeUcal oxaaliationa, Japan. I tics, lean ago 0.6 yr. Peaales. aeaa age 37.* yr. T11CB BIBBBItS: 10TOPSXZS; JlPHi iioniins; IBSZIIC; CIDRXDR; COBUT; cc ------- ilmlm 7«S»-«0-5 11 Itl 26.9815», at 660 C, BP 2337 C, TP 1 •• Bg at 15W C (OOVTIBBXD) IISSBE EirosotE BOWB IBUTIICU BETBOD 35«» Ba BaBcte 1 1 j 3515 Basel* 1 US I f 1 1 1 1 1 1 t 35« u BttBBSJ or ctsss 1 b] a ) i« 1 30 ) 57 1 38 1115! \| 1 \| a\| 8.3-16 gg/g («et >t\| 1 a\| 13 b) 7.4-29 «g/g (Mt >t\| 1 (rat 1 b) 17 1 (et 1 f 1 1 1 1 1 r i i i i i a] lot gtrea I a) 1.2 b) lot livei \| 11/tg ) tot glrea I 6) 2.S ) Bot given \| eg/kg I e) 9.1 1 ag/ltg 1 d) 1«.S t e?/'Jt? BE1B \| SHIIlt moiBHXCI 1 1 1 + or - 3 ug/g f a) Bales vt) 1 II Tevalev + or - 7 ug/j t vt) 1 fro i ?rc«f of 61 autopsies. 1 fcreaslc aedlcal exaaiaationa, Japa f aa2av tutt a^e 40. C fr* faaalea. I aeaa a Ualraed patleats 1 d) Clalned patieata vlth « or - 14.6 \| encephalopatbr 1 * or - 13.7 \| Create patients la (r. 3. aad ; Joetralia. So»e died of dial/aix I 1 1 llfrei. I.e. 1 B«gg. 1. 1 crasrell, f. I 1980 1 laerlcan Journal o i clinical (otcitioa 1 33:1509-1516 i t I Defatted sanples eaccpfcalopatlf. 1 1 t 1 1 5 1 a} 9.3-30 nq/q fust vt> la] 15 * Pancreas 1 1 t) 2 I b) 18-25 «g/g (vet vl) I (ret «t) 1 II »> 22 * I f«at vl) i 1 1 1 insTBiLii; nme STITIS; JBTOPSISS,- Kinzr DISUSES: IZBTOOS SHTEB CISUS'3; BOIES: BBalf; 1Z1IT; UTJB; I1BGS; BOSCLIS: SPLEII; HSlOIIlltSIS; lIOBinB; BE1J1S or - 9 pj/9 1 •' Bales \| t) Teaales or - 5 ag/g 1 f tram a graft o- 61 autopsies. \| Coreaslc avdical eiTaaiaatioar, Japan. 1 Bales, swan ag* 0. € rr. Peial«8. I aeaa ag« 37. TC, 1 ( SMC* nlBEBIS; ItlTOPSIES; J1T1I; \| IIUBIITB: ItSEBIC; CaDBIOB; COBllT; \| CESCflll': CCFPBB; IBOJ; REBCOEIi \| IBDIH!I; IlCBZSItIB; B1BS1BZSI; \| SOBIDITI; linBOIT; SC1IDHJB; \| SUHI11; Tinting; fl I1BIOII; ZIIC; t fiCID: BBOBIBI; I.ITEE; XTOIETS: \| CltEBRlH: CIBtBEUOB; BSlIf; BVSCLXS; I >1ICIB»: SPIXE: lOKS; lOSTl; \| BIT11S: COBPU1TITE CTILD1TIC1S; SIX; \| fCIIISIC HICICIII \| t 1 t 1 1 1 I 1 1 Tokava, B. t Sazakl-Tasaaoto, I. 1 laaao, t. 1 lerai, B. 1 "BO 1 IrctUes of 1 lOTlronaental Bealth 1 35(1):36-«« 1 1 t t I f 1 t 1 1 \| 1 (Btlt PtGt) ------- 7129-90-5 II Itl 26.4115. W 660 C. BP 2327 C, fp 1 aa Hg at 1540 C nssai 3547 Splem 358 Spleen Exiosns icon alUTXICU IR10B u us BOBBIE or CISES •I s b) 3 ' a) 16 b) 30 0 57 1) 38 1 11ISI a) 6.7-25 ag/g (««t «t) I) 16-»4 ag/g («et it) a) lot gi»«i b) nt gl»«« O lot gifB d) lot gi»« RIM a) 14 + oc - 8 ng/9 (net lit) b) 26 * or - 16 J/g (»«t rtl a) 2.6 » or - 2.1 •i/kg b) 35.3 01 - 72.3 •9A9 C) 2»3 » or - 250 aqAg 3) 493 • or - 463 •9 A? Mfattcd saiplaa CtllllL IlTOlSUIOH •} lain t) f«Ml«S Txoi a gcovp of 61 attopsics. fot«»lc aeileal axaaiaatloia, Japan. Bales. Ma> «g« «0.6 yr- r«aleB. •a> «g« 37.4 TT. »ici ncims: IBTOPSIIS; juu; ittnna; iismc; cutiva: COBILT; CtBCSIBS; CCPPHJ I10PJ B1JCUI1; IICIH«; laSIISIOB; nlURESI: »UBiT)in»; ininont; scuoira; itiinaHi TiiuiDi: TIHD«B: zinc; CCID: BBOBIItS HTBB: KIDBITS: CIBBBBCI; citniiiaa: BEIBI: susais; EUCBZI3; spun: IDKSJ ICBI; BITUS; COIIPUHin ETJLniTIOIS: SXI; TCBIISIC KBICIIX a\| Controls flroi 0. s. t) tmtitlmS patl«nts e) ui»lri«a fatluts d) DlalT>td patltnti «lth •accpaalopatkT Ircslc patients ta U.S. asd Usttalla. Sow di«d of dialysis •aecpaalopatkT. lostBiui: miTED STiTis; inapsiss; IIC1EI DISUSES; niTOOS STSTI9 rijzisis: BOIES: BIHI; min; IITBB; inss: aosciis; SFIIBI: BEBODIIIISIS; iitniw; units BIIEIEVCE Takava, B. SoiaKi-Tasnioto, a. liana. It. T«al. B. 180 Archives of tSTllonieBtal Baalth 35 (1(: 36- 44 tlfMT. »-C. B^g, i. Ctasvell. ?. 1980 laericaa Joarnal of Cliaical Bntritton 33:1509-1516 1318-09-8 IIKT CODPOSmoi USR1IOII CB DIBBTMBIIBB nssnB 3541 latastlie ZXtOSOBZ BOOt! Ingest Ion MHTTICH nrrncn tn BOSSES or ciszs a) 21 b) 32 IIIGE a) lot glT«o b) lot girtn •an a) 0 b) 3.20110(1-5) flb«u/g Ish «t ?fe SHIBII HfOBBlTICK a) Controls t) Kesldeiits witb 1014 ten, high l«tal exposnu fcoi drinking ccataainat«d «at«r \|gtopsl«s, Jflonoa wall !!2-89 Tr old rasldeats neat t&conite Ftocessin? plant, niaatsatt. 17-77 jr tld controls, IHnnesota and Texas. eilBESOTl; THIS; aOTOFSIES; IBIESIIBES; IITEE; lOISS; DBIIUnS ««!•>; HtdSnitl EBISSIOIS; IBOH5TBIU EC11DTIOB; (aTEB EC1LDII01: ISBISTOS - BETEBEKCE Carter, B.E. larlor, B.r. 19SO Environmental Besearch 21:85-93 (IEI1 ?JGE) ------- latklboles 13 10-0«-e mc» COSPOSITIOI oinon 01 mtirninra iissiiB 3550 tine 3551 law BirOSOBB lOOtl laaectiaa Iag«stion 1 i 1 1 1IU.TTIC11 HB9BC& N Bl •(mm or CISBS •1 30 b) 32 UTCB a) tat givea b) tot glvea a) lot aim b) lot gin BUI 1 etIIMl ZtrOBMTIOl 1 I a) 0.3«I10(l-5) \| » coatrola flbers/g 1 b) lesideats «itk long tera. hivk bt S.KIIO(B-S) I 1««1 ««a»n lea* IrUkiij fibers/? \| ccnt«iii«t«ii «t«r tk t I Ktopdw 1 t i2-n rr eld nsil«its i«r tacanlt I F'oc««aiiq pl«t, linMCota. 1777 yr 1 cltf coitrali, Rin«ot« aid Texas. 1 1 eiinsori: Tizist umrsus; t itTismis; irrii; luics; onntiie i inn; iimntxii mssiois: I IIEOSTMII EO.IDTJOI: HTIi I icunioi: tmsios i 1 a) O.SUtOtI-5) I I) Controls fibers/9 1 t) lesUeit* «itk lo>« tera. blah b) 16.21110(1-5) I level exponce free drlaxiif fibers/g 1 ceataaiaated natex ish »t \| lotopaiea 1 I S2-89 ji old resideata neat taeeaite 1 ftocessiag rlaat, liaaeaota. 17-77 rr 1 eld coatrolSp ffiaaesota aad Texas. 1 1 HIIESOT1; IZIISi 10TOPSIBS; I miSTIIIS; UTZI; tDTCS; DBIHtCTS 1 ntn: itDisniii insstots; I iievsniit tctmiiot: MTBI 1 ICIIOTIOI: J5HSTOS i IBRIBICI Carter* B.E. Tirlor, t.r. 190 BBvlroaaeatal Reaearcb 21:85-93 1 1 1 Carter, B.E. \| Saflor^ W.F. i 180 Earlroaaeatal Beaearca 21:85-93 00 IrlllM, •.••-•etkrleebia(2-ealaro- (8 Cl) I«neaasine, a,«'-a«UTleoebIsf2-chloro- (9 CI) 101-ta-a C13-B1Z-C12-H If 267.2 I IIS301 1 1 1 3552 1 Oriae 1 BIfOSVK! B0«r laaalatloa Penal 1 tinmen I IBTVOD i 1 Coloriictrr •maEx or cuss 1 tires i 0.0«-3.8 a«/l \| IE1I tot giTea etiiui iiroiuTioi lir coneeatratloBS oalr sliahtl; above tkrestold of detectioa (0.01 >«/c< e) . Iiposed icriers. lev Jersey CCCOMTIOI1I BHiUS; OBIIE; CBlOBItE CISIBIC cotrcnos: BstsmBUR fKIOnS: UCBSTKIU ReiBII tETEBnCX liack, I.I. 1S7« laericaa ladastrial HTgieae IssociatioB JoatMl 3S:26-«32 ------- intisony 1«40-36-0 st Itl 121.75, n C30 C, B? 163J C. IP 1 •• 19 at 866 C. 10 •• Bq at 960 USStJB 3553 lorta 355 Brain 3555 Bale BIPOSOJE BOOTE 1BUITICU. BBTBOD Bl Bl •OBBSS OF CUSS 3 B1B6B lot given a) Bot given b) Bone detected (IEIT BBaB 0.01 » or - 0.02 ng/g (net »t) a) 0.01 « or - 0.02 •g/g («et «t) b) Bone detected PISE) GZBEttl IBPOBSITIOB Bales iron n grosp of 61 autopsies. forensic medical exaninations, Japan. Bales, sean age 40.6 yr. resales. i«an age 37. a yr. II1CI ILEHEBTS; JUTOfSIES; J1P1B; JIUBIBUB; JBSBIIC; CIDRIUfl: COB JIT; CBSOaXVB; COPPEB; I BOB; BBBCOST; IICI01; BlGBtSIDH; B1B61IZSE; 1B8IDI05; IBtXBOBT; 9C1BDXBB; jiiBBiuB; TITJBIOB: YIBIDIOS: znc; GC1C; IKOBIlIi LITEB; KIDBETS; C!BBBBB!l; CZBISEUBB; BE1S1; BOSCLBS; FIBCBZIS; SPIEEI; IIBGS; 1OBT1; BIT US; COBf J11TITB ET1L01TIOIS; SEX; KIIBSIC B1DICIBI a) Tesales, cerebrvn, a subjects t) resales, cerebellns, 4 sab-fects Tton a groa; of 61 autopsies. forensic sedical exasinations, Japan. Bales, seas age ao.6 yr. resales. •ean age 37.* yr. TBICE EtlRBIISi 1VTOPSIBS; J1P1B; ItBBXBOB; 1BSEBIC; C1DBIHB; COBUT; CEBCBIHB: CCPPEB; XBOB; BEBCOBX; IBCItIB; BlGltSIOB; BlBGiBBSE; IVEIDIOB; IBIIROBT; SCUDIOH; SE1BBXUH; TII1BIOB; T1R1DIOB; ZIBC; ecic: BsoaxiE; LITBB: KXDIETS; CBfBBlVB; CBBtBELLUB; RB1BT; BVSC1B5; PIBCBB1S; SPIRB; IDICS: JOBT1; •IIILS: COBP1B1TITB BT1LD1IICBS; SIX; TCBIBSXC REEICXBZ It vie. 2» lepreseatative pie-analysis treatments are tatnlated. The feasibility of a >«listic, no-«ash policy for hair analysis is outlined and supported. IfTIZB; TB1CI IIBBEBTS; HUB; inSTBUIl; BEISOBBIBBT BET BODS; EITILS; PBOT1IIS; COBP191TITB IY1L01TIOIS: 110BIIOB; JSTIBCBT; USHIC: EJRIDB; BBOIIBB: CJDBIDB: CHCI01; CBICBUB; CB30BIOB; CO E JIT: CCPPEB; GI11.I1J!!; GEBB1IIOB; SOID; ICDIBB; laCB; 11BTR1IBB; lElt; IIGIZSIHB: BiBOtitsE: BEBCVBT; BCITBDIBOB; IICKIL; SBOSPHCBOS; fciissitji; tDBioioR; SIIEBIDB: SIIICOB; SIITBS; SODIHH; STBOBTIUH; SVIPOB: TIB; TITHIOB: TOBGSTEB; E1BC; ZIBCOUOB IZPZBIBCB Tokaia, B. Sazvki-Tasnsoto, B. Isano, K. Teral, B. 15-80 Irchives of ZnTironmeatal Bealth Tokava, B. Snzoki-Xasasoto, H. Inano, K. Terai, B. 1930 Irchives of Enviroasental Bealth Chlttlebocoagh, 6. 1980 Science of the Total Environnent It: 5 3-75 ------- ;«10-36-0 St l« 1J1.75, RP 630 C. BP 1«3« C, TP 1 an 89 at BS« C. 10 us 89 at 960 (COBTUOED) TISSUE 3556 Bale _— . 3557 Heart 3558 Kidney STPOSflSH BOOTH iBimreii iWBOB B» B . SnaSBB 0? CaSBS a) 10 b) » a) 22 b) 3 SiBOE . _ a) Dot given b) lot given - a) lot given b\| Hot given BBXB .. a) 0.01 •» or - 0.02 «a/g (»e* *l b) 0.02 or - 0.02 aq/q («et «t) a) 0.01 t or - 0.03 B9/g (»et »t) b) 0.01 * oc - 0.02 aq/g (vet vt) G!BFB»l IHFOBiiTIOH 1 revie» of >orld lltetatnre on to« accnivlBtioti an« blocoDCeotietion of selected to tic trace netals ill bnaai hair and mils aafl other nansaHin baicr fact nails* clavs and boofs. labaiatai by geographic area. •abjeete. «ei» «qe. axpasate 9£adieotr analytics in ppa* and anthocity frqn ovec 000 E«tenaces. tr«ICt; inSlBslUl CUaDat CIHltM. IHIBICIt BOiCPE; HIttDLE BJSt: Ht» niiMDt sooia aBEnict; somnist • Sla; OHITII KIveDOI: OBHED STSTBS; BUB; JJIIS! BEYICT; ABTIBOBT; is3tmc; BO BOS: caoiimi: CBHOFntms ccfitT; COPPIB; IBID: BBBCOBI: IICFEI; S?lS!lI13nj TIB; TiSADIDH; ilE FCllBTIOB; IBIBil POP014IICI3: IIOaCCDIOimOVi BIOIBDICMOIIS; t»«B tOtlOTIOS; POPOHTICB EtPOSOBB; RlTtR FC11DTTOH; TB1CE BLBRBRSt BETalS - a) Bales t) F«Mles FCOl t qtaap of 61 autopsies. fatensie asflical exaainatlons. Japan. Bales* a«ao age 40.6 ji, Feaales* lean »q« 37. 4 yr. TB1CE 8189EI1S; JTITOP3IBS; J1PM: llOBIIIOilt S8SESIC; CUDBIDB; CD E JIT; CFSC8HJB; COPPBB; ISO!); BEBCOBYJ IltlDX; BaGBISIOB; BtBGaBISl: JCSIBIHI; UTISOBY; SCIHOlOM; SIllBIOH; TI11RIOBS TaBtDIOB; ZTBC; ecin: BBOHUB: LIT BE i KIDBKIS; CIBIKtQK; CISEBEHOn; H5ABT; BVSCLES; PIBCSB»S: SPIES; LDVGS; ACBTI; StTlIS: COIPJBiTIVS B7iL0JT30BS; S2X; fOBIBSIC BECICI8E a) Bales t) feaales Proa a groop of 61 aatopsies. totensic aedlcal ezailnationa. Japan, Bales, man age 40.fi yr. peasles. aean a4« 37.4 yr. 191CE ELEMBIS; tOTOPStBS: JaPaB: UOBTII1B; 1BSEHIC: CaDBIQBi COSUTi ctDOHIOK; COPPBB: IEO»; BEBCIJBT; IICIDH; 1»aS!5IOB; BaSGiBSSB; ROBIDI3!l! tKIKOBT: SC4SDIOI": StlEBlni; TJTHIII01; Ta»DtOB; ZtBC; GC1I: 3BOHIBI: LIVEH; KIOBITS; CIBEBBTS: CZBBBEUOR: HElBlt BDSCLSS; eilCBBaS; SPIEB8; lUDlSS; JOBtl! R'TllS; C01E»B»TI»! E»»ld«TIOSS: SSI; fCBHSIC BEEICIBR 8EKBESCB _ Jenkins. B.B. 1979 «Sl-600/»-79-Oll9, 18» PP- Taka«a, fl. Soiuki-taaaaoto, H. Amanov K. Terai, B. 1980 Archives of Iniioni«ntal Health 35(1)i36-«a Takaiia, H. Sniakl-Iasumoto. n. Itano. K. Terai, B. 1940 archives of ?n>itonaental H«altn 35<1).-36-«a (BBXT PJGB) ------- Ittiiony 1MO-36-0 ------- IrtlaoiT •JMO-36-fl SI lt« 121.75. H 830 C. B? I63S C. »P 1 M 89 t 886 C. 10 •• Eg at 960 (CORIIttED) lissas 3562 Hn., 3563 Long 1 EIPOSOBE BOUTE 1 1 1 1 1 I 356 1 Riscle 4 1 f 1 1 1 \| t \| \| \| 1 1 1IUTTXC1L HETHOD U n •QMS. or cisis a) 3 M 2 a) 9 b) 13 c) 23 « M a) 5 b) I1IOE a) 0.22-0.52 ag/g («et •t) b) tot giT«n a) 0.011-S.067 iig/g b) 0.033-0.58 ag/g c) 0.023-2. « ag/g Vet t SIJI \| GEIIUL IBFOSRHIOl 1 1 1 a) 0.33 or - 0.17 \| I) Sales ng/g (et it) \| t) Paaalaa b) 0.28 or - O.ao \| >9/9 («t >t) j Proa a groip of 1 antepaiec. I foienatc aedlcal exialnatiooa, Japaa j tlm, aeaa aae 40.6 jr. Fcaalea, I lean aga 37. • 7r. 1 \| IF 1C! ElEHIItS: 1 CITOPS IBS; J1PK; I I10III8R: 1BSZIIC; CIDBIOR; CO Bill; \| CRBORIVK: COPPEE; I BOB; HEJCDBI: \| IIDItH; glGIISIII; R1IG1VE5E; \| BDBIOIIB; IIIIBOIT: SC1IDIOB; \| SILIIMS: TH1EIBB; T1R19IDR: IIITC: \| C3CIB; SBOalBZ; UTEB; KIOBEIS; \| CIBIBBOU; CZBEBEUIB: BI1BI; I1TSCLES; \| IHCBEISi SHEER: LUISS; 1OSII; \| BITHS; COUPMiTIT! EHIB1TICITS; SEI; \| PCBIISIC BIOICIRE 1 1 M 0.029 B9/J \| a) Controls b) 0. 27 ag/g \| b) Vorfcer qcoap I c) 0.32 ag/g 1 c) lorker qreip II fet vt I Medians \| Ecceaaed r«fiaerr and saelter \| vorkers, ages 55-76 jr, exposed to 1 >«aT Mtals 1-3 iecadas. Tiae 1 tctncn zetlreieat and Aeatli 0-1.5 fr I Centrals, ages 43-72 jt, »ao lived SO I ka froa t&e factory. Svedea. 1 \| SIEDEI; ClBl'ESS; KINETS: LITER: \| ICIGS; COBPaBaTirS ITllVAIIOIS: \| IICOSTSIll RIGIEBE; SEaSBBERERT \| ItTBODS; SITIKOJI; 1BSBBIC; CSDBItJB; I \| CISIDR; CEIOBIDR; COB1LT; COPPEE; \| \| 60IE; IBOI; UBTHlIiri; LIU; 1 \| B1BS1BESI: SnCOBT; BOLYSDEIOg; I \| EBOSPBOSBS: 8V9IDI«R: SC» IDIOT; I [ 2HEIX1M; SIITEl; TIB: TOBGSIEI; I \| HIC; SMITE R1ZMOS: HDOSTBIll 1 \| Enrrs; SBEITEBS; TiLinaitu r i 1 a) lot gir«n a) 0.01 or - 0.01 1 at Bales bj Rot glf«t tg/g (w«t vt) \| t) Faailas b) 0.02 + or - 0.02 I "3/9 Cet vt) 1 Ftoi a qrcuF of 61 aatopsiea. 1 fcienslc a«Ucal •zaainatiaiw. Japaa. I S«l«s, Man ag» «0. S rr. Tcaales, I aaaa aga 37.4 yr. I HtCE ELIRERIS; 10TOPSIBS; JIP1I; I itiBini; usEiic; cjsHioa: cosiiT; \| CEEC9II4; COPPBBJ 1801; HBtCOBI; 1 iinaa: aiGiisitjB; uicansE; 1 lOEltm; iiiiROH: scuDioa: I KlIBCTBi TIIHIDE; TUlDlna; IIVC; I CC1B; MOBIBE: ill ft; KIOIETS; \| CII!Bt"«.: CltEBEU-OH; BE11I; 809CIES: I tttctMS: SPtlBI; IOIGS; lOBTl; I RITUS; COIPUlTIf! ITILUITICHS; SIX; I fCICISIC RIIICIIE 1- BZFTBEVCE lakava, R. Sazafci-Tasvaoto, H. ftaano« K. Tcrai. 1. 1980 accaircf of EaTlronaeotal aealtk J5(1):36-« Braaeff D. lordberg, G. Matet, P.O. 1980 Science of tie Total EDTlronaent 16:13-35 Tnkava B. Sazaki-Iasaaoto, S. laaaOf K. Tecai, B. 1990 lrcfclr«s of ZBTlroiiB«Btal Baaltb 3 (1):3«-4« tsJ to (itrt tiGE) ------- HtO-36-0 itl 121.75, » (30 C. BP 1«3S C, TP 1 aa 89 at «8< C, 10 u Bg at 960 (COITIUBD) man 35« •aieteaa 3566 Spleea ZirOSVH BOOTB lUlITXCal BZTICD II 11 •man OF CUES a) C b) 3 aj 9 b) 3 sues a) lot give* b) lot given a) lot give* b) lot give* BE1I a) 0.01 * or - 0.02 ag/g (vet vt) b) 0.01 » or - 0.01 ag/g (vat vt) a) 0.03 » or - 0.08 ag/g (vet vt) b) 0.01 « or - 0.01 ag/g (vet vt) etltUL XBTOIB1TXOI a) lalaa t) reaalea ftoa a groan ol 61 aotopaiea. forensic nodical ezaainatioaa, Japan. Rales, aeaa aga ao.e jr. Taaalaa. aaaa age 37.1 vr. IBICI E1EBEB1S: aOTOPSISS; J1P1I; •maim: iBsiiic; CISBXVB; COBU.T; cBiosiua; COPIIB; 1101; BIBCDBI: 1ICCTI; BlGIESinB; BlieillSS: toEiDiia: iniBOR; SCIIDIOM; snmii; Tiiiiioi; wiiDioa: ziic; 601D: BBOBIBS: 1ITIB; KIDI1TS; CIBIBS55; CIBEBCUOB; B11B1; BOSO.BS; EIBC1I1S; SPlEllj LOBSS; ICBTi; BITltS; COBPUITITI ITlLVmOIS; SEX: FCBliSIC BlOICin a) Bales t) rcaalaa fcoa a group of (1 aatopaiea. focaasie aaalcal ezaaiaatioaa, Japan. Bales, eaa aga ao.6 re. Faaalea, acaa age 37. TE. 1B1CB ILBBIBU: 1CTOP3IES: J»1B: ItSIIVIl; IBSIIIC: ClDBtOI; COBUT; CIIOBIVR: CCEPE1; I BOB; SEBCUBT; XIDIOB; B16IZSXVB; B1I61IISE; BVBIDIIffl; 1BIIHOBT; SC1BDZOB; SILBII1!; TITIBIOI: TlUOIOBi IMC; eciB; iBOBXit; IITEB.- siniirs: ciinivi: CMDEILOB: IEIII; HBSCIBS; piicins; sttni; itiiesi IOBTI; •ITILS; COBMB1TIVE ETILOITIOIS ; SEX; ICIBISIC BZEICXBI BBIEtEICB Tnkava, I. Suaki-Yasuoto, R. laano. K. Terai. B. 1980 Irchivea of Environmental Health 35(1):3«-«a Takava, B. Suzaki-TasuBOto. B. aaaao, K. Terai, a. 1980 Irehivea of Enrlroaaental Health 35(1):3«-aa U) ------- ixeclor 1260 11096-82-5 IUCT rosaou OIKIOII OB aiDCTiiaxi» ussoe 3567 Blood. nbola 1 1 1 1 I ElfOSUBE MOT 1 t 1 1 1 1 immcii RBTBOD CC-EC 1 IOHBI8 OF C1SBS a) 36 bj « 1 1 1 1 SHOE a) lot applicable b) lot detected I IEII a) 8 ng/g D) lot detected GtllBlI. IirOSBmTIOl >1 1019 Ca»l residents, 1 positire sinple B) volunteers Bean of positive siiplss. Llnlt of •casareient, 4.4 «g/g Claselr latched, slnltaneous control tuples «er« not provided foe analysis along with those fros the 36 love Canal area residents saipled. licking leaaingfnl control ot literature data relative to tie significance of the lav residues faand la th« field saiples analyzed. BO definite conclusions can l« dravn fro* toe results reported. lesideits of lew rork. controls. eiploree* of the Enrironaantal Protection Igencr anS aiirersity ttidenta, north Carolina. Ill 10 K: IOITH CISCtlll! BLOOD; KaSntraZII BET BOOS; CUlOSItl OKUZC tcttatns; CHLOBOBiiziiiS; HflCnOICEEREir; POlICBLOBIHilED EICBHTIS; POPU11TIOJ EIPOSVII imsEicz Bristol, O.I. 1980 EM-MO/1 -90-036, »0 pp. Irsenic TMO-38-2 1C «tl 74.921«, » 817 c at 28 atn, BP «13 c (Biblines), TF 1 nn Eg at 380 c. 10 nn Bg at MO C N5 1 TISSUE 1 1 1 I j«e 1 tort* 1 1 1 f 1 1 Mood I EIPOSBBK BOOT 1 1 1 1 1 1 1 1 1 1 : i iinniciL 1 StTtm ri I I I I Coloriietrr I IOSBSS 1 Of USES I 1 1 2 1 1 B1BSI •oge detected \| 1 lot applicable (IBtl Bill \| Gllllal IIFOBBaTICI I \| •one detected \| Bales 1 I Tros a gro«p of tt autopsies. 1 forensic sedlcal exasinatioss, Japan. j Hales, sean age 40.6 yr. resales. f seas age 37.4 rr. 1 \| It ICt cllRIItS; IROFSRS; JIPII; I lIOBIfM; 1F5ZIZC; C1DJHTB; COBILT; 1 cnonra; COPPEP; 1101; BEBCOST; 1 I IBIS!; giciisna: KaieuzsE: 1 loeiBra; union; scinioi; f SE1EIIVB: TIIUIOB; nUDIBB; Zinc: I SCID; Bionit; LITEB; EIDIEIS; \| CIIEBB91: CIHBEIUB; BEIBT; SDSCIES; \| tllCIEaS; SF1EEI; L»CS; 1C«TI; I amis; CO»FIHTITE ETiioitieis: SEX; I ICHIStC IttlCIlE 1 1.3 ag/g ( Ceath liTolvisg as. Tiss« speclseos 1 lilt ted 10 SCH casat by prior 1 astoeties. I 1 ICITB cuotiii: IHTOKI-S: ctBujts: I errii FOISOIIIG; BLOOD; BOIESJ BBIII; 1 Bill; UTtt; msctBSt sni; »aILS; I BtimSSltt lETBOSS; BR1LS; TOlEtSlC \ ciitcm 1 BETEBEBCE Tekana. B. Saz«kl-Tass,soto, B. Isaio, It. Terai, s. 1980 Ircnires of Enixonsental Bealth 35\|1):)6-4 BcBay, l.J. Bldsoi, B.P. BolitKj, V.S. 1979 Jonrittl oC Inalrtlcal Toxicology 3:222-223 ------- •rseilc 7MO-3I-2 If lt» 74.9216, Bt 817 C «t 28 ats. H- 613 C (sebUMs). TP 1 aa B« at 380 C, 10 is 89 »t ««0 C (COR»HED) «SSOI 3570 BOM 3S71 Brala 3ST2 trail 3573 ••it meson Mtni iiunxcai BIT 10t Color! aetry I* Coloriaetry •mm or cms 5 2 BUGS 0.1-2.0 ug/g a) lone detected b) so»e detected c) BOM detected d) < or - 1.3 119/9 (net «t) 1.0-2.0 ag/g mi 1.3 ag/g a) lone detected b) lace detected c) Rone detected 4) 0.31 » or - 0.5» «g/« t««t »t) 1.S ag/g GEIIUt IIFOBIaTXOI teatks iavoliing as. lorsals. 0.1 tad 0.2* toy? (secondary raferaace) . Tii»< specinns Halted in soie cam by prior autopsies. 11 eikvaed tcdlea baried 2 «k-91 jr. ICITB cHoiin; tno?siss: CIDITEIS; eiTlt NISOIIRG; BLOOD; BOISS; EE1I»; mi; Litrn; TOSCLE3; »ILS: SKU: iiisvinni BIT BODS: IRILS; FOBEISIC (IBKIII a) Hales* cerebral* 13 subjects k) Vesales, cerebrva, 5 sabjects c> Rales, cerebellne. 11 aabjects d) feiales. cerebell.ua. T labjects fcoa a vcoap of 61 autopsies. forensic aedical ezaaiBatioas, Japan. Hales, aeaa aae 40.6 yr. resales. M«B aqe 37.* yr. tBICt ILBHtlTS; 1BTOP3IIS; J»P11; lIOHIin; 1BSEIIC; C1DBIOB; COB1LT: CBlCHIOl: COPPBE; IBOl; BESCOBT; IBCIDB: aiGiisiua: IMGHISE: tiEiDioK: iniROBi: SCMDXDH: SUKim: TITUIDR; 7HIDIOB; ZIHC; GCID; BBOBIII; 1ITE1; KIDIETS; CIBBBBOl; CEBEBEtlOB; BUST; HO SCI. IS: E1ICRE1S; SntXt; IDIOS; ICBTl; BITIIS; CO'PIBiTITZ ETlLDiTIOIS; SEX; KlflSIC BEDICXBE faaths larolvinq Is. Tissue iieelsens llaited Is aoae cases by prior aatopsies. 11 eihased bodies bocied 2 ttk-97 TC. BCPTI citoiiBi: imopsus: CIDMEBS; DITIL POISOIIISi BLCOD; BOIES; EB1II; BUB: llfEB; HOSCIES; SKI I; MIIS; BB1SOBS1SI1 BETBODS; 1ET11S; FOBSISIC BtCICII! ftviev. 2» repreoeitatiTC Fce-asalTsis treataeats ace tabelatel. Ihe feasibilitf of a kclistlc, no-«asli policy for hale analysis Is eatlised and supported. BEVIE; TBtCE I1IIERS; Bill; IBSTSUII; BElSHBElin SETBODS; tfllLS; PBOTIIMS; COSPiBlTITI itiinTiois; iineiioB: HTXHOII: 1ISEBXC; BUIDB; BSOSIBE; C1DBIIB: cucioii: CBICBXIE; CBROHXOH: COEILI; CCPPIB; 61ILIOB; GEBBinOHs GOLD; ICDI1E; IBOl; LlaTBllVB: IE1D; iieiEsiOR; iiieiiESE; sracnsT; CCmDEIOH; HCKEL; IBOSPBOBDS; toiissius; BOBiaiati; SELEIXIH; SIHCOI: SII1EB; SODXOB; STBCITIDB; SOLPOB: Til; TXltlXDtl; TOI6S1EI; IIIC: TIBCOIIOB BIfllEICE HcBay, I.J. Badsoo. S.P. Baling, T.8. 1979 Jaarnel of analytical Toxicology 3:222-223 Tukava. fi. suznki-Tasaaoto. a. &aano. K. Terai. H. 1990 IrchiTes of EnTiconsental Bealth 35(1): 36-4 IcBay, l.J. Radso. H.P. Boliag, T.B. 1979 Journal of Analytical Toxicology 3:222-223 Cbittlebocosgh. G. 1980 Science of the Total Eniiroasent U: 53-75 (HIT PtSZ) ------- IM0-38-2 if lt» 7.921C. IT 817 c at 28 atm, BP 13 C (aabllaea). « 1 » Ig «t 380 C. 10 aa Si t («0 c HSSBI 3S7» «»ir 3575 I«lc ixposms wot laatttiox laaalatioa 1 1 3:16 Stir amnmi 1ZTBOD ColoriMtrr u r •VMB> or cisas 3 * 1 1 Mies a) lot applicable 1) tot applicable e) lot applicable A) lot applicable •) lot applicable a) 10.8-76.1 ppa b) 8,26-11.7 pp> c) 3.33-K.O J>P« t) 8.6-63.1 ppa •) 4.22-12.7 ppa f) 5.61-38.5 ppa mi i sunn itrciBitioi i BsreiCTCj 1 1 1 1 1 1 a) C.O 119/4 1 •> <• •• ««tr 1 BcSay. l.J. b) 9.0 «j/« 1 M «•» 2' »e«lp aalr 1 Hodaon, 8.F. c) 2T «g/g I c> Caw t, »calp aalr - proilaal I soling. T.S. tj 10 «j/j I J) CIM 3, acalp balr - U«tal \| 197 «\| IS «j/7 I «) Can 3, >aal« 1 Jaanal ot analrtleal \| tmtas livalTtnq >«, T!MM t Taxlcologi 3:222-223 1 ;«eiMm liilt«4 la IOM caaa* bi 1 1 prior aitocila. » 1 11 «a«ad tedl«« 6«ri«d 2 «k-»7 re. 1 i tens citoim; tnorsitss cunmss i I ittu raisoine; HOOD: BOIISJ BSU»: i 1 Bill: lilts; susciIS; sell: mis; 1 I iiastniHSit iRioas; BETU.S: roiasic i i ncicni i i t 1 1 a) lot siren I a) rtoa acaa, steel bconz« >crk«n I claf. J.S. b) lot gi»«a j tl fcei lead, otMr norkcrs it I sale, I. cl lot glTea \| factory 1 cross, J. p. dj (at girea 1 c\| rrm a«ad, «te»l tcoaie rcrlters at I 1977 e) Hot flT«a 1 ctfcct factories I Journal of tbe SocietT f) Rot oiren \| if mm patlc area, steal broaia 1 of Occupational I >ctkr> I MdlclB 27:102-104 1 <) tmm pabic am. otaar «orkets at I I tactoiT \| 1 f) froa pabic acea, steal brcne 1 I wcikeri at other factories f 1 I 1 letters ID factory ihere arilae 1 f faetorlea, U.K. I I iiiizd meaci: umrs; MTI i r ICIJOiriS; BllB; »I13; CORM9IHTE I I IH1B1TI01S; IimiSTim HTClni; I 1 iisnic: cisi; HULTB nziBDs: i \| IHIDSItlH IIROSPEEIBS \| i r t 1 I t r«»iei of «orld literatare ot tie I Jenkitt, D. ». 1 accanlatloa an blooonceatratiaji of I 1979 I selected toclc tcacw » ------- Iticiie 1MO-38-2 II Itl 7«.921C. HP 817 c at 28 »t», BP 613 C (sabliaes). TP 1 •• Eg at 380 C. 10 •• Rg at MO c (COItliaSD) 1ISSBI JS77 Mart 3578 Md»«T 3579 Iido«T iipososs BOUTS aEURICal HIT BOB 11 11 11 itmen or casss a) 10 b) S a\| 23 b\| 3 at 8 b> 9 cl 9 UBSS a) < Or • 1.* «g/g (««t •) b) BOM detected a) < or - 1.7 eg/g (Mt t) b) < or « 1.« ag/g (»et rt) a) 0.0030-0.01* ag/g b) 0.0020-0.016 ig/g c) 0.0020-0.052 ag/g I«t vt mil a) 0.1* * or - 0.«» »g/g (««t rt\| b) Bone detected a) 0.1* * or - 0.43 ag/g («et »t) b) 0.»7 t or - 0.81 ag/» <»et »t) a) 0.000 ag/g b) 0.0095 ag/g e) 0.0038 ag/g let «t leiiaas esisui IIPOBIMIOI a) lales t) Faialvi ttoa a groap of Cl aatopziaa. Coranatc aedlcal exaaiaatioast Japa. I<1<«, aetn ag« 0.< IT. F«ul«s. •cai aga 37. jc. nici miens: aoropsiss; JIPII: itmiioR: iissiic; ciosioa; COBU.T; ceioiim: CCPPSBI 1101 : RSICOIT; iirxvi: 816IISIOR: BUGIIISI: SD3IBIUJ; llHBOiT; SCllDlnB; snsiiiH; UTiMioB; vinoioR: me: GC1D; BBOBIII: UTEB; SIDIZIS; CIBIBinS; ClBEBSUORi HS1BI; HUSCLSS; limns: sptEE«: miss; IOBTI: IIT1LS; COSJ1BHITE ETIIDITIOIS; SEX; fCSHSIC BIOICIHS •) Ralas t) T«l«l«s Troa a group of Cl aatopsies. fcrnalc medical •xaainatioos, Japan. Balas, a«aa ag« »0. 6 yr. ?aaal«s. iaaa age 37. jt. met nsBsns: aotopsisss JIPII; iiinin: USCTICJ CIDHIDB; coaiu; ctBOBim: coppiB: xioi; Hiicnsi: IB tins j siciisiUB; nieiisss: BdsiDiiia: iBiiROii: sciiDins: SItSBI0H; TIIMTOB; T1MDXDR: IIIC; 6010; B10HIII; LITBB; HOISTS; CIBtBBOI: CIBEBBUaH; HS1BT; IVSdBS: fltCBElS: SPISII; IDBSS: 1CBT1: IITILS; COBP1B1T1TI ETltOltlCIS; SIX; ICIIBSIC iinciii i) Costrolt k) war liar qroap I c) lortar gteap II Caceaaei cafinery aad saelter vcckars* ag«> 55—76 jcf expoaed to taaTf aatala 1-3 decaaes. Tiae betMea retiieaent anl death 0-1. S yr ia graap I an! 2-19 It, qioaf II. ceatrols, ages 3-72 yr, iko llni SO ka froa tb« factory. Sweden. SBCCIB; CIOITSBS; KIDBETS; IITSB: UlSSi CORPliHItl 1T1101TIOBS: IIDCSTH11 II6ISIS; RSISOSERIBT SIIBODS: 1BTIBOII; IBSEBIC; C1DBIOB; ClStdl: CBBCHIOR: COEltT; COPPBB: COLD: IBOB; X1I1R1IOB: IBID; B1B61BUI: SIBCUBT: HOITBDZBOB; iiospioivs: BOBiDiua; SCIIDIOS: EILZBIDB; SXIYiBi TIBj laBGSTSI; tnc; HSttTl UZ1BDS; IIBBSTBIll EIIITS; SREIIEBS: TStmiOl ESnUBCS lakava. H. Saiaki-Tacaeoto, R. taano, K. Teral. R. 180 Irehives of EBTlrooaentsl Health 35(1):36-«» Yakava. H- Soiakl-Iasaaoto. R. laano. E. Terai, B. 180 arcaivea of BDTiroiaectal Healtk 35(1\|:3<-« Brana, D. Vordberg* 6. Mater, P.O. mo Science of the Total CnTlronaaat 16:13-35 ------- manic 740-18-2 a att T.921C. «P 8IT C at 28 ata, » 613 C (artliaex) . TP 1 aa If t 380 c, 10 » B« «t *« C (CORIIITED) IISSffB 3560 LlMr 3!»f Ilmt BZF031BI SOWS 1 immClL IRBOD (1 11 ( 1 1 3S82 f Colorlaetrr 1 U»er 1 ( I i r 101 em or ctse «> IS b\| 8 t\| 8 b) 9 c) 10 8 t 1 BMOE U1I 1 EIKU1 IirtJtBlTIOB I SttttXICt 1 1 a> < or - 3.3 ag/g (mt al «. » + or - 0.»S I •) Bal« I Takava, 8. rt) aa/» (vet «t\| 1 It ?«••!•» t S»«W.-raanaota, 9. ») COM tetceted b) ROM etect«d I 1 nao. !. 1 rcoi i Troap at SI Mtapai, I T«r»i, 1. 1 fomdc Mileal «xln«tioBs> Japan. I HBO 1 Bil«i, •••• aq« «0.6 rr. r«al», 1 irchires of 1 nu v> 3^'* rr- 1 ZDTlcg»eBtal Jtalth 1 ( 35<1)i3«-«» I «ICE taettrs; tmotsitst jwti; i J liealOTI; IISHIC; CIDnVI; COSU.T: 1 i cnonoi: oo>m: IBO»S BSKOEI: i I i»iva; sioMsitja; BUGIIBSI; i i tviigiim: I«TUO»T; sctmim; i I sniim: Timrtw; nuozvi; z»c: i I sen; Btoaiii; IITEB; KIOIETS; i i ciiuan: cnnriLOB; IBUT: SOSO.BS: ( 1 Micsus! SPIHI; IDKJS: tont: I I srms: coapiiinn iruomoTS; six: i \| KinSIC VEDICtK 1 > i > 0.0019-0.013 •«/« fe\| t.0030-C.(»J >g/4 C) 0.0020-0.0050 04/9 let lit 2-SS ig/a 1 1 a) 0.0030 09/9 1 «l co.troJs r Sraa. 0. b) 0.0085 ay/g r t) larkec fccan I 1 tortbarg, 6. c) 0.0*0 «j/g \| c) forkar grcop II 1 lestM, S.O. rat «t I 1 W80 Hediaiu f X«c«as«d r«£inry and a«lt«c I Science of tfce fotal \| «ort«n, a«« 55-76 fr, aipoced to 1 tn¥lcoo«ent 16:13-35 I «g«x 1J-7J TC, iia llnd SO ( I ti fcea tie laetarr. Svaaen. 1 1 1 1 5«lt!«; cm»E8S; KioiRSi lirfs: I 1 tnes: COBPISKITI miuiiois; i \| IJMSTBIU BIGIHB; B!lSti!Bt»T I f HttOOS; IRUOir; USZVIC; ODHBB; I cisiai: cBBoeidd; COULT: COPPH.- I coit; iso«: unBHns: uio: i FJIGIIISB: mean; BotiBDUm: i taaspvnvs; BOSIDWB: sciinra; i smiiaii; sitfre: TI»: Ttrissrjs; I ZIIC; g»HB BaZIEOS; IHDttStEIll \| TllltS; SRItTEBS; 1XUQHV8 1 1 13.6 09/9 tcath* i»»ol»ioq it. taimtlt, 0. OS 1 BcBay, l.o. aid 0.2* 04/4 (aecoataiT referance). I Badaoa, P.P. Ilane speclaeaa Uaitel la soie 1 Bolinq, r.B. c»e* br prlcr aatoasiea. 1 1979 1 Joicnal of mlrttcil It eskaaad bcdiea bortel 2 rt-7 rt. 1 Toxlcoloar 3:222-223 t ICBia CIIOITU; 10TOPSIIS; C101TKS; I sun POISOIIK3: aiooi; BO»S; miij i Bill: UTtE; BUSC1ES; »»HS; sri>; 1 •tisninn IRBOKS: SHTI.S: rosusrc i ttnatt i i (KIT PIGI) os ------- linilc 7MO-38-2 II »t» 7I.921C. BP 817 C at 28 ata. tt 613 c (snMiMS). TP 1 •• 84 at 380 C, 10 a* Hg at atg c (COITHDBD) 1ISSTJE 3583 lung 358* Ing 3585 Raacle EIPOSOBB S001I luinictt BXTBOD It Ik U IHBESS OF CASES a) 5 b) » a) 9 b) 13 0 22 a) 5 b) 10 URGE a) < or • 5.3 99/9 (wet t) b) < or » 0.5 ag/g (wet •t) a) 0.0010-0.018 ag/g b) 0.023-0.013 ng/g c) 0.01»-0.21 ag/g let "t a) < or » 0.50 ag/g (wet "t) b) < or * 0.85 ag/g (net Wt) Bill a) 1.3 * or - 2.3 ug/g (wet wt) b) 0. 1« » or - 0.27 ug/g (vet lit) a) 0.0080 ag/g b) 0,013 ag/g c) 0.08 ag/g Set t Bella as a) 0.10 « or - 0.22 ag/g (wet wt) b) 0.09 « or - 0.27 vg/g (vet vt) etIZBlI. IIFOXB1TIC1 a) Rales I) Feaales It am a groap of 61 aatapsles. forensic nedieal examinations. Japan. Bales, aean age «0.6 yr. Feaales, aean age 37. a yr. IB1CZ ZIZBI1TS: HJTOPSIBS; J1P1I; noiiim: iBszvic: ctsaioa; COBH.T: CHORUM; COfPSB.: IBO«; BEBCOBT; IICIUB; BlGHlSIHB; RafGkBlSE; IIIIIXDR; JITIBOIT; SCSIDIOB; GCIO: BKORIIZ: IITZ8: KlfilZtS; CIBZEKD!!; ClfEBZUOB: HE1BI; RDSCLBS: fllCBZAS; SPlEZ-Ij 1QBGS; AGBTk; BIT11S; COBP»B>TITS ZTUD1TIOI5; SBX; ICBIISIC R1CICIIZ «) Controls t) Vorker gccqp I c) Vorker grcnp IX leceasai refinery and snelter •crkers, ages 55-76 yr, exposes to teavy aetals 1-3 decades. Tine tctmea retireaent and death 0-1.5 yr It group I and 2-19 yr, group II. Ccntrols, ages 13-72 yr. vho lited 50 ka froa the factory. Sweden. StZDZl; C1E1TZBS; KXDIZTS; 1ITEB; imest coapiBiTiT! zTiigiiiois; XlCISnill. BTGIEIE: BE1SDB1BUT iHHons; imsovi; iismc: cmaioi; cisnm; c HBO sio a ; CCBIIT; COPPII; COII; IROI; HHIBIIOB; LEU; E1161KS1: BtECOBY; B01TBDIIOB; tlOSPBOBdSi BOBIBinB; SCUDIOT: SKZIIM: SIITIP. ; ?II; TBiGSltM; IHC: BZtlTB B1Z1SBS: IHIOSTBIil PltHTS; SBZITEBS; TILLnBlOR » Bales t) resales Iroa a groap of 61 autopsies. forensic nedical exaalnations, Japan. Bales, nean age «0.6 yr. Fcaales, aean age 37. (1 yr. isict SLHiiiS; inTO?sizs: JIPSI; iicBi»oa: iKszmc; UDBIDB: COBU.T: CBIOBiail; CCPPXB; IBOI; RZBCtBT; IICIOR: »«isx0fl: BIIGIBZSZ: BDBIBMl; 1IIIBOK; SCiUBIDB; sttzixtii; TIUIIDR: TiiiDioa: znc; GCID; B30BIII; IITIB; KIDSSTS; CIBEBR31; C1EEBEXLOB; BJiBI; BOSC1BS; PlICKIS; SPIZZI; LDBGS; 10B11; BIT«LS: C09P1MTITZ BTlLDtllCBS: SEX; fCIZISIC BECICI"! BZFEBEBC5 Takava. H. Saznki-Iasaioto, a. leano* K. Terai. 9. 180 archives of iBTiconnental Bealth ( ): »« Brane, D. •ordberg. G. •ester, P.O. 1980 Science of the Total Environaeat 16:13-35 Yakava, n. SvznU-Tasaaoto, a. laano, 1C. Terai, S. 1930 irchires of XnTlronnental Health 35(1):36-«» (KIT PIG!) IS3 VD ------- Itsenic m0-38-2 Ai Its 71.9216. IP BIT C at 28 at.. BP 613 C (sublines). TP 1 an Bg at 380 c, 10 •• 89 at 440 C (C01TIIDBD) TISSUE 3586 Bnscle 3587 Hall 3588 Bail BXPO30BE BO01B Ingestlon Inhalation ABA1TTXCAL 8ETBOD Colociaetry u BUBBBB OF CASES 5 9 BAHGE 0.8-5-0 ug/g a) 15.0-188.0 ppi b) 0.97-6.00 ppn c) 6.45-53.3 ppn d) 10.8-60.9 ppn e) 2.98-4.81 ppa f) 1.06-5.79 ppn (BEIT BBaB 3. a ng/g a) Bat given b) Bat given c) Hot given d) Bot given e) Bot given fl Bot given • PASE) GEBIBAl IHFOBBATIOB Eeaths Involving Is. Bornal, 0.43 ug/g (secondary xefeieDce) . tissue steclseas United in sone eases by prior aotopsles. 11 eihued bodies burled 2 «k-»7 vr. Case adnitted to eaergency roon «itb gastritis died 1 day later after x«eoning cyatotic and Incoherent. ICBTR C1BOUBA; IIROPSIBS; C1D»¥EBS; BITU POISOIIB6; B100D; BOBBS; EE»IB; BIIB; iiTEB; aoscus; SRTB; i»ns; mSOBESBST BBTHOOS; RBTA1S; T01EBSIC BIDICH? _ a) Fron linq«rs, steel bronze workers fc) Icon fingers otber workers at factory c) Fron lingers, steel bronse norkers at other factories 1) Fron toes, steel bronze workers e) fron toes, other workers at factory f) Fron toes, steel bronze vcrkers at ether factories Icrkers in factory where arslne poisoning occurred and in other area factories, O.K. OBI1ED KIHGOCB; ADULTS; BBI1I fOlSOBIBC; BUB; B1I1S; COBPtBlTIVE IltltUTIOBS; IHDOSTBU1 HIGIIBB; IBSZHIC; COST; BUITR B1ZABDS; IIDOSTBIil limSPRBBES . 1 review of world literature on the accnnolation and bioconcentcatian of selected toxic trace netals in ho wan hair and nails and other nannalian hair, far, nails, claws and hoofs. latnlated ty geographic area. subjects, sei. age, exposure gradient, analyses in ppn. and authority frcn over 100 references. JFSICM IOSTBU.I1: ClBADl; CEHTI1L IB1BICS; IOBOP8; KIDDIE EAST; BBS 1I1IABD; SOOTH ABEBICA; 500TBEAST 1SIA; OHJTED ICIHBDOB; OH IT ED ST1TSS; BIIB: BAILS; BETIEW; ABTIBOBy; IFSEBIC; EOBCB; CADIIDfl; CBBCBIOB; CCBALT: COPPIB: IEAD; BSBCOBI; BICKEl; SELIBIOH; TIB; TABAOIOI); AIB ECIIOTIOB; ABIIAl POFOLATIOBS; EICACCnaDIATIOB; BIOISDICITOBS; LAHD ECIIOTIOB; POPDLATIOH EIPOSOEE; B4TBP ICIIDTIOB; TBACV 31EHEBTS; BETAIS BEFEBEBCE IcBay, A.J. Badson. B.P. Doling, V.B. 1»79 Journal of Analytical Tozicology 3:222-223 clay. J.E. Dale, I. Cross. J. D. 1977 Journal of the Society of Occupational Redlclne 27:102-104 Jenkins. D.W. 1979 EP1-600/H-79-049, 18« PP- LO o ------- 7MO-J8-2 It Itl 74.9214. IP 817 C at 28 ata. >? 613 C (sablises) , TP 1 »• tg at 380 c. 10 •• Bg at MO C (COBTI1DED) TISSUE 3589 tancreas 3590 Skia 3591 Spleea EIPOSUBS SOOTE lllLTIICll UTBOD n Coloriaetry 11 IflaBES or cisss a) 8 b) * 4 a) 10 b) 6 SIR6B a) < or - 1.3 ag/g (mt b) loae detected 0.4-1.0 ag/g a) < or - 0.5S ag/g (vet b) lane detected BE1I a) 0.28 * or - 0.48 ag/g (et t) b) lose detected 0.66 og/g a) 0.07 + or - 0.18 b) loae detected Gtlliai IIFOiaiTIOl a) Bales t) resales Icoa a groap of 61 autopsies. forensic sedical exaaiaations. Japan. Hales* seaa age 40.6 yr. resales. aeaa age 37.4 yr. TBICE ZLBBEHS; aUTOPSIZS; JftPIV; IIOBIIUB; IBSEIIC: CiDBIOB; COB1LT; CflOBIUB: COPFBB; IBOI; HEBCOBT; litiuB: aaeiEsiai; aiieiisss; IltlDIVH: alTIROR: SCIIDIOB; s ii nua; TiHiioa: Taiaoiui; zitc; ecu; BBOBIIB; LITIB: KIDIBTS; C1IEBBHB; CIIEBI1LOB; IUBT; BUSCLIS; titcftEiS; SMi«»: lines; ICBTI: IRUS; COBCUHITE ETILUHOCS; SSI; fCIEISIC IICICIIE Ciaths iavoltiag as. lorsal 0.59 «g/g (secondary reference) . Tissae speciaeas liaited in sone cases by flior antotsies. 11 exhaled bodies boded 2 «k-97 yr. ICIta C1B01II1; 1UTOPSIES: CIDtfESS; BlTll POISOII1G; B1000; BOIES; BB»IW; C1IS; lira; BOSC1ES; SKIB; I1IIS; aiisnBtim HZTIODS: anaLS; FOBEISIC itDicias a) Rales t) Feaales Iroi a qcOBf of 61 autopsies. forensic aedical eiaaiiatieu. Japan. Bales, nean age 40.6 yr. resales. scan age 37.4 yr. Tiaci niazixs; mofsns: JJPAS; iimnna: USEIIC; cinaiaa: cosui; CIICRIOR: CCEPEB; IB01; REBCISI; liriOH; RIGIESIVB; ItlSaiESE; iiBiomi: niiRoiy; scaroioB; SZIEIID9; TIiatlOR; flUDIOB: ZIIC; eett; Bsoaiii: IIVEB; KIBBZTS; cisiBtan; CZIEBSUOR; IE1IT; ansciES; EllCSttS; SflEEl: LDieS; 10BU; BIT IIS; COBPaBlTITE IT»10«IOIS; SZI; ZCBZSSIC BZtlCIIX BZRBEICI Takava, B. sazaki-Tasaaoto. a. inaao. S. Terai. B. 1980 archives of Eavironaeatal Health 3S(1):3«-4* RcBay. a.J. Hudson, I.;. Boliag, T.E. 1979 Joaraal of analytical Toxicology 3:222-223 T«ka«a. R. Sazaki-Tasasoto, Hi asaao. K. Terai, a. 1980 archives of ZiTironsental Bealth 35(1):3«-aa IIEIT ------- Irscnie 7M9-38-2 la lt» 74.9216, HP 817 C at 28 at., BP 613 C (subliaes), TP 1 >• Bg at 380 C, 10 mm Bg at MO C (COITIIOZ9) IISSOI 3592 Brine EIPOSOB! BOOH 1 minion OTBCD j IOHBZH OF C1SSS 1 tuet reii etizsiL IIFOIBITIOI a) lot glttm a) 0.8 ag/g •) 9 ratal etildne, inarganic 19 b) lot givca ereatlaina t> 1* cklldm ILiiiq < 1 ka froa c) lot 9iT«« b) 2.2 ag/g . 2.5 ka froa aaalter. f) 5 ag/g creatinina tetal Is I q) 7 ag/g creatinine f) 21 riral bora, total Is 1 Mdlans 9) 22 riral girls, total Is c)-g) estiiatatf froa graph Seaool-aga enlldran living naar Pb sialtar in Ealgiaa. Controls fron IlieilftSl; C.DBI08; USIIIC; 1SSZIIC CBS1IIC COiPCOIDS; CBI1DBBI; iiDosmn. iisosrszsts: SRZUZBS; tlTUS; BIOOC; ni»; B1LGIOH; fcpuiiTio iiPosnBi: iniu isiis; \| UIE1B 1RZ1S 1 1 3593 US 1 30 a) 7«-93» ng/1 a) 3«7. 0 ag/1 I a) Iiposad icrkers, 1G-11S technique 1 Urine I 1 bj 91-9S3 og/1 b) 368.8 ug/1 t) Biposad wcrkers, ET-115 technique \| lie) «.»-23. 9 ng/1 e) U.5 09/1 e) Controls, 1G-11S technique \| \| d) 6.5-42.5 ng/1 d) 18.66 ag/1 «) Controls. ET-llS technique III e) 6.9-25.6 «g/l e) 14.73 ug/1 «) Baaitarrnnean sorters, 1G-11S \| \| \| f) 36-1180 og/1 f) 382.6 09/1 t€Ckniq«« I I g) 15.5-113.1 ug/1 arkars excoscd ta Is203 and S centrols. 10 Hedit«rra»aans, 10 Klglaa, totb possiblr •zposed to inorganic Is bat diffarant lisk ccnsasption. Data arailabla for velsntaars and attasptad saicidas. EHSlm; HE HE; COSP1HTIYI iTiiDiTiois; nismmi HEIBOOS; IBSnlC; IBSIIIC OI61IIC COaPOOIDS; tuts; iiDosttlu puras: IIRBU (IT1BC1ISB SEfEBEHCE Backet, j.p. Foals, B. laawarra, B. Braaax, P. Claars-Tkoraaa, !. lafontaina, 1. Verdarn, G. 1980 Invironseatal xasaareb 22:95-108 ncket, J.P. laanarrs, B. eels, B. 980 ateraational Irckivas f Occupational and nvironsantal Haalth 6:11-29 ------- U»lM 778»-»2-1 II-B3 Bl 77.93. » -117 C, B* -«2.S C TISSUE 359* Mir BIPOSOBZ BOVTZ InhllltiOn iiiLrricii RETROD IORBZB or CISBS « 11KI •) 39-216 ppa b) 22-107 Hi HZ1R a) 107.3 ppa b) 18.3 ppl GEBisiL iirosBancR •) Iftar 9 flays, loot sagiant b\| >it«r 19 days. 0-1 cm Ito» root 50-51 yc old sailor. »«»«r, Matacsa, naasaa, toiitinq. diarrhaa, abdoainal pain. BfBoqlobinaria, iatravascular haiolysls. aarroa leprcssien. ttioibocTterania. reaal failure. ptiipliaral utoropatky- ustmc; BUI; occnpi-ioiii HIUBDS SEiEincz slUlnson. s.P. RcHnih, P. Borsloy, S. Tobba. R. le»ls, 8. Thooli. 1. Mnterton. H. Parsons, V. Vllllaas. B. 1975 British Radical Journal 3(S983):559-5«3 Irsifta oiide, Irslalc acid. C2-B7-1S-O2 Bl 137.99. RI 200 C - (9 CI) (8 CI) 1ISSU! 3595 aria BltOSOBS BOOT I aiumcii BFTBCD IOHBZS or cisss a) 9 b) 1» tlBSt a) lot gi»«n b) lot gi»en SE»« a) 9.2 ag/g croatinine b) 11.2 09/9 cr«atlniae S1I!B»L mOBHlTICI a) Bncal ehlUrea b) chiHren near sa«lter Sekool-aije ehildraa liTinq »«ar tts ciclter in Belqiua. Control* froa meal aad arban araas. R1I6IKSZ; CIE8I05; »SmC; 1RSEHIC GfSirtC COITCTODS: CHI19RII; IBDDSTBItl IHOSPBSS1S; SBI1TZBS; BITtIS: BtOOC; UBIIS; BILGIBB; ICIOL1TIOB IITOSORB; »DS»1 1BZ1S; DIEII 1BI1S BirZISBCI Bucket, J.P. Eoels, B. Laanrys, B. Brnaax. t. ciMTs-Thoraaa , r. lafontaina, a. Terdnrn, 6. 1980 ZnTironaeatal Research 22:95-108 UJ u> 1tbastos 1332-21-t IIICT coiposinoi amoB OB OBIZTZBRMZD nssm 3596 Gastric liqola BIPOSOB! BOITE HI1LTTICH BITBOD Bicroscopy BVBBSB or cisss 13 S1BGI 0-2500 ferraqluoas todies/20 il (BEXT BE1B Hot 9iTen ?1SE) GZIIBtl IBrOBBlTIOB 33-72 rr olds nit! 1-50 yr occapatianal axposora ISBISTOS; OCCUPlTIOItL H.Z1FDS; IUBSS; ISDOS1BHI 1TSOSPBZBIS; DOST; II>BCB lErZBEECI Biqnon, J. Sebasties, ?. Bonchaoz, G. Boanaad, G. 197 IBSZBR 29:205-218 ------- ItbeStOS 1332-21-* IUCT coBfosmoB nno» 01 (COBfttDZD) IISSOB 3S97 Gastric llqaid 3598 Intestlae EXfOS«n BOOM lagestlos 1IUYIIC1L BETBCD Biereseopv IB I0BBEB I1ICI Bill \| CHIllt IirOlBllICl or CISBS i i a) 0-158/20 nl a) lot given I a) lorkers hiadllaq raw asbestos b) 0-»/20 al b) lot given I t) lorkers aaat factoring aabestos c) 0-3/20 si c) lot given j [rodacts I e) lorkers exposed to sized 1 iadostrial dgsts 1 1 33-M vr olds, »ith varinos disease \| occapatioaally exposed to asbestos. 1 \| JStlSTOS; OCCOP1TI011L B1Z1BOS; 1 iciss: occnpiTiont oisusis: I 1CTOPSKS; IIDOStlllL 1TBOSFITEIIS: 1 IQSI; nilCf 1 a) 21 a) not gives a) 150.0110 (!-5) I a) Controls b) 32 bl lot given fibers/a I b) lesidents wlta long tern, bigb b) 1«.3i10 ------- libestos 1332-21-* IHCT coBposmoi omoiM ct OIDITHHIKD txssoi 3600 larynx 3601 liver 3602 mag 3«03 HBO nOS01J BOOT! Inhalation Ingestion iiunicai BETBC8 n licroscepy n HI Bicroscopy BDBBEB or cists 2 a) 20 b) 32 1 13 fllGI a) lot applicable b) lot applicable a) let gives b) lot given a) 1.4x10(17} -3.3x10 (E»71 fibera/g b) 2. 7x10 (E+7) -6.5x10 (E+7) fibers/g Dry »t lot deternined-200,000 ferruginous bodies/en cs Hal a) 590 fibers/eg b) 3600 fibers/ig Dry vt a) 153. 5110 (!-5) fibers/g b) 32. «1 10 (1-5) fibers/9 Ish »t a) 2.1x10(17) fibers/9 b) 3.9x10(17) fibers/g 3FT Vt Hot given 6HI11L IIPOS81TIOI a) Patieat 1. Fiber eea> length 2.» a, Man Planter 0.08 a. Bate ctiT'Otile thu aiphlbole fibers, lo femgieaoc todies l» Patiemt 2. Fiber Bean length 3. « i. Bean lianeter 0.1* n. Bore aapiiaole tkan chrysotile fibers lorsal tissue. fatleat 1. age SI yr. Exposure tetceen aqes 13-15 Tr in welding factory and tetveen ages 20-10 Tr as electric arc Holder. Patient 2, EBoker, aqe 51 yr. HeaTy exposure in asbestos ceaeat plaetv pre-Vorld Var 2. EneBsoeoBiosis. bronchitis. Benign polyp on vocal cord (Patient 1) , sqoasoes cell caiciaoaa of larynx llatieet 2) . long opacities, costopkrenic angle obliteration, plevral »all thickened. FIHCt; ItDITS; CIS! HISTOBI1S; IIDOSTIIll DISBISIS; M10PLJSBS; CCCtlflTIOIll DISE1SES; BHD10COBIOSIS; IHISS; 1TBPB BOOZS; Eioiccninimoi: nsras; IIBH»TIO«: 1SEISTOS a) Controls b) Residents «ith long tern, high level exposare troe drinking centeniiated «ater Chrysotile fibers latopsies 52-S9 yr old resideats near taconite riocessiag plant, Binaesota. 17-77 yr eld controls. Minnesota and Texas. B11IZSOT1; HUS: 10TOPSIXS: iiiiSTiiis: urn: LOIGS; DSIMKHG IITIB; IKtlDSIBIlI SBISSIOSS; I1DOSTRIH FCIIDTI01; S1TIB tCIintlOI; 15BBSIOS a) inalyzel at Dniversity of Cardiff t) Analyzed by laboratory in Paris Earencaysa ftoa case of pleura 1 scsothelioia lOlISS; ISEZSTOS; IE07L1SBS; CCBFIIITITI ETllOaTIOIS; BK1SUBEREH BIIBODS; FBItCB 33-72 yr olds «ith 1-50 yr occapationl exposare ISBtSTOS; OCCOP»TIO»ll HlZiBDS; 10I6S; IIDOSIBIal ITBOSPflEBES: COST; ItlKt (BUT P»Gl) SIFEBEICK Birsch, a. Bignon, J. Sebastien, p. Candichet, a. 1979 CBIST 76:697-699 Carter, S.I. Taylor, ».?. 1980 Environnental Be search 21:85-93 Sebastien, P. Billon, n.J. Janson, X. Bonnand, fl. Bignon, J. 1978 archives des Maladies Prafessionnelles, de (ledicine dn Travail et de Secorite Socials (Paris) 39(»-5):229-2»8 Biqnon, J. Sebastien, p. Honchaax, G. Btibnaad, G. 197* IISEHB 29:205-218 ------- Ifbestos 1332-21-4 IIACT COBPOSmOl niKSOJI OB BISZTE8BIBBB 1ISSDE JMOSOBS SODTB AIAITTICAL lOaBSB IAIGE \| BEAI \| CBIMI1 IIFOB8ATIOB I BMBBBBCJ BSTHOB 0? CASES 1 1 \| 1 1 3604 IB 1 1.5-3x10(16) ferruginous long bodies/cc 1 1 1 3605 Bicroscopy a) 200,000-700,000 lung fibers/cc b) 85-135,000 fibers/cc 1 1 1 1 I I 1 1 3606 1 I Sicroscopy 5 «4- 7,840 asbestos bodyyg lung 1 1 1 (vet vt) 1 1 1 1 1 1 III 1 III 1 II 1 II II 1 II 11 1 II II 1 II II 1 II II 1 II II 1 II III II I lot given I Intopsy saterial \| Sebastien, P. 1 1 Janrand, B.C. I Occnpationally exposed «6 yr old vith 1 Bonnaad, G. I flenral nesotheliona. \| Gonl, J. 1 I Signon, J. \| ASBESTOS; OCCOPATIOIA1 B1ZABDS; 1 1973 I 10IGS; AOTOPSIBS; BEOPIASBS; FBAKE I Archives des Baladies 1 \| Professiognelles. de 1 t Hedecine du Travail et 1 1 de securite Sociale 1 1 {Paris) 34(6) :335-344 1 1 a) lot given 1 i) (orkers handling rav asbestos b) lot given I r) (orkers nanufacturlng nsbestos I (toduets 1 1 33-16 yr olds, vith various diseases I occupationally exposed to asbestos. \| ASBESTOS; OCCDPATXOIAL BAZABBS: I IDIGS; OCCOPATIOIal DISEASES: I IBTOPSIES; HDOSTBIAl ATBOSPBEBBS; I COST; FBAICE 1 1 lot given I Averages of upper and lover lobes, « I or - 1 SO. Autopsies. 1 1 3 forser asbestos pipe insulation 1 vcrkers and 2 patients vith 1 asbestosls, lung cancer and pleura 1 I aesothelioaa. Ages 48-73 yr. 1 \| ACTCPSIES; CCCUPATTO1L HAZAIDS; 1 IIOPIASHS; DISEASES: ASBESTOS; I TIKIS; \| IICTIT 1 III II 1 1 1 3607 \| 1 Bicroscopy 1 1 a) 1-20 ferruginous 1 a) lot given I a) 41 eases 1 lung II II bodies/cu a 1 b) Dot given I r) 38 cases 1 1 1 1 \| b) 21-100 ferruginous I c) lot given I c) 18 cases II 1 II bodies/co • 1 d) lot given I 4) 3 cases II 1 lie) 101-1000 rerrugiaous I 1 lo significant correlation vith sex III 1 bodies/cu a 1 \| or occupation. of cases vith II 1 Id) >1000 ferruginous 1 1 21-100 bodies/cu a increased after III 1 bodies/cu s 1 1 age 60. • of cases vith highest III 1 1 density decreased after age SO. 1 1 1 24. 7« of cases vith highest density 1 1 1 lived in Paris. 1 Autopsies, 13-91 rr olds, rural and urban areas, France. lelatlonship vith lung cancer eannot r« accurately analyzed because 9M vere snokers. TlllCt: 1COIISCEITS; ADULTS; AGt; AUTOPSIES; nopiASBS: IHIGS: ASBESTOS; ATBOSPRni: BU11B HI! AIDS; 1IBA1ATICI 1 1 Chatel. A. 1 Blgnoa, F. 1 Sebastieo. p. 1 ftlrsch, A. , 1 Bignon, J. 1 Bader, J.-p. 1 Chretien, J. 1 1978 I 2:459-464 1 1 1 1 Soggli. T.I. 1 Greenberg, S.D. 1 Bclarty, J. I. 1 Burst, G. A. 1 Spivey, C.G. 1 Bieger, I.B. 1 1980 j Archives of 1 otolaryngology 1 106:533-535 Bignon, J. Goni, J. Bonnaud, G. Jauraad, H.c. Dufour, G. Pinchon, B.C. 1970 Enviroasental Research 3:430-442 (HIT PAG1) ------- Itbet03 1332-21- IIICT couosrnoi irinofi as OICZTEEHXIED iissdl 3608 lang 3609 lung 3«10 long 3E11 Loag IIPOSDIE iOUTf lageatlon Inhalation Inhalation Inhalation »LT1ICU SBTHCO EH EH Hicroscopy EH WO«BU or cis 33 a] 20 b] 32 1 9 a) 22 b\| 22 O 22 d) 12 e) B fl 1 (USE a) not given h) lot givea a) lot applicable b) lot applicable 1000-10 f!61 ferruginous bodies per en ci a) lot giT b) lot giT c) Sot giT d) lot giT e) lot giT f) lot giT IE11 a) 570.6110(8-5) Cibers/g b) 11«3. 7110(1-5) tlbers/g ish wt a) 46 ferruginous bodles/ag b) 3500 fibers/ag Dry »t •ot given a) 3.7 » or - 1.8 fibers/ng iast b) a. s or - 2.5 Eibers/ng dost _S) SO * oc - 81 fibers/ng dnst I) 171 » or - 201 fibers/Kg dust e) 322 .or - 351 Cibers/ng list () »55 * or - 502 fibers/ng dust GEimL IIPOBHUIOI a) Controls t) lesidents with long tern, high level expoiin froa drinking coataaiaated water CtrvsoHle fiber* 1 1 tops lea S;-8« jr oia residents near tacoaite rcocessiag claat. linnesota. 17-77 11 eld controls, linnesota and Texaa. •XIIESOIa; TIUS: IDIOPSIES; IlttSTUtS: UT»; tDIGS: OBIVKIie Itini; ISDUSTKIII BBI5SIOIS; IICDSTSIil fClLOTIOl; 11TEE IOIIOTI01: 1SBESTOS liter aean length 2.8 a. Bean diaaeter 0.13 a. Hore asphibole thaa chcisotile fibers tulaomary parenchvaa staples. 51 vr old patient. Exposure between age: 13-15 vr in welding factory aad tetweva ages 20-40 vr as electric arc il4er. Paemocoaiosis, bronchitis. Beaiga tcltp on Total cord. long opacities, costophreaic aagle cfcliteratioa, pleural wall thickeaed. rtllCE; ICOIIS; USE HISTORIES: IIOOSTBIH DISUSES; IIOPLIS8S; CCCOTJTIOlll DISUSES; fiioiocaiiosis: imrcs; LTIPB VODES: EioiccointiTio": FIBIIS; ifBiniioi; JSEISTOS tata correlated well with ember of fibers in spotaa. labestos wocters. teao. age S4 vc. 1C1ICE; ID011S; IESPI1ATOBI SICSETIOI: IIDU51BHL HTGIEBE: ISEESIOS: OCCOP4TIOSH. HaZlBCS a) loraal tissue t) Spoataneeac Maathellona c) Occipatioal aesothelioaa d) isbestosle with aesothelioaa e) tsbestoai! with bronchial carcinopa ft labestosis OccapationallT exposed workers. Cersanv 6ISB1IT: lOTOPStES; I»DtJSTBI»L CISEISH: iniSS; tSBESlOS; flBEIS; J1BIHTIOM; CCCOP1TIOIII. BiZlEOS BEFEHEIC1 Carter, BE. Tavlor, i.f. 1980 Envlronaeatal B« search 21:85-93 Hirsch, 1. Eigaon, J. Sebastien, P. Gaadicbet, I. CBSSt 76;«97-699 BigaOB, J. Sebastien, P. Jaurand, fl. C. He. B. 197 Eavlronaeatal Bealth Perspectives 9:155-160 Triedrichs, K.K. Otto, B. 1981 aaericaB Industrial Hygiene Issociatioa Journal 42(2)3150-156 (HIT Pl«) ------- Asbestos 1332-21-* met COIPOSIXIOI onion* OB BBBETEBSIIED (COITIIUED) TISSUE 3612 inng 1 1 1 1 1 1 3613 \| i £rspi> i 1 node \| 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 361* tespirato rr secretion 1 EIPOSniE BORE AIAIRICAL I08EEB IAIGE IEAI I Gllim IlfOllATIOl 1 IEFESEICE t HBTHOD OF CASES 1 I 1 1 1 1 II Inhalation Hicroscopy 21 a) < 0.1-370X10(16) a) «3.27X10(E6) \| a) Dncoated fibers, death fron I Dorgan, A. fibers/g fibers/g \| nesothelial tnnors \| Holies, A. b) 3.a-11SOOX10(E3) b) 1783.7«X10(E3) I t) Coated fleers, death fros I 1980 1 fibers/j fibers/g 1 lesothelial tutors \| British Journal of 1 fibers/g I fibers/g I cancer \| 37:25-32 I fibers/g I fibers/g I cancer \| 1 e) < 0.1-2. 1X10 (E6) 1 e) 0.«SX10(E6) \| e) Oncoated fibers, non-cancer deaths I 1 fibers/g fibers/g I f) Coated fibers, non-cancer deaths 1 1 f) 0-210X10(13) fibers/g f) 28.93X10 (E3) I less than 1* of coated fibers "era < I 1 Dry (t fibers/g 1 10 on long. 10* exceeded 80 an. I 1 • Dry »t I I I lecropsies, 19-88 yr olds. Cancer 1 I cases occnpationallr exposed. Onited I \| Ulngdon. I 1 1 \| \| ASBESTOS: IOIGS; CABCIIOGEI; \| \| \| CCBMMTIU ITllOATIOIS: OIITED 1 \| \| KIIGDCH; OCCOPITIOI »L S1Z1BDS \| II II 1 III Inhalation 1 EH 1 a) lot applicable a) 0.7 ferraginons \| Filer nean length 3.3 o, nean I Birsch, A. \| 1 Bicroscopy 1) lot applicable bodies/sg I dianeter 0.15 u. (tore anpbibole than I Bignon, J. I b) 6, (00 fibers/ng I chrysotile fibers I Sebastien, P. I Dry »t j lediastinal lysph nodes. I Gaudichet, A. 1 1 1 1979 1 1 1 51 rr old patient. Exposure betireen I CHEST 76:697-699 II II ages 13-15 yr in (elding factory and I 111 \| \| letween ages 20-«0 ji as electric arc 1 III 1 1 (elder. I III 1 1 III I Eneanoconiosls, bronchitis. Benign I III I FclrP OB ocal cord. \| III 1 1 III I long opacities, costophrenic angle I III 1 otli tented, plenral (all thickened. 1 1 1 1 1 1 1 1 1 1 1 Inhalation . ES a) 8 W 7 c) 5 1 a) 20-2000 ferriginoas bodies b) 10-20 ferrsgiiKMs bodies c) 0-10 ferrnginons bodies \| FIAICE; 1EOITS; CASE BISTOBIES; \| IIDOSTBIII DISEASES: IEOPLASBS; \| CCCDPATIOI1I DISEASES: 1 tiBtrsocoiiosis: miss; LTBPB IODES; \| EIOACCOI10IATICI: FIBE5S; HB1LATIOI: I A5EISTOS t 1 a) lot gires I a) High risk exposure for 15 rr b) lot given I t) Sod era te exposure for 25 jr c! lot gives I c) Insignificant exposere for 28 re I falnes for spntns 1 I Ccctpatlonallr exposed persons dth I thoracic pathology related tc j asbestos 1 1 Chronic bronchitis in 651 of 18 I stokers and the 2 ton-stokers. 1 I librosls, calcification of pleata. 1 cancer of the Inng or pi Mr a. j lesions of snail airways foud in 80 j at cases. 1 \| ItAlCE: IICOSTIIAL DISEASES: \| KOtLaSlS; CCCIPATIOIA1 DISEASES: \| llSPItVTOtT SKIRIOIS; ASBESTOS; 1 inns: itAHB BIUIBS: IID ------- libastos 1332-21-* tun coBFosmoB imoii 01 oiminmio (CORIIHED) 1XSSBB 3«15 Basplrato ry secretion 3616 lesplrato ry secretlos 3617 Spatan SXFOSBBS Milt Inhalation Inhalation tinmen BET8OD ra Bicrescopy Bicroscopy licroscopy •BBIXB OF C1SIS 2 •t <« b) «2 c) 16 «» 13 b) 16 e) «5 d) 6« Hies a) let applicable b) lot applicable c) lot applicable a) 2-10 ferragiaoas bodies (n) b) 2-300 FI c) 3-1500 FB a) 0-1 85 0 ferrsgiaoas bodies b) lot git ta c) lot given d) lot givea (•JIT BBIB a) 20 ferraginoes bodies/sasple b\| 3 ferzaglaoa* bodies/Maple c) 50.000 fiber s/saaple a) 1 fecragiaoaa body (FB) b) 10 ra c)' 100 IS a) lot given b) 100 ferragiaou bodies c) 10 fetcoginoas bodies d\| 1 feccagiaou bolr Plot) GIIII1L IITOIIHIOI a) latleat 1 b\| Patieat 2 c) Patieat 2. Fiber aean lengtk 2.* i, aeaa diasatet 0.10 a. loce ektysotile taaa aapaibole (ibers Talaea tor sfatas fitieat 1, age 51 yr. Sxposare tataeea agas 13-15 yt in neldiag factory aad fcataeea ages 20-«0 yc as electric arc (elder. Patieat 1, itoker. age !• yr. Ieay erposare ia asbestos ceseat plant, pre-lorld Bar 2. •aeasocoaiosis, broachitis. Beaiga pclyp oa vocal coed (Patient 1) , iqnaaxiM cell carciaoaa of Itryai (tatlent 2) . laag opacities, costopkreaic aagle ctllteratloa, pleeral «all tblcfcaaed. isiBCB: IDVITS; CISB msTOKES: IltHSntU CISUJBS; IBOPUSBS; CCCOVITIOIll DISUSES; (Koaocoiiosis; miss; LTIPB BODES; !io»ccns ------- »tl«stos U32-21- II1CT COBFOSItXOI Ql U»BB«MI».HS (C01TIT7EO) IlSSffJ 3618 Spotaa 3CI» snataa Biposme sour iiiinieiL BBTBOD EB licroaCOBT HIIIBJB OF CISES 1 — — — «__ „. SJ»C! lot given iili eiiuat urossi'ioi 300 ferruginous Occupational!? eiposed, lit. plenral bodies/sasple sesotaelioia 1 I f( jc old (an I 1 ISBtSTOS; CCCOVHtO.al EJ21SBS; 1 .rocs: AUTOPSIES; matusas; tsact I I 1 szrEtnci i Sehutlea, P. Janraad, H«C. Poaaand, G* Gonir J. Pignon, J. 1973 archives 4ea ealadies Piofessiooaelles, de Hedeeloe 4o TcaTail «t de Secarite Sociale 1 (Paris] 3{(]:33S-3« a) 29-523 f iberi/saapla 1 a) lot given I a) Sorters ta-dlig? rav asbestos chatel, 1. b) 0- ------- Enxaldebyde 100-52-7 C7-B«-0 Bl IOC.12, BI -26 C, BP 179 C. ?P 1 •• 19 at 26.2 C irsstii 3621 Breatk 3622 Breatk IXPOSVBB B001Z lEUTTICal BETBOD ec/BS GC-BS »D8B!S OF CASES 9 54 (387 saaples) BJIG1 lot detect ei-1. 5 ttg/ar Bot given Bill 0.2 ug/hr 0.513 ng/1 Geosetric GBIEBal IirOSBITIOI Ccipoiad froi unknown origin. Bo ctker details given cryogenic saspling teckique. Bealtky nilltary and civilian esployees, U.S. air Force School of lerospace Bediclae. ages 23-47 yr. 3 tiokers. EEIZEBES; CBtOBXEaTZB BTDBOC1BBOBS; CBIOHIH oBcanc COSPODIDS; CBLCBOBEBZZBIS; FLOOB.XBE COBPODIDS; EBE1TB; I1CCBOLS; TBIIS; 1COLTS Beaauced at 25 C and 760 ss Bg 2. It occurrence lexer and upper one-Slgaa Halts 0.15) and 1.6« ng/1 Bealtky. 18-35 yr old. nonsnoklng. artan blacks and Caucasians. Chicago, II. Rigidly controlled eiperlnental conditions. tBIITB: IICCEOLS; ItlXBOIS; aDOHS; CElOBUiTID ETDBOCIBBOBS; TOLaTILE CIG1BIC COBPCOTBS; BEallB BlZaBOS; IIBIltTICB; BRIEOLISB; BETaBOLITES; EOPOlaTIOB EIPOSOBI; OBB1B IBEaS BEFEREBCE Conkle, J.P. Caap, B.J. Belch. B.E. 1975 archives of Environmental Health 30(2);290-295 Krotoszynski. B.K. Bruneau. G.fl. O'Heill. B.J. 1979 Journal of analytical Toxicology 3:225-234 Einzena 71-»3-2 CC-B6 >< 78.11, n 5.S1 C, BP 80.093-80.09 C, TP 10 nn Eg at 26.1 C IXSSOI 3(23 Breatk 362» Breatk ElPOSalX BOOTE llUTTXCal BETRCD SC/BS SC-SS IDHBEB OF C1SES 8 54 (387 saBples) Bliez lot detectsd-250.0 ng/kr Mot glren BEal 40.8 U9/hc ».3 ng/1 Geonetzic GE1IBI1 IIFOB11TIOI Prevloas eipcsvre to conponnd. Vo ether totallf given Ctyogealc saipliag technique. BealtkT illltary and civilian eiployees, D.S. llr Force School of leroapace ledlclne, ages 23-47 TC. 3 stokers. tmtns: CBIOBIIITIO HTDBOC»BBO»S: CeiOBXI! O«G»IC COHPOOSDS; CE1CBOBEIZIIIS: PLOOBXI! CCBPOOIDS; EPiHi: iicceois; TEIIS; mtn.'is leasared at 25 C and 760 n* Bq 41.1* ocearrcnce lever aid upper oae-Sigaa Halts 1.6 and 11.3 nq/1 BfaltbT, 18-35 rr old, nonsnlciag. artan blacks and Caucasians. Chicago, II. BigiaiT controlled ctp«rlaeatal conditions. IBEaTB; HCCBOtS; XILIIOXS; IDtriTS; CELOBI11TED ETOBOdBSOIS; TOllTXIE CEGIIIC CCBECTOBS: BSI1TB BH1EDS: IIBlItTId: BETlEOlXSa; BETIBOLXTXS; ICPOLITIOI EXPOSOBE; 3BBal >SEaS EEFEBEBCE Conkle, J.P. canp, B.J. Belch, B.E. 1975 arckives of Environmental Health 30(21:290-295 Krotoszynski* B.K. Brnnean, G. B. ' Ofleill, B.J. 1979 Journal of Analytical Toxicology 3:225-234 ------- Beaseae, cbloro- 1C8-90-7 CI-B5-C1 » 112.58, BF -«S C, IP 131.7 C. TP 10 » at 22.1 C TISSUE 3«25 ireatk EXPOSTSB BOOTI i uitmcn f ffXTBOD OC/HS ETFBZE8 OF C1SI5 8 BUGS lot giTaa-a.OO? a«/fcr BE1I 0.01)03 ig/hr CEIEB1L IBFOSBaTICn Ceapoaal fcoa aaJuton origla. to ether detail* qlnn Cryoaeatc aaapliag teekaiqae. Bcaltkj eilttarr aad civilian aaplorees, U.S. air Fore* School of lerospace Bediciae, agea 23-«7 jr. 3 IIBtBBES; CBlOBtBlTtI BTDBOCUBOBS; CnCBIBI OBG1BIC COBPOBBOS; CELOEOBNKBES: FLBOillg COHPOHIDS: CIB1TB; IICOEOIS; TBtlS; IDVtTS BEPIEEBCI Cookie, 3. P. Caap, B.J. felck, B.E. 1975 IrcklTes of t»iniiaeital maltk 30 (2): 290-295 Emma. «tk\|l- CS-IIO Bt 1»(. 1«. Bf -94.97 C, BP 136.25 C. TP 10 •• Hfl at 25.9 C I 1ISSVS sxtosmy tent t OF C1SIS entiu HFOSBITIOI 3626 I I lahalatlon I I I I I I I I r _i_ I « I I I I I I .1 0.50-0.80 a9/1 0.6925 a ------- fiie, aeiackloro- C6-C1« If 28. 80. » 231 C. tt 323326 C, TF 1 •• Bg at 11.* C IISSVI 3C29 adipose 3630 adipose 3631 Blood niosntE Boott lagestioi labalation Deraal alllTTXCll 1EYIOD ec OC-BC main or CASES 60 a\| 22 b) 1* cl C d) 6 e) 6 11KI 0.23-10.70 ppa a) lot give« b) lot given c) lot given d) lot given e) lot given a) 5-1121 ppb b) 30-9)0 ppb c) 3-600 ppb d) 22-«67 ppb e) lot given Sglt 1.36 ppa a) 0.2* » or - 0.09 •g/kg b) 0.36 » or - 0.2* ag/kg c) 0.12 * or - 0.06 •gAg d) 0.08 «or - 0.07 e) 0.09 4 or - 0.03 •g/kg a) 310.7 * or - 287.7 PPb b) 311.5 » or - 22.9 ppb c) 159.9 t or - 12.7 PPb d) 170.3 » or - 111.8 ppb e) 0.1 * or - 0.6 ppb Ctmil IIFOIBITIOI Feripheral tidier fat. roatlve pathological •xaaliatloas Iges 6 IO-92 it. Belgian BHBIBI; 10TOPSIES: IDIPOSE TISSUE; tlOaCCOROllHOI: PESTICIDB3; DID: IK; OBI; DIUOEII; HBPT1CB1CB IPOIIDI; BIIICB10BOBZBIEI1; III CUE; CBIOBIIB oiemc COBPOOIDS , •1 Ilderlr icn b) BlderlT «enen c) Toiiq IB ) Bevborns crlrenal tissae 176 survey. •topsles frei 3 donor groipa. v«rage ages 70 "vr. 2 yr. and 25-35 \, Oslo, lonaj. ItltOSB TISSBE: BILK; COHPlilTIVB IflLOiTIOIS; IOBIII: IDOItS; iVTOFSIlS; IIW8O1I; CnOBIIlTED BTBBOCISBOIS; IDT: PBSTICIDBS; ICITCBtOBIIlTtO BIPIMYtS a) SO exposed vorkers. 197* b\| 9 exposed corkers, 197S c) 9 exposed vorkeri. 1976 dl «* exposed vorkers. 1977 e) ** controls. 1977 a)-d) aaalrzed by different lafcoratories. laplorees of a chlorinated solvents plait in Ibcrillle parish. 11. 197-1977. Controls worked In a polyethylene prediction plant. Be detected dif fereaces betveen exposed and controls studied in 1977. BIIICHIOBOBEHBB1: NI6ICIOIS; BLOOD; IICDSTIIU. FLUTS; OCCOPITIOHL iiziiES; let: siciiL STUDIES; iiinsTiiii iTHospBnis: iionsniit JICIEIB; COBPU1TITB EY1LU1TIOIS BIFEBCTCI Dejoaekheere, I. Steirbait. 1. Terstraeten, B. Rips, I.E. 1978 Toxicological European Research 2 (2): 93-98 Brevik, E.R, Bjerk. J.B. 1»78 icta Fhariacologica at Toxleologica •3(1)8 59-63 Carrier, I.F. •cCliians. C.D. Bana-lloyd, 6. 1980 Joarnal of Toxicology aid SivironMBtal Bealth 6:367-377 (HIT fjtet) ' '" OJ ------- CcnzeM, aesacaloro- ce-ci« 1< 28. 80. K 231 C, BP 323-32* C, »P 1 u tg at 11. C IISSO! BIMSOIB iOOTE UllTTICtl B1TBCD 3632 00 K Blood, ibol* 1 1 1 1 1 1 1 3f33 1 Bilk 1 1 1 1 1 1 1 1 1 \| GC-EC SC/BS 1 363« (Ilk 1 1 f 1 1 1 flTSBES or cises ) 35 b\| « a fUGS a) 0.1-3 ng/g b) 0.1-1 ng/g .6-17.1 ng/kg 1 1 I - - - Bill \| GBIrBII I»TOBB»TIO« 1 BKnBEXCX I \| 1 1 a) 0.6 ng/g \| > lore cannl reaidenta, 100T ( Bristol, B.I. b) 0.3 ng/g 1 to«lti»e caarlea 1 lego I b) Tolnateer, 10M positive aaaples I IPI-600/1-80-036, 40 1 Halt at aeatoreaent, 0.011 eq/y \| pp. 1 ClctelT aatctol, siaqltaaeoai control I 1 aBl«< vere not pcovttod tor 1 1 ialyU along «lta those froa the 3 I 1 Icve Canal area residents aaapled. I 1 lacking aeacingf ol control ot I 1 llteratare data relative to tbe 1 1 ctgnifieaac* of the lo* r«»ldne» I 1 foand la tie field saaplea analrr»d, I 1 no definite conclnslons can be dran I 1 fro* tan reialta reported. ( 1 1 1 I««ldents ot >•* lork. Controls, I 1 eaploye** ot the Zsvironaental 1 1 Protection Igeacr and oalveratltT 1 1 «tndeot». Berth Carolina. 1 1 1 t «!« TOSH: IOFTH CUOIIll: EICOD: 1 1 Btismnm Brrsons; CBIOBIBE OSGIIIC i 1 CCBfONBS; CBIOFOBBIIIIBS: 1 1 ItllCnOlOBtKEBI; POirCSLOSMJTIB 1 I HPBiiiis; pcpoiairoi Bifostjsr i 1 1 1 1 .9 «g/kg I Uctatiag aetbers 1 Sodrlc-Snit. R. 1 1 salt. -L. \ 17-41 vr olds fro* Slavonia Province, 1 oil, X. 1 Yugoslavia. I I960 1 1 Pesticides Honitoring 1 locosmn; uctalioi: Kin: i journal 1(1>:l-2 1 iiotccmnKio* ; BBUI aa»s; i 1 CKCtlMTEC BTBBOC1EBOJS; C BIO 8MB I ( CEGMTC COHECTTSDS: CHIOJOBSIlrBtS; 1 1 tIE: DDT; BinCBIOBOCTC£OB»IBB: 1 1 HSTICIDIS 1 1 1 ec-BC I a) 14 aj ot girt a) 5.5 • or - 3.7 a) Oslo, large iadusrrialiled city 1 Brer Ik, E.a. 1 b) 11 b) (at girea no/kg t) Berqea. large iada»trialin>a city I Bjerk, O.B. O 10 c) lot giren » 9.2 « or - 4.0 c) Barstad. saaller dtr vitb large I 1978 6J 9 &) Bot given ng/kg cbealcal/petrochealcal complex 1 act* PbarMcolo?lca et c\| 2. 7 + or - t.O d) Porsgrana, aoa-lBdastrielizod' 1 Toxlcolo?ica ag/ltg flaking coasmity 1 3(1\|:59-«3 i) 3.2 « or - 1.2 U7« sarnv. Significant difference 1 ng/g (f < fl.OSI tttveen saapllag lte»: I EC r gen > Oale > Barstad, PomgcuiB 1 t looegian aether, ages 25-28 ir. f 1 ICIP05I IISSBE; «n.K: COBPJSlTIfF I I cmgiTiois; IOKIIT; tcans ; \ 1 IttOPSIBS: BHBOIB; CBtOBHHED I 1 BUBOCtlEOBS; DM; PISTICIOIS: { i i fcticaionmiD fiPBfins i 1 1 1 1 ------- It ami, o-aickloro- (8 CI) E«I»M. 1.2-aickloro- (9 CI) CC-B«-C12 S« U7.«, HP -17.5 C, Sf 10-183 C, T* 1 « Bg »t 20.0 C TISSUE 3«35 Btaath BiniOBS BOOH iiitnicii BRIOD 8C-BS •DBBM OF CaSIS » (387 IIICX lot gl« 1EII 2. ng/1 Seoaetric SEiitiL nrotamoi Masnct at 2S C ana 760 a* Bg 13.91 oceimnc* lovtc aa «pp«r one-Sigsa Haiti 0.«3 aaa 13.5 ng/1 Kalthr, IB-IS TC old. aaaanktig, attaa blacks ana Caucasians. Chicago, II. Bigidll conttoll«d . Obi, 6. 1975 EBTironaantal Pollntioa 8:2««-274 ------- Mama, p-ajckloro- (t cxt mm. 1,1-M.cklora- f» «) 1M-M-T ee-t«-ci2 II 17.01, It S3 C. W »7«.« C, Tf 10 M tg «t 5.« C TJS3BS 3S38 flood. • boll 3639 BMatk xuosm om Inkalatio I uitmcu. imoB 8C 1 I IK- as tmtst or C»SB c M per •UplM) 1MSI •-16 »g/»l •Ot 9iT«l IUI 9.5 »g/«l 1J.« ««/i ea»t£ic czitui inoiMtioi IWltkf J ll «t 2S C «»a 7<0 » M »t.« occ«ci:«c« tewr «»4 BFp»r aD-sl4M licit* ».t lid J«.3 «?/l I«althr, 18-35 Tt oW. non»oti«q. it tin blacka Md csteuikB. Ckleago, n. Hflldly emtroUcd «ip«rlM>t«l condlticua. (I»T«; HCOtOU; IUIVOIS; IDU1TS; cnciiuiie miociiBois; »ot»rn.e CSSIPIC cowcnD5: IUITB miBos; HBJiiTici; maeoiisa; SITJKHITBS: FCCIIIIICK EITCSVn; OlUt SU3 nnma Borit«, S. Oki, 6. 1475 z>Tiroi»«Bt«l Fellatio! 8l2«»-27» troto«T»ki< B.K. Era, S. S. O'KUJ, H.J. 1»7» Jooreal of Unljtictl loilcologj 3:225-23 t«MM. fntackloco- ce-»-ci5 » 250.3. Bf 86 C, IP 277 C 1 IISSO! 1 • 1 1 3MO Bilk 1 iiFOsaii IOITTZ 1 « 1 I 1M1TTIC1I I BVTH00 t t i eoic t OC/TIS I I train i or csi5 i i 1 6 1 1 1 \| 1 11KI 1 1 1 0-3.4 «g/t-j 1 1 t ' 1 atti 2.0 ng/j 1 Gtitiii nrotaiTioi 1 I tictttiiq ietk«t 1J-»1 fr olds fro* SlaMiia (rotlic. I«ol«ri«. TCCOSHTll; ItcIlTIOl; Silt; BJOICCOSOIITIOI; IDIU U»S; CKenntn mBoctiBois; cnoim cienic coatents; cnmoBiizsus: tti: on: nxicnoMcrcioMUit; fISTICIDIS Kninrcz Io ------- ftate«e, peitacaloroiitro- 82-CI-8 C«-C1S-C-02 HI 2»S.«. BF »6 c, BF.328 C. It 0.013 •• Bg at 25 C 361 Blood, •bole ElfOSOR BOOT! 1U1TTICU BBTBOD OC-EC miBEE or cuss a) 35 b) 11 MICE a) lot applicable b) lot dttacted •Ell a) 0.2 nj/g b) lot detected CBIIBII IirOBBHIOI - a) Love Cagal reaideats, 3* (1) tctitive b) volonteeri lean of positive saaples. Llalt of aeasareaeat, 0.1S ag/g Closely aatched. sinltaneoas central saaplei vere not provided for aaalTSis alaag ith these free the 36 love Ctial area residents aaapled. lacking seulngfnl control er literature data relative te the significance of the Ion residaes feind in tbe field sanplos analyzed. ao definite coaclvsloas can be drain fios the resells reported. Itsidents of lev York. Controls, eaplovees of the Environmental Iiateetiea leaner and wtlveralty (tadents, lorta Carolina. Ill YOHKs IOITB CUOlIIl; BLOOD; ItlSgiNBII IETBODS: CB10BIIB OBGaRC CCBFOniDS; CBLOBOBIIZSIES; IIIICBlOlOBEnEIS: FOLICHlOllmBO IltltlTLS; POPOL1TIOI SZCOSOBE BEIXBEICE Bristol, D.I. 1980 EPI-WO/1-BO-036. ao pp. Baana, propyl- 103-65-1 C4-I12 II 120.2. If -99.5 C. BP 139.2 C, TT 10 •• H« at «3.» C 36«2 Breath IUOSHIH SOOT I 1HIITIC11 BBTBCn 0C/BS •OIBES or CISBS a tllSE lot detect «d-6. 5 ag/hr mi 1. 1 ag/hr " 6IIII1L IIPOBB1TIO1 Ceafonad related to noraal ••tabolisn. lo other details given CrTogeaic sanplinq tecbnigee. Bealthy ailltarr and civilian eiplovees, O.S. air Force School of lerospace Hediclne, aaes 23-»7 vr. 3 aaokers. EIlZEIfS; CBIOBII1TED RDIOC1BBCIS; CIIOIIIE OIGHIC COIPODIDS; cncMiNZBiis: rtnonii coipoms; fltlTB; alCOBOlS; tBZIS; 1DH1TS BEIESEICE Coakle. J.P. Canp, B.J. nich, B.I. 1975 archives of IiTironnental Health 30 (2): 290-295 ------- IJSS1-13-7 C9-B12 » 130.2. » -2!.37 C, BP 576,1 C. V* 100 •• Kg at 108.8 c tissn 3««3 Cnatk nfOSOBB BOOTS iiUTTXcat BMBOr EC/IS Btnuxi or cuss 8 met lot d«t«ct«4-9.3 ag/ar nil 1.2 ag/bt CZHMI nroBHiiar Compound fiei aakaon origin. la ctkct fetalla gi»«n CXTogvilc aaipliag teebaiqw. Maltkr •ilitwr a»J cirili.B • •plor«<, U.S. lit Fore Sckool of l«Mp«c« RcUclM, <9«s 23-«7 jr. 3 ••okcrs. Zfl»»S\| CBtOIIMTZO BtOSOCIfiBOBSj cnoim atcinc cocfomos; C81O10BH2II1S; nocim caimnos; tuiTi: ncoeoLS: THIS; loans nnum c«n>kl«, J.P. C»p, B3. »lch, B.I. W75 »rclil»«« at XmrlrauutU Mlltli 30 {2)1290-295 l«0-«7-0 C1-B5-I HI 103.1. IIP -12.8 C, BP 191 C, 11 1 M 84 l coaUtloaa. I \| IBftTB: ilCCBOlS; H1IK113; JOOLT3; \| tnOHBlTIC (IDBOCtSBOIS: TOW Tin I cismc coBFcmtis: BMITB ginms: \| KEUnlOB: BRaZOLISB: BEHPOLITIS; 1 pcftniTioi ttnsns: aisn »BIJS • tErnncx Krotonyaaki. B. E. Ecoaaav, 6. a. O'Baill, B.J. 1979 Jaanal of analytical Toxicology 3:225-23* oo £«»irl«aiB« (8 CI) e«axMMtaataiim (9 cl) 1CO-W-9 C7-B9-B ft 107.2, BP 18- C^ If 1 mm Bq at 29.0 C X1SSVE 36«5 Bmth SXCOSOB5 1OOTB IBllTTlcal HTBOO OC-BS or cisss S» R8T caapl^sl Eire! lot giT«a BUI - 0.007 ag/1 Scoavtlie 1 GEItBlt nroiBlTIOB Kaaatad at 25 C met 760 aa Bq 12.94 oecarraae Ic««r aa8 tpj«t oaa-Sigaa lialta C.0015 aad 0.0327 aa/1 Btaltky, 16-35 yr oU, aoaaaoliia. «tttn blaeka aal caicasians. Olcaqo, II. HigillT coDtrjll«4 ------- leryiitai 7«0-t-7 fc Itl 9.01211, tl 1287 C. BP 2500 C. W 1 •• Hg at 1520 C, 10 aa Ig at 18(0 C IXSSOI 3S«6 Blood 367 Oriae IltOSOBI MOT! lULTTICJl BBTBOD us us •01 BIB or cisss 10 a) 2 b) 8 BIKE lot given a) lot givea b) lot givea BUI 1.0 or - 0.% ng/g a) 0.9 * or - 0.5 ag/g b) » ng/g 61IIM1 IirciIlTIOl Ceatrol valaes. Increase by factor of * for eiposed groap. 1 persons nocking -6 kc daily in at«a vlth Bacl2 leakage aad 2 non-exposed controls. Federal t«{iabllc ef Cersaay. CHiiiT; EiocD: DBlii; BiBiuins; miLS; eoiomioi iirosoFl; B»TS a) Coatrola k) Ixponfl gtovp. leak at 4»T»« •>ti«ate4 frea graph. B«B «orki«g «-« br daily in area with I«C12 l«akag« and aoa-«zpo8«d ceitrols. federal Bepablie of Scraaar. GIB1JUT; BIOCD; DBIfE; BEBT1LIBB: inns; popotiiioi ncosoBi: BUS BIFIBZfCI Stiaf«l. t. Schnlxe, X. Zornf n. Tolg. S. 1980 irchiTes of Toxicology •5:81-92 Stiefel. T. Schulze. K. lorn. B. Tolg. 6. 1980 Archives of Toxicology •5:81-92 ti;k«iTl (8 en l.l'-Blphwjl (9 CI) 92-52-» C12-B10 BI 151.2. tt 70 C, BP 255 C. TO 1 aa Bg at 70.6 C TISS1I 368 Breatk BirOSUBB BOD1I 1HLTTIC11 SSTBOB SC-BS IOBCEB or cisss 5» {387 aaaples) »I6B lot given Bill 0.032 ng/1 Geometric GUlBiL IIFOSa»TIO» Icanred at 25 C and 760 aa Bg 2C.74 occacrenca lever aad nppar one-Sigaa liaits 0.0096 aad 0.109 aoyi Baaltkr, 18-35 TC old, nonsaokiaq. artan blacks and Caucasians. Chicago, II. Bigidly controlled eipcrlaeatal conditions. EBIJTB; UCCEOIS; IIIIIOIS; tDOITS; CEICSIHIIEO BIDBOC1BB01S; fOLlTTLB CBGinc coitcniDS; HIILTB Binsts; IlBlltTIOl; «R>EOIISfl: BITiEOlITES: tCPOUTIOH UPOSOBE; OBSiS »BE»S EErilEBCE Krotoszyoski, B.x. Brnaeaa, G. B. 0«»eill, B.J. 1979 Journal of Analytical Toxicology 3:225-23« vD tiphenjl. ciloro (8 CI) I.l'-Biphenyl, chloro derits (9 CI) 1336-36-3 IIICT COSPOSITIOI DIKIOVI OS OIEnZBBIBZD TISSDB 36«9 Idipose BTPOSOR! SOOtZ 1U1TTIOI HETBOD GC/HS BHBEZB or cisss 16 ClIGB 1.6-3.2 ng/g (fat basis) CE) GZIIBaL IBTOBBITIOB faaples frea hospitals and aedical exaaiaer's office in Tokyo. JltlB; «»IFOSE TISSUE; BLOOD: CBICIOBIBZIIIS; PESTICIDES: EcucBLoauniD EIPBIBTLS; IIHOSPHEBE fEfEBBBCE Borita, B. Ohi, G. 1975 EnTironaental Foliation 8: 269- 27 ------- Mphenyl, chloro (8 CI\| .I'-Blphenyl. cbloro aerivs (9 CII 336-36-3 UCT coBPosmoa OIIIOVB OB OBDETEBBIBED (COBflBtTBD) iissnt 3«5« laipose 3651 adipose 3652 Idlpose 3653 Blood BIPOS0HB BOD1B aEaLTHCU BETBOD _ ec-Ec OC-SC EC- EC B03BBS 0? C43SS a) 33 b) 1 c) 1 a) 22 b) 14 0 6 a) e e) 6 O 36 2 BlBSB a) Bot given b) Bot given c) Bot given a) Bot given b) Bot given e) Bot given d\| Bat given e) Bot given a) Dot given b) Bot given a) <0. 5-8 ppb b) 1-22 ppb c) 1-12 ppfc a) 1-12 ppb e) 1-18 ppb f) 1-23 ppb BEaB a) 2.6 * or - 1.90 ppn b) 3.2 ppn, fat basis c) 4. 2 ppa, fat basis a) 2.14 * or - 0.86 •o/kg b) 1.65 « or - 0.83 •g/kg O 0.92 » or - 0.38 ag/kg I) 0.63 • or - 0.53 ng/kg e) 0.90 » or - 0.42 •g/kg a) 200 ppa b) 600 ppn a) 3.0 or - 1.5 ppb b) 3. 5 or - 2.3 ppb c) 3.8 or - 2.0 ppb S) 3.7 or - 1.9 ppb e) 3.3 or - 1.9 ppb f) 3.1 or - 2.3 ppb GBBtBll lEfOBslTIOB a) Bospltal catlenta b) 13 vr old resale «lth lasho e) 46 vr old nale eitb chronic PCB cottoning Japan IClICcTOBIBlTID BIPBIBYLS; DDT; BIUCRlOIOCTCLOamEB; BLOOD PLaSBA; Bionisas; Jipai; saSTBOifiBsnaii. SISTBB: FISTICIDBS; UIPO5C IISSOB; U»tB; KIDB1IS; OBEBTOB a) HderlT nan b) Ilderlr icnen c) tonng aen tf) Toong voien e) Bevborns lerlrenal tiesae 197C sarvev. Significant increase in elderly conpared to 1969/70 survey. letopsies frcn 3 donor groups. average ages 70 vr, 24 vr, and 25-33 •k, olso, Borvay. ICIPOSE IISSOE; BULK; COBPIB1TIIB ITtlOITIOBS; BOBilT; ADtltS: lOtOPSIBS: BEIBOBB; CBLOBIBATBD B1CBOCIKBOBS; DDT: PESTICIDES; ICllCBtOBIBIIID EIPBEBILS a) Sanple 1 t> Sanple 2 Cose and origin onknovn Eata also foi 6C/HS, identltying PCBs (ran pentacbloroblpbenrl to d«cachloroblchenTl, at loaat 1» isosers and cl analogs JCKOSE TISSOB; BEaSOBEBBn BBIBODS; IOITCBLOEIB1IID EIPBBBILS; eioiccoainnoB; POPOLITIOB EIPOSOBB a) 1972. 129 sanples b) 1973, 123 sanples c) 1974. 117 sanples 0} 1975, 113 oaaples e) 1976, 100 sanples () 1977, 101 sanples Concentrations highest in 1st parity nctbers. 180-141 laetatlng voaen, 2 souths after delivery. Besidents of Osaka Icefeetnre, Japan, varied diets and JIPIE; t»CI»TJOB; BLOOD: BIIK; EioiccnanitiioB; PESTICIDES; ECITCBIOBIBIICD BIPBBBnS; OBGtBIC CEIOBItE COBCOHBDS BETEBEBCE \| I Inoae, 1. kbe, s. Takamatsn. a. 101. I. Blkl, s. fojlvmra. K. 1S75 raknoka Bodies I Joarnal 66(10:610-616 Brevik. E.B. Bjerk, J.E. 197B Icta Pnarucologica et Toxicologlca 43(1) 159-63 Biros, f.J. talker. I.e. Itedberr, 1. 1970 Bulletin of Znviromeatal Coataniaation and Toxicology 5 (4): 317-323 Takasblji, T. vatanabe. I. Knvabara, K. Tosbida, S. KayaDja, K. Konlta, B. 1979 International archives of Occopational and Envlronaental Health 43s 1-15 (BEIT PlGE) ------- fipheeyl, chioro (8 CI) .I'-Bipkeayl. chioro derive (9 d) 33C-3C-3 HCI COBPOSITIOE OinOIB 01 OHITMRIHD (COBTIBDZD) jjjSjf - - — — - 36M Blood 36SS Blood 3«5« Elood 3«57 Blood 3658 Blood. plaaaa IIFOSO1B BODXI Ingestion Ingestion IBURICU BETBOD OC ec GC-BC ec ec BVBBBI or cisss a) 17 b) 16 37 66 a) 2 b) 15 e) 2 d) 37 a) 30 b) 18 0 11 BUM a) <0. 2-12.8 ppb b) 1.7-4.6 ppb a) lot given b) tot given c) lot given d) 1.25~« ppb e) 1.8-0.* ppb 11-720 ppb a) 3-26 ppb b) 2-11 ppb c) Bot applicable d) 1-7 ppb a) lot given b) lot given e) lot given BE1I a) 3. 8 + or - 3.6 ppb b) 2.8 + or - 0.8 ppb a) 3 ppb b) ». 8 ppb c) 2. 55 ppb d) lot givea e) lot givea M ppb a) 9 ppb b) « ppb c) 2 ppb 1) 3 ppb a) 6.0 ppb b) 10.8 ppb c) 3.7 ppb CBItllt IIFOTB1TIOB •1 1 10-6 yr olds t) Bothers of children Children* s blood level varied »ltk length of breast-feeding. lesUents of Osaka, Japan. Bothers eith no occa rational exposure to KB. fClTCILOtlBltm BIPKEBTIS; BILK; BIOOD; CRIltBEl; POODS; PESTICIDES; JlVftl a) Bothers. 8 so prcpaxtna. 1977 b) Bothers. » ao prepartaa. 1977 c) Bothers. ; so postpartoe, 1977 d) Breast-fed infants, birtk and 1 yr. rinal valne 1.7 ppb at 3 yr O Bottle-fed Infants, birtk and 2 yc. riaal Talae 0.5 ppb at 3 yr lalaes froa graphs, other data for 17 aornal pregnant eoaen. 20 infants. tOlTCBLOSIUIIO EIPBEITIS: 1CTBOBI; IIE6IMCT: JU1B; BIOOD: BILK: 11CTITIOB latleats vita skin disease cansed by rice oil contaninated vitk highly-chlorinated PCBs. Tested 9 ic-1 yr after Intoxication. laieaa CItOBIBl OBG11TC COBPOOIDS; EIPHHTL CCBPOOWDS; foOD COIT1BII1TIOI; CBII1; Sill DISElSIS; BIOOD a) Patients - gas ehroaatograa (GC) patten peculiar to ynsho b) Patients - GC pattern siailar to a) c) Patients - GC patten siailar to d) d) controls significance of similarities not dlccossed i> English abstract. lasho patients, nornal controls JiPii: eioot: BiPHEin cosronws: fOITCHIOHllTID EIPBEITIS; POPOllTIO* I1FOSOB! a) lasho cbildrec t) Bothers vho coasaaed ECB-contaaiaated oil c) Control children. Exposed aothers. their offspring, and eentrols la Japan. Ciarrkea. physical dullness. ationlnal pain. fClTCBLOBIHTID EIPBEITLS; BIOOD CIISBI: JIPII; rooo COITIBTIITIOI; CBIIDltl (HIT PIG!) BETIBE1CE Knvabara, K. yakashiji. T. latenebe, I. Toshida. S. Koyaaa, K. tanita, I. 1979 Bnlletin of Eavlroanental Contanination and Toxicology 21:58-«62 Kodaaa, B. Ota, H. 1980 Icchives of Environaental Health 35(2):9S-100 Chen, P.B. Gav, J.a. Wong, c.K. Chen. C.J. 1990 Bulletin of Environaental Contanination and Toxicology 25:325-329 Basnda, T. Kagava, B. ShiaaaaEa, I. Takada, B. Karatsnne. B. 197« raknoka Bedlcal Journal 65(1): 25-27 Jbe, s. Zaone, y. Takanatsn, B. 1975 nkaoka Bedical Joaraal 6(10) -eos-609 ------- lr chloro (8 CI) l.t'-BlphCBTl, chloro derits (9 CI) 1336-36-3 coBFosmoi vEinoni OB n»rmEBi»ED (COITTIOED) TISSUE EIPOSIJBE SOOT I alalTIICll BtUIES B»GE HE1B GEBEB1L IBTOBHTIOB I EIIEBXfCI BETHOD OJ C1SES 1 I 3659 GC a\| 82 a) 1-7 ppb a) 3.0 * or - 1.3 ppb a) Controls 1 Takantao. B. Blood, b) 15 b) 2-15 ppb b) 6.3 » or - 4.0 ppb b) PCB-polsoned patients \| I none, I. • Plasaa t Ibe, S. EIPBIJH CCBfOUIDS; CB10BHI OBG1IIC I 197* CCBPOOIDS: Eicon ; BLOOD PLISBI; JJPM I Foknoka nedical Journal 1 65(1):2S-31 1 1 1 1 1 1 3660 1 a) 33 Blood, 1 1 b) 19 alasaa 1 1 c) 30 1 1 d) 1 1 «) 1 1 ft 1 1 1 t 1 1 J I 1 r 36«1 I BC a) 107 Blood. i b) 151 plasaa 1 c) 166 1 1 d) 192 1 1 1 1 III I 1 1 \ t t t f 1 I 1 1 1 1 1 1 \| i 3662 1 1 OC Blood, ( 1 (bole 3663 Blood, •iole 3«6« Kidney 9C 6 a) 11 b) 25 1 a) fat given a) 6. 1 * or - 3.52 a) Hospital patients \| Inooe, T. b) lot given ppb b) Znciated persona \| ibe, 5. c) Bot given b} S.4 + or - 4.26 e) (bn-enaciated persons \| Tafeaiatsu, B. d) Bot given ppb d) 24 yr old aile »ith aplastic \| lofci, ». e) Bot given c) 4.7 » or - 2.17 aoenia and stoach caacer , mid, s. f) Bat given ppb e) 73 yr old nale with colon cancer I Fnjivara, It. d) 92 ppb f) 13 yr old fenal* with Tnsfco I 1975 e) 230 ppb \| rakuokn Beflical Journal f) 5 ppb Japan \| 66(10:610-616 EOITCraoBIIlTIB BIP8EBIISJ DDT; I BEX1CBI080CTCLOHEHBI: 3LOOD PL1SH1; \| BIOPLISSS: JU1B; S1STBOIIIISTIML I STSIEIf; PESTICIDES; 13IPOSE TISSUE; \| I If IB; KIDEET.S: OBSBTOB f \| • a] 0-20.6 pfb a) 0.3 ppb a) Baral blacks r Finklea, J. b) 0-29.0 ppb b) 1.9 ppb b) Urban blacks \| Priester, 1. 1. c) 0-220 cpb c) 2.3 ppb c) Brbaa Caucasians \| creason, J. P. d) 0-16.6 FFb i) 3.1 ppb d) Bnral Caucasians \| Banser, T. 1 Biaoers, T. t \| Orban ana rural residents of sc, t Banner, D.I. 1 Infants, children, adults, elderly. I 1972 1 1 Jnerican Journal o I SOUTH ClBOLIBl; IBDtTS; CBILDBEB; I Pabllc Bealth I IKIal STUDIES: BLOOD PLaSBli 1 62 (5» : 65-651 \| CCBP1SJTITB IT1L01TIOIS; ODD; DCZ; I I CCT; CIJLDBIB; PESTICIDES; \| 1 ECETCB1OBII1T1D EIPHEEILS: UB I I iciiVTioB; rcoo coiriauiTioH: i 2.2-4.0 ng/nl ) 1-6 ppb ) 1-12 ppb ot applicable 1 PESTICIDE BI5I9UES: POPDL1TICH ) I IIPOSOBE: BOIU IBEaS; OBB1B 1BI1S 1 1 1 2.9 ng/al I \| gorlta, B. 1 1 Obi. 6. 1 Bealthy Japanese, aqes 21-35 yr. I 175 I I Environieatal To lint log I JIEIl: 10IEOSI TISSII: BLOOD; I 6:269-274 \| CBLCBOBEIZIBtS; PESTICIOZS; 1 I ECITCHLOBIR1TED BIPBEBHSJ ETBOSPBEBE I t 1 1 1 a) 2. 8 « or - 1.5 ppb \| i) controls \| Takasatsu, a. b) . 8 » or - 2.9 ppb \| b) ECB-poiscwl patients 1 Inane, I. 1 f Ibe, s. 1 EIPBIBTL OOBPOHEDS; CBLOBIBE OPSIITC \| 1974 I CCIPODIOS; Biooc: BLOOD PLISBI; Ja?ll I Pokaaka Bedical Journal 1 \| 65(1): 21-31 36 ppm (fat basis) I 34 yr old (ale with aplastic aneni \| Inone, T. 1 aid stoaacb cancer I Ibe, S. 1 I Takaaatso. R. 1 Japan \| loki, f. 1 1 Biki, 5. 1 tCITCRlOIIIKID tIPBEJTLS: DDT; \| Tu1l«ira. K. \| BIIaCBLOlOCTClOBnHI; BIOOC PLISBI; \ 1975 1 lIOfLtSsS: J»»; G»STBOI1TESTI«IL I rukaoka Heiical Journal I £1J1»8; fSSTICIBSS: UIVOSS 11 S SOT; \| SI (10s« W-616 t mis: nmis; OBHTUS \ 1 > Ul ro ------- Eipbenrl, ehloro (8 CI) I.I'-Blpaeiyl, eklaro derivs (9 CI) U3C-3C-3 tiici COIPOSITIOI imtxNi os (CORII0ED1 HSSfll 3« 9 a MUSS lot applicable «) lot given b) lot given c) lot given 4) lot given a) lot ilven b) lot given c) lot given d) lot given <0.0-0.1 ppl inn Hit TO ppa, fat basis a) 612.5 ppb b) 680.0 ppb c) «82,5 ppb d) 5)0.0 ppb Fat basis a) 2» or - 9 vg/kg b) 2» » or - 9 ilf/tg o) 29 » or - 8 ag/kg fl) 19 * or - « 19/kf 0.05 ppa P1GE) GIltUL IirOEBaTIOl 2« TE old tale «ith aplastle >•«•!& tti stesaea cancec Jp» ICltCBLOSJiniD nPHCTTLS; BDT; DiiiciLOBocictoEnaiE: BLOOI Piisaa; izociisia; 4ipi«; O«SISOI»TISTIUI. 3TSIE5; PESTICIDIS; IDJSOSI HS3HJ; tiTtB; Kitiiis; CHITHI! i) 1 wntk b) 2 laithl c} 5 loathe 41 T untie Uter pactnltlon i« 19T3. Estlcated ftea qcapk. lecul, pceqiant «ose> In Japan. ECtTCILOIIIllfO EIPBWTIS; lIBBCBi; CItCIllCT; JIP11; BtOOD; VOX'. IICTITIOV •> Oslo, Ittge iBdistrlillxci city 1) lerqea, large IndastrlallxeA city c) latstal. JMllit cltr >ltk lar?« ch«ilc«Vp«troclie»ical coatl«r 4) foraifrnnB, non'ln4astclallzea (iailiq cotatnit; 1576 »act«7. si quit leant Increase (P < O.OS) In Oilo, Bergen, and Barsta4 eaaplat e««pared to a 1969/70 s«Tey. lemqlan aethers, ages 2S-2S yr. ItlPOSB TISSUE; BHX; COHPIIITITE IllLUlttOlS; IOBB1T: tBOtTS; IOTCPSIBS; ItlBOBR: DOT; CEtCBISlTEB ETESOClBSORS; PESTICIDES; ECITCEI01II1TID miEITLS t«Tin of bleloqical inpact of PCBs en breast-fed infants and r«coai«nattions far nrstnq nothers J1P1I; IBNTS; IinnS; SKIi I1SE1SES; RIIK; BtflCT; ECtTBIOIIllTID BIPSIiTLS; ECITCHtOIIIlItD BIPBMTLS; EI01CCHBVlIIO1l; nRE EETISDlRIS; fCCE CORJBIIHIOf: TOOOS; HCTITIOH; tCPQUTIOI IIPOSOE! 8iab«st 2 levels In boose* lies «ho bad navec lived ostsiie Colcrada. H-2« yz olds In 2 Colorado eonniaUles vitn popolatlona of about •5,000, prisarlly aqrlcaltacal, ligtt irdnstcr. CCLOB1BO: 1EI1TS; IULK; EOIICB!.OB1«»T!D EIPHHTLS: KVOLHIOI IIPOSV1E; BOIU HX»S _ SEfEBEIC! Inoae, T. »be, s. TakaMtsn, a. aoki, ». Riki, s. rnjivar. K. 1975 raknoka Radical Journal 66(10:610-616 Kodaaa, R Ota, R. 1980 Irchives of EnvlcanneDtal Health 35(21:95-100 trevlk, I.H. Bjeck, J.E. 1976 let a PnarMcologica at Toxicologica «3(1):59-«3 Biller, S.I. Tinberg. L. 1977 Journal of Pediatrics 90 (3): 5 10-512 Savage, E.P. Tessari, J.D. Ralber?, 3.9. Vheeler, H. v. 1973 Bulletin of Environmental ContHiaation and Toiicology 9(«):222-22S Ln OJ ------- ti;k«BTl. chloro (B CI) 1,1>-Bipk««Tl, chloro aarlTS (9 CI] 133S-36-3 tiler coiposmoi vinoi* OB OHSTIBRHSD TJSSII 3670 Bilk 3671 Rillc, yhole ZIPOSDE! SOUIB Inaestioa [ 1 1IUTTICIL HETBOD GC SC-IC ICSBJS i Hies »"i OF CUSS 1 1 1.057 a) tnce-S.100 ppa a\| 1. «96 ppa b) 0-< 1 ppa b) Rot airea c) 1-< 2 ppa c) wot giTen it 2-< 3 pp* 1» »ot 9ie« ej > 3 ppa I e\| got giisn Fat t bacl* 1 rat »t basis f 1 I \| f a) 0.01-0.10 ppa a) 0.032 * or - 0.019 b) lot gif«n ppa eitmi i»ro«HTic» a) Total. 1»77-117« b) 27t it saiplaa c) «9.5« of saaples 91 17. « at eaaples ej 6. It of aaaples Besideots of llcUoM IICBIC1II; JDDHS; BlUt; EOHCHl SIPBIHILS; IMIII BIXIBES; I»DOSTBHl IB BIS a) 1972. Ht saaples bl 1973, 123 aaailes c) lot «i«a bl 0.038 » or - 0.025 1 c) 19TI. tit saaFles I dj 0.01-0.1* ppa ft* 1 A) "75. 113 saapl«s \| •) 0.01-0.10 ppm c) O.o»0 * or - 0.026 1 «) 1976, 100 samples \| t) 0.01-0. 2« ppa ppa 1 1 1977, 101 saaples 1 1 t 3S72 \| I a) 1 a] lot applicable 0 Kit «l I I b) 1 b} lot applicable 1 1 1 1 , I i) 0.036 • or - 0.023 I !«»«!« kii?k«st In 1st parity aothers. PP« 1 e\| 0.033 or - 0.017 I 100-141 lactatlag »oaeo. 2 aontks ppa I after dellTery. Residents of Osaka f) 0.039 * or - 0.02 I Prefecture, Japan, varied diets aal ppa 1 CBTlroaaeotal coadltloas. 1 I JIF»: ticiinoi: BLOOD; HII.K: 1 tioiccniiJiiTic»: PISTICIDES; \| FCIICILOHIJITID EIBBHTLS; OS611IC I CBIOBIIE cosponicts \| a) 1»0 ppa (Cat 1 a) 73 ji old aal« rlth coloa caacec BIKBEBCE Sicklier, T.H. Bcilliant, l.B. copaland, fi. tildea, t. 1981 taericaa Journal of Public Bealtb 71(21:132-137 Takasbiji, T. tatanabe, I. Kvvabara, K. Tosblda, s. Korana, K. Ktmita, 1. 1979 International Ircaires of Occupational and EnTlronMntal Health «3:1-1S 1 1 in luone, I. ** basis) I b) <6 rr olJ sale »ith atoaach cancer Ibe, s. b) >. 1 ppa (fat 1 Takaaatsu, I. basis] 1 Japan lokl, ». 1 Rlkl, S. 1 FOIICBLOIIIIIID EIPBEITIS: Oil; Fo1i»sra, K. 1 BmcHtoiocTcioHHiiB: BIOOB PLISSI; 1975 1 HOPtlSIS; J1»I; GasnoinZSTIUL Fnkaoka Hedlcal Joaraal 1 STSTU; PESTICIDES; UIPOSZ TISSOJ; e6(10:610-C1« I tiTra: IIDIIIS; OSEITUI 1 ------- Cocoa 7MO-I2-I I It! 10.11. U 2200 C (approz), BP 2550 C, TP «.5SItO(E-S) atl «t 210 C, 1 u «« at 2664 C. 10 u Hg at 3030 C 1ISS1E 2C73 laic EitosTin IOCTB 11U.TTIC1L BETBCD BOBBER or cuss mei »»i CEIEB1L IIFOlBaTIOB 1 revle of world 11 tent arc OB tke aeeiBBlatiei anl blocoacentratiOB of aaleetei toxic trace aetala IB tuaa laic aid aalli anl otaer aaaialiaa kiir. ««r, aallB, cla»« and boots* tabulated IT qoo^capUe ir«a. iibjccts. svi. a««, exposure fiall«at( a«lTa«s In ppi, and aithorltr Icca over »80 rafcnaces. iftict: tBSfitiia: CHID; craTiu IIIKCl; EOROIB; SIDtlE HStj III iiauiD: soon unica: sonmsi 1SI1; VIITtD nUCBOi; HITtB STHIS; IIII; I1IL3; BITICT; IITIBOII; KSE1IC; E01CI; CIDBTU1; CBI08IOB: cciiit; coppsi; mo; HiBcnsi: IICIEL: SEtziiOB; Til; TIUDIOH; IIB Ectinnoi: mini. POPOL»TIC«S; HOlCCmOHTIOI; BTOIIDIC1TOIS: LUC icitotioi; tcroimot sxvosati; BITES iciinnoi; tnci BIEIIBTS; mils IBIEBEHCS Jankiaa, D.». W79 BS»-600/»-79-0»9. 18» ft- tlOliB it IVI •>«.««, B» -1.2J C, BP S9.T C. TP 1 BB 9g at -60 C, 10 BB tg at -30 C tissoi 3«7* Ereatk - 367S lair SltOSOEE BOVTt iBBBlatlOB lUimcil BRBOD Pill OF CaSSS 1 B1EGI »0-0.01 Bf/CB B - BEaB lot glT«a GiiEttL iircmixoj - lltar aatosotive Pb kaltde aeroaol •iposare. Level* a {auction of {article Bin. Extlaated fro* qraph. lllal Taliae of eboet 900 ca a aad reaplratorT EreqaeacT of 15 CTclec/ala aaiatalaad dnrlag 10-Bia • aipllag tin. ISIJIH: BBOBME; C1LCIDB; CBUBIfB: I HI; lITORami; 11ROSPBHE: tlBIICOUTES 9«fle». 2* leprcseatatln pre-aBalTala treataants are tabilated. IBB (•uibllltT of a holistic, io-aBli policy for aalr imljtls li ntliaed and a«pport«d. iifiEi; Ti»ci Eiinns: HUB: IISTSIIII: BElSnSBeBT IETBOOS; CtTILS: EBOTEIBS; CORPMATITE ivuntiois; itonioi!: IBTIBOBI; IISIBIC; BUIOfl; BBOBIBE; ClOHIIg; ciicuji: CBICEIII: cnoHioi; coaiti: CCPPEI: SIUIQII; GBSHlItDB; SOI.B; ic ens: iso»: niTHimn; L;IC; tetiB9nv«; BICIIL; PBOSPBOBOS; ICTISSIOT; SUBIBinH; 3ELEBIOB; JIIIC01: SHIgg; SOBKId: SlaCHTIOS; sitfBB: TIB: TnaniR; TVISSTEB; tiBt: mceiim KnUfCE p«Baedeie«r< 6.e. VlBchester. J. V. EBtrlroBBeBtal scleace aad Tecbaology 9(101:971-972 Calttleboroegh, C. 1990 Science of the Total EaTlroBBeat 1: 53-75 (Ji Ul (BEIT ------- Eroalne 7726-95-S II lt» 79.904, S3 -7.25 C, BP 59.47 C, TP 1 » 9g at -60 C. 10 M Eg at -30 C IXSSII 3676 Hair ZIPOSOB1 ROOTI tULTTIClt RETBGD 11 1 a us BEE { OF C1SZ5 «) « b) «0 \| I 1 \| B1IGE 1 1 1 a) 0.7-93. 1 ag/o b) 0.3-273.2 ag/g BB»I a) 1.6 «g/g b) 5.0 ng/g •eiians GIIEEJL HFOBB1TI01 i) Coat DO Is B) Saltlple sclerosis patints Sllples ten 7 scalp sites in each tatjfct. C1K1D1; IIIOITS; CEHIBil HEETOIIS STSTF.H oisEisES; a»is: ILOBIIOH: EtOnllt; CIICIUB; CB10BIJTI; CO?PEB: ccic: loom: imsiWBSE; BBTILS: SfLErlVf: SIITKB; SOOIOS; S\JlPffB: finiiun: ri ic ES/BBEBCB Byao, D.I. Bolzbecher^ J. Stuart, I.e. 1978 Clinical cha.lstri 2»(11) : 196-2000 fataM 1C6-97-8 C'-BIO II :».12, BP -138.35 C. SP -0.5 C. TP 2 at. at 18.9 C f IISSUK \| KIPOSV1E 80DTE \| 1I1LTTIC1L \| IOSB5E \| B1I5B 1 I \| SPTHOD \| OF CASES I II 1 II II 1 II 1 3677 \| I CC/BS \|8 I lot detect«d-9.» ug/ir f Ereatl f 1 1 I 1 1 I I 1 1 1 1 1 1 1 1 1 1 1 I 1 ( 1 1 1 1 1 / I III! I GEIJilL MFOBHITICJ 1 1 3.9 ag/hc Ceipent related to notial letabolis. lo other detail! giren Ctrcgenlc saapling technique. Realthr lilltarr and cirlllan eiplorees, D.s. tic Force School of Krospaec Seticiae, ages 23-47 ji. 3 e tot«rs. eilTHES; CBICBIMtTED HTDBCClBBCIS ; CB10SII! OIC11IC COKPOOfDS: CI10BOB!»EIIS: FL3CBISE COKPOIHUS; JBtlTB; EICCBOLS; TEI1S; 1C01TS BEIESZBCE cenkle, J.P. Ca.p, B.j. Velch. B.E. 1975 IrchiTes of FDTironrectal Health 30(21:290-295 alcohol (8 ct) l f9 CI) 71-36-3 C«-»io-O 81 7«. 12. SP 117.5 C. TP 5 •• Bo. at 20 C 1 IISSM 1 1 1 3678 Breath zirosoBi soaiz 1 t IUTTJCJI HETHCO oc/as insta or cisss a tues lot oetected-35.0 ag/hr (»n mil '.1 ««/hr HUl) GfHMI IIFOIUTIOI ccifotad related to aortal Mtabollsi. lo other details give* Cryogenic itmllmq t«ctniga«. Baalthr ailitary and ciTilian etployaes, D.s. lir Force School of Ictospace e, aoes 23-7 yr. 3 linkers. tilings; CltOIIIHID BTD8CC1SBCSS; cncim OBSHIC CORPOVIBS; cncBOBiiznts; r»ctt» COIPOBIBS: fiiiti; iicctoLS; tuts; icntts EBFEBEBCE Coakle, J.P. Caap B.J. Reich, B.t. 1975 Icchives of CnrlroaaeDtai Health 30 (2>: 20-295 ------- Iitrl alcokel (8 CD 1-8«taaol (9 CI) 71-36-3 ca-no-o II 71.12, BP 117.5 C. TP 5 » I« at 20 C (COETII3ED) TISSUE 3C79 Breatk EiMsrai tovn iBiiTticit 8ETBOD SC-HS •mast or cisss 5 (387 saaples) S1ME lot gira 1.» ng/1 Geoaetric GZBZMI ifrosaiTioE Beamed at 25 C aad 7(0 aa Bg 36.2* occurrence lover aad upper one-sigaa Halts 0. 1 and «. 8 nq/1 flea-lthy, 18-35 yr old, nonsaoking. at tan blacks aad caacasiaas. Chicago, 11. Bigldly controlled experiaental conditions. EBIHB; 1 ICC SOLS; I1LIMIS; 1DU11S! CB10BII1TZ1 BIDBOC1BB01S: lOllTILB CIGIITC coipcmis: RZILTB B»?IBDS: 1IB1111ICI; BE11E01ISB; BITIEOLITIS; ICJH11TIOI 1IPOS8BE; UBB1I 1BE1S lErEBESCf Krotosz]nski, B.I. Braaean, G.8. O'leill, H.J. 1979 Jonraal of Jnalytical Toxicology 3:225-23 Cidaiaa ca Itl 112. M. 8? 321 C, BP 765 C, TP 1 aa Bq at 39» C. 10 •• Bg at «86 1ISSV! 3680 lerta 3681 Blood EIPOSOBE BOOTE Inhalation iiiimcu. nTTBOD •1 115 IDHBSB or cisss 3 I1IGE Bone detected 0.7-3.8 ng/1 BEII lone detected 1.5 og/1 6EIIB1I. IBrOSBlTIOl Bales Pcoa a groap oC 61 autopsies. fetensic aedical •xaaiaations, Japan. Bales, aeaa age «0. « yr. resales. •eaa age 37.4 yr. TBICE ILEBEITS; IBTOfSIBS: J1P1B; •mains; IBSCTIC: CISBTOR; COBILT; CBBOnnB: CCfPIB; IBOI; HIICOEI: iigiDB: BieiisivR; BIBCMZSB; HtlDHJl; 1IIIBOII; SClIOinB; StlEIIIB; TI11IID!!: T1B1DIOB; ZIK; ECLO: BBOBIIt; LIVES; KIDIETS: CIBIBBDB; CIBEBE1LOB; HS»BT; BDSCLES; EIICBEIS; SE1BEI; LOIGS; 1OBT1; ICT1LS: COBP1B1TITE ET1L01TIOVS; SIX; rCBHSIC HECICIIZ 12 saaples Direct detettiaatioa and extraction ctocednes agree. Iclders, garage personnel aad patty •crkers in Svedish airplane factory. . I1DOST«I11 PCLLnTIOI; COBPlBlTIfE iTiioinois; ciDBiDB; SVEDZI; icms; EIOCD; US HI; BI01CC050L1TIOB BZrEBERCE Tnkava, a. Svzaki-Tasnaoto, B. laano, K. Terai, B. 1950 IrchiTes of ZnTironaental Bealta 35(1) : 3(-a Lagesson, T. Indrasko, I. 1979 Clinical cheaistry 25(11) : 1948-1953 («EII P1GE) ------- Cadalta Cd »t» 112. ««. It 331 c. SP 7SS C, TP t • »J 1 I aaaa for a»d anflraaaantal afraeta of 1 Tolpa. s. 1 1 Cd, as rapactad tr tM lataraatlaaal 1 1979 < I laat tine Orqaoiratlon. I Cadalaa Basaarct Diqas 1 1 1 lo. 1, 24 J>P. I j I smn: CUB ma: anus; iMsoBmn i f 1 1 SttJOBSj II fITO llHTSISi BtOOD; ( r 1 I OBIII! EIDItl BISHSJS; SOIB 1 I i I cisusts; cccorartoiii Distisxs; i i i I fcmiixoi inosiTBE: IIOITSTIUI. t 1 1 I fCUOItOI \| 1 1 1 1 III t 1 J«» I Iijaatlot \| a) M 1 a) lot atiata a? 0. IS >g/IOO al 1 al JOT* Itrlag < t It* from aaaltar \| Bucks* , 3.r. Mood \| laialatloa b} 20 1 b) lot gli«a b\| 0. IS aj/'OO §1 I b\| elcl* liilas < 1 ka team aaelte? 1 Boala, a. t \| 1 1 1 f f 1 1 1 1 1 I 3695 alaod 3««C Hoot ^ c) »0 t c) lot glaa c) 4.11 og/100 tl I c) Cklldraa at 2.5 ka froa aaaltar 1 laiaar^a, 1. d) 19 \| d\| »ot jiraa 4) 4.1 ag/100 al I d\| sroaa bof \| traaax, p. at 1 \| al art ftr«a a) O.W ag/100 al 1 a\| Irbaa airla t cla«Ts-Thgc«»o, r. 1 1 1 1 * » \ i) «J If) lot fla« a) 70 b) «0 a) 0.02-t. »5 »9/10J al ft) 0.05-9.SS ag/100 al .3-29.0 «g/l \ f> 0.08 at/100 al \| n laral ekildraa \| lafoatalaa, L. aaitlaaB 1 latiaatai fcoa qrapk \| Terdafa, 6. f \| 1980 f seiool-age ekildrao Urlng tear Pb I CBTfcoaaeatal Ba«ir-6 I caaltar in 8«lgi». Controls froa I 22:95-108 1 oral aaO trtau araaa. \| 1 « t uieatiss: c»m«: ustnc; issraic i \| Ciffinc CO»PCB>BS.- CBUBBIl; \| J IBttSIlUt IIBOSPHHIS; StttllXS; \| I IITltS; ILDCC: OEHJ; BZLGNB: 1 I »c;niTioi inosBti; mil iai»s: f I oBfii tins i i i I i at 4.12 « or - C.01 \| a} ceatroli \| lawarrs. s. ag/100 al \| t\| tasljaet of foil (tad arag I Joels, a. BJ 0.1« * or - O.«1 \| \| taraard. i. •7/109 al \| Icaaa, aaaa ag« 82.3 rr, fr»a I laekat, J.P. (S.I. 1 \| C4-«ollata4 ataa Kiaqe) , aad 1 1989 1 central, aaaa aaa «1.1 rt. froa t Iota national IrcalTea I Ctaclarol. lalglaa. I of Oocapatloaal aad 1 t tMicoaaaatal Raaltk I 1100B; BIOOO niSU: UHIIS: ClBariS; I 15:2T1-2T r tilt: XNCD31] 1IK; ICIilS; SBtGIOB; ( t isi; porvtuioi nrosvu; mismu i I fcLtirios; stntns: MDIEI nsiisss i i i lot 9la» \| cccaaatloaallT alpotad (-39 IT- lo 1 lblgi«o. I. I ctkat 4at«ll( ql»a. \| «attaa«a, S. t 1 W»t 1 33-»» TC olta. Sta&aa 1 fhialca la BadiciM a»l 1 1 Jlolaji J6(1):1?-2S \ »tnt«: Bioct: xinnsi ntint n t l IIIQ i»VTJtsi tBismiatn >nao»s; I I cxiramt occOTVtiotn wtmj: sniis \ I \ Ul CO ------- Cadaiaa 7«ao-l-e et lt« 1t2. «0, BP 321 C. B? 76S C. V? 1 H Bfl at 39 C, 10 u Rg It »8S (COBTXBIED) IXSSBt 3C87 Blood. plasia 3688 Blood. sens 3689 Blood. aan* BHOSVSE Bone Inkalatloa ABAlRICAl BBTBOD US US iBBBSB or CASES •) 60 b» »5 e) 70 a) 260 b\| 260 EAESS a) O.OS-O.S5 ag/100 al b) 0.01-0.28 ng/100 Bl c) 0.02-0. IS ag/100 el a) lot 9i»e» b) Bet «i»«n (BER ISAB a) 0.13 B9/100 Bl b} O.Oa B9/100 Bl e) 0.10 ag/100 Bl Geonetrlc a) 16.* « or - 6.3 ag/1 b) 1.2 * or - 1.1 a 4/1- PAGE) CIlMAt IEFORHATIOI at Iesid««t» of Liege (aoit collated area) t) Besideats of Brussels (less foliated aceal ct tesileata of Charlerol (eentrol atea) lleea residents differed fros Charlerol (p<0.01) aad froi Braisels ------- CatllU Cd ttl 111.10, BP 321 C. BP 7«5 C, TP 1 a* Hg at 39* C. 10 n 19 at «86 fcomiota) f IISSII BOW 3691 Brail xtroscm IOBTB Bair 1 1 693 ale aiiimcti us it - - it i i 'vasts or ctsi i 1 US a\| 31 b] 22 1 1 1 f 1 t tuet t3 tot ippiictblt b) tot applicable c) lot applicable 1) lot applicable a) (one detected b} low detected c) lone detected d) lone detected •iii i Gimti nnnmo* ismsacs l i if 8.3 fs* l tt Spiae, aeanred tr US Slaiier. J-»- b} 2fi * or - 13 ppe I tl Spiae* aeasured y It ldiaar B.C. c) 3.2 ppa \| c\| lib, aeatored by US Bce«er, 9.9. 11 2.1 ppa \| 4] renr. leanred IT US Barrey, T.C. 1 180 I Ktopaf ipeia»a». Bittetrj plate Illtiai Joina.1 of 1 aaker, aorted iltk Cd foe 3« 1C. Icdsttrial Seilcioe 1 37.-278-2M I fOIR; KIC1ZTS; IITIB: IBTCISIJS; l ciDni; aniLs; occratiiottt I BmtDS; OIIIJD niGDOR; OCCOPHIOIll l [isiisis; aim i 1 1 a\| noae detected I a] Riles, cerebtaa, t nblectE I Tifcaia, B. b( loae detected \| t) Feialas, cerebn. • nbjects t SnaU-Tansota. B. c\| gone detected I cl Bales, eecebellw, ( nkjects I taaao, K. d) loae detected I 41 leeales, cerebellns, 4 lafcjecta 1 Tetai, 1. 1 \| 1380 I tioi a gtoaf of Cl aatopcles. I Icehires of 1 (oceulc eedicel exasiaatlOM, Japaa. \| laflrowental Vealtb I Bal«, eeu a«e tO.S rt. leaales, I 35(1) : 36-«( 1 ieaa aae 37.1 rr. I 1 1 1 tsict ttEtitrs: iiropsrss: JIFH.- i i juranui1; nstxtct ctasnas cososi i i CVlCBIQf; CC£PEB; IBOlI 91KCCBI; F 1 iriru; nieitsite; nisiaist: i j meiom; iiiifloiT; scamof: 4 I SfLIBItl; TtlltHTK; MltDIta; ZIK; I 1 «CIt: BOTBIf!: IiriB; BIDUIS; \| 1 cntnm; ciBSEiittia; BUST; BOSCIES; i l Tjirnis; srrinr; IIBSE; taiti i I BITIL3; COaPlBtlirg irilOlTlOIS; SIX; I I tctiisic gieicm i 1 lot qirti a) 1.72 pp« a) tea.nli« JisafcUd \| P16I, F.O. lot gireg b) 1.08 ppa t) Controls t Parlies, '1. I 1»T7 l«ani>4 disabled tad norsal 3rd and I Selene atb grade stideats i* Caaada. I 19S(«3I3) t2M-2O« I CIICI01; RteilSIII; POI1SSID; \| l i scriM; ciEHina; costif; cotnsi: i I ItOl: HID; MIGaltSt; ZI1C; I I ctROKina: ixtflMit amcnst: anus; t t 1(11; CSIXJBfl: Clltlt \| 1 1 1 t J leTiev 21 repcesentatiTe \| CBittleboroff^h^ <• 1 pce-aaal?sis tr«ata»nta are \| 19S9 1 tatalated. Tie Ceaslbilltf tl a j science of the Total 1 kcllstie, BO-nsb pollcr fot kaic I Emlconaeit »:53>75 1 laalysls i» ovtliied and supported. 1 t tiiin; TBtct titmns; snt: I 1 IUSTSH.H; BftSffiraiBT BITEOCS; \| l itiusi tRcitits; ccatuitin t l mumais: UOBUCB; tinscn: i I llSItK; BlllOa; BBOBtM; C1CJIOB; f I ciicns; ciLCiiiz: caiosina; conn; i l ccppti: siiuoi); BitBuinB; coit: i 1 ICDIll: MCI; LimiJUB; lilt: \| i iiensnn; Biiemsi; BSBCDM; i I ECITBDI11H; IICK1I.; PSOSPHCBnS; t l tcussiii; minim ; SILIIIOB: i I E11ICOI; SILTES: SOIIUB; SIlCITlnB; 1 1 SVITm: Til; TITtlllfl; T01GSTII; I I 1I1C; IHCOHD1 \| 1 1 (IE1T FUSE) ------- Cadlloa 7«fl-«3- Cd »ti 112. M. BP 321 C. BP 76S C, VP 1 si Eg at 39* C. 10 » 19 at 8t (COITIItlED) ixsstz 369 Hair ,„, Bale 3«« Balr 397 Beart EEPOSVR BOJTB 1IILTTICU \| IDBBSB •EMOB »CT n ii OF USES 1 a) » b) 7 0 11 4) TO e) 10 a) 10 i) » UMZ 0.66-3. ea 19/9 a) lot given b) lot glten c) lot gl! CIEIT P»GZ( ------- CaJalta 7«ao-«-9 Itl 112.10. IF 321 C. SP 765 C, TF 1 »a Bo at 39» c, 10 aa Ra. at MC (COItKOEB) TISS3I 3698 XUaT 3699 THaar ( I 1 t 3 no ii4ar mason ton i i aBumcu BATBtJA US M US 1 1 nriMti i met OF C1SSS \| 1 1 a) lot tint 1 ii lot «irw 1 c) Bot giro 1 A) lot glm 1 •) 5S1-1B9I pp. 1 t) 833-939 pp. I g\| 200D-4000 ppa I t) 1230-2850 ppa I lit «t 1 1 1 1 1 1 t i t I - - 1 •) 19 11 5.6-110 ag/9 (wt «( b) 3 \| b] 5«-«T aa/g (Mt at) 1 1 1 J 1 1 1 1 1 1 1 4 1 1 1 1 1 1 1 I $ J a> 1.67-13.1 ag/» J \| b] 2.3V-37.2 «J/T 12 \| CJ 0.503-27.6 aj/j 1 let rt 1 1 I 1 t 1 1 1 1 1 1 1 I r t i BUI i eiieiu monunoB i nnmcs i i i i t i a) 3231 ppi ( (I 17 caaear patiaats \| Baaacc, O.I. b) 20«1 pp> \| t\| 58 BOS-C«DC«C p»ti«at« \| caloccl, l.Y. c\| 1188 ppi \| c\| 1ft Kttaiotecs (a«nr a«at«a) I lasaalUjia, T. it »« ppa \| a) 5 laokara, 1.5 packs/oar 1 Illllaaa. Jt.I. •) 1221 ppi \| ) 2 »al»s, «9«a 10-11 71 1 Ftakaclon. C. t) »fl1 ppi \| f\| j «» 2197 pp« 1 M • (aaal«a. a««a 50-59 re 1 S.JiclB 1S(12) :95«-9«3 ask »t \| \| I Ktcpatva ftaa hospitals la forth ud I 1 feath Carolina. Marts and I 1 caecaatui. Halt, qM 16-91 »r. I 1 Calldiaa, «i«a I ala I Tnkaa, B. («t it) ) t) Taaalaa I SaziU-Taavaota, B. >\| «0 + or - 6.7 ag/q 1 1 taano, K. ;«st «t) \| ma a 7roof of 61 avtopalas, I T«ra.i, E. ( tcxa»ic mtitctl enainatioas, Japan. I 1980 1 >ala, aaan aaa 40. 6 rr. f«aalaa< I Jrctl»e» of 1 aaaa aq« 37.1 TT. I EaTiroaMatal B«alth 1 1 35(t\|:3C-« I nice KS8ZIH: tmotsisss JJP»I; t 1 iKmim: tissue: cjnaiirs; COBW.I: i l cnomas: const; icot; BEBCMT; i 1 iititrB: BiGitsios: iineuisi: i 1 IBSICIOH: IITIBCIT; SC»»DI05; 1 1 sitnimt tiiiiios; TjHBiijjt UK: i l eciB: Bfanic ixrn: KISMTS; i i cisiMia: CIIEBIUOI: n»»; HOSCIBS; i l incBiis; svixn; niesi tcni: i ( tttltSs COSFIMTln UTU.D1TIOKS; SIX; I r roiifsic RICKIK i i t i r a) 2.< o oroof II. 1 t Ceatrol, aon «3-72 yr. «ao llwd SO 1 1 la fraa tb factorr- Sawdai. I 1 1 l siiDEf: CIHTISS; tnttrsi LITEI; i 1 It IBS; CODUmlTK IIStOlTIOIS; I i iicvsniii Bieizis: nisaiiBin i 1 KTBOB5: JITIBOrr; IBS MIC: CWIXVB; I l cismi: c BIO ting; CCMIT: coteii; t 1 eets; I8O«; IIITUIDB: L»D: ( I iJieiBisi; BISCUIT: BDITBEIIDR: i \| EMSFROtOS; SBBIDID1: SCllIIOB; \| 1 MI Hi-ii; sum; TI>: raiesnf: i l me: win niuas; notismti i 1 fiirrs; sBtneis; TEWIIIHB i i . : i (ini notj o> ro ------- Cadslui 7UO-B3-9 ca 111 112.40. IP 321 C, B? 765 C. TP 1 aa Bg at 3M C. 10 •• Hg at «86 fCOITIinBD) TISSUE 3701 lidaer 3702 XidBay 3703 Kidney 370* Kidney IXMSOn BOBTI Inoestion 1IUTTICU aZTIOD US 11 I* IUHBEB or cisss 1 a\| 19 b) 7 cl 11 d) 10 •1 10 BUGS a) let applicable b) lot applicable a) lot given b) lot given c) lot given d) lot given •) (Ot given III) a) 77 ppa b) SO » or - 20 ppt a) 0.07 * or - 0.06 ft* b) 13.33 » or - 22.72 PP> o) 8.57 * or - 3.97 ppa d) 2. 10 » or - ia.10 ppa e) 20.89 « or - 12.26 ppm let t GEimi iirosBitioi a) Measured IT IIS t) Beasured by It latopsy speciaeBS. Batter? plate •alter, vorted «ith C4 for 3« Tt. Cateoaalacia. reaal tabular disfaictioi tens; KIDII1S; LIT IB: ITCCESXIS; citBMB; BitiLS; occo?iTto»li BIHBDS: uinsD nisDOH; ocajpinosiL ciszisis; mm a) Ibortases b) »9«a 2-5 ir c) Iges 13-11 rr d) Iges 25-3* TC <) loe* 65* jr late also aivea br race a«d occupation. Igtopaiea of accitental deatlis in Ckio, ages. <1 ao-qteatec thao 65 ji. aid abortuses. mils: OOBIDI: HUE; KIDIIIS; iitn; ttttofsns; smnis: icstccos; 1«I; FOPOUTIOI BIPOSBBB: 1BDITS; itotEscsns; CHiiDBii; runs; OHIO t« ------- Ct »t» 112.10. tt 321 C. >P 7S C. T 1 » B? at 39» C, 10 n H? tt 186 IISSVX \| JIPOS1JBB ROOM <»JITTIC»I inaljn \| )»GX I BBTBOO or CJSSS \| 3795 KUMT 3106 Xidoer 3T07 Kldn.T 3708 ii fear f Inialatlot 1 1 1 1 m May SpctroMtcT » it i3 b) 10 s »0t «iT«» 0957 ig c.»-ii.8 ag 13 4C* ttolcal tt acute \| I (caiaoDitif. 1 1 1 I BHIH nieici: IIDHTS: ijfis: i I lines; trtiH: stii-j BJUBDJ; IRU. i I rciscwirs; HDVSIIIII itaostmis: i f HRiiiTiei: cocnp»Tiofu nzuas; i I cicaMi; SIT t is: inropsirs i l i a) I5.J * or - 2.) a? a) forkari, cd ptocaosinq plant < fllla, I.J. i) 3.7 * or - 2.9 19 t) Cottrola \| Bocqu. l.D. Woaatcie \| zanzt, I. Baag* at critical l»rla for I Tasaaara^ S. Ca-ldocc4 titular »cat«iaarta 1 Tarts;, 9. •atlaatad at 150-304 tg/1. \| Cot, 5.B. 1 181 ItntTS; IIDin DISMS3S; noOTS; 1 Jooraal of Toilcoio^r tlfSB; IT 1TTO 1IU.TSIS; cigilDB; I ««J InrircBaBntil (KUST OCCOPJtTIOIU H1318DS 1 Malth 7:491-703 1 lot glT« Talves foe cort«i. Occupitiooallr I Jltlgrai, 1. eiTOMi S-30 ic. (a atkcc details 1 Battssoa, S. 9i»ai. \| 1981 I Pifalcs li S«4iciM tal 33-M TT oUj, Sndn \| Biolofly 26(1):1«-2« 1 j coirs ; BICCC; ITIDIITS: mm: Tt i fltO UaLTSIS: BMSOEERIt BIT HOBS; I CIEtlOR; OCCOfHXOBU. BlUBDSi BTTiLS I 1 («trt MGE) ------- CadliBI 7»4»-43-9 ca lt« 112.40. IP 321 C. BP 765 C. TP 1 •• Bg it 394 C, 10 n Bg it 86 (COITIIDBD) 1ISSDI 3709 ll»« 3710 liMT 3711 liver 3712 Liter EUOSDU MOTE ^___^_^^__ 1IUTTIC1L •ETBOB US 11 US us It ITHBES Of CUES a) 8 b) 6 a) 8 b\| 9 c) 11 1 MICE a) lot givea b) lot given c) 52-281 pp« 4) 75-605 ppi laa vt 0.66-11 ag/g (vet «t) b) 2.4-1S ag/g (vet vt) a) 0.071-1.16 eg/g; b) 0.080-3.21 ag/g e) 0.0010-4.8 ug/g Vet vt a) lot applicable b) lot applicable •111 a) 2«8 ppa b) 24 ppi c\ 143 ppi d) 287 ppi ish vt a) 4.2 » or - 3.5 »g/g («et vt) b» 8.9 or - «.5 aq/g (vet vt) a) 0.32 og/g b) 0.96 ag/g c) 0.72 ag/j Vet vt Bedims a) 172 ppa b) 210 * or - t ppa GEIEI11 mOIUTIOl i) 17 eaacer patleats t) 58 BOB-ciBcer patieat* c) 10 BOB— Backers (never snoked) a) 11 siokars c) aid d) 40-70 yr old aal«s. •atopsies fro hospitals la lorta and Soith Careltia. Blacks aid Caacaaiaas. Adults, ages 16-91 yr. CitUraa, tgas 1 days-t jr. i IT its; softs: inEi; HOISTS: « CHITS; C1IIOBB1; CIDBI0B; II»C: HID; 10 wi cuouii: SOOT a CMOLIII; inopsm: HOICCTIOI.ITIOI: IICIIL siniiES; net: swntxsi TOBICCOSJ SEX; IIOPII3BS I) 1«1«S t) Teaales Iioa a groap of (1 aatopsiea. forensic aedical exaaiaatlons. Japan. Bales, lean aga 40.6 yr. Teiales, a«an a^e 37.4 yr. 111CC tlEBIBTS: IBTOPSIES; JlPlI; unBiHB: iisnic: CUBIOB; COBUT; cisoiiina: ctiPiB; i»n: Biicrat; IIOIOS; S1GIISIOB; ailCllESE: SIIEIII: timiodl TIUDIIB; tnc; CCIDt BBOBIII: LirEB; UDBIIS: ClBEBtIB; CtEFBIIlUB: BHBl; BOSCIES; IIICIE1S; SPIIB1; LOassj 10111; B1T»S; COBFIBlTin ET1ID1TIOIS; SE1; ICBIISIC ISOICIIZ a) controls B) locker grogp I c) florker grcap II Caceascd reflaecy and snelter •orkers aqes 55-76 yr, exposed to btiTf ntals 1-3 decades. Tlae tetveen retireaeot and death 0-1.5 yr ill IJIDIS I and 2-19 yc, groip 11. ccntrola. aqes 43-72 yr, vho lived 50 ki froa tbe factory. Svedes. Slttll; Cltims; ItHlITS; liyiB; IOISS; COBP1S1TITI E11L01TTOIS: IECOST8I1I BISIEK: RISOBEBIIT B1TBODS; lITIBOXy,; 1BSBIIC; ClDBIOa; CISIOB; CBBOBIUn; COBlLTi COIPEI; GCIDi IHO»: llTTBllOa; LEAD; BIBG1MIS1: ntBCTJBI; BO1TBDEI03; IEOSPTO80S: BOBIDinfl; SCIIDIOB: 51IEID1; SIIVES; TIB; TOIG5TEI; IIIC: BIllTt B1ZIBOS; IVDOSTBIIL FIltTS; sniIEBS; TIIIOBIOB a) ae&sared cy IAS t) ••asnred IT la Intopsy speclieos. Battery plate Baker, vorked vith ca for 36 yr. BOIES; KIBItIS; J.ITIB: IUTOPSTES; C1C8IOH; H1IIS: OCC5PITIOIH1 EIHBDS; 3-IHtD KIIGDOB; OCCOPtTIOVU tlSItStS; OB HE EZRtSICI Baaier. D.I. Calocci. 1.7. BasselblaA. T. (illlaas, I.E. Piakerson^ c. 1973 Joarnal of Occapational Hedicine 15(12) : 954-563 Takava, B. Sazakl-yasaaoto. I. laano. (. Terai, B. 1980 IrchiTes of iBvironaeatal Health 35(11:36-44 Brone« D. fordberg. 6. tester, P.O. 1980 science of the Total Environment 16:13-35 Blainey, J. D. IdUS, 5.0. Braver. O.S. Harvey, T.c. 1930 British Joan a 1 at Industrial Beflicine 37:278-284 (HIT P»5S) ------- Cidaioa 7MO-»3-9 Cd It 112.10, » 321 C, Bf 7«S C, W 1 » Be at 39* C, 10 » Hj at «8« (CORIITOD) IXSSBI i nvosm nati i amnxcii i i i stmat i i i i i i t 3713 \| liver 1 1 1 1 1 U 1 1 t 1 1 1 1 1 1 1 f 1 1 1 1 1 IIUZBI \| OF CASXS \| 1- 1 •1 19 I a) c\| 11 d) 10 «> 10 1 >) c) V e) 1 1 HMS \| 1 1 1 lot girts \| a) 0.01 lot alirea \| ft) 0.33 tot gl»e» ppa lot alien lot alien O 0.97 ppa d\| 1.25 ppa e) 1.97 PP* let »t 9B1I ppa « or - 0.35 * or - 0.«9 » or - 0,75 * or - 1.08 l ' crntai irroiiunoa l i i 1 a) Jbottnes I 61 soe> 2-5 rr I c) aoea 13-K fr \| d) iges 25-31 rr 1 e> Joes «5* jr 1 Cata also qtrea tr "c« «J I ccctpation. 1 1 iBtopaiea of accidental deaths la I Cbio, a«aa, ber 7, 1975 I I I I I I I I l I I 1 1 1 1 1 1 1 1 t 1 1 1 1 1 1 37T« Imqatiom \| I Unr t 1 1 1 1 1 1 1 ! i i i i i i i t i i i i aed abort**. tints; ctDinii mil: EIBHTS; XXTIB; IBTOPSISS: s»oiw; ICBJCCOSJ jes: fo?njinw rwosraij mans; ttoiiscnrst antnttn rms? ono enl«r. Profil* of taaltbr «nb]»ct«. (as«ll»* dati for d«t«r»i»ins ekaiigM IB ntrltiaMl atatas Iroa ItdostrUl 1 t 1 1 t ( 1 1 Sttart, B. J. f Rott«son, s.r. 1 1»7« 37T« lagesuos III 1 Cerle. Profile of kaaltar nb]»c tirer III 1 (asallaa data for deteralalae ekaa 1 III I ia n«triti«al statas fro a Itdoatr III 1 feed prooessioa tecnniaies. 1 ' 1 II l tit Hunt; 1D01TS; riTVS; 1IT1IT l l l BIOCII siBim: ui«; KID»TS: inn; 1 1 1 em; imn: mits; FOODS: SOILS; III l TiejT»Tlo»: ciBsira: coirxts 1(1 I lUSHXSt: B1T11S; TMCI SUBSflSi III 1 tlK 1 1 1 , « » 1 1 3715 1 Inkalatloa 1 1 lot jlren «.« ao/9 »•« «t I 34 sin eipoeere liter 1 1 1 litopsr tisaae 1 1 1 II 1 I 3« r old selder 111 II III 1 Visnaea, persisteat non-prodoctire III 1 tcogb. Ill 1 1 f 1 i«atk 5 d«7» after exposare. laxj III 1 flowed ckaDocs typical of acvte 1 III pteaaoaiti<. 1 III 1 1 1 1 1 1 1 l i 1 1 f 716 I 111 1 a) 83 ier 1 1 M 10 i DIITII Kiiecci: Kioms: IITIB; a) 0.8-120 ppa a) 22. * or - 3.3 fc) 0.6-7.9 fpa ppa b) 2.6 * or - 2.2 ppa Seoaetric t 1 INGS; a tilt; HE4LT8 giZlSIS; ami rciSOITIG; HOOSTBUI MVOSFHSISS; IH111TICI; CCCVFITIOfU B1JJSB5; cicanu; urtJU: »oio?siis a) lorkers, Cd proeessiaa plait t) Control* aa«e of critical levels far <4-iaace4 titmlar protelaaria eatlaated at 150-300 »o/1- ICBITS: (ItllT DJSEISBS: KIIIITS: IITEt: II TITO IfUISIS; CIDBlnS; ifTils: occopiiioiii iiziios t«. i eatarie, B.I. ges 1 Kofelason, s.r. ial I 1»7« 1 »e« Kalaad aedical 1 Joonal (7(<03l:3-B s: i l l l 1 i 1 tacas, P.I. 1 Jarivalla, J.G. 1 Jones, J.B. 1 S009B, J. 1 Tale, P.t. 1 1930 1 laacet 2(8187) :205 I 1 1 1 1 1 I 1 1 1 1 1 Fills, K.J. 1 Borqso. (.0. 1 Zaaxl, I. ! Tasaaara, S. I fartskr, B. 1 Coba, S.B. 1 1981 1 Journal of Tozicologr 1 aid ItTlronaestal 1 Bealti 7:491-703 1 (•ire PISE) ------- Cldsill 7MO-43-9 cd Itt 112. tO, IF 321 C, BP 765 C. T? 1 la Bg tt 39« C. 10 II «g at >86 (COmilXD) IISSSB 3717 Lang 3718 Ling 3719 Ing 3720 Bilk BIMSOBB BOOTB Inhalation IngestioB 1BUTHCU BEIBOD Bl US BOBBBB or cisBS a) 3 b) 2 a) 8 b) 9 O 11 1 SHOE a) lot givei b) Bone detected a) 0.001-0.17 ag/g b) 0.058-0.78 ag/g c) 0.046-1.4 »g/g •at lit Bot given BB1B a) 0.90 « or - 0.85 «g/g (vet »t) b) Bone detected a) 0.026 ng/g b) 0.42 ag/g c) 0.11 og/g vet vt gedians 4.7 ag/g net vt GEBIBAL IIFOBBATIOI a) Baits 11 resales Iroi a groip of C1 aatopsies. forensic nedical ezaalaatiois, Japan. Bales, sean age 40.6 yr. resales. staa aoe 37.4 yr. IlaCB E1BBSI1S; aOTOPSIBS; JAPAI; llEBIItia; ASSEBIC; C1DBIBB; COBALT; ctBCBTOs: CCIPEJ: IBOI: BEBCOTI: IIEITJ1; BAGI1SIBB; BAIGAIESE: BVEIDTVB; AITIBOBT: SCaBDZOH; SHSIII4; TI11BIBH: TAIADIOB; ZIBC; COLE; BSOBIII: UTEB: HBBETS; CEBEBSIBj; CEIEBELLOB; BB1IT; BOSC1BS; SIBCBE1S; SHBEI; LOBGS; »CM»; aillLS; COaPllaTITB IT1LH1TIOIS ; SET; ICBEBSIC HIDICIIE at Control* t) worker groap I c) lorker grcap II leceascd raflasry and sneltery •orkers, ages 55-76 yr, ezpoaed to heavy aetals 1-3 decades. Tise btveea retlreneat and death 0-1.5 yr in groap I aid 2-19 yr, group II. Ccntrols, ages 43-72 yr, ho lived SO • fron tke factory. Svede. SIIDBB; CaGaTEIS; EIDBBIS; trTEB; HUGS; COBPIB1TITE ETalUTIOBS; tlCOSTBIlL B1SIEBE; aElSOEEBIWT BIT BODS; IITIBDHT; IES1IIC; UDBIOI: CISIOB: C1BOBIOB; COBllI; COFPIJ; GOLD; HOB; IHTBIBOB; IBID; UBGIBBSI; BIBCnil; BOITSDEIUB: IBOSPHOBU3; BOBIDIOB; SCJBDIOB; SILZBlnl; SI1VEB; TIB; TOBGSTEI; II!C: BEILTB H1ZJBDS; IBDOSTEI1L ElaBTS; SBEITBHS; TBLL01IOB 30 aia eiposvre litopsy saipla 3« yr old aelder Cyspnea, persistent Bos-prodactive ccagk Deatk 5 days after exposure. Long ctoied chaages typical of acute pteasoaitii. OIITED KHGDCH: nOBBIS; 1HIE: IHIGS: nan i: HEIITB UZAXOS; IETIL tCISOIIBS; IICaSTBIlt UHOSPBEBES; IIBIUTIOI; CCCOPiTIOBU. BJZIBOS; ClCBIlfl: BR1IS levle. frofile of healthy nbj«ets. Baseline data for determining changes fcod processing techniques. Ill :EILa»; 1DBLIS: EETUS; II'llTS; ttooi SEIDB: BUB: KIBIETS; urn; IIIK; B5TIH; DIETS; POODS: SOILS; 1EGFT1TIOI; CABBIOfl; COPPEB; BalGalBSC: BET1LS; TB1C5 EIEBESIS; me IBTBBEBCB lakan, B. Sazaki-Tamsoto, 1. Asano, I. Teral. B. 1980 Archives of Eavironneatal Health 3S(1\|:36-44 Brnne, D. Bordberg, G. tester. P.O. 1980 Science of the Total EBTironnent 16:13-35 Laeas, p. A. Jarivalla. 1.6. Jones, J.B. Goagh, J. Tale. P.T. 1980 Lancet 2(8187) :20S Gathrie. B. B. Eobinsoa, a.T. 1978 lev Zealand aedical Journal 87(603) :3-8 (BEIT PASE) ------- ctfliiu ca »1» 112.10, BP 321 C. If 7«5 C. TP t mi Bg at 3»« c. 10 u 89 at «B6 IISSU BXFOSDKI BOOTS 1IU.TTXCU. 1 ITBBSSB JI1BI IBal ( GJI1SU. UTOtBITIOl i RlriSElfCI HEIECD \| Of CASES I I 1 • 1 3T21 U a) C c) tone 4et«et«4 Basel b> « t) lot glT« 1 1 1 t 1 1 f 1 ( 1 1 1 1 1 t 3722 in a) C P«ncna« 1 J» 2 1 1 1 1 1 1 1 1 1 I 1 1 1 1 III 1 i r i i i i 3723 srltn S7J* otlo« » nhalatioa , » n us \ \ a) 9 i b) * t a) lot «i»«i> b) Sot giren ) Jot jif«» 1 Cot gives 5-1.2 »g/l l 1 1 a) lone detected \| •) 'fit' I Inlwn. S. b) 9. 1* » or - 0.27 l t> Feiales I Suafcl-faauoto, •. ag/q (»t «t\| \| t IMOO. K. 1 tram a ?roup of 1 xtopsiva, I Tetal, R. 1 \| (oceanic cedical muloatlott. Japan, l 19BO ( \| Bales, •«• ao« 40. t re. Feiales, ( Irchirca of 1 i«a> «9« 37.* rr, \| tmironaettal E«lth I \| 35\|1)t36-«H t IBICI tiEniis: ioio?siBSi ji»>; i J 1108I>9«: »5E>IC; CIOBIOB; COBU1; 1 t ceieini; cemi; ttn»; BIECDRT; i 1 noiDg; fnoiisiDB: «aetiEsi: i \| BOSIDI39; 1HIBOJT: SC1IDII1; I i fnttii^; TIUH09: Tinnioa; nice; j l GCIB: itonit; IITEJ: noicrsj i l CHIBBOS: ciEnmnt; n»i; ivscits; i l rnciEis: srini: IVKJ: tosti; i I B«»is; coHrumn mtairicis: sti.- i i ICSHSIC wmcim i l i 1 l a) 1. 2 « or - t.« 1 ») Bales I TuUwa, «. 04/9 (net nt) \| t) r«nl«s \| Sniaki-UBttMto, i. b) 2. 6 » or - 3.6 j I liana, X. "9/7 <«et «t) \| Pro a «couf of «1 autopsies, I Teral, 5. 1 forensic Mdlca.1 araiiutlDU, Japan. 1 1990 I Bales, Mai age 40.6 Tt. Feules. I Irckirea of 1 * O. 80 • or - 1.6 /j {»et lit) «V1 a) Rales 1 tataiw. B. l\| F«eal«» \| S«aa iq« 37.* yr. \| iBTiromatal Bealth I 35\|1):3»-a TSICI nilltltS; tOtOPSIiS: JlPif; \| iicama: issMic: CIBSIDB.- cosuT: i CBBCdlO!; CCEPCf; I Mr: BIBCBET: \| 3ICI5J!; usnsiua: MICIIZSZ: t fUBIBItrS; »»IISO»T: SCHBIOH: \| stLmai: iniiros: Tuinusj sue; f «C1C; BiOMH; 1JTBE; nniHS; I CttlBIxt; C»Z9IUna; aXIBI; BOfClSS; I IIKSltS; SE1KI; LtTIGS: ICB«; C »»I115: COIPUlTln ITilBHICIS; SEI; I Kfiisxc srciciK i 1 12 aaiplae \| laawson, T, ClT«et J«t«Tll»atloa «»a •its&ctio i liAnsto, 1. icocedvces a^re. } 1979 1 Clinleal Ckesistrj ItlJers, qario pnraiMl and pgttj l 25(11) : 191-1953 letters ta s««dik airplane factor. 1 t iiosniit icixoiioi: coBtuniti i nnoitiois; ciosiDB; s«!»l»: jtotTs: l HOCV; i»lil; BtoiccninrLMIoi i , ,. . , « OO ------- Cadalaa 7MO-43- C* Itr 112.40, IP 321 C, IV 765 C. n 1 ae gg at 3M C. 10 •* Sg at 486 fCOITIIDEIl) tissn 3725 Dilne 312* Urine 31TI Orlae 312* Brine EZpoSBBB BOOM Iggestloi Ingest Ion Inhalation auiRlcii H FT BOD US BVBBEB OP C15IS •t 34 b) 38 0 22 d\| 20 b» 15 c) 24 41 t« e\| 19 0 7 9) 21 hi 21 1 UBCB a) lot gives b) lot given e) lot given 1} Bot given a\| lot given b} lot gl?T4 Tr. Ccitrola fcot IsnitiH Prefect ice. Ige* SS->10 ir. Creetltine clearance and « reaal (icctlioiaa Eeaisocotloa decreased algalfleaitly in cd-eiponed subjects. rrcteinorea, gloco«rea, and J1PII; aOOITS; K10IIT BISIaSES; BIOOD; VBIII; EIOiCCOStTLKIOl; iETlt toisoiiis: tins; IIDJSTSIH tcmrtioi; CIEBIOH 1 Tevlea of research la Industrial aea for aad envlroanental effects of Cd, as reported by the International lead Zinc Orgaailatioa. Hint; CH8IBR; HBT1LS; lEISVtnnt IIIBODS; II TITO IIIITSIS: BIOOD; ifin: EIEIIT DISUSES; BOII HSElSES; OCCOPUIOU1 DI5B1SBS: FOPtmtioi tiposnB; iinosiiiit ECIURIOB a) Coys living < 1 k» froa naelter t] Sirls llvlnq < 1 ka froa saelter cl Coys living 2.S km froe enelter d) Girls living 2.5 ki Iron enelter e) Drban tovs f) Vrbai qlrl g) Ural boy: M Imral girls tatlaatel ftca graph School-age chilicei living nenr Pb tnelter in Belgian. Controls froa rntal anl mean areas. Biieaitsi: cmsios: usiiic; IESEIIC CIG1BTC COBPCOIIDS; CHUBtli IIDOSTIIlt tlBDSPKBlES: SailTESS; EIIILS; BIOCD; V1IIE: BEtSIJH; TCPULiTIOW EIPOSOJB: EOH1 tlEaS; IBEII tins teunc«4 7 S to it a,f.t«r einosc« letopsy specimens. Battery elate »k ------- CalaiM T»9-»3-9 C« HI 112.10, BF 321 C. It 765 C. H» 1 M B» at 39* C, 10 Bg «t HSSOt EXFOSBBt IOOIE nunictL HKTBOB \| HBBSS I Of ClStS \| ttia eimii iiroKimoi IlfZUlCl 372» Dtlna a) 70 b) 60 a) o. 002-0. t5S ag/br b) 0.015-0,365 «o/kr I a) 0.00 » or - 0.00 aa/az: t b) O.fl»3 » or - 0.007 \| tto/kc ( (S.S.) I I I I » •1 Coatroli c) tesideats of pollute! area reaea. »* age »2.3 ji, froa Cd-polleted area Ui?e>, lad coatrols, a«at aoe B1.1 rr, froa ttarlerol, Belgige. BIOOO; StOOB FIA5U: OBIII; CJmlOB; nit: iiicntT: tiKs smis; sstetvxi Kit tantuioi KVosnK; iicnsniii PCIHTTIOI) SltllHS; KIBB1T CISI1SES I l«ol«rjs, B. I »oel«, B. I Bernard, t. I Backet, J.f. I 1980 t lateraational IcckiTe I of occupational and I iDTltooMBtal Vealtk I «SlZ71-27 I I I 3730 Urioo lakalatloi lot applicable ( 2000 naoVl I I 30 aia aiEoxan I lit«iortt letel < I 3* rr oU ««i4«r t 1 Caatk 5 Jan after exposure. long cfeond ciangea typical of acate Bimi KiicicB: mini: tims IOI6S; mil; BU1TB B1I1KBS; gRtt, FCISOHI6: iitusniii ITIDSFBHSS: lioit»Tic»: ccctrpirioiu. MIIBIIS; CltitBB: HTatS; iffTOPSIIS I I Local, P.I. I Jarivalla, i.e. I Jones, 3.B. I sough, j. I rale, t.T, I lancet 2(81aTJ :205 I I I I I I I I I J731 OClB* InialttKu a) 60 b) as O 7* a) 0.015-0.365 nij/lir b) 0.012-0.T19 OJ/kr c) 0.002-0.ISt ia/ar a) 0.077 aq/hr b) 0.047 ag/br c) 0.030 «g/hr Geoeetric («»t (dilated I I at lesUeata at I a real f t) BesUeit* of Brussels (less I Fcllaved tr«a) I c) teslieats of Charl«roi (ceatral I lie** resldects Uffervd ftot Caarleroi fp(0.01) tat tram Iraaeals Malta* sabjccts >SO rr old, f tft« m»mf ar«as 2S itniTS; let; BLOOD rusai; ff»I«!; eitSIJS; IIIB; SIECOEI; eitiis; me; mtsTRiu BBISSIO»S; IfDHST>Ilt fCtLBTIOI; POP0tlTIOI I Eoela, B.I. I l«o»erT», S.S. ( Bucket, J-P I Bermard, t. I 1981 I ZaTiroacutal 3esearch I 24:117-130 I I < I I I I I I I I .1 I 3732 trrla* a.»-28.5 oo/l tot glr«» tpo»ti 6-30 ItNTS; BIOOO: ID1ETS; VSIIE; H tin ifUTSiS: lusnsnix anfcss: cionti: occvFHiorii BHMBS: amu f IHqraa, L. I Mttsaoo, S. t Pariica io BedlciM I Btolwjf 2«(1):1»-2« ------- 7MO-70-I ca It 10.OB, IE 850 C, SI la«0 C, TP 10 M Eg at 983 C 1ISSII 3733 Blood 373* Blood, seras 3735 Braia 373* eraatli EIPOSOK BOOM Inhalation UllRlCtL OETBOD us us Fin niBSS OP C1SES a) 260 b] 2«0 3 1 MICE «) lot aiTat b) lot , set. laagtk of reside DC* , aarital and •coaoale at at as, occupation, noaber el ckildran. sacking habits, ht, at. la kacd-eatar araa. aloaificaat Itctaasa ia ayperteasion, ice ataoraalitiaa, aad krperKieaaia. iiisis: aissciBij isnis: CItDlOTiSClnM DISBUSS; nrrnnsioi; BLOOD SEIVB; CCBPlSlTITt ITILDIII01E: CIDBIOi; CltCHS; CtlCllni; IMBWS; iieiism: IBOSPEOIOOS; pmissioa; saotoi: TIIC-. BIOICCBSOIHIOI: CII1S1K lt» a) elotraa pallliD«, 11 saaplvs. ecctetclmt of rariation (CT) »0.« l\ Catdat oicleis, 13 aaaplas, CT 3S. 9* c) Pataaan. 12 caaplas. CT 33. Of 1} Salstaatia nlgra. S saapl«, CT 1.t« «t Cerebtal cort«i, 17 saaples, CT 43.0f f) Eippooaapas, 13 saaplei, CT M.6I IttgpST saatles CIEIB5U COitITi SE1SUSMMI RSIBODS; citctOB; cetitij IEOI; Riieiizsi; nail: IOTOPSIIS t«Tal9 aftar «Tponc« to aerosols of c>a,lk dust froa blackboard erasers a fiactloa of cartlcla alia. latiaatcd trca grapk. Tidal volaaa ol about 9CO c« a aid respicatorr frequoncr of 1! cycles/alt aaiataiand dtrlag taapliag tlaa. EtllTB: BKCinz; C1LCIOB; CBLOKIITB: lilt: koTOionrt: ixiosraiEE: KFUnCE Cootlmrn, t. Baltoa, I.I. larria, B.J. Giles, R.I. trovii, 3.K. Taraer, TC.L. »111iinso». I.e. Tortar, J.O. Barrie, M.I.H. BcRaf. G.S. roeock. s.j. isao British Badical Joarnal 2<1(<232):11-14 Biaraabaee, R.I. riaischaan, I.I Oann. 3. 1975 lAnca-t 1(1»1«) tlOOI-1016 Goldberg. 1.3. 111m, l! 1981 Clinical Caeaistrj 27(»):5t2-5»« Des«daleer. S.S. Riackaater, J.I. Environmental Science and techaoloqi 9 (10): 9 71-972 (BEIT PIBE) ------- Caleian 7MO-70-2 Ca Itl 40.06, BP 850 C. BP 1440 C, TP 10 •• Hg at 983 C (COHTUOED) 1 IISSUE \| EIPOSOBE BOUTE I 1IJI.TTIC11 HtJBEIB \| BalGE BE1I \| SBBEBll IBF08H1TIOB I SEFEBBICE 1 BETBOD OF OSES 1 1 1 1 1 1 1 II II 3737 Inhalation FIXE 1 \| lot given 20. 1 ng 1 « 1 sanpled at rate of 1 1/nin, 2-10 1 Ikselsson, K.E. Breath \| \| iln after burning * arc velding rods. \| Desaedeleer, G.G. 1 I 1 Johansson, T.B. 1 1 I University physics shop, Florida I Winchester, J. B. Ill 1 1976 1 1 I ftCBIDl: HOtTS; BHEaTH; C11CIUB; \| annals of Occupations i \| CCIOXIRE: CBBOKOB: COPPES: IBOI; I Hygiene 19:225-238 \| \| IIJD; MIGIIISE; IICKEL; POT JS Sltm; I j I soxFOR; tiTHiuB; viHiDiOH; ZIBC: IIB ( \| \| PCUDTIOI; FUSES; IBDOSTBUL \| \| \| MiOSPBEBIS: TRICE EIEBEHTS \| 1 1 1 1 1 1 3738 US a) 31 1 a) lot given a) 397 ppa I a) learning disabled I Pihl, B.C. Bair b) 22 I b) lot given 1 b) 311 ppa i t} Controls I Parkes, B. 1 1 1 1»77 \| I 1 learning disabled and nornal 3rd and I Science 1 I I 4th grale students in Canada. 1 198(4313) :204- 206 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3739 i 1 \| 1 I 1 I 1 1 1 I 1 I 1 1 1 lair 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 f 3740 Bair 3741 Spinal cord n X-ray spectron 1 a) 42 b) 40 7 12 a) 63-1501 ng/g b) 77-2068 «g/g a) 29.9-94.1 ug/g b) 17.2-66.3 ig/g ry t 1 1 \| ClICXHR; R1GIESIOR; POTASSIDB; I 1 seems; CIOBIDB; COBU.T; COPPEH: i \| HOB; IBID; BaRGalSSE; ZIBC; \| \| CBBOBIOB; LITBIUB; HE8C!JBIi BET US: \| I BUB; CHIIBBF.I; CllaOa I 1 1 1 1 1 Beviev. 2 representative I Chittleborough, G. 1 tre-analysis treatments are 1 1930 I tabnlated. The feasibility of a I Science of tbe Total 1 holistic, so-nash policy for hair \| Environment 14:53-75 1 analysis is outlined and sgpported. I 1 1 I BEVIES; TB1CE ElESEITS: SUB; \| I ltSTBU.Il; RIaStTBEBEBT SEIBCDS; \| I HTHS: PBOIIHS; COBP1B1TITE \| I MllOlTIOBS; IIOBIBOB; 1ETIBOII; I 1 iBsiiic; itaiiTB; BEOaiiz: CIDHIOB; i 1 CIICIBI: CBICBIII: CBBOHIUB; COBILT; I 1 CCPPEB: sunns: GEBBIIIOB: GOLD; i 1 ICSIIE; IBOI; IIITBIIVI; LE1T; \| I E1SIESI0B; BIBGalESE: BESCHBI; I 1 ICLISOEIHB: iicKiL: {BOSPBOBOS: i 1 fOTISSIOl: EOBIDIUB; SILEIIUB; I 1 SIIICOI; SIITEB; SODIOB; SIBCITTOS: \| 1 SOIFDB: TIB: TirinaB: TDIGSTEB; i I me; ZHCOIIU8 i i i l i a) 26« ng/g 1 a) Controls I Ryan, O.E. b) 210 ug/g \| b) Stltiple cclerosls patients \| Holibecher, J. ledians 1 Sanples fron 7 scalp sites in each I staart, D.C. 1 cnbject. 1 1978 I I Clinical Chenistrv I C1I1DI; IDniS; CEBIB11 BEBVOnS \| 24 (1 1) : 1996-2000 1 £1SIEB 3ISE1SES: H1IB: ILHSIIOB: \| I IBCSIIE: cucnm; CBLOBIBE; COPEEB: i I ecio; IODIIE; niGiiiSE: BETHS; i I SfLEIIfl; SIITEB; SCDI8B; SBimB; \| 1 I1«10I05I; rllC 1 1 1 1 1 a) 54.7 * or - 27.9 1 a) Botor Deacon disease patients I Rarlander, B.B. ttg/g \| b) Controls 1 Patten, B.R. b) 35.0 » or - 15. 1 I ventral horn tissve. aatopsy 1 1979 ug/g 1 1 Innals of leorology Dry lit 1 Patients died of nyotrophic lateral I (1):21-2« 1 sclerosis aad progressive sescnlar I 1 atrophy, nan age, 58.6 » or - 13.1 I 1 ?i< Control: died of various 1 1 diseases at (0.9 » or - 11.1 yr. I 1 1 1 1MIS: 10DL1S: aOTOPSISS; 1 \| IMSOimCULIB DISUSES; SIII1L COBO; \ \ cioiccvimtaTioi: citcimi: cotpii; \ 1 IICI. ItlCs IMCanSf. ISTlUt \ \ siitirm IIK i ------- CirtxM tatcacUocid* II CI) tataait. tctucUoro- n CI) ««-23-S CC1* !I 153.8. IP -21.6 C, BP 76.8 C. TP 100 » Bg »t 21.0 C TISSUE 372 Brtatk KfOSOtt BODTI IHITTICU BITBOD ec-is BDBBM OF ClSES 54 (397 BMSI lot aivea U1E 1.4 ag/1 GIBIB1L IBFOllallCB Samr<4 at 25 c aid 7SO » Hg M.~n occnxitace Icier a«d «p«t oae-Sigaa Halts 0.»3 aid .< 14/1 Bealtar. 19-35 ir old, noeaaoklEK], •eta* blieka aad eaaeailaas. Cklcaga. 11. Bigldlr controlled aipcriaaatal ooidltloas. flllTB; 11CCB01S; ILLIWIS; 1D01TS; CtlOtliniD BYDBOCHBO1S; TOUTILI ciGiiic coipcinos: BUITB HIZIIBS; fO'BHTIOl IIPOSOBI: OBBll 1BI13 BEKBEBCt ECOtOSXIDSkl. B. K. Brnneav. G.I. C< Belli, H.J. 1979 Joacaal of inalfttcal Toilcology 3:225-23* Ctlill CI It* 132.90SI. IP 28-5 C, BP 70S C. TP 1 •• tg at 27S C. 10 ai Ig it 373 C TISSUE 373 «UMT HPOSTOE BOW! iiumcu BET BOD » main or C»SBS i) e b\| S c\| 12 utei a) 0.006-D.058 tg/y i) D.OO5-0.064 ag/q C) 0.009-3.057 ltq/9 fet »t <»BIT Bill a) O.OU ug/j b) 0.01T 09/9 c) 0.021 ng/9 let vt Heliats PUSH emut iiraiiiTioi a\| coitrolt b) (atfccr itoop I cl Mt»«r gicap It t«c«»«d rtfiaerr ud ia«lt«c norkecs. ag«a 55-76 ji, exposed to k»T ««tal« 1-3 decalo. Tiie tctiee cetimeBt and death 0-1. S yr 1> gro«p I aid 2-19 TC, gcoa; II. ccatmlB. a«es 13-72 re, vio lived SO la fro* «« factotr. S««d«m. S»m: CICITIKS; KIDIETS; LITE1; IOISS; COBMUTXT* BTlltHTIOIS; IlDDSnial 8ISIEII: BStSOBIinT HIBODS; iniBOIl; 1BSZIIC; ClDIHIi CISIHB; CBtCBIDI; COB11T; COFPBB; coin: isoi! imiiiva; ins; tllCtlBSE; IIJCUH: tOtlSDimH; EtOSPBOtDS; IVBIDtnB; SC1IDIIB; smmi; sitTEE: TIB; toiesni; me: Bum Huuas; inmsniu fLktlS; SBttTEES; TBUDIIOI BIHBBIC! Brine. 0. locdberg. G. Wester, P.O. 1980 Scleoe of the total En»lroua«»t 16:11-35 LJ ------- Cuimi YUO-W-2 C Itt 1JJ.M5«, n 28.S C. BP 70S C. T) 1 u If t 179 C. 10 n 89 «t 371 C {COITHIIZII} iissoi mosaic tom iniRicu BSTSOD 37M U Unr t 1 1 1 I \| II 1 1 1 1 1 1 1 l 1 t 1 17$ I U laaa t 1 I 1 1 I 1 1 ( 1 1 1 1 1 1 1 t 1 1 I 1 •OBBEI or cuss a) 8 bj 9 et n 8 9 11 1 »MI a) 0.01»-0.05Z aoyg b) < 0.0010-0.01 U9/9 Cj < 0. J00«-t.0«3 t«/a ««t « \| a) 0.005-0. CM g/g b) 0.00-9.08 09/9 c) 0. 007-0. flSO aoyj tat t 8ii i t eiiiuL inratUTioi i a) 0.018 oj/9 1 it Control •1 0.3065 m/g \| tj loriar «til> 1-3 d«eai«. 1t» batMm r«tirta»»t aa4 teat* 0-I.S yr ia qzoap I aid 219 yx« orovp 11. 1 cos won, aaas «l-72 yc, «lo 11 wa SO 1 H froi tit factory. s»«d««. 1 I SfiDCi; ciaitsis: ciirtrs; HTM; IflSS: CO5P1MTII! mUUIIOIS; IICOSIBIH ireitii; ncison«»T tltSCBS; jRIBOIT; UStWIC; Clinvc ctsmii CBIOBHTB; couii: COPFII: eoic: ito«: imitm: aits flieimC; fUCBBT; SOLIBDHOB; EMSMOCVSs IQtlffrVB; SCJVOXDBj sntnov: sum; TCI: THKSTEI; tiic; HIITI HJiisrs: iiiosisni SliftSt SBltltBS; TCLtffSIOR I nnnict { 1 Br«a, 9. 1 lordoar. S. t vvvtar^ P.O. 1 1»8« 1 sct«oc« of taa Total 1 ZaTlroBMBt 16:13-35 1 rr 1 50 \| 1 1 1 1 1 1 1 1 1 1 1 1 1 i 1 1 Brag. 0. I lardbara,. C. 1 »«st«r, P.O. 1 1480 1 sci«c of the fatal i EorlroBMit 16:13-35 1 1 1 1 1 1 t 1 1 1 1 1 1 1 1 \| 1 1 Cklord C19-M-CI8 II 0.8, tt 175 C «t 2 » 1110(8-5) u «9 »t 25 C l rrsiM i l i 376 •Ilk l 1 t (TfOSPXt MtOTC laowtioa t i iraimcu SffUOQ oc t t t iraszt OF CUSS a] 21 b) 24 c) »S i) »5 1 1 t IJfSI a) 4-4.150 ppa b) 0-0.733 ppa c) 0-0.723 ppa 4) lot I t \ 1 , . . - ------- Chlorine 77S2-SO-S Cl Itt 39.753. SP -101 C. tt -3«.OS C. TP «800 u Bg «t 20 C. 1 •• Bg «t -123 C tlSSBS 37»7 Breath 37a freatk 379 lair 3750 Bair ixfosms MUTE lakalatioe Inhalation 1IUTTICU SRBOD rat HIE » man OF CASKS 1 1 «l 23 b\| 19 e\| «2 d) 14 •t 26 f) »0 11KB 8-0.005 ig/cn • let given a) 230-5(20 ««/9 b) 20-910 ««ya e) 20-5620 og/f d) 230-2710 og/g •) 20-2120 Bg/g f) 20-2710 ag/g BUI lot giren 29.8 na a) 10«0 ug/a b) 360 Ig/9 c) €90 og/9 4) 1570 ng/g et 780 sg/g f) 1050 ag/g sedians CIBIlll IBFOIB1TIOB Ut«r aitoiotiT Pb htlld* Mro«ol •iposvre. !«•!• a Cvaction of TKtlel sis«. B«tiHt«d fre* graph. Tidal TOllM of aboit 900 CB » and respiratory frcvnacy of 15 CTCl«s/ili aal«t>l>«4 dariag 10-aia saifliiq tia«. aiiiti: Btcnn; ciicxgR; cnotiiB; tut: igionmTS: WBOSJBJBB; tllTICILaTZS e 1 »aapl«4 at rata of 1 1/iia, 2-10 lia at t«i timing » arc «lliag rods. 0>l«raltT tkyslcs »hop. rlorlfta tUBXBt; 1E11TS; BBBIIB; Caicloa; CBLOBIBBi CBBORIVBi COPPEls IBOB; mo: BiBeiBisB; ncdi: KTCISSIDB: SBLFBi; tninoa; TMIDIOB; TIBC; in KJIIBTIOl: TUBES; IBDBSTIIll ItBOSPBBBBS; TH»C« BIBBEilS B«i«. 2* r«pr«ntatiT« Fr«-aaalTsi< tr«at«>ts ar« tafeilated. Ike fuilbi.li.tT of « kellitlc, ao-«a>h roller for hair analysis is cot lined and supported. itrixB; TBICI BiiatiTS: BIIB; HSnUIt: BI1SOBBEBR BETBOOS; IITILS; PBOIIIBS; COBV1B1TITI HHBITIOBS; UBBIBOB; 1BTIBOBT; IBSIBICJ B1BIOB; BROBin; CIEBIOB; CI1CIIB; CBICBIBB: CBBOBIOB; COBU.I; ccppSB; sutjDB: GSBBIBIVI; ooio: ICCIBt; IBOB; HBTBIIUBJ LB1E; BISIBSIDS; BUCIBESB: BEBCOBI: tetiBotna; BICKHS PBOSPBOHDS; MiissnB: BBBionia: SBLKBIOB; SXIICOB; SHVEB; SODUJBJ SIBCHTWH; SIIFOB; TIB; TITIBIBB; 30BCS1EB: MIC: UBCCBIOB a) Bale controls t) Tonal* eottrols c) 111 ccntrols 1) Bal« saltiple sclerosis patient* •) F«n«l« ssltlpla sclerosis patients f) 111 Btltlrls sclerosis patieits Staple* fros 7 scalp sites IB eack (ifcject ClBIDl; 1DBIIS: CIBTBU. BIBfOOS fisTEB oisBists: BIIB: UOBIBBB: MOBtBB; CIICIOB: CBLOBIBE; COFFEB; cciii xooiBi; BiaciBisi; HBTILS; StlEBIOB; SIITSE; SCSIOB; S01FDB; IIBIOIOB; IIBC HHSZEC! Oesaedeleer, 6.6. Vinekester, J.». EBTlronwntal Science and Teebnology 9(10»:971-»72 Ikselssoi. K.B. Desaedeleer. G.s. Jokasssoa* T. B. Winchester. J.B. 197« Inuls of Occopatioail Hygiene 19:225-238 Cklttleboroagk. C. 1980 Science of the Total Environment 1«:S3-75 Byan. D.E. Bolibecher. J. Stuart. B.C. 1978 Clinical Ckenlstry 2«(11):199C-2000 ------- Cfclcrototi \|t CI) Catkua. trlchloio- n CI) «7-«S-3 C-S-C13 » m. 39, H -63.5 c, re 100 •• ig it 10. • c 1 1 1 1 r TISSUE EXfbsm BOVII i 1111101 I BCTBCB i 37SI OC/BS treat* 1 r i i i i r i i i i i 3751 1 ee-BS Breath i 1 1 1 l 1 i 1 TO a sra 1 or casts i 8 \| f \| 1 s* fr f 1 minis; ciictttiT» BIDIOCIBBOM: i CBIO1IBX OBEWXC COWOIMDS! \| CBlCflOSBaTZBifKrj FKFO9XVS COBPOVUkS? 1 isriiB: uccfois; THIS: (Dints i 23.3 ag/1 r Manrat at IS c «Bd 7CO •• Bg SaOMtrlc I «2- Tf oci«rMBc» I lerar «a PTr OM-slgaa lialta 7.» j ait 73.7 >g/l 1 1 B«altT> 18-35 yr olfl, •oB«aklag. I «t«a Hack aad ea>casia». 1 Ciieaqa, 11. ligidl; coitiollvd \| «p«clMatal codltlo». 1 \| E1IHB; ItCCEOIS; II1IBOIS; IDOLTS; \| CBLCSlrlTID eTDBOClEtOIS; TOHII1I \| CESlnc COiKITIDS; iniTI BlllBDS; ( 3IBMHICI; BETIEOUSS; gllaMlRBS; J fOMLITIOB timSDBE; nB» IBB1S 1 IMBSCTCI Cookl, J.P- CMP, ;.J. Mich. B.S. 1»7S lrchlr«» of EDTlrouotal Bealtk 30 (2) : 240-295 xrotoaimrtl, B.K. Braaeaa, S, «. O'Balll, B. a. 197S Jotciwl at laalytieal Toilcalogr 33 225-23 « l » CD 9 . W-5«oaeBi>lwu-S.7.131W] -Irlei-J-M, «»-97-a CS7-J<»-0 •1 381.62. H 8«-85 c I TIJSM 1 1 3753 I Blood, scrva SirOSBlE BOffTJ i i l iiiiTiieii 1 giriov 1 f Caipetltiw ttndiog 1 1 1 OP CISSS 15 \| BM6I 1 -1 - - i a] Pat qlrca t>) rot glrei cj (at giren 3) lot g-lta e) Bat jl»«a 1) Bat giT«n gj Rot glvu h] lot jtiei 1 Kit 1 fitlEIK I»rOSUTIOB 1 1 a] 2T «c - 3 atffi. 1 rt 2S-trdrciTTlt««i» D fi«tatollt«) , b] 28 «r - 1 94/Bl 1 15 CfcLldno lltb blool =t of 1D-24 c( 23 or - 1 og/al I o?/r£tuia 9 1 U-etiboUMJ, cUldrca is a] 1 f) 1.25~dUTdroxr>it»l« K/ etlllrea 1 In W I gl 1,J5-diliTdror7Tlts«io D, children 1 1 c\| 1 i) 1,2S>4tiTdroxrTitMla D. ehHdr«« 1 i» e\| <(t«c ckalatiaa tterapj. f I 1-5 71 old«. BT 1 { itii: f!Ti.m D; cinoiEr: in TOIK; 1 IlOCt; COBPtllTITE (niniTIOIS: BIOOO 1 SMOB; SETieciisB; smsoiiiis: 1 EIOBOIICBOItClIClrSBOlS 1 ftrtxaci 9039k J.7. Ctaner. 3-1- a««»tn, I. D«Ioca, B.T, !ab>ff€T, I.E. 1980 Vttv BoglaoA JoorD41 of HclidBa 302 [2«» r1T2a-iui ------- ciroaloa 7MO-«7-3 Ct Itl SI.M6, tt 1990 C, BP 2«2 C, TI> 1 u 89 at 1«f6 C, to •• Bg at 1ft«0 c 11SSM 37!» t«I«Ul ala»d 3755 lort 3756 lorta 3757 Blood, plaaaa BIPOSBBB BODIE 11UTTICU HFTBOD us u us BOBBBB or cans > i > 5 3 •1 1 l>» 5 S1BGB ) lot glna ) 31.5-156 ag/a »«t .t Boa* tetcetti a} ik>t givu to) 8.2-13. C «g/g vat »t BUI a) 1530 ng/g wt vt b) lot gina Boa* d«tet«d a) 221 ng/g »«t t b) tot gl»«« GCICB11 IIFOIUTIOI a) lockvr b\| Controls JiCaneM ioTk«r, 65 Tr all, at ctiout* TrcdDClnq plant foe 30 Tr. tl«a of nxillaty ani lug canc«r. Cntcols, a««« !S-7« jr old. Jltal: IDIPOSE TISSII: UHIa; BOII IIIMI; Will; CISEBttLSB; CMItBOB-. IIIIR5: IlflEJ LOTES; SBSCIIS; (iicms; SHI: cnonaii COPPIB; situs: me; IIDJSTBIJI. piiiis; 1IB1HT10I; COCTO1TIOI11 B4IIBOS; fctraiiioi IIPOSOM lal«* Iroa a aroip of 61 Mtopsivs. tctcmic aealctl «xa»lutloM. Japan. Bills, nao aq« ao. 6 T'* T«aal«s, t«ai ag« 37.* yr. MICE ZlKIItB: IVTOPSIIS; JIPJI: iimmu: USEIIC: CUEIIB: COBM.T; CBtOHHS: COfPBl; IBOt; B1BCDBI; 1ICHJB; B1S1ISHH: DUeallSB; IDHDIHa: 1RIROIT; SCimiDB; siiinni: inuioa; TIIIDJUB; UK; CC1I; BSOSIH; lITtB: RIBHISi emnni: cnnn&tti; asm; IOSCIM; fiiCBiis; spun: miss; iant: B (TILS ; COIFllMIft ETHBIIIOIS; SKI: ICtHSIC BTG1CI1B a) torku b) Coitcols Ja(aa«M « octet, «5 TT old. at cktout* (lodocinq plant fox 30 TT. tl«d of aaxlllary aid lug caaecc. Cntcoli, ao«A 59-71 jl old. J1P1»; 1DI70SZ TISSUI; 10IT1; BOII S1BBO«: tllll; CISBBELtOB; CBIBtBn; IIBIBTS; illlS: I, DIGS; RDSC1ZS; IIBCBIU: StlB: CBBOilDB; COSPEB: EtTUS; UK; IBDBSTBIU PIWTSj lISKktlOl; CCCOPITIOIIL B12MD3: tCPOTlTIOI EIPOSOB! ItTla«. Protlsas IB risk analysis of e»er 1 Bl aid Ct ladmtrj at* pc««t«d. various coapoanda at* citvd (kick cana« eaacar ID practical ciponc* sltMtiou. n« iMd for 4oa* nfistxatioa Is «apkasii«d. ICBIH; CIBCIBOB1S: BLOOD PtlS-IJ; I«IS; IIDBSnUI HtSIBK; SETtBB; CBBomi: anus.- BICKCI; CBBCIIOGBI; IIOnSTItlil KBOSVEBBBS; IBIVSTBIES; CCCIPITIOIlt B1KIBDS; IBOFI1SRS BSJIIBBCB BTOdo* K. SlXDki, S. InrnTa, B. Beshiioka, !C. ueo IBtcraatioaal Icchivts of ooeapational and InTitouABtal Bealtk 46:141-150 YokaH, B. Swnki-lasitBoto, B. laano. B. Tecal. B. 1980 lrckl»«s of BBTiroBMBtal Baaltk 35(1):3«-B« Brodo. B. Sozoki, S. r«aia, B. (•abixuka, B. 180 IntxraatlODal irchiTcs of OccapatioBal aad BBTicoBBeatal Eaalth «6:1<1-150 •orsetb, f. 190 Journal of Toxicology and BBTicoBMBtal Bulth «(5/6\|! 12 W-1227 (IBM PIS!) ------- Ckniiu Itt 51. WS. Sf 1999 C, 3T I6»2 C. W 1 a* 8e at 1«1« C. 10 mm go. at 1MO C (comma) nssn 3TSi •ena' mostii mm i IIUKXCU 1 frUOD l US 1 1 amin aiaac sij» or cisss a) 260 a) lot ei.en a) 0.012 or - 0.002 b) 2CO b) vot 9iea ao/7 b) 0.03 * or - O.OOT ag/l 1 1 1 1 1 1 1 1 379* t US a) 1 laaa r W ' •arroa 1 ^ i i i i i i i i i i ci i»u. nramxioi unurci a\| (aaeii CItr. JU. aard-nater area Bieraaba«.a. B.I. b) U>MS cttT. >, aaft-atec area nelackaaa. l.T Siaiificaitli kt^ker lent (r<0.01) Baaa, 3. it »ft~«tex area.. Inold, J. UTS IS «md 10 reeldeate aatcked far age laacet (aeaa a«ea 37 aad 3T.7 rr\|. eex. 1(\|eia)s10M-loU lea«tb of realdeac. aarltal ud eceaoetc etetas, oecapetioa, aeabec cf ekUdrea, «aakla« kaMtcv kt, »t. I karl-aater area, etoaiflcaat irereaee la fcrvertMicioB, ICC araorealltie. aad krpererlceala. R1VSIS; BYSSOVBXf AOVtTSi CIltlOTMCMII PISIISIS; • CPfTnSZOa. BIOCD SBKOB; CCIMUIin CTIIUTIOMJ C»ntl; cticnii ciionofl: HTBHTBJ B1B1ISIBB; HOStBMOISl KlllJSIinrs SCBIOT: tnci BiotceanuTtci: cittrraa ntn ) lot flrea a) 51.3 nj/g a) tarter Irada. X. k) lot alrea b) 22. aa/a \| >\| Caatrola s«nkt. s. et rt 1 tmtni, 1. t \| JapaaeM eercar, 85 fr old, at »«»W»o«, I. t 1 caraeate trolacijae plaat tex 10 yr. 1580 I \| tied of eadllarr aad laae caacer. lateraatloaal IrcUves \| crttcele. i««d S»-7 fr «la- «t OceapxtloBal aad. 1 A)TlroaMtal Bealtk Jin»: tDirosi TISSBC; ioHa; Ban (iiian nuit cnnutDB; CIIJBOTB: l f i UBiBTSj art} utesi aosctis; f 1 1 »»cMis; am; cnanaBi ccrpsi; 1 1 MTI1S; tllC; IIBIBMIU. FtatTS; 1 II IBBIUirOlf CCCtrfATXOVll BAX4EDS: 1 1 t 1 CCFOUTIO tmsni 1 1 11 1 til I 3760 1 in f la) ne detected a) Vane detected a) Rale, cerebraa, 8 mbfcct* 1 Irata 1 1 II 1 1 1 1 1 I r l i f t l i f 1 I b) ftwe detected 1 »\| teae detected t) feaale. ceratne, « nb^eets 1 c) me detected 1 cl Baae detected c) Balea, eacebtllna, c aatjecti 1 d) loae detected d) >oae detected J) teeale. cerebellaa. • avbjecte \| 1 ftoa a arm of ft otop«l«». 1 1 (omsle aedleal exaelutioM. Jffta. I \| la]e«, aeaa ao M.t Tr. rtnles. ) 1 aeaa ao« 3T.< rr. J 1 II1C1 tLBBIIU; inorsitS; «HI; I utRna: Msnic; cumntt; COBUT: t CEfOBHTB\| COPm; IBOV; BBBCKBT* I IICIUB: iicftsiaii tuetitsi: l mime; iniBoir; scuvrirf; i Jiinimij tnmiB; nuviai; &K; l sotr: noitBii imi; nrans; l cttinni; cfianui: axiit: TOSCIES: I F1KIII5J SIUBI; LDIGS; 10 lilt I BtlllSt COBflUTITB >TUIltIC3; SIX; i music Bmcrii i «:t«J-!5O Totaaa, V. santl-laaaaoto, B. tent, v. 1910 lrefcias of rnriron»eat»l Eealth 35(11 :3«-aa oo ------- ciroulM 7MOM7-3 CX Itf SI.99C. IT 1900 C, BJ- 2CI2 C, It 1 mm ty at HIS C, 10 •• 19 at 1WO C (coiTUoiD) IISSBI 37C1 Bra la 37(2 Bxaath 3763 Bair 37«a lair IUOSBH toon laaalatioa IBaLRICll B2TBO0 US mi us BUBIEl or cuis 1 a) 31 bl 22 •JICI a) 1st glra b) lot glT«> e) lot gink d) lot glr» lot gl»a a) lot given b) lot give •Ml a) 62.1 »g/g bj St. 5 ug/j e) 5&.0 >g/g d) 19.5 ug/g lut «t 9C.« ag a) 0.25 ppa b) 0.09 ppa SEIIUl ZITOIIITIOI a) lorter - ocbcaa (teaporal) fc\| lorter - cenbra* (occipital] <\| lort«r - e«rblla> d) Coatrol - ecbrua \|fxotal lob) Jataaaa vorkar. 65 yr old, at cbcoaat frodncinq plaat for 30 Tr. tied of aaxillacj aad Imng caac«r. 5 cntrola. aqu* !»-78 yr. J UII; llirOSI T1SSDB; 10BTI: BCIS Biiioi: n»ii: cniBEiioa; cniEni; me BETS; inn: HISS; BISCLES; Tiiciiist »iis cnonoi: CCFPII; BIMIS; IltC; I1BBSTK11 PlliTS; IBlltlTIOl; CCCVI1TIOIIL B1I1IDS: icttUTtai tirosots * 1 aaaaltd at rat* of 1 Vain. 2-10 ata after baralag * arc nlding rods. Bal»«r»lty ptyulca akop. Florida ItOIIDIi aEBlTS; BIIWB; CUCIOI; ccioiiR; ciwiios: eoppii: iioi: HID; laicmss: sscsns Miassim: SUPBl; TItllin: VillOIOg; CIIC; III iciioTioi; ions; XISDSTBIU niospints: inci miERS a) learulag disabled t) Coitroli l«araiaq ditibled aad aoraal 3rd aad ata grad* tadats la Canada. ClICIBl: •aCIBSIDI: (OI1SS1OB! SCCHa; CatHTOB; COBU1; CQ»SS; iioi: ii»; iiioinsi; me; CIIOINI: tltlTOB; BIB CUB I; IBTUS; •Hi: cniDKi: ciiua lel«. 2 xprsatatln tt-aaal7tla tratata ar tatalatd. Ik feasibility of a kellstle, aeasa policy for lair «»»lyii» la emtltd aat a«pportd. ItTIEl; TIKI IlialBTS; Ball; KSISllIl! lUSOUini BITHOOS; mus: iioiins; COIMUTITI imnnoBS; iioiimn: mnoiT; llSIIICi BlltOB; BSOIIBEt CIDBIOBJ ciicim; ceicint; cnoBivi; coaiiT: . «.t. Da>adlr, 6.G. Johansaoa, T.B. lack«tr. J.I. laaal* of Occupational Bfglu* 19:225-238 Pihl, 1.0. Parkas. I. 1977 Science 1«B(313):20«-206 Chlttlebocoagh. 6. 19BO Sclano of the Total Z»lreiM>t Hi 53-75 (I1R PISE) ------- Clrealia 1MO-4T-3 CC itt si. Me. n 100 c. tr 2««2 c. T» 1 » l« it 1»!6 C, 10 •• lg at 18«0 C (COVflKFED) 1 1 1 1 1 1 HSSBI MPOSBBS BOOTB 37«S Balr 1 1 1 f 1 1 l BFTBOD 37(6 f M ••art \| 1 f 1 1 1 1 1 1 < t 1 1 1 f 1 / 1 i l 1 I01BSI or cis •) 8 w 1 1 * 3767 \| U \| a) 22 fitter 1 1 b) 3 r i i i i i i i i i t 1J1GI a) lot gives b) Bone detect*1 lot gives, (one detected iiai i eiitut iiroiBMioi i IBRIBICB i i i i I 1 rsvlev of iiorld literature o tie I Jaailas, D.s. I aecMnlatlra and blocoBeestratloa of I 19T9 I selected toxic trace seta!* la tnus 1 E>a-«00/-7-09, It 1 ktlr aid sells «al a tier sessallu 1 pp. 1 bait, far, atil, clavs asd tools. I I Jaiolated by geographic area, 1 1 »t)ects, sex, ge, expomte 1 1 gradiest. asalrae* la pp», and I I aatbaritv free over 400 reference. 1 1 t 1 MIICI: iistiuia: cauoa; czniu 1 i itznci; tncns HBSIB BIST; n t \| tZallES; SCm IBXBICl; SOOTBJ1ST 1 1 ISI1; BIXTFD KTK9OI; OII9I9 ST»BS; I 1 iui; mis; BETin; irriBOtr: l I MSS1IC; BOtCI; CIBBI3S: CBtOBIOBJ \| I CCtJttj CCPFU; LStDl IBBCB1T; 1 I iiciEt; sntiiOR: Hi; Tinnraa: UB i l fciivrioi; inni pojonnois: i I HOlCCIBBIltlOI; BIOIIDIC1IOBS; IIIO I 1 iciiDiioi: reroLaiioi titosvtt: ttttt i 1 FOtionoi : IBICB MiBBns: IETIU i i i l i a) 0.07 + or - 0.12 1 al tales 1 Tvxata. B. ag/g (vet «t) I t) resales 1 Sazkl-as»oto, 1. b) lone detected I 1 >e»o, «. 1 rros a Troop of 61 aatopsles, t Tersl, B. 1 (orsaslc sedlcal exaslaatloas, Japan. 1 110 1 Bales, eeaa age M. C r' resales, t archive* of 1 seat age 37.4 rr. { tirironaestal Bealth 1 1 35(1\|:3-M 1 tsaci ziBBtiis; iraopsiss: »»ai; I i aiontra; IISMIC: cuutas coiui; i 1 CtBOBTOd; CCfPEK; IBOir; MBCmi; 1 I iiEim; sieiismi; uieansE; i 1 MMDIJI: JIHBOBI: SCaiDIOB; I 1 Sllttttrt; TIIalTOB; MUDIDB; ZIBC; I 1 SOtD: BBOBI1Z; IITBS; (I9BBTS; I 1 CIIEBSOB; ClBtBEIIBB; BEtBT; BOSdlS: I 1 FJUCBHS; SI1BZI; HISS; JOBH: I I BZtalS; COBP1B1TITB BTlltJkllCBS; 5SX; I 1 fCBEISIC tit Kill \| 1, 1 1 1 a) 0.09 « or - 0.3 I ») Bale I Tatava, B. «9/g (vet vt) 1 t) resale I Sozakl-Tamsoto, B. b) lone detected I I Isano, K. 1 Iroa a groaf of 41 avtopsles* 1 Teral, fl. 1 forensic sedlcal exaslsatloss, Japan. I 1980 1 Bales, seaa age »0.« ji. resales, t arculres of 1 seas age 37.* rr* 1 Envlronseatal Healta 1 r 3SO):3«-«« l iiacz nEBtiTS: taropsiES; japi»: i 1 110BH7B; JBSJBICi CaOBIOB; COBU.I.- \| 1 CBBCBIN; CCtfEB; I BOB; REBCtJBT: 1 I IBOIOB; BaGBESXVB; U161BSSB; 1 1 ismiiB: IITIBOBT: SCIIDIDB.- i I sniima-. uiaiioB; TI«»DID«: ziic; i 1 CC1D; BBOBIll: UTE1: KIOBETS; \| 1 CZIZnUB; CZBEBB110B: BBaBt; BOSCLES: 1 1 EIICBI15; SFIBBI: 10I3S; 10M1; \| 1 sniLS: coB?uatiTB ETalvaTiois; SEX; i 1 ICBZISIC RltlCHS I 1 t lisn MOB) oo o ------- CftiMln 7««0-«7-3 Cr J» S1.99C. IP 1900 C, BP 2642 C. TP 1 » Eg at 1616 C, 10 •• Bg It 180 C rrssiri SS, 3769 Kidney 3770 tine 3771 liver ixposni sotnt iBiiTiicit RfTBOD 115 11 Bl iU tmtst or cases ) i } 5 a) B bl 20 a) 8 i 7 M 1 b) 5 la KB ) lot given I 3.«-22.2 og/g vet it a) < 0.003-0.069 eg/g b) < 0.003-1. 14 »g/g »et «t a) Bot giien b] lone detected a) Bot gi^en b» W.7-38.7 ng/g vet at Bill \| SEBZML IBPOBBITIOB ) 128 ng/g net tt I t) rocker b) Hot given \| t) Control* I Japanese torier, 5 yr old, at 1 catenate producing plant for 30 yr. 1 tied of aazlllary and long cancer. I ccntcola. aged SS-71 yr old. 1 t Jltll: 1DIMSJ TISSOI; aOSTl: lOIS t B1BHB; BtllB; CIBmUIJB: CEEBESDS; \| BIOI1T3; I1TEB: 10IGS; aDSCIZS; I HBCIXU: sin; CBIOBIDS: ecipnt 1 IBBlllTIOB; CCCDPHIOB11 B131EBS; \| KTOUTIOI IIPOSD1I 1 a) lot given I a) Coatroli b) Bot given t t) Voxkeis. gronp I aad II 1 1 Itceased refinery and aaelter 1 vexkecs. age* 55-76 rr, exposed to 1 l«a»y aetala 1-3 decades, tine I Ei yr old. 1 I OIP»: aDiPoss Tjssoz; lOEii; BOB: 1 BIBtOV; atllB; CIFS3ELIDB; CIFEEBOB; I «mms: uytsj iJBss: auscus: 1 I1BCHE1S; SKIS; CBBOHlnR; CCIPSB; I irtiLS: 21 »c; IRDEISIHIU pxiirs; 1 IBBlLlTIOB; CCCW11I01IU, E1ZUDS; 1 ECPOTHTOB 1JPOSOEE imBZICZ 3Yo3o» K* Smkl, S. leshixaka, X. I960 International lreU.Te> of Occupational and ZBTironnental Health a: HI-ISO Erene, D. Vordberg, 6. tester, P.O. 1980 Science of the Total Znvironnent 1: 13-35 Tnleava, a. Saznkl-Iasanoto, S. llano, I. Teral, a. 1980 Irchlree of EiTixonnental Health 3S(1):3«-«4 BfOdo, E. Sllrti, S. rirtya, 9. 1930 laternfttioul Itcairea of Occupational and Zniironaental health 46" 141—150 (BEIT PaPI) 00 ------- Ckroaln 1MO-47-3 Cr »tt 51.»»«. 1* 1950 C, BP 2M2 C, TP 1 » Hg at 16U C« 10 •• lg It 18«0 C ussti 3772 liMT 1 1 3773 l«e 1 1 1 1 1 1 1 1 1 1 I 3771 1 l«»9 1 1 ! 1 ixrosni tom 1 1 1 i i i I i i I i I i JkULTtlCll BETB0D U u us ( mm or Cisia a) » b) 21 al 3 » ^ MMI iu> i ctBiBit iiroiiiiioi i nrxsncs i i i i i i a) < 0.003-0.11 »s/q a) lot gir« I a) Cntrola \| Btu«. I. b) < 0.003-0.23 »a/g b\| lot aim I 1) (ork». groip* I a«J u ( BordlMta, G. l«t »t I \| v«it«r. I.e. I ttcMMl rcilMrr a»8 Mltx \| 1930 I nrkvrc, •<)•• 5S-7t jr. •xpow« to 1 Sclac« of tk Total 1 k»T Mtal 1-3 tecatu. Tt» \| nviconMtt 16:13-35 I bltvMi »titMat aad teatk 0-1.5 Tr I 1 It gro»p I ai< 2-1 jr. qroir II. j I Ccitrols, ag«« (3-72 yt, »ko Una 50 1 1 >• fro* tk« fictotf. Sv«a««. \| I SIIBII; C»)inS; CIMITS; tlTSB; \| I IBieS; C08PH1TITB WHOUIOIS; 1 1 IltDSnill HGIXIS; SMStJElSMT I I i iRiooi: iRiJoir; iBsiiic; usnua; i I i CZSIBI: cnonoR; coatu: cant-, t 1 1 eOlB; noi; tHTMigi; IJIDJ \| t I MKlltSI: BttCBlI; SOITBBJIOB; \| I \| IMSPBOIVS; IBBIBIITSJ SOirlOB; I i i attnm: mnts ni; roiesnit i 1 i tncj SJJITB HUjiri: neosniM i i i CHITS: sntTos; numva t i i i it ( «) 0.27-1.2 09/9 \|Mt .t) \| a) O.SS » or - 0.»6 \| a) 8al« \| Takan, 1. I Ma d«t«A«d 1 ag/g (««t nt) I t) MiaUa \| Saxakl-Ia«aoto, 9. 1 b] Ion* tetoetcd 1 ( laaao. I. 1 1 tto» a qcoap of 1 aatopcix, I t«ral, 8. 1 1 loraaslc ndtcal naataatiou, Japac. I 1980 1 \| lalm. Maa a«a «0.f Tr. r«Ml«a, { lrcfcir«a of 1 I Maa a«« 37. « rr. 1 Enriroaacittl Bcaltb 1 1 1 35<1):3«-a i i tiict ninns: utopsns; JIP>I; i 1 i iinnmi: iisinc; cionoi; COBUT: i i i cnonrai; ccmu IM»; »tcnT; i 1 1 IIDIOI; RieitSIHRj IM6II»: \| I \| BOBMIUS; tinaOIT! SCMPID9: I i i siunoi; tmnvi; nuoiiu: me: i 1 1 etlD; BlOilll; tITUt IIDIttS: \| l i ciMBius; CEtnin.ua: BUIT; HVSCIBS; i 1 I FUCtflS; Sfirai; IITKS; IOH1; \| I i Bims: ccBfiwTire naioniois: ssi; i 1 i fonsic MticiM i i i i l i J - ~ ») lot 9! TOT \| a) 7100 ng/g I a\| Iork«r. rl««t «r;tr lob« ( Byodo. K. t) lot gi»«i 1 b) «S30 »g/» \| t) (ork«r, ri^at aidU lob* 1 Sntrti, s. c) lot aiTai \| .c) C1C mg/g I c) forkcr, right lo««r lob* \| rtriya, I. 9) 96.9-293 »g/j \| i) lot gir«B \| «) controls, right iepr lob I BtsHinU, K. »> 204-2»1 ag/g I e) lot glraa I \| coatcolc, rtgbt alJdl lob* I 1980 C) 19.3-13* aa/g \| fl lot giTeB I f) Coitrols, cigkt lo««r lob* 1 Ktcnatioaal IrcklTM lt «t \| (at »t \| \| of occupational ana t I Jaraaaa lorter, t5 Tr old. at \| EBTiroamtal Baltb 1 1 ckroaat trciocla? plaat for 30 jr. 1 «:1lt-tSO 1 1 ti«a at MXtillaiT aai long ca>«r. I 1 1 ccatrol, «g«a 5«-7l ri oil. 1 1 1 1 1 i Jim; iDiPosi Tissnj; IOETI: sets i 1 i BiiBoa; BBHI; cnntuw; crasspoB; i l i mtiEiS; IITEB: LDIGS; HBSCIIS: i 1 l iiicstis; SKI; cnonoB; cotrsi; i 1 l prtiis: Hie; IIDDSIIIU. PlirtS; i 1 1 IIBWIIICl: CCCVPlTIOItl 11I1BDS; \| 1 1 fOPTClTIOl HPOSni \| 1 1 1 (HIT PIG I) oo ------- Ciroila* 7«0-«7-3 Cl Itf SI.996, ir IMO c. tr 2C«2 c, rr i u 89 t i«ic c, to •• (9 at isao c (COBTIVDED) IJSSOB 37TS 1.19 377« Mlk 3TTT Ba»Cl« 37W .•••el •iiosnc Bom IIUTTXCU ECTBOB n us u us nrnzt or CISBS •I a b) 9 C) 11 al « b) * 1 I1ICE •) 0.025-0.72 «9/iJ b\| 0.07-1.75 »9/9 c) O.OSI-H «9/9 «t wt •) 0.23-0. « «9/l b) 0. ta-O.a; ag/lai c) 0.19-0.t9 >9/il 4) 0.1 3-0.. ag/J«i a) lot 9l»« »J tot «ir«» lot gins •MB i «mm iiroiBiiioE i i i •1 O.M2 19/9 I «) COBtrol* b) 0.32 »9/9 \| t> tartars, 9ro«p« I «•« II O 0.14 tg/g \| I«t t \| r«C«UWlt«t MAltll \| 9« (3-72 yi, «ko li»wl 50 I »• froi tb« teetoiT. S»«i«i. 1 inon; cigttms: tioins-. ivrn-. t mesj CORMIHITE Emuiiois; I niasniit ITSI«K! raisotum I iRWDS; iniioiT: usnic; CIDBVB: 1 ctsni; cBiotru: ccuur: corpii; i Kit'. licit iimim: LS»D; 1 tiietnsi; mcgiTi niiSDinm; 1 itonioifs: IQBIDIOII scimira: 1 SHima.: SILTZBt III; TDiSStllJ 1 me; mill aituis: IIDOSTHII I tuitsj S9HIEBS; mtntzni i l ») 0.«3 » «r - 0.13 \| t) 10 (otktti, «-1t toy* IscUtlon •q/il 1 b) 10 Ufaiti. 8-H days oil b) 0.27 * or - 0.10 I c) 5 lottoT. «7-S4 a»r» laetatloa ag/aay 1 <) 5 ialut. (7-5* tay* old e) 0.39 4 or - 0.21 I wj/al 1 Batlmn a«4 twic br«»«t-I«4 imlaats 4) 0.2C «• or - 0.1* 1 It Mlu«. •9/aay J 1 em: uctHiOBi muw; cnoiini: i ttius; coarumTx irunmcisi I IlflBTS 1 a) 0.»» » or - 0.10 I >) lla 09/9 (nt »t) \| t) ?••!•• b) 0.07 » or - O.ia \| •9/9 t»t vtj 1 Iioi a qiomr at «1 »topxUi. I fot«Klc H41cal •xailutioal, Japai. 1 (aim. Mai .g» »0.t yr. T«aaln. 1 ••«• a«« 37. a yr. 1 I HIM ttsBiBis; inomss; JIMI: 1 iioiiws; iisnic; cuaim: COBU.T; I CltOBIOl; CCimi ItOlj tllCUST; 1 IigiOH; B1SBISIOB1 I1BU1ISI: 1 BUIDIVB; klTIBOIT; SC1BOIOB; 1 sncBini; utiiiBB: TiBioioB: znc; 1 SCID: BBO»I1; tlfBB; SIDIITS; I ctteanB; cnnxuti: BEUI; BHSCLBS; 1 flBCIt»; SP1EM; 101BS; lOBtl; 1 BRUS; C01FIUTITK ETaLIlTICBS: SIX; 1 fCtllSIC BEBICIBI 1 61.3 19/9 «t »t \| 1 1 dafaa«M «oi1r«c. 65 yc olfl. at 1 cicoaat [xc4nclB9 VUat for 30 yc. 1 tl«d of (axillary »ai luq canc«c. 1 JIf>«: »DIPOSK TISSUE; MITli BCRS t qum; niiBi cniBinoo; CESBESOS; 1 RISERS: LlTtt; IHBeS; ROSC1ES; 1 flfCHlS; SXII; CBIOBIgR; COPtll; 1 BITltS; IIK: IlDBSIlIIi fllRS; 1 JBBI11TIOE; CCCWIIIOIIL BH1BD3; 1 tCtQUSIOl tlMSm 1 unMsttt Braa«, D. •orSbarg, e. B«tK, P.O. 110 Sci«BC» of tl« Total EBTlroBMit 16:13-35 r«»p«l»U«a. J. Tmori, E. 1980 Kerlcaa Joamal of Cliaical ttttrltlom 33:229-2302 Takava, B. snvkl-Tamaoto, B. luno, X. I«r«i, B. 1980 Ircktres of CaTlroauntal Baalth 35<1\|i3C-M ByoAo, S. Sncki. S. rarvya. B. iMshiivka. R. 1980 latarsational iccUvas of Oocvpatloaal and tarttoneital Bulth «6:iai-iso lint MSE) "' • '• CO ------- Ctroaioa 7«40-<7-3 Ct »« M.99&, IF 1900 C. » 2645 <. n 1 n B» at ISIS C, M aa la. at UlO C (com i HID) HSSSJ BOVTI iitirricti iznci nnaa or ctsis GZHUI mosunoi 377* ••11 I t I r«rt« of world literature 100; 111 \| lOItOTrOI; JII811 FCPOHriOISf I IIOICCUIDIITIDI; BrOMOIClIOES; U«D I ICIITTIOI; TCfOiJTICl EXFCStBZ; FJIBS inci ELmns; snus 1»7» 1 PP- I I f 1 I I , D.I. I 3190 I call I I I I a) 9 t) 11 «0t lot 6.77 * or - 3.99 P" i) 4.23 t or - 1.25 I i) laaan » 1) B» I left ttnib I Ilso relieved: I ctbec eleaeats I I Eealtbr 20-«C rr olo< tnooa larcla of JO SKI: nits; iMiri! uonnra; \| IRMOIT; 1I5BIIC; BUIDIi ClSHlrB; l cuciBB; cssnu; caBosiuB: CCBIIT.- l ccpreB; etsttaatt SOLO; iso»; IEID; I B16I«SIO«: BIIG1KSI: BSBC0BI; I IClTIDtltia; IICKU; COT1SSIDI: I JOBIBI1H; 5HMIBS: SI1ICOI; SI1TSB; I Kaaabrocki. E.t. I Ksnabrocii, J.t. Sreco, 3. Oexter. r.T. I Brar, S.S. »«130B, D.B. Boon. c.z. UK; I Science of tbe Total I iBTlronaent 13:131-10 t I I I I 00 I 3781 I Pxoctfts t a) lot fir> t) foaa detect«d a) O.fl» + or - O.It "9/1 <»«t »t) t\| ratra dettcttl I I •] Bales I tt feules I I Froi a vr«ap of 61 I forensic ndical aiaalaatiooa, Japan. I galas, aeaa ao« 40.6 it. Feiales, r ie»» aqa 37.* ri. I l ntci niKiiTs: motszssi jititi t IXCBIlffl; tlSEHC: CIO HOB; CO HIT; I CB1CII7B; COPPIB: IBOB; BIBCOBT: I xitm: !nairsim; aimaisx; IIItBOIt! XUDlUSi iituim: TiuoiOB; znc: I GC1D; 5BOS1BIJ LITBBj HDBIIS; fllCBtlS; Slim; LOfSS; aCITa: IttUS: CCIFIMT1TE HILTHIICSS; SIX; icinsic -I- I I Takaira, a. I SazaU-Tasasato, a. I laaao, s. I T-eral, B. , \| 130 I IreklTes of I tmlton»eBt»l aealtb I 3S(1):3i-« I I I I 3782 faaeta •.1-28.0 ng/g «at at I I CottoH lq«« 5«-7« jr. I JIPH; allFOSE TlSSUt; iOlll; SO»I \| Bl«10»: 8X1II; Cl»tE!L10B; C1BSBBOR: I i TOUTS: LUn: LUKGE-. nasciis; I tnci»i; ssi»: CBEOBTUR: cafizi: I EllalS; tUC; HOTS1SIU. tlaltS; 11B»1»TI01; CCCDfUIQIal. B1ZUIS; ItPOSOTt I fjodo, I. 1 5«otl, S. I rnrnra, >. I itesblztta. X. I 1980 I Iitatnitioul I of Oceopatioaal «a6 I tBTltoiaaettl Haaltb \ »-.1»1-«0 I I „» ------- Ctroalaa 7««fl-»7-J Cr Itl 51.996, IP TWO C. BP 262 C, TP 1 •• Hg at 1«1< C. 10 •• Bg at 180 C (com mot TISSUE 3783 Tkazyax 37«» Stla 3785 Svleea 3786 He In* EIPOSalB BOOtE Inhalation 1IUTTXCU. nnoD us us u us nun or cisss I i ) 1 a) i b) i a) 9 b\| « 22 BUGE • ) lot gi»n b) let given a) lot gi«en b) lot gii«n a) lone detected b) lone detected a) lot siren b) lot gl»en C) l«t gl«B IUI a) 96.7 ag/g b) 27.9 ig/g let »t a) 104 14/9 b) 14,3 ag/ Ret «t a) Ion detected b\| lone detected. a) S. 3 » or - 3.7 nq/g cceatinln* b\| 33.3 * or - 6.9 uq/g cr«atl«ioe c) 2«.S * or - 12.5 m/g creatliioe GIIII1L MFOB11IIOI a) vorkec t) Controls Japaivae vetker, 65 yr old, at chxout* ccodncing plant Cor 30 Tr. tied of lailllary aid long cancer. Ccntrols, agio: 59-78 rr. JIPII; aDIPOSE TISSUE; lOitl; 1CIS I1BIOI; Stilt; cntlELlQI; CHIIlraa; (loins: tTTEB: Liiss: Bosciis; tllCBtlS; SKII; CBtOBIUll; CCCPE1: eitllS; CIIC; XIB1STBIU BIIBTS: iiiiUTici; cccnpiTiom BICIBDS; tcrotMioi IIPOSHBB a) lotket b\| Coatrela 3atn«3e «or)wc. K it old. at c trout tEotaeing plant for 30 jr. tied of •aiillacy knd Ing cancer. central!, aged 59-78 fr old. J1CII; aDIFOSE TISSUE; 10STI; BOHE H1B80I; JE1I1; CEBIBELLUl; CIBEEBIH; HOIITS; IlftB; LDieS; BOSCLIS; E1ICIM3; SHI; CBtOBIOB; CCEPII: Buns: site; inosniu, PIMTS; iiBjiaTioi; cccopiTioiai aisiivs; ECPOUTIOI 1TPOSOBS a) tal«a t\ r»i«s fro i a groaf of 61 aitopaiea. forensic aadlcal eiaalnatioiu, Japan. Bales, neea age «0.6 TC. r«aalea. aeaa aq 37. • TC. ItlCI !LEBE«1S; tOTOPSIES; OtPtI; II.OMOTS; IBsmc; CUHint; COBUT; cciesni; CCFPEI: iao»; BssctRt: lltlOE; SIOIISIDB; aafGtIISt; 1IBIDI»; 1ITIBOIT; SCMDlnB; siLnii: TIIUTJH: miDinB: Jl«t: e»D; BMBIBE; 1ITEB; HDI1TS; CIEEBlm; CttlBELLia: IU1T: SOSCIBS; ciicstts; sptisi; ines; losu; B1T11S; COHPU1TITE ETtLOlTICIS: SIX: PCBEISIC RltlCtlE a) Stalalees steel veldvcs, ctposed «.« 11 b) lrao«c«4 steel welders, exposed 1.0 11 c) Carolina platers, exposed 8.9 yr Italians, lean age 40 yr, taak •aiafactnrlng Increase la teta-qlecuronlftasa. Ttatelnarea, and lysoxyaarla. 1HII; IDOITS; KIDIET DISE1SIS; Dim; BIOKCTHDIATIOI ; THUS; IIDTOTBUI PCILUTIOI; IHODSTBIIL IIEICII!; eiROMTtfll: BET11S tEFEBZICB ByolO. t. Soi»ki, S. Fanya, B. Beshtxata. E. HSU latecnatloaal trchlves of Occupational and Eavlcoaicatal Bern It k •6:11-150 Byodo, E. S«akl, S. Fnrgya, B. B«shlmka. K. 1180 International Irchires of Oceapatlanal and EBTlronsaatal Baalth 46:141-150 Takava, S. Sui»ki-Ia»naot.o, S. llano, K. Teral. B. 1980 IrcbLies of Enriroiiantal Health 35(1):3«-4« flattl, i. Caratorta, 1. Pedronl. c. EOTgfci, a. elaroll. c. Pranchini, I. 1979 International archives of Ocevpatloaal and Enlronwntal Bealtk 13:123-133 (MIT P»SB) oo ------- Ctroslia 7»a.O-a7-3 Ci Itl 51.996. «P 1999 C. BP 2C2 C. TP 1 aa Hg «t 1616 C. 10 mm Ij at 180 C (COETIEOED) 1ISSBI 3787 vrlae BIPOSBBB BOOTS aiunxcu BETBOO EUBBZX or casss I»6B IEIB GEIEB1L IEFOIIHIOB levin. Protleas in risk analysis of caacec la 11 and Cr iadastry are (reseated. Varloas coapoeiids' axe cited wkicb CMS* caiccr in practical «ipomr« iti«tioas. Ifc« o««d for tea cealstcitloa 1* •apkaalzei. icivii; ciiciioms; BLOOD raisii: «EII!; IIBISItlal BT6IBBE; IBTln: CEIOnnii IIU1S; IICCZL; C1BCIIOO!»; iioosTBiii iisosentsist IWCOSTBIES; cccoriTtoiii Blums: IEOPIISBS BIFBBSBCB Beca«t!i. T. 1980 Joarul of Tozicolagr and BaTlroaaeatal Health «(S/C\|: 12 W-1227 CbZT«Otll« (8 CI) (TIB) ctrfMtlle r>»aq3(S12o9j l (9 ci) 1JOO1-29-5 B10-09-312.3Sq II 282 f TIS5VB 1 1 I 370ft I £u? I \| 1 3789 1 tmmq f EIPOSOU BOOtE 1 l 1 I \| i i iBiimcu SETBOO E9 KB \| BVBBIK I OP C1SSS 1 1 * SIB6B a) 5.8ll« (I* 7\| -l.'xtO (18) fltwn/9 t>) 1.0z10{Z»8)-2.7z10(Z<-8) fllwn/9 Dry rt lot glrea SB1B a) 1.071 10(18) flbara/f b) 1.6l10(I»8) elbers/g Dry "t 10 fiber* or farraginous bodleo/saiple GEIIFaL I»FOBS»TIC» \| EEVEBEBCE 1 « a) analyzed at Oni»«r«ity of Cardiff 1 Sebastian, p. b) lulynd ty laboratory la Paris I Billon. H.a. Faraachyaa fioa ease of plcoral I Janson, X. nsotkelloaa I Bocaaad, G. tata also for aspklbolc flbecs. \| Bigaon, J. 1 1978 10ISS; ISB1SIOS; notUSXSi 1 irehlvca des Baladles CCRPII1TITE ETUOaTIOBS; BE1S01EBIBT I Professiona«lles, de BI1BOBS: FBI KB \| (tadldi* da Trarail et 1 de Secnrlte sod ale 1 (Carls) 3 9 («-5): 229-28 1 1 1C sa spies. la Tiro notification I Jattrand, B.C. ladlcatal by lacrftase la Sl/Bv ratio, I Goal, J. s bodies. 1 Jeanrot. I. 1 Sebastian, p. tatieats. Prance \| Bignon, J. 1 1976 SAIC: tnes: IB TITBO »«11ISIS; IB 1 Sevne rraccalse des ITO HllTSIS; 15BESTOS; FIBERS \| Baladles Besplratolres 1 «. Stppleaeat 2:111-120 1 oo ------- Cobalt tc Itl sa.9332. n 193 C, tt 1100 C, TP 1 M 14 at 1910 C TXSSfg 37M loct m, Blood, Mtai 3791 Seala EEMSBEI toiTi iHiiTicii BETBOD n US" u Erases OF C1SES a) 2SO b) 260 I1KE •one detected a) lot applicable b) lot elves a) lone detected b) Cone detected e) lone detected d) toae detected fttn RE1I \| GEIIBtl IIFOKIlTIOf j tone detected 1 (alea 1 1 ftoa a groat of «1 aatopsiec. 1 fetealc aedlcal exanlnatiOBB, Japta. I Btles, aaaa age «0. S Tr. F«aal«, 1 taaa aae 37. < it. 1 I T1ICI SLEBEBlSt VITOFSIE5; J1P1I; I altBiira: usnic: CIOBIUB: COBU.I: I cncBioi; cctpnj IBOI; gncrai; 1 1ICHH; iriSKSIOB: BlIStltSE; 1 lanom: iniiont SOIOIOB: 1 SHEnn; nutim; TIBIBIOB; »K; 1 Ctlt: B»O«IH: LTTSB; KIDIEtSt I ciimm; cnzBEUAi; BEAST; atiscLis; 1 flBCBEtS; SElIEEj IOIGS; »OH»! 1 1HILJ; COfltUKln nUBMXOIS; SSS; 1 fCBEBSIC BICICIM 1 a) lot detected I a) Kaaaaa City. (3. katl-vater area b) 0.1«« * oc - 0.026 \| b) Kaasaa City. 10. aoft-aater area •9/1 I IlqaiflcaatlT blgber Krel [P -- i a) Hone detected 1 a) Bales, eacabcat, 7 sablecti b) lone tetectad \| 1) Teaalen, cetebcaa, » aablecta O >one detected I c) Balea, ctraballai, » satjecta d) lone detected 1 d] Fcaales, caraballaa, « »ab1act» 1 1 f coa a qtott of 61 aatopnlea. 1 taceaaic aedical axanlnatioaa, Japan. 1 Bales, aea* aqe 0.6 it. Fanalw, 1 leaa aoe 3?. rr. 1 1 itaCE nERtttsj inofSiES; JiPii; 1 iivniit; iisniCi CIPBIOB: COBUT: < C1ICBIJB: COfPEI] IBOf; BEICII3T: I I»ITIB: BieiunBi BaieiiKii 1 siiBiivaj tiuiiga; nnoiWi zi«c: i sctD; swam; irrstj nonis; I CllEBBVl; CIIEBEU.ni. EEaBt; IVSCLES; 1 viBCTiu; SPUSE: attest town: \| BtTllS; COBPU1TITE ETIUlTICHi $!X; I FCBEVSIC HItlCIII 1 r PISE) nri BZECS Takan, B. Snialti-IaBtaoto, B. aaano, E. fatal. B. WO lech Ires of EBTiEoiMBtal Health 35(1):3t-o Uecanbaaa, B.I. DUB. J. Irnold, J. M75 lancet 1(W1»):1008-101« Takava, I. SazaU-Ianaoto, B. leaao. K. Teral, 1. 19BO IrchlTaa of loTlroanantal Health 35 (1) • M~a4 t 00 ------- Ccb.lt 7MO-W-S Cc l« 58.9332. » l«»3 C, BP 3100 C, ?P 1 •• Rg at W10 C xi5soz 3793 Hir 379« laic 1 8IPOSDEE BOOTI IIU.TTXCIL nasn I 11101 RHR BITHOD OF C1SES US a) 31 b\| 22 a) lot given a) 0, 16 ppn b) lot given b) 0.23 ppn 1 1 I ( 1 GFIZI1L IIPOlaiTIOR a) learning disabled I) controls tl grade stndenta in Cagnda. cucioa; B »e SKIDS: POTISSIUH: SCUM; C1IBIDH; COBilT; COPPBH; ZECV: LSir; HIVGJSESZ: zzic; CEBOinti: tiiertu; SJBCOBIT: RZTIU; B!IB: CBJLCBM; cinot fieriev 24 representative Ece~analrsis treetseats are tatnlated. the feasibility of a holistic, no-nash policr foz hair analrsis is outlined and snpported. ftTIFI; IEICI B1H JITS; III]; losmtii; ausoiSREtt SMBODS: \| 1 MMIS: PBOlSIRSs COftFlBlTITE \| I \| I \| t 1 1 t 1 379S \| \| Sail t 1 I \| 1 i I \| • i 1 1 I \| • i • * 1 1 1 I IfllDlTIOVS; ILOHmil; 1RTIROVT: 1ISZ1IC; BIBIOS; BBOSISB; C1MITC: cuciVR; cncsiRC: CJSOKORJ COIIIT? ccppfB: cmittr; siBBinoa.- soie; xcoiit: IBC«: LinsMus: me; MCHSIOH: austiisi: BSBCOBT: (CITEBHDR; IICKZI: PHOSEBOBUS; ECIISSI3I!: BOBIBIOS; SElniOB; I silica: si i TIE: SOOIOR: SIBCITIOR: I stiFDi; in; Tninra: Ta«ssTi»; 1 IJIC; tlBCCIIOT i I 1 teie« of norld litecatare on the 1 eceninlntion and nloconcentcation of 1 selected toiic trace netals in nnnan 1 talr and nails tl other nannnlian 1 tnir, f»r, nails, class sad boofs. 1 tstnlsted ti qeoocapklc ar««. I tubltcts, sei, toe. exposnce I otadient, analrses in ppn. and I svtkoritr ttam orer 00 referanees. 1 1 iFtici: i0siiu.ii: ciiioii CMTBU \| MUICl; ZtllCPC: HDDt! E1ST; IN \| iZlUID; SOUTH IRZEIOL; SOOIBE1ST i is»: Hint niGBOR: OTITIB STITES; 1 RIII: mis; terisw; tiriaofi; 1 iistfic; BO!o«; cioaioii: cfreeflimi; \| CCB1U; COPP1B; LEID; BIBCDBI: I lICKZt; SZ1ZIIDR; Til: TlIlDlnii lie \| ECHUTIOf; HUH POPBHTIOS; I eioicmraiiioii BioiiBictToss: ti»D 1 foiinTioi: PCOTiitici sxposffHE; »irrs \| fCUCTIOI; niCt SLKHTS: RR11S 1. BIPZBEBCB Plbl, B.C. parkes, 9. 1977 1991313) :204-20« Chlttleboroogti. e. I960 Science of the Total iDl-iroosant 14:53-75 I f enltins, D.«. 179 Pl-SOa/4-79-049. 19 P- (IEXT PiO!) ------- Cebalt 7MO-9~« CC It! 58.9332. OP 1«93 C. BP 3100 C, TP 1 » Tig at 1910 C KOITIITOD) TISSUE 3T9S Be art 3797 Kidney 3199 Kldftef XPOSDBS BOBT1 iiimicit RET BOD Bl n „ IDBCEI OF C1SSS 1 B b) a) 19 b) 2 a) 8 M 9 C\| 12 11 KI ) < or - 0.07 ag/q (wet t\| ) lone detected a) < or » 0.11 Ufl/9 (vet »t) b) < or * O.oa ag/9 (vet •t) a) 0.00050-0.015 ag/q t] 0.0007-0.032 ng/g c) 0.0005-0.0066 09/1 vet vt BE»I I 0.01 » or - 0.03 g/g \|vet »t) ) Rone detected a.) 0.01 * or - 0.03 uq/9 (tret vt) b) 0.02 * or - 0.03 uq/q (vet vt\| a) O.OOtO nq/q D) 0.001 nq/q c) 0.0020 tq/q let vt leiians GEIZIU IIFOBIHIO a] Bales t) rcules Froi a group of 1 avtopaies. !oceasic aedical examinations, Japan. Kales, a«an aoe »O.S jr. leaales. nan aoe 37. • jr. Kl« rLEBIIlS- WOKIZS- MPII- lIIflllDI; 1BSEBTC: CIDHIDH; COBUT; CHORnn; ccena; iwn; sitcnaT; IBDIHB; BlGIESIdl; ailOHESI; tuEinna: imaoiT: scuoina: EilEiins; Timms: MIIDIOS; zuc; GCIO: BBOBIII: LITEH; KZDIETSi CHIBBOB; CEJEBEIMB: HEiBT; igSCLES; IIICBE1S; SPIIEl; 1VBSS; 10111; BmiS; CCSP«B1TI»B E»»LtHII01S; Sir; ECBIISIC REBICII1 a) Rales t) resales Pcoa a qrcnp of 61 avtopsies. forensic edieal esaainatlOBS. 3apan. laics, lean aqe 0. 6 jt. Fenales, actn aqe 31. TT. IBtCt dEBEITS; 1HTOPSIZS; JIP1M; itOBims: iBsiHic; CIDHIOH; COBILT; cEBcaiia: cciptB; IBOB: BSBCOUT; HDIBB; 9IGI1SIDB: RllGinSS; SqEIOIIB; HTIBOII-. SCaSBUlB; £ii»ii»: TiTUioi: TisiDioa; ziic; GCL1; BROHIIt; LITIE; KIDIXTS; ClBtlBM; CltmnLOR: BIltT; BOSC1ES; EIICBI1S: SPLEEI; IDKGS; lOBIi; RITUS; COBPULTITE HHOITICHS; 5EI; fCBIBSIC MtlCIBE a) Coitcols t) locket qccap I c) forkec qcoap II Kceasei caftnerr and saeltec •cikera. ages 55-76 yr, exposed to lea»r tetalg (-3 decades, live tetwen cetlieient and Aeatb 0-1. 5 yr in qroap I and 2-19 yr, qroip II. Ccatrols. aqei »3-T2 yr, «bo lived SO 111 fcoe the factory. Svedea. EIIDH: ClEirtSS; EIDIBTS; HfES; tCIGSi COBPJEIIIVE EtlLUlTIOlS; IIDOSlKlll BTGIEIZ; RilSOBEKnT atlBODS; 41TIBOII: IBSEIIC; ClDSIiJI; CI5HJB; cBBcnnB: COBILT; COEPII; eciD; IBCI: iiBTBiioa; isiB; IIDGMZSI: 1ISCOBT; f-OITBDIIDB; iscspHoaas: EoaiBiffB: SCEBDIOB; stiEnnt; SIITEBJ TIB; TniesiEi; me: mini BiziBDS; IIDOSIBIII Il»«TS; SBJITEBS; TEILtlSIOB EEFEBSiCl lakava. a. Suaki-Tasoaoto. B. IsanOr K. Ter«i, a. 1980 Archives of EaTiroaseatal Health 35(1):36-»« Takava, a. SuinM-Iasttaoto, a. tsano, K. Terai. a. 1980 Irchlres of EnTiconiental aealth 35(1):3«-4W Brane, D. Hocdberqj G. Jester, P.O. 1980 Science of the total Envlroasent 16:13-35 CIEIT P16E) oo vo ------- Cctwlt Ce ItB 59,9332, IP t«» C. St 3190 C. It 1 » Ba it 1910 C IISSII 379» llier 3800 liwr • I I 1 1 t 1 1 1 1 f I t 3801 i 1 1 • I 1 ZlfOSIM touts tiumcu SCTBOD n I I I I l i i t 11 t f l I 1 t nsiSt I1BGZ BZII 1 SZlIBll IITOM1TIOB I KSKBgBCB OF CaSZS \| \| < 1 1 1 •) 7 aj 0.02-0.10 m-j/i (wet a) 0.06 * or - 0.03 1 «l Bales \| taken, a. b) 7 rt) ag/-e (»et »t) \| l\| fviales \| samU-Iameoto. B. b) < or • 0.09 09/9 <••* W 0.05 « or - 0.03 1 1 i«eo, I. vt) 9/9 ('ot vt) I Fcov a 9rovp of 61 aBtopsles. i Tecal V \| fctensic cedlcal «ai>atioiis, Jap«o. r H8» 1 e«l«s. ie«a age »0.6 IT. rciales, t Ircilrec of 1 •••» •«• JT-' tr. \| I«Tirouutal Bealta 1 { 3S(1):3«-«4 I TItCB ZIHZBTS; ISTOPSIJS; JJP»«; I a\| 8 \|l) 0.00050-0.15 nq/q ) 9 \| b) 0.001 t-«.0l 09/9 1 11 \|c) 0.0030-0.030 19/4 1 let rt 1 i IIOBIOTS; isszBiCi cwsros: COBU.T: l I cficmm; coprzi; IBOB; BBBCOBI; i \| IttllB; B1GIISUS; IIBCaBZSBi \| \| B«t tOIBS ! aKIBOBTi SCIIBlOfl; ( l snnin: miftonj TIBUIOB; z»c: i l ««o: BtoBifE: HTM; XIDBZTS; i \| CIIIBBO!: CZIZBBUOB; BEaBI; BBSCltS; \| l tucmsi SPIBSI : IHKS: »cin: i \| SITUS; COIMB1TITE BTUU1IOBS; S»; \| \| IO11ISIC tlDICIHE \| < 1 1 1 a) 0.013 ao/g I aj Coitcols I Brtiae, o. b) 0.012 19/9 I t) lorker grcup I I lordberg, 0. e) 0.0095 ng/g I c\| lorter qregp II I tester, P.O. let it t 1 1980 .lediaii 1 Ceceased rf inerr and nelter I Science of the Total I «ortet«, ?ei 55-74 rr, expowd to \| Enrlroniait 16:13-35 1 tea?r tetali 1-3 decides: Tin 1 I teteeei ceUteieit and Jeatfc 0-1.5 yr I < ir group I »d 2-19 Tt, acovp II. I \| CdtcoK, a9< 43-72 ft, vho llwd 50 I 1 ki froi tie factory. Sweden. I 1 1 I SfZXZB; ctlatns; riOBns; IITIB; 1 IOICS: COWaUTITE tt»101TIOIS: I I IBDgSttllL BTfilEBS; (USBBEIZBT I \| \| MTBODS; IRIBOIT; USHXC; C19BIII; I \| \| C1SIBB; COMMITS: CCMIU COtttH: 1 f \| GCID: 1MB: 1MTBK0B; 1X1D; 1 I I \| tllUHSf; BHCOBT; BOITBBZiM: I \| \| I fEOSPHOlirS; SBSIBIOB: SCKDim; 1 l i i siicnm: SIITZR: TIB; TsmssTH: i 1 1 I u 1 1 a) B b\| 9 a 11 a) 0.0000-0.013 H9/9 b) 0.00050-0.04 9/9 C) 0.0020-0.00 Of/9 »«t M ZZIC: 8Z11T8 B1II1DS: IBOIStEril 1 [tins; smtzzsi tumim i i O 0.0016 oj/g ) Coatrol 1 Briue, O. b) 0.0075 a?/9 t\| Vorkec qtcap I l (ordberg, a. c) O.OOSS ag/g c) forker gtcap II I tester, ?.o. let rt 1 1980 tediana teceased refinery aid saelter 1 Science of the Total lockers, ages 55-74 rr, el posed to I ZgYironient 16:13-35 k«IVT netall 1-3 decades, tile 1 tcteeea cetlreient and deatt 0-1.5 yc 1 It oroip I aid 2-19 Tr, groac II. I cotrols. ages tt-72 rr, «ho llwd SO 1 ki Iron the factorr. Sveden. 1 sstDBi: catiTzts; cioirrs: IITES; i toias; comiiTin mioitiois: i IRRODS: UTIBOIIj'lBSIBIC; C1DU1I1: I cisioB: cBiontiB: COBILT; COFPIB; i GOtC; IIOK; IIRBIIOB; Lilt); \| iiiemsi; BIBCTBI-. •otTBDima: l ttOSfWIIIS; IVBIDIDB; SCDDIIB: t StlNIOB; SltTEt; Til: THIGSTZB; I IIIC-, BUI7B BalllVS; IBDISTBIU I n ins : snintts; ttiiasian i i (1«M fist) ------- Ccbllt Cc ItV 58.9332. IP 193 C, BP 3100 C. IT 1 m By at 1910 C (COrtllOED) 1ISSBI 302 Risele 3803 111 380* Pancrea* xposm som 1B1ITTIC11 BIT BOD IL n n BIIBBES or cms ) « b) 4 a) 9 b) 11 at « b) 3 I1KI ) lone detected ) < or - 0.13 17/9 (net t\| a) got given b) tat 9li«« a) Bom detected b) Bone detected 1MB \| GZIZS1L IBPOIBHIOB 1 1 1 ) loaa detected 1 •) Bales ) 0.04 * or - 0.06 1 t) Pennies aa/« (net ntl 1 I fro* a qrovp of (1 antopsies, \| forensic nedical exaainations, Japan. j Bales, aeu aoe 40.C jt. Teialas, 1 tea* aoa 31.* yr. I II1CZ niBIBIS; 1DTOESI1S; JUaB; \| IltlBTBin; IBSEIIC; ClBBlnB; COBILT; \| CIBCnvB; CCEPIB: 1MB; HI1COBI; \| lltrog; SlSHSIOfl; BllGlBBSE; \| IOEIBIOI1; 1B1IROBT; SCIIDIUS; 1 itiEBivi: tziuioi: TiiiDios: zinc: \| CCLD: BBOIIBI: LITtI: HDBITS; \| CIIHBDB; CHEBStlOB; BUST; BUSCltS; I I11CIE1S; SHISBi IOBGS: 10ITA; \| BIIUS: CORPM4TITS BTUOltlOIS: SSI; 1 tctnsic IICICIRI 1. - a) 0. 07 * oc - 0.04 I •> Bonn ppa 1 bl Ba b) 0.0 • or - 0.03 I l«ft thnib ppa \| Ilia r«Ti«««d: knova lava 19 ot 30 Dry »t I ct« alaaaati 1 I Baaltay 20-«0 ft olds \| ItClTS; SBT; Hits; BBTIXf; H.HBIIOH; \| IITIBOII; MSSBIC; BiSIOB; CtDHtM; 1 ciiciui; cisiOB; CHSOSIBB; COBIIT: 1 ccppn: GZBitiTiB: GOLD; IBOI: IEID; i msiisina: uBeiBssi; BMCOBT: \| tOlIBBJIOB; BICKIl; POTlSSIOa; \| iOSIDIUB; SZUBIQ9; SH.ICOI; SIITSI; \| SOCIdl: STBQBIIOB; Til; TIlinnB; 1 IIHDIHH: XIBC: iraccsiUB i a) loa« datacted I at Bales b) IOM detected I t) feiale 1 tio* • groin of «1 aitopaiea, j focansic aedical e»iimtioic( Japan. I * ------- Cctalt Co Its 58.9332, BP 1(93 C, BP 3100 C, TP 1 •• Hg at 1910 C (CORIItrXD) Tissnj 3805 Spleen 1 SXPOSOBB tomi 1 1 BET BOO M OF CASES a) 7 b) • MICE a) < or » 0.05 04/0 (vet vt) b) Bone detected BEai a\| 0.01 t or - 0.02 <>9/g (vet vt) b) Hone detected 6EIEBIL IEFOBB1TIOE a) Ralu t) Penales Iron a groep of I aatopsies. forensic eedlcal examinations, Japan. Bales, wan age so. 6 yr. Fenales, •can age 37. rr. IMCE nsiiEis: inopsiES; JIPIR; HiBinri; issERic: CIOBIDB: COBILT; CBBOnlffSj CCFPEBi IBOB; BBECOBT; ECBIPlil; alTIIOIt; SClBDXDBj SUEEH3; Tiinioi: TIUDIDI: znc; SCID; BBOBIV!; LITEB; KIDREIS; CIBEBBBB; CEBEBEUDB; BEJIBI; RDSCIBS; FJICBI1S; SP»tKi IUKS; lOETa; BRais: CCIPIBITITE Efimnios: ssi: tCBEISIC BEriCIRE BEFEEEECI Talwva, i. ftaano, C. Terai, K. 1980 archives of Environmental Health 35(1):36-M Ccpper 7<«0-5»-8 tt« 63.S«6. BP 1083 C, BP 2S»5 C. TP 1 u Eg at 1«28 C. 10 mm t.g at 18TO C \| TISS0E \| EXPOSDtE BODTE \| alllTTICIL ( BDBBIB 1 URGE i BE1E 1 GEIEMt IIMBB1TIOI \| \| HETBOB OF C1SBS \| 1 { II II II 1 1 I 3806 I US a) t a) lot 9! Ten 1 a) 0.38 07/9 vet vt I a) lorker Idrenal \| b) S b) 1.12-2.39 ag/g vet vt I b) Rot glren t) controls glani I 1 1 I Japanese vortec. 65 re old, at 1 j etiolate FCOdociaq plant foe 30 jr. f 1 1 f tied of •axillary aod lung cancer. II j \| Ccatrols, ^9-78 jr old. 1 i 1 ill I JIFU; JDIPOEB TISSUE: IOBIA; SORE III! I Bltaoi; BEJII; CfBEaEllVH; CZSEEBHII; III 1 Kllins; IlfTB; LtTRCS; EUSCLES; III I EiiCBEis; sin; cnonuB; COFFEE: I 1 1 i 3807 1 1 1* 2 lorta 1 1 t 1 ' 1 < or * 2.1 ag/g (vet vt) 1.2 + or - 1.7 ug/g (vet vtj EIT1LS; !I«C; IIDOSIBUL PtlHTS; IIMIaTIOl; CCCDPITIOI1L B1ZJS3S: tcenttTioi tmsniE tales Fro • a grogc of 61 aatopsies. foreosic aedical exallDfttiansr Japan. Blles^ eean age 40.6 rr. Peiales, ••an aqe 37.* Tr. 1I1CZ EHHITS; aUTOPSISS: JlFtl; IICBIKD1; ISSEEIC; CIDami; COBUT; cBEcsrns: CCPPEB: IBOI: IEBCHBT; IlttVI: B16IESHB; BlIClRISt; EDilDIDS; HIIHOIT: SCIVOIOB: SIIEHDI; TIIIEIOI; HMDID5! ZIIC; «C1D; aiOPIIII; UTEB; KIDR'TS; CHZB839: CZEEBELLItB: BIIET; BUSCLES; tllCBtlS; SPIEEI; LUGS; 10BI1; iniLS: COIP1UTITE ITflOaTIOIS: S!I; TCIIKSIC HIC1CIIS BZFEB3ECE Fjodo, I. SazoW. s. Fnrnya, H. Beshizaka, K. 1»BO International archives of Occupational and Environmental Bealtb •6:1«1-1SO Tnkava, S. Snzoki-Tasuaoto, g. Inano, S. Terai, B. 1980 Irckires of EnTicoDaentsl Health 35(1):36-4« (HIT PIG!) VO ro ------- per 0-50-8 • 63.516, IP 1083 C, BP 2595 C. TP 1 » Bg at 1628 C, 10 an Bg at 1870 C (COITIIVZD) T.ISSI! 3808 aorta 3809 Blood, semn 3810 Blood. sersa 3811 Blood. ceres IPOSOBE BOOT! Ingestion Ingestion Murricti BF/TBOD US BOBBEB OF C»SBS ) 1 1 5 28 2 B1TCS E1B 1 01 II Ml I1FOB81TIOB \| 1- 1 lot given a\| 1.01 ag/g vet »t I a) lorker 0.56-1, »3 ug/g set t b) lot given 1 M controls 1 I Japanese nortec, S5 vr old. at j chreeate crodncing plant for 30 yr. 1 tied of saiillart and lung cancer. 1 Controls, 59-71 it old. 1 1 Jifai: iDiposE TISSUE: IOBI; BOBB \| BlBtOB; IB ill; CIBEBKLIOT; CZBEiBOB; ) K1B1IYS; 1ITES: LSBSS: HHSCIES; a) lot give t) lot given c) lot given d) lot given a) lot given b) (ot given c) lot given d) lot given e) lot given f) lot givei g) lot given I MicBtis: SHI; cHBosioa: cansii 1 (IT IIS; me; I1DUSI3IU. PUBTS; \| 1IB1LITIO"; CCCBPITIOIIL BallBDS; \| tCiaUIIOB I1POSOBB 1 1 a) 166.6 t or - 7.95 1 a) 18 pellagiins a 11 no old. hospital day 1* f) 108 ag/dl I ft 11 no old, hospital dav 17 g) 105 ag/dl \| g) 11 no old, hospital dav S 1 Cn adnisslon levels belov detection. 1 then given 3.5 eg/dav I Ccpper-deficieint children. 1 1 C1SE BISTOBIIS; CHIIDSB"; XISBtSES; t B1IB; COP?IB: BBIILS: 2HC 1 1 1 levlev. Profile of healthy snblects 1 lastline data for deternining change I it nutritional status from Industrie I fcoA proceasieg tecfcnigaes. 1 I in 2tniic: »so its: rimst KFMTS; I I100B 5!BUR; BIIB; KIOIBIS; IIT1B; 1 Bill; «£Vin; OIRS; FOODS; SOUS; 1 vlGRHIOt; CIDBTOB: COPPEB; ] BIBGIVISE; milS; TBtCE E1EBBITS; \| ZIBC 1 IBFIBBBCI lyodo, K. Sunk!, 5. FDrnva, 1. Beshiznlta, X. 1980 International archives of Occupational and Bavironiental Health a«:1»1-150 Krlshnasacaaci , K.t.V.S. 117 aserlcan Journal of Clinical Butrition 27:108-111 Bradfield, K.B. Cordano. 1. Baertl, 3. Erahae, G.6. 1980 lancet 2(8190) :3«3-3« GnthrLe, B.B. Bobinson, n.r. 1978 >e» Zealand Bedical Joornal 87(603):3-6 (BEIT P«GE\| ------- Ccppac 740-50-8 Cl It 6X56, BP 1083 C, BP 2595 C. TP 1 •• at 1628 C. 10 » 89 at 1870 C IISSIB 3812 Blood, seraa 1 \| 1 1 1 1 3813 Blood. sera a KPOSBBB BOOTS 1 1 1 \| 1ULYTIC11 BOa-BIB \| BaBGB IBal \| GBIIBIL IIPOBBaTIOB BFTBOD OF CISSS I \| 1 1 1 1 US a) 2«0 \| a) lot given a) 14.60 » or - 3.95 \| a) Kansas city, KS. hard-vater area b) 260 \| b) lot jivea ag/100 si \| t) Kaasas City. SO, (oft-vater area I b) 172.1* * or - «.7S \| Significantly kigker level in 1 ag/100 al I aoft-iater area. 1 1 1 I IS and 8O residents aatened for age 1 1 (aean ages 37 and 37.7 yr). sex, I \| lengtk of resldeao. narital and I \| econoaic statas. occipation, amber \| \| ef cklldrea, saokiag kablta. bt, it. I 1 IB kard-vat«r area, significant 1 1 increase in hypertension. ECG I I 1 abnormalities, and kypernrieeaia. 1 1 1 1 \| \| 111315; BIS5COEI; 1DO1TS; \| \| \| CatDICTlSCDXll BISE1SBS; \| \| \| BIPBBtXlSIOl; B1OOD SBBDB; \| I I CC8P1I1TIVB IValUTJOBS: C1DBIVB; I \| \| C11CIKB; CfllCBIOH; IITBIOB; I I I I1SBESID8: PB05PBOBOBS; POT1SSIOB; I 1 I soDins; MIC; BIOICCDIOIITIOB: i I t DfiiniG IIIIB i i ii I i i IIS a) 15 j a) Bot givea a) 168 » or - 38 I a) Ben, lov tlood pressure i BIPBBXICB Blerenbans, fl. 1 rielscksan. 1.1 Dnnn , J. arnold, J. 1975 lancet 1(1914)5 1008-1016 BcKenzie, J.B. 1 b) 17 \| b) sot given ag/al I e) lea. kigk blocd pressure \| 6atkrle,~ B.B. 1 c) 19 \|c) Bot givea b) 1S9 * or - 19 I c) loien. lot blood pressure \| Prior. I.a.H. d) IS 1 d) Bot givea ng/ul I d) loaea. fcigh blood presaare 1 1978 1 c) 179 « or - 30 I Subjects selected by blood pressure I laerican Journal of 1 oq/al 1 rank froa a previous study. I clinical Butrition 1 d) 172 » or - 27 I Iftlaated daily intake, 1.5 ag. 1 31:22-28 1 1 1 1 1 1 1 1 1 1 1 1 \| \| 1 1 \| 1 I 1 1 381* lagestioa 1 1 Blood, 1 saroa \| 1 1 1 1 1 1 1 1 1 38 IS lone •arrov 1 1 1 1 1 I I .... 1 ug/al \| f 1 I Fclyaesian residents of Tokelau \| 1 Islands, croided conditions, I 1 satsistence ecoaoay. Ben, aeaa age I 1 «! yr. »«an kt 167 ca, nean it 7* kg. 1 \| Icnan, sean age 46 yr, nean kt 165 j j en, lean vt 79 kg. j 1 1 I CCCPIR; ZI1C: BIOOD SBBOB; BAIB; I 1 I \| MILS; B1III; I» ZfttllD \| II II 1 II II 1 1 a) 12 I a) Bot givea 1 b) 10 1 c) « US d) 7 •) 11 f) 8 g) ' a) 7 «) 1 b) S b) Bot given c) Bot given d) Bot given e) Bot given f) lot given g) not given h) lot given a) Bot givea b) 0.32-1.07 ag/g vet it .. a) 2.8 ug/dl I a) Baseline data, at age IS or - 1 Hillnao. L.S. b) 46.4 ug/dl \| (.3 days I Bart in, 1. e) 58 ng/dl \| r) 4 vk \| ri ore. B. d) 73.6 ug/dl 1 c) 9 vk I 1981 e) 35.3 ug/dl f d) 12 vk I Journal of Pediatrics f) 40.9 gg/dl I e) Baseline data, at age 17 » or - I 98(2): 311-313 g) 54.3 ng/dl \| 7.0 days j h) 63.9 ng/dl \| f) 4 vk \| 1 9) 9 vk \| 1 «) 12 ik \| 1 Creaatare infants fed foraula I 1 ccntaining 1.67 eg/1 cu (a-d) or 0.4 1 1 ag/1 Cu le-k) \| 1 1 I nrirrs; BICCD SIBOB: COPPKB; DIETS; i \| BII1IS \| i i a) 0.82 ag/g vet vt I a) lorker I Byodo, I. b) lot given I b) Controls I Suzuki. S. 1 1 Furuya. B. 1 Japaaese uorkec, 65 yr old, at 1 Keskiznka. K. I ceronate) trcdaciag plant for 30 yr. I 1980 1 lied of nazillnry and lung cancer. 1 International ircaives 1 Ccatrols. 99-78 yr old. I of Occupational and 1 1 SnvironMBtal Health 1 Jlfll; IDIPOS! TISSDB; »OB1a; SO1B \| 46:141-150 \| B1BBOU; Btlll; CI1BBBL10B; CIBBfSOB; I \| KIIIITS; ll»n; LOIGS; BOSCIZS; \| \| (IBCBZaS: SKll: CBtoniTl: COtPIB; \| \| BI111S; HBCt 1IDDSTH1L P1HTS; I 1 iiBiiiiioi: cccumioitt BIIUDS; i 1 fCTVUTIOl IIPOSaBK I ^ \ VO ------- Ccpper 7MO-50-8 C« III «3.S«6, IP 1083 C, BP 2S95 C, TP 1 aa Sg at t628 C, 10 •• (9 at 1870 C (COITIIDSD) I tISSVZ 1 3816 Brain 3817 train 3118 Iraia 3819 Brail KFOSB8I toitl nitmcu 1ST BCD 1 US IIS us VIM EH OF C1SSS a) 8 b) * Cl 10 3 MieS ) 2.4-12 sg/g \|Mt vt) \| ».5-1» qg/g fvejt vt) I 1.7-6.5 ag/g (vet vt) I 2.3-7.2 99/9 (Mt lit) a) lot given b) lot git«« e) 2.42-4. 19 ag/g vet it a) lot given •) lot giT« a) 2.1 3-4. 6C ug/g b) 3.26-4.09 ag/g c) 2.55-4. 20 «g/g let it a) lot given b) lot gi» c) lot given d) lot given •) lot Jinn f) lot given mi i GIIIMI iiroiuTioi I i ) 6.0 » or - 4.1 I a) Bales, cexebtan. 1 subjects g/g (vet vt) \| 1) Peaales, cerebraa, 2 sabjects ) 9.3 or - 6.7 \| c) Bales, cetebellaa. 7 subjects g/g (wet vt) 1 o) Peaales. cerobellaa. 5 sebjects ) 4.3 * or - 1.S \| og/g (vet vt) 1 ftoa a groep of «1 aitopsiea, ) 5.5 » or - 2.0 \| forensic aealeal exaaliatioc. Japan. g/g (vet vt) I gales. Man age »0.6 re. Teules. 1 ««a» age 37. yr. 1 1 II1CI niaillS; aOTOPSXBS; JlPlI; 1 unniioa; Hsmc; CIDBIOB; COBUT; I cnonni: CCIPII: nci; HICOBI; I iitioa: HiGiisina; iiiGaiisi: i stsiDius-, unaoiT; SCMDIDI; 1 Eiiniai; Tiiiiioi: wiiDini; znc: 1 GCIC: BBOBJII: titiB: KIDHIS; I cntBtni; cHiBEima; BUST; ansciis; 1 I licit IS; spmi; iotas; loill: \| IRUS; COHPU1TITE ITILUITIOJS; SIX; \| ICI1ISIC SIDICIIB 1 1 a) 4.11 ug/g 1 a) Vorke>r - oarebrva (temporal) b) «.2S 09/4 1 b) locket - eerebrua (occipital) c) lot gien 1 e) S coatrcli - cer«brt» (frontal) d) S.03 ag/g I a) lortor - cerebellui e) 3.58 ag/g 1 c) Coatrol - cerebellii let vt \| 1 Jafanem voEtor. 65 ji old. at 1 caroaate Erodociog plant for 30 yr. I tiad of aazlllary aafl lang caacer. I Ccatrola, £9-78 rr old. I OKU; iBiposi TISSOI: toaii: BOIK I guioi; EJiii; cnEBnim; CZEIEBOH: 1 JICIETS; HTn; mss; ausciIS; \| CllCIltS; Sill; CBBOnOI; CCfPEB; I BRILS; IIIC; IIDISTBIal PlaRS; \| 11B>I»ICI: CCCDPUIOIIL BIZUDS; \| tOttnaHOI IIMSOBB 1 a) 3.23 ag/g I •) City reiideats. lover flacrs b) 3. SI ag/g 1 E) City residents, apper floors c) 3.50 ag/g 1 c) Sabarbs and Tillage residents let vt I l«s«tli« correlatioa (P < 0.05) Hedians I cttveea orgaaic Pb aad ca. 1 litopslea. Resideats of Copenhagen, 1 Its suburbs, and of Tillages on 1 Haland. ages 12-S« yr. 1 I CtlHHK; 10D1TS; IOTOPSIBS; CBI1DBH 1 imii IXB PCHOTIOI; 1 cicaccnioiinoi: nan IBEIS: L»D 1 CISIIIC CO»C0IDS 1 a) S25.8 or - 3«.8 I a) Slobns pallidvs. 11 sanples, niol/g \| cceffieleit ef Taciation (CT) 21. 91! b) 659. 1 * or - 2».» I b) Caadate noclens, 11 sasples. CT mol/g I 12.3* c) 7>2.< « or - 17.6 \| c) Pntaaen, 12 staples, CT 7.9Y naol/g j d) Sabstaatia nigra, C sanples, CT d) 1139.8 » or - 66.3 \| 11.2V aaol/g \| e) Cerebral cortex, 19 sanples, CT e) «95.4 * or - 22.8 I iO.1t aaol/g I f) lippoeaapas, 13 staples, CT 19.21 f) »25.1 » or - 22.7 I naol/g I Ktopsy saitlas Dry vt I SB \| CHZBIal CCBTEX; REISOBSHXIT HBTBDDS I ciiciiH; copcBB: noi: meinsi: 1 i»n: mopsxis UfSIZICB akava, 8. oiokl-Tasnaoto, B. naao, K. Terai. 8. 980 rcniTes of •Tironneatal Bealtn S(1):36-«« flyodo, K. S«aki, S. Paroya, 1. •esbizuka. K. 1980 Intematioaal IccaiTes of Occapational aad Enviroaneatal Health »6:1»1-1SO lielsen. 1. Jensen, K.I. Grandjean. P. 1971 latare 273(5671) :602-603 Goldberg, 9.3. lllen. I. 1981 Clinical Cheaistn 27 (»): 562-56* vo (IBXT ------- Ccfptr C« lt> 63. 5«6, tt 103 C. BP 259S C, tP 1 •• Hg at 1«2B C, 10 aa Eg at 1870 C flSSfff 320 tnatk 3821 Bafr 1 1 1 1 1 1 1 1 3S22 Stir 1 1 1 r i i i i 3823 flair 1 1 1 l < 1 1 1 1 1 1 1 l l t M2» Halt ZTfiOSORZ 8O9TZ UllTClClli lOBBtt BalGI HRBQD OP CaSBS laaalatlaa PIZE 1 lot linn 1 a] 8 b) 10 I 1 1 1 1 US a) 31 t »\| 22 a) lot giro b) lot gi»«n mi i CFKUL nroiBuioi i sznnicz i i i i i i 3.8 ag f t I aapl«d at rat of 1 I/air, 2-10 I Mtnlnoi, E.E. I vie aftec batalbg 4 ace v14lB9 C9d. \ D«aa«d«l«Cv G.&« 1 I Joaaaaaon T.S. I rilvaralty pljalBB a bop, Florida I Uaeaaater, J-»- 1 1 "7S 1 IIOJIDI; units; B8X1H; CilClOB: \| Inaala of occupational I cnoiIlB; CIBOKOS; COPPZ1; ItOI; \| Byglan* 1»:22S-23» I mi: Baieiiisz: ncm; POCISSIOB; i l sotroa, iirniiTB: Tiiirijni; ate-, in i 1 M1IOTJOP; TOBSS; mnsnial 1 \| 11BOSPBE11S: tBaCZ ZIEBIIS I i r 1 t a\| IS. 6 * or - 1.73 \| a) Pclla-griai \| Kr iebmaachiri . ag/g 1 t) BealtVr »Uont»ac» 1 x.l.r.H. b) 8,7 * or - O.S7 \| \| 19T« ag/g 1 todaaic pvllaoclaa, 16-60 ji old and I laerlcaa Joacaal of 1 b«altar al«« oocloccoaoalcallr 1 clinical latrition 1 uteita to rillagciaa. I 27:tO»-111 1 1 1 CCPPfl; BX111S; H1EB11 RZtlBOtlSI; ( 1 CISZISBS; HEta; BIOOS SEEDS; BITIZ; t i sui irszasis; inic icias: BUI: i 1 CCBPMI1IVI (VUDITI} t? fft l tj Cettiali I Parkw, 1. 1 1 1«7T 1 laanlaa fllaiblad utf soraal Jit «ad l scluc 1 att arad* stadant* 1* Canada. I 1»Bfa313) s20»-2O6 1 1 1 cucin; siGiJsios: wmssioB; i I SCtlOU: caDBItM; OOBILT; const; \| \| 1(0 f; IMC; MISMSSX: ZI«C; \| t i cticiTM} imttrts matt; HETIIS; i I 1 Bill; CBIUBEl: CaMDl \| 1 1 1 1 1 1 1 1 E«»i«». 24 cpnwatati» I cbittlwbocoagli, B. I \| F>^analy9ia tcvatatats arc I 1980 1 I tatolatad. tta fcaalbilltr of a I scl«ce of the Total 1 \| 1 tells tic. ao-ash policy foe oair I MTlrooaoat H:33-73 1 1 1 1 1 1 1 1 f j 1 1ST . 1 8.58-15.09 ng/g - - 1 aDalyals la cvtllacd and sapportod. \| 4 1 I fITIZI: TB1CI B1E1EBTS; Bilk; I 1 icsttiiH: ausgizBcn iRBors: i i fiins; PROIH»SJ ccipuitm i 1 ITJtmtlOIS; 1IBBTIDS; HIIBCn; I I JPSZdC; B1BIUB; BEOKK; C1IBIOB; I j c»icn ------- ccpper Co It* 63.5(6, IP 1083 C, BP 2595 C. TP 1 •« Eg at 1C28 C. 10 II Bg at 1870 C (COITIIUKD) 1I3SDI 325 lair •sane 4a«O lair 3827 Bait BIFOSms 10011 nunicu OTBCD US It HJBBSS or CISBS 3 »t ^A 1 Jo b) 2« 0 37 S) 28 a) 16 f) 19 a) 23 b) 19 c) «2 1) 11 e) 26 f) 10 11IGI ) Rot applicable ) lot applicable ) lot applicable ) lot applicable ) 11-35 ng/g ) 1«-68 04/9 ) 11-28 ag/g ) 13-39 ag/g ) 16-27 119/9 0 lot given c) lot given d) lot given e) lot given f) lot given a) «-10» ug/g b) 10-25 og/g c) 1-215 ug/g d) «-35 ag/g e) 6-»3 aj/g f) -»3 ag/g mi ) 36 «g/g ) 13 09/9 O 56 ag/g fl) 22 ag/g «) 19 or - 7 ng/g f) 29 * or - 11 ag/g g) 21 » or - 6 09/9 h) 25 • oc - 11 ag/g i) 21 * or - 3 ng/g ag/g b) 11.0 * or - 1.8 ag/g c) 10.2 « ot - 1.7 ag/g d) 28. 5 t or - 4.7 ng/g e) 31. S t or - «.« «g/g C) 20.8 t or - 7.8 ag/g a) 22 ug/g b) 59 ag/g c) 29 ng/g 1 7 ag/g e) 10 ug/g f) 9 ag/g Medians eiiiiiL iirosaaiioi ) 10 ao old patient, o& admission ) 11 >o old patient. OB adBission ) 10 BO old, recovered ) 11 BO old recovered •) 11 COBtColS f) K Kvaahicrkot patients, on adiissioi g) S I»a»hioi!tot patients, xecoveted i) 1 gatasau patiartl, 01 adnisaion .) 9 aaiaaint patients, tvconred Cepper-deficievt 10- and 11 BO olds. loraal eciticls, aad negative ccatrols with Hataaana aad liaahiottot. C1SI HISTOSIIS: CBIID5II; DISUSES: mi; COFPII; mils: zuc b) Tall-ten Ion blrtkveigkt, at blrtt c) Pce-tera, at birth d) Controls, 3 BO e) Fnll-tera lo« birtaveigbt, 3 BO f) fre-tert, 3 BO g«diaas « 01 - si leoaates in Halifax. Pre-tera gxoap lean bicthieigkt 1880 g, 26-36 t\ geatatloa, foil-ten lov birth« ------- CCppar 7M 0-50-1 Cl Itl C3.SW, I* 1083 C, BP 259S C, TP 1 aa Eg »t 1628 C. 10 » Bg at 1879 C fCOITIIllCD) IISSDS 38 28 Bait iiMsnts tons IIIIRXCIX RCTBOD •3ea OF CIS! 1 1 3B2» I rng«cion us i ai is I late t 1 b) 17 l\| C) 19 It 1 « 15 ( 1 i 1 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 .1 1 1 ......... 1 3139 U a) («rt 1 ( I 1 I t «>) 2 IIICB mi i SEiim iiroBRirio* i 1 1 rci« of rarld lltaratar os tie I accaavlatioa and bloe>acatratioa of 1 acleetad toxic tcac aatalx la bnaaii 1 atic >it nil aad oth«r aaanllaa 1 tali, foe, aiils, clara aed tools. 1 Tatalat«d JIT geographic area. 1 1 «i61«ct», MX. to. xpoar«. I \| ozadiaat, aaalra* IB ppav and I 1 attaorltr tret orcr »»0 raf«r«so««. 1 1 I \| micii IDSIUtUj C1UD1; CIIT1U I i «§i»ict: IOBCPB: u»nz nsi; in I i iiuiu: SOOIB unict; somnin i 1 Vot flTCI 1 >t «1T«> lot gl»« lot jt»«« \| < or « 4.3 «?/9 (nt •t) b) 2.<-6.9 «9/J (wt >t) I 1511; OIIIJI KII600I; DRTIO STUBS: t 1 aui; iiii5: BifiEt: imioii: i 1 1BSHIC: BOBC»; C1B5IUB; CH08IJB: 1 1 CCI11T; COPPlt: 1111; BISCUIT: \| 1 11CIF1; SB1E1IHB; til; Tllllloa; III I 1 icimioi: itiHu paraiinois; t 1 iioiccaamiioi; BIOIIDICIIOIS; HID i 1 foiiBnoi; pcromioi CTPOSOIB; »T«B i 1 (cuonoi: tuct nimis; anus i J i l i vi/q I t) ••>. klgk blocd (t<»t« I b! 10. a t 01 - «o/o \| e) IOMI, Ion blooj pr«ssut« \| c\| ID. t + or - 3.0 \| o) IOHI, klgi blood preside* j M/7 \| £otj«cts Mlacted by blood pnaxur* I 4) 14.8 • or - 2.3 I tait fro> a tnvloM atodf . I •9/9 1 Itlaat«d dallr iitaln, 1.5 ag. I 1 I j felTiaslan tasldamta of To»«lao I j Iclaida, eroidad eoidltlona, I I Mtslstoac «CODO«T. B»n, vaai aq« \| 1 «5 tr, aaan bt 167 ca. Man «t T* kg. \| 1 Icaca, Man ag« »6 ir, «ai at 16S I I em, a<» at 79 kg. I 1 1 I ccppia: sue: BIOOO SEBOS; HIIB: i l mis; »i»: IM ZBUIID ( i i BZFBBZBCI Jeakias, B.I. 1979 BPl-«00/»-79-M9, IBt pp. BcRaazla, J«R. Gitkria, B.I. Ftiox, 1. 1. 8. 1S78 laerican Journal of cHaical latrltloi 31:«J2-«28 a) 2. » » or - 1.8 I a) Balas I Tokav. a. »9/J («t »t) t\| reaalM f E J» «. 8 • or - 3.9 t 1 azafci-Iasaaoto. a. aamo. K. ng/g (»et »t) Proa a gco«i of 61 avtopclas, 1 Taral. R. fonasic aadieal vxaalaatlou, Japaa. 1 1984 Bal«s, aat age «.« yt. r«aal«s, f 1 ccnlTei of aa> a«a 37.1 rr. I EmrironMiital Baaltt 1 3! 1I1CI 1LIBIITS; HTTOPS1ES: Jlfll; t atORIIil: llSniC; CIDBIII; COB1LI; f cnoBios: CCCKI; IBOI; aiBctrar; i IltlM: llGIBIBB; UieilZSB; \| iOtlDHI; IITIIOIT; SCHBina; ( stmria; tnuiai; tiiioina: •Jisc; i GCID; B10BIII; UCTEB; KIDIBTS; I ciiEBBii: ciimiua; BUST: lasctES; i CIKBBIS; SPIUI; LUIGS: 10ST1: 1 aitus; coirumn iriivincis; ssi: i rcmsic Biticiii i i i («tii Pie i) > ------- 7MO-50-8 Ct lt» 6J.5«6. IP 1083 C. St 2595 C, TP 1 •• Bg it 1628 C. 10 •• Sg at 1870 C (COBtlHEV) HSSIt 3831 Kidney 3832 Kidney 3833 Kiaaey EIPOSOBI BOVTX iBixYTicu RTBOB u us n •0IB8B or cisss ) « ) 2 «) 1 b) 5 a) 8 b) 9 CJ 12 S1BSB J 1.5-3.8 ag/g (»«t wt) ) 1.«-3.0 og/g I 1.07-1.19 ag/g b) 0.89-3.72 «g/g C) 0.82-3.58 ag/g Bet « iui \| eiiiiti. iirosufioi I MPIBBBCB i i 1 1 a) 2.5 » or - 1.1 1 a) Bales I Takana, S. ng/g (»«t »t) 1 t) resales 1 Sazati-lasnaoto, a. b) 2.2 + or - 1.1 1 1 »»aao. «• ag/g (»et rt) 1 Hoi a groap of 61 utopsies. 1 T«rai. B. I forensic ndieal ezaaliatioas, Japan. I 1910 I Bales, Ma» ao* ao.6 yr. P«aal«s, 1 IrchlTM of 1 a«a« am 37.* jr. \ Intitouutal Malth I 1 35(1):3«-«* 1 nici niBiiis: lOTOPSixs; juai: i i iiciimB: iisnic: CIBHOH; COBU.T: i \| CIBOBTDl; COFPBB; IIOI; BIBCDBt; 1 1 IltCTB: BKHSXHB; BiIMlISI; 1 I ItHIVira; 1BIXBOBT; sciiDIOl; I 1 siimus: mum; TIKDIDB; sue; i \| CCLD; B10RIBB; 1ITB1; EIDBZ1S; 1 I ctBiBira: cntBitittB: BSiBi; anscLiS; i I FMCB113: SftESIi LOBGS: ICSTl: 1 1 iittts; coiiniTin BTiLoitiois; SET; i 1 ICBHSIC IICICIII 1 1 1 1 1 a) 1,«9 ng/g »«t vt \| a) lork«r 1 Bjodo, K. b) «ot givei \| k> Co«trola 1 Somki. S. 1 I Tncnra, S. I jaiaHi* «ott«E. «5 TE old. at 1 Beskliaka. K. I cttoaata (ceaaelag plaat foe 30 TE. 1 19SO 1 tied of •axillary aid long cucnr. 1 International irchlTos I Ceatrols, 59-78 jr old. 1 of Occapational and 1 \| iBTtCOBMatal Baalth I J»II; IDIPOSt TISSOB; IOBT1; Bon I «6:1«1-150 1 iiBim; BSIIB; CIIBBELLOB; CZBBIIOB; i 1 KIBIITS: 1ITEB; lOIGS; HUSCLIS; \| \| I1BCBB1S: SKU: CBBOnOH; CCIfSS; I \| BFtltS; ZIBC; IBOOSnilL PlllTS-. I 1 IIBIUTIOB; CCCBFlflOIU, HIZHDS; 1 I fCPOIlTIOI IIKSDBB 1 1 • 1 1 a) 1.57 «g/g \| a) coatcoli 1 Brrae, B. b) t.6« «g/g \| t) Iock«r gteap I 1 BoEdbeEg, C. ol 1.66 ng/g \| c) «ork«r qcoip It 1 s«st«r, P.O. let it 1 1 1'80 Rediaas I C«c«as«4 rofisorr and Melt.r 1 Science of the Total \| •cikacs. ag«> 55-76 TE. exposed to 1 InTitoaaent 16:13-35 I k«aT tetali 1-3 decades. Tiaa 1 1 tctveea Eetlteaeat and deata 0-1. S yr 1 1 la groip t aad 2-19 TE. groap II> 1 \| ccattola, agas »3-72 yr, »»o ll»ed 50 1 j ka fro a the factory. Svedea. 1 I jiiDii: ciBaTEBS: mo«TS: LITIB; I I miss: coMitmn iTiiniTiois; I 1 lltBSTBIll BTGIBIB; BIISUIIBIBT 1 1 (HMDS; 1RHOBT: 1BS1SIC: C1BHOB: I I CISlnfl: CBICRIDH; COB11T; COJPEB; I i «c»: HOB: itKBMW: LEID; \| t BIICIIISI; BZBCOBT: BOLTBDHOR; 1 1 IBCSPHOSOS; BDBIDIOB; SC1BDIDB; 1 \| SZ1ZII1M: SJ1TCT; TI»: THIGSTJB; \| 1 IIIC: BBIItB H121SBS; IIODSTBIll 1 \| tllBTS; SBtHEBS; miBBIUH \| 1 1 net) ------- ccpper 74.40-SC-8 Co »« 63.546, IIP 1083 C, BP 259S C, TP 1 •• Hg at 1628 C, 10 •• fg at 1870 C (CORIRBED) 1 1 1 1 1 1 1 1ISSO! BIPOSIJBZ tODlS ASAIYTICA1 B0BBZB HETHOD Of C1SI. 383 U a) 10 liver b) 3 1 I 1 1 1 1 1 3835 1 US line \ 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I 3836 line i 1 1 3837 lifer I » » f 1 1 Ingestion » 1 1 M 1 4 « «> 1 1 b) 5 1 a) 8 b) 9 c) 11 I1IGX > a) 3.9-38 09/9 <«»t vt) b) 3.0-8.2 ag/g (net vt) a) lot given b) 1.16-10.20 ug/g vet vt 1 1 a) 1.44-6.9C og/g 1 b) 1.30-5.2* ag/g c) 1.38-5.52 og/g let vt BXAI \| GZIIB1L IlfOHBlTIOl \| BSFS8ERCZ 1 1 1 1 1 1 a) 16 » or - 12 og/g I » Hales I mkava. 9. (vet vt) \| I) Females \| Snznki-Iasnioto, B. b) 5. 9 » or - 2.« 1 1 Amano, K. ng/g (vet vt} 1 From a gromp of 61 autopsies, I Terai, B. I forensic lexical examinations, Japan. I 1980 j Bales, lean age 40.6 jr. Feaales, I Archives of I lean age 37.4 vr. I Environmental Health 1 1 35(1):3«-44 \| TBACE BLIMBITS; AUTOPSIES; JJPA5; \| \| AIOsImTJg; ABSEIIC; C1DHIOH: CO BUT; \| \| CBROHIUS; COEPBB; IBO»; HBBCORI; \| 1 UDmn: aiciEsioB; uxsarxsz; i I IOEIEIII1I; 1III8OIT: SCAHDIUS; \| 1 siLEiins: iiiMios; Tinoioi: ziitc: i I SCH: BSOBIIE; LITEB; KID1XI5; \| t ClSnimi; CHEBE11UB: BK1BI; IDSCLES; 1 \| FIBCBB1S; SFIEXI; tDIGS; 1CBIJ; \| \| BIT1LS; COHFUITITZ BTltUiTJOKS; SET; I \| FGBEISIC SICICIHE I 1 1 a) 4.26 ng/g vet vt 1 <) worker 1 Sjoia. f. b) lot given 1 t) Controls I Suzuki, S. I I FuruTa, H. \| Japanese vorkec, 65 Tr old, at I Heshliola, K. I cntoeattt Fccdocing plant for 30 yr. I 1980 1 Cied of •axillary and long cancer. I International Archives I Ccatrols, S9-7A yr old. I of Occupational and I 1 EnTlronieatal Health \| JAEAI; ADIPOSE TISSUE: AOBTA: BORE I 46:141-150 I B1BBOB; EBAII; CEBEBELLBB: CEBIEBOI; 1 I KICIIIS; IITfS; LUBGS; BOSCIES; \| I fllCBEAS; SKIS; CBEOBlaH; COIPEB: I \| BETAISJ ZIIC; IBOHSTBIU PIABTS; \| I I1BAIATIOB; CCCBPSTIOKJ1 B1Z18DS; I I ECPOIiTICli UPOSOBB I 1 1 1 1 a) 3.59 ag/g 1 a) Control! 1 Brune. D. b) 2.91 ug/g I t) socket gtcap I 1 Koraberg, C. c) 3.08 ag/g 1 c) socket group II j tester, F.O. Ret vt 1 I 1980 Medians \| Ceceased refinery and saelter I Science of the Total 1 vcrkers, aqes 55-76 TT, exposed to j Environment 16:13-35 1 betvaen retirement and death 0-1. 5 rr 1 I in group I and 2-19 rr, group II. 1 1 Centrals, ages 43-72 re, vbo lived 50 1 1 ki ftoi the factory. Sveden. 1 1 1 1 SfECZB; C1DATZRS: KIDIET5; IIT5B; I \| I DIGS; COBPIBATIVB BTA1UATIOIS; \| I IIEOST8IAL BTSIEIB; HXASOXEaEMT I I BITBODS; ARIIOII; 1BS1IIC; CADBIUB: 1 I CISIOR; C BBC BIBB; COBALT: COPP1B; \| \| eCID; 1501; IllTHAHOS; LEAD; \| 1 eiiGiiist; incvBT; ROXTBDZIDI: I 1 fBCSPHOBDS; BDBIDI01: SCASDIOH: I I fHEIin.l; SIITE8; TIM; TDIGSTH: I 1 !UC: gtllTB BAZABDS: IIDOSTBI1I I 1 tl«RS; SBtllSBS; TEL10BIV1 I 1 1 1 1 1 tevlev. Profile of healthy snb-Jects. t Gnthrie, B.E. I Baseline data for determining changes I Bobinson, B.F. 1 in intritional status froi indnstrlal I 1978 1 feed processing techniques. i Rev Zealand Sedleal 1 I Journal 87(6031:3-8 1 111 ZtrLAIt; ADULTS; FITOS; HF1I7S; I 1 I1CCD SnV ------- Ccgtn 7«««-5»-» Co JMT 63.56, If 1083 C, BP 2595 C. TP 1 M Bg at 1628 C, 10 •• »g at 1870 C fCOITIXDED) nssvt 3838 long 3839 lung 380 tinq tXMSDII SOME IIU.TTICU 8ETBOD U US U IDSBEB OF CaSKS 1 2 b) 2 a) 8 M 9 c\| 11 1161 J < or » 5.2 «g/g (»et t) 1 0.9-6.2 og/g (net it) a) Bot aiTen bj 0.77-1.59 agyg c\| Bot giteo A) 0.60-1.32 0.9/9 a) lot giTst f) 0.81-1.96 aoye- Bet it a) 0.62-1.M ng/q b) 0.17-1.5 «g/o; c) 0.059-2.15 ug/g It « BUB \| ClBIBal IBYOBBaZICB 1 1 I a) 2.6 * or - l.< 1 a\| Balea g/g (vet vtj I t) Feaalca b\| 3.5 » 01 - 3.6 \| ng/g (vet »t) 1 'roa a group of it autopsies. 1 fortnslc ndical exailBatioas. Japan. j Bales, Mai age «0.6 rr. Maales. 1 ie»» aae 37.* yr- 1 \| IB 1C I CISBTBTSS iOTOPSIES; JiPlt; \| limiTln; IES1IIC; CIBBIOB; COB1LT; \| CEBCIIDB; COPPIB: 11013 HEBCOBTj I utiua; SMIESIDB: BIBSIBBSS: I iBiiDivi; IRUOII; sctmn: I sui«n»; TinBita; niioina; zinc: \| GC10: B10RIBI; LITER: KID1ETS; i ClSIBfiajj CltEBBttOB; HE1ET; BOSCIES; i EiBCBEis; spiiEi; imns; icrti: \| BITtLS; COBPU4TITE EYUOITIOBS; SEI; \| ICBE1SIC BIEICIBI i a) 0. 5S ng/g I a) Sorter, right upper lobe b) Hot gi»e \| b) 5 eoatrols. tlqht upper lobe e\| 0.96 uq/g j el Borkar, right loner lobe 4) lot qiven I 9) 5 coattol. right lover lobe e) 1.02 og/g I «l Borker. left upper lobe f) Bat give I f) 5 contrail, left upper lobe let vt \| 1 Jtpaiese "or«r, 65 re old, at 1 chroaate ftodaciim plait toe 3O 71. I Clad of aaxillarr && laaq cancer. I Ctstiols, 59-18 TT oia. I Jicii: IOIFOSE f ISSUE; aoBii: son \| SIISOW; EBIIli CUEBZL10B; ClBEtSdd; I Hums: HTiB; LDUSS; nosciES; \| ElBCBtIS: SHI: CBBOBIOT; COPPEB; \| R1T1I.S: ZIIC: UDDSIBIIL PlIBTS; \ imilTIOB; OCCieKKniL UtlSDS; \| ICfOIftTTOB ZXPOSOBS 1 a) 1.10 ag/g 1 a) coatrclc b\| 1.0* ng/g I t\| torkec grenp I c) 1.0* og/g \| c) Borker group II Bet vt 1 ledians I I«c«asad cef luerr and aaelter 1 vorkera, agea 55-7$ jt, expose! to 1 aaar aetala 1-3 decades, tile I bcteeea cetlieaent anl death 0-1.5 rr \| in group I aid 2-19 Tt, group II. j Controls, aa«a 13-72 ji, io live! 50 I ka froa the tactorr. Sveden- 1 \| JKtEB; C»D»TEES; KIDIITS; IITiBj \| IOISS; COBP1FITITE ETILD1TIOJS; \| IBDOSTSItl BTOIBBB; BEaSaiEBEBT \| SITBODSj inilOBT: 1SSEBIC; C1DBIOB; \| CISIOB; CKICUOl; COBlllj COl?ZI; \| CO 10; IBOB; I1BTB1BQIT; 1»D; i iitGiitst; stacnii: sonBriiBB; \| tBCSPROBOS: BDBIOIOR: SCaBDIOH; \| SltBHUS; 5IITEB; Tit; TOBCSTEB; \| tIBC: B!IITB B1I1BDS; IIOOSTSIU \| HUTS; SIIHEBS; lEliaBIOH 1 tEIEBBBCE Tukava, 5. Sninki-Ia«naoto, I. laaao, t. Teral, B. 1980 archives of laTlroaMBtal Health 35(1):3C-« .._ Byodo, K. Suzuki, S. Fttrwa. 1. Beshlznka; K. 1980 Interaatloaal Irchlres of Occupational and EiTlronaental Health «6:11-150 — ™ Braae, D. Bordberg, 6. Beater, P.O. 1980 Scieoce of the lota! EiTlrona«nt 16:13-35 (BEIT PtGC) ------- 7M8-SO-S c« It* 63.S«C. ST 1083 C. BP 2595 C. YP 1 M Sq at 1628 C, 10 •• 89 t 1870 C (COITIIIIED) 1 1 1 1 r i i i i i i i flSSOE EXPOSDIB BOOTS 381 Ingeatloa Bilk 1 1 1 1 1 382 1 Bssele I 1 1 1 1 1 1 1 1 I 1 1 1 1 1 1 I i 1 1 iiiiTTicu. BETBOD . la IDBBIB OF USES a) a ) e BIICE a) < or « 5.2 ag/g (vet vt) b) < or • 7.6 va/g (vet vtj 1 1111 \| SfitBll IBTOBBallOB 1 1 Serie.. profile of kealthy subjects 1 BacellM data foe deteeidnlng eaange j la latrltional states (con lidestrla 1 feed processing teckniqaes. 1 I in itutic: UDLTS; rr«s; IIFMT.S; \| FIOGD SEIffB: BUB; KIDIETS; LITEB; \| lltK; lETIil; DIRS; FOODS; SOILS: \| TIGBT1TIOI; CIO BIDS; COPPEB; f BlieilESF; IETA15; ZBaCE EIJHIBTS; \| ZIIC 1 1 a) 2.1 * oe - 2.3 I a) Hales ag/g (vet vt) 1 t) fesalas b) Z.O * oe - 2,« ) ig/g (vet vt) t (cos a groaF of Ct aatopsles. \| feceasle aadlcal ezaalnatloas, Japan. 1 Bales, neao age o.t re. resales. 1 sean age 37. » rr. 1 \| IBICt ELEiEITS; aVTOPSIES; JaPlI: 1 IICBIIOT; 1BSCTIC; CUBTOB: COBU.I: I \| CBBCBTBBs CCFPBB: I BOB; BB1CDFI; \| \| IIDIB1J aiSBISIOB; BaieilZSE; 1 \| IBCmotl; 1IIII01T; SC1BDIOB; 1 i seiBBTOS; uiaiTOB: niiDioB: ziic; 1 i i eciD: BIOBIII: IITEI; rums: 1 1 \| CMIBSOT; CEflBElLUS; BBHt; HOSCIES; 1 1 1 MICJ11S; SPIFBI; tUISS; 10IT1; I 1 1 BmtS; COBPIB1TITE STILOITIOIS; SH; 4 \| \| FC3HSIC BICICIII 1 11 f II 1 38«3 \| I US 11 lot glreo I 0.50 ng/g vet vt I 1 flu 1 1 1 1 1 1 38«« lall sole \| \| 1 1 1 1 1 1 1 1 1 1 II 1 1 \|J \| \| Japanese vorker. 65 rr old, at II 1 1 ckroaate pcooiclag plait far 30 re. \|\| \| I tied cf saxlllarj asd lung caacer. II 1 1 1 1 1 I J1FJB: 1PIPOSE TISSUE: 10BTI: BOIE \| B1BIOI; (Sail; CIBEBniVB; CEEBBSOBi I SIOBETS; tITEB: IOIS5; BQSCIIS; I E1ICIII5; Slllt CB80BTOB; COFPIB; \| BrillS; ZIIC; XIBISTBIal PI11TS; \| 1IBII1TIOI; CCCnPlTIOIal BaZUDS; i toremioi IIPOSDBE 1 1 1 1 revlev at vorld literatare ox the f accoselatton and bloeeoeeatratloa of 1 selected tezlc trace eetals la kaaan 1 late aai aails and other aaaaali&a 1 halt, fie. Balls, elavs and hoofs. 1 Iitulated by geographic area« t gcadleat. aaalrses In pps, and 1 aitborlly feea ever 100 references. 1 \| Illicit 10STBU.II; C1I1D1; CF.ITNL \| lEllICI; IOt«E; BICCll BIST: in I miiio: soon uraici; SOOTKEIST \| ISII; OiniD KHSDOB; U»ITtD STITES; \| Bill; IU1S; 1EVI3B; 1RIMIT: I nsiiic; BOici; ctDBm: cBtcHin«: \ CCS 111-, CCKll.; UkD; 5SBC11ST; I iiCKEi: sninoB: TI«: IIBIDIOH; in I CCUOIIOI; Itlaftl ffOPQLatlOIS; I lUiccuniKioi; iioiiBiciiiou; LUD 1 icturrioB-. PCPVLITIO* ETPOSOBE-. IITSC i tciintoB: TIUCI simns; BEXILS i •IFESEICE Gotkrle. B.E. Sobiason, B.F. 1»7* lev Zealand Helical Journal 87(6031:3-8 Tokava. a. Snzaxi-Tacniaoto, !l. iaano, n. Teral, B. 1980 lechlres of Fnrironnantal Be alt b 35(1):36-4» eroto, E. \| saitttl, s. \| Fnrora, 1. \| aesaizaka, 1C. 1980 International Irchires of Occopatlooal and IDTlconnental Health 4(:iai'-iso Jenklas, O.I. 1979 BPl-600/»-79-0«9, 18« PP. o NJ ------- Ccpp«r 7MO-SO-« Co Itt 63.5««. (F 1013 C, W 2595 C, TV I u B* at 162« C, 10 (a B? «t MTO C (COVT1TID9D) nssn 38« lall 3a« Faacreaa 3817 Fa«ct«a* 3048 Faaryax IPOSBBJ toBiz atLoa 1H1TTIC1I BETIOV US u us mm OF C1SXS > 15 17 19 1 « a) 5 M 2 a) 1 b) 5 a) 1 I1KE ) lot jlY«n I lot 9iT«« 1 lot give* 1 lot giT«n a) 1.4-1.9 ng/g (wet wt\| ) < or « 2.0 ag/g (wet •tj a) lot gl»«» b! 0.46-2.2? ag/g ««t «t a) lot glT«a t) 0.90-1. 16 «g/g ««t at Bill 1 15.6 t or - 1.8 g/g ) 21.9 » at - 27.9 0/9 O 23. » oi - 12.9 <»/g 1 10.4 * oc - 0.5 9/9 a) 1.7 * or - 0.2 09/9 C«t »t) b) 1.0 » or - 1-» B9/9 <"«t wt) i) 0.39 ag/g not wt b) lot glvea a) 0.80 ag/g not wt b) lot gin* t CM mi moisiTioi t) lei, low 11004 prastare b) Bea. high bloct pxesrare c) loan, low blooi pressace {) loata, high blood praasare S«b1«eta Ml«ct«a bT blood prasaura tank fcoa a trarioa* st«di- fatlaated daily latako. 1.5 19. FolrMSlaa culftaats of Tokclaa Iflaidi, erotted condltiona. ntalstamcc aconoar- Son, Ma* «g« 4! it, aaai It 17 ci, Man »t 7» kg. Bcna, Mai ago tS rr, aoan It 1«S ea, aaaa «t n kg. tepPH; me; Bioon SSBOB; BUI; nils: quit; in nuui a) Bates 1) F«al«s ftoi a groat of «1 aatoo(l«s. forniic acOlcal ozailaatloa, Japaa. Bl«a, Man ag« »0. 6 jr. r«aal«a. a«aa ago 37.4 jr. met ziMcns; inopsits: j»pn: itoiiigi; aisEBic; ciDBina: COBU.T: cnciini: cctPiB; IMIJ SEBCHBI: tlCtOC BieiKlOB; UI6UMS: BttlDiuri; iiiinoir; SCIIDIDB: stiTiivi; iiiuiint: miDioB: znc; eclt; BSOBTIl; tniB; IIDIIIS; Clllim: CIBEBE1LOBJ BEIBT; RDSCIBS: IllCtllSt SIIEII; tllSS; 10BTI; BtTUS; COIIaUTITB STliOllIOIS: S!I; FCBIISIC BEIJCIBE al lorkar b) Coatrols japana worker. 65 rr old, at chxosat* fiooaclaa plant for 30 TC* rial of aaxillarr aa4 lang cuear. ccatrot. 59-78 rr oW. Jim: IOIPOSE nssuEi toiti: sou mm; Hiii: cmaniw; cnsspon; (Ifiins; llttK; LOISS; MSCUS; fiicms; ssii; cstoaoH; COEPSH; cmiSi tile; inastiiu HMT$; iiitutioi; cccnusnii «i»»s; cctaimci ZIFOSOBB a) lorkar b) Coatrola Jacaaew werkar, 85 rr oil, at caxoaate prolaelng plant tat 30 TC. Cl<9 of aailllUT and lung ca«c«r. Ceitrols. 5S-TS rr old. J1FII: 1DIPOSB TTSSOIJ 1OBT1; BCIE Mtioi: BBIIB; CIBEBIILOIIJ CIBEBRUB: IIDIHS; UTEB; IOIS5; BOSCltS; UaCEfIS; SIM; CBROnuH: CCEPH; HIIIS; IIIC; IIDOSnilt FI1ITS! llltUTIOl; CCCOPIIIOHII. B1Z1BDS; fOfDIITIOl IIFOSVIB BHEJMCI ncKoaiie, J.a. eothrlo, B.I. ftiot, I.l.S. 197 lavrican Joans 1 of Cllalcal IntrltioB 31:422-428 Tnkawa, S. Sankl-Taoacoto. B. aaaao, x. Taul, I. 1980 archives of Eftvlxorattatal Health 35(1>:3«-44 ITOjO, K. Sazakl, S. TttTUJB.* !• Beshixvka. S. 1980 International archive* of Oceapatlooal aad EavlroBmaatal Health «t1«1-150 Hroio i Suzuki, S. I«r«ra, I. Reshixuka, C. 1980 iBtenatloaal IrehiTes of Oceapational a&d r«Tlrota«atal Health 46:141-150 (IIIT FISB) ------- ccpper 7440-SO-8 CD lt» 63.546. IP 1083 C, B 2595 C. TP 1 m» Eg at IC2« C. 10 •• H<7 at 1870 C (COfTXItTED) IISSDE txzosnn Boort AIAITTICAI i amsxt IAIGE i »g»i i GEIIKU HEOBBATIOS 3849 stin i 1 r 3850 I Spinal 1 1 [ 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 f 1 1 1 J 3851 \| 1 Spleen I 1 1 1 1 1 1 1 1 1 \| 1 3852 OriM IITEOD \| OP CASES I ( I If 1 1 IAS a) t a) lot giTen I a) 0.38 ag/s vet vt I a) torlter b) 5 b) 0.29-0.45 ng/g »et at 1 b) lot given I tt controls 1 1 1 I Japanese aocler, 65 vr old, at 1 1 cbzonate rrcdaciag plant foe 30 yr 1 f 1 Bled cf aazillarr and long cancer. 1 1 Controls. 55-7* yr old. t t I-rar opectros 1 a) 7 1 1 VI 12 1 1 \| 1 1 1 1 t 1 1 1 1 I 1 1 1 »A 1 a) 5 1 1 W 3 t 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 Coloriaetrr 4 1 1 1 \| JJf»«: ADIJOSE T1SSOE; AOBTli BOIE I \| MItOf; BR1I1; CBtlSBlIDB; CEIIEXD 1 i mains: iiTEE; trass: mrsciES; 1 1 IIICBEAS; SM: CBBOBICPS: CCPP'fl; 1 \| HTALS; II 1C: IIBOSTSIAl M.AWTS; 1 1 IfBltATIOl; OCCUPATIO9AI HAI1BOS; i i icpoimo tnosniE 1 1 1 1 a) 35.3-182.9 ag/g; I a> 89.0 or - 57.6 I a! flotor teuton disease patients b) 19;7-11S;i «g/g I ag/g I t) Controls Brr «t I b) 06. J + or - 23.8 I lentral horn ttssm, antopsv 1 ng/9 \| 1 BT »t 1 latients tlef of svotropnic lateral 1 1 sclerosis and progressive nvsculae 1 1 atrophy, Kan a««. Si. 6 » or - 13.1 1 1 it. Controls died at various 1 1 diseases at <0.9 » or - 11.1 jr. t 1 t l itEis: »onis; Anopsus: i i •lOBoaoscniii DISEASES; SPIVAI ODII,- 1 1 tlOACCWglATIOI; CllCIOS; CCtPBB: 1 { IfCI; IHC; BtSEAXESZ; BIHlSj l i smnoR; ZIK f 1 1 1 < or » S.t ag/g (et I a) 2.2 + or - 2.1 I a\| (ales t) \| «g/g (wet vt) \| 1) feaales < or > 3.8 ag/g [vet I b) 1.3 « or - 2.2 I ) 1 ag/g («et "tl I Hot a groap of Cl autopsies. 1 1 forensic sedieal ezaiinatioo. Japan. 1 1 Bales, nean age «0.« Tr. Fewtles, 1 1 s«aa age 37.4 fr. 1 1 1 1 IIACE EtERmS; AOT07SIES; JAPAI; 1 1 AZ8BXIOI; IBSIItC; CtDBIOB; COB1LT; 1 i CEDOEta: CCPPEB: IBOS.- UJBCBBT; 1 i mm: IAGIISI«C lAifiAEisx; 1 1 PUSIDIDS; AHIROBT; SCAIDI08; l i ftiEiivR: inaiura; VAIASIM; znc: ( l ecu; BRomi; tiTEl: Hours: l i ctBZBtm: cttEBEimi: BEA»: ROSCIES; 1 \| FIICBIIS; SPICTI; LVKS; 10B1A; 1 1 IIETA1S; CO(IP«BATI»S CTAU7ATIOS: S!I: 1 \| rCMISlC HECICIIE 1 1 1 1 >} 22.8-7&.J ag/24 ar 1 a) 52.4 «g/2* fee 1 a) Initial levels i) 38.6-130.6 ag/2* kr I b) 89.7 ag/24 ar 1 t) Dorina 5 f leecine aallv :) 35.4-103.2 ag/24 hr t c! ''2.1 «s/2« hr 1 el S iars after leaclne vithSraral 1 1 t 1 B«altkr volnnteers. 1 1 1 1 CCIIEI: 1ETALS; limit 1E1AWI.ISH; l l tistASfS; mil: BICOD SIIOB; oint; 1 1 SK» CISEAStS; ABIIO ICIDS; Ball; 1 1 CCSPAIITITI tfAlOATIOIS 1 1 (MET PIG I) I BERBEICE 1 1 I I Bvodo, E. 1 SanU. 5. 1 Tarara, E. 1 Beshizoka, K. \| 1980 1 International Archives 1 of occupational and 1 Envlrannental Bealtb ': 1 i i i i i 1 Knrlaader, 1.8. 1 ratten. B.I. 1 1979 1 Annals of Veorologv 1 1 I 1 1 1 1 1 1 1 1 1 Tnknva, 8. 1 Sazaxl-Tasnsoto, 9. 1 Asano, It. t Terai, I. I 19BO 1 Archives of 1 Environsental fiealti 1 35 J1): 36-44 1 1 I 1 1 1 1 1 I 1 Kriabnaaachari, 1 K.A.V.B. 1 197* 1 Aserlcaa Journal of t Clinical Intrition 1 27:108-111 1 1 1 1 I ------- 7«»0-50-8 Itf 63.56, HP 1083 C. EP 25-95 C, TP 1 « Eg at 1«28 C, 10 as Bg at 1870 C (CO«TI0!D) TISSUE 3* S3 Orine ETPOSORE BOTCE lageStiOn 1MLTTIC1I MtBOt US 1 OH BIB OF C1SSS al IS bl 17 C\| 19 3} 15 B1IGS a) lot given b) lot given C) lot given d) lot given nil a) «3 + or - 51 ug/2» to b) 3« « or - 22 ng/24 ht c) 31 * or - 29 og/2* hr 4] 25 * or - 8 ag/2« hr CII1B1L IITOB«4TICI al Be«, Ion tlood pressure t) gen, high bloed pressure ct Boiaa, law blood pressure dl voiav, high blood pressure Slblects selected by blood pressure rank froi a prerioas stady. istiiatea dallT iitake. 1.5 ag. EolTneslai ccsLdanta of Tokelav Islands! croioed coDditioae, Eitsist«ce econo»T. Ren, seal age »i TC. aaa« ht 167 cm, aean «t 7» kg. «o««n, icaa age < yr, aeaa tt 16S c«, eaa tt 79 kg. CCfPEB; 11K-. BLOOD SEBBB; B1IH; I1ILS; mill; III liiLin EIJEBEICE BcKenzie> J. a. Guthrie, B.E. Prior. I.I. I. 1978 aaeclcan Journal o£ clinical latritioa 31:«22-2» Ccvaarla (9 CD CI) 1-««-5 C4-B«-02 » 16.1, HE 70 C. B? 291.0 C, It 1 na 89 at 106.0 C iissat 3«« Breatl zitosors sornt itUTUCU. 8ETHCD 8C-BS lOBBIE OF CISIS ?a (387 sanples) EilCE lot given asii 1.0 ag/1 Geoaetric etltitl tllOBHlTlQl teacacei at 25 C and 760 nn Bg 63.1^ occurrence Ic>er aad upper ooe-Sigaa Units 0.2« aad ».2 iq/1 KalthT, U-35 TC old, nonsaelciiig. or tan blacks and Caucasians. Cnlcago, II. tlgidlT-contcolled ciperiaeatal coidltions. HI1TI; tICCBOLS: IltllOIS; IDBLT5; CEtOBKlTIO ETOBOCMBOIS; TOIiTILE cieinc cosEcmtDS; BEILTH BIUBDS; IIR1I1TICI; SETltOLISI; HET1EOLITBS f FCPClltlOI ETPOSOIE; HBB1I ISSiS EETIEEICE \| Krotosrynski, B.K. Sraneaii, 5.H. C'Heill, H.J. 179 Journal of Inalrtlcal Toilcoloqy 3:225-23* Ctesol (8 CI) (»«» Ibenol, aethjl- (9 CI) 1319-77-3 C1-B8-0 BI 106.10. »P 10.9-35.5 C, BF 191-203 C, W 1 an Bg at 38-53 C TISSUE 3855 DCi DC HtOSOBE BOOTS Deraal ItllllTICtL flETHOD 9C • OHBI9 OF C1S3S a) 15 b) 10 B1IGE a) 8.8-128.5 ag/g creatisiDe b) 31.7-*. 8 ng/g creatiniae 9Z» . a) lot given b) lot given cziiau. iiFoaauici a) Controls t) (orkecs eiposad to chlocaphenols forkera in barbicide nanaf actariiig plants. 6I8BICIOES; HOB STB III P11ITS; CCCSPtTIOIal B1I»EDS: PESTICIDES: FCEOLtTIOW IiraSOBE: HMSOBEKin MTIODS; CB1CBIIS OESIIIC COHP00KD3; FE'IOIS; C»HD»; OBI1Z EZrZBSICZ Tan Boosialen, P. 3. Klein, t.l. Oranaond, I. 1980 International archives of occupational and Environmental Health 5:57-6Z ------- C»«M (8 CI) Eenxene, (1-nethylethyl)- (9 CI) 58-82-8 c«-Bi2 •I 120.15. » -96 C. BP 152 C. TP 10 » Hg at 38.3 C IISSIE 38S« Breath 3 §57 Breath I 1 1 1 \| \| Eiposms BOOTS 1 1 I AIA1TTICAL BETBOD SC/SS GC-BS I ITJSBBS I OF CASES 1 1 8 54 (387 saiples) 11KI lot detected-21.0 ng/hr I lot given t 1 1 8»l 2.6 ug/hr 0.3 It ng/1 SeoMtclc eiBiBAi. MFOSBATICI Ccipond related to norul xetabolisi. lo other details given. Cryogenic caipling technique. Beilthy eilitarr and civilian eeployees, 0.$. Air Force School of lerospace fledicine, ages 23-»7 yr. 3 iiokera. Efizms; CBIOBIUTEC STDBOCIEBOJS; CflCBIlE CBG1IIC COIPOWOS: csioBOBHiznis; FiocBin COIPOHIDS: fttits; ilcceotS: fins; 1DOITS «ca ------- CFClotuaM CC-112 II t«.1S, IF 6.5 C. 8P SO. 7 C, W 100 H Bg at «0.8 C 11551 3B59 Bianh nrlaa nfOSOBS BOOT! Bactal iiumcit KEf BOD SC-BS 9C/B5 IBB BBS or cisxs 5« (3S7 SMplM) IltEE lot 4ii "''" " 1Vl BUI 5.0 as/1 fieoattcic GEIIUL IIFO1BUIOI fcamcca at 25 C »a 7SO a* Bg (>.«t occirrtne* lover aid afpar oae-Sigaa limit* 2.7 " " BaalthT* IB— 35 fr old* BO&saolclngr attaa black* aad caacaxiaas* Chicago. It. KigiilT caatroll«9 axpaciMBttl coiditioaa^ IBUTB: llCOBOtS; IIUWIS; H>HMS; CILOBmTED STDBOOBBOIS: TOtlTILB OMUIC CClICinDS; HU1TB BHIBIS; iiBiUTioi; amioiisri: BiTteoims; tcroimoi iirostriB: IIBII tuts Ifl cfclohoaaol (aataboUta} Data also on solm.t* IB factocy air Icckara IB shoe teetorf IB Italy tBIBB; BTD10CU1OB3: BJRUO1IXES; lt»lT; HDoniJll ITIOSFBIBtS; imsmii neiEii: IIB potmriai-. ccciruioni Di«isis IIFEUVCE l-wtenrMkl. t.t. SmnBio, «.B. O'leill, B.J. Join! of InalTticil ToiicologT 3:225-23 BrugsoB** F. FaTaB* I. 1980 Toilcologr and applied Ptarneol04T 53:220-224 MtftTl~ 10B-87-2 C1-BU tl g.10, » -116.» C, BV 100,3 C. TT «» » Eq at 22.0 C II3S« Inath EMOSVBB iOOTI 8IVBS lire Bat OF cuts III6B lot 4tct«d-13«0 ag/ht Bill 1.6 ««/hr SCIEUL mOBMTIOl f CeipoMd fcoi aafcaoia orlgia. lo cthat latailt gitaa B«aUhT allltarr a>9 civlliaB «lplOTM>> 0.5. llr IOCC* School Of laroapaca Ratlcia. ages 23-7 ji. 3 not«n. minis; cBiosiBiTSD naaacaBBOist CBIOBIKS oiemc COIPOOIOS: CBtOBOBEIIlKSt FITOSIlt COBPOUIDS; IBZITB: HCCBOlSj THIS; 1BC1TS BETESBICE - COBkl«. J.P. Caap. D.J. »lch. B.I. znvlronwattl Health 30 t2(: 250-295 i ------- crelohaiase, 1,2.3,a,J.«-»axac!>loco-. alpha- (6 CIJ '--'"---ane, 1,2.3,»,S,«-ka)zachlaro-, (1alpha,2alpha.3beta.«alpha.5beta.6b«ta)- (9 MO.S3, 8J 1S9.S-UO C, BT 289 C, »P 0.02 u Ba, »t 20 C fISSVS J««2 Blood. MtU IUOSOBB soon 1 1 1 1 1 I 1 3t«3 1 1 Hood, \| 1 >kole I 1 1 1 1 1 1 1 f 1 , 1 1 1 1 1 39t» Bilk lumicti. HBfBGD BC BVBBBB i um RUI i snmi aronutoi i unmet OF CIStS 1 1 t 1 1 1 1 1 1 •I » of 19 I a) 1.-B.3 •o/l a\| 2. S af/1 1 ) 6eeral population - Continental t Kraathacker. 3. b) 8 o •« I b\| 0.7-2.5 aoyi b) 1.3 ag/1 1 o«th (»rban) 1 lleble-RoUuh, T. O 1 of SO 1 c) 3.4-29 ooyl c> 9.2 go/1 1 b) eeieral population - island I Ktal-), C. dj 28 of 14) 9.2-157 ««/! 28 \| f 1 1 \| 1 1 1 1 1 < \| 1 1 1 1 1 I SO-BC a\| t« \| •) lot detect! 1 b) 2 I b) lot applicable 1 1 1 1 \| 1 d) 38 ag/1 \| (ratal) I TkaleeTic, B. Geometric Mans I c) Sipoaod workers - Continental 1 Miner. I. 1 iccth (drban) I 1910 1 d) Xxposed vcckan - Continental t latamatioaal archive 1 sootb (arban) 1 of Occupational and 1 1 EntironaentU Malta 1 Oeneral ponalatlaa. a?<* «-79 rr. 1 «5: 2 17-220 1 occipatlocallr exposed >ock«n. »g»f 1 1 2C-62 ?r. IiaoslaTla. ( 1 1 I ivaostmi: MOOD saas: DBB; BOB; i 1 EM; CBLOSlliTED HTOBOC»EBO»S: \| I cnotitz oteuic COIPOUSDS; ( i iKicnorocicioBmu; PISTICIDBS; i l occopiTioiii nzuos; PESTICIDS i 1 1ISIB1HS; P05011TIOI RPOSOSI; BHB11 I 1 IttlSs VtStt UtttS I 1 1 1 1 a) lot detected I a) love Canal residents \| Bristol, o.v. b) 0. 1 09/7 \| b) Tolnteec. 1 positlre 1 19SO 1 man of polltiTe sasples. Ll»lt of I IP1-600/1-80-03S, «0 1 •eaaiireBeikt. 0.0a7 H4/9 I pp. 1 Cloself watched, sisiltaneons control I 1 sanplei vere got proiided for I 1 analysis aloaq «ltk tkose fro the 36 1 1 1 1 lore Cull area residents saaplcd. I 1 1 1 lacking Maninofal control at 1 1 I 1 literature data relatin to the I 1 1 1 significance of the Ion residues I ( 1 f 1 1 1 1 \| 1 1 CO- 1C GC/BS i 1 1 found la the field «»pl» analyzed. I 1 I 10 definite coacllalon* can be drava 1 < I fzoi ti« results repotted, \| < 0.1 o»/9 1 1 f fesideats of re Tor It. Controls, I 1 caplorees of the Snrtroueital I 1 Protection tamer »n4 aniTarstty I 1 «t«de«ts, forth Carolina. \| 1 1 1 III T01K; WOKH CIROIUI; B1OOD; \| 1 9MSWMJIT HrrBOJSj C9LOBITC OIXStBIC I I ccatoonDS; ctia&otztssKS: \ 1 iixicRioicBtnziz: POIICBIOBIITITEI) i l ntitmss poptrHTios SIPOSUSI I i i l i Wot applleafele I lactatlif lothcn 1 Kodric-Salt. S. 1 < Salt, t. I 17-«1 TT old* froa $lanaia Province, 1 Clie, K. 1 TvgoslaTla. 1 1980 1 1 Pesticides 1ooltorin ------- CfelokuaM, 1,2.3,«,S.6-li«iackloro-, beta- (» CIJ Crdektxu. 1,2,J,.S,6-t«nckloro-, (1alpaa,2beta,3alpfca,Jbet«,5ali>ka,6beta)- (9 3M-8S-7 Cf-B6-C16 If 290.83, M 31-31S C fsabliaes), BP CO C at 0.58 n Bg, TP 0.005 » Eg it 20 C TISSUE 3665 IdiBoaa 36 6€ Ulpose 3M7 lolpose IPOSOH BOOTS uumcu BBTBOD ec iD9Bm or cists 60 a) 27 ») 1 C) 1 UK* 0.23-9.79 ppa a) lot firea B) Bot ei»ea c) lot alien nn t GEimi lifotBino* i i _..._.... . _ . i 1 l«le« 1 I liposed persons IB tke United States, I tke letkailnndB, sseden, Israel. 1 Japan, VSSB, Poland* Gernanf* India, 1 Balgarla. Pakistan, lastria. 1 I elevated seTae cholesterol, abnornal 1 Its, or iapalraeat of Bearcaascolar 1 faietlOB a(t«r acvte ezpoata to I cciSi.Mti.OBi of pesticides, tat »ost 1 data sho« no adTerse effect* alter 1 lca«-tecB occupational exposure. 1 1DS1BT1; B'JISISU; GJBS1II: noil; \| IS&m; 31?l»; ISTHEB1MDS: IUI5TM: 1 tciiBD; iissu: svcDii; UIITID \| STlttS; IBIPOSE TISSOE; BlOOIi BLOOD \| tllSBl; »IOCI StMl; E3TTBBOCTTBS; \| HOSOCITES; BILK; UBISB; BET1ES-. I I»HH HUlBtS: OCCD?»TIO«U BKUOS; \| K>nmO« IIMSOK: ISOPtlSBS; I (ISTICIDIS; CBlOtllB OBSalTC I CCHOV1DS 1 . I 0.7« pps 1 laripkeral kidnei fat, roatine 1 patkoloqlcal eianinatlons 1 1 iqes « ao-ej jr, Belaivs I I fllSIO!!; kOTOPSIBS; >9IK)SB 1I3SOE; I SIOICCtHHI»TIO»; PESTICIDES; DDO; 1 cm: on: BIILDBI: ISPTICIIOB \| tfOTIH; SEllCBlOBOBEltraB; mguS: 1 cnoitis oBeinc conaams i I a) 1S.7 » or - 19.78 I a) tospital patients ppa \|k) 13 TT old Caaale «itk Tasko b) 0.7 ppe, fat \|c) as yr old aale wltfe chronic PCB basis 1 foiaoAlnq c) 2.0 ppa, fat basis 1 1 Japaa 1 1 IClYCIItOBmtlD BIPBEITLS: 1ST; 1 BillCBLOtOCYCLOBItllE; BLOOD fHSB»; I SYSTER; pzsuciois: utross nssns; 1 IIVR; KID1IITS: OBMIU9 1 lirEEEICE eicaaannv H.B BacOonali, I.E. »77 Icatozieoleor »d EaTirOBBeatal Safetf : 89-1 10 De-taBekaeere. I. Stearbant, f. Terstraeten, B. Kips, S.H. 1978 loileoloolcal Earopean leseareh 2(2) « 93-98 Isone. 1. Ibe, S. Takasatsv* H. aoki, >. Rikl. S. Palirara, K. 197S Tvkaoka Heiieal Journal 6* {10: 6 10-6 16 (Hit USB) ------- CTCloaexane, 1,2,3, .5,6-hexechl0ro-, beta- (• CI) Sigijs""' '•23'«s'~h"»eloro-, (1alpha,2beta.3alph»,abeu.5alia,6beta)- (9 CI) C«-IC-C16 II 290.83, R( 31V-J15 c (sgbliaes), BP CO C at 0.56 u Bg, TP 0.005 as Bg at 20 C (COfTIPOlD) HSSffl 38«8 Blood \| \| 1 1 \| 1 1 1 1 1 1 1 1 1 38 «9 Blood, plasna \| 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 3870 I 1 BlflOl, i 1 (kola 1 1 1 1 mosaic BOOM 1UITTIC1I \| suites 1 B1IGX RETROD i or cisss i 1 1 J 1 t 1 1 1 1 1 1 1 1 1 1 f 1 1 1 1 1 1 1 1 1 1 1 1 1 1 i 1 1 1 l 1 1 1 l 1 1 1 1 l l l i J 1 1 BUI i ert BUI nroiMTioi J 1 > 1 1 Izposet pezscas ia the onlted States 1 tka setherlaids, Svedon, Israel. I Japan, USSR, Poland, Gersanv. India, 1 Eilgarla, Pakistan, instrla. 1 1 Reported cases of hypertension. I elevated serm cholesterol, abnornal t IFSs, or iapalraent ot aearoanscalar 1 function after aente exposnre to 1 eoatinatioas of pesticides, bat sast 1 data shov no adverse effects after 1 long-tern occapatlaial exponre. 1 1 lostsiit BoieiBia: era^nt; KDU: \| ISmSl; J1P1I; IETRESI.UDS: PIKIST1 i JOHID: EOJSJ: SVIDEI; OBITED t STITBS; jiDIPOSI TISSUS: B100D; BLOO \| FI1SU; BIOOD SEBUB: SSTTBBOCrlES; \| XfOITOCTTSS; Et£K; VBIVl; BEfTZV; 1 HtllTB 3IZIBCS; OCCVP1TIORU R1Z1BPS \| \| \| IC7DUTIOI UPOS01B; IIOPIISRS: ( \| t I15TJC1DIS: CB10BIIE OBG11IC 1 \| I CCIPOBUDS tit 1 til 1 1 a) 2« la) lot given a) 1«.« » or - 1O.45 \| a) Hospital patients 1 b) 16 \| b) lot given ppb I t) Enacitted persons 1 O 37 J c) lot givea b) 25.5 t or - 22.01 I c) loa-eaaciated persons t d\| 1 It) lot given ppb I d) 13 rr old f«nale vith Tasbo 1 •) 1 I e) lot given O 14.3 » or - 11.00 I e] 2> rr old nale «lth tplastic J 1 P"P.b f •••etift And stonicich CttncBi? II d) 19 ppb I 1 e) 30 ppb \| Japan 1 1 1 1 1 1 I01TCB101IIITH> BIPBEITIS; BDT; 1 1 1 BCI1CBXOBOCYCI0RR1I3; BIO08 PlaSBl; 1 I i iropusus; Jipi>; atsnoinssnm. 1 t I SISTER; P-STICTDIS; JDIPOSE TISSUE; J 1 1 SC-EC a) 3» \|a) 0.2-O.C sg/g VI 11 \| b) 0.2-1 ng/g I 1 ZIVBR; BTXDIEYS: OREITUR 1 1 a) 0.3 ng/g \| a) love Canal residents, 50* (17) b) 0. S ng/g I rceitire candles 1 tl Tolonteers, 551 (6) positive 1 Maples 1 Bange and teas of positive sasples. 1 licit of aeasnresent, 0.21 no/g r Closelr natcbsd, sinnltaneoas control f sasples vere not provided for 1 analvsis along vith those from the 36 I love Canal ares residents aaipled. 1 lacking neaninvfnl control or 1 litcratare data relative to tie 1 significance of the lo« residees I fensd in the field sanpl«s analyzed. 1 nc definite conclusions can be drain 1 fios the results reported. 1 1 Residents of lev lork. Controls, j etplofees of tke Invironnental I Protection Igencr and inivecBitj I etedents, forth Carolina. 1 \| 111 TOM; HCFTH CtEOUti; BLOOD; \| RllStnEHEIT JITBOBS; CHLOBTIE OKU1C \| CCBKHHDS; CH08OBIXSII$: 1 «!i»cstoacsiHB»i: POITCEHOBIW ITIB i BtmnrcB Deichaann, J.B. lacDosald. I.E. .1977 Ecotozicologr and Environaeatal Safety 1S89-110 Inoae, r. Ibe, S. Takasatsa, R. loki, 1. Blki, S. W75 Fakaaka ledlcal Journal 66(10:610-616 ristol, D.I. 980 Pl-600/1-80-036, 40 P. (lilt IIGB) ------- t,2,3,a,S,«-texackloro-, beta- f« CI) t,2.J,a.5.S-kMckloro-. (1»lpka,2beta,3«lpka,,«bet«,5alpka.6b«ta) - (9 CI) CFdoaezaae, Crclohezane, 319-8S-7 CC-BC-C1C •I 290.83. IP 314-315 C (siblisea). BP 60 C at 0.58 u H« TP 0.005 » tg at 20 C (C01IIIUED) lissni 3871 I idler 3872 lint 1 \| 3873 1 lilt 387* Bilk, fat 3875 Oceatss xiposTOK BOOM I 1 1 1I1LRICU nraoo 1 1 i GC-EC oc/ss GC-BC man OP C1SIS 1 1 10 ») 1 b) 1 Inez t applicable ot applicable a. 1-18.6 o«/kg a) lot film b) lot given c) or - 1.51 I after iell»«rT- 5esidents of Osaka 1 of Occapatiooal and ppa 1 Prefecture, Japan, »aried fllets and I ZnTiroaseatal Health f) 2.07 « or - 1.00 \| (nviroBaental conditions. \| 43: t-15 PPa 1 \| 1 oiPH: iDoiTS; itctiTioi: niK: I I BIOCCTBOIITIOB; PE3TIC1DIS; OB5HIC \| I CEIOSin COBtOOlDS; POLTCmOBIUTE!) 1 \| EI»B?ITLS \| • 1 1 1 a) 23 ppa (fat basis) \| a) 73 YT old il« vltk coloa caacer I Inoae, T. b) «.1 ppa (fat \| c) 66 rr old aale with stonach cancer \| ibe, s. basis) \| \| Takaaatsa. (1. 1 Japan \| loki, ». 1 \| niki, 5. 1 I01YCELOBIIITID BIPBZ1ILS: DDT; \| Tnjinara, 1C. 1 EfTtClIOBOCTCIOBITilt; BLOOD PLISBl: 1 1975 I IZ07LISJS: J1P1I; GlSTBOIlTESnilL I Tuknoka aedical Jonraal 1 SIStEl; PtSlICIDBS; 1DIPOSZ USSUX; I 66(10:610-616 1 I1TZB; KI01ETS; OSIITIB 1 • 1 ------- Cyclohezane. 1.2.3,«,S.6-bexachloro-. delta- (8 CI) Cjclohezane, 1.2.3..S.6-hezacfcloro-, {1alpha,2alpha.3alpha,beta,5alpha,6teta)- (9 CI) 31$86~fl ce-B6-ci« H» 290.83, ft 141.5-12.0 C, BP 60 C at 0.3 mm Eg. vp 0.02 mm Bg at 20 C IISSOI 3876 Blood. • bole 1 1 1 1 1 1 1 1 1 1 EIPOSOIE BODTE 1ULYTIC1L BETBOD GC-BC J 1 1 1 \| \| 1 1 Bragg* 1 OF CASES i a) 33 b) 12 "se a) 0.1-0.2 ng/g b) lot applicable •Elf \| GIIIB1L IIF01B1TIOI 1 1 a) 0.2 ng/g I a) Love Canal residents. 9 (3) b) 0.5 ng/g 1 positive 1 b) Volunteers. «« (j) positive I Bange and Man of positive sanples. 1 Ilsit of aea sure neat. 0.12 ng/g 1 closely natched. sinnltaneons control 1 sanples vere not provided for I analysis along vita those fron the 36 j tove canal area residents sanpled. I Lacking neaningfal control or 1 literature data relative to the 1 significance of the lov residues 1 found in the field sanples analyzed. 1 no definite conclusions can be dravo I fron the results reported. 1 1 Besldents of Ren Tork. controls. \| eaplovees of the SBVlronsental I Protection agency and university 1 students. Vorth Carolina. 1 1 iti TOSS; lorrn cuoiiwi; BLOOD; I BIlSVBERni BETBOOS; CBLO8IIE OBG1BIC \| CCtPOOIDS; CBIOBOBEB2BWBS: \| BIIICB1050BIIZEIE: POLTCHLOIII1IE9 I ciPBirrts; popoimoB ETPOSBBE i IEFEBEBCE Bristol, D.V. 1980 EP1-600/1-80-036, 0 pp. Cjclohnane. ,2.3.4.S,6-hezacbloro-, ganna- (8 CI] Crclohezane, .2,3,4,5,6-hezachloro-, (1alpha,2alpha,3beta,al;ha ------- Crcloluave. f,2.3,,5,<-aexacaloro-, gmmmt- (8 CI) Cyclohexane, l,2,3,,5.«-a«acaloro-, f1«lpk«,2alpha.3bata,4«lpk«,5«lph«,«b«t«)- \|» CT) CS-B6-C16 It 290.95, BP g-aua-isoser crystals 112.5 C, SP 323.• C, 176.2 c it 10 mm Bg. TP 0.1« •• Bq at 0 C (COETIBDED) IIS5BZ 3878 IBlOtiC fluid 3879 Blood 3880 Blood. s«ma 3881 float, vbole IPOSDBS BOVTZ lEaimciL SETS CD -EC 8C-BC oc SC-IC B0SBSB F CIStS 25 IS 10 a) 2 of 19 b) 29 of SO c) 28 of 28 a) 33 b> 11 11(61 9-61 ppb ) 7-39 ppb I 15-75 ppr 1 W-136 ppb a) 2.1-6.7 ug/1 b) 3.6-30 ugA c) a. 5-98 ug/1 a) 0.1-0.6 ng/g b) 0.1-0.3 ng/g Bill 1 CEIIB1L XEFOBB1TIOB 1 lErElEICB 1 1 1 1 1 1 7.12 ppb 1 50 positive speciMBS I Saxena, I.e. Geoaetric I I Seth, T.D. 1 Pregnant soaen, siiilar ID 1 Bahajan, P.I. 1 locioecoaoalc level and dietary 1 1980 1 habits, lo occupational or 1 International Journal 1 accidental exposure. LUCXBOV, India 1 of Environmental 1 ' 1 Inalytical Chesistrv I flSTICIDlS; CHIOBK1TED HTDBOC1BBOBS; I 7:285-251 I CBLOBIJB OBGltTC COBPODIDS; ODD; DDE; I 1 Ell: IIDIl; FBE6I1BCT; 1B1IOTIC \| 1 ftOIB; P11CIBT1 \| 1 1 1 1 ) 18.9 or - 8.8 1 a) Controls, full-ten pregnancies I Sanaa, B.C. ib \| t) ire-tern pregnancies 1 siaaiqai. fl.K.J. 1 39.7 « or - 1.3 I c) Spontaneous abortions at less than I Seth. T.D. pb 1 8 «k \| Krishna Haiti. C.B. ) 73.3 » or - 32.2 I t BhargaTa. l.K. ppb \| icalthYf non-expose4, pregnant toaen. j natty, 0. I ages K-32 TT, InSia. \| 1981 1 1 Joamal of Analytical 1 IIDH; 4BOBTIOS; 1DHUS; TITOS ; \| Toxicology 5:6-9 1 BLOOD; 711CIR1; CORMB1TITB \| 1 tfllTllTIOIS; CI10BXI1TBD I 1 BTCBOCllBOS; CB10KIBB OXS1BIC \| 1 COBtOOBDS; I1SECTICID5S; P1SHCIDES; \| I IBSTtCIIB 11SIDOIS; POPntaTICI 1 1 UPOSH1B; P1I6B1BCT \| 1 1 1 \| a) 3.8 vg/1 1 at General population - continental 1 K rant hacker. B. b) 10. » ng/1 I seath (urban) \| llebic-Kolbah, T. c) 26 og/1 I t> Sxposei workers - continental 1 Krall, B. Geoietric leans \| aorth (orban) \| TkalceTic. B. 1 e) IzposeS workers - continental I Reiner, B. 1 scuta \| 1980 1 1 International archives 1 General population, ages 6-79 yr. I of Occupational an! 1 Ceeupationallv exposed workers, ages I Environsental Health 1 20-C2 yr. Yugoslavia. I (5:217-220 t TUGOSltVIl; BLOOD SETOB; CBLOHIB1TED \| 1 BIDBOC19BOIS: CHIOBUS OS61BIC 1 \| COHPCWKDS; HDD: DDE; DDT: 1 I BIIlCHIO8OCyC10BEIlBI: PISTICIDHS; \| 1 CCCOPITIOBU HaZlSDS; PESTICIDE I I BI5IDOIS; POEOIATIOI EIPOSDBZ; ROB11 I 1 1DTIS; 18B1I 1BE1S \| 1 1 1 1 a) 0.2 ng/g I a) tove Canal residents. 21! (7) \| Bristol, D.I. b) 0.2 ng/g \ positive I 1980 t b) Volunteers. 36" (») positive \| ISI-600/1-80-036, 40 1 B»ge ana nean of positive sasples. I pp. 1 lilit of neasureaent, 0.068 ng/g I I Closely latched, sinaltaneonE control 1 I saiples were not provided, for 1 I analysis along with those frcs the 36 1 1 love canal area residents saapled. 1 1 lacking seaningful control or \| 1 literature data relative to the I 1 significance of the low residues 1 1 found in the field saaples analyzed, I 1 ao definite conclusions can be drawn \| 1 fros the results reported. I 1 1 1 eaployees of the Environaental 1 1 Frotection Igency and university I 1 students. Sorth Carolina. 1 1 III TOBK; BOBTR CaSOLIBl: BLOOD; I 1 MkSnREHERT IBTBODS; CRLOBIBE OBGAHIC I 1 CCBPODIOS; CBL030BEBZ3BES; \| 1 BITlCRLOBOBtlZSRE; PO1TCBLOBIBATED I 1 EIPBIWT1S: CCPHL1TIOB EXPOSOIt! \| (HIT P»S!) ------- Cyclohexane, 1.2.3.>.5,K-heiachloro-. gam- (8 CI) Cyclokexane. 1,2.3,a.S.6-lieiachloro-, <1alpha,2alpha.3b»ta,(alpha,5alpka.6beta)- (9 CI) CC-IC-C16 II 290.85, BP ganna-iawBer crystals 112.5 C, BP 323. c, 176.2 c at 10 m* eg. TP 0.1* » Bg at «0 c (COBTIHUED) I 1 1 1 1 1 IIS30! 3»82 Bilk 3883 Placenta 388* I Placeata \| I 1 EXPOS9IE IOOII Ingest ion 1 1 1 I 1 1 numcu IUTHCD ec ec-sc oc-xc IBH8EB OF CIStS a) 21 b) 2* c) «5 d) S 50 ) 25 ) 15 > 10 BUGS a) 0-0.061 pp. b) 0-0.270 ppB c) 0-0.270 jpe A) lot given 62-1631 ppt ) 2-23 ppb ) 7-1 ppt I 10-6 6 ppb Bill \| SEBI11I IIFOtBaTXOI \| BBPEBBtCE 1 1 1 1 a) 0.011 ppa I a) (oral Bothers, fat basis I Pozo Lota, B. b) 0.037 PPB 1 M Orbaa aotbers, fat basis I Herrera Karteache, a. c) 0.025 ppB \| e) 111 Bothers, fat basis f Polo Yillar, 1.1. i) 0.000* ppB I d) 111 Bothers, .hole allk basis I topez-Giaenez, B. 1 Data for sni of all pesticides and I Jodral Tillarejo, 9. I ccifarisons vita Tains of other I Iglesias Perez, J. 1 laresttjaton qlven \| 1979 1 1 Berista Sspanola de I Inrsiag aoth«rs froa Cordoba region, I Pediatria 1 SfaiB \| 35(206) :93- 110 \| SF1H: IDOLTS; HUE; CHLOIIIZ OBG1IIC I \| COIPOmiS; PISTICIDES; IGBICDlTrei; \| \| iUSlL »B!IS; VBB1I aR31S \| 1 1 389.6* ppb I l positive tpeciMBS t Saxena, n.c. SeoBetcic \| I Seth, T.D. I Freaaant noaan, siaiiar in j Bahalan, P.I. 1 aceioeooaoiic level and dietary I 1980 j cabits. no occupational or I International Journal j accidental exposm. Lucknov, India 1 of EnTironaental j 1 analytical Cheaistrr \| flSTTCIDIS; CHLOSIlllTSO HTDBOCUBBOKS; \| 7:245-251 I CEIOBIIS OB«I1TC COBPOOUPS; BOO; DDZ; I j CtT; IIOII; PIE6I1ICT; 1BIIOTIC I \| I1UID; PlICIRI \| 1 1 1 I ) 8.9 or - 4.3 ppb \| a) Controls, fall-ten pregnancies I Saxena, B,C* ) 20.* * or - 8.8 j i) Pre-tera presiaancies I Siaalqui, S.K.J. pb \| c) Spontaneois abortions at less than j Seth, T.D. ) 30.6 » or - 15.5 I 1 »k (inclad«s fetus) I Krishna flnrti, C.B. pb I I Bhargava, a.K. I Bealthy, non-exposed, pregnant voaen, 1 Rutty, D. I aoes 18-32 jt, India. I 1981 I \| Journal of taalf tical I IIDI1; « BOB! 10» ; aOOLTS; FETOS; 1 Toxicology 5:6-9 \| EtOCD; PI1CIIT1; COBPJS1TITE I \| ITJLOITIOKS; CHLOEIIaTED I 1 BIDBOOBBOJS; CHIOBIIE OBGtllC 1 1 ccnpotnos: IISECTICIDSS; PESTICIDES; I I FISTICIDt BESIDDES; POPDL»IIO» 1 \| tlPOSDBE; PBE6I1ICT I 1 1 CTdoaexagel 1C8-93-0 C6-H12-0 II 100.16, If 2* C, BP 161.5 C, TP 1 BB Bg at 21.0 C TISSUE 3885 Ereati BIPOSBBE BOUTI iUIITICal IJZTBOD SC/HS OF C»S!S 8 »IGE lat detected-I.C ng/hr (MT.1 1E11 0.5 ua/hr S»GE) Glimt IIF01I1TIOI CCBcaul related to aornal netabolisn. lo other details given Cryogenic saapling teehnigae. Sealthv ailitary and civilian enplorees, D.s. lir Force School of lerospaee iledieine, ages 23-7 yr. 3 SBOkers. EtlTWES; CBIOBUATSB HTDBOCaDBOIS: CBIO'IS OSGIHC COBPOniDS; IBI1TH: aLCOBOLS; TBT1S; AEHITS BEFE8EICE Conkle, J.P. Canp, S.J. Belch, B.E. 1975 archives of Environmental Health 30 (2): 290-295 ------- CjcloaeiMol 1M-tJ-0 «-II2-0 M 100.1C. tt 2« C, 0 Kt.5 C. T* 7 M V? at 2t.O C (COBTHOED) 1I5SVI 3866 Breath IWOSOSI BOOT* iBunicu BBTBCD cc-»s B01BCB or cisss S* (387 saaples) MBGI lot girea BB1B 2.6 (9/1 eeoutric mnu iBfosBivxoB Manna at 25 C and 760 u 14 «5.6» occurrence loier and upper oae-Sigia Halts 1.03 aid <.« no/1 Bealthr, 19-35 TC old, a«»sw>kii<\|. vrtu blacks and caoc»siana. Chicago, U. Blqiaiy conttollei aifctiaaital eondltioaa. miTE; ticcHLs: iitisois; IDQHS; CBLClIIaTID tIDiOClIBOlS: TOHTI1! CIS1ITC COSfCtWDS; BEllTB BltlBBS; 1I11I1TIC1; BSTlEOlISfl; BniBOlTTIS: tcraimoi inosoM; TUB in »BE»S 1E7Z2EHCX Kratoszinaki. B.I. Bnuaan, G. a. O'Hsill, a.j. 1979 Jovrnal oX inalrtical Toxicology 3:225-23* 1162-K-8 Cn-H12-06 Bl 312.3. » 268-269 C <1)b«BiopTra»-1.11-aion«. 2.3,6aalrha,«aalp1ia-t«tcatiTdro-«-Mta(UT- (a CI) )- (9 CI) TISSHI 38)7 Hood. EtIM BUOSOIE BODTB laqastion llaLTIICll 8BTHOD BSLC IS •oHtm or cisis 1 files lot applicable •nil 3.39 »q/al GT1EB1L IIPOlRaTIOI CB adaissioD. itlatoiin aoarce •HkBOII. 31 it old black patlmt with hepatic carcinoaa. at latoiia-lB(air«d iaaone ceepoaoe. line eaaccE. Clotting tile alfeetal, deitt caaaad bf heaorrfcaqe altar ncqecf. JtClTS; C1SS EISIOIIBS; IBOFUS9S; HOOD SEBTra; ITLatOIXIS; CIBCIIOCBII; IttU« HITlBtS-. IOOB COHTIHIIVTIOS 1BFIBBICB tr«r. B.S. Bljes, 1.1. 1980 ZBTir<»Beiital Be search 22:«00-ao3 . latkTl- «€-37-7 C«-B12 El e«.1«, HP -H2.3 C, B? 71.8 C, TF 100 la Bo. at 17.9 C IISS01 3888 Breath 1 iBiinicit BETBOD OC/HS BBBBSS or CISES 8 IUGB Bat detected-11.0 ng/hr B!i« 1 1.5 ag/hr Ccifonid related to nocaal •etabolisi. fa other details gives CXTogealc aaipliag tectalgM. BcaltliT ailitarr and clTillaa eeplOTees. o.s. lie TOTCC School of lecospaee RedleiBe. ages 23-47 jr. 3 tmiBSS; CSIOBIBITEI BTDBOC1BBOIS: CBlOtIRE OB6UIC COBFOWDS: CBIOBOBEBZEBIS: FLOOBII! COBPOVBDS; IltlTH; HCOBOLS; TEI1S; 1D01TS BBFBIEICE "conkle, J.P. Caap, B.J. Belch. I.E. 1975 IXChiTCS Of OriroBaeatal Health 30(21:290-295 ------- C5-B10-0 II as.13, BF -19 C, BP 139.5 C T1SSTII 3889 Breath 1 1 ! I ElPOSmi BO1TZ 1 1 1 lliLIIICtt 1 \| I CC-BS 1 ( f 1 1 I t IIXBE1 OT CtSBS 5« R87 saaples) BJISI lot gir« BEir 0.329 ng/1 SeoMtric CXinil II'OMITIOS Beasorea at 25 C aid 760 is Bg 8.5V occurrence lover and upper ane-Sigsa Units 0.0«9 and 1.59 ng/1 aeilta-r. 18-35 vr old, oonssoklng, oilsn Hacks aid Caucasians. Caicago, II. BigidlT controlled •npcrineatal conditions. E9HTS: tlCCCOLSj 1ILIIOTS; 1DVLTS; CB10BIUTID BTDBOCaBBOK; lOXaTILI cosine coftants: mm BIZAEBS; IBRIUTIOB: BETIEOI.ISB: HSTisoirrss: POTULtTtOI ZIPOSD9S; nBS»» »EE»S JiriSElC! Kcotoszvnski Bt Bma«aaf G. H. O'Rvill, B.J. T979 7&QfBa:2 0-f AoalTtlca] loxicologv 3:22S~23« Cjatiu ;«64S-67-» 1 1 3890 1 Kail f J 1 \| 1 j EXK>5Sft£ BO ffll 1 ' 1IU.TTICU. JSTBOO ColorlsetrT OF C15SS 1 1 1 I I 1 J 1 BUS! a) 10.6-16. 2S 1) 10.7-is. »jr zirr vt 1 Mli I a) 13.3 » or - 1.61 b) 13. S or - 1.«« Dry t 1 i G11EB1L irFOBIaTIO a) Bxposed verk«rs t) Controls to association betveen dnratios of exposure and crstiaa content. lork«rs, 22-52 11 olfl, in vanaiion factory, rinlaad. IB! tO tCIDSj OCCVP1T10B1L BHASDS; FCFDUTIOI SIPOS01I; I1ILS; 7IS11BD lEffBncl KivillotO, . Fakarlnen, 1. 1980 International Archives of Occupational aai •6: 179-182 112-31-2 CK-B20-0 H 156.27, H -5 C, BP 23-209 C. TP 1 •* Hff at 51.9 C IISSOB - 3091 Breatk zzrosasz soni 1 UI.TTICII SC-HS or cis is M 1387 saaplee) IU6E Bot given "' 0.261 ng/1 seoxatric GE1IS1I IirOBSaTIOB Bea tared at 25 C and 76D n Bg 5(. 1 occori-ence Icntr »nJ apper oae-Signa Halts C.0t7 an$ 0.700 nq/1 EealtkT, 19-35 rr oie. aonsnoking. ntlan blacks and caacasiana. Cblcaqo, II. EiqidlT controlled •ipcriaeata) conditions. ElflTH: IICCBOLS; IlLHOIS; iDOlTS; cnoilRaTED ETDIOCkVSOBS; TOUT RE CIG1ITC C09KOBOS: l^alTB ElUEES; IIHltlTIOl-; BITieolISIj BBtlBOtrtSS; POT1HTI01 1IWSB?E: 1JBM 1B11S ISFE1EBCE KrotosxT&skl, 3. E. Brnnean, G. a. C'leill. B.J. 1979 Journal of analrtlcal Toiicoltxji J:225-2I« ------- 12-ta-5 1X exposed residents had bnrnllke skin lesions, sone with cbloracne ITILT; IDOIfSCETITS: MOLTS; US! EISTOBItS; CBlLBSei: 1DIPOS! TISSO!; EBtll; KIDIITS; LITIB: LDB6S; fllCSHS; RI11TH HnllSDS; IVDUSTBIU. 1CCIDHTS; IIOPLaSSS - IntopST tissue. Bepre seats cat recovery ?•• it oil vonaa »ho died of pancreatic carcinon 7 no after industrial accident in Seresc, Italy, 111 exposed residents had bernllke till lesions, sose "ith caloracne IT11T: IDOllSCeilTS; IBOtTS; CASE BISTOBIBS; CBItDSE: iBIPOS! TISSUE; tBi»; moms: LITIB: LDBSS; EHICBI15; BULTB BnZ»BS; IBDUSTEI1L UflBEICS I Seggiani, 0. 1990 Joarul of Toxicologv and SnTironnental Health 6:27-43 ' Beggianl, s. 1980 Joaraal of Toxicology and tnvironnental Health 6:27-13 (•SIT PICK) ------- Dlbeniofnran. 2,3.7,8-tetrachloro- •1J07-31-9 C13-B«-Cl«-0 BR 306 (COSTIBUBD) TISSBB 3695 Kidney 3896 liver 3897 lung 3898 Pancreas EIMSOSB BOOTB Xngestion Ingest ion Inqestion Ingestion IBalTTICaL RETROD RUBBBB Of CASBS 1 1 1 1 BUGS Rot applicable Mot applicable lot applicable . _ _ _ lot applicable BBaB O.OH ppb 0.15 ppb 0.06 ppb 1.04 ppb GEBEBaL IBVOBRaTIOB Autopsy tissue. Represents 60* recovery 5? yr oil HOMO who died of pancreatic carcinoma 7 BO after industrial accident in Seveso, Italy, 1976 All exposed residents had burnlike skin lesions, soae vlth chloracne mil: iDOtBSCBBTS: IDOI.TS: C»SB FISTOBI8S; CBILDBBB: IDIPOSB TISSUE; tBalB; KIDBIIS; 11788; IHBGS; EISCBS»3; BBILTR HIZISDS; IIDDSTBIaL iccioirts: iiopLaSRS lotopsr tissue. Represents (VI r«eoery ^5 yr old voian who died of pancreatic carclnoia 7 no after industrial accident in Seveso, Italy, t976 All exposed residents had bnrnlike akin lesions, soae with cbloraene ITUT; IDOLBSCBBIS; 1DOLTS; CISB BTSTOBIBS; CBILDBBB: JDIPOSE TISSUE; EBilS; KIBSBT3; IITEE; LOSGS; flBCBBSS; BIIITH BaZtBDS; IBDOSTBIaL ICCIOSSTSJ IBOPLtSHS •ntopsy tissue. Represents 60f recoTery. Calculated total body atount ao aq 55 yr old votan »ho died of Jancreatic carcinona 7 «o after ndastrial accident in Seveso, Italy, 1976 111 exposed residents had burnlike skin lesions, soae «ith chloracne ITalT; IDOIBSCERTS; ADULTS; CI5E alSIOBIBS: CBILDBBH; ADIPOSE TISSUE; IRtIB; KIDBETS; LIVBB: 10BGS; PlRCBEaS: HEALTH HAZARDS; IBEDSTBIU ICCIDB^TS: BtOPLASnS Autopsy tissue. Represents S9¥ recovery ?5 yr old voian «ho died of pancreatic carcigoaa "> no after iodoatrial accident in Seveso. Italy, 1S7« ill exposed residents had bnrnlike akin lesions, soae with chloracne ITALT: ADOltSCERTS; ADULTS; CASE HISTORIES: CBILDBEB; ADIPOSE TISSVE; ESAU; tlOIBIS: LIVEB; LOBGS: EJBCBSAS: BIIITH 8ATABDS; IBDOSTBIaL aCCIDEBTS: BBOPLASBS BErBBEBCB Peagiani, 6. 1980 Journal ot Toxicology and Environmental Health «:27-«3 tleaolanl, 6. 1980 Journal of Toxicology and Environmental Health 6:27-43 Beggiani, G. 1980 Journal of Toxicology and Environnental Bealth S;27-a3 Beggiani, G. 1980 Journal of Toxicology and Envlronoental Health 6; 27-03 oo ------- Cit«tyliilB« (8 CI\| T-Htantaiat. a-tvtjl- (9 CIJ 111-92-2 CS-«19-« II 129.2. Bf -69 to -59 C. Sf 155-ISO C, TP 2 ma Eg at 20 C TISSUE 389 Imtt EXPOSOIE MOTE 1IUTTIC1I BKBOD CO-SS B0HBBB or cisis 5 (387 aaaplea) I1IBE lot given •Ell 0.218 ng/1 Geoaetric GIIHII IfFOIBITIOI •eanrei at 25 C and 760 mm eg 6.5» occicrcnco loner aad apper oM-Sigaa Halts 0.043 »i 1.11 aaA RaaltkT. 18-35 Tt oil, nonaaofclnq. vctu blacks and Caucasians. Chleaao, 11. Siqidlr controlled cxperiMital conditions. E1IITH: ILCOWtS; IILXIOIS; tDOlTS; CILOIlnTCD ETDBOCtlaOHS; T011TIIS cseanc concnDS; IULTB HITJEOS; mtunci; aiTiEOLiSB; BITIBOLITES; iCIOtUIOl IIPOSBtS; QBB» »BUS B8FEEE1CB Krotoszjnaki, B.I. Bconeau, G.S. O'Kill. B.J. 1979 Joarnal of inalytical Toilcology Js 225-21* lM. l-nittoso- (« CI) Ittbaaaila. 1-MthTl-I-iiltresa- (9 CT] C2-1S-9 CJ-B6-I2-0 •t 1«.1. B» 152 C IIS5V1 3900 Blood iiposnBE BO or i iiunicki BRBOD GC t 1 B08B1B OF C1SIS a IUGI < 0.5-1.3 »9/al Bill Bot giTon GEIIUL IirOSBlTIOB tcfoce and after a«al iiqh in nitrate aid aecoadari aaiaea. Bo siqii:icant • ff«et of teal. 32 saaples. 17 and 30 yr old lapaacae. Possible BitiMailna foraatiao in lower SI tcact. JI»1B; ID01TS; HOOD; OUTS; raavtts; in«osiB»csi HIHEOLTTSS BlfBBEICE { 1 1 Taaaaoto, B. luada, T. Taniiura, 1. 1980 rood and Coaaetica Toilcoloqi 16:297-299 to4«cau« 112-M-3 C12-826 8B 170.3, B» -12 C, B? 216.2 C, TP 1 aa Hg at «7. 6 C TISSUE 301 Breath BXBOSOBE BOim BXTBOD sc-as IOBBEB \| or CUES 5» (3(7 MICE Bot given SEAM 0.130 og/1 GEEIE1L IBFOIBKIOB ... tenure! at 25 C and 760 la Hg 36.2* occurrence to»«r ani npjer oae-siqaa Halts 0.03* and O.W1 » ------- EC0079 (Id poatlnqs i» CHElimj. ITSStJ! 3902 Orise EISOSOE1 BOItl Ingest! on IIUTTICU BETHCD Badiosetry TOSSES or cisss « B«GS 0.407-0.022! I nilB 1 1 1 0.0161 cziiBii nroiRHiow * excreted in urine daring 96 hr after 50 iCi. Bost of dose excreted III faces, blood negative. EcaltliT volunteers, 22-39 jr old. FCOI JDKTrTES; FOOD PBESBBTMIVES: KT»BOIISI; JSIJtl: lEIZOfl SEFIBISCE Valsan, P-B. Carter. D.E. Prerson, B-i. Ealladar, S.C. 1979 rood and Cosmetics Toxicology 17:201-203 I 00078 (lo pcatinqs la CHUIIWI). irssmr 3903 Urine ( txtosns soarz Ingest ioa 1 HETHOD Badiosetrj t t IVXBSS OF CASES 6 lltSI 0. 028-0. 06JT JIEJII 0.0«« cittau, iirosHjTioi 1 excreted daring 56 hr after SO nci. Bost of dose excreted in ieces, blood negative. fOOT IDBITITIS; POOD PBSSIRIJTITIS; e(T»BOI,ISI!; OKIBB; 1EIEOH MMZZWU Ralsan, P.D. Carter, O.E. Brerson, B.t. Balladar, S.C. loot and Cosaetics Torlcol'igy 17:201-203 7S-1B-J C2-B-C12 «i S9.0. .T? -97.7 C, BP S7.3 C, T* 230 •> ffg at 2i C 1 TISSUE 1 1 1 1 390* 1 Breath JIPOSORl FOTI! I 19UTT1C1L \| BtTSCD OC/IS ' I 9tllBZE I 07 C1SIS 1 8 \| BIIGE 1 1 Hot applicable I 1 IEK t 1 trace aiout \| 1 1 GiitFiL riroauTror 1 CeiB»nd froi aikiova origin, la ether details giT«n. Detected la only 1 «61ect Cryogenic saipllag teehnigne. •ealttr illitarr and civilian employees, O.S. lir force Scaool of leroepiee ledicime, ages 23-«7 jr. 3 Eioken. fllllttS; CBIOBIHTEC Bn»OC»BO>S; C81OEH? OBGtUC COSPOOWDS; CBLOioanzEics: FLTCBII: COBKUHDS; EKHTI: IICCBOLS; T»1S; 1COITS SErESSJCE Conlclev J.P. Caip. B.J. •elch, B.E. 1975 Archives of EBTiEoaaeittal BealtL 30 (2): 290-2 95 I 1 I-' ! S i ^^ Ethane. 1,1-aichloro-2.2-bi9fp-clilarpaeirl)- (B CI) Eenien, l.l'-fZ.Z-dicltlocoethrlideaelbisia-chloco- (9 CI) 7Z-5«-« CK-B10-CH H 350.S6. BP 221-222 C tISSOB 3 SOS adipose \ BIPOSDBE BOOT! aUlTTICIL HETflOD OC IO93EK or CASES 60 111 1 I \ I I \ \ \ \ I1IGI < 0.10-1. 05 Fpa SE1I a. 27 pp» \| t \ » » It 1 * .-»- . _ i 11 i eEIEllL MPOtUTIOI Feriphenl kidwr ttt, rogtine pathological exaalaatio» «ge« 6 14-92 rr. S«liin« BltBITTS; inTOPSlES; 19IPOSI ISSHS; noaccmm&im ; TBSTICHIB,SS BBB; Kit ACT; DIlLmlB; S5TTIC91OB tfOTTDl" BnftCHLOROEmm LX10ME* •EFE8EICE Dejaxclciieere, ». Steacbaat. 1. Terstraetm, H. Kips, «.H. Toxioological European eesearcb. 2 (2) -.93-98 CBic»t« o»nc coBtovms' i i l«M «H — ------- mate, 1,1-diciloro-2,2-bi«(p-ctlorplienrl>- (« CD ecBte», l.t'-K.Z-dlchloroetbrlia'eMlblAp-ckloro- fS CI) 7i-5«-» C«-B10-C1» El 350.46, at 221-222 C (COITTKJED) nssvt }»« iniotic flail 3907 float 3401 Blco-5. «Una 3109 Blood, aeraa IPOSTOE coral luimcn BRHOD OC-SC SC-JC GC OC IDIBEB OF C1SSS 0 t 25 o> 15 CI 10 •1 139 b) 175 C) 199 d) 210 at 31 of •1 b) 20 of «« cl 10 of 19 at 35 of 50 a) 8 of 2 MICE 24 pp 1 lot 4etectable-23 ppb ) lot o«tect»ble-35 ppb ) lot detectable- «32 ppb a) 0-1.3 PFt b) 0-H.S ppt c) 0-5.0 ppb d) 0-1.2 ppb a) 0.5-2.1 ng/l bl 2.5-23 09/1 c) 3.«-17 09/1 d) 3.1-318 ng/1 e) 3.5-11 as/1 Uil \| SSIEE1L IJFOSB1TIOI I B!FEB!»CE 1 1 1 1 99 ppb 1 10 positive specimens I Saxena, B.C. ontcic 1 1 Setl, 1.0. 1 Pregnant vonen, sinilar In f Hahajan, P.L. 1 tceioecononic lerel ml Sletarr 1 1910 1 tabits. »o occupational or 1 International Joaraal 1 4cciantal eiposnre. Locknon, India 1 of E»riroua«ntal 1 1 Inalytlcal Chealstry I risTicists; CBTORIHITSO BTDBOCIBBOHS; i 7: 25-251 1 CH10HI1! OSG1IIC COIMOTOS; COO; DDE: I I tn; HDII: PRIGIUCT: IBIIOTIC i 1 MOID; ?llC!m \| i i I i 1 6.9 » or - 7.9 ppb 1 a) Controls, Cull-ton pregnancies 1 saxeu, B.C. ! 15.2 » or - 12.5 \| t) Fee-ten pregnancies 1 si.41i.gtii. I.E.J. pb I cl Spontaneous abortions at less than \| Setb, T.D. c) 65.5 + or - 129.* 1 « »V I Krishna Rorti, C.5. pb \| \| Bbargata. I.E. 1 H«alt»T. nan-exposad, pregnart mien, 1 Kntty, D. 1 ages 18-32 yr. U41. \| 1981 t 1 Journal of Inalytical 1 IlDIl; HOBTIOI; IDHT.TS; IITTIS; \| Toiicologi 5:6-9 t E10CD; •HCBITl; COBPIBITHE 1 t 11U.H1TI01S; CBLOSI11TED 1 1 BIDBOCUBOIS; CBLOEII! OBG1IIC I 1 CCBPOTIOS; 1ISECHCIGBS; PISTIdDES: t 1 FISTIC1DI T.IS1BDES: MPUllTIC!! I I ixcosa»; pBtenict i i i a) 0.1 ppb 1 a> Boral tlacks \| Finilea, J. b) 0.» ppb I t) ncfcu blacks I Priester. I.I. c) 0.3 ppb 1 c) Qrban Caucasians \| creason, J. P. 1) 0. 3 ppb 1 a) Boral Caucasians t Ha user, T. 1 I Pinners. T. 1 Ocbaa an! rnial cesltents of SC, I Banner, 6.1. 1 infants, children, adults, eiaerlr- 1 1972 I 1 lierlcan Journal of 1 SOOTH CUtOIIBk; 10VLIS; CHHCSE1; \| Public Health 1 SICIU 5TODI1S; BIOO1 PUSH; \| 62 (5) : 65-651 1 CCHftSITITE miOlTIOBS: ODD; ODE; \| 1 ttT: DISIDBI); PESTICIDES; \| 1 tCLTC9LOsn»ED BIPHEITLS; 115 1 1 tctiUTioi: fcoo coitiaimiioH; i I P'StlCIlt ItSIDBES; P050LITI01! \| 1 MtOSSBE; «VB1I 1HE15: OBBU IKllS \| 1 1 1 1 a) 1.1 us/1 1 a) General popalation - continental I Kraithacker, B. b) 6.4 ug/1 \| central (rural) I llebic-Solbah, T. c) 5.2 ng/1 \| t) General population - island \ Kr«l1, n. 11 11 ug/1 \| (coral) \| Tkalceric, B. e) 6.2 ng/1 I c) General population - continental \| lei nee, I. GeonetrLc aeau I contb (urban) \| 1980 1 d) Stpoael ocrters - continental \| International IrchiTes 1 north (urban) \| of Occopational and 1 e) Exposed »crters - continental ( Environnental Health 1 icuth (urban) \| 95:217-220 1 1 t General population, ages 6-79 yr. \| 1 Occipationally exposed workers, ages \ 1 20-62 rr. Tagoslavia. t 1 1 i TtJsesLirii: siooe stMH: CBIOSIHTED i \| gTOKOCiBBO'S: CEIOEIK! OPG1IIC \| 1 CCBP01HS: DEE: DOE; DDT: PESTICIDES: \| I eiiicaLOECcYCLottmii: OCCOPITIOHI i 1 BI11BC3; FtSIICIDl HESIDUES; \| 1 fC?0HTIOJ SirOSOBE; BOail UEHS; \| I mm issis i 1 1 (1EIT PiSE) NJ ------- Itaaa, Ifl-dichloro^^-bisfn-cUorphwyl)- (8 CI) Icrane, 1,1'-(2,2-dlcia.oroethTUa'en«)nls(-chloro- (9 CI) 7Z-5«-S CH-B10-C1* IE 3SO.««, If 321-222 C OS; ODD; 001; \| CBt! I»BI«: PBESIAICT: »H»IOTIC I MOID; CtlCERl \| 1 a\| 25 a) lot detectable-* 1 ppb b) 15 b) lot det«ctable-«2 ppb c) 10 c) lot detectable-75 ppb a) a.s * or - 8.3 ppl a\| Controls, f all- 1 era pregnancies I Saxeu, B.C. b) 10.7 * or - 10.7 b) Pre-ters preon ancles \| siddiqai, a.K.J. Ppb c) Spontaneoas abortions at less than I Seth, T.D. c\| 20-« « or - 22.8 9 «k (inclides fetas) \| Krishna Barti. C.B. PP* 1 EhargaTa, l.K. Bealthr. non-exposed, pregnant w»ien, \| ICnttj, O. ages U-32 rr, India. \| 1981 IIDI1; 1BOI1IOI: IODLTS; ?ITDS; [ Toiicology 5:«-9 EtocD: pticsiTi: cospiBiins i ttlLOaTIOIS: CBI08II1TBO 1 ETseocitgois; caws IK osciaic i CCBEOWDS: IISICTTCIDSS: PESTICIOBS; \| FISTIC ID I SISXDOZS; POPB1.1TIOS I IlPOSmS; 7BESI1ICT \| 1 M N5 to ------- !tku«. t.f.l-trlcaloro- 71-SJ-6 C2-BJ-C13 n 133.»2. « -3fl.«1 c, BP 7.1 c. TP too » 89 at 20 c 1ISSOI 341 Bteatk 391S Breath siMsnn BOOIE i in men IBTBOD ac/is QC'IS nun Of C1SIS 8 » (387 saiples) IMGE lot detected-1«0.0 ««/kr lot giren Bill 20.1 «g/nr 1.8 na/1 MOM trie 6Sltal tlFOBBlTIOB Cciponad related to nornal •etabolita. o other details glren Cryogenic gaipllag technique. SealthT illltarr and civilian employees, U.S. air Force School of lerospace Dadlclae. aq«s 23-47 yr. 3 >oter3. tiizms; cnotiiniD iiosoctssoss; CELOBIW oisinc coiMmas; CILOBOKIZIIK: HVOSIR COH001DS: IttKI; IICOBOLS; TEHS; IB HITS Masaccd at 25 c and 780 •• Bq 21.7 oeenrteBce Lo««c a«d ipper oae-Sigaa lilits 0. 2 aid 7.7 an/1 Bcaltkr. 18-3S TC old. aonsaokiaj. ottaa blacks aid Caucasians. Cfcicaqo. IL. llqldlT eoDtiollel cipcrlmtal coaditiom. HiiTB; IICOEOIS: iiLisois; units: CHIOHHTID ITDBOClSBOIS; 7O11TH.I CB61IIC CC8PCOIDS; SE11TH I1U8DS; IlHlllTIOl: IR1BOIIS1: HET1BOLIT8S; ccrmiTioi nposiii; eaTl)-2-(p-cUocoph«arl\|- (8 CI) Kaxeae. 1-cUoro-2-(2.2,2-trichloro-1-(«-cilocopbenil\|«tliTl)- (9 «l 7t»-02-« C1-B9-C15 81 3S«.»9, EC 7«-7«.«> C (coc) to U) 1ISSJB 3916 tlDlotlc flail 3917 (load. plasaa EXMSin BOOTI 1MLTIIC1L RZTBOD SC-BC ec miiBzs or CUBS so a) 139 b) 175 c) 199 d) 210 BUGS 0.5-11 ppb a) 0-2.7 ppb b) 0-3.9 ppb c) 0-2.7 ppt d) 0-1.6 ppb am 1.06 ppb SeoMtric a) 0.2 ppb b) 0.* ppb c) 0.2 ppb 1) 0.1 ppb Gzmii iirosBiiioi 15 posltiTe «p«ciaens tlegaaat voaca, siillai in habits. Ho occnpational or accileatal erposare. Locknoi. India ftSnciDIS; CHLOBI1ITSD HIDBOCABBOIS; CEIOBIIS OB61HC COBP001IDS; DID; DDE; BtT; IIBI»: ciEeiiicT: IBSIOIIC IIOID; PLicirri at Snral blacks t) Urban blacks c) nrbra Caucasians i) Bvral Caucasians Urban and raral residents of sc. infants, ckildrea. adults, elderly. SOOTH CHClIll; 1B8LTS: CHILCTEB; BICIJT. STUDIES: BtOOT) PLaSRl; CCIPtDtTIfZ miOMIOIS; DDD; ODB; Ctl; OTEIBBIB: PISTICISBS; EOIICBtOBIHTTO BIPBfBILSi tl<< EC11QTIOI: FOOD COIT»«H»TIOI: PISTICI9I BESIDDIS; POPOL1TIOR upasnB!: BOBIL isiasj OBBII nias BEFEBEBCB Sanaa. B.C. Seth, T.D. Hahalan. P.L. 1980 Internatiooal Joinal of ^nrironnental tnalrtical Cheaistry 7:25-251 Finklea, J. Priester. L.E. Creason, J.P. Baaser T. Binners. T. Eaaaer. D.I. 1972 taerlcan Journal of Public Health C2(5):6«S-6S1 (HIT P1S£) ------- Ithane, 1.1,1-trickloro-2-(o-chloropkeayl)-2-(p-ckloropli«Byl)- (8 CI) EeBxene, 1-chloro-2-(2.2.2-tricliloro-1-(»-chloropb«ayl)ethylj- (9 CI) 789-02-* C1»-B9-C15 81 35.«9. BE 7«-7».S C (cor) (CORIMIEO) IISSVE 3918 Placenta Exposure sotrtE 1BALRICAL BETHOD OC-BC IOSBEB OF CASES SO B1BGE 9-63 ppb BE I «9.63 ppb Geoaetric GZIE1AL IIFORBaTXOB 20 positive speciMIS Pregnant voneB, siBilar in socioecoaoslc level and dietary habits. Bo occapatiomal or accideital exposure, tncknov, India MSTICT9I5; CBLOBIBATBD HTDBCCABBOIS; CELOBiit OIGABTC COBPOOBDS; COD; DOE; CCT; nni»: PBSGBAICT: ABBIOXTC flUID; PLACIITA EErtiBBci Saxena, B.C. Seth, T.D. Bahamas* P.I. 1910 iBtecaational Journal of EnviroBaental Analytical Chenistry 7:25-251 tthane, 1.1. 1-tricliloro-2,2-bis (p-chloropfceofl)- (8 CI) tcnsm. 1.l'-(2.2,2-trlchloroetfcrlWeB«)bi»(»-ctloro- (9 CI) 58-29-3 CH-B9-C15 BI 3?.59. it 108.5-109 C. BP 260 C, TP 1.5X10(1-7) •• Eg at 20 C 1 TISSUE 1 1 1 1 3919 1 Adipose 1 1 1 1 1 1 3920 Adipose 3921 Adipose EIPOSDIS BOOTS IIALYTICAL B9BBSB BETHOO Ot CIS! 1 1 1 1 f 1 GC 1 60 7 BABGB .20-3.70 ppl t given MEAI GBIZBAL IBPOBBATIOB f BEPEBEBCB 1 ,._,.. 1 1 1 1. 52 ppn 1.4 * or - 1.26 ppn 1 B«vie* \| Delchnann. I.B. 1 tlacDonald. I.E. Exposed persons in the United states, I 1977 tfce setherlands, Sweden, Israel, I Ecotoxicology and lapan, USSB, Poland, Seraany, India, I Environnental Safety Bulgaria, Pakistan, Anstria. I 1:89-110 1 feporteJ cases of hypertension, I CEGs, or ispairsent of neacosnscalar I function after acute exposure to I 1 continatlons of pesticides, tat most \| 1 data show no adverse effects after I 1 long-tors occupational exposure. I JCSTBIl: BBIGARIA; GE8IA«r: IRDIA; 1 ISBAEL; JAPAI; BETHIBll-fBS: PAKISTAB; 1 tciiiD: BussiA; CTEDMI IBITED t STATSS: ADIFCS! RSSffE: BLOOt; BLOOD I PUSSA: BtOCC SEIOfl: !BrTBBOCr!S; \| KOICOCTTES: BILKj It lit; SETIE8: \| BIALTB fAZADCS; OCCOPATIOBAl HAZARDS; \| PCPOLITIOK HPOS08E; XEOPLASBS; I FISTICI9CS; CBI08IVE OSGAXIC I CCIPOtr»DS \| 1 Periok«ral kidney fat. routine ( De-jonckbeere, W. Fatbologlca 1 examinations \| stenrbant, I. 1 Terstraeten, E. Ages 6 so— 92 yr. Belgian I Kips, S.B. 1 1978 !E1«IVS; AUTOPSIES: ADIPOSE TISSUE; 1 Toxico logical European EIOACCISBLAtlOB; PESTICIDES; DDD; 1 Research 2 (2): 93-98 let; DDT; DiiiDaii: BSPTACHLOS i ITOIIDf; BEXICnoBOBEBZEIE: 1IBDABE; I CnOBIIB OEGAIIC COBPOHBDS \| Bospital patients \| Inoae, T. 1 Abe, S. Japan \| Takanatsu, 8. 1 Aoki, «. tOtT.CBLO^I«ATBO IIPBMTLS; DPP; I "liki, S. BIXACBtOBOCTtClOBEIABE: BLOOD PUSBA; ) Fnlluara, K. I'OPLASflS; JAP11; CAStBOIBTESTlnL \| 1975 STSTW1; PESTICIDES: ADIPOSE TISSITS; I Tnknoki Helical Journal 1 to ------- ma»e. l.1.1-triehloro-2,2-l:is(p-cliloropIi«»yl)- < ci\| e«a»l»r 1. f'-(Z.2f2-tricMoro«thrU«»)l>i«t»-chloro- (9 CI) Sfl-29-3 C1«-«9-C15 fl« 35«.50, HF 106.5-199 C. » 2«0 C, TP I.SXIOfI-7} u Bg at 20 C IISSBI 1 3922 1 1 1 1 \| \| 3923 1 Blood \| 1 1 392 Blood !IM50ra lOBII < SFTHCD SC-BC SC-EC in Bit or cis is l) 22 b\| 1* 4 6 1) 6 » 6 a) 25 b) 15 O 10 iiiei i Bill BMIUI nroMinoi'" i IEFBBIJCB ! i lot gives 1 a) 2.60 + or - 1.33 al Elderly >«• 1 BreTik. E.H. lot gives 1 sg/kg ») Elderly «csen 1 Bjerk. J.B. lot givsB 1 bl 1.86 + or - 1.»1 el Toang sen I 197> lot givee 1 sg/kg «1 T.on»g >oa«a 1 Icta Pharmacologies at lot gives 1 c) 0.95 * or - 0.26 e) levbocBs 1 Toxicologies 1 ,,/kg Perirenal tissue \|»3(1):5>-«3 1 d) 0.91 * or - 0.61 197C survey. Significantly higher in I I ag/kg elderly, particular IT in sen (P < I I e) 0.75 * or - 0.56 0.051. Significantly lower levels in I j i ------- I thane. 1.1,1-triehloro-2.2-bi(B-caloroph«Tl)- (8 CI) Bentene. 1.1>-(2,2.2-trichloroethrlldM)bls(-ehloro- (9 CI) •0-29-3 CW-B9-C1S 81 35«.50. BP 108.5-109 C, BP 260 C. TV 1.5110(1-7) » Bg at 20 C (COITIIOSD) 1ISSIE 392S Blood. Flan 392C Blood, plasaa 3927 Blood, 1 serai 1 1 1 1 1 1 BXKSOIS BOOTE 111LTTICU BETBOB ec 1 t \| I 1 I 1 1 1 1 1 ec I IUBBEB suet or CASES a) 27 a) Jot given b) 16 b) lot given c) 37 c) lot given a\| 139 b\| 175 c) 199 d) 210 32 of 1 < I b) 8 Of 19 1 C) 17 of 1 «« 1 d) 32 of 1 1 1 1 1 1 SO e) 7 of 28 a) 0.6-28.2 ppb b) 0.1-62.7 ppb c) 0.1-6.6 ppb d) 0-6.0 ppb BE1I a) 3.5 « or - 2.50 ppb b) 4.7 * or - 5.53 ppb c) 3.0 « or - 1.96 ppb a) 8.8 ppb b) 5.* ppb c) 1.7 ppb d) 1.6 ppb entail itrosaiTioi i BEFESEICE I i a) Hospital patients \| Inoue, T. t) Zsaciated persons j Ibe, S. c) Ron-esaclated persons 1 takanatau, B. 1 »oki, ». Japan I Biki, S. 1 rajivara. K. lOITCBLOBIIITB) SIPBEITLS; DM; I 1975 BEIICBtOBOCTCLOBRlIE; BIOOD P11SB1: I Tnknoka Redical Journal IIOPUSIS; JIPIB; G1STIOIITESTIML I 66(10:610-616 SISTW: PESTICIDES; IBIPOSf TISSUE; I IITEB; KigitTS; 01EITUB \| 1 1 a) (nral blacks I Flnklea. J. r) Urban blacks \| Priester, I.E. e) Urban cancasians I (Treason, J.p. 4) Baral eaacasiais I Banser, T. 1 Binners. T. Orban and rural residents of SC. 1 Banner. D.I. infants, children, ad«lts, eldorlr- 1 1972 1 Aaerican Journal of SOUTH ciaotm: IDOITS; CHILESEI; i Public Health B1CI1L STODIES; BLOOD PUSH; \| 62 (5) : 645-651 CeiPlBITTTI tYllDHIOBS: DDK: DIE; I ttr: tnunii; PESTICIDES; i EOITCBLOHIITID BIPBEBTLS; AIB I \| (CIITTIOB; FOOD COETMIBlTIOIi \| \| PISIICID! RESIDUES: POPVL1TIOB I \| EIPOSUB!; BOMl UB1S; BUSH M»5 \| 1 1 a) 1.1-5.3 ng/l a) 2.2 ag/1 a) General population - continental I Krauthacker, B. b) 3.7-17 ng/1 b) 6.1 «g/l central (rural) 1 llebic-Xolbah, 1. e) 3.1-39 og/1 c) 7.2 ug/1 r) Senacal popalation - continental I Krai-), B. ) 3.7-96 «g/l \| d) 15 og/1 a««th (arban) \| TkalceTic, B. ) 4.7-29 og/1 \| e) 11 ng/1 e) General population - island 1 tteiner, EJ 1 Seonetric >eans (rural) \| 1980 1 d) Exposed workers - continental I International IrcniTes ( north (urban) \| of Occupational and 1 e) Ixnosed corkers - continental I Environeental Health tenth (urban) I 05:217-220 1 Gmecal population, ages 6-79 rr. 1 Occapationally exposed workers, ages \| 20-62 rr. Tngoslaria. 1 1 TOSCSHTIl; EIOOE SB1!IH: CELOEIIITES I RTBtOClSIOIS: CBIOEI1! OBGIHIC \| ccnoowos: Dtt: DDE: ODT; i ifitcRtoiccTcioBixm: PESTICIDES; i CCCnPATIOIlI B13IIDS; PESTICIDE \| BISIDQES; POPO11TIOI SIPOS01Z; BBB»L \| IB IIS; ISBll UEtS \| (HIT PISS) N3 ------- , f.f,1-trical,oro-2,2-bis(p-ekloropa«Tl)- IS CI) ttmutt, 1,1-(2,2,2-trichloro»thrlUa»)i>LsH-chJaro- (9 CI) SO-29-3 CM-B9-C15 II 354.50, H 10«.5-109 C. 31 260 C, TP 1.5X10(1-7) mm Bg at 20 C (COITIIIBD) IISSBE 3928 Blood. senm 3929 Bilk 3930 Bilk 3931 Bilk tlPOSOlE ROOTZ i uimcit MBTBOD1 - BO-EC GC-IC BOHBSH p cists 10 25 a) 1» b) 11 c) 10 d) 9 URGE 8.0-135.4 no/kg lot given a) lot given l) lot given c) Rot given d) Hot given BEll \| GHIUL IBPOBBlTIOl 1 leviav 1 I Zxposed perscaa ia the United states. I tie letkerlands, Svedem, Israel, I Japan, nssi, Poland, Gernany, India, \| Bulgaria, Pakistan, avstrie. 1 I teportea easts of kypertension. 1 elevated seen cholesterol, abnormal 1 IT.GS. or iapairaeat of nenronscalar I fmction attar acute ezposare to I conbinations of pesticides, bat cost 1 data shov no adverse effects after 1 long-ten occupational exposure. 1 1 ItSTBIa; BOieiBII; GEBBliy; mil; 1 ISBlEl; JlPtl; IZTEBBLllOS; PMCISTal; 1 iClalD; BOSSU; StEDEB; UBITZD 1 ST1TIS; 1DIPOSE TISSUE: BLOOD: BLOOD 1 PUSH; B100B SBBVB; IBTTBBOCTTZS; I lIOKOCTtZS; HLK; OBI1B; BE»IE«; I IIUTB HIZIIES: OCCOPITIOIIL BIMBOS; 1 PCPD11TIOI ZXPOSDIE: IIOPLlSBS; 1 PISTICIDIS; CRLOBI1E OBS11IC 1 CHPOOROS 1 1 50.8 og/kg I lactatlng sotbers 1 1 17-«1 yc olds froa Slavonia Province. 1 Jugoslavia. 1 1 TOGOSLlVIi: IICTITIOR: SILI; 1 EI01CCHBDUTIOB: BOBat 1BE1S; 1 CBIOIIHTID BIDBOC1BBO1S; CBLOBI1E \| OBGaBIC COBPCH10S; CBLOBOBI1ZE1IS: I It I; DOT; BtllCBIOBQCTCLOHIIUE: I EISTT.CIDSS 1 180 * or - 10 ppb \| lilk bank donors I 1 California 1 1 cuifOMii: UNITS: IRLK; 1 IIOlCcniBllTIOl; LlCTaTIOl; DDE; DDT; 1 PISTICIDZS 1 1 a) 50 + or - 38 ag/kg 1 i) Csla. large indastrialized city b) «9 » or - 31 eg/kg \| r) Bergen, large iadastrialized city c) 39 » or - 17 ugykq 1 c) Barstad, saaller city vita large d) 29 or - 13 ng/kg I chenical/petrocaeiical complex 1 d) Porsgrvna, non-industrialized 1 fisting eonsanity 1 197* nrvey. Significant decrease at 1 all sanpling locations conpared to a 1 169/70 sarvay. 1 lotwgiaa anthers, ages 25-28 yc. 1 I ItlPOSZ TISSUE; IILK; COBPiSlTIVB 1 tvllolTIORS; K)B«1T: lOOLTS; I IDTOPSISS; inBOBl; DDT: CB1CBII1TED 1 BTBEOCIBBOIS: DDT: PESTICIDES: 1 ECITCB108H1TID BIPBEITLS 1 flIXT PlGZ) IEPB1E1CE eichiann, V.B. acDooald. I.E. 977 cotozicology and Environmental Safety :89-110 Kodrie-Snit. B. Slit, Z. Olie. K. 1980 Pesticides Bonitoring Journal 1«{1):1-2 narrod, J.E. asgnith, B.T. 1980 lev England Journal of 303(16) :9«5-96 Brevik. E.B. E-lerk, J.E. 1978 teta Pharmacologica et Toxicologica «3(1)s59-63 t-0 ------- Ittane, 1.1,1-trichloro-2,2-fcistp-cBlorapnenrl)- (8 CI) Ecnxem, 1. tI-t2,2,2-trichloroethylid«i>e) fcistl-clOoro- (9 d) C11-B9-C15 IB 351.50. IE 108.5-109 C, BP 260 C, »P 1.5110(5-7) •• Hj at 20 C tissos 3932 Ri Ik 3933 Silk, fat 1 393* 1 Placenta f 1 3935 Dtine » UPOSHEI BOOT! Ineestion 1 1 V - inimcii BET BOD BC OC-BC 1 i ec-Bc 1 » * tmtSt 07 CS a) 21 b\| 2« C\| «5 d) 15 a) 25 b) 15 C) 10 BUGS \| SIl 1 GEIIBJL IIFOBI1TIOI I KKBMCS 1 1 1 II 1 1 1 1 a) 0.045-33.122 ppa I a) .223 ppi \| »l faral lotters, fat basis \| POIO Lora, H. b} 0-10.361 ppi I b) 2.745 ppa \| b) Orban aethers, fat basis I Berrera Racteache. 1. •e) 0-13. 122 ppa 1 e) 3.««1 pp» \| c\| 111 letters, fat basis I Polo rillar, l.S. fl) Tot gi»«B f S} 0.06S ppa I 4) 111 lotlieia, (hole ail basil \| Lopez-Gineaai, H. t \| Data for sei of all pesticides and \| Jodral Tillarejo, B. I \| cciparismB «ith Talus of other \| Iglealaa Perez. J. 1 I investigators qiven \| 1979 1 1 I Fevista Ispaoola la 1 I Bursinii aethers fro* Cordoba region, I pediatria I \| Spain f 35(206) :93-1 10 1 1 1 I i spin; IDOLIS: aziK; cmoBiii osunc i i i ccepooiDS: pEsnciots; IGBICHLTD»E: i \| \| SIBIL IBUS; DBB1I 1BE15 \| t t i a) Hot ot gifen \| ppi \| f) 1977, 20 saiplas I Hanita, If. 1 d) 0.1* » or - O.tS 1 \| 1979 1 ppa \| 100-11 lactating «oaan, 2 acaths \| International archirea 1 e) 0.49 » or - 0.18 I aftc dallrecr- lesideats of Osaka 1 of Occupational and 1 ppa \| Irf«ctre, Japan, varied diets aad 1 £Blrona«atal Bealtb 1 C) 0.29 » or - 0.09 \| e»iroaeatal conditions. I 13:1-15 1 PPi 1 { I i iisTicmts: SOT: OBGMIC CHLCBHE i I \| COIPOVIDS: JIM: tDHlTS; UCTaHOI; \| I i (us; iioiccoauLtTio: i i i FciTcnoimiiD iipaariLS i i i lot detectable- 1 • ppb Rot detectable-55 ppb Rot detectable-210 ppb 1 1 at «. 1 » or - 3.9 ppb 1 a) Controls, fall-ten pregnancies i Sazeaa, g.c. b) 19. S * or - 14.9 \| t) Pre-tere pregnancies \| slddiqni, H.H.J. PPb 1 c) Spontaneous abortions at less than I Seth, T.D. ct 57.2 « or - 71.8 \| « »lt (iaelades fetss) \| rtishna Sarti, C.S. PPb \| t Eharga»a, I.E. 1 BealtnT. non-ecposed, pregnant vonen, \| KnttT> D. 1 age 1-32 ji, India. ) I9B1 1 \| Journal of inaljtical \| HDI1: 1BO»TIO»: iDBLTS; FlIOS; I TorlcologT 5:6-» 1 EICCD: Pticsni: COBPIBJTITE i I iTitaiTions ; cnosiiaTis i 1 BltSOClSBOIS; CBLO8IR OfiGMIC I 1 CCSMHI3S: IISECTICIDBS; PISHCIDKS; 1 1 PISTICI3I SZS1BMS; POPtTHTIOf 1 t 'IPOSBRI; PI1GMKT \| ....._ 1 1 ) leviei \| Delchiana, U.S. 1 I EaeDonald, 9.5. I Ciposed perscus in the united states, I 1977 1 the Vetherlatds. Svedea. Israel, I Zcotoxicology aad 1 Japan, 7SS?, Poland, Gertany. India, 1 Zniitonaiental Safety 1 Eolgaria. Pakistan, Instrla. 1 1:89-110 1 1 I Beported cases of hrpertensicn. \| I elentel cer» cholesterol, abnorial \| I lC€s, or iapalraeDt of nearcaascalar 1 1 function after acate exposvce to \| 1 coiblnatiois of pesticides, bat cost I 1 data show nc adverse effects after \| t lon^-teri occupational eiposnre. \| 1 I I nsni: BDIGUII: GIEBUI; noit; i \| 15BIB1: JIPII; IRHE1LH1IS: PKISTtl; I I ICIIDOT SDSSIl; SH5DII; DIII1D \| \| S11TIS; 1DIPCSI IISSUS; B1OOE: B100D \| \| PlaS<»; B10CS SUDHi SBTTBEOCTTBS; \| \| ItOKOCTTJS; BIlKi B81IE; BBflHi \| I B1U1R IIZUIS: OCCVPtTIOIll HaZlSBS; \| \ IOI1HTTC1 EIPOS01I: IZOIlaSHS; \| \| ftSTTCT«lS; CffLO»II OBOHTC \ \ CC1VOUIQS \| 1 1 N3 c» ------- It It, 1,1.1-trlcfcl<>rQ-2.2,2-trlflaoro- 3f«-?8-S cz-ci3-M (f 187.38, Bf 1«.2 C, n »5.« C TISSUE 3936 lr«ath ElIOSOBB EOOI I IBlimcAl arm CD ec/«s IORBER or cis is 8 EIBGS lot detect «d-580.0 ng/hr " mi 88.3 «g/hr GEItlAI. IirOBBATIO Pntiois eiposare to conponad. lo ether details gives Cryogenic saiplinq technique. lealthv lilitacy ana civilian employees, O.S. air lore* School of Aerospace BediciM. ages 23-»7 yr. 3 iiokers. tllZEBES: CBtORMATII BYDBOCABBOHS; cnoBii? otcinc coieonos; CBioBomznis: twonn COBPOOIBS: tsuiH: iiccBots; TE»S: iiniis BEfSIEBCE Conkle, J.P. Caip. B.J. Mich, B.I. 1»T5 lICklTQB Of Imlronaental Bealth 30(21:290-295 IthtM, 1.2-dichloro- 107-06-2 C2-B1-C12 (I 98.98. BP -35.36 C. BP 83.5 C. TP 100 •• Ho. at 29.4 C IISSO! 3937 Ircath IIPOSQtS SOUI1 \| 1 1 1ULTTICU. BRBOD 6C/BS KDBBIB or cists 8 ItlGB Bot 4at«ct«d-0. SO ng/hr Bill 0.10 ag/kc SEItitl IBfOBBHIOB Coipomi froi ankaovB origin. lo ctfc«r details qiven Crroqenle saiplinq techaiqae. Bealthr lilitacr and civilian eiplorees, V.S. lir force School of lerospaec Dcdieliie, ages 23-07 jr. '3 linkers. EtKtRSS; CBIOBIIITZE BTDBOCABBOHS ; cnosm oBsinc COBPOVIDS; CB1QBO!BB7IIIS; FID C8 I IB COBEOUBDS; MllIH; HCOBOtS; THIS; »BOITS BE rial JOB Conkle, J.P. Caap, B.J. Belch, B.I. 1975 archives of EnTiroBMntal Health 30(2);290-295 K) VO Ithanol. 2.2,2-trichloro- 115-20-9 C5-B3-C13-0 ft 1»9.«2, BI 18 C, B? 151-153 C •ussot 3938 Blood EIPOSOB! SO01E Inhalation • UUCTTCll RETBOD GC BDHEEB or CASES 5 - S1IGZ \| 1 _, a) 0-2.8 ng/al b) 0-1.* ug/»l - - - (HE IT 9E1B 1 a) Bot given b) Rot given PJGI) 6ZBCB11 I1FOSBITIOI a) 10 hr and day 5 of SO ppi tcichlocoethvlene, 6 hr/daj, on 5 conaecative days t) 10 hr and day S of SO tcichloroethvlene, 6 hr/day on 5 consecative dars plas ethanol pcetceatcent. Ethanol given to •aintain blood level of 0.06. 20-26 vr old students. »t 62-77 kg. CBIOSIBJTID BTB8OC»BBO!IS; 1LCOHOUC ItVntASES; BIOOD; BLOOD PL1SB1; OIIIE; HETIB01ITES: DEMBOIISJI: 1 CULTS; GTIBAtT EEfEBSBCE Buller, G. Spassonski, B. Benschler, D. 1»75 Archives of Toxicology 33:173-18» 1 ------- Itbanol, 2,2,2-trlcUoro- 11S-20-8 CS-B3-C13-O ft 149.12, » It C. EP 151-153 C (COITUOED) IISSOI 3935 Urine Eivosns BOOM Inhalation 1U1TTICH. BETH CD 6C IOEBSB OF C1S3B S B1ISE a) 160-35 19 i) 120-10 •? mi a) lot giren a) Rat 9iren Giimi iiroifliTios a) Day 5 and 6 of SO ppa tricliloroetfcTlsne. 6 hi/day, 5 consecutive days. Initial value. 102 •9 n day 1 ttieiloreetnyleita. 6 ar/day, 5 ccase«ti« taya plas ethaiol Tt«tr«ata«nt. Initial valv«, 70 ug on ttl 1 2 ar etcretloas. Itaaaol glren to •ajatalt blocd !«»«! of 0.0«%. latiaatea fcoa grapi. JO-26 yt 014 stqdoata, lit «J-77 kg. CELORX1HED HIOROCIBBOSS: 1LCOBOLIC I1T1»»SIS; IIOOD: BLOOD PLlSOi; mil; arriBOLiTES; HBTISOLISH; i coirs : sEtauy i ssnetici Bailee. 6. Spassovski, B. B«nschlrr D. 197S Jlrcbives of To xl colour 33:173-18» Rtciw. dicalorodlfloaro- i71«-03-2 «« 133 TISSUE 3940 Br«ath 1 1 i 1 ElfOSOBB BOgiB 1 1IURJC1L I BETIOO 1 GC/IS VDflBSS or cisss 8 f I B1IGE 1 f lot tat«cted-0.029 og/ir ' BE19 0.009 ag/lr t GEIIiil IKFOIRaTIOI FreTioos czpasnre to coipoimd. Ho cttor datailc qi»«n Ciyogeaic saapliag technigae. acalthy ailitary aad ci»ili«o •aploye«sr 1?.S. lir FOTC« School of lerospace Hedicin«v ages 23-47 yc. 3 saokecs. CIIZEVIS; CHlCSHlTtt BTOIOClBBOlS; CKOBTKB oseinc coipotmos; catCHoetmns: PLHORISE COIPOETIDS; fBHTB; 1ICOBOLS; TlliS; iBOlTS 1 BEPE1EIC! Conkle, J.P. Caap» B.J« »elch, 3.1. 1975 ArcbiTM of EavironBental Health 30(21:290-295 CO o Itljl aleohcl (8 CI) Itaanol (9 CI] C2-B6-0 It 16.07. U -117.3 C, BP 78.32 C, tp HO an Bg at 19 C IISSOI 391 Blood t EIPOSIBS BOOTI Inhalation IIIITTICII iZTICB GC •OJIBIH OF CISSS 6 1 BIIG3 a) 0. 039-0. 06« b) 0.0»3-0. 073S 9X11 a) 0.0541 bl 0.059^ GEitui irroasiTicu .. a) la trichlcioethylene treatieit b) 100 ppa trichlorOBthyleoe Sange amd icaa for 6 \t period 20-26 yc old students, vt 62-77 kg. CILOEIlkTID BIDBOCIBBOSS; AlCOHOLIC HflBlSIS; BIOOD; BICOO PllSSl: DBIBEl II'TJBCIITES; 15T»BOIISn; icnirs; GIB tin IBFEBZICE Bailee, G. Spassovski, R. Peosciler, D. 19.75 iTcbiTes of Toxicology 33:173-189 (1111 PaSl) ------- alcohol (8 CI) ttiaaol (» CI) CJ-B6-O » ««. 07, BP -117.3 C, BP 78.32 C. TF «fl •• tg at 1) C ttSSVt 3M2 Breath 3M3 Heath 39M Breath nposm SO«M 1I1XRIC1I BET BOB ec/as SC/IS SC-15 BffBEJB or cisxs 6 5* (38T saeples) I1IGX 0.05-0.36 ppe lot oetected-MO.O «g/ar lot ai»« nil 0.13 ppa 136.1 no/he 9.* ««/! GCOMtClC eiHui nrosniTioi Corrected for level is inhaled air tcaltir adllt* sunn: HQHS: BHSITEIBT«I IRBOVS; fiinioL Coipani rtlatei to normal eetahollai. lo otter details girea Crrogenic Baiplla? technlqve. Bealtkr "Hilary u« elTlliaa caployees, U.S. ail force School of Krespace s«dieia«, aqea 23-T Tr. 3 giotori. iiizms; cnoBimit ITDBOCHBOIS : CBIOUMI oistric CPHPOTIIDS: cnioBomznzs: n.0otm COBPOOIDS; isiiTS: iicoiois: tnas; IDOLTS Kanrei at 25 C aid 760 >a B? ------- Ithyleae (8 CI) Itnene (9 CI) 74-85-1 C5-B4 HI 28.05 C. IP -169.» C. BP -103.9 C. TP 100 •• Bg at 131.8 C TISSOB 3946 Breath EIPOSDSS BOOT! ininiciL BSTBOD GC/BS BOB BIS or CISBS 8 BMGB let detected- 120.0 ng/hr BZ1B 1S.1 «g/hr GEIZUL IIFOR81TIOI Ccsponad related to noraal Htabollsi. le other details given Cryogenic sampling teehnigie. lealthy illitarr aid ciriliaa employees, O.S. lir force School of lerospace Bedieiae, ages 23-47 jr. 3 ciokets. tiixnts ; CBIOBIBHBD ITOBOCISBOVS; CBIOBIK OBGIHC coiPooiDS: CBioaoBE«u»is: FIOOBUE COBFOOIDS: iiiiTB; iiccEois: TBIIS; IDOITS BErXBEICB Conkle, J.P. Ca»p, B.J. Velek, B.B. 1975 •rchires of BoTiroBMatal Health 30 (2): 290-295 fthylene, chloro- (8 CI) !th««, ebloro- (9 CI) 7J-01- C2-B3-C1 BB 62.50, BP -13.« C, TP 2600 •• at 25 C I IISSOS 1 1 1 1 39»7 Breatk XtPOSDBB BOOTI I 1ULTTIC1L BDHBS I BBTBCD OP C1SIS 1 1 Inkalation 1 GC 5 t 1 1 1 IIB6B a) lot giren h) Bot gl«n c) Bot givea d) Bot gi»«» e) Bot giT«n f) Bot given 1 1 1 1 1 1 1 I 3948 1 Ereath 1 1 1 6C/ES \ g ug/kr IStl a) 27.6 eg/en • b) 11.2 »g/cu a c) 5. 8 ag/cu e d( 2. 8» «g/co a e) 1.30 •g/Cd a f) 0. 5» ag/ca a 0.09 tigXhr GBIZB11 I»FO»»»TIOI a) IieeJlatcly after $0.0 ig/co • fc) leieaiately after 30.0 ag/ca • e) lemediately after 15.0 ag/ca • 1) 30 lin after 60.0 ag/ce e e) 30 ala after 30.0 ag/cn e f) 30 iln after 15.0 ag/ca • 6 hr ezposare Bealthr 26-31 ji olds, Poland. fCllBD; 1D01TS; BB51TH; TIITI CCBPOOMDS: lIBllaTIOl ether detail: glTea Crrogenlc saipllag technique. Bealthr allltarT and cirillan eeployees, O.S. »lr Force School of lerospace Kcdiciae, ages 23-47 yr. 3 eiokers. IIBIZVIS; CBIOBIIHTIt BTDBOC1BBOBS: CEIOBIB« OFGICIC COIPOVVDS; CB10BOBB1ZZIIS; FLUOBIIE COBPODlDS; EDIITR; HCOB01S; TZXtS; IDOITS BErZIBBCZ Itralenski. J. Oobeckl, B. Groaiec, J. 1980 British Journal of Industrial Bedicine 37:373-374 ConJcle* JP. Caap, B.J. Welch, B.B. 1975 IrchtTes of Environaental Health 30 (2)! 290-295 CO NJ ------- e-m. cUorofJaoro- (S CJI cMeroflsoro- (9 CI) m.« TIJSBB W»9 Eceatk UFOSIIS MOTE auirticiz BRTHOD SC/HS units or cisxs - a 1161 lot detexrted-a. 5« uoybr mi 0.07 ng/br .. 6EIEML IIFOIBUIOI C«ipomi ftoi uk>an origin, to other details qln CXTogeaic saapliag technique. icalthr lilituy and civilian tiploTees, U.S. lit Force School of lerospace ledicise. ages 23-H7 jr. 3 ssokers. {IllntS: CgUMXIHEO BTDIOCUBORS: CdOBin O8G1HC COIIOniDS; caiOBOinzms: TUJCEIH COHEOBHDS; I«1HB: HCOEOtSj THIS; 1I101TS 0E^£BEVCE Conkle. J.P. Cup. B.J. Mick, B.E. 1975 lrctiT«s of iBTirouental Maltk 30(2):2«-295 tctcuckloro- (8 CI) Eth«M, tctcachloro- (9 CI) 1IT-H-I ea-ci« II ISS.85. It 121 C 1ISSOI 3950 Blood 3951 Brain 3952 Breath 1IMSVEB BOOH \| IHITtlCtt Inhalation Inhalation Inhalation HETBOD 8C-IC GO-EC OC WttSBS \| BUCK \| BE1I \| 6E1IU1 HF08BIIIOI OF C1SES \| \| \| 1 I 1 1 a) 29 b) «2 ------- tbyleae. tetrackloco- (8 CI) Etteae. t«tctchloro- (» CI) C2-CM It 1«S.«, » 121 C 1ISSO 353 tteatk 35* Bceatk 3»55 3956 39S7 » xuosviE to nkalation •talatlon kaUtloa 1U1TTIC11 HBTBOI) GC/iS OC-9S 8C-BC ec-sc EC B1MBXB OF CUE M (387 uiplos) HUBS lot detect«d-2. 0 ag/hr tot 9! ren ot applicable ot applicable applicable BEil \| GBIIMI ZirOIMIIOI \| BEfEtEICE 1 1 1 1 1 1 0.3 ag/kr \| Ftcvloa* eipcnre to compotmS. la t Cockle, J.P. 1 clker details give* I Cap, B.4. I Cryogenic saaplUg technique, i lelek. B.E. 1 1 H75 1 Bealthr ailitary ud civilian \| ircklres of I eiplorees. U.S. Air force School of t Environmental He a It k 1 aerospace ledlciM, ages 23-17 jr. 3 1 30 (2) :2»0-295 1 stolen. \| 1 1 1 ftnntSt CHOSIHTED BTPBCC1B30HS; \| 1 cnoiiBS oBsirtc COBPOOIDS: i \| CIlOIOEMZHtS; FLDOBIII COBPODIDS; I 1 iiiHi: itccBois: THIS; unts i i i < i 2.6 ng/1 \| teasared at !5 C aid 760 •• Bg \| trataszfBslEi, B.C. Seoeetric I 30.2V occurrence f Braneaa, e.g. I I8«er ••< «ppsr on«-Sig»t Halts 0.51 I O'leill, B.3. 1 aa4 13.2 ag/l \| 1»7« 1 I JoaruL of analytical 1 Beeltkr. 18-35 TC old. nonaaotinq. I toxicology 3:225-23 1 oi tan blacks and cancusflaas. I ( CUcago, It. tWiJlr-contrellea I I experimental conditions. \| 1 1 I IBHTH; atCCBOLS; IILtfOIS; 1DDLTS; I \| CBlOKiriTEB irDBOCJBBOMS; rOUTHI \| ( cxeavic COBPCOMS; SEU.TH sir IB us; i \| IBRlUTICl; BBTalOLISS; BZTaBOlIIES; I \| EOPDUTIOB IIPOSOtE; OBB1I 1BI1S 1 1 f 1.0 eg/kg I Utopjy, 2* kr after deatk, dose I Lev lire. B. 1 indetemiBed. \| rlerro. B.F. 1 1 Coze, S.». 1 53 rr old, 70 kg, dry cleaner, tt. ( Talaatoor. I.e. 1 1 1991 1 VltSIIU; 1D01TS; iOTOPSIES: BIOOD: \| Journal ot Forensic I fB»r«; 5IOIITS: LITBB; LUB6S; \| Sciences 26{1) :206-20« 1 fcinstc BtcicisE; CBIOEIBITED i 1 T9(oc»sBcrs: iiroasmu iccioevrs; t 1 OCCVPITIOMt MZ1BDS; UDDSTBUL \ t CBE'ICILS \| 1 { 0.0 sg/kg 1 lutopsy, 2 kr after death, dose I Lirine, B. I gnl«tenl>ed. \| Plerro, B.f. 1 1 Goza, s.v. 1 53 yr old. 70 kg, dry cleaner, n. 1 falentoar. J.c. 1 I U51 1 incznt; IBOirs: inofsitsi BLOOS; i joaroal ot Tor en sic 1 ItHV; SItltTS; IITE8; 10I6S; \| Sciences 26(11:206-20* \| 'CBMSIC lltlCIB!; CBLOBUWID \| \| EIDBOCUBCIS; HDJSTBIU 1CCIDEETS: 1 1 OCCVMTrolIt niHBS; ITOHSTtHL \| 1 CBJnrciLs \| 1 1 1 1 .0 ag/kg t litopsy. 2* kr after death, dose ( t«ilee, B. 1 nd«ter«ined. \| rlerro, H.r. 1 1 Got. S.I. 1 f3 TT on. 70 kg. dry cleaner, Tl. I T»l«ntoor, J.c. 1 1 »«1 1 iiisiin: >iat,TS: IOTOPSIIS: BLOCK: t joernal of forensic 1 EB»I»; tcnniS; IITEI: must I Sciences 26 (1) : 2 06-20 \| fCBZISIC ------- BttvleM, tetracMoro- (8 CIJ ctaeae, tetncfcloro- (9 CJ> IZ7-M-I C2-CH SI 165.85. BP 121 C (CORIKIED! T.ISSBE 3SS8 Briw EXfOStTBX BOOT! Inhalation 1ULTTIC1L BZWOD Caloriietrr rorasE Of C1SBS 2 SWGE » 1-7. a 19/1 b) 0.3-5 a«/l BE1B a) lot given b) lot given GEIEBll IIFOIBITIOR a) Start of exposure to peak at 10 he. 2.3 aq/1 at 22 hr i) start of exposure to peak at 12-20 ht. (.3 sq/l at 25 nr ]c triehloroacetie acid after eiposure to tetracbloraethvlene vtpors (390 ao/1) orer 6 hr «iti t»o 30-aln brcats. sliainatioa only a fc« percent of dose. ZstiaateA froa graphs. fclntMti TC11I9; UBIIE: lETtBOLISB; CELOBIIITIC ETDBOC1BBOIS er re MICE Bolanovslca, V. Golacka, J. 1»72 Belrcyna Pracr 2C23):109-119; TC-78-0130 eae, trlckloro- (« CI) Itkaae, trickloro- (9 CD 19-ai-6 C2-B-C13 g? 131.«». gc 73 C, B» 87.1 C, It 100 n 8g at 32 C USSHE 3959 Blood 3960 atetth EIWSUBE SOOTI Inhalation Inhalation 1I11ITICK HITHOD GC ac BTFiBES OF C15SS « < sue: a) 0-2.6 09/al 1) 0-1.3 119/mi aj 0-38 pp. b) 0-11 ppa n&i a) lot givea b) lot given a) lot gliren b\| Bot ?i»en 611 HiL IIFOtBJTIOl a) 0 aad E hi after start of 100 ppa for 6 hr. Final valve, 0.2 uq/»l at 2« hr b> 0 and » hr after start of 100 ppi foe C hr plis etaanol pretreataent. final Talae, 0.1 at 21 bl t) 0 aid 5 hr start of 109 ffn for < «t pins ethanol pretreataent. Final valve. < 1 ppa at 2* hr. Ethuol qiven to naintaia blool level of 0.06«. Bstinated fros graph. 20-2« rr old stadents, t 62-77 kg. (ElCBIIIlTED EIDBOCiSBOlS; ilCOHOLIC »T1B1«ES: S100D; 910QD PUSH; T15I1F: BCT1BCLITES; IP!T»BO1ISH; ItTLTS; GESillY BEFEBEIC! f j 1 laller. 6. Spassonski, B. Benschlor. 0. 197S irchives of ToiicoLogy 33:173-189 Holler, C. Snassottaki. 8. Censchler, 9. 1975 archives of Toxicology 33:173-189 OJ Ln (HIT PIS!) ------- fthvleae, trichloro- (8 CI) ttkeae. tclcUoco- J9 CI) 7t-01-« CS-B-C13 S« 131.40, SP 73 C. BP ST.1 C, TP 100 u «g at 32 c (COITIIUBD) I 11SSOJ 3M1 Ireath 3962 Breath 3»«3 Ortse ZIPOSOBI 100 halation etWl IIILTTICU SBTBOD IX 9C OC/BS SC/BS IIBBIB or CISE 4 a 0 tuet a] sot given b\| (at given c] tot given d\| lot gi«« a) (at given fl lot given »ot feteeted-3.9 ngyhr •-22 «j/l BE« \| CI1IBIL IlTOtStTIOI I JEWHMCB 1 1 1 1 1 1 a) 28.7 ppa \| a) 1 ill after 200 ppa, 7.5 hr 1 stevirt, C.D. b) 58.3 pp» \| t) 1 «ti after 200 pps, 7. 5 hr, plus I Bake, C.L. c) 14.2 pp« j ctbaaol { Peterson, J.s. d) 29.3 pp» \| c) 30 tin atter 200 ppi, 7.S kc I 1974 e> 9.9 pp« \| a) 30 ili after 200 pp«, 7.S hr. plus ( trciirei of aol \| I Ithaool doac, 1 qt beer or 90 •! 1 1 o4fca after 5.5 hr of TCE 1 1 1 1 BealthT 19-»6 rr olds f 1 1 I Tasodilatatioe. of saoerficial resaels 1 j < face, cheat, shoalders, tetveea 1 1 xca^olae, peaking at about 30 iln, 1 I »«dinq \>j 0 iln. Lesions not I j accaapaaied tT subjective response, 1 I at changes in blood pressure, 9K0, t 1 etc, iriaalTEts, 501-12 panel. I t t 1 ICIIIS; DZlRHITIS: 9IUTB: DBH« ( 1 inmciioi; ticoHoxs; ceioeifs i I cioisic comcoivs; BIILTB BIZISDS i i i 1 1 0.54 vg/hr I Fievioas expoamre to cosponid. iro 1 Cookie, J.P. 1 ether detail qivea ( Caip, B.J. 1 Cryogenic saapliig techaiqne. 1 Belch, B. B. 1 1 1»7S 1 acalthr nilitarT and ciTilian 1 Ircaive* of 1 eiploreea, V.S. lie Force School of 1 Enrironaeutal Health 1 lerospace ledlctne, ages 23-47 rr. 3 1 30 (2) : 290-21 S 1 siokers. I 1 1 1 CEIZniSi C8IOEIIITZD HTO«OC»BOHS; 1 1 CEIOBHE OBSinC C08MOTDS; I I CEicsoBimms: nvostiE coapoorns: i 1 IBI1TI: ItCOgOLS; TIT IS; «D01TS I 1 1 1 1 0 • or - 5.9 ig/1 \| it trlehlocoethanol (Mtabolite) 1 Perdelllai, t. 1 Data also on solvents In factory air 1 Bragnoae, T. 1 t Pavan. T. 1 letters In shoe fact or T in Italy i »«0 1 I Toxicology and Ipplied 1 DIIIB: 8TDBOC1BBOIS; IPTIBOLITES: \| PSaraacOlogf 53:220-229 I nttT; HDismii inosptrzoss; i 1 HtUSTSIlt ITSICfE; US PO[tUTIO»: \| 1 CCCOP1TTOIII OISEtSES { 1 I U) ------- FthFlew, t,1-dlcUoro- (8 CD I«k«M, M-dichloro- 19 CI) TS-3S- C2-M-C12 II «fi.9«, » -122.1 C, BP 37 C, TP 100 •• B» at 15 C JISSOI 39«» Breath EXPOS! IOSTE tiaimcu nTBOO «vas IOIBES OF C1SK 8 sues »ot detected-13.0 ao/kr mi 1.6 ag/hr esiuii IIFOBHMIOB Previous eiposare to compound, lo ether ietailc aiven Cryoanic saiplin? technique. lealthr "Hilary ud civilian employees. U.S. ale Farce School of lacespacc Xilicina, aq«s 23-4T jr. 3 scoters. EIRZISS; CHLOBU1TEC BTBEOC»EBO»S: CHLOBII1 OI6UIC COKPOnilDS; cBio?oBEii!«is: nnoBi» coiponns; EB!»TB: I1COBOLS: TCT15; IDDITS UFEIZICE Conkle. J.P. Caip, B.J. Velck, B.E. 1975 KrchlTcs of EaTiron«ental Health 30{2):290-MS ItkyleM, l,1-«lcliloto-2,2-bis(p-cliloropbeiijl)- (8 CI) ECIMM, 1,1-(dlekloroetlM«illteM)bls\|a-ckloro- (9 CI) 12-55-9 CK-S8-CH B« 318.02, K 88.• C IISSTJE 39«S lAipose 39(6 liipoae BIKJSUBB «OHT1 IIIITTICIL 8 IT BOD GC ------- Itajlane. 1.t-aicUoro-2.2-bis(p-caloronhearl)- (« d) MBxeae. 1.1-(aicaloroetaeB)li4e»«)bis(-caloro- (9 CI) 7J-55-9 81 318.02. IE 88. « C 1ISSI 3967 idipos 3968 laaioti fluid 3969 Blood 1 3970 Blood EXfoson loot B liUYTICaL BETBOD ae-BC X-K (OSBEB OF CaSSS •> 27 ) 1 Cl 1 SO 25 IS 10 iaiG> •) lot giTea b) lot giten c) lot alien 2-21 ppb •-32 ppb 13-281 fpb 32-325 cpb Mil \| SZIZB1L IIFOBBaTIOl I BEPBBSIC1 I 1 I 1 I 1 a) 11.9 » or - 9.70 \| •) Bospital patients 1 Inon. T. ppi \| b) 13 yr old feaale rfth Yusho \| Ibe, 3. b) 1.C ppa, f«t basis I el •« jr old aale »ith chronic PCS { Takaaatsv, H. O 1. 5 ppa, fat basis \| fot»nl«<} I loki, I. 1 i Him. s. 1 Japan 1 Fajiwara, K. 1 1 1975 I fClTcnORIMin BlPenitS; DDT: 1 rafcooka Sedical Joarna \| lIHCnOBOCTCIOIIMKEi BLOOD PlISBli 1 66(10:610-616 \| lEOniSRS; JIF1I; GlSTBOinSSTIUL I \| SISTI8; PESTICI9ES; IDIPOSf USS0E; 1 I IITZg; KIDIBIS: OBEITVR 1 1 1 10.51 ppb f ao poaitirc apociaaas 1 Sazeaar B.C. Seoaetric I I Sth, T.D. 1 Itegaaat towa, aiailic IB ' 1 Bahajan. P.I. I sociovcoaoaic ler«l and diatary 1 1910 1 tabits. Ho occopatioaal or I International Journal 1 accid«»tal exDosare. I»c!cno», India 1 of EnTicoaaental 1 1 inalitical Cbeaistry I EISTICIDIS; CRIOiniTSD HTDBOC«BBO»S; \| 7:25-251 1 ciionis oieinc COBPOOIOS; ODD: DDE; i I tCT; I«OI»; FBESIHCT; 1BIIOTIC 1 1 HOIS; P11CIIT1 1 I 1 1 1 I ICTle I Deictaann, I.B. 1 \| RacDonali, ».E. I iipoael perscas in th« United states, 1 1977 1 tne Watkeclaads, Sctea( larwl, 1 Ecotoricology and j Japan, USSB, Poland, Garaany, India, j Earironaental Safety I Bolqaria, PakistaB, lastria. \| 1:19-110 1 1 1 Mpoctel cases of hypertension, 1 I elentei seraa cholesterol, abnoraal \| ( IZGs or iapairaent of nearoaascolar I I function after acate exposere to 1 I coabinations of pesticides, bat aost j 1 data shoe nc adverse effects after j 1 Icng-tere occopational exposure. 1 1 1 1 iisr»i»: raiGtKii: GIRBIIT; HTDI»: i r issin; J»P»I: (XTBESLUDS; PIKISTH: i I ICIIID: sDssii: s«E9ii; DIITED i I suns: IDIPCSS TISSUE: BLOOI; BLOOD i 1 EltSU; B1CCD SSIOB; SHT180CITES: I 1 itoirocTTES: mi; nsiit: stntt; i 1 BtltTfl B1Z1BCS: OCCnPITIOBIL BaZtSOS; \| 1 PCPBHTIO« ZIPOSOBE: IFOPllSBS; I 1 PISTICIDIS; CBLOSIBE OBS1IIC \| 1 CCBPODVDS I 1 1 1 1 12.6 * or - 70 ppb 1 a) Coatrols, fall-ten pregnancies t Sanaa, B.C. 57.8 * or - 65.3 I t) Pre-ten cre^aaacias I Siddlgai, B.K.J. pb j c) Spontaneous abortions at less than j Seta, T.D. 163.8 » or - 105.2 1 t w* I Krishna Horti, C.5. b \| 1 Bhargara, i.K. I Bcalthy, non-«xpO9ed, pregnant voaen, 1 Ratty, 0. 1 age 18-32 yr, India. I 19t1 1 \| Journal of analytical 1 11911; aBOBTIOf; IDOLTS; TITUS; \| Toxicology 5:6-9 I tlOCD; PtlCXRl; COBP1B1TITE I \| ITltniTIOBS; CHLOBIHTED \| \| BIDBOC1BBOBS; CBIOBIR OBGIBTC 1 \| CCBPOtJUDS; IISBCTICIDIS; PISTICIDSS; I \| PISTICIOI BESIOOIS; POtHLlTIOll \| \| tlPOSnii PBICBaBCT \| 1 1 u> CO (Bill »aSZ) ------- ItkrlM. 1.1-aickloro-2.2-M«fp-cklOTO«n«Bjrll- (8 cq BCIMM, 1,1<-(dieklorostlMnjlla«M)bls(-eUoro- (* CI) 72-S5-9 C14-18-Cl* I* 318.02. n 88.« C (COITIIOID) tISSBB »71 tood. Lasu 3172 Blood, plasna 3973 Blooi, sens 397% Kidney MOSBBB com IB11YTIC1L I B9BBES •RIOD I OF C1SIS 1 1 1 ) 27 1 b) 17 1 0 37 > d) 1 1 •) 1 1 1 1 1 I 1 1 1 1 • 1 SC \|a) 139 1 b> 175 1 C> 199 1 4) 210 \| 1 1 1 1 I 1 1 1 1 1 1 1 1 OC \| a) 41 1 b) 19 1 c» 50 1 ) 28 1 1 1 1 1 1 1 \| \| 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 \| 1 1 1 1 UKI lot five* lot elves lot «!<• lot aim lot «.l»ea ) 0.8-43.5 ppb b) 0.1-18.5 ppb c) 0.5-7. ppb d) 0.3-9.7 ppb a) 1.2-31 uo/1 b) 9.2-118 «9/l e) 7.1-213 nq/1 d) .i-« uoyl lot applicable HI! \| 611(111, IMOBB1TIOI \| IBFE1EICI 1 1 1 1 1 1 ) 29.1 » or - 10.51 I a) Hospital patients \| Inou. T. ppb I b) Euclated person I Ibe, S. ) 35.6 « or - 22.65 I c) •on-esaciated' persons 1 Takasatsn. B. pb 1 o) 13 yr old tesale with Tasho < lokl. 1. 1 21.9 * or - 15.95 1 •) 2* yr old aala wltk aplnstic 1 Biki. S. pb I aiesie a«d atoaach eaacer I fajlvara, X. 1 13 ppb \| \| 1975 1 180 ppb \| Japao 1 rvkaoka Bcdlcal Journal 1 I 6«(10:610-«16 1 FOITCHLOBIUTP) EIPBIITLS; BET: I I BIHCBtOBOCTCtOBniBB; BLOOD PL»SS1: I 1 BIOEL1SIS; JIP1I; 6tSXBOIITBSTIIU. 1 1 SISTBB; fBSTICIOBS; IDIPOSB IISSO!: I 1 1ITII: 5IDIITS; OBEBTIII 1 1 1 1 1 a) 10.5 ppb \| a) Bural blacks 1 Fiaklaa, J. b) 6.2 ppb \| b» Urban blacks 1 Priastar, L.E. O 2.5 ppb \| e) Ocbaa cancaslaas I Creason, J.P. 4) 3.« ppb \| 4) Ural Caucasians 1 Bauer, T. 1 1 Blnaera, T. 1 urban aal taral residents of SC, [ Bauer, D.I. 1 Infants, cklldcen, adnlts, eUerly. \| 1972 1 j taerlean Journal of 1 SOOTH CUOIII1; 1DD1TS; CB1UHII; \| Public Health I HCIil STODTBSi BLOOD PLaSHl; \| 62(5) : 65-651 I CCHMKITI IttLTJITIOSS; ODD; IBE; \| 1 ICT; BIB1DHIB; PESTICIDES; ( I ECITCBLOIIIITID BIPHCTTIS; IP 1 I toiwreioi; rcoD commtnoi; i 1 PtSTICIDt ilSIBOES; VO?ITUTXOB \| 1 IIPOSVtB; SOilL MtBlS; HKBII UttlS \| 1 1 1 \| a) 6.9 a VI 1 a) General population - continental I Kranthacfcac, B. b) 29 u/1 \| central (ratal) 1 klebic-Kolbah, T. c) 53 af/1 \| t) Ceeeral popnlatioa - continental \| Kralj, a. d) 23 a«/l \| foatk (urban) \| TkalceTlc. 3. Oeoaetric neans \| c) Szposed (erkers - contiaaatal I Beinec, S. 1 aorth («rbu) ' \| 1910 1 9) Exposed vcrkecs - contlaental \ International irchires 1 tootk (arban) \| of Occupational anl 1 1 ZnTironnental Healtk 1 General population, aqea 6-79 yr. I «5:217-220 1 OccipationnllT exposed vorkecs. ages t 1 20-62 TC. IllMlaTla. I 1 I 1 TBtOSUTIl; BLOOD SEBOII; CBLOBII1TSD I 1 BTDBOCIIBOBS; CBLOBIB! OBSUIC \| 1 CO»POO»DS: CtC; DBS; DOT; \| 1 IHlCBLOBOCTCLOBETalE; PISTICIOES; I 1 CCCOP1TIOI1L HITIRDS-. PESTICIDE \| 1 IZSIDOES; POfOliTIOI BXfOSBBI; B1B.1 I 1 IBIHi U8B1I MI1S \| -_..(• \| 1 \| 76 ppa (fat basis) 1 2* JT aid ul* ulth aplutic aienia I Inooa. I. 1 ail stauck cancer t »b«, s. 1 1 Takauatsu, a. 1 Japan 1 Joki, B. 1 t Hikl, S. 1 FCITCHLOBHIT1D BIPBHTLS; DOT; I luliwara, E. 1 BHlCSIOSOCTClOBnill: BLOOD PLISI1; I 1975 1 IIOfLtSIS; JIPII; GtSTBOIBTISTIIlL 1 fukaoka fledical Journal 1 STSTCT; PISTICIOES; IDIPOSE IIS SITS; \| 66(10:610-616 1 1ITIB; KIDIHS: omTOR \| 1 1 (HIT P1GI) U) ------- 1,1-aicsloro-2.2-bis(p-chlorojhenTll- (6 CI) Eenzene, 1,1'-(illcklocoetlieailidena)bis(«-ckloro- (« CI) C1«-B8-C1« CI 318.02, II 88.» C ttSSB 3915 I tier 3»7« Bilk 3»T7 Bilk 1 1 I 397J tin 39T« Bilk sirosoBB 10 estion ~ i IRUYTICll BBTHOD SC-EC SC/BS - •agora or cis 1 10 25 21 2* 45 «S 1M6Z lot applicable •2.0-H18.5 «g/kg (at glT«« 0.935-2«.«06 pp. 0.535-13.407 pp. 0. 535-26. »0« pp. lot given BMf \| 61BIU1 XBF01UTIOB 1 MMBBfCE 1 1 1 1 1 1 ISO ppa (fat basis) I 2* TT old Bale slta aplastlc aseaia 1 mom, I. j aid stanch cancer \| be, s. 1 1 lakaaatsa, 9. 1 Japan \| »oki, ». 1 1 Bikl. S. 1 soiiciuniiiTtD BiPBims: DBTJ i rnll«ara, n. I nntcBioiociaoRnait; BIOOD PMSBI; i WTS I KOPUSSS; J1P1I; 6JSTEOIII1STII11 \| Fvkaoka Mdlcal Joacmal \| STSTIB; PISTICIDES: 1HIP05! USSQI; \| C« (10t«10-C1« I IITEB: KIDIIIS; OHSlCTS \| 1 \| 1TS.T ag/kg ( HctatiB? fetter I Kodrlc-Silt, 8. 1 1 Salt, Z. 1 17-41 re oldi froi Slaronla Protlgca, \| die, S. I loqaalarla. \| 1980 1 1 Pesticide* sonltorlng 1 TIGQStaTti; 11CTJTIOI; BH,Ki \| joaraal 1» CDs 1-2 1 iiotccviaimon; JBBII IBBIS; i < caeiimTiD eroBocassois: catOBiu i 1 oisinc ccapcojos; CRIOHOBHIBBIS; i 1 rci: BUT: BgucEioaocicioHiiuB; i 1 FISTICIOES \| 2130 » or - 150 ppt ( Bilk bank aonota \| Hacrol. J.B. 1 1 Jsqoith, B.T. 1 Callfociia \| 1980 1 1 Vev Sagland Journal a£ 1 CUIfOnil; ten-IS; BHK; 1 HediclM 1 •loiarrironTioi; LICTITIOB; DO:: IDT: i 303 (16) :9»s-9£ I PSSTICIDIS \| 1 1 1 \| 1 B»i«r \| Oaichaan. (.B. 1 1 HacMmald, V.I. 1 tsposcl peraeis in the Onited States, I 1»71 1 tae fetkaclands, s«ede», Israel. t Boot oxieo logy »d I Japan, VSS9, Polaaa, Seriaajr, India, I EnHroBaental safety 1 Balgarla, Pakistan, Kstria. I 1:89-110 1 \| 1 Beported cans of brpertenstcn, I 1 derated serua chalesterol, abnocaal \| 1 lies, or lapalrsent of nenrouscnlat f 1 Inaction fttr acute axposmte to 1 1 coabinatlom of pesticides, but lost I 1 data show no adverse effect! after ( ] lens-tern occupational eiposnre. 1 I insHia: EBtsisri: estsitr; noil; i 1 ISSirt; J»PII; KTRI811BDS: T1KIST1I; t I tciiio; BH5SU; SVEDBI: USHID i 1 ST»TIS; ICIF05E XlSSVii BlOOt: B1OOB \| 1 PUSH; BICCO 3EBOS; ISTTBBOCTTES; \| I IWItOCTTIS; (IIIKJ WRI»I; BETIE1»i \| 1 gitiTB sirtsrs; OOCVMTIOIIL BIZJBDS; i I 5CP011TICK BXPOSOBB; JIOPUSHS; \| 1 PZSTICI9IS; CBLOBIIE OSGaaTC 1 1 CCBPOOirBS I 1 1 «.64g ppa \| «) (oral sctkera, fat basis t Pozo Lora, B. 5.833 ppa \| \) Urban lotkers, fat basis I Berrera Barteache, 1. 6.263 ppa \| c) 111 .others, fat basis \| Polo Tillar, 1.9. 0. 11» ppa 1 d) 111 anthers, nhole ail basis I Lopez-Gltenez, B. 1 Cata for sna of all pesticides and I Jodral Tlllare^o. a. I ccifarisons vith valoas of other 1 Iglesias Perez, J. 1 lirestiaatoti X HE'KS; TTOBal IB? IS I 1 1 (HIT PIGZt ------- Itliylene, 1,1-dlckloro-2,2-bi8(p-cklorophen7l)- (8 CD Eenzcira, 1.1>-(dlckloroetkeoylidene)bis(4-ckloro- (9 CI) 7Z-JJ-9 C14-M-C14 If 318.02. If 88.* C (COITIIIIED) tlSSdl 360 Silk, fat 3481 Oaentai 3982 Placenta 3983 Placenta MOSOSS W30T1 atalTTICaL KETIOD ec-BC GC-EC SC-EC IOBBS3 OF C1SIS 1 50 a) 25 W IS at 10 BUGS ) lot given ) lot givan I lot given ) lot given ) lot given ) lot given lot applicable 37-19 ppb ) 3-42 ppb b) 7-5* ppt C) 7-19S ppb nil \| exiHii iiroiRaTioi 1 1 1 ) 1.71 + or - 0.88 I ») 1972, 40 saaples pa \| b) 1973. 31 saaples > 1.98 + or - 1.51 1 <=) W«. " saaples pa j t) 1975, 20 aaaplas ) 1.9« « or - 1.0» \| «) 197S, 19 sa.ples pa \| f) 1977, 20 naples d) 1.92 * or - 0.79 I ppa \| 100-11 lactatinq voa«n, 2 lonths e) 2.02 or - 0.99 I alter deliTery. Bes Wants of Osaka ppa \| Eca lecture, Japan, varied diets and :1 1.60 » or - 0.6* 1 «n»irometit«l conditions. ppa I I J»P1I; aDDlTSs LkCTlTIOl; BIIK; \| EIOICCUHOliTIO>; PISTICIDIS; DD<; I oi6»ic cmonn COHPOJIDS: \| fOlTCHLOSIIaTID BIPHIIILS 20 ppn (fat basis) 1 «* Tr old >al« »ith stoaach cancer I 1 Japan 1 \| ICLICHlOSHiTID BRBIITIS: DDT; \| BHICHIOBOCICLOHHIIE: BLOOD P1»SB»; \| ItO?tlSBS: JlPaS: CtSTSOIIlZSTIIaL \| STSTBI: PISTIC1BE5; 1DIPOSE US SOT; \| IITIB; HtHlIS; OMIT1JB 1 50.54 ppb \| 31 positive specinens GeoMtric 1 j Ptaqnatt voaen, siailar in I iccloa-coaonic l«>el aafl dietary j babits. lo eccnpational or j accidental eiposnre. t.ac1cno«. India I \| HSTICIDtS: CHlOlIltTIO HIDBCC»BBO«S; I cnoBiii osGinc COIPODIDS; ODD; DIB; I en; noil; PIISIIICT: IHSIOTIC I iinio; ?i»cin» i I a) 11.9 » or - 11. « \| a) Controls, fall-tern pregnancies ppb \| t) Pre-ters pregnancies b) 31.2 » or - 15.0 \| c) Spontaneons abortions at less than ppb \| 8 «tt (inclades fetus) c) 93.6 « or - 69.3 I ppb I Bealtky. non-exposed, preqnant nonen. \| ages 19-32 it. India. 1 \| IIDIa: tBCRTIO: aDOITS; TITOS: 1 110CD; PLlCIRa; COBPlBiTITI \| ITHOlTIOIS: CH101II1TIO \| BYtSOCUtBOlS: CHLOBIK ORCkllC \| CCRfOTKDS; II5ICTICI9ES: ISSIICIDIS; \| fISTICIOI HISIDDES: POPtlLlTIOl \| HPOSOBS: PBIGIilCI 1 BEHBEICZ Takasaiji, T. Vataaabe, I. Knvabara, K. ToshUa, S. Koyaaa, K. Huita, 1. 1»79 International archives of Occupational and Environmental Bealtn »3:1-15 Inoae, T. Abe, s. Takanatsa, B. >okl, I. Biki, s. Fnjiwara, K. 1975 rakuoka Badlcal Journal 66(10:610-616 Saxena. I.e. Setk. T.D. flahalan, P.I. mo International Journal of Environmental analytical cienistry 7:245-251 Saxena, R.c. Siddiqai. B.X.J. setk, T.D. Krishna Rorti, c.s. Ehargava, l.K. Kitty, D. 1981 Journal of analytical Toxicology 5:6-9 ------- flsorlte 1698-8-8 f It! 18.998 1ISSVI 398* Hood. plassa 3985 Blood, Plasaa 39tf Hoot, ser» 87 lie 388 Brill BirOSOlE BOOTS aULRICU BRBOD lagestios ISj Isgestlon lahalatioR Tngestlon colorlMtry ISB ec s •DUES 1 I1I6S \| mi \| GtllBlL IIPOBS1TI01 I 1SFI1BICE or CSM 111 i III 1 III 1 I ») 1«-20 »g/»l \| a) lot give* \| a) tefore vanish application to 1 Ekstrand, J. 1 b) 60-120 ng/nl I b) lot given I t«eta I Koch. G. 1 1 \| t) attar Tarnish application to \| Potersson, L.B. 1 1 I teeth, dose 2.3-5.2 9. peak at 2 hr 1 110 III I Caries Besearch 1 1 1 «-1» Tr olds \| 1«: 185-189 III 1 I i i FtnoMDE: BICOD nasai; CHUDBM: i 1 1 \| Mill: SIIDZI \| iii i 26* \| a) lot gi.ni> I a) S. 00 » or - 0.27* \| a) 10-20 Tr old* \| singer, 1. 1 b) lot given \| oaol/1 1 b) 21-30 Tr olds \| cphaog, I.E. 1 c) lot given ) b) «.7» + or - 0.216 \| c) 31-«0 yr elds I 1979 1 d) lot given i naol/1 1 d) «i-so yr olds I clinical Cnenistry I •) lot given \| c) S. 58 * oc - 0.316 \| «) 51-60 re elda I 25 f«> SS23-S25 1 f) lot given \| nsol/1 \| f) > CO rr old 1 1 1 d) 5.«6 » or - 0.295 \| Ifter consoirtton of fluoridated 1 1 1 naol/1 \| »it«r (1 aa/1) > 1 yr I 1 1 •) S.«7 » or - 0.326 \| \| 1 I oaol/1 I Beside its of n I t 1 f) S.58 * or - 0.32 I I 1 1 naoVl 1 IIIIBSOTI: 1 CHITS; 1GS; CHIICBEI; \| 1 1 1 IIOOD JtlSBJ: C01P1MTITE I 1 1 1 !1U0»TIO»S: FLOOIIEI; DBIIKIR6 «TtI I III 1 1 II 1 " "' 1 • I a) 0.0-0.06 ppa \| a) lot giren { a) Controls \| Obel. ».». IB \| b) 0.01-0.07 pps I b) lot given \| b) laboratori persoBMl, > 20 TI 1 Socenson. S.D. I 9 \|c) 0.01-0.09 pps \| e) lot given \| eiposir \| Roach, D.I. 1 1 1 e\| Frod«etiea vorkers \| 1980 III I Isericaa Industrial 1 1 1 lerkers at aaaoaias \| Hygiene Association 1 1 1 Ferflaorooetasoate prodnctloa plant. I Journal «1:58-589 1 1 1 ftOOSIfl; IIDOSTBIll «ltRS; B100D I 1 1 1 snag: occqpnioiu. BI±»BBS: B»S: i 1 1 1 FlflCBIDl; PlIOBin COSPOOKCS; \| 1 1 1 IIBUSTBIlt HMSPHSBES \| 1 1 1 J 1 1 1 1 1 a) 6.5-18. e ag/1 1 a) 12.02 ag/1 \| a) tofor local exhaust ventilation I white. D.I. 1 b) 0.2-3.2 ag/1 \| b) 1.«1 eg/1 \| b) Ifter ventilation \| 1980 III 1 Joarnal of the Society 1 1 1 Scottish factory workers exposed to 1 of occupational 1 1 1 "- I Bedicine 30:12-1* 1 1 1 SCCTLUB: OBIIE: FL001IDE; mnSTBIU I 1 1 1 aTIOSPBEBES; OCCOPtTIOIU. B1Z1KES I '•I 1 1 1 1 \| 1 a) lot gives 1 a) 100 ng/12 hr I a) Before Tarnish application to \| Ekstrand, J. 1 b) lot given I b) 200 ug/12 hr \| teeth. 2 yomxjer children \| Koch, 6. I c) lot given I c) 5SO ng/12 hr I t) Before varnish application to \| Petersson, l-G, 1 d) lot given 1 i) 1. 100 ag/12 hr I teeth, 2 older children \| i«o 1 1 le) Ifter varnish application, 2 \| Caries Besearch 1 1 1 voisger children \| 1«:185-189 1 1 Id) after vanish application. 2 older I 1 1 1 children \| 1 1 I rose, 2.3-3.0 nq for younger children I 1 1 1 and 5.0-5.2 19 for oiler ones \| III 1 1 1 1 -1* yr olds \| III 1 1 1 1 IIOOBIDE; SLCOO PUS1»; CHXIBEII; \| i i i ciiiz; SIIBZI i - - 1 1 1 1 ------- flierlM 7782-«1-« r Itl 18.99M. op -2I9.«1 C, IF -188.13 C. If 100 mm Hg at -203 C TISSBB 3989 Blood, nPOSOBB MOTE AIAITTICA1 HITBOD ac mass* or CASES at * b\| * O »9 IAI6E a) 0.01-0.08 ppa b) 0.04-2. CO ppa e) 1.00-71.00 ppa mi a) lot given b) Wot glTea ct lot given GEBZBlt IirOBUTIOB a) Coitrols 1) Laboratory personnel, > 20 jx •xpoair* c] Prodictioa tOEkeca forkera at aiaoaloa ptrf luorooctuMatat ptoonetion plant. flOOBIR; IBEDSTlItl PLAITS; 8100D SEBBH; OCCOP1TIOBU, BISABDS; BITS; ItBCBIBB; TLOOBIIE CCSPOOIDS; IIDDSTEIAl UBOSPBISIS tEKBIBCI Ibal, F.I. Socenson, S.D. loach, D.B. 1980 aaerican Industrial Bfgiaae Aasociation Ooarmil »1:58»-5B9 113-39-7 ei-BS-i-o » 59.01, BP iao-ies c 1 ISSUE 3990 VElM 3991 BXIOSVB IODT1 latalatioa Da rial laaalatloa AI1L1TICU BET HOC ec 5C OF CaSXS 22 9 "BGB a) lot airai b) lot given e) lot alien d) lot qlTea 0.«- 19.56 .O/O.T BUI a) 19.9 * or - e ag/g creatiaine b) 63. 0 + or - 16 aq/g creatialae e) 10.3 « or - 5 ag/g creatlniae d) 22.6 * or - 8 ag/g creatiline lot glTea CIIZBA1 IBTOBBITIOI a) Before >otk, 2ad da? t) after wort, 2ad day (expoaare 92. « * or - 21 ag/ctt a « kr c> Before »ort 5tV Jay d) After work Sth dar (expoaare SI. 7 * or - 7 aq/cn a i hr 31-»7 TT old voikera in acrylic fiber factory. icdoaiul. qastric pai». VBiiii anitcmES; EIIGIDB; CCCHPATIOI11 BAZABDS: BEALIB HAZAEDS; H5HSTBIH AtRasmtis; IHBOSTBIAL I11BTS; SJTBtl BADtCALS; IBBAlAItO* 20-29 TT old factory nortera, Japan. I1IBB; 9ITA301ITBS: J1FAI; CCCOPATIO»»1 BAZAB9S; BBA»B HAZABOS; 1IDOSTSIAL AlflOSPHCRES: ZIDVSTfiXAL BHEEtIC! lannerfa, E.B. riTita, A. Biqolet. ». Eanbean, D. Backet, J.S. Roels, E. A. 1990 International ArchiTes of Occapatioul and CDTiroanental Bealtk •5:19-203 Toneaoto, J. SnznU, S. 1980 International Archives of Occ«pational and EaTiroaaeatal Bealtk •6:159-165 U) ------- !oriMi4«, CJ-S7-I-0 B» 73. M. IF -61C. IP 153 C at 760 •• E«. 7C C at 39 » B}, 25 C at 3.7 M Bo. TP 3.T » B« at 25 C IXSSn 3992 trcata I IIMSOJJ SOnil Inhalation lULTIICJL RETROD BC BOBBM OF C1SBS a\| 5 it a C) 7 d) 9 •1 8 a ^ « « h) 5 iiies a) 4.9-2.9 ag/cu b\| 0.4-2.4 ig/cg c) 0.»-2.a lo/co 4) 0.1-2.9 ig/cn •1 0.7-5.1 mg/cu f) 0.7-».9 «g/co 9) 0.7-7.1 cg/ca k) 0.7-.« «9/ca an a) 1.7* ig/cn > b\| 1. t »g/c« • c) 1.27 g/aa • fl 1.5 »g/c« • •) 2.23 g/ca • f) 2.07 iv/eil • 3) 2.( >g/ca • h) 2.3 «9/ca i 6XKML t»ro«mrioi •t 0909 ir b) 1000 kr cl 1100 hr 91 1200 kr «) t0» kr tl tSOO kr 41 1600 kr h\| 1700 kr saifle tlmfs dorlag • kr shift lectots In artificial luttc factory. Italy Hill; tDDLlS; BHaTB: SOLTBWT3: FUBISl HJ1LT1 RAZUDSs K005TEUI JITO3PHMZS; I»B1HIIO»; OCCOPlTIOJil I111IDS unuicB BTtgnoM^ F. Parbcllial. 1. CalCnri, I. IfSO Britlak Journal of Iniustcial HeiiciM 37:1«5-1«» fatal \|tO-00-9 t«-a«-o >1 68.07. RP -8S.6S C, BP 31.3C C I TISSU1 1 1 1 1 3993 1 Breath 1 39«« tr«atk BIVOSHIE ion . _ 1I1LTTIC11 •erioo ec/as GC-BS man or cisss 8 _ 5« (387 saaplvo} Miec lot d«t»ct«d-98.0 g4/hr lot giraa »B»» Giiitit urotBinoi 21.3 <9/ ------- tmllltm 7MO-55-3 c* Itl C9.T2, ft 29-78 C, BP 203 C TTSSm 3995 laic ttttaam earn 1I11TT1C1I SETHOD EOSBSS or USES IMG! "' GrilUL IITOSBITIO1 levin. 2 rei>rese«titl»e pie-anal yds tceataents ace tafcilate. Tbe feasibilltT of a kolistie, no-«ask policy foe kale ••alTsis is ootllmed ad sapjoctei. Kim: TBICI ntRSBts; s»ii; * ------- - (2-setarUe»zo7ll - C10-H11-I-03 (1 193.21 1ISSOI 3»97 oriae tZPOSOlt BODTI Inoestlon laaalatiOD RRB09 BFLC IVIBSS or cisss a) • b) « c\| 2 (IKE a) lot glvaa b) lot gi»«n c\ ff-O. t» sg/sl fUt a) 0.122 » or - 0.00 b) 1.2 « or - 0.4 •g/al c) Mot glma GEBIIll ItPMBaTIO* • ) 2» kr cxcretloa after 0.3«* •ol/kg oral dose of o-rylt»«. Peak IB 3- be t) Ifter 3 ht exposure to 13» pp» c-xTleae vapor. Peek at 3 ar «> Paiatera. Xstlaated fro* orapa. Diiraal variation. volunteer!. Man ages 53 jc (oral) , «« rr ------- 7MO-S7-5 Itl 1»S.»6«5, IF He. 76 C, » 7700 C. W 1 mm Ig at 1M» C, 10 •• Ig «t 21CO C TISSIl 1000 Waej W01 Uar 4002 laag nosns tagti immcu BKBOD n n n nrnra or cisss 8 21 ») e b] 20 4 8 b\| 9 d 11 iiiei < 0.00001-0.0011 ag/g < 0.00001-0.0021 ag/g •t «t \| < 0.000010.0006 »g/g bj < O.OOOCt-0.0010 19/t tat lit •) 0.000080-0.0079 oq/g b) < 0.00002-0.01* og/ij e) 0.00024-t uA teatk 0-1.5 IT \ la fttap I •« 2-19 fc, gto»j II. I cntcols, aqaa «3-72 rr. «ko llnd SO I »i {xoa tb factorr. S««4«n. 1 \| !1!»S»: C1I»Z8S: IIDIITS: tITII; \| IVTCSt CO»»IITIfS mUHIOIS; I iiDosTiiii tieinii nisniEim 1 siTBoes; imsoii: ustiic: CIDIUJB: \| CISIOP1; CnOROl; COtUT: COFPIl; 1 «CLH; iio«; umiuwi: HID: \| I1IMIESI; M1CUIT; ROITBPIim; 1 iTOswoBDS: ivaiBini: SCHDIOB: \| SIIHI35: 5I1TSB; Til: TOISSTII: I IMC; II11T1 IK1SDS; UDOStlUt i tiins; smms; Tmmioa a) lot gi»e» I a) Coatrol* b) lot giia \| I) VoikarB, groaps I aa4 II 1 1 I«c«aaal r«flMcr and a»lt»r I toikcn. »gai SS-7C jt, •z^oced to 1 Icavy actala 1-3 4acad«s. Tiae I tct«a rctlnaaat aa4 teatk 0-1.5 yt I la gcoip I aal 2-19 it, groaj II. j Coatcola> aq«a »3-7J ji, »ho llia SO 1 1 • fcoa tk« tactocr. $••!•>. 1 1 aiuii: ciouns: riwiis: mm 1 IBISS: COWUITITI mtOlTIOlS; 1 imosnm Bteins; msoBtatrr I HIIO9S; niTisoii; iismc: c«Dnra«; I cisn»: craosnii; COBILI: conBS: \| SCID; 1101; IHTBIIOH; LEAD; 1 iMsutsi: iiBcoiT; BonsriftHi: 1 {BOSfBOius: straiDlui: scitiiOR: \| Slltnil: SIITIE; Til; TOIOST5S; I ZIfC; IStlTR BIZISBS: I»D9St8I»L \| tllrtS; SHSITCTS; TIUmiDB 1 a) 0.00062 V)/i \| a> Controls b) 0.0017 ag/g ( t) larkac qrcup I c> 0.0023 og/g 1 e> lacker grnp II nt »t i a»li»os \| tcc«aa4 ccflMcr tai nelt«r 1 lockers, aq«i S5-7S yr. •xpaacA to 1 b«»TT wtaH 1-3 tacaft-. Tiae \| t€tM«H ntlXWMBt U4 3«tk 0-1.5 TC t tn group I and 2-19 TC. gtoap II. I ccatcola, agas »3-72 rr. »1ia lii«l 50 1 k> fraa the f actor?. Svedaa. 1 f SHDZt; ClDtfmS; KIDSnsj 11TES; 1 toiGS: con?»iTin mintTiois: I unnstatn. vtettrc; seisoaiBirr 1 stiBODS; ntHom: IBS me : CIDSITJII: 1 CISIUR: CBSOHWB: COBUT; corpn; 1 eciB: IJOP: I»TIM«I: LJ»D; I 8»Gtnsi: tmcun; ROITBPIIOR: 1 ccosrwngs; BVBIOIHS; sctigioi: I SHEfXIM; SIITEB; TH; TO«SSKIi \| -JIC! a«»lTB BIIJBOS; I1DOSW41 1 flirts; sunnts; TtLi0 Scl««c« of the Total raviroa«t 16:13-15 Bcana, D. locdbeig, G. V«ster, P.O. 1980 Sctoace of tba Total Ia»iro»«»«t 16:11-35 (HIT P16IJ ------- «cia 7440-57-5 In I« 196.9665. HP 1064.76 C. EP 2700 C. TP 1 •• tig at 1869 C, 10 an 89 at 2160 C (COETT.BOED) TISSUE «003 Hall SIFOSHBE BOOM immcii BET BOD » 101 BBS Of OSES a) 9 b) 11 sues a) Wot given b) lot given mi a) 2.64 or - 3.81 PP» b) 0.«2 * or - 0.32 PP» Dry lit GBIEBIL IIFOSBJTIOI a) «oian t) Ben left thiab Use revieved; knovn levels ot 30 other ele««ts Bealtkv 20-60 re olds HOLTS; SCI: IIIIS; BBflM; UDBIIHB; IITIBOII: IBSCTIC; BIHIDB; C1DBIUS; caicni: cisioa: CHBoaing.- COSIIT; ccppra: eiBBiiinB; GOLD; isoi; uig; xensiiiH; Hiieiiisi; RISCOXT; lOlTBDIIBI; RCKBL; fOTJSSIUB: BHBIDI1R: SBlZflOB: SI1ICOII; SILVIB; joetnR: SIBOITIQB; Tt>: TITIIIHH: 1H1DIVJ: ZIK: ZIBCCIIDR BZFSBERCZ Xanabrockl, E.I. Kanabroeki, J.I. Greco, J. Kaplan. E. Oester, T.T. Brat, s. s. GastafsoD, P. S. Kelson, D.I. Boor, C.E. 1979 Sclenctt of the Total E>TiEon»ent 13:131-140 Beptane 142-82-S C7-116 f« 100.20. IP 98.52 C. TP 40 •• Bg at 22.3 C nssra 4004 Breath FIFOSOBI IODTE a»tmci BETROD GC-HS inaaxs or cisis 54 (387 saaples) EIIGI •ot given BUI 1.8 09/1 Geonetric GEIII11 IHfOBBlTIOl Beanceil at 25 c and 760 » Hq 47. 0* occarrcnce lover and upper one-Signa lialta 0.69 and 4.7 nq/1 BealthT. 18-35 ji old, nonsmoking. nrfcan blacks and Caucasians. Chicago, It. Rigidly controlled eipcriaental conditions. I1I1TB; JICOBOLS; I1LIIOIS ; 1DITITS; CEIOBIMTII BTOBOCaBEOIS; 7O11TII.B CfSUlC COBFCOMDSJ HULTH B1Z1BDS; IIH»HTIO»; Brtuonsa; BXTIBOLITES; COPOLtTIO* EIFOSOBi; OBB1I tBElS BETBBEHCZ Krotoszynski. B.K. Brunean, G.H. C'Belll. B.J. 1979 Jovraal of Analytical Toxicology 3:225-234 oo Beptan. 2,4-diaethyl- ;J13-2J-Z CS-B20 (I 128.76, !F 133.5 C tlSSBl 4005 Breath t t \ » EIPOSOBE EOUTI \ I \ \ 1IJIITICIL BETHCD SC-BS 1 I t IDiBIB or cjsss 5« (387 saiples) illGE lot given mi 0.267 ng/1 Ge one trie t I GEBBBli IRrOMlTTOi (•asared at 25 c and 760 •• Bg 46. 5< occurrence lower and upper one-Siga Hails 0.0«S aad 1.5! ag/1 1««lthT, 18-35 jt old, nonaaoltinq. nrtan blacks »d caacasiaas. Cfclcaqo, 11. BiqldlT contcolled • xveriMetal conditions. ISI1TH; klCCBOlS; IlltlOIS; UD1TS; CB105T11TID BT9-BOC1BBOIS: VOIlTItX ctetiic coiifcncs; BEIITB mziBis-. llflllHTOI: BITIB01ISR: BI1WOHTES: tcrnnTTOi ixtosims IBBM uzis PIFEBEHC! KrotosTjnski, B.K. Brnnean, G.I. O'leill, B.J. 1»79 Journal of Ualytieal TOTicologr 3:225-234 ------- , 2,5-diMtari- C«-B2O BI lie. 25, tt 136 c tisstt »00« truth arosast WOTS luimcu BET8OD CC-SS » oasis or ctszs 56 [397 oaipl«s) fl»GE flot givfll Bill 0.083 09/1 Geoaetric SBKBII nroaa»Tio» aeaarea at 25 C »a 740 II B« 21.25 occurrence to»r »3 op par ooe-Sigia Halts 0.019 in a 0.353 Bq/1 BealthT, It- 35 TC oil. noniBOfcia?, «tn black* u4 Caucasian. Chicago, IL. BlgUlr conttollea etpcctMBtat condltioos. ESIHB: 11CCS01S; IIUIOIS; UVLTS; CB101IHTID BIDBOCHBOSS; 1014TILE CBGIITC COBfCDUDS: BI1I.IB BIII8CS: IHIHTIOI; IRtBOlXSI; RITtBDIrrES; tCTDtlTtQI tlPOSDM: VSBK 1BUS sxtttstcs tratoazjncti, I.E. Broi«»f S.B. O'lteiH, B.J. 197 Journal of In&lTtic&l ToiicologT 3:225-23* S«ptrl alcebel (a CI) 1-M;tuol (S CI\| 111-70-* C1-H1«-0 II 116.2. » -3».6 C. BE 175.8 C. TP 1 •• Bol ci»ill«li erplofeea, n.s. lit Torce Sctool of l«rosp«c« fledlclnev a^«s 23-7 rr. 3 stokers. tllZEBIS: CIlQSIflLltl STDECCKBOSS: CE10BI1! OBOinC COBCOraSS; CElOSamtEIIS; FLDOEIK COHIO11BS: fEUTB; II-CCIOL5! TEHS: 1DOITS BEFZBEICE Coakle, J.?. Caap. B.J. nelch, B.E. 1975 •rcoiTes of Eavlronaental Bealta 3 0(2): 2 90-295 f 1 (SHI P1GZ) ------- ICXtM 110-S4-3 CC-11 B1 86.17. BF «8.7 C. T* 100 •• Bo. at IS. 8 C TISSUE 400* £t««th trrina siposoB! BOOI I»kalatio» Bataal 1 ZURICH 9STHOD ec-ss ec/as BOBISB or cisis 5* (387 saiplas} 10 HISS Krt »1T« a) 0.1-1.4 ««yi b) 2. 9-30. C •»/! c} 9.7-5.5 »o/l 4) 1.7- 17. S aj/1 SBl» t.7 a 9/1 6a>oaetrlc a) 0.5 * or - 0.4 •«X1 b) 10.1 « er - 8.3 •9X1 c) 2.4 » or - t.7 •4X1 1) 5.2 » or - «.e •aXl SZBZZIL lirOIBITIOl e«i»ar«d at 25 C aid 7«0 as Rg 6.9% occttic^Bca laiar ii »?Fr oM-Slaaa Haiti 1.63 a«< 13.5 aq/1 B«altkr. 18-3$ rr ol£, aonsaokiiiq. ntln blacks and Caucasians. Caicaqa, II. SioldlT coatrollei «xp«riMatal conditions. ESI1TH; HCOBOLS; 11LHOIS; IDB1T5: CKClIHIfO etDBOClBBOIS; TOIITHE cieinc coapctjiDs: BIIITB BITIBCS; JiaiuTioi; miBoiisa: MTIBOLITBS: IC?BUtTOB ElPOSOIt! UBBI* UZtS a) Is 2-baxanl tt Is 2,5-b«zan«aloa« c) Is qaaaa-Talerolactow S) Is 2,5-Uatk}lfaraa 9«tabolltai lata alia aa animate In factory air letters in ikoa factory in Italy aaizfc: ITCIOCIZBOS; BZIIBOLITIS; Ilitt; IIDOSnill tTMSMEBES: ncosnm treizzt: us roiLmoi; occvrnioui DISUSES nntEicz KcatoazjuliU B.K. BCQIMail, Q.S. 0'Walll, B.J. 1»7* Journal of laalytical Toilcolwjy 3:225-23* Petballlnl, L. Pa»a», I. 19AO Toxiooloqr and Ipplled Pbaraacologr 53:229-229 Kxan, 1-ctloro- •M-10-S C6-BTJ-C1 II 120.62, a* -«* C, tt 13* C r TISSUE «011 B»atn zirosmi IOBT? mtnicii. BETROD SC-BS •mm or CISES S« (387 saapl«s) IIGI •at gi« BUB 0.121 ag/1 Geoiatrlc «ZBI»L IITOtaiTIOI e«a««ra4 at 25 c aid 7«0 aa 89 27. ?% oeeatrcne* lc««r aai app«i: oie-Sl^M 11 alt a 0.033 aad 0.«34 a.j/1 IcalthT. 18-35 rr aid, aonsaotiag. •Tta« blacks u4 cagcaslan. Ckieago, It. Maiair-coatrolled •x\|:ccia«Btal conilltloas. HEITR; ilCCBOtS; HLIIOIS; JOBtTS; CKOSIUT10 ITOIIOCIBBOSS; tOUTILE cs-:irrc cospcoiDS; RZILTI BIIISOS; niitnic: «ET»EOLrs»: SEWBOI.ITBS: POPOHTIOI {IVOSKSS: tIBBaB IBZIS SBrfgEJCI Frotossreskl, B.K. Bra«a««, G.a. O'Mlll, B.J. 1979 .loiraal of Inalytlcal loxlcologr 3:225-23* ------- (nan. 2,3-«Mtarl- ;««-«-! cf-in Bf lit.23, Bf 116 C, TV 10 •• Hg «t 9.9 C TIS5BI •012 Bnatt BMosnE xoni 1IURIU1 8ETICB K-BS •MB!t 01 CUBS 5» O7 caaples) MKI •Ot giT«» mi . 1.« •«/! Sooaetric CEIIBlt IIFOtBlTIOl Bcamrad at 25 C and 760 •• Hg 31. 81 occittcncr lever ul tppar ona-sLgaa litita 0.57 ami a. 5 »q/l MaUkT. «-35 Tc old. nou«oki»). •ct« blacka ua CMcaslaas. Oileaqo, n.. Slqldlr controll«J «ip«rl««»t»l coo4ltio»s. HIKH; IICOBOIS; IUIWOIS: U01TS: c«io»i»«m «n>ociw>is: rautns ciemc coBfcoiBS; anna snitos: initmoi: IRIMLISI; Bnimms; rOMUIIOl IIMSOKE; 0«B»« 11E1S BirESZRCE KrotosifiMki, B.K. Sraneai, C.H. O'Ksill. B.J. 1979 Jamal of lulTtlcal Toiicoloqr 3:2SS-23» IciaM, ].3.S-trlMtkTl- ice«-53-a e»-B2o II 128.1!, BP -1JT.8 C. BP 131.34 C 1ISSBC Bctatk EsnsiBB toon auirncu. BETVCD 8C-BS B0BBH or cisis 54 (387 •uples) SU6E lot gl»«a BEil \| MOM trie eniui uroBBnioi Manc4 at 25 C and 7(0 •• Bq SI. If occirtem t,o««E wd «ppr oa-sia»a limits 1.7 aad a, a aq/l ' MaitsT. 18-35 yc aU, nomaoklag. artaa black and caveasiau. Ckicaqo, IL. Rlqidlr coattollad aipniMital coidltioas. tlllTB: ILCOWLSJ I III SOTS; UV1TS; CBlWltti jp nioVOClBMIS ; TOL&TZLS CKMK coifcmres; BULTI aunts; IIBltMIOl) 8BT1EOIISR: K11BOLITIS: ictvuTioB iiposani; DBBM »Bts BBf»«HCI ~~ Krotoszyncki, B.K. Bruwaa, S.B. C'Halll, B.J. 1979 Joanal of laalytical Toiioolojf 3:225-234 9li«M. 3,a-dlMtkrl- 583-W-x cf-ne 1HSBI 1 «01» Braatk ITKISDK BOOK tlUTtlCU. HCTBOD «C-RS IOI1II or ctsss 54 (387 savplfed) IIIGI lot glTci BEH 3.7 a a/1 Geometric GUtllL IiraUTIOl (caeared it 25 C aad 760 la Bj 43.2^ oecvrrcnce ivme aal appar out-siqaa llaita 1.7 a«l 7.4 iq/1 BealtkT, 18-3S Tr oil, Bonaaoklng, or tan blacka a»d caacaslaaa. Chicago, It. Uoiair contiolled eipariceatal conditions. null: iiccEois; IILIIOIS; wuits: CilOBlaiTID m>BOCllB01S; lOIJ'It! cteiitc codtCTiiBS: HEII-H BIUEDS; iimnTioi; imioiisi!: BSTIBOLITIS; KPVUIIOI EIPOSOK; VIBtl alMS MTttMCB Brncaa, G.a! O'leill. B.a. 1979 Joaraal of analytical Totlcoloqy 3:22S-234 ------- 252M-93-1 ee-«i2 •I M.1S. IP -139.9 C, BP Sa.5 C. TP 314 •• Hg at 38 C TISSJ1 S015 Breath HPOSqES BOTIIB IIIITTICIL BETgOD oc/ss BUHESB OF CaSBS 8 I1IGS lot detected- 1.3 ng/kr BEH O.S «g/-hr eiizFii I»FOSBHIO» Ccapoml fres tmfcaovit origin. lo ether Ja tails giren Cryogenic saapllaq technique. B«althf silitary an! ciyiliao eaployees, D.S. lir Focce School o£ l«rospac« Heflicioe, ages 23-47 yr. 3 siokera. BHIH'SS; CBIOBIIITtD BIDBOC1EBOSS : CBLOaHI OBGIIIC COWOOSD5; CHLOBOEjrZIUJS; FLVQBIRE COBPOUICDS; E1I1TB; HOOBOtS; THIS; 1BOLIS I 1 EiriBEICS Conkle, J.P. Caap, E.J. »alch. B.E. 1975 Irchives of E3Tiroa«ental Bealth. 30r2)s2SO-295 . 1 1 Blppmlc ci« (S CI\| cr> CS-M-l-03 II 179.17. BP 187-188 C TISSUE »016 ntlna I EIPOSOSE BO Oil I.halatlon 1 I 1 1 njirricii HITBOD HflC (OH BSE OF C1SI5 2 BlIGE 0.42-0.46 ig/ml 9E1> Rot qirex GEIIEIL moMlTIOil Cccapatiosallr ezposea to o-rrlene. Dliraal farlatlaa. istliatei fro a naph Kilters, lean age 32 yr mm; arriBOLiTES; occwuioiti HIIiEDS; POP011TIOI tlPOSOBE; BETBTt, EIDICilS; PURS; MB1UIIOI 1 ElFItErCE Ogata, I. Yaaazalti T. Sugikara. K. Shlaada, I. gegaio, T. 1910 Interaational Ircbires of oocapational aa4 EBTico»ental Sealtb •6:127-13* tlpplrlc acid, i-Mthfl- (S CIl ClTclM, I-(3-««tbrUw»OTl)- (4 CI) C10-I1T-I-03 CI 193. 2 T tissn •917 Brine IZFOSD1B BOOT! Ineastion Initiation lUlRicu 9ETHC9 OF 1C »5BBES OF CUBS al • « 2 EJIGI a) tot glwem b) 0.01-0.33 ng/nl "" a) 0.200 t or - 0.007 aiol/kg b) lot oiTea GBItm n-OMHXtW al 28 he «rcrtions alter 0.3S8 nrl/kq oral dose of i-irlen«. Peak IB 1-3 »r t) Painters. Estiaatea froi graph. IJnnal rarittlet. (olinteers, eaa age S3 re (oral) and 32 fr (spray painters) . iBiit; annciiTES: OCCTPITIOIIL EITISBS; TO?DUTIO> BIPOSUB!; BITBTI IC»IS; Fi ! laKOS SBTEKICI Ogata, B. Taaazaki, I. Saaihara, E. Shiaada. I. KoyvfOf 7* 199(1 International archives of occupational anj Invironkeatal Bealth •6:127-139 ------- «ae ft CI\| (9 cii »!-T3-S C«-BS •I tlC.2. n -1.IC, IP 112 C, W 10 U •• at 58.5 C iissie uw tceath «019 Breath MMSOM MITI alURICtl IRIOD CC/BS sc-ss I-DBBEB or cisss s M (Ml naples) MM! lot ------- ladlaa In It* 1U.7C, t* 1SC.C1 C, 3P 20(0 C (COIIIIOBD) IISSOE «02f Brill •022 Mart •023 Eidaer IXMSOIB SOU IMtTTICU BETHOD U u 1 mtn* or cisis > « b» 2 ) 7 » 2 IIIGI «) fat glrm b) tone detected c) lot alten d) lot firen «} tfot gives b) lane detected I lot given i lone detected »S»B \| GZBIUl IirOBBlTIOI 1 I 1 a) 9.OJ « or - O.fl« \| et irt \| •) «ale (1«ll«n) \| t) resales b) lose detected I 1 Icoa a «roep of 1 autopsies. I (oreaslc aedieal ezailnations, Japan. I tales, aean aoe 40.4 re. resales. I aeaa aoa 37. re. 1 I TIICE E1ER1ITS; lUTOfSIIS: J1P1I; 1 iiDnrai: iismc: ciDBiira: COBU.T: I CEBOUIB1: COIFZR; 1BOM; BIBCB8T; I iiciis; siGHisnru; UHGIIZSE; 1 EOBIDHHJ ini!fOIT; SClIDIOTi 1 SlinUMi (TTtllOa; TtJtDIOS; ZIIC; 1 GC10; B10BI1I; LIT1B; (30BZTS; 1 CIBmOI; CIIEBEUgil; B!»1T; BOSCLIS; 1 PlICBtlS; SPlEIi; lUKS: 1OBT1; f BETais; coiipasann EriLnirioss; sii; 1 FCBEIStC B'DICIII t 1 t 0.93 * or - 0.06 I a) tales g/g (vet «t) 1 t) Feule* ) ton* detected I 1 fios a Troop of 61 antopsies. 1 forensic •edical eiaalnatioas, Japan. 1 Bales, nan aqe ««. 6 rr. resales. 1 seen aqe 37.* re* 1 I iiaci ELEdins: ioTopsi»s: Jisu; i iinBZfoi; lESEfic: CIDKOH: COBILT: r CHBosni: cctPiRi IBO»: BEBCOBT; 1 1IEIOB: RaGilSIDIi BalGaiESE; 1 BDEIDIM: 1III90II: SCalOIIi: i stums; nnnm: ntmns ?i»c; 1 BCtD; 3SOB1I!; I1TCT; KIBIXTS; 1 CISIMdS; CESIEELHIKi BtlST; ROSCIES; 1 PiiCBEis; SFISI»: mss: IOBTI: 1 BIT USt COOPIE1TITE ITllniTICHS: S!I; 1 rcizisic Bieicim BTTEBBICB Tatara, 1. Sazaki-Tasnaoto, B. Isaoo. K. Tecal. B. i»ao trchiTes of EiTlrotBental a«alti 35 (1) : 36-an Takasa, Jl. soztlii-Tamioto, g. Isaac, K. Tecal, (1. 19SO irchlres of tnrlronaeotal Health 35<1)s 36-0 'okava, 9. Saiafci-Iasaaoto, a. Isaao, K. Teral, R. 980 rchlTes of nrironaestal Health S(T):36-M (•BIT fa«C) ------- 7«0-7«-S lit 11.?(. 0 156,61 C. BP 2080 C (COITIVIBD) HSSDE »02« line «02S 026 BiBda ZPOSOM 1OOTI ininicit BETROD a M U Brain or cists 11 3 al 2 bl 2 a) « M « inei 0.13 «j/9 (KM ft} 0.005 mo/9 («at «t\| a) Bot 9Lv«n b) Bon lataetaa a) Bat ait« b) Bat fltan SEIB \| OZIIttl XffOHiTIOB 1 1 - 1 ) 0.03 t or - 0.0* I •) Bilas 9/9 fvat vt) 1 t) YavaLai 1 0.00* vg/9 »at rt t Badiaa) \| ?roa a araii of 61 aatopslaa. 1 total lie Mdleal araalnatloaa, Japan. 1 Balw. nil aqe 0.6 rr. (••ales. 1 Mas aq« 37. re. 1 THICI tiRBiitS: lottusies: JIPII: 1 llOBIBm; 1BSEBIC; C1DBXITB; COBll; l cnoEin; corpEB; iBoi: BEKOBT: 1 tBinfl: "WiESina: BueiBESE: 1 BBBioxra; amson; scairemi; I !ItE»TBlJ TIlaBIOB: nBIDTOB: ZIBC; \| 6CLD: SBoniZ; LITtB; KIBfllS; \| CttEB»m; CHffllLWRt HEIMJ BOSCltS-. I tiBCBits; sritiBi toias: icni: \| BtTalS: COBtlBallTB BTalgiTIOBS; SEX; I IOSIISIC BIB KIBE 1 1 at 0.07 « oc - 0.10 \| a) Balas B9/9 (vat vt) \| \) Vaaalav )\| Bon tetacttd 1 1 Ito» a qcoap of tl latopalai. I fcraaslc aaalcal •laaioatloai, Japai. I (alas, aaaa 14* »O.S rr. males. 1 i«ai &9« 37.1 Tr. 1 \| tllCt IlBt«S: IBtOPSIES; JaPIBt l itoBini: iBssiic: CIOBIDB; COBU.T: t CnOHIOBi CCPFBB; tlOB; HEBCUSI; l lit JOB; ai«BESV»: BIIGIIESE: \| J5BIOW1J IBTIBOBT: SCUDIOBl I snniBB: TiniinB! nuDioa: znc; I GciB: BBOaiBt: UTEI; BTDBITS; f ciBEBRira: CIBESEUOB: BUBI; BOSCIBSS 1 IIICIE1S: SI1BBB; tOBSS: lOBTit l amis; coflniiTiTE ETU.OITIOIS: SM-, 1 ICItBSIC BBtlCIWS 1 1 a) Bat aatactad t a) Balat b) 0.02 or - .0* \| t) r«ial«« aq/4 (vat vt) \| 1 Froi a O.EOIT of 61 iitopia«. 1 (oraislc ia4ieal •laainatloa. Japai. 1 BtlM, Mia 19* 0. 6 ir. Taaala, 1 l«a« aqa 37.* Tr. 1 l mci iLBiiits; mopsiss: JUIB: 1 atHBtni; 1BSEBIC; C1D8HJB; COBUTi 1 CB1CBTOB; CCPPiB) IBOB; BMCVBt: 1 11C1OT; BlSBISHIBi BII61BMB; 1 1BBIOIIIB: tlTIIOBtJ SCIBDIVB; 1 siirirafl: TKiitoii TIBUIOB: irtc: 1 «015: KOHni; im«; KIOiIIS; 1 CtlEBtUl; CHZBXILOB: BEaBTJ BUSCLBS; 1 t»C9EU! stinij inias; IOBTI; 1 BITUS; COBPUlTin ETallHtlCBS: SEX; 1 ictnsic nciciBi 1 UIZ1IBCI Tafcana, B. Sazokl-Tanaoto, a. liaao. It. Tacal. B. 1990 ircklfea of inriroacantal Baaltk ( l»3 «» Tnltava* H. Satakl-Iaaaaoto. B. laaao, I. Taral, B. I960 irohirai of EnflroBBBital Ha«lt» 3Sf 11 136-4* Tvkava. B. Svnkl-Timaota. ------- 7««fl-7a-6 III Itl 1K.76. IP 156.61 C. BF 2080 C (COBTIR0ED) IISSOE »027 Pancreas •028 spleen EIPOSOBE BOOT liaiTTICAl RETHOD 11 11 BOBBIE OF CISSS a) S b) 2 a) 5 b) 3 Si BSE a) lot given b) Bot given a) lot given b) lot given BEAR \| GEEtBAL IEFOSR1TXOB 1 I a) 0.01 + or - 0.01 I a) Bales ug/g (vet vt) I t\| Fenales b) 0.002 ag/g vet vt I (aedian) I from a group of 61 autopsies. I forensic aedlcal exaainatioas. Japan. j Bales, aean age »0. 6 vr. Fenales. I neaa age 37.* yr. 1 \| 1P.1CE EISBSBTS: AUTOPSIES; JAPAB; \| AlOBIRVR; 1BSEBIC: CADRIDB; COBILT; I CBBCRIVR: COPPEB; IBOf; BEBCaBT; \| IICIBB; RIGBESIUR; RABGAEESE; 1 SOBIDIUR: 1BTIROBT; SC1BDIDB; I jiLEiim: TITIBIOR; WRADIBB: ZIBC; \| GCID: BROHIREJ 1ITES; KIDBETS; I CIBEBBUR; CE8EBE1I8B; HEIST; RUSCLES; I PIBCSEtS; SPIEEB; LUEGS; AOBTA: \| BFTUS; CORPABATXTE STALHATIOES; SET; \| 10BEBSIC REDICIBE 1 a) 0.01 « or - 0.01 \| a) Rales ag/g (vet vt) \| t) Pennies b) 0.03 * or - 0.03 I ag/g (vet vt) 1 Frov a grosp of SI autopsies. 1 forensic •epical ezaslnations, Japan. I Bales, nean age 40. 6 yr. Fenales, I scan age 37.* vr. 1 I IBACB ELEBERTS; AUTOPSIES; J1P1B; I 1IBEIE1R; IBSEBIC; CIDSIOH; COBUT; \| CEBCHni: CCPPEB; IBOI: HEBCOBT; I IVBIOR; BISRESIOB; RIBGIBESE; I BQStDTIlI; 1BTIBOBT; SC1BSTDR; 1 SIlIBIUd; TIUBIOM; VlBiDIOB; ZIVC; I GC1B; BSORIBt; LITEB; KIDIETS: \| CIBIBBIS; CIBEBElLItH: HBMT; MtJSCllS; \| P1BCBE1S; SPIEEB; IOBGS; aOBTt: I RIT1LS; COHPIStTITE ETlttUIIOIS; SEI; I IC8EBSIC BBDICIBE I BEFEBEBCS Tokava. fli Saznki-Iasaaoto, a. Inano, K. Terai. B. 1980 archives of Environmental Health 35(1):36-«» Takava, R. SaTOki-Iasoaoto, B. aaaao, K. Terai. B. 1980 archives of Environmental Health 35(1):3«-«« ledine 7553-56-2 I Itv 126.90«S, HP 113.60 C. BP 185.2* C, TP (solid) 0.03 aa Bg at 0 C. 0.305 an Bg at 25 C, 2.151 a* Bg at SO C, 2C.T« mm Bg at 90 C TISSUE •029 Rair EIPOSOBE BOOTE 1 IMLTTICit RETHOD BUBBSB OF CASES 1 BUGS 1 sei* GEREBil IBFOBBITIOB Beviev. 2* cepresentative pie-analysis treatments are tatalate. The feasibility of a be list ic, no-vash policy for hair analysis is cutlinei an! sapcorted. EtTIIB; TBACt EIERSBTS; RAIB; • OSIBatll: RUSDBEREBT 1ETBODS; ftTlLS; PBOTZIBS; COBP1BJTIT! IT»101TIO«S; ILORIBTR; 1BTIBCBT; aBSEBIC; BHHIU3: BRONB!; CiDBIUB; CI1CN9; CBICEIBE; CHBONIUH: COEILT: CCPPEB: sail inn: Grsiisinn; soio; ICDIIE: tpoi: LIITHASIS: IZ»D: RisBESiaR: RinaaRESE; REBcniT: BOITBDEIOH: HCKEL: PROSPBOBOS; PCTtSSIIB: BOBID11B: SEtEBIOR; SIIICO«: SILTEP; SODI1": STBOBTIOR; seiftnt: Tils TiriittiiR: TOBOMER; BXFESZBCE Chittlebomigh. G. 1980 Science of the Total Environment 1«:53-7S (HIT PIG!) ------- :«J-S6-2 tt 126.9045, IP 113.60 C, 91 15.2 C, TP [oolld) 0.03 •• Kg at 0 C, 0.30S •• flg tt 25 C, 2.154 aa Sg tt 50 C, 26.71 aa Rg tt 90 c TX3SVS 4030 lair 4031 Balr Eitasora >oni IMtRIClt BXTBOB 11 n ROB an OT CkSIS a) 19 W 15 c) 17 •) 12 f) 5 a) 42 b) 40 B1BGI a) lot glT«a b) lot giTCB c) lot glTaa 4) lot giv«B •) lot gi»an ) lot givan a) 0.059-1.055 «g/g b) 0.015-15.167 og/g Silt \ 61III1L IirORBlTXOf 1 1 1 a) 19.0 or - 5.1 1 «1 Coatrola, at birth og/g \| bl Fnll-tara lo» birth wight, at bt 110.0 » or - 44 \| tlrth og/g \| «) fra-tara, at birth c) 110.0 * or - 49.2 I 4) Coitrola, 1 BO ng/g \| a) Fall-tarB lov birthvaigfat* 1 ao 0) 28.5 » or - 26.1 1 I) Pwtara. 1 ao og/o; I lailtis * or - SK a1 112.5 + or - 44.1 \| ag/g i laaaataa in Balifai. pra-tara group «) 575.0 » or - 113.2 I MM bicthaaight 181« g, 26-36 »lt ag/g \| gaatatioB. foil-tan lo* blrthwaight I gtoap tean blrtk valght 2371 g, 39-42 i »* gestation, ant fall-tera controls j aaaa birtkvalght 3590 g, 38-42 n)t 1 1 BUB: RKits: ziic: COPPIB; I Biieuist: TIUDIUH: IODIBE: nnirs; I s«x I a) 0.422 ag/g t t) Controls b) 0.143 ag/g \| b) Raltlpla celaroals pttlaata Railans I Staples fcoa 7 scalp altaa IB «ach 1 iab]aet. 1 1 Cllllla; ICTUS; CERTMl USTOtJS 1 !1S11lth Tarioos raaal Uaaaaas, tafora 41alfaia ChlUraa, 5.5-18 rr iioiEscERs; cnioan; Kititn tlSUSK-. B1OOD: QBln; HIUOEIH.TS1S; lUSDlHEn RRRODS; I10B; HRUS 1ERBZICC Tnkava, R. Siizaki-Taaaaoto, B. laano, R. Taral, B. 1980 Itchivas of Eivironaaatal Raalth 35 (lit 36-44 Ellis, D. 1979 Clinical Cheaiatcr 25 Pit 74 1-744 flER P1SE> ------- atl 55.87, se 1535 c (para). 1000-1300 C (east). 1SOO C (nought). 1300 C (steel) , B» 3000 C. T 1 u Bg at 1787 c. (COBflBttBS) 10 •• «g «t 200 c 1ISSBB •03 ElOOd. serua 1035 Blood, sens •036 lood. Sana «037 BodT EirosBBi BOBT ingest ioa gestion 1U1RIC11 antes us dioaetry •OBBBI OF casis al 26 bl 2S c) 25 4) 20 10 * ( g 25 12 \| S1IGB ) lot gl> b) lot giea c) lot give* d) lot give a •) «-18 OBOlaS/1 b) 3-15 aaoles/1 212-237 «g/dl 0.2-2. 8V of doss 0.6-1.5* of dose 0.4-12. rt of lose 1.2-8.51 of dose nil I etttui iBToBBitroB t BEFEBIBCB 1 i i i a) 88 « or - 37 I •) Breast >llk OBIT 1 Picclano, B.F. ag/100 ml \| t) Fe-fortizied foraola (1* sg/gt) to 1 Deer ing. B.B. b) 75 » or - 2« \| * 10 I 1980 •4/100 ml \| c) to-fortified foc»la (1« «g/qt) to I tnrlcu Journal of O 9» « or - «3 \| 12 «o \| Clinical In tr it ion ag/100 al 1 d) Ioa-tortiftd focaula (1. ig/gt) I 33:76-753 1) 60 or - 29 \| tc » ao (differed sianificaatlr) 1 ag/100 al I * traasfacria satacation of fe) and d) 1 I •loalficaatlT lover. Data available I I fer ages 3 and 9 ao. 1 1 1 \| Full-tera 5.5-6.0 kg iafaata in 1 \| Illinois 1 \| le Set ieieacT la 2 cases. I 1 1 1 isoi: DIETS: niBoii: luiiois: BIOOD i \| SZBVR; COHP111TITE ETJI01TIOIS; I \| I1CI1TIOI 1 1 ' a) 11.5 aaoles/1 I a) Subjects aith noraal s«rua 1 Watson, v.s. b) 9.5 uaoles/1 1 ferritin 1 Rone, B. j b) Sablects sitk sabaoraal serua I Boore, B.B. I f«rritia I 1980 I I tancet 2(8118) :236-237 1 35-70 jr alia. United Ungdoa. 9 I \| patients vith chronic blood loss* I 1 besipatesis, or i«nes»ctio» for 1 j secoadarT polrcythenia* 1 nornal \| \| klcod iooor. I 1 1 1 DiiTED msoca: BLOOD SIBVB; BOUT; i \| BIOlCCOjnilTIOE; HETIBOLISB; IB TITO 1 I imrsis; IBCI; IEID i 1 1 221 ug/dl 1 Ittkritis patieats vita possibl* iron I B'Seffar, 1. 1 ttorage disease. j ronasier, T.L. 1 \| rox. I.B. \| 38-!> rr old Canadians I 1977 1 f Journal of the iaerican 1 Jcint pain, cltrated transferrla I Hedical lasociation I allocation, aneaia, deer east d libido, I 238 (17) : 1825-1828 1 iipoteace. i 1 1 1 reposition of heansiderin IB 1 1 lepatocrtes IB all, cirrhosis in one. 1 1 1 1 EIOOD sBna: itoi: CIHDI; icniTS; i \| SITUS: BETH POISOII1S 1 i i 1 1 > 0.71 of dose I a) ferric ortnophosphate 1 Bios, E. 1.0 of dose j b) Sod la a irca pyropbosphate j Hanter, B.E. 2.7% of dosa \| e) Ferrous sulfate 1 Cook, J.D. a.o* of dose 1 d) Bedaced iron, 5-10 u particle size 1 Saith, l.j. s«oa«trie I t* suppleaeit foras IB a)-d) 1 Finch, C.I. I « hole- bod T attake 10 days after last I 1975 I of flv« 10 g feedings of cereal 1 Pediatrics I containing 5 g P«- label led dose. 1 55 (5) :686-«93 1 Cata for other iroa nnpleaeats. 1 1 1 I 1-7 aoaths elds, lov socioeconoaic 1 I class, siailar iron nutrition. I 1 1 I ISOI; IMltS; DIFtS: CO<1PlttITt 1 1 TtimiTioiiS: urirts; BOOT: EBDGS; I \| IKCt EIBHEIIS \| 1 1 tiBtt MSB) oo ------- lit* 7«9-89-6 It Itl 35.97, 0 IBS c (pint, tMO-1300 C (cut), 1500 C (troagkt). 1300 C lc >4ieal aiMlaatiODi. Japaa. j (»«t irt) I Halts, M«i aq» »0. « yr. ?«al«, 1 I •» a9 11. » TT. 1 < I t met zuniTSi inomss; J»PII: I t auniWi iismc; ciBBUjB: COBU.T: I i cttoimis; COEPZB: IMC BIBCOTI; 1 i mm: itsitsniB: iiieiiist: i i loeiDimi: imnon: sctnini: 1 i SHUTS!; Tiiunai; mtviaa: »K: \| \| SC1D; nOBIIl; IITHS KIDfFTS; 1 \ cniBitM: cuamm; BUST; gosciis; I i fiicitis; spine inras; IOITI: 1 \| BITllS; COHPlMtm BTiiniTICIS; SBI: 1 i retnsie IIDICIH 1 1 a) lot giv« \| a) 13.9 * ot - 1.1 t a) Global paUltos. 11 saiplcs, b) lot 9iT«m \| ••oVg 1 cMffleliBt of variation (C») 2C.6« e) lot «i»«a I b) 12.8 * or - 0.7 I b) Camlat* n«cl««s, 11 maptes, CT i) lot ji»am \| aaol/4 1 11. « •} lot git«» \| el 10.9 t 01 - 1.2 Icl tataaaa, 12 »a»plas. CT 38.81 IJ lot givaa I uol/g I i) Sabataatia ni^ra, « aaaplea, CT 1 1) 19.1 or - 2.1 1 21.2V 1 aaol/g \| c) Carabral cort«i, 16 aapl«. CT la) «.» » 01 - 0.» I 3i.« 1 aaoV9 1 I) llppocaapM. 8 saaplas, CT 26. » 1 fl 2.6 t or - 0.3 1 1 aaol/4 1 titopiT Mipln 1 Dry «t \| 1 ss i cttmu COITXI: iBtsomm BITSOPS; t i ciicwi: ccptiij IBOI; MICKCSB; 1 \| (Bill; lUTCfSIIS 1 1 •ot giT«a \| 166.0 ag I C 1 «aapl«a at cat* of 1 !/•!•. 2-10 1 \| »i» aCtcc taralai a arc «UiB4 cods. 1 1 1 1 DalwsltT pVrsicB «kop, nocida 1 1 1 I fiotisa; HOLTS : BBHTB; ciictna; 1 1 CE101IIBJ CH9OHIOS: COVPBI: ISOI; I i ttiB; uieiiisK: ncm,: potissiust I t snrn: TITIITBH; TIBIOIOI; n«c; lit 1 1 fCILOTIOl; PMES: 1»SOSTSI»I 1 t ItBOSPBHES; TB1C1 ZIEIEVTS 1 1 1 1 a) lot givaa I a) 23 ppa I a) laanlaq 41nbl«« b) lot givaa 1 b) 22 ppa I t) Coatrols 1 1 1 1 t«»t»lm ------- lioo 1MV89-C »^ jy—»y w it U« SS.ga?. B 1535 c (pit), 1000-1300 C (cast), 1500 C (trtn^at). 1300 c (steel), B» 3000 C, T? 1 » 19 at 1787 C, 10 •• agj (coiiiioca) •t 200 c tISSO! 02 lair «0«3 Heart OM Kidney SIPOStJBJ BOO immcu. SKIOC n n BOB BBS or CASZS a) 8 W 3 a) 16 > 3 tIBCB a) J.»-68 a«/« (net rt) 1) 19-73 19/9 l«t »tl 6. 6-1(0 «9/9 (net it) 37-130 gg/g (mt vt) BBIB 1 fiEHBU. IBTQxBlTlOI 1 \| Bavlen. 24 represeatatim 1 tre-analTais treataaats are I tabelatel. The fcasibilitT of a I Bdllstic. eo-iash policy for hair I »ajysls is outlined anl support. 1 \| UllZt; TBJCt nitHRS; BUS; 1 USTBU.H: BIISOBIBBB IBTBODS; i KttLS; noTinsi ccwmtift \| IfUDlTIOIS; ILBBtlUI; 1RIBOIT; 1 itsmc: tuna: BHOBIIBI C»BBIOS; t ciiciaj; csiciiH: cssomas: conn; 1 CCFR; auini; cts«iiir»: eoio: t ICDIIB; 1ROB: lliTHITOB; IBIB: I MfiBMlfl; MIMIBSB; BgECtlBT; \| KITBDtmi: BICCZl; PBOSPHOBW; I foTission; tmazii; sncnoR; I SI1ICO1; SIItBB; SOBIOB; STBOTIOB; 1 SOITOti TIB: TITtnOB: TOICSTCB; 1 TIBC; ZItCO»JBB 1 t a) 38 » or - 20 «j/g \| a) Rales (•at t) \| t) Feaalea b) a* * or - 27 ag/9 j (vet t) 1 Itaa a ------- Irei . 7«3 -*-« 1C Itl 55.a«7, IP 1535 C (pore), 1000-1300 c (east), 1500 C fumaht). 1300 c (itecll, tr 3900 C. n 1 9 at 1787 C. 10 u Hg it Z0«0 C 1IS30I 4045 Kidney >04t liver a 047 liver tOSOBS BOni 1BJIRIC11 imoi Ba u mesa r cists a a 12 ) 3 b> 5 a) 8 b) 9 C) 11 IIB6I \| Bill \| 6EBIE11 IBMBS1TI01 1 1 51-148 og/g 40-513 og/g 27- 507 ««/? •t vt a) 29-150 ig/g («et at) b) 44-20 ag/g (vet vt) a) 81-391 ug/g b) 111-796 ag/g c] 91-344 io/g Bet vt 1 ) 79 ag/g 1 a) Contrail 94 ag/g I b) torkar grcap I 54 ug/j 1 c) Writer qtcip II et vt i edtans 1 teceasad refinery a»d seelter I verkers. agea 55-76 yr. exposed to 1 heavy ietala 1-3 decades. Tla« 1 tatieea retiremt aid deatk 0-1.5 jc 1 la groip I and 2—19 yr, groap II. I Controls, ages 43-72 yr, vho lived 50 I ki froa tne factory. Sveden. I t SIUI: ClBattSS; KID1ITS; liyiB; I 10B6S: coBPaBiTiTi BTHBITIOIS; I iBoasTniat iiftim: CTISOBEBWT t IRBOOS; iiiiBOii; IESCTTC; c»omna; 1 cis in a; CBBOBIOB; COBILT; COPPIB; \| GOLD: IS01; UBTBMBB: tSlD; I eifGMESI: HIBCVIT-. MtTBDXim; 1 fEOSPBOiis: BITBIDIDB: sciigitn; I SILEVIN; SHVEB; TIB; TVBGSIEB; 1 II«C; BEI1TB B1Z1SDS; IBDHSTBI11 t ti»ns; smiTSSS; Tnivnna i a) 62 * or - 68 ng/g 1 a) Bales (vet vt) 1 t) Veaalas b) 150 + or - 83 ug/g 1 (vet vt) 1 Itoi a grc«f of 61 aotopsi«3. I fereaaic aedical exaainatlona, Japan. I Bales, aeaa age «0. » yr. Tesalas, \| aaan age 37.4 yr. 1 \| TB1CI EIEBEB1S: 10TOPSIES: J1P1I; 1 tiBnBVB: iBsuic: cioaioB: COBILT; 1 CWCHOB; CCJSIB; isoi; BKBCDII: \| IBCIDB; SIGIISIDB; BIIGISESI; 1 JOBID10!!: IIKBOIT; SC1B9IOB; \| SIUIHJ1; TITMIOa; T1B19IQB: ZI«C: \| 6CID; IBOIfll!: tlVIB; HDIITS; I CZlE9B>n; CIBtBEUIB; HE1BT: BDSCLBS; I ElBClElS; SFUEI; LBISS; >O»1i: I SITUS; COBP1B1T1YS STIHHTICKS; SII; I fCBMSIC BIIICItE 1 1 a) 246 ag/g \| a) Controls b) , 198 ag/g \| c) Vorker gtcap I c) 139 ng/ ------- Horn 739-89-8 It 55.M7. BP 1535 C front. 1080-1300 C (east). 1500 C (roait). 1300 C {ttaol), » 3000 C, n 1 n Bg «t 1187 C, 10 •• 1« at 200 C 1X359 0«t LM« •••"^ •09 Ilia •050 leaf BIPOSO! wnm allLRXCU BETBOD a it Boaabaeer TOBBH \| IUEI or cuss i i I 3 1 112-280 ag/a \|v«t M) \| \| • \| \| I \| I I I 1 I 1 1 I •18 It) 122- Kit ag/g hj 9 \| b) 80-«C8 19/4 d 11 \|C) 32-»23 ag/g I (t M \| \| \| \| 1 \| \| I \| 1 \| I 1 1 1 1 1 1 1 a) lot glT«a 1 k) lot gi»a» \| c) (at gi»«» 1 d) lot 9iT«c I e) lot gii«> I f\| Ht glt«n 1 g) lot gl»« 1 h\| lot gl»«D 1 1) lot giwa 1 1 1 1 1 1 I mn i GZIIUL imnnnoi i i i 200 • or - It q/g I «•!«• (Mt t) I 1 icot * oroip of 61 utapclcc. 1 £cr«««lc >«dlc«l •nilMtioni, Japn 1 !•!«, •••• 19 0.t yr. r«ul«s. I •••• •«• 3T.« yr. 1 i IIKI nuira: anaMiiS! JIPI»; 1 iioims: iiscvic: c»ai0B; cosnit 1 cHOBina; comi; 1101: nicni: l utiva: iieiisim: nvemsi: 1 18110118: tMX80R{ SCIIDIOB; 1 snmira; TmiioR; T»«Binij sues l cnir SBOMIIS iifras IIDIIIS: I cnzsm; ninsuii8: auit: ROSCIIS; \| F1ICRI1S; SFISXI: 10«S5J JOKJ; I iRiLS; coHmuin nkivuinsi SBI: l fctinrc siDicifB i •1 303 19/9 1 > Cootrols k) 139 ai/g 1 fe) fotkct gtcav I el 13* >4/g 1 c( >ork«r 9tc«» II Mt t I Icdlau 1 t «••»« rcflMrr >•< neltor 1 >otkr>, aqi SS-'e yr. exposed to 1 b«»Ty Mtal* 1-3 4ead«s. Tie I t«tm« ntln*«t a4 i«atk 0-1.S yr j li gcaia I ail 2-19 yt, qroap II. 1 ccaitrols, a«a« 3-72 yr, >o lii«4 SO 1 ki (toi tie factory. S«e4««. 1 l sitint cititBS: Knms: IITIB; \| ITJISSi COniHTIft SM1WTIOJS; l iiDvsrnai nenn; ntsTinniT I MtBODS: iniBoii; IBS me ; C»DKOB: l ctsivt; citonni; COBU.T: cowsi: 1 COLE; noi: uirmoa: LZIDI I iifeitEtt: ttncuti; aomntmis l tcospaoiDi; tmiont: sen mm: I 3 n mm; sitrsBi Hi; TOIGSTM; 1 TIIC; II11T8 UZUBS; I>DVSnial t fiins; sannisi tiuoaian i I I O.m \| a) torial ) J. »5* \| k) Beaosidtroals ) 1.0M \| c) lette btoacaltia 1 0.16* Id) coalvoctcc ) 0.621 1 •) caalvork«i I 13.5* 1 t} Boiatit* rarkar 1 1.99Y I q) TomlCT vetker ! 0.37* 1 h\| coalvorlrec. Fir l»aloi > 1.33 \| 1) Saa cotl«ork«r, excladlaq PIT Feicent ixj t 1 Itslos 1 l(aiarm«ta corraetad foi 4ist 1 coitait. ( I vinio niGCCTi i9TR,n; nn«: I KUSflinSIT BETHOTS.- I§0»; DOST t smmcs Tak»a> B. Sazqki-Ianaoto, «. laaao, K. Tacal. a. 1980 Iiekiva of UTiroaaoital Haaltk 35M):36-M Braaa, D. lordbacg, 6. lastar, P.O. 1980 Scincf of tbe Total Intitoaaent 16:13-35 GDest, 1. 197« laaala of Occapatloaal Hygione 19:49-62 (KIT P16E) N) ------- Iroi 7t39-»9-< F« It* 55.B4T, BP 1535 C (pin), 1000-1300 C (cut). 1500 C (ixoigit), 1300 C (steel), BP 3000 C, TP 1 •• Bg at 1787 C. 10 •• Eg at 200 C 1ISSBI 40S1 Bncle ton taicnai 4053 SBllal earl MPOS018 MKI 1BIITTIC1I SET «00 11 » I-ray spectral IOBBE8 or cisss •> > 3 «1 5 b) 3 •» 7 tj 12 Slid ) 11-54 n/9 (Mt •) ) 1fr-»7 ««/« l««t t) «.) 12-48 «V9 <«t «tl b) 1S-67 »g/g («t lit) •) 28.»-1B1.5 »g/g b) 24.0-122.5 ig/g DtT t nn i Giniii MratMTioB i i ) 26 » or - 20 09/9 I i) Riles \|»»t »t) \| t\| nnlci b) 27 * or - 17 19/9 I ««t »t) j Iroi • gtalp of «1 aitopllvi, 1 foMnie Mdieit ozil»tiau, JapaB. 1 Btl«a, mi q« 40. « Tr. T«Mln. 1 •«• «g» 37.4 ft. 1 I T1ICI 11EBIKS; HTTOPJI1S: J1P1I; 1 tunng; nsnic; ciomtia: COBUT; I cnogivR; come 10: IEICUBT; 1 iieni: iiensiiM: iiieiitss; 1 Mturn; imaoR; SCHIHOH-. \| SH.HIOS; TITillOl! T1I1DIDS: ZIK: 1 eott: Bsoiiii; tun: ntins; 1 ctustTM: cisraeum: HSiM; ausciss; 1 PMCII1S; SHIER: 10«S; lOITli I SITUS; COIPlllIITt OT110HIOS; SSI; 1 1C1MS1C B»K»« 1 a) 32 • or - 17 ag/9 I at flalvs <»«t it) t I) raal«* b) 47 t or - 28 ag/« t tnt «t) \| Iroa a groip el 61 aatopslec, j teiamslc •• ------- Itoa 739-89-6 T« lt» S5.8»7, IP 1535 C (pore), 1009-1300 C (cast), 1500 C (noaght), 1300 C (ctMl) , B 3040 C, TP 1 ai 19 at 1787 C. 10 aa Kg at 200 C iissm os* SpleeB EXVOSISI tan* nitnicu n Of USES a\| 5 B) 3 mot a) 57-«10 «g/g (net rt) fc\| 150-590 09/9 {vet vt) BZ»P a) 369 * or - 10 og/9 («at «t» b) 30 » ot - 330 a9/9 (»«t vt) GZIZ111 MTOBB1TXOB a) Bales l\| Teaales fro> a group of 61 antopoie«. forensic aeiieal examinations, Japan. Gales, aean eoe 06 vr. Feaalea, tean age 37.* jr. imcj zizvzits: JOTOPSIZSJ ji»»»: llORXBOB; 1B5Z11C: C&SBIUB: COZILT^ CnCBtOB; COmii IBOI; 5UC13HT: Konn; Bisiisius; BHGMZSB; •OfZDIOH; JVTZBOR; SCAmoB; stinna; muian; TIIUIOB: z»c; eciD; BioBiiz; iitzu: KIDXZTS; CtBIBHIl; CZiZBIlIOB: BUST; B03CLES: FMCtllS; SPIIEf i 1VKS; JOBT1: 9II11S; COD7IMTITK ZT»10»TIO»S ; SEI; TCIZISIC B»ICX» nnazBcz Titkava, B. SBinki-Tamaoto, a. 1KB9, K. Teral, a. USD XBYiroiiMBttl Dealtb 35(1}:3«-M Itobttrl tlcckol (« CI( t-Prapanol. 2-ntkrl- (9 CIJ 7. 12. BP 107.40 C. TP 10 aa 89 at 21.7 C iissnz •055 Breata •056 Ecaath ztPosoiE xonz 1U1RIC11 BZTBCD oc/as sons IDBBEB or CISKS 8 5 (387 saaplesl Eiies lot detect «S-3 1.0 ag/hr lot glrea izii 10. « ag/hr 0.328 09/1 Seoaetric Gtllnt IWTCSHtlOt ccacand related to earaal xtibotia. lo otter detail! gireB CryogeBic flaapliag techBl9ve. BcaltkT ailltarr a>4 civilian caeloreea. O.S. llr Force School of Jcroapace leiiclcv, aoes 23->7 jrt. 3 EtoIierB. CtlZnZS; CBIOIIIITED BTBBOCISBOS; cBtopiir of sine coaponos; cfiosomzzizs; rnomn COBPOOIDS; UllTB; I1CC80LS; THIS; 1DTCTS tcatarel at 25 C aad 760 » 89 13. tl occirreBce lever aad aff«r oae-sigaa Halts 0.06A and 1.19 ig/1 B«altar, 18-35 rr old, aonsMkivg, artaa blacks aai Caucasians. Ckicaqo. 11. SlqldlT cootcollea •xpariaental eoilitiois. IltlTI; alCCBOlS; I1UIOIS; « DOLTS; cnonitTZE insociiBois; >OIIILI cieanc coBfcuins: BZUTB BIXUBS; lIBtliTTCI; ESTtEOLISB: HMIEOLITES; fCPJUTIOJ IIPOSOW; tJBBU 1BZ1S SE»B«Z»C« COBkle, J.p. Caap, B.J. Velek. B.C. 1975 IrcLiTes of far! ronaeutal Health 30 f 2) ; 20-295 Krotoazjxaki, B.K. Bronean, S. B. C'leill. H.J. 1979 Journal of laalrtical ToiiiologT 3:225-23* ------- iiooctrl alcokol it at Icooctaaal (9 CI\| 2C52-21'6 C6-B18-0 «« 130.22 1ISSB1 • 057 Bnatk EIMSOtS BOOT! iBaiTtxcja BETHOO SC-BS (OIBZB or cists 54 [387 suplea) BUGS lot given Bill 1.3 n«/l SeoMtrie eiBiBit irroBBinoi leagued it 25 C and 760 la Bq 1!.IK occurrence loner and «pper o«-Slqa limits 0.33 aid 5.1 n«/l Bealthr. 18-35 rr old. nonanokliq. urban Hacks ud Caucasians. Cklcaqo. 11. BlqWlT controlled EStlTB; UCCEOlSj I1HBOIS: 1DHIT3; CnOBItllEE BTDBOCtSBOBS; TOL1TXL1 CSGIIIC COSSCTJJB5; BC1LTH HatUtS; IBBU1TIOB; BETIMIISS; BETlBOltTBS; PCP811TIOI EIPOSBREt IBBM »EE»S lERUBCE Krotanfnskl, B. K, BrQiiejaii. Gf I. O'J.ill, B.J. W79 Journal of analytical Toxicology 3:225-234 Iop«itTl «lcohol (B CI) 1-ettaaol, a-Mtkrl- (» CI\| 113-51-1 C5-B12-0 II 88.15, BP -117.2 C. S» 132 C. TP 1 M eg at W.O c lissnt •058 ' •05 areatk EIIOSOBB BOatl aBU/nidl BWBOD sc/as ec-Bs BOBBSS OF CUES 8 .. 5» (387 B1BGE Bot detected-2.6 og/ir Bot firei Bill 0.3 J9/hr 0.182 aq/1 Geoaetrlc GEIZBlL ISTOBB1TIOB Ccatoand related to normal •etabollsi. lo other detail! tjiren Ctyoqenic aaaplLno tecnni^ive. Bealtk7 illltary and clrillan oployees. 03. ale TOEC« Sckool of l«roapac« Badlciae, ages 23-47 yr. 3 nokera. IinEBlS; CBlOtlBlTEC BTDSOC1BBOBS; CtLOHBC 08GUIC COBPOOTOS; CBLCBOBBftZftS; nnOBKE COBPOOTOSj HIHB! IICCBOIS; TITaSi IDBITS Ceamred at 25 c and 760 am Bq 29.11 occurrence lover and mpper one-si?. Unite C.942 aad 0.781 no/1 BealtkT. 18-35 yr old. nonscoklnq. iclan blacks and caacailana. Cklcaao. 11. Biqldly controlled eiperliental conditions. EB1HH-. alCCBOLS; IUI10IS; 1DOLTS: CElOBIBltED ByOBOCaBBOIS; TOlltllE eceinc coBScnrgs: BEJITH mutest IBHIUTtOt; BETITOLISB; HBTlKltlTBS: tCPUll'IOi EIPOSOBS: OBB1B atEaS 1 BETESEICZ \| 1 1 1 Conkle, a.t. I Caap, B.J. Velck, B.C. 1975 arehlrea of environmental Bealth 30 (2): 290-295 KtotonTBrtl. B.K. Bronean. G. fl. 0> Belli, B.J. 1979 Joncnal of Inalytlcal Toxicology 3:225-23 ------- 1.3->lt4UM. 2-MtkTl- (9 CI) 7I-T9-5 C«-I8 H Ca.11, IP -16.1 C. BP 3* C, T» «00 •• (9 at IS.* C ussai aMO Enatk «0«1 BTMtk •062 Brmta 1 1 1 1 1 MPOS01S BOOT! i ttunxcu I BTTBOB OC/IS «C/BS GOBS IDBB» or CISBS " 5* (3«7 saaplul 1IIG1 0.09-0. «5 ft* lot dcteetad- 390.0 »q/ar lot give* •Ell 0.23 pp* 129.8 as/he 28.9 «/! seoaetric GBIIUI xiroiBATioi correct 9 for level IB Uktl«4 »ir Maltkr adalts S1EIEC IDUIISJ BEaSminBT BREO9S: CCBpovBd c«lat«4 to BorBal CiTO9«Bie aaBpliaq toekniopa. a«althr allitarr ui ciflllan •iploy*. D.S. lie force Sclool of •BO tor. t Hints: cBioamtio BTDROCIBBOIS: CROim OISIiTC OOIPOnOS; CBicsoniiiirs; niioim CORPOVIDS; ElflXB; 1ICCBOIS: IEHS; ICOTTS t«nr9 «t 25 C and 760 IB Bq 7Qt occnrccnoa Ioi«r aad apper oo«-Si9»« Halt* 1. ia< 58.3 na/1 Hcaltar, 18-35 yr old, nooaaoklair, trtaa klBClta and eaieaaitaa. ckleaga, 11. (laidlr coBtrollvd »tHH: Hcciots; iiLiwis: iDOt-s: CBtOBtfHR) nOtOCllBOBS; TOIITIIE cm tic coetcnns; BIUTB Bizurs; IIIIIITtCI; KRABOtlSI; BR1BOLIT5S; fOIOllTIO* EIPOSOBI; U»Ba» 1BB1S nrsiEic: jam»OB. B.O. 1969 Joarnal of laboratori tad Clinical Hetaoi* 74 »«> : 9«l-96« Cookie, J.P. caap, B.J. »975 * irehirea of tBTlronaental Bealtk 30f«;290-»S ttotaaziulii, B.E. O'Jeill', B!J! 1»7» Joiraal of laaljtlcal ToTicologr 3:225-23* 1 CT- alcohol (8 CD S-Propaaol (t CI) C3-H-0 it «o.o9, BP -ee.s to -ss.s C.BP eo.3 c, t? M e« at z.« c TISS9S Bxattk ixiosni ions tuiniciL 8RBOD ec/vs iraBn or CASSS i tlKK lot tot«ctd-1EO.O B«/kE tim 38.6 ag/kr JlSt) 6IIIU1 II7OIB1TI01 CCBFoni related to aotaal aetabolisa. Bo otkar detaila qiT«o (••ItkT ailltary aal ciilltat ------- alcohol f8 CI) 2-Propaaol {» CI) «7-«3-0 cj-M-0 •I «9.99, IP -88.5 to -89.5 C.BP 80.3 C. ?P 10 n H« at 2.4 C IISSO! 4064 Breath BUOSOII BOOTH RRHOO ac-as IDBBES or casss 54 (387 saaples) 11KB lot given am a. ess ng/i eeoMtric eiinat IIPOBSITIOB (ea sated at 25 C and 760 •• Bg 22.2V occurrence lever aad upper oM-Sigaa liaits 0.1 55 aad 2.76 aq/1 Realthv, 11-35 Tt old. nonsmoking. «zraa blacks and cancasiaas. Chicago, n. Bigidlr controlled experiaeatal conditions. EBCHK; UCOBOLS; IttlnOIS; (DOLTS; CflOtXa'aTtt BTOBOCIBBOIS; TOttTItB cismc C05PCU1DS: BBU.TB BIZIBDS: iiaiUTiot; atriBoiis>i: arTSBOLiris; •OC011TIO BnOSOK; «SBM IBIaS BHBSBICI Krotosxynski, B. K. Branean, 6.B. O'Veill, H.J. 1979 Journal of analytical toxicologr 3:225-234 lactic tcU, batrl ««t«r (S CI) ttenanalc acU. 2-kydroxr-. batjl ««t«r (9 CI) 138-22-7 Cl-BU-03 IB 1U.18, n -»3 C, BP 188 C. TF 0.» na 84 at 20 C tlSSQl »0€S Br«4th BIPOSOS! B001E alllRICU. acTROg ec/as BOBBn OT C1SBS 8 BUGE lot detected-3.4 ag/hr BSl 0.4 ag/hr GIIIB1L IIFOBBaTIOB Ccifoaad related to nornal aetabolisa. Bo other details qivea Crrogeaic laapling technique. Bealthy ailitaCT and civilian eaplovees, o.s. air force school of lerospaee Bediciae, ages 23-47 yr. 3 aaokers. tHIIUS; CBtOBIIHBD HTBBOC1B90HS; CBLOBTBB OB6IBXC COBPOOUDS CB1CBOBBIIIBBS; FIOOBIBX COBPOUBOS; CBtaTB; alCCBOlS; THIS; atVITS BETIKEBC1 Conkle, J.P. Caap, B.J. Belch, B.E. 1975 Archives of Bnvironaental Health 30 (2): 290-295 ------- latthaii* 739-31-0 la Ht 138.306, n 920 C. -at 3«» C. TP 3230 » Hg »t tOO C, 320 « Bg at 760 C IISSBI 40C6 Bale »OS7 (UMT «WS line \ EXPOSURE BOOT mtnxcu, BCTHOD tl n 1 OB 8X3 OF cms aj 8 b) 20 a) B 1 9 cj 11 BIKE •1 < 0.06620-0.00040 og/g b) < 0.00020-0. 0«6 vg/g •et »t I 0.0030-0.01* ogyg I < 0.00020-0. 051 sg/g 1 < 0. 00070-0.02* og/g •at vt BUI \| GEIEXII. nTOMirXOW 1 1 1 t«i«. 2 cepreaentatin 1 pre-aaalral* treatment* arc I titillated. The feasibility of a I holistic, no-«a>h policy tor talc I malysis is cotliaed and sqpfocted. 1 I mm; TRICE BimiTS; tun; \| USIBII.I1: BIlSOBMBiT RETIODS; \| (ITILS; PSOTIIIS: COBP1B1TITE \| ZTllOitXORS; UIBIBOB; tlTIKXl; I isswic: Bisins; iioian; CIBSIOT: 1 ciicin«: CBtoBim: cBBOsias: coeiir; 1 ccppti; c«iLHJ!t; eiigiim; GOIS; I icDin; iBoij iinflMira; LI»: I B1EKSIRI: IMSIIZSXi HBBCUBt; I CCIIBIIBOI: IICKILi PBOSPBOB0S: 1 SOIISSHJB; tmiBIVi; SEtEKOM; \| SILICOtl; SHTEB: SODI5B; SIBCITIOB; I snrn; in: IITIIIDB; tncsm: I me; ziiccizoa a) ttot give* 1 a) Coatcol* b) Sot glTen 1 t) «oc«rt, qroap I and II 1 1 teas«a cefinarr and saeltci 1 lectori, age* 55-T< rr, ex posed to 1 «a»y Mtals 1-3 decades. Time I t«tnea cetlteaent ani deatk 0-1.5 IT ( ia groif I ad 2-19 rr, qro«r !!• I CQotcoli, aa«a 372 rr, »io llTed 50 1 t> tco* tkc factory, snedan. 1 1 stinx; cin»»EES: Kioms: iiTii; i miss: cofpnirtrs mmTiois; 1 IBDOSTJIll BtGXtHi TO1SOBMWT I iMBOBS: aiTiiofi: IBSEHC; CIDIIBB; I CIST9B; CBTCBIVII; COI1LI; COPPBS; i eott; iBof; t.naiitiB: I!»D; I «lI5HISf: gfSCIIBT: BOlTBOEWni; 1 IEOSPBOB5S: BOBtKoa: scaioira: I SHZIIOl: SltfEB; TI«; TtJISSIII; I IIITC: SUITS B121RBS; UDOSTBIII I FURS; smnnsj tainaioa 1 > O.OOSO ag/g I a) Coatrol ) 4.00SI ilg/g 1 b\| locker «ceap I t 0.002 »g/g \| c) Bortec groap II at vt 1 e4iaa 1 t«c«aa«S ref iiecy aaA SMltac I vockacSp avel SS-T6 Tt« «zposvd to 1 teary aatals 1-3 4«ca4«3. file 1 tatMea cctlcaMit and deat* 0-1.5 yr 1 In qtoip I aid 2-19 TC, ocoap II. t ccatrola, q«« 13-72 rr. vfeo llwd SO 1 ki fro t>« tactory. S««daa. 1 SlltW; OB1TKBS; KIDtEIS; U?S1; I imas: CO»»ITITE IT»II;ITIO«S: i ncos«iit item:; «stsng«nT 1 fiTWis; UTisom: IBS me: cisnaa; 1 CtSIflU: CBBOSIHB; COBkLI; COPVSt; 1 SCICJ ItOI; IlITBtlOII; llllj 1 IIICallSE: BIBCUBt: SOLTBDIIUS; 1 ItOSfBOtOS; (OBIITQRS SCiiOIM; 1 sutiimi: siitii; TIB; KHQSTEI; 1 I11C; 1C1H1 Bktaags; IIDOSTSIU I mnst s»EiTE«s: TBLLTOID^ l lEFESBllCE Chlttleborongh, •;. 1980 Sclaica of the Total EOTiconaeot 1«s53-7S Dcnoe, D. I>ecdbec9, s. Hester, P.O. 1980 Science of tie Total EBTlcoaawBt 1«: 13-35 Brnne, D. lordberg, e. Vester, P.O. 1930 Science of the Total Eavlronaeat 16:13-35 (•in net) 00 ------- ll It* 139.906. » 920 C, BP 3S« C, TP 3230 M Hj at «00 C, 320 m Sg at 760 C (COITimO) H3SH «oc* tang EICOSOIE BODTE Hitmen BETEOO Ba OF C1SES a) 8 bl 9 cj 10 BIKE a) 0.00030-0.023 ng/g b) 0.00030-0.17 ng/g c\| 0.0010-0.025 og/g let t BE1I a) 0.000 aj/g b) 0.011 ng/g c) 0.011 ng/g let vt tedians GJIIBJll IIFOB1UTICI a) Control b) Sorter qccnp I c) locker grenp II Ceceaset ceflnecy aad sneltec rackers, ages 5S-76 jt, exposed to k«ar aetals 1-3 decades. Tine t«t«een letlceient and deatk 0-1.5 vr it groan I and 2-19 TC, gcoop II. Centrals, ages «3-72 TC, vko lived SO « ftoa tke factorr. Sveden. SIEBEI; CID1TEES; KIBIEtS; LITI3; ITTI6S; CORPlBlTXtB BT» LUITIOJ5; BITBODS; 11TUOMI:' IBSHJIC; CIDSIOH ; CEsnm: CBBOIIOB; COBILT; COFPEB; GCID; noi; IlITBalUB; LEU; !1I611ESI; RtSCOBt; HOLTBDIIOB; tsospaoBus: praiDiut; SCIBHTOB: sitEiiiTB: sum: til: TOIGSISI; JliC: BialTB B1Z1BDS: lEIDSIBIal tlins; SIEITERS; TEIIOSIDB ESniEICE Bctne, D. loclbecg, G. tester, P.O. 1980 Science' of the Total EaTicoanent 16:13-35 I lot given (IEXT 8EaB I I ») 28. » + oc - 7.6 iq/W nl b) 27.* * oc - 8.1 aq/100 al c) 30.0 * oc - 9.* aq/100 il d) 27.1 * oc - 7.* ag/100 al P«GE\| eilRlL IIPOBBITICS \| 1 a) CIS stlftcaa t) M CIS ayiptoas c) SI araptoas d) Gl aynptoaa significant eoccelatlon p < 0.00003 1« snblects «ith CIS syapteM and p < 0.02 la safctects «ltk GI sTaTtoas. Be* Tort CltT telephone cable jplicers, eiclored S oc aore TT. Ciec SOt vece <30 TC olJ. l«acological and gastrointestinal •Ifftoaa. Ilevated ztnc protoporphyrin levels. till POISOIIIG; KDOS1BIU POLLHTIOI; IIDOSTBIII I1DICIIE: LI1D; K« TOEIC; irmiS; CEITBal BEKVOOS STSTEIt tIStlStS; IIIOSTIIaL DISUSES; BLOOD BEFIBEBCE riskbeln. 1. Tkocaton. J. Bloaberg, B.E. Bernstein, J. TalcUlias. I. Hoses, fl. 1>arldo«, B. Balkriskena, E. Sicota. H. Sellkoff, I.J. 1980 laerican Joacnal of Pablic Health 7 0(7\|:« J7-700 ------- lead 1429-M-1 ft atl 207.2. » 327.4 C, BP 170 C, vp 1.77 SB Bg at 1000 C. 1 •• Bg at 970 C, 10 u 89 at 1160 C (COirilOED) T.XSSBB 071 Blood «072 Blood 4073 ood BXPOSOBB BOO iBhalatiOB halatios IIIITTXCIL •IT BOD US us s IOBEJS OF CaSSS 160 « 32 It BUGS a) 16-2.0 eg/dl b) lot given c) lot given d) lot given ) 18-36 «g/dl ) 18-32 ug/dl ) 48-90 ag/dl ) 40-90 ug/dl lot given lot gives Hal I 6EIIUL liFolaaTloi 1 I 1 a) lot given 1 a) sorters IB saelters and cieiicals b) 41. « ag/dl \| flaat c) 82.6 ag/dl \| t) Cffice aad laboratory workers IB d) 87.2 ag/dl \| 1» «Mlt«r I c) Prodactica worker la Tl >B«ltec 1 d) Cl«aa up aad Baiat«aaac« vorkers I la Tl sa«ltec 1 loaitiTe correlation Titi daratlon of \| «aplOTB6Bt. 1 j loilnca ia secondary lead (Belter, j leaphla, Tl, la scrap aaelter. Salt \| lake City, IT, aad at 2 lead j cfe«Blcals factories, Joplia, BO. 1 j Clialcal evidence of toxic ezpoavre j la 70 (ockeis: fatiqae, colic. j gastrointestinal srBFtOBS, anorerla. j afalgia, joiat pain, objectire j treaor, eitansor sascle veakaess. 1 possible eacepaalopathy, aaeaia. lo 1 toiicity detected at < 40 og/dl. 1 \| Vl€v«ted blocd Bcea altro^ea, cednced 1 c teat lain* clearaace, decreased ranal j COBC«B testing abllltr. 1 \| ItlD POISOIIIG; IBDHSTBIIL FCLLVTIOI; \| SBtltBBS; IICISTBI1I IEDICIK; IBID; \| BISSOUBI; TtlBBSSn; OTiH; 1DOLISJ \| tlOOO; BIOlCCVBOXaTIOB 1 1 a) 28 og/dl 1 a) Coatrola, boys b) 20 ag/dl 1 b) Controls, girls ) 68 ag/dl 1 c\| Bora ) 63 ag/dl 1 d) Girls edians 1 \| ?«tlent3, aaes 1-3 yr. 85% black, 10V \| Blspaalc, S* vnlta r j iBcream in systolic pressarc vita j concentrations of > 40 ug/dl. 1 \| CeltOlM; BYPEBTEISIOS; BLOOt I IIESSBK!: 1EIO: BPTILS 1 S3 * or - 16 1 •> (orkers, exposed 2-37 souths (Bean g/100 al j 12.9 aantks) , average workday 11.5 11 * or - 4 ag/109 1 tr, average work days 28.S/»onth 1 t) Costrals 1 1 Bale BD, ia aine corkers, Raraorilik, 1 ages 23-46 hr, e«aa kt 1.76 s, eeaa 1 wt 76 kg. Ccatcols, 4 office workers 1 at aiae, 10 ttaiTersity students, ages I 23-42 yr. Bean ht 1.7S B aad aean wt 1 7« kg. I lo observed decrease of aotor aerwe 1 ccadaction velocity of the alaar 1 aerwe. 1 \| tllHlBK; ISO ITS; LZID POISCIIIG; I IITTOVS STSTIB BISHS!S; BLOCD: 1 [IClCCHnllTIOI; IIDHSTBI1L \| ECLH1TTOI; llaD 1- Esratncc Baker, B.L. , Jr. laadrlgan, P.J. Barbonr, I.G. Cox, D.B. Folland, D.S. Ligo, B.I. Throckaorton, J. 1»7» British Joarnal of Industrial Rediciae 36:314-322 Jhayeri, B.C. Lavorgaa, L. Dube, S.K. Glass, t. (Than, F. Eaas, H.I. 197» pediatrics 63(4):674-676 PaalST. P. -I. Sry, C. Dossiag, 1. 1979 International archives of Occupational and tBTlronaeBtal Health 43:37-43 -J o (BUT Past) ------- 739-92-1 ft Itt TOT.2. BI 327.« C. BP t7M C. 1.77 M f« «t TOGO C, 1 •• Bg at 970 C, tO •• Mg at I ISO C (commit) HSSUB »07« Blood 075 076 Blood BOT7 Blood rostriB HBTB aalatloa BgestiOB 1IUTTICU UTBUU US us us us •VB8EB 1 UIS8 or cuss i i t 1 I 40-30 Be/l 1 \| 1 1 1 \| 1 55 1 a) lot «ITCB 1 b) lot give* I c) lot gives I d) lot give* I •) lot gl»«» 1 f) lot gl?» 1 I 1 I 1 I I 1 i I 99 \| a) lot gl»e« 1 b) lot givn 1 cl lot giT«B 1 d) lot glni I a) lot glf«B 1 f) lot glea 1 I t 1 1 1 1 1 t 1 IS I B) 3.1-13.1 aaol/1 I b) «.2-1).t eaol/1 1 1 I I I 1 1 1 1 m i ecnuL urouuxoi 1 « 1 lot flliw 1 tatlaatai frcB qrapk. Direct I dotenlaatloe a»l •stractloa • I letters, garage pereoBnol aid potty 1 lockers IB Svedlsh atrplaao factory. 1 \| lIDBSTVIlt ICUBTIOI: COBMIMXTI i ininitioirs: caDH0i: SIEDEI; IOOITS-. \| BIOOT; nilt; BIOlCCniOlJlTIOl 1 1 1 22.9 og/100 il 1 B) !«•• < 21 It. wpoicd i 32.7 o«/100 al 1 b) loos 50-61 ii, oraoaod i 37.2 ««/100 Bl 1 c) l«o* 70 aa4 em, exposed I 19.1 19^100 al I A) >o« 20-29 rr. eomtrols 1 20.B if/100 al 1 •) lg« 5D-6« rr. eoatrols 1 17.3 oq/100 Bl 1 C) « 10.93 ag/100 el 1 laterclaeq. saloa e) 1.93 og/100 al \| el 17 so after opeelag of n 19.21 vg/100 al I litereaaaoe. Bales I df Before opaninc of isteccaanqe. 1 teaalea 1 e] 5-9 BO alter apeBiag of j iatareaaeqe, feaalea 1 t\| 17 BO after opeaiag of \| intereaaaqe. feeales 1 I tesideat* eitklB MO • of Uoavar 1 laterekaaqe tm tke V.C. 1 \| QltYBO VII60CB.; BIOQO) UiO; BEtklSl \| lOTOHOTm 1 1 at lot give* 1 a) 3-11 jr eiposar* bt lot gl ------- lead 734-42-1 Ft «tt 207.2. IP 327.4 C, BP 1740 C. TP 1.77 11 Hg at 1000 C. 1 •• Hg at 970 C. 10 11 Rg at 1160 C (COITXIOED) TISSSE 4078 Blood 4079 Blood 4080 Blood 1081 Blood EIPOSORB ROOT ngestlon nhalation iiaimcu BETH 00 IIS 101 BES or cisss 110 a) 56 b) 70 c) 50 d) 69 40 BIKE a) lot given b) lot given e) lot given d) lot given a) lot given b) lot given c) lot given d) lot given e) lot given a) 15.1-20. t ag/100 nl b) 11.8-14.9 ag/100 nl c) 10.4-11.1 ag/100 nl d) 8.0-9.6 ag/100 nl lot given lot given lot given lot given Bill \| GEIEBAL IITCBH1TIOB 1 a) 32.5 og/100 nl \| a) Blacks, Jane. 1970 and 1971 b) 21 ag/100 nl I b) Blacks, Bee-larch, 1976 c) 23 ag/100 nl 1 c) lispaaics, Jane 1970 d) 18 ag/100 nl I d) Rlspanica. March 197C I Geonetric neaas. valnes estinated 1 frcn graph. Seasonal pattern. I decreasing trend froa 1970-1976. j levels correlated with gasoline Pb 1 I JE-36 so olds, lew Tork city I it tost; eaiLDRii: item STUDIES; I BLOOD: COBPlBlTIfE ETALOATIOIS: LEAD I BITALS; ADTOBOTIVE; POPOLAIIO* \| tlPOSUBE 1 a) 55.8 * or - 9.7 I a) 58 aonsnokers ag/dl \| b) 23 snokers, < 1 pack/day b) 57.7 + or - 13.7 I c) 29 saokers, > or « 1 pack/day ag/dl \| d) siokers, high exposare (860 og/cu c) 60.9 * or - 12. 1 \| n) ig/dl \| e) KoBsnokers. high expasare (860 d) 64.4 « or - 11.8 \| ng/ea it ag/dl \| e) 57.8 + or - 10.8 I Sielter workers, average age 40.8 * ag/dl j or - 8.2 yr. Los Angeles* \| CILirOBHIA; BLOOD; IBID: RETA1S; \| CCC071TIOIAL RAK1BDS; POPOL1TIO1 \| ZIPOSVB^; SKELTERS; SROKIIG 1 1 a) 17.2 ag/100 si \| a) Bales, Los Ingeles b) 12.8 ag/100 nl I t) Feiales, IDS Angeles c) 10.8 ag/100 nl \| c) Hales, Lancaster d) 8.8 ag/100 nl I d) Feiales, Lancaster Geonetric neaas j Areas differed p«.001 1 \| PITALS: PLITIIUB; PALL-ADIOfl; HID; 1 ECEOIITIO* inOSORE; OOCDFltlOIAL I BIZAP.CS; CA1IFOEIIA; AOTOPSIIS; I eiocD; xiDiETs; SPLEES; BAIR; OSIIE; \| I DIGS; BVSCLF.S; ADIPOSE TISSOS: \| IITBS; COHPABATITE ETALOATIOBS; III \| JtSSEI; CII1DA; HtlllS; A0TOnOTITE 1 1 1 16 ag/100 nl I a) Start of enploynent. no previons 1 55 ng/100 il \| occupational exposare I 78 ag/100 nl \| I) 10-12 wk after enploynent 59 ag/100 nl 1 c) Siplayees relayed fron workplace 1 luring study, at tiae>of rencval 1 d) Enployees cenoved fron workplace 1 daring stady, 16-18 vk after renoval I Considerable difference in rate of I change and tlateaa state for Pb and j la protoperthyrin 1 1 lead snelter workers I A cons : BLOOD; ERTTHBOCTTES: \| IICOSTBUL BTSIEIl; LEAD: IIIC I OfiAITC COSPOniDS; IIDOSTRI1I \| MROSPRE1ES; IWBALATIOI; SRFXTERS; \| CCCUPATIOIAl BtZARDS; CORPtBHIT?, 1 RE'EEBICE Billlck. I. 8. Cnrran, A.S. Shier. D.I. 1980 Environmental Health Perspectives 34:213-217 Brown, C. P. Spivey, G.H. Valentine. J.I. Browdy, B.L. 1980 Journal of Toxicology and Environmental Health 6:877-883 Johnson, D.E. Prevost, R.J. Tillery. J.B. Caeann, D.E. Rosenfeld, J.B. 1976 EPA-600/1-7S-019, 235 PP. Besley, K.I. filbish, G.B. 981 Journal of the American ndastrial Hygiene ssoclation 42:42-46 N3 (IttI PIGI) ------- lead M39-93-1 n lt» 207.2, II 327.* C. 8P 170 C. TP 1.T7 » Bo at 1000 C, 1 •• Eg at 970 C, 10 M Ba at 1I«0 C icawnmrn tlSSOS «02 Blood •oej Blood • 08* Blood 4085 Hood •OBS Blood IFOSOU XOtJII lakalation Ingest ion ifUTflcit BRBOD tttUTone US us us mat SB OF CISBS 13 1 a) 18 b) 12 100 1 IMSf lot given lot given 1 3.7-9.* QBole/1 a> lot given b) lot giv«n 1.0-13.0 «g/108 Bl a) lot applicable b) Ml applicable Bill «1IESU. IHFOIMTIOB ) 60 » or - 15 •> Batter? factory vorxers, expostra gylOO al 1 6 ao-33 jc 1 2» » or - 1* \| b] Controls 9/100 al \| 1 lever eotor nerve conduction 1 velocities it exposed vorkets I HID; T5T1LS; BLOOD; DdTED KHGMB; \| imOBS SY.S1U DISSISSS; OCCOP1TXOIIL \| BIMBOS; IIDTJSTBII1 FLIRTS 1 a) 5.1 asole/1 \| rt-poi««ned cases 1 I 18-56 vr olda, iaiastrlal exposures. 1 I Ikooaiaal crasns, coastlpatica. 1 veiitiag. fatigue 1 I llll; IBID POI30H1G; iroosTBIU 1 tisiisis; HDdSTiin pcunnci; \| H100B; C1SI tKTOEItS; IOTOPSIBS; 1 tun: iiBitis; RITES: BSIII; iins; I Bin; iivn.; sons: OTXTXD nisooi; 1 icutTS; SMITH Biziaas i a) 12.0 » or - 9.6 I ) Oeenpationallv exposed nq/100 el \| 11 controls b) 27.8 « or - .• \| aq/100 el i 27-50 Tr olds, in storage battery I lannlacticlag plant. J8-»8 it old j ccatrols. 1 I Iicreaaed rates of abaormal I sttaphases vith ckronatid aberrations 1 in vitro. 1 1 HID; "Brits; CHWHOsoau 1 itinmoBs; ITU.T: HOOD; HEII.IH \| RlZtBDSs IVDHSTBZUi PLAVT5 ! I CCC««HIO«l BKI1DS; TOSUHT1O1 I iinsoiE; it vino miTsis I S.2 » or - 2.5 soyiOO \| values lower than generally nported. al \| Ineiaved, contani»ation-free aanpliag 1 t«c»»lqn« aad cheaical analysis 1 Tcoible factors. I I 7-10 vr old ehlldres. reaote area of I faBia lev Guinea 1 I eicco: me: anus: catmBEi; IE* i eoiiu; mill ISMS a) 112 ng/dl I a) Ca adalsslon b) 7 ag/dl \| t) 1 no after chelation therapy 1 1 23 yr old Japanese palater. 1 1 racial pallet, aild 1amdl.ce, 1 arioelaal colic 1 I iBcala, tiqh levels of arinary 1 Iclta-aaiaolevQllaic acid and 1 coiioporplvria. I ElOOO; Kit; LE1D POISOIIIG: BITllS; 1 Jini: puns: occvpitioiii BIZUIS 1 (I SIT PISH antatcs IcnbT, J.a.S. 1980 British Javn&l of laa.strinl Bediclae 37:133-10 Caapbell. B.C. Seattle, I.D. Elliott, E.I. SoldberQ, 1. Booce, B. t. Beevera, D.6. Tree, R. Archives of Environaental Bealth 3(»);«39-««J roral, I. Sciaee, i. BertaiTi, J.I. lleasio, L. Irchives of Inviionnental Bealth 35(3) : 139-16 Pool, C. SBythe, I.E. llpers, a. 1980 Science of the Total Eavlroneeat 15:17-2 Cblba, a. Toyoda. T. Inaba. I. Ogikara, K. Kicvchi, B. 1980 lev Saglaad Joaraal of Aellci ne 303 (8> : 59 ------- lead 7U9-42-1 « lt« 207.2. If 327. C, BP 1T0 C. v» 1.7T •• Bg »t 1000 C, 1 •• eg at 970 C, 10 mm Bg at 11«0 C fCOITXIOBD) MSS0E • 087 Blood •088 Iloo4 1089 Blood «090 ElOOl »posm not Ingestion Xngestion Insolation Ingmtios Inkalatlcm iBgeatloa Inaalatioa aiaiTTicu HBTHOD Isotope dilation IIS TO BBSS or CISES s 12 124 7 11IGB 0.15-0.33 ng/g 3.31-3. (6 miol/1 100-370 09/1 ) 38->120 ng/100 •! ) 90-120 09/100 ml ) 66-97 ug/100 il ) 61-102 ng/100 ml ) 57-61 ag/100 ll IBll \| 6Bml nrOBIHIOl \| lot given \| lefore and after 12-215 ng/day 1 («icl» ------- laad 739-92-1 ft ItB 207.2, Bt 327.* C, BP 170 C. TP 1.77 » Bg at 1000 C, 1 •• Bg at 970 C. 10 an Bg at 11CO C (COITIBHID) 1ISSBJ «0»1 Blood •092 Blood » 093 Blood IPOSOSB iOWB ngeation Ingestion Inhalation IBliniCll 8 IT BOO 1ST US BUB MB or cisss 38 38 w 19 ) 19 ) 28 371 MKS Bot gin Bot givea Bot givea Bot givea ) 11-58 «g/dl ) 11-126 09/41 a) Sot givea b) Bot glv«n c) Bot given d) Bot given o) Bot glvea BI1B \| GSBBBU IBPOBB1TIOB I 8IHEHCI I 1 1 1 1 1 1 1.91 * or - 0.66 \| •) (others IB h oases »ith lead cipes I flvood, J.C. aol/1 1 1 Children !• houses vita lead pipes I Thoaas, B. ) 2.01 ot - 0.63 I c) Bothers la houses with copper 1 Sheltany. R. •ol/l I tlpes 1 1978 I 0.67 » or - 0.23 1 d) Chillrsn In houses «lth ccpper I lancet aoVl 1 tipes 1 1(80781:1363-136* ) 0.93 * or - 0.81 1 1 aol/1 1 Bcther-ano-child pairs living la I 1 north valos d«r«lopBO&ts I I IIV1TS: CBI1DSII; BLOOD: COBMB1TITS I I iiiinnioBS: IEID: BIO»CCOBOI»IIO«: i I BBIBKII5 »»TIB \| 1 1 a) 16 ag/dl 1 a) Controls \| Haaaoad, P.B. b) 91 ag/dl I t) secoadarT lead saelter vorkaia I Leracc, S.I. 1 1 Gartsld. P.S. j 19-C Tr old «orkra, 21-63 TC old I Bananson, I.E. 1 coatrols. I Boda S.B. 1 1 Tonltes. I.e. 1 lettma reported 10» Incidents of I Johnson, 0.:. 1 aaurologlcal, gastrointestinal or 1 Pesce, l.J. \| ether aTBBtoaa. controls recocted 2* I 1980 \| aach lacldeats. 1 Jonrnal of Occupational \| ' I Dedlclae 22 (7) :«75-»8« I ElOOB: IBID; BIOIIBICITOBS: 1 \| IBCDSTtlll ellRTS; 1IDOSTBI11 1 \| PCIITTTOI; SBELTBHS; HBUTB EIZISDS; \| \| CCCDPHTIOmi BlIIBOS: \| j ClSTBOIBTBSTniL STSTSB; BBOBOLOGIC \| \| H1IPEST1TIOIS \| 1 1 1 1 a) 0.11 Bg t \| a) treated encepfcalopathy patleats I albert, B.B. b) 0.08 ag * \| c) Treated Pr-polsoalag patieats \| Shore. B.B. c) 0.07 Bg * \|c) Untreated sablects ultfc hlqh I Sayera, l.J. 1) 0.0* ag 5 I Hood, aloh ec In tooth Pb lerels I Strahlo, c. e) 0.0 ag * I a) Vatreated sab-teets tilth lo« blood, \| Inelp, l.J. Mdlaas I Hqh tooth PC levels \| Pastecnack, 3.5. I «) Untreated sabjects «lth 1m blood, I Tcledhoff. l.J. \| lev tooth Pb levels 1 Coras, F. 1 I Clalao, J.l. I Chi Urea In Pb register of BI City, 1 197a 1 iitlinqs of ceqlstcy cases and dental I Invironnental Health I clinic patients. Host «ere tlacX, 1 Perspectives 7:33-39 ( Cccn lo-lnccne fanilies, ages 5-15 \| 1 yi, n«a< 2.3 yr. I t 1 1 liqk incidence of psychological I 1 referrals and behavior pcoblena in I 1 a) , b) , c) . Convnlsioas in « j j catieats. a of 6 encephnlopathy j 1 patients nentally retarded, aoae j j diagacsed organic brain syndrone or 1 I aeizare disccders. \| 1 1 1 II1B; 1R11S: CHILDREB; IIB \| \| FOIHRTOB; BfB TO8K; SIT1L PCISOBIWC; \| \| KB1VIOB DISCSOBBS; BSTIBDITIOI; I \| E10CD; TEETH; P1IBTS I 1 1 (IEII PIGS) ------- lead It lt» 207.2, If 32). C. 8P 170 C, TP 1.17 aa Hg at 1000 C, 1 Ba 19 at 9TQ C, 10 u I 20 4 122 t TO 1 60 » MICE «) «-11 B«f k) 7-M 1191 c] 4C-64 agf 4) 37-S« B4 ») 3-2* og/IW Bl b\| 7-19 ag/lOO ml c) 6-20 og/100 ml 4) 5-37 09/100 si ) 7.0-26.5 ng/100 »1 1 2.3-37.1 ng/IOO el 7-».0 aaalA? MM i enttit, xiroiaiTioi t tsnREicE 1 1 i i a) 9 » or - 1 mgl I •) Control* t Baoharaa, S.8.T. b) 1» * or - 3 BO* \| n irposea. M tmleltr \| c«l»«, S.D. O S« » or - 3 >4« I e\| Erpomd. «r«Pt<»«tic ai< 1 Sonic, B.C. 4) »5 t or - • igX \| tlock«iel ii \| liTlroBMntal S»a«rch I teiiedtT I 22:2«»-270 I tcUnal rb (sac •!>« Pb la I I kmogloblB tiaetim. 10,000 n I 1 ttactloa, »mt tt»» d» \| 1 1 1 m-»po»d ladacUlal ork», g« I 1 25-«5 TT. tipaacd workers tro» Pb j 1 inltlni pl««t. \| 1 »ems«4 rlak of -toxlelty t lo« 1 1 blood Pb l««ls IB MTlwr* vitfc I 1 4l«i»lslL«4 caoacltl tot sntkuixlaq t I lev »lxc«lar «t Nt-Undin? protsio. I 1 t 1 ICOITS: U1D POISOIIKi BIOOI; \| 1 mosrnu einicift: ntsgtiRit r i CRICK; tint ineatsia. nam i 1 CCCDPIIIOIH 81Z1BB3 \| 1 1 1 t a] 10. S « or - 3.7 \| a) ratiats. 8«lb1 \| Cbildna'a BoipltU I DoiBaa, H.B. bl 11.1 « or - 3.0 t >> Sekool ckildna, B«lbo«ra«, IBB« I 1>80 •4/190 B! \| utocn \| B.dical Jonnal of c\| 11. + or - 3.5 \| e) Scaool children. St. Jtadrns, I listralla 2{C) :315-3t« •«/100 al 1 Mai-c««l »t«« [ i] 13.3 * or - S.5 Id) rrtCBool cttUraa, lelboora. I oq/100 B! 1 laa«r snbnrtg \| 1 TCBOa* SBBfllS i I IKvated Pb <> 25 aq/al\| In 10< of \| 1 Mlnoan* Fnschoalani if from pica. I 1 Era-school a»d •ekool-aoe c»ildr»B, I 1 StaU ot Tletocla, lB«tcalla I ( lOSTdlll; CniDEM; BLOOD; lltU; \| i Jioiccammoi; nsn utts; amis i i i I i 1 15.1 * or - 0.59 1 a) Controls ( lta«cjs. 8. 4/140 ml 1 t) tasidaxta ot point »4 area 1 Foals, 1. ) 1«.« « or - 0.90 I \| Bernard, a. 4/110 Bl 1 lean, ««an a«e (2.3 Tr, froa 1 Bacbet, J.p. S.S.) 1 Cd-pollated area ni4«>. tit 1 1»40 1 controls, »an aoe »1. 1 jrr, troa 1 International Ucblvas 1 ckatlarol. Ealqina. 1 of Occupational and 1 1 SaTlroBBeBtal BJealtb, 1 BLOOD; BLOOr PLtSSt; ISItti C1DSIM; [ (5:271-27* I Hip; XSSCVI1: ItKl SIHMS; SEtSIfff; I I let: KPotiTtoi sxposoiE; UDOSTEIH i 1 ICtWtlOl: SBBlTEtS; KIDVEI tISHSIS I 1 • 1 1 3 aaolAg 1 lad polsoiieq casea ! Iraki, s. edlan I I Banna, T. 1 24-59 rr old Japanese lead «orke» 1 Tanaglaara, 5. 1 1 oaxlo. I. 1 f«riptetal narre coa8»ctioi wlocilj I 1980 I I8C\| cornlatel vltt Blood Pb. BCT I International Icealrea I laproreaeBt after caelatioB IherapT. I cf Occupational and I I ZBTlronBeatal Maltb I 1110; B1OCO; POP01AWOS EIPOSTSt; 1 ««: 151-157 t CCCVPKIOIII tatnos: IBOBCICCIC i 1 fllHIESflTICU; aiTllS; LEIS t 1 PC1S01I16 \| 1 1 tlttt f kGt) ' ' ------- ft Jtl 207.2, RF 327.* C, BF 170 C, TP 1.77 u Bg at 1000 C. 1 » Vg at 970 C. tO •• Hg at 1160 C (COITIBVED) nssvs »098 Blood (099 Hood 4100 Blool 1101 Blood • 102 Blood IfOSOBS IOOTI ngestios: Ingestion Inhalation iiiimcii BBTBOD ix BS US us 1ST •OBBEB OF CUSS 00 ) 5 ) 1 a) 60 b) « cl 70 a) 32 b) 7 a) 22 b) 22 c) 10 11KB or - 60 09/100 al ) 0.17-0.25 09/9 ) 13.8-11.3 og/q a) 2.3-37.1 ng/100 »1 b) 6.2-28.7 ng/190 il c) 7.0-26.5 ng/100 al a) 1.0-2.7 uaol/1 b) 0.4-0. 8 uaol/1 a) lot given b) lot given ' c) lot given BBiB i entail nroiBiiioi i iBPiBEici 1 1 i i 1 1 ot applicable \| feaitlve correlation »Uh 1 roster, J.8. 1 environmental Pb soirees i lonria, D.B. 1 1 Stinson, I. I 9« black ana 6 Bispanic children I 179 I 1 Irchites of I less of appetite, nausea, I Znvironnental Health 1 constipation, nental retardation I 34(5) : 368-371 1 1 1 Brain damg* 1 1 1 \| III jnSIT; CRIID1S1; IBID PCISGlTIG: I I tIRll SETItClTIOl; HOOD; 1119; ) \| BR1LS \| 1 1 1 1 ) 0.19* ug/g 1 •) 10 and 210 days after tracer doses t Sablaovitz. 9. ) lot applicable I of 68-20* nq/day pins dietary intakes 1 Vetherill. G. 1 of 12-215 ng/day as nitrate. j Kopple, J. 1 treathing nn filtered air 80.7 of the 1 1975 I tiM and lead-filtered air 19.31 of 1 Proceedings. University I tbe tine 1 of aissovri Innaal I t) 0 and «0 days on air filtered to 1 conference on Trace 1 rcnove Pb. (49 yc old) . Back to 1 Substances in 1 initial level after 20 days breathing 1 InTirouental Health \| »fllter«d air. 1 9:361-368 1 1 I 8«althy 25-53 yr olds in netabolic 1 I vard. lo» Pb diet up to 6 no. 1 1 1 1 Tito: ICTUS; HIIJB&I. mTiioiisfl: i 1 H1I»: FKIS; BLOOD; 118 POIltJTIOI: \| I 01EH UI1S; 1D01TS: C01P1BITITI I I miomos; OISTS i i i I I a) 1>.9 ng/100 al 1 a) Residents of liege (lost polluted I Reels. B.I. b) 1».« ng/100 nl 1 area! 1 Lanwerys. B.B. e) 15.1 ng/100 al 1 t) lesidents of Bcassels (leas 1 Sachet. J-P Seonetrie j tellnted ar«a) I Bernard. 1. 1 c) Control area 1 1981 I R«ans and eunnlative freqaency I Environnental Besearch 1 distribution not aach different I 2»t 117- 130 I hctveea tbe three groups 1 1 1 1 8«altay snb^ects >60 yr old, I I residents of the sane areas 25 yr. I I Belgian 1 1 1 1 SIISIUI; iBDITS; let; BLOOD P11SB1; I 1 Ollit: CICHIHH: LtiO: BISCORI; 1 I BIT1LS; ZTIIC: tRDOSlBIJlL 1HISSIOHS; \| I IllOTtBTM tCL10tIO«: POPOlMIOt 1 I JIPCS08E; OBEII 4SBSS I 1 1 1 1 a) 1.6 anol/1 I a) sorters at Pb line 1 ttansen. J.P.B. b) 0.7 naol/1 I t) Controls I Dossing. B. 1 fstinated frcn graph 1 Pauley. P.-E. 1 1 161 1 Residents cf Greenland. 22-46 yr old. I Journal of Occupational 1 1 Bediclne 23(1):39-«3 1 GBizniii; » COLTS-. BLOOD; OEIII!: t 1 I!«B; OCCUPMIOlkL BlZlSDS; MHHIG \| t t 1 1 a) 2 ag/dl I a) Gout patients, no renal disease, I Batanan, T. b) 26 ug/dl I 1C had prior Pb exposure I naeeaka. J.K. c) 26 ug/dl I b) Gout patients, renal disease. 10 I Haddad, B. 1 had prior Pfc exposure \| ?epper. E. 1 c) Patients, renal disease, no gout, I landy, E. 1 ne Pb exposure I nedeen. B.P. 1 I 1981 1 32-78 yr old gout patients I Hew England Journal of 1 1 Bedicine SOU (9) : 520- 523 1 IE« JIES;i; » DOLTS; KIDRET DISE1SES; \| 1 EtCOD: HBIII; LE1D \| 1 1 (•in mot; ------- lead 7. 39-92-1 It It! 207.2. I? 327. C. BP 170 C. It 1.77 u Rg »t 1000 C. 1 ll Ig at 970 C, 10 u Bg at 1160 C (CORHHSO) TISSUE «103 BlOOd 10* BlOOd 105 Blood • 106 Blood, evils Bisoson BOW lagestioa Xaaalatloa Dersal IBlLRXCat 1 ETHOS US us us IU1BSS OF CISSS •I 8 b» «S 1) 88 b) 11* C) 31 4) 33 a) 30 b) 20 20 UKE t) 20-125 09/100 ll b) 22-80 ag/100 ml a) lot giv«B b) lot gi» c) lot gi»en d) lot giea a) tot gi?« b) lot giT«n a) 39-5» ag* b) 107-150 «gt c) 172-209 ag* d> 102-120 ng« SUB a) lot giT«i b) lot gi'ea a) 180.0 ag/1 b) 268.* og/1 e) 668.3 ng/1 d) 818.1 ag/1 a) 25.* * or - 12/1 ao/109 ll b) 17.8 « or - «.9 oij/100 al a) 46 » or - 3 uq« b> 130 » or - 8 og* c) 193 * or - 7 ug« d) 110 * or - 3 og* (S.8. ) ei»ui irroiaiTioi a) lortars aipoaad at least 1 re b) (octors pnTioaslT upoMd > * ji, >ot exposed (or 12 or »or« » prior to t«ir. it BITS; Biooo: DHR: ma: CCCOP1IIOIJ1 H1I1BB3 a) Oat»«rsiti atadtnts, esploTeas t) workers, steel ladistrr c) lorkers, battery factory d) lorkers, secoadarr Pb sielter 17-63 yr old Caucasians caiiBi; loons: BLOOD: SUITI; w 1ITO IULTSIS; HID: NR11S; OCCtJPlTIOIH BUMDS: SBE1TBJS a) HeatallT retarded ekildrca b) Coatrols Erobablllty ef aeatal retardation iaereased h« Pb exceeded 800 vg/1 later. 2-5 yr olds. me: inns: oiimcHs vim: cnufsi; ititii BBTUUTioi; BEHTB CI!»OS a) Coatrols t) Bxposed, BO toxtcity c) Exposed, syaptoaatic and tiocheaical crid«nc« of toxicity d) Exposed* syaptoas suggesting toxicity Icn-«x!>ose3 industrial vorkers, ages 2!-S yr. Zxposed vorkers froa Pb saeltiag plaat. lacreased risk of toxicity at lov blood Pb leTels IB workers vltb lisinished capacity for syBtheslziag lev solecvlar «t Pb-biadiag protein. DOITS; HID POISOIIIS: BLOOD; ivosniti BE0ICIWZ; T.IID-. IIDOSTBUI I1RS; OCCOPtTIOIlI a»Z«BOS 1EFEIEICB llessio. I. Castolli, H.B. nonelli. o. Toffoletto, r. Zoccketti, C. 197» iBternational ucUves of Occupational and EBTlroaaental Health ««:127-132 P'aa, l.T.S. 1981 Joornal of Toxicology aad laflroBBeBtal Health 7:273-280 Seattle, ».D. Hoore, B. B. Goldberg, 1. Finlayson. 8.J.W. Backie, B.a. Grakaa, J.F. Bain, J.C. RcLarea, 0. t. Rardoek, B. R. Stewart, G.T. 1975 lancet 1 (7907) s 5 89-592 Bagnavaa, S.B.V. CalTer, BlD. Gonick, B.C. 1980 ZoTiroaaental Research 22:2«-270 (Htt P»SB) oo ------- l«aot 9l«* b) lot gl«B mi i GIIIIU urotamoi i nnisicz I i « i I i 2310 ng/100 al I it Coitcol 1 Taccaro. S. •8.3 M/100 1 1 ) OccipatioaallT expoeed te about 1 \| Barakigiaii, C. I ig/cm • list with J.7-12.»» Fk 1 Coloibcttl. 6. j itTtkroeyt** 1 Incl, r. 1 I lol, l.B. \| Itlllil factorr MCk«rsl HMD f PiqqUco, T.I. \| «ipo»»r« tii« of ».« yr I paqxno, 5, 1 j Tola, 8. \| Io4«tmt« to MT«C« litabolic •ffccti 1 1)80 I tm »0t of «ifos«4 «ar1mrs. 1 Iit«r»«tioiwl ircklT«s j I of Occupation! and I IULT; 19tHlS; 1MB !O1SOII6: BETal I BnlcoBMBtal Health \| TOISOniS; CCCTPitTOKl DISUSES; t »S:35-»« \| ROOD; OIII1; COSMtltlTB \| 1 imomois; IIDOSIJIH ncini: i 1 iiisniam nnogs; I.SIDJ units: i \| CIST: HalTB UZ1IDS; I1DOSI1H1 I ) IT90STHIIIS; nilUTIOIi OCCffP»TIOIIl \| I llIMtS \| 1 1 I 1 ) ««.53 ng/dl 1 a) 111 etlllna I Sos«n, 3.1. 1 7» or - t (SI) 1 k) 12 ckliaco vitk initial ft levels I CkesMT, ».»• g/«l \| > 60 n/ai I Baistci, k. 1 21 » or - » «St) \| c\| IV* 12 ekiUrett in b) aft«r I Detuca, B.r. V41 t ckelitloB tk«npi t Bekatfey, K.I. I I 1»80 I 1-S it oil. IT. I lev I»9.1»4 ]o«rul of 1 I «aici»« 1 »»; TITUII 0; CBIIDNI: in VIE; 1 302(20) :1128-1131 I E10CD; COBMUTITI ITHff»TIO»S: BLOOD I I SJttJIt! NCtlBCtlSl; RRIBOintS: 1 1 BtnoncnoiiMiciRioLS i 1 1 1 t 166 ug/1 I le-oce«pitiaullr exvonl. I lTgo»i«, E. B. 1 1 Boll«ba: i 2«(ioiti«i3-i«ia 1 CC«\|lt>TXlI nilOKIWIS; KIISDIHSIT I 1 BIHODS; llICi OCCUPUIOVal UCUDS 1 t t 1 1 32 of dose 1 take, aftec -eea 1«D4 expense* of I Borrow, P.I. 1 130 pq PbClJ u 0.26 n acrogol or \| Beltsc, H. 1 11.54 <« fb(C8)2 • 0.24 « iwoaol. I Into, r. 1 S«ak tlie 2019 «i». IstiMted blood ) Sibt, r.E. I »clie 6f boil «t. 1 180 1 1 CBTiraiMititl B«9«atck I 20-56 Tt old, SS.0-95.4 kij. Bo 4 21:373-38* I kltoCT of talaoiarr tis»«. j 1 1 \| II»D; UKSi COBNtlTITB BTttOaTKIS; I I HOOD; inumoi: in ?oiimoi: i 1 tMsaumn imoas; IDTITS; m TOBK i i i 1 l a) 16 * or - TV \| •) Sb1eet »itk Bocaal re alsocptioa I »at»o», i.s. t} 47 * or - IK \| aa » feiritie. InelB 1 Una, 1. 1 t) S«b1act tltb klgk Pe absocptioi I floor. t.B. \| «»a nbnoiaal aene I«rriti». t 198« \| Significant fosltln eorrelatio I taacet 2(8188) :23«-237 1 t«t«*> oral Pb aid F« absocption. j 1 35-70 TT old. Halted Kiaadot. 9 I 1 patients »itk chroalc blood loss, j j taaipareii, or TevemctioB tor I I secoBdarf polfcytkeeia. 1 CTaal I j tlcgfl daioc. j 1 ( I oinr? itlisccB; BLOOD SOURJ BOB»: i 1 tlOICCQIWHTIOl; lETIBOLISB; II TITO 1 \| III1TSIS: ltd; LHB I 1 < tun MGQ v£> ------- lead 7US-92-1 ft It? 207.2, ft 327.* C, BP 17«0 C, T? 1.77 aa Bq at 1000 C. 1 aa 89 at 970 C. 10 mm Hg at I ISO C (COItlmtD) 1ISSOI •112 BOM • 113 ton* »m Ben «115 Sral* UPOSOBS TOOII IBU.TTICU IZTHOD US I-r»r spcctroi Elec troche • Elec trochee WBJJB OF C1SES »> «2 b) S3 O 1» 22 1 11IGE ) 1>21« PS* b) 11-13* Fpe e) 0.3-15 ppa 15t> rt 20-11* lj/9 •) lot «if«« b) lot gi»«n c) lot git en ) lot oi»«B lot gl»e« mi i eiiiBii XMoiBHXoi i tcnmcx I I i i ) 72 or - 40 ppa 1 •) Black adqlts 1 B»* (27-75 yr oil) at I 1980 I storage battatT plant. I British Journal o* 1 1 Industrial ledlclne I SIMM: BlOOt; BOtTS; n TITO I 37:109-113 1 1II1TSIS; LI1D: IR1U; IICOETBIil 1 \| [HITS; OCCOPITIOMIL MUSDS; \| I PCPSUTIOI 1IPOSBB! \| 1 1 1 1 a) 136.05 noyg dry lit I a) lib I Caipbell, B.C. b) 3T.50 ag/g dry »t 1 t) calraclii { Beattla, l.B. e) 163.33 ag/g drr "t 1 e> Stera<» I Elliott, S.I. 1 Utopsy saiples f Coldbarg, 1. 1 r Roore, B.S. 1 3« JT alt aetal buraer, ecposel \| Bearers, S.S. 1 4«ring a building 4«Mlltloa 3 ao t Tree, H. t earlier. Killed la industrial I 1479 1 accident. t JrcKiTes ot 1 \| ZaTlronaental Health I Ibdoalaal craapa, coBStipation. \| 3» () : >39-«»3 1 foaitlng, f»tigne ( 1 1 1 1111; KID IOI50III6; IHDtJSTKUl 1 \| CISElStSi IIBBSTHll POLLOtlCI; 1 I E10CO: CIS! tlSTOSISS; ITtOPSIIS; \| 1 8I1BT: MDins: »ra»B?: aau: MILS: i 1 BUS! IITEE; BOIES; OIITED KIIGCOS; 1 \| 1CVITS; BtlltB EIUIDS I 1 1 t 1 ) 0.99 ug/g dry «t I a) coctet I Caapbell, B.C. I I. 10 ng/g drr «t 1 t) Stei I Seattle. l.D. I IgtonsT saaples \| Elliott, B.I. 1 I eoldberg, ». I 3* yr old aetal cocacr. eipoael I Boors, B.B. \| dicing a baildiag deaolltloi 3 ao 1 Beerer. D.5. I earllert Killed U industrial I Tree, 1. I accident. ( 1979 1 1 Ircbivas of 1 lMol»l craaps. coutlpatlon. 1 Eariraaaeatal Health 1 .eiiting, fatlqiej \| 3»(6) :»39-»»3 1 1 1 mo: IEID tcisoiiiG; ISDDSTSIIL i 1 EISI1SI5; IIBOsnilI PCllonci; I 1 cioci: cist iisroiiBs; imopsirs: i t met: iiBiiis; nTES; BIIII; tins: i \| IIII: 11 TIP 5 90115; OIITED CTIGDOB; I I ItOlTS; 9II11B BlItSDS \| 1 1 (»1II MSB) oo o ------- 7«»-92-1 Fb Itl 207.1, el 327. C. BP IT«0 C. T» T.7T » B« «t 10011 C. 1 •• Eg at 970 C, It u 14 at 1160 C (COIfXRTOD) HSSfS 1116 Braia • 117 treatk 1118 8ratk • 119 •air IKS1SI BORE Inhalation Inhalation Hitmen. BET BOB US PIXB Mil US I08.EES OF CIStS 1 1 a) 31 b\| 22 MISI 0.051-0.152 ag/g 0.012-0.050 ag/g 0.059-0.112 ag/g < 0.010-0.018 ag/g O.oat-0.183 ag/g < 0.008-0.026 ag/g •at wt 99-0.03 ag/ca a not giTaa a) tot given b) lot given (III Bill \| SIIIS1L IlTOtSaTIOl 1 1 0.067 ag/g 1 •! City ccsltenta. ioaar floors. 0.039 «g/g I total Pb, 8 nb-]ecta 0.087 ag/g I tl City realdents, lover floors. 0.011 ag/g 1 trlsUtyl Pb, 8 ssbjecta 0.07S ag/g I e] city reaidents. apper floors. 0.011 ag/g I total Pb. aablecta at vt 1 <) CltT resident, appar fleers. Mdiaas I trialkyl Pb, a subject. j <> Sifearbs, village residents, total I Pa, 10 sablects I fl SBBarbs, village residents. I triaUyl Pb, 10 aob-lects \| Decreasing it levela vitn increasing I age (P < 0.05) 1 1 latopsies. lesideata of Copenhagen, ( ita stbarba, aad of vlllaqsa oa I Zealaal. lq«s 12-S» vr. 1 \| finall: 1BDUS; 1DTOPSIIS; cRluni; I EMIR; in poiLtrtioi: \| E10aCC9fl9UTlaa: 01BII UE1S; LIIB I C1SUIC COHCOIDS 1 1 lot glvea 1 liter aatoaotlve Pb fcalide aerosol I eipoaara. levels a finctlon of \| particle size. Zstiaated fro a graph. I TUal valaae of about 900 ca s ant 1 riselntorT freqaeacT «f 15 1 cvcles/iin salatalnei during 10-ain 1 aaipllag tiae. 1 \| IStlTH; ISORKB: CaLCIOIl; C BIO SIS!; i mi: 17TOBOTHI: ttmspsni; 1 PIBlICOUtTS 1 1 6.6 ng 11 saapled at rate of 1 Vela. 2-10 1 aln after earalag 8 arc mldlag rods. 1 I«ar detect lea liait. 1 1 aai.wcsi.tT pvysics shop, Florida 1 I noBioi: moils; BBIKB: ULCIOR; 1 CStOSnP,; CIBORXDR: COIPBR; X10R; I IlIC; 1M6IIISE; nCKII; TOT1SSIOR; I suirira: Titinm; THioroB; me; IIB 1 ecttntOI; f«8ES; IlOfSTBIlL 1 iTHospHies: met nsntrs i I a) 23 ppa 1 a) learaiag disabled b) a ppa \| b) Controls 1 1 leaniag ditableS and aoraal 3rd and 1 «tt grade atadents in Canada. 1 CltCIT: RietSSIOR; POTASSIOR; I SO CIOS; CltHIDR] COIUT; COPKB; 1 Itoi; !.«»; auetiESt: zxic; 1 eetCBH: iitnoR; uncoar: RETILS; 1 HilB; CSI1DBII; CltlDl I Past) ttriiegct i«lsen, T. JeBsea, K.I. Grandlean, p. 1978 tatare 273(571) :«02-C03 D«saedel«er, E.G. llBCkester, J.V. EBVlroaaeatal Scleace and Techaologj 9 (101 j 971-972 ItselssoB. K.B. Desaedeleer, G.6. Johansson, T.B, VLacheBter, J. R. 1«78 IBaals of Occnpatioaal Rygieae 19:225-238 VU1, 8.0. prkee, a. 1977 Science 1«at«13) :20»-20« ------- Pt 1W 207.2, B« 327.4 c, IP 1T»0 C, TP 1.77 HI Bg at 1000 C. 1 •• Bg at 970 c. 10 •• (g at 11«» C (canntmi TISSUE Bali 4121 •ait • 122 Bate 4123 la It iiposni ton ItUTtlClt ffXTBOD 1ST US ElaCtCOCkai •unit or cisss t aj 45 hi 70 cj 4 a) 65 mei 1.S3-7.«T BS/J a) 15.3-19.7 «g/g b) 19.3-59.< •«/» c) 13.9-16.9 OJ/J 1) 4.0-13.7 afl/g at gt»«o Sill \| SEIM1I IBTOMITIOW \| BBPIBICt 1 1 1 1 1 liTl«. 24 ncnswatatln 1 CLlttlebanagh., S. 1 tt«-4uL\|lla tr«atsj««t« are I 1980 1 tabla.t4. Ik fvastblU.tr of a I sci«aca of the Total 1 koltstle, ao-vask palter for latr 1 CailronwM It: 53-75 1 «a»lTHs Is oatliaei aid supported. \| 1 1 i iiritt; met IZMKHS; tins i I losnuii; BasotKBiir BETHOIS; \ \ enusi pMTFiist coBptimn t I iTiiniiois; itoBjioa: IRIKHI; i 1 iBsnic; sum: BBOSTW; cumim; i 1 C11CI9B; CnCBtlB; CBOBXOB; COBI1T; 1 I copptit siitrui: sminus: GOLD; i \| tOBUB; ItOB; IltTSITOS; Hit; \| i Rie«Bsimt Bueaitsi; SIICHBI; i i ectiBHim; ixcKn: PHOSPEOBBS; i I EOTissm: siBiDimfi SttMiosj i I siiicai; SIZIBS: soong; sisciiniB: t 1 Sturm ; TIB; TltkWIOB; TVBGStBf; \| 1 n»c: Tiicoiiffe i 1 1 1 1 ».»0 » or - 1.33 ag/i I Jaacd kaic - 10 «k perlofl. BailT I Chtttlcboroagb. S. I «OM« Of 100-300 K <•• 29 \| Steal. B.J. I aatoralaatteis. t 1980 t t Scioaca of the Total I lajittalla \| EaTicoaMat 15:25-35 I iDsranii; em; GOHTLMHTZ i 1 ITltaitrors; c»»n»s; coritB; itttt; I I Bitus: tsici it tains; tuc i i i 1 1 a) 2».S ng/g \| a) Bales. las laoales I Johnson, D. B. b) 29.0 tg/a \| t) T«aalas, lo« Inqalcc \| Pravast, 1.1. e) IS. 1 cj/a \| c) Bales, laacastar I Tillecj, J. B. 3) 9.8 ng/9 1 at Maalas, laacaster \| caaau, D.E. Seatetclc a«a>a i lt«as Uffcni p«.OD1. Talaes for \| Bosaafaia, J.H. 1 loag katr. \| 197C 1 1 EP-600/t-7«-019, 235 1 tniLS; niimi; piuitiaB; Lsio: i pp. I lopratTtoi Eiposmx; OCCOPITIO»IL i 1 nztsis; cturosni: IWOPSXIS; i I ttooo; viiiETS: Sfiinr: BUS; naivi; i I tSiCS; TCSCUS; 1MPOS! TZ5SIX; I I IITW; CONPlUTtTt IT«ltJlTIO«S; R1 1 I JE1SET; Ckllll; SHIBS; IBTOBOTITI I 1 1 1 1 45.17 tg/t»T: si CUTS: IESTES; BULXB: mis; i 1 B»IB; llfEt; MIES; OHIID mSOOH; \| 1 ItDLTS; BCU1I BUklDS \| 1 1 00 ------- Had 7««-S2-1 tt Itl 207.2, It 327. C. BF 1740 C. » 1.77 •• B? at 1000 C. 1 •• Hg «t »7« c, 10 •• «« at 11C4 c 1ISSIB ««« l«ir «12S Baart MM (IdMT KfOSVBE BOMB UURICll BRBOD Elctcocha US BOBBIE or CUB 1 •1 »2 b\| SC C\| 11 •IKS lot 9iT«a «) 1S-2W p;i b> 15-10* ppa C] 1.«-7« ppa Isk vt •III \| 6BBIBIL IirOIBlTIOl 1 I \| 1 ml« of trorld lltentac* OB tha 1 acc«»al«tloa ad biaoracatra^iai of t Ml«ett toxic tr»c« >«t«la i» Vi»« I litt til vail »md ottet laiullu \| lli, fmr. ••!!•> cl«« Dd boot. t l»l»l»t«4 bi 9«oqrapUc »r«t. j ««b-}«ct3, ami, «4. «xpo«c« I gc«Umt, a>U.TM la pp«, an* t itkoEitr £«• OT« OO E«f«c«aora. I 1 mictj lasiuut: ciiuta; cnrui I itinci; tJMH: nons wst: in \| Illlin; SOUTB IBEBICI; SODtBBiST I Jill; DIKZD HTCDOI: OflllD STITIS; 1 itii: vuis; mm; iirnoit; 1 iismc; toieis cwmii: cnmni; 1 COIllTi COHM; 1UB; (1I8COSI: I 1ICRI; SfLJIIOB: Tlli T1HOCTS; til I lomrtToi: iiiRiL ?ointnio«s; I cioiccvniMioi: BIOIIBICITOBS; L«B 1 loiiotioi; ro?otiTio» tiMsnsE: urn 1 tctLtmow: TUCI nMiirs; ait its i 3,90 09/9 dry t I latopST •••(!• 1 1 36 ji oil Mttl tm«c, «iiK«ea 1 avclio, a b«lldlm« lawlltloi 3 «o 1 «atU«c. 11114 in liflvstiial I ioeUat. 1 1 ItJoBltal ccacps. co««tip»tioii. 1 Kiitlag. fating* 1 1 me: u» icisonie: iiDustint i nsnsts; iitnnut eu.0»c>; 1 HOOB; CIS? CISTOBIIS: ITCOPSIIS: \| IllBTj SIDltTS; IEBTES; BBIIB; ItlLS; 1 But: itiis; BOIES; mmiD moron; I ItntS; BUI1B BIU1I1 a) 52 » oc - »7 ffm I a) Hack a««lt b) 3« » oc - »» pp« 1 t) Caneailai •Salts e) 26 » oc - 23 FP« 1 e\| Ckllitn Mb »t \| 1 latopalM fcoa hospitals It Roctfc aid 1 Seat* Cacoliaa. Blacks and 1 CnetaUM. Idalta. a«« 1«-91 re. 1 Ctilliea, agai t day»-t it. 1 MTIT.S-. SOUS; LITEt: SToaitS: 1 ItfflTS; CBTlDBf; CIDHOR3 IMC; 1 UK; BOITB CUOlIIl; SOall CMOLII1; 1 IBTOPSISS: BIOiCCBHBLlTIOi; BlCIlt 1 S1VCTBS; IOB; SIWKIIS; TOtlCCOSi SBI: I iconuM i (HIT »l«t) BE7BBBICE JoakiBS. B.I. 1»79 FPI-600/»-79-fl«9. ISk PP. Caapbell, B.C. (•attle, 1.0. Elliott, B.I. «oldbac«. 1. Soote. S.B. Bvwreca, D.s. TE««V H. nn Ir eh lies of EaTiraDMOttl Etoaltk 3«(S)t«»-»»3 Raaaer, D.I. Caloccl, ».T. BaMolblad. T. (llllaas, I.E. Plakecsom, c. 1«73 Joacaal of Oceopatlooal Hadlclne 15(12) :56-1«3 OO U) ------- lead 739-92-1 Efc >t« 207.2. Bt 327.» C, Bf 17«0 c, It 1.77 u Ho, at 1000 C, 1 m B«. at 970 C, Iff a* H9 at WO C tISSOl »127 Kidner »128 Kidney «W9 Iver EIPOSOBE BOOJ alliniCal BET80D its Electroehen US •OTBSB or USES a) 9 ») 9 e) 11 1 > «o ) 60 ct 1» MRGE a) 0.10-9. £0 ag/g b} 0.15-0. «» ag/g c) 0.0093-6.70 ng/g let vt lot given ) 15-517 ppa ) 15-785 ppa ) 0.7- 1ST IPS sh «t an* i SEIIBIL iiroBaaTioi 1 1 1 a) 0.23 ng/g I a) Controls b) 0.34 ag/g I fe) Barker group I c) a. 29 ag/g I e) Barker areap II let vt \| Bed la us ( teceasad refinery and anelter 1 eorkers, agea 55-76 rr. exposed to j keaTy aetals 1-3 decades. liac I ketveen retirement and death 0-1.5 yr I In group I aad 2-19 rr, group II. I Controls, ag«s (3-72 rr. iho lived 50 1 ki froa the factory. S«ed«n. t 1 SUCK; ClOaTIBS; KIDfETS; LITSB; I tClSS; COBPIBaim ETLlBaTIOBS; \| IIDOSTIIlt 115IEII; RaSOSZIER I tir sorts: immni: ustiic: CIDBIDB; 1 C1SIDB; CBI09IOH; COBUT; COPPEI; 1 eoie; iioi; IUTBIBUB: LED; I MieiiESE; BiscvET: •oiraoEWB; 1 IEOSPBOSOS; BOB IBM »: SC1SDIHB: 1 SIlEltm; SI1TIB: TIB; TdlGSTEl; 1 ziic: BEaiTH airiBDS: iroasTEiu 1 flittS; SBIltEBS; TELIHSIOB 1 1 2. »8 ag/g dry vt \| lutopsr saaple 1 1 3< yr old utal turner, exposed ( daring a building deaolltlot 3 ao I earlier. Killed In Industrial 1 accident. 1 1 Itdoalnal ccanp, constipation. 1 Tcilttna, fatlgaa 1 1 I tit: ma POisoiifG; iioosTEliL t cisnsES: IIDISTBIII POU.DIICH; I EtOOP: CISt BISTOBIIS; aOTOPSIES; 1 BEHT; KIDBirS: (EITES; BEIII: B1IIS; 1 Bait; 1ITEB; BOIES; 01IITID KIBGDOB; 1 ICOltS; BEalTH BlZltBS a) 96 « or - 108 ppa I a] Black adilts b) 69 * or - 11* ppa 1 b\| Caucasian adalts O «» » or - «S ppa \| c) Children sh at 1 1 latopsies froa hospitals in north and 1 «o«k Carolina. Slacks anJ 1 Caeeaslaas. Halts, ages K-91 yr. 1 Children, aaca % da fa- 6 rr. 1 I cims; BOIES; LITER: nniETS: 1 HDITS; CBUCBEIi C»D«n3; ZIBC: 1 U»D: mm CUOLIH: SOOTB cieotiri: 1 aVTOPSRS; PIOICCTB011TIOS; IKIaL 1 JTOCIfS; a«Zj SBoniG; TOBICCOS; SEIj i itonisBS i lEniERCE Brane. D. Bordberg, G. •ester, P.O. 19BO Science of the Total Environment 1C: 13-35 Canpbell, S.C. Seattle, I.D. Elliott, B.I. Goldberg, a. Boore, «.B. Beevers, D.S. Tree, R. U79 lEchires of Eariroaaental Health 3«(«):«39-»W Banner, D.I. Caloeci. 1.1. BasselBlad, T. Billiaas. B.C. Plakeraoe, C. 973 Jonraal of Occepatlonal eliciae 15(12) : 9W-963 (MIT P1S1) 03 ------- lead 759-92-1 n It* 207.2, n 327.* C, BP 170 C. TP 1.TT M Sg at 10OO C. 1 u Hg at 470 C. 10 » tg at 1160 C tconn HID) tissm «3« Itnr • 131 Livec •132 lomg iirosnx IOOIB IBlLtnCll mffoo us Electrockei IIS •OBBE1 or CISBS ) B 1 9 e) 10 1 a\| B b\| 9 d 10 B1IGI ) 0.21-0. 55 89/4 ) 0.39-1.0 ag/g 1 0.28-0. «« g/? Set It lot given a) 0.004-0.17 nj/g b) 0.13-0. CC ng/g C) 0.07S-0.32 19/9 let lit •til \| 6IHML HTOSBinOI 1 1 ) 0.211 ig/9 \| a) Coitcols ) 0.63 ag/g \| t) Worker group I c) 0.36 «g/g \| e) torter grotp II let wt \| Bedlams I teceu} nflnerf a>4 saeltet 1 »cfltet«, a«e« 55-76 jr. erpo«el to 1 >taT Mtali 1-3 t \| Xediams \| teeeased refimeCT amd melter 1 motkecs. aq«« 55-76 yr, vxpoaed to 1 ktaT metals 1-3 decades, time 1 h«tmm Mtlcememt ami deatk 0-1.5 TX 1 1m gromv I amd 2-19 yr. group n. 1 Ccmtrols. aqem 13-72 rr, >he lived 50 1 ki from the factaxr. Svedem. 1 1 sttiti: cuivns: RIHBTS: HTSR; 1 IDIGS; COBPIBITIW miniTIOBS; I IIDDSTRIH 1I«Itn; HSISOBEBEUT 1 Bmoss; iBTMoit: msraic: cuaios; 1 cism; cuBOBioB; COBUT; coppst; 1 ooto; »oi; iMtuiOH: HID: I fiieiiisi; aiBOJBT: MiTSDium; I fBCSPBO«!lS; BSBIDIO": SClIDlni; \| Sflt«I ------- l«ad 139-92-1 fb atl 107.2, II 321.» C, BP 170 C, T* 1.71 u lg at 1000 C. 1 aa Sg at 970 C, 10 ae Eg at t1«0 C nssm •133 1.14 «13« (all «13S i«ii «IM ••m IXMSIIB tan labalatiaa 1 uitmcu. BBTBOD ladloMtri Ilectrockea nectroclea » «-7I pg b) »-S a« lot glTea t given mi i 62 HIM ZEroiimoc i HFEIEICZ i i i i »1 30 pg \| •) Ifter 23 Mcacol lepositloB of \| larro. P.E. b) 3 «g I carrier-free PbCW labelled «ltb I Belter, B. 1 »203 \| tuto, F. \| t) Ifter 26* aerosol deposition of \| «ibb, r,B. 1 f 1203- labelled ?b(OI)2 \| 1910 1 Fictlcl* «iw. SS4B 0.2? » \| CericaiMBtal Sewarck t >««• r»«plr«torr b«m« of tt>2O3, 1.1 \| 21:313-38* 1 iCi U a) and t.« tCi i»'b\|. \| I I 1 20-5* it ol4«, S5.0-9S.4 k«. no I 1 biatocr of palMncr aiMin. \| 1 1 _ i mat wiss: comtinn ITIIO»TIO»S; i • t IIOOBJ tniiinoi; in toumoi; t 1 (lASOTtHEK IRBODS; « OBITS; IEI TOSS \| 59, 5» o»/j Ory >t I litep«T 1 Cupbvll. B.C. 1 1 Mattl. l.D. 1 I« TT Oil Mtll feWBCC, •XPOMI \| Elliott, E.I. 1 tltUt a bvlUi«« a«olttloi 3 M I 6ollb«rg. 1. 1 «acli«r. Kilted tm iiJutciil I loon, I.I. 1 icclteit. \| BMT«». 0.5. t 1 Tree. B. 1 Ibtoeiul ecups. coutipatlo. I 19T9 1 loaltlia. fatiam \| irchl«8 of 1 1 tB»iroB»e«t«l Health 1 met mo rcisoins: mosniu i 3a\|6u»39-««3 1 cxsMSES: iierartiii POILOTIC»: i t HooBi cisi nsTonis; »oroest«j; i 1 HUT: (loins; nuns; aim: nits: i 1 IHI; UTEl: BOIES; VIITIB MISDOI; I 1 ItVlTS; BE1III BlZlIVS 1 1 \| I \| t 1 r«ri«* af rorld llt«r«tor« o* ttt I Jttkltt, I.». I aecualatioa a«d bloeaioeBtratioB of I 119 1 s«l«et«i toxic trace i«tal« la KUB I Eri-COO/«-79-0». 18* I kiic a>4 Milt t>4 otker MmBaliaB t PP. I hale, far, mil, cUva tad boots. I 1 Tit»l«t«« br vcoorapble area, 1 1 aablects. ei. a«, expomra I 1 ara41at, aailravs la pp», aid I 1 tatboritT ftci over MO refermca. I 1 I I «mc»: ivsTiu.ii; CUIDI; cmiu i I iiiiicij CT»CTt; irtim.i cast; m i I tium; SOBTB usiict: sonnasT i I ISIl; »nD IIISDOI; OKTlt ST1TIS; 1 I tut; tans; BtriCT: atriBon; t i iisEsic; soicij cunn9i cncnim; 1 1 ccsiti: ccprii: LHO; Biscni; ( i iicm: sntinR: HI; THIOHHJ ui i i icttotioi; imu MraLiTiais: i \| BieiCCimtlTIOfl STOTICTCltOK; till I 1 tcumai; porounci BIPOSHII; IITR I \| fCltintOI; TUCE ItMIITS; BET1IS I 1 1 .« ag/} drr it 1 l«tcp«T aipl«. pettpkeral »«r»e \| Caapball. B.C. 1 \| I«»tti«, 1.0. I 3C TC oil Bttal tittaec, expoMl I ClUott, I.I. I 4»U« a bnlUlaq AMolltloi 3 mo \| Goldberg. 1. I earlier. Killed IB ladwtrlal I Hoore, B.t. 1 aceldmt. I Beever, O.G. i 1 Tree, 8. 1 Itdevlul ctaipa. eoaatipatioa, 1 1979 1 tcaitiaq, fatiiM I Ircklvu of 1 1 EBTlronMtal Healta I HID; mo MISOIITC: iionsniiL i 3«(«):«9-«»3 t cisMsts; mgstitii pounioi: i \| IIOOI: CISC HSTOtlEJ; IOTOPSISS: I 1 inn: Ktvins: IHTM: etui: »iis; t \| lilt: UTtB; BOIES; H1ITID ttlGBOS; I \| I1I11S; K1H( UUCDS \| I 1 (•in ts«t oo ------- I«a4 ft Itf 207. 2, «P 327. C. It 179 C, ?P 1.T7 •• •« at 100» C, t •• lg «t 97« C. 10 n If at tlSO C «««•» • 137 Sall»a ,„, Srlaal eoct 1139 TMtb ««0 Math irosvti toata _ lakalatlo Ig«tio» lakalatloa klltmCaL BCTHI US J-ral spectra* US us nnn OF CaSBS at 11* 31 33 ) 7 b» 12 . al 37 b) 323 cl 690 11 597 •t M 371 •net lot glv«n lot gl»«a lot gliea lot gi»ea 1 11.2-113.0 ag/g 1 C.1-3I.C ag/g Brj «t a) lot giro bl lot given c) lot given a) lot given •1 lot given a) lot glraa b) lot given c) lot give, d) lot given •I lot gt«a Uf 1 Canm irVOtltnOW 1 1 1 1 «J.2 «g/l \| b) totter, teel ladaxtry I 94C.3 »g/l I el aorken, battery factory I 2220. S ag/1 I d) corker* . ncortary Pb aaelter ^ i 17-C3 yr oia caacaalua 1 \| ClllBk; a WITS: BLOCB; SUIVl; n I TITO imisiS! KID: HTHS; \| CCCOPKlOIll Bit UBS; g«LTC>S t a] J0.7 « or - 36.7 I at lotoc aaacoa OlMaat patlaat* •g/g \| bl Coattoli b) 1». S * or - a.7 \| Imtral kotn tlainc, aatopa) ag/g I Dry at I f atUata aial of ayotropkic lateral I clarol* aa< progr«aalT« aucmlar I attopby, a«a* aq«. 58. « » or - 13. 1 I ft- Cottnli 4i«l of yaclona 1 aiaaaM* at C0.9 « or - 11.1 yr. 1 mis: isoiTS; konmisi \| ItUtOSTSCOUS DXSIaSIS; Smal OOBV; 1 iiokccnmitioi: cticias: coppst: \| HOli HID; IU6UESI] SITU.S-. \| SttBVlQBs X1IC 1 a\| t.77 ag/g dry « \| 1} Boyi. lr«l 1 b\| 4.9* «g/g 4ty «t I t\| 61rl«, Itaa k c\| «.»7 09/9 dry wt 1 e\| Ban aad girl. Ina 1 41 .92 ag/g dry «t 1 t\ ChlUcea Uvlag 1m kcea I slaeaj «) 3.0* ag/g dry «t 1 ilrth 1 c) chlldrca. ar«a a t Ina 1. kcavilT Udntr'lallnd city. I IMB S. aabacban/raral area 1 Coacmtr at to* lacraamd vltfc ag«. 1 ».6VTt. 1 1 Qaraas ?-T2 yr olii. llvlag la 1 BalBbarg, lakrdlatrlct ail 1 Cuaavrsback, Bxgleha> laad. 1 1 tnnnt oiium: TBSTB: i iioiccvmiTioi: mosmat i i«issto»; neu laiis-, IHB a) 32 ag/g 1 it Tr«at«d •acapbalopatkr patleiti bl 29 ag/g I It Traitad Pt-polsoalig patient* et 33 «g/g I c) Vntnataa aablactB with klgk d) 58 ag/g 1 blood, kigk or leu tootk Pb l«T«la a\| t2 ag/g \| at Qatcoata4 aab^acta vitb low blooa« Mk «t I klgk tooth PI 1«T«1* 1 «) VBtraated ambloctai ulth la* blood. I lo« tootk Pb l«T«li I 1 Chlldraa la Pb raglctrr of iy city. 1 ilUlag* o( toqictry casa aad daatal 1 clinic satlaats. Host trace black. 1 yc. a«m 2.3 yr. 1 Rigfc laeld««c of pyekologlcal 1 nfarrala ail behavior problnc la 1 a), b\|. e\|. CoBTBlcioas la • I tatlaats. » «f •keaphalopathy 1 patleat* MBtally retarded, BOB* 1 atagaomd orqaalc brain ayadroae or 1 Mine* llsoiiler. 1 I itit: inns: cuiisM; nt 1 PoitTtio»: inr ton: ami rcisonte l tiBMios nsdoiis; imi9>iio«: I EiooB: fiRit tuns i nrainci ' ' •». l.I.S. 981 Jovraa.1 of toxieolog} aad VeTlrobBeBtal Health 1: 273-20 Karlavder. H.B. fattea, l.a. 1979 lanal of 1C* urology M^l >21~2k Smta. B. Brockkaos, l. Sentec. S. Schvraau, I.I. 1979 Intenatlonal archive* of Occupational and Enrlroowntal Bealtk «t«5-80 klbert. I.e. Shore. I.E. strehlo. cl SBelp, T.J. Pa»trnack, 3.S. Trledkoff. l.J. COI1B, T. Cialao, J.I. 197* laTlronHBtal Health rnpeetles 7:33-39 HUT ««) 00 ------- 7439-92-1 Ft It! 207.1. IP 327.* C. B* 170 C, TP 1.77 a 8? at 1000 C, 1 •• Bg at 970 C. 10 •• Bg at 11«0 c (comma) 1XSS01 4141 Urine 4U2 BClM 1«1 mine 414 Urine •14S Hrie Birosun BOOT Ink, lit! OB (Oestion IBalTCICM. BRBOB IIS us BS US T •nails OP C1SB «\| S9 b) 77 C\| 51 d\| 70 * 32 7 22 2? 10 II MI 8-40 «g/l •) 11.6-15.4 «g/I b) 4.1-12.6 mg/1 e\| 8.0-9.6 ««/l d) 6.C-9.7 «g/a - 27-38 s«/dr 1.3- 16 uol/2« ir 0.»-1.5 iBol/24 kr lot 9iT«n lot girt lot given Sit I \| Gtllttl XIPOBB1TIOI I BmgEBCE • 1 16 «g/l \| 20 aaaples i Ig«son. T. 1 Direct deteraination and attraction 1 Indrasko, I. j troc«drs agree, j 1971 1 1 ClUical Ckviistcr 1 »«ld«r«, quiq* p«c«oD«l aad putty 1 25(11) :19»8-195J I crk«c» In s»«dt»k airpl«>« factory. I I 1 \| IICOSTBIlt fdlVTtai; COBMB1TITE I \| (TllgiTIOIS; ClBBinU; SVIDEI; IDULTS; \| i BIOOD: nnt; BIOICCOIOIITIOI i t i t 13. 2 a«/l \| •> t«l««. 10 l»aele> 1 jotason, B.B. b\| 10.3 ag/1 \| 11 ?«•«!•«. toa lo««l«« \| Fravost, H.J. c) 9.0 mg/l I e] B«l««, Koetatcr I Tillarf. J.B. 4) 7.8 na/1 \| i) P««»l««, U«c««t«r \| Ca««nn. D.I. SoOMtCiC •MB» \| 1 ROMBfeld. J.B. 1 Californium llli« 4an«in< fro • 1 1976 I fr««T In 10 i4le* or 1* th« high I eEl-«00/1-7C-019. 235 1 d«««rt rcqlo* of lctcr. »j« 1 pp. 1 groapa: 1-16, 17-3, 35 or »or« yr. ( 1 «fl» Ut«. «M ioi-«ttte i* lo« { I l«gle. 90t Uta, JW oon-whito 1 1 j t«ctr. i 1 1 I KlllS; niTXIBB; PUUDIOfl: LB1B; 1 \| EOPOUTIOI ZIPOSHZ: OCCDP1TIOM1 I 1 Bitiits; ctiiroini: toropsnsi i I HOOD: KiDirrs: spiiiu am: mat; i 1 miss: inscizs: ADIPOSE Tissue; i \| IITH: COBPIHTin millTIOfS; •!« 1 1 JMSIT: cmti: sums: imOHOtivs i i i I i 32.75 ag/4y I Iicntio «od«r *liia>t conditions I Balo«lti, B. ( <«nfilt«red alrl doriacj 41-124 ar* I ethrill. l/2« he \| r\| Controls \| Doss In goat, 1 landy, :. I tc prior Pb «rpoore. I fedeen, E. p. 1 1 1991 1 32-78 yr old qont patient \| «e< England Jowwl of 1 1 Bedicine 30»(9V :520-523 \| •« Jt^5IT; IOH1TS: KID1XT DISEaSSS; 1 \| licet; 1IT11; if» \| I 1 oo oo (BUT IkBI) ------- lead 7I3M2-1 ft Itl 207.2, If 327.* C. tt 170 C. TV 1.77 mm B« at 1000 C, 1 as Ho t 970 C, 10 •• B? it 11S» C (COITXItrZDI xisss] 414* «Cl«e BUOSVIB IORZ nimiciL BBTBOD • OBEBI OF C1SK 93 tllGI a) 2-230 «g/l b) 200-4500 »9/2» br c) 10-170 og/1 4) 200-4300 ng/24 hr IE* I •) lot giiaa M lot givaa e) let glvaa d) lot gi»en GEIZlal IirOKBkTIOI •1 loachelated Pb, la 48 vorlwc* •ipoaed at least 1 TT t\| MM-bouad Pb. la ijroop (a) c) ioneti 31 b] 22 SalCl 0.20-0.61 eecj/1 a) lot gl*a b) lot gltea a) lot givea b) lot «!•• Bill lot applicable a) 0.78 « or - 0.01 aeq/1 b) 0.48 * or - 0.01 aeg/1 a\| 0.22 ft* b) 0.40 ppa S11ZUL T1TOBMTIO1 \| 1 faage of Maas Dose, SO 0-500 ag/dar as carbonate. Depressed patients iniTDa: BLOOD f 11311; BZTU5: CBimmitpT; IEIVOVS SISTIS DISUSES a) laasas City, IS, bard-«ater area b} Kaasas City, BO. soft-sat«r ana SigalflcaBtlj higher lerel (f<0.01\| !• bard-cater area. IS aad BO r«si.d«ts satcbed for age (Mat aoaa 37 and 37.7 yr> . m. leaotb of rasldeaoe. aarltal aad eeoaoaie atatas, oecvpatioa, Basber c( chlldt*. uoUaq habit i. hi, t. la bard-«at«r area, significant itexaaa* 1* hivertemslen, VX ataoraalillts, aid bTpomiccsla. ciHU: iissotnii; .DHT.TS: ClltlCTUCniK DISHSSS: BIPTITI13I01; BLOOD SI BOH; ciicna; ciicBTDB; LITBUJB: BismiiB; pHosraoBOns; rotassioi; SCDim; me; BIO1CCTF5U11IIO; ISIKHS vitn a) learalag disabled t) coatrela learalag diaabled aad aoraal 3rd aad 4th grade stadeats la Caaada. cmciuB; BiGitsun; potissms: sconi: ciDaiDS; COBH.T: conn; :«3i: L«III; uiGinsE; tuc; c»onn; mnoB; azsonti; BRU.S; itTi: cniufii; CMIDI BZTEBEICE Balliager, 1.6. Balllager, J. Rlaialhocb. J.9. (ell. J.P. Baain, I. 1990 PBrchopbaraacologr 68: 249-255 Blecaaba«a, B.L. TlelacliBaa, I.I Doan, J. Irhald, J. 1975 laacet 1 (1911 -.1008-1016 Pitil. 1.0. ?»ke, 1. 1977 Scljeace 199 (4313\|.:204-206 oo ------- n-Pkenrlenediuine, (-Mtkoir- (8 CI) 1,3-EeaZelM«iaalne. -netkOII- (9 CI) C 15-05-a C7-110-I2-0 II 138.1 HSSBS • 150 Orine I I Hfosm ions iiiiTticu IRBOD •ram OP C1SSS SUSS 1 on 1 1 sunn moBimo* SeTle. local aaa STatenic effects relating to kale 4ye fornulation. iigccdint t««ts. aad «rp«ri«nc«« in MI »nl iiliali. KBITS: niBiWius: Ropiisgs; asm: I T2TIO IIHTSISi II TITO 1I11TSIS; t'TIIt; OTIS; CUdlOGZI; COSHBTICS; siimc inters; BIHTH gizmos; •RlBOtlSI; 8R1B01ITBS U7IREICE Banolli. r.I. erces. s. Mibach. H.I. 1«7« Journal of ZBTiraaiental Pathology and Toxicology 1:589-530 l-lolgaiid. I,f-di«tkrl- (I CI) (•nuiid. l.f-U«t1iTl-3-utkrl- (« CI) 13»-62-3 C12-B1T-I-O II 191.2C. Bf <2S C, BP 160 C at 19 u I«. Ill C at 1.0 mm aq 1ISSOI • 151 Blood znosots BOUTS DKWl nil men HBTBOD 8C/HS BOBBIE or cists i «»»«s lot giT«n 111 I 0.3 ag/100 •! CBBIML IIFOBBITIOI 8 kr after application of 10.* 9 of DIR (133 KJ/tl) in a coiMCcial i>a«ct repellent to about 75* of skin aicfaee. 30 IT oil, lit 78 kcj OltTBD ST1TM: 100ITS; B1OOO; BUWK; nsnciais; n TITSO IULTSIS nrzKwct la. 1. Pearaom, B.l. Skekoski. 0.1. Soto, B.J. Stevart* B.l>. 1979 Joenul of High Sesolation CkTOMtoacapky and Ckronatograpay Coennn icatioos 2:«8-5«2 VO O ------- a-iTi» ca en !>«••. 1,3-4i»«tafl- (9 CI) HI-38-3 Ct-110 ii we.it, n -47.4 c, TP n •• Bg »t 21.3 c tissn 4152 Blood 4153 Blood IIS4 Hoot MSIM BOOH akalitloa lualatin iHimcii BIT BOB OC ec ec io»n' i UKI i Btii i eiiEBit IITOBRUIO* i umncz or cisis ill I iii i III I I a) lot gin* 1 a) 8.2 » or - 0.8 1 a) Boiaay «-•-. «ok 1. air 1T1 4.1 I SarolalM. E. I b) Bet giwi 1 uol/1 1 »oVl 1 BtlkUaU., T. I c) Bat gim 1 b) 9.9 » or - 1.6 1 t) Roiday p.., Mok 1, air !•»«! 4.1 I linaoila, R. 1 d) lot gira 1 aaol/1 I uoVl I 17* ) o) lot Jim I et 1D.6 * or - 1.5 1 c\| Friday a. a., iwfc 1. alx !»! ,2 I Xatcraatlonal lr£kir» I f) Bat gimi 1 aaol/1 1 •»1/1 \| of Occip»tioul ud I g) tot gira 1 d) 19.9 or - 1.C 1 d) Friday p.., *k 1. coaontratioa \| nvtroiMital Beam \| I a oo VI 1 ii ait Ural 8.2 uol/1 1 44:201-211 1 1 •) 8.7 » or - 2.1 1 «) Boaday a. a., cook 2, air lOTtla 1 \| I »ol/l 1 llietiatlia. it 4i 1 «nl/l 1 \| t tt ».4 or - 3.* 1 f) aoiday p. a., wot 1, ale !•»«!» \| \| 1 uol/1 I (lactutlig at 4.1 uol/1 \| \| 1 A M.I * or - 3.2 14) loawiaai p. a., «o«k 2, air lerol I t 1 1 I I \| 1 at 1811 ca, MI rt 70 k. \| BaTiroiMStal E«altt 111 1 43:154-150 1 i i cccoriTiOMt iMitis; «EBBIIT; i 1 1 1 ItUlTS; HOOD; CatCIlOCI* 1 1 1 1 1 III 1 » 1 a) Bot gl»«i 1 a) 21. « * « - C.3 1 a) Trutmt Say t, ooastaat orponn 1 aanlalna, C. 1 b) Bot »1»« 1 «aol/l I lti«l (3.1 niol/U ( tllliUaU. T. 1 c\| Bot gifn I b) M.7 * or - 27.S 1 t) 1roatnt day f. ooastaat exponro j Soppalaiooo, t.B. 1 at lot gim 1 aaol/1 I !«•! (B.2 «al/lt 1 liuolla. R. 1 •) lot gim 1 e) 29.5 * or - 4.2 1 c) Tnatcat day 6, following 2 1 HBO 1 f) lot gim 1 nol/1 \| mitmtmt day, coistaat »ranr« 1 Xitanttloul ltcU»«i 1 1 dl S1.0 OP - 2.4 llml (3.7 uol/U \| of Oceapatloul ud I 1 «oVl 1 d> IroatMit day 1, fariabl* oxpomn 1 iBTironaamtal g«altk • \| 1 •} 117.3 * or - 23.8 \| 1««1 (tiic-Mlgkcod avorag, 3.8 1 49:105-121 I 1 uol/1 1 aiil/ll \| I 1 t) 48.1 » or - 18.2 t«) Troatnat day 5, variable oxconro I I 1 uol/1 1 !•»! (tloo-Migktod avoraq, 7.7 I t 1 laiol/1) \| I 1 If) IcoatMBt day 6. follmiig 2 1 ) t 1 ic«tx«atM«t days, variant* oxponcc 1 1 1 I ICTOI ItiM-Migktod anragt. 3.8 I 1 1 laaoVl) t 11 1 1 1 1 (.tilth? wlntMis. MU ao« 23.* * 1 1 1 let - 1.4 aid 24.T * or - S.I Tr 1 1 1 * 1 1 1 1 Iipairoaat of body baluc, raactioa \| 1 1 1 tlati, aamal coocdtMtioi, and 1 I 1 Ickaogos ID EM. I III 1 1 I irnuit; nous; noon; CO»UHITI i 1 1 1 ItlLUKIOlSj BBnniS; IBBUtTIOir 1 1 1 1 1 ------- a-lTleae «8 CIt tBBSeae. 1,3-dinethyl- (9 CI) 108-38-3 CI-110 B« 108.16. RF -»7.» C. TP 10 » Kg at 28.3 C (COIfllOBD) 1ISSOE «15S Breath ZXPOSmS BODTE 1BUTTICU. BSTBOD 6C-BS mates or CISES 54 (387 sanples) B»«I •Ot given 1 Bill 0. 32 ng/1 Se one trie GEBZBal IBFOBRaTIOB leasarcd at 25 C aid 760 as Bg 15.81 occurrence lower and vppar one-sieBa liaits 0.05 a«l 2.32 agyl Htalthy, 1895 yr old, nonsaoklag. at tan blacks ud caacasiana. Chicago, n. Bigidly controlled •ipcrlMital canditiona. IIHTH; IICOBOLS; I III 101 S; 1DOLTS; CKCBIMTrD BIDKOCtlBOIS; TOlltni C1GIIIC COIPCVIDS: BZUTB HlIl'BS: iiBit»iof; mrr»Bonss: HJTIEOLITBSJ fCPOUTIOI (IKS01T; OSB»I JB11S IBFKSKBCB KrotoszTBski, B.K. Brnneso, e. R. C'leill, B.J. W79 Journal of Inalytical Toiicology 3:225-23* lagnasioi 1»39-»5-« B« l«l 2.305, BP 651 C. B? 1100 C, TP 1 •• Hg at 621 C. 10 u Hg at 70 tissnx 1S6 lorts 1S7 Elool EXPOSOBS BOm tliLTTIOl BETHOD U HOBBIS OF C1SES 2 BIISI 110-860 ug/g (vet it) a) lot 9iT«n b) Rot git ft c) lot giT«n d) lot giTeo ej lot giCB f) lot given BEaB \| S1IIBIL IBTOSUTIOB \| 1 •90 » or - 530 og/g I tales (»r chives of Invironaental Health 3S(1):3«-« CockbnrB, F. Bel ton, U.S. P«rris, B.J. eiles, R.B. Erovn, J.I. Tamer, T.I. MlkiBson. E.B. Forfar, J.O. Barrie, W.J.B. BcKay, e.s. Pocock, S.J. 1980 British Radical Journal 281 (62 32): 11-1* VO NJ (BEIT VISE) ------- 7«3-SS-« ' e;i c. » 1100 c, TT t •• B» at «2i c, 10 » t« «t T«O HSSB1 aiSi Blood, sena Bra Is • ISO Bail xrosniB soon 1UIYTICU HCTSOO US u IIS •mm or Casts 2«0 20 a) 31 b) 22 llKI lot gi»e« lot «lrei a) 79-»OC aq/g (eet «tj b) 100- »«0 »g/g (wet it) c) W-329 wj/g (wt t> d) 57-2(0 ag/J (vet >t) a) lot give! b) lot glrea mi i stum IBKHBIIIOM I 2.01 » or - 0.01 I a) (ansaa City. IS. hard-vater area eoyi j ») Kansas city. BO. aoft-»at«r area 1.41 » or - 0.01 I Slqalfleastli Ufaec leral \|«<0.01) net/l \| i« aard-vatei area. t j 13 an «0 rttfdeats aa toted {or age \| flea. a«e 31 and 37.7 ?rl , ex. I lasotk »f resideaoe. aarital aid j eeononle itatu, oceopatioe, naaber I cf children, saoUoq iabltm, it. t. 1 1 la haro-mter area, Blanificaat I liereaae i> hfperteBSlon. ICC I ataorealltles, a ad hrperacicasia. 1 1 inns: itssOTBi: »ntsi \| CISIIOTIScatUt OISK1SSS-. 1 E1PMTH3IOI: BIOOD SJBOB; 1 CCRPIHTI^I nuonms: CIDBIHB; 1 CIICIHR; cRtcRioi: iirRim; I BiGixsiBS; tftosrcosoos: pOTissira; 1 sctmni; n«C; BioiccoiiouTiai; 1 HIIKIIS urn i a\| 210 • or - 100 t a) Bales, ceiebraa, t svbleets 99/9 (••* «) 1 " T«aa«s, oerebru. 2 rabjecta b) 270 » or - 20 \| O Bales, cerebellea. & BBtjects ng/a (>et »t) I o) Feiales, eerebellu, a aabjacts ct 170 » or - 8S «g/q 1 (vat t) \| tioa a <\|roap of Cl antopciei. d) 170 or - 90 H9/9 \| forensic eedlcal aiaalaatloaa, Japan. (•et «t\| 1 (ales, aaan aq« ao.« jr. feaales. j aean a<]« 37. * jr. 1 I TI1CZ nZHniS; IBTOPSIES: JIP1I; 1 HHRIIOB; iBsraic: CIBBUJB: COBU.T: I cticmii; cop»!B: ZBOI: BCBCOBI; \| 1I9IUR; RIOBISIDB; RIIB1BZSI; 1 lOCIDIOB: HBTI10IT; SCITOIOH; 1 ittzilll; TI1III01; TIUBIOH; {IK: I ectt: asonzBt: IIT^B; KIDBI^S; t CIJIBS05; CIBEBZUOR; HIIBT; ROSCIES: 1 iHcnu: stii»i miss; xcsii; I iniis; coKiiBinrB STILOITIORS: sn; \| IOBIBSIC HniCIRE i 1 a) 35 ppa \| a) I«anla9 disabled b) 37 ppa 1 I) Controls 1 1 I«ar«l»BBB. J. rnold, J. 97S aacet (HU(l100«-10U Taka«a, B. Seiaki-TasuBOto, a. laaBo, E. Tarai. R. 1980 IrehlTes of Eailronacatal Health 35(1);3-aa Ilbl, B.C. Parkes, B. 1977 Scieace 198[»313) :20»-206 (HIT FUSE) ------- 1439-9S-4 »9 Itl 24.30S, ft 6S1 C, 1? 1100 C. Tf 1 M. Iq at 621 C. 10 •• tg at 740 IXSSBt 4161 Batr 1162 (•art 416) Bairt 4164 IUMT EMOSBBC ion _«__________ 111LITICU. BXTBOP U US a BOB an or CISBS at 4 W 2 ) 14 I 7 £ 2 1 MBS a) 87-420 (9/9 (»t »t) b) 110-320 «9/9 (a«t at) ) 94-246 09/9 \| 197-251 S9/9 at »t 53-250 «9/9 (Mt vt) 57-130 49/9 (aet at) (am 1MB \| CIBIU1 IBFOBB1TIOB 1 1 1 I prs-aaalysis treatsests ara I tabulated, tha faasibilitr of a \| holistic. BO-vash policy for hair ( (Hirsts Is oatliMd «aJ sspported. i ftvisB; TBtci Ennui; am: I 18S1BUI1; BZISBBIBSBT BITBODS: 1 itTalSt PtoiHIS; COWIBITTO 1 tmoiTiois; aLBRiBim: iBrnowr; 1 nsmc: BMIBB; BBOBIBE; owios; \| C11CIIB: CB1CSIBS: CBKOBIOB; COBALT; 1 ccrtn: siiitvit; ennuitia: «jio,- 1 lOBMI; MOI; Ll«n»IOSj iBIt; \| BaSBISIOB; B1BSEBBSI; BBICOBT; 1 tcimravi: HOCK: ttosttovas; \| IOIMSTtl ------- MgMill 7«3f-S-« «9 Itl 24.305. a 651 C, IP 1100 C, n 1 u 14 It 62t C, 10 u BiJ at 740 1IS3H »1«5 lllOX • U« l«»9 »1«7 luclo nosnc «cim tlURXCU. BTTIOO U U 11 nnsi or cisis 10 3 a) 2 t) 2 a) * b) » tllGX 1 37-750 ag/j \|«t «t\| 1 M-200 »g/« (««t vt\| •) 79-150 «g/g (»ot »t> I) 86-110 ag/g (««t >t) \| 130-180 «g/g <»t «t\| b) 82-500 o-)/g \|Mt »t\| 1111 ) 20 or - 210 g/g (net «tl ) UO » or - 83 «g/g •«t »t) - a) 110 * or - SO oq/9 (wt «t) b) 98 * or - 17 ag/g (»ot «) a) WO * 9t - 11 n«/i («»t lit) b) 230 « or - 1(0 ng/g (»«t »t) cciistL MToismoi i nnmci i i i a) lain I Tokaw. 1. t) T«m«l«B \| sazakl-lanuto. g. 1 lino, I. Jtoa » qrop of 61 aatopii, I Tcrai, 1. female itdlcal •xailoatioM, Japan. I 1980 Balw, Htt aq« 0.« it. T«ul«s, I lieaif«a of a«a» aq« 37. « rt. I miconnatal B«alth 1 35(1lt3«-M t»cf mints: inoMiis: j»i«; i lUBim: ttsmc; cuuoi; COBUT: i cnonai: ccmt; noi: incint; i iiexiiii iisiisioH; UIG»I$E: i HIIOIH; IHIBOJl; SCIIBIDSJ ) si»ms; Tiunoa: mioin; znc: i 6C1B; noun; inn; noiirs; i citintn; ctitBium; m»: anscus; i (IKItlS; Stini; 1D1SS; Mm; \| erru.it coiFit»in CTIIDITIOKS: sii; I fCSIISIC »tICI» I 1 1 •) nalas ( Taka«t, R. t) »«aal«« \| SainU-UMKrto. a. 1 laao> I. froi a IIOIF of (1 »topil«i. \| Tr«l, I. loc«asic Hdlcal uaalutioit, Japan. I 1980 •aim, aora ago »0.6 rr. Tonlos, I &cchl«> of !«»• ago 37. < TT. 1 EalroMoatal Baaltk 1 3i(1)-.3-»» 11 1C! ILlBtllS: lOTOKItS: IU»; \| iiomii: itsmc: CIDBIDB: COBU.T-, i cBioaii": ccmi; itoi: incnti: i iicuja: neiism: UKIIISI; i mtiBitis: innon; SCIIBIBB; i sntnvi; miiioi: wnoiti: zi«c; i son-, Btogiit: Lint; ngns: i CIBI3IH1: cnsBxiiOB; nan; aosciis; i iiiciEis: siim: inesi aoiri: i RtTUS; COHTIUTin MliO»IIO»S; S!X; 1 retnsic itBicin i a) lal«s \| Tnka«a, 1. t) Toialoc \| sanki-Tancoto, S. 1 aaaao. (. ftop a gronp of £1 aatopaios, I Torai, I. forma le Milea! oxaaliatiou, Japan. I 180 Stiff, fffa ago »0.6 rr. loialos. I lreki«s of a«ai ago 37. » re. I nrtcomeiktal Health 1 3i(l):36-a» i»ce niMRS; mopsiES: Jirii; i UOniDl; I.B3J1IC; CaOSmS; COBILT; \| CHOHItri; COPPIR; itOR; BI1CDBI: \| ntwa; aisusioa: uneivtSE; i BVBIDrra; 1RI10BT; SCI (BIOS; f snifin: TiTuioa: TIBIOIO; zi«c; i ecu: notin; iifn; UIMHS: i CIBIBB11; CtBtBEUVR; HHBI; SDSC1IS; I lucitis: siuEi; LUISS: icsti; i BITIIS: COHIUTIVX zfunmovs; six; i rcinsic fiiciciBE i i Ui (HIT PIG!) ------- Bagnesiva 7«3»-9S-a Its 24.305, BP 651 C. BP 1100 C, TO 1 aa Bg at £21 C, 10 aa flg at 740 (CORIKIEV) HSSflB 4168 Pane rets «1«9 Spleen 4170 Teetb BIPOSBBE gOUt AIALTTICAl HBTHOD U U US BOHBEB or cisis «> * » 2 a) 5 b) 3 » 51 b) 10 ) 10 ) 26 ) 11 O 51 I 10 > «8 BAIGS \| Bill \| GEIItll IIVOBIATIOI 1 1 1 1 1 1 a) 210350 ag/g (vet »t) \| a) 230 or - 70 og/g \| a) Biles b) 260-320 og/g (vet vt) I (vet t) I 1) resales 1 b) 290 or - «2 ag/g I 1 (vet vt) \| fro a a group of 61 autopsies, I j ferensic aedical examinations, Japan I ( tales, eeag age 00.6 yr. resales, 1 I Han age 37. • vr. 1 1 I i »>CE niRzns: ADTOPSIZS; JAPAI; i i AioRiiDR: itsmc; caomna; COBALT; I \| CHOBIU5; CCCPEB; IBOI; REBC0BY; 1 i iiDim: msiisiDB: RAIGAIZSB; I i BOBiDios; AniROii; SCIIDIOS; 1 i siLMWR: TIT AII DS; VAIABIOR; titic : I \| GOLD; BBOBI«I; IIT1B; KID1IIS; 1 \| CIBBBBUB; CIBtBniOR: BE»BT; B03C1IS 1 i nicBEis: SPICT«: LORGS; OITI: 1 1 BITUS; COIPU1TITS ET1LV1TIOIS; SEX; 1 1 FCB'ISIC BIBICUE 1 1 1 1 a) 120-560 ag/g (vet vt) I a) 230 » or - 190 I a) Bales b) 65-580 ng/g (not vt) I ag/g (vet vt) I t) males ( b) 320 « or - 260 I 1 ag/g (vet vt) I ftoa a group of 61 autopsies, 1 \| forensic sedical exaainations, Japan. 1 I Rales, aeaa ag« «0.t rr. rcaales, 1 \| i«an age 37.4 vr. 1 1 1 \| TB1CI fllRIHS; aMOPSIES; J»P»»; I \| IIOBH11; 15SBBIC: CIDSIUB; COBUT: 1 1 CGICRIUR; CCPPEB; 1B01; BEBC08T: 1 \| IRBIHB: RiGirsiDi: aiienzsi; 1 1 IDBIDIM: HIIHOII; SCHDIBS: 1 1 SII!»I1B; TII11IOB; TalASIDR; ZIIC; 1 1 GCID: BBOBII!: tlTES; KIBHHIS: 1 1 CIBIB55S; CIBBBItDBt HE1BT; ROSCLIS; I \| S1ICBE1S: SPIZER; IDIGS; JOBT1; 1 \| a!T»LS; COBPaUTiri ETH01TICBS; S!X; 1 i res-isic gzticzit i i ) 2-5 mg/q \| a) lot giren 1 a) Iiaael. rural area vita < 13 ag ) 2-3.7 sg/g I b) lot gireo I Hg/g soil ) 2.3-3.5 ag/9 \| c) lot girea \| t) Eaavel, rural area vith 13-19 ng 1 2.2-3.9 g/g I i} lot given I ag/g soil 1 6.5-8.1 ag/g I e) 7.4 » or - 0.3 1 e) Znaael, coral area vith > 19 ag I 6.8-9.1 ag/g I ag/g I Ig/g soil 1 7.2-11.1 ng/g \| f) 8.8 * or - 0.2 1 d) Enaael. arban area 5.8-9.1 vg/g I sg/g I e) Dentine, as in (a) 1 g) 9.0 » or - 0.3 I f) Dentine, as in (b) 1 ag/g \ g) Dentine, as la (c) 1 h) 7. 1 » or - 0.2 \| b) Dentine, as in (it 1 aq/g 1 Ktiiated fres graph (a-c) I \| Iqt dependent data also presented 1 1 1 I fesldeats in Finland 1 1 I i Tinuo: «st : sai; TEETH; COIPIMTITZ I i !t«m-io»s: ueizsiin; zuc; SOBIL I i mils: ntsii asiis: RETUS I i (IZXI PIG I) BIRBIICK Takava, H. Sn-nki-TaEanoto, R. Aaano, K. Terai, R. 1980 Archives of Envlronaental Health 35(1):36-aa Takava, H. Sa-aki-Tasnaoto, 9. laano, K. Terai, 8. 1980 Archives of Environmental Health 35(1):36-aa lappalainen, B. Knaottila, R. Salsinen, B. 1981 Archives of Oral BlologT 26:1-6 ------- Btgouiai J«W-»S-« •» Itl 24.30!. ST &S1 C. » 1100 e, f» 1 n H? «t «21 C, 1« •• Bg »t HO (COITIIIED) TISSUE \| :rj. EIW3UIB WUTE Ingestion RCIBOD US OF CISIS 10 JM6S •at jives •Ell 9s, • or - 21 ng/aaT 6Eimi IITOHIUlai IOM after aaanpplcaaatad intake of 2(4 aq/l«T. Data, Croc VT 1-07 •ipcrlnaatal periods. nnlwrsltj students and eaploTevs, a nare ml a teachac. InlUparoua, nga 19-29 jr. Rio^MBlti calanee cllqhtlv negative, nfleetliq intae^itte Intake (60t of •JI). itmssti: OBHE: HOI; CIICIDR: »i6iesiin: siriuiS: PiospBOBOS; DIIK; I1IIEE11 BITlFailSS: PBISrilCT tznitvcx - - lsh«, J.B. Scbotiald, y.l. 6ran, R.I. Inerlcaa Journal of Clinical Intritlon II Itl St.«3BO, If 12M C. BP 2095 C, TP 1 aa Hg at 1292 C. 14 a« Ig at 1510 C US SHI «1T2 lorta 113 BlooJ «1T« Elood EIPOSBB! 10DTE 1 1 ' HJHTICIL \| BffTBOD \| „ IIS us •niBSR 1 or cisss 2 60 a) 18 bj 20 O 25 dl «J I1ISE 0.38-B. 86 ag/9 <et «t) 3.85-15.1 «4/l a) Vot given bj lot given c) Fat given d) tat glvca (•EXT mi 0.62 or - 0.3« og/g fv«t «t) 9.93 + or - 2.25 «q/l a) 0.96 og/100 al b) 0. «5 ag/100 ll -) > 1 U9/100 al 1) > 1 og/100 al neilaaa PJGI) GEIFB1L IITOIUTIOI Biles Icon a grovp of 61 a«topsie«r farensle nedlcal eianlnatlcns. Japan. I ales, naan age H0.6 re. f«a«l«s. •can aaa 37.4 Tr. UICT amiTS: trropsiES; JIPII; iioima: ntsnic; ciDani: COEE.TI CtlORIOI; CCEPTtS; I BOS; BIBCOCI; IltTUB; IMilESIDR; tHBlIZSE; losioinj: iniion; scuuias: SflHin; TITHIOII: TiaJDinn; n»c: GCtC; B»R»l; LITEI; tIBlIIS; CHtBBHI: CZIEBEUDI: HZUT; ID5C1IS: piicn»is: siirs«; LOSS; loni; BITU.3; COIT1MTITE ET1101TIOTS ; S!I; fCHISIC BSIICIM lo eorrelatien bef »n concentration and age, aex, or anktnq. B»altiT» nonfasting 15-83 ji olds. E100S; BEHSUJIBIII SIT BODS; iiieinsi; amis a) tors liiiaq < 1 kn (con saelter tl Gltls Uyl.q < 1 ka fro* suiter c] Groan children 4) taral children Htlaatsd (ten qrapk. School-age chlldcen llilnq >aar Pb stelt«c In Belgian. Controls tro« raral and artan aceas. niGimst; ciDiion; IBSEHIC; HSEIIC CE1IKIC COBICUSDS; CBILOBEI; IlIISTtTlL linOSPSJSIS; SHIITEBS: "ITALS; BlOCt: DBISS; SE1GI3B; PCPOtlTIOB IIPOSOBE; BOBJl IBE1S; CBEII HESS imaEscE Tnkava, S. SHnkl-lanvnoto, B. laaao, K. Terai, R. 1980 Irchlves of Environmental Realtb 35(1] :3S-m Pleban, P.I. Cearsoa, K. B. 19T9 Clinical ChenlstCT >s 15-191* Sachet, J.p. Boels. 3. La over ra, I. Eraau. f. ClaeTS-Ibdrean, f. lafantalne, 1. Terdnrn. S. 1990 Ecvlronaental Eeseacch 22195-106 ------- faaaa 7«39-9«-5 •I Itl SV.9380. IF 12»» C. BP 2095 C. TP 1 aa B« at 122 C. 10 •• B« at 1510 C (COItmiO) Tissn 1TS Blood. sens »17S Brala •177 Brill • 17» Iteatk »17» ' •tic siposwj sotn BkalatloD laitmciL BCHOD us >* us mi us i nun or USES 20 3 31 22 III6S 0.9«-2.92 19/1 •\| 0.11-1. a 09/9 (Mt rt) b) 0.42-1.1 ag/j (net t C\| 0.0«-0.91 aj/9 (nt ¥t) d\| lot gir«« - a) lot fflru b) lot »iTe» c) tot girt d) lot givei •> lot 9ir«a f) lot 9l«n at given lot giro lot glTei BEII i GEIEEU iiroBBMioi i 1.82 * or - 0.6» 07/1 i 1C correlatloa betveea coDccctratlon 1 nt t$€, MX, or nokiB«. 1 Bcalthr. •oafutiog 15-83 jl o!4>. \| StCOB SEI1M; HMSTOlnlWT IRBO9S; I tncmsi; RETUS i •I 0. S» » or - 0.27 \| •) fil«, ccnbni, 9 a«bj«cts lutloiia, Japan. ng/g (nt «t) I Bilas, ••> 19* »o.« yr. r«ul«m, j Maa aq« 37. a jr. 1 met ntims: IOTOPSIES; juu; I HORinH: misnic: cinnirsi COBILT: 1 cfFOBitm: corrsB: isoi: HIKOIT: I iioKrv; iieirsiVR: micirtsE; 1 «eBiniu5: iniBoir; scMoitn: I stiEiiae: iitHim: miDiua.- n»c: 1 COLD: Bioiiii: LITEBJ KID»ITS: 1 CIBEBSfR: CEIE8E1£09: HBlSt; BOSCIES; t EHCItlS; SPUEI: LOKS; 10BTI; I imiS; CO»P»B1TIT1 ETtLOlTIOfS: SET; I fClEfSIC 1HICI1E I 1 a) 2S.S * or - 0.9 1 a) Slabni patlidas. 11 saapl«s, aaoVg 1 cceffieloit af varlatioB (CT) 11. 9T b) 2». a » or - 3.3 I r) Can late aocleas, 13 saaples, Ct aaoV9 1 •'M* e) 3«.a 4 or - 1.6 t c) PmtaMi, 12 saaples, CT 1«.5t uol/g 1 1) Sibctaitla aiqra, 6 saipl«s, CT a> 22.« « or - 2.0 1 21.71 aiol/9 1 «! Cerebral cortex. 15 saaples, CT e) 15.8 • or - 1.8 t ««,5* »oV9 1 d Rlppoeaipai, 9 aaaples. CT 35. OT f> 32.8 » or - 3.8 1 aiol/9 1 Utopsj mples »ry «t 1 SB 1 CIBEIBU. COEIEX: niSVIEBEn BKTHO5S; I ciicnn: eoprzi; noi; iiisimsi: 1 EHIl: IBTOPSIK 3.0 a9 1 C 1 saapled at cat* of 1 I/a In. 2-10 1 ala after baraio? * are veldlag rots. 1 OltrecsltT pkfsics "bop. Florid* 1 F1CEI91; acnTS: 91I1TI: CIICIW; 1 CHtosMS: cnomi: copm: IBOI; 1 I»D: »«u»SE; ncxEi: POTISSWB; l Sutra: Tninvi: TIIIDIBB; znc; IIB 1 FUinioi: rsBis: IIDISTIIU 1 IT90SPBSBK: TlaCE EISBIITS 1 ) 0.83 ppa 1 a) learal9 dl»afcl«d 1 0.58 ppa 1 b) Coitcel 1 1 Ktraini) disable* ad aorial 3rd aad 1 «tk 9cade atadeats 1 Canada. 1 1 cucin; Baensim; portssioBs 1 scnun: oomi: coia»; copcEi; 1 TtOI; Itat: RtKinSSl MIC; 1 cttoMQ: Limvn BncniT; BCTILS; l mil ntimi; CH»D» RFCEEICE Pletai. P.I. pearsoi. K.B. 1»7» Cllaleal Chealstrr 25(11J s«»5-1918 Tnkata, B. Saxakl-Tanaoto, K. laa«o, E. Terai. a. 1980 trcairee of EavlronMatal Health 35 (tt : 3«-«« Goldberg. «.J. illea, I. 1991 ClUleal Cbealstrr 27(a):S«2-56« " ftksals»0n. K.E. )esaedeleer. G.G. Johansson, I.B. BlK!hest«r, J. ». 197« lanals of Ocenpatlonal Rfgleae 19:225-23* Plbl, B.o. Parkas, B. 1»T! Scleace 198(«313) :20-206 VO 00 inn ------- 1«39-9«-S II It! 5.30. BP 12** C, BP 2095 c. IP 1 aa at 1292 C. 10 •• 84 at 1510 c (COITXmiD] nssci 410 Bair »181 Itir 1« lair iKsnn Borex iiunxcit BKHOD U U IOHBBB OF CUBS al 38 b) 2* O 37 1) 2* •1 16 a w ) 23 b) 19 o «2 a> 1 •} 26 O 0 11KB •) lot 4iT«a b) lot gin c) lot qirtB 4) lot 4ima •) lot giTe» f) lot giTeo a) 0.030-2.663 «4/g b) 0.156-3.72* «g/4 C) 0.030-3.72* 14/4 a) 0.123-.901 vg/g •) 0.038- 1«. 330 B4/9 f) 0.018-16.330 og/q mi \| GEIBBIL IimiHIOI 1 1 \| lel««. 2* represcatatlf* 1 Fce-aaalyflta treatveata ara I tabilatei. Tk* f«sibililr of a I aollatic, m«-«aak poltcT foe h«.lr I iiilT«i« la mtllMfl aai «ipport«d. 1 cirtn; -ttKt VLtmtn-. ins; \| ITSTJU.Il: BIlSmiBlR BCTBOnS; I anus; pBOTins; COIPIUTITZ 1 ninitio»s: UBnm: MTIMII: I itsnic; Bi«wi; Bionre: CIOTIOB; \| C11C1VBJ CnOtllZ; CB1OBIBB! COB11T; 1 ccmi: siiLTUB; g/4 \| c) 111 eoitccl* 1) 0.279 og/4 \| 1) Blla loltipla Kl«eoi« patients •) 0. 6< ng/q \| •] r«Ml« »ltlpl« Klcroslc patlaata () 0.403 14/4 t f) 111 Mltlfl* Klacoti* patlaita italiaas \| Sa«pl«« froa 7 scalp sites in «ack 1 cabjKt. I cum: iDoiTS: CBITHI nitons I STSIEB nsiisBt mi; tionni: 1 ««cmi-. ciicniB: cnoilii; cop>n: I envt IOPIIB: m«s»itsi; anus; I snnm; suns; SODIBII; SHFTH; \| 1111B11V, T11C i BRBZfCX Ckittlcbocoagh, G. 1980 Scl«aca of the Total EvTiroamBt «:53-T5 eibcoB. E.s. Omolta. B.S. 19BO Ivtritloa Baports IntAnatlocal 21 (3) : 31-39 Bjan, D.I, Rolzbacher, J. Stnart, o.c. 1978 Cllalcal Cheatstrr 2* (1H -.1996-2000 (HIT MCI) \D ------- Raigaoese 7.21-«-5 Be »tf 5.3«0, SP 12«« C. BP 2095 C. TP 1 » Hg at 1292 C, ID » Hg it 1510 C (C01TUOED) TISSVE 1»3 Heart • 1« KUaer • 185 KUaeT EXFOSORZ eon am men BRBOD U I •1 roam OF CaSSS a) * b) 2 M ^ b\| 2 1 8 1 » c\| 10 SJ1CB a) 0. 26-0.11 ng/g (vet t) b) 0.52-1.4 og/g (vet «t •) 0.21-1.0 og/g [»«t vt) b) 0.43-0.63 «g/g (vet •t) ) 0.050-0.85 eg/g ) 0.0050-3.62 »g/g > 0.013-1. 7» ag/ij fet rt 111) \| GEKRU IIFOSR1TIOK j 1 t) 0.33 » or - 0.06 \| at Sales aq/g (vet vt) 4 t} Feaales b) 0.96 » or - 0.62 \| ag/g (vet vt). \| Fro i group of 41 autopsies. 1 forensic vedlcal examinations, Japan 1 ealts, MID age »0.6 rr. Feiales, 1 a«aB ag« 37.4 TI. 1 1 T»cr BtBBBBIS; 1UTOPSII5; jiPltr; I I1DBIIB9; »»S!«IC; CIBSIDB; COBU.T: I C BROS 111 t CCPP1B: 1801; IEKUBT; \| I1DIHH; (IlGICtSIOS; MIGtffESE: \| SIBIDIHJ; UTIBOII; SCHDIOfl; \| SILIlin; TIIUIOK; TIHDIOB; ZI«C: \| COLD; BBOBIHE; III ft: KIDIZTS; \| CIEIESHJ; C18EBEILOB; HEIST; BDSCLES; 1 farcins; SPIEBB: LOBCS; lOBTi: \| IT11S: CORPtBlTITS STUItaTIOISj SIX; I TCBIISIC REtKHE 1 a) 0.76 or - 0.28 \| a) Bales «9/ males b) 0.73 « or - 0.1* ( «4/9 («et vt) \| Itoi a qroop of 61 autopsies. \| foc«slc eedieal axa»lnatlo»i, Japan. j Bales, Bean age «0.« Tt. Females, I Han aqe 37.4 fr. 1 1 1B1CI tXIRins: aOTOPStiS; JaP»; I iiOBinm; aEsnic: ciDsioa: COEUT: i ce«o«iatf; catttti teats itttcasr: I IIDIH1; gaSIISIOl: ItlGlHZSI; I toinn: IITIBOII; SCIIDITIB; I SILIIinS; TIT1IIOI; TalUItfg; 3IBCJ 1 GCID; RIORIII; IHEB; !tID»BIS: 1 CIBIBSnif; CZ1EBEUOI; B31II; RDSCLES: 1 PlfCIElS; SPIEZ1: LTJPGS; IOBTI; I RtTaLS; CORPallTITE ETUKaTIClS; SET; \| ICKISIC HZDICIIE a} 0.073 19/9 1 <) Coitrola b) 0.073 a?/g 1 I) vorkec group I O 0. 076 ug/g \| c) Vorkec gcoap II «et vt 1 elians I Ceceasei ret luerr a«d shelter 1 tetkets, aget S5-7S rr. exposed to 1 tearr tetals 1-3 tecaies. Ilae 1 tctiem retlraaeit aM death 0-1.5 rr 1 It group I aai 2-19 ji, group II. 1 Coatrols, ages «3-72 re, vbo lited SO 1 ka (ros tie factory. Svedei. 1 1 SHIM: CafiaTBRS; KIMITS; 1131: 1 tEiGs: coRpitHira EnLoiiiois: 1 IIIIISTCIat ITGIEIEi 1JISOEIHBIT I BIT BODS; iniBOIT: atSElIC: CISRIOB; 1 CfSni; CBICBtVR; COB1LT; COPPJB: 1 cent: isoi; iuwtMin: isic; 1 eiiSMiss: ancoiT; HOITBDEIOR: 1 IECSPBOSOS; BTOIDHJ1: SCHDIOT: I £itEnn: snr-s; TI»: TOIGSTEI; 1 ZIIC; 9!11TB HIEIEDS: IIDDSTBIll t PtinS; SREimS; TEllVSXOH 1 EER1BDCI Tukan, 15. Snuki-Iasoaoto, B. Aaano^ K. Terai, R. mo Irchires of EnvicoBaeatal Health 35(1):36-«» Takava, R. Samkl-Iasuioto, R. Itano, K. Terai, B. I960 Irchires of EnTironaeDtal Health 35(1); 36-* iraae, 0. Vordbecg, 6. vester. P.O. 1980 Science of the Total EBTltOBient 16:13-35 ilKT Past) N5 O O ------- BiagaMM 7«9-«-5 Si Itl 5«.«3M, 1«« C, Bi 2095 C, W 1 » If at 1292 C, 10 u Ig at 1510 C (COITIIOEM 1ISS01 •us Kidney • UT lifer »188 Li tec • «» liiar EIPOSUIE BOTH novation IngestiOB IBUTTXCU IHBOD n 11 IDBBEB a; cists at 11 b) 3 a) « b) 9 O 10 BMSE a) lot given b) 0.96-2.3 uq/9 («et >t> a) 0.017-2.18 19/9 b) 0.07S-2.9". 13/4 c) 0.06t-2. 26 ag/4 «et vt SEil \| GEimi IlrOBMTIOS 1 1 feTle. Profile «f lealttT subjects. 1 Baseline data for determining ehuaes I in Batritiaml st«t« fro. industcial 1 fcod processing techniques. 1 I in ZSILIIE; UUIT5; PSTDE; nrurtS; 1 EIOOP SEBHH; HUB; KIDRTS; UTIt; I HLIti ISTIH: DIITS; FOODS; SOUS; \| TIGR1TIOI; CUHIOT: COVPIB; I BKGjiisi: inns: TB»CE zinnTS; I ZIIC i 1 >.) 1.T or - t.& ( »1 Bal«s uq/g l»et »t\| 1 l\ Mi«li b) 1.5 » or - D.B8 4 ng/9 (»et »t) 1 Tcoi a eaa qe «0.6 jr. paiales. 1 Man aqe 37.1 Tt. 1 1 mci niBins; itrropsiis: JIPII; I iltJilian; usmc; ciDUtn; coant: 1 CBBCBIUS; coEPtE: 1BOI; aiBcuai: I iiciuB; sicitsioB: IU&IIISE; I BdEIlini; (ITIIOBT: 3CHDIUB; I sninttg; TiiMioa: miDitu: z»c; I GCIE: BlOmt; Lit IB; KIDI1TS; 1 CIBMIUB; CtEIBEllH; II1BT; 10SCLIS; t IHCIItS; SPLEII; LOKS; JOBIi: \| IR11S; COIfiBlTin ETUTHIIOIS; SH; \| TOinSIC BIEICIII 1 a) 0.11 ag/g I <\| COfttcall b) O.'O I9/-9 \| t) lorter group It. 1 Controls. >?eB «3-72 yr, vko lived 50 1 k« fton tbe tactocj. sveieii. I stnn; ciciTHB: tiiwiis: HUB: t lines; comuTin ETHBITIOIS: I IIinSTBIll HTGIBI!; B!lSD8Htn 1 tmaos; trnsoBT; USHIC; ciositja; 1 CISIOR; cmtoeiai; COBILT; COPPIB; l ecu; IBOICJ urrmoB; LIID; 1 BI1GHISI; 11BCDBT; BOlTBDnOT; I iBospaons; BOBions; sci»Bim: 1 siitnan: SIITEB; TI»; roiosru: 1 tne; siuig BiziSTJs: itDosnui I EE1RS; SBIIIBBS; II1HJBIH1I 1 t«fte«. Tcotile at h«<b7 mtiject. 1 Eascline data foe deteraiaing changes I In iatcitio»l stites froa liliatcial 1 fcod processing techniques. 1 I in lEiuii: uaits; rnrus; nrans; I eiOOO SBHOB; BilE; KIDIITS: tHIB; 1 Bill; IITIEI; JIITS: FOODS: SOUS; 1 uenuioi: ciDBim; COPPE1; 1 mansE: inns: TBUE Eiznris; 1 UK 1 BEIEBBICI Gatkrle, B.E. Boblnaoa, B.r. 1»7» •e Zealand Bedical Journal i7 (603): 3-8 Takara. 1. Sazuki-taxanoto. 9. Inno, X. Teral, H. mo Iccbiies of InTlconnental Beltt 35(1\|:JS-44 Bcnne. B. •ardbeci, S. fester, P.O. 1480 Science of the Total EnTiEoment 16; 13-35 Gntfarie. B.E. Eobinson. B.r. 1»7I lev Zealand gedical Journal S1(S03):J-8 (HIT SISB) ------- m S«.»3»a, IP 12M C, BP 209$ C. It 1 n tg at 1292 C, 10 M B« at 1S10 C (OORIIOBD) tissis • 190 l»9 • Ifl l»«q «m lilk Bxpostn ion IIIITTICIL BRM0 U It latest loa •ram w cuts •) 2 14 2 •1 • tt 9 c\| 10 I1KI •) 0.39-0.68 «j/j (net •t) D) 9.09-0. 76 «j/g (««t •t) a) O.Ott-O.tl ««w b) 0.0015-0.60 19/9 c) 0.00 70- a, 31 g/g let «t •MI i etitui IIPOBUTXOI t nnsnici t 1 i i i i «) 0.5* * or - 0.21 1 «l Ida 1 Tifcam, I. ooyg (net »t) \| t) r«nles I Snaki-Tasuoto, 1. b) 0.«3 * or - 0.47 \| \| IUBO, I. •9/9 (««t «t) \| »co« * ?ro»p of f 1 »tep>le«, t T«r«l, s. 1 famatc w41nl «»laatlou, Japan. 1 180 I lalM. Han tg» »0. t re. F«Ml of I •«•> •«• 37. TC. \| CavicouHtal E««ltb 1 1 35(1\|:3-M I T»CC ntiziis; unotstsst ami; i 1 ttvnnf; Msnic; CIDSIUS: COMLT; i 1 cnoitivi; coFRi: in»; aiicsiT; I i mm: IISIBUIJ uvenisi; i I imoiDi; union; scmm; i 1 siinmi; tniiiaB; uuoioR: me: I I eotot stosni: IITBU tmiiis: i I ciimmi: c»niu.«ii inn: BOSO.ES: i I limits; spiEBi; lotss: totrti i t StTHS; COWlUnR (TUB1IZOS; SFI; I 1 ictnsic IUICIIB i i i I i a) 0.054 wg 1 •) CMtcol 1 Brail, D. b) 0,029 ag/g 1 t) lort«c elt«r 1 Scl«e« of the Total I >crt«r«, a4«* 55-76 rr, azpoMd to I JiTltoMant 16:13-35 1 l«ar? Mtals 1-3 tect&as. Ill* I 1 t U-72 ye, »bo lived SO I 1 ki ftoa the factory. S»ad«n. \| 1 1 t SIEBSI: cttims; riBtiTs; iirn; i \| IOI6S; COIHMTIVI XTltUTIOIS; I I IltlSTIIlL BTSIBIS: RtSniEBZIT 1 1 IfTBODS; IITIBOIIJ USKIC; C1DHVI; 1 I cisni: cnonvi; COBUT: COPFSI; i I GciD; itoi: iiirnna: iitB; i I Misirasz; incoiT; (rairBotxff: i I ttostamas} iraroiTS: sciiBimr.- i i snmrat SIITCT.- i»; mesni; i ( IIIC: IMlTf HIIIPS: KDOSTBItl I I pitits: siftms; Tsiiouoa i i i 1 »•«!•. Profile of aealth? najeetc. r ectkrle, B.B. 1 I»«liie data for feteniale? cbU4«> I tobiuoa, n.T. \ la ntcltloal «tit« fcoi iadwtrlal \| 1978 1 food ftoctia tockrlqves. I Wen Sealaad Sedlcal I 1 Joanal »7 (603): 3-8 1 in XBUiit: IBIITS: rrrus; nrtns; i I BIOCD sini; nit: noins: LITBI: I I mi: mm: Dim: FOODS: SOILS : t \| •HR1TIOI; C10IMB: CO»PEB; 1 1 tiietnsi: mils: ntci HtERzns; i 1 TIK 1 « 1 lint us 8) NJ O ------- 7»39-9«-5 II It! 5«.930, flt 121 C, B* 2095 C. W 1 •• Bg at 1292 C. 10 M Bg at 1510 C (CORI(IED) IISSBI 4191 BMCl* «19« VaKceaa Spiaal cerl XPOSVBE BOBtl IIU.TTICIL ntaoo 11 I 1 n X-^rar cpectcoe BBBBEI or USES •I • bt e a) 5 » 2 •1 1 W 1 cj 1 IMBt a) Bot glTia b) lot glrei a) lot glvea •b) 2.0-2.1 eg/g (Mt «t) a] lot applicable b) But applicable cj lot applicable (IIX1 BMB a) 0.28 * or - 0.21 •g/g (Mt «t) b> 0.33 * or - 0.29 ig/g (net ttj a) O.«1 « or - 0.37 •g/g (Mt «t) b) 2. 1 » or - 0.07 •g/g (»t rt) a) 72.3 eg/g b) 132.2 ag/g c» 1.3 eg/g Drr «t VIC1I SBI1B11 IBfOIfliTIOI a) Bale r) femlei ftat a groip at »1 titopilec. foreaele Mlical exaalaatloae, Japan. Bales, aeaa age «0.t 71. Ttaalo. aeaa age 37.* rr. iitci niBtits; imontxs: mai: iivnioi; amtic: CIOBIOB: CDBU.T; cnOBMB: CCfMI; I«01; BBICOIt; IIDXOI; BtfillSlOB; BIIGIBBSI; lOflDIOB: llHBOITi SC1IDIVB; snimi; TRiiioB; nuDXOBj cttc; soiB; Biotiit: inn: HDIHS; cnmni: cnnnxn: m«t: RDSCIBS; siicius: semi; towssj ioni; anus: COIPUITXTB ETIIOITIOBS; sn: fCCIBSXC BStKIlI a) lales t) reaale* Froi a groap of C1 aetepcle. f emslc aeJical eualnatlou. Japao. Balei. eeaa age M. C rr. Feaales, •eai age 37. ft. • Hici niBins; amoFmsi Jim; nanin: MSBBXC: CIDBIHII COBU.T: CHCBXDI; CQina; KOI; BBBCqst; IICID1; BieitSIOB: UIUIESI; BQVIDXBii: aiTXBOBT; SCllDXOt; sntinai TiuBioa; nnoxoi; zxic; CCIB; BtOBIlt: IXTBt: IXDIBTSi ciitBBin: czimuai; IXUT; tasciss: I1ICIBU; StllBli IOB5S; IO1H: IITILS; COBPUlflTB ITllVinOIS: SIX] retnnc aniciiB •1 aetoc Mitm alataie patleat t) Botor Miroa dlmeee patleat c) Control Teatral bera tlane, aMopai lo ietectable Ba la 5 otter patleat* aad 11 eoatrel* fatleats aied of arotrophlc lateral •eleroil. a) age 59 rr aaa b) <9 rr. Ccttcol, age M TC, U«A ftea Ing catclBoaa. THIS; IDUITS; tOTOtSISS; I'dtOHISCfltlB OISnSBS; SflML CO1D; tiokccnaBiHioi; citcma: COPPBC IIGI; LI1D; BlISallSBi BRI1S; sitnnas UK IBRUICI Telcava, B. Snaki-Taaaoto, B. laaao, 1. Tetal. H. 1980 krcalTe* ol CaTlroa«atal Health 35(1) :]«-«• T«k.a«a. B. Svzakl-Taaaaoto, B. laaao. X. Teral. B. 1980 ircalTe* of Enrlronaental Health 35 (1) : 3«-«« Eirluder, 1. 1. Mttea, B.a. 1979 lends of learologr NJ O Ul ------- langaaesa 7«3»-«-5 IB Itf !». 93BO, IP 12** c, 8P 2095 C, TP 1 aa Hg at 1292 C. 10 u Bg at IS 10 C (CORIIUSD) IISSIX »19« StlMB «197 arin« EIPOSOSS BOOTI IIUTTICIL IRIOD H US man OF casss ») 5 b\| 3 at 17 b\| 15 o 16 d) 7 e) 21 I) 23 a»6E a) lot given b) lot given a) lot gi»«l b) Rot jlv«« c) lot given d) »ot given a) lot gives J) lot given sua i esituL irannnoi 1 1 1 «) 0.1« * oc - 0.26 1 a\| 1tl«s •9/9 (oat «t) \| C) resales b) 11 » or - 9.2 ug/g I (••t wt] 1 Toi • groap of 61 autopsies. j forensic sedical exaBinatioa. Japan. I Balm, man age »0-6 jr. Pesales. 1 Mai age 37. 1 vr. 1 \| T11CI BIEBEITS; (ITOPSIBS; J1P1I; 1 «ic«irj«: nsETic; CIDHIOB; COBJIT: 1 cBnoann: COPPBB: IBO»: HEICOBT; \| IIDIVB; lUItSKTB: RU61IISE; 1 mBiDwa: iniioR: scroioR: 1 SILEHUB: TllUItn; T1UDIOI: ZITC; I GCLD: BIOBIK; tlTEt; KIDIEYS: I cisiBis): citEBCiLirg: HHBT: snsctss; 1 EiicBiis: sciBEi; Lines : loni: I IRalS; COBPIB4TITJ ETUDITIOIS: SKI; 1 fOBMSIC BEEICIIE 1 1 a) 0.95 og/9 I a\| Boys lltiof < 1 ki froa aaeltet creattniBe t fe) Sirls liviog < 1 In froa saelter b) 0.60 ag/g \| c) Orbaa boys craattaioa 1 9) Vrtai qirls c) 0.80 ng/ ------- Bcrcurr 7O»-»7-6 Bq lt» 200.59. IP -38.87 C. BP 356.72 c. »P 2115(8-3) aa Bg at 25 C, 100 an 89 at 260 C (CQItllVSD) TISSUE «» Biooa • 200 Blood • 201 Blood 4203 Blood, seres BIPOSIM tone Injectloa lagestion lagestioa Inhalation lagestioa lltLYTICll BETB09 US US •1 BOBEIE OF CASES 6 339 a) « B) 3 O « 1 B1BSB a) lot applicable b) lot applicable c) 3.6-19.3 ng/nl 10-167 ng/g a) 1.6-17.3 ng/g b) 3.7-8.5 ng/g c) 0.6-a.a ag/g Freak «t ) lot applicable b] lot applicable U1B a) 17.7 ng/nl b) 8.0 ag/al c) lot gifen - tot given a) 5.9 ag/g b) 5.3 ag/g c) 2.9 ng/» Fresh vt a) 115 ng/100 al b) 10 eg/100 nl 6IIEB11 mOMUTlOB a) liter 0.6 al/kq of gaaaaglobalin, 1 patleat as in a\| I) • iik after gaacoglobolii aed C-penicillaniM (2 gn/day) . 1 patient c) 5 patieats 2C yr old receiving gannaglobnlia. containing 0.01t •erthiolate (50.3 ng Bc/al). leceiveft «o-50 ng Bg/yr. ether patients receiving 0.6 nl/kg «»«y 2-3 rt, no Bg sensltlvitr. Pink, sealing, preritic palas and •olea. flashed cheeks, photophobia. irritability, treaor, altered sensation it fingertips, slomd nerve coadactlon velocity. BIICBIY; BHUS: SLOOO; TOIW; BUll PCISOIH5: BISSISTS; BSDO TBESlPT Ktlaated ficn graph. Ontario Indian «ho at coataninated fish. I1CCD; BIIB: BIBCOST; HETtlS; CMtDl; TOPIUTtOI BIPOSVSB; FISBBS; DIZTS a) CceapatlonallT exposed fc) In etposed area c) Snrgical ratieats Tegoslariaas, ages 1-63 ji. latapsies of at and b) . IIDflSTBIll POLL0TIOI; OCCOHTIOBU iinsDS: POPVUIIOI nvosmi; S01GEHT: BBiCUBI; RBBCOIT OBSW1C coaponos: TOSOSUTII; imopsiis; HOOD; Blim; KIDBBTS; UTIB; 10ISS; 1D5CL1S! SP1ZBI; THYROID GlliBS a) It adaissioa b) 1 no after dinereaprol therapy Dose, «30 ng nercuric chloride 5 ji old Beiicaa-incxlcan. ictonlul tain, malting, bloodj stool. Icite reaal failure HOOD SEBDB; HIBCOET; HTTHS; CBIIDXII; BIT11 POISOIIBG; CIS! EIS10IIBS (BBJI P1BZ1 ~ ~ KFIBIiCI Batheson, S.S. Clarkson. T.». eelfaat, E.8. 180 Joaraal of Pediatrics 97(1)s1S3-1S5 Phelps, S.I. Clarksoa, T.H. Kershav, I.G. Wheatley. B. 1980 Irchives of Environmental Health 35 (3): 161-168 . Itosta, L. Zelcako. T. Bavnik, T. levstek, B. Dernelj. B. Byrne, I.B. im Coaparative stadies of Tool anl Invironneatal Coataalnation. Proceedings of a Synpoaion held in Otanienl. Finland. lagnst 27-31. W73 Seiael, J. 1980 Pediatrics 6«(1t: 132-13* NJ O ------- 7«9-«7-« B* 111 209.SI. tf -38.? c. » 3S«.72 C, T» 2110(c-3) aa Hg »t 25 C, 100 « Bg «t 260 C (CORIBinSD) 1XSSSE «203 mi> »zw Bill «2« Brail «20C iraia Bifosm ton Xagestioa laaalatioa lageatiOa akalatiea lUimclI •ROOD •1 U sc IDBB1S or CUES •) s bj « 9 IHCB a) < or - 7.* ug/g (»»t «t\| b) < or - 3.1 119/4 (wet "t> C) < or - 9.3 «g/g («t «) d) 1.1-3.0 119/9 (wt «t a) 181-I3C7 ag/g b) 15-«1 ag/g, Fresh »t 1 ' ._ SO. 1-27. 1 ag/g frest .t lot applicable BE** \| GEtiiiL iiFotauioii I Birstncz I I I i a) 1.9 * or - 2.C 1 •) Rales, ceiebraa, * subjects 1 Yvkava, B. •9/4 (»et vt( 1 J resales, cerebraa, sabjects 1 Sazaki-Tastaoto, B. b) 1.2 * or - 1.5 1=1 Bales, c«rebellaa, C subject! I laaao, R. ug/g (»«t wt) I ') f«a»l»«, cvrctxllna. • aab]eta 1 T«r»l, B. c) 3.3 » or - 3.3 1 1 1980 '9/9 !•• >t) I Txoa a gro>r of f1 antopalva, I lrehi«s of 4) 2.2 » or - 0.9 i toravlc a»dlcal •xanlaatioa> 'apaa. 1 5BTlron««atal Eaalth ag/9 (>«t t) I Ralca, Mai •«• iO.C rr. P«aal«8, I 3S(1\|:36-M \| MH a«« 37. Tt- 1 I HIM niciins; inoniKi j»ni; i I imnroBj itscnc; CIDSIDB: COBUX; i i cnoiioK; COPPTI; IMC HICOII; i 1 linn: ainssim; msinsEj i I coixravi; iBixton; sciiDin; i \| H1EIIBS; TITlTIali TlIlDIdl: IIBC; I 1 eciOi Btoiini: IITXI; nvins: i I C»ZB(irt: CI1RBUOR; HURT; HDSCIES; I 1 i items ; spini: ittss; writs i I RR113: COBPU1TITE tT»L01TIC»S; SEX; 1 I FOlItS 1C BIDICIM 1 I 1 a) 1654 ng/g I a) occapatioaall; flfos»S \ Koata. 1. b) S3 ag/g 1 t>) la «iposti) arc* 1 Sclmko, T. rrash »t \| 1 Earaifc, T. I l«topsi«s, TngoaltwiMis, ages 19-75 f t«TStk. ». I jr. 1 D«ra«l], E. 1 1 Brne, I.B. 1 IlDDSTlIlI PCL1DIIO1: OCCOP«rtO»ll \| 197 1 BIZMDS; POPOUTIOS nPOSOBZ; I coiparatln stadias of 1 snaiBT; HIBcnii HSICDir CISIIIC 1 Food «»d Ialroaaeatal 1 CCBPOOIDS: TOSOSUTIl: inTOPSIKS: 1 contaaination. 1 B10OD: Btlll; KIOIETS; L1I1B; LOISS; t Proceedings of a \| ROSCLES; SPltn: TBTSOID Sums I SyipoBina beld la I 1 otaaieai, rinlanil, I 1 »»0.5 ppa total Bg I Saitfc. J.c. 1 1 1»81 j Caaallaa ladiaas, aertanest Oatarlo 1 Joaraal at Inalytiesl I \| Tozloolog; 5:90-9S I TISilS; toot COITHIUTIOR: I 1 ncusTtni rcLiimoi: POPOIHIOI i 1 [tposnti: itnii UEIS; BSBJI uus; I I >nn poitmo: aEBCDBT; BESCOBT i I c«si«tc coapcnios: Httn: Mmsis; i f IITEB: menu; SPLEEI; CIIIDI; i \| IROPStVS \| i i 1 i .9 ag/g \| MtopiTr 7 ac oil girl exposed to 1 Beatlako, H.I. I vapor. >A. 1 Toapklns. l.L. I I Soclaad. T.. I Peter, Toaltlag, pallor aafl dyspaei, I Baasoa, B.B. \| Colloved sevca days later by apoea. I Jactsos. a.B. I tllateral paeaeotlorax, seTere I 1981 I acidosisff coaaf selzarer aad .death. j Aaericaa Joaraal of I \| Diseases of Ctildrea I Parti! ateltctasls vitk s.alliig. \| l3S(t):«2-M 1 fecal atynleal hrperplasia, »ad I 1 l«qmantici of cells of alfeoli, j 1 alveolar daets, aad bronchioles. f 1 Byaliae acatcaaai, aad Latra-lveolti j 1 aeaorraages observed. Oeg««rative 1 I chaages la illB«T«. diMase fatty 1 1 ctaeges ia liver. I 1 1 I HISSlCinSlTIJl 40TOTSIIS; CUE 1 I Bisioms; iipins: RSTII toisonte; i 1 tiiii; icitius: tun: LOBES: i t incoit: must iiinmo i t i (HIT »»6I) NJ o ON ------- Mtcirr 73»-97-« •1 It 200.59, V -38.87 C, B» 354.72 C, »» 2110(1-3) u Bj at 25 C. 100 •• l« «t 2CO C (CORIIBZD) 1ISSBI »2«7 lair «joe lair •209 lair 1210 Bait inosmi VOTOB IikalaUoa Prwl kiumcu. anioD us » us 10BBX3 or cisss B\| 31 b] 22 2 2,32 •1ICI ) «0t glTII b) lot 4iT« •) lot 9l« b) lot gi»«a c) lot girti S) lot gi« } 0.2-2J.a* ppi b) lot giiaa e) lot gi»aa 1] lot glTan •) lot 9! TIB f) lot giiaa g) lot gif«B nai i cmm nrotuTxoi i a) 1» ppi \| •) l*ilg dlsatl«d b) IS ppa I k\| COBtral 1 1 tb arad 0tdits is c&ada. 1 I ciicivi: i»6Rsioi; POTissiOB; I SCBHB-. C It BIM-. COBU.T; COMBS: I IMI; MID; nieinsB; mcj i cnogin; insioi! IBICVIT; anus; 1 Bill: CSItltlll: ClllDl i 1 tfc«latt. Ib fastbllltT of a 1 belittle, io-«sk policf for hair 1 aialTiU It oitllMd a4 spportjt. I nnti; met ntnttsi uii; I IVSTlUIl: BJaSTIlMIIT HCTBODS: I iniis; ptornis: cwMtinn I ITllVkTIOIS; atOallOB; aiTIMIT; I usiiict itinit nonii: citina-. 1 ciiciui: ciieuii: craonoB: COEIII; I ccjMt; c ill MB: enunni: eou>; 1 UBiiit IMI: tiRBkvn: nit; I iintsni: MNinsi; BBSCVH; I miionoii iicrn; PBOSPHOIBS: 1 fctissni: SOTiura: SEIIIIDI: I miooi; sitmt SODIHB: siionm: i snroi; TII: iii»iio«: TOKSIBI; \| ZIIC; HKC11BB i a) 181 ppa 1 a) Cas* 1 - kad kale b) 11.9 ppi 1 c) Cas 2 - »«d kalr c) 16.8 ppi 1 c\| Cas* 1 - pabic kalr d) 9.» ppi \|d) Cas 2 - r«ble kalr 1 (cat lTls 1 1 Bntlsts, •» and SO yr old. 1 1 Tlio«T ttaaor, final OstviloratlOB, t imr BMiorr, IrcltabllitT, k«daeka. I Baicl palaa. anonila, nlgkt loss. 1 lieoordliatloi at llibs, Daam, 1 tipkorU. 1 I scoiuio; Kin nisoinej BUI; l inis; siBcniii mils: OCCDIITIOHI 1 IUIIDS; SBOKItG; DIFIISTtl 1 a) 2.19 ppi \| •) lsldBts of Sklkoki, ial« and b) 1.48 ppi \| Ciaal, all a»w, 1>75-1 »7« c) H3 ppi \| b) 7-9 rr old ials 4) t.W ppi \| c) 7-9 Tr old fnaln e) 1.2 ppi I d) 1-1S TT old ialB •) 1»-15 Tr old f) 2.83 ppi \| fcialaa q) 1.60 ppa \| f) 20-10 rc eld al«a q) 20-a« jr old GeoMtrlc mau I t«aals 1 t)-g) nsldcrts of Tokisfclia 1 rrfetaca, 1977 1 lgrlelt«rl area of Tokickia. Japan 1 >br Bg eoBtailiatloa Is lm than I «1amkt> OB the Ixlaad. 1 1 Jmt; attoltscEITl: » DOLTS: \|«I; I cntnn: six; Biit: ro»oi.inoi 1 IIPOSDH; BlICTIT 1 •nnnci riki, i.e. tart!, g. 1977 Seine* — — — — _____ _ Chittl«boroagli, s. 1989 Sdme* of tk* total lailtoaaalt la: 53-75 Sriiagton, I.S. Cross, J.D. Dala, I.B. Lcnikan, J.B.I. 1980 Jeorial of the Sociatj of Occupational Badleli* 30:37-39 SUioima, S. Kinca, a. •akagana, B. Tatao, g. 1980 tBVirona«ital B«suck 22:22-30 {lilt »»«) — - hO o ------- Bercnry 1««-9T-6 Bq lt» 200.59, 1 -38.87 C, BP 356.72 C, TP 2110(E-3) m Hg at 25 C, 100 BB Bg at 260 C TISSUE • 211 Bair •212 Hair • 213 Mart »21« Bcut iiposun son 1 l aninicii BET BOD US n l 1 » nsiis or cisss 339 a) 10 W « f B1IGE 2-52 ug/« a) < or « 1.1 ng/g (net t) ) < or • O.B1 ug/j (ret «t) lot applicable Bill \| CBIE11L rtTOlBAflOI 1 8EFEHEBCZ 1 1 1 1 1 1 lot gi»«n \| f«ir adjaceat to scalp. Estimated I Phelps. B.v. I frea graph \| Clarkson, T.». 1 \| Kersaav, T.O. \| Ontario iBdiaas »ho ate coBtaBlaated j »h«atl«y, B. I fih. I 1980 j I archives of \| HOOD: Bill; BEBCOBI; IET1LS; CM1D1; 1 EBTironBental Health 1 EOPDIITIOB iiposms: risBis; DIETS i 35<3i :i»i-i«s 1 1 1 1 I 1 r«»l«» of mrld llteratare OB the 1 Jankiaa, 0.. I acewlatloa nd blooanceatratloo of 1 179 \| nlectail toilc trace aetals in h»av 1 EPl-60D/«-79-tHt9, la j hair aaft nails aid other unallaa I pp. 1 talr, far, aalls, elaws and boat. I j latalatea by geographic area, j I objects, s age »0. 6 rr. Toalea, 1 Itehires of I IHD ao« 37.4 fr. I FnTironeenttl Bealth 1 \| 35(1) :36-M 1 TSICI SLisins: itrropsm; JIPII: I 1 HiBidiii: (PSEirrc: CIDBIOB: cosiic; 1 t CIBCSIO1; CCPPII; IBOf; BEtCDBT: \| 1 IICITH; aieiisioB; BMeiizse; i 1 I OB ID lU 9: 1IHBOBT: SCIIOIOB; \| I ;n.snvi: Tiiifios: TIHDIHB: xnc: r I eciD; BBOHIII: IITEI; noins: i 1 CIBIB101; CIBEBBltn0.5 ppe total Bg 1 Salth, J.C. 1 1 1981 1 Caaaiian ladlaa, northwest Ontario j Jonraal of laalytical I 1 Toxloologr 5:90-9« 1 iisais: FOOD ooiriBiiinoi: i I iiggsmii pouotioi: POPOIITIOJ i 1 IIPOSVI;: tnui «sis; DBBII 1B1»S; i 1 ntn poitniof; HSsaKT: BIBCDTI i \| CfCHIC CCSFC01B3: BE1IT; III1ZTS; I I tifti: rticim: spini; cinoi: i I ItTOPSIES \| (lltT PaGI) ho o 00 ------- lereory 7««-7-« It! 200.59. St -38.87 C. M 35C.72 C. n 2X10(1-3) u tq at 25 C, 109 •• Hg at 2«0 C 1XSSH 1215 Kidney •21C Kidney •217 Kidney (218 Kidney IPOS USE sans Ingestion Inhalation Ingestion lliLTtlCil. BETHOD U 11 U GC IUBSIB or CISES a) 20 b) 3 a) 8 b) 9 o » a) 5 b) 6 c) 2 1 IMGI a) < or - £.6 «g/g («et •t) b) 0.98-3.6 ng/g (vet «t) a) 0.05-0.027 ng/g b) 0.017-0.50 ng/g cl 0.01-0.47 ng/g let tit a) 5,500-21,000 ng/g b) 79-8.000 ng/g c> 30.1-364 ng/g fresh »t lot applicable Bill a) 2.0 » or - 2. a ag/g (net «t) b) 2.* » or - 1.3 eg/g (««t irt) a) 0.091 ag/g b) 0.10 »g/g O 0.06 ag/g Vet »t Redlans a) 12,224 ng/g b) 1,227 ng/g c) 197. »5 ng/g Fresh irt 1223. t ng/g fresh «t emiii nrotBmoi a) Bales t) resales Iron a groip of «1 intopsies. forensic sedical examinations. Japan. Rales, Man age «O.S yr. resales. neaa age 37.4 yr. 1IICE ELEflMIS; ITOOPSIIS; MPtl; itoaiina: iismc; CUBIUB; COBUT; CMOBWB! CCPPIB; isoi; BIBCOBT; •»iiria: iniBort: SCHOIOR; SIIEII1S-, TITHini; TISIDH3B; ZI1C; «OtD; BSOBI1I; LITIB: KIDI1TS; C1BEBBBSJ CltEBBLlOB; BElBt; BOSCIBS; EllCmtaS; S5IIM; IOIGS: lOITa; BJTIIS; COR11S1TITZ HiLDlTIOHS; SIX; ICIEISIC BEBICIIZ a) Control 1) lorker groop I c) lorker grogp II Kceased refinery and snwlter letters, ages 55-76 yr, exposed to keaiy totals 1-3 decades, tine tttveen retirement and death 0-1.5 yr it group I anil 2-19 yr, groop II. Controls, ages 3-72 yr. »bo lived SO III fron the factory. Sweden. sut ii: cioitras; EIDIETS; imi; HUBS; COBPJEITITE ETliniTIOKS; IVCQSTRIll BIGI2BE: HEaSOBBBEHT HITEQDS; MTIBOtt; USSBIC; CaOSMB; CISPJB; CIBOBIItl; COBUT; COPPEB: eOlD; IIOI; URBalDR: LEaD; (llOlKESf; BIBCOIT; ROITBDENH: FBOSPHOSOS; BDBIDIOR; SCIIDIOH: fllElIO!); SIITEB; Til; TOIGSIEI; zi«c: Bttna laiuis: noosmii FURS; SBEITE8S; TELLOaiDB .. a) Occnpationally exposed c) la exposed area c) Controls Tgqoslatians, ages 1«-7S yr. Intopsies. IIDW3TR11I POLIOTIOI; OCCtJPITIOJII. Hl^lltDS; POPQ11TXOR EIPOSORS; SUBGEHT; BtXCDBI: "IEBCUBT OKOiHIC CCiPOOBDS; TdGOSLIITII; iBTOPSIBS; HOOD; B«»II; !tID»BIS; 1ITE5; IOHGS; BDSCLES: SPL1EH; TBI8OID G1IIDS Intopsy, regular consnner of fish containing >0.5 ppn total flg Canadian Indian, northvest Ontario FISHES; FOOD COffitlBIUTIOi: naosTBiu FciioTioi: POPOIJTIOJ II?OSOBY: BOBII IREIS; IBBJH IHJIS; nits potiinio: BESOT ai; aEscnn Cf5»lIC COBTCmiDS; BE1BT; XIDRETS; tlTEB; P11CIR1; SPLI'S; CH1D1; 1ITOPSIES itnincs Inkaia, B. SaTtki-lannoto, B. Isano, K. Teral, B. 1980 Archives of Environmental Health 35(H:36-«» Brane, D. •ordberq, G. •ester, P.O. 1980 Science of the Total InrironMat 16:13-35 Kosta. 1. Zelenko, T. BaTnik, T. levstek, B. Byrne, l.B. Coaparative Stadies. of Food and Earlron.ental Contanination. Proceeiings of a Syaposina held in Otanieai, Finland, ingvst 27-31, 1973 Cappon, C.J. 5.1th, J.c. 1981 Journal of Analytical Toxicology 5:90-98 (Hit PJSI) K) O ------- ttreaty 1M 200.59, B* -3«.«7 C, B* 356.72 C, va 2HO(E-3) aa Bg at 25 C, 10O aa 89 at 2«0 C CCOItllOBD) II9SBI «1» (idaer «220 liver (221 Ilrer lirOSVM BOOT! laaaUttoa aiunicu BCTBOD U 1 I 1 U 1TJHBM OF CaSBS 1 •1 5 M 7 1 1 i 1 a» 8 b) 9 ct * niai lot applicable •) < or - 1.7 »9/9 (Mt vt) b) < or - 6.0 vg/g (net •t) - - i t ») O.Oie-o.l* no/? b) 0.016-0.10 «9/a c) 0.01S-0.13 09/9 let at nil \| GBIZIll IirolBlTIOB 1 12.2 09/9 \| latopsy, 7 ao old girl exposed to I vapor, 91. I 1 Tever, vosltlag, pallor and dyspnea 1 fellowd Mvaa dare later by apiea. 1 cilateral eaeasothorax. severe 1 ecidocis, coaa, aellare, aad death. 1 1 fartlal atalectaais «lta svelllag. 1 fecal atypical ayaerplasia. aad \| deagueatiOD of cell* of alveoli. \| alveolar deets. aid bnwchiolei* \| Byallae seatraaes. aad imtra-alvcola f ctaaoas la tldaey, Jiffase fatty 1 caaage la liver. 1 I gissiCBtsms; IUTOMIES; CISB \| tlSTOKBS; ItTlaTS; Wilt WlSOinC; t iia»t KiBiirs: IITBII loves; \| BJtCOlI; BHllS: IBBEL1TIOB a) 0.60 » or - 0.70 1 «» Bales 39/9 (vet vt) ( t) Tevales b) 2.3 * or - 2. • ) ao/o. (vet «t\| \| froa a groan of 61 aotopaiea. \| foreasic cedlcal eiaalnatioas, Japaa t Bale, aaaa ae «». 6 yr. Veaales, t aeaa age 37.* yr. \| TB1CI nSBBBTS; UKOPSIBS; JUII: 1 tiraim: ustncs ctosion: COBUT; I cnoiiai; copRB; isoi; aBBcnxy; j UOIUB; BlGBESIBBi IIIGIIBSB: 1 usiDins; airiHOaT: sctanma; 1 siLmos: TiTinw: THUDIOS: tire; 1 eoiB; BJOBIII: urn; n»»iys; I CMinvii; CIIBBZUVB: BBaBT; BOSCLZS; \| 'IICBI1S; SP1BZI; IOKS; lOBTai \| IRalS; COBFIBITITI BTUDlTIOaS; SKI; \| VOIIfSIC BFCICIM 1 \| a) 0.037 nj/9 \| a) Coatrola b) 0.03* 09/9 \| b) Worker groap I ct 0.037 eg/g I c) Vorter groap II «et vt i Sediaas \| tteeased refiaery aad acelter j vorkers, age* 55-76 yr, exposed to I beavy aetala 1-3 decades. liae I r«teea retireaeat and deatb 0-1.5 yr 1 Ja aroap I aad 2-19 yr, group II. I ceatrola. ao.es 13-72 yr, »»o lived 50 1 ka froa the factory. Svedea. 1 1 sum: cturas; cirans; urn; \| 1D65; CORfaBtTlTZ ITIU17IOIS; 1 IltOSTtlll BTfilZIS; BSlSOnBZBT I BTTBODS: miBon: usnic: caDRioa: t cuwi; cnoanrii COBIIT; COFPEB; \| fiOID; IBOV; UtTBJIOS; IBaD; 1 •iieiiisi: incoBT; BOLTBDMOTI: I iBospBoias; BIBIDIOH sciigitm; I sitinra; sum: tii; Toissni; 1 me: IIIITB uiuos: novsTBiu i titns; sniTns: -numis i IBFIBEBCE 1 Boatlabo, B.C. Toapkias, a. I. lovlaad, T.I. Baasoa, B.B. Jacksoe, 1.8. 1981 itericaa Joantal of Diseases of Ckildrea 135ft] :<2-4« y«xa>a, a. Saiaki-Taanaoto, B. aaaao. K. Teral, i. t»80 archives of Bavironaeatal Bealtb 35fl\|:3-«a raae, D. ordberg, S. ester, P.O. ego cieace of tie Total aviroasent 1C 213-35 (MIT t»SI) ------- earcarr 7«3»-»7-« Itl 200.5.. ' -3. 17 C. tt 356.72 C, TP 2110(1-3) SB 89 at 25 c, 100 aa Bg at 260 C (COBTZinEB) nasai 122] liver «223 liver 4224 liver •225 laa« EXKStBE BOntX lagestioa XabalatloB lakalatlo. niimcii. «WO» n ec „ B08BEB or cuss a) 5 b) « c\| 3 t 1 «) 3 b) 2 I1KE a] as.711 Bg/g b) «1-1«» avg !) Is.s— 48.B ag/g fresh «t Bot applicable lot applicable a) 0.28-2.0 ni)/g (vet «t) b) < or > 0.06 ag/g (wet •t) BE1B a) 250 ag/g b) 99 ag/g e) 34.5 ag/g Presh vt 14 5. 7 ng/g fresh wt 5.1 ag/g ) 0.17 + or - 0.9B ag/g (vet t) b) O.OJ or - 0.04 ag/g tvet vt) GSIIBU IimilTIOl a) occapatlcaally exposed i) IB expose! area c) Costrols latopslet. Taqoslaviaas. ages 1S-7S 7t. IIOOSTtlll PCUirtXOB; OCCVMSIOIU BataBDS; POPVLaTXOB EXfOSOvBj snenr; ancmi; mem* oismc CCBJOBI&S: TuaosiiTH: movsiES; HOOD: BttiBt KiDnis; iifii; Lmes; BQSCLBS; SPIEBI: TBTBOIO QlaVOS litopsT. regalar ooasaaec of fish eeatalatag >0.5 ppe total Bg Caaadlaa ladlaa, aorthvest Ontario iisns; n>oi coRuxuTioi; IBDDnSIll JOL1DTIOI; POP011TIOB IIPOSUH; tttBaL MlaSJ DBBIB UMS; IKCT ponutioi: TBscosi; aiscoii ciGinc coiMviDS: HWBT; KIDIIISI lITIt; FLlCtni; SPIESI; CIIID1S latopsf, 7 ac old glcl eipoaed to vapor, la. Kver, voaltlaq. pallor a ad dyspaea. followed sevea dar« later bv apaea. t {lateral pienaotboraz. severe aeidosis, cosa. celxare, aid death. Partial ateleetasls vita mil lag. focal atypical kipatplasla. aad desgnaaatlca of cells of alveoli. alveolar dncta, aad ferotchioles. Bfalia* Beatzaaes. aad latra-alveolar aeaorrhages observed. Degeaeratlve ciaages la kUaeTa, Uffnae fatty ckaages ta liver. MSSacmstns; inorsxES: cisz BISTOSIE3; TirilTS; BSTtl POISOBIIS; tllll; KXEltIS: 1ITEB: 1DB6S: HlCmiT: BPI115; nBallTIOB ) Bales I) Tvsales Iraa a groap of 61 aatopsles. forensic aedlcal exaaiaatloaa. Japan. Bales, aeaa age aO.« yr. reaales. aeaa age 37. rr. TVICE I1EHIIS; iBTOPSIIS; J1P4I; iioBiiiji; t«smc; CWSHJK; COBUT; CBSCB1U1; COfPElj IMI: HBBCOBI: ncran: iiisiEsniB: IMGUESE; lIBIEItl; iniBOHI: aCMDIOB; SltMUPI; TIIMigg; VIIIDIOB; ZXC; COLD; BIOBUI; inn: KISBBTS; ciitaim; ciBEB'iitifl: IEIIT; nnsais; IIICBMS: SPLXEI; lOKS; aOBTt; VI1I1S: conaakTITE EfUDitloas; SEI: fCIIBSIC RIDICXK (IIXI PIG!) IETEBBBCE Kosta, 1. Celeako, v. Bavalk, T. Levstsk. 1. Seraelj. 1. Byrne, I.I. Cosparatlve S tidies of Pood aad ZDVlronaeatal Coataalaatloa. proceed ings of a Syaposiua held la otanlssl, TlslaB.4. avgist 27-31. 1973 Cappon. C.J. Salta, J.C. Joanal of laalvtical Toxicology 5:50-98 •oatlako. B.E. fOBpklas, l.L. 8o«lt«d, t.». Baasoa. B.B. Jacfcsoa. ».H. laerlcaa Joaraal of Diseases of Cbildrea 135(1) «a2-« Tokava, B. Sazakl-Iasaaoto, B. liaao, I. Taral. B. 180 arealves of Zavlroaseatal Eealtb 35(1)! 36-44 ------- tttevij •s itl 200.59. IP -38.87 C. BP 356.72 C, vp 2110(1-3) u Bg at 25 C, 100 •• Bg at 260 C (C01TH1EO) IISSOS 4226 lug «227 Ian? • 228 I«g t EXPOStJIE BOOT! lagestioa Inhalatioa lakalatioa I iiaiTTicii IBTBOB n 10HBKS or cisss a) 8 b) 9 C) • «) 3 bj 5 1 1 1 B11GB a) 0,0010-0.17 mg/g b) 0.018-1.13 og/g C) 0.012-0.097 »g/g let lit a) 127-1510 ng/g 1) 12-271 19/9 Trash vt lot applicable iiti \| GIIZUL nroEaiTioi i miBBici I 1 i i I I a\| 0.000 «g/g I a) Coatrols \| Prase, D. b) 0.031 og/g I b) vorker groap I I loraberg. G. cl 0..038 ng/g \| c) Worker groap II \| tester, P.O. let t I I 1980 SediaBB t tseaasea refiaery a ad saelter I Scieaee of tbe Total \| loiters. «q«» 55-76 TT. «rpo««a to I ZniroiMnt 16:13-35 \| I««TT Mtals 1-3 decades. Time I \| tctveea Tetlreseat ad death 0-1.5 re 1 j it gtoip I aid 2-19 jt, gconp II. 1 I cmtrols, aaes 43-72 jc, vho llwd 50 I 1 ki froi the (aetoCT. Snedea. 1 I sncEi: cioitnsi XIOIETS; LITXI; i 1 IHIGS: coHPiiiTire BTILOITIOIS: i I IIDDSTII1L BIGIEIK; niSOEIBZIT 1 \| BIIBODS! IIIIHOIT; »5»IC: C1DB30B; \| 1 CISDB: CMOBIDI; COBU.T; COPPBI; t 1 SOLE: IKOI: unuiiB: HID; i 1 iiismsE: BZtcnBi; HOIIBDBIOH: i 1 ftOSPHOIUS; TOBIDIHB: SC11DIDH; \| \| 51LEIHTH: SIITJB; Til; TOI6STEI; I I uic: BIHTI Hizuas; IIDHSTBIH i \| EI1RS; SBS1I1RS; TEUORIDR 1 1 1 1 1 a) 77t nfl/g 1 a) OccipatioMllr eipased 1 Kosta, 1. b) 131 n 7 1C old girl exposed to 1 RootiBbo, H.E. I N3 ------- Bercarr It! 290.54, IP -3I.IT C. » 3SC.72 C, It 2110(1-3} an «g at 25 C. 100 an Bg t 260 c USSBB 1229 laacte 4230 1231 tail ET.KOTH HOOT! Xaotstlon Inhalation Ingest ion Inhalation Oeraal 1IUTTXCU. BZTBOD n n Bl IOTSIS OF ClSIS a) 6 1 » a> 3 2 E1WI ] < or • ».« »g/g (»«t t\| b) lone aetoctftd' a) (.5-106 ng/g b( 1. 9-2* H4/9 Fresh vt a) lot giT«» b) lot given c) lot given 4,1 Hot ?U«t BB11 \| GHESIL IIFOBBUIOI 1 a) 0.77 or - 1.8 1 •) tales eg/9 (vat vt) \| t) Fe aal«s b) Kane detected \| j Iroa a groea of 1 autopsies. \| forensic aedical oxaniaatioas, Japan. \ Bales aeaa ao^a 406 vc» F«»a,Vs, 1 aeaa age 37.4 vr. \| TtlCl ILIB1B1S; JOTOPSIISJ JIP1I; 1 itunnm: tesEiic: CIDHIOB; COBILT: \| CESOBlai; COIFEB; ItOI; HSBCUBT; \| IIUIBB; IISBtSKIl: MIGUISC: 1 euBiDirn; iiiiutPir: SCIJDIDI; I SIT. MTU": TIttBItrg; tilaOIUB; ZIIC: I 6CID: BBOBI1I; 1IVIS; KIDHTSi I CIBIBSTS; CIEEBEiina; BSUI; HHSCLSS; 1 PiicEiis; sritia; loBss; toni; 1 amis; COHfHtTITE lllD«IOaS! SIIj 1 ICBItSIC BEDICIITE 1 a) «3.5 ng/g ( a) DecapaticnallT «iposefl b\| 1«.0 ag/g I t) In «zpos«a area Fresh vt I t latopsies, tagoslavia, ages K-75 yr. \| t IKVSniU POIIBTtOI; OCCnTtnOML 1 BII1SDS; POPOtiTIOl HPOSHSS; l smsEii; nrtcusT; IUCQBT assuic 1 COBPOIigS; USOSLITH; tUTCPSIES; 1 HOOD; B1IIB; KIDfEIS; IITEB; LOIGS; 1 stsciES; spirei; TIYBOID eims l 1 l l a) «9S ppa \| i) Case 1, fingernail bl 313 ppa \| t) Case 2, flag«rMll c) 17.1 ppa 1 c) Case 1. teenail 4> «.S 5?» ( S> Cue 2, tcevall 1 leak levels 1 1 Dentists. • nd so vr oil. 1 1 linger treaor, vlnal deterioration. 1 [oor aeaory, irritability, headaches. 1 nisele pains, aaocezia, veight loss. 1 lacoordlaaticn of llabs, nausea. 1 euphoria. 1 1 sconiiD; aiTii FOISCIIKG; BUS; l unsi aiBCDEi; IIETIIS: ocetPiTiosiL 1 BiiuDS: stems; DMTISTI-T AEFEBZICE Tokau, B. snnki-Tasvnoto, 9. laano, K. Terai, a. 1980 accVives oC Zavlronneatal Eealth Kosta, L. Zeleako, T. lerstek, B. Darnel j, g. Byrne, I.E. 197* Coapacatlve s^vdlos of Food aid Eavironneatal Contaninatlon. Proceedings of a STapoaiae held in Otanleai. Finland. Kigast 27-31, 1973 Svnington. I.s. Cross, J.D. Dale. I.a. lenihai. J.I.I. H80 Journal of the Society of Occupational H«Ucine 30:37-3* ------- BcrewY Itt 200.54, tt -M.tT C. tt 3SC.12 C, » Jit 0(1- 3) aa Ig «t 25 C. 100 » 19 at 2«0 c (COBTIBPED) TISSVB «232 tail «233 •»il •23* Patcreas sxtosviB ton •IU.TTICU nraoo u u •rani or cuss a> 9 b) It 7 3 tlKC •1 Mt aiT«» b) lot «!T«« a) < or • C.«5 «9/j (Mt «t) b> < or - 0.81 09/9 (»et •t) BEM i GiBitit XBroiBiTicir i scnazBcs i I i i I 1 r*tmt of meld llt«c«ttr« o the 1 Jmklai, 1.1. I accaialatloa aid biocoKftatratloa of I 1979 1 «lct4 toilc tr«c« a«t»la in bnaaa 1 lM-«00/»-7-0»9. 18* j kilt »4 mils »i othr aaaaallaa 1 pp. 1 aalr, (»c. Mil, clan* aaft boots. I 1 I»fc»l«t»d by 7«9Tltbf 20-60 TC alia I Uastlfaon, P.S. 1 \| »«l»oo. 9.1. l itnits: szi; mis; BITIEB ; iionmB; i Boor, c.c. l mnaiTi HSBixc: S»SWB; cmatOT: I 1979 1 citcim; ctsnw: CBIOHOB; ccaiu; i sd«»c« of the Total 1 CCPPEB: «»(invc SCUD; IBO«: HID; 1 Zarlroaiut 13:131-10 I S1GIESIU1: BIKAIESB: RSBCOBTi 1 I (ciTBDinB; nctn: rotission; i \| lOBItm: SIIBIIIH; SIIICOB; SILTSBi 1 i sorrow: STtcirrtrs: TIC Tinrrua; i I tJUDIOB; MIC; IIBCO1IDB 1 1 1 1 1 a) 0. N or - O.IT I <\| »«Ie» ! Tak9», B. •j/j (»«t «t) \| 1) F«»ls 1 S»t»lcl-T««m»oto, g. b) 0.27 » or - 0.«7 I 1 laaaa, K. 19/9 f*t t) 1 ttoi * ?ro«p of SI avtapci*, 1 Tri, B. 1 farcaslc i«41cl azaitntioie, Jip»». I 1980 1 Bales, Mas »9« IO.C yr. P«a»l«s. 1 Irchlies of 1 i«» 9« 37.* TT. 1 EaTtcoaavatal 8altb 1 1 35{1):3<-« l Tiict nsiizns: tmorsits: JUIB: i t iiBBina; iBsnic; cioatna: COBU.T; i l ciioiUBB: ccmB: IBOB; BEBcrai: i 1 113t08t BIGBCSXIK: B1B61VESB; 1 i inttma: iniaon: SCIBHVB; i l siisnos: tiUBioa: nitDiua; IIBC; l 1 COID: moBiii: insi: nvtzts: I I ctiiBtoa; cnniuoB; mm-, suscies: i 1 flBCIMS; SFtSSBi LVKSi 1OIT1: 1 l ------- 7«39-97-« •« It 209.59, -38. 97 C, BP 356.72 C, TP 2110 [1-3) u flg It 25 C, 100 M Hg «t 260 C TISJBB »23S PitaitatT • 2J« Placenta W3T Stleea Spleen •239 Spleen SIPOSIJU tOIRE . Ingestlaa IBkalatlOa ifiimcii BTSBOH 9C n » sc EOT in OF CISIS * s 3- at 9 b\| * •1 3 M 2 1 U6I 19,000-C«.Oa4 a«/g 163-23,900 ng/g 6.V-63.6 »g/g nab «t 2.0-20.7 ng/g fresh «t at < or » 2,1 »g/g (met >) < or • 1.S eg/g tet •t} a} 23-188 Dg/g b) 11.8-20 ag/g Fxeh Vt ' lot applicable IE i i esiEtu. urosiiTioB 1 •.6,000 ng/g 1 $.225.* mg/g 1 SBC'S •4/9 i Iv^oslwimSf &STt: l Biiiis; cogpiMTifE ETiiaincvs: sir; 1 KBEISIC BtCICIBE 1 a) 79 ag/g 1 al Occvpetlaiallf -exposefl b) IS. 9 ag/g i fe) In expoitd araa Fresh vt \| 1 latoislaa, TBgoilarla, ages H-7S TC. 1 I1DOSTTU11 PCLtVTICB: OCCOElIIOIll. I BtllBOS; MPBHIIOI ZIFOSOBS: 1 SOtCZBT: BJSCCST; BBSCOET OBCUK I CC1WTI1DS: IBSOSLITII; IJTCPSieS; I noon: mil: Kisratss mis: LOTOS; I HSCLESl SfLEEI: THTBOID GIHDS 1 1 t 1 80.* ag/g freu vt I latopiT, regalar oos»er of flak I cc»t»lal»q »O.S fpm total Eg 1 Caaadtaa ladtaa, »ortk«est Oitarlo 1 I ftSBES; FOOD COMlHIBlttOI; \ IIOQSTItlftI, fQtd>mTOl BQ¥1Ht>TIOV. l IIPOSDRE: «OBII nits; TOSH isiisj 1 flTEB POttBTIOI: HEBCUSI: HMCtlDI l cismc canpomros: BBIBT; KIDIEIS: 1 II1R; PtlcBBIi; sPlEEr; CUUDI: i lEnmcz KOBta, I. Zeleato, T. BtTBiX, T. leiatek, B. Deraelj, B. BTEB«, I. S. 1»7< CoapacatlTe studies of rood aad EiTlronaeatal coataalaatloa. Proceedings of a Syapotiu held la Ctaaleal, riolaml. aagvst 27-31, 1973 Cappoa, c.j. Salth, a. C. 1901 Joacnal of Inalrtlcal ToxlcologT S:O-38 ... Tukava, S. Saickl-Iasaaoto, a. laaao, K. Teral, B. 1980 acclilTes of EaTlroamntal Health 39 (1) • 3i— %l Zeleako, T. Bavaik, T. levatek, B. BrcaJj''!.^ 1974 Coapar attire studies of food aad Eaviroaaeatal coataalnatlon. Procaedlaga of a Srapasioaj held in ctaaleal. Finland, iarjiut 27-31, 1973 Cappoa, C.J. Smith, J.c. Joacnal of Analytical Taxlcologr 5:90-98 ------- tticw 7M9-97-4 Bg Its 200.5$. I? -38.87 C, BP 3S6.72 C. It 2I10(B-3) u Bg at 25 C. 100 •• Eg at 260 C (COIIIBED) iissat »2»0 Thyroid gland • 211 Dtiae «2»2 Orine «23 Ori« iirososi BOUT Inhalation Ingest ion Ingest ion ejection 1 t 1H1TTICJU. BETBOD u us us BHRBEB OF CIStS a) 5 b\| 6 0 3 d\| 6 1 6 6 < 1IIGI a) 21,300- HI, 000 ng/g b) 69-26,500 agyg C) 2.5- 15 ng/j 4) 7.1-507 ng/g msn vt •} lot applicable n> lot applicable - ) lot applicable ) lot applicable ) 23-66 ng/sl 5. 80-25. OD ag/2» hr <1. 0-2.3* «g/2« br Bin i GEBIM.I nroiauioB i sntsstcs 1 i i i l l a) 51,222 ng/g I a) Occnpatiosally exposed I Xosta, 1. b) »8»2.5 ng/g 1 t) In etposel area I Zelento, T. c) 10.2 ng/g I c) controls I Ravnilc, T. d) 11* ng/g ) d) sorfieal patients, one of ban \| terstek, B. rresl «t 1 Dotted »Jth Eg and kai kigbest tissue I Decnelj. 1. I l«nl. \| Byrne, i.1. 1 1 t»7» ( I agoslariaas, ages H-75 yr» \| Conpacative studies of 1 1 Contamination. ( IIB5STSIII POUBHC1; OCCIMTIOUI, I Proceedings of a \| BJZ1SDS; POFOUTIOI E1POSD8I; \| Synpoalnn held in 1 soieiBT; BiEcoBT: siECtrar OEGHIC i otanieni. riniand, \| COSEOB»OS; roOOSIlTIl; 1BTOPSIJS: \| Jognst 27-31, 1973 I EIOOD; BB»I»: KIIRTS; LJTSB: LOTOS; \| \| 80SC1ES; SPHEI; THTBOID CtalDS 1 1 1 a) 90 ag/1 I a] It adeission 1 SeUel, J. b) 1330 ag/1 I B\| Hospital d»T 2 1 1980 \| rose, 9S9 sg sercncie chloride 1 Pediatrics \| I 66(1)! 132-1 3« ] «.S TT old Bciicai-tMrican. I 1 1 I Tesiting, abdoiinal pain, diarrhea. 1 1 1 \| Cloodr stools, protein aria I 1 1 \| CIIIE; 1XBCOBT: BCTltS; CBILCSI1; \| \| Hill POISOIIIS: CISE HISTOBHS \| 1 1 1 1 a) 63 ng/il 1 l Ifter 0.6 il/kg ga»aglobulii, f I Rethesoa. D.s. b) 138 ng/nl I patient as In a) I clarkson. T.s. c) lot given \| t) Ifter 2 on/day I>-penicilla»ine, 1 \| eelfand, E.I. \| patient, peak at 5 dars I 1980 \| c) S patient I Jon nil of Pediatrics \| a) end b) estiuted free grain 1 97(1) 1 153-155 1 29 TT old reoeiTing gaunglotalin, I I contaiilnff 0.01V nertbiolnte (50.3 eg I 1 Ig/nl\| . leceired »a-so sg Sg/rr. 1 I ether patients receiTiig 0.« il/tg 1 I <err 2-3 ek. DO Sg sensitivity. 1 1 lint, scaling, pnritic palu and 1 1 soles, flnstcd cheeks, piotophotta, I 1 Irritability, treeoi. nltered I I sensation in fingertips, sieved nerve I j confection Telocity. \| l BticDiT: BRits: BLOOD: miE: ssin \ ( EOISOIlfG: DISE1SES; DEUS 1BB1PT I 1 1 1 1 13.65 >g/2« hr I a) taw»aki disease patient 1 orlovski, J.p. lot given 1 t) Controls I fiercer, B.D. \| ) 1980 I 5- 11 yr oldi, vitb. (avasak.1 disea.se, 1 Pediatrics I and controls. I 6«(«\| :«33-636 1 1 I Terer, con1«Bctlttln, pharyngitis, 1 1 trTtnenn, trescal enntnen, cerrlcal 1 \| idenopitky. 1 1 1 1 iiKgiT: inns; ntu. poisoius; i \| CHID1CT: OBHI; OISEISE3; CIS I I \| fISTOBISS t 1 1 inn ------- Cercarr 7»39-«7-S »t¥ 200.59, BP -38.87 C, BP 356.72 C, TP 2X10 (E-3) am Hg at 25 C, 100 aa Hg at 260 C (COiniHED) HSSM Urine »2«5 Urine Urine IPOStJBE BODTE Inhalation aiunicu mioo us us •BIBE1 OF C1SSS 6 «) 70 b) «0 1 1101 a) 0-15 eoyl tt 16-30 oj/I c) 31-«5 «g/l dj »6-60 ng/1 «1 > or 61 a«./l a) 0«OOV-0.«565 no/hr b) 0.007-0.185 ng/hr a) 0.007-0.614 vg/hr b) 0.005-1.«01 ng/fcr c) O.OOt-0.565 egAr Bill \| GEIEBH IlFOBBaTIOI 1 1 a) lot given I a] 3 patients b) lot given I t) » patients el lot gives \| c) 7 patients t) lot given I it 9 patients e) lot given I •) 3 patients \| Bg dosage of «-73» ng (nean 1S7 >g1 ( G). ovec 6 ao-17 vr (nean 6.5 vr) . \| -C7 TT olds «ith \| 8IBCTBT; HFTILS: US III; DISEASES; \| CIKOTBIHP1 a) 0.076 » or - 0.012 I ) Controls rea b) 0.110 * or - 0.020 \| ag/hr 1 lonea. aesn age (2.3 Tr. fron (S.E.) \| Cd-eollated area (Liege), and I controls, nean age 01.1 vr. fron I Charlecoi, Beloiaa. 1 \| BIOOD: BLOOD PLaSIt; Q1IIE: C4BBIOB; I mo; asecust; tiic: BEIILS: BIIGIOB; t is!-. popTamoi Exrosvis: IIDHSTBXU \| tCLLDIIOl: SBIITEBS; XIOIET KStlSSS t a) 0.065 ag/hr \| a) Besilents of Liege (cost pollute* b) 0.057 ag/hr 1 area) c) 0. OM ag/hr I t) Besidents of Brassels (less Seonetclc \| icllvted axea) 1 c) tesideits of Charteroi (control 1 «•«) I leans and ctmlative freqaemcr 1 distribaticns not neck different I tetveen the three groups 1 Bsaltbr sablecta >60 ji old. I iesl4eat> of the sane areas 25 vr, I Hlgina \| EIIGTUB; ICBLTS; aSE; BLOOD PllSHi: 1 DBiit; c» cnioB: LE»D: BIBCOII: 1 IITM.S: me; IIDHSTBIU EBISSIOIS: \| tlDHSTBIll PCLLOTIOI; POPOUTIOB 1 IIPOSmtE; IBBtl 45BIS SEFEBEICE RaeaCT, H.B. Carter, 5-F. Teaian. ».B. Thompson, B.a. 1979 British dedical Journal lanervs, R. Boels, B. Bernard, i. Bucket, J.P. 1980 International Archives of Occepationa 1 and Environmental Health «5;271-27« Boels, B.l. Laaverys, I.E. Backet. J-P Bernard, ». 1981 Eavironnental Besearcli 2»s117-130 Bercnrrtl), Mtkrl-. ion (8 CI) •erc«rni»), »etnil- J9 CI) 22967-92-6 C-B3-Bg II 215.63 IIS5BB •27 Blood EltOSDBE EOHTE Inhalation - 111LIIICU. BETHOD U oc iraBza OF USES 11. 17 controls EIBGE a) 67-518 ng/g b) 100-15* tig/g c) i.5-69.5 ng/g d) 1.9-13.7 ng/j BIT »t (HIT REal a) 227 no/g b) 129 ng/g el 27.0 ng/j d( 5.7 na/j Dry »t P1GB) Gllntl IIFOBI1TIOI a) Total Mrc«cy, dantista t) Total aercvrr, non-exposed ccntrols c) dethrlnrcnrv, dentists 6) BetkTla«rc«rT, aon-erposed ccntrols Significant difference at P < 0.095 level. viitto KIIGDOB: IOOITSI BIOOB; CtHTISTBT: tEBCOSI; REKCOBT OSGIHIC COBPOHIBS: Eioiccginunoi: CCCOPMIOflt B1TISDS BEFEHERCE Cross, JD. Dale, I.I. eoolvard, L. lenlhan, J.a.i. Smith. B. 1978 lancet 2(80811:312-313 ------- larcarr(1»>. Mtkrl-. ioa 18 ci) aerCeTTd!. a»tkyl- f9 CI) SJ96T-92-6 C-B3-Bg II 215. S3 nssa «2M (rail 424* Brain «250 laic 4251 ••art «2S2 Ildaey ZIKSDBB MOT laoastlon lakaUtioa Ingest Ion Ingaation Inhalation gestioa estion •latin 1I11RXC11 8 FT BOD n sc u sc t IDS EH or cis: 7 9 T Ufa 2-26 ns/» freak it 17.9-1t«.0 ng/g rresk vt 270-1030 »g/g freak «t ot applicable 26 ag/g freak «t IEII i eniiii iiFomtioB i IERIIICB i i I i 9 ng/g fcesk «t 1 Ceeapatianally expoaed to inorganic t Kosta, I. 1 Eg ot living In exposed area t Zcleako, T. I f Earaik. T. t Ittopsles. Yugoslavian, ages 19-75 I levstek. R. 1 ji \| Deraelj. R. 1 \| Eyrae. i.1. I IID1ISTBI11 mtVTIOB; OCCDPIHOIU \| 19?a 1 BltUDS; POPOtHIOf ZH050II; 1 coapacatlm stndi«a of I ST18SEST: incoiT; HRCTBI C1G1IIC \| Food and BavltoiMatal 1 CCIKrans; TOEOSUTI1; tDTOPSIIS; \| Cootaalaatiaa. I EIOOD; BB1II: 1CIDIBTS; LITIB; LtOMS: I Proceeiiings of a \| IOSCIXS; snm; TBTBOIO GIMPS \| Syiposim k«U 1« 1 I otaniaal, Finland, 1 1 lagist 27-31, HT3 1 1 1 1 72.0 mg/g frask wt I tatopsias, c«gil«c eaBstmrs of fia-h I Cappon, C.J. I ceataiaiaq >C.5 tpa total Bg 1 Saltk, J.c. i . i net t Canadian Indiana, aortkmst Ontario \| Journal of Analytical 1 1 Toilcologj 5:99-98 f fisus; FOOD cotTiBinnoi: t I lisreniit poiiinioi: POPDHTIOI i \| (IPOSm: 10 ML 1EEIS; USBll UllSi \| 1 SITES poitmoi: BSKUJI: BIBCOBT t I ciEiiic coRpcmDS: IEMT; IIBKIIS: i 1 IITIB; naCZBU; SPLBII; CUIDI; 1 1 10TOPSIBS 1 1 1 1 1 538 ng/g frank «t I Gccipatloinllr eipooea to Incrginic 1 Kosta, L. I Bg oc living in erpoa«d area 1 Zelenko, r. 1 1 a»ik, T. 1 litopsles, Tagoslariana, >g«a 19-75 I lerstek, 1. 1 Tr. 1 Berielj, I. 1 F Byrne, I.E. 1 HBDSTBIH EdLnHOI; OCCaPITIOlU F 197* I imiDS; POPOllTIOB RKSOBB; 1 coaparstiw stadias of 1 SUBCXBT: HBBCOBI: BBBCOBT OBUBtC 1 rood and ZBTiconaantal 1 cetpcuiDS; lososiiTH: IUTOPSIES: i coataalnation. I ciooo; ism; riciiTs; LITSB; IOTGS: i Pcocwsatags of a 1 BIfCIBS: SP1ZEI; THTBOIB 6IIIOS 1 Sraposiaa held in 1 1 otulani, Finland, 1 1 lagiat 27-31. 1973 « • 1 1 7.6 n«/g freak at 1 utopsy, ragalar conaaier of tlA ^ cappoa. C.J. 1 containing >0. 5 ppa total Hg \| Snith, J.c. 1 1 1981 I Ciaidlu ndiin, nortinest Ontario 1 Journal of analytical 1 1 Toxicology 5:90-9* I TISHIS: FOOD COITHIUTIOI; \| I utosTBiai. tavmot; POPTOIIIOI i I fieosmx; BUIIL HBIS; UEBII IBBIS; i i iiTm poLKnioi; BiROJsi; SIBCIBT i \| C5S11IC COIECOnS; BI1BT; KIEPBTS; 1 t 1ITCB: MICEBTl; SPLHI; C1I1D1: I I inOFSIIS 1 1 1 1 1 ng/g freak at 1 Cccapatloaally expoaei to inorganic 1 Koata, L. j Hg or liTinq la axpoaed area 1 Zeleako, T. I t Barnik. T. 1 latopaien, Tigoalaiiaas, ages 19-75 I leratak, R. 1 It 1 DcrielJ, 1. 1 1 Brno. l.l. I XIBOStBtll POIlUTIOl; OCCBtiTTOnU. \| 197« \| BltHIS; POPOLITI01 KPJSini!; 1 Comparative stadias of I S08SCTI; moral: IBBCVBT OBGHIC 1 Food and Environmental 1 ccipoaiDS; TIOOSUTII; IOTOISIBS: i contiaiaatlon. I I1QOO: BtUI: KIBRTS; tITIB: 1OTGS; \| proceedings of a \| IDStttS; SPttM: TBT80ID GL1B9S 1 Syaposiaa kali ia I I Otaaleai, FinlaiS, \| 1 lagut 27-31. 1973 1 1 00 tmtn fast) ------- i«rcacT<1»l, Mtlrl-* too It ci) «erc«TT(t»\|, awtkyl- f9 CI) S!«67-92-« C-B3-B.J M S1S.S3 1IS30I •253 Eidney 425* Liver •255 Liver •25« Ilacenta •257 Spleen inosm son! Tngeatioa laoaatlon laaalaUm Invention Ingeatioi llaUTICal BET BOD 8C n ac oc oc HJB8SS OF C1SIS 1 7 1 3 1 MKI •at applicable 10-28 ng/g freak «t lot applicable 15.6—28.0 ng/g fresk vt lot applicable mi 78.1 mg/g freaa it 18 »g/g frank vt 95.5 mg/g fr«sk vt 22.3 mg/g freah vt IOC. 5 mg/g freak vt eilEIiL IIFOtRlIIOI la-topsy, regalar canatier of flak coatalalaq >O.S cpn total Bg Canadian Indiana, nortkmat Ontario MS BBS; FOOD CORUIUTIOI; iiBvsrtitt vountioi; rornLanoi MPOSUt!: BOBIL atlas; tJBBll »E1S; IITEI potumot; mean; BBICOBT CEGMIC COB»Onos; BMBT; KIC1BIS; IITCT; TLUXRa: SH.E1": CHUIl; lOTOFSISS Cccnpatlonally expoaad to inorqanic tq or llTi««j In exposed ar«a latopsles, TaooBlavinns, aoea 19-75 Tt HDUSTBUt fCllDTIOl! OCCVFHIOIU HIlllOS; POfOItTIOI 0FOSDBI; SOBSEBT; BEBCVBI; 1EBCOEI 0161VIC CCtPOTIBS; TOGOStlTIl; ITTOPSKS: HOOD: saiti: EIBIBTS: LITEB; inss; "BECLIS; SPLEER; THIBOtt SHIDS Ktopsy, raqilar cognaec of flsk caitalninq >O.S tpn total tg Canadian Indian, northvent Ontario fl!B»S: FOOD conuinnoB: iiDOSTiiai FcunnoB: POPOHTIOI MPO50BB; KOIU, US1S: IBB 11 atElS; IIIH paiivrioi; niaisT: SCTCOII tsaiiic coBFcnos; HEIST: Kmsis: ITTEl; ?L1CIR1: SP1EM: CII1DI; 1BTOPSIE3 fletkyl predaalnnnt focn (56.9M in afaciaens lealdeats of hlgkly IndutrlallTed ax«a IISIES; FOOD COITl»I»TIOl; IIDOSTIIll FCLLVnOI; POFOL1TIOI tlPOSBBE: tdi»L 1BE1S: 08B1B IB 'IS; imn pounioi; nEBCOBi: BSBCuirr CSSIIIC COBPCBIDS; BB1BT; KIKETS; IITER; FUCIIM; SPLIEI; CU1D1; 1BTOI3I1S lotoptf. reanlar coaannar of fiat eeatainlng >O.S cpa total tg Caaadlan Indians, nortkveat Ontario IISBBS; FOCI CORHIMTIOI: IIDOSTBI1I FOLLOTtOB; POPBI.JII01 Eiioson: BOBIL »EIS: OIBII tsiis; IITEI POtllJTIOl: SEBCOSt: HEBcaBT CtSlIIC CO8FCOTOS; 1X1R; KIDIITS; IJTEPl mctRl: SFIZEB: C1UDI: 10TCISIES BEFEEiBCE Cappon, C.J. snitk. J.c. 1981 Joaraal of analytical lox oology -.90-98 Koata, I_ taTnlk.T. tCTBtex, H. Dernel^. B. Byrna, 1.1. 197 • Coaparatln 3 1 alias of Food and Environaental Contaa {nation. Proceed Ings of a Synposlaa held in Otanleai, Finland, lagwt 27-31. 1973 Cappoi, C.J. Saitk, J.c. 1981 Journal of analytical Toxicology 5:90-98 Cappoa, C.J. Saitk. J.C. 1981 Joaraal of analytical Toxicology 5:90-98 Cappon, C.J. Snitk, J.C. 1981 Joaraal of analytical Toxicology 5:90-98 \O ------- £ CD Benzene, 1,3.5-triaethyl- (» CT) C1-H12 •1 120.2. m -»».8 C. BP 1««.T C. TP 10 •• 89 at «7.« C 1ISS0B (258 Breatk «2S9 Breatk EMOSOSB ROOT] 1U1ITICU BETBOD 8C/BS GC-BS BOBBER OF CASES 8 54 (317 sa«pl«3) I1IGE lot detect«d-0.81 a«/hr Mot 9lT«a BE1I 0.12 ngyhr O.S2 ng/1 Gcowtcic 1 6»»1I IK01BITIOI Ccipoaid related to >orial Ktabollsi. lo otk«r tetalli qlrea Cryogenic »»ipllttq technlqa.. 8«althy aili tar T and ciTillaa •iploreea, o.s. air Force School of lerospaee «edicia«. ag«s 23-«7 ji. 3 siokers. EflXnsS; CBIOBIIUBI HTDSOC1BBOHSJ cnottiiB oieinc coipomms: CE1CROBNZIIIS; FIOOIIIE COBPOOIDS; CBI1T8; HCCBOLS; IET15; IDBITS taanr«a at 25 C a«d 7 SO IB Rg 32.CV occurrence to««r and upper ox-SlgBa lliita 0.327 »Dd 2.16 aa/1 Realtky, 18-35 yr old, nonsBokiaq, artaa blacks aid caacactans. Ckicaga. n. Biqillr controlled experimental conditions. flint; itccNts; IIIIBOIS; IDUITS; CBICBIUTfO BIDBOCtlBOIS: T011THE CBGIITC COSfCOIDS; HE11TB B1Z1ROS; IIBtHTIOB: IRaBOlISI: IET1EOLITES: EC?OHTTO» JUOSOIE; 3SB»B IBEaS BEfEBEBCI ConUe, J.P. Caip, B.J. Mick, B.E. 197S irefciwea of EnTironaeotal Bealth 30 (2): 290-25 Krotasiuwki, B.K. Braaeav. e.R. O'Heill, B.J. 1»7» Journal of analytical Toxicolovr 3:225-23 N) M O Ictkam 7»-82-8 C-H* BI 16.05, B? -182.6 C, BP -161.5 C, TP «00 » Sg at -168.8 C IISSOB •260 Breath ElfOSDB! KODTI 1 1B1LTTIC1I RETBOD ec/«s BOBBIB or cisEs 43 SMGE 0-32 PPI R»l S.1 ppa 1 I GCBIIll IIPOBBKIOI Corrected for lerel in inkalefl air Eealtky adults SIBBEB; 1 DOITS; HE»SBBE9EII IETRODS; IIIR1BOL EEYEREVCE Jansson, B.O. larsson, B. T. 1»69 Joarnal of Laboratory and Clinical Bet hods 7«(6):>61-966 ------- Betkan, dlcUoro- 75-09-2 C-BJ-C12 •1 »».»«, BP -95.1 C, BP 39.75 C. TP 3(0 «• Bq at 22 C TISSUE «2C1 Breath RPOSOtl SOOTE ivaiRicii BBTHOD SC/HS BOnBES or cisss 8 MKC lot tetected-30.0 og/»r BM.B 55.0 ag/kr SEBtML IlTOIBmOl IrplOYM>> 0.3. iir POTOB School of Icrospac B«aiciae, a««s 23-»7 jr. 3 xaokaxs. intnR; cBioiniTit nnocuiBOis: cnoim OBEIKC COBPOOWS; CBiowjEEiitiis: nnoBin coiMons; iiena: ncflfiois; THIS; irons XXriBBlCE CODkl«, J.P. Caapv B. 3. Mick. 3.1. iris lrckiT«s of EMironB»nt»l Health 30 (U -.290-295 4icUoro«itlvoro- TS-71-S C-C12-P2 . B< 120.92, BP -15B C. SP -29 C, TF S at* at t6.1 C TISSJS «262 I2C3 tile •26» Blood • 265 Hood MPOSBR BOOH \| 1 Inhalation Inhalation Inhalation inhalation amiTIClt BETBOD ac oc BC taiioaetcy BtriBZI OP CISSS 1 1 t 1 1HGB lot applicable Bot applicable lot applicable 0.5-0 ng/al («BW sail 13 »g/g vet «t 13 ng/g «et t _ 1.2 og/g vet «t lot applicable PIGB) Gill HI IBrOlBinOl Ceeatae. litopsy sanple. Death 1.S kt after sniffing cooking spear. Bale, age 13 jr. kt 62.5 in. 11BOPSIBS: IDTPOSB IISS01; BILB; EtCOD; 9B1II; HEIST; IXDIBTS: LITIB; miss; anscus; CHIOKHTEP BTtBOClBSOIS; P1IOIIBB COBPOOBBS latops. leatk 1.5 fcr after sniffing cooking spray. Bale, age 13 yr, kt 62.5 In. itrtopsiES; itiposs tissBi; BUS: EIOCD; BB1IB; B!»BT; KIDIITS: LITEB; lUfCS; in SC1K: CBLOBIBaTBD ItBSOCHSOIS; PtOOIIBI COBPOOTDS Beart blood, lutops) sanple. Beath 1.! fcr after, cooking spray. Bale, age 13 yr. kt (2.5 In. i BIOPSIES; mpos: nssoE; BUB; E100I; BttlB; BXUT; KID IBIS; 1ITEB: mass; aoscLis; CBLOBIHTBD ETDBOC11BCIS; TIDOBIIS COItOOIDS It ani 5* ain after »S.» ag/aln, 16,75 ein. Initial neastirenent, .05 og/al at 0 tine. Bstlaated froa graph. HOOD; PLBCBIIE COBfOIIIOS; it BITS; BiismaBn BITBODS i Staadefer, J.c. 1975 Journal of Porensic Sciences 20(3) :S8-551 Staadefer, J.C. 1975 Journal of Forensic Sciences 20 (3) : 58-551 Staadefer, J.c. 1975 Journal of Forensic Sciences 20 (3) :S»8-551 idle, J. Blake, D.A. mrgnar. C. B. 1975 Journal of Clinical Pkaraacologr 15:760-770 N> K) ------- gathane, Aicaloroaiflaoro- 75-71-t C-C12-M •I 120.92, Ii -15S C, BP -2* C. f» 5 ata at 1C. 1 C (COITIIOED) tissos •2CC Braia «267 Boart «26« Eiaaey •269 Lime «270 laao »271 Basel* EIPOSBIS BOB inkalation Isaalatioa Inhalation Inhalation ahalation halation aULRICaL RBTHOD ec sc ec ec ec EBB BBS or cisES 1 1 1 1 BaiGE lot applicable lot applicable lot applicable lot applicable at applicable ot applicable BE»B i 6BMUL iBFOBRinoi i BBFBBBBCB i i 3.5 ag/g vet vt \| latopsy. Death 1.5 kc after saiffiag I Staaoafer. J.C. 1 eeeklaq spray. \| 175 1 - \| Joaraal of Forensic 1 Bale, age 13 yr. kt 62.5 la. I Sciences 20 (3) sSa.8-551 1 1 \| IHTOPSIES; 1CIPOSE TISSUE; BUZ; \| 1 HOOD; BSIIl; BEaBT; KIDISTS; LITBB: \| 1 igies: insciis: cnoiiuTsu i \| BTDBOCI8BOIS; TIOOBIK CORtOOIDS I 1 1 1 1 1(0 ag/a rat ot I Mtop«T. Death 1.S he after sa iff ing I Staadefer, J.C. 1 cockiiq spray. I 1975 1 1 Jouraal of Foreasic 1 Bale, age 13 yr. at «2.5 ia. I Scieaces 20 J3) :5«8-551 • 1 1 1 IOTOTSIS5: IBIPOSE TISSOI; BUB; I 1 tXOOD; gsillj BHST; KI01ETS; 1ITSS; \| 1 miss; nosciis: CILOSIHTBD i 1 iToiocmcis; rinosui COBPOOWDS i i i i i S.« 09/9 vet «t I latopsy. . Death 1.5 hr after sniffing \| Staatefer, J.C. 1 cookli ------- Mtkeie, ilcHoiotlmaro- c-s-cu-r II 103, »P -US C. It «.9 C. TP 2 at! «t 28. « C 1ISSOE •272 inttk EirosoiE BOVTE - 1U1TTIC1L BZT80D OC/HS - •01MB or cisss i MICE Bot OeteCted-0.062 ng/kr SB1I 0.025 aj/kr GEIZUL moiBaTxoi Previous exposare to coipoavd. Bo cthar ietaili gt«tt Cryogenic xanpling tecknigee. ttaltkr illitMT ni clilliai aneloyees, O.S. lir roree School of aerospace Bedicine. ages 23-47 re. 3 (Mints. ««ii!3: cBioniaiBD nmociBBOBS; cnomi oBCinc COBPOOBBS; CBlCBOBntZBK; nOOIIBE COBMOBDS; fBUTB; 11CCBOIS: THIS; 1 DOLTS BZiniBCI COBlEle. J.P. Cup, E.O. »«lck, B.Z. 1975 »rchl>» of EBTiroiMita.1 B«alth 3U(2):290-295 B«tbM, dicHotomltio- 7119-89-3 C-B-C12-B-02 B1 129.93, BP 107 C tissn •273 Btutk BIIOSIIBE Ksm llltTTICtl \| BBTBCD \| 1 SC-B3 IBS BIS \| 01 cists i » <3»7 •upl«s) - B1KI \| Bot ?lY«a BB1B \| 1 1 I 6».1 ug/l Saoietric _ CtllllL 1BPOBHTIOB I«»mcd at 25 C «»a 7CO mm eg 2.St occncc«iic* Io«• Bg. -23.0 C at 100 ma Bg. -32.3 C at SO ai Bg. -39.0 C at «0 n Bg. -19.7 C at 20 la Rg, -59.0 C at 10 n Bg. -«7.6 C at 5 •• flg. 8«.3 C at 1.0 u Bg 1ISSVB 27« »4ipo»« •275 all IXIOSBIE Bonn Inkalatlon lakalation kBllTIlCll BBTBOg ac ac BOBBS5 OF CISSS 1 1 BIB6B Bot applicable Sot applicable (BUT SE1I 1.7 «g/g net lit - 3. 3 ug/g vet vt tKtt GEBttal IBrOIBlTIOl CaaBtai. autops> aaapl«. gcatt 1.5 kx aft«r sniffing cooking spiay. Bal«, «g« 13 71, at 62.5 la. •Dtcpsies: IDIPOSE tissoj: BILE: HOCO; B11II; BEJtT; KI9BZTS; I.ITB1; LOISS; 4VSCIES; CBLOEIBaTEO HDtocmcis; rmoiiii COBPODBSS latopsT saapl. Doatk 1.5 Ir after :«lffltg cooking sptay. Bale, age 13 rr, kt 62.5 in. 11IOPSIES; ItlPOSE TXSSOE: BILE; MOOD; BI1IB: BEAK; KIBBEIS; 1ITIB; ICISS; BOSC1IS; CfrtOSHlTID BTBtOCaSBOBS: TLDOBItE COBIOOI95 BE7EBEBCE Stantefer, I.e. 197-i Joornal of Tocensic Sciences 20 \|3) sSM-551 Standefer. J.c. 1975 Jooraal of rot en sic sciences 20(3) :S8-551 ------- Ettaane, trlcUoroflaoro- 7«-69-a C-C13-» C-C13-» n 137.38. BP -111 C, BP 23.7 C at 760 •• Hg, «.l C at »00 ll Bg. -9.1 C at 200 •• ig. -2'3.0 C at 100 •• Bg. -32.3 C at «0 •• Bg, -39.0 C at 0 u Bg. -M.7 C at 20 aa Bg. -59.0 C at 10 aa Bg. -67.6 C at S aa Bg, 8.3 C at 1.0 aa Hg (COIIIBIEO) TISSUE a27« Mood •277 Blood •278 Era! a J 1 «279 1 Breath EIPOSUBS BOOT lakalation Inhalation Inhalation 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 120 Beart •211 I Ildney Inhalation n halation lEUYXICIt BETBOD OC Badioaetry ec SC/HS 6C X BHBBEX or CASES i 2 1 • HBGS Bot applicable 0.8-.05 ag/il Bot applicable Bot detected-O.Otl ag/kr i Bot applicable lot applicable BE1E 0.6 ag/g vet vt Bot applicable 0.5 ag/g vet vt 0.011 ag/hr GZBIS11 IBFOBBITICB 1 BEFEBZBCB 1 1 1 Beart blood, latopay saaple. Death I standefer, J.C. 1.5 hr after sniffing cooking spray. 1 1975 I Joarnal of forensic Bale, age 13 yr. kt 62.5 in. I Sciences 20 (3) :5»8-551 1 ROTOPSISS; IMPOSE TISSUE; BUB; \| ElOOD; BB1IB; BE1BT; KIDBBTS; I. IT SB; I tU»GS; BDSCIES; CR10BIMTED \| BIOIOCtBBOBS; FIOOBIBS COBPOOBDS I 1 0.25 and 1.5 hr after 35.6 ag/lin, I Idir. J. 13.75 nin. Initial neasareaent, .05 I Blake, 0.1. og/nl at 0 tlae. Zstiaated froa I Bergner, 6.B. gtaph. \| 1975 1 Jonraal of Clinical Sabjeets weighing 63.0 and 95.0 kg I Pharaacology 15:760-770 EIOCD; TIDOBIBE COHPOIBOS; 10DIIS: \| BIlSmnSBT BRBODS 1 1 latopsy saaple. Death 1.5 hr after I Standefer, J.C. miffing cooking spray. \| 1975 1 Joarnal of Forensic Bale, age 13 yr. ht 62.5 in. I Sciences 20 (3) :5«8-551 IOTOPSIES; 1BCTOSE TISSUE; BILE; I 6IOOD: BS1IB; BEUT; KIDBETS; LITBS; I miss; nnscits; CHLOHEITED i BTEBOC1BBOBS; FLDOB1BB COBPOOBDS I Previous exposure to eoapoand. Bo I Conkle, J.P. ether detail! given \| Caap, B.J. Cryogenic saapling technlgoe. \| Belch. B.I. \| 1975 ealtky ailltary and civilian \| Archives of aployees, D.s. Jir Force School of 1 Environaental Health erospace ncdiclne, ages 23-07 yr. 3 \| 30(2) : 290-295 aokers. i 1 j 1 IIBZEHS: CBICBIB1TEB BTDBOC1BBOBS; \| 1 C8LORIH5 OBG1BT.C COXPOOBDS; I 1 CBICBOIEBZIBIS: FLOOBIIE COBPOOBDS; 1 1 MEMS; tICOBOlS; THUS; 1 DOITS \| 1 1 »9 ag/g vet \| litopsy saaple. Deatk 1.5 hr after I Staadefer, J.C. 1 aniffiag eookiag spray. j 1975 1 I Joarnal of Forensic I Bale, age 13 yr, ht 62.5 ia. I Sciences 20(3) : 58-551 1 1 1 IBTOPSIES; 1BIPOSS TISSUE: BILE: \| 1 E1COD; BB1IB; BUST; KXDBETS; LXT3S; I 1 iftias; lascus: cmoEimiED i 1 BYBTCCISBOBS; FLOOSIE! COBCOOBOS I 1.1 ag/g vet vt I latopsy saaple. Deatk 1.5 hr after 1 Staadefer. J.C. 1 sniffing eookiag spray. \| 1975 1 1 Joarnal of Forensic 1 Bale, age 13 yr, ht 62.5 ia. f Sciences 20 (3) :5as-5S1 1 1 I IVTCTSIBS: IIIPOSI TISSUE; Bill; 1 1 IICCD; BBiiB: asm; IIDIEIS: LITXB; i \| 11B6S; 10SCIZS; CBLOHEHED \| 1 BTtBOCIBBOBS; FtOOBIBB COBPOUEDS \| 1 1 (BUT PIG I) ------- (etk»e, trickloroflaoro- c-ew-i ! II7'31! "JJ'J S' ?«23-7.c hTf* ™ M'.-9 c • °° at iw •• Ha -«7.o c at 5 •• H0p Ba.j C at 10 M 09 C at 200 aa Bg, -23.0 C at 100 • eg. -32.3 c at 60 aa Bo;. -3».o C at «0 aa Bg. -»9.7 c at 20 aa Eg, -59.9 c (COHXB9ZD) I13SDJ •282 liTT •2«3 HM •2M •i«cle Einsnit mm XaaaLatioa I«k»lation iBkalatlon lUlRICtl nnoD ec oc sc I0BB1B or cisis i i i IM6S lot applicable lot applicable lot applicable am 2.9 »g/9 nt it 3S «g/j wt »t 0. S og/g nt nt eiinii nmutxoi • IstoptT s&ipl«. B«ath 1.5 ar attar >al((iiq cockim spray. B«l«, aq« 13 TT, at «2.5 la. uncpsiis; iBirosi nssos: BH.Z; noctj BBHI; nm; KIBRTS; IITSB; miss: loscizs: CHIOIIHTII (iriociiaois; riooim COB pom DS Igtopar saaplo. Itaatk 1.5 kc attar •ilffiaq cooking spray- «al«, aq 13 rr. kt 62.5 in. inopsus; IBIPOSI nssoii BUS; ttOOBt nut; RE»«; ttgrttS; IITEB; tnies; 10 sens: cnoBiittn IIB10C1BB01S; TUOKK COBPOimOS lliopaoaa. iDtopsr Mipla. Death 1.5 kt aCt«i miltiBq cookiag >pcaT* lal«, ago 13 rr. at 62.5 in. inopsus; (iiFOSi nssoii BIU; noco; BtiiB: Bum; KIBIITS; LITBB; linos: ASCIIS; CHLOSIHTII) StDtOCIBBOIS; riBOSIU COBPOIWDS Btrnmct sta>af«. i.e. 1»7S . Journal of rorauie Sciences 20 (3) :S«S-551 st»oa«t«, J.C. 1»75 Joarul of Porenslc Sci«K«« 20(3) :5««-5S1 st»»a«t«r, j.c. 1975 Joutnal of Forensic Sciences 20(3):5I>I-551 M KJ Ul soaie add (8 CI) ccoaie «cia, MthTl- (9 CI) :t-se-3 -H5-1S-O3 B 139.96. BE Ul C (585 TliM EIEOSOB; BOOTB IHILTIICU BETBOD ROB BIB or cisss a) 9 b) ia IllttJ a) tat qlm b) lot gi?«n BS1B - a) 1.7 ag/g ccaatijtina b\| 5.2 u ------- Retkanol C-BB-0 •t 32.0, IP -»?.§ C, BP «».7 C IISSUI «28« tieatfc «2«7 Sreatk •28. Breatk ixposin* ton iHinxui BBTBOD er/BS oc/as ec-as inaan or CUES , 5» (387 saaplea) laKX 0.27-3.39 ppa lot d«tect«d-2C.O of/kc >Ot flT«B Bill 1.0S ppa 3.7 «j/»r 0.59 ag/1 SeoHtcic GsisiiL laroiaitioi Corrected for level la inhaled air Eealthr adults sum: icons; BMSTntBssiT BSTEODS; IITB1IOL Ceitoma related to aoraal •etabolia. »o otler details ging Cryo^eaic saapliaf ^ecnnla^tt. Bealthr ailitary and elviliaa aaplorees. U.S. air Force School of texospace Beflcin, aqes 23-47 TT. 3 stokers. Eiitms: caiointTEO BTDIOCISBOXS; CBIOSHI oaeiaic COHPOOIDS; CEietoBinziijs: nvom: coapouwss: SMITH; itcceois: TBUS; IDOITS ttaaared at 25 C atd 760 aa Kg 3.61 occurrence Io«er BBS nfper one-Si gaa liaits 0.1S1 and 1.99 B9/1 a«altkr. 18-35 jt oil, QOHBackia<7. ortaa blacks a»d Caucasians. Ckicsgo, It. Biqidlr controlled eipcrlaaatal coalitioaa. IlflTI; 11CCBOLS; IILIWOIS; 1001TS; CBtCSIHIID BTDBOCIBBOIS: »OHTH! ciGinc coBconos; BIUTI BIIHDS: IIB1UTIOI; BIT1MLISI: BETIEOLITZS; topniTioi iiposraa; USBJI IEEIS BIWSEICI Janaaoa. B.o. IBTSSOI. B.T. 19«9 Joacaal of laboratory and Clinical Retools 74(K):9«1-9«6 Coakle, J.P. Caapr S.J. Velch, B.E. 1975 ftrckives of EBTiroBMBtal Healtk 30 (2); 20-295 KrotoaziBaki. B. K. Braaeag, G.I. O'leill, B.J. 1979 Journal of iBaljtical Toxicologr 3:225-23 CT- ------- tUmllit* t» ct) id. Martin ( CD c:-»2-o C2-M-S2 §1 91.2, It 109.7 C, If 26.« II B« It 25 C (conitmq I1SSBI •290 Bmtk IIMSWI MHI llllttlClt •BTRQD SC-BJ OF C1SIS 54 (37 aaipl*) I»GB lot 9lT«a BMl 1.9 mo,/l Ceoaetric 6EBZB1I IBTOBBaTIOB C«m4 at 25 C aal 7(0 •• tg 33. 1* occarreace leMr aal upper oa«-Sloaa Ualts C.M7 aal 7.M mg/1 lealtkv. It- 35 TC oli. muokiag, ortai bltcki aid cancailua. cticaqo, II. ilqidly controlled tiperliettal eoailtioac. Him: HCCHOIS! tUIMUt UHUS; CitOIIHTZt mtOCIIBOISi TOHTHE ClCinC COBPCBIPS; BMIT8 IKllDS; HBlIAtlOtt BITIBOIISI; B««O11TSS: wjniitioi zttoson: niui mis nnmcB Itotonnaii, g.i. Bcneai. «.B. O'leltl. B.J. 1979 Jonraal of aulytical Tozleolo«f 3:225-23* «thil cdlflte (9 ci) «thu«, tUcbl- (« CI\| I-U-3 J-tt-S 1 (2.11, n -13.2 C. IP 37.5-31 C TXSSVt • 291 Bnatk •292 Bieatk EXtosni Konti lUtTTICll -IRBOI OC/HS oc-as IUBBM or cases t S« (3(7 •aiplu) MICE - lot fletecteS-53.0 aq/nr lot ^iTen «.. 17.6 ij/hr Seowtrlc SlltUt IR01BKIOI - Coepoeil related to lonal aatabollai. la other details qln CrTOTealc laipliaq teck&l^ae. lealth? illttatr ui ciTili« •iploraM, n.s. air Face* School of »ero«j>ac« Mdlei*. aoejs 23-7 It. 3 disnts: cBioBiiiTjo BTDBOCWIOIS; cnotin oicinc COBPODIDSI ciiotoimms; nnoiriE coBfonns; E1I1T9: I1CCB01S; TZI1S; 1EB11S Pea«mred at 25 C ai4 7CO •• Bg M.«% ocemnaca lover nd «ipac ow-Sloai Halt* 0.2 aid 2.30 aa/1 Bcaltkr. 16-35 TC old. noBHokiaa. •tin bltclii aid eaaeasla. Chicago, II. BigldlT coitrolled •iperiwatal conUtioia. flZlTB; IICOMIS; IIUIOIS: IOOIIS; cnoiiiktie iniociBBaiSi Toitins ciemc coBpcutDS; BIU.TB IMIBIS: uiiUTiai: RTiBoiisi: BEIIWLITH: EQIOUTIOB ZmsgiE; BJBal 11IM MIBMBCI coikla). J.P. caip, B.J. Mich. B.I. 1975 lrekie* of EUTlTouatal Health 30 \|2): 290-295 Krotoatimeltl, B.K. Bruaaa, e. R. c'lelll, B.J. 1979 Joarial of analTtieal Toilcologj 3:225-23* NJ NJ ------- ItV 95.94, If 2622 C, BP «25 C (appro] , TP 1 •• Hg at 3300 C, 10 •• Eg at 3770 C 1ISSDI •293 Blood, (hole »2»4 Siir IIPOSOEJ BOOT «295 Kidney 1 1 1 1 1IUTTICU RETBCD It IUBBSB or ciSBS w IMBB 0.50-15.73 ng/100 al ) a) 0.072-0.67 tg/g ) 9 b) 0.00-0. «1 ua/g c) 10 c) 0.069-0.24 ng/g let vt BEtB i GEiim iirtnunoi 1 •ot given 1 lange of aeau. snltiple aaaplea fro 1 9 collection cites in the U.S. 1 1 SIIHTUS: aOIIBBUTTB: TUIDIBS: 1 HOOD; SEX: SOOTB BlKOTi: IE TOBIt: 1 iiCBlie: mKMi: OHIO; KISSISSIPPI: 1 1II1S; SOBTB D1ICOT1; I1SHII6TOH; 1 C1LIPOSIII: lEIZOH; 1191111; f lOVISTUl; IBM ISIS; FWBIDI; 1 TIB SOrl; TB1CI EIEIEITS t i Bevlev. 24 repreaeatatlve 1 pte-analysis treatunts arc 1 tabelated. The feesibiltty of a 1 holistic, no-wash policy for hair 1 analysis is oetliaed and supported. 1 ItTIEIi T1CI EtMHTS; HUE; I itsnuij; BiisusBsn BFTBODS; I riTus; PFOIHIS: CORPIUIITE 1 ITllniTIOIS: 1HTBII09; lITIIOiy; 1 IISZBIC; B1B1US; BBOK1T: ClHIItlH: 1 CI1CI0B; CBIOBIRE; CEBOBIDB; C011LT; 1 CCFPEB: GII1HI": SEtBHTDB; GOLD: 1 10DIII; ISOI; UtTHiIld; Llir; 1 (IGIESTVar BlKalESB; BttCOBI: 1 iciTEDinB: IICKH; psospuoins: 1 POIISSI5B: BOBIDI0B; SELEIIB1: I siivxa; SIITEB: SODIOH; STBCITIOI; 1 SDirjB; TII; TITHIDB; TDIGSTEI; I inc; IIBCOIOB 1 1 a) 0.22 ng/g F a) Controls b) 0. 19 ng/g I b) vortor grcup I I 0. 10 ng/g I c) loiter grenp II let ft I edians I teceased refinery and seelter 1 1 netkers, ages 55-76 yr. exposed to 1 1 hiavy aetals 1-3 decades, liee f f netwen retirement and death 0-1.5 yr 1 1 it gro«p I a«d 2-19 yr, group II. 1 controls, ages 43-72 yr, vho lived 50 1 ki frei the factory- sneden. 1 SI!B!»: C1D1TEIS; IIDIXTS; IITZR; 1 ICISS: C01FIUTIVE ETaHUIIOBS; 1 IIDOSTtlll BTSIEK: BBISDJBBOTT 1 9ITBODS: IITIBOIT: IBS MIC; C1DIHFS: I CISIOB: cHBomr»f COBJLT: COFPBI; t GOir; HOI; I1RB1IOH; LE»: 1 eiIGI«ESt: BKCOBT; HOLTBIIaim; 1 CBOSPBOBOS; BDBIDTDR; SC1IDIOB: 1 sniBin: SIITEB; TII; TBIGSTH: 1 ZIIC: BMITB B1Z11DS; IKDOSTBH1 1 PURS: SRIlTtBS: TEllmiOR BIHBEJCI illa«»j, I. H. Xnbota, J. Loses, P. Roth, B. 1968 Archives of Znvirouental Health 1S:342-3«t Chittleborongh, G. 1980 Science ot the Total EnTironnent 14:53-75 Brnae, 9. lordberg, G. Hester, P.O. 1930 Science of the Total Environment 16:13-35 •MM PIS I) .-- .. 00 ------- Boljbiftam 7«39-9»-7 Be ttl 95.9«, SI 2622 C, Bt 41J5 C (approi), TF 1 n Bg it 3300 C, 10 u fl» »t 3770 C 1IS5IE 4296 lifer 4297 Into. EltOSBBE BOOK aEiimcu BsTHOD U BBBBSB OF CISIS •J « » 9 c\| 10 at B W 9 c) 10 E1KE a) 0.34-1,24 ag/«; b) 0.21-1. C9 ag/g c) 0.22-1.33 ag/g Vet vt a) 0.011-0.27 ng/g b) 0.014-0.15 ag/g c) 0.020-0.12 «g/g Bet wt BBAB \| GEEESal IBWBBHIOB J a) 0.5 og/j \| a) Controls b) 0.65 aj/g j b) Vorker group I c) 0.4* eg/g \| c) Borlnr groap n Vet «t I Sediaas j E«c«as«d refltery aid iMltet 1 workers, ages 55-76 yr, exposed to j leavy aetals 1-3 decades. Ties I tetween retireseat and leata 0-1.5 yr 1 la group I and 2-19 yr, groap II. I Controls, ages 43-72 yr. HBO ll«ed SO I ka fros tbe factory. Swedes. 1 1 SBECEV; CIDIfEBS; KIBBBTS; LITEB; I 1VICS; COBPlBaTITB CTIIDITIOBS; \| IBtOSTEIal BI6IEBB; BIISOBIBCTT 1 BiTWBS: iniBOBi: wsnic; CIDBIDB; \| CESIBB: CBBOB3HB: COBaLI: COPPEB; I SQID-. IKOB: laBTBlBBB; 1I»I; \| BIB6HSSE; BEECDB1: BOL13SEIOS; \| SELZEIOS: SIITEB; TIB; TOIGSTEI; I IIBC; BE111B SlIltDS; IBSBSTUkl \| PI1BTS; SBEltltS; TBlLDBIOa a) 0.030 og/g \ a) Controls b) 0.027 ag/g I b) Barker groap I c) 0.053 ag/g \| c) Barker grcap II Bet «t \| lediaas \| Ceoeasei refinery aid snalter \| Markers, ages 55-76 yr. exposed to I keary setals 1-3 decades, fine \| tit Men retirement and deatb 0-1.5 yr 1 IP groap I ail 2-1* yr. qroap II. I Coatrols, ages »3-72 yr, >bo liied 50 1 kn fro* tbe factory. Sneden. 1 \| SIEBEB; CaOlfBISi HIBI1IS; tITEl; \| IUI5S: COBPUITITS ITllUWIOBS: \| IBCBSnill BTGIEBE: BEISHBEBEBT \| SITBODS; tBTlBOBT; USIBIC; CUBTVB: \| CISTOI; CBBOaXBB; COBILT: COPPEB; I SQLC; ISOB: il«TBi»OB; ISaC; \| BlBGtBISE: BE8COBT] B01TBDEBOB; 1 traspBOBus; svaioiai; scaioins; I SltElini; SHIEB; Til: TOBSSTEB: 1 IIBC; BEalTB BailSDS; XBDOSlBIal \| PIlaTS; SBE1TEBS: TEllVBIOB UFIIEBCS BEtt&a, D. Bordberg, G. vaster, P.O. 1980 Science of the Total EcTlroBicnt 16:13-35 Bm&e. D. lorjberg, s. •eater, P.O. 1980 Science of tae Total EiTtronneat 16:13-35 KJ NJ VO Bapnthalene 91-20-3 C10-B8 «I 128.16, BE 80.1 C. B? 217.9 C. TP 1 ae Hg at 52.6 C IISSttE 4298 treat* BirOSBBB BOOTE - imnicii BET BOD «C/BS BBBBES OF C1SBS B B11GE Bot detect«d-2.» og/kr (tin 8EAB 0.5 »j/hr • PISE) GEIE81L tlPOBHTIOB Ftflilots exposure to coipound. Bo etner details qlTen Cryoqeolc saapllat tecaniqae. tcalthy nllltary and ciTiliai eaployees, U.S. air Tocctt Scbool of lerospaee Bedlclse, ages 23-47 yr. 3 linkers. EIBZEBtS; CBIOBIHTfC BT9IOC1BBOBS ; CE10H»! OBG1BIC COBPOtnilS; CBIOBOIEIZEIES: FIOOTHS COBFOVBOS; EII1TB; atCCBOLS; TE»S; ICO ITS BSFEBEVCX _ .. _ conkle, J.P. Caap, t.3. velch, B.E. 1975 lech ires of EKTironaental Bealth 30 <2J! 290-295 ------- Etpkthalanc SI-20-3 C1C-H «V 12.1C. IS 80.1 C, BP 217.9 C, TP 1 •• Hq at 52.6 C (COBTIBDED) TISSUE «2»9 Snatk nPOSTOE HOOTI IBIinXCIL BBTBOD 60-a s EVBBBB OF cms 54 f3»7 aaaplcs] EtIGS lot alra I I «u 9.772 as/1 Seoaetrlc 1 1 6EEZB1L IBTOBBITIOE ••••ami at 25 C ud 760 n Bg 98.9V occnTraaca) Io»r and apper OBB-slgaa Halts 0.335 and 1.T« ng/1 B«altkTr 11-35 JT tit, aoaaaoktog. •tin blacks aad caneaaians. Cklcago, II. tiglllr controlled «rla«atal coaditiogs. tltlTR: UCOBD1S; IIIHOIS; 1DO1TS; ceiotniTio nomciiBois: IOHTHS CI6IIIC COBFCOnSi BE11TH BtZtBCS; IHIlIlTtOI; tETlBOlISB; BBTIBOLITSS; PCP011TTOI IIPOSOBE; OMH 1BE1S 1E7EIIICZ KcotonyBaki, B. K. Bcnncaa. 6.1. O'lWlll. B.I. H7» Joaraal of iBalytical Tozioologr 3:225-2M 1 I lapattal«ii«, dlivtkyl- mo-ae-a cii-Riz >• 156.23, « T.CC C. BP 2«8 C IISSUB 300 Bnatk I BXPOS0U lOHTB IBU.TTIC1I HRIOD SOBS 1 •OBBEB or cisis 54 <3tT saaiplas) BM6B lot giren BB1B 0. 079 og/1 ^eoaetric GE1II1L IITOtllTIOB E«atc«4 at 25 C aid 7(0 la Bj 36.2V occncMBce lowac aad acpar one-Slgaa Halts 0.029 11 a 0.22 19/1 Bcaltk;, 18-35 re old. aonsaoklag. actan blaclES aad caacasiaas. Chicago, n. Bigldlr cont rolled expeclaeatal coadltloas. EBtHB: 1ICCBOLS; IILIIOIS; IOILTS; CBIOBMITCI STtHOClBBOIS; TOHTI1! CIG1BIC COBPCDIOS: HB1LTB BlUfES; IlaillTIQI; BETIBOUSB; BBMBOIITSSi f ICPWHTIOI HPOS9K: IFUIB 1EEIS BBPIIETCE Kcotostpuklt B.K. Broaeai. S. B. O'leUl. I.J. 1979 Joaraal of analytical Twlcologr 3:225-234 - 1 1 Ni UJ o Bagataalaac. antkrl- 1321-9-* C11-110 » 12. 8P -22 C. BP 2M.C C nssiB •Ml Bc«atk 1 EIPOS»E BOBTE IU1IIIC1L BBTBOB GC/BS 1 BOBBES or cisss 8 iUGB Pot d«t«ct«4-2.3 ag/hr (•in BEaB 1 eiltllL IlfOtBlTIOl 1 0.3 ag/kr 1 toapona frca aakaon origin. Bo 1 ether data lie glT«n 1 Crroavale aaapllaa taclnlqae. \| 1 taaltkr allltarv aad clTlllaa 1 aplOT«as, U.S. lie Torce School of 1 l«raspacc B«Jlci««, ages 23-47 jr. 3 I >aok«ts. I minis: CBIOITB»EO BIDIOCIBBOIS: I cnoiiis oieinc COBMOIDS: 1 cnotoBEizziis: TUJOHIE COBPOOIDS; 1 I1IMB; alCCWLS; THIS; 1C01TS 1 VfcBC) BEfEIEBCI ceakla. J.p. Caap, B.J. Mlei. B.E. 1975 IrcklTcs of EaTlroaaeatal HeaUk 30 (2J; 290-295 1 1 ------- fapataalene, MtkTl- I3J«-»«-» C11-114 It t«2, H» -22 C. IP 2M.6 C (CORIiniO) txssvi »302 Btwtk IHOSOB BOOT1 alalTTXCU HBT8O9 0C-IS miBR OF CISXS 5* (317 •Baplas) BITCI lot : ncoBois; IU.HOIS; UHLTS; CB10BIHTED BTDBOC1HBOIS; TOUTILZ cteinc COIICDIDS: nuia BIIIBCS; 11BH»TIOI: ERIBOIISli BBIJEOimS; FOftlUTIOt llfOSBIB: HHB1I 1B11S txntxtcs Krotoszjuki, g.K. Brueav, G.I. 0'eUl, B.J. 1»T» Jotimal ot kntlftlcal loilcolo^T 3:225-23 llelnl 1«0-02-0 II Itl 5.71. If 1«S5 C. BP 231 C, re 10 •• ig at 2090 C, 100 mm Sj at 23TO C Tissue i nposmi SOVIE i 1303 (loot. pl««a • 30» tlood. •305 Blood. pls» XtbaUttai iuimcit IBTBOD US us IOBBEB \| OF CISBS «} 1 b) 1 6 1U6E a) 3.0-4.0 «g/l b) 2.5-9.5 as« caoc«r in practical tipomc* cltMtlois. the a««4 {or dos« rfl«tratiOB i capitalized. ICIIkT; CIBCHOBIS; BLOOD rllSll; DIXIE: tiBasxsxu. neitn-. nrm: cnomi; a MILS; ncxn,; citciKGti; IlDISTtlll UMSFHXEES: IIBDSTIIES: cccopinoin >»»DS: IBOPHSBS at Barker axpoed to last of Imolubla 11 coapouls. Blniial dlirail variatios b) lorkat eipoMd to a«to«clt of tclmbl (i silt, eradnal rise aa 4ay pro^ccsKl Sellers i» roastlag-im-altiag SB a electrolTttc tooactceats In lornr. •mis: iicuH: •OBI«; iicflsriiu, ITBOSP9BBBS; OCCOPiTIOHl BMIEOS; neon msii: mitt a) Erot«ln-pMcifit«tion aaple preparation t) acid-digeatioa saaple preparation c) ProtelB-pnclpltatloa LO ------- lickel 1MO-02-0 li lt» 58.71, Ht 1«5S c. BP 2637 c, TF 10 » Bg at 2090 C, 100 » Bg at 2370 C (COITIHOED) KSSOS • 306 Blood, serna •307 float, •hole •308 ireata 4309 Bltaeaii • 310 nic EIPOSIU son Ingestion lagestion Xakalation 1 MI men. IETHOD IIS us PIK TOBBSB or c»szs i * i MIGI i) 0.3-3.* ag/1 b) I.S-105.0 aa/1 a) 0.t-«.S ug/1 b) Z. 9-79.0 «g/l lot gireg aiti i GEEZBII IBPOBBMIOB 1 >) 1.60 * or - 0.93 I •) Baaeline »l««s 14/1 1 t) Wats, 2.5 hr after 5. « ig as b\| 33.9 » or - »3.9 I solfate og/1 I 1 acalttr 21-32 rr old j BO ««tal hTP«reasltiitr 1 \| S«IOB!t; IDOLIS: BIOOO: BIOOO SEIUR; \| DII»: IICEEI 1- a) 3.25 + or - 2.33 1 at Baseline Talus 09/1 \| b) Peaks, 2. 5 hr after 5.« my aa b) 2S.7 * or - 31. 5 1 tilfate nq/1 ( 1 Health t 21-3! re old \| 10 letal fc7p«re»ltlTitr 1 siBDZT; >DHITS: BLOOD: BLOOD siaaa: \| DIXIE; nCKEl 1 23. 1 ag 1 « 1 stapled at rat of 1 1/ali, 2-10 \| iln after tuning a arc vcldlag rods. 1 OniTersitj physics shop, Vlocida 1 1 flOIIIa: IBOLTS; BBZaTR; C1LCIOR; I cnotiiK; cnonoi: COJPH; moi; I iiJB: »6»csB; ncrai; POIISSIBB: I S01FIB; TITlllm; TIUHOa; H»C; 1IB 1 potiini(H: rtms; I»OSTXZJL \| KROSPHHES: TStCI ElBSEItS 1 t 1 nriev. Pcotl«» la risk analrsis of I cancer i» It and Cr iidastry are I prvsentvd Tarioas coapoands ace I cited vkieh eaase cancer in practical \| «lpos«ce aitnatioaa. The> need foe I dose raglstration is e«ph«si»d. 1 1 ICBVIT: ClICHORtS; BLOOD PI1SR1; t miisi iiDisniu Breinii SITIWJ i cnomi; tmis; itcsn.; ciBcinsni \| TIIOSTtlil ITflOSPHEHES : IBCISTBISS; 1 eccipaTiovtt BaziiDS: «!OPi»sas 1 1 Berie. 2 npresentatire 1 pr«-aialr«is treatamti are I »•«!» ted. la f«asibilltT of a 1 aclistic, ac-vtsh poll c 7 for hair 1 amalyaia is cctliaed a>d serrortod. 1 1 tfTXCT: TPICI nmin: HUB; 1 losTBitii: msamsrr svtmes; \| IITUS; PBOTEIIS: COHP1B1TITE 1 ifiiuMiois; uvBnoa: miaviT; \| IBSniC: BilltJH: BBOHIfE; CIEBIOB; 1 cuciTjs; cBLOtnt: cnonvi; COBILT: 1 CCPTEB: enini: cisiiiina: eoti; \| lODMt; ISOB; LlintlDB; l»»t; \| HS1BSHS; B1K1BESE; IEBCOBT; I tCHBVnOBs ITCKCl; PBOSPBOBOS; \| MtlSSIIH; BIBIDIBI: SSLZIHB; 1 mico: sutti: somiB; STSomtm; \| SDIMl! TIB; TITIIIDS; TDISStZB; I me: IUCCIIUB 1 BZFEEEBCX I 1 Ckristeasen, O.B. Lag«ssot, V. 1)81 annals of Clinical aad laboratory science 1ir«s119-125 Christeasen, O.B. lmg»asoa, T. H81 Innals af Cliaical aad laboratory Science 1t{2»: 119-125 Ikselsson, K. B. Desaedeleer, G.S. Johausoi, T. B. Bincftester, J.tt. 197S Innals of Occupational B»gi«ne 1»:J25-23S varaeth, I. 180 Joaraal of Toricoloo; and EnTironaiental ff««lth «<5/\|: 12 W-1227 Chittleboroagb. S. 19 SO Science of the Total EDTicouent 10:53-75 (BtR ------- flcxel 140-02-0 II »tl 51.71. n 155 C. BP 237 C, Wt TO M Bg at 2090 C. 100 ll Kg at 2370 C 4311 Bale 4312 Orlne 4313 Brine 4314 Urine Inhalation HETBOD US . us •OIBBB OF C1SXS al 35 bl 18 c} 68 d] 33 e) 32 fl 11 a) 1 b) 1 SIRS: a} <10-90 og/1 bl <10-IO ag/1 c) 10-200 og/1 d) 20-130 ag/1 el 30-110 ag/1 f) 30-120 ag/1 al 13-54 ag/1 b) 25-47 ag/1 8 Ell al 28 or - 10 ag/1 b] 3D or - 20 aoyl c) 65 or - 42 aq/1 d\| 52 or - 31 ng/1 e) 68 or - 31 19/1 fl 70 or - 30 e»/l a} Bot given b) lot given enroll UTOBBITIOI 1 review of sorld literatare oa the accvnlatim and bioconcentration of (elected toxic trace setals in h1 and Cr industry are presented. Tatioas conponnds are cited «nlch cans* cancer in practical exfossre situations. The need for dose registration is •aphasized. ICBS1T; CIBCIBOatS; BLOOD PItS»: OIIIE: iieisniu HIGTHE: BCTICT-, CEBosns: »TU,S; no; EL: CIBCIKHSEB; IBOOSTBIll ITMSIBZBES; IIDOSTBIES: CCCOflTIOSU BK1BDS; XEOPUSSS a] contmls c) Besearchers, ainiaal Bl exposure c] Prodtct Sorters, soluble li d) Caleiaers, »l dust exposoce e) Extractors, exposed to dast and f) tester plant, ll oosder and li carbonyl ass expasare Values corrected to l.t q/1 creatisiae. Data also for ataospheric dost. 11 refiaery «orkers, 19-C4 yr old, petro-cheslcal sorters as ccetrola. IICKIU HITltS; UDOSTEIAL PHITS; DUST; mm; UIITED KHGDOB; cccn;»ioai nzutos a] Sorter exposed to dast of insoluble Bi cosponnds Peak at 10 at t) sorker exposed to aerosols of cclable (1 salts. Pea* at 11 as Dlaraal variation in bats. Ictksrs in coastina-sseltiia and electrolytic departments in (orvay. amis; IICKTL: KXCIT; tiiosTBiu I1IOSV9BBZS: OCCIJPITIOHL BltlBDS; IICCD F1ISR1; OBUE 1ERBEBCE Jenkins. 0.. 1»79 IP»-«00/4-79-049, 1»4 PP. Borseth, T. 180 Joornal of Toxicology and Environaental Health 6 <5/6\| : 12 19-1227 Horaan, L.S. Eouge, P.J.C. 197* annals of Occupational Hygiene 22:311-317 BogetTeit, I.e. Barton, B.T. Indersen, I. 1980 Journal of Occupational Bedlcine 22 (91 =597-600 (MM FIG11 •"' ------- Ilckcl 1MO-C2-0 II Itf 5.71. IP t»3S C, W 2«7 C, W 10 u S at 2«0 C. 100 •• Hf «t 2370 C (cortmrsD) TISSII «315 •rtaa «316 OElM EIKWiil tO«TE MUniCU since us us * " cram — or cists is * 1IK1 t.9-9.6 u«/l _ ) 0.3-3. WJ b) 17.7-202.0 tg m» ' .5 » or - 1.9 BO/I a) 1.5* * or - 1.99 b\| 69.56 t or - 59. « ••5 ctimi iiroiiHioi Etctota-pnclpltaUoa saspl« pctpacatlOB Maltkr 29-«7 yt old* •OIMT; IDBtIS; HOOD niSHl! OSII1: CCBValtTlfC ZTIlnTlOIS; fllaSfflEHSR inioDS; tiauniminoi; IIDUSTEIII taissio»: ncni: BETIIS • tl m«r «.« B4 i> nlfato nalUr 31-31 re aid smii; IDDIB; BUM»: suxa iirra; onti: ncm B'smcs Torjuuo. I. Zackarlaaa, H. cllalcal Chaalrtrj 2* (7) si 19- 1202 - CBElct«M«B, O.B. t9t •aaals of Cllalcal aad laboratorr sdaac* 111-84-J CJ-BM M IJ8.25. BP -S3.7 C. M ISO.T C. TP 10 •• B9 it 3B.O C nssot 1317 Irvatk tinsras tofTf •UtTTICIt BIT BOB OC-IS imun OF C1SJS 5« tJ»7 •aipl«s\| MMI •at «iT« IUI O.J48 15T/1 s«Mtric eillUl IffOMHIOl B«a«u»d »t 25 C ail 760 •• B licit C.0«* aii 1.J7 14/1 SMltbf. 18-35 yr old, »OB»olilBg> •TtM blacks aid caicatlans. Ckicifo. 11. Ilqldlr cg/l GIIIUL nroiittiof M«nr4 at «Bd of working i»j, f«aa ale Ionia 10-13 BIB. laboratory aasistaats «orkla« clta ocqlalc solrtBts. CCCWII101H utitm GSMatt: »Ml«; BU>01t CatCIBoen timnct l«1m«rt, 6. latacBBtloaal arcnlTos of OccapatiOBal aaA BBTltOBMBtal IMaltfc • 3-.1W-150 (tin ------- i en NBZM, 1.2-4i«Url- & CI) ct-no II IOC. 1C, IF -IS C. « 1«« C, TV 10 •• Ig tt 32. t C (CORIIDIO) tissn Bnatk •330 BriB* mosaic Bons tBaUaU.. luimcu BBTBOD ac-is •nc nmt or cms 5* on «BDl«) Bt * b\| « O 2 _ BUM Bat giT« •) Bot git«B b) lot gins e) 0-0.1* ag/Bl Bill 1.0 BO/1 saoBatclc a) 0.0037 * or - 0.0007 i»»l/kg CM ot toM) b] Trie* Ct lot ftTM BCBIUI UTOBBHIOB e Bg lovK aad «PPr o»»-Sliaa Halt 0.36 aa* 2.8 Bg/1 BBBltM. 1«-35 TT DU, BOBIBOxiBg, irtai tlacfeB aad caacadaaa. Caicago, 11. Bigifly coatrollvd «p«rli«BtBl coadltloB. IBEUI: IICCBOL3; IIUKHS; IDOLTS-, CBLCBInlBB EnBOCaBBOBSi TOUT 115 CtGliTC COBPOUtBSj BUUB ItUIOS; IIBlUTIOBl BXTMOLISa; iniBDimSl ' a) o-Tolaic actd gl««BcoBl4« (aatabol.lt), 2B kr «zcr«tiw attr 0.31 BBol/>g o-zTl«lw, oral. Paak la 3-< be E) o-lolalc add glvCQCoaida, attv 3 ti «xp««x* to 13* ppB tr-irlcaa c( p-BBtknipB«rle Bell (BBtBbollt), attac oecnpttloBal «POCBC« tO 17l«.B. B«tiBBt«d CTOB 9Kapa telBBtOTT** aaaa »a« S3 ft total). nl »* rr (vapor). f»lBt«r« in aaippatldiBg rard, a«aa ag* 32 jr. HUB: iRIBGUTIS: tllS; eccwHioBii iiittDS; wminoB tlPOSOU: 1K1TL HBRlLSj P1IB1S; 1IIUUIOB mctnci KrotoniBBkl, B.K. Braaaa, e.g. O'Belll, B.J. 1979 Joaraal of laalytlcal Toiioologr 3:225-23-* Ogata, B. TaBazakl, T. Sagikara. I. SblBBla, T. 1980 lataraational areklra of OccipatloBal aa« EBTiroiaeBtal Boaltk 6: 127-139 U) Ul cctaa« 111-CS-4 CI-BU tl 1U.21. B» 5t.« C, BV 125.B C, TV 10 •• B« at 19.2 C imti «121 Bt«ath EttOSOB lOOt I taunicu. IB1BU1) OC-S3 BtBlZB oi cats 5 (3B7 •»»!••) laKB lot glit* Bill 0.296 ag/1 eo««tcle ' cBimi iipOBamaB . _ 8«anna at M C ul T60 aa Bg 21. K oecnme loaac ud IPPBC oa-Slgaa Haiti D.079 >d 1. 10 ag/1 Kaltar, 1S-35 re old, noBtBoklag, »tu blaeka aad caaeailan. Ckleaqo, 11. ttgiAIr ooBtnlKl •P«rlMBtal oaBditleai. EBEITB; 1LCOK>1S: ItlllOIS: 1DOMS: CnCKIaTBD BTOtOCIBWISi TOIaTIU cHinc coBPtmns; IULTB aiuics-. IIBUITIOV; BKIBOIISI; mUOlRBS; tatmma* tttonn; »BU MEIS _.-._, IfcfBBIlCE Kcotonfaki, B.I. axBaaa, 6.8. C'Belll, E.4. 1979 Jooraal of taalTtieal Toxioologr 3:225-23* ------- Cctuolc acid, peatadecafliioio-, aeaonUe salt 3(25-26-1 Cf-R-T15-02.B3-I BS 430.98 1ISSOB 4322 Urine t EIPOSVU BOOTE • U1TTIC1L HETBOD ec BOBBES OF CISBS 1 SIEGE a) lot applicable b) lot applicable c) lot applicable Hill a) 387 eg/24 he b) ITS 19/2* hr c) 80 ug/24 hr GSIIBll IITOIUTIOI •1 1 »k b\| 3 10 c) 14 M Interval follo«ia ------- CI) . «-(t-MtkTl«tkrl\|- f» CI) II 150.22, Bf 2« C, BF 2«» C, T* t » Ig at 7«.2 C 1ISSII •125 Srtatk citoswv Bone uumcu GC-BS •DBBIt or CISTS 5* (317 •aaplfs) UIG1 lot giT« till ._ 0.2«1 »9/l GaoMtric Gimal IITOIBMIOt l«a»r«4 at 25 C aid 7(0 n 89 It. S* oecwraBO* lewt »»1 vppn «a%- slga, lliiti 0.03 aad l.ti Bg/l ••alt-VTi 1%— 3S yr old* BOB8BOkiii9r attn blacks ud eaaeaslau. Ckicaqe. II. tloiair coBtrvjUad icaria«Btal eaBditiont. E1I1TB; ttCCBOI.!; IlXIfOIS; IDBITS; cnoiinTti miocaiBois: TOIITILI C1GMIC CO8PCOID3; HH1TB B1I1IDS; IIBltkTICI: SIT1KJIIS; BETIBOHTBS; ropouTiot uposm: onii tins unmci i Braiaaa. S.a! O'Mill, 1.3. Jonraal of IMljtlcil 7oxicolO9T 3:225-234 I-Di«XtM It CI) 1.«-Iioxtce (» CI) 1J3-»1-1 C«-I«-02 11 €1.10. » 11.80 C. IP 191.1 C. T; »0 •• 19 t 25.2 C tiss« Bnatk Bnatk titosui JCHTI BMBCD ac/as ac-gs or cisis - - - 5 on sMplatf) I1IE1 tot 4tactad-0.a\| ag/br lot 9lwu Jill 0.05 «g/kr 0.253 ng/1 eiinii iiratnnoi CcifovBi r«laua to aonal Mtakollca. 10 etkar tetail gl»» CiTogoic aaipliBg tackolgB. laaltkr illitarr mi eiillai aaplor««a, o.s. ale Foce* School of Mraapaea BcdielB. ag« 23-7 yr. 3 nolacs. IlltZISS; CHOtlllTBD RDBOCHBOIS: cnmitt fiKjnc COBMIKDS: ciLCMBtnnis: nnotiij COBSOHIDS: EIUTI; 1ICCROIS; TB1U: IDCITS !«aanat at 2S C »m« 7«O ma 89 21. B< occnnne lame »nd upper aa-SiqM lliits 0.0«7 aa.1 1.37 Bq/l BaalthT 1B-3S TI olt, BOBiMkUg, CUcaqo, 11. tlgldlr coatioll«4 «ip«cta«Btal coiditiog. {1119; ilCOBOiS; IILIKIS; 1D01TS: CIIOIIUTtD RBMCtlBOIS: T01ITHI tisnic coitcnDS; nun BIZUIIS; IIBlllTTCI; aitlBOlISB; attlBOimS; fopntTioi IDOSVR: otan mis HTXRffTCE Coakte, J.I. Caap, B.a. *lea. B.I. 1»7S lreklT«0 of ZavlroBBCBtal Rcaltk 30(21 :2«0-2«5 CtotonjBskl, B.X. D'lallli ••>'. •\m Joarasl of taalrtlcal toxleologT 3:225-23* OJ ------- (I CI) Cyclokoxcaa, 1-B«thyl-4-(1-Mtkylthmyl)- (9 CI) C10-B16 If 134.23. K 174.6 C. TP 1 u Bg at 14.0 C 1I3SOB 432» Bxoatk BXNsni toni 1I1LTTICU HBTHOD OC-IS tana or CUES 54 (387 •aipics) S1IGS lot givra BUI 2.9 ag/i 6«OMtrle 6SIZB1L ICFOBUTIOI Ma«U4 «t 25 C »d 760 aa Bg 94.5* ocetrrwc* lowtr aal ippar o>-SiqM limits 1.07 •>4 7.9 B9/1 Icilthr, 18-35 TT oil. aoBSMkiag. irtan blacka ud CMCuicu. Ckiecfo, n. llgUlr eoBtroll«d «sp«rlimttl coiditlOB. Ellin: ILCOK>LS: IILIKISS IDIHTS: CtlOBIUTIV IIDBOC1BBOBS: TOI1THI cieinc coircons: HMITH usues; IHItlTIOI; 8R1B01ISI; BBTUO1RBS: loraimoi nnsoii: HIBM tuts nnBEBCB KZOtOSTIBSki, 3.K. Br«B«fta« G.H. C'Klll, B.J. 1979 Joarial of faulytleal Toxlcolegi 3:225-234 ' -»k««Tl»«Uula« C CI) 4-SnMMdlailM \|9 CI) 106-£0-3 C6-M-I2 II 108.7 C, H 1W C. BP 267 C IISCTB 4329 orlM BXPOS0B BORI . 1U1RIC11 •BTBOO IV1BBB OF CUBS 11KB mi 6EIEBI1 IirOIUTXOB l«Ti«w. Xocil ui TSt«iic «f fccts c«l«tli9 to kair IT* fonalatioi. l4t«dl««t testa, til •xp«ti«ac«a In IIB and aiiials. Cmtaet 4«riatitis it uan. tktir tfoiMS, dcatists or etlwra in ccataet vltk tcecatly 3l& hate. Iaa«dlat« krprmaltlYlty lirticacia) ivpoctei. ItOHSi DBBIKITISi IBOPI1SHS; BSI««; II TITBO II1ITSIS; II TITO 1111 ISIS; IZTIBV; DIBS; CUCIIOSEB: COSBITICS; SIIBTIC BFrBCTS; nUTI I1Z1B9S; IIT1BOIISR: IR1BOLITBS BBFBBBICB larziUll, r.t. 6re«a, S. •alback. B.I. 197* Jovraal of BaviroBBoatal Pathology and Toxicology 1! 509-530 U) oo F-Tolulfakyte (« CX) Hnxalookyl, 4-Mtkyl- (9 CI) 104-B7-0 Ct-»8-o (I 120.16. BP 204-205 C IISSOI •330 Btaatk t I BXPOSDIB BOnX iiumcu HBTBOD OC-BS 1 t BOIBZB OF C1SBS - 54 (37 M«pl«S) 1 » 111GB lot glT«n I BB1I J.3 »g/l SeoMtrie 1 6IIIB1L IirOBUTIOl laasvrod at 25 C a4 760 •• Bg !.7f occirrvac Ic«r aad ippr OM-Sigaa. llaita 0.7 aa4 15.4 ig/1 l«altkT. 18-35 yc oH, soaaaokloq. •ttaa blacks aid caacaalaaa. Chicago. XI. ligidly controlled aip«rla«atal coaaitloM. (1BRI: HCOB01S; lUXKIS; UHIIS; CnOlXHTIB IIDBOC1BBOIS: TOtlTILI CIGWIC coBPcnDS: IUITH iituns; mtllTIQl; IBTltOLISfl; ItlUOLTTES; I (O?«U1XO« CnoSVR; «BB» HEIS 1 SZRMICB Krotoaxyuki. S.It. Braaoaa. 6.B. O'H.ill, B.J. 1979 Joaraal of analytical Toxicology 3:225-234 ------- «»a (« co IUMM, 1.4-41actftrl- 19 CI) 10«-42-3 CB-B10 •I 10C.1t. «f 13-1 C, n 137-138 C, »* 10 II B9 at 27.3 C TISSUE •331 IlaoS 4332 Cnata 4333 traata sitosrac sons lakalatton 11U.TTICU, tames oc sc/is SC-BS mnxi or CUBS * * 5* (37 saapl] 11161 1.04-1. (9 tg/i lot 4«tct«a-0.»03 ig/hr lot 9l*a m 1.3075 »o/l 0.000* oaAt .. - 3.1 ng/1 SMMtcic 6IBHU, nromixoB It p»r« » Mta, Mau«d «t od of forking 4a\|. B«u lr !«•!< 5«-6« *•- CCCIMTIOIII BI111DS; SB1B1II; HULTS; BLOOt; CUCItOUII Ce«poi«l ftoi ukion oriqla. >o «thr 4«t«ll« qlnc Ciragvmie «ipliiq tcehxlqo. Bmltkr illltacT ud clTilUs «iplor««9, U.S. lit Force school of l«nspc« ••fllciM. «?«s 23-*7 jr. 3 iiolwn. tlllltfS; CBIC1HKIB RDIOCUBO1S: cBioint oisinc coiMms; CBiciosmnts; nooitn conoviDS; HiiTB; iicoBois: THIS; icnvs I«>drtl «t 2S C «a 7SO •• Bg 9t.7< oceoTTcne lenr M4 vfpct OM-slqu llilti 1.2 »4 7.4 B9/1 BtaltkT, 1S-35 yr aU, noacMfclng. ntu bl«ck> Mi nietslu. Ciiragot 11. liqidlT ca»ttollA «lp«tlwit«l cotttio»s. Itlltl; HCOBOlSi IIIIIOI3; lOOltS; tBtotiiiTiB iraiociiwis: foums aiamc coRfcnDS: HILTB IUUDS; HBiittia; reritouss; IBTUOLIRS; icmnTiof inosiu: D»B»I usts itrisnci tnq»r, J. I«Ia«ct, 6. H7» Interaction! icchlTca of Occvpctlonal ana initoaMBtal B«ltk •3:154-150 CoukU, J.P. Ca«p« B.J. Mich. B.I. 1»7S liefeln of fariroBMntal B««ltb 30 (2): 20-295 KrotoczfMki, B.K. Braa«a« 6. B. O'Mlll. B.J. tm lonnal of laalytleal Toxicology 3:225-23* to 1440-05-3 I« It! M«.4. II IMS C, « 3167 C. n 1 aa Bg at 170 C. 10 aa Bo at 2290 C IISSOB «33 lAlBOB* IHOSDtl WJBTl HllRXClt BETBOD US 10B1S1 or casts 10 (1KB - - Bat gti«a . {•in SEtl O.« pnb . rteo eimti nroiBMiOB . loa k«7«l«« nciteat* UtopiUa, 12-79 rr olds. ntus; pnumB: PIILIDIOII: isu>s TOfDllTIOB BimSOIB; OCCONTIOBU Bixites: cunosBii: iirropsr«s; HOOD; 1IDKIS: SniBB; Bill; D1I1B: HISS; «VSCltS; UIMSB TISSUI; HTM! COBtlUNfB EIliH«IOlS: BS< onsiT: calm; BIS»B: IOTOBOTITB •EtEtXBCB Johaoa. O.E. Fc«oct, J.J. T111«T. l.t. Caaaaa. 9.1. (OMafela. J.B. 197C B»-«0«/1-7«-019. 235 PP- ------- tainau 7MO-05-3 n Itl 106.. at 1S55 C, If 3167 C, TP 1 aa Bg at 170 C, 10 M Bg at 2240 C (comnsoi IXSStll 1335 Hood •336 lilr •337 XldMT •33* 1 1 MI xxtoson tooi 1 1 1 1 t 1 t immcu EETIOD US us US us •oasis or CUES 2»3 23 10 met a) lot git«n b) lot giT« c) lot si no lot giro lot sires 'ot givaa SMI I cEBtiu iiroBBinoB i IETESXICS 1 1 1 t i) <0,9 19/10 «1 \| i) lorn ligclaa aad laacastar \| Jekaao. O.K. b) -»• 1 «>fl 1 Cuaia, D.I. 1 c) Iue»t«r rtaid«ts. cotjwsita \| Hos«afeM, J.I. I ««npl« \| t»7S t I CTI-«00/1-7«-OI9, 235 1 CiltforilM liTiig do»«ii4 fro* a I pp. 1 tk« kigfc I I 4<>ert rwjlei of lue*t«r. »g« 1 1 gtonps: 1-1f. 17-34, 35 or mor« re. \| 1 «OV «hit«, »0« aoa-ihlta t lo> I 1 >•«•!«. 80* «klt«, 20* »oi-«hit« l» [ \ I«eist«r. \| 1 \| 1 inus: pinnras; ruium: tin; t t iefOLKtiai KPOSOM: occopuiofit i 1 nxiEtS; ctiirotnt; itrrofsizs: i 1 HOOD; (IBHTS: SM.IEI; uii- raill; 1 1 muss: mscust ivttost Tissra; i 1 iirra: CORPIMTIR tniUTioiSt »s» i 1 JESSiT; CHIN: mm: UTOMTITI i i - - - i 1 ! <0.02 aaV9 1 lo* MaolM «nd Laacutn ro«ia«nt« 1 Jofcnson, g.i. 1 \| Pt«TOJt, S.J. 1 callMntai* llrlaa dovnled Iroa a I tilled. J-B. t ft««»«T In Ic« lag* In or in tk* kiafc I Caaaiia, O.K. 1 d«Mrt caglci of laactttcc. lg« \| BoMafcU, J.B. 1 atoips: 1-16. 17-3». 35 at oc« T. 1 «T« 1 tot chit, 0f 90t-«kita la tos t Kl-600/1-76-019. 23S 1 Jn^«l««. to vklt, 20< aoB-vklto ia I pp. 1 laacastvc. \| 1 »TRS; PLITHUB; PHUDIOB; 1EID; 1 1 ICPtUlTIOR HPOSIHIt; OCCOP1TIOIU. 1 1 IlliS IS; CllITOMIl: tVTOPSIB; 1 i ztooo: KIOKIS: spun; HIIJ; nun; i 1 tO«SS; !I9SCUS: 40IPOS! TISSOI: I t iifEt; coipitinn miMTiois; n t 1 JttSBT; C1I1E1: IIIIK; 10TOBOTITI \| 1 1 t 1 7 ppt f toa la?al«a r«aiil«>ta I joknsoa, P.I. 1 1 Prorost, ».J. 1 latopsUs, 1Z-7« rr old». \| TUl«rr, j.». t 1 C«a««n, D.r. I HT»is; PIIIIIIB; PUIIVIOI: LBID: i goatf«u, J.B. I Topnmoi EXPOSOIE; OCCO?ITID»M. i 117* i Binars; curromi; IBTOPSIIS: i iM-«oo/i-7t-oi«, 235 1 HOOD; KiDBtis; SPIES: nit: ttn»; i pp. t loies; SOSCKS: taiposi tissast I 1 IDtP.; C01PIHT1TS tfllVtTIOfS; RV I 1 JHsn: ci»u: mites IOTOIOTITI i i i t ppt \| lac la«al> resldeats I Johasoa. D.I. 1 t Iftnst, i.j. I Ittopsios. 12-7* rr olds. I llllwr. J.B. 1 1 caa»n, D.I. 1 fltlLS: PIITITOB; puikBiai; ttiv: I BosaafaU, J.B. I lOPOHflOI IXPOSVIE; OCCnPITIOBJL I 176 i B im«; CU.IIOMII: amopstiss i Kp«-sao/i-7«-oi», 235 1 HOOP; KIBIIIS; SPIMI; Mil; milt; \| pp. I ines; nvscits: asipos: Tissue- i i tun: coRpimxn mmiTiois; n« i t JHSlt; CHItt; ft IK; 13VMOTITE I 1 1 (Kit PIGE\| . . N> .p- o ------- falladi! 7MO-05-J ft M •»«.«. n 1555 C, SP J1S7 C, fp 1 •• Hg at 1»tt C. 10 » Eg at 2290 C (COBTMBED) nssoi 4339 LHfifl aaWinj wo 3«1 3«2 Oriaa iiposon BOOH tinmen •ETBOD US US us us BWBEB OF C1SES 10 10 10 a\| 203 b) S8 I1IGE lot glTn Mot girea - — lot gitaa a) Bot glfea b) 0.10-2.61 ag/1 Mil <3.3 ppb <2.2 ppb a) <0.3 ag/1 bl 1.07 » or - 1.68 ag/1 ««ni i»o»»i<» lea lagelea caatdcata latopaim. 12-79 yc oils. BFIILS; PHIIBOB; MtllDIOB; 1EU>; PCPOHTIOI 1IPOSHBB: OCCDP1TIOHL tazutfiS; ciiirtnni: IOTOPSIES: P.1009; KIDIII3; SPMEl: Ball; null; miss: mjsctis; iinposi TISSDI: iiTij; coHPaunrr EniOHiois; IEV JEBSET; Clllta; BtlHG; moBOTITE loa lBgla xaaldcata lotopaias. 12-7» TT olds. EIT1IS; PlaTIBDB; P1LHDIOS; LIU: corniTTOi EjposDEB: occur ITIOI it. « ins is-, cinpoBinj imotsizs; BIOOD; nmns: SPIEEI; B»B: OEIIE; UIGS; BOSCIB: 101 POSE TISSUE; IIVEB; COKPltaTITC ETtLDITIOBS; IER JtBSEI; CUata; BIBIB6; inoBOIITE lea laaalva naideata tntopalea, 12-79 TT olds. enus; PI1TIBUH; PUIIIIDB; LBaD; topoiiuoi txposrae; OCCOPITIOBU aiziBDS; ctiiroBBia: ITTTOPSIES; BIOOD; KIOIZTS; SP1ECT: Ball; UBIIE; 10IGSJ 10SC1ZS: 101 POSE TISSOE; IITBI; COnallTITE CTHDaTIOBS; BIV JIBSEI; Clllla; BIBI1S; 1DIOBOTITE at los lagelaa aid Laa caster c«aid«Bta t) OccanatloBallT cxpOHd. Bighast »«!»« i» stoiarocm »oiX« CalifocBlaaa litiag dovnvlid £ loa a fracnar la lea lag«l«s or IB the high d»«rt reglaa of laacaster. iga gtospa: 1-16, 17-3. 35 01 aoi« ------- t«ntaa«. 2-ntkyl- 1C7-83-S C«-B1» n 86. 18. ft -153.47 C. It 5«-«fl C. It 109 •• "« «t • 1 C IIS SOI «3«3 MPOSIIS BOOTI iBkalatioB t»i. mot HXTBOD ec/BS loam or cuss 10 I DOS 0.5-5.1 19/1 Silt 2.5 » or - 1.6 sg/1 siiini IITOSUTIOI is 2-awtkyl-2-pataBol (••tabollte) Icrters In ska factory IB Italy BBiiE; BTDtocauois: inuoims; mil: iiBDsniii ITBOSPHSBIS: IlIDSniU BTGIBK; XB POllUTIOl; OCCDMTIOiai DXSI1SSS nrzszBcx P«rb«lliBl, 1. PT«BV I. 1980 Toileology and Ippliai Phar.acology 53:229-229 «. 2.2,-trlMtkyl- ••O-M-1 CI-Btl II 1U.2. tt 99.2 C. TP O.C •• •« at 21 C IISSOI «3«« Br«ath Biposni toni IMlItlCll •moo GO IS IUHBIB or CISES S* (387 saBplra) I1ISI Bot gir« Mil 0.60* Bg/1 G«OMtrie GIKIlt IirolBITIOB §«aior»a at 25 C aid 70 •• 89 29. ?t occurrence loocc aai ------- CC-I1 •i tf.n, BF 63.3 c, TF in mm 09 it lo.s c IISSVI •36 DrlM IHOStB BORB Dvraal 1UITICII •SWOB «C/BS I lOHEt or cuss 10 I1I6E a. 1-1.1 ig/i . Bill 0.5 » or - 0.» mq/l enziii HFOI-UTIOI is 3-ctkTl-2-P«tamol (»talx>liU) Oat also «s Eolnatx is factory ail 1«rkt» 1» aho factor} in Italy inn; nnocmais; nruoutis: nui; iiogsniu IMOSFRIIS; IKOSTtllt neiltti III POI1BTIOT; CCCVFKIOIll IISIU13 - •EFIUICI F«rb«Ull. 1. iteo Toilcologj aid Ippllad PharaacolojT 53:220-229 {•ctuelc 3JJ55-3J-I 11SS11 »3»7 imtk TIJOSOSI 1ORI uunicii HRBOD SC-BS man or cuts 5« C37 OMflW) I1H> 1 1 1 lot gir«B Sill 0.062 ig/1 G«oa«tcic eilttll IlFOttlTICl Mint! «t 25 C »a 70 » Bp«r oM-sifn liits 0.032 «l4 0.114 »V1 l«»ltfcT. 1«-3S Tt olfl, noABMUiig, «rt»» blicki «J Caucasians. C41cai]o. 11. lifillr coattoU»a • ipvrtmtal oaoditlaai. HIITB-. 1ICCBOLS: IUIIOIS; 1DV1TS; tBLOHMIID ngBOCanOIS; T011TILI tlSlKC COBFCraiS; 1ULTB B1IIBDS; iiiumci; BEIIBOIISB: airiBoirris: raFOiiTioi xiFosnE; ami istis imsracB KCOtOSXfMki. 8.X. BTUMV. G.l. O'Weill. fl.J. 1«« Joaraal -of Inalrtical toiicoloqi 3:225-23 laatil alcatel (» CD 1-lwt»ol t« CI\| 7V»1-0 C5-I12-0 ii w.i. w -T* c. BF m.e c. IF i » B« at u.t c. 10 u it .S c 1ISSHI t 1 I 3«f Bnatk BXFOSIB KX1I - uuniciL action Be/us " BUBBEl OF C15XS 8 Rim •at 4«t«ct«a-fl.6D ag/kr (HIT «E»» 0.13 V9/1T F1GE) SI»»t TIFOtBlTIOl CeFon4 r«l«t«fl to aonal i«t«bolisa. lo otk«r detain qlnt CTT»9«aic saapliaq tccbnlgt- B««ltkT illltarr ail ciriliai «iplore«». 0.3. lit Tare Sckool of l«rospae« a, a4«s 23-«7 jr. 3 saokera. IfllEfBS; CBlCBIlltIO ITDtCCHBOIS; CBtonn 03S1HC coBFoms: tiioioBnzim; nuoBii! COBPODIDS; tBtlTf: ItCCBOU; 1EIIS; 1BBIIS nnanci COBil. J.P. C»«pr B.J. Mick, B.I. 1»75 irekiraa at FBTironacnttl H«»ltk 30(2):2<0-25 ------- alcohcl (8 CD 1-Pentaaol (9 CI) 7 IT* 1-0 C5-B12-0 n 88.1, IIP -79 C. It 137.8 C. TP 1 •• Eg at 13.6 C. 10 •• Eg at ».9 C (COEIXI9ED) TISSUE «3»» Breath ntosDBX BomB IBalRICll BET BOD GOBS BOB EBB OF C1SES 5 (387 saaplas) B1B6E lot given Bill 0.505 ng/1 Geometric GBEBB1I, IiroBBlTIOE teetered at 25 C aid 7«0 •• Eg 21.7* occurrence IOMC and apper oae-Sigaa Halts 0.128 aid 1.99 mq/1 Btalthy, 18-35 yr old, nonsaokiag. gttaa blacks aid ca«ea«tai». Chicago, n. Kigiair controllaj •ipcriMatal coalitions. EHITfl; ItCCBOLS; IllIIOIS; IDD1TS; enoiiMTte imociiMis; TOUTHS CIS1IIC COBPCUIDS; BJilTB BltlRBS; HBIL1TIOI: BIT1BOLISI; BEtlBOLITBS; poroiiTioi ziposaiB: OBBIB u»s SBFBBBICB Krotossjaaki, B.K. Braacao, G.B. O'Mill, R.J. H7» Journal of inalftical Toxicology 3:225-23* 1 Ihtaol 108-9S-2 CC-B6-0 II 9«.It. HI W.85 C, BP 182 C. T? 1 aa tg at »0.1 C Tissue • 350 OCiM • 351 DtlM BIPOSOBE BOOH D«raal Inoestioa Jllimcil HRBOD 9C OC ins Bra or cases a) 15 b) 0 a) 39 b) 119 BUSS a) 1.0-5.0 aq/q cr«atinin« b) 5.2-13.2 ag/g er«atiaia« a) lot gira b) lot giea HUB \| eilllll nrOBIATIOB 1 a) lot giTen \| a) Coitrcls b) lot giv«B 1 b) Vorkars espos«d to chloropheaols 1 1 Icrkats in herbicide laaufaetaring I plaats. 1 \| BfBBICIDES** UDVSTKZ&L PLANTS! 1 OCCOPlTIOItl B1ZH9S: PISTICID1S: I fOPOHTIO» HPOSISE; BS1SU1BEEIT \| BITBODS; CBICBIIB OB61IIC COBPODBDS; I tttlOlS; CIB1S1; 7BIBE 1 a) 11.97 » or - 11.60 I •) Besldaats lliinq 120-310 a fcoa •9/1 \| still site b) 11.56 « or - 10.86 \| b) Coatcola KJ/I 1 B«asar«d « mo after Incident 1 >0.1 ag/1 fenad at least oaee in veil 1 «ater of study group 1 1 Bcsideats of East Tror, II. site of I accldeatal rail car spill of 37,900 1 1, 197«. 1 1 Ciarrhea. aovth sores, dark vriae. 1 taraiig loath, reported by 1 significantly eore persons In study 1 groap than ia controls 1 I BISCOBSIl; OIXBZ: CCBPmTIK 1 BULUITIOIS; PBBBOLS; DBIHIB6 1»EB; 1 6BOn9 »T(B POlLtJTIOH; BETlBOinSS BZIEIEBCB Tan Koogaalen, p.B. Klein, 1.1. Draaaond. I. 19«0 International IrchiTOS of Occapatioaal and •5:5>«2 Baker, E.I. landrigaa, P.J. Bertozzi, p. I. Field, P.B. Pasteyns, B.J. Skinner, B.C. 1978 Archives of EBTiroaaeBtal Health 33 (2) : i9-« ------- fttmel, c-ckJoro- ft CD rkeiol. 3-ckloro- (9 CI) tOf-U-0 C6-BS-C1-0 II 121.58. » J3.S C. BP 21« C IlSStff • 152 tlaoi. viols WWSflS 80 Ott ilUTTIClI HETBOD BMC inatra Of CISSS a) 35 b\| U BliGE ] 1-i« »«/g »l 32 -U D4/g BUI a) 19 ag/g li\| SI »»/g [ GIIIUL IIPOSU-IOI «\| loia Canal rullmt. « (1C) FCiltlra l\| tolwtMca. 1st (2) positive Huge n ------- fhnol, p-ehloro- (8 ci) Iheaol. -cbloro- t» ci) 106-M-9 C«-«5-Cl-0 (I 12S.S6. H «3.2-«3.T C. SP 220 C tissos «33« BlOOl. • bole JIPOS01E BOOM imnxcii RTBOD HP 1C IB8BSB or CASES a) 3« b) 13 flies a) 1-90 a«/g b) lot applicable mi a) 29 «o/g b) 2 a«/g GiiniL nroiRHioB a) love Canal residents. 29 (10) positive b\| Tolante«r>. 8* (1) positive laiq* aal aeaa of positive aaaples. Tilaes corcected for tecofety Closelr satched, sisaltaneois control sasples >ere not pcorlded foe •aalTsis aloig «itk those ftoa the 36 IOT» caaal acea r«siA«ata sa«pl«d. lacklnq seaalavfal control or litecatace data relative to the siwiflcance of the lo» reailaea toned ia the field saaples analfxea. ao tefialte conclusions can be dra»n froa the resolts reported. lesldeats of lev Tork. Controls, esplovees of the SaTlroaseatal frotection loeacy aad oaiTcraltj atadeats. lorth Carolina. II« TOIK; 10ITR CUOUM; BLOOD; Bitsnzgsii mooDs; CHLOSIH OBGIIIC CCIPOH»S: ciioioBtmns: IIIaCHLOROBIREII; POITCEIOBWHID fI«»ITLS: POPVtlTIOl RPOSOI8 mtSEICI Bristol. O.I. 1960 IP1-600/1-80-03. 0 pp. (heaol, p-altro- (• CI) thesol, -altro- (9 CI) 100-02-7 e«-»5-w-o3 M 139.11, HF 114.9-115.6 C, BP 279 C (decoap) to IXSSII •3SS Oriae IIPOSOU BODTI 1IUTTICU IZTBOD SC •OBBEB OF C1SIS 12 I1IGE 0-0.5 ppa 8E1I lot applicable GEIIilt IIFOM1TIOI fang of seaas daring cotton spraying caaaoa. RonthlT levels correlated •ith orqaaorhosphate pesticide ase. Cetton insect scovts, college-aoe, •orkiag vithcat special protective clctbiaq, bitalag » ith In 2 hr after dallr «ork. 1C algns cr «Taptoa« of orqaaophaspbate poiaoaiag. levels iavereelr related to blood ehcliaesterise activity. IISnCIDSS; tniBOtlTSS; OIIIE; atOlfS; OieitOPBOSfUTIS: cccopHiomi guuis; tnnis FIFEBEJCI Barns, J.E. Parker. B.fl. 1975 Archives of Znviroaneatal Contaaination and Toxicology 3:3«-351 ------- faeaol. peitacaloro- tl-tt-S C«-B-CIS-O SI 26C.3S, H 190-191 C, B 309-310 C (decaap), TO »0 an >« at S11.2 TlSSffl • 356 Blood, HEM •357 Hood, aania «35« Blood, vkole msiu lont akalatlon I>ka la tl 01 aiaimcai BSTHGD nic IOUZ8 OF C1SES I 2 1 32 0 T1 •22 a) 35 b\| 12 illGE ) 1.68-1.15 ppa ) 0.116-1. OM ppa ) 0.015-0.055 ppa a) 0.15-17.* ppa b) 0.02-7.70 ppa c) <0.01-S.«0 ppa 4) 0.02-7.20 ppa a) 3-39 ag/«. b) 3-15 ng/g (III] mi a) 1.72 ppa b) lot given e) lot given a) 3.7» * or - 3.99 ppn b) 1.72 * or - 2.02 ppn cl 0.25 * or - 0.88 ppn d) 0.32 » or - 1.25 ppn a) 13 ng/g b) 7 ng/g P.BB) •" " 61IEI11 IIFO1UTXOI «) Girls, aqca 2 and * yr. Iron log teae «itk 0. IK on Interior mod nc face, 0.2f « ------- Chenel, pentaehloro- 67-85-5 ce-H-cis-o >« 266.35. HP 190-191 C. BP 309-310 C (deconp) . It 40 H at 211.2 (COITII32D) IISSOE 4359 Urine 4360 Orine EXPOSURE ROUT Inhalation Inhalation IHLRICIL BET HOD lUBEEB or CISES a) 11 b) 33 e) 1 422 I1GZ a) 2-87 ppb b) 1-7 ppb C) lot applicable a) <0.01-7.80 ppn b) <0.01-2.40 ppn c) <0. 01-0. 40 ppn d) <0. 01-1. 00 ppn 8E1I a) Wot given b) Wot given c) 216 ppb a) 0.95 or - 1.93 ppn b) 0.27 * or - 0.56 ppn c) 0.01 » or - 0.05 PP» d) 0.03 * or - 0.18 ppn GtlZBil IITOBimOI a) log hones residents b) controls, untreated hoaes c) 2 yr old girl fron log hose sith 0.11* on interior vood surface, 0.29 ng/cn n in air logs dipped er sprayed with 5* Fentachlorophenol Kentucky residents of log bones bnilt retneen 1975 and 1971 Controls. 10 pentachlorophenol-related health croblens. KHT0CKT: (DOLTS; CHILOREI: BLOOD S1BOH; U3IJI; roiGICIDBS; FOFDLITIOI HPOSORJ; PBE»OLS a) Open-vat sood treatecs b) Pressnre-tank rood treaters c) Parners or pest control operators d) Controls Occspatlonally exposed subjects or centrols in HI. Increases in innatnre leucocytes and rasophils, plasna cholinesterase. alkaline phosphatase, gnita globnlin. and nric acid. Decreases in serai c«. I111II: 1D01TS; BLOOD SERB"; OBI»H; IIR1CRLOIOPBEIOL: BEILTB B1ZUDS; IinaSTRIlt IIBOSPHEIES: IIBU1TIOI SEFEREHCE Belt!, 8. I., Ed. 1980 Chenicnl Regnlatioa Reporter « (26): 823 Kleiner, B.s. Vong, L. Sato, 1.1. Beicbert, B.L. Korsak, R.J. Rashad, H. H. 1980 archives of Environnental Contasination and Toxicology 9:715-725 00 Pbatol, 2,«-Jichloro- 120-83-2 C€-B«-C1J-0 II 163.0, IP «S C, BP 209-210 C TISSUE 1361 Blood, •kale t t I * XXMSOtB SO DTK \ \ t IMLniClL RETWD me 1 t « M01IIR or cisis «l 35 b) 13 t _l I1IGS - •) lot applicable b) sot detected 1 « i IE1I • a) 5 ng/g b) lot detected \ \ GlIEBlt IiroRUTIOl a) tove Canal residents, 3* (1) pe«ltie b) Talnn teecs lean of positive sanples. Talnes corrected for recovery Closely Mtchcd, sinaltaoeons control saeples vere not provided for analysis along vlth those fron tne 36 love Caaal area residents saspled. tacking neaningfol control or literature data relative to the significance of the lo» residnes fcand in the field sanples analyzed. no definite conclasions can be drawn Cron the resalts reported. Issidents of lev Torr. Controls, eiployees of the tnvlrouental Protection agency and (Diversity stadents, lorth Carolina. Ill TOM: 1CRH CMtOUIt: BLOOD: aitsoBmni IRHODS: CBLORIIE oBcinc ccuponios; cau>BOBtit»ss; nniCVlOVCBIRllt: KUTCBIOBHITID 1 fUBllTLS; TOlnUIIQl nCOSTIBB 1 lEfERHCE Bristol, 0.. 1980 EPJ-SOO/1-80-036, 40 pp. 1 l ------- Phenol. 2.»,r-tcichloro- C6-S3-CU-0 Rl 17.5, IT 2S2 C. It 1 •• 04 at 72 C IISSBI 3C2 Blood, •hole EITCSVH tamt Hitmen MTBOD 8PLC • IDS in OF cms a) 35 i) 13 UK2 a\| 2-3 ng/g t) lot detected mi a) 3 »g/g b\| lot detected 1 1 efttm iBTOSBMiot a\| lore Canal residents, lit (t) positive b» Volvftteera tange ago Be an of positive staples. Values corrected tor recovery CloselT Batched, simltaneons control saaples me not provided for aaalTsls alcng with tHoae Croc the 36 Io»« canal area cesUeats saapled. lacklaq aeaninqfal control oz literature data relative to the slgalf tcance of tke lev resificei fooBd In tie fleU sacples aoaljiea. ae definite conclanioas can be dravn Iron the reavlts reported. l«>llents ot ••• tort. Controls, cnployees of the InTicotaeotal Protection locncr and naiTerslty etgdents, lorth Carolina. Ill JOtK; Km ClBOLUl; BLOOD; HIlSriSMKlT BBTBOBS; CBLO1II1 OSG1HIC CCIMBSBS; CBlOBOBEIIHESi l»tCRIOICBtn»Z; POtTCBLOBUlTEB tlPS!«LS; VCnUTIOI CTFOSDIE IEPESIBCE Bristol, D.I. 1980 IP»-600/1-80-036, BO PP- Ihenl. 2,»,«-tric«l.oco- 86-06-2 C6-B3-C13-0 » 197.5, HP 68 C, BP 2M.5 C, TO 1 an Hq at T6.5 C N> -P- VO 4363 Blood. AVtltllCAl BETHOD HPLC BUHBES 07 CUES a) 35 b) 13 luci a) 2-« ng/g t) lot detected (HIT "" a) 3 no;/g b) lot detected PiGE) G"mt "»««««• «) love Canal resldmts, «» (2) positive hi Tolonteers Bange and nena of positive sanples. values corrected for recovery Closely natched, sianltaaeau control sasilec ere not provided for analysis along with those Iron the 36 love Caaal area residents «a«ple«. lacking neanlngfnl control at literatnre dnta relative to the significance of the lo> relidoes fcond in the field sanples analyzed. no definite conclnslons can be drain fren the resells reported. lesldents of lev lock, controls. •itloyees of the Invironnental Protection tgency aid eniversity students, locth Carolina. in tOBi: ions cuouBi; BLOOD; flUSTJBMMT BIT BOBS; CHLOBI1B OBG»»IC ccaioiiDS; CBIOBOBHZZIIS; IIPHIITLS: POPHUTIOI EIPOSOIE tEFIBEICE Bristol, D.». 1980 1P1-SOO/1-80-036, ao pp. ------- fhaaol. 2.4 Fro cord coatrol* aaol/1 \| «] Fro* infants with Titaaln i) 1.76 » or - 0.31 1 tipplecent aaol/1 1 (1 Froi infant controls e) 2. 56 » or - 0.43 I tea* of 10 aa. uol/1 \| f) 2.73 * or - 0.40 I 506 pregnant voau, 613 pregnant aaol/1 1 centrals. Scotland. j 1 SCOniBD; DinCT ntSDOB; IDOT.TS; t lirins: BIOCI: OBBIHCIL COBB: I ClICIUl; BTDWITCHOHC»LCIUBOIS; 1 Bisnsng; BIBSULS: nosnosas; 1 T41C? BLBBCB1S; TmnTB' PS OIST5j I BIIZBlt BRIZOLISB; PIBGItlCT 1 \| a) 3. 51 « or - 0.07 f a\| Kaasas Cltr. ts, harl-iater ar«a •1/100 1 \| b) Kansas City. BO. soft-Hater area b) 3. 66 or - 0.04 \| •g/100 il \| IS and to reslients satched for age 1 <>aa agas 37 ana 37.7 rr), sex. 1 langtli of cesldeHe, larltal aad 1 aeonosic states, occapation, naalwr I ef children, ssoklag habits, it, st. 1 1 I hari-ratex araa. significant 1 licreaw in kyperteaslon, ICC 1 afenocsalitie. and kTPecariceaia. 1 I iiisis; iisseni: anBits; i ciiatoTiscnu DISSISSS: i Btmnisxci; sroon snoa; t c«aPUiTiTt triminois: cimitii: I CUCIB«; cncBini: imtius: I tieissiva; t«os?Bo»oos! FQMSSIOB; I sctiasj me: Bioiccmnmoi: 1 ninais BIID i IIFESEICB Cockbar. F. Belton, I.E. P«rTl», I.J. Giles, B.B. Browa, J.I. Turner, T.I. VllkiBSOl, E.g. Focfar, J.O. Barrie, I.J.B. BeKar. G.3. Pocock. S,J. 1490 British Radical Jomrnal 28 1(6232): 11-14 Biareabaaa, B. t. Fleischnan, I.I 9an, 3. mold, J. 1»7S lancet H19H):100I-1016 OKI use) 10 01 o ------- flcarkoraa 7723-ia-o i in J0.9737C, m M.I c. B jga c, n 19 •• i« t 12? c (COETItOED) ussvt a 367 Bale • 36 Sidaar 4369 Llw XFOS01! ROOT* luimcit BET SOB n 11 •01 US OF C1SIS U 8 e» 12 at » W 9 c\| 11 11KS 1 t a) 25-390 q/1 hi 373-300 «g/9 fl 215-3310 ao/j a«t «t m) 606-3019 aq/9 b) (22-2315 09/9 c) 260-3600 og/5 •at «t (III •Ell \| eSBItll nrOIUTIOl 1 1 1 1 Bavta. 2 npraawitatl** I f ca— aaaliaia tractaaata aca 1 tabaUtad. Ika feasibility of a 1 Idllfltlc, ao-nak palter for hair 1 aaalyala l« eatlla«d aad sapportad. 1 1 mm: TSUI nmBts: Din: 1 IDSTBaLTa: BUSVBEIEK BET1ODS: I eftus; FMTCTS', COBFIUTITC 1 iiiioiTioBS: uonn; IBTIBOBI; 1 ISSEBIC; Blind; nOBTBE; C1MIOH; i cuciuB: cnenBi: cBionoi; COBIH; l ccppM; eiiina: esBiiinoB: COLD: l lemiu 1101 j LunuTOBj mo; 1 B16BESIII: B1M1ISSE: SEECOBT; \ tctrmDinB: ncin: THostBoiQS; 1 {CTJ3SIW: 10BIDIOB: SBXinOB; 1 SIIICOB; SILTEK: SODIBB; STBCWTMB; 1 sotroi: ti»: TTTHIBB; TOIGSTIII 1 TIIC; HBCOBHTI 1 1 a) 829 »q/g 1 at Coatcola b) 1157 nj/f \| b) Berkac I e) 12 £9 ag/g 1 c» torkat qreap n •«t «t \| leiliu \| caoaasai Mflaery aid saaltac 1 aotkaca, aq«a 5S-76 yr, crpoaad to 1 kaar aatal« 1-3 4aea4«a. Tla* 1 batavam tatitmaat a»4 tactk 0-1. S }t I la icoap I aad 2-19 re, Itott II. I ccatrol, a<)«» «3-72 yr, ako U«l SO 1 ta fcoa tb« factory. sad«>. 1 1 SflOBB; Claims; HDinS; llTBBi l Hies; coBfiiHiTE snmTiois: t ntasTBiii H6II11: msmcBim 1 BIT BODS; lITlBOtT: IBStllC; CIDBIIB: 1 ctsm: CBKISIIJB; coBitt; COFIE; 1 GCIO: IIOC IlRItBOB: HID; 1 BIB61IESE; BRCOIT; BOtlBIlBITS: 1 ciamnias; IOBIDIOB: SCIBDIDB: 1 SIIIBTVl: SIITEB: TIB; TOISSTEB; i 1ITC: BSalTB BalllBS: IBDVSmn 1 (iins: SBiiTfflj; Tsuinivi 1 1 a) 1876 «g/g I a) Coatcola b) »10 «j/9 1 B) Mtkac group I e) 1S2« ag/9 t c) lortar qtoap n Bat «t \| Badlaaa \| cacaaaal raf laacr aaA aaaltac 1 aotk«ca. iqaa 55- 76 yt, axpoMl to 1 kaarr avtala 1-3 4aea9a«. Tlaa I t«tM«a ratlraaaat »4 Oaatk 0-1.5 fc 1 1m group I aid 2-19 yr. groap It. 1 Ccatrols. «g«a 3-72 yr, ko Unl SO 1 tt {TOB tka factorr. Saaflaa. i stiBE; cioMMS; Kirans: imi; 1 10BSS; COBP111TITE XT1101TIOBS; 1 IIOOSTEI11 ilOIIBE; VSlSOBEinT 1 B1TSODSJ iniBOtlj HSniCi ClDIKtB; l CISIHB: cRBoranc coani: corpus 1 SOLO: HOB; 11BTB1BOB; tMD: 1 ii»ciwst: BiictjiTs MtTBDinm: 1 (lOSfBosvs: EOTIDIOB: ackisira; 1 siiifin: snrts; in: IOBSSIEB; 1 tlBC! BEtLTB BU1SOS: IfDOStllU 1 fllBTS; 3BHTEBSI TEUVIIOB 1 C f>61) BEFBBEICE Cbittlcboroagh. a. 980 Seianoa of tk« Total BTlroBieat 14:53-75 Brnn«, V. Bordbaro.« Q. feat«c« V.Q. 1990 sci«ca of the total E»lrt>BaBt 16:13-35 Broaa. D. Bordbacq. G. Faster, ?.c. 1990 Selaaoa of the Total Eavlnuatt 16:13-35 N) tn ------- Ikospkoras 1723-1»-0 t tt« 30.9737C, IP M.I C, BP 280 C, vp 10 » Ig at 127 C (COBtllTOD} TISSOS «370 Inng 371 Brine 1 EIPOSOIS BOUT: lagestion » MI men. BETHOD 11 . Chen BOBBES OF CASES a) 8 b) 9 0 11 10 BIKE a) 38»-2«21 ag/g fe) 67«-3516 ng/g c) 1«(-98« ag/g Wet rt lot given I mi a) 777 ag/g b> 898 ug/g c) 799 og/g Ret vt ledians 0.69 » or - 0.1* g/day etIEUl IIPOSEITIOB a) controls b\| torkec gronp I c) Vorker grovp XI Cecensel refinery and sselter lorkera, ages 55-76 yr, exposed to keavy aetals 1-3 decades. Tine retveen retirenent and death 0-1.5 yr in gronp I and 2-19 yr, group II. Controls. ag«s 3-72 yr. vho lived SO ka fron tke factory. Sveden. SIBDBH: ciDifEBS: Kioisys; IITES; IBBSSs COBPiBaTITB mLDlTXOIS; IIBOSTSI11 BTGIEBE: lOiSOBBBDIT BETioDS; inxniy; IBSSBXC: CIDMIBH; CIStffB; CBBOBIDB; COEUT; COPPE1; (OLD; IIOB; ItBTMBim; IE1D; BIBGIIESB; BBSCOBT: BOLIBDEBHB; fK)SPttO«9S: 61TBIDHJB: SCIBOXOB: SfLEIlng; SIIfH; TIB; TDBGSTCT: TIIC; BUITB B1Z1BOS; IIDOSTBIll Pit ITS; SiBLTEBSi TEUnXDB less after daily intake of 1.3 * or - 0.28 g. Data fron 7 7-day experinental periods. University stadents and enployees, a avrse and a teacker. Balliparovs. ages 19-29 yr. Fkospkoras talance slightly positive. reflecting adeqaate intake. IHEESSE: OBiiE: iioi: ciiciim: ilCIESIIg; RIIBBILS; PBOSPHOBdS; CIETS; IXIZBlt BITIBCLISB; PBESI1ICT I 1 EERBNCE Brane. 9. Bordberg, 6. Vester, P.O. 1980 science of the Total Environsent 16:13-35 (she, J.E. Sckotteld, r.l. Gran. 8.8. tnecican Journal of Clinical Intrition 32:286-291 1 1 K> <_n N3 Iktkalie acid, bla(2-«tkrlbezrlt ester (8 CI) 1.2-Benzenedicarboxrlic acid. bla(2-ethrlkezTl) ester (9 CE) 117-81-7 C2-B3B-O I« 390.5* TISSOS • 372 Idlpose «373 Spleen IXPOSITBE BOOTE 1I1LTTIC11 IETROO t 1 BOUSES OF C1SES BalG! BE1I SEIEU1 IIPOSUTIOI Beview of effects oa biological systess with enpkasis on safety CTalnation aad levels encountered in aedical devices iriwsi TTSSOE: spun; BSTII«; IBTHLIC iciDS: reriBouss; nitBOLIIES tevie* of effects on biological ststens vltk eapkasls on safety evaluation anfl levels encoaatered in aedical devices ttltOSE TISSUE; SPLEtl; BEVIZV; tmuic tens; BSTIBOLISH: mnOLTtis EETEBEBCZ Thoaas. J.I. Darby, T.O. Kallin, B.F. Garvin, P.J. Hartis, L. 1978 Toxicology and Ipplied Pkarnacology S: 1-27 Tkonas, J.i. Darby. T.D. •allin. B.r. Garvin. P.J. Hart Is, I. 1978 toxicology and Ipplied Pkarnacology «S:1-27 ------- Ilatiaaa 740-0«-« Pt It* 195. Of, IP 1773.5 C. IP 3827 C. TP 1 u H« at 2600 C, 10 as 89 »t 290 C iissirs »37t HlpOM »37S BlOOl «376 Bair •377 Kidner BXPOSRSE BOITE aflinXCaL H ETHOS US us us us IVRBEt or CISES 0 83 . 283 10 suet lot aiTsa lot given ) lot git«n ] lot glvaa «J lot giian lot glraa lot glToa nn i SBiiui iiroBuraoi i IEFBBEICE 1 i i i I I 1 <1.3 ppb \| a) los lagalaa r«sld«a.ts \| Jotaaoi, D.B. I ». ? ppb \| ft) Occapatleaallf «xpottd \| PreToBt. l.J. ( \| Hilary, J.B. I latopalas, los Itgalas, 12-74 TI olds I Caaau. D.E. \| tit » 51 yt oU aok«r »ho »U«8 uA I BoMif«U. J.B. I fioc«ssd ft. Pi it Ottirio. \| H7S 1 \| IP1-&00/1-76-019, 235 \| tZTlLS; niTIIDI; PUUIim; t!U»J \| pp. t (QPOltnO IHOSV1B; OCC1»lTIOItt \| 1 gillBIS; CIUPOSIH; IDTOPSItS; \| 1 tlOOI; XI tills : SPLBZI; Bill; OSJiE; \| 1 ivies; mscus: impost TISSVB: i I inra; comiuTiTB miiatiois; IB* i 1 J1BS1T; Cllltl; milSl atROBOTITB \| i i I 1 a) <3.1 «g/100 mi [ a) los ia««l«s aad laacastn ( Johiwm, D.J. b) 0.09 aq/lOO ml I taai«««t«. laolTlaaal inn; CO«P»I»THI ininiuoas: m i I JtBSBTi CIIIC1: iniM; mOHOTITI \| i i I i <0.05 a?/g \| lot lioalcs lad Lancaster EMlOots I Johana, B.S. 1 I vc«ost. t.J. 1 Callforalaaa llTiaq ao«n»i»4 froa a 1 TUlar?, J.B. 1 (r«»ay 1> los iigclas or 1* tka klot 1 Caaaaa, O.e. 1 ats-art roctea of Lancalter. lq* I BosaafeU, J.e. 1 gtoaps; 1-61. 17-3. 35 or aot« TC> 1 17i 1 «0t «alt«. »W loa-ihlt« ia las \| BP1-«00/1-7C-019. 235 t laaalas. 80* vtita. JO'S aoa-«1iit« U I pp. 1 lageaator. I 1 1 1 tit us: IIIIHOB; riiiiMOB; IBID; r 1 (OPIUTtOI tXPOSVKZ: OCCHTMIO111 \| 1 UZaBES; CILirotlll; iDTOPSItS; \| 1 BtOOD; CIDKIS; SfllH; H1IBJ VHIB: 1 \| IOI6S; SDSCIES; 1DIP03! TISSUE: I \| IT1B1; COBTlMTln mWitlOIS; IB1 t I iiisBT; emu; inriia; HITOBOTITE t i t <2.« ppb \| tea molaa milnta \| jahasoa, D.B. 1 1 Frawst. t.J. I autopsies, 12-7» yr olas. 1 TiH«ry, J.B. 1 1 caaaan, D.B. 1 tnus: TimnB: PUIIIIOB; LBUI i nsoafeid, J.B. \| iOSOllTIOI tlPOSBK; OCCOPKIOail 1 1»7« 1 Bins is: cuirosiii; IVTOPSIBS; i tM-«oo/i-7«-o». 23$ t HOOD: titiiTS; snEBii BIIB: OBIIB: i pp. 1 iwesj aasciis; IDIPOSE nssoz; i \| tltt»; COHPalltlfB BntVltlOU; IBB 1 1 jt»BT: ciini; BniK; IOTOOOTITI i i i tint MGE) ' ------- ruttm 7WO-W-* Ft »M 15.09, I 1773.5 C. B* 3827 C. T» 1 «• »9 «t 2COO C. 10 •• 84 at 240 C tcorcmmi 1 1 1 1 ttsssi «J7t tl«r «37» t«« «3«0 B •Ot fiTU BMB i sBBitti imiiraoB I immcs ' i i <0.2« ppb \| Io» 1>91«* cai4mti \| Jaks«o>, ».«. 1 1 r«TO»t. S.J. I lltapiiM. 12-19 it old«. \| TillMf. J.B. 1 1 Camu, 9.B. I sntis; KJimi: »iu»m: t«»; t lowitcu, i.g. 1 rerramoi nrosni; OCCPPITIOMI j i»7« I IIM1C3I CIIIFOIIU; kITOFSIBSt > t?t-«00/1-7«-019, 235 1 HOOD! KIBMIS; SniH; Bill; UHII; \| pp. 1 idlest nsctts; UIKSI nssoi; t I inn; cotPtuTm inumois; tvi i I jetsrr; cuict; BIBIMI totontm i ) <1.3 ppb \| •) tos Ii9«l«i t««13«ta \| Jokiwom. B.S. ») 3.T ppb \| t\| Oec«p.tlo««llr •rpaOT4 \| tmemt, t.J. 1 1 Till try, J.B. I litop«l««. to* l««ln. 12-7» yr alts I Own, ».». I »a • 52 Tt eU rto ta«« ud I Boamtcld, J.B. 1 fioeMMt Ft, Fd i» Oxterie. 1 im ! mo., »«mi, F.UOI.B, lun ! »f-°fl/1-7<-ow- M5 t toinmoi nFosoii! occmiTioiti i I milts: cuiroinii inoFsiis; i 1 BIOODJ nntis; spttM: BIII: unrs; t \ tnss: iffsctcs: IDIFOSE Tissoi; i I Hint coRpmnrs zntnnois: 13 i I JHSBT; ciMct; lima; anoaotm i i i • i ,' «) <».» ppb \| > los 1>?«1<« n«t4«t> \| Jok.wi. D.B. b> 2S.O ppb 1 t) Oeeapatloully •zpowd I Pr.TMt, J.J. 1 I Till«j. J.B. 1 »ltop»l«8, m li^ilm, 12-79 ft olds I cum. B.E. t »d 22 TT old nokir ------- »t m.«9, 0 1773. S c. BP 3i27 C, TP 1 M Rg «t 2600 C, 10 •• Sg at 290 C (coniivio) nssn nn Vrln mosnu BOBtt iiumcii RBTBOD us mm at cms a) 213 b) < •MSB a) tot glim b) 0.23-2.58 ig/1 nu a) <0.6 «oyi b) LOT 09/1 6EIH1I I1TOI1UTIOI a) lo« lag«l«a aid la»ea«t«r zid«Bts 11 Oce«patlo»llT «xpowd CallteTBiaac li.Ti.Kj domviad from a fr««T !• los 19«1« or ii th« higk ItMrt cqlo> of lamca«t«c. kg* qrotp: 1-K, 17- 3», 35 ot mor« jr. COf «kit«. o< «m-«Ut* li lot U4«l«s. ««« Ut«, 20« UB-vhit IB I>ica«t«c. !•« JC<«T r«fi»«rr •ottir JITU3; H-ltlWH; fltUDIDl: LIU; to?nmoi nposmti occnettioiti •nuts: ciinoint; IOTOPSIIS; HOOD: ximiTS: snt»; BUI: ami: i»«st nscus: igitosi nssns; inn: comtuTin imautaist HI JIISIT; CtllDl: 8II1BS; IDTOIOTITS tmisicx Johaioi, 0.1. PrVTOBt, B.J. Tlll«cr> J-3. Caiun. 9.1. «OMBtU. J.B. 1«7« IPl-«00/1-7«-Ot9, 23S PP- PlubaM. cklorotrirtkyl- 1067-M-T e«-«is-ci-Pb • 324.9 1ISSDI «33 idrBal glaaft »3»« •loot •3«S IralB txposoiB tons 1ULT1ICM. BRBOD «8BES OF CiSES met - HIM etmii nroiamoi >6»: nsBis: POOD cotMHiuTioii rons: usoLin; enmc tmcrs; mvsniii icciDtns: imitRai: HBBH tstis *Ti«. ToiicaklMtlo aad to lie •ftcctB of ocgaaolBad coapoaBdv eirtBat occiiitloul and •BTlcoaBoBtal (ipoiit* data. •IITtO StlTIS; SVBOPt; IEW CietRIC cctKmiBS; imoBotm; in PcitmoB; <«iciiosti: ftsBis; FOOD com«m?ioi; runs; sisoini; entile iincn; WDUSTSIII iccieiirsi iHuinov; UIBII uiu Kria. ToxleoklBotles aad toilc •tfocti of otqaaolcad eoapoaads, e«tr>t ocetfatloaal aid •artragMirtal KBOBBC* dta. eiltlt STITtS: EIBOPI; USD CB61RC coiFOTiDS; amoRoiiTB: in PCIIOTIOB; ciiciKaii; nsBis; TOOD COITlRIIHIOfi TOESS; 51SO1IIB: cnrrrc CPTICTS: noDsnui icetgiRS; tmunois isti IBEIS t tirBIEICI GzandjaaBi p. IlclMl, T. 1979 Kealda* Barivwa 22S97-1M ecaaljoan. f. IlslMi, I. 1979 ItBSldW S«ll«»S 22:97-1** GzaBdfcaa. p. Uelaea, T. 197» s«si.4m BBTlwis 22:97-11 (HIT pun Ul (Jl ------- 1«7-1-7 C6-B15-C1-M «I 329.1 Ccomvtm) TISSUE «3«6 B««rt »387 «3I8 4390 •aacccas «391 I EIPOSBBE BOUT immcii. IITBOP rrasn or c»sss BUGS m> i 6MI1U xmtiiTxei i EEHSEBCE i f i l 1 Mvlo. ToxicokiMtica- and toxic 1 GraadlaaB. P. 1 «f facts of orgaaoload coapoonds, \| Bi«lMB, T. 1 cort«Bt occvcatioaal aad I 1979 1 €BTirOBB«Btal xponr« data. t B«sU«« BT!««B 1 1 22S97-1U I IBI1IO ST1TH; ITOOPB; LI1B CBGMIC t 1 CCBPOVflS: IROBOTIVE: III PCLIKXOB; \| l CHCIBOSH: USB; torn i \| CCRlBIBinOB; T«BXS; 61SOIIBE: 1 l SIBRIC tiptcxs; IIODSTBIU i l icciDEBTS: iwiiMiati trsBtf IBHS i i i 1 i 1 Bavie. Toxieokiaatiea and toxic t 6raadj«u. P. 1 affects of orgtooUad coapoaala. \| litlatc, t. 1 cgtrut ocncatioaal and \| 1979 1 " 1 22:97- 1M 1 oimg sTiTis; sraopt; tew nsanc i 1 COBPOmSS; iniOSOTITE: III PCIIRIOB; I t CISCIBOBIU fMIIS: fOOD \| 1 COBIIBIB»IIO«: VmtS; S1SO1IIB; I I eiBtric crrscTS; mosisiu i l iccxpnrs: iraitiTxai: nati IBUS i i i 1 l«»ie». Toxieoklactle* aad toxic 1 CrudTaaa, P. 1 •tf«eta of orouolMd oovpooads. \| Bialaam, T. 1 cirtmt eccafatioaal aad I 1979 1 atiroaa«tI •xposace data. \| P«»ia«« g«ri«r* ( 1 22:97-18 1 BBTTXD 1T1IIS; EOBOPI; »AD CJSMIC I 1 CC9POOVBS; lUTOHOTITB: 111 POllVTIOB: \| 1 CIBCIBDSK; flSBES; FOOD \| 1 CCBTIHMTIOB; THUS; eiSOIIBZ; \| 1 CIBRIC SriBCTS: IBODSniU I 1 iccnrars: IBBIUTIOB; TOBIB IBIIS i i i i i I !•!•. Toxicokiaetica aad toxic I Graadjaaa, P. 1 aifacta of otvaaolmd ooapoaads. I Bielaaa. t. 1 citnat cceicatloaal aad 1 1979 1 »«Tlro»B«0tal oxposat data. I Pesidne Sawieas 1 t 22397-1W \| VBXRI SIIIIS: EOBOPB: 1113 CIGIBIC I 1 ccBpcrais; ittoRcnrs: ax* rcivmoi; » l CHCiiosm: IXSBES; POOD i l coBTiixiiTiOB: raiss: eisoim; i 1 CIBRIC inters-. IBBOSTIIU i l iccxonrs; IIBIUTIO»: OBBM IBIIS i i i 1 l I !€!•>. toxicoklMtica aad toxic I Grand 1«aa, p. 1 ff«ets of onjaBol«ad coaponada, I Heist t, T. 1 corrent cecacationtl »d I 1979 1 tiTlroBMBtal •xpomca data. I Besldaa B«ris»a 1 1 22:97-18 1 OBITED suns.- tmort; IEU cseinc i l ccBpcgBos: amoBtmtx; us paimioB: i \| CISCIBOSIB; TISBIS: POOD \| I ccBTiiiuTioi: rnns: eisaxiR; i 1 sunic srrecrs; IIBDSTSUI i 1 iccntRS: iBBtunai; OBBH IB us i i i 1 l " i ««»ie». Toxlcoklactics aad toxic 1 eraadjoaa, P. I affacts ot oigaaolaad coapoaats. t BlelMa. 1. t c«rr«t eccatational aad I 1979 t «niroBa«Btal vxposnr data. 1 Casidne S«rie»s t 1 22:97- 1»» 1 tiBTno sTiits; IBBOPE: LIID CXCIBXC i 1 CCBfOVBOS; IVTOBOIXTt; KB PC1HJTIOB: \| t OBCIBOSIB: IISBE5; MO9 I I ccBTMiiiaTiOB: rnns; cisotnt: i l eiiRic inccis: IIBUSTSIII i \| ICCIfiinS; 11S11ATIOB; OTBH 1511S \| ' - t ------- eklo»trli«tkrl- •1 287.77 tissm •392 Drln BIMSDtl lOtRC itiimcii BETROD iraitt OF C1SSS UMH BSlB . - eniui xtroBBiTiai («!•«. 1axicoki«tie »»4 toxic tlfccts of orgaaotead coipouda. decent oeemcatlaul ml (ETicoiMitil eiponr data. tlTTZD 3TITI5; 101OK; IZ1D CBOHIC coBEOtmos: IBTOHOTITB; in raionoi: CIKttOGtl; TI58K; MOD ccntBiiMioi; rons; cisaini: eiimc ti tiers; iiovmiu. ICCIDMIS; IIBIIITIOI; 5BB»Ji 1BU3 BITHEIC! Ciaaajui, t. li«lMD, 1. 1»7» K»llie E«tl«»» 22s 9 7- 1S , t«tr>«tkrl- 78-00-2 CI-BIO-Pb g« 3Z3. »5. 4? 125-150 c, BP approi 200 C, TF 1 m Bg at 3«.» C tiasai •»3 11004 139 Btla» nrasmc EOTTI UllTTIClI. BITIOO •TIBBn 1 or cisss SU61 mil Sttllll 1IFOIB1T10» \| 1 1 •cftn. ToxloaklMtles aad toxic •fleets of orgaaolaal cocponds. cictvat occafatiooal and ««Tlroi««tl •xposat* data. 0»I1« SUTtS; fOton; UU CB6MIC ccipotuss; unoaoTUB: in PCLIOTXOI; CIBCIIOS1I; flSHBSS IQQD coiT»ii»»Tioi; rums; GISOIIBX; EIItTIC XIItCTS: IIDOSTBI11 ICCIDIMS; nauiTioi: nsaii tiiu f«vi«v. Toxicokiaetics and toxic •tCcets of ocfaaolvad coaiiott»S«. cocreot occafatioaal a»d • evicoaMatal eipoavre data. DIIIID suns: ztnoPE; iziv CRGIIIC COBfOIJlDS; imoBOTITB; UK PCU.DTIOH: ciBcnosH: lisa is; FOOD cciriBi!HTio»: tans; eisotnx: GIIITIC tillers: noosmii 1CCIBMTS: IIBltlTIOI; VBBtl 11US tXTEBZICB CC&aijcD, f . nielMB. T. 1»7» gcsidie S«Tl«a 22:97-U8 Grand jeaa, T. HUlMIL, 1. H7» Kealdae B«rl»s 2S:»7-1«8 Ln ------- Tolybronlnated biphenyls (Bo postings i» CBiniR). TISSBt »39S Blood «39« Blood, plan 4397 ood. sens ETPOSB1E WOT gestlon imrticit MTBOD 8C/BS 6C/BS 6C-EC BOB an i sites OF C1S3S \| 1 21 I a) 1.1-57.3 tg/mg prot« I b) 0.03-0. CT »g/sg I protein 1 c) 224-282 ng/eg prot«i 1 4) lot detected I I I I 1 1 1 • 1 1 1 1 1 1 t 1 1 1 21 \| a) 0.13-10.2 ng/ng 1 protein 1 b) Wot detected 1 1 1 1 1 1 1 1 1 1 1 1 \| 1 1 290 I a) lot given 1 b) lot given 1 c) lot given 1 d) lot given I e) lot given 1 f) lot given 1 g) lot given 1 h) lot give* 1 1 1 1 1 1 1 1 1 1 1 1 1 I \| 1 1 1 » nil i ciniu IIFOBIITXOI I t a) 23.75 ng/ng 1 a) leukocytes. » exposed chenical protein 1 icrkers b) 0.35 ng/ng protein I k) Brythrocytes. » expos! cheeical c) 253 ng/ng protein \| workers d) lot detected I c) Beta-lipofroteln fractioa, 2 j «xpoeed ckeeieal workers 1 d) Leukocytes or erythrocytes, W \| csbjeets. including ezpoMd dairy 1 farn residents and controls. 1 1 Bichigaa ckenical workers and dairy j fare residents exposed to Firenaster j IF-C. Controls, dairy far residents j ie liseonsin. 1 I Stimulation dysfnnetioB of j lynphocytsl tested ith \| rkytohenagglitiBin and pokeeeed I nitogen, especially in the * exposed 1 ekeiieal verkers. 1 \| ICITBJO1II1TID BIPISITLS; 1 IlTtnOCTTIS; BLOOD niSHl; I IIOKOCTTIS; HCHieil; IIDOSTtTIL \| IlirtS; IIDDSTBI11 ICTOSPHEBISi \| IIDCSTKI11 DISE1SSS: IISCOISII I 1 a) S. 1* ng/ng protein \| a) 4 exposed ckenical workers b) lot detected I e) 18 sab-fects. laclwdiag exposed I dairy fare residents and controls 1 I Blckigan cheiical workers aad dairy 1 farn residents exposed to rirenaster 1 EP-6. Coatrcls* dairy fars residents I In llceonsln. 1 I Stinlatlon dysfnnctlon of I lyapnocytes, tested with j piytoheingglatinln and pokeweed j eitogen. especially in the * exposed 1 ekenical workers. 1 \| fClTBiOIIMTID BIPB1IT1S: \| UTTnoCTTcS; B100B FLlSBt; \| IIDROCTTIS: mCHIGll; IIDOSTIIIL 1 Fiins; iiDosrstai ITBOSPBEIFS; \| IICOSTBIll DISB1S1S; WISCOISIW 1 1 4.23 ppb I •! 1» sales 2.72 ppb I t) 1(3 fenales 2.75 ppb \| c) 0-« yr of age, 33 soblects 7.08 ppb 1 d) 5-8 yr old sales. »0 snblects a. 32 ppb \| e) 5-8 yr old fenales, 37 sablects 3. 18 ppb I f) 9-12 yr cf age, 81 subjects 3.»5 ppb f g) 13-16 yr old nales, 59 subjects 1.87 ppb t h) 13-16 yr old feeales, «3 subjects 1 1 lleklgan children living on 1 Pie-contaninited fans or children 1 censoeiag neat or nilk froe these t fares. 1 1 lo significant association of 1 atnoraallties and seres PBB levels. 1 Significant negative correlation 1 tetween Hunter of reported synptons 1 aid oer«n PBI. 1 I FCITItCHIKlTlD IIPHBniS; B1OOD 1 si80«: CHn»in: ncwietii: nscoisii; \| TCtD COB1»1IHIOB; 1IIH11 1 tOPDHTIOlS; TUBS; COBFllVIIVB \| miUlltOIS; BtOIIIB 01111 1C \| CCBIO019S: Sit; X6B: BlaltB BIX1B9S; I tins i UriBEICB BobOI, J. Snznkl, B.X. Bexesi, J.E. Bolland, J.F. 1980 Journal of Bnvironnental Pathology and Toxicology 3:3«3-37i Boboz. J. Suzuki. B.K. Bekesl. J.6. Holland, J.F. 1980 Journal of Eavlroueatal Pathology and Toxicology 3:33-378 Barr, R., Jr. 1980 Environnental Se search 21:255-27* N3 Ln 00 ------- relrferoalaatad l»o peti»9» la (cotnimo) IHSM •3M •Ilk •HOSm MDTC 1M1TTIC1I IJTBOD mm or CISBS UKI m» CEIfUt IIFOBBITIOI _ l«iv of Mr«aaat«r coattalntioB ef cattl* e««d la Bickiga» ul T«eon«4tiau for anslag lotlwra jipii: ignis; Hurts; ssn Bisiisis: ntxr imn: fOlinOinillD BIPHMTIS: tCIYCHlOMIllIB BIPBWTLS: iioiccomiiio; mi iiriisins; iocs coniuuTioi; rooos; LICTITIOI; pofjiiTioi inosvn unmet Rilltr, I.«. Tinb«rg, 1. 1ST7 Jonnl at Pediatrics 0 (3) -.510-512 . tetwslM 1» I c. 100 M sg »t wo c TISSVZ •39 Hood. aartta a»09 Iraata aalr nosou SOBTE Inhalatlaa IHLTTICIJ. BBl'BOD US mi us •BSSSS or cisis «1 2«0 b) 260 1 a) 31 b) 22 11TCS a) lot gl»«» b) lot gl»«« - lot glaa a) lot alvaa b) lot glan mi a) a. 11 » or - 0.05 M^/l bl .32 + ot - 0.03 aaq/1 10S.O ng a) 1359 ppa b) 12W ppa GEIIttl mOSIlTXOI at taaaa* city, IS. krd-aat«r am b) Kaasaa City, to', aoft-vatcr ana IS and HO raaldaata aatch«d for aq« laeaa aq«a 37 and 37.7 re) . aex. laaqtk of caaidaaca. aarltal ana «eoaoalc atatu. occapatlon, aaabar of eklldcaa, aaoklag kablta, it, »t. la bard vatac araa, algaitlcaat leeraasa la fcTB«ttaaaleD. TCS ataoraalltlaa. aad krpcrnrlcaaia. I1IS1S; dlSSCVBI: 1DOLTS; cijtiOTiscniit gissisis; BtPISIEISIOl; BLOOD SBBUB: CCBHSlTtTl miOHIOIS; C1D8HS: CHCI09; CBBoaina: LITHIDB; tienstnt; nosrsnsoos: POIISSIOB; SCMDS; tllC: SlOUCCtrauHTIOl; tlllKIIS 1HIB ( 1 saaplad at rat of 1 1/aln, 2-10 ala aftat bnralag * arc vaiaiaq rods. DilTcrsltr pkyalca shop, Tlorlda Tionot; linns; Bi»TB: cucins; cno>n«: cnomB: CCP»I»; IBOI; HID: aiieiiisE: ncm: foiissiim: SOlTIl; fnillOi; T»1BI1!I: II »C; 118 oimto«: FOBIS; iievsmu itMsrann; tiici nirairs t\| Coatrolt laanisg dlsaalad and aerial 3rd aid «tb grada atadaata la Caaada. citcnu MSBSins: roussina; SCCHJB; CUJBTOB; COB11T; COPPER; isci: ism: uicmsz: ziic; cncBinx; LiTHina; uncogT; sntis-. nit: cnxtDizi: ciiiDi 1BTIRE1CS Blaraabaaa. H. I. Tleisctiaa, I.I Icnold.'j. 1975 lancat 1(19ia) :1008-1016 •kselxzon, K.E. Desaedelevc, E.G. Johaasaov. T.B. »ioc»e»ter, J. «. 197« laaals of Occupational IT?1«« 19:225-238 Pihl, 1.0. 1977 seine i»a(a3i3i:20-20t (HIT MSI) NJ Ul VO ------- Potassina 7MO-09-7 K >t 39.096, HP 63.2 C, BP 765.5 C, Tt 100 mm Bg at 590 C (COBYIBVED) TISSUE M02 Bair >>03 Heart Ezposvn Boon 1BU.THCU HITBOD Plaae photometry BOBBEI OF CASES al « b) 7 BAEGE a) 0.035-0.086 mSq/g b) 0.068-0.082 iZ9/a let »t BUI a) 0.063 * or - 0.013 aEg/9 b) 0.07* » or - 0.006 aSq/g let >t 61BI1U IIFOEB1IIOI l«rl>. 2« t«pr«sentatiT« Ft«-aaalysia tr«at>«nts arc tabilat«4. Ike feasibility of a tollatic, no-»«s» policy foe kair analysis is out lined and sapporteij. flTII; TB»CI BIMSITS; BUB: ItSTBiLIl; niSUBMZBT SBTBODS: CIT1LS: PEOTZIBS; COIPIBlTIfZ ETlinniOBS; 110BHOS; MIIHOIT; ISSIIIC; BIBIUB; BIOB1IB; CIDRIDH: C11CIDB; CnCRHBi CnOBIDB; COBilT; CCFPIB: 3111IUH; GBIB1BIOB; COLD: IOBIIE; IBOI: HBTBlBtlH: LUC: SIGSISIOB; IUS1IESB: BBKCDRT; cciTBomi; imn: PBOSPHOBDS; pcTissran; SUSIDI09; sBtzBim: siiicoi: sjiTKB; SOOIDR; STBcnivB: sniroB: TII; TITIIIDB; TOIESIBI; ?i«c; zncointB a) Sxlden death fros ischeiic heart aiaease t) Sullen oeath fro« ttaaia Veatcicalar ayocardiva < 60 TC olds B1GIBSIOB: POTISSHJB; BZ1B1 EIS.B1SBS: tiropsizs; BfisT: imis I lirlBBICZ t Chittleboioagh, S. 1980 Science of the total taTlroiMat 14:53-75 JohasoBr C.J. Peterson, D.8. Ssitk. Z.K. 1979 laericaa Joornal of Clinical latrition 32:967-970 Piopaae 7«-98-« C3-H8 SB at. 09, BP -189.69 C, BP -«2.1 C, TP 100 •• Eg at -79.6 C TISSUE MMAk Breath EIPOS02B ftODTZ illLTTIClL HETBOO OC/HS VORBEB OF CASSS _ BUGS Vot detected— 2. 2 noXbr (BAB 0 8 Qd/hr GPItlll IirOBBlTIOB •etabolias. Bo other details giYea Cryogenic saipllig techBlqoe. Bealthy eilitarr and civilian eaployees, n.S. air force School of l«rospae« Bedieii, aaes 23-7 yr. 3 stokers. tlBZBUBS; CBIOTIHTBC 9TDEOC1BBOIS: CBIOKtn OI6IBTC COBPOOSDS: CBIOBOBSBZZBZS; naOBIBE COBPOOIDS; III1TB; 1ICCBO1S; THIS; » DOITS BZnBZBCS Conkle J.P. Caap, B.J. Sslch, S.Z. 1975 Archives of Environmental Health 30 (2): 290-295 ------- fropaae, 2-aitro- CJ-I7-B-02 H 89,09, BP 170 C, TP TO •• Bg at IS. 8 C IMSOB sao; Breath BTPOSBBB BOBTB iiiiTTicit KTTOD SC-BS Of C1SBS S« (37 staples) MBSI lot qlrea • mi O.aos nq/1 Seoaetric eiitUL urasRitioi Masacad at 25 C aad 760 aa Bq 11.1V occvrraac loer aid upper oae-SlqM Halts 0.111 ud 1.3* ftoyi laaltkr. t8-JS yr old. noaaMklaq, artan blacks and Caucasians. Cbicauo, II. Ilqldlr coattolleft «Dcriae«tal eoadltloas. CB1CBIIITBB BTDBOC1BBOIS; TOliTILE* cesmc coBtcnos; HBJLHE HKIEBS-. HHiUTIOl: 5BT1IOLISB: BETlEOlItES: popirnTioi iiposintB: OBB»« IBEIS EEIEBUCB KrotoazTnski, B.K. Brnaaav^ G. R. O'ReUl, B.J. 1979 Jotmial of Analytical Toxicoloqi it 225- 23% Proplonie aclj. 3-aaceapto-, etkyl aster (S CI) l£op«BOle acid. 3-iorcapto-, etk^l eater (9 CI) :t«6-06-l e«-aio-o?-s ni 13.21 TISSOB aao« Braatk BXCOSIIB BO1RB alULTTXCaL Hit BOD SC-BS MBBBES OF ClSSS W (317 samples) ttlEI lot given Ull I 5.3 m/i Geoietrlc SIieBlL IITO1H»I01 reaanred at 25 C ud 760 aa Bq 21.2 occacrence Lower aad apper oaeslqia llilta 2,S aid 11.2 9Vl aealtkr, 1S-35 re old. vonsaoktaq. at tan blacka ud cancaaians. CUcaqo. II. ElgldlT co»troll«l •ipcrlaeital eoadltioia. IBUTB; ElCCBOLS; 1111 IO1S; 1DQ1T5; Ctla»IliTlg BTOlOCaSBOIS; TO1ITHB CtSllIC CQItOQIDS: SB11TH B»HB5S; iisiUTtci: nmoiisH: BITIBOLITES: (O;HUTIOI BIPOSIBB: HEBII HE us SMIBISCB ' \| Frotasiynaki, S.K. Bconeaa, C.a. O'weill, H.J. 197 Joacaal of laalrtleal Toilcol<31 3: 223- 23 iroplophmoae (8 CI1 1-PTOpa>o«e, 1-phanyl- {9 CI) S3-55-9 M-H10-0 B« 13«.2, RP 21 C, BP 218.0 C. TP 1 a* ft? at 50.0 C MSSUE MOT Breath ziposim BOUTS ifumcii. BETBOD GC-BS IDS BIB OF CASKS 5« (387 euples) EIIGB Vot givea REII 0.261 ng/1 Geoaetric GEHBIL nfOMUIOl Beamced at 25 C aad 760 aa IKj 2.a« occ«ct«Dce lever aad neper oae'Sigia Hilts 0.05 ad 1.1» nq/1 BcaltkT. IS- 35 it old. nonsaoklnq. actan blacks aid caacaaiaaa. Chicago, 11. Biqidlr coatcolled HIKB-, IICCBOLS; IlltjoiS-. iOULTS; CB1OBI»»TID ETB50C4BBOIS; TOltllLS CECinc COIfCnDS; SMITH BlIiBDS; 1IBIIKICI; SETJKL1S1: BET1BOLITES: ECPfltlTIOf 1IPOSUBE: 18BH IBflS fiZTBBZICB KrotorryasXi, B.K. Bmnaaa, G.I. o>Welll, B. J. W9 Jouraal of analytical Tozicology J-.225-23 ------- »lcohol (8 CIt 1-tcopMOl (» CI\| TV23-» C3-«»-0 « «0.1, W -117 C. OT 97.19 C. n 10 M t lit W.7 C tissrrt Bnatk 09 BCMtk HIPO50IS xore imrrtoi »mo» ec/ss SC-BS IVBBEt OF ClStS S ...... S» (387 iliei lot d«t«ct«4- 1400.0 ««/kr lot glTa •Ell 175. « «j/kr 21.1 »«/! MOM trie BEIIUt Xiromiioi CecpoHd related to oorial Mtabolln. la other detail* aim cryogenic saipllBa tecktiqve. •eeltfcT allitarT Aad cirillav *plOfn, t.S. Hi rorc. school of Krorptc* KllclB. ?•» 23-7 jr. 3 sak«. Btnns; cnatiHTiE BTDIOCUBOIS: cnoinv oteinc COSPOBIDS,- CBiOMinznis: ruoun COIEOORSS: E1IITB: ItCOBOlSt TIUS: 1D01TS !»•««! »t 25 C MJ 7«0 n aa 50. Jt oce«rr«e« tCMT Ml IppW OU-SlgM lllltl 3.9 ail 11. 1 »q/l B»althy, 18-35 TC oil. ooBiMklK;. vxt<* blAcks ud Cftcotflua. Cklcaao. IL. llgldlr coattJllod • iporlMitil onaitlooB. MIITB; JUCCBOIS; IU.HOIS; 1DDWS; CBIOIIUTZD EniDClIBOIS; fOllTIl! cusirrc COBPCITWBJ: asirrs BIZISDS; IHUIIIOI; IET1J01ISB; M»BOimS; POPOIIIIOB ttPOSVEB; 1SB1I ISStS tERSEICE Covkl. J.P. c«»p, B.J. Mick. B.I. 197S VBTicoBBental Maltk 30 (2) 5 290-295 rcotamrMki. B.X. Iramtc, S.3. O'Mlll, S.J. Joirtil of lutytlcal Toxieoloaf 3:225-23* Prapria (• Cl) l-Pro»T»« (S CI\| T«-99-7 CJ-»« •i 40. »s. nr -10* c. tf -23.3 c, 387C •• 19 «t 20 c TtSSBI BTMtk Etpajots lomi 1 iiitrticit •ZTHOD ec/HS fVBBES OF C1SSS 8 MKE lot 4«tct«d-2.3 mf/kr W»I 1 GIltllL IIFOK111IOI t 1 I O.S «g/kr ( CCF««I] c«lit«A to nonsl 1 Mtabollsi. lo ot»t tetill 5lT»» 1 Ccyaqvalc mpllaq teclniqn. \| 1 B«tltkT Illitur ud clTlllu 1 «plOT««», 0.5. tic P»c« School of { l«rop«e« ftdleln, tgn 23-7 jr. 3 1 1 mints: ciiotimm miocitaois; I cnosm omnc coipanvs; I cnoBotmtns: nvoan coRpogim; i mirs; ticcioLS: TRIS; IBOITS i uniEin Coakl. J.]>, C««p, 3.J. «lck, B.E. 1975 IccklTci of 30 (Z): 290-295 ------- llfcldiai fb It «S.««7«, IP 39 C, «P <•• C, n 10 mm B? at 3»0 C 1ISSV1 Mil Braia »»« , lair Mil ••met RIOStltl tOOTI aMITTXCU RETROD n n »n»BEt or cure •t 7 b\| 3 MICE \| Bill \| GtiniL motlatlOI t 1 < 1 1 1 1.6-4.6 »9/9 (nt «t) I »1 3.0 » or - 1.2 I a) laics, ctbru, 6 mblacts 1.«-2.« «j/9 (»«t «t) \| ao/g f«at »t) \| t) F«ialB, c«r«brn, 3 «t »tl I b\| 2.3 « or - O.M 1 c\| Bal««, c«c«b«U». S nbjecta 1.1-3.* «j/g (nt «t\| \| uf/g <««t it) I 4\| F«aala>. oanbellaa, * aabj«cts \|c\| 2.3 * or - 0.3 1 I «9/9 {»« t) 1 Tcoi a qcoip of 1 a«topsi«i, \| d\| 2.6 * or - 1.0 I fonacte n«lcal ezalBatloi«, Japan. 1 »9/9 (««t »t> I ••!•>. naa 19 10. t ji. r«ul«s. 1 \| a«ai ai« 37. < yr. 1 1 1 i TSICI niRtiTSi » BIOPSIES: jwii: 1 i itniitus; aisnic: cunos; COSU.T-. 1 i cctoixm; ccipn; iio»: aitcrai; 1 i ncigi: iieitsioi: lueinsz: I i iranm: iinnoir; SCMDIVI; 1 i snni»t Titimi: finoina: IIK; 1 i sciB: noviitt lira: KIDIIIS; 1 \| CIBMB89; CMtSBllDII: IBlEt; HOSCLES: 1 I «UOtIMl Slim: tOKS; 1OIT1: 1 \| IR1LS; COIPUKITB STU01TI01S; SK; I \| ICBIISIC RSIICIIE 1 1 1 1 1 1 MTiwt. 2» npc>nta«iT« 1 I ir«-nalfili tratamta ac< 1 4 tahml»t«4. Ik* faaslbilit? of a 1 1 lollstlc. >o«aaa policr tec hair 1 1 aaalTaia it emtll»«a aid ««it«ct«i. 1 1 I i mm: mici nmirs; HHJ, l i usriiin: magunn IETBODS: 1 i CITU.S; pwmiis: CCHUMITITI 1 i iiiwiTiois-. uvinm; uriMit; 1 i aisnic; niioa: Bioain; ciMim: l i cuctoi; cticciH: cnoaiOH; coetLT: 1 i cettes] ettmn: SIBBIITTIB; SOLD: l i icBtni 1101: iimanra: i»i: t 1 H1SIBSIOI: BII3I18SI; mCUIT; l i ICITBOIIVIS nciiL: PMSFHOSUS: < 1 COIUSNtCl SraillH; SILWOT: I i «ttico«: sntit; sotnt; siieinva; 1 l sutrns; Tin imntn; tvi«srn; 1 l tiic: SIICOIIVR • i I t •) 1.2-8.1 «g/« («t t) \| a) 3.» « or - 2.2 1 a) ial«< b) 1.I-2.H q/l (»«t «t> \| » \| t) Mal« 1 bt 2. 1 » or - 0.1 \| 1 aq/4 (>t »t) \| fcoa a qro«t at 1 a«top«t«. 1 1 fot«a«lc Kdlcal •zailaatloM, Japan. 1 1 lain, Mai «qe «0.« it. r; COBU.T; i i cBiQun-i-, cemi; noi; Hucnt; 1 i iimn"!: auitsiOB: »ien»t; l i tocTDni; miBon: scinoioa; l i sntiioa? tRinoi: T»«BI«I; me; i i SCLD: BMBIIII iirai neitrs; 1 i cifwn»5 ciiracun: HUT; BDSCIES; l i P net sis: sfttti: latest lorta; l i untLS: coiimtm naimiiois; sti; i i music aioicxn i i (HIT PlOE) raiEncz Tikaoa, H. Sgzaki'Tanioto, a. laaao, K. Terai, 8. 1««0 IrcblTM of CBTlconMital Health 35(1):36-a« Chlttl«bocoagli. 6. 1S80 Seine of the Total EBTlcaaMit 1»: 55-75 Tnkava* R. Satoki-Tanaoto, a. auaa, K. fatal, H. mo arealTM of KnTlroiMBtal H«alti 35(1}:3C-a« to o\ OJ ------- 7MO-17-7 III Its 85.»678, Bf 39 c, B* sea c, is 10 » E« at (COITXfTCD) IlSSHS Mil Kltaer a,t5 Kidner MIS lime BTPOSJSS BOVt lialYTICU. HTTBOD « n n JOBBSB or casxs »l 15 tj lot giT«n •) 8 of 9 q 12 ) 2 ) « BIKE a) 1.0-6.0 B«/g f»t it) bl 2.3-5.2 agSg {ret «t) a) 2.»«-8.40 11/9 b) 1.50-13.5 09/9 e) 2.01 -4.0 a»/« •et irt ) ».«-9.7 »j/» (net «t) ) 2.7-5. og/j fwt t\| nil i GII mi IITOIUTIOI 1 i l a) 3. 3 » or - 1.5 I •) Bales ag/y (vat »t) 1 t) F«ial«s k\| 3. 1 » or - 1.6 I H9/9 t»«t »t) \| frot « groop of f1 autopsies. 1 tar««te ••itcal •mlnatiou. Japan 1 S«l«s, i«an «g« 40. C rr. r«als. \| i«a* a IT vat >t \| ^etlBS 1 teceaie^ retloerr and n«lter I >ozt«rs, «ge» 55-78 yr, exposed to 1 b«ay let all 1-3 dea4«s. Us ( t«tvM> ceticeoeat a>4 d«ath 0-1.5 fr I it group I aid 2-19 Tt. gronp tl. 1 Cntcols, aqts «3-72 Tr, »ho liwd 50 J ti fr« tke faetorr. 5v«l«i). \| 5IBDH; C»1TEBS; KID1ITS; 1ITSB; 1 I OSES: CO«P»B»TITI rfimiTloiS: 1 IIDITSTSIll ITTnE»i JBlSOBEHIT 1 (ROODS; UTISOIT; IBSZHC: CUBIOH; 1 cism; cpBOsmd; cam?: casrst: \ ccto; isoi: luieumt teia: 1 niGinss: stscnEt: HOITBDIIOH; t tsosjHoins.- BBBlDios: scaiDimi; \| SlmlDS; StlTEE; Til; TOIGSTCI; 1 ZliC; BHITH RlEiRBS: IJDUSTSUl I ttlRSi SinTRS; TH.1BSI3S 1 9.7 * or - 0.07 \| a) Bales 1/y (ret irt) r t) Females J ». 8 » or - 1.4 I g/9 (net irt) 1 rcos a qronp of £1 jatopsles. 1 (oreasie >«41cal etaalutloss, Japan. 1 falsa, «ean tqa 90, ( Tr. Itnla, 1 nan aqe 37.1 jr. \ l nice nmrts; mopsrzs; Jtric I iigami; nsnic: cumin; COBUT; 1 CBBOBIH; Corn's; ISOI; IZBCmT; 1 itnoi: iiemsiOB; aueuisi; 1 SOBinWS; ItTIHOfT; SCWDI99; 1 snniin; Tinim; TIIIDIOJ; zinc; 1 Gain: Bioniit; ii»i: KIDICTS; 1 CHEStBl: CIBEBEtiBfl: BMSI; BDSC1ES; 1 Eiictiis: spusi; LI«GS: aoni: < anus: ccipmnrz ETUHITIOFS; six: I ICSMSIC K1I1CIIE i IHFEEnCI Tikam, B. sazakl-Tasasoto, 1. Jtaano. S. Teral, B. 1980 IrehlTcs of Enfironsaatal Health 3S(U{3«-» Btoae, 9. locaberg. 6. ff«3t«r. f.O. 19AO Science of the Total Environment 16:13-35 Talcaia, R. smiaU-I«sa»oto, S. inna. E. Teral, 1. 1980 IrcStKs of EnTic«nMi.tal Scaltk 35(1):3C-4« (•EIT PaSE) ------- ItbillM 7MO-1T-? n Itf 85,a«7«, m 39 C. B* 688 C, TJ 10 H Rg at 390 C TISS5I MIT liter »«» tm»g ei9 in? nans BOUTS iiumcu. NETIOI n n it IUBSEE T CUES B 9 11 a) « b) 9 4 11 lives 3.11-9.10 •»/» 1.W-S. SO ao/S O.C7-T.»fl «o/g t «t .6-3.3 19/9 (««t »t) •1 2.50-7.»9 ag/g b\| 1.W-5.70 qj/g d 1.0-9.9 ag/g «lt It "BUI " i siiim, HTOHHXOI i amines i i t i i 1 5.20 «n/g I •) Control I Bcaae, 0. a. 01 «g/9 I bl inker groan I 1 foraberg, 6. 3. M «g/g 1 c) Barker grow IT 1 (ester, P.O. t «t 1 1 180 itua 1 C«c«u«l cei«T a»4 BMltec t Science of the total 1 ork«a. «• SS-T6 yr, elposed to t EvrlronMBt 16:13-35 1 t»rjr MtalB t-3 tffil-s. !!•« 1 1 tctma c«tlreM«t itA dcatb 0-1.5 ir \| 1 Is group I »4 2-19 yr, group II. 1 1 Controls, «q«i «3-1J yc. vtto Xlwt SO I 1 lii frei tie factory. S«e4«. 1 1 1 1 siion: ciiifiES; it Dins; IITIB; t 1 IVIGS; COBPIMTITB KTIIOITXOIS; I t IlDOSTitll. nolEd: «!»SflSSSCTT \| I IITWOS; IRIBOII; lISEIIC; UDim; 1 1 cisnui: cmoBXni; COBILT; COPP»: I \| 601,0; INI; URUIII; LEIBs I 1 flivsmsi: BncmiT; 9OLTBDK«on: ( I tnsMOBis; inipioB; SCMOIHB: i 1 sn/iBiira; sunB: it«: TOIGJTE: i \| IIIC; (II11B HIIBBS; X»VSTBIlt 1 I tints: sBums: uumm i 1 .!..._ I 1 2.2 » or - 0.90 ag/g 1 «•!«• 1 Tnkava, B. (««t it) 1 1 Sankl-Tasuoto, B. 1 fco« a «ro«v of (t aatop«l». t imo, K. 1 Coceviic aejical •xaaiBatioms, Japan. 1 Tecai^ B. t Bil««, mtta age 8.t yx- Teaales, I 1S» 1 iea« agat 37. • yr. I IrcklTe ot 1 1 Imlronaeatal Health I TSUI ILEBtlTS; 10TQPSIIS: JUIBs I 35(1> : J«-«» I noBinm nsniCi CIDBI«B: COEILT; I I CBSCS11W; comi; JIM: Encnsi; i 1 1ICIDB; 1»e»ESIOIl: BUeifESB; 1 t lOeiDTBH; IIIIKOIT; SCiWDITH; I 1 SILtnia; ITTUin; tllltlDSt 1IK; \| I ECIDI Bo»Bt; LiTN: nuins; i 1 ciBKBW: cnranuiB: BSIBT: BDSCIES; i I Clients; s»LRf: iwflS: loiti: I I amis: comtiTin zruoitiois; SEI: i I ICRKSTC BltlCTX \| i i 1 ( a) 2.99 m/g 1 •) coatcoli \ Bcu«, 0. b) 2.6 tg/« 1 b> (orlcer group X 1 lordtwrg, G. c) 3.«2 aj/1 t •=! «ot\«c gceip TI t Hester. 7.O. Vet »t I r 19«0 lealaas 1 tcceasel reflaery aid smelter 1 Scieace of tie Total 1 lackers, aqe* 55-76 yr, eiposed to \ EaTlroaieat 16:11-35 I heavy «etalt 1-1 4ecales. Uee t I tctveem letiteseBt »a oeath 0-1.5 jt \| 1 It grow I anl 2-19 yr, groep II. I I Ccntrola, ag«s 3-7i yr, vho llted 50 I I kt fros the factory, svedea. \| 1 1 I SSICII; CWHIBS: KIS1BTS; LIT It; I I IOISS; COBV1B1TITI EV1101TIOBS: \| I I»BSTEtll BT6IDR; SUSDHmT \| 1 MTBOD5: iiriBon; usmc: caosim-. < 1 ctsnn; cnoBinv; COBIIT; COPPEB: i t GfllB; I9O»; IURHUOB; tUD; t i B1K1BE5ES tllBcaiT; 901I3D11TIII; I 1 teosPBoirjs: BtrBUJnrn; scivmtm; t 1 sniBTfi; SIITEB; Tt«: TOB«5T»; I 4 TIBC; IBUTO B1Z1BDS; UDOSTBUL \| 1 1 m«TS; SBT11EBS; IBIIDIITIB I I 1 1 • " (BEIT MGE) to a> Ul ------- Ilbl4i.il 7440-17-7 It Itl 8S.4678, B? 39 C. BP 688 C. T? 10 u Bg at 390 C TISSOE 4420 Biscle 4421 Fasereas 4422 Spleen EIPOSOU SOO alUTTICU METHOD U M a nnst OF CUSS I) » b) 3 a) b) 3 > « I 3 UIGS •) 3.3-5.6 ng/g (Mt >t\| b) 2.1-5.2 «g/g (vet vt\| a) 1.3-6.3 uj/g (vet «t) b) 3.1-.8 sg/g (net vt) ) 2.7-7.0 vg/g (vet m) I 2.5-5.1 «g/g (vet wt) BUI i siiiin iBFOBRHioi 1 i I a) 4.2 or - 1.0 1 •> Biles •g/9 <«•* vt) \| I) resales bt 3.9 * or - 1.2 I ng/g (rat it) I »ros * group of C1 aatopsiei. j forensic •eolcal eiasinatlcns, Japan 1 Rales, »«aD 9» »0. 6 rr. r«alu. 1 i«an «q« 37. rr. ^ I IJICI BLBBBIIS; HJTOPSHS; J1PII; I itoBtin: IZSCUIT; 1 mini; !U6izsiia; mtsntst; t BCSIOI11: 1ITIBOIT; SCIIDIDB; 1 stiEitvs; TiiiniR: Tinoiua; ZIBC; 1 eoiD: B80HHI: LIT IB: nnns; \| CISIESOS; CHZBE119B; HIIBI; BVSCL3S; 1 Fiicaiis; SFiixi: Ln»GS; IOBTI: I 1 IT HIS: CORFUITITE Bf HB1IIOIS : SIX; I ICRIISIC HIDICI»E ) ».2 * or - 1.7 \| a) Bales g/g (vet vt) I D resales ) 3.S » or - 1.4 1 g/g (vet vt) \| Fcos a group of 61 autopsies. \| forensic twaical ezasiaatioas, Japan. j Bales, seas age »0. 6 rr. resales. j iea> age 37.4 rr. 1 1 TBICE six«:iis: itnopsiss; Jip«i; I uvRins; iBsiiic: CJDMOI: COBILT; I cntoarus; COFFES; IFOI; IEKDF.T; 1 tiDioa: BiensiiB: snoiitsB; \| BUBIDIll: IRIHOBT; SCilDIOB; 1 sntnm: TiT»»TOfi; IIHBIB«: ziic; \| GOIB; BSOnil; IITBB: KIDflTS; \| CIBEBBB1: CEBEBZ1LOR: BUST; IVSCLZS; \| F1ICBE1S; SFtEEl: 101X53: IOBTl: \| 1FT1LS; CCSPIBHITE BTU.B1TIOHS; SSI; \| •OHIISIC BF.DKIIE 1 tBFBBEBCE Takava, B. Svxskl-Iasasoto, B. tsano, E. Teral, 9. H80 Irchlves of BOTironasatal Health 35 (1) : 3«-44 Kkava, B. Snlaki-Taausoto, R. Isano, K. Teral, B. 1980 IrchiTes of Enrlrotseatal Health 35(1) :3«-4< rakava, B. SnzvU'Iasaioto, B. liana, K. Teral, B. 1980 Ircblres of EnTiconsental Health 35(1): 36-44 to ------- 7MO-20-2 se at* M.«S». Bf 1S18 C. tt 2B« C TISSBB 023 ketta M2» Brain «25 Heart MSBII MVfB IBUTTICIl BRBOB I Ik BBBBSB at cms al 6 bt 2 HISS BOB* detected a) IOBO detected b) Km* detected e) MB* detected at (OB* detected B) < or • 0.001 ao/e, (n •t) b) Boa* detected B»I i snniL nroiBinoi I i l oae detected \| talea 1 \| ftOB B OTOBP Of C1 aatOpSlB, 1 (areialc aadlcal ezaalnatioea. Japaa. 1 Baloe, Beaa ao 40.6 yr. leaalea. t Baa* a«* 31.* If, 1 l TIKE nums; tnovsKs; JWH-. I KUBIBVB: kBSBtlC) CaDRIBB; CO BUT; I CEBOBCTBl CCfPIlI ItOI; BIBCOIT; 1 innBt siei>sma: BMSHZSI; I SBIIBim; iBTIBOIt: SCIBBIVB; 1 snnrivB; line; 1 CCIBs BBOBIII; 1ITSB; tlDIITS; l ctiiBton-, cEitBBtuiiit tnun; MSO.K; I BilCKkS; SHIN; mwjS; 1CKI; l Bitats; cotsmnn trunnions; s:x; I fOtEBSK BIBKIBI 1 a) BOB* detected I a) Bilos, cetebcai, ) nblecta b\| BOB* detected I I) fcialee, cerebna, 2 >«b]cels e) »oae detected \| c) Bale, ce.nbell.aB, 8 mnbjecta at BOB detected I a] Teaalea. cecebellaa. 5 «ab1ect» 1 1 HOB a 9COBV of 61 aitopiiea. 1 formale aedlcal eiaaiaatloaa, Japaa. 1 Balos, aeaa aoa BO. 6 rr. Tesalos, t te«a 19* 37.4 Tt. I ItlCB BIBBBBTS; WTOPSIKS; JlPlI; < UVBIIOI; 1BSWTC! C10BIBI; COBUT; 1 CEBCBIBB; COMSIl 1BO»: BIKBIti 1 IIBHJ": HUKSiOB! Bueiiiss: 1 SQIIDI^B; aBTlROBT! SCaBDIOB; < stiiim«-. tiiiiivii; mum; live; 1 6CIB; BI08IBI: LITEB; KIBB1TS: 1 CIBIBI9S: CZIDEUKt «»lt; BHSCLIS; l ciictttj; spitn: mtsj; ten; 1 amis: COBTUITITB CTILOITIOBSJ sn; 1 fc^nSIC BEBICIBI 1 t a] lot 9ivB I a) sal« bl Boa* detected \| t\| Teealei 1 1 ICOB a qroap of 61 tttopsl*. 1 (ocBBlc aedical eiailaatlon, Japaa. 1 ealea, lean aqe ao.t jc. Fenlex, 1 BCBB »9* 37. » TE. 1 tt»ci sunns: nrrotsus: JWIB-. l niBimn: ktstnc; CIBIIOB; COBM.T; I cttcHH; canst: ttat; RBKVK: 1 IIBIB4: Bk«lESIVB: UlGtBBSX; 1 BtBiotm: imsoit: SCUDIOB; 1 Stllim; TlTIBlBBi TkBU)lnfl; ZIBC; 1 6CIB; BlOBIIt: IXTBI: XIBIITS; 1 CltBBCIM; CnEBCUVB; Kilt; RVSCLIS 1 (IfCBIkS; StlBSt; In BUS; lOMk; 1 units i ccspiiiTiTE mtoiTioiS; six 1 ICBtlSIC SKICIIB tBTBIEVCE takava, B. Sankl-TamBOto, B. 1BBO, B. Total, a. 180 lEchlte* of EBTlcniaeatal Health (5pt :3^-a* TBkaira, B. svzaU~laviBOto, B. liana, E. Total. B. 180 IICklTCB Of . BBTlcoBBatal Bealth 35(1\|:36-« Tikava, B. S%nkl~Taaaao^o, ai* laaao, K. Terat, B. 180 atckiTu of CalcoBBBtl Hoaltk 3S(1\|:3»-«« (in pisi) N3 ------- seaadian TMO-ZO-2 sc ItB M.«S5«, IP 1538 C, B» 232 C (COBTIBVBD) TISSOB MK Kldner ••27 Xldaer 1 1 • •20 IIPOSHBB IO I i a BitniCal BSTH09 M n BVBBEB OF CIS3S a) 10 b) 2 a\| 8 b\| 20 a) K b) 3 IU8E a) < or • 0.003 ag/g (• wt) b) BOM detected a) < 0.0001-0.00053 03/7 b) < 0.0001-0.0020 aj/j Bat wt < or - 0.01 ag/j (wet t) lone detected SSiB 1 CtBIBal IBFOBMTIOB 1 BEFEBBBCI 1 1 1 1 1 1 al Bat given \| at Bale* I tgkawa. B. b) Bane detected \| t\| Fesale* I Saxaki-Tasnaoto, S. 1 1 aaano. t. \| fcoa a groat at 61 eatepsies, I Tacai, B. I forensic aedlcal •taalBationt. Japan. ( 180 I Bales, Man eg ««. 6 TC. resales, ( Archives of 1 Ma* a 1 1 1 Bat gives \| t) Bales I Takawa, a. Boae detected 1 1) Females f Smakl-Tasaaato, 8. 1 I laano. K, I Fc«a * ?coap of 61 aatopsleg, I Tecai, B, f (ocesic Mdlcal exaaiBations, Japan. I 1980 1 tales, aeaa a«je »0. S yc. resales. 1 acealves of I Man aae 37. • vc. I Bnviconaeatal Health 1 t 3S(l\|:3«-«« 1 TSICE ntetnst IDTOFSISS; JIFIB; i f nOBIWOT; ttSSBIC; C1BBIDH; COB.LI; I I CnCBIOl: COFPES; ItOB; SEICOBT: 1 1 IIDTOII; HiensinB: UBGIEESS; i I Ft'ioini: iRiBOBT: SCIBDIOI: i I stiBBiia: TIIHIOB; TiuDias; life: i I GOIO; BSOBIBf; tirn; RDBETS; I 1 CEBCB£0T: C7BEBE1LBB B3ABIJ B0SCLBS; I 1 pjicsm: spiHM: IVBQS; tent: i \| "TTUS; COBCUITITS B»ttUtTIC«S: SBtj \| \| YCBEB8IC imiCIBE I 1 1 •00 ------- sciadina 7MO-20-2 »tf «,»55». 0? 1538 C. B? 2832 C (COVTZVOXD) IISSW M24 Ilnr M30 VMO »«31 linn SITOSIK torn lIUTTICll RRMD U M •ram or cisss 8 20 ) S ) 2 4 » 1» 9 0) 11 11IGE < C. 0001-0.8005 sg/g < 0.0001-0.0029 a«/g t lit 1 < or • 2.7 «<\|/ qtoop I aid 2-11 TC« qtatp II. I \| Cemtiola, a?«a «-72 re. «lo Iln4 SO I \| Hi ttoa tk» faetocr. 5>daa. j 1 1 I snni; claims; smns; HTIS; i 1 IONS: coiMimn tnuiiioiss i I iiDTSTiiai iteiiii: Biasviiint i \| BI1BOBS; 1RIIOIT; HSmC: C19MBB; \| \| CIS1U11-. CBBOHIUB; COBUT: COPPMJ 1 1 ton: imi: IIKBMMI 1.110; i 1 iimiist; Rncnii; BOITBDIIOB; \| \| tBOSPBORBS; BOBIDIHI: SC11DIOI; t I sninovlTOnaa«tal Bealti ( I 3S(1\|:3C-M 1 tiici ncBfiis; IOTOPSHS: jute i I itOBTIUB; UStBIC: CIDBIDB; CO3U.T: \| I CBICBIOB: copfis; ito«; incms 1 1 iitim: sisHswa: UKIKSK; i \| 1C1I9I9B! IHIBOITl SC»«DIDS: \| t smnn; tutnos: TIIIDIOR: znc; t \| «O19: BIOBI1I-. IITS«5 KIISIIS; \| 1 cnnina: CMtszuni; is»i; MSCLCSS i I PKCSHS; SPIK»: LOBS:; loni: i I itiits; cowaimn ETIIOIHOIS; sn: i I TC5M3IC HIEJCIII \| 1 1 1 1 al 0.0023 aj/g 1 a) coatrola I >ru« D. b) 0.0023 n9/g I b) »ort«r iToan I 1 focdbarg. 6. e\| 0.00(2 09/9 1 c) otkac ttmv II I Vaster, P.O. let »t \| t 1«BO lediau 1 t«cmaa4 rafiasry a>« aaaltar 1 Sclaace of the Total I lorkars, «««s ?5-76 yr, axpoaad to 1 tariroaaaM 16:13-35 I kaavr aatala 1-3 aoealaa. tlaa I 1 tctmaa c«tlia«at and Oaatk 0-1.5 Tt 1 I la group I aad 2-19 vr, ?co«f II. \| I Ccatrola. agca U-72 Tc. nbo llwd 50 I I ki froa tka taetory. s«4aa. 1 1 1 1 si»n: cmimsj iimnss L«S«; i I IC15S: COBPU1TITC miVHIOBS; \| I iieosmu BteiiB; BSISUBBBIIIT i \| 1ITBODS-. intMII; MSinC; ClMIORi 1 1 CMIOS; CBIOtrilB; COBllt; C0»»; I I CCID; IBOt; ItfTIUOa; LHD; I I tiKiitsE: iincnBi: BOLIBBMOT; i 1 H05PB01DS: Bromwi: SCIBSIDB: i \| StUBIlM; SIlTtt; TI»: 10JSSTI1: I I niC: BSalTB lUilDS; 11003TEHL \| 1 nins; sfintRS; TnimoB i i i (Itxt flSl) N> ------- ScuUw 740-20-2 sc lt» »«.9SS9, B» 153* C. tt 2«32 C TtSSTTI M32 nascle «•» Paacreas 4»3» Spl««a ntosm ton tUI. TTICl. BWBOB n n n •ram or cisss •1 » bl » •I « bl 2 6 3 MKI ) ROM detected b> «>•• detected a) < or • 0.001 »9/q <«• •t) b) ion* detected < or • 0.007 m/a liet •t) Boae detected un i mini ivmamoi i icnmcB I i i i I I t) »o«« detected I •} Bales 1 irtaam, B. b) »o»e detected I t) resales 1 SlxmU-Unwto. S. I \| liana, t. j fros a groat of il ••topaics, 1 T«r«i, 1. j for«n»lc ««UcOITI: i I imtS; TOBPUlTltl mi0>TIOtS: SSI; I I IC1MS1C tlBICIK \| 1 1 a) lot jina I «) *!• I lokarn, a. b) »o« tet«etA I 1) P«aal«s \| s«nkl-Tas»oto. 1. 1 I laano. K. j Irca a gtoif of 1 1 aatop«i«a, \| 1«rai, I. 1 Caroalc Mtieal «a«lutloM. Japan. \| t990 I lalcB, Mas «qc «0.< rr. f ••>!«, I Irekircs of 1 f«aa ao* 37.* rr- t CiTiroBMatal Health 1 1 3S(1)i 3«-l I met nsnits; mopsiss; JIPH: i 1 niBim; iisnic; cioima; COBUT: i t CBICMBH: ccmf; ito; BircnBr: i I iigio-a; »JSKsro«: BMSIIISI: i 1 inEiain: imooiT: scinnoB; i 1 annum; TIUIIOT; TIUDIOB; H«C: i \| CCU; BEOBIlt; tITII; ICtDlITS; \| 1 ciimv«: ciBZBCiiai; nan: RosciiS; i 1 tncttti; silts: i BBSS: IOBT»: r 1 «rms: cottumn ETIIITJIICWS; sn; i 1 rcmsic BIIICIII i i i I I ) lot gltoa \| a\| Bal«s \| nkam, B. } Ion a«t«ct«a i t) F«Hl«s \| smkl-Tamioto, a. I \| anno, I. ( Icoi * vroif of 61 a«topi«, I Trai, B. I foraic xdical aiaaiiation, Jspan. \| 1990 I Rales, »a> aq* »0.6 jx. rMl«s, 1 arc>i«s of 1 a«aa aq< 37.1 rr. I ZaTicoai«otl Health 1 I 35{1}:3«-«4 \| T»C« nifttHS! aUTOMIKi JU»; \| 1 iiUiiTOB; itsmc: ciniDB; COBII.I: i 1 cnnniB; co«m; IK»; BIKOIT: i 1 litni: SI5HSIOB: atis»ni; i I imioioa; aitnon: SC»R>I«B; i I snuiTsc IITHIDB: TIIIDIITB: snc: i I eciD; «ton>t: urn; SIMMS; i 1 CMIBS71: czinnuB: >uit: BBSCLES; i 1 tuciMS: svtni: imos-. iom: i 1 BRUS: contniTiTi iTuoiiioBS: ssi: i 1 tcinsic BfEmn i ' ' to ^J o ------- s« 1M 78.»6. » 170-217 C, BP 685 C, T 1 •• Rg at 35t C, 10 II 89 at IISSV* M3S lorta M3S float Blool. MSB wkole* tiNsgiE son* laqestloa IMITTICII BSTBOD I Tlaoroaetrr US PlvoroaetrT •DBBSS or cms a) «2« b) 6 33 210 MKB .0-6.* og/e (*t lit) a) 0.1 1-0. 60 ng/al 1) 0.2»-0. «2 ug/al 13.3-2«.B (4/100 al 10-3 119/100 al BUI \| GBIIMI nrOBHTIOB \| BRBBEBCC 1 1 . » * or - 3.0 sg/q I «tl«s i Intau, B. rtt rt) \| \| Saznkl-Tasesoto, a. j ttoi a gro«p of (1 attopsles, \| laano. I. I tcrvaslc soaical exaslaatloas. Japaa. 1 Teral. B. j Bales, caaa age »0.« rr. Feaales, \| 1980 \| aeaa age 37. a jr. t IrcklTes of 1 1 BaYlroaaeatal Health ( TtiCI BtBBtns; IROrSIBS; J»lf; \| 35(1\|:J6-M j itoaiwDS; iBsiiic; CADBUJB; COBILT-, i I cmcaios; conn; xioi; BSBCOIT; 1 1 iicius; aisiisina: UBetiBsi; i t BIBIDIDR; iniHon: sciionni; i I stLBBinH: niuim: TIHSIOB; site; j I CCID; BBOBIIt; LITI1: EIDBITS; \| I ciBtnm; ctiaziui: BBUI; HBSCLES; t 1 tiBCBiut SPIIM: ia«GS; IOBTI; t \| BtlllS; COHP1BMITE ST>LD1T1OIS: SBX; I I toiiisic neicin i 1 1 1 1 a) 0.265 ng/il \| a) Basldeats at Soatk Dakota a«4 I Bo««, B. b) 0.29 ag/al I igzroaailug anas \| 1979 1 t) n«sll«its of kmo«a solenltecoos \| axc&lTes of I »«a, Eanld clti, 3D. «a«kl} or I Znrlco»»tal Bealtk I teatklr saiplUii, a-2* «lt. \| 3a(C);aaa-ta8 1 1 1 !«ltaY blooa aoior» of various ao.es, 1 j Scnth Dakota, »Tomlnq, I«biaaka, aai 1 1 lotth Dakota. 1 1 1 1 SltlBTUa; BICOD; HIl; ffUBI; \| I ccapiBiTiTi miOMioss: SOILS ; SOUTH i 1 CIKOTl; lOtTB DUOT>: BEBMSU; 1 I S10III6 \| 1 1 17.12 or - 2.53 I Seaifteats vslaq eatez fcoa veils «ltk 1 TaleatlM, 3.1. ag/lftO si \| 2C-1BOO aq Se/1 \| Kaoq. B.s. 1 \| Dana, P-B 1 Illaa. BB \| Sefclvckter, B. 1 I 1980 1 Itl Hit ICO; BLOOD; S»IB; DBIH-, \| 3onx>al ol Toxicology t SITUS : SBIB1IOB: DMIKIIO IITBBi I aaa BBTlroaMBta 1 I 11IIBIS: POPOUTIOB KPOSOBI I Bealtk 6: 731-736 1 1 1 1 20.6 aq/100 al t Safejects (roi 19 collection sites la 1 Ula«aT. I.B. 1 tke U.S. \| Fnbota, J, 1 1 Losoe, T. \ mtBioa: BoinDnoB: IHIBIIM; i Both, s. 1 HOOD; SBI; SOUTH DtlOTl; K> TOSK: \| 1968 t BTCBIK: Bonni: oaio; BISSISSIPPI: i jrcbi»«« of 1 THIS; BOBTB D1ICOTJ: tlSBIB6K>«; I ZBTlroaaaatal Bealtk 1 CUiniBIa; 18IIOU: milll; I 1«:3«2-3»« I lensiiBi; IBHBSIS: noaiBi: i 1 fttBOWt] TMCE SUBIITS I 1 1 N) ------- Seleninn 77S2-M-2 Se »tw 7».»6. HP 170-217 C. B« 685 C. TP 1 nn Hg at 356 C. 10 an Bg at »29 C TISS05 M39 Brain »««0 Brain •Ml Hair •M2 Hair IIPOSOBZ BOOT Ingestioa I 1 lB9Ctioa IIIITTICIL HITBOD n sc us BOBBSB or ciss 9 30 JIWSK a) 0.19-5.0 «9/g C»»t »t b) O.»1-1.« OS/5 (•• »t c) 0.50-7.» «g/9 (»et »t 4) 0.35-2.2 ag/g (net » a) 226.S-423.2 ppb b) 15.2-23. 7 ppb 2-1.98 ag/g BUI \| 6EBnu iiroiiaixoi 1 BBFBBZBCZ i • 1 1 a) 2.0 + or - 1.8 I •) Hales, c«t«brm, 7 subjects 1 Tokana, B. 19/9 («t «t) I Pro« a group of tl aatopalvs, I JicehiTM of I) 1.0 » or - 0.8« I forensic ••dleal eiaiinatioos, Japan. I Enriro»»«ntal Health 119/9 (««t wt) I iales, Man age 40.C rr. Feules, \| 3S(1):3«-« 1 i«aa aqe 37. a ^r. j 1 1 1 Inez niBtiis: iwopsies; juii; t I lIOBirjB; 1ISNIC; C1DBIUB; COBILT: I I CBIOBIOB; CCFPES: IBO»: BZBCOSI; \| 1 IBCI01: BIGIHSHJB: BlfGlBBSI; I I IOBIDIOB: 1IHBOR; SC1B9IDB: \| I snmaii: imiioa: nnoioB; znc; i I 6C10: 9BOBIII; 1ITBR; SIDIBTS; I 1 CIBBBK91: CHEBILlOa: BZ1BT; BOSC1BS; I 1 PHCBIIS; SPIRI: LOBSS; IOBT«; \| 1 SITUS; COSPHJTITI ET1101TIOIS; SBI; I I rOBISIC BIDICIWB \| 1 1 1 1 a) 311.6 ppb I a) S* II, IT \| Cappoi. C.J. b) 111.5 ppb \| t) Se TI \| Saith. J.C. Fresh lit \| Igtopstes \| 1981 1 I Jonraal of Inalrtical 1 Ciiadlaa Indiaas, aortkvcst Ontario 1 Toxicology 5:90-98 1 1 I IISBES; FOOD COITlRIBlTIOf ; 1 1 iicosTiiii tciiaiioi; eornaiot i 1 IXPOSVIS; BDB1I 1BI1S; nSBAI ISB1S; 1 I iura poiinioB; aiBcoBi; BIECOIT i I CISIBIC COBFCOWOS; SKiniDS; 91IIB; I I BflRT: KIDBETS; IITZB: PLICBIT1; \| I StlZBB; CIBlCa; iOTOPSIZS \| 1 1 I F«Tie. 2 rspresentatlTe 1 Chittleboroagh, 6. I Fee-analysis treatnents ate I 1980 1 tibnlateJ. The feasibility of a I Science of the Total I holistic, no-vast policy for hair I Eo»iron««t 1«:53-75 1 nalysis is oatlliei] and snprortei. \| t t I ittrii: TPICI nzBCBTs: BUB; i I msnmn: BZISUBZMBT HZTBOOS; i 1 SITUS; PSOTHBS; COBPlStTin \| 1 ITllOtTIOBS; ILOnBVB; 1HTIBOBI; \| \| ISSEItC: BISItJB; BBOBIBB; CltBIDH; I I CllCItHI; CBICBIBE; CBBOBITIH; COtltT; \| 1 CCPPBI: sunns: GKBBIBIOI: COLD; i ( ICDIBB: IBOI; LJnBlIDB; I SIC; \| 1 BISHISHJB; B1BG1BBSB; BSBCOBT: I 1 (CITBOBBQ8: IICKEL; PROSPBOBOS: I 1 (CTissni: JOBiDiis; samoa; i 1 SIITCOf; SIIRB; SODIOB; STBCIT10S; \| 1 SOirn; Til; TITanm; TOBGSTBB; 1 1 IIK; ZIBCCBIOB I 1 1 1 1 «6 » or - 0.* U9/9 1 lefUents using water fron veils «ith I Talentine, J.L. 1 2«-100 09 Sc/1 \| Kang. B.K. 1 I Dang. P-S 1 lila«, IS \| schlachter. B. 1 \| 1980 1 III R3IICO; BLOOD; BUS; OUR; \| Journal of Toxicology 1 BflLlS; SCIZBIVB; BSIBHIO 11TBB; I and invironaental I imns: POPHUTIOB ZIPOSVII i Health «:73i-736 1 1 (HIT ?IGB) ------- 772-44-2 5« att 7«.f«. n no-217 c. a* «e? c, w •» •• »g it 3S« c, 10 •• 19 at »» c (COM TWED) TIS5VI •«3 •air 4M4 Hill 445 Balr «««« la-art fosm tom A lit RICH HESflOD TlnoroMtry » •0BBM T CaSSS 42. b) a) 5 b) 1 a) 8 1 » UBS1 0.24-37. J« ng/g «. 15-121.43 »g/« . ) 0.25-1.11 ag/g t\| 61. 2-10. 5 uoyg ») 0.44-5.0 19/9 (vet «t b) 0.81-3.7 wj/q (Mt «t 1 1- ui> I eiinit MFOIUTIOI i nntnci 1 1 i i 0.44 ij/g \| •) Coitrol \| Bran, B.I. O.SO «9/g I fe) Biltifli (derail patieats I Bolsbeckar, J. dUu \| sipl«s fre> 7 »calp »its 1* «»cb \| Stuct, D.C. 1 Irt}«ct \| 1471 t 1 clinical ch«lotrr 1 Cklltl: »BTI1B: Cllim IlltOOS r 24(11)I1»M-2000 i Sinn usiiSK: nn: uaimii i t »iosi«-. cncniii caunnts com: i i eciD; IODIII; atistRsc; anus; t I snwrtusj siimt; SOBIM; suirns; i 1 IlllOIOt; ZIK I 1 1 1 t t«lm oe «orl4 llt«nt«x« em th« 1 J«akl», D.I. 1 >ee«nltta« ud blocoic«tntl« of 1 1979 1 l»l«ct»d taxle tne ««l»l» IB ta«»m \| H»-«00/»-79-Ot9, 14 1 k«lr »»J Bills ail otkcr iiiiillai \| pp. 1 ilr, f«. 111 «, diva ui hoofs. 1 1 1»b»l«t«a br 9io«npkie irii, I 1 «»b1«ct», ••>. 9«, izpocuti i I qtillnt. aiilTMS la ppi. and 1 1 nthorltT fen ons 400 r«f«mno>. 1 1 1 I mica: mstin.ii; cum; ctmu i I tmici; mien; nom cm; in i 1 TJILltO; SODII 1ISIIC1; SonBClST 1 i »si«: uiiro nteDOB! TOITID srms; ( 1 IIII; »IIS; 1STXCT; 1ITIBOII; I 1 mmc; Knot; cums; cBicnm; i l cosiiT; CC??H: HID: mem: I 1 HCMl: SE1I1IBH: til; TllUXOB; tlB \| I Kitmot: tiiau POCTUTIOIS: i 1 BioicctmiKio: sioiiDiciioas: HID i 1 POtLOTIOl: POPOLITIOI IXPOSOBI; »»TIS I 1 {CtlDTIOI; T11C1 nSKSRS) IK US t 1 1 1 1 I) 0.77 >g/9 \| •) tipid Cltj. SO nlinifirois ar«a, \| Ho««. B. M as. 3 og/g \| uMltlT « loithlr •iipllaf. «-2l «k« 1 147* 1 t) tip 14 cur, 3D, •wily «aipllng. $ I irchlrM of 1 «s. DiaArnfC shupoa cooUlnlwj Si \| EaTlconKatil H«»lth 1 ta beim IM4. \| 34(«):444-4B 1 1 1 MiltbT blood doaors of Titleaa »q«», I 1 3o«th Dakota, Byoila^, lebraika, and I I lotth Dakota. 1 1 1 1 sn.taii»: BICOI; nil; aim; i t ceiPuitifE miamois: sons; SOOIB i 1 IITOTl; 10B1B K1KOTI; (IB11SH: \| 1 1TCBIBS \| -.-I.. 1 a) 1.8 » or - 1.6 t » ««i«s \| Tnkava, a. og/g (»«t »t) \| i) Teaalia \| SninU-Iasnaoto, H. b\| 2. 1 • or - 1.« 1 \| smaao. K. ag/g (vit »t) I fioi a dtoop of 61 autopsies, \| Terai, I. 1 lorsnslc aedlcal •zaalnatioai, Jap». I 1180 1 til«s, naa age O.K yr. males, \| irckiTes of 1 Man age 37.4 yi- 1 Envltomeottl ^aoltii 1 1 3S(1):3«-4 1 1JICI mums; IDTorsiIS; J»»; \| 1 itOBina: issMit; CJDKOB: COBUT; i 1 cnonint: cottttt itot: BEICOST; i 1 HDIO»; RiGKSItlB; BUCaVISB; \| 1 tiBiBRH: inmon; scixoioi; t i siimni; IITMIOB; TIUDIUI; ZIBC; i 1 6CIO; 5BOBIII: UTEB; KIDHEIS; \| 1 C1SIBBD1: CflEBBllOR: BfaBT; II1ISCLZS; I 1 fllCVHS: SPIES! : lOKS; lOBTa; I < tniis-, coifiHTin miaiTions; sis; i 1 TCREI5IC njDICIII \| 1 1 (••XT P»6I) " CO ------- Selenlna 7782-»9-2 St »tl 78.96. HP 170-217 C. B» 685 C. TP 1 aa Bg at 356 C. 10 •• Hg at »29 C txssnz •M7 Heart •448 Kidney SXPOSOBB SO Ingestion •M9 Kidney ••50 (Uney ngestion alUTtlCU. BB»SOD SC 11 m IDBBEB OF CASSS 1 a) 19 b\| 3 •I ) 9 ct 12 11IGB a) lot given b) pot given a) O.SO-. »g/g (vet vt b) 0.87-1.3 19/9 (vet vt a) 0.37-1.03 ng/g ) 0.31-2. 12 ng/g ) 0.25-0.71 Bg/g •at vt Bot given lot given •III \| GZBIIU, IBFOIB1TIOB 1 1 a) 251.2 ppb \| a) Se IX, IT b) 81.5 ppb \| r) Se TI Fresh vt j Igtopsies 1 I Canadian Indian, northvest Ontario 1 I PISBES; FOOD COBTlBIElTIOB: I lIBBSTtlll ICIIOTIOB; POPOiHIOI I 1IPOSDBB; BVBlt aI»S; ORBal lillS; \| IITBB POllOTIOB; BBBCOBIi BEBCOBT \| CIGailC COBPCOtDS: SELEIIffB; BBIH; \| MIKT; KIOIITS: UTZB; PUCERl; I sum: cinci; IOTOPSIES 1 1 a) 1.6 » or - 1.0 I a) Rales ag/g (vet vt) 1 t) Fenales b) 1. 1 » or - 0.22 \| ag/g (vet vt) I Peon a gronp of 61 aatopsies. I forensic nedical exaainatloas, Japan j Bales, aean age ao.c yr. Finales, j tean aoe 37. a yr. 1 \| TBICt ILIBIRS; aOMPSIZS; J1PII; \| 11CBIIIH; 1BSSBIC; C1DBIDB; COBUT; \| CBBCBIHII: CCPPSB; IIOI; REBCDBT; \| IIEIOH: IISBISIOB: B1BG1IESE; \| BOP.IDIDR; IBTIBOR: SCHDIOB; \| 3IIMT9B; TIUIXOH: TilaDIOSi ZIBC; \| C01E; BBOBIBt; IITEB: KIDBBIS: \| CBBEBBUB; CEISBBtLOB; B31BT; BOSCXBS; I tiiCBBiS: spun; loiss; IOBII; \| 9ITUS; COBPIB1IITE ITIIOITIOIS; SIX; \| FCBIISIC BItlCIBE 1 \| ) 0.70 09/9 \| a) Controls ) 0.52 ng/g 1 t) Vorker qroop I ) 0.33 ag/g I c) Barker gronp n let »t \| edians \| Eaccased refinery and snelter \| aorkers, ages 55-76 yr, exposed to I heavy netals 1-3 decades, fine 1 bctveen retirenent and death 0-1.5 yr I in group X and 2-19 yr, gronp II. I centrals, ages »3-72 yr, who lived 50 1 k« fron the factory. Sveden. 1 \| SflDBB; CtOaTERS; KIDBRS; tITXBi \| HISS; COBPU1TITB ETlIDtTIOBS; \| IBDOSTBIII BTEIFBB; BZISOBEBZIT \| IRBODS: 1RIBOBT: USEBTC; UOBIDB: \| CXSm; CBBOBTVB; CCBilT; COPPEB; \| CCLD; HOB; 11BTB1EOB: LE1D; \| niGlBSSI: BEBOTIT: BOlTBDEBtm; I FBOSFHOBDS: SUBIDIVB: SClBDIDi; I snsBivi: suns; TIB; TUBGSTEI; \| IIHC: B111TB B1Z1B9S; IIDUSIBIK I PIIITS; SBEITESS; TBlLBBlnB 1 103. ppb \| a) Se II, IT 707.8 ppb \| t) Se TI esh vt j latopsiea 1 \| Canadian Indian, nortbvest Ontario \| lISRtS: FOOD CORHIIITIOI: \| IBDBSTSItl IOUOTIOI: POPBlltlOl \| ItPOSDBf; BB»L UB1S; HBBM UlaS; 1 inn POLUTCTOI: micisi; B»cnn \| C151ITC COStCDIBS; SILMIOS; Bllll; 1 niirt; Kinitts-. iiTt; VLicxna: \| STlBtl: CHltl; MTOFSI1S 1 BZFEBBICI Cnppon, C.J. Snith, J.C. 1981 Journal of analytical Toxicology 5:90-98 ynkava, R. Snmki-yasanoto, fl. Inano, H. Teral, B. 1980 irchiTes of Eavironnental Health 35 (1) :36— aa Ernie, o. Bordberg, G. •ester. P.O. 1980 Science of the Total Environnent 16:13-35 appon, C.J. nita, J.C. 981 onraal of analytical oiieology 5:90-98 litn ttsi) N3 ------- 77SJ-»9-2 51 Itf 7».»«. n 179-217 c, B> 665 C, V? I u Eg at 3S« C, 19 mm Rg «t 429 C fCOBTIIBID) MSSJI MSI aa52 M53 ll»ar irosnE toni Imgwtlam IM1TTICU gnaw n » ec n»n or cuss 7 7 a) ft b) 9 O 11 1 IIBSI 1.2-C.2 »»/g (nt t\| 0.15-3.4 ag/g (nt it) ) O.IH-O.at aoyg b) 0.12-0.35 »g/g O 0.11-0.23 ng/a, '•t wt a) »ot gim b) lot glT«> •BIB \| GtEtEll IBPOH1TIOB 1 2.7 * or - ».i I >•!« g/g (mt «t) 1 1.9 * or - 0.98 1 MOB a groap of 1 aatopaias. g/g (»«t «t) 1 fatmile aatical •laaiutiami, Japan. I Bfllctf Baan aga 40«C yir« Ta>alo» j a«ai age 37.* TT. t 1 met ZIEBBBTS; inoMiES; JIPIB; t IHBIIBR: 1BSEBIC; ciouina: coBUt: \| CB1CSIOS; CCJJIS! 1MB- BlgCOET: ^ iBtni; MSKSIBB; IM«HISB; I lotmm; IITIBOBI: SCIBBIIH: \| EtlEBlV!!; 711aBlQS$ T&BlftlQB; ZIBC; \| CCIB; BBODIBE; UTEt: nDBBTS; \| CltmUS; CtBEBHUBi BUB1: BISCtESi i fiBcaus: mm: tnies; torn: 1 llt»13: COBtlBlTITB CTllOlTICIS; SEIi \| rCBEISIC BtCICIEE 1 1 0.19 gg/g 1 a) Coatrols 1 0.20 ag/g I b» lerkcr «TS; SBEITEIS: TtlmSIBB 1 1 a) 269.7 ppb 1 a) S« It. n b} 176.1 ppb \| t) 5* TI Tna% «t \| litopci** t I Ciaadlaa IrnJlan, oortivaiat Ontario \| fISBBSJ rCOD COVTMIBItlO! I 11IHSTH1I JOUnTIOB; WPOUTIOB I IIMSOSE; BQBU ItBIS; DBBH 1BB1S; 1 IIIZB rotimoB: iticnn: BEICHBT I CESIBTC coifcorM: snniiHi BUKB; \| BUR; XIDIItS; LIVEB; FL1CITII: i SHIEE; ctBitt: inopsiEa BEFEEEBCt Tnkaia, B. Sazvki-Iaaaaoto, I. lauo, I. Tarai. B. 994 rchiras of ^nixouental Evaltb 35(1):3-M ElOB. D. loclkerg. G. (•star. P.O. 19SO Sclaaec of the Total EnvicOBaemt 16t13-35' Cappoa. C.J. Salth, J.C. 1981 Joarnal of Inalytical Toiicology 5:90-98 ittn «eB) ------- s«l«nlu« 7782-49-2 Se l» 79.96, BP 170-217 C. BP C«5 C. T* 1 aa Bg at 3W C. 10 •• Bg at 4.29 C (COITII9ID) TISSB! 4454 lung 4455 4458 Basel* I exposing som 1 IBltTTICU H5THOD n •i i •OHBIl or cists •2 a) « b) 13 0 23 C 4 IUU 0.52-15 ng/g (««t «t\| a) 0.044-0.22 njyj b) 0.068-1.56 ng/g e) 0.00 10-0. 301 ng/g »et »t 0.67-3.3 ng/g (mt vtl 0.57-2.2 »g/g (««t «t\| 1MB \| SIIIBII. IBrOSBMIOI I tXrCECBCB 1 1 1 _J._._ f 1 1 7.» + or - 10 aa/g \| rtaales j Takam. I. (Mt «) \| t sanU-Tanaoto. B. I Icoa a eroap of C1 aatopales, \| leaao, E. 1 forensic aedical elimination. Japan, i teral, B. 1 Balm. aeai age 40. rr. resales. I USD ( HI* ag* 37.4 rr. 1 IrchlTM ot 1 I >CYironB«ntal Health l mcx zvBBZws: IBTOPSISSJ JIPIE; I 35(i):3«-»» 1 iiBBiBis; IISZBIC; CUBIVB; COBU.T: i I CBIOTIiT; CCPPZB; 1MB; Bncntr: I ( ItCIOB; BlSHSin: BHUIfSI; 1 l IIUDIBB: aniBOBT; SCMDIDB; i \| JltlBIia; TIUBIW: VIMBIVB; ZIK: I \| eOtDj SBOBTIE; UTEB; KID11TS; I \| C!«lBHJ 55-76 rr, eipoaed to 1 EnTironMot 14:13-35 < aea«T aetala 1-3 decades. Ttae ( j cetMea r«tlr»a«ot aal deatt 0-1.5 yr 1 1 ii groop I aid 2-15 jr, gcoaf II. \| 1 controls, ages 43-72 TC, vho Uwd 50 I j k« froa the factory. Sveaei. 1 1 1 1 iftiEt; cuiims: Kitastss IITEB: i 1 loies: coB»iM?in mintiois: i \| JIBBSIBI»t BISIZBE: niSOSEBIBT I \| I1TB09S; inlBOITi IBS IIIC : CIDBIHB; 1 1 cisiDS: craoBina; COSHT; COFPSC i \| CO ID: HOB; tlBTBUOt; LEIB; ( \| tllGlHSS: BSECfflT: BOlTBOtlDB: 1 1 tsospBOKBs: uraiDiUB; scimims i 1 siiiiini; aims; TIB; TDBGSTSS; i t line: aiaitB Biiugs: IIDOSTBIU i \| IIliTS: SMIIEBS; TJLIDBIDB \| 1 1 2.1 oc - 1.1 fa} Bales I Ynka«a, B. g/g (««t ot) 1 t) reaales \| SnicU-Tanaoto. f. 1.1 * or - 0.76 I I llano, K. /g (net wt) t Troa a groop of 61 aatopslea. I Terai, a. \| forensic ae4ieal exaaiaatioas, Japan. ( 1»eo 1 Rales, lean age 40.6 rr. fvaeles, 1 Ircbives of I lean ag* 37.4 rr. \| EtTlronaantal Health 1 1 35(1):3«-44 \| 151CE nSBIRS; 1QTOPSIK; J»1B; 1 l utBiivB; nsmc: CIOBIOB; COBUT; i I CtBCBIIl: COPPZE; HOB; HEBCOST; 1 \| IBtlTV: B16BESIVB; B1BS1BISI; 1 1 I»IBIBS: innoir: sciioioi; i \| 3HZBIH1; TI1UIOB; TtBkDIOB; ZIBC: 1 I eciB: B«o«iii: IITH: KIDBEIS; i I cfimoi: ciaraiiiog; ajisi; RVSCISS; I l tincssis: spiral: tnvss; tent: I \| BrTILI-. COBPUtTITE CTUOJTIO1S; SSI; \| ( fCJIKIC BZBKItE 1 1 1 NJ vj ------- Seleala 7702-W-2 S« lt» 7B.9S, H 170-217 C, BP 685 C. TP 1 •• Hg at 354 C. 10 •• Bg at «9 C IISSBB *57 nil MSJ Pancreas M59 Tltceat »»so Spinal cord POSIWE MOII Ingest Ion iuiRicu mioD i .. ac 1 1UBBES r cisss » (1 C > 3 1 a» 1 b) 3 tUSE lot gireo Bot glMn 1 1.1-3.S og/q (mt vtl 1 0.»7-1.6 ag/g (vet «t) a) 23. 3- SO. 1 ppb b) 6. 3-16. « ppb a\| lot applicable b) 53.0-180.2 og/g RBII i sunn. iBTottiTioi i BBrnncB 1 l 1 1 0. 18 * oc - 0.59 \| •} Cosea 1 Kaubrocki. E.I. ppa \| r) Bea \| Kanabroeki. J.li 0.58 » or - 0.27 \| left thaab I Greco, J. pa \| llso re»iew4; kao» levels of 30 t Kaplaa, E. FT (t I ctker eleieat* 1 Oestac. I.T. 1 1 Br», s.s. \| Bailtkr 20-6C rr oiaa { Gaatafson, r.S. I 1 11800, D.I. 1 »t TOTS; SEX; mis; sstnij ILDRHOH; i iioare, c.i. I UTiBowt; tusnic: IUIDH; CIDSKTR; i 1979 I CUCin; Cisni: CBBOnni; COBIVT; 1 Selavee of the Total I CCPPE8; SIEHUItJB; SC1.0: Itoi; LE>0; I Enironaent 13:131-10 \| IteiESini; BUSUESC; ICEKCOST; \| I IClTBIini; IICKEL; POTlSSIOa; \| I BOBioinH: siinni; smcoi; sima; i \| SOtlOI; STBOITXai; Til; TIHII08: \| I fii»ivB; UK; IIECOIHIB i 1 1 1 1 1 2.3 » or - 1.0 \| «> Bales \ Tnkan, 8. g/g (vet »t) I t) teaales I Snznki-Tasaaoto, R. ) 0.89 t or - 0.62 \| 1 »aaao, K. 9/9 (vet vt) 1 tcoi a gro»p of C1 aitopsies, I lerai, R. j forensic aedlcal exaataatloas, Japan. I 1980 1 (alee, aean age »0. S jc. feaales, j trckiTes of 1 teaa ry «t \| lentral bora tiasae, avtopsf I 1979 \| lo detectable Se la 6 other patients j laaals of Seorologj I aa4 9 controls \| 6(l)t21-2» 1 1 1 1! TI oU an dial of progressive 1 1 avacalar dlctcopkr- "7-67 TI old 1 \| centrals, dlcl froa chronic ceual \ 1 failaxe, breast careiaoaa. and I I ceroitaTT artcrr diseases. \| 1 1 I 1'TIS; 1DV1TS; iOTOPSISS; \| 1 1IOSOHUSCD1H DISEISIS; SPIBM. COST); \| \| ElOlCdinilTlOW; ClLCfOIi COPPEB; I I TBCI; litt: RHGtRZStt HETILS-. 1 I sitirriR: zitc i i i (HIT IBB) ------- TTM-W-2 3* at« TS.4C. 1TO-2IT C. Bf «5 C. TP 1 •• S? «t 3S« C. 10 M Bg at »29 C CCOBTtlVtD) TISSBB •Ml SplMB M«2 Splwa MS 3 vrica ««<• Brine MSS 9rlm« EivosnE ion lBfStlOB BgeatiOB IIllRICll BKBOD H ec us l«arl«i. 1 T«r»l, S, 1 fOTCBcle »»alcal extilMttoa, Jap«o. \| 1980 I >!«, Mn tcj« 40. < tr. F«ul«a. I Jrchliei of \| MM (TC 37.* TT. 1 ZBTlCOBMBttl B«»lth \| I 35(1):3C-M 1 ttice H.BHMIS: AOTOFSIBS: Jirii: i I unnirav; »»St«IC; C»»HIt)»; COBIXT; I I cERonma: comi: itoi: IEICVET; i I JIDIOI: iieKsniB; uientsi; i 1 imlDiuB: utisowT: SCIPDIUB: i \| StlEtXH; TIH HOB; nUBIDB: II»C: \| I SOID: BlOIIlIi 1ITH; KIDIIIS: \| I ctmtvts cEimun; HIM; HBSCISS,- i \| EllCIItS; SPIBII! LVKSi 10IT1: I \| BIT IIS: COSP1BITITB BTL(TlTIC«Sl SIX: I \| fCRKSTC HIDICin 1 1 1 1 1 •I 2«6.6 ppb \| «l S« II. IT \| CppOB. C.J. b) 12.4 ppb ( t) Si H \| Slltk, J.C. rresh it \| I«top«le» I 1»81 1 I Jcara«l of laalytlcal I ca>i4ia IndUa, Boithnest Oitatio 1 Toiicology 5:90-98 1 1 \| IISBIS; FOOg COIIISIHTIOI; \| I TiDnstaiu pauonoi; MPOIITIOI i I IlrOSBlB; DIBU 1BMS: ITFBJ1 1BE1S: I i mis voiinioi; NICVBT: SBBCOBT i I oi0iiic coifcttiDS; stimat; BB«»; i I BUM: KIDMTS; 1ITBI; PUCBBT1; I I SEXin; Ciiiti: imopsiis i 1 1 79.21 + or - «». 12 I §«sld»ots •«!»» «it«r ftoi nils with \| talmtlte, J.I. g/1 I :e-1800 a? S«/l I Kt4t R.K. ( 1 Hang, P-l) 1 Iliac, TS \| Sckloektcc, B. 1 1 "9° I I1B BEIICO: BLOOB; B1IB; DBIBE; I Journal of loiloolo^f I 9ET1L3] SH.IITHB: BBUtUG «1TEB; \| ana laTlcoaBeatal \| IIZTMS5: POPOHTIO nPOSDBt \| Health 6:731-736 1 1 t 1 2.3 » or - 8.21 ag/1 I I Gaahehaa. 1. \| \| CbMboi. P. j Bataial. BOB-oecipatieaallT «i posed I 1980 I 11-77 yr old, tjom. Fiuic. I Clinlcil Chemistry \| I 26 (9>: 1772-127* 1 sztmni: REIIIS; rsucs; ami: i ( BMSntlBfT BET BOSS \| i i 1 1 063 »j/»l 1 Bapid City, SO, Ml«aH«lo«i aim. I Hon. R. 1 nmklr or aorthly saiplUa. -2« i>k>. I 1«74 i i archives of I Maltky blood doBOrs of vatloos age. 1 BaviroiaeBtal H««ltl t Seitk Dakota, lyoalao, labrarta, and I 3\|«) :»-»«8 t lotti Dakota. I 1 1 t sniEToi: BiooD; mil: ram: i I CCH»BaTITE EVlLVktlOBSi SOUS; SOOTH 1 I C1IOTI; 101TB KlIOTl: ffiBBtSIa: I i iionis i 1 1 00 ------- JSJ-W-2 cz-i«-r2-si ft 96.15 TISSUE •MS Breath EtPOSintE 8OBTE 1U1TTIC1L IETBOD re/us •men or c»sis 8 UK! ' 1.2-UO.O ug/lr mi 28.9 vg/hr SIIES1L nmiUVXOI _ Coapoaii related to noraal eetabollSB. «o other Oataila glvea lealthT allltary a4 ciilliaB eiploTees. U.S. ilr Force School of lerospac* l«4icla«, ages 23-7 jr. 3 IIKSISS: CBtOKIIaTEB BIBIOCUBOBS: CEIfltIM OtSlKC COIPOMDS; cnoBoniimsi nvcnn coiponiits; iBHTi: itcosots: tins: IDOITS miiEici C oak la. J.P. Caap, B.J. Belck. B.E. 1975 IrcKlves of iBTiraaaeatal Health 30 (2): 294-295 !2Q-5«-« C3-l«-?-S «1 92.20 TISSUE SKOSOBS BOOT! I 1 1ULRIC1L IETBOD ec/is imisB 07 CaSXS BaBGB \| 1 lot detect «a-5. 2 ag/kr HEli \| 1 0.7 aj/hr eiHBll UTODUIOl CaipoBBi froi BikBOBB origin, lo ether details ------- Silicon 7MO-21-3 SI »tW 28.086, IIP into C, BP 2600 C. TP 1 » H, at 172« C (COHTIIUED) TISSUE • •TO si ir ««7l Rltaer HT2 linr EIPOSVSE SODTl Injection n lection 1 1 1 1 I 1 M7J \| Injection l»9 I AULTTICll HETBCD US us us IUHBEB OF C1SZS 1 1 1 JUCI lot applicable at applicable at applicable BZH 120 «g 5* «g< 000 «q» SEISE1L IlfOSBJIIOB P«lie». :• reprasentatirs FC«-nslTSi3 treatients are tabulated. I be leasibilitr of a tolistic, na-irasa palter foe hair analysia is catlinea and snpportea. BITIH; TB1CI ELMERS: HUB: mSTBJUl: RIlSVBEgilT SETBODS; eiTJIS; tSOTlHS; COBP1E1IITI ITAlOaTIOIS; »1UBI»OI1: 1IIIBOIIT; 1ISEIIC: BtEIDA; BBOIIIE; ClDHinS: ciicwfi: ceicBiRE; cmtoanju: COEIIT; CCPPBl; 5HIIUH; CTSBIHOB: GOtD; icoiiE: iBoi: Linauvts lEic; HSIESI7I; auetnsE: OJRCIIBI; eCITBDElUB; IICKHI.; PaOSPHOEOS: ECIISSTOS: BBBItltll; SILEIIVi: Silicon; SIITEE; SotUBS; SIBOHTItTB; SD1FDE; III; TIUKDH; THIGSTEt; Hie; zucoiitm Caucasian, a«< »0 yr. Cifeoli it lanqs ivies; Bain: HOOTS: LIVES; BLOOO SIBII; siticci; CISI aisrosirs; IOTOPSIES Caucasian, 890 40 re* Iitali in Hag* laiGS; BBIII; KIDRTS; 11 YES: BtOOO siBOB: sincoi: cisi BISTOBIES; laiopsits Clicuini, >9« 0 re. liboli ic lanji iqiGS; BBIII; KIIIETS; LITIB; B10OD SZEIII: siiicci: cisx BISTOEIES; leiopsrts BEfSBESCS CbUtleborongh, G. 1»SO Science of the Total Emironient 11:53-75 Solow>na« E.T. Jones, O.K. 1»7S Journal of Forensic Sciences 20(1): HI- 199 SOlOKIK, E.T. Jones, J. It. UTS Journal of Forensic Scie«cet 20(11:191-199 Soloions, I.T. Jonea, J. K. 1975 Joucaal of Forensic ciences 20(11:191-199 NJ 00 o ------- 7MO-22- at! 107.86S, IP 9M.5 C, BP 2000 C. TP I n Bg at 1310 C, 10 •• 19 at 150 C TlSSIt «T* Mir »»75 Kiaaer •7« Lint MSVIS IOBIB iMimcii BETBOO I » OBBH r cuts > 8 1 21 •) « « w IIISE J < 0. 005-0. 0»S a«/g I < 0.005-0.18 ag/g et «t a) < 0.005-0.032 »4/« b) < 0.005-0.33 oj/-j ••t rt iul i CEIHII iiroiamoi i BBFEBBBCE \ ' \| levie. 2 r«preMBt«ti»e 1 Caittlebocoagfc, 6. \| pre-aaaly>i* treataeata are 1 1980 \| tabalated. the feasibility of » t Science of the Total 1 Bcltetlc, no-task policy for hair t Enilronaeat 1»:S3-7S I aaalysia la eatliaed aad supported. I I (met; mci ncnrts; Bin; i I lISTItlll; niSIUIEd BETBOBS: I I EttaLS; ttotmsi coariiiTin I I Mimitiois-. limnm; H1IBOVI; 1 I nsnic; Binoa; Btomi; CIDHTUE: i t ciicrjs; cnains cnciioi: conn: t I ccrrn; siLtnrn; SEsaiiroe; SOIB: i I icons; laof: UITKHDB: LUC: I I a»oisio»: uiemsi; SBBCOSI: \| ICITBDnOBi BICKBLi taOSPBOlOS; 1 \| CCtlSSntl; BTOtOIUS: SELIItlH: t I siircoi; sit TIB; SODIOB; stiomoi: i I sum: m; winna; monti; i 1 UK; nicciiot I i " 1 1 ) lot give* 1 a) Controls 1 Brane, D. 1 lot giTeo I t) Workers, qroipa I a4 II 1 lordberq. G. \| I tetter, t.O. I taoeasei tefineir u< aeeltai 1 1980 ( wckec, aqea 55-76 rr. expoael to 1 Science of tie Total 1 l«»Tf aetal* 1-1 tecalea. tin t Inilroieent 16:13-35 1 tt«eea retinaeat and death 0-1.S JT \| I ia oroap I ««fl 2-19 Tt, qroap II. I I Ccatrota. aq« «3-72 rr. «ao litei SO 1 1 ka free the factory. Svedea. I \| SIMM: CIDIKBS; IIDBCTS; LITJ8; \| 1 totss-. coitiuTiTi mniTioss; i I IIDJSTBIlt 1T6IEII; B!»SOBlBtHT 1 \| ttTBODS; HTlSOIt: «BSB«IC: CIDHUJB: \| I.CISIOB: CBEOBIOB: coBiLT: coppu: I 1 coin: iici; unsiiOB: L»O: i 1 iHSaKSt: incnn: SOITBDIIOB; t \| EtOsrHOIOS; NBIDIOI: SCHDIOB; \| \| StlEflVl; S11T?R; TI«; TOUGSTM: I \| tllC: BBalTI SillBDS; IIDgSTlIll 1 t mvts; s>itnns; niLotitii i 1 ..._!.__ 1 1 a) tot gi»ea \| a> coatrol* 1 Brae. D. b) lot giTea I t] lorkera, gcovps I and XI 1 tordberg. G. \| I (ester, ?.Q. I te ------- Itt 107.SSB. n* f0.5 C. B 2000 C, TO 1 » Bg at 1310 C. 10 •• Bg at 1S<0 C (cormtiD) IISSVB J.S MTt •nil ixrosvBB BOUT ilainxcil BETBOD n 11 BDBE-SS or cisss at 8 b) 20 •1 9 b) 11 ur«i a) < O.OOS-O.OCO ng/4 b) < 0.005-0.02* ig/g net «t a\| lot given b) lot given BUB 1 eillBaL ItFOtmiOB J a) lot given I «) Controls b) lot given I r) farters, eroepn I and II 1 I Deceased refleerr and snelter j sorters, ages 55-7« rr, exposed to I k«a»T netals 1-3 decades, tine 1 tatveen retlrenest and death 0—1.5 rr 1 li goarp I aid 2-19 vr. groip II. I Centrals, iges 3-72 it, >no lived 50 \| ki fcoi the factory. Sreden. 1 \| SlIDEI; CIBtTBtS; KIDIBTSl IITBI: I uies; coapuifin mtnnais: I IIEDSTIIU BT.8XSII: BBISmBttn I BITBOCSi aRIBOII; IBSSRCJ C1MIU8; 1 cismis CBBOBing; COBIIT; COIPEB: I COID; HOI: I1BTBUOB: 1I1B: I IlietlCSl; BItCOBT; WIT8DIITO: I iBospBoins; iBBiDioB: sciinimi: \| SmirtH; SIITBI; TIB; TOISSTBI: I IltCi BU1TB BlZalDS; IIDOSTIIU \| PI11TS; SBBMEBSt tEIlOIIOB 1 1} 0.7 « at - 0.7* \| •) lonei pps f t\| Ben b) 0.3* 4 or - 0.20 I left thnnb ppn I llo revleved: knosn level of 30 Dry «t \| ether ilenent* 1 1 Beilthf 20-60 yr olds 1 I irtjiTS; sn; mis; ESTIEI; itOHiinB! 1 iniaowT: iisEtic; BititrB; ciBsiH: \| CllCItU; CISTO8; CBBOBZOB. COEllT; \| CQPVBS; 6ESB1H1IB: GOtD: IBOI; IEAI>{ \| BISIISPJB- BIBMBESB; SEBCOBT; 1 catiBDitVBi ncKiL; ponssiaa: \| IBBIDlaB: SEIBBItB; SItlCOIJ SItTES; \| SCCIOB: STBOITIIIBi Til; TIT1II09; \| TIIIOHJB: UK: ZIICOIIDB « 1 EEFBIEICE Brane, B. lordberg. 6. (ester, t.O. 1980 Selene* of the Total Envlronnent 1613—35 Ranibroctl, E.I. Kanabroeki, J.I. Greco, J. Kaplan, E. Oeater. T.T. Brae, S.S. Gestafson. P.S. VelsOBy 9.8. Hoore, C.E. 1971 Science of the total Bnrlronaent 13:131-10 NJ oo 7««0-23-S la Itt 22.»am. tt 97.K C, BF 881.4 C, TP 1 •• B« at MO C, 10 •• Ig at S«< C TISSBJ ««7* Slool, serei t 1 t » BIPOSBK MBIE 1 \ \ 1 iiunicu rnnm us \ \ \ t ItlMXt OF CASBS » 260 b) 260 1 1 »- MBSB a) lot gitrei b) lot girea 1 t i Bill 10.60 « or - 1.W •eq/l b) 13B.5S » or - 0.77 •eo/1 1 1 t « eBIIML IlrOBMTIOl •) laisas cltj, ts, Uri-iiter mi b) taasas Cltr. BO, so(t-«at«r area IS and BO resident! eatehed for age (•em aq« 37 and 37.7 T?\| , >ez. liigtn of residence, iiritil and •conaile states, occupation, inber cf ehtlim, stoking habits, ht, ¥t. In hard-water area, slenif Icaat liczease In hypertension, BCG •bnocnalltles, ind irperarlceiia. (lists; H1SSC0H: itottss C»CIOT1SC«1I OI3B1S1S: mirriisiai: noon ssjnn: ccBfiiaTlTi CTH.OITIOIS: CIMIOS: cncii«s cBiciitiB: inBiaB: ii«»sm: IMSPBOIOOS: TOUSSIW: I sotimj me; sioiccn-nrntioi; t ntncna »M« \ nrEBicB Blerabm, H.L. nelaehsan. 1. 1 Dunn, J. •mold, J. 1975 Lancet 1(191«):1008-1016 1 1 ------- So41» 7MO-23-S la lt» 22.1977, n 97.82 C, BP 881.4 C, TP 1 mm gg at MO C. 10 » Sq «t 5M C (COsTIIVSO) trssnB •MO Balr _i_ air M«2 Balr irosots tout B iBiinicit RSTBOD US •1 BDBBBB OP casts 31 22 a) 23 b) 14 0 »2 4) 1 •) 26 O »0 B1BSB Bot gi»«n lot given a) 3-19* aq/q b) <7-»0 noyo; c) <7-1»9 aq/q d) 12-196 ««•/« •t <7-9» aq/q I) <7-«96 «g/« B«B \| GBIIfU IBPOtBlTICB 1 1 1(37 pps \| a) leaning disabled 919 ppa \| t) Controls 1 1 learning disabled and soraal 3rd aad 1 «tk grade stndemts 1m Canada. 1 1 ciicna; siGissxm; POTISSIOB; 1 SCDIOS; CUB MB; COB11T; COPPIB; 1 IFCI: LBID: UB«iiBSB; IIBC: 1 cnoBtna: itiBiBB; Bttcmt; anus; 1 BUI: caxiom: ciiim 1 1 1 Beyie«. 2* representati** 1 yea— analysis trttatnvnts ara 1 tatnlated. TV* feasibility of a 1 nelistle. no-ask policy tot halt 1 analysis is outlined and supported. 1 1 iivin; TBici stiazns: am; l issniLii: BUSDIBBBIT BBTBOES; I mils: Ptornis; cowitiTin I IlltOltlOBS: 11DBIIUB; iniBOIT; 1 nsnic; siHoa: BIOIIR; CUBIOR; I CIICIDB; cairaiK; CBBOSIOB; COIUT; I coppts: oiniuB: eEMinva; GOLD; \| ICBIll; IBOI; tlBTBlBVI: 1»I; 1 tisBssraa; BiaeiBssi: RSICIBT: 1 iciTBDBna: UCIIL; PSOSPHOSBS; I IOTIS3I1S; BBBIBIBB: SJLIIKJS; \| SILICOI; SI1TBI; SOOIHI; SIBOBTCTa; 1 SHLP01; TIB; TITlHtlB; TOBG3TIB; 1 IIBC; flBCOBIOB 1 a) 3 «g/q I a) Bale costcols b» 3 aq/q \| k) Fenale controls e) 1« »q/q \| c) 111 centtols d) W aq/g \| dt Rale aaltiple sclerosis patients e) 9 aq/g \| «) Peaale saltiple sclerosis patients f) 1* «q/q \| f) 111 aaltlrle sclerosis patients aedians \ Staple* fros 7 scalp sites in eack t sablect. I CIB1V1: ICtlllS: CBRSll niTCOS 1 StSTIH VISH3E5: BUS; llOBIBOa; 1 ciORiis: cucnR; CHIOBTH; COPPEB; I SOU; IODIII; aiasiBBSB; aiTUS; 1 3tl!lT01; SItrEB; SOBIOB; S01POB; I viiion: UK 1 BBPE1EBCE Fibl. B.C. Carkes, B. 977 Science 198{313):20-206 chltUcboronqh, G. 1980 Science of the Total Enrlronaant 1«:53-75 Hyan, D.I. lolxbeener. 1. Sturt, D.C. 197« Clinical Ckenlstry 2«(1t):1«9«-2000 NJ 00 ------- Strontium 7««0-2»-6 Sr it! 87.62. at 357 C. tt 1366 C. TP ID « Bg at (48 C, 1 u Bg at T«0 TISSUE ««3 Kir EIPOSORE BOOTS 1I1LTTICU ffiTHOD iron BIB or CISES MISS Bill GKHBal IIFOSHHIOI B«Tle». 24 repreaeatatiTe Fr«-»B«lTSi« treataents are tabalated. Tee feasibility of a holistic, »-»ih policy for hair aaalrsls is oat lined aad sapportea. mm; TSICI ELIBIITS; HUB: lOSTBUIl; IBlSOBIinT BKTBODS; BITU.S; PBOTU1S-. COBtaUTITl iTiinfiovs; itninnH: jmHoir; usjrrc: BJBIOI; BBOHIMS; c»xira: ciicni: cetcsiiB: craonoi; COBU.T: CCPPBE; StlLIUB; GEESillOB; GOLD; ICDUE; IBC1; IIRBHVI; IEIE; BieiESIDI; MVGinSI: IBECIBIt fciiBBHOB: HCEH: PHOSPHOBUS: PCIISSIUS; ETOIOIDB; SEIBIIUB: SIIICOIj SI1TEBJ SODIOB; SIBCrilBH; SClf OR; III; TXTMim; TOUJSTEK; fHC; ZIBCailSJB SEFEBERCE Chittleboioagh, «. 1930 Science of the Total EnlcoDient 14:53-75 re en «tbearl- 101.1, HP -3t C. »P M5-1M C, n 3».« ati tt 37«.« C tissvi «»a» BIooJ, •hole MBS Rrlie EIJOSOBE BOUTI Inhalation Inhalation IHITTICH HETBOD sc/ns «c/«s MOB BUI OF CiSES « I UltiS a) lot giT«n b) lot 9 Iran c) Rot given Vot gir«n IEJLI a) 0.« ng/ml b) 0.92 » or - 0.26 ng/«l c\| 0.01 09/1! - 2.12 * or - O.BO •illiioles etllUI UF09B1TI01 ••) Initial lalae t) peat, at 6 hr e) Final valie, at »7 »r Dcs« «as 90 pp« a> anS a} estlnatel froa gcaph Healthy Caucasian 2«-«« yr olds. 72.«-0.7 kg. •Off odor, ilia eye Irritation, van eeawtlon is face. STTtmS; SICOO; tllUattOI: lOOLIS; CITIf; HtTlBCirTES »S hr lean eicretions o* aetabolites. ian4ellc acid and phenTlglTOiilic •eld. Dose «as to ppa. Icaltay Caaeastaa 2**< rr olfla. 72. 6-90. T ka. •Cff" odor, aild ojf Irritaltoo, wars sensattoa in face. StTtNES; BLOOD; TIH1HTIOI; IDVLTS; UBIIE; HETIBCLTTES BEJE5EHCE B»a«r, J.c. Icing, J.D. Karbovskl, B.J. Chenoveth, B. B. HcCartj, t.P. Brian, i.e. 1980 Tozicology and Applied tharaacologr 53:5a-6J Baaaer, J.c. Tonag, J.D. Rarbovskl, E.J. Cnenoveth, B.B. BcCartT, l.P. Braan, I.B. 1980 Toilcology and Jppliei Phuraacologr 53:S«-63 to 00 .p- ------- Siltli, ntlrt propTl <• Cl) Prof tarn, 1- fMthftklo)- f» CD 3!77-f5-» et-Bio-s 01 90.1. IF -113 C. B» 95.5» C TISSttE •age Breath EXPOStTBB MOTE tniTTIClL SEtBBO 8C-SS or CUBS " S« (387 naplas) BMSS lot giv«a sui SaoMtric G1IERH ZVT0194TIDV B«aanrl at 25 C a4 7«0 aa •« 11. 5t oecmtme IOMC afl appn oa-Slgaa Halts 0.39 «4 5.1 mayl ecaltkTi. 1B-3S TC old. nonaMlting, CHcacjo, II. iiqidly controlled tipatlacntal caaUtiou. mug; 11COHLS; IlLItOIS; 1DUUS; ceitnrnun BrosocfiBOis; TOIITILS CESIE1C COEICHBOS: BHI.TH aiZlBCS; IimntlO": aiTlEOllSa; antBOLRES; IOPBI1TTOI TIPOSOM: DEBIE BBS taaeK* BEHBMH, 6.B. O'Vaill, B.j. W7S Joamal of laalTtleal Toiicologj 3:225-23* si lew n s 32.06«, C, fit abort »».& C 1ISSVX M87 BrtMlli .B8 Uttlr »••» Balr :IPOSOB1 BOVTE Inhulitlon aiunmt HETBOB PIXE n BOBSIE or CUES 1 a] 2 b) 10 jHGt ~~ lot ql¥«B a) 2.T7-3.99* b> 2.46-3.73T am \| 1 S.9 n« a) 3,'sr b) 3.23' BleUaas GEIH1I IIFOiaiTIOI « 1 saaplaS it rat* of 1 I/ail. 2-10 •In aftac baralaq * arc ««Hin Epr««BtatiT« (iv^aBaLTftlc traatBVBtc act tatvlataa. Th* f«»«lblllti of a leliatlc, no-»»k pollei fax hair aaalTaia 1 cmtlln«4 aad supported. tlTICT: TB1C! tiimwts; Bin; ICSTBtHl; BIASQBVBBVT RRBQOS; irtiis; fBornis: COBPUITITI fiiimiOES; itvalKiB: IRIBOIT: 1SSCTIC; BUIUB; BIOBIIIj CUMOT; ciicnrB; CBicsiii: ctmoaius: COBUT: copvn: smma: OEintnvB: COLD; »6B«sioi: aiasujss: BEBCOII: BOtlBDIIHH; 1ICKS11 nOSPEOlOS; CCTIS3IVBS VBB1BIV9I; SBLEVI1TB; S1IICOB; SXLTEI; SODIDB; SIBOITHTJ: SVlfm? Til; CTY1VXDB; TVBGSlEt; 1IBC; IltCOlIOa a) Coitroll tl 8alti.fl* iclccoalc patlcata Saapl** fxoa 7 scalp aitaa la each jvb 3et CIII01; IDOITS; CEITU1 IE B TODS £T3«B DISUSES; "Att; 1LOBIIQB; BIDB»E; cucinn; CRIOBIBE; COFFEE; ccto: I09IBE: BHCUESI; EETILS: imiins; sitTini sooioii; snrm: tiiioivs: ziBC EEPE1EBCB Unlsaon, t.B. Dasaaa«ler. G.6. Joktuaoa, T.B. Uncb«ater. J.t. W7* lanala of Occapatioaal BT9l«B« 19:225-23* ChitU«bozo«gh. 6. 1980 Scl»nc« of th* Total EnTitOBMut 1«:5J-75 Byu. D.E. Eolxbeckcr, 3. Stuart, D.c. 1971 Clinical chnlatCT 21(11\| :199S-2000 to 03 Ul ------- Tellarlaa 13494-sa-* I« Bt 127.6. IP 449.5 C. ft 989.8 C, »P 1 ma B» at 520 C «ss« 4490 xidaey »wi Liver 4(92 Laag nfosm BOOT kuimcu Banco n u BBBBEB OF C1SSS •1 « M 19 a) 8 b) 19 8 19 IMG* a) < 0.005-0.33 ag/g b) < 0.005-0.2* ttg/g let t a) < 0.095-0.12 ag/g b) < 0. 005-0. 12 «g/g Vat «t < 0.005-0.025 «»/g < 0.005-1.06 qg/g at vt Bsii i CBIBIU. IBPOMMIOB i nramicx i i 1 ! a) Rot givea I a) Coatrala 1 Brate, D. b) lot givea \| I) Workers, groaps I aad II I Borabarg. 6. 1 \| lastor. ?.0. I laceased reflaery aad laaltai I 1900 j ccrkara, ge* 55- TC ft, expoaed to 1 Scleace of the Total I taavy aetala 1-3 decades. Claa 1 Eoiironxint It: 13-35 I tatnaaa ratltaaaat mtt daatl 0-1.5 rr 1 I ii qroap I ul 2-19 TC, gceip II. 1 \| Coatroll, aqta 43-72 yr, to lital 50 ( \| ka froi tka factory. Svadaa. 1 1 1 i sitwi: eatiTBSi KiDasrs; iirsi; t I uiss; comiinn immiois: i I iiDBSTiiii noiEHi actsomni i t BIT BOBS j innoit; usnic; i 1 inimna: ciDfliiB: cssim; CBBOBIDB; i \| CCBalT; COfPIl; COLD; IMI; I 1 iiRBitui: LIU; uieiRSB: nictuT: i I lomotnB: laospsoiiis: BDBIDIOH: i \| SC1IDIDR; SBUIIOf; SIITEI; TIB; I I TVKSTK: ZIIC; BJ1ITB HEUSDS; 1 \| mOSnXal PllITS; SIU1TEBS \| 1 1 1 1 a) fat giva \| a> Coatrola \| B£vna« D. b) Bat gim I t\| v«rkats, groups I aaft II ! lordbvrg, S. I 1 Waster, P«O. 1 laeaasai raf laarj aad aaeltar 1 1980 ] icckars, a; BIIGIIBSB; BEBCTSI; i I BCIIBIIBO'l: fflOSPBOIBS: BtTBIBIBi: I 1 scMDins: snttiDB: snrzB; TIB; i \| IHBC5T»: IIBCj BBU.TB MZUtS; 1 \| IBOISTIIll ?11»TS: SIBITBBS I 1 1 1 J Bot given 1 a) Coatrols \| Broae, 0. lot girea 1 r) lortecs, gioaps I ud II 1 Bordbacg, G. 1 \| Waater, P.O. t taoaasad ref laary aad aaaltaz 1 1980 I tcikers. aacs 55-76 yr, axpaaad to t Selaaee of the Total I Iraarr aatals 1-3 Oacadas. liaa 1 Hnricoaaeit 16:13-35 \| tataaea iatlraa»t «»4 death 0-1.5 yr 1 1 la group I aad 2-19 yr, groar II. 1 I Coatrols, ages (3-72 yr. aho lltai SO 1 j ka Croa the factory. Svedaa. 1 \| SMOtB; CICaTXRSS EI9BRS; llTBi; I \| IOBSS; COIPIHTITB ETltHtTIOBS; I I IBEDSnilt BieiEBS; BKtSBBEIEBT I \| BITBODS: aBTItOBT: »SIICJ 1 I iiitraivB: ciD«m; CSSTOB; CHBOHIBB; i I CCIILT: cotrn: coin: isoi: i \| tlKHJUnS; HIS; BaBCllBSI: BJSOJST; 1 I tOlTBOEBtm: tBOSPUOlOT; BDIIDITia: 1 t 3CMOID3: SCItBIOB; SItt'B-. til; t I 1B1GSHB: tine: Hnm BIHSIS-. \ \ IIDITSTII.I HUTS; SBSLTIIS 1 1 1 to 00 ------- t«rt-Mtrl iinlflt* (8 ci\| nl«lfld«, fcif1.-dlMtkrtet»rl\| C» CI-8U-S2 II 178.3 tissn «W3 Brcatk sifosvn Mm lutmcu BITBOD OC-BS fJBBEF or cisss 5% PB7 saplal tues lot glm n>i - 0.509 »g/l 0oatllC eiBtBu, inoBBMi«B Rcaiond at 25 C aad 7 SO •• Bg 21. M occurroc* le««t »»1 ivpar o«-Sl. Cticaqo. 11. sijiSlr contzoUcl •tpnlmtil condltlots. flllTB; I1CCIO1S; I11IIOIS: 1D01TS; CE10IIIITID miOCllMfS; WllTILE ciGuic concnos: RIIITB IIZUBS: niitKTci; imtoiissj imiEounss ICmiTtOI IIPOSISB; D8B1I UMS isnsnirci KtataniDiki. B.K. BCUCN, 6.1. 01111, S.3. 1»7» Joarul of taalTtical Tnicologj 3:225-2M 11 10. 37, B> 303.5 C. B> l»57 C. T? 1 M Bq at «25 C. 10 •• Bg at 1000 C 1 tissut MM cerebrosp Ival flald Saliva nnsm tens l»««Uo. - 1BU.KXCU IBWOS las US IDBBM Of C1SM 1 1 MB6B lot givex a) «-0. 2 ag/al b) 10. 15-9. IB ag/Aar isii 0.2 ag/1 .. - , a) lot glna b) Bot glr«i GCIlnl IITOISITIOI \| ! dari after 1 a. 28 jt old, koapitallnd dajs aft«c lagwtlag tkalliaa Mltato. lover abdoalaal pai»v aavcaa. >TC«rsthaala of lliba, roalting. l«tbam, dte«lMS, dacraa««d blood Tt»a«r«. len of scalp aad tody kalr. mttios; iiiiL Foiscwiis: CASE 11S1O1IBS: 01I«1; SttlTl; IT1LI: ftCtS; SOICICt; CEtBBROSVIIU TiaiO a) 7 aad 23 S«T» a(t«c t g b) DCT< 7-» aid 23-2« attar 1 9 San valaes aatiaatad froa gzapb 26 JT 014, koapl tallied « day after iaq««tlg tkalliaa calfate. locer akdoiiial p«ia, aaiee. hi^ecaatlieaia of llab. voiltlag. letkargr, drevaiaaaa, dacreaaed blood \|t«nre, Icia of acalp aad bodf bair. ICUUHB; Btlll fOISOIIIS: CUt iisiotizs; nintj sutft: ITUT; nets; smciiz; cnsBiosmu. naio XERBHCB 1 1 (ickelal. r. fioao, T. iSaardla, I. retrial, B. Banto, 1. 1980 icealm at Tozleologr (3:321-325 Blchelai, t. Bono, r. «aardla, I. recrixl, B. lano, 1. 1980 trcKlTes of Toxicologi 43:321-325 t-J 09 ------- Italltae Itl 2»>.3T. II 301. S C. B? 157 C. TP 1 »a So at 825 C. 10 aa Bo: .t 1000 C XXSSVI 419ft Vrla« imsns torn I»«tlOa immcn. •rraoo us nun or ctse , itiei 5.6S-0.2? »9^«y mi (at \| \| i) tot giT«B 1 1 1 1 1 1 1 1 1 t 1 1 — — — . * 1 t uti i 6! ni»t uroiunai 1 • a) S.3 Dj/al \| a) I?0 aa/8 ir ta «t«dr »t«t» bl «. 9 m/il I t) 350 •«/« kr plu 100 aq 1 aHopariB«/8 kr to steady atat. 1 1 t«a-aok«ri, aa«* 29-35 yr, on 1 iaatklM-fr<« dlt »8 kr. 1 I I9SI11I.I1; ItalTS: BLOOD PllSfll; 1 otiitt oivs iirsticfio: noes: 1 CCHMRITITt ITII01TIOIS: I TBiopmiiits; tmnsi BRIBOIISI; I imtotrres i 1 a\| 104.9 tor- .$i! of \| a) 250 aa/l kt dos \| t) JSO ag/* fcr plu 100 ag t) ».B »or- 4.5 of I allopariaol/t kr do** 1 TiMpkrUla* pl«a a«tboltt«, ataadr 1 (tat, ta 8-hr arlm. > SOU aa 1 1,3-dlMthylnrtc aeU. Data 1 anllabl« fct IT doa«. t 1 lea-Mokara. aq« 29-35 ft, on 1 xaatkliw-fr« aiat M kr. 1 1 itsniui; leniTs: HOOD PUSBI; t OlttZ; 9(03 mitlCTIOI; DBOSS: 1 CCBtHlTlrr (TlLOIIimS; I ittotmiinsi snins: imeociSRi 1 KiMotms 1 1 i nnmcx i t 1 STTfUl, J.J. t 'la?. I.H.B. 1 Farka. J. 1 Birtatl, D.J. 1 197* 1 clinical nacaicolojr 1 anJ Tkarapaatica 1 2«(5):««0-««7 1 1 1 1 1 I 1 CrrgUl, J.J. t (lav. !.»-». 1 Fatkas, J. 1 Blrtatt, B.J. 1 197» ) clinical Fbamacolo^y 1 M« Tknp«atics 1 2« (SJ : ««0-«<7 1 t 1 1 1 1 1 1 1 NJ 00 00 ------- melt, ioi«aioaiir?iel oatlmts ItULTS; BBM1 DISSISB; BtTOmSIOB; noon-, aniBTntntsiTB IBIITS; noe TKIUTt COBIUHITB ITfllOmOO: smsran curai; TKOCIMITBS a) SaokvrSr attar 0.032 if/kg fa •actaria, IB iasa, 2 >k t\ Sabtact9 a>4 dosa aa ia a) v attar 1 ao abatcatiom froi sacking Staa$T stata 1»»»1. »•«>« • l^itifieaatl) AlCfaraat. (aaltfeT 19-(0 ?r olfta, saoiei at l«»«t t jack of elaanttai/oaT. tlUSS; 3BOII16; TOB1CCOS; IICOD tusus coBtumn wuonioss; IVTlCQUllaVISs BWIB01I3B; TI1IBSS: TBIOCtlBtllS xsrtiact Bognn, B. ttOXOtf J. Xarcki, J. Giert, 3. lagltli. t. Bitkov8ka« B. Colabak, I. 1979 Clinical Chaaistrr 25111:60-63 -- _ SaAaaBB, K. Shapiro, S. Taltoa, B. Carroll, r.t. SalliTan, T.J. 1979 Clinical Vaariacologr aa4 TharaDaoticA 25 \|3) S 309-31 p«BtaB* (lo nssn i •Ml Breath IttOSTOt BOOTI 1»IITTJCIL 1 vmvob OC-HS BQRBiS or cisis SO (37 naplu) BUGS Hot «lT«a Ola I 0.421 og/1 OaT< 18-35 rr 014, nomaoklwi. vctaa blacki aa< Caucasian. Ctlcaqo, It. liqlill eoatcoll! «iB«ri«atal condition. tBUTB; UCOtOLS: IUI10IS1 UttllS; CHOBTI1TED BTDBOOIBOIS; 1OHTILI cteuic coBtcoios: BBUTB BIUBCS: iiauaTiOB; «rriBoiisa; BRIBOI.TTES: fCPBtlTlOX lirOSOE!; OBB1B IEJIS Bxnmcz Etoto«T»»ii. BK. Bctncao. G.I. O'Mlll. B.I. 1979 JOUMl 01 U»lTti=«l TmicoloaT 3:225-234 K) 00 \O , 1- (8 CI) CI) 91 776. 13, Vt 235-236 C (4«eop) IISS11 • 502 eiooi. tervat ixrosnii BOOT! inLnicu IIITIOD BtlBBIE OF CISS5 23 BUGI ». 5-11.5 ag/100 al BE1B 7.7 DJ/100 «1 GEiiiii iwrosainos HCfPIOI'S: BIJSOBI1MT HETBOCS; BLOOD smn: Tttis - KIEtESC! Broun, S.I. •vtbeav^t J. 197 Joortil of Pharaacvatleal Sciaaces «(B):11W-1217 ------- tig 7M9-J1-5 Itf m.C. V 131.5 C, BP 2507 c. fP 1 •• Bg at 1C10 C. 10 u Bg ft M»0 C I tissn i ixtosiu totn i i • i t 1 (503 I lair a50l Vale 1 lUtRICU HCTBOO . 1 •ram or CISBS MICE nil i esBEiu Mfoiawioi I i i 1 tarln. M rapnsntatira 1 fre-aaalrsf a tr«ta«t« an 1 tabtUtvt. Ths fusibility of a 1 aelistie, ao-msl roller for hair 1 laalysi la cotliaa* «n<5 «ipport«a. 1 tmn; met HUHTS; nil: I lesnuti: mmmn serwesj I (nits; itemise cotPiMTin 1 iTimnoiS: imiliW: iniwntTi j nsnicj Bum; uonis; caraxm: 1 cucxoi: CBtaiiBt cRonoi: coeitr: j ccffit: giuim: CTMHIBB: COLD: 1 icoiii: I»os; iiRiiini: l<»: 1 neiMUi: iiiGiissi: sncsin 1 loiTioEioB; nc«ni Mospnows; I IOT13SHB; IHKlalVB: Sill HOB; j I JI1TCOI; SIITBB: SOOIIBJ SIICIH0II 1 i • 1 I \ 1 •ws n a) 8 1 a) < 0.3-6. 87 s«/g b) 14 1 b) < 0.3-S..W ««/» \| Bat «t 1 3n tat; tit-, nruiii; TnEstn; i me; nicoiing i 1 \| 1 ta>i«v of >ocl4 lltaratar OB taa> 1 a«c«atlatioa «»* blacoacuttatlon of 1 nlactsl toxic trac» aattli la amua I kale aa4 aalls and otkcr aaaaaliaa 1 aair. far. atils, elans ail hoofs. I Ktalatad bf geographic ana. ( it5«eta-, ttt, a««, cxposara 1 gtiaivct, a»lrsas la pp. aafl 1 ictaarltr fr«a or»r 00 za>farBo>. 1 t irtrci; iDstiuii: CHIBJI! czniii I iinici: mtctti iTDOtt list; in t if HMD; SOUTH mild; somraasr I mi t oviTte KiiGBoa; ontti stuts: I fin; laits: imnt 4irin>ii: 1 »s»xc: BOBOI: ciBini: cnoiioi: 1 CCSU.T: ceatts tut racoti: 4 iicnt; snmvv: r»: u»oni; in f (OtlOTIOl; IITUI OPOHTIOIS: \| tTOICCOBOLKlOls BIOIBDICIIOIS! LtIO I EOimioB: ropOLiTioi szposiru: run I poitinios; TIICB Hire rrs: amis 1 lot gla 1 a) Covtrols » fat eima 1 t> lockaca. grovpa Z tad II 1 1 rc«ui4 rcflMty aad aaolter 1 •oikaca. agaa 55-Tf it, •xpoacS to I l«»rf aetl> 1-3 ivctdts. Ti»« 1 t«tw«a rvtitcaeat and dcata 0-1.5 r' 1 it groip 1 »d 2-19 yr. group II. 1 coatcals, agas »J-T2 re. »tt» Iln4 50 1 >i troa tba factory. 5aia»w t \| SMOCr; CJDJTIBS; ZIDIBTSt 1ITFI; I HUBS; coRMiiTin zritDiTiofs: { III«STtIlt ITGIEHi msnXBNT I iwaons: tvtiioti: Msmc: I itu o ------- tin TMO-31-S Si ati m.«9. n 331.9 e, tt 2507 c, TP i •• »t wio c, 10 •• 19 «t 18»» c (COIIIiBID) nasii •06 HT.T aSOT laag 1 ixiosoti toon IBUTTXCal RETBOD n BI BBRSSB or cisss ) 8 t W •} 8 b( 19 tuat } < 0.3-3.18 ag/g b) 0.3-3.70 eg/g at «t a) 0.3- 2. 15 ag/g t) 0.3-3.68 eg/g fat t B»B \| GIIZSU XBPOIHUIOB 1 1 ) lot givea 1 a) Coattol ) lot girea 1 t) lockece, groups I and II 1 I Caeaaaed ret taerr and aaelter \| aacfcecs, aget 55-76 TC. expoaed to 1 keavy aetala 1-3 deeadee. Tlee \| batveea retireaoat aad doatk 0— 1.5 yc I la gcoap I a«d 2-19 tr« group II. \| Ccatrola. agaa «3-72 yr. who Uad SO 1 ka tzoe tka tactorr- s»«a«a. 1 t SUOII; CU1TCM; HDIITS; lim; \| IlieS; COBP1HTITB BT1101TICBS: \| IIDDST1I11 1JSIIIB: nUOIIBEIT 1 iiiBOBS: tniKiit usmc; I TH.IH1IT1S; CIIIIOR! C5SCTB: CSIOBIDB; 1 CCBUT: conn: GOLD: HOB; 1 iimiBui: iiu: HKtBtss: incmi; \| BClTBOSIVBt IBOStmOtBS: «DU9T«>: t SCIIDIH; simm: SIITIB; TIB; 1 ToissTSB: UK: asiin BIXUBS: \| IBPBSTBIll P11ITS ; SBSITBBS 1 a) Bot given \| a) coatcols bt Bot given I ti lortera, groups I aai II 1 1 Keaastd ref latry aad aaeltet \| acifcera, agaa 55-T6 rr, expoaad to 1 aaavr aatala 1-3 deeaiea. Tlae 1 tataeea reticaaeat aai deatk 0-1.S TT 1 la gcoap I aad 2-19 vc> gcoap II. 1 Controls, ages »3-12 ji. aao lived SO 1 i froa the factory. Swedes. 1 1 iiiin: ciEtfns; HOTEIS: iir»; I macs; comnmTS mimTioBS; I 11DOSIIH1 BieilBC: BiaSOllIZBT 1 BITBOBS; miaOBTs USBBIC; 1 lllimni; CiDHTOB; CSSIOT: CEIOBIOH; I cciui: co»a; COIB: HOB: 1 lllTBim; IUO; BlBGlBKSBt BElClTtT; 1 BoinpEBaa: IBOSWOIBS; BUBIDIOB; l scininii SZUBIOR: SILTIB; ni; 1 IBBGSTBB; XIBCi BttlTB B1Z1IDS: 1 IMOSTBIll IUBT5: SUBIIMS 1 IStttSICI Bcaae, D. Bocdbecg, G. Beater, 1.0. 1980 seieaee of tka Total Eaviconaent 16:13-35 Bcaaa> 0. aoxAbeTg, G. aestar, P.O. 1980 Scleaoe of tke Total Enviconaeat 16:13-35 VO ------- Titallaa 1MO-32-C II It* »7.»0, It 1677 C. TV 3277 C, T» 1 U If at 2180 C. 10 •• Bj at 280 C TISSUE EIKSVIE tons IMUTICXI S PI BOB »SOS lott» 1 1 1 1 1 1 1 I ,,0, Brain 1 1 1 1 1 1 «519 1 Br«th (Sit lair i Ittalaticn n n i i I put xmm i iie* i BSII i eiiniL nromnoi I OTEIEITCS or cisis ill 1 i i i i t ll I 2 \| < or • 2.8 «g/g («t t) 1 t.< « or * 2.0 »«/g I »«!«« 1 T»ka»a, a. 1 1 (»«t »t) \| » Saioltl-Taawoto, B, 1 1 \| »ro« a 4»ap of «1 aatopslaa, 1 aaaao, K. 1 f \| femtslc ladteal •xaainati.ODa. Japaa. I fatal. H. I I \| Balw naa g» »0.6 jt. Paaalas, I 180 I \| \| ««aa ago 37.* TT. \| Ireklra* of III \| t>Tlronantal Hoajtk \| I \| 111CZ ItSIZITS; aVTOPSIKS: JaPtl: I 35(1):3t-«« 1 i i jioiiiDi: itstnc; CIDBIBB: COJU.T; i t \| \| CtlOIIiri; COITIS; Ito>; BIICOII; \| 1 i i ntxai; iinxstvi: uiamsx; i \| \| 1 mniORs 1KIMR; SCllDISg; 1 1 i i SMWIOS; tnuiaii nuDtoi: me: i l i i eciB; BBOsiH; IITXI; rrpiiis: i I \| \| CIIJBSnlJ: CEMBKILVB; HUT; RVSraSS; I I i f tucmss stittrt imss; ton: i I \| \| BCTU3: COBPM1TJTI CT1LOITI013: 321; 1 I \| \| TCttlSIC NDICIM \| 1 1 • 1 1 1 II 1 a) »OB« d«t«ct«J \| a} «oi« 4«t«ct«d I a) lain, cvnbraa, 9 iobl«ct» I Takava, 1. 1 b) < or « 9.5 ag/g («at I i>) •-> » or - C.7 I t) Taaalas. c«r«bria, 2 obj«ets I 5anki-Tanoto. B. 1 vt) \| o?/g (>«t »t\| \| c) »«!•«, c 1.* os/» (nt \| c) O.JS » or - a. 62 I t) remits, cer»b»lltia, S »ot1«ct« I Teral, B. 1 «t) \| mg/g (»et nt) 1 1 WO \|t> < or • 3.6 aq/g (»«t ( J) 1.3 » or - 1.8 1 Fzoa a nconp of 61 «ntopsi«a, I a r china of 1 »t) \| »j/q c««t «t) \| foraaslc aiieal axaainatioia, Japa«. 1 Inrlroaaeotil Bcaltli 1 f 1 Bales. MBD ao« ao.« ft. I«»alas, I 35(1):3«-«« i 1 1 i«an aq« 37. TT. I III 1 1 I \| TMCt nniRS; aOIOISIIS; J»PH; \| I i i mania: itsnic: CJBSIOI: COBIIT; i l i i cnoBioi; corm: cioi: BBBCUST.- i 1 1 1 I HITS; SKBISIOB; »«»S1IESI: \| 1 i i igeioiDR; amsoir,- SCJIBIOI; i 1 1 I snnlDI; T1I1«IO»; MWPItJS: ZIITC; I 1 i i sen: Homi; LITZE: nottis: i 1 1 \| CtSZBIO; CtEZBEUDB; HBtRT; ROSCLXS; 1 I \| (iVCBEIS: SPlEEIs 10KSS; 10ST1; 1 1 \| anilS; C01P»I»TITI ETUVITIOITS; SBI; I 1 I fOEZISIC BECICIIE f 1 1 1 1 I 1 Wot glYtn t 12.2 14 1 « 1 saapla4 at rat of 1 1/aia, 2-10 1 lltMlaaoa, X.I. I ala aftor tenlng • arc «Ulaq rod a. I De»«4ela«r, 5.G. 1 1 Johansson, T.8. 1 Oai»erslt» pbraics stop, rlotlaa 1 Blcchoster, J.I. 1 1 1»76 1 KCBIDl; lEOtTS; 3RE1I8: CllCIHR; I inMls of Occupational \| CtlOtlfZ; CIWCIOI; COPPEB: I8OI; I BrgleM 19:225-23 I IZIB; ntieiiESE; ncrst: POTISSWH; i l Sturm; T«»nnn; TIUDIITH: me: JIB i l foituTioi; nets; iiairsmu i l iimsranzs; TBICS ELEBEETS i < i 1 i 1 B«»ia». 2« Mpraeitatin I Ctittlaborougk, G. 1 Fr»-aBaljsls trcatmtc ar« \| 1980 1 tabulated. Tba fMsiUlity of a I Science of tae Total I kallstic. ao-«asa policr for kair j Znlra>Mat 14:53-75 I aaalTals la entllaod aad snppocted. 1 1 1 1 ff«TK; TMCt SIEKZtTS; Ha»: I \| JCSTBU.I1; 8USOIERER OTISODS: I \| CZTUS; fSOItnS; COMPUaTITZ \| \| HllC»TIO»S; 1IDRXJVB; »IT1BOTT: 1 1 nsntic; EuivH: BBCRTIE; citBian: i 1 cueing cBiCBiii: CHSoaitui co ant: i l ccrecs? sjiiros: sssniliiB: eon: i 1 ICDTIE: ttoi: nrrmiuB; LI»C; i 1 B»a»isns: BHGIESE; SIBCOSI-. i ( tciTBDEni; ncKn: EBOSPBOSOS; i i tcmsios; iminitjii; SSLHIOI; i l stiicoi; sum: SODIUS-. snctrioa: i 1 SOITOB; TI«: Tninm: TVISSTM: i I IIIC; tltcomH I i i tvm •««> NJ O S3 ------- YitaBltS TMO-J2-S II 1W 47.99, HP 1677 C, 3277 C, vp 1 M Bg at 21M C, 1O M Eg at 2MO C (COimiTED) TISSUE Ml 2 Beart «S13 KUner a5H liver posiitt tarns itumcaL RETROD a Wat. BOBBSl OF GUIS 4 2 ) 7 b) 2 ml 11 •1 •< h) » I1ICB < or » 1.1 89/9 f"* t) •one ietected a\| < or » 3.5 119/9 (vet vt) b) lone detected •t) b) lone detected iin i 6>UML XEromTiokT I i I 0.28 * or - 8.55 I •) Bales 9/4 \|ve>t t) 1 t) Peaales »on« a«tect«a i I ftoi a »ro«r of <1 antopsi««. 1 forensic •edictl «E»iiatieH, Japan. 1 Baits, wan « a«a «0.« re. r«««les. 1 f«aa aq« 37. jr. \ I fllCZ IL1HMTS; 1OTOPSIES; JU»; \| H. ------- Iital» 7»W-3V« 11 Itl «7.tO. HP 1S77 C. n 3277 C, TP 1 aa Bg at 210 C, 10 n (9 at 2«to C TXSSBI 114 t 1... Etposau toon 1 IIUTTICU Btnoo n I t (SIS la Buelo 1 1 ( f 1 1 t 1 1 1 1 t 1 f 1 ' . « 1 i «st7 i I n 1 Paacroa* I I 1 1 1 « 1 1 t 1 1 1 1 1 1 1 1 1 BKMEt Of CISZS a) 2 •» 2 1 1 a) S b) 2 Mitt a) < or - 2.7 »?/9 (Mt Dt 0. 60* 1 S ag/4 (vot vt) a) oa« J»t«ct»4 i) < or • O.CS 14/7 («t i Biti i CEIIUL xiroiimo* i XERUICE 1 l l < a) 1. a * or - 1.» 1 a) Balaa \| fakan, B. tg/y (nt »t) I t) rmalas 1 Suaki-TaavBOta, B. M 7.8 + or - 10 tg/g \| I IBMO, I. (»«t it} \| Feat a groap of 61 actopsiaB. ( T»rai, B. 1 foraaslc Badieal «aalaatlou, Japan. I 180 \| lal«B, aaa ago O.C Tt. rcaalae, f Irehlnc of 1 a«aa aoa> 37. a rr. I EBTlroBatal Boaltk 1 1 35(1):36-«« 1 ntCE ELtBtns; tBTopsras: Jirti; i \| linXI9B; IfSElIC; CUHIB; COBU.T; 1 l cnoBioB; ccmi: XKIB; sttcmr: i \| I1NTIB; BKBESIOB: BIK1IESB; \| \| iHBIBIBS! IHXBOlts SCMBIOfl; \| l smiXBB; trnixm: TIIIBIOB; UK; i \| SCLB; SBOBIBt: UTR; KBIEIS; \| \| CtlUBIB; CtiraELLOB; BXHT; BffSCLES; I \| PtKIMS: SPIEXB; 1OTSS; lOKTt; I I BETUS; CO§PU«TITB BTaigitXCtS; 5BI; 1 I FOEBSIC BZeiCXIB 1 < 1 1 1 al roao aotoctod I a) Balo \| Takaaa, B. ») 0.08 + or - 0.23 \| t) roBala* \| Saxakl-Tacaaoto, B. 1 Iroa a groat of ft aatopslaa, ( Taral, B. t faraaile BOdleal axaBlaatioaa. Japaa. 1 1980 1 BalaB, BOBB ago «0.« rr. rcaala. I Ircklna of 1 aaaa ago 37.a rr. \| EBrlrauoatal Malta 1 \| 35(1}:36-M 1 TIICE ELSHEBTS: iOTOMISS; jaral; I I »inBiim: IBIEIXCI CIBBIOB; COBUT; I 1 cnoBiira: corrEt: xioi; SEBCOBT: i I MBim; BietESIOB: B»ISl»B5t; \| l loeiorjg; atrxBoiT; SCHBHIB; i t tiannt ixmxm: THIDIOB; IXK; i I eOlD; raOBXIE; UTEB; CIDBKIS; I I ciisiKn: criESEtins; asm; HOSCLES; i I MKXHS: SP1EEI; LHBBS; 10IT1; I t BRalSi CORPIItTXfE iritOHIOUS; SEX; \| I rcmsrc BIBZCXII i 1 1 a\| < oc - 7.5 ag/g (>ot a) 1.3 + or - 2.2 a) «at« I TBka«a. B. »> «J/g (»ot »t) t\| r«a«l«« \| sazakl-tasuoto, B. b) < oc * 3.7 ag/g <««t •) 1.9 » or - 2.6 \| liana, t. •t\| eg/g <««t »t> Itoa a groap of «1 aatopslos, 1 T«ral, B. for«a aea 37.4 rr. \| E«TiroBB ------- TltaalM 7UO-32-6 Tl It* 47.90. IF 1677 C. TP 3277 C, TP 1 M Eg «t 21(0 C, 10 •• Sg at 24»0 C fCOKIISEI)) TISSUE 4S1t SBlM* iinsnx BOBTE 1UITTICIL SET HOD SI mm OF C1SIS »» 5 b) 3 11WSB . ») < OX - 4.2 «J/9 («et "t) b) < or • 6.* «g/g t*t •t) Bill a) 1.8 » or - 1.8 »9/9 !•• »> b) 2.1 or - 3.7 •9/9 (••* »t) EHttU IBTOIB1TIOI a) Bales t) f«Ml« riot a.qcoip of 61 nrtop«i€«. forflasic atdical ezaHlaatioot Japan. Ral«. •••• af 40. C TT. F««alea, •tan a9« 37.4 Tr. ttaCl niailH; aROKIKS; J»i«: itmnns: iiswic: cuncs; COBILT; CtBCSTOH: CCR11? IBO1; BIBCTOT: HEitn; BESIISIOB: meansi: iimivt; iRUoiT; SCMOIOI: siiiiiBS: tiTMiim: muiaB; sue; SCH; MOIIII: LXTSB; KIBIETS; CEtlBSSH: CIBffltlLOl: RS1BT; HOSCtSS: I11CBUS; SIIEEI; LMG3; IORTI-, srriLS: coaeuaTXTi srixoitiois: sn; TCttlSIC HIEICIII BI7EEMCJ Tnkava, B. Suzakl-IasoBOto, a. llano, I. letai, B. 1980 trckiraa of EOTiroaaeatal Health 35 ------- lolvene (8 CI) Benzene, (ethyl- (9 CI) 108-89-3 C7-BS HI 92.13, HP -95 to -94.5 C. BP 110.6 C. IP 36.7 u Hj at JO C (COBTIfVSD) TISSUE 4521 Breath EXFOSHIE BOBTB IIU.TTICU BSTSOB SC-BS HOHBI5 OF USES 54 (387 samples) Bluer lot given •Ell 9.0 ng/1 Geometric G1IEB1L IirOSBlTIOI teasared at 25 C and 760 mm Sq 100* occurrence tome and op pec one-Sign Units 4.0 and 17.7 ng/1 aealthr. 18-35 yr old, aoasiokiag. orlan blacks and caacaslaai. Chica^Ov IX. Higidlf controlled €lp«rlaental conditions. B811TB; 1XCCBQLS; HttBOIS; 1D51TS: CBIOEIIJTM imtOUBBOSSi »OUTHE CBGllIC COBPCO«BS: HB1LTH 1121805; iiBiUTioi; arriBOLiSB: BZTAEOLITES: Ecpnmrow imsvtE: VBBH mis IEFIE5HCE Krotoazynslcif B.K. Brnnean. G.B. C' 10 ill. S.J. 1979 Joarnal of analytical Taxicoloar 3:225-23« Iala«na-2,5-clla«ii« (I CI) 1,«-BrazeiwalaiiM, 2-aethyl- •f-TO-S C7-B19-12 il 122.17. ITF S* C, B? 27* C CI) tissiri 4522 urin» IIPOSUSI Botns 1 1 1 1 I miTTICll BETBOD I BUB3SS f OF C1S2S 1 I B1ICE I 1 BE1« GUIB1L IIFOBBlTIOf (•Tie. local and sr atomic effects relating to hair dye floravlation. iaqcedient tests and experiences in •ae and aflisals. tints: Dis!»TTTis: IIOPIISBS: asiKE; II TITBO 11ILTSIS: IB TITO 1B11TSIS; BFTIB"! DIES; CIBCIIOGSIT; COSHSTICS; GIBETIC fFFICTS; BE1LTS HlItBDS; BITJ90IISB; jrrilOLITSS BEnSEVCE Karzalli, F.I. Sreeo, s. Haibach. 8.1. 1978 Journal of CaTirOBMBtil Pathology •ad Toxicology 1! 50 9- 530 Tolaener o-nitro- (8 CI) C«Biena, 1-iethrl-2-Bitro- (9 CI) St-72-2 C7-«7-»-02 BI 137.1, BP -4.1 C, BP 222.3 C, TP 1 •• Hg at 50 C IISSV* »5J3 Breath ElfOSVBE BODII jtmniciL BETBOD SC-BS BOSSES or CSES s oa? siaples) BalSE lot glren BE1B 3.040 s.g/i Seoietric Gr»iB»l IIFORBATIOI Ceasnred at 25 C ad 760 •• Bg 1». If accarreitce Io»r and up pec one-Sigia lliits 0.017 and 0. 139 g/l B«althT. 18-35 TC old, non«»okti. nt tan blacks aad caacisians. Cbicatjo, 11. BioldlT controlled eiptriaaatal coiditioas. lE»TB; IICOEOI.S; Illliois; units: CttOBKMID HTDBOCIBBOBS; TOLITTLS CBG1BTC COECOntDS: EE1LTI BllattCS; 1IBH.HXCB: BETtBOLISB: BE11IOLITIS; ECPUL»TIO» EKMSmE: BSBliB IKEIS IEF£1E>CE Ecotoszynski, B.I. Bcaa«an, 0.5. e'nelll, e.J. 197" Journal of Inalytlcil Toilcology 3:225-2M ------- Total BBC (la porttaes in CS-BS-O.8 n 290.85 nssn »52% Blood •525 PlaeeBta 'IPOSOBB BOUTB IBUTTTCal BBT8OD sc-BC CC-BC 1 mass OF CISBS a) 25 M IS e\| 10 a\| 25 b) IS e\| 10 laGB a) 18-85 ppb 1) 62-16S pp» e) 105-550 ppB a) 12-53 ppb b) a 1-1 05 ppb c\| 31-134 ppb BSaB a) 52.5 or - IS. 2 ppb bl $3.9 « or - 22.6 ppb c] 20». 2 » or - 141.2 p^ib a) 2T.2 » or - 11.« PP* b) 62.3 * or - 13.4 ppb c) 90.7 » or - 31.7 ppb fiBKBlL IBFOBimoB a) Coattols, fnll-t«ra pr«?n«ncie» t) Pt«-teca pEegaaades c) SpoataaeovB ibortima at laaa than fl vie EaaltliT* aoa-^xposedf prvqnaat voa9ii. ages 18-32 yr, tadia. IBCIt; IBOETIOI; U1ITSS HIOS; HOOD; piicim: coniiswni HUUTtOIS: CHLOBII1TED «T9tQCMBO«S; CEIOBIII O561IIC CCBP00B9S: KSECTICIDBS; PISrtCIBIS; ttsticioi Eisioais; POIOI.KICI IIJOS0BB; PIIGBIKT a) Controls, fall-tera pregnaacles t) Pra-tera ETeijiattCies ci Spoata&coaa abortions at less tSian 3 >k (inclndaa fetas) Bealthr* Boa-exiwaad. pregnant itoaan. agaa 19-32 ji, India. IlCIl; IBOETIOI; UILT3; FIUS; ttltuillOKS; CBlomilTXD BIDMCUBOIS: CH1OEIIS OB611IC CC9KOIOS; lISICIICIIESi P1STICIDIS; PISTICIDI BtSIDOES: POPDLllIOS ItHSDlB; PBIGV1BCT BEIBBEBCB Saxena, B.C. Siddiqil. H-K.J. Setb, T.D. Krishna Harti. C.B. Bhargara, I.E. KattT. D. 1381 Joaraal of lualftical Toxicolo^T 5:C— 9 Sa-xena, B.C. Si-ddiqti, 9.K.J. Seth, I.D. Krishna Bortl. C.B. Bbanjara. l.K. KottT. ». 1991 Journal of Inalrtical Toxicology 5:«-9 K) VD Ictil rot (lo paaUiiqs In CRHIIICI. '9-M-3 C1»-B»-C15 B< 35.50 iisstn »5» Utpow IIPOSOM BOOT! IHinlClt nrraon ITWBTB OF CISIS BtVGt BMl «I1IB1 IIFOBH1TJOI B«»ie« Iipooed persons la the United States, tfe« «»tli«rlajiis, SxnJati, Israel, Japan. OSSB, Polanl, Servaaj, laiia. Ellqacla. Pklstam, listrio. Eipott! «a««» at liTpettemlsa, e lava ted satoa cholesterol^ abaoraal •tea, oc iafaltaaat of Bcncoanscnlat fvtctLoa aftac acnte «xpoa«ce to eoabinatloat of pe»ticilea, tat mast data ski" DO alters* «ffecta after loaorteEH occnpatioaal ezposate. insruri: ITUGUX; ctsBini; IIDU; ISHBl! IIP!: IETBSELIWDS; PISISTII; ICL1ID; BDSSIl; Stntf; nllTID Sims: IBIPOSE nssni: BLOOD: BIOOD ffllSfia; 5ICCD SlSHi: KtTIBSOCTTES: nvKocms; eiu; VBIBB-. sinis; flll-H B1Z1BCS; OCCOP»TIO«I1 B1UBDS; fcfiimo* iieosoi: IBTEEZBCE Oeichaann, V.B. HacDoaald, I.E. 1977 Vcotoxicologr aod Enflroaaeistal Safetr ljM-110 («!IT PUS El ------- lets.1 >DT (e postieqs U cmttnt. 50-29-3 CU-B9-C1S II 3S4.SO (COfTtWOZOl 1 1 1 t r r i i i i IHJB1 •527 imlotic flald •528 Blood 1 1 1 raposun IOOTE t isaimcu Bx-YHGO OC-EC i >SM I I Blool, \| I plassa 1 1 1 1 1 1 1 t 1 1 1 1 1 1 1 1 1 1 1 or cuss 50 20 suet O.S-26. ppt •\| lot oirsn b) lot gives Bill \| GBIItll IfrOtimOI \| HntmCC 1 1 1 • 1 1 23.83 ppb \| 3 positive ipeciseas I saxea, B.C. Seoaetric I 1 Sett, I.D. 1 reeosaat meo» sisilax ia f Bahalaa. P.I. \| ««cioeeaoic level a»fl dietary t 180 1 bablts. Xo occnpatlosal or 1 lateraational Joarnal I acclaestal eipossre. lockvov, India 1 of Eoviroisestal I I analTtical Caesisttr \| F1SHCIDBS; CBLOIKUS9 HT9IOC1XBOTS; 1 7:Z«5-25» I CEIOJIBJ CICIRC coapooiis: cop; 001; i I en; unit: HBGHICT; «B«IOIIC i 1 iioiB; mcmt i i \ 1 fevlm I Delckaaim, «.«. 1 1 BtcDosaU. .t. I Opond persess la tke Halted States. 1 19TT I tke •etaexlaids, S«e4e>. Israel. 1 teotoxieolotr and I Japan, VSSI, rolaad, Oereaaj, lodla, t EnviroaMatal Safetf 1 Bulgaria, Paxlstaa. laitria. 1 1:89-110 \| 8«Fort«i eases at trperteaslas, 1 j elevated seru ekolesterol. abnoraal I j M6s, or ispairaieat of Besrenflcel&r 1 j fMctles after acate eipoaara to 1 1 cosbiaatloBs of pesticides, bat sost 1 j dats skos no adverse effects after 1 I long-ten occapatioaal expossre. I I 1 I KST»U: BDteiiii; eniiii: acin i 1 isian.: J»P»I: nitnims; tuzsttts 1 I idiHi; snssn: SKDSi; mm i I STH»S: IDIPOSZ Ttssm-, twos; ILOOD i i ztorocftes; ait: viat; iifisi; ' i \| EMITS B1X11IS; CCCIPJlIIOIU. R1IMDS; 1 1 tcpratno* Mposait; SSOPLISBS; i 1 flSTICIOIS; CHLOEIBI OIGIIIC 1 I CCBPOBIOS \| 1 1 1 1 a) 38.18 ppb 1 a) Ixposed I BichrdoB, J.I, b) 6.69 ppb 1 t) coatrols 1 tell, J.I. 1 1 SaBdlfer, S.B. I 8g Croa Soatlt Carolina Pesticide 1 19T4 1 St>o> exposed to slxtare of CDT, I F»rltoae»rtal 7e search 1 patatkloa ail carbaryl. Controla. 1 9:290-29 1 with so knevs pesticide exposure, I 1 tatc««l «itk exposvl aroip fox aie, \| 1 race, sex at. 1 1 < 1 slqaif least correUtioas of tot 1 I elevatioa asd ckoliaestersse 1 j depreaslon vitt elerated svatollc and 1 1 dlastollc blood rcessares. j I 1 I SCOT* cMoriii: IMOB PUSBI; DOT; i 1 flSTICIBSS; BZI1BOUSR; OCCDPaTIOItt I \| llfMDS 1 1 1 VO CO ------- total BDT do pacttio* la CI1BLIH}. 50-2-J CH-W-CIS (1 35.59 TISSVt 530 laofl. •S31 Hacctta mason torn lxa»-t-toMMl tie RMsm ion RCTffOD ac-cc IDS BIS OF CASKS ppb 200.91 ppb Go ow trie esitui lipowd pcncas la tk» ttitcd States, US. Filq«rl«, Patlitn, lastci. l« portal cas» mis ------- 1-TTTPtOpaaB, <350-«9-8 C11-B 12-12-03 •« 220.22 S-fcrdrorr-. I- (8 cq (9 CI> TISSUE • 513 nood. plasa* EIKSnBE 10OTI IlJeetlOB inaestloB 1I1LTTIC1L BBTWJB •PLC Flaoroaetry BOBBxa or ctsss 5 BU6E a) 2.3-0.29 aioles/T b) lot gir«n cj lot glvea d) lot glea «) BOt gives nil al 0.97 » or - 0.068 naolea/1 b) 3.25 naoles/1 c) S.SO taoles/1 d) 7.81 uoles/1 e\| 11.00 moles/1 GJMBIL mroiuiioi • 1 lBlti»l •«aaac««««t and 9 hr after 24 (in IT of 0.908 iwiles/lcq. tiexpowntial decline. leai is 9 hr tiM-average 11 50 aq doss c) 190 «a dole 4) ISO •? dcae <) 200 mq doee b)-a) 8 ir tiae-arelsge a«ias c»pited fro gcapkie at«»-»n4«r-t!»-ciirT« data aftec oral dose/* ar H-S2 TC aide, t 52-»6 k«, nitk ifocloiie disorders. asea. rorltlag CBves; BBUS TBEIHT; mvo ICIDS; iioao Ptisai: lEtraososctniR iisnsis; leans; DIIRUK 1EFEBEIO! lagaissea, I. Ilelsea-Kadsk. F. 19BO Acta Paaraaoologica et Toxlcolojica «6: 257- 262 Tvnvsten 7»»0-33-T It* 183. 85. HP 3«IO C. BP 5900 C. TP 1 •• 19 at 3980 C, 10 •• Hg at «90 C 1 IISSOI \| EtrOSDRS BOOT! \| IHtTTIClL \| KOBBIB \| EitGE \| BB»« \| 6EIZBIL HFO8BJIIIOI 1 I 1 HETBOD \| OF CIS IS \| j 1 1 - 1 11 1 1 t f 1 g 1 53' II II B€Tlew. 2« npreseatattve 1 "air \|\| II cie-aaalrsls treataeats arc II 1 II tabulated. The feaxibiUtT of a II 1 II holistic, ao-vash policy for hair til t aaaljrls ts oatliael aad supported. Ill II III 1 t tiriSV; TP1CI ELZirEBTS: HUB; III il Ktsmtii: Hzis«E9en HBIHODS; lit \|\| FITILS; P SOT IMS: COHPlBlTlft 111 II IflI01TIO«S; ItaniOB: IBTtHOlT; III 1 ISSEIIC; BIRIDI; BBOirJS; CIBSITC: 1 1 1 1 I ClICIOI; CIIOBIIE: CHSOHIOS; COB1LT; I 1 I 1 terra: SHIIBH; sBsmnirs; COLD; 1 1 ICBIII: IEO»: L1ITI1BDI; IE10; 1 1 BIOIISIITB: BiRGiiEsi: iiscosr: 1 (ClIBOSIBB: HCKrt,; IHOSPSOSDS: 1 ECTaSSItlR: BDBIDIJ9: SBXEIIOB: I silicon sinra; SODIOR; SIECITIOJ; 1 sin FOB: TI>; TITIUVI; TDIGSIIB; 1 ziic; TiBCOBinn f i {BEIT PIGS] BMI IBS C! Caittlebocoagfc, G. 1980 1 Science of tie Total 1 EETlcoaaent ia; 53-75 U> o o ------- Illgstm 7440-33-7 * lt¥ T83.IS, IP 310 C, BP 5»00 C, TP f » Bg at 380 C, 10 II Sg It 4490 C (CORIIIBD) ixssm 453* KlSaeT 4S3«> li»»r 4M7 MWI fosvn toon iHlTTlCAl sntoa n » DBBD CaSSS e i« S 19 ) « b) 1» 1 1 MISS < 0.003-0.005 v?/9 < 0.003-0-018 «/« t «t 1 < 0.003-O.OM oq/q I < 0.003-0.01* 09/q •t wt •) < 0.043-0.011 09/4 b) < 0.003-0. 15 ng/q let lit iHi i sBijiai iiroMaHoi t ssnstics ! ! i i >t gl»B 1 •) Co»trol« 1 Br«i«. D. lot SiTO 1 V> lotlnts. groups I aad II 1 lorlb«ra> s. 1 \| vester, P.O. 1 t«c«s«l refiBcrr »»« aaeltar 1 1980 I «rt«rs. a»«« 55-7S jr. siposed to 1 Science of the Total 1 lurr Mtls 1-3 a«c«d«a. 11» 1 ICTiconwat 16:13-35 \| ltt««» catlm«t i Amtk 0-1.S yc I \| 1» qconp 1 nd 2-19 yc. ?rfl«F II. I \| Controls, a?«s 43-72 Tt, (to liwd SO 1 1 k troi th« f«etorr. 3>«d«i. 1 t sum: cimtiBS; Kioirrs: IITIB; i 1 HISS; cospiiiTin snigmois; I i iimSTSiit ixeiiRt nasnumi i I inwus; niiBOii: usnic; I t mumivB; c»BBJ0»: css:q»; csBo«0B: i 1 CCIU.TI cotni: GOU>; noi: i i iiiTnm: tuoj lurainss: nicnsi; t 1 KinDBflfl: fBOSPBOIVS; IVIXDIOB; I 1 sciiBius: SIIMIBS: SIIVEB; ni: I I ivissni: line: HUITH BKIBDS: i I J1BB3TSIU JUITS; SBHTM3 1 1 !_._. _ 1 1 \ lot 9iY« \| t co«toli 1 Braea, B. ) lot 9ii«» 1 t) laxkers. groups I »»4 11 1 Borlbcrf. 8. 1 1 l«st«r« P.O. 1 t«c«»»4 r«f i»err ••» «Mlt«r 1 1980 I ictlmrs, ««•« »-7« rr, expowi to 1 Seine* of tie Total 1 kMiT Mtalt 1-3 awnfla. Ii»« 1 rn»iron«e«t 16:13-35 \| t«twn tetim«t w4 4«»tli 0-1.5 jr I 1 i* qroip I »4 3-19 IT. group II. I \| Cotrola, «9« 13-72 rr> »'"> liwi SO 1 I k* fxoi tk» tietorr. SvelM. 1 1 t 1 SIZDMt C»»>«SS; Utinsj 1IT5BJ \| I itics; omrumn miaiTiois: i I mvstiiai iiaitis; asaSDiiinr i I CKBC9S: \irimn; usnic; i I ttwniaa: caDangi CISIUB: CRtonvi); i I cceiLt: comii SOLD; noi; i 1 laming: »u>; si»s»«si: HMCOSI: i I tctnosmn! uoswoiust BOBIDIOH; i 1 5cmim; SHMUJS: sn«i: TI»: i 1 t«iesn«: IIK: HUIIH BIZUIS; i \| IlDOSltlal Pims; SBBITB! 1 > 1 a) lot 9lT«n I ) Control* 1 Bran, t. t) lot alven 1 t) lotkets, o lima 50 I t ka froa tk« tactorr- Sveiea. I 1 1 \| SKDEI; C»»IES: (ItltTS; 1ITSS; \| t taies : coataUTin r»n.uiiio»s: t I IlCDSTBIaL BTSIBIB; aEaSOHIinl 1 1 BtTBoos: UTUQH: »snic: i 1 Ttmrans; citRios; cssrnB: CBBOBUJH; \ 1 cciui; COPPIB; SOLD: isoi; I I tllTBlim; ItaD; 141MIES2; BMCTIT; \| 1 sciTBOMOB: iBOSptoms: BOtlBias: 1 I SCalDimj SI1NID1; SILTE1: nit; I 1 tnisaiEi-, me-. BUMH aiiisis; i I iBovsniti IURS: SIBHZIS i i i ------- mulu 7MO-61-1 I Itl 238.029. IF 1132 C. B 3818 C. TP 100 n 8g tt 3270 C IISSJS • 538 Satr HMSBBE iOBTB • B1LTTICU HSTBOft n man or cisss 5 I1I6E 0.25-10.4 ag/g mi lot gin* esiiBii iBFOBBinoB Eilk hair sasTlB* lector* exposed iateraltteitlr to aiaalea at the laxtraliaa atonic E»rgr Co»»isslon eeacck establishment. iBsraiixi; Bin; ramos; BiisnnBnr MXBOBS; OCCBP1TXOIU BaillOS; iiBXOfoctnis: iBw>5T»i»i aioiii! BEFEUBCX san tier, <•'• vrtt, J.B. 1»60 iBTiroaseatal Besearch J1:»07-«15 VaaaUas 7»»0-62-2 T Itl S0.9«1«, Bt f»17 C, 3000 C. TP 1 •• Bg at 2290 C, 10 u Bg at 2570 C 1 IISS1S 1 BXfOStm BOOIB IMLTTICIL IBIiffl 11T6E 1 I BRHOD OF CtSSS 1 1 1 TI1CE tLHIBIS: 1OTOPSIKS; J1P1B: IIDBIBVI: ItSIBICi ClSniTB: COB11T: CBROBMB: COPPEB; iao«: BIBCOIT: IIBID9: IllSIISIOB: B1B61BISB; IDEUIQI; 1BTIHOBT: SC1BDIOR; SfLEHIBa: IITMI09; T1MDHJ9: flK: SC1C; BIOBIBZi IITSB; KIBIBTS; CIIIBiaii ClHBHLOBi HEIST; SDSCLIS; F1BCXI1S; SFIIBB; 1VBSS; 10II1; BII11S: COBFIUTITE ZTlt01TIOB5i SEX; FOIIISIC BEDKIBE Siblects froi 17 collection cites IB the o.s. SIIBBIBB; BCirBOSTOB; TlBlDIOB; EIOOB; SSI) SOUTH DlKOTtj III TOBK; ITCBTBC; BOBT1B1; OBIO; BISSI5SIPPI; \| \| THIS; BOBTB D1KOT1; 11SHUGTO1; a) Bot given b) 0.0-9.33 og/g (»«t •t) c) 0.03-0.23 ug/g (net «t) it 0.10-0.31 ag/g (vet •t) \| CIllrOBJH; IB IIOH: ISDIIII; \| ICOIStlBl; 1BE1BS1S: TIOBID1: t 1 riBBOBT; TMCB CIBIUTS a) 0.11 * or - 0.09 \| a) Bales, eoEebcM. 9 sableets ag/g (vet «t( I 1) Faaales, cmkmm. 2 sabjecta b) 0.18 • or - 0.21 \| c\| Bates, crebella>, 7 subjects "9/9 Cet t) \| d) Feaales, oerebellas, S sol-)ecta c) 0.10 * or - 0.06 1 og/g (cat t) 1 Itoa a group of 61 aatopaies. 4) 0.20 » or - 0.10 1 forensic M4icl ezasiaatiois, Japan. •g/g (net vt) I I 1 a 1 ales, aeaa age ao.S yr. Pesales, eaa age 37.4 rr. 1 tElCE niBtlTS; IIROPSISS; J1P1B; t IIBBIBTIB: JSSEIIC: ClDalOB; COB11T: 1 CBBGBIOB; COPPBB; ISO: IIBCDXI: 1 iBcint; B16BISIQI: BIBSHISI; 1 latlDIQB; iniROBT: SCimiB; t «IIJ»IOI1: TITMIOB; T1I1DIUS: II1C: 1 SOLD; B30BJ1I; 11TSI; KIOBtTS: I cisiBsns; CSITBILLUI: BBIBI; EDSCLIS; 1 menus; spiral; LUSGS; icm; l i niLS: CO«S»I»TITI ITU.BHIOHS; SBI; 1 T01IBS1C BIBICIK 1 EFE1EBCI Tndan, B. sazikl-Tasaaoto. B. Icaio, I. feral, B. 1984 Irciiies of BBTiroaaentll Bealta 35(1):36-» lllanaT. I.E. Kobota, J. losee, t. Eotb, n. 1968 ircalres of EnvlronsaBtal Health 16:3>2-3«B nkavav B. nznki-TaSQioto, I. saoo, X. erai. B. 980 rchires of EsTirotuatal Bealth 5(1):J«-»4 («« tkSS) o ro ------- faaafllaa 7«0-«2-2 BP 117 C, tl 3000 C, TP I an Bg at 220 C, 10 is Bg at 2570 C (COITIIKD) nssra «»j Breath MM Bair »SM H»lr W5 nic MSVIB tOOYf tUtLom tlURICM. BRBOD I n BBBBS i MKS i mi j ouiiu nroiimoB i IIRIZICI CiSKS 111 * 1 f 1 - - 1 114 1 1 lot gl»e« 1 0.7 if 11 siielrt at rat of 1 1/sla. 2-10 1 IfcselMOS. K.E. i \|\| ala after bsrsing * arc nltlng roil. 1 Desaedeleer, 6.6. 1 i i tun detection linlt. \| Johansson. T.B. Ill \| Binchester, 3.1. i \| \| BnlrersitT rhysies shop, Mariia 1 197« III 1 annals of Occupational i \| \| noiIBl; IBBIW: mini; dicing; 1 Hygiene 19:225-2J« I \| i caioBjBJ: ctaoaioas conns iiois i I i i mot BI let 1KB; nun.: Krtissiw; t I i i SBirm: iniHOH; TtuDioa: me; »i« i i i i tcumoB; imtst mvRim i I i i mosMHBS ; TBJCB niBiits i i i i • I I i » It 1 a) lot gim 1 a) ft. 04 + or - 0.01 I a) Controls, at blttt 1 eib»o». S.S. H \| b) »ot giv« I aq/g 1 ) »»ll-t«ri lo birthMjght, at I Dcvolf. I.S. 12 \| e) Mot glT«B l b) 0.0» or - 0.02 I tittk 1 180 11 I 41 lot glv« I «9/g 1 c) tr-e«tm. »t btctk 1 »mtrition B»port« It I •} «ot jlT«m I c\| 0.01 « or - 0.01 I 4) Controls, 3 ao 1 Int«raa.tloo»l 10 I f) not 9i»«a 1 •«/« 1 •! rnll-t«rs lo« Birtkmlgkt, 3 so 1 21(3) :3«1-3«9 I \|4) 0.«9 * or - 0.12 \| ft tr-t«rs, 3 so I 1 1 «9/9 1 41ans » ot - SIB 1 \| \| •) O.S» or - O.sa \| \| I 1 i«/g 1 Konatos In lallfal. fco-Mn froap 1 \| I f) 0.22 * or - 0.1* \| scan Urtfc«igkt H80 g. 24-3C rt I 1 I q/9 1 gcttetloi, l«ll-t«ri lo* birtbnlght I 1 \| \| group aan blctk «l 0.036 ng/g 1 b) Klti pie sderoala patients 1 Bolibecber. J. 1 I aeALans I Sasfles fron 7 scalp sites in each 1 Stuart, B.C. i i \| sabjeet 1 17 III \| Clinical Cbenistrr l \| \| CltlBl; JOB1TS; CltTUL RBTCOS I 2»(11) ; 1996-2000 1 \| i IISTH oistiazs: atn; uoBitoa; i I i i item; ciicnjB: cnion»: cop;»; i 1 i i setts Tooiit; BiiemsB: BIIU.SS i 1 i i sitinmit siiTiB: sonoa; soirtus i \| \| \| 11BUIVB; tlBC I --,,,-.» - ' ' ' III 1 j j j 1 rerie ef irarld literatue on the \| Jenkins, B.I. 1 \| I accaselatioa anfl bioooseeatratlon of 1 17 \| \| \| aelectea toiic trace setals in hsnan \| ZTl-«00/t-7-04. 14 1 1 1 hair «»4 nalln a»4 other saanalinn 1 pp. \| t 1 hair, far, nails, cla« and hoofs. \ I \| 1 Tabalated ri geographic area, I I I 1 aabjects, sex, age, exposure t I 1 1 gratiest, analyses in ppn, and I I \| 1 aathoritT free over 400 references. 1 III 1 \| \| \| IIIICl: lOSTIUIl; CMIBl; CIITB11 \| 1 i i mild; ruscpE: noun HST: «f i \| \| \| ttllllO; SOQTB UnlCk; SOITBEIST I I i t isii: oiRiD KIKDO: anno sims: \ \| \| \| 1111: milS; BETIEB; 1ITIBOIT; t l i i itstnc: BoioB; CIDBIOS; CIBCBIOR; i \| \| \| CQllM; CC??H; »»!; BCTCOBI; f l ii iicKBit snBinits Tilt Ti»ionnij KB i 1 \| \| rciirtiof: kilBii POTOUIIOIS; \| I \| 1 EICkCCOBIIkTIO; SIOIBBICkTOBS; tlfl 1 1 i i EOIIOTIOI; vopvimoB zxposni; un \| \| \| I tCItlTlOl; ISkCl HIMWISJ HITklS 1 1 1 1 « (Bin p»oi) ------- 7a»o-SJ-2 t it S0.9»i«, BP 117 C, B» 3000 C, TP 1 aa Bg at 220 C. 10 aa Bg at 2570 C (COIIXBOXD) I 1 1 I 1 1 ItSSWS •s»« Hurt «1«7 Miner 1 1 1 ( EiMsms loan iBimxcu. BBTHOD •1 it ( l l r i i i 1 1 I as« 1 » I Lira 1 1 1 1 1 f 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 imia or cuss a) M 2 •1 7 hi z l l 1 MISE ») O.Ot-0.1* ej/» (»et »t) b\| 0.21-0.23 ng/J Net «tl •1 0.08-0.22 04/9 <»•* «tj 1 lot glT«» a) 11 a) lot gl»«n b) 3 b) lot gitea I BUB i etiEtii xirotsAiioB i KTMBBCE ! . .» i i ») 0.09 « or - 0.07 \| .) Bales 1 Tofcm, 8. ag/g (••* «t\| 1 IJ Pnal> 1 S«Mki-raa«K>to, B. b) 0.22 or - O.Ot \| 1 1BUO, K. aj/g \|mt t) f fro * ?roap of 61 Mtop»l«», 1 T«r»l, g. 1 tactmalc ndical «»iatioi> Jap». 1 180 1 Bilu, M» •«• «0.6 tc. Ttralma. \ IrchlTM of I MU »« 37. • TT. 1 EDTitOlMBial S«»ltk 1 I 3S(1»iJ«-»» I IB1CI EltBIBTS: JUIOPSIB3; J1F»; I 1 JIDRWHI; 1BSXIC: C1JBHI8: COBU.T: 1 1 cBtonvB: coTTtt: »oi; BIKIBT; i 1 iBentB; BicitsiM: Bueutst; i l BVBIOITO; imBon: sciroioB: i 1 sntmii: TITUIVV: TIHBIBS; 2i»c.- i 1 C01B; BtOBIIf: IIIEJ4 nOIZTS: 1 1 CIltBtVB: CIHBEUBB; BBllIj IVJCLBSi 1 1 tiBcius: siiBBB; vnest IOBTI; i I B JlltS; COMIBlTira lTUtHTIO»S; SKI; f 1 MBnsic BinicHE t i i U 0.13 * or - 0.05 \| •( «»!•• 1 T«k««, B. •9/7 (••* •') 1 t) I««»l«« 1 Sunki-TamHto, a. W 0.02 * or - 0.03 \| 1 Uaao, (. »g/g f«»t it) I ttoi a qro«p of «1 »«top«l«», 1 T«r»l. B. 1 fomslc wdlcal •iaiDttio«a> Japaa. 1 189 1 1>1«, M** a«* 40. « Tt. r«ult>, 1 archive* af 1 M«a •?• 37- • re. t CTicaM«tal Bvaltk 1 1 3«{1):3t-M l TIKI rttatns; kmorsitst Jam; i 1 IlgBTBUB: IfSniC; CIDBIDBI COHIT; I 1 cnoaius: ccrrsBs r»o»: BMctar: I 1 1BOIOB; ai«BisioB: stieitist: i 1 IOBIDIDR: IIIIBCBI! SCUDIDI: < I 3nmvi: TITIVIOB; miDloB: intc: ( 1 eoiB: gtoiiM: urn: HDICTS; I 1 CI1BBS3S: CSinilLIB; 9U11; JUSCltS; t l imctMS: sriitc lotss; »OMI; i 1 «tI«lS: COBMB1TITZ ETIIOMICM; SEI; 1 I 1C1IBSXC SJOICIH I ' ' a\| 0.12 » or - 0.07 \| a) Bal.a I Tnk«»«, B. nij/g (>«t «t) I t) !>•»!•> 1 Sazaki-Taavaoto. B. b) 0.09 • or - 0.12 \| 1 »«mo, K. ua/g (vet vt\| 1 Fcoa a gcoap of 61 »topi<», I tecai. B. I fcreasic aedlcal ezaaivatioav^ Japan. I 19BO I BalM. aeaa age «0.« re. r«Mles. I lzeki« of \| i«a» age 37.4 Tt. 1 iBTiroueiital Health I I 3S(1»3«-a \| II»CI ntBEBIS; 10TOPSIES; JlItB; I 1 iimBiB: Msraic; ciosioi: COBU.T: i \| COCBIDB; CCfPZt; IJOI; BllCDIX; 1 I IICKTR: HteilSIVB; B1BS1BISE; 1 1 loexottn; amioti: SCHDJBH; i 1 srusins: -ritinoi: T«»IDIO»: inc; i 1 60I.C; BtQHUf; IITEH; KXDKTS; t t ClBtBin; CniBEUOB; HX1BT; BOSCLKS: I I IIBCMtS: 3UEB; IVBGS; aOllii 1 i B1TUS: COB»UMITS CTHHIT1OMS! S ------- 7««0-«2-2 T Btl <0.9«\|a, m 1917 C, B? 3909 C. T» 1 aa Hfl at 2290 C, IO M Hg at 2570 C fCOIT»1)ED) ISSBB 4M9 IM »SM Bvael* »5S1 111 wstws ionic 1 i 1IU.TTIC1L reraoD man r CISBS 2 j > • ) 8 I1KX 0.10-0.24 ng/9 (nt 1 0.08-0.09 »9/9 (wet ) ) 0.03-0.22 ng/g (mt t) ) lot giT«n •HI I 8EMU.L nroiBlTIOB \| HFESEICE 1 1 1 1 O.t7 01 - 0.10 1 •) teles 1 Takata, B. q/g (««t «t) 1 t) T««»la« ( Snzakl-nmioto. 9. 0.09 » or - 0.00 I \| AMBO. I. g/g («at vt) I »to« • gro«p of 61 aatopsio, I T«rai, B. I forensic Mdlcal •xulutioi, Japan. \| 180 1 Kl«>, MU a« 0.( it. Mnl«s. I iccbl»ea of 1 MU »q« 37.a ft. \| loTltonMatal B«altfc 1 \| 35(1):3<-« 1 tucB iLinns: IDTO?SISS: JiPii; t I U»mi; IRSBIIC; CUIXTU; OOBILT; I 1 cnoBtM: coppisj not: nmR: i I IllIVB; HKIESIVB; BUGUISI; ( I BKIPtVI; iniROR; 9Cim«l; I I snnigB; tinsinu: nnoiVB: 7i»c: i I MID; B10BIM: LITIB; KIDIIIS; I I cHiBioi: cuKBEitoB: aiiBi: IBSCLES; i I fimtis; seuzi: 10193; lam; i \| BEtkIS; COBPttlTXVE ETU.01TIOIS; SCI; \| I fCSZVSIC BIBICIIE \| 1 1 ) 0. 12 » or - 0.09 t •) •«!" 1 tnk»a. m. vq/g {net «t) \| 1) T«al«a \| Saxikl-Tanaoto. B. b) 0.11 » or - 0.06 \| \| anno. «. aq/9 («et «t) \| Itoi a gtatf of f 1 »»topal«a. \ Tral. B. 1 fot«BSle wdtcal «iaaliatio>«, Japai. I 1980 I Ial«a( M«B 9* «0.* jz. r«ial«a. I Ircfciica of I «aa aq« 3T.a jc. \| lB»iron»«»tal Health 1 1 35(1):3C-«» i i«»cs nsims: amofsus: «ni; t I iiniinii: nsnic: ODBIOB: COBU.T: i I CJioamst coptci; HOI: BIBCJBT: i I iitioB; aisiistoa: uieiiuz; i I iiBioioa: iniBonr: sciiomsj i 1 siinnia t muna: TIUDIHB; trie-. i I eciD; BSOSIII: ixvzi; nniiTS: i \| Climai; CZIIBCUVB; BE18t; BV9CI.IS: I 1 tiiCBtis; spini; IOKS: iont; i \| AE1U3; CO^PIWTU! IT»10»TIO»S: SZI: 1 1 fciime BtgiciiB i 1 1 1 1 1 1 tnlm el wnia litvratnr on th« I J«ikls. B.«. 1 aec«»alatloi aa4 bioconcentritlon of \| 1979 I ««l«ct«4 taite tcac Mtala IB taa»n \| EPl-tOO/-79-0«9, 184 1 kale aa4 Dal la sad otbc aiaaalian j pp. 1 talr, f«rf >aili, cl»s and koofs. 1 1 fab«lat4 tT qvoqrapUc area, \| 1 abj«cta, s«x. aqe* oxposart 1 1 4cadl«Bt. aialTBos in ppa, and ( 1 aitkocitr fcca over too r«f«c«Bcea. i 1 \| 1 ItXICl: IDS! Bill »: CMlDl; Cllttll \ \ letllCi; SD10PZ; BIDDLE E1S1; III I I tittin: sooia iBCTici; SOOTBEIST i I »«»: DTI1TZD (MGDOBi OJTTED STIIES; ( 1 BUB: iiILS; tzTin; tmaoiT; I 1 itsmc; BOEd: cioaiaa; cajcnim; i 1 CCBIIT: ccppiB; izii; HIBCOBT; ( 1 iicKtLi snciruii: TII; THIIDIBB; ME i l iciimoi; nniL posoiniois; i 1 ticicco!iTiHT:o»: BIOIIDICITOIS; LIVD I 1 tciionon: rorotiitoB RPOSDBE: 9»tie i t ECltOTKM; TUCE ZLBBtRS: BIT 1 IS \| 1 1 (BEIT PlGE) " " o Ln ------- Ynafti** 7MO-«J-2 » itt $0.91, at >9i7 c. B» 3000 c, n i •• 14 «t 229 c. 10 u 19 at »T« c KSSOI a. 532 VaBCTMB •TMSBCT IOTE 1 IUTTZC11 B&TBU1* n I «s» n i j i i i i unit or cisss a) 5 b) 2 ) 5 M 3 met a) 0.06-0.15 19/9 I»«t •t) b) 0.11-0.23 «9/9 (Mt vt) a) 0.11 19/9 (»«l «t) ) 0.07-0.23 «9/9 [»at tl i i t t i i BI»I \| GEIIUt IirOIIinOI 1 1 1 a) lot 9lm I a] Ial«* til O.IT t at - 0.09 ( t) rntloB •9/9 (Vt »t\| \| I I Eoa a 4toav of 6t avtopfll3« 1 forisie Mdieal •xaaioatioaf, Japca 1 B«lr« •••• ••• ff.4 T'« 7>al«s^ 1 Ma* ao« 37.4 Tc. 1 1 met nsiins; inomss: JIPI: l tiosiuii; itsmc; cumm: coBiii: f cnan»i cofw: iiot mcntT; t XlrXOfl* R1€VX5HB; fltVGftllSB; i itznivit aniion; scinin; l sitnrvnu tmitmt nnoias; UK: 1 eciBj tion»: iivn: EIBIITS: 1 cmnn: cnmittii: ism: insais: I 91BC1H5? SflBHS L^VSS; AOtTft; I BETU.S; coiriiinn trttniion; an: I focnstc atcKiis i i a) O.oa » or - 0.0* 1 i\| Ulas 19/9 ("t t) \| t) rail<* 11 0.1* * or - 0.09 \| 19/4 (*t »tj I Itol i qto«> of 1 aitopsl*. t focmclc aedical •xaBlaatioM Japaa. j ••la« ••!> «9» 9. < rr. r«ail«« t i«» «»• 37. < rr. 1 1 i»ci tLBBtin: inorsiss; J»Mi; l itenioi; unite: cisiioi; COJILT; cncBim; cctnts i>oi; MKOIT: Mnoi: iinisiiii: uie»tsi; tOBTDHB: IITTMIT; SCMDIDIi SI1HI015 TIUHII9: TtlUIOl: tIKl citmani ctinuiM; EEIBI: BOSCIKJ; titoifis: silBCi; I.HK3: loiti; RItUS: CO1PIB1IIIE IflLVltlCIS: SSI; reimic neiciri lErnno Takaia, a. Sicakl-lamaoto, B. tauo, t. Tarai, B. 1 999 Ircklra of BiTirauatil Maltk 3S(1\|l3«-«* Yikana, B. laaao, K. Twal. I. 1980 IrchiT** of e&ftroiMital Baallk 35{1):36-»» CO o IIICT omrosRioi sitioai 01 I TISS1B 1 1 1 1 5M 11094, fllSll 1 nrosmi toni I i l r tnirricti I BEIHOB t 1 1 I iDaia I OF CASES ) 10 b\| 8 c) lot 9lT«l I (IMS ) »ot given b) lot 9lm c) Vat 9tr«a mi il 16.3 » or - J.» a9/Jl b) 9. 1 » or - 1.8 W/il 0] 52.9 « « - ».7 ««c« Ticttlf-ciloiie ttlttttzltlo, BO Tttuia 1 deficiency t) S«T«r« fretalc-calorl* talmtrUloi ui Titttin l aifidancy cj IcaltbT eettiol* ll>o«ri«bed Thai chUiron, aq«< 1J-60 to. Controls. Tkal children. •9«a 12-sa >c« jaM aodo«c»iK»>lc t«ctqro«»d M Mlxwrlfkvd. UlIllID; CBI1D1H: BIOOD PUSH; •wsiTioiit Bincitian: IOTSITTOIH B1S010MS: PEOTWS: TITIIII 1: III IS MS fBIZI»CI siith, r.i. Sasltlod, I. tliuugtal. o. tcltTHIE, C. Gooix, t.S. dlsnf s.r. 1975 iMticai Jottrml of Cllileal lutrltioa • iBj732-T3i (ISIt FtGZ) ------- ritatio J tt!03-57-« ntcr coMosmoi »nora en nvemmtn (COITIIITEBJ nssni - aS55 Blood. aorBB stposvn mm iiuRicai BETBOB tnsa, 01 C15BS UKS ) lot ji»aa b) lot giT«a c) lot glv«B d) lot giMB MM a) 28.5 » or - I.I a«/dl b) 27. « « or - l.» «9/dl e) 2».7 » or - 2.2 no/Si d\| 36.7 * at - 1.6 «g/dl (S.E.) GS1I111 XirOtllTIOf a) 102 Bigrait ekillni b) 5» boys fnw »> c) 43 girl* team a) J) coatrola froa ottoc «tidi«s 35.3* of •) k«d <20 ««/U }-n «o olds, bclo« 3rd pozeoatilo IB bt, lit, «d k«scj drci>f«r«BC«, cbildcoB of BexicaB-lBoricu far •OTkors. Controls, yona. tlldl«-cla« ekiUcoi, Colorado. TITUII 1; CBI1DHI: IRC; UIB; HOOD niSHl: BMOB SIKH! ccttnkmi ttitmiois: met it inns; COIOHDO nmncE Cbu. B.«. RaBbidgai, I.B. Baractt, S.B. Boats- Jacobs. B.J. Leu, K. elllospl. J. 1980 lB«ricaa Jootaal of CliBlcal Batzitioa 33:23«-23»» tine TI«0-66-« tl lt« C5.38, HP «1«.S C. BP «•« C, TP 1 n Bg at ««T c. 10 BB Eg at S40 TISSOB »5C dc«Bal alaBd a«7 lorta IfOSBK BODTI \| imTTIClL t BETEOB US 11 IOBBBS or ctsis 3 •U6B •) BOt 9lT«B b> 1«.0-32.1 aq/q nt «t S.1-16 «9/9 (Mt »tl •III a\| 25.8 ng/g nt ¥t b\| lot giw«B 11 » oc - S.C aoyg (••t «t) GBI1U1 IITO111TIOI a\| Berkot t) CoattolB Jaranaao »ork«r, ------- Tine 7MO-S6-6 In It* 65.39. BP a 1«. 5 C. BP 508 C. TP t » Bg at M7 C. 10 n Bg It 50 (CORIIOZH) t 1 1 1 1 1 1 tissfff i Biposras torn inimcu. i BDBBII i SIICB i HH I eiu'ux nroiamoi i nrzinci < amen i or casss i i i i i i i i i l «SM 1 lorta 1 1 1 1 1 1 1 • •55! ziood, calls 1 1 1 1 1 »S«0 1 Blood, 1 tlaSM I r i i 1 i i i I i i i I i 1 «S«1 1 1 flood, \| I plasaa \| i r 1 f ( 1 1 1 «5«2 Blood, plu» t 1 III 1 MS ») 1 la) lot gin* 4 a) 27.1 ag/g wt rt \| ) or*r 1 Byodo, K. b> 5 \| b) 11.9-2C.t g/g >t t I b) lot glrea 1 b) Cntral* 1 Saiaki. S. Ill 1 r»roT«. 1. 1 1 \| Jain*** ior««r, tS rr old, at 1 Bcskizaia, K. II \| client* FtodociBO Blast tor 30 yr. 1 1980 1 \| \| Diad at aaxillary and Inm caac«r. \| Xatvrutioul archives 1 1 \| Controls, 54-71 yr ell. 1 of Oceapatiotl and III 1 ziTlKMueital Malta 1 1 1 91(11; 1BXPO3I TISSOB; 1O1T1; SOBJ I «:t«t-I50 I i < aisioB: iBiii: cisun-Lna: CHEWOH; i I i i xiajZTs; HTM: WBSS8 ECSCLXS: I l i i HBCBHS: SKI; cBtonvi: carpet; i 1 1 1 BIT US: II»C; IIBDStBIll tiirfS; \| 1 I I muiTiai: cccvMTiam suiiDS: i 1 i i ECPOUTIOI inosnc i i i i i III l US 150 r ) lot oirw \| a) 18.7 * or - 6.1 I a) ZrytkrocytM. U I-« ao oM» 1 list I, T. 1 I)} lot iriMa \| ug/g Hb \| t) Irytkioeytu. 1C T-12 10 ali* I 1980 1 e) tot glrea \ b) 27.6 t ot - 3.6 \| c) ot jlT«n \| ag/g Bb \| 4) Erytkraeytea, 21 I1-t5 yr o!3» I Bedical Sciences 1 \| I •) >ot glrra 1 c) 37.* * or - «.« 1 •) Irytkrocytu, 52 ad:7-13 f 1 It) »ot J!T« \| ug/g Ib I () utakaeytM, « «-10 yr all* I 1 f f 9) < gi»« 1 4) 2.3 or - «.2 \| q) uakacytt. 1 alolts 1 1 1 1 «g/9 Hb \| \| J 1 •) «2.2 * or - 5.6 \| (taltky »abl«ct». 1 J \| ag/g Ib I 1 J 1 C) 0.093 * or - 0.022 I HIC; lOULTS; CBZLOan; J1F1I; 1 1 i noyio (B7) c«iia i amis: BLOOD PUSBI.- isTTSjocrris; » 1 1 9) 0.129 or - 0.03} \| ItVKOCntS: 1SE \| 1 1 ug/lO(E7) nllc \| 1 ....... i 1 i 1 1 «S a) 13 •) »ot 9lT«« a) 79.5 « or - 13.6 \| a) 1-« ma old I Ushl, I. M 21 b) »ot gt»«« n 21 c) av»t glT.a bl ».» * or - 17-» I ej IT-IS yr eld 1 Biroshlaa Jotrnal of f d) 52 «) lot gt»« «q/dl \| d) Walt* \| Rcdleal Sciences 1 01 101.0 » or - 22.6 \| \| 29(1):7-13 1 ng/dl \| Malthy aablccta I 1 J d) 9S.9 * or - 18.6 I I 1 1 na/dl \| TIIC; 1BOII5; CfilLDSIJ; J1P1»; \| i i mils s sioo c ntstn anttocmst i 1 1 ifwitocrTis: let i » i « i 1 1 a) 70 1 b) 60 1 t 1 1 1 1 1 t III 1 1 a] 54.3-131.2 ng/100 al I a) 91.2 * or - t.« t tt Coatrola \| Laanrya. I. 1 b) (0.8-1M.1 ia/100 al \| no/100 •! \| t) F«iJ«nts at follatfl area t Roela, B. 1 b) 77.2 * or - 2.1 \| \| Bernard, t. 1 04/100 al \| lain, uai aoc 2.3 yr, froi I B«ckt, J.P. f (S.S.J \| C 9* »iomt children 1 Clias, B.P. b) lot gtTi 1 ag/dl \| t) 53 boys fro* a] I Baabia^e, K.I. e) lot glT«* \| b\| 7«.3 » or - 1.6 t c) 1 girls fro a) I B»cn«tt, S.I. i) lot gtnn I ag/'Jl 1 4) control* fro* other atallcs \| Hoots-Jacobs, B.J. ( c) 7t.« •> or - 1.5 \| fypozlacMia (<6« a ------- I lac 7440-S6-6 Za lei «5.J8. tS 419.5 C, IP 908 C, TP 1 aa Bg at 117 C, 10 » Sg at S90 (conmui t TISSBB 1 1 1 4563 1 91004, 1 rlama 1 1 1 t 1 1 1 t 1 1 1 1 1 1 I 1 1 45«4 1 11003. 1 strut \ 1 1 1 ( 1 1 1 I 1 i 4S« t Blood. ( aeraa. I 1 « 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ( 1 1 t 1 45SS 1 Blood, 1 «ena t 1 1 1 1 1 1 1 1 1 1 1 1 1 POSBH IQOtS aaUUoa oestloa Inoastioa am RICH MTBOD s IS us (HIBSX F C1SSS 60 45 70 a) 260 1 260 M 15 b) 17 »»• 1 eSKBIt XirORBlTIOf 1 1 76. tig/too al I t) lesiaeats of Lleaa (But pollute! 85.7 si/100 •! \| area) 89.9 nf/100 •! I t) leaideat* of Bn«Mls (!•• onetcic I fcllvtal ar«») 1 c) Msltoat of Chaclsroi (control 1 it««) 1 Korean* vitfc aa acctmlatlog of C60 ir old. I t«ta««t« of the >aM areaa 35 rr. I l«lfi«i I I Birsiaa: mows; \st; BLOOD tnsai; I mis; c»ama: mo; BMC DEI: 1 Bfins; «ic; ttDvsniti mssiois: 1 iiDusrniii jcttntioij POPOLIIIOI 1 11SOSOSB; DBB» 1BEIS 1 1 Baric, irofil of healthy nblects. 1 Bastllm data fox tetenlalng ehaages 1 li Bitritional itatu fro* indastclal 1 {cod pneesitgg tctniqns. 1 I in XEU»D; u>m,TSi tens; xifurs; I HOOD ssunu: smij KIDKTS: UTIB; t Bill: ISTltl; DIRS; TOODSi SOILS; 1 TietitTiai; CURIOE; COPPIS-, 1 Biieinst: imis: TSICB Eirastts: 1 K1C i t &) 1.44 * or - O.OS \| a) Itanaai Citr. KS, karl-««t«r axea aq/1 \| t) Mans CltT. BO. ioft-»at«r area b\| 4.28 * or - 0.82 \| slwlflcantlj loner lenl cr<0.01) 1m aq/lg 1 kat4-«ater area. t 1 KS and no reildeata aatched foe a?e 1 (ceaa aaes 37 and 37.7 rr), MX, I Icaotn of resldeaoe, aarital aad 1 ccoooalc itates, occvpation, mtber 1 cf cklldrea. saoklaq habits, at. vt. 1 1 ta hacd-natec acea. «l«j«l£icwt 1 iicrease in brpeiteBtloa. ICC 1 akaor>alltl«t« aad bTPcroriceiia. 1 I tllStS; B1SSCOBI: aDOttS; 1 omnoTiscnm DISUSES: 1 Biintnsioi; BLOOD SHOB: t ccBMimvs mioiTiots: CIOIIOR: 1 cucio!: CEBCBIVI: LITEIVB; 1 HGIISnB; tSOSFHOSODS; rOUSSIIR; 1 50DIDB; II1C; BfOtCcmOLaTIOl; I cmncns v«Et 1 a) 113 » or - SO I >) lea, lo» tlood preaace »j blood fresanre og/»l I taafc tcoa vmloes atojj. a«tlaat«d 1 dallr dietary Intake 4.5 a?. 1 t Polynesian icsidenta of Vokelan 1 Iflands, crovded condltloaa. 1 (nceiateiee eooaoar- lea, eaa a«e 1 45 jt, aeaa fct 1C7 ea, aeaa « 74 k« 1 (oaea, a«ao a«e «* rr. aeaa bt 165 1 ca, aeaa vt 79 kg.. 1 1 COPPEB; Zinc; BIOOD SSBOHi BUB; I «IILS: mint - - . t (BEIT P»SB) ....,.,. HfEEEICE 0»ls, B.I. anerys, B.B. ncaet. J-P Bernard. 1. «ei EmTlcoBaeat&l Beaeaceli 24:117-130 Gotbcie. S.B. Coblnsoa, B.T. 1178 leu Zealand ledical Joacaal $7 (603): 3-8 llereabaaa, a. L. Tlelscaaaa, I.I Dmn, 3. Inoli, J. 1975 lancet 1(HU): 1008-1016 RcKemie, J.B. GBtkCl. I. I. Prior, I.a.B. 1978 iaericaa Joernal of Clialeal latrltioa 31:422-42) o v£> ------- time atw «$,}•. tt »19.5 c. BP »0 C. TP 1 n Bg at MT C. 10 n B< at 5?0 t t c iissn iifosm MR> ISCT 90M ••RO* 1 I 1 5<« Braia 1 1 1 1 1 I t »s«« 1 Brail 1 f 1 »570 Brcat I 1 Julia lit Ion iniYTXCal IKMOB US n t ili PUB mm or cisss «l t W s i luei i mi* i ezirui nrosuTitw i nrimci 1 1 1 II I a) lot glT« \| ) 10.« «g/o w»t rt f •) ork«r I By»do. K. b) 1.9-12.5 nj/» nt «t 1 b\| lot gi»«« \| t) coitcol* 1 Saioki, 3. 1 1 1 tmcmjt, I. 1 1 Japa»M worker, 65 yr old at 1 Bcshlzate* K. 1 1 ciroiat* crad«cl»9 »la«t fat 30 ir. 1 1«0 1 1 Bled of aailUarr a»d la caacer. \| Zctenatloaal archive* 1 \| cettrol, 59-7i ft oia. 1 of Occip«tiOMl tnl 1 1 1 «BTitO»»«»t«l HMlth 1 1 JJtM; HIIPOS1 TI3SUI; lOXTt; SOfB I «:!«!- ISO f \| nlCO; (1111} CREIKIM; CMEI808; \| 1 1 IIDUtS: 1ITSB; MISS; BOSCtIS; I 1 i tncsm; sue cKonoi; CCCPEH i 1 t tiriii: tile: inosTim. PURS: i 1 1 IlllUTICt; COCITPtTIOlU, BltllKS: 1 1 i tcFiunoi txrosns i i < i 1 I l •) 8.4-1T tg/g (Mt «t) \|i) 11 » or - 3.0 ng/g 1 •) Balm. c«»bt«a, t mbjcets 1 Tifca», a. b) T,-9.2 »V9 (ot «t) 1 (»«t «tl 1 t) r«iali«. content, 3 «b}«ct« I sazaU-TMUoto, s. c) 9.7-17 tq/f (nt it) \| b) ». « « or - 0.9 I c) B«l«, c«r«bell«», C mbl«cti 1 liuo, 1. 9) 7.8-22 wi/g (mt it] \| 19/9 (mt irtl 1 d) M»l«i. CKclMllm. • <b-j«cti 1 T«»l< R. 1 c) 13 « or - 2.S og/tutloi>« Japac. I Eavlroncmtal B«alth 1 («t "t( \| lalva. ma« »ij« •». 6 rr. F.MlM, I 35(1>:J«-»« 1 j ia> aa« 37. t fc. \| 1 1 1 1 i Tucr nsiEiis; tirotsissi JIPII; i 1 i naarna: nsaics CIBBIOB; COBUT; i 1 i ciicBiui: CCPP!§: HOI: iMcmt: i l i nrioB: Bieftsni: a««s»«tsz; i 1 i i»»ioii7«.- i»ii»o»r,- scjnign; i l i auBiius: iiunn; UUDIHIS UK: i 1 1 S01D; BIOBIBI: LITE1: KIDtnS: 1 I i ctKssm; criiBiiiffa: RIII; IBSCIJS; i 1 \| EtICBIU; SPIKI; tOWJS; 1OBIH: I 1 1 BIHISi COBMSITITI STIWITICBS: SIX; \| 1 1 FCItrSXC BtOICIBB ( II 1 a) dot glm I a) It. ag/g \| a\| tor tec - nnbcoa (occipital) f Syoio. (. b\| 11.0-12.* aj/« \| 1\| lot »ir«» \| I) S caitroli - cerebral (frontal) I Small, S. c) lot aiT» \| e) 13.5 aj/f I e) lorker - cerebellM 1 Foray, I. d) lot giTB I i) U.O ag/g \| d) 1 coatrol - c«c«b«llaa I Mialzaka, K. 1 r«t «t ( \| 1910 t 1 Jipan««« «ork«r, 65 rr old, at 1 latenttloatl trchlTM 1 1 cbroaat trodaclat pltat for 30 rr. 1 of occupational and ( 1 tl«d of nzlHarr ni luv cucor. > CaTlroueatal Hvaltk 1 I cc.tcola, 5»-7» jr old. t M: Id-ISO 1 1 1 1 1 JIP1B; ID IPO SB TISSOZi 1OST1; BOO 1 t 1 eUBOl; BBlIi; cnCBEUIIHi CmEEtVI: 1 I i KIIIETS: lira: HISS: aasciis: i 1 i dictns: sun; cnonoi; caifti; I 1 1 »R1U: tltC; IMOSnlU. PtIBtS: 1 1 I 1I»»UTIO»; COCVPITIOIIL BIH1BS; I l i termiTioB EIPOSOBE i i i i 1 1 1 ot gi»« \| «.» ng \|(1 s«ipl«d at rat of 1 1/aia, 2-10 f UselBson. E.e. 1 1 all aft«c baral«« * arc »«lalag rods. I 9«ndel««r, 6.5. 1 1 1 Johausog, T.B. 1 1 Oal»erattj phfiics shop, Florida I Vlocbeater, J. «. 1 1 1 H7t 1 1 FIOHDU UBITS; BRUTE; CaLCIOH; I linal of Occupatlonsl 1 1 ctLOBiit; CBXORIDB; copisi: uoi; I iTgleac 19:225-238 I I mo: alienist; ncicst: MTISSIUB: i 1 1 SOIFOJ: TXT1IIVR: TM1JIDS: XI1C; aXC 1 1 1 polnnioi; mats: iiraasTBiii. \ i \ IYBOSMBICS; nkct xurans i i i i twit M6») U) M O ------- Hue 7«0-CC-« atl .5.38, BF «1».S C. BP 908 C, » 1 u 89 it M7 C, 10 n Sg at SSO sissm «71 Utr »M2 la.il M73 Bic »S1» lt.tr ifosan soon Itqtttlot iHiTTicit a MOD 11* IS* US mm or cms 31 22 t 2 HMg i Mot «!•• 1 Rot flm 12t.«-201.« 04/9 a) lot fiMD b) lot «lT«B CJ lot 9i»«l A) lot »lw« mi i cEiziiL iiroiBaTioi t 1 1 ) 139 ft \| •) l«»c»lng «la«bl«d ) 1»0 ppa \| t) contrail 1 1 Iticnlnf dlsiblad »id >oc»l 3rl and 1	1« «o «U, on aiml»«ion b) l«2 «o/g \| t> n 19 old. n aliiailog c) 13S «9/g I c> 10 M 014, r«cornd 4) 258 «9/9 \| a> 11 10 old. c«oT«r«d 1 Ccppoe-a«(iel«it chlllni. • 1 C1S« ETST01IIS; CIILmili 1I3Z»XS; I tut: cofpti; anus: me «l«l USE) ' ' - KBTEKEICE rial, X.O. PatkM, I. 1WI Sclaace 198I»313):JO»-206 Ctlttlvborowih. 6. 1980 Seine* of the Total f»lro«M«t U: 53-75 Chlttl«l»rot>9b, a. StMl. B.J. 1980 Sclottco of th« total tDTlroBKOt 15:25-35 BcaatloU. S.E. Cotluo, 1. B«ttl, 1. Graba», S.G. 180 La»Mt 2(»190) :l«3-ail LO ------- line 7100-66-6 n t« 65.38, HP 419.5 C, BP 908 C, vp i aa Bg at 487 c, 10 aa Bg at 590 (CORTIROED) TISSUE 4575 Balr 4576 Ralr 4577 Balr 4578 Ralr BTPOSOBB BODTB Inojestion lUlTTICU HETBOD HI HI IIS HOSBSB OF CISBS a) 16 b) 22 c) 13 d) 11 el 15 f) 22 g) 10 h) 18 i) 13 1) 3 kl 7 1) 12 . a) 23 b) 19 O 42 e) 26 O 40 a) 17 b) 17 O 30 d) 30 BIRGB a) Hot given b) Hot given c) Hot given d) Hot given e) Hot given f) Hot given 2) Hot given ) Hot given i) Hot given fl Hot given k) Rot given 1) Rot given a) 108-190 og/g b) 120-357 ug/g c) 108-357 ag/g d) 103-194 ag/g e) 139-318 ag/g f) 103-318 ag/g a) Hot given b) Hot givei c] Hot given d) Hot given BEIB a) 218 or - 9 ag/g b) 225 or - 9 ag/g e) 200 or - 32 ag/g d) 225 or - 16 ag/g e) 232 or - 22 ag/g f) 225 »r - 296 ag/g gl 105 or - 37 ag/g h) 245 or - 52 ag/g i) 140 or - 49 ag/g 1) 260 or - 87 ag/g k) 180 or - 41 ag/g 11 175 or - 118 ag/g a) 150 ag/g b) 167 ag/g d 161 ag/g 4) 145 ag/g e) 168 ag/g ft 166 ag/g ledians a) 216.2 « or - 43.2 ag/g b) 239.7 * or - 108.5 ag/g O 181.6 » or - 31.4 ug/g d) 235.2 » or - 47.2 nqSa Mysy G8IIB.U I1?OBHATIOB a) Controls, at birth, aales b) Controls, -at birth, females c) Fall-ten low birthvelght, at tilth, aales d) Fall-ten low blrthveight, at tirth, feiales «\| Pre-tern, at birth, nales f) Pro-term, at birth, females g) Controls. 3 BO, Bales h) Controls, 3 BO, females i) Fall-tern low birthvelght, 3 aa. tales 1) Fall-ten low birthveight, 3 ao. females k) Pre-term, 3 ao. Bales 1) Pre-term, 3 ao,. females lUdians » or - SB Reonates in Balifax. Pro-ten group mean birthvelght I860 g, 26-36 »k gestation, fall-term low birthveight group mean birth weight 2371 g, 38-42 «» gestation, and full-tern controls mean birthveight 3590 g, 38-42 vk gestation. aaiB; amis; ZIBC: COE;EB; BIRGME3B; VMaDIDB; IODISE; IHPaHTS; SIX 0) Rale controls t) Peaale controls c) 111 centrals d) Dale tnltiple sclerosis patients e) Teaale multiple sclerosis patients <> 111 an It 1 fie sclerosis patients Samples from 7 scalp sites in each sab ject CHID; igaits: CKBTHIL HEBVODS STSTEB DISUSES; HUB; alOHHTOB; BBonuB; catena; CHLOBIBB; COPPEB: 8CID; IODISE; BIBOaRZSB; RBTalS; SHE", Til: SI17EB; SODIOS; S01FOS; VI»»DHJB: lire levle. Profile of healthy subjects. Baseline data foe determining changes in nutritional status from industrial (aod processing techniques. RIB tBIlIRO; IDOLTS; FBTOS; IR1BTS; BIOOD SEB0I: HUB; KIDIBTS: IITBB: RIIK; BSVIEl; DIRS; FOODS; SOIIS; ?tORITIOR: CtDBIDBl; COPPBB; BIHGaBBSB; RR11S; TBICB E1EBEBTS; me 01 Bothers of infants with scina tiflda t) Infanta vith spina bit Ida c) Control aethers d) Control infants Hevborn with cystic spina bifida. and Bill): ZIRC; IHFIBTS; PBBGHIHCT: TBICE IIESBBTS: GEBHIHT BBFBBBBCE Gibson, B.S. Dewolfe, B.S. 1980 Bntrition Beports International 21(3):341-349 fiyan, D.B. Bolzbecher, 3. Stoart. D.C. 1978 Clinical Cheaistrv 24(11) : 1996-2000 Gathrie, B.B. Boblnson, R.F. 1978 Rev Zealand aedical Journal 87 (603): 3-8 Bergnann. I.E. Hakoseh, G. Te«s, S.-H. 1980 laerican Journal of clinical Bntrition 33:2145-2.150 ------- Zioc mg-66-f tm »» 65.38. •P «19.S C, »P 908 C. W 1 mm Rg at 87 c. 10 mm Bg at 590 (COIIIHED) 1 TISSUE t 1 t »S79 1 >alr 1 t 1 \ \ 1 1 1 i • 1 1 »5BO 1 Hair 1 1 1 1 1 1 1 1 1 1 1 t I 1 4581 1 Bair 1 1 1 1 1 1 1 1 1 1 1 t 1 t 1 1 1 as 82 t flem.it • 1 1 1 1 1 1 1 t 1 1 1 1 1 " 1 i 1 tnOSVIS BOJTB ngemtlon IMlTTICll 1 IOBBES BEIBOB 1 OP CISBS fl 1 $ 1 a) 11 1 b\| 13 1 c) 17 1 n 28 1 el 14 1 O 1 1 1 1 1 1 1 1 a) 96 1 b) 12 1 1 I 1 1 1 1 1 I I US \| 1 IS t ) 1^ 1 cl 19 1 ) 15 1 1 \| \| 1 1 1 \| 1 1 1 1 1 \| \| •1 I a) 10 1 b\| « \| i i i i i i i i i i i i i i i i i I BIBSB 1 1 1 1 a) «ot given I b) ot given 1 c) mot givem 1 d) lot givem 1 e) mot given 1 f) mot given 1 1 1 1 1 t , \ 1 a) lot given 1 b) lot given 1 1 1 1 1 1 1 1 1 i 1 a) Bot given 1 hi lot given 1 cl lot given 1 dl lot given 1 1 1 \| \| 1 \| \| \| 1 \| \| \| 1 «1 7.0-43 og/g 1 b) 4.9-25 ag/g 1 1 1 1 1 1 1 1 1 1 1 1 t 1 \| 1 1 1 1 SE»I 1 1 1 1 a) 138. « or - I ag/g 1 W 159.1 » or - ) ag/g 1 c] 108.2 t or 1 ag/g 1 4) 164.8 » or - I »g/g 1 e\| 106.1 * or - 1 t\| 121.7 + or - 1 ng/g 1 I 1 at 94.1 » or - 1 ag/g 1 b) 130.7 * or • 1 «g/g 1 1 1 1 1 1 1 1 1 i 1 1 a) 259 » or - i »g/g 1 b\| 241 » or - \|c\| 163 * or - 1 d) 144 » or - 1 1 1 1 1 1 t 1 1 1 1 1 i 1 («t »t) I a) 24 « or - (vet »t\| \| <««t vt) 1 b) 17 « or - 1 (vet wt) 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 (BHT PISE) 1 EiituL intniaTioi 1 i l 64.1 1 a) 6-11 mo old boys 1 b) 6-11 mo old girls 98.7 Id 12-23 mo old boys 1 6) 12-23 mo old girls - 47. 0 t e) 24-35 mo eld boys 1 t) 24-35 mo old girls 13.0 \| 1 lav Income ccsta Bicaa 6 eto-4 yc oils 47.7 \| \| IIBC; COST! Elca; CBILtSEl: KPUTS; 50.7 I iraiL UBaS; B»IB: SEX; TfilCE \| EIRBEITS 1 5.3 \| a) aigramt children I t\| Controls Iron otter stmdiea • 8.3 \| a) and b) differed n<0.001 1 1 2-69 BO olds, belo 3rd percentlle In 1 ht. U) ------- tine It Its 65.38. «* »1».5 C, Bp 408 C, VP 1 am Rg at 187 C, 10 aa Sg at 50 1ISSDE ' 4583 manev Kidney 0585 Kidney EIPOSOBE tOOTl ' 1 BILTTICUL BETHOD US Bl . . 113 BORBBB OF C1SE3 a\| 21 b) 3 a) 1 b) 5 suet .. a) not given b) Vat given c) 1759-3278 ppn i) 1682-7000 ppn lah vt ' a) «.1-»6 og/g (vet vt) b) ».«-«« ag/j (vet «t\| a) Sot given b) 31.1-66.6 ag/g vet vt - (BEIT ItElB a) 3653 pp« b) 3920 ppn ol 25 11 ppn « 3551 ppa ish vt a) 39 » or - 29 ug/g (vet vtj b) 33 • or - 20 ug/g (vet vt) al 3. 8 ng/g vet vt b) lot given f»GE) GfltUl IVFOGI1TIOI a) 17 cancer patients t) 58 non-cancer patients c) 10 non-stokers (never saofced) i) S snokere, 1.5 packs/day ««topal«s free hospitals It Sorth and South Carolina. Blacks and Caucasians, (dulls, ages 16-91 yr. Children, ages 4 4ays-6 vr. SITUS; BOHtS; 1ITSB; KIDBSTS; RtVtlS; CHTIDEES: CJDSIOB; ?I»C; l»0; SOBTH CJS01IM: SOOTB CJBOTIS1; intopsiES; Gioiccmotinoi; BICUL STUD IBS; «5B; SHOICUO: tOBSCCOS: SEI; >fQ PltS IS a) (tales t) resales Fros a 4roap of tl a at apsis s. forensic redlcal exaiinations, Japan. Bales. M» age 40. t Tt. Females , •ean a ------- ZlBC 7MO-66-6 tn ItB 65.38, HP (19.5 C, BP 908 C. TP 1 •• Sg at «87 c. 10 •• Rg t 50 (COBTIBIED) 1ISSBE «586 Mdnay a5«7 Kidney •588 Liver »589 linr ztosoBB BOOTE •gestion IBUnlClI. \| BETHOD S US Bl BDSBEB F C1SES 8 9 12 a) 8 b) 7 MICE 1S-»7 «g/g 19-55 ug/g 17-* 2 »g/g t «t a) lot given b) lot given c) 3220-12850 ppn d) 720-5800 pp» lab «t a) 37-180 ug/g (net >t) b) 17-91 «g/g (vet ¥t) •Ell \| 6BMB11 IBPOBfllTIOB \| BFEBEBCB \| 1 t 1 25 ag/g 1 a) Controls 1 Bruno, D. 32.5 ug/g 1 t) "orter group I \| Bordberg, G. 25.0 ug/g I c) locker grew II 1 Bester. P.O. et «t I 1 1980 edians I leeeased refinery »»d sselter I Science of the Total I letters, aqea 55-76 yr. exposed to 1 Kmrlronnent 16:13-35 1 i«»»y ratals 1-3 decades. Use 1 \| tstMea retirenent and death 0-1.5 yr I 1 it qro«p I aid 2-19 rr. gcoop II. 1 I Controls, agts «3-72 jt. wko lived 50 1 j III troa the factor?. S»«d«n. I 1 I I SIEON: ciDitns; KNITS: LITEB: I \| IBBGS; COIPlBlTItB ET11BHIOIS; I \| IBOOSTlIU BTCIBBB: BBlSIIlSBBBt 1 \| IRBODS: 1RIIOIT: 1BSEBIC; 1 1 muraim; CIOBIVB; cismH; CBBOHIOR; t 1 cceiit; coppn; SOLD: IBOB; i \| IIITBIIOB; 1119; aiBGlBBSI; BEBOJBT; I 1 BQITBDBBOB: IBOSPH01DS; BDBIBIOB; \| I sciBEioa; SIICTIOS; SIITIB: 111; i 1 T01GSTM: tIBC: BI11TI H121SOS: I \| IBDBST1I11 PtlBTS: SSEITIBS 1 \| • \| twriev. Profile of healthy subjects. I Gnthrle, B.S. 1 Baseliae data for detersinlig changes 1 lobinson, B.F. I la ntrltioial status troa Industrial I 1971 j teat poisoaing techniques. I Be* Zealand Hedical \| < Journal 87 (603) -.3-8 \| BIB ZE1L1BO: IDOLTS; 'ETtJS; IBF1BTS; I 1 BIOOD SSBOB: Bin: HIBIITS; IITSI; i \| BHK: SBTIIB: DIETS: FOODS: SOUS; I 1 tisn»iio»: cuBina; coppii; i \| B1B61BBSI; BR1I.S; TMCE ElEBEBTS; I I ZI«C 1 \| 1 I 1 a) 5063 ppa \| a) 17 cancer patients 1 Hanser, D.I. b) 120 (pn I b) 58 nan-cancer patients 1 Caloeci. l.T. c> 6068 ppa I c) Two 10-19 yr olds I Basselblad, T. d) 3297 ppn I 4) Three 30-39 jt olds I Vllllaas. B.I. ish «t \| 1 Piakerson, C. \| latopstes free hospitals In Borth and \| 1973 1 South Carolina. Blacks and j Journal of Occnpatiosal I Caucasians. Idults. ages 16-91 yc. 1 Bedicine IS (12): 956-963 I Children, ages daya-6 yr. 1 1 1 \| ClTltS; BOBSS; LITEB; KIDBITS; 1 \| IIOITS; CBItCBBB: ClDHOBi 2IIC; \| \| HID; BOMB CUOIIB1; SOBTB C1BCLIB1; I \| ItrtOKtES: BI01CCHB011TIOB; S1CIU. 1 \| SIOEIES; 1GB; SBOKXBG; TOB1CCOS; SEX; 1 \| HOPllSIS \| 1 - I., I 1 a) 97 » or - 59 og/g I a) Bales < Tulcana, fl. (let «t) I t) Fenales 1 Suxnki-Iasnnoto. fl. b) 50 » or - 20 ug/g \| 1 Inano. K. («et »t) \| fret a group of 61 autopsies. 1 Teral. B. 1 forensic sedieal ezaslaatioai. Japan. 1 1980 \| Bales, aeaa age aO. 6 yr. Peaales. I IrchiTes of j scan age 37. a yr. t Ealroneental Health t \| 3S(l):36-«a \| ItlCI SLI8I11S; lOTOPSIKS: J1PIB; ( 1 noaiBn-i; itsEBic: CIDBIHB: COBIIT; I 1 CBBOBina: CCEP^B: IWB: BtBCORr: \| \| IIDHl; RICBISIOB: B1BG1BZSE; 1 1 BOBIDIUI; 1BIIBOBT; SC1BOIVB; I 1 StlEBIIB; TIIIBIOH: flBlDIVB: tIBC: I \| GOLD: BBOBIEE; UTEB: KIDBIIS: I i ciimoB; csBEBEiinn: BEIBI; BUSCLES; i i iiiciEts: sptEEB; mas: IOBTI; I \| BITltS: COilPlUTITB 1T11O1TIOBS; SEI; ( \| ICtllSIC BZIICIBB \| 1 1 u> (BZIT ------- tl«e i«ao-«6-6 t« It CS.3. BP »19.S C, BP 908 C, n 1 n «9 at 487 C. 10 n 89 at S90 (COBtlEBID) 1 t 1 1 1I3SDI as»o liver «S91 HTer 1 »s»2 lint 1 t •53 Llm<\| 1 1 1 r inosm Boats leoeatioo 1 1 1 mimcu BBTBOD us us 1 i i i n B9BBH or c»s «) 1 b) 5 •) 8 M » c) It •1 3 W 2 B1BSE ) lot 9lT«» b) (2.0-107 og/9 mt • a) 30-99 a«yg b) 22-103 «a/» 0) 19-15 ««/9 Wt «t t) ».3-12 B9/9 («et »t) b) 10-t6 eg/o (vet >t) m« i "eiaiiu nrosBuioB I EsreBEBcs i : i i at 123 «9/» Mt «t \| •) torter 1 Brodo, E. b) lot firm 1 t) Coatrola 1 SateU, 5. I I furor* . . 1 Jaraaese iiocler, 65 TT alt. it 1 Reaklzaka. E. 1 cbronte rrodaclao. plait for 34 rr. I 19(0 \| ti«4 of uxillacr u< luv cue«r. 1 tit«r«tioul lrchiT« \| ceittol. S9-7C rr ol4. f of Oce«pttioiial ti 1 \| EnlroiMittl B««lth 1 J1FH: IDIPOSB Tijsnt: IOITI: ton I <6:i«i-iso 1 8IEIOI: BBUI: CIUBXUOI; CEBEEEffE; 1 1 VIDIEYS; LITEB: VIKSl RVSCIZS; f I HICBE13: SKII: CEBOUIM; COPPBI: \| \| «!IU3: tlKs IIDBSTSIIL PltRS; ( I IIB1UTIOI; CCCDPITIOIU. B1Z1BBS; \| 1 ECrntTIOB tlfOSOB! \| 1 1 1 1 a) (1.0 tj/9 1 a) Ceatrol* I Vrna, D. b> ?.o 09/9 I t) Voclnc qroap I I «or4br?;. C. c) 66.5 ag/9 1 «) «ort«c qraap it 1 »e»t»r, P.O. let «t 1 1 1»80 Icdiau 1 t«Ms«4 cf inerr asi «a«ltar I Sclme of the Total 1 tartars, a9«« 5S-7S rr, axpaovd to 1 Bnriroamit 16:13-35 1 k«ar a«tali 1-3 4« limd $0 f 1 k fcoi tke faetorr. S»«a«n. 1 1 1 1 sitcM: ciDitEis; rnmrs; IITEB; i 1 miss: cogeuain irnajriois.- i I UEOSTRIil KtSXZIZ: 8U5VEiaZIT \| \| IRBOOS: tBTIIOBT: IRSSHC; \| 1 TitLinm; ciEmioi; cisitra; cHsoaion,- i 1 ccriti: coppu: eoic: itots I I Liimmrs: tun: DIISJIESB; BESCOBT; i I BCLrBOESUd; fBOSPBOBBS: DOBIEIUS; I 1 sciBDini; stunos: 511 TIB; m; 1 I m«5STB»; UK: Stiffs SlZlSfS; \| \| IIOOSTtllt Pt»»TS: SR1TISS 1 1 1 i 1 1 f«»l«». Profile of k«alttr «biects. I Gatfcrla, B.I. I fascllM data for J«t«riinlBo ekame* 1 Robinson, n.r. r la aatrltloaal «t»to» froi imlattrial I 1978 I feed pol«oata« t«chni7o«». I >•> Zaalaid aedical \| \| Joaraal 87(603) :3-8 \| Mt ZEU1EC: iOOlTS: MTDS; IVrlBTS; \| \| tlOOB SStttHS Hill; IIOKIS; IITIS; \| I iltlt; ttriTS; BIBTS: ?OOSS; SOUS; 1 I fterritioB; CJDBWS: COPPU: i I BIIClIESt; inal5; IB1CE IIZBEITS; 1 1 tllC 1 1 t , 1 1 8.5 » or - 3.8 fa) f!al«s 1 lokava, B. g (vet «t) 1 t) eaal«E 1 Sanki-Taaaaoto, a. 13 < oc - 1.2 ig/g 1 t laaoo, E. t «t) 1 rroa a group of 61 agtopslas, I Terai. B. 1 fervaslc aedical exailaatloi, Japan. 1 1980 1 Bales, «eaa aoe »o. 6 rr. Feiules, t irckivea of 1 ie» » ------- Mac 74«0-««-6 »t« S5.3B, n »1».S C, Sf »0a C, n> 1 •• Hg It «87 C. 10 » Sg at 590 TISS03 »59» laag 595 Ivag •MS lilk tosnt tons lagaatioa intTTIOL BsraoD us us 1 1 I IBim \| B1KB OF C15IS \| 1 I 1 a) lot givea 1 b\| 10.0-13.7 ag/g 1 e) lot glvea 1 d) 12.0-19.1 ag/g 1 a) lot given 1 « 7.5-1J.1 ag/g 1 »et vt \| I 1 1 1 1 1 1 1 I 1 ) 1 1 a) 8 la) «.»-2» og/4 b) 9 \| b) 6.2-16 ag/g cl 11 1C) a..?-* 15.3 ag/g 1 Wet vt \| 1 1 1 1 1 t 1 1 1 1 1 1 t \| 1 1 1 1 1 \| 1 1 1 1 1 1 1 1 1 I Kilt \| 6BI1UL XIFOIBmOl 1 1 ) 8.5 ag/g \| a) lorkar, right apper lobe lot given \| 6) S eoatrola, right upper loba 13.3 ag/g \| c) Vockac, right aidtle loba i Hot given 1 d) 5 coat roll, right aiddl* lob* ) 12.8 ng/g \| •) (orker, left lover loba I lot given I f) 5 coatrols, left lover lobe at vt \| I Japaaaaa varkec. 65 Tt old. at 1 chroiat* crodveiag plait for 30 yr. I Clad of aaxillary aa& laag cancer. 1 ccatrols, 59-7* yr old. 1 \| J»ll; aDIPOSS TISSUE; 1OET1; BOIE \| RIMO«; IB1II; crBEBEHOB; CIBIEBOB: 1 IIDRIS: lltM; IVIES; BISCLIS: I f»Ct. Snzaki, S. »roy», 1. 1980 lateraatioaal archivaa of Oceapational aad tBTiroaaaBtal Bealtb act 11-150 Brnne, 0. aordberg. e. Vaster, P.O. 1990 Sciaace of tba Total, BaviroBMat 16:13-35 Gnthrie, B.B. Bobiaaoi, a.r. 197« lev taalaid Radical Journal 871603) :3-8 (HIT PISE) ------- Mae 7MO-««-« fa ttf «S.3». n 4T9.S C. B» 90 C, TF t M la at »»7 C. 10 aa So at 590 (commtD) T1SSVI »S97 Rascle »S»» Bascle t 1 1 4599 lail 1 f f MOO Vail 1 1 1 I xxtosns sown 1 1 1 i 1 1 1 1 1 1 1 1 I 9 1 ' t 1 1 1 1 Zaovstios IULTTIC11 ratios n us 1 1 1 1 1 t f I 1 It 1 1 1 1 » I 1 1 1 1 us •rain or USE «» * b> * 1 1 « 1 1 1 1 - -* ( 1 nl 9 b) 11 b) 17 \| I c) 19 < a is t - Hisi ! •> 10-73 eg/a (vet «t( b) 11-72 ag/g \|et at) nil i GEMUL nroiimei i nmiici l l i i S1 » or - 1» ' ' (»rt wt) \| t) resales I Sn»kiTiraaoto, I. b) »S » or - 25 ag/g 1 \| tnano, I. (rat t) \| froa a groap at 61 aatepdea, I Terai. I. 1 foreaaie neUeal exaniaattoaa, Japan, t 1980 1 Bales, aeaa age O.S yr. resales, I IrckiTes of 1 aean a«s 37.« yr. I Environaantal lenltn 1 1 35(1)53-" l TMCE tanns; tnorsnst jun; i 1 HOBnOT; 1ISEIIC; ClOSIM: COBUT: \| t cncBTKB; comt: itoi; incnr: t 1 iinnB; msusioB; uieiiissj i 1 laiiBint; iniBorr: sciniii: ( l snnxm; Tntiira; nitBim: nic: i 1 COIB; Btoaif!: urn: noiiys: i 1 1 CIII»n«i CntBEUVI; »ltt; BBSO.es; j l l EIICIIIS; sttxas wmss-. iciri; i l l intis; coaritiTin zrutrtTiois; SET; i 1 TCIIISIC BIBICIIE \| . — . 1 1 lot given 66.0 ag/g »et »t 1 \| \|Todo, X. 1 1 Sasaki, S. 1 Japanese eorker, «S yr old. at 1 raraya, 1. 1 ckroaete srodaclnq pltat for 30 yr. 1 ResUzvka, I. 1 tie, of aailllary aad lang cancer. 1 19S9 1 1 tateraatioaal Irchives 1 Jim: IBIFOSB Tissue: IOST; tout 1 of OccaBatloaal and a) lot given b) lot given lot given >) lot giVM •) lot given ) lot given 1 BUBO: mill: cnn»lltr»: cmaoii 1 laTiranaeatal Baaltk l iiDinsi urn; vnest iirscizs: i »:ii-iso 1 tiiciitst sm: CB10M0B: catitt; t 1 BIT US; IIBC: IIDOSTSIU »U«TS; \| \| IHUtTtOI: OCCOmiMlt lltUBS; \| i tctmmo* Hposnir. i i i » 1M » or - 75 pps I a) (oaan \| Jtanabrocki, s.l. W 153 » or - 68 ppa \| t) lea \| Kantbrocfci. J.I. 3ry »» 1 I«rt tkoab \| Greco. J. 1 llso rerievedt knmn levela 30 other 1 ICaplaa. t. t eleaeats \| oester, I.T. f 1 Brar. S.s. 1 taalthy 20-60 yr olds \| e«staf ------- time 7»»0-S6-« It Itf tt.39, IP 419.5 C. BP 908 C, fP 1 M 89 at M7 C, 10 •• !« «t SM tcomim) fXSSBI Patents a«02 Pancreas •603 Piervsx Skin foson tons HUTTICIt BTTBOO IS US us r ctsss 7 3 aj 1 ) 5 a) 1 b) i a) 1 M 5 JMCI 1»-«3 ng/g (Mt etj 32-0 ag/g (vet »tj 1 Bot given 1 2t.1-l.a tg/9 »et vt a) lot gin* B) 15. 7-22.7 »g/g vet vt a) lot given b) 5.1-7.9 sg/g Mt lit Mil \| 6SBISU IBIOIUTIOX I BETBinCI 1 1 1 1 29 » or - 9. S g/g I a) Bales I Tvkava. a. •et «t) \| 1) resales \| Saznki-TMasoto, S. 36 • or - a.o ng/j \| l laaao, x. (vet vt) \| HOB a groan of <1 sntopsies. < Teral. 1. 1 forensic sedical exanlnatiani, Japan. 1 1980 t Isles, senn age »0. 6 yr- 'analog, \| archives of 1 nean age 37. « yr. ( Zsvironsental Bealtli 1 1 35ID-.3S-M 1 TBICB nzBtns; iirroMiEs: Jipti; 1 1 iiiBnm: usnic: CIDBHTB; coBut: i 1 cncBxra; conzt: IBOB; HIBCDBI: i l lining! aiGitsivs; aiieiBtsz; i l PVBIBIDI: ixnaofT; actBDira; i i snnina: tiuBiot; nnoitnj zixcs i l con; BiOBiBZ: irrra; noxtTS; i 1 cmmm: CIXIBZIUIB: BUM; ansais; i 1 IIICBBISI SP1IKB: LOISS; iOITl; \| 1 a tins: coBpiBinn XTUVMICIS; stt; \ 1 1C1ZBSIC BIC1CIII \| 1 1 a) 37.2 ng/g Mt vt la) lorker I HyoSo, x. b) Bot given I b) Controls ( Saioki, s. 1 1 rnrnya, B. 1 JicauM vorkec. 61 vr olo, at 1 Besai«ka, X. 1 caroaate [rodacing plant for 30 yr. I 19BO 1 tied of nezillarr and lung cancer. I International Urcaives ) Centrals, 59-78 vr old. I of Occupational and 1 1 Znviroueatal Health 1 jirjn- IBTJOSI tissai; IOITI-. mm i ««:i»i-iso < BlltOf; BBtll: CnEBtllDB; CZBIBBOB; I 1 KIlBEtS; IITFJ: LOBSSj BBSC1ZS; I I IIBCllU; SXIBi CBKOItBB: COPPXB; I 1 Bints-, tixc: icggstiiii. nms; i 1 IIBIlinOB: CCCOV1TIOBU UZ1IDS; \ 1 POPOUTIOI BIPOSB1E t 1 \| 1 \| a) 22.2 ng/g Mt vt \| i) larter \| Byodo, X. b) lot given \| t) Controls \ Suzuki, S. t 1 Parori, X. 1 Jatanase «otker, S5 yr old. at 1 Resfciiakn, X. 1 catenate cretacing plant for 30 vr. 1 19(0 1 tied of aaiillarr and lug cancer. I Ivtenational Uehives 1 Centrals, 59-78 yr old. 1 of Occapational and t 1 ZBVlronnental Bealtli 1 »IBi IBIMSI tlSSBZ; »OBT»J 10(3 I »6:1«t-15(l 1 BlltOT; BI1IB; CnCBZLlOB: CnXBSDB: I 1 KIDIBTS; Ufa: HISS; BOSCIZS: I I mcit is; SIM; craonsa: cotpii; i l nnus: me; n&nsTBtti nins; i l iiauutait cocnrmoxiL utiios; \ 1 ECPDimO XXPOSOI9 \| 1 1 a) 10.1 sg/g Mt «t e ,} lorker I Brado, X. M B»t given \| b) Controls ( snvki, s. 1 1 mrayt. 1. 1 Jatanese worker. CS vr old, at I Beshiznka, X. 1 tfttonat* rrodnclxg plant for 30 yr. I 1980 1 I ltd of sutllaET »& l«ag cancer. t International archives 1 Centrals, 10-71 yr old. 1 of occupational ua 1 1 Znvlronsental Health 1 31t»; 1DIPOSI TISSUE; IOBT1; BOIZ 1 »«:1<1-1SO 1 BlltOt; BStll; CtBZlZLIN: CnZESDB; I 1 xiEins: n»n; inxes; ivscus; \ t (IKBZlS: SIM: CB10BTOB; COPPIl; I t atTtis: sue: IWDOSIBIIL puns; i ( IiaillllCB; QCCDPKTOBU. BIIlltDS; t 1 fcpouTion txposomz i SO ------- Tlie ta Itl «5.38, H» (19.5 C, B* 908 c, « 1 aa Bg at 4«7 c. 10 en Bg at 50 tissus BXfosBi: TOUTS IIU.TIICU. BZT10D •COS I-ra- apeetroe Spinal cord 1 1 1 1 1 t 1 l t 1 ««o« I n Spleen f ( f f t 1 1 1 1 1 1 ««07 IIS (OllZt \| »iei 1 nil \| 6BI1UL mCIMHOI 1 BZmBBCZ or cisKS lit i 1 1 1 1 ) 1 1 1 a) 7 \|a) 39.6-202.5 og/g I a) 83.8 or - it. 3 \| a) Solar nenron disease patienta 1 Karlander. B.B. b) 12 I b) 3».6-85.9 ag/g 1 ug/g I t) coatrala 1 Sattan. B.I. 1 BIJ t 1 b) 52.2 or - l«.3 \| Tvatral kora tis-ae. aatopsi 1 1979 1 1 og/g I 1 annals of leitologr I \| arr vt \| fatieata died of avotrepklc lateral 1 (1)t31-24 1 1 1 fclerosts aad progressive aasealar 1 1 1 1 atropkr. aean age, 5«. 6 « or - 13. 1 1 1 1 1 It. Control! died of varioas 1 1 1 1 diseases at 60.9 « or - 11.1 vr. 1 11 1 1 l i TIII-; iBoiiss lororsiss; i 1 i t M-KOTseoiai vz-Bi-xs) srnu. coio-. i 1 i i tioicciTioniiof : CJUCIOB: COPFBBI i 1 l l itoi: itic: ureaixsz; anus; i 1 1 l SniBCTI: ZlfC \| i i i t III l a) 9 \| a) C.S-45 120 I Salsiaen, B. 1 1 1 41 50 \| d) 122282 og/9 1 d) '85 or - 10.8 \| a-/g ta IB acil 1 1981 1 1 1 e) 26 \| e) 143-339 ag/g 1 ag/g [ c) Bentine, arbaa area I Ircblves of Oral 1 1 ( f) 26 \| f) 169-538 ag/g \| e) 19 » or - 20.4 \| d) tMael. aa in (a) 1 Blologr 2t:1-6 II II «g/g 1 1 1 If) 301 « or - 42.8 II II ag/g 1 1 1 III 1 III 1 III 1 1 1 1 i f i i i i f i 4C08 Xftgeatian US a) 15 a) lot girca Triae b) 17 b) lot given O 19 c) lot girea d) 15 d) tot givea t l - a) 539 » or - 355 ug/2 br b\| 522 » or - 288 •9/24 kr c\| 343 » or - 222 -g/24 kr 4) 127 * or - 251 ug/24 kr e) Inaael, aa la (b) I i) laanel, aa in (e) I latiaated free grapb (a,b,c) \| lg< depeadeat data al» presented. 1 la accacalated la dentine np to age 1 if 1 1 lesideats of Finland 1 1 niltni 10!; SEX; T.KTB; COBP1BHITE 1 ITlIOlTIOirS: BIOMSW1; Tile; SDMI I JSI1S; K1B» 1BZ15; BBT1IS 1 1 a) Me. lov (load preeeore 1 aer.ea-ie, J.B. t) Ma, klgh feloed pre-nre I eathrie, I.I. c) lonea* lov blood presaare 1 Prior, 7.JI.S. 4) voaea, kigh blood presaara 1 1978 Subjects selected by Uood ptessore 1 taerican Journal of rank fcon previoas stndr. Bstinated I Clinical ntrition dailr iietari intake 4.5 ng. I 31:422-428 1 folvaeslan residents of Tokelaa t Islands, cro«del eoaditions, 1 subsistence econonr. Ben, n«an age 1 1! Tr, aean lit 147 en, nen vt 74 kg. 1 leaen, aeas age at vr, nean kt 165 1 ca, aeaa vt 79 kg. 1 1 CCEflE; IT«C: BIOOO SIBOS; I1IB: 1 tins; Mill; 1Z1 ZEU1E0 I 1 N5 O ------- Stic, Kltr<»?«a 3,7, 12, 17-t«tra»athyl-8, T3-Uiiadiproplo«ata<2-\|\|- (8 CT) l»c. n.12-ai»tlienTl-J.8.13,17-t«tr»»«thyl-21S.23H-porphiBe-2,H-dipropiiioato(2-)-I(2I).«W2),I(23\|,»(2«»)-. C3«-H30-M-0«-In- 21 II 626.03 TISSUI »609 Iloot. call* Eiiosvn IOOTE >B»1IIIC»1 BETVOD WSBHI OF MSB 2«0 iMGS a) lot gl»a» b) lot gtT 3V 33 vk aftai caaoral trrthcoeTtas (atlaatad frea araph Cavaldarabla dlt£«t«moa la rata of ebaiga aaa plataaa stata for Xa Iaa4 saaltai torkars ItntlS; BIOOD; MTTHBOCTTIS; CC9F1B1TITE tTHOlTIOIS; USOSTtlll iicinit mi: xnc OIGHIC ccnposins: iieosmsti itiasraEits; IIBIUTIOI; CCCBPlTHWil BiJWDS; SRIITZIS SSfEBXICE Baslay, E.I. llabisk, S.B. 1991 Journal of fba taerican Inanstrlal Byqiena lsociation »2:«2-«6 rlcconlgi 7»»0-67-7 It Id 91.22. IIP 1852 C. BP 35T7 C TISSDC Bale IIPOSOBE son: t lutmcit BETBOD IOBBSB \| or CISES 11I6E 1 1Et( fillllll I«roBB»TIO« Vavia»« 2V caprasaata,tiTa pra-aalT»la tr«ataants ara tatnlataa. Iba faacibllity of a bcllatle. no-«a»h policy for hale laalysls 1* outliaaa «ad supported. f If III; TB1CI I1HEITS: Bill; IDSTBllH; >IlSOIZR»t IZIBODS; »11LS; PBOTHIS: COMIUTITI IViLV&lIOVS; 1L0BIVQIC; 1I1TBOIT; »siuc: Slim; BKonil: CICFIIDS: ciicnn; CKOBIIZ: CBBOIIOB: coiui: CCPPEB; Sllliai; GE1H1IIOH; £010; login; iBon; tiRBma: nit; MGIEStVl; BlIGUKI; BIBCUBI; tatmimn; HCKBL; CBOSPBCBOS; fQlaSSIHH; SDBIDIUB; SEIEVIQB: siiicoi; suns; SODIIB; SIBCSTMH-. soiroB; in; Tinnm; tuiesni: II1C; ZI1CCII1IB BEFEIEICE Chittlaboroogh, G. Sctaac* of the Total tITlXOMItt 15 53-75 N) ------- 1-eataaol. J-*»rt- C«-B1«-0 II 102.17. If -tS C, SI 1»8.9 C. TP 9.9 •• tl it » C tissue »S11 Bre«t» EIKISVB BOBR IBIIITICIL HCTBO9 8C-HS BOMS or cisss 5* (387 saaples) 11(61 Vat 9lTea 8MB 1 C1BZB11 IVFOIUTIOI 1 1 t 1.12 B«/l ( Beanred at 25 C aad 760 II Bo Ceoaetric \| »S.S* ooearmee 1 ze»«r aa& apper osw-sigaa Jiaita 1 C.370 aad 3.3» aoyl I BMlthr. i-3S rr old. B«an>)ri«9, 1 «rtia black »»4 caocasia ni. 1 cficaqo, 11. BtqWlT co«troll«l 1 «ip«rlmttl co«ditia». 1 III1TB; IICOEOIS; II1IIOIS; tDHUS; 1 ciiatinrtt mtocntoiss TOIJTHI l ciemc coircojDS: mm HUIBDS; i IHIUTIOI; mimisa; uiiaoims; 1 FCFBiirro* nposni; JBBI» IBIIS tETEIIICI Kcota«ia i » at ixs c Tissm ««12 Breath 1 1 I 1 1 1 1 1 siresms aonz 1 1 ,' 1 1 l 1 l 1 i iBunicii HXTBOD OC-9S •0SBSB or cisss W (387 saaples) 1 * 1 1 1 1 BiBei Bot give* 1 1 1 1 ms»» 12.3 ag/1 Geoaetrie 6BBIBU IlrOtUTIOB Caaanred at 25 c aad 760 aa Bg ?.»* oecarrenc« lower aid afpec one-stga« Halts 3.3 11 <5 1.8 aq/1 Bealtkr, 18-35 ji old, nonsaokin-g. Qttaa blacks aad caaeaatana. Ckicafa, II. Blaldlr conttoUed •xpcriveatal coaditlons* HUTt; IICCBOLS; IILIIOIS; IDI1TS; CBLOBIMItg JIBSOCJBBOIS; TO II TIL! CIGIHC COStCJKDS; BE1ITH BIZHftS; IIB11ITIOI; BtTtBOLISS; BB11BOLITZS: KJTOUTIOI taosnsi UIBJI 11:15 UrBBKBCE Krotosxiulci, B.K. Brnaeaa, Q. B. O'Seill, g.j. 1»79 Journal of Inalitical loitcoloqr 3:225-23* to 10 ro 1>Bat«a* 10»-»8-» C«-»8 B* 5«. 12, IP -185.35 C, BP -6.3 C, »P 380 aa B« at 21 C I 1ISS» 1 1 •613 Breath tirosvtt tons 1 IBlimOL I ireraoo OC/HS BUBBH OF C1SES 8 81HSJ Bot detectcd-510.0 og/hr RE1I 78.8 ng/hr GM1S11 HfOHlTIOI Ccapond relates to iroraal tetabolisi. Ho other detaili giTen Cirogeaic sampling teckalgne. I«altbT lilltair and clvillail eiployeea, o.s. ilr Force school of Mtospac 9«dlciM, aqea 23-7 ji. 3 stokers. tllZMXS; CaiOBIBaTlD HTDBOCHEBOIS : CElOBtH! OBGltTC COBTODIBS; cEioioBHiiiiis: naoaiK cosiovins; IS! KB: ILCOtOLS: THUS; AUDITS KFIBZBCI Coakle, J.F. Caap, B.J. Reich, B.E. 1975 archives of EnTiroeaeotal Health 30 mt 290-295 ------- I07-00-S C«-B6 If 5», HP -130 C, BP 8.J C. TP 100 M Hg it -«. C TISSBS «1» Breatt 8IPOSBSB Bom tlltTTICJL BET HOD . ec/ss IHIBIR or cisis s MIS: lot detect«d-3.* ng/hr 1E1I 0.« ng/br critiit nroiiuioi coapomd froa ukaon orlgla. la ctfctc to tails given Crroq«iic KipllD? technique. KalthT illttarT ail elrillai •?ploTB«5, g.s. lie farce School of leroapac* n«dici»», ag«s 23-47 jt. 3 tiokccs. ItlZElIS; CBIOTI1»TZD 8TDBOC1SBOIS ; CE10BHB OIG1HIC COHPOnOS; C8IOBOBHIIJIS: nOOIIK COSPOB1DS; EI1IIB: 11COEOLS; THIS; 1D01TS SZ/E1EICB Conkle, J.p. Caapr B.J* Belch, B.t. 1975 IrchiTes of EBTicountal Besltk 30<2>s290-2W 1-lexuetbiol 111-31-1 B« 119.2, HP -B1 C, B? 151 C TISSBB •«15 Breath EIMSTJES MUTE iiiimcii nilflOD ec-Bs •BBBSt or cisss 5« (387 ncpLes) B1BGB lot given Kill \| 1 2.2 ng/1 seoaetrie 1 email nroaauioB B«aaaced at 25 C ami 760 >a Bg 15. a occamace Lc»«T and apper aa«-sigaa Halts 1.0 •id .« q/l BcaltkT, IB- 35 it old, aonsaolcliKi, gctaa blac\s tad cavcaaiaas. Cblcaqo, 11. Blgldlr coatiolled •ipcrlaeatal coadltloas. tlBlTB; tlCCBOLS; ItUIOIS; ID01TS; tFLCSIlHID ITDBOClBBOBS; TO11TH.I CSSIIIC COBPCOTDS; BI11TK BaZttDS: 1IB1UTICI; UTIEOIISB; BII1EO1IMS: IC?m.»TI01 IIPOSOSE; BBB1B IBI1S similes Kcotosilnskl, B.K. Bcaneaa, G.a. O'Beill, B.J. 1579 Joacaal ot knaljtical Toilcologj 3:225-23* N3 U) 10»-7«-7 «-S1l-0 BB 130.22. B! 18-1(S C 1ISSUB 16 1« Br«ath KIPOSOK FOOT! ivaimcu. BBinOD SC-BS 10BB55 \| OT CISIS 5» \|387 aaapteO BUCK ot Bq 17.6* occurr«nc« Lo««r aad upper oae-slgaa Halts 1.3S aid 11.9 iig/1 B«alt«T, 18-35 TC old, aonsaokinq. ntlao blacks aid eaaeailaai. Chicago, II. Ugldlr conttolled iipaclxntal coadltloms. EBfHB: ItCCBOlS; IlLIJOIS: JDItTS: CBlOIinttD BTDBOCilBCUS: (OUTH! cieinc coBTcmiis: BBI.TH HIT»BDS; IIB4I1TICI; KRItOlIS!!: aZIUOUTZS: tOPOHTIOB BUOSOBB; 1BB1I IHaS tmiEBci rrotosznskl, B.K. Brnneao, G.a. O'»«lll, B.J. 1979 Journal of Inalrtlcal Toilcologi 3:225-23 ------- 1-0ct«w. 2-Mtkyl- t»-B18 n 12S.27 tlSSTJB •617 3raatk smsoBS Bonn imiricii. BITBOD OC-«S itmm or CISTS 54 (317 saaplcsl BIIGI •Ot ppw OM-S19M lilitl 0.83 lid 5.3 q/l !««ltbi, 1835 Tr old, nonnakint. ait« blicki nd eae»in<. Cbiciqo, 11. Btijldlr controll«a ------- 1-Peataaol, 2,2,a-trUflthTl- 1S3-O- C8-B18-0 II 130 TISSUE »620 Breath " IIPOSOBS BOVTI IHLTIICit mama GC-HS IOSBEB or CUES 5» (387 saaples) XilSE lot givea ftKll 1.2 nj/1 Seoaetric GEIHaL XnOSRaTIOl ecasored at K c ana 760 •> Eg »7.«1 occurrence lover and offer one-Si gia liaitc 2.2 aid 7.9 »q/l Bealtty, It- IS yr oil, Boaiaokiaq. atlM blacks and eatcasiaas. Chicago. 11. BiaLdlr ontrolled ciptci natal coodltina. E8IHI: 11CCBOLS; IlLIIOIS; IDH1IS; CaiOIIltTZD BIOBOClBBOtS: TOUTILE CISXIC CC9ECOIDS: ailllH mZHDS; HBlUTIOl; BETIBOLIS9: HIT1EOLITES; 1 fcsonttoi inosoai; IEBH u»s 1 ; EtnmcE Krotoszjasklf B.K. Brwean, 6.1. O'Mill. a.J. 1979 Jotirnal ot analytical Toilcologi 3:225-23* 1-P»ntene 109-67-1 C5-H10 »» 70.13, 8P r12» C, BP 30.1 C, TP «00 •• Hg at 12.S C TISSUE 11621 Breath tMOSWE SOME antmcai. BFTHOD GC/HS IOHBSB OF C13SS 8 sues lot detected-ISO. 0 ng/hr an* 3».1 ag/hr sEtraiz. i«rosaiTica i Coapoud related to aonal ! MtaboUsi. (o other details to 1-Propanol, 2,2-dttethyl-, acetate 926-»1-0 130.18 tissn« ««22 Breath ! IPOS US? BOOTI JlULITIClL maoo ec-«»s IDHBa or cisis 54 (3B7 saiples) BHSI Vot glien H21I \| t.» ng/a •Jeoaetric CtHEll HT01B1I1CJ ecanrel at 25 C »nJ 7«0 mi sq 38.8V occurrence Lcner aal apper one-Siqaa liiits 0.86 and .l na/1 IKalthr, 18-25 rr old, nonsiokiiig. irtaa blacks an 4 cancaslaiia. Chlcaqo. Tl. BigidlT controllea ezperiaeBtal coaditiofta. IBI1TB; HCCBOIS; IllIIOIS; 10DLTS: CElCBimTIO IHIEOClBBa»5; T011TIL5 cisinc coBPcnos: BIIITH HIUJDS; UBitiTici; BZTaroLisa: BEIIKII.IIES; fCFUtlTIOK IIPOSISE; IBBal IBEIS KtttZtCt Krotosrinsfci. 9.K. Brtraeaa, a. a. C'leill, B.J. 1979 Joaroal ol analytical ToilcologT 3:225-234 ------- 1,3-tropaBVdlol. ST-S3- C9-SW-l2-Oa «t 2t«.2S. at 10«-106 C nssvt •623 plant ntromc ions laoaatioi iiumcu. RSTBOD ec mrnSI or cuss i iue> 12.S-7 ag/al nil lot applicable CEIHII nrosiuici 1 aa< « lr aftr SOD a« i> aolntioa. Xaitial nlaa, 12 «-crclobta(cd>)p«BtalM«, 1,1a,2,2.3,3«,«,5.5.5a,Sb.«-4od«c«cWorct«kraro- 335-8S-S C10-C112 SI ««!.«, IP (85 C, TP CIIO(I-C) u ng at SO C 1 iissnt i sxrosmt totrti i intmciL 1 1 \| IRBOO i i 1 i •(» i ec aAipom I 1 1 1 f 1 1 I f I I 1 1 1 1 1 1 t 1 1 1 1 »0»!SS IHGI 1 BK1I 1 CEIIUt IlfOIBlTIOl or cisss i \| i i 1 \| M» •) lot 9i»« 1 a\| 0.172 » or - 0.937 \| •> !«•• 9-1 yt b) lot ji»«» i pp» \| tj >?» 15-M rr c\| lot jir«o \| b) 0.2«3 * or - 0.039 I e) !«•* «5 Tt or > 4) lot «ira \| ppa ) ') Ust Sottt caatral ceatts I •) lot glim \| e\| 0.297 » or - 0.077 \| •) Sotta Itlaatie cams 1 f) lot aim \| ppa ( It Mat Sovtb Caatral cersos I g) lot glna I d) 0.292 t or - o.oig \| q\| caacadaaa h) lot gtT«n \| ppa I b) loa-ca«cab •) T - IlpiJ axtractatla 1 ppa \| lataclal a41«tad. Ml«ate4 iata 1 fl 0.252 » or - 0.03D \| taaaft on alta« Spwlal Study, ri 7«. 1 »Pa \| liaitations cf aaaplc Mlactlon 1 h) O.«06 » or - 0.102 \| ntaotolaw r»atrict iitarpntatton 1 opa \| cC cvaalts. f 1) 0.322 * or - 0.085 1 PPa Simlcal patlut* aid eatarata in all 1 1) 0.2«9 • or - 0.023 eoaatlai >itt «ir«r as* aarloo 10 TCI II II I PP» u, re. ai. n, «s, ic, sc, 71. II II 1 S.I. II t 1 1 OeoMtrlc ««i* lUBJtll; n.01191; GK3BSH; lonisiila: 1 ' II 1 HSSISSirPX; K>»TB C18O.III: SOOTH 1 1 1 1 1 1 1 1 t 1 »625 I tloot. I »bol» 1 t 1 1 1 i SC-BC l 1 I ») 3S b) 12 1 1 i i I CICOtlll; THIS; UIKSt II5S02: I IHSICTICIDBS; Eioicccrsouuoi: rooa 1 CCITMII1TIOI: PBSTICIDBS 1 1 a) lot 4etctd b) lot 4at«cted a) lot d«t«ot«d b) lot dctvcteil - a) toTa Caaal r«aiA«ata r) Tolaateaxi Halt of a«tar«a«Bt, 0.22 to/v Cloaalr aatci3, iia«lt«a«oia control taatlas oera aot prortieiJ for • minis alcaq alta those ttoa tt« 36 lera cual ares rcsiiaats a»apl<4. lactlif eeaaiaqfal control or litcrttare data r«litin to ti» sl?aiflcanca of ta« lo« raaldvaa tctti la ta« field «aple» aialmd. no 4efiiit* coaclaaloas caa ba oravii froa tk« tssolts c«ported. Kaidvats of lav Tork. Controls, aifloToas of ta* SBTiroiMatal Trotectloi IOABCT aid mltorsiti stoieata, lorth Caroliaa. Ill TOBK-. ICRfl C»OU»; B1009; BHSOEMI1T IITBOOS! CBWBIII OJGIIIC CCHOOnS: CBIOJOBIIIIISS; iiiiciLoicBinns: poLTcatosinTro IIIHItLS; TWVL1TIOI IIKPSUBE S»EIECI taiaiaqer. C. •atta, D. sptraeiDO, C. Illliau, S. i»sa IPS 54«/!3-«O-02«, (08 pp. rlatol, 0.1. 180 P1-600/1-80-OJ6, «0 P. u> N> ------- 1.3,«-Betheno-2H-CTClobuta(cd\|pentalan-2-one, H3-SO-0 C10-C110-0 II MO.68. TP OI10CB-71 •• 84 at 25 C ,1a.3,3a, «,5. 5,5«,5»,C-o:ec«cUorooctaaydro- TISSUE 626 Blood, •kola KXFOSmi BOOTI ininicu BKTHOD 9C IOBBJS OF CASES tea UI6I ») .009-11.1 ppn b) .003-. 1 ppl e) .003-0.39 ppa d) .003-0.45 ppn •) .003-0.031 ppa f) -OOS-O.OH ppn g) .003-0.00 ppn h) 0.005-0.0325 ppe mi ») 2.53 ppn b) 4.60 ppn e) 0. 10 pp« 4) 0.06 ppi e) 0.011 pp* f) 0.008 pp» 9) 0.0035 ppi h) 0.011 pp» 6KIIHL IIFOIR1TIOI «) ST ill •i;loT of Lif« Scl«aca Prodocts Co b) »8 nuffacted aiploy*** c) 30 £«iilT MBimrs of aiployets d) 30 employes of llllvd Cheical CcrportioB pnvioislT In Icpona CIO duct ion «) 23 aiplofMs of uearbT bsin«ases () t saraq tnataent plant enployees q) 2 cab OT truck drlnrs k) «0 residents within 1.6 1» of Life Science frodocts Co Besldants of Hop«well, Ti Significant difference In frequency of irnptoaa In kepome vockecs aa ccnpared to area residents: Bashf •ervananess, teesor, Tlsnal difficulties (p<0.001), plvuttic tain and velqnt loss, (p ------- 1.:;,8-DlsetkaBmapktb.aleae, 1,2.3.,10.10-kaxacttoro-f.«>a.5,,a-kexkydro-. eaido.exo- (8 CI) 1.:$.8-DiaetkMoaapktkalene. t,2.$..10,10-kexaCaloro-1,.a.S,8,ea-bexabriro-. (1alpaa,talpka.4abeta.5alpka,8alpaa.tabta)- 3C9-00-2 CI) B» 3«5.tl, RP 10 C, TP «I10(E-«) an Bg «t 25 C «ISSITB IC28 iMlottc fluid «29 Blood «3o ni tt i « I I •631 Placenta »6S2 Placenta EIPOSTOZ son IftOestioa aitiTTicai. i IVBBS> i tun SEtHOD J or CtSSS I 1 1 1 I 9C-K ( 50 1 1-152 ppb 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 I OC-IC 1 t) 25 I 4) lot 4et«ctable-23 ppb I b) IS \| C) 9-80 ppt 1 C) 10 \|e) 18-70 ppb 1 1 1 1 1 1 I 1 1 1 1 1 1 1 1 1 1 1 1 1 ( 1 1 1 1 1 oc 1 a) 21 \| a) tot detected I b) 2« f b) 0-0.00 pp« 1 c\| «5 1 CI 0-0.00 ppa I t) «5 I 1) lot given 1 1 1 1 1 1 t 1 1 1 1 1 1 1 1 1 1 1 ( 1 1 1 1 1 1 1 1 OC-BC \| 50 I 2-1587 ppb 1 1 1 C 1 1 I ( / I 1 1 1 1 1 1 1 1 1 1 I \| 1C- EC \| a) 2S \| a] lot detectable- 15 ppb 1 b) IS \| k) lot Jot ectabl e-110 ppb 1 e\| 10 \| e) lot detectaUe-2* ppb I \| 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 t 1 1 Bill 1 GEIZIlt XimMIIO* 1 IWMEICE 1 1 1 . . _ 1 1 I 20.76 ppb 1 18 posit IT* speclnas 1 Sarena, I.e. Geoaetcie 1 \| Sett, T.P. 1 Pregnant reeea. similar in I Bahajaa, f.L. 1 sccioecoaoaic level aad dietar? \| 1980 1 babits. 10 oceapatioaal or i Intinational Joanal 1 accidental exposare* lacknov, Xodia f of Znvironatttal 1 1 analytical clieilstrr 1 FIST 1C ID IS; CatOHItnO BTCSOC1BBOIS; \| 7:25-751 1 CBICSIJ! OBSJHC COJIPOOIBS; EDI; 3DI; 1 1 IDT; IIDI1; EBESIUCI: IBIIOtlC 1 1 J1DID: PHCIIT1 1 1 1 i r a) 11.1 or - 7.3 I •) Cotrolit fall-ten pre;ia«cle< I Sanaa, I.e. ppb I t) Pre-teri fr»Ua. I 181 1 1 Journal of analytical 1 !•«»: IBOBlioi: 1DOLTS; rnos; I ToxicologT 5:<-* I noci: Piactni: COBPIBITHF i I tmamois: cuotruTta i \| ItrBOCaSSCIS; CB10XII! OROHIC 1 I COCCOIDS; I1SECTICIDIS; PISIICIDES; 1 I rtsnciDi stsiooBS; popuiiiici i I jitosoBS: piteiiicr « 1 1 1 1 a) lot detected I a) Siral icthers, fat basia 1 Pozo lota. t. b) 0.00* pp> \| r) grbaa setters, fat basil 1 Becrera Barteache. 1. c) 0.003 ppa 1 e) 111 aetheia, fat basis I Polo rillac. L.B. d) 0.0000* ppa \| d) 111 aothets, saol« silt basis I loper-Cieenez, 8. 1 Oata for mi of all pesticides aid 1 Jodral Tillarejo, B. 1 ceiparisns sltb rallies of otker 1 Iglesias Perez, J. 1 lavestlgatore aiven \ 1979 1 1 Bevista Espanola d« 1 »n rains aothcrs free Cordoba region, t Pediatrla 1 3Fai> 1 J5(20S):»3-11« 1 1 1 sftj»: tmiTS: si«: CBLOBHI oieinc i I coipooioj; ptsTicnts; IGBICOIIOBE; i 1 ID11L lltIS; DRBlf USaS I 1 1 1 1 158. 7 ppb 1 «« poiitiY* ipeciie«« 1 Saxena, B.C. se«etrle I I Setk, T.B. 1 Ere«naat vonan, aiailar in I Bahalan, P. t. 1 locioecoionlc lerel and dietary 1 180 1 babits lo cecapational oc I Tateraatienal Journal 1 accidestal «rposare. luctmo. InSla 1 of Cnvicouaatal 1 1 analytical Chealstrr 1 CISTXCIDIS: CBLOBIlim BTDWCUBOIS; I 7:25-251 I CBIOBUE 0161IIC COBPOH1DS: toE; DDE: I I ItT. IIDI1: PKB6IIKT; IBIIOIIC 1 1 line; pLjcim i ' 1 1 1 »1 » or - 3.96 ppb \| a) control!, fall-tern pregnancies 1 Sanaa, B.C. 17.9 « or - 2«. 1 1 t) Pre-tern tregnanciajs 1 Siddiqai, B.lt.J. >b I cj spontaneoas abortions at ls tbaa I Setk, T.D* IS. 9 • oc - 7.6 \|8 «k (incudes fetas) I Xrisbna Bnrti, C.I. pb t 1 Bkargaia, a.K. 1 Bealthy, non-exponel, pre^iant aonen. I Rntty. D. 1 age* 18-32 yr, ladla. I 1981 1 1 Journal of analytical 1 lIDIa; aBOITIOl: 1DOLIS; moS: 1 Toxicology 5:6-9 1 nocoi pxtCEnt: coiPiunn I 1 fTllVaTIOIS; CBLOIHUZI 1 1 IHBOCUBOIS; CHIOEIK OXGI1IC \ I cciiomis: iiSECticnis; PESTICIDES-, \ \ tISTICIDt BlSraVBS: VOIBLatlOl 1 11 t 1 IMOSUMt fltetlKT ( 1 1 1 __..... 1 1 OJ M oo ------- 1,«:S,8-DinetbanonapktkalM, 1,2,3,a,10. 10-nerackloro-«,7-«pOT7-1,»,»a.5,6.7,8,8a-octanT4ro-. «uoo,«xo- (SCI) 2.7:3.«-Din«thanoaa?hth(2.3-b)oxir«lie, 3,«,5,6.»,»-b.«iacliloro-1a,2,2a.3,«.«a,7,7a-octabTtro-, (1«alpha,2b«ta,2aalpha.3b«ta.Sb«ta.6aalpha,7bet»,7«alph«)- (9 CI) 60-57-1 I 380.93. BP 176-177 C, TP 7.78X10(1-7) » 89 at 20 C TISSUE •633 Idlpose 63 adipose •«J5 Iniotlc fluid rosns SOOTS lULTTICaL BET HOD GC SC-EC RUBBER or CISES 60 SO UEGE <0. 05- 1.16 ppa 1-3 ppb Bill \| GEIllaL IlfOSHlTIOB \| 1 1 J 1 Exposed persons in the United States, 1 the «ether lands, Sweden, Israel, 1 Japan, OSSB, Poland, Geruany, India, 1 Evlaarin, Pakistan, Austria. 1 1 Beported cases of hypertension. 1 elevated serin ckolesterol. abnornal 1 lies, or iipairnent of neareauscular 1 function after acute exposure to 1 conbinations of pesticides, bat nost 1 datn show no aSnrs* effects after 1 Icnq-tern occupational exposure. \| IDSTBIa? BOXGlBIl: GBRRaEY: X1DI1; \| mm: JlPtl: IETB1JLMDS; PaKISTW; I ICLMD: 1DSSI1: SVE9EI; BIITED I SHIES: tDIPCSE IISSOE; B1OOD: BLOOD \| tUSHa; BIOCO SEME; EITTBEOCTT1S-. \| ItmoCTTES; BI1K; DBIBE; K1TIEB; I BIILTH HIClBtS; OCCOPlTIOlll R1X1BDS; I topniTio* EXPOSORE : IEOPIISRS: 1 CISnCIDIS; CEXOBIIE OBGallC 1 ccRponas 1 t 0.26 ppu I Peripheral kidney fat, routine 1 cntholoaical exaninations 1 1 Iges 6 no-92 yr. Belgian 1 I t»sim: iDTopsiES: IDIPOSS nssas: 1 EIOlCCqilUlITIOI; PESTICIDES; DDD: 1 ICE; DOT; DIILDKII: BBPTICHLOB 1 ItOSIDE; RSXaCnOBOEEEtSlE: URDUS; 1 CrtCIIRS OR61RIC CORP001DS 1 1 2.«2 ppb \| 2 cositie specinens Seonetric I 1 Vreqaant voaea, sinilar in 1 tccioecononie leiel and dietary 1 tab its. 10 occupational or 1 accidental exposure. Locknoi, India I 1 EISTICIDtS; CHLOtnUTID BTDBOC1SBOIS; 1 CCIOSIIS OSGI1TC CORP01KDS; EDO; DDE; 1 CCT; n»It: PtESRllCt; 1B«IO«C 1 IIOID; PlaCtrta lEfEHERCE Deichnann, f.B. RacDoaald, I.E. 1977 Ecotoxlooloay anfl EnTironnental Safety 1:69-110 De^onckheere, V. Steurbaat. I. Tecstraeten, E. Kips, B.I. 1978 Toxieological European Besearch 2 (2): 93-98 saxena, H.C. Seth, T.D. nahajan, i.L. 1980 International Journal of EuTlronnental Inalytlcal Chenistry 7:2«S-2S1 LO ho (HIT ------- 1.«:S,«-VlMtkUMtpktkl«M, t.2,J,«, 10,«»-a««clil 3,»,5.6,9.^-fc«l.ckloio- ta,2.2»,3,8,6«,1,7.-oet«kTteo-. ll««lpi«,Jt>«t«.3«alp»», «0-!T-1 C12-1I-C1S-O «t MO, tj. IF 17«-177 C, T* 7.7««(M> u Of at 39 C a, H>«t.,6..1pli«, 7b»t«,7«.lpi4) - CI\| 1 l_ IISSBI «3« Blood f ««J7 Slwid, cell 1 f t »tos«xs to l»tRXClI, ••MOO » IWBSI or cuss MKX i RUI t EEftut matnnat Kile* trroae4 (wcicta ia tie 9aite4 States tke letaerlago. Snjaa, Iiraal, Jipio, 7SSB. Polaad, saraajf. Itdia, 6«fact«< caa«4 of aYPct«aaiGa« 1 elevated eecaa caoleaterol* abadnal I ties, or lipairaeat of (eareaaaealar 1 faactioa aftec acute aiposuta tp 1 caabtnatioaa af peatlei&ea, tat aost 1 iata aao* ao adverse effect* after 1 lc»«;-tecai occ«p«Uo»al exranre. I lusTBii; BDtsisii: extdiiT: HOTI; I ICIUB: SDSEIl; SIlBtl; MltllD I mns: witcst nsstrsj steccs ttooc I Hijtocrrss; HIE: aiint: ss7iia: 1 E111I3 HH1EIS; DCCUTiTHUU SUlttDS: I FCPOHTIO» IlfOSffBE: HOPtJSBJ; \| ftS^ICI»!S; CBIO«»! OtCllTC ( Kt fOaltS: lIOTllSiS; PISI1CIJBS; I cncem OIGUIC COIPOHBDS i 1 «!av 1 1 tipo»4 p«t»ots la tM anitad states. 1 taa Ketherlaada Svedea* Cacael* 1 Japan. OSS», Poland, Secaanr, India. Eolijarla, Piklstao. Hatrla. B.port.i oaes «f ariwcteB.ic. !!5s. or iapatraeat of aeireanacajar (aaetlag alter aeota etooiua ta ccabittatitfa of peaticid«av bat a0at Jata ako» vt aAvetse effect* aftec leaf-ten occopatioaal «ipoura. icsTBii; aoiemi: GEBUIT; nmi; ICI.1I!>: S5SJ11; SWHEt; UStllD miss-, isiecse IISSUB; sj.coc: noofi ttisnt; iiocc siftw: EiiriEocrns: itmcocnss: IIIK; «»i; atrz»: BIllTJ BIZJBCS: OCCOF11IOUI IIIIKOS: tcenmoi nnson; nonues: IISTICI3IS; CBLOBIII OIE1IIC CCSPOO«3 tzntnci twlckaaaii, I.B. KacsoftaUi ?•£• 1977 Ecototlcolo^T aal rarlruaeatal Safety 1tS9*t 10 Deichaano, I.B. McBoaall, >.t. 1977 3c0tdxlcol&9y aa& eorlraMantaJ Safety 1:89-10 U) OJ o ------- 1.atS,«-OlMta.aBOU.pBtsalam«, 1,2,3.4,19, W-JiMacHoTO-«,7-«po»-jr1».»a.S,«,7,0,8»-octa«f«ro-, ««do,ezo- ft cl) 2.7:a,$-DiMta.aaaaapata(2,3-b\|oxlxeM. 3,aT5,6,9,-besacU.9ro-U,2,2a,3,6.6a,7,7a-octahrara-. it ii i GEituL tnoiuTia* i (znmcs 1 1 1 1 I IfTiav I Deiciaann, ».B. 1 1 a»cDon»U, H.t. I Eipos«a persons la tin OniteS states, ) 19T7 1 tl« Itk«rl»4a, 5r«l«B, leraal, 1 Icotolieolojy and t I>p>( OSSB, Falmsi, (S«rnBT> I»ilia. t CnTlcaueital 5af«ty 1 toiler U, T«U«t>«, lartria. I 1:69-110 4 1 I E«port«d cu«a of kypcrteaaion, 1 I 4l«vat«d •«€«• cbol«kt4coj.c ab4rftl t 1 lisa, or liptlrxit of n«oro»aacnl»r I I (giction aft«c «cnt« •ipo«nre to 1 1 coitiutloia at p«stlcia«9, bat lost 1 1 iitt Stan 10 alT«rs* affects after 1 1 lem-t«n occupational «rposire, f 1 1 I losTRii: BULcuit; eraiui: ni>i>: I i i si in.: Jm»; innmins; luistti; t 1 101 110 ; 1USSII! SnOH; QllttO \ t STUBS! ID t POS1 TISSOS: BT.OOB-. BLOOD I 1 FUSBl: nOOC StElI; SBTTBBOcnBS; I 1 itnocTiis; mit: mm: tmn; t 1 HUTU R11MBS; OCCOPJTIOIU RlZUItS: 1 I ECPtnitioi uposne i i i 1 1 O 0.2 ppb « al Rural tiacla I rtoklm* J. bl 9.2 ppb t t) Qtbaa ll»clts 1 Prtoater. l.i, c) 0.3 ppb j c) Dcbn c*ca«lau 1 Cceason, J,f. d) 0. ppb t i) Kuial ca«eaalanm 1 Ra«Mt, T. \| 1 Kim«. T. 1 ortam an! total rald«ats of sc, 1 laucc, D.t. 1 iifaats, chlKna, .Salts, «M«tlT. t 1972 1 1 li«rica> Journal of 1 SOOTB CKOlIll: AJOITS; CBIIDfiSI: 1 Public Health 1 I1CUI STV91ES: BIOOO PltEBl; 4 6201 = 615-451 1 CCimilTITZ ITllUTIOIS; DOI; PDE; 1 I cti: niBuilii PISTICICJS: i 1 KncHto»rmjo BI?H«IT.S: HI \ \ tCHBTtO»: TOOD COIIUIimoi; 1 1 tisiictot BisiDOES: nmiTion i I tirosn: (ITUL UEIS-. tie it istis t «.) 0.031 p?i 1 l »nt«l «»tbr«, rat baelr 1 Foza Lota, R. b) 0.010 ppa \| t) Dtbaa aothats, tat ba«i« 1 Bercara lartaicha. 1. O 0.020 ppa \| c) 111 a«tb«t>, fat basis I Polo Tillar, I.I. i) 0.0005 ppa 1 SI til aotb«r», (kola silt basis 1 Lopai-Sl»an«i, B. 1 tata lor na of all BMticiBtn aid I Jodcal Tlllar«jo, a. I ccaparivoaa vltb »»l»s of otter I T<)l«$ias Petal, J. 1 iarcstl^atocs qiraa I 1)79 1 1 (arista Xapanola a« I lacciaq aotb«ts fcoa CocJoba realm, t Milattia 1 S^aln 1 3S(2l>6l:J1tO 1 t 1 stm; utritsj friu: CHLOEIIZ OBSIITC i l coepcons; ptsncijis; ISBICTLTTIEJ: i 1 tOBIL U!1S; OBB1» UB15 I 1 1 1 1 UI.2 oc - a.3«.z \| coapated on tat a41asteA basis t savaa, I. P. ppb \| Fauna of a«au for all gaogiaphlc 1 X«efe, 1, i. I c«qlais I tcsaaci, 3.0. 1 1 laealar, B.«. 1 Kcaln? aotfurs, IT. S.I. 1 Ipplebaaji, ».«. I 1 Coos, I.. 1 UIITID STiirs; IOOITS: ans: i rort, 5.1. 1 CCBP»1»IIH ITILVIIIOIS; CBLOBIC \| 1941 1 cremc CD8IOOIDS; DISLDBII; \| laerlcaa Joarnal of 1 ItSIICIDK; laCTmol I Epl4««lolo«r 1 1 1 W3 1«\| i »U-»2J t 1 1 Oin PIS!) ------- t.»:5,8-Di»etliaaoaap«t»alene. 1,2.3,4, 10>10-kexacU.aro-6,7-epoxr-1,B,Ba,S,«>7f8,am-octaavdra-, eodo,exo- fl CI> 2.7:3.6-!)lMthanaaapktb.(2.3-b10xixeBe, 3,,5,6,9. 9-hexaCBlora-1a.2,2a.3,C.ea,7,7a-ectaavara-. (1nalpBa,2beta.2allpha.3beta.Sfceta,6aalpha,7beta.7aalpna)- (9 CIJ C12-B9-C16-0 !1 380.93, IIP 17«-177 C. TV 7.7W10B-7} •• Bg at 20 C (COITC(VED) • Tisstn 4642 •ilk, tat 4643 \| Placenta I 1 t IZPOSBIS BOOT! aflLTTIClL RETBUU OC-BC ' 1 f SC-EC nnsa or cisss 50 SHOE a) lot given b) lot given c) tot given d) Hot gives e) lot given 1-6 ppb nil i ecimi. XBFOBRtnoi I i a) 0.086 or - 0.063 I a) 1972, 40 saaples ppa \| b) 1973. 38 saaples b) 0.99S * or - 0.072 1 c) 1971, 19 sanplas ppa I d) 1975, 20 saaples e) O.OSO * or - 0.040 I •) 197C, 19 saaples ppa I f) 1977, 20 aaaplea t) 0.062 * or - 0.021 1 PPB I 100-141 lactatlng VOKE, 2 aonths e) 0.052 * or - 0.025 1 after delivery- Besidents of Osaka ppn 1 Erefectare, Japan, Taxied diets and 1 ctTironnantal coclitions. t t EISTICIOES; DHIDSII: CBG1IIC 1 CBICBIW! COBPODiaS; Ja»l; UOIIS; 1 tlCTlTIOI: BIIK; BtOlCCDBIIUIOl; 1 EOITCHLOBIB1TED EIPBEITLS 1 3.93 ppb I 2 positive speciBeas seosetric F 1 (xegaaBt «OB«B, linllat in t aocioecoaoaie level and dietary 1 habits. Bo occapatioaal or 1 tcciflental eiposare. Lacknon, InJia 1 1 PIStlCIDZS: CBLOCIIinO E1DBOCIRBOJS; I CEIOBIXB oseinc coapovras; HDD; DDE; 1 DDI; IIBIl: PSICUJCI; 1BBIOIIC 1 IIOID: PllCIITa i SEFEUBCE Takashlji, T. ratanabe, I. Tosnida, S. KnnitaJ «. 19T9 International archives of Occupational and Xnviioaaeatal Health 03:1-15 Saxena, B.C. Sett. T.D. Baha-laa, P.I. 1980 International Journal of inviromental Analytical cheaistry 7s24S-251 I u> NJ 2-B«t«BOl, 3-mottrl- S98-75-* C?-H12-0 If 8S.1S. 128 C 1 TISSUE «CM Breata I 1 1 1 1 EIPOSORS iom 1 1 1 r i i 1H1TTIC11 HRB09 GC-BS g»BR or cists 54 (387 staples) 1 BUGS lot given 9EU 0.378 ng/1 Seoietric GIIIM1 IVFORBITIOI Beaaoxed at 2S C and 760 mm Eg 15. 5f occurrence Io>«c and upper one-Siqna Units 0.123 and t.16 ag/1 Bialtbv, 11-35 TX old, noBSBoklnq, nrtan blacks and cancasians. CaieBgo, II. Pioidly controlled ciperiaeatal coadltioas. f«UT8: iicoiots; HI.IJOIS: IDOITS; CP.LCBIUTZD BTDBOCtlBOIS; TOUTILE CteillC COIFCUIBS; 8I11TB BIHSCS: I'RIUTIOli SSTAEOLISI; BETaBOIITISi tcfouTioii riposai:; IBB lit JEHS misstcs Kcotoszynski, 3. 1C. Brnnean, 6. If. C'Keill, H.J. 1979 Jonrnal of analytical Toxicology 3:225-231 ------- 2-Jataaone 78-»3-3 C4-B8-O If 160.27. BP 74.57 C. TO 71.2 H Iq «t 20 C tlSsOS •««s Breatk 4646 Breath EIPOSOBS BOOTS 1IUTTICIL nrrHOD 8C/BS SC-BS •naiss or cisis 8 54 (387 sasples) Mies lot det«ct«d-60.0 agykr • lot 9ir«n nil 1«.« ag/kr 3.6 ag/1 Geosetric 6ZBZUL iiroBHTioi ccaiomd related to norul ictabollaa. lo other detalla gives Cryoqeaic saapliig teekaiqiM. Dcaltkr a Hilary and clTlliao «iFlOT««s. U.S. Hi Forc« School of Mz«spac« a«Jlciii«. aqes 23-»7 yr. 3 stokers. imnis: CBICIIIKBI BIDBOCIBBOIS; cnoilK oseuic coatonns: CHioBOBiiiiwis: nnoiiis COHJOOMS; IIHTB: HCOBOLS; THIS; 1 DOITS Iiasnrei at 25 C ud 760 •• Si 53.2* occvrrcmce Icier aad spper one-siqaa Halts 1.48 and (.8 aq/1 KcaltkY. 18-35 jt old, aoaiaokinq. actaa blacks aad caacaaiaaa. Cblcaqo. 11. XiqidlT coBtiollcd eipcriMatal conditloaa. »(UB: IICCBOIS! ILIIIOIS; 19QITS; CEICBIBKZB FIDSOC1BBOIS; T011THE ctsanc coBtooios; aztua BIUBDS: HBaUTiev: aniBouss; BIHBOIITES; tcfoiKioB inosm: IBBIB utis SETCBIBCI conkle, J.P. Caip, B.J. Selch, B.E. 197S arckiTas of Znviroaaaatal Health 30 (2) : 290-295 KiotosTTH«kif B.K. Brvneaa* 6. 8. O'Helll, B.J. 1979 Journal o£ inaljtlcal Toiicoloql 3: 225-234 U) 2-Bataaoae. 3,3-diaetkyl- 75-»7-8 C6-B12-0 •I 100.16, » -«».8 C, BP 106 C at 760 aa 18-35 TC old, sonaaoklng. otliB blacks aad caocasiana. Chiciqo, TL. Blgldlr controlled eipcrlseatal coadltloas. HIITI; 11COBOLS; IUIIOIS; JDTJITS; CllOBTIaTtl ETOBOCHBOIS: fOltTILB CS«»TC COIFCOIDS; BB1LTB BaZUDS; iiamTic": lETteoLisH: sziiBotms: EOfOUTIOf IXPOSQIE; H1B1B UBtS BtrEBIBCE \| 1 1 Ktotoszyaski., B.K. Braaean, G.H. O'Helll, H.J. 1979 Journal of analytical Toxicology 3:225-234 ------- IH- &!«-«»-« c»-ie Bf W.12, I? -105.55 C, BP O.S8 C. Tf 1M2 u «t 21 C tlSSIf. ««(t Breath EltOSTOJ BOOJE HlIttlClL BITHOB ec/ss IDWS8 or CASES t 111SE lot dteeted-»0.0 »9/«r Bill 10. S toyhr GIBtlal imrOtBtTIOI Ccifonid relate.1 to mraal •etaooli!. lo other ieti.ll: aitn Crjoaeaic saaplXaa technique. Realthr lllitary «ed eiTlllaa eiploreea, tt.S. Ur force School at lermptc* Betticiae, a«es 21-47 jr. 3 »ok«r. ItltntS; CBIOUHTED mtOCUlCIS; cfltosiiB cieinc cospomiDS: tiKJtosEtztwzs: riaotiix costoatass mattes Coakle, 3.1. Caep, B.J. Velch. B.E. W75 Ireaivea of foTironBCBtal Health 38 (2J 20-295 • 2-Bit«ae. til- 5»0-1»-1 C«-B» II SC.12, IIP -1M.I1 C, EP 3.7 C, TP 1»10 u Bq at 21 C Tissue «• Br«ati 1 ItNSVH BOITB 1 IIUTTICU mtoa ocyss •tJBBIB OT C»S!S a t»ei lot d»tect«d-23.0 «4/hr Bill 4.8 09/hr GUtBll IHOSI1TIOI Cciroiid telat! to Mtul Mttholtsi. lo other details given crroouic nmtl±ag teekaioie. leiltaT •ilitarr and oliilian eeplojees, U.S. lit force School of lerospace iredicia«. «3« Z3->7 rr. 3 stokers* llltniS; CBICEI»«EB BTDSOCtBSOilS: cEioBtiB otetnc conotmst ciiotoiiizivES: renoaiR ccnro0»!>s: t1Z»l; tlCCfiOU; THIS; UDITS tmsttct Comtle, J.I. Ca«p, B.J. leleh. B.I. 197S >CCbiT«> Of Inriioaratal Health 30 (2)! IJO-295 OJ u> 2-Etarl-l-P«>t«eoI C7-BM-0 Bl 114.23, BP 16»-16t C postings IB CBWUTIE). ( TIS5V1 1 1 1 1 treat h 1 I BirOSDJ! IOOTI 1 1 ' "SCToJ" i 1 ac-iis IOBI3B or cisis S» f387 niples) 1I1GE lot ?iT«* 'EH GBIIBI1 IlrOIHTIOB 0. 27i 09/1 Btained at 25 C and 760 la Bif eeoaetric \| 3<.9t occurrence 1 lover ud epper ooe-slga. Halts 1 0.14* tad 9.729 09/1 1 1 lealthT. 18-35 ?r old, nomaoXtnq, 1 vrtan blacka and cavcaaiaia. t Cbicaga. TI. Blgldlr coitrolled 1 tip«riieatl cotlltloti. 1 tlllTT; UCQCOIS: IlLIHOlSi IOOLTS: 1 CflCBISHEB BTDSOC1BE01S; VO11TI1E ( CECaflC COBPCCUDS: BU1TB BltlRCS; 1 IWUlTIOIt BCTaBOLISS: BBIlSOlITSSj I »CPOI»TIO« BlfOSOlB; IJB3H 1BEAS 1 EEfEBEIC! KrotosTTBali. 9.1. Bmneaa, G.R. C'leill, B.J. 1979 Jourul of loalrtical ToilCOloqT 1:225-23 ------- 2-MraiM !»2-»3-s I* 8».16. IP t«1.3S C. BP 68.5 C TISSB! »651 Breath tXfOSOBZ BOOK luinicai 1ET8CO OC/HS •mass or cists 8 MKZ lot detected- 17.0 ug/kc «a» «.0 ag/hr GBIIUL xiroMitiov ccafoatd ranted to aona.1 MUbellM. lo other detail* giwa Cryogenic ailpllao: tackliqo. B«ltkf illltiCT u4 cifillaB (•plains, o.s. itr Torco school of ictaaiwec H«4icU«, «qes 23-»7 yt- 3 stokers. tllZHES; CBtOEIIlTJII HTDXOCUBOMS: CBIOMIB OI61IIC C08PODIBS; cmcionitziis; rtnoBUE COBPOIIDS: II1HI; ItCCBOtS; TSIU: UDITS - taisact Conlcle, J.P. Ca«p, B.J. Belck, B.t. 1975 IrchiT* of IiTicoBMital Health 30 \|2) : 290-295 2-Octaool C8-B1S-0 BI 139.2, "P -31.6 C, BP 178.5 C, TP 1 •• Kg at 32.8 C I 5ISS1! 1 «C52 Breath •«53 Breath IlfOSOM BOWS inimciL "r™o» «/BS SC-BS BWBHI or CISES 8 S» (387 staples) B1«GJ lot detected-98.t uq/tr lot given mi 12.3 ug/hc O.M ng/1 Geoeetric etnui nreiunoi Ccifoigi related to Docaal netabolise. lo other details given Cryogenic stapling technique. Maltiy ailltary aad ciTllian eaployeea, B.s. »lr force School of lerospaee Bedlcine, ages 23-47 yr. 3 IIHEISS; CBlOBlniTBD HTPBOCiBBOBS: CELOBIHB OBfiUlC C01POUBPS; cnoBoanzztu; rLiOBiis COBTOVIDS; HIITB: 11CCBOLS; THIS; 1DD1TS (ensured at 25 C and 760 an Bg 31. 31 occnmice toner and of per one-siaaa liaita 0.26 and 3.1 Bq/1 lealthy, 18-35 yc old. noaasokieg. nrfcan blaclcs and caticasiana* Chicago. II. Blqilly cant tolled eiptrieestal conditions. IB.EITB: I1CCBOIS: IUI10IS; IDdttS; CBLOSIHTIE BTDBOC1B30BS; TOUTILE CIJIWIC COBtCOIDS; BltlTB B1Z1BD5; 11BIUTICI: BETltOLtSS; aETlSOLITBS: fCPOLiTiot ZIPOSUBB: DBBIB iitis tmntct Coakle. J.P. Caap, B.J. telch. B.». 1975 Itchlves of ZnTlronneatal Health 30 (2): 290-295 Ironean, G.M. O'Helll, B.J. 1979 journal of analytical Toxicology 3:225-23* ------- 2-Peattaoae, a-mtkyl 108-10-1 C6-B12-0 B« 100.2. HP -S».T C. IP 116.85 C. TP 16 ee 1ISSVB •S5» Breath txtosms torn* iBunxcii BETSOB ec/HS BIB an OF CaSES a BlBGB Bot detected-2. 0 ag/g IE1B 1 email. IBPOBB1TIOB 1 I 1 ».2 ag/hr i ceapaaad related to aoiaal 1 tetabolisa. (o other detail ?iiea j Cryogeaic aaapliag techaigae. I 1 Bealtk) ailitary aad cUiliai I eaployees, U.S. air Force school of I lereapace BediciBe. ages 23-«T jr. 3 t fiokecs. 1 \| tlBtini; CBIOBIIHEB BIOBOCUBOBS: ( cnoin orsiBic coitoans; \| CBtOBOtEBZIBfS: flOOBIBE CORPOITBOS: t tBIlTI: 11COBOLS: TZI15: ID01TS SEFEBnCZ conkle, J.P. cup, t.a. ire lea. 9.E. 1975 ircni»« of ZBTinvaeatal Health 30(2\|t290-295 2 ------- 2,2-Oia«thrlactaBol (to 2310-14-1 C10-I22-0 11 158.29 t> caiman . nssn «S7 >tatk moson toon alaimcu RETBOD ec-as ioun or casts 5 (37 staples) 1MG1 lot 9lB asu 0.317 ng/1 MOM trie cuttii iiroiunoi laatsni at 25 C aad 76« la Sg 31.0 oceariaac* IOB«T aad appar oaa-Slou lislta 0.109 aad 0.915 oyl ttaltBT. 18-35 TT old. BOBaaokiaa;. ittai Macks aad caacasiaas. Cklcaga. II. Flqldlr coatcoll«d «xp«rla«atal oaadltioaa. mm; >icoioisj HUMUS; IDIHS: CU.CIIIIT1D BTDBOCIIBOIS; TOIITH.! CIBHIC COBPCT1D3! BBILTH BillBtS: IlBiUtlO: BMISOHS!; HgT>9OlITlS; ICVOUTIOI IINSOH: OBB»» ISEIS - Krotasxiaakl, B.X. Bnneaa. a. I. C'Mill, B.J. Journal o{ taalftlcal Tozleoloaf 3:225-23* I.2,3,3-letr»»»tiTlh«i»ii« (lo postings IB CBCTUI1]. 13«7S-81-5 CW-K2 81 12.32. B> 1«0.3 C TISSUE Bnatk EIPOSOBI POOTI llllTTICIL RETROD GC-KS tnasis or osxs 5 (387 aaaplcs) MI6> lot giT«n Btil \| 1.3 aq/1 GeoMtrie GBIIHL IITOMITIOI e«a»t«4 at 25 c aid 7CO at Bq lenc au4 appac oac-Si^aa Halts 0.35 aad . 8 «q/l KilttT, 18-35 TT old. BoaaaokiBq. aztaa blacks aad ca>caiaaa. Cklcaqo. 11. BiqidlT coatzoll! BBHTB: aicciois; nmois; IDOIIS: CIlOBTlaTn BIDSOCltBOIS; TOUTIlg Cf3i«ic coiicnns: SIII.TB BIIMBS; HIlttTKl; F.3T1BOIIS9; BETaBOlCTIS; EOPDUTIOH tIPOSOIX; T>SB11 UEaS nFZlNCI KiatoaxiasU. B.I. o'i«ill! aljl 1979 Joataal of aaalrtical •torloolo^i 3:225-23 U) --J 2,3,3-TriaBthTla«xaa« (lo postiags in CBZflLIfEl. C9-B2-O t» 12«.2!. It 137.7 C. TP 10.1 aa H«j at 25 c 1ISSOE MW Sratk EIPOS9BE BOOT! nurricn BETHO9 6C-SS lOMSt or cisxs 5* (387 saaplas) nisi lot giT«a Sill 0.730 ng/1 Seoaetcic 6IIIBU IiroiHHIOl e«aaar«4 at 25 c aad 760 aa tq 18.' occarr»e« £c«c aad upper ona-Sloaa Halts C.U7 aad 3.62 aa/1 Kalthr. 18-35 yr old, nonswikiaqj aitaB blacks and caacasiaas. Ckicaqo. Tl. ItqldlT cant colled ciB«rlBBtal eoaditioas. BiiiiB: iiccBois; miiois: inoits: cncnitTZD ETDROCltBOlSj tOUtllB CE61ITC COBtCtTIOS: BEIHB BIHSOS; IIB1UT1CI; alTlEOLISS; BElaBOtltZS; BZ7EIEHCE KOtOBllUBki. B.K. Bcnaaa, S.I. O'letll. B.J. 1979 Joaraal of aaalrtical Toiicoloqr 3:225-23 ------- 2.3.3.-T«traaetarlpeitaae {> postiaas la erasure). 1677—38—9 C«-B2-O (1 128.25. BP -102.123 C, IV 11.551 C fisstrs »6SO Breath Eiposvss aooit IHttTICII. BBJBCD ec-B5 BOBBSB or cjsu 5» (387 •aa pics) MK> lOt ?ina 1 III! 0.39* «9/l Geoaetric ezizsiL nroBUtioi Ea«nr4 »t 25 C aa« 7«0 « Bg 10.»* ocetrreac* Imer and opper oae-Sl«aa liaits 0.113 ana 1.41 ao/1 Kattlif, l»-35 rr «1. oou«o)ti»9. acfci blacks aad caicasianfl. Ckicago, II. SlgiSlT controlled ar«a at 25 C n4 70 aa H<) «. It occarreaca lowr and upper one-sigaa Halts 0.020 sad 0.712 aiHiTic>: RRIBOUSB; BIKEOITTISJ tCPtn»TIO» -IPOSBBE; DBB1B UtlS 1 BlfMMCI Krotosx^aakij B.K. Bruneao, e.g. O'Veill. S.J. 197t Journal of analytical loJicolegy 3:225-23* 1 1 U) U) CO 3-Heptanow, 5-aetarl- 51-85-5 CS-B16-0 F> 128.22, BP 160.5 C, TP 2.0 •• Bg at 25 C 1ISSOB •«62 Breata nvosm! BOOTS mi men BETIOD OC-BS ITB9BIS OF CUES 5 (387 Maples) I»E> Bot firen BB1B 0. SOS BO/1 seoaetric GTiiEiL ziroaaiTiov - leaaared at 25 C and ISO aa Hq 5.27 occvzrence lo»«r aad upper one-Slqaa liaits 0.200 aal 1.27 IKJ/1 Bt«lthT, 19-35 yt o!4, aoasaoklav. ittan blacks and caacasitns. Chlcaqo, II. sioUlr COB trolled eiperiaeatal coaditlona. mm; ucctois; ituiois; IDOITS: CEICBIWIT'D BTDBOC1BBOIS: 10HTHS ClGllIC COttCOtDS: BEtLTl BitlBtS: UBIHTIOH; (mkEOLISB; BIT1EOLITSS: icponnoif EiposaBi: ------- 3-Bexanona. 2,«-diaethTl- i86»i-7o-e CS-H1S-0 RI 128.21. !F 1(5 C TlSSm •663 Breath ZKtOSdBZ E001I ilaLTTICal aiTBOD SC-HS IOBBIS or cisss 5« J3B7 staples) BaISS lot giTen BUI _ 0.311 ng/1 seonetric 61)1111 IirOBBlTIOJ Eeasnred at 25 c and 760 ia He 25. 3% occurrence l««er and npper one-Siqaa liiits 0.134 and 0.«9» noyl BaaltkT. 18-35 -r ol4, nonsaokinq. art an blacks in a Caucasians. Chlcaqo, II. ElqWlT cOBtlollad «pcrii«>tal coadltioaa. EiUTH; 1ICOCO1S; IU.HOIS: ICO ITS; cnoBintiD noiocasmis; SOUTHS C»OJ»IC COBPCOSDS: 9SJITB H12»SES; IIIaLHIOl; inaEOllSH; BITJBOIITSS ; tCrOLtTIOl IIP030IB: 3BBi» 12B1S Bimnci Irotosijuslti, B.K. Braneaa, C8. C'Mill. I.J. 1979 Journal of analytical Toxicoloql 31 225-23 52B-97-2 C€-B12-0 H« 100.16. BP 1SS-15T C TISSUE •66 1 Snath MPOSUJ! M)BT» tSILTTICll \| BBTBOt \| 1 SC-IIS iBBBta i or cisss t S« {387 saaples) 1 BUGS \| 1 lot given Bill 1.1 »g/l Geometric SIIEBaL moiliTIOII \| 1 1 t«asr>a at 25 C a»d 70 ai Bg Ifi. 3T occurrence loner a»a offer oie-Sigaa liiits 0.28 aid 4.3 no/1 Bcaltay. 18-35 Tr old. noosaokinq. oTtu blacks ana caocaalaoa. Ckicaao. It. Biqidlr contcolled €ipccia«iital conditions. ESt«TH; alCCBOlS; IUIIOI5; tDOITS: CBIOBIU1ID BTBBOC1BBOBS; »011TI1B CBCtlltC COBPCOSB5: BEaLTH B1I13CS: 1IH1HTI01; IWTIBOLISB; KSTIBOLITES; EC?aHIIQ« IITCSOIE; OBBH IBEIS 5ETI8EBCE Krotosmskt, B.K. Eraneaa. G.«. C'Seill, H.J. «79 Journal of tnal^tlcal TOilcoloqy 3:22523 3-PentaBoae, 2-«ethrl- C«-B12-0 B» 100.16. BP 1K.S-115 C itsso- a66-i Breath zirasma scan allLTTICal BITBOB SC-BS IVB9EB Or CaSSS 5« (387 saaples) BUGS lot given isTi j 0.86 ng/1 3e one trie GElIBal XITOStaTIOl leasgrel at 25 c and 760 aa Bq 31.3V occurrence lever and upper one-Si gaa liiits C.023 and 0.33 nq/1 Bealthr. 18-35 yr old. no»nokinq. artan blacks and caacasians. Ckicaqo. II. Siqiair conttolled eiperine-tal conditions. fUMTH; itCCBOlS; IHHOIS; 191I.TS; CELOBIWHTED CTDBOCfcBBOBS; TOX&TXIE CtGlKC COIfCnDS: BlllTH BltARDS; I«B»HTIC«; HE/tatoLis^: SEHEOLITIS; tCfOLlTIO* IIMSOttE; H9B1J IBEtS BETEBEBCE K 0 Crimean. G.g. C'Heill, B, J. 1979 Journal of analytical Toxicology 3:225-23* ------- 1M7-20-S C9-B20 •* 128.25. HP -33.11 C, (P 16.17 C iissni •«« Braatk nrosmtE IOBTB iiumcu sc-ss or C1S2S 5 (317 aa>fltaM do posting* la CBgnni). 422-W-1 C»-B2-0 II US. 25, II 1»0.« C Ttsm «««7 Snatk 1 titoimt scant H11TTTCI1 nsrnoD OC-gJ imm OF cms M (37 saaplca) IMCI lot 9! van BUI 2.J »a/l 6«OB«tric e:iicii iiroiuiioi E«amr«d at i5 C a»4 7 SO •• B« 27 7t occvmnc* ICTHK ac< oppr oav-slgw lldts 0.98 • tt 5. 4/l Maltlir 11-35 rr old, BoxaioktiKi. mt» blacks and eaoea»la». Ctleaqo. II. tliltlr contcoll4 «iprlnotal conditions. etziTB; itccms: iirnois: »ous; CnatHHID ETDlOCtlBOIS; IOI1THS cieiiic cospou»ns: SSIITH BIHBDS; IlltUTIOf; RRtEOlISX; «!1EO1ITKS; iopnt»no» ixrosmR: »>» IBIIS i BEmncz i ! Kcotoaxj-nati, S.S. Brao«ao, C.I. O'latll, S.J. 1»79 Janrinl of Inalytical Toilcoloqr 3:225-23* U) - o 4-MptaaoM 123-W-3 C7-BU-O BW 11. 1. Bt -32.6 C, It 1M C nssn »«€8 Braatfc sifosffBS soon inirticit BITSOB GC-BS Boaia OF CJSJS 5 (387 saaplM) SHIS Bat giT«a - 1 B3H 1 0.07* BJ/1 Je Metric cEiiBtt mossinoi B«aaar4 caaeasiaaa. taica«o, 11. >io.lily conttollal «tp ------- t-leptaaone 123-14-3 Cl-iW-O Bl 11». 18. UP -32.6 C, BP 1« C (CORIIVBD) ITS SOB »«» VClM nposm BonE Serial lIUITICtL BROOD OC or CUBS a» IS b> «o BIKE 4) 0.01-1.5 sg/g CreatinlM b) 1.5-3.7 sj/g creatlBiaa _. am a) lot gives b\| lot glres Gil till XIFOIBMIOI ' •) Costrola b) forkers eiposed to chloropheaols Inkers lit h«rblcll« laaufaetirlna (lint. BfSBICTDBS; HBOSTMU M.1JTS; cccaptTioiu Btzugs; rssriciDis: icmuTiof Bitosoii: CBLOIIBI OBGIIIC ccBPovns: IBKOU: cmoi: mm BZnBBlCB T«B Boeotian, P.B. n«Ln, i.i. 1980 International ireUvu of Ocnpatiaoal and EiTironaeatal Health •5:57-62 C12-H1-} It 186, HP 300 C •«TO Blool, plaan MTHOO or cisss 1 - BIIGE •ot glTea BEaB 0.133 »g/l CEB1I11 IBTOIRITIOR j C Aayi after 50 •! dilited grancoiie 39 jt «ia, aildto atteipt. El»p«««, r«nl f allot. fallUq forces Tital capacity. Imeitel urea, eteatliiie. Etotelanrla, hrallie east IB itlie, (eiiUlar ofaeities. aziBICTDES; tBSTICIDBS; BLOOD PtlS'Tl: S1ICTDI SBBBICB Eose, J.D.B. 1990 Lancet 2(1200) :92* OJ a.T-Bethanolndan. 1,2.»,5,6,7,».8-octachloro-1.2-ep«T-3«.«,7,7a-tetr«tiYdro- (( CD 2,S-!)eth»o-2B-iBdeso(1,2-b)oxirese, 1a.2,3.s,S.Ca.7,7-oct«cUazo-1a.1b.S.5a,«,«a-t 26880— a8— 8 It m.n •671 111k BETBCn GC OF ClSSS 1«« _____ ins: 75.4-11S.3 ppb . 8E1I 95.8 * or - 195.1 ppb GE«tBL HTOB9ITIOI " Ccipited OB fat aallit«J basis lanoe ot Maaa for all geoqiapkie < agios cinio siHisj minis; mi; ceiptBuiTE mmriois; caioain CfSHIC COBPCITIDS; HSIDBII; VISTICIOBS; tlCTanOI IERBETCE " Sarage, E.P. Eeefe, T.J. Tessarl, J.D. •heeler, a.«. applekaaa. T.E. Goefl, E.I. ford, s.i. 1981 laerlcan Joarnal at Ipilesiolog} 133 («) :«13-«22 ------- a.7-!!etlianoina'an. 1,a,5,C,7.8. 8-heptachloro-2,3-epoxT-3a.a,7.7a-tetrahvdro- (8 CI) 2,5-8«thano-2H-iideiio(1,2-b)oxireie, 2.3.B,5.«,7,7-heptaehlora-1a,1b,5,5a.6,6a-hexahvdro- (9 CI) 1024-57-3 C10-BS-C17-0 II 389.32 TISSUE 4S72 Adipose 1673 Adipose 1 1 1 1 4674 Hi Ik 1 1 1 •675 111k ETPOSOBE BOO! Ingestton AIUTTICAX, HETBOD GC GC GC BOBB5B \| BABGE 0? CASES \| 1 1 1 1 1 1 1 1 1 1 f 1 1 1 1 1 1 1 1 1 1 1 1 60 \| <0. 05-11.? 5 pp. 1 1 1 1 1 1 21 I » 0-0.296 ppl 24 1 b) 0-1.902 ppl 15 \| c) 0-1.002 ppl 45 I d) Mot given 1 1 1 1 1 1 1 1 1 1 1 6 \| 66.1-128 PPB 1 1 1 1 1 1 SB»» \| GIBIBAt IITOSBATIOB 1 EEFEBIHC! 1 1 1 I 1 1 I Scviev f Deichaann* V.8* I \| McDonald. I.E. 1 Expose! persons IB the United states. I 1977 1 the Netherlands, Sweden, Israel, \| Ecotoxicologv and 1 Japan, BSSB. Polaad, Geriany, India, 1 Environaental Safety 1 Enlgaria, Pakistan, Austria. 1 1:89-110 1 1 1 deported cases of hypertension, 1 I elevated serai cholesterol, abnanal I 1 EIGs, or iapairaent of nenrcnscular 1 1 fnctioB after acate exposure to 1 I calcinations of pesticides, but lost I 1 Icng-terB occupational exposare. j 1 1 1 lOSTBit; BOLGABIA; GEBBAii; noil: i I ISB1EL; JAPAl; HETBESIAIDS: PAKISTAI; 1 1 tcLiio: BOSSII: SIEDEI; DIIIED i I si »i is: IDIFCSE nssijJ: BLOOD: BLOOD I \| FIlSBl; BIOCC SEflOB; EBTTHBOCTTES; I \| IIDKOCTTES; BILK; OBIXZ; BETI5W; I \| BI11TH B1Z1IDS; OCCtlPlTIOIU B1ZUD5: 1 \| FCPOUTIOM BIPOSU3E; HIOPLJSBS; \| \| FESIICI3IS; CBIOBIIE OEG1IIC 1 \| CCBPOUUDS \| 1 1 I 1 0.38 ppa f Peripheral kidney fat, routine 1 Oejonckheere, ff. I cathological exaaiaations I Stearbant, 9, I 1 Terstraetea. E. I Iqes 6 ao-92 yr. Belqiua 1 Kips, F.H. \| \| 1978 1 EiiGloi; BIOPSIES: IDIPOSE TISSUE: \| Toiicological European I eioCCOnniTIOB: PISIICIDIS; DVD; 1 Research 2(21:93-98 \| ttl: DDT; DlttDBIl: BEPTtCBLOR I \| ffOHDt: BtXlCtlloniSEIZEIl: LI (DIKE; \| \| CELORUB OBG1HC COflPOaiDS \ 1 ' ^ 1 1 0.017 ppa I a) Baral anthers, fat basis 1 Pozo Lora, B. 0.051 ppi j c) urban Bothers, fat basis I Herrera Barteacbe, ». 0.035 pps \| c) 111 Bothers, fat basis I Polo Tillar. L.n. 0.0003 PPB 1 d) 111 Bothers, nhole ailk basis 1 topez-Giienez, I. \| Cata for son of all pesticides and 1 Jodral Tillarejo, l-o ------- «,T-Bettanoindene, 1,t.5.6,7,8.8-heptacliloro-3a.»,7,7a-tetraoTdro- (8 CI) I.I.S.S.T.a.S-beiptachlaro-aa.a.T^a-tetraliTaro- (9 «t 373.35, Ht 95-96 c, Tf 3TIO («-») H Bq «t 25 C Tissue «67« "ilk ZXtOSTOE B001! 1 tngestion a>U.tTICU MTtBOB GE R09B3B OF C1SES b) 2» 0 «5 d) «5 IMS! a) 0.405-10.823 ppa b) 0.615-11.686 pps c) 0.1105-11.686 pps d] lot given a) 2.556 ppa b) 2.«62 pps cl 2.505 pps d} 0.0390 ppn GtltElL IlrOSIlTIOl - a) Bural lathers, fat basis b) Urban Betters, fat basis c) 111 eotaers, fat basis d) 111 eotaers, vnole ailk basis Data for svn of all pesticides and ^caparisons vlth valoes of other investigators given •ntslnq notnecs froa Cordoba region. Sraia SFllI: IBDtTSj BILK; CSLOBIH OieiflC CORTOraDS; EISTICntS; KSBICUtTTOI: CIIU 11I1S: OBBII tBElS BEfEIEICE Pozo Lora, B. Becrera Earteache, a. Polo Tlllar. L.9. Lopez— Ginenex, •• Jodral Tillarejo, S. Tglesias Perez, J. 1919 Sevlsta Espanola de fedlatria 35 (206): 93- 110 5-»ortora«»«~2.3-4l»ethanol. 1. »,5, S.l.-T-heiictiloTo-. cyclic s«ltlt« (8 Cl> «,9-Ktbana-2,K.3be«zoa.laitiii«paii, 6.7,«,!.1l),ia-»eiicla»ro-1,5,5a,«,9,51-terahiiro-, 3-0tide \9 CI) II5-W-7 C9-B6-C16-03-S •• •06.'). flt 106 C, n 1I10CI-5) as Bq at 25 C Tissni \| 1 vhole EXPO&llfiS RODTB mtmciL i IHTHOD \| GC-EC or CISES a) 35 b) 12 0 36 d\| 12 1U6E a) lot detected b) lot detected c) lot detected 1) tat detected nil a) lot detected b) lot detected d lot detected d) »ot detected C.IIEUL IIIOSBITICI a) Tniodan I, Love canal residents bl Taiodan I. volatteers c) Ihiodan II, Ion canal residents i) Tbiodan II, vol«ateers lisit of leasnreaekt, 0.23 n<)/q for •thlodan I and 0.32 aq/q for ThioSin II CloaelT aatcbed, slanltaneoai control ta spies ere aot provided for aaelrsla alooe witk those froa tie 36 lacklmq neaninqfsl control or literature data relative to the significance of the lo residues fcnnd in the field saaples analvud, DC definite conclusions can be dram fees the results reported. lesiieats of tew Toil. Controls, eiplovees of the laviranuital Erotection Iqencr a«d university itid«9t8. fcrth Carolina. Ill T01K: tcm cuoilll; WOOD; Bi»aenm BROODS; CHICHIE oiGinc CGBEOanS; CtLOBOSElIUM; cipmns; roeounoi EIPOSIH EIIIBESCI Bristol. 0.». 19BO II1-«00/1-80-036, ao pp. 1 OJ ------- 345 DRUGS ------- (1, 1-3iphenTlJ -m-bntanoic acid, gasea-oxo- 3H30-85-5 C16-BU-03 RR 25.3, at approx 180 C TISSUE •678 Blood, sen* Urine - EXPOSURE SOOTE Ingest ion Ingestion, 1 Hit men L HETHOD HM.C HPLC HOBBSB OF CtSSS 26 26 -. B1RGE a) Rot giT b) Rot giT c) Hot giT J) Rot giT e) lot giT f) Rot giT ' a) lot giTen b) lot giTen c) Rot giTen d) Rot giTen e) Hot giTen f) Rot giTen 1 R!ll 1 «) 13.7 * or - 5.3 b) 8.2 * or - 7.9 ag/nl c) 80.1 * or - 13.2 ug/nl d) »5.8 » or - 22.5 e) 0.7 t or - 0.3 ag/nl ?) ».2 » or - 2. 1 ug/nl a) 1.9 » or - 5.8 ag b) 1.6 » or - 3.6 «g c) 1.8 » or - 2.0 ig J) 7.1 « or - 16.8 17 e) 13a. 6 » or - 61.7 f) 5«. 1 + or - «9.7 Gzimi iiposiiTioR a) Rornals (creatiniae clearance >80 il/min). measured as unchanged fenbafem t) Benallr Impaired (creatinine clearance 3-20 ml/min) , measured as fenbufen c) Roruls, seasnred as gaiia-hydroiyt 1. 1'-biphenyl]-l-butano ic aciJ (metabolite II) d) BenallT impaired, measured as metabolite II e) Rormals, seasnred as acid {metabolite IT) f) BenallT impaired, neasured as metabolite It Peaks, after 100 ng fenbufen, single dcse Data also for other metabolites and ether degrees of renal impairment 51-87 rr old patients and controls. fasted before and after dose. ORITED KIRGECR! IBUITS; KIDRII DISUSES; EICOD SEBIJI; II11GISICS: IRTI-IRrLinBIIOBT IGERTS; HTIPIIEIICS; DBDSSJ COKPallKITB ITIUJITIORS; BET1BOIISB; HETIBOIITIS a) Rormals (creatinine clearance >80 il/iinl , leasnred as unchanged fenbufen t) Benally Impaired (creatinine clearance 3-20 il/nin) , measured as fenbufen c) Rornals, neasured as qamna-hydrcXTT 1, I'-biphenylT-l-fcutano ic acid (metabolite II) d) Benally impaired, neasured as Ktabolite II c) normals, measured as ••-hydroirM.I'-tipbenyl T-n-acetic acid (metabolite IT) f) Benally impaired, measured as metabolite IT Peaks, after 800 mg fenbnfen, single dcse Data also for otter metabolites and other degrees of renal Impairment 21-87 yr old patients and controls. fasted before and after dose. 3SITED KIRSDCR: iDULTS: KIDRET EISHSES; 31000 SEBUfl; UllGESICS; JUTI-IHFLftRHlTOPY KGE1TTS: IKIPTBBTICS; 9OGS; CO!IP»B»TITE ITJItHTIORSj BET1BOLISR; RETM01ITES SEFESEBCE Bogers, P.J. SaTitsky, J.p. Glenn, 9. Spector, B.C. 1981 clinical Pharmacology and Therapeutics 29(1) :1»-« Bogers, H.J. Sarltskj. J.P. Slenn. B. Spectar, B.G. 1981 Clinical Pharmacology and Therapeutics 29(1):7«-\|o Ul ------- Icetallde, B-aaidino-2-(2.6-dich!.arpBenyl)- (» CI) Ecnzeneaeetaaide, I-(aiinoiaino>etliyl)-2.6-dlcliloro- (9 CI) C9-H9-C12-B3-0 HI 216.11 TISSUE ETPOSIRB- BOUT! JHLTTICJI BETSOD •680 tngestion SC-PC Blood. cells ( 1 1 1 1 1 (DEIZB OF OSES b) 10 1 1 1 I 1 •681 \| Ingestion GC-EC a) 9 flood, \| b) 10 plana I f 1 1 1 1 1 1 t \ t \ 1 1 1 1 1 1 1 1 1 "682 \| Ingestion GC-EC 1 Trine \| a) ? b) 10 i( bl IMGE 1.EA. SEBM.L WrOBBmOR I EEFEBEBCE 1 1 a) 5.6-0.91 ng/al a) Bot given a) Erytnrocytes, 3 and 36 kr wans 1 Seiss, I.I. D) 11.n-1.55 ng/«l b) Bot given after 2 «g. Initial .easureient 1.12 1 Lavene. B.I. ng/al at 1 hr t\| Erytarocytes, 2 and 36 br aeins 1 Safar, B.E. 1 Siaon, I.e. after 9 ag. Initial aeasureient, 5.1 \| Loria, I. ng/al at 1 hr ) Estimated froa graphs. a) 3.48-0.69 ng/al b) 8.28-1.31 ng/al a) vot given b} Bot ?ivea 1 1 J 1 1 f 1 I 1 1 Rot given rot given a) 29.9 » or - 2.5 of dose b) 3". 3 » or - 5.1 « of dose 23-59 vr olds, no drag > 4 vk before study, 100 leg/dar a diet 3 days. Ill had c&ronic hypertension without cardiac or renal involvement. Reduced blood pressure. CSOG5; DBDG TBEEaPI; 3IPEBTSBSIOB; JBJHCEJ BLCCD PLtSHl; OBIRtj BLOOD ISISStTBE: IBITHBOCTTIS; COBPaBanVE IftlDlTIOBS a) Deans, 3. t and 36 hr after 2 ag. Initial xeasureient, 0.76 ng/d at 1 kr t) Reans, 2.C and 36 hr after 4 ag. Initial neasareaent, 3.59 ag/al at 1 br Cata also given for steady-state values after 1-3 ag 2!/day. 23-59 yr elds, no drug > D vk before study, 100 leg/day Ba diet 3 days. Ill had chronic hypertension vithout [JUGS; 9RUG UTERI?!; HYPIEIMSIOH; TB1BCE; BICOt PUSH: UBIBE; BLCOD IBISSBBB; IHIHPOCITES; C08PH1T1TS mnjTtons i) 2 ng dose t) 4 a<7 dose 72 br caaulative excretions in unchanged foci. 23-59 yr olds, no drug > » «k before study, 100 teg/day Ba diet 3 days. All ha4 chronic hypertension vithout cardiac or reaal involvenent. Bedacel tlood pressure. BIBGS; DIOG TBIBIPI: HIPISIEBSIOB; tsiBCE: sioor PLisni: OBIBE: BLOOD ;«SS!!SE! fSIIHSOCtTES: CCBPAB17ITE 1 Georges, D. B. 1 flllliez, P.L. 1 1979 1 Clinical Pharaacology 1 and therapeutics 1 25 (3): 283-293 1 I 1 1 1 1 1 I 1 Veiss. I. a. 1 Laveae, D.L. 1 Safar. S.I. 1 Siaon, I.e. 1 loria, T. 1 Georges, D.B. 1 nilliez, P.L. 1 1979 1 Clinical Fharaacology 1 and Therapeutics 1 25(3):283-293 t 1 1 1 1 Veiss, T. t. Lavene, D.L. Safar, I.E. Siaon, i.e. Loria, T. U) -IS oo Georges, D.9. ( nilliez, P.L. \| 1979 \| Clinical Pharaacology I and therapeutics 25(3):2M-293 ------- Acetamide, 2-(p-(2-hydroxy-3-(isopropylamino)propoiy)phenyl)- (8 CI) Eetzeenacetailde. 1-(2-hrdroxy-3-( (1-methylethrl) amino) pcopoxr)- (• CI) S9122-68-7 C11-B22-H2-03 n« 266.31, HP 106-148 C TISSUE 0683 Blool, plasma 9664 Blooi, plasna EtPOSUB! ROUTE Tngestion Ingestion AHALTTICAL METHOD HP1C HOTIBJB OF C1SES 12 BARGE ' 716.1-50.5 ng/lll 1579-15 nioles/1 SEAS Hot applicable Hot given GEBIBAL IHPOBBATIOH Heans, 1 and 24 br after 100 ag. Initial value, 243.5 tig/ml at 0.5 hr. sab-fects at test. flcalthy 20-28 yr olds, no cardiac, renal, hepatic or absorptive abnormalities. Bo medication > 15 days, fasted overnight. Besting systolic pressure negatively correlated vith drag plasaa level. r=0.521, p<0.01. Heart rate. systolic pressure, plasna renln reduced, correlated with plasoa drug l«vel. p<0.05. CflOGS; BLOOD PLASHa; BLOOD PE5SS095; S COLTS; HOSilCDES 2 and 40 br leans after 100 ig/day Bealthy 20-3C yr olds, vithin 1OT of norial velqlit. 9edaced resting and exercise heart rates. Reduced blood pressure. CBOGS; SBHDIS; B10OD PLASH); UTIBTPSSTESSIVE AGEHTS; CODPJBJT1TE IVALOATIOHSi ADD1TS: BLOOD PEESSOBE BEPEEEHCE liner, B. Hason, H. D. Carter, C.R. willoaghby, T. 1. Kochak. G.I. Cohen, I. Bell, B.B.S. 1979 Clinical Pharnacology and Therapeutics 2«(3):315-325 Johansson, S.B. HcCall, a. vilhelnsson, C. Tedln. J. A. 1930 Clinical Pharmacology and Therapeutics 27(51:593-601 cetamlde, 2,2-dlchloro-!i-{beta-hydroiy-alpha-(hydroxynethyl)-p-nitrophenethyl)-, D-threo-(-)-, (8 CI) cetamlde, 2,2-flichloro-H-(2-hySroxy-l- (hydrotymethyl)-2-(l-nitrophenyl)ethyl)-, (B-(B«,B«)) - (9 CI) €-75-7 11-B12-C12-M2-05 « 323.11, (IP 150.5-151.5 C TISSOE 1«S5 Blood, plasaa 9S1H Elool, serum ZIPOSIJBB ROOT! Ingestioo Inlection aHAlTTICAL BETHOD GC GC 5DHB5B OF CASSS 1 a) 8 b) 5 BINGE 11-23 ug/ml a) 11.2-36.2 ug/rnl b) 10.0-36.2 ug/ml (BEIT 9EAB Hot applicable a) Hat given b) Hot given PAGE) GEBIBAX IRPOBHATXOH Initial measurement and 1-2 hr after 50 ig/kg, IT daily as paloitate. 16 nq/il at 6 hr. Measured after 7th dcse. After hvpophysectomy, 30 yr old vith haemophilus influenzae type b leningitis AULTS; IHFECTIOB: BLOOD PLASBl: C?BEBB05?IH»l FLDID: SSTIDIOTICS; CHOC TOEBAPT a) Peaks at 15-50 mgAg/day b) Peaks at 25-50 mq/kq/da? Ion birth Height infants, 1 vith tacterial infections, a) Ages 1-8 d. • t 0.9-2.5 liq, gestational age 25-35 vk, and b) ages 11 d-8 vk, vt 0.9-2.2 kq, gestational age 28-31 vk. ETHHSTlTaHIA; INFANTS; HE1EOEH; BLOOD S!B01; SPIHAL FLOID; ANTIBIOTICS: ttiOG THEBIPT; CHIOEIBE OBGJHIC CCnPOURDS BEFEBEBCE Bensimer, E.B. Pickering, I.E. Ericsson, C.D. Kramer, w.G. 1991 Lancet 1(8212) :165 Glazer. J.P. Danish, H.A. Plotkin, S.A. Samner J.T. 1980 Pediatrics 66(1): 573-578 ------- c«ti«H«. 2,?-«lrt,lor»-«-(« t-'J'r-T • J?J.1«. (IF liO.S-UI.S C 1 1 i""" ! fl«U 1 i i i i i i < i i • Spinal \| I 1 1 1 1 t 1 1 a-kj aroiT-alpti- ( rtTtn X sc kr«lroii»«lt'U-!'-iUr=,-i««. »fcrl)-. :>-t»r»o ,eo. l or c»5« 1 ( f 1 1 lot applicable _ 1 -!-)-, (8 CJ\| rifsrsj •?>i _ - (ti lg/Iq, li •iiilT a; oil>lta«. 3C TC ill «Ub hanaphllni icflntnza* •rniTS; IPFBCTTCH; BLOCS PLJSRI; f3G vnve«pr ' ~ ' 60 lin iftrl dos« f25 itj/kg/dar in 2 ?«roi 1«T«1. 10. f nq/al F!1«SriT»»II; I»Pl»ri; JJHP09"- BLOOD S[«tH: SPI«»[ fltllB; i«TJ?I01ICS; CCRPfOMSS f ._._ . 1 ««"'« rri«r, V.G. Gl«z«r, J-p. E«nish. S.Jt. riottir, 5.4. Su>«rr J.T. Pediatrics Actloo]. IIPOSOII! ItOOTt It)9*t ion OIL B • !JII»rB or c»ses •) 7 b) 6 XMGI » 1.65-0.3 tq/tl b) 7.3-1.5 uq/.l 1 ~ niti 1 1 1 l Kot gir«n M Not qir«o t CFItPfc&t IMFORR&TIC( 1 1 1 l Contrail. ! «n1 2« hr «(ttr 200 I 11. 7nitl«] BeReurcMint, O.t ui/il 1 4t t br u<;/il «t 1 he Mtiiat«d frci qCKph •!•»» kq. )2-40 rr oil p«tl«nt». HlOIfll: HTPrBIE».51C»; FID»II cisr»sf.TiHTp!«re»;Tr» norics; DMC iPt»«»T: ne»cor«Lrsis l r;pc»5»c* Hftrvvnqt, c. P»n«q«r. J.P. HuscKart, J.n. f»rb»«c)l, n. >?7? Journal o( Ciintcal ------- Icetanillde. 4'-h7dro»y- (8 CI) aeetaalde, H-(g/l a) 14-43 ag/ml b) 0-5-13 ug/ml c) 180-9 aayal (HER 1B4H 7.23 « or - 6.33 139.22 » oc - 64.57 ng/dl ... a) Hot applicable b) not applicable a) Hot applicable b) 6.7 «g/l a) Hot given b) Hot given c) Hot applicable P1GE) GBBBBSL IBFOBBITIOS textropropoiyphene poisoning fatalities, alcohol and/or other drugs in lost cases. Ccroners cases, ages 16-67 yr, northern Iceland ccaa, death. congestion and edeoa of lungs. In sone, cerebral edeaa. [BROS; BLOOD: VBIHB; SUICIDE! DBDG HOSE: ISE1UD CeitraproFOXychene poisoning fatalities. Other drugs found in peat subjects. Hcithern Ireland Coaa, death. Cengestlon and edeaa of longs. ID Ecie, ooretcjl vdeia. tBOGS; BLOOD; OBIBB: SOICIDE; OBOG HtVSt; I8ELIBD a) 90-210 iln after 13.93 ig/kg at 2 18 t) 90-210 nil after 13.93 pgAg «t 6 18 Bcnoeipoaental decay. 5s ti Bated fro» graph. Bealthy 22-32 yr olds, fasted before ind daring eiperlnent. Ho drags 1 v* before stady. BEOGS; 8BTaBCLIS8; » DOLTS; BLOOD CIlSHa a) 24 hr values after a single 4 g dcse. Peak at 2 hr and then decline. Considerable individual variation 1} levels at Sth day following tvice B«althy 21-67 yr olds. «t 48-100 fcg PEI1BCB; 1DOLTS: BLOOD: BLOOD PL1SIH; IBtlGBSICS; JHTI-IBPLiBBlTOB! JCS8TS; SBJLGtSTCS; JHTIfTBBTICS; D1TO TBEBtPT: III VITBO aNlLTSIS; DBOGS a) 0.5 hr after 30 ng/kg dose t) 4 hr after 30 mq/ltq dose O 4 and 16 hr after 250 ig/kg lose 0.5-6 yr olds vciltlnq early symptom of overdose CBILDBBE; LIVES DISE1SZS; BLOOD Htsn: »B«tGESics: DRUGS; HEALTH BIZlItDS BEPEBEHCK Carson, D.J.L. Carson, B.D. 1977 Lancet 1 (8017) :894-897 Carson, D.J.L. Carson, B.D. 1977 Lancet 1 (8017) : 894-897 Shlvely, C.a. VO3O11, E.S. 1975 clinical Pharaaeology and Therapeutics 18(4)1413-424 Callleai, p. Callleni, 1. illsln. p. Benler, J.-c. Therapie 34:81-87 Peterson. R.6. Buaack, B.H. 1981 archives of Internal Hedicine 141:390-394 ------- icetanilide. H'-hydroxy- (8 CI) Acetaiide, H-(H-hydrolTphenil) - (9 CI) 103-90-2 CS-H9-S-02 BS 151. 16, 9t 169-170.5 C (COHTIROED) 1 1 Tissns »6»5 Urine ««96 Urine 1 9697 1 Urine r 0618 Heine «6M flriae EXPOSURE ROUTE m»ITTIC»l ITOHBSB HETHOD 07 CiSSS Ingestion HPLC 8 1 1 Tngestion IP 17 1 Tngestion 1 1 1 1 1 1 13 12 1 < 1 » 1 8JBGE a) 7.«-27. 3 mg b) 13. 0-25. » og C) 26.5-171.0 ig »2. 0-255.0 »g 1.30-122.00 •g/dl 137-425 ig/dl a) 0.90-3. 89* of dose b) 4.6-16. 8* of dose 0) 36.7-61.8' of dose i) Not applicable b) Dot applicable ;) not applicable BE* I \| GIIEB&L IHFOBB1TIOH I BEFE2EHCE 1 1 a) 16.5 mg b) 17.6 >g c) 81.7 mg d> 170.8 ig 27.01 » oc - 36.29 •g/dl 1 1 1 a) Free, 6-3.5 hr after 11 dose I shively, C.I. I b) Tree, 0-8 hr after IS dose 1 resell, E.S. j c) Gluoironidate. 0-3.5 hr after IS I 1975 1 dose \| clinical pharmacology 1 c) Glucutonidate. 0-8 hr after a* ! and Therapeutics 1 dose \| 18 (»\|: it 13-1121 1 CmulatiTe cicretion after 975-1,300 I I «q. t l i I tcfore stqdy. t 1 1 I HUGS; 1ET1BCLISH; ADMITS; EIOOD I 1 ClftSHA \| 1 1 1 \| 1 Deitroorof oifphene poisoning \| Carson, D.J.L. 1 fatalities. Alcohol and/or ether j Carson, E.D. 1 drags is tost cases. 1 1977 1 1 Lancet 1 ( 80 17) :89«-897 1 Ccroneus1 cases, ages 16-67 yr, I 1 northern Ireland \| 1 1 1 Coia, death. ( 1 scie, cerebral edeaa. \| 1 I I BEaGS: B100C: HEIST; SUICIDE; DHUG \| I IECISE: IBEUHD \| I 1 221.54 t or - 83.19 «g/dl a) 2.43^ of dose b) 12. 8« of Hose c) »7.6% of dose a) 0.06 ig b) 0.58 ig c) 1.03 ig 1 textrapropoiYphene poisoning \| Carson, B.J.L. I fatalities. Other drags found in r Carson, E.D. •cst sablects. \| 1977 1 lancet 1 (8017) :89«-897 Coroners1 cases, ages 16-67 jr. \ northern Ireland \ I Coaa, death. \| Congestion and edeia of laogs. In I sate, cerebral edeia. I ! ESOGS; BLOOC; HEINE; SUICIDE; DBDS I IEOSZ: I5ILJBD \| 1 1 a) Onietabolized drug \| LeTy, G. b) acetaiinopben qlacuronide f Khanna* N.N. c) acetiiinochen salfate I Soda. D.n. It hr cuinlatire excretions after 12 1 Tsuzaki, o. • g/itg ( stern, L. f 1975 Healthy 2-3 day old, foil-ten I Pediatrics infants. \| 55(6) :818-825 1 ISOSS; OBI1I; SEHBOIISS; HESBOBM; I StI I 1 a) AcetaBinophen \ Levy, G. 1:) acetaainophen glucaronide I Garrettson, L.K. c) lcetaiino;hen salfate I Soda, D.n. CuiQlative eicretlons 1st 1».75 hr of I 1975 life. Aether ingested 0.3 g I Pediatrics 55(6) :89S phenacetin S.5 hr before delirery. t t Healthy nevbcrn \| 1 osncs: MidBcts: osm-, -(ET»BCIISB; i EBEGBiSCl; CUSE HISTORIES \ 1 Ul ------- Ice tic acid. {2,J-alchloro-0-(2-thienylcarbonyl) phenoxy) - 00180-00-9 C13-H8-C12-04-S US 331.17 TISSUE 4700 Blood, sera a BIPOSOHS BOQTE Zogestlon avainicu BETHOD ec BOUSES OF C»SSS 6 BiBGE _ a) 0.63-0.55 ng/nl b) 2.35-H.68 ng/ul e) 1.01-3. 6B ng/al 4) lot given el Hot given fj Sot given •Ell a) lot given b) Rot given c) Hot given 4) 0.34 • or - 0.17 (SI) og/nl e) 0.55 « or - 1.20 (SB) cg/al fl 2.83 * or - 0.59 (SB) aq/il GB1EMI, IBFOBIUTIOH e) Days 3 and 4 b) alcohol Mtabollte. days 2 and 4 c) Diaeld aetaboUt«, days 2 and 4 d) Dncnanged drag e) llcohol Mtabolite {) Dlacld netabollte a)-e), 8 11, fasting saaple before 250 ig. d)-f), attar 5 hi henoaialvsis on day 4 Inephcic 21-50 vr olds, on beiodlalrsis >12 aoBtha, controlled diet lo effect o« else in serno gcic acid after dialTSis DIOOS; DBDS THEBIPT; ISROBIUTSIS: DIOBETICS; 8IUBOLITES: KDBZT tlSMSIS; StCOD SERDB; PEBB3TH»1IH BBFZBEHCE •array. T.«. Brovn, S. Dnbb. 3.9. Bvang, B»t» Stote, B.B. 1460 Clinical Tharnaeology and Therapeutics 2T(5\|s««6-«89 acetic acid, («- ------- acetic tell. (a-{allTloxr)-3-cklacopae;irl\|- C* CI) BeBzeawcetie acid. 3-calorc-«-(2-prope»jloirt- t» d) J2131-7»-» C11-«1t-Cl-03 Rf 22C.CS, IF M-93 C TlSSVt •783 Oriae mosns JODTJ lt«*U«» ininicit 8C imBJS OF CaSSS ) 32 14 W met a) lat glvea b) «.8-»S.7 eg I mi a) 50.4 a? b) 4. 2 eg etinai ziFOBamoi a] SOD «7 a nspeuiai, overalgfct faat t) 1000 n la cipnle at aeiltlee Caaalatin 2« be ezcnetiaaa, EvalthT adelta BtWSS; IBTX-lrFlftaflafOBI A€ZVTS: trtiPTsnics: BICOD plasm; aeitt IERCSTCZ SeueUe, L.t. Sa&dera, B.C. Frieiaaa, 1. Clielcal PkacMacolagr aad Tk«np« Hot 9itea f) rat ?i»a 6FIIBH ZrFOIIlTIOI •1 2 kepatoaa petleats, dase a5 ao/cq a t\| a aoa-kepataea patimta, dese ac-as nj/sq a c\| 3 fcepatoia patients, deM 30 ao/«j t d\| a noa-baratoat patieata, dase 30 ae/aa • e) a hevataaa patieats, dase 15 ag/aq a f) 1 aaa-lwpata»a patleat, daee 14 0 «»J 25 kr, estiaated Dcoa qrapk* Cata availatle far eetabolite. <-71 re aide >itk kepatoaaa aid «tkec aeoplaua »I6S; CBlgOlBSaaPT: CIBIBCSIS; IIOFIISIS; EtOOB t>I»SHa: COBP1BITITE •11101TIOIS; BRtBOIITZS; IDOITS BIIISCTCI Ckaa, It.S. Cklebeeski, I.T. Tong, 8. Ckea, B.-S.G. Croas, J.F. Bateaaa, J.I. 1980 Cancer Beaeacch «0:1263-126« ------- tUiia. 3-(B-(bls(2-cUerotBrl1aBlao)p>eiirl-. I- <» CI) 1-PkeirlalailM, a-(W(J-cbloro«tkTl.\|aal«o)- (9 CI) 1M~82~3 C13-V18-C12-I2-O2 HI 305.20, BP nppcox 177 C (decOBp) »706 Blood. plasaa B70T Blood, plasaa. »78B TJEiBe 709 Vrtae ntosan sooti Injection Xagestlon Injection IneeetloB tlliTTICaL HETflOD IndloaetCT BPLC BPLC BFIC mnns or CUES 11 11 IMSE 3.0-0. OSS «g/Bl a) 0.07-0.63 ag/nl b) 0.18-0.31 ag/nl 1.5-21.6^ «f dose •I 2.»-21.»« of dose b) S-1CX of doe •Ell lot give* a) 9.29 « or - 0.15 b) 0.31 * or - 0.11 •1/Bl 13.0 * or - S.a« of Aoae a) 10.9 » or - .9f of dose b) 13.2 « or - 3.7 of dose et limit motiaiioi ladlau. 0-6 hr attac 0.6 •«/»« IT. Ilexponeitlal decay. Ertiaated fton 4Upk. Cancer patl«Bts, aqa* M-70 IT, t a3— §6 kg E«I«S; CIE10TBEI4PT; 9UEE: HOOD illSBl: IEOPI1SBS; IISEISES: IftMOLITES a) 11 nblectc. nftar 0.6 ag/tq, aa t) 3 aubleeta. nftec O.t B^Aa. a aclatlon Vaake 29-70 yr old cancer patients, t «a-\| k« tines: CMicnBiin: itomsBS; nooi (iisii: it HI: conautiTE tfiinitiois 24 kc accretion aft«r 0.6 a^/kq caaeer patient. a«w «-70 it. at as-a« k« MOOS; cmoTBztini VIIIE; noon CI1SI1; ISOH1SBS! DISMISS ; tKlBOtlTES a) 11 aab-\|«cts. after 0.6 ag/tq as tablets b) 3 a abject i, after 0.6 sa/k« as aelitlon 2«-ne exccetioBs 29-70 TE old cucec patienta. «t ««-«< kg DfOSSt CBnOTIEBMT: KOPLaSBS: B100B msti: mm: COIBUTI«E ZTllVHIOVS BETSIEICI llberts. B.S. Chang, S.T. Cken. B.-S.O. Evans, T.I. rarner, t.U Ilsnelatein. K. Cross, J.r. Cliaeal Paarucolofr and Tberapevtlcs 26O):73-M tlberts. b.S. Cku?. S.T. Chen, H.-S.B. CTBBS, l.l. Boon, T.E. 1979 Clinical Phacnacologj and Thecapaatics 2t(6(:7J7-7«5 tlberts. D.S. Ghana, S.T. Cken, B.-S.5. BOOB, I.E. Evans, l.i. ramr, B.t. Blanelstel. I. Gross, 3.1, 1979 Clincal Pnarnacology and Therapeutics 26(1): 73-10 alberts, b.S. Chang, S.T, C&ea, f.-S.S. I rans. I.L. BOOB, T.I. Clinics 1 CharMcologr and Therapeutics 26(6):737-TI5 ------- alDna-f t-n-Olo-I-isoiDdolinjDphenrllpropioaic acid (go postings in CREILXR) . TISSIJB (710 aiooa. plasea IIPOSUOT BOOTS Ingestion I i Mi-men, SET HOD GC BWWSB OF CiSIS 1 MUGS a) 1.0-7.5 ng/al b) 6.0-0.7 ag/«l Hill a) lot applicable b) Hat applicable eziiMi, moBUTiai a) d-enantiover 0.5 and 1.5 lie after 200 mg cacaiic aiKtare. Final leatnnaent, 1.8 ug/il at 10 hr H 1-enantloier. 1 ud 10 hr after 200 • as btoiida. 61/iaf iTastkenic patieot. U.S. MOGS; BLOOD 9USU; SSiSDSIKIT 8ITBODS: OflTID KIISD01 EHFESIBCB DlTison, S.C. Ffman, f. Prentis, S.I. Dehqhan. 1. Chan, K. 1980 Methods and Findings IB experimental and Clinical Pharmacology * <2) -.77-62 Ui liiontai, (o-bro«obeniTl)sth7ldi«etbfl-, p-tolaenesilfonate (8 CI] I«neB«etkaraainin«, 2-bro»o-Ii-et!>Tl-».1l-4i«etiTl-, salt »itb a-Mtkilbenienes»lloi.lc acid 11:1) [9 CI> «1-75-6 C 11-B17-Br-».C7-ll7-03-S «« «!».», HP approi 98 C IISSOE •712 BlOOl, scna EIPOSDE? SOOTF Tnjection laoestioa illtlTlCil KETIOB SC IDBBn OF ClStS 10 B1WGE a\| 38-13 «?/«i b\| 1134-2«36 nq/al I»1W a) 76 ng/al b) 1896 oq/ll GEiieii T»ro«ai7io» •) Feat after 5 «o/g, oral t\| Peak after 30 «ln IT. 5 i^Ag lealthT. 20-«7 rr olis, Michigan iniietTr fleshing, eiclteaent. increased blcod pressare and heart rate, liTTio«ss, nasal congestion. transient headache aid nausea in EC a. (ICBIGIH; 1DDLTS; BLOOD SEIOfl; IT5I1E; IITTHTPnTIlSITf 16ERS; DHOGS; CCIPlBlTItl ETJUOlflOKS BBFEREBCE Inlerson, J.L. Patterson. 1. (aaner. J.G. Stevart, J. B. Beha, n.l. Incchesi, B.3. 19BO Clinical Fnamacolog7 •ad Therapeutics 23(«):««8-«7» (HIT P1GE) ------- insoiinn, ro»l>e«nietnTl4lBethTl-. p-tolaenesnllonate (6 CI) BeareneaetlLanaBlnivB, 2-broao--etn7l-t,-dinetBTl-. salt with 1-neUiTlbanzeiwsalfonic add (1:1) <9 CI) 61-75-8 C11-H1T-Br-».CT-HT-03-S n »1».a. IF appro »8 C (COtTMMDJ TISSSS • 713 Blood aerui »7ta UriM nposuas ROJII Inlection Tngastioo Zn faction Inaestion IHITTIC11 HRHCD ec-sc EC WDHBIB 1 or cisss aj 6 M 7 10 I USE a] 2.5-0. 08 og/sl b) 72-»61 ag/ll .. a) 0.3-0.9* DC dosa b) 0.1-P.2* of dose BSII a) lot applicable b) 1»« tg/ml a) lot giYen b) lot glTBB GIKBIL xnOlMIIOI ») Initial muuaMat av4 2n hi altar 5 >g/k tosTlate Ociiae patients, «-77 ji all, oral thecapr after 3-7 days ol IT thicapy. Tulabla, aostlT postural. bytoteaslon litb oral tkarapy. ItDlTS: CilBIOTISCTUlB BISHSSS; t!IST DISUSIS; BLOOD SIBDB; iiTiiBEaiianjc lerats: DBOG TSBBIPI: CllSntKHR IREOOS a) Beak a IMC 3D ala IT. S aa/kg t) P«at aftet S t-ci/k-?. oral HtaltM. 279 OJ InillM, a.a'-salfonTlil- (8 CI) Mni«Mailn«. «.>-siilfonTl1>ls- (9 CI) SO-08-0 C12-H»i-»2-02-S H 2»».30, »P !75-t7« C TISSDt •715 31ool, scrat EXCOStnt! BODtE In«eatlon tlUTTICU IWHOB riioroaetty gOSBIB OF C1SES 6 1»GI a) 2.5-0.1 19/1 b) 3,0-0.02 »g/\ cf 2.0-0.07 •?/! fl) Z.S-0.03 «g/l a) 15-0.5 mg/l I) 10-0.34 j/l Kll j. a) vot giTeo b> Tot gi¥en el Tot gli«n }) lot giren e) lot giten I) lot gireo CtltUI. HFOBHITIOI al Dapaan dose 100 ag/day, 5 dars ------- iBiliae, «,«I-sslfo«Tl4i- (> CII Beimteaslae, »,a'-salfonTlbl»- (9 CI) (0-08-0 CTJ-»12-»2-02-S If 28.30, IP 17S-17S C nssn »7M Or IBS cxposm IODTB laeestios aiaimcii •craoi) rlioroeetry •HUB OF C1SIS « Hies i) lot given b) lot given e\| lot gina d) lot given ) tot applicable f) (at applicable szi» i GintiL iirotnnoi I i •) 16.C » or - 1.1* \| •) tavsoae. «oe 199 eg/daT, S dar of Aw* \| (ttam 1) b) 9.9 » or - O.SS of I 1} after 118 9 activated charcoal lorn \| 10-58 he after last dapsoae dose e) 6.3 « or - O.M of \| (rkase 2) too* \| c) 9oaa>»tTiaapaoa«, phaaa 1 i) .2 or - t.ZX of \| l\| amotetTldf>s--clil0ro-2-((2-facaaylMt)iTl)"li'O>- (9 CT) C12-»f1-cl-»2-O5-J 9> 330.77, BP 20C C CO Ui oo IIJSOB «7I7 Blood, plasaa nrlae Exrosras torn Injeetloa laJeetioB 8TTIOD DC SC-JC JOBBBS or cuss c 16 1IICB a) 750-604 nq/al b) 7SO-tS8» ng/al a) 22. « 0-73 .4. of lose b) 3.]-ao.« of dose c) 0.13-3.92* of lose inn BUI i GEKUI urotnnoi 1 i a) lot gives I a] Initial acasareaent aid 2.5-3 fcr b) Hot given I after IT kolas of TO ag, then 1 coBtlneons lafnsioa of 8 ag/hr 1 b) Initial eeasareaeat and several hr I attar 1 gs crobexcid IT 2.5-3 hr 1 after start of iufnsioa I !«se valves tstlwted fro* gnph. 1 BtalthT 22-2t rt olds, welqkinq 7« « t or - 8 kg, fasted before dose. 1 1 sacked diuresis 1 I noes; SVZDEI; TUIIE; BLOOD 111911; 1 BlntmCS; BIOS IREMCTIOI; lOfllTS 1 a) 56. 0* of dose \| a) Oichaiged faroaealda b) 10.784 of dose I t) Contagated fvroseaide c) 1.88* of doae \| c) Icid aetabolite aadlans 1 21-hr caaelatlv* ezeretions after 1 2C-UO «g farosuid* Iseaa dose * 1 «7.2» gl. 1 1 2t-88 Tr olds «ith ante pvlaoaarT 1 edesa, «t ».»-100 kg, sose OB other 1 liags, soae with acote avocardlal 1 itfacction. 1 1 tunes; atTiBcusa: BCTIBOLITIS; 1 CIIIOI; DI01RICS: tM5TOE»n 1 EitMDS: BBIIT oiSBisss: aim: 1 ccapitHTUt EuimTiois: IDUITS; MUG I Tinivr ( •a6B\| fiBTSBERCX Odllad, B. Beernaan, S, 1980 Clinical pharaacology and Thenpentlcs 27(«)s78S-790 Fetei, J. Sltar, D.S. Ogilvie, (.1. 1979 Drag Retabolisa aid Disposition 7(«J:383-38T ------- littmllle acid, a-chloro-B-farfnryl-S-selfaeojl- \|« CI) ieaiole acta. -faeiaonlfoiyl)--chloro-2-((2-feraaylnethyl)aBiao)- (9 5«-31-9 C12-B11-C1-BS-OS-S 81 330.77, 8P 20C C CI) tlSSBl •719 Brine nposviB ton* Injection IMITTICH. BSTHOD ec BOBBES or cisss 6 1UGI a) 2.86-3.21 ng/30 ill b) 1.75-1.25 if/30 (in mi ) not given b) lot given. i Gzitaii iiroiitnoi . i) Initial Btasicmeat and 2.9-3 hr •ft«t IT bolus of 10 ng, then contlnnons infnsion of 8 ng/hr b) Initial aaanreaeat and several ir after 1 qm probenecia IT 2.5-3 he aftur start of lifasloB Sea Tala«« catlaat! £COB qraph. I«althT 22-21 re <>14», nlgUaq T« or - B a, fasted before flos. sar«4 ainreals Dines; sinzi; nr»; BLOOD ntan; D MIMICS: DSOS mnicnoi: IBOITS nnmci oaiiaa, B. Beermii, B. 1980 Clinical Phanacology ai8 Tkrap««tlcs 27(«)s7M-790 (• CI) 3H-rrr»»ol-3-on«, 1>2-ai>raro-1.5-aiMthrl-2-pbmrl- (9 CD $0-80-0 C11-B12-12-0 81 188.22. RP 111-113 C 1ISS8S «720 Blool. plasaa »721 Bloo4, plBSBB »722 Saliva Mfosoits toon Isolation ' lB4StiOB lagastioB •IlLTIICaL 1OTBOD HI OC ec , IOBBBS or cisss 10 11 11 . Hies a) tot given b\| Bat glan c) lot giT«B A) Bot giT«B •) BOt giT«B f) lot given 11.5-26.0 ng/Bl 12.5-29 ag/il (BUT ni a) 2.21 ag/al b) 2.18 «g/al O 1.M »9/sl 4) 1. M ag/il e) 0.5 ng/al f) 0.35 ag/Bl Bot given Bot given MG1) 6SBI1U IITOIBMIOI a) Control ai«t - 3 hr r) trnssels cpoBte «»4 catbage aiat - 3 nr c) Coatrol diet - 9 hr i) Ervsels tpronts a4 cabbage 41et - 9 hr e) Coatrol diet - 30 hr f) Brassels (pouts «n4 catbage aiet - 30 hr 1) Dose »as 1.8 nq/kg 9-30 hr valves sigalficantly aiffereat 21-32 vt old. »t 50-79 Itg. icnaaokers, fasted before and after dose. mass; gins; BIOOB PLISBI; inuoinis: coBPUtnvx imainoBs Peaks. 3 hr afer 18 ngA? Talne hiqhlr correlated vlth saliva valves. BoBoezponeatial decline. Istlnated froB graphs. Eaalthr adnlts. aqes 22-30 rr. ItOHS: BtOOD PLIS81; SUITt; iiiicesics: jiTiPTsmcs: Dives: CClMBlllrj CTIlIITIOfS Peaks, 3 hr after 18 ag/kg. BOBoexponential dec 1 lie. Zstlaated fres graphs. (ealthv adalts. aqes 22-30 vr. ltD»s; BIOOC PltSITl; S11IT1; liaiGBSICS; anipnZTICS; MUGS; CCTtlBITITS Et»LO»TIO5S KniEBCB 1 I PantocV, B.J. Pantack. C.B. Garland, B.a. Bll, B.H. Batten berg. 1.1. anderion, K.I. Kappas, 1. Conner. »-H- 1979 Clinical Pharaacology and Therapeutics 25(1): 88-95 Vesell, E.s. Passananti. G.T. Glenvrlght. P. ». Dvorehik. B.H. 1975 Cllaleal Pharaaeologf and Therapeutics 18 (3) -.259-272 Vesell. Z.S. Passananti, G.T. Glenniqht, P.I. Dvorehik, B.H. 1975 Clinical Pharaacologv and Therapeatics 18(3): 259-272 Ol VO ------- latipyriie (8 CX) 3B-Pyraol-3-one. 1.2-dih7dro-1,S-dinetkTl-2-pkeiiyl- (9 Cl) 60-80-0 cn-ai2-»2-o HI 188.22, HP 111-113 C (COITIIOED) TISSUE «723 Brine EIPOSI1BT ROUTE Tngestion lIUlTTICm HETHOD TIC <3C •DHBS1I OF C»SES 1 H1ISE a) lot applicable b) lot applicable c) lot applicable •Ell at 33 of dose b) 17* of dose c) 17* of dose GEMIU IIFO1BITI01 i) la •-kydrexrantierrine t) Is 3-aydroxyMtliylantlpyrine c) Is lorantipyrine 0-50 ar cneelatlre excretion after 1 g 70 kg, vkite asle pkenotyped as "poor •ataboliier" according to capacity to t-kydroxylat* debrisoguine aid sparteine. DSDSS; ggttBOllSn: gSTUOlXTES; OII«I: COSP151TITE ET»10»TIO»S: SfDITITBS; BTPBOTICS; iBTIPIBETICS; IITIHT?WTE»SIYE 16MTS; IITHFBBIIHBIC 1GKITS 1 BEFZRBRCI Inaba, T. Of ton, 5.T. Kalov, V* 1980 Clinical Pkariacologr and Therapeatics 27t«):5»7-5»9 IBtlpyTlae. »-(di«ethTlaaino)- (8 CI) 3B-Prrazol-3-one, H-5-aiaet]iTl-2-phaa7l- (9 CD 58-1S-1 C13-B17-113-0 HI 231.2». BP 107-109 C TISSOB «72» Blood, plasia »T25 eiood. plasia •726 Saliva 3XPOSm>I FOOT lagestioo Ingest ioa laqestlon KlXTTICItl MTHOB GC oc sc iOHBSS OF C1SES 12 « 11 FJKGB ». 5-6. 2 ng/Bl a) lot gireo b) lot glTeo 1.7-7.6 og/»l mil \| GEtiui iiroiflinoi I i Hot glrea \| 3 be after 9 Bg/kg. 3stiiated froa \| gtapfc, \| KaltkT adults, ages 22-30 jl. \| 1 EDITS; BIOOD PllSHl! SUITl; \| H»ieiSICS: MTIPTBETICS; BBOGS; \| CC'PIFITITE irilffHtORS \| a) 8.01 » or • 2.52 1 a) Dose, 2 ig/lcg at 8 >.H. aftec •g/1 kr \| 12-hr fast b) 7.96 * or - 1.13 I b) Dose, 2 igAl at 8 P.B. after •g/1 kr j itnal aeal at 5 P. a. I liea under tbe carve for free * bound I drug \| ffcalthr 22-31 yr olds, wt 59-85 kg \| PHKSTLTiKU: »DOLTS; BIOOD FllSlil; I IHIGtSICS; IITIPIKBTICS: DHOGS; I CCIPIRITITE miomofs: DIRS 1 1 Hot given \| 3 hr after 9 eg/kg. Honoexpoaential \| decline. Rstieated fron grapk. I ecaltkr adults, ages 22-30 rr. 1 I It HITS; BIOOD PUSH; SUITl: I IHlGtSICS; HTIPIFETICS: BFOTS; \| CC8PI1ATITJ mlOlTIOIS BKFEBEBCE resell, l.S. Passanantl, G. T. GleaRlght. P. a. Drorchilt, B.B. 1975 clinical Pkariaeologr and Therapautics 18 (3>t 259-272 Sbirelj, C.I. sinons, B.J. Passaaant, O.T. DTorekik, B.F. Tesell. t.S. 1981 Clinical Pbaraacology and Tkerapentics 29{1):«5-73 Vesell, t.S. Passanantl, G.T. Glenvrigkt, P.I. DTorekik, B.H. 1975 Clinical Pkanacology and Tkerapeatics 18 (3) J 259-272 ------- Barbitaclc acid. 5-(1-eyclohe«en-1-Tl)-1,5-dl»ethvl- (6 CI> nil) 2,l.«(1».3H,5in-PTrlsidinatrione, 5-(1-evclahex«n-1-yll-1.S-diMthrl- (9 CI) C 12-B1S-I2-03 •I 238.26, SP 15-17 C 1ISS1! 727 Blood, plasaa «728 urine txrosoif soon Injection . Infection II1LTTIC1L WTHOD GC GC IOBBIS O? C15BS 1 at 6 b> 11 BUS! _ a) 4.3-12.8 »g/l b) 12.8-2.0 ig/1 a) lot given b) tot given cj lot given d) lot given mi a) lot applicable b) lot applicable a) 02.3 or - 13.6 * of dose b) 12.6 » or - «.1 « of dose O 0.31 t or - 0.13 * of dose d) 0.33 » or - 0.2« t of dose GEI1B1L tirOIBlTIOl al 5-60 a la infusion D) 0-720 aia post-lafasioa Cose, 556. 2 ig (7.32 ng/tql as sooin salt. Biezponentlal decay. 60 vr old hepatitis patient. DSTISS: BCTaBCLISB; IDOITS; CCHP«B1TIVE HVIIOITIOSS: OBIITi BLOOD PUSItl: LlttB DISUSES a) controls, 3>-fcetohexobarbital t) Patients, 3-ketohexobarbital c) Controls, nnchAaged dreg dj patients, snchanged drne 2-hr cuniilative excretions after i. 97-7. 32 eg/kq as sodium salt. TV. 17-t2 vc oil patients lth ante kepatitis, healtbr controls. 5S1SS; BtTkBOLlSH: 1DOLTS; CC9P181TIVE rrilnitlOKS; tISHE: BLOOD PtlSSl: 1ITIB DISUSES tmsEici Breiaer, B.O. I ill. «. Richter, 1. 1975 Clinical Pharnacologv and Therapeutics 18(»t :»33-»»0 Breiaer, D. D. ZillT. . Itichter, I. 1975 Clinical Phanacology and Therapeutics 18(«):33-aao EarBitaric acid, 5-ethTl-5-(1-nathflb«tTl)- (8 CI) 2.«,B(19.3R,5H)-CYrlliiiiietriOB.e, 7e-7»-» C11-H18-I2-03 US 226.31 UJ 1ISS9! «7» Blood a730 Blood. plasu 8731 liver riposns! soari ._ - . - - 1IH.TTICAL KETEOD SC HHHBI5 OF CiSES 1 - « 1 — -- BlIGE lot givei 2-7 aaoles/1 lot given BE1I 1 »g/ml S. 25 uiolee/1 52 ug/g eiifiiL iiroRnnoi titopsT staple ** Tr old pharaacist, suicide. cverdose of ether drags OB3GS; DSTC IBIS!! 3DTCIDE; 1DTO95TE3: ClSZ BISTOBtES; tUS11BlB»I RETHO9S; IEV ZEIllXI; EIOOD: LtTEl; OSIIE; ItlDNSIS; BDIIK; ItCCHOLS 36 he after last of tea, 0.1 q daily doses at bedtiae. »OBS«okinq 23-37 TC olds, «lth no evidence of disease or drag intake. DUDES: HWH8O11SH: SKTSES: BiPEiinisioi: BIOOD PUSH; DBOG IlrnaCTTOI; 1DOLTS; COHPi»a«TE imoaiiois AntopST aaaples 44 yr old pharaacist, saicide. overdose of ether drags CETCS: DBUG IB3SI! SltlCIBZ; lOTOpsus; CSSE HISTOSIES; !ftlSDBE!(!1fT BETBO95: DEI ZEItMl; iiocD: LiTti; D?I»E: KIBIITS: BRII! IICOHOLS ixjsastcs . Qneree, E.a. Oickson, S.J. Ussen, i.e. Pannell, L.K. 1979 Journal ol inalytlcal Toxicologv 3:253-255 Collate, p. Seideean, P. Borg, r-O. H&gltno, I. von Bahr, c. 1979 Cliaical Pharaacologr and Therapeutics 25<«):23-127 Oneree, K.I. Dicfcson, S.J. nlssen. 1.7. Pannell, I.It. 1919 Journal of Inalrtical Toiicology 3:253-255 ------- larbitarlc add, S-ethvl-5-lsopentvl- (8 CI) 2,a.C(lB,3H.SR)-PvrinldiBetrlone. 5-ethjl-S- (3-nethylbllt C11-B18-B2-03 If 22C.2T. BE 156-158 C )- J9 CI) •732 Blood. plasna «733 urine T3« Brine ngeatioa aiunzcit anioD or/as ec/ss IBBBSB 0? CUBS a) S b\| 5 el 5 9) 5 1 67 11151 ' "MB 1 B1IIS1I, nrOSBUIOf 1 1 1 1 b) or3S-5."2 Jig/al \| b) 2." 53 If/Il [ I) iMnatls (coVds} of ^ " 1"' "* c) 0,591.5 ng/al I e\| 1.16 ng/al \| c) lothecs, 60-110 nq phenobarbital 8) 0.26-1.2 ug/«l \| d) 0.82 .g/nl \| daily » 1 dose asobarbital aoring 1 \| labor f 1 d) Weonates (cords) of e). 1 1 1 I 17-42 IT olds, treated «ith I \| tartltarates for hypertension in I \| pregnancy, and their nenbora. I \| »OGS; SBWBOBB; PBEGUBCT; I \| BTPBBTBBSIOI; SEDHITSS t 1 1 1 a) tot applicable 1 a) S9t of dose (70. « \| a) Is 3-hTdrczTuobarbltal b) lot applicable \| at) I t) Is anobartUal-I-glncopymnoside 1 b) 12< of dose (1«.» \| 0-100 hr cotolatii excretion after I ag) \| 120 ng t I 1 \| 10 kg, unite nale pbenotvped as "poo 1 I Mtabollxer" according to capacity t I t 1 i-hrdrozvlate debrisoqnine and 1 I icarteine. 1 1 1 \| DBBG5; RBTlBOLISa; »ST1901ITIS: 1 \| OlIIE; COBPIIITITB ITIIDITIOIS; 1 \| SfOaTITBS; BIMOTICS: »»TIPHBin:S: 1 I UTiBiPiBTiisiyE tsnrs: 1 I I«IH!»HTTB!!IC 1SCTIS 1 1 a) lot given 1 a) »6.1 * or - «.7 \| a) 29 Orientals, b) lot given I nnoles/1 1 3«-nrdroiyasobarbital (aetabolite) c) lot given \| b) 59.3 * or - 2.1 \| t) 13S Caucasians, d) lot given I aaoles/1 \| 3<-hrdroTTaiobarbltal e) tefsiven \| c) 39.1 * or - 3.1 \| c) 29 Orientals, f) lot given \| inoles/1 j l-(beta-D-glacopTranosrl) anobarbital g) lot given I d) 29.2 * or - 1.5 I (aetabollte) 1) lot give* ( neoles/1 \| a) 138 Caucasians, 1 e) 59.5 * or - 2.8 I l-(beta-t-glocopTraaosrl) anobarbital 1 aaoles/1 1 e) 93 Caucasian sales, t t) 58.9 * or - 3.8 \| 3<-nTdroxya»abartltal 1 anoles/1 \| f) «5 Caucasian sales, 1 g) 27.3 * or - 1.6 I 3l'hTdroxyanobarbital 1 ONles/1 \| g) 93 Caucasian nales. 1 h) 33.0 + or - 3.0 \| 1-dMta-g-glneenyranosyl) aiobarbltal 1 uaoles/l 1 b) 5 Caacasiaa females, 1 s.B. \| t-(beta-o-glocopyraaosyl) anobarbital 1 \| lto«t 36 hr aftec 60 ag anobarbital. t \| Oriental and Caucasian Mdical 1 \| stadents. < 1 1 \| CBBGS; ICIK STOBIBS: SKIBOLISIT; 1 \| CCRrillTITZ miVlTIOIS; OHIBJ StTC; 1 \| IITABOLITZS: C1B(D1 ' 1 «««,« Draffan, S.H. Dollery, C.T. Daiies, D.s. Kraner. B. tllliass, r.E. Clare. S.», Trndiager, B.J. Darling, 1. Serial, B. Havkins, D.E. 197C Clinical Pharaacology and Therapeatics 19(1)t271-275 Inaba, T. Of ton, S.T. Kalov, V. 1980 Clinical Pharmacology and Therapeatics 27 («): 57-59 Tang. B.C. radar, 9. Bndrenyi, 1. Chan, T.-1. 1979 Clinical Pharaacology and Therapeutics 26(6) : 76-776 1 ------- larbitarlc aclJ, S-etafl-S-PaenTl- (> CIJ Z,a,«(IH,3H,W)-PTri«idi»etrionB, S-ethyl-S-paeByl- (9 CIJ 50-06-6 C12-EI2-B2-03 •I 232.23, SP 1T4-1T C 1XSS1B »735 Slool. plasaa 737 Blood, Btasaa •73 BlOOd, plasaa B731 Blood, serna 1IEOSOS3 BOOTS Ingest IOB Tngestion 1BH.7TICM. iznoo EC sc ec/is HPLC »OS8BB or cuss i 36 a\| 70 b) 39 6 12 B»ez cot given 10-37 ng/sl a) lot given b) lot gives a) 1.38-2. »0 ag/al b) 1.23-2.25 ttg/al a] 12. 0-25. » ng/1 b) 13.3-24.7 ng/1 c) 17.6-23.1 ag/1 Bill B BS/Bl vot given a) 11.05* » or - H.89 ng/il b) 9.097 * or - 10.10 ng/nl a) 1.90 * or - 0.36 b) 1.68 * or - 0.38 a) ot applicable b) lot applicable c) Tot applicable 6IIZU1 IiroiBlTIOl totopsy saaple • 4 yr old pnaraaclst, salclde, overdoses of other drags DSB6S: BSOG ISO 51: SUICIDE: imopsits; cist msiosixs: BHSmtmiT RETRO9S: in IIIUID; nooi: IITBI; DBI1I; KIDIETS; BKUi; ITCOTOtS Paspeclfted dally dosages. pegvtlvelv correlate «itb plasaa reala concentration, r» -O.a«7, p < O.D05. 15-55 yr old epileptics, on pkeBobarbital > 3 • oaths. CBies; inicosTOisaits: BLOOD tusxa: iiscoisn a} Rales. 2-> he after 1.15 * or - 1.»H aq/tq t) resales, 2-* kr after 1.16 * oc - 1.703 aq/tq tatients on aainteaanee doses for selzues. iBiiconTDtsarrs; woe IHIBIPI; BLOOD EIJSFH: S»; DEOS inSBlCTIOl; a) thcBobacbital, 60 ng %) Pbenobarbital, 60 ag, plas valprolc acid 4250 ag 2x/day starting • flays before) a) «ad b) not different, p > 0.05. loraal 2VMO hr old Caucasians, free cf any drag. tines; aim; inHacnot: isous: S1CCD PLlSRti SIBIIITSS; ITPKTICS; mTCOITVLStRS; IRT&3OLIS!! a) Means, after 1.J-1. * eg/kg/May, IVflay regiaan, 10 snMects t) Beans, after 1.3-5.6 ngAg/day, 11/day reginen, 10 subjects c\| Beans, after 3.«-5.6 ng/tg/day. 31/dar reginen, 2 snbjects 1-3.3 yr olds, infrequent seizures mm; BIOOC SCSOR: CBILBE!>; DBTSS ainmcE Qneree, E.a. Olckson, 5.J. Blssen, a.I. Pannell, L.K. Jonrnal of Inalytical Toxicology 3:253-255 Booker, H.!. Gooatrlena. T.I. Tevksbory, D.a. 1S7» Clinical Pkanacology and Iherapeatics Schaeffer, 9.J. Janardan, (E.G. Sonani, S.fl. Zaston, O. Sbernaa, D. 1980 Toxicology and Applied Pbarnacology 53:35- 36 Fatal, I.H. Levy, R.B. Cntler. B.I. 1980 Clinical EKarnacology and Therapentics 27 W.S 15-521 Valsoa, t.D. Rliaki, T. earless, P. nayersohn, 1. Perrler, 0. 19SO Journal of Pediatrics 97 (2) : 303-305 (HIT PaGZ) LO ------- larbltaric acid, 5- 1 1 Dickaoa, S.J. f • jt oia thn»dat, sniciie, \| Hlssaa. l.'- 1 o«rlo3«s of other drags t Pann«ll, L.K. 1 1 1979 1 HOGS: D0S 1BHSI; SDTCIDE: I Jaurmal ol Inalftica). 1 IOTOP5ISS: CIS! RTSTOHISS; I ToiicOlogT 3:253-255 I nusmsmT IRHODS; in ZEILJBD; i i siooD: LITSR: mm; KIDIIIS: smii; i 1 tICOBOlS \| 1 1 1 t ) Rot applicable \| a) Mans, after 1.3-a.a .g/ig/iaT, I Salson, P.O. ) »ot Applicable I 21/aay r«qi«e», 11 subjects I RiaaU, T. 1 rot applicable t t) Beans, after 1.3-5. « a4/t4/lar, f Cnrless, I. 1 1V4a? r«gi»««. 11 anhjeetB \| Rarersohn, •- 1 e) Beans, after 3.4-5.6 •g/kg/Aar. 1 Perrier, D. 1 31/itj Ttgiftn. 3 subjects \| 1980 1 1 Joacnal of Peaiatrlcs 1 1-8.8 ft olds, infrequent seizures I 97 (2): 303-305 1 SHTTi; BlOOt SZ10R; CBIlDSKi; D»IG$ I 1 . \| OJ Eeazaaite. a-(acetTlaaino) -»-(?-{diethylaaino) ethrll- 327»5-a»-1 C15-S23-B3-02 • I 277.11 1 TISSUE 1 I-- 1 •7«3 siooJ. elasaa ETPOS088 B00TB 1 0 1ec t ion lutnmi i insBM BFTHOD \| OF C1SSS HPLC $ BliGE 24-45 n?/«l SZ4M 30.7 ag/aj. 6EIEBU IfFOKIaTIOl (caks, 30 ain after 15 ag/kg, IT. TciezponeBtial decltae. Istiaated froe graph. Dialysis increased total clearanc a-fold. FnactioaiallT ««phric 33-5« TT olds. lo side effects. DB1GS; BLOOD PL1S91; 1DDIIS; CISnS!Sl TI1IKOIS; COSPIBITITE MtlDtTIOIS tun USB) tmttfcx stec, G.P. ItUison, l.J* Kevin. S.J. Theaot, J-P. EUO, T.I. Sitsoa. T.P. IianoTich, F. del Greco, T. 1979 Clinical Pharmacology and Therapeutics 26(51:618-628 ------- Eennside. «- (tcctrlulao) _»- (2-g at 50 ig/iii, IT. contlaooBS axponentlal tecllne. !«tii»t«d fcoi frapb Coge as hi4rochlorl4e. 35-38 rr oldl, fasted before aid after dose* to effect on pvlce rate, blood preasmra at electrocarlio^taa. CftUGS; BLOOD PLISSI; TL1IIOIS; «lSlT»ME!rl HFTBODS: DBUI; 1DDITS 2* tr urines after «2«-(«3 q, oral. and 5 tin 11 o£ 2SO aq. Dose as hylroelilarlde. 35-38 yr olds« fasted befoze and after dose. lo effect on pnlse rate, blood picH«re or eleetneardlograi. ipifGS: BIOOD ptisni: ILLI>OIS: giismism Hitnos; OHIII; IDUITS pinmct strong, J.n. Oa tclier, 3.S. Lee, B-K. Itllnson, 1. J. . Jc. 1975 Clinical Phareacolocji aal Therapeatlcs 18(S)<.613-«22 Stroncj, J.H. Ditcher. J.S. lee, «-!(. ttkinson, k.J. , Jr. 175 clinical fharaacoloqj and Tlerapeotics 1« (5) J« 13-622 Eeitlenepropaaaelna, ?a« 10-89-3 C17-B18-'3-«-O 81 309.33 TISSUE »7B6 Blood, plasaa titosatt tone - Ingestion immcu BBTHOD SC-JC •DBBE3 OF CUES 4 - SHOE a) lot given b) lot given - a) 1«7 ng/sl til 87.5 ng/nl a) forflmietine Mtebolite. days 17-30 tl fluoxetioe, dars 20-30 tose, 30 aa/daT for dars 1-7 and 20 ng/dar foe days 23-30. Steady state levels. loraal, 21-50 Tr olds on nodified. enteeholaiine-free diet. Vedaced platelet serotonin levels and uptake. lo adverse side effects and no bekavioral effects. INKS; IBDIln: B10OB PIISHI; mmms; IIVLTS: SBIG inEncnoi _ _ _ Lenbetger, 1. Sonet B. Cartlchael, ------- Eencanesilfonnlfe, 2-chloro-5-(1-hTlroxr-3-oxo-1-isoini!ollnTlt- fs CI) leat«asilfonaaide, 2-chloro-5-(2.3-dikrdro-1-lijarorr-3- i esiEML iwroiamom i swEiBircs l i i i a) O.t27« ng/1 1 i) SO •4 6 he after t Tv«e£4ale, B.C. 1 tto 190 ig tablata. Oet«ctabla at 1 I Oglltle, E.I. 1 he. rival Masnieieat, 1.5 »g/l at 5 I 17) 1 s. \| 1979 1 1 Clinical Pbaciacologr 1 8«altBT 20-32 rr oils, rt «5-88 tg, I ani T),erapc«tics 1 fasted OTenight. \| 25<«) : 806-812 I icnss; Diapmcs: IETHIBHIDS; i 1 iroLTS: OBIVZ: BLOOD PUSH i i i i \| at given I Daily «zccetlan after 190 ig/dar for I Tweeddala. I, G. 1 > 1 math. { OqllTie. I.I. 1 I 197« I Reapitalized lea. \| Journal of 1 \| Mtaraacentlcal Sciences 1 C1HDI; OS1GS: RIlSITHBIirT BET HODS : \| «3(7) 1 1065-1068 1 EIOOI; VRIIE; 1 BOLTS \| _ _l ) Emolc acid, p-(Uproprlsalfa>arD- (8 CI) teizaic acid, a-((dlproprlaalno\|salfonrl>- (» CI) 81 285. 3«. «F 191-196 C 1 TI5SVE • T51 Slool. serai ElfOSDE! IODTI Inoestioo 1 AR11TTICU RETiioD or CISES 3 HVGX a) 21-116 ag/al b} 25-154 ay/ml Mil a) 58.7 ag/al b) 71.7 ig/al EE«mt ITPOtnTIOl a) Before •et«otrecat« b) Ifter 15 ila IT of 3.0 g/sg a aethotrexate sttrtlno on day < steady state geoaetrle aeaas 12 hr before - 21 fcr after aethotrexate. 1.7 g/sq n prebeneeld giTe* la t Jl Tided doses. Cancer oatlents, ages 20, 2«, and 7 Ti. la toxic effects. csoss; Dins incitcTioi; ------- Kittle ada. p- «ipi«JTls«li»»OTll - (8 CI) Msolc acid. 4-f(41proprlaaliio)s«lfoiiTlI- (» Cfl C13-1H-1-O4-S If J85..3S, BC 194-1« C IISSOI 4T!2 urine EXTO31BS KODTft ' Ineestion lIlLTTIClt 3KTOOD _ iinsa or cisss 3 I1IGE 12-34 of dallr « lot given tally excretion ou 1.7 q/sij a in 4 aoses/lay. unaffected daria 2-crtairph«iTX eater !«2-9»-J C1»-«1»-OS II 256.23. HI 230 C ilSSDS 4753 Blood, plasaa SIPOSBW tout! 1 1 laoertio. llltRICtl . BPLC •IJBB!S or c«s!s i UISE - - 0-33.4 aa/>l SUI ----- •at gives ei«i«i iiroMiiici i 1 « &m« 1 kr after 1000 a-3.>-dit>rdEoxT-, [-)- (9 CI) ffl- (9 CI) S1-4I-2 C8-«11-» Bl 16. 16, IF HI C (Jecoap) tISSSI 475* Blood. f I I BIPOSBH lodtl iiumcii. RET8OD . Intyiatlc OF CASK _. . 12 sues • a) Cot ?lven b) lot gi«a (Will mi a) T50 » or - 66 na/Bl b) 349 or - 34 n^/el e> 51 » «r - S a^/al sx PIGt) eiicut iiroiunoi t a) 4 kr after Hose b) « kr aftet dose el 24 hr after dose Simile 100~a9 dose BcaltkT 20-21 Tt oVfls, no carilac. renal, kapatic oc absorptive ataarsalitie. 10 eeiicatlon > tS aars. fasted oveiDlght. lelaetia 1« sfstollc blool pressvre. beart rate, and plaaaa real* activltT. Increases la plasaa acrepincpkrise at rest and daring exercise, tttectf correlate »lth ing level aaf last at least 24 hr. giTiGS: stooc pus^i: BIOOB ;nssmt^: IDVLTS; ROEIOnS nmtiCE liner, 1. HasoB, l.D. Carter, c.R. SllloaqhbT, T.I. Koctak. G.I. Coken, I. Sell. S.H.S. 1979 Clinical HiaraacologT and Therapeutics "26 (3V 1 3 15-325 ------- teazrl alcohol. alpha-(aalnonethvl1-3.4-Uhviroxv-. (-)- (8 ci) t.2-Be»MdioI, 4-(2-a.iiLO-1-nrdtarvetlivl\|~. {81- {• Ct> C8-H11-1-03 B> t«9. ia, Rf 19! C (decosp) (Coming) IISSOS •T5S Blood, plasaa »75€ Bio*. plan a 557 e loo.l, • note 758 Ovarr 81 POSHES 10 Inlectlon njection lection alllTTICal HIT BOD Radiosetrr Xnvsatic Bnzynatie ladlonetrv ilonetry BDHBEB \| BtUSI I HS»I I CIIIEIL IlfOBHlTIOJ t BZfJfBESCB or cisis i f i i lit i 1 II I 1 a) lot 9iven I a) 29S pg/»l I a) Controls, supine I lake. C.E. 1 b) lot given 1 b) 48 pg/l I b) Controls, standing ( Hikkeisec, J.J. 1 c) lot given 1 c) 232 ft/ml I c) Tnuretics, seplne I Bapoport, J.I. 1 fl) lot given 1 3\| S15 pg/ll \| 4) Entireties, standing I Zavadil, 1. P. 1 el lot given 1 e) 293 pg/al I «l Rmretie. supine, ox 75 g/lr 1 Kopin, I.J. 1 f) lot given 1 f) 667 pg/»l \| iiipraiine at nedtiae I 1979 \| \| j f) Snare tics, standing, on 75 ig/diy 1 Clinical Phamcologv \| f \| isinraaine at bedtiae \| and Therap«atics III 1 26(5) : 697-653 1 \| \| t nacetic tors, em me 9.8 » or - 1 1 it 1.9 yr. 16 controls, nean age 9,7 1 1 \| \| or - 2.* yr. 1 III 1 1 \| f unties: csiiDBM: BLOOD PBESSTTPB; i \| \| \| HCO0 PLI5IH; OFffS TBIS1PT \| 1. 1 1 .... 1 III 1 S \| »J >t gi»«a t a) 0. 19 or - 0.07 \| a) Prelose \| Htzo«rald. 6. 1. I b) lot given I uoVl I t) 0.01 og/q/«it I Rossunn. T. I c\| »ot giTea I b\| 0.239 ot - 0.1 I c\| 0.92 vj/kq/min \| Ha«llto«, C.I. \| 4\| Hat glrett I aa/l t J' 8-3 »«/9/»i« 1 Beld. J.I. t «) lot glTan \| c» 0.212 * « - O.OS \| «J 0.05 nq/kg/vin I Diti«s. D.S. I f) »ot gl»e« I »g/M 1 » 0.075 ugykg sin \| Dollery, c.t. 1 I 1) 0.219 » or - 0.08 \| 10 sin Infusion rates I 1979 t I ng/1 1 1 Clinical Flianacologj I f e) O.SJS » or - 0.09 1 BcalthT Caacaslaos. ages 32. » or - 1 and Therapeutics I \| ng/1 \| 1.9 yr, nonssokers, no caffeinated I 26 (6) :669-675 I \| q 1.34 * or - 0.4 j drinks For «S hr ( 1 1 ag/1 1 t j \| j Incrcaseil blood nnssare and reJaced I j j j heart rate correlated vita dose \| III 1 i i i rsaes: BLOOD ptisii: BIOOD VKSSSDB:; i \| \| ) "ITT) 1CHG3CB: 10BLTS I 1 1 1 1 III 1 ) 5 I a) lot given \| a) 2.8 nCi/g I a) lea-pregnant, peak. 1 iln after 1 Saarlkoslcl, 5. 1 12 \| VI tot given \| b) 1.65 nCi/g I deae I 1980 \| c} Tot jiT«n I c) 0.27 ncl/g j fc) Pcexnant, peak, 1 mi« after dose I tseriean Journal of I d) (ot gien I 3) 0.20 nCi/g I c) lon-pregnant. 5 sin after dose I obstetrics and I e) Jot give \| e) 0.05 oci/g I i} Pcegnant, 5 aia after lose I Grneealogr I f) lot given I f) O.OS nci/q \| e) Son-pregnant, 20 lin alter lose I 136(8) : 101-104 I \| \|f) Precrnant, 29 nin after dose 1 j i \| Zctinated frcn graph. Dose. 50 net I I \| \| (1.1 ngl in-labelled 3r«q, IT I 111 1 I \ i Patients nospltalizel for 1 1 \| \| sterilization or abortion. Dean »t, r I \| \| 63, 2-65.2 kg. I III t I i \| CFVGS; acc»iircT: BIOOO; rin»»; t I i i IITMDS: nni: OTHBIBS; OTIDOCT: t 1 i i ccHPiimn tritattiois f i i i i III 1 * I a) lot given 1 a( 0. 7 » or - 0. 1 (a) (os-pregnant t Saarlkoskl, S. * \| b) lot givtn \| nCi/g \| b) Pregnant \| 19RO I t b\| 0.3 « or - 0.1 j ? a in after 50 uct (1.1 ug\| I HmecictD Joarosl of 1 1 nCi/g \| 13-linelled dng, TT 1 Obstetrics and III 1 Gvneeologv \| \| \| Patient* nosFitalitel for I 136(8) : 101-10* I \| \| aterlltiatton or abortion. Ke» vt, \| I \| \| €J.2-«5.2 kg. I III 1 1 i i DSUGS; pifeiiKT; BIOOO: riKimi); i \| \| \| !TEJ ------- e«»rl alcohol, alpha-(asisosetkTl)-3,4-Uhy4rozr-. ft- ( CXI 1.2-geuenedlol, 4-(2-aBlno-1-hrdroxTethrll-, ffl- ft CI\| C8-H11-1-03 B« 169.18. BV 191 c (decosB) IlSSt)! 4759 OTidnct 4760 Vrlii* 4761 otens KiMsnB loot* XBjectlon TaJectioB lajectloa nitmcu BCTflOB ladioMtrr xadiOMtry ladioaetrr man or cases a) 5 b) 2 10 ») 5 b) 12 CHOC a) 3.5-2.2 BCl/g b) 1.1-0.6 «Ci/g a) lot given b) lot given •1 1.4-1.2 nCl/fl b) 0.8-0.5 DCi/g a»> al lot given b! lot glm at 39.3 » oc - 1.3t of 4o» b) »3.1 » or - «.OK of flow •1 lot given b) lot glrao GEI1U1 HTO1BITI01 •1 Im-pccgnuit b) Praqaant 8H9* of Mat. S «»d 30 li> after 50 nCi (1.1 nq) U-Ubellei drwj. IT Tatieats fcospitiliiea for «t«ttliTitica oc abortion. Baan »t. C3.2-«f.2 ka. muss: TIIGIIKT; BIOOD; Fimio: OISI03; Htlll: OTUIE5J OTIDOCT; ccflPMtiirt rfiiuitiois «1 loa-preqmaat b) rreqwit 2«-hr axeretion. ftec 50 »C1 (1.1 aa) H3-lbell«a dnj. IT Patients bospitalixel for atarllliattoa at abortion. Ben t. 63.2-«5.2 kg. ones; «Bfci»icT: Biooti: THHHD; ntlBus: 08iit: OT»IES; OTICWTT; CC8P1BITITB BTILOmoiS a) loa-preqnant t) Preqiant lange of Mans. 5 ana 30 ai> after SO aCi (1.1 aa] B3- labelled drna, IT fatlents kotpitalizea for •terilixatien or abortion, lean «t. 6J.2-«5. 2 da. tVKSSl tE6IMCT; BLOOD; nitWD; BTtBUSi UBIll; OTUIES; OTIDBCT; CCgPHkTITT mLIKIOlS BEFB ESICE saarikoski. S. 19BO laerlcan Joarnal of Obstetrics and Grnecologjr 136(8) :101-10»» saarikoski, S. 1980 taeclcan Jonrnal of obstetrics and Grnecologf 13« (8) : 101-10«» saarikosU, S. 1980 » aerie an Journal of Obstetrics and GTaecoloay 136 (»)t 101-1044 LO beti-^aittcocrraioiidaroaic acid, CTanoptenTleethrl. (E)- 1332-94-1 C1«-«15-1-07 «« 309.77, tir 214-216 C TISSO? 4762 Blood. 4763 Trine SIPOSOBE BOOTE Ingest ion Injection iBgestlon iBlectloB 1IILTTIC1L RETROD OC/HS SC/IIS ROBBZB OF CISIS 1 - 1 BUGS 180-60 ng/sl •ot given Bill Vot given - IS sg/al CtllllL IITOBHTIOI teak at 1.25 hr aafl 7.75 ir, after (.0 g til. Cancer patient. CEIGS; TTOPIISRS: BLOOD PllSBl! 2.25 >r after 6.0 g 11. 717 of doae recovered in 24 kr. Cancer pitient. DIIIGSl 1K>PUSS: BLOOD FLlSBl; Will. CBEPOTHEB1PT ntzvttct lines, fl.H. Kovach, J.S. flora, K.P. 1973 Research Cononicatlons in Cheaieai Satloloqy 22(1):75-1»5OSJ lees, fl.B, Kovach. J.S. riora, J.r. 197 Research Coananicatioaa in Chemical Pathology and Pharnacologr 22(1): 175-1 85 ------- Bctanwnlde, »-(3-ecetrl-»- fZ-hydro»T-3-1 (1-MthTlethTl> aaiao) neoDoxy) pheaTl) -, (»-(- 37517-30-9 CH-B28-I2-O* II J3«.«3, ft 119-123 C TISS3S •7«» Blood, plasna «7«5 Orlaw ntOSOIS BOOT! Infection Injection IIUTTICIL BXTBOD •rac - HPLC •tfSBSB or CISBS 5 - 5 BUM 13C-»C2 oj/1 a> lot oiF«B b) lot giro c) lot give* It lot given Bill 2700 » or - 1323 «g/l a) 30.3 » or - «.«S of dOM b) 30.8 * or - .5F of dose c) 1».9 » or - 3.3 of dose 1) tT.e * oc - I.Of of Sow 6i»tu urosHinoi teaks, after 0.35 «gA?. IT B«lthr 29-«« rr olaa, wt 65-82 k7. fasted before lose. D10CS: «»TIHtPMTEISITI 1SKJTS: loons; FIIIC:; iioot pusm; usiiri; BITHOIITIS a} VncbaBge& drea, 0-2K br excratioa t) VBChanqeit dr«9, 0-T2 br excretion c) «-«cetTl «et«l>olit«, 0-2 hr ezcretloe d) l-acetrl Mtabolite. 0-72 hr eiccetton rose, 0.35 ca/ki, IT. MaltliT 2»-«« TC oils, wt 65-82 k« fasted before dose. ciues : jtmnnBTMSiri »GB»TS: tBoiTS: rtticB; BLOOD ntsui nni:; XtltBOHTIS I BIIB»EfCS Bom. 1. Floant, B. Cbaa, B.P. letic, s. Lnesko, I. t»S9 British Journal ot Clinical Fhan«colo4T 9s2tS-217 Boar, t. noerat, B. Chan, «.P. tetae, B. lacsko, fl. 19»0" British Jonrnal of Cll&lcal pharmacology «t 215-217 latiroaln 12T7J-JS-S met coaposittot oinoii OB CIDITEISIIID U) ^j o TISS9C «7C< Blood, pinna Ttiae IIPOSMS BOUT Injection Injection IH1TTICJI BITBOD Bicrobloloeical •DBI2X or CISBS 6 6 mes a) 32-5 ng/al b) 20-2 ng/nl c) »ot glvei d) tot given «ft-123« of dose/2» hr mi a) (ot given b) lot given c\| 9.6 ag/tl d) 16.3 ug/al •At of d«e/2a hr GEIflat I«OSSITIOI •) 1 anl 8 be after slnale IB dose, 12 ng/tg, peak at 1 hr b) 1 and 8 kr after single IB dose, 8 •9/k peak at 1 be c) lean peak. Jar 1, dose, 300-900 » lean peak, day 2-7, dose, 300-90C (a tints, aoes 5S-82 yr. t 92-190 11. transient dirtiness Ilavated liver ensyies > CHITS: ntficTioi: BLOOD; BLOOD eiisBi; UBIWB; HHBIOHCS Base, ISO-900 ng/day. F«tle«ts, ages 59-82 vr. t 92-190 Ib. Transient dizziness Ilevated liver enxyaes ItSITS: IirrlCTTOB; BIOOD; 1IOO9 Piism: win: IITIBIOTICS Birnncc Keener, B.E. Coodler. i.l. 1975 Journal of Clinical Pnaraa oology 15{1»):«9S-S99 Keener, B.E. Coodley, C.L. 197S Journal of Clinical Pnaraacologr 1S(TO) 8«95-S99 ------- en 1«-Pvria«-2.6-dioM, 3.7-dlh}aro-1,3.7-triMtlTl- (9 CI) SB—0-1 C8-B11MM-O2 81 191.19, HP 23B C TUJIl «7«« Blood »769 Blood. alaaaa • 770 B1004. plasaa »T?1 Bleo4v Sana »772 Cerebrosp iaal fla.14 ciposm icon laoMtioTi Xalactioa Insertion iBleetioB alUTRCIL BII7JOD nc BPIC mjc mm or CISBS 1 , a 2 , MM lot applicable 6. %- 12. 6 a 9/1 •j 0.00-0. 18 na/al b] 5.90-10.93 os/al c) 5.99-8.95 ag/Bl d) 6.97-7.60 a«/«l a) 6.BO-7.10 ag/al ft 3.92-7.04 eo./al q) 2.80-5.97 a«/al h) 2.0S-l.ao ij/al 1) I.D7-I.19 tKI/Bl a) lot giea b) lot glues 6.5-13.3 •«/! Bill 1B.1 ig/100 Bl e.9 .,/j _ a) fl.08 » or - 0.05 ag/Bl b) 7.75 » or - 1.12 B9/BL c) 7.86 or - 0.65 aq/al. d) T.M * or - O.la a^/al •) S.82 * or - 0.15 •7/al fl 5.70 * or - 0.69 Ba/Bl ql ». 53 * oc - 0.69 Uq/Bl 111 3. 1« » or - O.S6 aq/al i) 0.«S * or - 0.63 ai/al (S.B.) a) 9.16 * or - 2.aa •9/1 b> 1.3* * or - 1.71. •9/1 8. SB aq/1 eiimi nvoiMtxor UtopST. Sasttic contents caatalaad 11 4 of drnq 19 jc old cues; camm: ILOOB: aowpsns; tTBS 1BH3I Saaav of aaaas, after 7-16 day* OB aalBteBancv do^e of 2. 5 Bo/lco/day. Plaaaa aad CSP caffelae correlated. c-0.92, KO.OOt. Ipaelc pceaatvre Ufaata, gestatloaal ade* 25-32 «k. poctaatal ages 3-96 dayt. citiim: nines: CIMDI: BLOOD fiiSHi; CBSiitosprni THJIB: IBTUTS •I It tlae ot dose b) If ME 0.5 ac c) after 1 hr d) If tec 1.5 hr el after 2 hr fl lft« 3 bt el after 5 kr a1 after 7. S ar 11 kfter 3« ar I«llovl« 300 a ------- caffeine (8 ci) 1l-»ici»e-2.<-diaae, 3.7-dihTilro-1,3.7-trl«thl- (9 CI) 58-08—2 C8-S10-1M-02 Of m.1«. BF 23» C (CORXIDXD) tissng «773 Carebras Iral/ren ricalar {laid «TT« 7rl« MPOSSSI ROM million. SZTBOB «PLC sue •ma:* OF CISIS 2 . •) » b) 11 0 3 « 2 •1 2 IMGZ •} tot given bl lot given •] (at glT«n b) ot giro e) lot give 4) nit lirtv e) fat gir«t mi i GEIEMI npoiuTio* 1 t l) 8. «2 « or - 2.42 \| •) Caffeine •4/1 \| b) Tfceopbrlliiw b) t. 00 » or - 1.54 t Steady state aftt eatfalva: 15 •4/1 I •«/« loaJlm doa«, 5 ig/kg/12 hr t Miateuiiee 1 Data also glv«D Cor th«opliTlli&e 1 See*. 1 1 Freiatm 5-» 4ai olds, 30 >k I gestational «•. birth «t 1,13t-1,6»« 1 9- 1 I iHKin; c»iFrr»t: TRaranLitcs; t BIOOD SIBVt; CEKIBIOSPItlt FIIID; 1 Hies ; OBB5 TBIB1PI 1 1 a) 17.5 mg/l fO.66) \| ) 0-1 «o b) 21. »5/l (0. f 2) t > t-2 »o d 15. » 19/1 (0.511) \| e) 2-3 mo t) 15.3 ag/1 (9,23) 1 a) 3- 10 e) 1.2 ag/1 (0.02) I «) T- «o I Values la pareataases ar« nlar I Ccaetloa ot elaaranca. Plaraa lervls 1 aatatalMd bctvaaa 5-20 ag/1. 1 ia»boci», aqad « daya-f ao, tcaatai 1 vita caffalna for apnaa or naar-alss 1 sudden Infant death. 1 I cross; gave tsniti-. ICTBOBS; 1 C»TFBI1?: VBXR: tDBTIBULItfS: i BltlDOlISB: H»SVRE»n IET8C9S; 1SI UFESnCE soaail. S.B. »tiaa»«, I.I. Bada, U.S. I960 Journal of Pediatrics 96 («)! 1091-1093 lldrldoe, I. traada, J. r. •ai», I.I. t«79 clinical Pbaraacologr aait Ikerapaatlc* 2S{«\| :«»7-S3 7MO-TJ-J C Itt (O.OB, BJ 850 C, SP 1««0 C, TV 10 la Hq at 1»3 C USSOK »775 nrloa 1 1 t 1 zxposim tovri Tafasttoii t IHLTTICsL I rarioD us HTBBSB OF CISIS 10 timt «) lot fir«a 6) lot gtrao BE* I 0.26 » or - 0.08 9/dar sfiiut ntrog«irro» a) Prenatal npplaaant «itk ieaa of 0.2«5 q/dar, total lltate of 1.37 a/dar. Data froa 2* T-d«r ciparlcaatal periods E) Dns«apl««atcd diet, total intake of 1.39 eVdaT. Data fro* 23 T-dar eiperlaegtal periods calTetsltT stndeats ad eaplOT««s. a n«ca« aad a teacher. Itlliparou, ages 19-2S JT. Ca nteitio* the «a« OK bolt diets. itmssn; unit; no: cucwi: iieizstgii: nil in is: »nospimi I.S. 1979 t«rtc<* Jounal of Cllateal latritioa 32:286-291 ------- caaahor (8 CI) ElCTelo(2.2.1)heptas-2-OM. 1,7,7-triaethTl- 19 CI) 76-22-2 C10-H1«-0 (« 132.23. at 179.75 C (corr., op«m capillary, 2 » diai), BP 20* C TISSUE •778 Blood. EXPQSVIV ROOTS Ingest ion IIILTTXCH SCTHOD GC RIBBEB OF CliSSS a) 1 b) 1 BUGS a) Rot glT«n b) lot give* Bill a) 1.95 ig/100 al bl 0.0015 ag/100 al GSIEB1L XITOBUTTOI a) 3 yr old 7 hr after 11.79 al Ticks Taporub (0.7 ga eaiptorl b) 2 yr old, 20 ala after U.79-29.tS il Caapho-Pheniqne (0.5-1.0 ga caaphoc) Bichigaa chiUrem hospitalized alter Ingesting toxic aaonnts of Bill rhlaortM, covgh, lov-giada ferer, confusion ««d irritability. eaatric apset and projectile voaiting fcllo«e4 by conTolaions. <1ICBX.SU; CISE HISTOSIIS; CBILDaill; ELOOD snail; DBBCS BE7EBSICC Phelan. B.J.. XXX 19T« Pediatrics 57(3):«28-»31 Carbaate acla, (2-(«»(2-hTdro»T-3-( t1-a«thylethyl)aaiiio) -, Mtkrl ester, (<•-)- C1«-B26-I2-0» Ra 278. M TISSUE -. •777 31004, plasaa EIMSHS1 »OOU lB«astioa IMlTTICll, HITHOD 8C-IC IMS!? or CISKS at « b\| 2 c\| » UIGB a) 12-251 ng/al b) J10-350 ng/al C) 616-850 iq/al HEll a) 19S.5 or - 51. » n 73.75 or- 91. « »9/»l GtltUL HTO5BITIOI a) Peaks, 0.5-1.S kc after SO ag b) Peaka. 1.5 kr after 100 ag c) teaks, 0.5-2.0 ar after 200 aq- BcalttT 18-29 Tt olds tSOSS; BLOOD PLaSn: IOOLTS; CCHPlUHITt ITltOlTIOIS sznmcE Carrrtlurs, S.G. Pentikainen. t. Coaler, J.P. RzarnofC, 0L. 1979 clinical Pharaicology and Therapeutics 26(S);«82-«65 u> cefotatiae do postinqs la CBMLIII). I 115301 1 1778 Blool. serve »77? Slool, sera a HXPOS1F! BOOTE Injeetioi In lection IIJITTICM, BE? HOD licrobielogietl Ucrobiological •tnBss or cisss a) 5 b) 5 c) 5 12 B1IGE a) 37.9-1.0 og/al b) 102.»-1.9 ng/al c) 21». 1-3.3 ng/al 9.1-1.9 ug/al Bill at 7.65 «g/al b) 17.5 ng/al O 33. S ag/al lot glren 6E1RII laTOBBtTICI - a) SOO a? 4c» b) 1000 ag lese c) 2000 aq dose ti»e-aTerag« Beans after S all IT. laak at 5 tic lata also far aultiple IT and 19 doses 22-33 Tf olda, wt 75-81 kg. UlIISIOTtCS; BLOOD S15BH; >BU1TS; U»ME! COilPlBlTITI! ZTaLOaTIOIS: BEOBS 1 aad 3 kr after 1 g Haige of leans 1 CHITS; BLOOD SEIDH: IILK; IITIBIOTICS; DKOGS; UCT1TIOI BETEtEECB (en, B.C. Asvapokee , P. ra, s.. Catthijisei, c. 1980 Clinical Iharaacologr and Therapeutics 27 (5): 677 -685 Kafetlis, r.«. Siafas, C.I. Geoigakoponloa, P. ». Papadatos, c.J. 1981 Jet* Paediatrica Scaa4inaTlca 70:285-268 (IBXT PAGE) ------- Cefotarla* (Bo porting* la CKUIH). (CORIIOBD) iissai »780 •ilk »7B1 drill* 1XHS1HE BOOT! Injection In lectio* IBUITICIL HIOTOD BicTODlolofleal Ricrobloloaical nun OF C1SSS 12 •t s bj S ct S BUSS 0.32-0.13 g/l » lot «.l«ei b) Vat gi»« c) lot ffi»i mi lot ;ien at 5»* of doee (295 ••») b) 52* of do** (520 Hi e\| M of dose (90 •0) GBBHiL iBroiunoB 2 and 6 kr after 1 «. Initial aeaaiTeient. 0.15 ag/l at 0.5 ir Baig of MIBS JCTJITS; B1OCD S»m ; BIIK; IKiBtovics; Dnss; ticiinoir •1 590 19 ioa« b) 1000 W) «o« e) 2000 •« Acs* 2« kr •xcrctioKS after S ill IT 22-33 TC oldi, «t 7S-»« k«. HUSIOIICS: BLOOD SUITS; JIDUIIS; DIII8; COSMMtlfB EVllflltlOtS: DBOGS 1 BRtmCE Kaf«txi«, 0.1. slafas, C.I. Georqaltopoolos, ?.i. Papaftatos, C.J. •Mtf »cta Pacdlatrlea $cuiinaica 70:2S5-283 >o. I.e. >«apot«. t. Ta. K.f. Bo. I. Battkijsn. C. 1960 Clitlcal Pbaraacologr and Th«rapeotics 2T(5):6T7-«iS Celcnlcine (9 CI\| leetaside, B-<5,«,7.9-ttnh]4ro-1>2,3>10-ttraMtfcoz7-9-on>baazo(a}heptalea-7-Tl]-. (S\|- (9 CIJ (•-86-9 C22-B2S-B-06 II 399.13, If 12-150 C ixssn IT>2 Blood, •«r»« nrosn: torn Ih4»stloa •• IHLTTIC1L BTSCB HI IOBBBI or cisjs > • t>) 2 o) 3 d> 1 Buei a) 1-2.5 g/al i) »-U Bj/»l c) 1.5-S.5 ag/il d) 9-13 ag/»l rej« ) Bot ji»«B b) Hot gir« cl lot giT»B d] lot gir«a eciiBii nroiBino a) 30-19 fit aftr 1 K doa* b) 11-210 ill) aft»r 2 (4 d«». rtsponlero e) »S-21» »li after 2 •? do«. B«»«SVOBd«ri d) 15-210 til after 3 ag dose. B0acespoik4«r nta also for IT Solas Catieats with faallial Hediterraaean f«»«r Diiss: isFiii; BIOOD snaa; iiismnnt IBTRODS; gisiisxs; slime BFFKTS: rare raisin BiniEICE Balkia, B. 9aaT. S. Cree»ald, 1. Shiaps, T. Tirosh. B. 1980 clinical pbaraacologr and Taerapeutlcs 2B(1):S2-«7 CO Cctinlae (B CI\| J-PTrroli ------- CdtimlM (8 CD J-FyrroliaiBCae,, 1-tethyl-5-(3-pyrldlayl-,, (S)- (* CI) •16-56-6 C10-B11-12-0 Bl 176.21, 210-211 C at 6 » Hg (COBTIIOZ91 «SS9« B78S »78S Brlae •716 Brine SIP03UK MRS IBhalatiOB lahalatloa IBhalatiOB IBIIRICIL HRBOD til BI1 oc BOMB or cists a a) 21 b) 30 58 MBGB a) l.t-a.] eg/24 hx b) I.S-S.a ag/2« hr a) Bot gltea b) 0-t Bg/dar lot gi»ea nil a) 3.0 + or - 1.0 b) 3.18 » or - 1.6« •9/2* he a) 0 b) Bot givea 106 * or - 13 (SB) sq/100 Bl GBIZ11L IBFOBB1TIOI a) » days OB 22.5 » or - 6.3% b) * days on 27.25 * or - 10.5 clq«ett«s/d7» -• ag Bicotlne each 20-30 TT old saokersi IB good health, aalatalalag noraal ao)tUg habits StOKITC; IICCTIBB; BIOOO 711SHI; lOBKCOS; CCBMBimi BTUOMIOBSi It SITS; EBBOCI.OBI1S; IUBE a) BoB-saokcn c) Saokers Bospital patieats vithoat renal or JtOntS; BICOTIMs BRtSOtltSS; J1CLB; ^lITtS BllSBSZRm BITBOSS; TCB1CC03 laadoi saaplcs. IB subgroup lth coBBtaat dally cigarette coBnaftion, a«Bber SBOked correlates strongly •1th cottaiaetcreatialne ratio Begalar saoker atteBdlaq Infarction clinic. O.K. iCfllTSt BX1BT DISC1SK; DBIBZ: CCBPIBITITZ miOlTlOBS; BE1SVHIBIBT BBTBODS; HCCnii; BBTIBOIITZS; SBORIIG ssrzUBCi Bill. ?. Bargaardt. B. 180 Cllalcil Elaraacology ani Therapeutics 27(5):«52-«5S Batsacara, S. Sakaaoto. 1. Selno. I. Taaada, I. 1979 Clinical Bhataacolog} and Therapeatics 25(5 lilcoi, B.O. Bvghee, 3. Xelasd, J. 1979 British Bedical Journal 2 (6197): 1026-1028 CCBBazlB. 3-(alpH-ac»toiiylb«iiyl)-a-l1Tdroiy- (8 CI) 2B-1-aaaxopyraB-2-«B«. a-ijaro»r-3- (J-oio-1-pk«Bylb«tyl) - 81-81-2 C1»-B16-O Bl 308.32, BB 161 C CI) IISSOl »787 Blood, plasaa xirosns MVtz iBjectloi iBgestioa iBiinicu. BZTBOD BftC - BOBBSK OF CISSS , -- t tarns a) B.7-0.2B ug/al b) 5.8-0.17 ag/al e) 0.76-1.99 ag/Bl a) O.S6-1.89 Bg/al - . -. a) Bot applicable b) Bot applicable e) 1.3S ag/al d) 1.11 aa/al - CBItBU. IfFOBHTIOB a) 0.25-100 hr after ao ag I?. Biexponential decline b) 0.25-100 he after ao aq It plas 2 I Ig/laf elofibrate, oral, starting 3 iik preceding larfario dose. BletpOBeatlal decline c) Steady state levels OB 5-10 ag narfarlB dally d) steady state lerela oa 5-10 aq •arfaria dally plat 2 I Iq/day clofibrate starting > 3 ks before varfarlo treataent c) lad d) different p < 0.05 Healthy 22-35 tr olds, no BBdicatloBS for 2 preeedlBg irk. ones; ciiifcwii; BLOOD nism; DRUG IEfSI»T: I30ITS; COB?1UTITE ZTIIUTIO'S; BIT1B011TSS; CB1OSIBB BZrSlEBCE Biornason, T.D. Neffla, P.J. Sez«y, S. Blaschke, T.7. 1979 Journal of Ph&raaeoloqy Bad 5iperli«ntal Therapeeties 210(31 :316-321 (Birr ------- Ccaanrlft, 3- (alpb.-a-eeton JHWHITD -1-hraroiT- 2B-1-Be»Toj>Tran-2-on«, -hT4»X7- cw-ms-oa 11 308.32, III 161 c (cortmreo) IISSB «78t Blood. riant •7«9 Blood, plasaa •7»0 Blood. plama »7«1 Blood, 5«m ZlfOSOSB BO Inoistliu Ingest lot tnqestion [eat lot IHtniCll HBTBOB Tluoroaetry t 1 0?°CtSSS ' "" ' MI1 ' eilHttl IITOS8»TIOS ( BWE8MCZ - - « ! ! ,' W ! M J!£V«"9/il, ' M S>1 •9/>1 ' "' M S(> «•"«<»« «•>»• 1 Una.!. l-B. t b) O-W-1.6 m/al \| b) O.W og/il \| t\ Dos« as Sf-» cMatlowr I O'lellly, I.». 1 c) 1.3-2.7 njy«l I c) 2.1 a«x.l \| c\| Dan M ricmlc lixtvr* \| l»»j, G. J I I I«»«ls at vklch tfco sritliesia rate of I 19"»8 ' 1 1 protbrosiln caspl** sctlrlty r««che3 \| clinical M»r»col<»97 J 1 1 59* of l>re-dos« rit«. »ft«r 1.5 \| and Then\|wotics • J 1 •«/»?• \| 2 J (2) .-212-217 < 1 1 Kiltkr 21-'1 yr olds. \| 'II \| 1 I I moss; »iiico»GOLi»tsj BLOOD rtmt; I I l i ccariBiTin miBiTiois: »BOITS i ....... 1. . . i t 1 1 . i i , « r aj «.8-2.5 ««/»l \| a) lot apflic.bl. \| a) Infarla, coatrol qcoqp I \| «l«so», C.». ! b? M"!w? 99/ml ' "' ot »PPlicaHl« I b) lactarU » 80 n/iar faroM»Ite \| Horton. B.S. 1 c) «.«-2.2 ng/«l » (:^ »ot applicable \| «) iarfarl«, control qcoap II \| Eobloaon, D.S. 1 d) 5.7-2.8 «4/«l \| j) Hot «pplic«bl« \| « lacfacla « 2 aq/Jar boMtantde \| 147» J 1 1 • "4 » be Man- after 50 »g {aring \| Jontul of Clinical ' 1 1 central period and oa Stb ij ot I Piariacologr 1 1 1 Mantle alaUlstratloaj. I 18 (2-3) :91-9« 1 t 1 1 1 1 1 lornl 18-2S jr olds, onUeraltT of 1 1 1 \| T«rio»t. \| 1 1 1 CtOSS; 9106 TIEMPT; TIBBOrT; SHUTS; 1 1 1 1 HCCD niSKl; OIIJ»IIICS; COHPUITTTI \| 1 I r f»»if»Tio»sj «rrico»CTi»»js i 1 1 1 1 1 (--. .,...!..- 1 1 ?' !i27S "9/>1 br ' •' 21T * « - 2« 1 a\| H-«acfart». 1.5 M/t5 \| o«»«lllr. ».». 1 b) 127-35* nj/al hr I »a/«l hr \| b) e->arfarla. l.s aVkiJ »0.23 g I 1981 ! ?i ?JTJ?? "9/,1 br ' b> 29 * or * 2» ' dis«lflra./aaT \| Cli.ieal Pbar.acologr 1 3) 39-117 ag/al ar \| «g/»l lr \| cl S-warfarln, 0.75 »»/1tg \| aad Tatrapeatics 1 1 el 70 » ec - 11 Bg/ail \| dl S-«acfaciD, fl.75 afl/kTFOPiot1iToatlacala \| 1 1 1 >c«a onl«r tba concantEatloa-tla* \| 1 1 I ctt»« data \| I 1 1 B«my 21-30 Tt olds t 1 ' 1 I 1 1 1 Bisnltlraa ao««at1 ' a\| 2'61 ot " °-35 1 «1 »tfot« lapcam. Mai of Jars 7-11 \| Jala. ». J i!2"l'J3 m9/'J ' l/"1 1 ll "«»4 •aprot«t, ma« of 4ar» I RcXahon, r.s. c} 2.3-3.S2 Bj/ail \| b) 2.»e * or - 0.»5 \| n-2i , sia.ttcj, J.'. 1 au/al \| c] »ft«t aaproien, am a of days 2«-2« I I«Tf. e. 1 c) 2.«0 » or - 0.»7 \| steadT-stat l«T«la (fn« * { 1979 t nu/al \| protein-brand) prior to daily dos< of I Clinical Pharaacologr 1 I llqnlficaat affact of Mproitn. \| 25(1): 6 1-66 t I ««althr 25-65 rr olds, »t 7».1-«8.5 \| 1 1 »9- \| 1 1 1 1 i cti8S: imcciGDiins; t 1 \| l\|TI-Tni«41TOBT ICIITS; 31COB \| t 1 snm: oni!; COIPUJUTE i 1 \| IT»m«TIO»3 \| _ ..i . ...,.- t ( \| ------- Cauarln, 3-(alpha-aeetonylbrazylJ-4-iirdroxi'-> sodian salt (8 at 2I-1-Se»opyra»-2-oae, t-hyaroxrO-O-oxo-l-phenylfcatrl)-. aollai salt (9 CI) 129-OS-S C19-DKr-Ot.il ill 331.34 nssn-g 4792 Blood. plasna 4793 Blood, plasaa 4794 Blool, plasaa tttOSmt BODIB Ingestioa inqestioii Ingest Ion imTTIClL »ST«0» •PIC colorlietry Colorlnetry ITJBBIS or cisss 9 _ .. ._ - 10 1 BUGS a) 0.25-0. 51 •g'/l b) 0.16-8.61 »g/l _ a) 15-2 m/el b) 15-0.3 wj/sl c) 14-0.9 ng/el 8-0.9 oq/el mi 6!»mi irrosBiTiot ) 0.40 nq/1 a) Snokers, after 0.032 if/kg, 1H b) 0.45 ng/1 I dose, 2 » I t) Sablects and dose as In a) , after 1 1 no abstention fron sacking j Steady state levels. Means 1 elaniflcaatly different. i 1 Bealthy 19-60 yr olds, sacked at I least 1 pack of ciqarettva/day. 1 I Itticoaqnlant effects (lengthened 1 protnroebln tines) . 1 1 IBISS: SROKITC: TOBICCOS; BIOOD \| S11S1M COSe»BMIT« ITliniTIOIlS; 1 imcoasntaiis: RnisoLisi: MIYMSS-. \ TPIOCTUl^IS: iDOlTS 1 a) lot applicable \| a) 0 and 1«9 he after 1.5 ag/kg of b) lot applicable 1 S\|-> evantioaorpn e) lot applicable \| t) 0 and 168 he after 1.5 ng/kg of \| t \+) evantlcaorph \| c) 0 ud 168 hr after 1.5 lo/ki) of 1 «,S(»,-) raccnte \| locaal 21-51 yr olds 1 Crothrovtln tine >as highest 48-72 hr 1 fcllovlnii adilnlitratlon. S(-) forn j above] greatest effect in increasing 1 prothroebtn tine and In decreasing \| ccothrom&in activity. 1 I itiirs: Btooc piisBj; saves t I lot giren I 24 and 144 hr after 1.5 »Vk?> j tatinated free graph. j Spiroitolactone, 200 nq/day, 7 flays. 1 had no significant effect on 1 axea-ander-tle-cnrfe of (arfarln. j lata also for other sablects. j Healthy snblect. no other drug foe 2 I ao. 1 I Increased prothronbln tiles. Effect j aiiinlshed by splronolactone-liduced I aiotesii. I CSOGS: 1BDG IKTmCTIOR; \| 1ITIC01CH1KTS; BLOOD °L15H1: \| BIOFFTICSj IC01.TS: CC«P»t»TITt . ,. 1- ....... ... . BzreiEicz Bachnann, K. Shapiro, 8. Fulton, B. Carroll, r.T. SalliTan. T.J. 1979 Clinical PhamacologT and Therapeutics 25 C3f. 309-3 IS O'Beilly. 1.1. 1974 cllaical Pharnacology and Therapeutics 16 (2) : 348-354 0'P.eilly, S.». 1980 Clinical Fbarnacology and Therapeutics 2712)5198-201 (IEIT PtSE) ------- Ce»MTt», J-f»lpk«-»c«tonTl!>e««rU-«-lLTdla salt (« CI) 39-t-ae»opruB-2-oae. •-lrdrffir-3-fS-oio-'-PliejyllMjll-. xodloa salt (9 CI) 129-W-* C1«-816-oa.ia 1« 331.3* (COITflDED) 1ISSDS »lt>oj. plasaa srrosvn ROHM • MLTTTCH. HWHOD Of C1SE5 9 8MU a) 3*-5.2 tag/si b] 1.03-1.81 aj/ed c) 1.C2-2.5C a9/l a) 0.88-1.22 og/.l e] 0.79-1.25 »g/Bl mi i amtu iiromnoi 1 l ii\| 1.275 oayil I »«/a»T c) 2.158 «g/il 1 b] 5 eautloeec, » patients, t. S-10 A) 1. 108 ag/al I tj/4»T •) 0.978 ag/al 1 c) laeeaiie (arfacia. ( patleatx. 1 5.5-12 ag/atr 1 leyda? \| e) s eaa.e timer, • Taluteers, 5 f Steady state lerels i 1 coinlettiq inticoaqalant taerapf for 1 leep vet ttieabofls. lo other I «Slcvtloss. laer 28-70 71. 1 1 Doses fot qood aaticwaalait coatrol 1 qceater Cor t warfarin tbaa far 5 1 vwfarla {• < 0.005). 1 I noes: iiriccicDHns: BIOOB nisai: l tismiss nisi ersuses; centntstn - ^ BUEIHCI Sreckeirid < 1 OCM, 8. Le«is. S.J. «ibbcMs, I. 197^ Clinical Pharaacology and Thecapeetics tS()i«2a-«o B,.lphi-4ia«thTl- (S CI) I.tlpla-diistkyl- (« ci\| CW-K1-S n t^.2«, B» WS c at Ttg • 85, c at 20 •• :« (11 foci) u> -J 00 flJSOI «7»« Bile RJTFOSW BOOT Inject IOB imirncu JOSBSI UTTBOD OF CISS5 ec a) i b) 1 jiiss i mi a) lot applicable 1 a) 0.44 ag/dl b) (ot applicable I bl 0.57 eg/dl 1 GJIJHI nroiimo* a) CY«rdos« death b) Delta 1>i haaqUe It- 23 TT old blacks, histories of ------- CTClokexaaeethvlailae, f.alpha-diaethrl- f« CI) CvelolexaDeetaiiiaaliie, I.alpha-diaettTl- (9 CI] 101-W-* CW-MI-I » 155.28, SP 205 C tt 760 •• Vg. 92-93 C at 20 •• B« ------- ycoeianeeT' ». alpta-diMt ayl- (» CI\| Cjclol>e»aj>eeth»«aai««, ».alpto-4i»etaTl- (9 CI) 101-M-S B» 155. It, B? 205 C at 760 » Ha, 92-93 C at 20 •• 89 \|dl Con) tISSfl! •tot 3ria* 1 HB01 Tltreoaa 1 humor 1 1 1 1 1 1 1 I f 1 TMfosmt BODM t imnmt f HBTBOB 1 t !»-)ection To -faction ac ec XTRBSS o? cu:s i •) 3 B) 1 tins'! tot applicable a) 0.05-9.22 aq/dl b) tot applicable WM 1 GBinii irroMitios 1 i 1 .95 ag/41 \| cterdose death 1 1 14 TT old black, history of 4m« 1 aktise. I 1 Basslve deaeeasatloa of alveolar 1 lialnq cells, focal litre-alveolar 1 lesorrhaoe, ad ante passive 1 congestion. Increased Anabcx of f aononaclear cells IE aortal «re» of 1 liver. 1 j c»oes: siii: Btooo; nnns: Lira; l mm TiTPFons sanof; stae JBUSI; 1 C1SI ItrSTOBItS; CORFHlTIfE I min-novsi THIS i \ — - a\| 0.12 ag/dl I a) Orertose deatas b) 0.05 a?/dl t t) Death tf tai^iag 1 1 11-27 vr old blacks, histories of 1 9tog abuse. f 1 BypeYaetlvltv. vsconffcioasness death 1 1 caresehTsa coafested. eoBsist»Bev of 1 rotfcec. severe aedical hrpertropiir 1 aad iatisa kfperplasla of the saall 1 aoscalar arteries of the lanqs. 1 llveolar septa Utekaiied, aecoadarr 1 to diffuse f Ibrosis and acote passive 1 cetaestioa. 1 BMSS; BIlBs BI.OOD: KHKEIS; UT»B; I otri: VITJICOS BBHOS; !>rs tsist; f cisi nsnntst cmtntmis 1 tTHtOlTIOHS: TK1S 1 VI'BKSHCS DiKlio. T.J.B. Harriott, J.c. Joaraal of forensic Science* 22ni:«2-1Si Bilalo, T.J.I. earriatt. J.c. 1977 Joarnal of Forensic Sciences 22(1) :IS2-15B OJ 00 o oiane, 2,2.»,S.,8-lieMaetaTl-t.8-dlplienrl-, cia- HI «2». BJ TtSSUS Blool, »«i»a riPostrM BOOTB Icjastion iHilTtlCH 5BTHOD as or cisw T »MO! 1.1-5.0 ag/1 SSI I 3.5 mg/1 eiHUl HJO^llTlOl teaks, -8 hr after 102 ag. slagle Jose. Sleiieseatlal decline. 4ea ettfc nrostatle carciaoaa aad • etasti«es (toae, liver) . fieneral lipraveseat, relief ef pain ft 100 iq 3I/dav. la aUe effects. B»&eS: 9R"S mmpT; CBEHOTWIUPT; >EOn»15; SIX; 1DOITJ; 5>tDI>; B10OD STJOf (EltSXBCE T libra at. 1. Striadberg. B. let a PaaraacDlojiea et Tosicolojlca 36(S«ppl lit} 1 139-17 ------- D-streptaelie, 37517-28-5 B» 585. 92, BP 203-204 C fsesguihrlntel TISSH 4803 aloe. sens BIPOSMB ROUTI Injectloa IfUTTICll 1BTHOD BadloaetrT IniyaatLc meat OF C1SSS t HIGH •) lot applicable bj lot applicable JEII a) 21.5 ag/mi b) 18.3. us/ml __ . GKIIHl MTOSIMIOI •} teak. 1 Ir after 30 «i» IT of 5 ng/g t} Teak, 1 be after «» aim It of 5 s«/g Total of IS ig/kg/2* »r diTided la 3 loses. 53 TC old leoteai* patient lit* noraal renal fa net Ion. csnes: BSUG TBisi?!-. miBioncs; CHiiO'SE't: THIS; nonaSRS; HOOD SIBBS SBrSKBCS Fraaer, I.G. Clearr, T. Fraakel, I.S. Kohl, S. Pickering, t.r. I"1? Cli«ical Phactacologr &nd Therapeatics 26 (5]: 635-640 D-Strvptaaine, C18-B3«-I»-011 n •i«.S8 TISSdl »80» BlOOi, sera 1IPOSTO? EOOfB Inlectlon ammcil HETHOD aicrobiological BOBBIE OT CISSS 16 EtIGI 15. 1-20. » ng/»l b] 0.7-2.6 aq/al c) 15.0-22.* «9/«l d) 0.9-1.8 i?/al n» al 17.1 ng/al b) l.a ocj/al c) 17.4 ng/il d) l.a ag/al C'lISll I»TOBBSIIO« \| ! a) IB, peaks. Peak tUe 1 hr t) IB, tcovqks at 8 hr el 20 ain TV. peaks. Peak tiae 30 il« 4) 20 ait IT, tr»«(jha, at 8 lr 10 aqAg/8 hr for 2* dr. 1-1S fr olds, Texas HTlatQTICS; BLOOD SIB 11; CBHDSU; tltJS: COXFaMTIR TTSI1HTIOIS; nmm; imciion; STIRGBET BEFESEJCE Tile bar, J.t. fassiesz, H. «elso«, J.D. 1980 Joacaal of "ejiatrlcs ««(<): 1981-1 091 CO Dlbeii«(b,e)oxepla-aelta(11{6in,gaHa)-propTlaalae. 1-?ropaBaaiie, 3-Albat (b,«) oiepln-H («B\|-rliaene-I,B-llaetkyl-. hjiSrochloclde 1S2»-2?-» CW-B21-1-O.C1-E B1 If. 91, ft IBa-185 c, 189-189 C 8 cl) CT) tissm (80S Blool, plana IIPOS8SE lOtTTE \| 1 Xngestlon UllTTIClt HETBOD oc/ir "OHBIS or CISES 1 mot Sot applicable 8EII 1 1 2123 >a/»l GTimt moiaanoi Gaak. Data for aixed doKepia-RCl and aaitrlptTliae-HCl oTerdose also available. Ciecdose patient, a?« 23 Tr. QS; o? 100 asec or ateater en roatine •C5, »nl one or nore of tie folltnicq atnoraal Setf tendon r«flei«s. ventriolar rate of 120 beatc/nin or greater, riqht handle tranch block. atrial and ventrlcalar preaatare ccatractlona, lanctional and idioventlicalar arrhTthalas, ttaconsclansness, respiratory support >«cessacT, ocaad «il seizures, and acath. IOVGS; HKTIt'PfESSITE 1CEHTS; BW03 ftisii: IFQG masi: IISSODBI SEFEKFCB Erlggs, J.T. Spilt er, D.G. Petit, J.«. Zieglec, T.E. W77 Animal of the aaerican Kedlcal association 238\|2)s135-13S ------- tlqitosll (» Ct) Card- JO fI2) -enolide, 3- ( (0-2,6-aideoxy-lieta-B-ribo-kejtopyeaiiosyl- (1-»)-O-2, 6-dideoT-»«ta-D-ribo-a«,ropyranosil- (1-« ) -2,6-aideojT-beta-D-rlbo-heiOBTraaosrl) OIT) -1«-hT4roxr-. <3bta.5beta)- (9 Ct> HI 76S.92, HP 256-257 C (anhydrons) TTSSJS MO* nooi. pla»a ixeosms ROUTE Ingest Ion tutrrrcai BEIHOD RU BtUBXB OF C1SSS 21 EJICE 9.5-1S» »al/l MUI _ fot applicable GEVEB1I, IIFOSUHOI . ICter aaititenaice doss or ussiie overdo 98 Cardiac patients and siBjects ritJt digltaiin peiBoninq. »8»»C«; IDIIITS: C»8»TOTISC9HB tlSMS^S; &1000: BLOOD P1ISB1; DRUG TBII1JT; C08MB1HTI STSL01ITO1S; I» tITBO triITSIS EIFtBESCE Scherciann, J.B. Boarloc, B. 1980 Clinical Chttcistrr 26:670-671 Ciqoxla (8 CT) Cr4-20(2?l-eni>lll«, J-((O-Z,«-M4eoy-b«la-B-ril»-»e»opjraiiosjl-{1-a) -o-2 (« CI) ITI 780.12, IIP about JS5 C (4ecoip> IISSB! • 807 Unlotic flnl4 «898 Bile «609 Slool, fetal EIPOSU5E ROOT iBlectioa Tn-Jecttoa n1«ctlo« ililTTICIL RETBOD Btl CC s«4lo«etry BT1 »n»BSi OF C1SES 5 a) t » 1 a] 3 b) 12 BUSS lot detectibla -1.5 nq/il a\| fat applicable b) Wot applicable a> 0.85 - 3.99 ng/«l b) 0.20-1.10 nq/il BE»P \| client urosaiTioi t 1 1 lot applicable I at Selirair, after 0.2 >q IT. \| 1 Italians ql«n digital Is dnrlig 1 Tceqnaicf. \| I EIOGS: ITlIt; PEEGS1ICT; BLOCS SEBDR: I imOTIC TIHW. 01BIIICH. COED; TC1ST 1 tisHSfs; DBoe TUJPIPT i - l a\| f. l« of dose I 9> « of In -tec ted radioacti-ritr in 50 b) 10. 7< of dose I il after 38 hr. nose, 150 aci 1 31-digoiin-12alph«. >90"= «as J ai90* «M dlqciin. 1 1 Tatieats vith aeate reoal failure, on 1 faintenance doses. C 1 cities; ORoe TBXE1PT: nrriBoiiT^s; 1 DBI«»; Bill; C»I»D1; CO>IP»B»TIT- 1 I»JHO»TI01iS; BISB1SSS; SST»BOI,ISI» 1 a) 1.SS * or - 0.35 1 a) < 1 kc after dose. Tallies lower (SE) ao;/il f tian latenal serai, ? < 0.001 b) 0.55 * or - 0.08 \| b\| 74-690 tit after lose (S«) nq/«l I Cord bloal at dellrerr. after 4.2 kg 1 IT to withers. t 1 Ttaliaas qiT«n digitalis iSncinq ( vreoaaacr. 1 1 cmes; iTitT; PPEGVUCT; Btoco siaon; 1 lesioiic riuio: OHBIUCAI COED; RSIAT 1 tlSFlS^S; DFTO TSEtlCT 1 IinSESC! Podeletti, 1. Porciani, H.c. Sciaooe, G. 1979 International Journal of Clinical Pltarfeaeologr and Bioj>har«acT t7 (2): 32-83 Caolt, n.R. Sagdan, D. Haloaey, C. Ihwd, a. Twee Wale. s. 1979 Clinical Phariacolo9T and Therapeutics 25 [S pt 1):»99-513 • Padeletti, L. Porciani, I.e. Sciaoae, G. 197« Internatiotial Joarnal of Clinical Pharmacology and BiopliarMcr 17 (2\| :82-83 (HIST PUSH 00 ------- Clvoxin (B CD Cira-20(22)-«olide, 3-( (3k«t,5beti,121>ta)- f9 CI) 20830-75-5 -D-clbO"-heiopyranosyl)oi7)-12,1t-dihrar<»r-» •I 180.92, U a boat 265 C (ieco«p) 1IS3VS «10 ood. plasca • 811 lass. »812 Blool, vlasaa • 913 Blood, sens BTJOS01B BOTH lection nvestian ftgestloa Injection Injection IBUTTICat HETHOD Ell laataoassay m. Rla TO BOSI 0? C1SZS 3 ) 21 b) 11 5 11ISE J.3-7.5 naoles/1 6.3-13.9 naoles/1 0.7-5.1 nnoles/1 7.2-18.8 iaolas/1 ] 0.38-1.20 naol/1 b) 5.24-22.C6 nnol/1 a] 3-0.3 «a/nl b) 16-0.42 g/nl 3.18-10.67 ng/nl mi i etiisit itroiuTioi 1 i 1 %.* naol«s/l t a) teaks, n.5-75 nin after 50 sg 10.5 moles/1 \| (oral), joanger patients 2.6 »aoles/l \| t) Peaa. 15 nin after SO »g IT, 11. naoles/1 I TC«q«r patients 1 c) Beats, 1-a hr after 25 nq (oral). I tlderlT patents I a) Peaks, 13 nin after 25 ng IT, 1 elaerlT patients 1 I 6 tenales, aoea 31-61 yr, and a group \| of ! feesles and 2 sales, a-ees 72-91 I jr. til rlth eecdiomegalT aid on I ctfcer nedications. 1 1 ewes: tett BETJBOIISH; BLOOD ;usi»: \| 111VT DISMSIS i 1 1 Int applicable \| a) Talue* by Ell. tercemt of b) lot applicable t cto«s-r«icti»ity to dlgltaiin 1 ) Initial •easaranttnt snS 76 hr b) lot girei 1 alter 15 og/g IT bolus I t) initial seasarment and 80 nr t after 10 eg/kg IT boles and after 8 I lays on 200 J aainUlne. 2t/day I T«tlBate9 fro* graph I 1 IKaltay 21-26 yr olds. 1 t fosltive inotroplc effect of diooxln. 1 ainUished bT gnlnldine. 1 1 DIOGS: nipimit: noon PUSH; MOLTS; 1 KOCB >KTSSmt: VtIS UTEBJCTIOS 1 8.2* ng/nl 1 Calculated 0 hr (peak! ralaes 1 adlastel to b«laa IT lose after > nin 1 11 of e.8-«.« ag/kg. Biextonential 1 dfdlaa. 1 I 3^-76 yr old patieata, serere renal 1 iapairnent, congestive heart failare. 1 \| CH1G5: 1)806 TWE19T; BIOOD SESOII; \| 1ITH.TS; DISUSES t lErErarct Cusack, 3. Kelly. J- 3Halley, K. loel, J. ^aTftn, J. Horgan, J. 1979 Clinical Pharaacologr and Therapentics 25 (6): 772-776 Schvrrnau, I. B. Bcnrdon, B. 1939 Clinical Cheaistry 36J619-671 stelness, I. laUorff. S. Bansen, P. 8. Klaergard, B. tack, S. Eqebla.d, B» 1984 clinical Vharaacology and Therapeutics 27 [61 s7^1— 79S Koap, J.S. Jasko, i.J. fl.ool, C.B. Kaali, 9.1. 197? Cllaical ?baraac ------- ligoxin (8 CD Card-20(22)-enoli4e, 3-{(O-2,«-diaeojtj-beta-D-ribo-hexopyranosyl- (1-«)-O-2,«-dideoxy-beta-D-ribo-l«>xo{>yranosyl- (1-» Ubeta,5bet>,12beta)- (9 CI) 20830-75-5 C41-H6 4-014 as 780.92, BP about 265 c (deconp) (COKTIKHED) -2,6-dideoxy-beta-D-ribo-heilopyranosyl)oxy)- 12,14-dlhydroxy-, TISSUE 181 Blood , serai 4815 Blooi, •era • 4816 Blooi, am* 4817 Blood, serai 1818 Urine EXPOSURE BOO Ingestion Tngestian n -feet Ion ngestion IRllRICU. HETHOD HI1 BI» Ell CC adioaetry RUBBER or CISES 11 a) W b) 55 c) 8 1 al 6 b) 12 2 HIKES a) 0.4-1.4 ng/sl b) 0.4-1.1 ng/sl c) 0. »-1.3 ng/»l a) 0.0-0.7 ng/al b) 0.8-2.3 ng/nl c) 2.4-4.9 ng/nl a) Hot applicable b) lot applicable c) Hot applicable ) 1.10-4.30 ng/al ) 0.20-0.95 ng/al (at given Hat given lot given lot given lot given Hot given REIR \| GERIB1L IBPOBHiTIOK I BHERERCB 1 1 1 I a) 0.736 * or - 0.3ft I a) Before bias sappleaent 1 Roods. H.V. ng/il 1 i) litter 9 days on bran supplement \| Ingelfinger. J.I. b) 0.736 * or - 0.19 j c) 10 days after bran discontinuation I 1979 ng/al 1 22 g bran/day In 2 servings. »o { Clinical Pharaacology c) 0.74 t or - 0.29 1 significant effect oa digoiin. I aad Therapeatlcs ng/al 1 I 26(1): 21-23 1 libalatocy residents of I I rehabilitation center taking digoxlo \| 1 > 1 nonth. iges 79-81 yr. veights I 1 99-80 k9 1 \| Zaropean Journal of I 22-94 yr olds on digozln or I Clinical Pharmacology 1 aialtorin. 1 1S:»11-»15 1 1 1 DJOGS: 9KDG TH5B1PT; K1XS1S; BLOOD I I snai: IEIBT DISEISES i i i I i a) 11. C ng/nl I a) after overdose I Rovett, D.I. b) 6.0 ng/al I t) ICter charcoal henoperfasion I 1980 c) 1.4 ag/nl 1 c> 3 days later 1 Journal of the laerican 1 I Medical association 1 82 yr old 1 299 (14) r 1558 1 Cizziness, venltlag, atrial I 1 fibrillation I 1 1 1 BRITGSt BLOOD S«D5: HSRODIILTSIS 1 1 1 a) 1.87 » or - 0.36 I a) llthln 1 hr of dose I Padeletti, L. (3 EJ ng/il 1 b) 75-690 nln after dose I Porclani, B.C. bl 0.54 « or - 0.07 \| it delivery, after 0.2 eg. IT. 1 Scinone, G. (SE) ag/nl 1 I 1979 1 Italians given digitalis daring I International Journal 1 cr«goancy. 1 of clinical I I Pharnacology and 1 c«oes; rrnT; PRESWIRC?: BLOOD srann: i fiopdarnacy 17<2):82-S3 1 I9RIOTTC FIOID! OSBIIIC1L COBDJ 9S1ET ) 1 DISBISIS; OSOS TB881PV \| i 57.86* of dose 1 a) Total radioactivity. 6 controls I Gaalt, 9.B. 13.4** of dose 1 b) Total radioactivity, 6 patients 1 Sngden. D. 54. 50* of dose I c) Diooxla, 6 controls I Raloney. C. 14.70* of dose 1 d) Digoxin. 6 patients 1 lh«el, n. 3. 36' of dose I •) Total netabolltes. « controls f Tveeddale, !I. 0.79* of dose \| f) Total Mtabolitos. « patients 4 1979 1 5 day cnanlatlve eicretlon after 150 I Clinical Pharnacology 1 aCi (« ag) 3B-dlgoxin-12 alpha daring I and Therapeutics 25(5 1 fasted state. 1 pt 1): 499-513 1 1 1 « healthy 24-51 yr olds. « 38-70 yr 1 1 cH patients ilth •iniial renal I 1 function, on henodialysis 3s/*. 1 1 1 1 O'lSS; DBVe TRB»T: K!T1BOLR«S: \| 1 011; Btl?: C1R1D1; CO4P1BITIVE I 1 ITtlTIlTIORS: DISEISES: 1ET1BOIISK \| 1 1 U) oo ------- Iplpodophrllotoxln, 4«-deset«rl-, •-r4,C-O-2-thenvlideae-bata-D-glacopyrana«ide) f» CI» !!f JJ' r V : 'i't!? Plli0,f2;3"2ir 1 •i:2.1?.I01-:S 'S!?' ""*• S> • te • »-t«t«»rdro-5- f t-hydroiv-3, 5-di«etho«yphenTl) -»- {(4. 6 - 0- 2-th lenrlse thylene) -beta- D-gluoopTranosTl) oxy-. f 5R~ (^atLpbAy 3afwt •« DttalPJl41cVDttCB CM) 11 ~ f 9 CT1 2»77-29-2 C32-B32-013-S HI «5«.7» TISSVI Ml* B1004, plasaa 420 Urine BirosoK HOOTB I«1ectloii iB-Jwrtloa a mmcii SETHOD JtaUontrr SadioMtET IUBEH or c»sis s s illGI 20.96- 39. 1« og/il lot given Ul 26.3* ug/mi ««.** * or - 8.2K of dose SEIIUI IIFOSK1TIOI f«»k». 0 hi after 30 «Ln IT of «7 mq/H , tritium-labelled draq. Iriexponentlal decline Patients vith adTanced cancer tenkopemia. antiaeoplaotie response in 2 patieitt CSOSS; DBOG THBEIPT; CHEHOTaiBlPT; I'OPLisHS; Lttmesii: BLOOD nisu: nviwi; CEPtBBOspiiit rLoin; nets; ICOLTS; DISIISIS CMalatlTe 72 he excretion after 30 •In IT of 67 «q/aq • tritiui labelled drnq. 78.7t of adnacT radieactiTitr it eetabolite Catients Kith advanced cancer lenkopenia Intineoplaatie response in 2 patients. CHUGS: «B5« THZS1PT: CHEHO'BIBIPT; piopiisis: Ltomii; BLOOD nisii; nin«: C!PtB»ospi«i TWID: nets; ItOlTS; BISIISIS BiriEEFCE Cceaven, P.J. alien. L.B. 19751 Clinical Pharnacologr and Therapeutics 18(2):227-233 Creaven, t.3. alien, 1.1. 197Sb Clinical PhanacologT and Therapentics 18(2):227-233 00 latcadiol (8 CI) lstEa-1.3.S(10)-triene-3,17-diol. (ITbeta)- (9 CI) ?0-28-2 C18-R2I-02 « 272.»2. SP 173-179 C 1ISS01 4821 Blool, plasna «822 Illk ^tpososs Botrac Vaginal vaginal aialTlICU. HFTBOD ia ma B01BJB OF C1SIS a) 3 b> 3 a) 3 b) 3 SUE! a) 30-3000 pg/nl b) 45-2590 pg/nl a) 27-1050 pg/nl b) 40-259 pg/nl mi i i I &) Hot applicable b) lot applicable a) lot applicable b) lot applicable Gzmat iiroasaTioi a) Initial ncasnrenent and 3 hr after SO «q suppository. 23 hr values caaged Iron 5C 100 pg/nl b) Initial neasurenent and 3 hr after 100 ng soppository. 23 hr values ranged fron 65 400 pg/nl. Istinated Iron graph. Bealthv laetating volunteers. SKSOTDS: BOBHOKM: «LK: LaCiaTIOB; ------- Ethane, 2-broao-2-cklor»-1,1.1-triflaoro- 151-67-7 C2-B-Br-Cl-F3 e« 147.31, BP 50.2 C. 20 C at 2W H »q TISSUE M23 Blool 82« Breath BIPOSOBE SOOT Inhalation Inhalation aElLYTICIL BETROD OC-EC SC/HS IOBBEE OF CiSSS •1 10 b) 10 1C IMS! •) 12.55-33.40 ««/•! bj 16.55-36.95 ag/nl a) 0.01-0.15 ppa b) 0.05-0.56 ppa C) 0.02-0.42 pps d) 0.07-0.55 pps e) 0.2-0.5 ppa f) 4.0-5.0 ppa •Ml \| GEIEUL I1FOTHTIOI 1 1 I a) lot given \| •) Inestketlsed ltk » Vain nitrous b) lot given j oiifl«, 8 I/Bin oxygen and 0.<* \| halothane vapor \| b) iMstkctind >ltm 8 1/ain nitrons 1 oiia«. « 1/iin orr?«n, and 0.8.32 C, TP «0 aa -hj at 19 C iissm Ilool ETPOSOBJ BOOTE lagestioa atalYTICll HZTBOD Breath analrxer B0HBZS OF CISSS 10 iiies a) Hot given b) lot given (Ittt BS1B a) 1.0 g/1 b) 0.95 g/1 Pllt) esiiut rifosHnioi a) 1 hr after 1 gAq ethanol in orange i«ice 1 ^locose capsvle t) t hr after 200 sq cannabidiol • 1 ?/g etaaaol in oranqe jnice fitisatel fron graph. ««altiY 21-33 rr oils, t 52-85 kg. Broesiaiss, dizziness, relaxation, f««linqs of dreaainq, abnornal >«arlng. tMIIL: IDQIIS: BIOOD: DB06 IITniCTIOl; 05063; XLCOHOtS BEFESBfCI Consroe, P. Carliai, 8.1. Zulclter, 1. P. laoeria, L.I. 1979 Psrehopkarnacologr ------- m»l aleokol (8 Cl) ttnaaol (9 CD St-17-S C2-BC-0 PI 46.07, I* -117.3 C, BP 71.32 C. TP BO •• Bg at 19 C (COBflBDED) TISSUE 4826 Blood 4827 Blood 4828 Bloo« nrosms Boots aqestlon ageatloa laqestlOB lurrtrcil HETBOD SC Breath aaalrrer BOBBSB or CASES * 11 BIBGB 0-430 ag/100 ml ) Bat given ) Bat givea ) Bat given ) Bat given •1 0.38-0.06 ng/al bj 0.3-0.63 ag/al e) 0.2-0.88 ag/al i» §111 71.1 mg/mi ) 0.44 or - 0.05 mg/mi b> 0.30 + or - 0.02 •d/«l c\| 0.»8 « oc - 0.08 •q/«i 4) 0.67 * oc - 0.08 •q/«l (S.B.) a) Bot giet b) Bat glTea c) Bot glraa GIBIUL IBrOBBlTIOB llcakol and pcopoxyphaoe fond. Co toners' ca««s tro« 3 Calitornla ceatl«. tivra: osnes: BLOOD: IICOHOLS; CISB BISTCBI1S; SOICIBB; 9RV6 1BHSB B«» p«ak. 0. be after 0.2S q/tq cttaiol, pcetceatMnt vlth 0.7 aq/kg Ca carblaide t) leas neat, 0.75 hr after 0.25 q/k« • thanol, prvtraatMBt nith placebo c) Rean peak, O.S kr after 0.5 g/kg ethaBot, pretreataeat vttli 0.7 gAg ca carblaid i\ Bea* peak, 0.5 kr after 0.5 g/kg etkanol, prctreataent >itb placebo f«ak tlaes estlaateJ fraa qrapk. tleokelles, ages 23-« TC. Iraq-free. noraal cardiovaacclar, kepatic, aad renal faictioi. Ithaaol-CB carblilde interactloa caused Increased bleol aeetaldekrie. tackrcacdla, fecnaiei ataatolic tlool pre>8«re, aad decreased etkaael attabolts (at 0.5 qAq etkaml dose) . tSOSS; D30G IRIBtCTIOB: JOTITS; I1COBOIIC BE«ni>GBS: BlOOBi BIlkBOlISH; BBT1B01ITBS; BLOOD ffZSSIIBB a) 60 BBd 1BO a IB after O.»1 g/kq. iBltlal a«aa«reaent, 0.2 aq/al at 20 >la t\| 20 aa4 60 atn after 0.«3 g/kg. Tlaal •easoreaent. 0.38 aq/Bl at 180 Bla c) 20 aafl CO aU after 0.85 gAq. final aeasareaeot, O.S8 mg/mi at 180 BtB EctiBBted freB graph fioae alataistered as vodka, tonic. liae. aad sugar. Bealtky, PSTcaalogr st««ents IB Sleden, aqes 20-32 Tr, «t 60-70 kg. l«»n cOBSvaptloB of pare alcohol, 5 cl/ao. Core fmliaga of euphoria, lessenlig of tension at kigkest dose. Bore aegatln feeliBqs at Lover doses. Treqaeat coisvaers derlred greater affective benefits than rare drinkers. S»EBK»: BLOOD: PSTCBOTOPIC DB153: HPH>T'»»T«L PSYCHOIOGT; ILCOROLS BBfEBSBCB Crarey. B.R. Shav, 9.T. Bakaaara, G.S. 197* Journal of Forensic Sciences 19(11:72-80 Erien, J.r. Peackey, J.B. looals, C.I. Eogers, B.J. 1979 Clinical PharaacologT and ?kerapeatics 25 («) : as* -463 Perssoa, L. sioberg, 1. STCBSSOB, 5. 19SO Psrckopkaraaco log T (8:295-299 oo -J (HIT P1I3E) ------- Itbyl aleobol (8 en Itfcanol (9 CI) Ct-17-f tt~lt.ll. BP -117.3 C. BP 78.32 C. »P « » «« •* ~«5I5i niosm MOTI «»£"£" «829 Blool • 830 Blood •831 Slooi • 832 Blool • 833 BlOOl. plasna Ingestlon Ingest ion Ingest ion ____ Ingest ion Injection . — ~~ • — • GC BMC 19 C iflBBSB or cisss i i " a) 7 b\| » a) 6« b) «7 c) 18 5 ICOBT "~ iiioi a) lot applicable b) Bot applicable Hot given a) 0.622-1.098 mi/ml b) 0.672-0.889 ng/»l a) 120-50 sg/il b) 120-50 19/11 c) 10-360 ng/dl •ot given HOED) mi a) a. 98 g/1 b) 0 3«0 ng/al a) 0.833 » or - 0.162 ma /ml H 0.793 or - 0.10S a) 268 * or - 10 b) 272 » or - «3 ng/dl cj 260 » or - 13 __ 110 * or - 11 ng/100 •1 — etBHttl IBTOBBlTIoi t) 16 fcr after dialysis •Icohol-intoiicated 6 yr old, »t 20.2 ccaatose at 3 fcr, hypotkeEnia. «eak noise aad unfletectable blood pceuare, respiratorr arrest. HCCBOtS; IBSWIlI CTIIDBBBi C»SE BISTOBTSSS l»T»e« II yr old pbarsacist, salcide, overdose of ether drags BSUCS; BBUO UBS>; SHICIDB: insn^nn BETBOBS; «••""•!.„. eiooo; ITTW: aim: KIBBKS; B«»I». • ICOHOLS — • • — a) Dose, 0.5 g/tg, 12 hr after 0.7 ",/kg ci carblaide. Peak tine, 0.58 t,°Bo»e?'"5'Ig/kg. • kr after 0.7 no/kg ca carbialde. Peak tine 0.«7 « or - 0.07 kr lleokolles, »ean age 32 » or - '• JT yi. nean body »t 68.7 » or - zz.»J kg, Canada. ClIaDa: OISEISZSi BIOOO; DB96 IMEBICTIOB: DSO« TBSB1PI: CC1MB1TTTE ET»H»IO»S: HCOHOIIC IHIBISW: BiTiBoiiss: HETIBOIITES a) Total saacle t) Ben c) «oeea CllnicallT scber patieatB adaittel at a kospital emergency roo« it BITS: sst; BMKJD: onus tpossj ucosots peak, 60-75 nin after dose of 0.8 B«althT 22-39 rr olds. Tennessee Tt»?s»i: icw.TS: BLOOD P«SIU: BFBG IlTEftkCTtOB; CORPkBlTITE EVklBATIOWS. iSRSEBCE" ernbbaner. B.B. schvarz, ». irckives of Toxicology •3:317-320 _« — Qaeree, E.». Dickson, S.J. Hissen. »•. Panaell. L.K. 1979 joanal of analytical Toxicology 3:253-255 peacney, J.X. caglana, S. Bobinson, G.I. Re»y, R. Brian, 3.T. 19B1 clinical Piamacology and Tkerapevtics Drso, 1* Gavaler, J.S. taa Tfciel, B.H. 19S1 life sciences 28:1053-1056 Desaond, P.T. Patvardhan. R.T. Schenker, S. Roriapa, »•'• 1980 European Journal of Clinical Phariacology 18:275-278 \|IEIT .»» U) 00 00 ------- Ithyl alcohol (8 en tthanol (» CI) 60-17-5 C2-B6-0 BS US.07. HP -117.3 C, BP 78.32 C, VP 90 » at 19 C (COmilVED) 08 3» Blool , •hole Ingestion SBTHOD GC OF CASES 0 B1BGB a) 0.2910-0.551 ag/sl b) 4.05-12. SO ao/ul »B»B a) 0.019 ng/nl b) 8. DO ag/al GBBMiL IBTOBMTIOH a) tthanol. lean peaks. Peak tines, O.B13-O.S27 lir h) acetaldehyde, lean peaks. Peak Uses. 0.33-0. 59 hr Beans of 3 eiperinnts. Ethanol dose, 0.25 q/kq as 15t solution 12 hr after 0.7 igAg Ca earbiiide. Iraq-free alcoholics, ages 00-52 yr, »t 66.5-96.0 k«. lth norul cardiovascular, hepatic, and renal function. Tachycardia caused br ethanol and Ca-carbliide interaction. CBOGS; alCOROLS; IDHLTS; CM1DI: BIOOD; OBD6 IBTBBaCTIOH; DBOG SBUSE BEFBBEBCE Brian, J.r. feachey, J.B. loonis, c.I. 1990 Clinical PharaacologT and Therapeatics 27(3):»26-K33 IthTlailne, 2-(diphenylnethoiy)-H,B-aiaethyl- (8 CI) Ithanailne, 2-(dipheDyl«ethoiy)-H,H-aiBethyl- (9 CI) 55-73-1 C17-H21-K-0 BS 2^.35. BP 150-185 C at 2.0 n Hg TISSTJE 81004, eXPOSBEB BOOTE Injection Ingestion AFilTTICiL BCTBOD GC GC/HS BOB BBS OF CiSBS BUGS a) 99-196 ng/«l b) 37-83 ng/al HBAS a) 100 ng/nl b) 55 ng/al SE GEIZBU IHPOBfliTIOB a) Peaks, after SO eg IT. Continuous decline froa 1st saaple at 1 hr. Bean of 37 ng/al at 8 hr b) Peaks, 2-3 hr after SO ng, oral. (lean of 22 ng/nl at 8 hr. Bealthy 22-33 yr olds, light neal before All dose. sedation and antihistaBine effects positively correlated vith plasia level. Intlhistanlne effect but no sedation at 25-50 ng/nl. CHUGS: SSMtlVBS; » DOITS; BIOOD Fitsni: HEiPcioGic HIIIIFESTITTOBS 1ETEBEBCE Carrnthers, S.G. shoeaan, D.R. Hignite, C.Z. •zarnoff. D.I. 1978 Clinical Pharnacoloqy and Therapeutics 23(0): 375-392 oo clic acid (8 CI) -Glntaalc acid. B- (»-(((2-a>ino-1,O-dlhydro-O-ojo-S-pterialnyl)lethyl)aiino)benioyl)- (9 CI) 19-B19-H7-0« 0836 EIPOSUBE POOtB Ingestion •HalyTICiL 1BTHOD RDBBH or cisEs 40 Bot given (BUT HE1H 138.9 or - 11.5 lu/nl PtOE) GEBSBii iirosntnov Prior t-> follc acid treatment. Ifter 3 X 10 iq per day for 30 days, levels increased about 5 fold. lorao- and cligosperaic patients. Bo change in spern count, V gotile item, or ONI content per cell after folic acid treataent. IS91EL; 9B1GS; DBOG THBSJPT; TiT«ni ------- To lie Kit (8 CT) c CM' CH-S1»-»7-C6 II M1.»0 - i (Commit) tissue «837 Blood. sene •838 Exrosms loot Iioestion I B 90S t 100 IfilTTXCaU METHOD Bicroblological •HIBES OF C1SBS < «o t»ei a) 106-261 «g/il b) 7«-m eg/ml c) 300- « 80 ng/.l d) 170-330 ng/nl lot given 011 l) 167 ng/el b) 122 B9/»l C) «1« «g/ll d) 263 ng/sl •«.S « or - 7.1 Itl/Bl eiinit immuTio •I Predinlrsls, 1 ng/dnr dose b) FostaialTsis, 1 iq^Aay dose c) PraillslTSis. S loylaT dose 4) PostdlalMis, S «a/aay dow Cialysis stittcd 1 kr «ft«r do««. D«clt»« during dialysis was 26-53? Stable ancphrlc pattats aailtained tj h«o41alT»is 6 hi. 3I/k. CB06S; D90S TBBI1PT; BIOOD SISOH; CISHSBS; COW1SJT1TE ETltNTIOIS; TIT1HI1S ~ Prior to folic acid treataent. Jft«r 3 T 10 >?/daT for 30 days, lerels ion about 3 fold. lorao- and oligospetaic pattats. lo chaa ------- Cntiiicla 1»03-«6-3 iMCt COIPOSXTXOI BIKtOVI 0* BIDITElglllD It 102-IOf C (COIYIIOKD) Mil senn Saspirtto secretion Urine UOS9U sootB Peritoneal iBlectloa Ingest ion Inhalation Injection lagestlon iMLTTiciL RRBOD m Ucrobiologlcal lOHBH or cisis 7 8 11MS 3.9-l.a ng/nl a) ». 6-42.0 ag/sl b) 13.6-22.0 ag/el c) aao-12 aq/nl 4) 0.30-1. M ug/nl •) 12.6-95.8 ag/nl b) lot given mi lot given a) 22.0 ng/nl b) 17. » nq/al c) lot applicable 4) lot applicable a) 35.7 ag/Bl b) 19.3 ag/sl 6BIM1L HFOMHXOI 6 and as br after too sg dose added to 6 kr, 2 liter peritoneal dialvsate {1.5< deitrose). Initial aeasareneBt, 1.7 09/1! at 1 kr Binge of aaans Chronic renal failure patients undergoing continuous anbvlatory ceritonenl dialysis, 27-67 yr old, vt 57.3-89.3 kg. IIDin DISE1S1S: BLOOD SBKOK: miBiotics; DS«C Ttmipi; HlSTBlUBltT IR80DS a) Traekeal aspirate, 1 hr after »0 nq, aerosol B) spatas indvxrea by tracheal aspiration. 1 hr after 0 sg, aerosol c) Bronchial secretions, 0.5 and 6 hr scans after 2 eqAg, eadotrackeally n Bronckial secretlOBS, O.S and 1 kr Mans after 2 nq/kg, II. Final aeaaorenent, O.S aq/sl at C hr. c) and d) estisated fron graph. • tracheotonized 51-63 yr olds, la searosargieal nait and « adults vhose tronchlal secretions were tested for aeoplastic cells. Belgian. BtieiOl; 1B011S; BIOOD; B1OOB SnOH; •ITIBIOTICSi nSPIllTOBT SBCBRIOIS a) 0-C hr levels after 2 nq/kg HI b) 0-< br levels after 2 nq/kg, endotracbeally 51-63 vr olds, hospitalized for cranial traaaa, tracheotoaized. IIlGItll; 1DIHTS: BLOOD; BLOOt SSSOU; 1RIBIOTICS; IESPIRHOP.y SZCCRIO1S CEFEtEICB Pancorbo, S. Conty, c. 181 Intinicrobial igeats and Ckesotherapy Odio, t. Tan Laer, !. Klastersky, J. 1975 Journal of clinical Fharnacology 15:518-524 Odio, W. Tan Laer, !. Klastersky, J. 1975 Joanal of clinical Pharnacology 15:518-52* ------- Glocttol. 1,4:3.«-dianhvdro-, dinitrate. 0* (« CI) t-eioeitol, l.ttS.t-dianhrdro-. dinitrate (9 CI) 81-33-2 C«-B8-»2-08 B» 236.1«, IF 70 C TISSUE 48** Blood, serua •85 Brine El POSHES BOUT Snbllngnal Ingestion iBiinieii HETHOD SC Badionetry BOBBSS OF CISBS 10 2 I1BGB a) Bot givei b) Rot given c) Bot given 8-97 of dose BBil \| SElISal IB'OBBITIOB J 1 a) 17.9 * or - 3. 1 I a) after 5 ig. Peak time 10.0 » or ng/nl \| 1.8 ein b) 9.0 * or - 0.8 \| b) 2-isosorbide dinitrate na/il I (netabollte) after 5 eg isosorblde c) 38.* * or - 3.* I dinitrate. Peak tine 52. 1 « or - 9. ng/nl 1 sin s« \| c) S-lsosorblde diaitrate I detabolite) after 5 ig isosorbid* \| dinitrate. Peak tine tl.t » or - I 1«.« atn \| leaks I I Bealthv volinteers. Federal Republic 1 of Gcriaiv 1 1 Beadache, nausea, light-beadednesa. 1 decrease in Hood pressure, increase I In neart rate. Severe hypotension j and reversible bradvcarlla in 3 1 \| G1P.MBT: AUDITS ; BiOOD SEBDB: DTOGS: I innBOLisH; aETiBoixras 1 Bot applicable I 4-120 hr emulative excretion after 5 I ig UC- labelled drug. Ixcretioa 92* I coiplete by »8 hr. 80* excreted as I colar naterial. Vncliaaged drag I detected oily in 0-3 hr ncines, as 1 <1* of dose. Boat polar nateriel vas 1 conjugated isosorbide. 1 1 Volunteers with narnal renal and I hepatic function. 1 I OBOGS: HETIBOIISB: IRlBOimS; I OB HE: ADMITS SEFEBEBCZ Sporl-Badnn, S. tetxien, G. Kantian, B. liede, T. Ibsbagen, D. 1980 European Journal of Clinical Pharnacology 18:237-2** Down, ».B. Chasseand. i.T. Groady, E.K. 197* Journal of Pharmaceutical Sciences 63f7):1W7-11»9 UJ VD ro Glatanic acid, »-(P-(( (2,n-aiaaino-«-pteriSinTl)net»rl)»»ino)beiixoTl)-. L- (8 CI) t-eietaaic acid, »-\|t- (((2,«-diaaino-«-pteriiii>7l)BetliTl)aaino)benzorl) - (9 CI) C19-H20-B8-OS HI «0.(3 HSS9B • 9n$ Blool, serai FTSOsms Botrri In -feet ion illlTTICJL fIBTBOB J.._L_J..L _, j_ _\| ll_ !!_.!_! I HOB SIB OF CISBS 12 MBSB a\| 10{E-aj-1.SI10(B-7) noles/1 b) Bot given c) lot given d) Bot given e) Bot given RE1S \| GBI1HI IBP01B1TT.OB 1 t a) lot applicable I a) Baiqe 0 and 2 hr after b) 3. 6 » or - \| aaspectfiel dose. Biexponential 2.0X10(E-6) noles/1 \| eliilnation c\| Bephrotoxlc c) 1.6 » or - 1 c) Bonvephrotoxle 1.0:iO(£-6) noles/1 \| d) Systeiicallv toxic d) 3.2 * or - \| e) Bontoxlc t.8I10(E-6) noles/1 ( t)-e) toiicity after 250-350 ig/sq • e) 1.6 * or - I followed by leocovorla rescue 1.2X10(E-<) noles/1 I I 2?-69 vr olds with ndvaaced j aetastases. 1 I lanoea aad/oi vositing, aococitis. 1 Itukocrtopenia. platelet count I suppression, nephrotoxicitv. t lyelosappression, elevated serai I creatlntne. 1 I DRUGS'! ORTG IBSBaPT: SEOPLISHS; BLOOD t SIKH^; aOOLTS; aBHOnTIB COBPQVBOS; \ CBMOTS^llPt IB'EBEBCZ Glode, l.B. Fitnan. S.S. Fnsainoer, f.P. Posowsky, A. Papathanasopoalos. B. frei, T.., Ill 1979 Cancer 'Sesearch 39:3707-371* ------- C20-R22-I8-05 il 454.46. gP 185 C (decoBp) f ISSOB Mood. plasn 4848 Blood. seres - 4849 Cecebrosp Inal 18-50 Orine EXfOSOR ROUTE Injection Talectlon injection Tn lection HBTBOD BPIC tnxy.atic RH m HPLC BDBB31 OF C1SES 3 3 3 4 . 81(01 a) 0.6X19(1-3) - 0.5X10(E-6) soles/1 b) 0.8X10(B-3) - 1X10 O-C\| soles/1 c) 1X10 (S-4\| - 0.8X10 (S-51 coles/1 a) 8X10\|E-4t-9X1»(E-8) •oles/1 b\| SX10(B-4) -3X10(1-8) aoles/1 •oles/1 b\| 4X10(B-6)-7X10(B-8) aoles/1 at 6,986-16,633 ag b) 230-984 ag RBIB at lot givei b) lot givea c) lot given at lot given b) lot given _ a\| lot given b) not given ») 10,952 + or - 4079 b) 486.5 * or - 337.9 aq GBIEUL IBPOIMTIOI at 6 aid 48 kr after 6 br IT, HPLC c\| 6 aid 48 kr after 6 kr IT, eazvse Inhibition aetfcod e) Metabolite. 7-Hyaraxynetkotrexate. 12 and 48 kr efter 6 br IT, BPIC aetkoa Cose, 290 >g/kq latiaated ft on qrapb «-22 yr old osteosarcona patients CCRPHHITE miOlTIOBS: CBITOTRBllPT; VBRBO ST1TIS; BOW tISIlSTC; BBOVLaSSS; 910OD PUSH a\| with proteaecid, 1.7 g/sq s orally, in 4 doses/day bl lithont probeaecid Talaes are 1-120 hr levels alter 15 •In IT of 3.0 q/sq n. Coatlnnoas b {exponential aecllae. Data also for constant infusion. Cancer oatients. ages 20, 24, and 47 Ti. lo toxic effects. tines; t»us nrrmctioi: CRIROmSlPI; »K>«l»SBS: BLOOD SBBUfl: ciREStostiiiL riniB: SJTIBOIISII: IID1TS! CB1IOREI a) Bith proteaecia. 1.7 q/sq • orally in 4 ao«es/diT b) without fcobenecid 24-72 kr qeonetrie aeaas after 3.0 g/sg B IT over 15 aln. Large standard deviations. Data also for continuous In fa 3 ion. Cancer natieats, ages 20, 24, ana 47 lo toxic effects. HBSS; SRDG WTESJCTIO!!; CBIHOTHMIPT; KOPlaSHS; BIOOD STSV1; CtlZBROSPTftU. n,BIB; ICKlBCtlSH; 1B1ITS; cmiE8»W a) (letkotrexate * 7-hTaroxy-sethotrexate t 2 . 4-aianino-R (1 0) -aethylpterolc acid b) 2,4-Pla«ino-1l(10) -aethvlpterolc acid 0-48 hr cneqlative excretions a'ter ttart of >50 aq/kq, «-hr IT. Total aeses 11.5-22.1 q. Cancer patients CF1GS: CHIHOTH'El'T: IT Sim ; IIUBOLItrS; BBJS3SB1HIIT HETHODS; ITOPLiSIS; ElStlSZS ——"——• IBTEEEICB Bovell. S.K. •anq, T.-B. Rosoya. B. Satov. D.v. 1«80 Clinical Chenistry 26:734-737 Bovell. S.8. Olskea. B.I. Rice, J.I. 1979 Clinical Vharsacology and Therapeutics 26 (S) :641-««« Bovell, S.B. Olshen, B.». Pice, J.I. 1979 Clinical Phanacology and Therapeatics 26l5):41-6»6 - Donekover, B.C. Rande, K.E. DraXe, J.c. Cbabner, B.I. 1974 Clinical Pharaacoloqy an4 Tkerapeatlcs 2f(1):53-72 OJ VO ------- 6014 TMO-57-5 lf 19«.»«5 iissSi »8S1 BlOOd. plasia 91oo4. ••ran Betas irla« , HP W«.7C C. V "EXPOSOM soots Injcetlo. I.tactlot I.loctlo. Tajoctloa p 2700 C. 1 1 •• •« auimcu us US us MS at 186* C. 1 'siao»i aim _— — — • " ~~~~~ 810 .4 e«.alatl»« 4os« °Bj.«»atol4 patlnt Llf«-thr«at«.U9 tfcro.boeTtop.ala. »«COT«CT att«r pr^alsoa* ana «l.«rcaprol tkorapT- SCIB: BSISOIIIBBBT nmoosi »«!"«!?" mBBT-IS: SFMl POTSOBTW6; tISMSIS: J"«sT I" »»«»5 BWOB SraOT: BMM - a) 1st 2« kr Pal««t« •«» cfc.taatol4 arthritis. •fan aq« 57.1 • or - 11.3 Tr. sen: WHS: «»«"»'"» "'"ISi' etoeo s^soii: ITKBI: nets: BI«M»I tmnBOLtsi: aDOtTS — — UTBBMCB ClUlc.1 Pb«r»acolo9T and Tb«rap««tics 15\|»»s35»-3«0 pal.«r, »i6. 1979 JOBTBB! of »nalrtl«al Toilcology 3:2«2-2a5 Crennan, D.B. pal.er. D.G. 1979 , , aoacnal ot inalytical Tolieologr 352B2-2B5 Cll.le.1 Pkar.acol09T an 4 Tknapevties «{t)!35a-3«0 to ------- C10-S16-I6-S If 252.38 Biooa, plasma Xageatlo SBTBOB __ BPIC OF CISES 6 MISS a) 0.02-O.S og/al b) 0.3-1.5 ag/al BUI a) tot givea b) lot glTen GEIElll IfPOlBaTXOi "" a) 60 aia after 200 eg dose t) 300 ain after 200 ag dose Istiaated froa qrapk Realthr 2»-3fl yr old. wt 65-78 kg 50 Inhibition of gastric acid secretion with aean plasaa level of 0.78 ag/al. IC11TS; B100T PL1SI1; IBTOIOMC noes; nines IEFESMCE Gagler. 8. Pocks, e. Diekaann, B. 19S1 clinical Paaraacologr and Therapeutics 29(6)s7a-7»8 lazolidiaedione. C8-BC-I«-05 n 238.16. II 270-272 C (deconp) CT) 85* plasaa - 4857 Uttae lalectloa Ingest ton Inoastioa laqestloa «TBOD me Colorleetrj •PIC OF cms 6 a) c b) 6 UIGE a) 51.9-75.5 ag/al aia b) 56.8-76.1 no/al aia c) 59.5-75.5 og/al ain a) 10.59-34.58% of dose b) 3.67-U.13K of dose a) 26-320 ag/al b) 18-8* ag/al Bill ~ a) 63.2 » or - 10.3 ng/al ain b) 68.0 4 or - 6.6 c) 66.6 « or - 6.5 ag/al ain a) 22.2* * or - 8.3t of dose b) 9.52 4 or - 3.69 of dose a) 132 » or - 116 nq/al b) 59 * or - 23 og/nl 6111111 IIFOllaTIOi a) Oral, fasting. 50 ag dose r) Oral. «ltk food, 40 ag dose c) IT, 47.0-56.0 Bin infusion. area ender concentration/tine carre data Healthy 25-35 yr olds, wt S2-80 kq. itniTS; BIOOD PUSH; DBDGS-. osi»-; cntBOUKS — a) 100 ag dose. Peek at 3.0 » or - 1.6* ar •1 100 ng wltk "> g B ------- Bydantoln. 5,5-diphenyl- (8 CI\| 2.4-IniaazoUalnedione, 5.5-4iphenyl- (9 CI) 57-41-0 C.H-B12-112-02 B« 252.28, 8P 295-298 C TlSSUg 4B59 Blood, plasma 4860 91001. plasta 4W1 BlooJ, plasna 48S2 B lool. plasia (863 Blood, plassa ITWSHBS HOOTS Tnqestion Ingestion Ingestion 1 11 lection - mumcu BETBOB SS BM.C Badionetry sc ColorinetrT ,__, colorivetry - B0BB8B or CISBS 7 2 a) 70 b) 39 . 10 12 BABGB a) 1.13-1.11 nq/»l b) 0.013-0.112 ag/al c) 0.56-7.31 ng/«l 9) 1. OS- 3. 03 nq/ol e) 0.011-0.053 ug/sl f) 0.22-0,72 ag/il a) 2.16-2.46 ug/nl b) 0.0429-0.0554 og/«l C) 0.560-0.602 nq/ll a) Rot givofl b) lot given . a) 0-32.5 ug/ll b) 0-29.0 og/ul a) 7-0.4 ag/al 111 4-0.38 ug/ol / - (BUT 8E»S a) Hot giTan b) trot glren O Hot given d) lot given ej Bat given f) dot given a) 2.31 ug/il b) 0.0492 ag/ml c) 0. 983 ll!J/»l a) 14.134 » or - 10.987 no/ml b( 12.90 > or - 9.152 lld/Bl a) 15.4 »g/»l b) Not given a) sot applicable b) not applicable P»GF) G1BSB11 IBFOBH1TTOB a) pheaTtoinf oreaics b) Tree 4-OB Ktabolite, uteiica e) Conlngated 1-OH letabollte. nteaics d) Pkenrtoln, controls e) nee 4-OB n«tabollt«, controls f) Conjugated 4-OB «etabolite3. controls (0-7 lays) 0-11 flays, 6 hr after 0.1 q/day, an dose. 28-67 yt olda vith chronic renal failure, nealtby 28-37 vr olds. D11GS; DISD1SKS; HmcOHVOlSitlTS; E100D ?t>5K>t OEIBE; COIIPAEHTHE tVSimTIOBS; KIDIBT DISEaSIS: BITaBOlISK; XBIJBOIITBS; SSEDBB; I CUTS , a) Malta, at 1 hr, dlphenvlhTAantlon c) Peats, at 0.5 and 6 hr. p-bTdrotTphenyl vetaholite c) Pe»3, st 12 hr, p-hTdroiyphenTl letabollte as qlocnronlde conlagate Cose, 80.8 nq 14-c- labelled dlphenTlhrdantoin acid. B«althy 24 and 32 Tr olds, tasted c«(ore and after dose. ICOlTSi BtOOd PllSlla: HTICOHVDLSIirtS; DBTOS; BBTiHOllSB : KtTiBOHTRS a) Bales, 2-4 hr after 5.68 • or - 6.24 nq/Vg It Tenales, 2-4 hr after 4.37 » or - 2.90 iq/kq Patients on nalntenance doses for seizures. IflTCOIVtlLSaBTS: DBBS THEBIPI: BLOOD V11SHI; SET; DRBG IRT5BHCTIOB; tlPBCHTlBTDanOIlS . a) Deternined by alcrospectrofhotonetrie nethod. (lean ditference between duplicate dgternlnations, 1.0 aq/nl t) fy a Mcro-nethod at a pabllc hospital laboratory, 12 specinens lean difference between nethols, 1.3 oq/il. DBH6S; aBTTCCBVnLSanS; HKtSBfERKT BFtBODS; B10QD PlUSBa a) 10 nln and 72 hr after 250 ng IT at K nq/iln. Blaiponential decline b) 15 an] 120 hr after SOO >g IB In 4 sites. Initial seasnrenent, 1.6 oq/nl. tstlBated froe qraph. Sealthv 20-31 ft olds nt. 57.9-79.5 g. DBOI55; KBTtCOBTni.SaB1S: BIOOO PtiSIU; HOtTS; OBIBI: CONPaBITITI fvumnoBs: RITUOIISB BE?E«EBCE Borqa, 0. Boppel. c. odar-cederlof, I. Garle, 9. 1979 clinical Pharmacology and Therapeutics 26(3) : 306-314 . Albert, K.s. Ralinark. a.f.. Saknan, E. «e Idler, D.J. Vaqner, J.s. 1974 Besearch Costtanicat'ions In Cheslcal Pathology and Pharnacology 9(3)!4«3-4«9 Schaeffer, D.J. Janardao, K.G. Soiani, S. ------- BTdantoiB, 5,5-dlpheBjrl- (I CIt - c» C15-B12-»2-02 II 252.26. DP 295-29* C (COITIIVED) »86» Blood, plasaa •865 Blood. plasaa • 866 Blood, plassa 1867 11004, — Injection Ingestlon Inqestion Injection Infection alaLRTCll HBTBOD Colorlsetry GC GC GC Badlonetry - - lOHEES or cisis i 6 1 1 „ . MICE 108.5-0 og/al a) 9.0-3.9 ug/al b) 7.6-3.3 nq/Bl a) 11. 9-10. « og/al b) 11.1-10.3 Bg/al 9.5-3.75 BBOles/1 SHI lot applicable a) lot given b\| lot given a) lot applicable b) lot applicable lot applicable (MIT P.GB) GEIIB1L IirOSBlTIOI 2« hr aad 11 days after last dose of . Soae data estiaated froa graphs. tealthy 22-32 yr olds, fasted 8 kr before-3 hr after pheaytoin . ttoes; BIOOD FUS«I: JDTLTS: CC1PIB»TITE EVllOUIOIS a) Entering heaodialyzer t) leaving heeodialyzec Talves are froa 90-330 Bin of heaodialysis starting 12 hr after a fourth daily dose of 900 >g 17. S3.6 •9 total drug in dlalysate after 9 hr. 31-38« of plasaa drag Frotein-boand. 21 yr old unite nale with history of renal failure, essentially annric. hospitalized for renal transplant. DIMS; DHOG T.BEH1PT; BIOOD PLISHlJ 1COLTS; DISUSES; imCOIVOLElIITS «-20 hr after 10 ain It, 100.21 »g, labelled dose. IT infasioa of 100 •g. para-hydrozyphenyl aetabollte over 1« hr. Healthy snblect. nonnedicated >« «k. MUGS; RET1EOLISR; (miBOHTES; EltT«E3; 4DOLTS; H1IITED KIBGEOB; HOOD BtaSHl: alTICOITOLSIITS; OTOG IITmciIOl — — — — — ______ ___ — _ " BEnancl Praltt, l.». Zsiren, G.T. Patterson. J.B. Dayton, P.e. Cook, c.E. •all. B.E. 1975 Clinical Fharaacology and Therapeutics 18(H:112-120 Fraser, D.G. ladien, T.H Sotherland^ E.v. 1980 Clinical Pbanacology and Therapeutics 27 (Z): 165-169 Idler, D.S. Hart la, t. Gaabertoglio, J.G. Tozer, T.H. $pire, j-p. 1975 Cllalcal Pharnacology aa« Therapeutics 18(1):65-69 Peracca. E. Bakkl, X Bichens. ». 1978 Clinical Pharaacology and Therapeutics 2«(1).»6-51 _. „ CO ------- Bydaatola. S.S-4i»heayl- (8 CD 2,-IllexoUdI.M41oM. C 15-112-12-02 fl 252.26. «r 255-28 C TISSUB EIPOSOBB BOOTE \| 1BU.TTIC1I 1 BVTBOD 1 1 »i68 lagestion OC/iS Blood. Beraa 1 1 1 1 \| 1 «IC9 f lagestiaa BI1 Blooi. 1 sent I 1 1 1 1 1 1 1 •870 Saliva f 1 1 1 «871 ITOBBSB OF CISSS W 7 MICE U1B \| EBIBUI, nWIBMIOI 1 1 1 a) O.i-23.2 g/l a) Vat «iea I t) taaae of 'peaks b) 0.33-22 ao/1 fe\| fat give 1 »( Baaea of eaa« 1 C, , 8. <>d 12 kr after doses 1 raiflaa trot 4,0-17.9 ag/kg/day. 1 1 IpproxiMtvly 2 ao-20 yr olds I lospitalizad for seinres. 1 itnss; DIHC IBEUPT: ciiiDBEf; ( TiPirtS; imooirOLSutS: BLOOB smrn i 1 a) 9-22 "iolos/1 a) fat given ( a) 2* kr after 300 a? b) O.SB-3.C aioles/1 b\| Bat giren 1 t) 72 kr attar 300 a* I 1550 aa aspitla at 72 hr loirered 1 plteavtoin by 2T.t otec 2 hr values. j fitleated free ?rapk. 1 1 lealtkv 23-3« yr olds, Tt 50-80 kg. 1 I tioss: Dene trtitictioi: BEOOD snoa: I IBBITS: SHItl: tniCOBTOlSlBTS; I iBuetstcs: JUIPTIIIICS; BIB I I fflllBB! VRiBOUSB 1 -------- J laoestio Bit 7 a] 0.«8-l. i vaoleayl a} Vot given I a) 2» he after 300 eq 1 b\| 0.055-0.18 iol«a/l b) »ot aivea I k) 72 kr after 300 •« j I Eatieated frca grapk 1 1 1 Sealtky 23-36 re olds, »t 50-80 kg. 1 1 1 i tnss; one insBicnoB; BIOOB SEBIIB: I I jstJiTS; siiiri: i»ricoiTtn.s»rrs; \| I MllGFSICS: imPTBETICS; »U 1 THIUV: miMtXSI 1 XaeestioD 1 Urins \| 1 1 1 1 1 1 1 1 1 1 1 • 1 «872 Vriae lafectioa BS « a) O.M-1.2JT of lose a) 0.92 ot dase \| a) tkeeytoia sc b) 0.78-2.01 of dose c) S2-9VX af dose 12 _____ a) 156. 1-22«.3 •<_ b) 183. t-«25.3 aq _ . b) l.ac of lose I b\| Ree <-OB letabollte, e) lETEIEtCE DOdCOB, f.S. 1990 Clinical Pkaraacology and Terapea.tic9 27(5)s70»-7«7 Paiton, J.I. 1980 Cllaical Phanacology and Rierapeatics 27 (2fs 170-178 taiton, J.». i9»a Clialcal Pharaacology aad Tkerapeatics 27 (2>! 170-178 . . orga, O. ippel. c. c) 77« of doae \| Conjugated a-OB aetabolite f odar-cederlof, I. 1 steady state artaary recovery fraa t Carle, B. 1 12-kr daytiae collections. Beaas af r t979 t days after 0.1 agxdar, IB dos. 1 1 Bealtkr 28-37 yr olds. i I cues; DISUSE! kiriconnisuts; i ficco tttsii; OB in; coirutiraTt t ETltnilOBS; KDIBT DISS15B5: 1 BttlBOLISIJ UTkBOlITSS; S»IEEWJ 1 ItfllTS 1 a) 187.« >q \| a) 2S8 aa IT at 25 aq/ala b) 31.8 g I t\| 509 a? Tlf ia » sites 1 120-kr eaealatlve excretloaa of 1 9-p— hydroxypbeayl-5-pkeaylkydafttoin. 1 1 Icalttiy SO- 31 yr olis et. 57.9-79.5 1 fl. 1 ISMS; irricoaTJisins: BLOOD HaSRt; i HOLTS; ntm: ccwmtiTE 1 ITIM1TTOHS; BnkBOlISfl 1 Cliaical ?haraacology and nerapeatiea 2«f3\|:30«-31* Kosteabaader, B.B. Bapp, t.P. RcSovera. J.P. roster. T.S. Terrier, 0.6. Blacker. B.B. guloa. B.C. riakel. l.«. 175 Clialcal Fharaacolo^y ana Ttenpeatics 18 (») j »»9-«56 VO 00 ------- Bydaatola, 5,S-dipl«Byl- (8 CI) 2.«-Isl4azolidlMdione. 5.5-dlphenrl- K CI) 57-«1-0 C1S-B12-B2-02 if 252.26, » 295-28 C (CORIIVED) tissni 4873 Crime EXMSVBE BOUTS r»1«etioB Tngestioa . aMZTtlCll BRBOD ec BOBBER OF C»SBS 1 I1I6E 261.-38.« na/dar Ull tat applicable 6EIIUL ZTF01B1TXOI Car 1 nd « after last dose of 500 •q/dar, (101 precrllMd dose), falves iKlaa* •- »d p- hTdcoiT phenyl •. 5.S re oU, t 19 taqna aad lateral qaie aystaqaas foe T 4ra or leas after last «o»«. BROGS; CHILBBCT; USOH5I1; itnoowToisiRs: BLOOD msti; mm; eisttotiTESiniL SISTSS: BBUS TBIB»PT BEFEREICE froitt, l.». Iwiren, S.T. Patterioa, 3.E. Darton, P. 6. Cook, C.E. wall. a. I. 1975 Cllalcal Pharaacolo^r and Therapeutics 18(1):112-120 Ijdraiia 302-01-2 H-I2 B1 32.05. » 2.0 C. BF 113.5 C at 760 n Bg, SC C at 71 aa 89. 170 C at 5 ata 1ISSBE Htlne EXMsuts soun MUniCU. HBXBOD ec E0BBES 0? cisss IIB6E a) lot given b) Bot given c) lot given d) lot given HE.B a) 0. 48K of dose b) 0.075S of dose et 1.0* of dose d) 0.21% of dose GVItltli XBFOSfl&TlOB a) Slo* acetylators. 100 sg dose. 7 a«b -Jests h) ?ast aetrlatots. 100 sg dose, 13 aeblects e) Slow acetrlators. 200 nq dose, 9 cableets d) Fast acetTlators, 200 aq dose. 11 2* br nrlnes. Sim and fast acetTlators differed at both doses. p<0,02 and 0.001. resBeetiTelT (TpecteaslTe patieata HTJS3; 18111; BIITBS KIB6DOI; BflSinVHBR BBTBOOS; BIZTflXS; SITIBOITSH; IRtBTFSRElSIVI 169RS: ccsp.sativz mtaiTiois KFEBEBCE Tlnbrell. J.I. Bar-land. S.J. 179 Cllalcal Pharaacoloqj and Therapeatics 26(1): 81-88 OJ VO VO ------- co-sc-o B« m.17, in nssit »8T> Blool. glasia M76 •lool. plasaa 1 1 > 1B-1«8 C, BP 2 EIPOSHBB BOOTS Ingestlon Ingestian DO C (sole decoap) imYTICU. BOTBOD HP 1C - BPIC BOSSES OF C1SBS 15 * ~~ iiiss" a) 0.7-0.17 «g/nl b) 1.8-0.5 nj/sl e) 0. 1-0.65 ug/nl , 0.03-4.3 »g/»l ' BEaB a) Rat 9 Iran b) Wot given c) Bot glren Hot jlTOB — GZHSII iBPOBBiTioi al 2 and 8 ar Mans after 69 »g S^S'S's.'LSS'SSc M ., r".e"&~Kon£.toi.. 2 ..* 12 hi after 60 iq »ethiMole. 1 patient tt«.lo«l7 "treated '»-f7.JrKo" , .,p«rt»iroU patients. «t »».5-SS.8 kg. United «io-"• Bclsrty, B.C. Kalk, »-J- 1980 British Journal of clinical P»ar«acologr 9:137-1»3 Knight . B.I. Otter. B. to. L.C.K. lleiander. "-B- 1980 British Joarual of Clinical Phar»acolo»T 9!l«5-1»7 -..txr2-.etj7tl-y(. °»a, o o - ttsg,g — • 177 Jlool. pla-na •878 Blool, plasaa p different forss flfOSVB! BOOTS Ingest ion Ingestion 155 C, 16Z c lialTTIcil »rTBOD ec-sc us BBBBSl OF CaSBS «> 1 M 1 5 .1 _ B1BSI •) 68-7.2 ag/nl b) 390-120 ng/nl 0.31-0.63 ng/Bl l«r . . — — gin 1 ., ,ot applicable I •> Change ^^^'H"^. b> Bot applicable 1 »s™;\| Vstag error (2.0 sg/») ! Presatvre Infants »ith patent dnctns I arterlosas. 27-28 »k qestational age. ! Failare to achieve permanent d«otal 1 elosare. T ereaaed senn bilimbin. aecreased J iriaarr e«tp«t, redooea platelet I aggregation. SI bleeding. ! tsnss: WOG TBSBIPT; IBFIBIS: \| fUBSTtflMIl; CIBDIOTISCUL18 \| TX9I&SBS: B1COO PLISnfc « .1. .«m 1 Stead* state levels after 25 ng O.K79 «g/nl J 3T/anT for «-» 4«T»- ' BealthT 22-29 yr oH nedical students, on no other arags for >1» I dat«- 1 D11GS- WDSB; CEinXTOID IOTHSITIS-. 1 BIOOB USM: coaniKttB \| IftlOmtTOHS; CHIOSW OTS111C t vmn BERBBCE rriednan. I. Whltaan. T. Balsels. B.J. Sersan. B«. Jr. Harks. K.B. T«sell. Z>s. 1976 Joarnal of Clinical Pharnacologv 18 (S-«): 272-279 llvan, G. orne, •• Pertilsson, 1. rkstrand. t. Palner. L. Clinical Pnaraacology •«d Therapeatlc 1«(3)s36»-373 1 «____ ------- C19-H1S-C1-B-0* •• 357.81, M diffsrest fora* 155 C. 162 C CIJ ixssn »B79 Blool, plena ••80 Blool, clasaa mi a«r«n BlfOSBBB R001E . IngestioB Inject Ion Inlectlon BBTHOD BC-BC CC-BC OC-BC BUBB3B OF CUBS at 2 b) « c\| 3 aj 8 bt 9 37 MICE •t 0.027-0.052 « ------- ItOD It" 5S.S«7, BP 1535 C (pore), 1000-1300 C (cast). 1500 C (novgfct). 1300 C (steal), BP 3000 C. TP 1 u Hg at 1787 C. 10 •• Hg at 20«0 C TISSOB 4882 Brine BXPOSOBE BOUTS Ingest ion IU1TTTC11. BBTROD us IVHB2B OF CASES 10 sues •) lot given b) Hot given mi a) < 2 ppn b) < 2 ppn CIIEB1L IIFOBBaTIOI •) lean daily intake (supplemented) ef 66 mg, fecal lass af 111 sg, Jata froi 2 7-dav experimental periods t) Bean daily intake (nnsepplenented) of 18 mi, fecal lass af 16 sg, iata Iron 19 7-day experimental periods University stadents and enpleyees, a narse and a teacher. Unlliparous, ages 19-Z9 yr. TIIfESSEE; 01IIZ; ISOW; calCIOH; B1S>BSIQH: BIREBUS; PHOSPHORUS; CUTS; IHtBiL BBMBOIISB; PEEGMlICT SiriSEHCE iste, j.e. Schofield. r.E. Gran, R«B* 1979 ineriean Joaroal of Clinical Intcition 32:2««-291 leonicotlnic acid hvdraziie (8 CI) V-PTridineeatbezrlie add, kydrazide (9 CD 5»-85-3 C6-H7-»3-0 II 137.15, RE 171.* C TISSU! 0883 Blood, vhole EIPOSDH RODTE IHLTTTClt BOBBBS ItETHOB 0? CASES In-tection Flaoronetry a) 1 b) 1 \| 1 1 1 \| i I I «88« tJriB* 1 Digestion Sadiosetrv ~ 7 8»GB a) 28-0.9 ag/nl b) 22-3.0 ag/nl a) 2. 2- 3. 61 of dose b) 9.0-12. »t of dose c) 2.0-5.1* of dose d) 16. 1-32. S* of dose e) ««.0-52.«S of dose f) 32.6-3».3T of dose 9) 37.2-51.0' of dose h) 25.5-38.7* of dose Mil 1 "SEBIBIL tiroBBltlOI 1 1 1 a) lot applicable 1 a) Rapid aeetylator. 10 and 250 nln b) Mot applicable I after f..2 sin IT of 670 nq I b) Slo. acetylator, 10 and 425 nin 1 after •!.» nin IT of 681 nq 1 Tiezponential elinlnation. Estinated 1 fro* graph. 1 Healthy Caucasians, 29 and 50 yc old. 1 1 DBUGS: I'TiBClITES: RlSOREIEirT 1 5E1BODS: OSIIB; BtOOD; JLDILTS; 1 PITIBOLIS1; COBPJRITTTE ETlLtHTIOItS 1 a) 2. OT of dose 1 a) Isoniazid, 3 fast acetylatocs b) 10.91 of dose 1 b) Isoniazid, 4 slov acetylators c) 3.6* of dose I c) Isoniazid kydcazones. 3 fast d) 26.51 of dose I acetylators e) 09.2* of dose I d) Isoniazid hydrazoaes, « slow f) 32. I1 of dose \| acetylators g) sa.«« of dose I e) leetrliseniazid, 3 fast h) 30.5* of dose 1 acetylators 1 f) Icetrllsoniazid. « slov 1 neetylators 1 g\| Isonicotlnic acid netabolites of 1 acetylisoniazld, 3 fast acetylators 1 b) Iscnicotinic add setabolites of 1 acetylisonlazid, * sloe acetylators I Values for 2«-hr urines after •> 1 sg/kg. 1 1 Bealtky 26-39 yr aids, on nornal 1 diets and taking no nelications. to 1 hepatic or renal disease, fasting 12 1 br before and after lose. 1 1 CBTCS: OSVG THSS4PT; HRtB01IS8: IIUYtltO: UBIBC; COBP1B1TI?! 1 ITlLOiTIOKS: tDOLTS 1 HMEBESCE Boxenbann, R.G. Biegelnan. S. 197* Joarnal of Pharmaceutical sciences 63(8\|:1191-1197 Hitchell, J.K. Thorgeirsson, 0. P. Black, B. Tinbrell, J.5. Snodgrass, ».P. Potter. t.Z. Jollov, D.J. Feiser. H.5. 1975 Clinical Phamacology and Therapeotics 18(1): 70-79 inn »sei O ro ------- Keaieotiaic acid hydras-lde (8 d} 4-PrrlllBocartnxTllc acid, hrdrazldei (» ci) S4-B5-3 C8-H7-I3-0 CI 137.t5, HP 171.4 C (COITIIOBD) 4885 Urine BlfOSDBE BOOT! Injection 1111 IT 1C U. BBTBOD — Colorisetrr IVIBra or cisss a) 1 b) 1 1U«B a) 0.8-0.025 ag/ain b) 1.0-0.15 Bg/ala - - BB1I a) lot applicable b) lot applicable Giinii moBUTioi a) Bapil acetrlator, 10 and 570 aia after 5.2 ain IT of 670 ng t> Slow acetrlator, 10 and 570 aia after 5.4 aia IT of 681 ag values for Isoaiarld plus its brdrazoaes. Bstlaated fros graph. Bealthr caaeaslass, 29 and 50 yr old. BBAIGS; 1BTIBOIITBS: M1SOBBBEBT RI1B093: QBIIE; BIOOO; »6tltS; RETHOIISB; COBPHWITB ETIUJITIOIS BETEBEICB Boxeabaaa, B.e. Klegelaan, s. 1174 Journal of Pharaaceatical Sciences 63(8):1191-1197 I«oalp«cotic acid. 1->«tb}l-«-pae>fl-. atari «at«t H ci) J^'i?? iUMearbonrlle acid. 1-aethil-a-phenyl-. ethyl «»t«r (9 CI) 5 f™«»2— » C15-B21-I-02 R« 2«7.35. flt 196-189 C 1 1 «886 Blood »8«7 Blool, plasia «8S8 91001. acna EICOS4BS MVTB lalMtlan I«1«ctlon r«i«ctioR • 1BU.TTIC11 imoD ec 9C OC •DBBSB Of CiSES «) 2* b\| 13 a) 1 b) 1 a) 6 b) 8 c) 6 BUSS \| 1 •) 11-162 ag/»l b) 40-99 ag/al a) »-0.3 «/•! b) 30-0. aq/al a) lot applicable b) lot applicable c) lot applicable (HIT Mai a) 95 » or - «3 ng/al b) 6* + or - 22 nq/al a) lot applicable b) lot applicable a) 12* » or - 11 nq/al b) 13* « or - 24 »a/»l c) 130 » or - 22 nq/Bl PICI) GCItlal IIFOBBaTIOB al ViBllleal cord. TeaoBS, at birth ) Uablllcal cord, arterial, at birth Bothers received 50 mg darlag labor levels decreased as drag-birth Intervals lacreased 14 black. It caacaslaa Beoaates. BOBB 4atatlOBal age 39.4 wk, eeaa birth at 3310 g. OBIGS; pirsiiKT: BIOOO: OKIE: SWlBOlTtlS; 0«IO; 7HBIHCH COBD: IMB01» a) 15 all aad 9 hr after 5 aq/kq S»se. laitial eeasareaent 3 aq/al at 5 all. irterial vessel clasped tetveea 1st and 2nd hr t) Initial aeasBreaeat and 9 hr after 5 aa/ka dose, irterial vessel clasped betveea 1st aad »tn hr Sargieal patieats vith peripheral vascBlar disease ClSDIOTlSCIJtlB DISUSES) BIOOD E11SH1; IIIIGESICS; DBQG TBIB1OT: oancs a) Bea, peak at 1 hr follovlag 50 sg II of the hrdEochloride t) losea. peak at 1 hr follovlag 50 ag IB of the h7drachlorlde c) Vosea OB regiaea of eatrogea-progestia oral contraceptive, peak at 1 hr folloninq 50 sg It of the hTdrochlorlde lealthv 21-2* ft olds IC01TS; BIOOD: BtOOD SBBUB; II1LGESICS; CBVG HTCT1CTIOB; OB1L ccnticBPTiTis: DBDG TBEIIPT: IIICOTTCS; VBIIB lETBIIEtCZ Kahaert. B.I. Rvhaert, t.s. Ta, 1-S.l. LIB, D.C.K. 1979 laerican Joarcal of Obstetrics aad Srnecologr 133 (8): 909-91* Koska, I.J., III Kraaer, t.6. Rosagaoli. i. Sabavala, P.B. 1981 laesthesla aai laalgesia 60(1): 8-11 - Stasbaagh. J.I. Vaiaec, I.w. 1975a Jonraal of Clinical Pharaacologr 15:46-51 O LO ------- S7-82-1 C 15-B21-I-02 II 27.35. SP 186-189 C TISSUE ~ IIKSnl MOTE • 889 orlne •890 Drlne «891 Urine 1 ' -plperiainec 77-17-8 Bl 233.3* IISSOB «892 Blool Injection Injection Injection •xrosots tome Injection IHLTTICtL RETBOD «C ec oc ilUTTICIL flSTBOD «C/»S IBB BIS b) 8 el 8 2* 8 r (9 CI) b) 10 (COBT 8 USE a) »o* applicable b) lot applicable c) lot applicable lot applicable 0.5- 1H. 25 ag/»g creatlnlne "~ MISS a) 5-38 ng/sl b) 2-2 ng/al HUSO) IE1I a\| 3.17 ng b) 3.66 ag e) 3.67 ag 3.27 ng lot given GBMlll IIPOtBaTion a\| 6.3t of aose, sen b) 7.3^ of aoae, iionon e) 7.«« of aese, »onen taking eatrogen-progestin oral contraceptives l hr ensalatlve excretion after so •<) in of the hrarocliloriae. Bealthf 21-28 yr ol«» 1B01TS- OBIIE; HllGESICS; DBOS IRBIICTIOB: osn corrtiCErnvES: DIBS IBBtaPTi BtOOD» BWOD SBROH! IIICOTTCS — — • : — —~—^~~~ «l hr c«nnlatlve excretion, following 50 ng« IB as hyacocbloriae B«althv 21-30 yr oias n\|T\|£. alKl'CZSTCSS COHPftBaTITB EV»HJ»TIO»S: B»coTics; oaoss — Bothers recelvea SO ng anriag l«bo'- revels (estlnatea froa graph) anMag first 3 aays of life. l"»J* '•Fj;fll •1th aay of collection ana arag-blrth Interval. Clearance not conplete at lays. 1* black, 16 Cascaslan neonates, nean aestatlonal age 39.* «k. nean birth •t 3310 g. nines- PiBSilicy; BIOOD: OBIIE; BII1BOLTTE3: OHO: OSSI1.IC1L COBD: IKBOII tEFEUICZ Stanbangh. 3.t. (alner, !••• Journal of Clinical pkarnaeologr 15s»«-51 Stanbangh, J.E. •alner, I.I. 19T5b Jonraal of Clinical Pbacnacology 15:269-271 Knhnert, B.B. Knbnert, P.B. to, t-s.l. tin. D.C.K. anerlean Jonrnal of Obstetrics aaa Gynecology 133(8) :909-91» iizii a\| 17 * or - 1* ng/nl b) 15 » or - 13 ng/al GSIIBII. IIPOSB1TI01 •t Onblllcal eora. venoos. at "jfjj\| c "•blllcml coci, arterial, at birth nothers received 50 ng noperiaine Jnrlnq labor levels nnrelatea to arag-blrth Interval. 1* black, 16 caacaslan neonates. jean qestatlonal age J9.» vfc, nean birth •t 3310 g. CBOGS: PII6IMCT; BtOOOS OBI!: BtTWOtlKS; OHIO; niiBiliCM COID: IIWBOPI fBCZBB- Knhaart, B.S. irahnert. P.B. IB, »-s.t. Lin, D.C.K. 1979 Inerlcan Jonrnal of Obstetrics ana Gynecology 133(1): 909-91* litir PNSBI ------- XsoBlpscotIc acid, a-Bhearl-, «tfcrl ester (» CD ac"' «-H"«Tl-. etkrl ester f> CI) C1I-B19-I-O2 It 233.3* tissm M3 OrlB •89B flrlae urine S7W-77-* «-OT-C12-» M 239.55 TISS1I »89« Blood, )>!••« ETFOSVIE BOOIB fCOMIIVED) iBJeCtlOB Injection lajectioa OC ee/ns •tUBBI OF cms a) 8 b» 8 3 8 2 a) lot applicable b) fot applicable c) lot applicable lot 0.6-3.75 cnatlala* Mil a) 3.3* mg b) a. oi 19 c) 2.53 19 3.69 ag lot giT«n 7.e-dlckloro-1.2,3,-tetrakTdro-, hydrocklorUe 1-B BXPOSOn 1O01B aiutncu BETBOD »BB!B or caszs (BIT •!<:•) esiiui TiroBiitioi a) C.7* of dose, eea b) 8.01 of dose, woaea c) 5.1* cf dose, loaan taking contraceptives •8 fcr caanlative excretion after 50 BO, IB of aevexldlne kydrocklorlde. BealtkT 21-28 Tr olds ami: iiucMics; OBOG •I0»; 0111 CORS1CBPTITES; «JO« MSBMTJ aiOOD; BMOB 31108: HtCOTJCS «« kr cnanlatlve excretion follovlao 50 ag. M as kvdrocklorlde BealtkT 21-30 jt olds iiic«Tics; ranes Cotkers received 50 «q dose Beperldlie daring labor, levels leitlaated froa grapk) daring first 3 days of life, levels varied with dav of collection and dr«g-birtk Interval. Clearance not cotplete at 3 days. 1* black. 1C Caacaslan neoaates, aean geatatloaal age 39.* »k, B«aa blrtk vt 3310 g. Dines; -piisiucy: SIOOD; nun: ertiBoiiTss; onio; ntsnicii coiv; •IIBOBl BWMIJCS Staabangh. J.E. •alaer. 1.1. 1975a Joaraal of Clinical PkarBacologr 15:«<5-51 Staabangk. J.!. •alner. l.B. 1975b Journal of Clinical narnacologr 15:269-271 Kahnert, B.I. Knkaert. p.B. 19. l-S.l. IlB, D.C.K. 1979 laerlcaa Journal of Obstetrics and O Ul 133(8):90991« 6s»ui iirosuTioi .,. X.UU1 ° s Kt lealtby 21-33 yr olds, vt 59-95 g. llld gastrointestinal effects attec kr. Fatlgae or sleepiness after 2 ! «KT«S: BLOOD PLISHI, Clinical fkarsacologr and Therapeutics 25(6): 837-8»3 ------- IT987-77-6 C9-B9-C12-B.C1-B BB 238.55 (COBTIBOBD) Kalthy J1-33 Tr oias. «t 59-95 kg •114 gastroi«testlaal effects after 1 Ji. ?atig«e. or sleepiness after 2 br. Dabb, J.« State, H.B. llexanaer, T. latoccia. ».P. GeeiT. •• pe»ai«ton. B.G. clinical Jharaacology B»a Therapeatics 25 («J : 837-83 I-lscorblc acii 50-81-7 tissoB •898 899 plassa BIPOSOBS tOVTt" ingestiOB I.gestlo illtTTIC«i or cisss i i • , J a) 5».89-7J.83 ug/10(B8\| i b)". 19-77.97 ug/10(B8) l cells cTi. 88-60. IS ug/10(B»8) 1 cells i d) S.07-3>85 ag/10\|B»8) j '•71M.61-al.13 «g/10\|B8) i f) BS. 95-37.8 ag/10\|B»8) \| cells 1 1 1 1 1 t 1 1 s ! a) .57-2.16 ag/100 .1 6 J w -6»-2.83 ag/100 al I el . aa-2.63 ag/IOOal d .13-2.17.9/100 al . .36-2.60 .g/100 .1 \| f) .30-2.66 .g/100 al 1 1 1 1 1 I 1 1 1 t \ \ » — l — " sir r «««" »""""• b) Bot gi»ea j Jf!0I,!a'12Braft«rW« ag plas 300 e) Bot girea J» .^^.licylic acid (»s«. 4) Bot gi«. j J^JHe talae. 63.7 ug/10(E«8) cells ?! It ai»en 1 c' '•' *** * r Jr «S g\| II ™ » I 19 S1. Preocse Tane. I na/10(l«8) c«ll«^r iflM M plnj M0 I ag aS(. Predose »alue, 3.»8 1 «00 ag »S». Predose Tain. «3.«1 1 09/'j"(" ' , after 2000 .g plas i 600 ag »S»- Predose »alne, «2.7S I 09/10(^8) cells 1 leukocytes I B«althy stadents. aoasaokers, ! S.iJersitT of 9«bUa. Trela.a. ! T»n»iii): »D«IS: WOOD; SIOOD PIIS»»! 1 ItDKOCTTZS; II116BSICS; VBOG j ii?mcioi; Tir.gBS; TitMnr c ii05 u<3 2 hr after 500 • , IMKOCTTBS; »'^^!:,I"BH c ( . \ — "~ lEFEBEBCE •>_«, • 5 J,O n f n»« (ilsoa, C.S.B- journal of Clijical Ffcaraacology 15:36-45 loh, U.S. vilsoa. c.».s. joaraal of clinical Pharaacology 15: 36- 5 \| J t 1 1 ------- t-PcsllM, 1-(3-Bereapto-2-«ethvt-1-oopropyl)-. (S)- «2571-8S-2 C9-B1S-I-03-S II 217.31 TISSOt »900 Blood 901 urine nrosBBS soon Inqestion Inqestion alUTTICll BETHOD ILC Badiocetry ttc Sadiovetry ITTBBKI OF C»SBS 10 10 EIIGB a) lot given b) lot given a) lot qivea bj lot give* c) lot given 4) lot given BUI a) 800 » or - 7( ng/al b) 1580 » or - 90 ag/al a) 38.1 » or - 1.99* of dose b) 1.»8 » or - 0.15* of dose e) 26.2 * or - 1.11* of dose Jim ff JM f.M JIAMM Q\| W.Vn OZ QOSv (S.E.) GZIISlI IIFO1I1TIOI a) Bean peaX at 0.93 * or - 0.08 kr. »cliaa4d ietg t] B«as peak at 1.05 » or - 0.08 hr. total caaioactlTitj (as captopril •qaivalanta) Ifter 100 mq. labell«4 dos« laalthr, 18-35 ft old eancaslaaa. »t S». 2-85.0 ka, fasted before and after dose. IITIRTPSHTBISITX 1GERS: BLOOD: I1III: FICIS; RR1BOLITIS; BIDIOISOIOPfS; UOI.TS a) Captopril b) Captopril dlsalflde e) ------- •7-22-7 rasa— »»OJ Bll •0» 91004, plama (905 Vrla« tifoson BOOM" Injection In1«ctioa ln-)«ction illlTTICil SSTHOD taaloMtn/BWC — BaBioaet rr/91* I01BR or casts i 1 i »»••» 21.7-1. •< «* a°** 28-0.5 •»ol««^ 21.6-1.5* of «o«« •at applic«til« lot applicable tot applicable jaekoom. ».• S«ad«r, Cllmical WiaraacoloaT and JacfcsoB, D.T. castl. 9-c- Cl la leal SharaacologT and Tkr»p»aticB 2»\|1) ! 101-107 Jackson. O.V castl> B-C- Bm««c, B.I. Clialcal and 2» (1)-101- o 00 titkia' -93- 6.9«1. «* «°-5» C< BP '"* •>i»on »"" ------- •-BeBxeBedlsalfoBaalde. 4-CBloro-f(t)-MthTl-»O)-(tetra»7dro-2-BethTl farfsryD- (8 CI\| 1,3-Benzenedlsulfanaaide, 4-chloro-»f1\|-a«thrl-»(1\|-{(tetrai7aro-2-setByl-2-faranyljBethrl)- 719S-27- C 13-B 19-C1-B2-05-S2 N 382.90, 8? (41- foraj 19-150 C, (d- for) 16 C. (1- for) 146 C CT\| 1 nssnB i i t 4907 1 Blood, 1 cells 1 I 1 1 1 1 \| 1 I 1 1 4908 \| tlool. 1 plasaa I 1 I 1 1 1 I I 1 1 I I 4909 1 Oriae 1 \| • • 1 • • 1 I 1 I 1 1 POSHES SOtTTE gestion ngeatioB Ingestioa iiaimcii HMHOD oc oc QC IOBSB1 \| 81ISI or cisss i i 1 a) 1.82-3.53 sg/1 1 b) 1.49-2.51 sg/1 I c) 0.83-1.05 ug/al I d) 0.11-0.54 ug/al • I 1 1 1 1 1 1 1 1 1 1 t I a) 68-128 ng/al \| b) 76-84 ag/al 1 c) < 5 Bg/al 1 1 1 1 1 \| \| 1 1 I 1 8 1 a) 0.3-1.11 of dose \| b) 12. 0-14. W of dose I c) 34.6-54.2% of dose t 1 1 1 1 1 1 I 1 1 1 1 1 ISM \| GBiniL nrOIBITIOI ! •ot gives 1 a) Peaks, 1.0-5.5 hr after 50 ag, 6 •ot givea 1 subjects •ot givea 1 t) Peaks, 2 hr after 25 ag, 2 lot given I subjects 1 c) Peaks, S-ozo-aefroslde after 50 mq 1 aafrusida, 3 subjects I d) Peaks, open acid aetabolite, S-8 1 tr after SO ag Befraside. 3 subjects 1 1 Bealthy 21-24 yr olds, vt 61-84.5 kg. I no other aedleatioa at least 1 aoath 1 and fasted before dose. 1 1 OSDGS; DIBFtTICS; XlalY; BtOCD \| IllSRa; EBRBBOCITES; BSIIE; I tttaBOLlTES: 1DD1IS 1 \| ) lot given I a) Peaks. 1.5-5.5 hr after 50 ag ) 80 ng/al I b) Peaks. 2-2.5 hr after 25 ag c) lot applicable I c) S-oxo-aefruslde and its open acid 1 analogue. Dose route and tisa of 1 saaple not specified. 1 1 Healthy 21-24 rr olds, vt 61-84.5 kg. 1 BO other abdication at least 1 soath I and fasted before dose. t I Itnes; DIOBETTCS; ITaLT; B1OCD I fll$>; BUTTHBOCTTES; TOIIJ; I IIllBOLITZS; 19OHS 1 1 a) 0.49 of dose I a) Excretion of anehaaged drag b) 13.1* of dose I extrapolated to infinite tiae after c) 46.2% of dose I '0 or 25 ag, 8 sabjects 1 b) Bxcretioa of 5-oxo-aefrnside 1 aetabolite at infinite tine after 50 1 ag. 4 subjects 1 c> Excretion of open acid aetabolite 1 at infinite tiae after 50 sg, 4 1 subjects 1 1 lealthT 21-24 rr olds, vt 61-84.5 kg. 1 ac other aedicatioa at least 1 sonth 1 and fasted before dose. i I BWGS; DIURETICS; ITU.T: BIOOD \| ?l»S«lj EBTTBROCTT1S; BSISSj I B'TIBOVtTIS: IDOLTS 1 SBTSSIBCB 'leuren, H.L.J. vervey-vaB Viaaea, C.P.v. Tan Bossna. J. H. 1930 European Journal of Clinical Pharaacology 17sS9-69 Fleurea, H.L.J. Tervey— van Hissen. C.P.I. fan Eossun, J. a. 1980 European Journal of Clinical Pharaacology 17:59-69 Tleuren. B. l.J. vervey-van Tissea, C.P.u. Van Koaaua, J. M. 19«0 European Journal of Clinical Pharaacology 17:59-69 ------- BetnaaesalfoMBilide. »'-f1-hydroxT-2-(iBoproprta«lno\|«tliTl)- (8 CI) Bethnnesalfonanlde. - (•-O-hyaraxT-2-((1-metIiylethyl\|a»!lno)etByl)phenylJ- (9 Cl) 3930-20-9 C12-MO-I2-03-S 81 272. IS 1 ! tISSD! Mio Blood •911 BlOO], plasaa 1 1 1 »912 91004, plasu «913 Blood. sens 91» tain BIPOSUSJ BOOT Ingestion Ingestlon 1 1 I n lac t too 1 1 1 1 I 1 Ingestion Ingestlon I 1 1 E iMinicii HETHOD GC-EC flaoroeetry Plaorontry 'laoronetry 9C-EC 108 BIB OF C1SS 1 12 1 HUGE »ot given •C70-450 nioles/1 3-5 of dose 1.4-1.7 «9/l lot given given Ssli T eBii»i nMtunoi I BMBMCS ,' I I 10.0 ng/sl 1 lotopsy, alter 3.2 g 1 Bontagna, H. I I Groppi. 1. \| 47 yc old subject I I960 1 \| irehlTM of Toxicology \| Si otic, aqltatvd. Convulsions, 1 «3: 221-226 I ttaarcacflia, abnocaal KG. reinced \| 1 tlood pcessqr, cardiac arrest, 1 1 fibrillation, death. I 1 1 \| 1ITTRTPERTIISITE 1GEWTS; SUICIDE; I 1 IT1LT; nsns IBVSI: IOTOPSIES; t I HISmiBWT BITHOffS; 9MII; HURT; I I I01ICS; LITEF; KieiTETS; BLOOD; tTBIUS; I \| C15E 8ISTOIXES 1 -1 1 lot giT«n I 2 and 40 hr waia after 320 ng/dar 1 Johansson, S.S. \| I Recall, 8. I Healthy 20-30 rr olds, vithin 10* of 1 (ilhelBSson, c. 1 nornal weight. 1 Tea in, J.l. \| I 1980 \| fttJnced restioq and exercise heart 1 Clinical Pharaacologr j Tates. ledvced blood pressure. 1 and Tkerapentics \| I 27(5\|sS93-601 \| ElffSS: SIID1I; BIOOD PllSRi; t \| 1RIRTPEBTIIS1TE JGSHTS; COHPJS4TITI \| I IT>LOatIOHS; 1DU1IS; B1000 PSESSTOE I 1 1 1 1 lot given 1 Beans, 0 and 1(5 nin after 1 ng/kg. I Schnelle. X. I IT. Dose preceded by stimulation of I Kiel. G. I teta-receptors lth isoproterenol. I Schisz, A. \| \| 1979 I BealtkT 22-35 yr olds. \| Journal of Clinical I 1 Flarnacology 19:516-522 I eeta-adrenerglc blocking effects on 1 j heart rate, diastollc pressure, and I \| plasm lactate, glvcos, pycavate, 1 \| and free fatty acids. j 1 1 I HOGS; sfBRin; BLOOD Plisiu: BLOOD I I fsissngs: IIIIHTPBFTHSITB »GE»TS t l - t 1 t 1.C8 or - 0.07 \| a) Peaks, 2-3 hr after 160 ag. I Snndgnist, H. /I \| Elexponential decline 1 Unttila, 8. 1.»5 * or - 0.09 I t) lean peak, at 3.4 * or - 0.2 hr, 1 Sison, t. /I \| after 160 sg nith 25 ng I Feich. J.!. I hiiroeUorothiazid. 1 1979 j 1 Journal of Clinical \| 8«althy 25-57 yr olds, rt 53-86 kg. 1 Pharnacology 19:557-5«» I 1 \| CHUGS; iRTiaTPEF.T»SITS aGHIS; 1 I BIOBETICS; BIOOD SK10!l; OBIRZ; 1 I CC<)P»8»IT< ETI1QITIOI5; 1DDLS \| 1 1 . 1 1 59 »n yr old satject 1 1990 \| \| archives of Toxicology \| Clotic, agitated. Convulsions, 1 3: 221-226 1 biadycardia, abnornal ECG, redacod I 1 tlood press»re, cardiac arrest, 1 1 fibrillation, death. 1 1 t I miHTPTBTNSIVE IGtRS; SUIC1DI; 1 \| IllLT; BBUG 1BDS1; 1TIOPSIES; 1 1 BIISOSMSIIT BET HODS; BB&II; B115T: I I IIIIGS; LlflB: KID«ETS: BIOOD; U8I1E; 1 1 CIS! 1ISTOST1S I 1 1 (KTt lint) -c- h-' O ------- ------- MthanesBlfcBanilide. »•- f l-hTdroxy-2-(isopropylanlBO) ethyl)- 16 CI) Rethaaesnlfonanide, B-{a-(l-avdroTy-2-\| (l-aethylethvl) asiao) «thrl> phony 1) - \|9 CH 330-20-* C12-H20-I2-03-3 n 272.36 (COITIBVED) TISSUE «ei» orlne •20 Urine 1 EXPOSURE BOOT! Ingestlon Ingestlon I 1 IBaLTTICAl ' SETBOD ee- EC riaoroeetry fmBBB or CISES i 12 sites Wot given Rot given •EIF \| GEIZB1L moSHTIOI 1 1 I »15.7 ag/ll \| letopsy, after 3.2 q \| 1 47 rr old subject 1 1 Hiotic, agitated. Convulsions, 1 bradyeardia, abnornal ECO. redncel I Hood pressure, cardiac arrest. 1 fibrillation, death. 1 1 IBtlBTPElTSSSIYI 16SITS; SUICIDE; I mil; DIVS isnsi; itrropsiBS; I IIISmnZIT BBTHODS; BR1IH: BUST; I -tOISS; IITEH: KIDRTS; BLOOD; TUQUE: I CISE BISTOBIIS 1 1 TDK of dose \| 72 hr enialatlve eicr«tion after 160 1 14. Slight IT higher Tallies rtth 25 1 19 hTdrochlorothiaxlde. 1 \| H«althr 25-57 rr oils, vt 53-86 kg. 1 I DBBGS: IWTIHTPISTBJSITB »GSfTS: \| CIDBBT1CS; BtOOO SB BUS; OBIS!; I COHrUJkfXVE ZT1101TIOIS; ID BITS 1 BETEEEICE HoDtagaaf V. Groppl. 1. 180 Archives of Toiicologi 13:221-226 Sondgoist, B. inttlla. B. Slaon. 1. Belch. J.I. 1979 Jotmal of clinical I Pharnacologr 19: 557-56 a \| 1 1 I 9orphlMH-3-ol, 17-nethrl- 77-07-S C17-B23-I-O HI 257.3S. "IP »«-19» C IISSVS 121 Bile «922 Blool A \| ETFOSORS BOUTE Ingestion TngeatioB \ \ 1IUTTIC11 BETBO9 TLC nc RV83EI or cisss 1 i Hives Mot 9! rea Hat given mi \| czuniL urosBiTioB J t 24.0 ag/«l \| 1 I «1 vr old, ht ICO ci, »t 61.23 kg. 1 CiliforBia. 1 1 Boderate aioait of frothT heiorrhagic 1 flail in tracbeobronctal tree. 1 tolerate pnloaarr ed«ni and liiiial I evphrseaa. vaftcnlar engorgeaent of 1 liver, spleen, kidneTs. «odnlla, and 1 sflaal cord. 1 1 tBlSS; BtOOD; IITSB; BB4II; LDIGS; 1 KiDiiis: mitt: BUB; CISE HISTOEUS; I E«OG •«$!; CUIrORni; SDICIDB 1 1 2.7 ng/nl I Eiazepa alsc detected. 1 1 M vr oil. ht 160 en. «t 61.23 kg. 1 California. 1 1 Boderate aaonnt of frothy aesorrhaqic 1 fluid in tracheobroBChlal ttee. t BoSerate palioaarr edesa and nlninal t cnvnTseaa. vascnlar enqorqenrat of 1 liver, spleen, kilneTa, nedilla, and 1 atl»»l cord. 1 I osiss; BLOOD: LTTM: BBMI; io»5s; 1 niDIETS; USI1B; BTLB; C1SI BISTOSIUS; I t«a« IB1SE-. calttOBlIa: St)lCIS« I SSrEBEBC! Tnrner, J.I. Pichards. E.G. 1977 Journal of Inalrtical Toiicologj 1:103-104 Turner, J.E. Plchards, B.G. 1977 Journal of Analytical Toxicology 1:103-10* ------- Berphlaae-J-ol, 17-Mtfcyl- 77-07-S C17-B23-I-0 81 257. It, OP m-m C tissue «»23 Brl> MM Kidney eifosoBE jotrii Xageatioa Xngeation M2S \| line I «6 t«ng Ingestlon Ingestion » III TTICH BETBOD nc TIC TIC TIC IDRBSI F C1SKS 1 B1BGE t giren Ot glV«n •ot gl«n lot given 8B1I \| 6EIMAI nrOBBlTXOI 1 BETEBEBCE 1 f 1 1 8 ng/g 1 I Turner, J.S. \| I Bt chard, B.C. I 41 yr oU. ht 1«0 en. »t 61.23 kg. 1 177 j California. 1 Journal of analytical I 1 Toxicology Is 103-10 j Boderate aaoant of frothy henorrhnglc 1 I flaid li tracheobcottCial tr««, I 1 iod«rat« pnlaoaarr «4eia and linlaal I 1 «i(itT3aia. vascilar enqorqeient of I \| li»«r, splcei, kilnefs, aadalla, and I \| «$laal cord. I 1 1 \| B1HSS; BLOOD; IITEB: B81II; tOI6S; 1 \| tlftlETS; DIIIX; BTL1; C»SE BISTOEI1S: 1 1 tsns iBosz; citirosin; SOICIDJ i » > 1 1 % ag/g 1 1 Turner, J.E. \| I Blehards. P.G. \| 11 yr old, ht ICO ca, «t 61.23 kq. 1 1977 \| California. I Journal of analytical \| . ) Toxicology 1: 103-10* 1 8o8«rata aacgnt of frothy bcaorrhaqlc 1 \| (laid l» tcacbeobconclal tr««, 1 I io4«rato palaonary edeaa and ainlaal j 1 •aviyseaa. a>c«lac eagorgeaent of i 1 liT«r, spleen, kidneys, nadnlla. and j I tflnal cord. I 1 I \| DSDCS; B1OOB; LITEB; Bill I; LBKSS; \| 1 KIDBBTS; DBIK; BILE; C1SE BISTOBIZS; I I cios lensi: citiroBm; SOICIDE i . . . . i i 1 I 5. ng/g I Ilaxepaa also d«teet«d. 1 Tomer, J.E. 1 1 Blcharda, B.C. I 1 yr old. ht 160 ca. «t 61.23 k ------- Rerphinan-3-al. 17-«ethyl- 77-07-6 C17-H23-R-0 8 257.JS, IP 191-199 C (COITIRTED) 1ISS3B •927 Urine BXPOS1TBE ROUTE Ingestlox 1 I aRUYTICal HBTHOD MC BOSBZ3 or c»sss i I I sues lot giTen §EiI 2.3 B»/al CEIZBAl XnOlIWIOl «1 rr old, lit 1«0 ca. wt 61.23 kg. California. floderate aaOQBt of frothy heaorrhagic fluid in tracheobroaeial tree. •derate pnlsonarr edeaa and ainiaal espnyseaa, Tascnlar engorgesent of liTer, spleen, kidneys, aedalla, and spinal cord. DROSS; 81000: LITER; BBIIB; IDRGS; KTDRST.S: OB HE: BITE; CISE HISTOFIIS: IBIS 30SE; CILIFOBRIl; 5HICIDB IETEREICB Tacner, I.E. Eicharda, E.G. 1977 Journal of Inalftical Toticologi 1:103-104 Borphiii»«-3,1«-diol,17-(crelob«tTlaethTlJ- «2«08-S2-2 CZ1-B29-I-02 »I 327.51 CI) 1 TISSUE EXPOSURE BOOT! I IHLTTICil I ETOBS3 I BARGi I METHOD J Or CASES I 1 1 1 1 ... .1 f «928 Injection BPLC 6 a) 0.15-1. ng/sl 1 Blood, Ingestion b) 0.75-2.1 ng/al \| plassa c) O.U-O.W ng/al 1 d> 0.19-1.0 ng/sl - . • j . 1 1 I 1 1 • 1 1 1 1 r 1 1929 urine In-fectioa BPLC BEAR 6ERBBA1 IBFOSR1HOH 1 SEFE8EKCB 1 1 a) Rot giTen a) tfter 1 ag as tartrate, IT I Garer, B.C. c) Rot gireo c) HTdroxybatorphanol (wtaballte) 1 Bong, R. 1) Rot giTen I after 1 ag as tartrate, IT 1 HonkoTic. I. I dl Bylroxwbatorphanol (aetabolite) I Svigor, J.E. t after 2 ag as tartrate, IB I Tan Barken, D.R. 1 a) « b) < 1 1 a) 12- set bj 29-67" a\| Rot giTen b) Rot giTen labelled doses 1 Sayth. E.D. Ectisated fro* graph 1 1980 I Drag Setaboliss and B«althr 22-28 Tr olds, wt 56-86 kg, I Disposition Canada 1 8(0) :230-235 1 C1RAD1; ADDItS; BLOOD ttlSBA; DEIWB; \| UIICSSICS: COflMRATITE ETIltHTIORS; 1 RfTABOLISB; RET1BOLITES \| 1 1 a) 10 ail 96 hr after 1 aq as I Garer, B.C. tartrate, IT I TasiljeT, B. h) 10 aad 120 ar after 2 ag as \| Rong, R. tartrate, IB 1 Honkoric, I. labelled doses 1 Snigor, J.E. l«aa cnaolatlTe percentage of 1 Tan Harken, D. B. radioactiTitr 1 Sayth, B.D. 1 1980 BealthT 22-28 Tr olds, »t 56-86 kg, I Drag Betaboliea and Canada I Disposition 1 8(9) :230-23S C1WID1: ADVLTS; BLOOD PLASBA: ORIRE: 1 IRtLCESICS; OMPIBATITE ETRLOATIORS; 1 nrtiBOLis-i: IETABOLITIS i ------- 57-27-2 CT7-BW-B-03 •I 28S.33, up 197 c rtetastable plase), 25* C (decosp) - (» TISSUE •930 Blood, Plena •931 Blood. plassa EtPOSVn 80DTE . Injection Injection IBM met i, BETBOO ^— — — — — — m SC-EC i — i5ii or CISES 8 30 B) 320-700 ag/nl b) 51-62 ag/Bl . a) 1.900-3 ng/nl b) 60.3-72.2 ag/Bl flllV •1 555 ng/nl b) SS ag/sl - a) Bot given b) 6«.5 ag/al GIBEB11 IBFOBBITIOB — . a) Peaks, issedlately after 10 sg IT to 4 ssbleets. estlsated fros graphs rj Peaks 15 SB after 10 Bg IB to 5 t objects adBialstered as solfate. Beamy 26-32 yr olds. «t 62-100 kg. oapleasaat, dyspaorlc seasatloa terslstlBq »-« kr after infusion. 1 ssbject aaeseated aad waiting. (f(«cts less severe after iBtraaascnlar injection. MUSS; IttlBOLISB; BtOOO PllSftl; SISSICHOSBTTS; CONPlBtTIVE lUtOlTIOMS - — _ a) 2.S and B to after 0.15 sgAg single dose before sargery to 2 gioops, ages 1-6 yr and 7-15 yr. Bo effect of age b) BUiaon concentration necessary foi sapprestUg clinical slges of (aln daring nrgery, ages as IB a) aad ages 0-1 yr Bat a available for seltlple doses. S.edU. calldrea. ages 1-15 yr laalgeslc effect disappeared at «6.3-«2.7 ag/al. DIV63; DBOG TBTBlpy; tBllGESICS; piis5iri«"mBi! snBHi BIOOI) - — •-• . BEFEBEBCS Staaski. O.R. Sreeablatt, D.J. LomnstelB, E. Clinical Pharaacology ud Therapeatics 2* (1): 52- 59 _ Dahlstros. B. Bolae. P. reychtiag, H. woack. G. Paalzo, I. 1979 Clinical Pharaacology ana Therapeatics 2€(3):35»-365 Ui llCOtlM (« CIt SJ!"!?" 3'"''fcTl-2-"E«Ual«TH-. (S>- (9 CI) C10-B1»-»2 .. H..II. « <-eo c. BP 2,7 e .partial d«o.P) .t 7« .. „. 123-,25 e .t ,7 .. TIS19B <932 Blood BXPOSnS BOOTE Inkalatlon kBURIClt BETHOB " Badioaetry BOSBBS or c»sss •1 6 b) 1 a) 0-66.a «g/i b) I.S-K.a a) 21.18 «?/l b) Bot applicabU (BEIT PSE) QEBIBtL IlfOMlTIOI b) 1«»n, IkC-cotlBlse level 10-60 «in after saoklng began. Kxceeded nicotine levels at 30 and «0 Bin tata OB arlne and feces levels also* 29-60 TT old habltnal snokers. Itstalned frcs sioklng fros sldnlgtt ptior to stvdy. 0-13 beats/Bis Iscrease IB heart ««t«. Carbozyhesoglobla increase! fros 2.9« to «.«2%. lirnoiBS; SBOKIBS; IIlsO SDOII: BIOCDI HBTIBOlISBj SEPEBEBCE Irnltage. i. Bollery. c. Roasesaa, T. Kehner, E. le»i», p.j. Turner, D. 1978 Clinical Pharaacology and Tketapeutlcs 23(2):13-151 ------- •933 Blood, plan Blood. plasaa • 935 BlOOl. plana «»36 float, plama «937 alool, plant »93i lahalatlOB XaaalatiOB InhalatioB XaaalatioB iBhalatin Bhalatioa m sc Hm GC m 11 10 150 11 a) lot applicable b) Hot applicable a) 9B.«-286.7 aeol/1 b) 52.4-326. 6 BBOl/1 C) 2». 7-77.1 BBOl/1 at 10-30 B9/al b) «-22 Bf/Bl 3-63 a) lot «iT«ii b) tot gl««B ») 6.5 + oc - 1-« b) 9.9 + ot - 2-2 a) 1S.« or - «.0 BIO 1/1 b) 180.0 « oc - 90.0 BBOl/1 cl 52. » » or - 17.3 mol/1 «.13 a) 1».25 * or _ — y_l b) 13.0 » ot - 7.07 M/Bl 19.5 nq/il a) 252 » or - 1M B,/15 alB b) 25«7 « or - 122* nq/15 Bin SBOKIfSs •»»""' g^ BII1FOS a r.> -— «- » •in H.bit«l neton, .««» 20-39 T. »"« had aot sao1t«a «IBC« pt«»io«« «i«nlaq. SMICIIG; ncennt wiiccos: jinn BUMS: »OTMS8 BtOOD Pl»SB» i \| natsnyaaa. CJ , an j pt i\|ts- 1 25(5 S« „ S.3kl., ...al br.Bd. 10.7 ,7 5 hr Stokers, raqlaad B«ITEB KI»5DOg: IMlMs BLOOt » : TOB»CCOS 20-39 »r aU «o«. 1. flood health, BaiitlBi» • sMMdWl ItlCGTTWs TCBICCOS * JXc»w5 \ Inm VOTtlS! BIOOB TUSHl 1 - pharBacoloqr I I t _l ------- BlcOtlBO (S CI) C10-B1-B2 BB 162.23. BF <-•» c. BP 247 C (partial decoap) ,t 745 aa Rg. 123-125 C at 17 aa Bj. n , .. „„ „.«,,„ TISSBB 4939 4940 orln BXM3VBS BOOTB iBkalatioa " iBtalatlom IBUYTXCll oTTBOO _ III - CC .. BVBBSS or CISBS so (COVT 11BCB •) 1.0-2.8 ao/24 kc b) 0.6-2.1 Bg/24 kc lot giToa IBDED) BB1B •I 1.7 or - 0.84 •9/24 kr b> 1.78 » or - 1.02 •9/24 kr 133 * or - 19 (SB aq/100 al SEHBIL iBrosBtnoB — •1 9 days oa 22.5 * or - 6.34 M » Says OB 27.25 * 51 - ".5 °h ciq»ratte«/a«T. o.«0 mo BicotiB« each 20-30 TC old aaoker* IB good haaltk, aaUtalaloq aoraal saoklnq habits StCnBS; BICCTIBB; BLOOD PI1S81- 1QBICCOS; COHfraVaTITB BTAlniTTna^* IMITS; BMOCIOBIIS; BMBI SaBdoa saaplea. Bo correlation with dvclarol naabac of clqarettea saok«d n _ I « » * tteB.alBq iafarctiw ItULTS; BE1PT DISWSBS; OBIBB; SwaSSJ'1!? mi«w»BS: BEiSOBEBBBT IHS™ ' "ICCTI1! BlTaSOlITISs SDVKIV3 BBFBUBCB Bill. P. flarqaardt, B. 1980 Clinical PharaacolooT •ad Therapeutics 27(5):6S2-658 _ IllCOZ, B.G. Haqhes, J. Bolaad. J. 1979 British Bvdical Journal 2 (6 197): 1026-1 021 J «a.3B-I-03 It 13».7«. n 110 c U.co.p) . B? tecoip to S.203 at 200 C rani 4941 Blood. Plena 4942 Otlae EXMSVU BORS~ _. 01 tBatRIClL 1BTBOD Coloriaetrr • — __ Coloriactrr BOBBSB or c»sis M 2 hi 2 - 8 SIMS — ____ •J 68-9.0 llg/Bl b) 30-2.3 ««/•! 15.0-71, n of dOM BEtB - M Bot sirea b) Bot qiren lot glT«B CEBIBII IBfOBBHIOB •» roso of 600 a,/aq B. IT t) DOS* of 300 q a, IT Initial aeaaarea«Bt and 24 he after latlaatet froa orank DBncS; CBBflOTBBB&PT: BBOfLkSBS; 9LOOD BTT1MTS; 01SB&SBS 30C-SOO aq/aq B J5"I!.Ir.01* C«><E P»tl«at». »t 57.3-90.9 q B»BSS; CBCBOTBSBtPT: «EOPLlSiS- BLOOB J""»s WIBU umisi oittum «IT»»T«S; DISMSBS •- BEKBEBCE Ball. S.B. Toang. K. Ben]aBlB, B.S. Stevart, 0. ValdiTl«ao, B. Bolikiaa, ».T. loo, T.I. 1979 Cliaieal Phanacology aad Thenpeatica 2S(1j:2-87 Ball. s.v. Tonag, S. Bealaala, U.S. Stewart, p. Taldll«so, n. Bollklaa, l.T. loo, T.I. 1979 Clinical Phanacologr aad Therapeutics 2S(1):S2-87 ------- litrogeu 7727-37-9 II »t» H.0067. « -210.01 C, BP -195.79 C. TP 3« at a at -16.9 C TISSUE »9«3 flrine EIPOSOBE EOffTB Ingestion llalTTIClt BBTBOD Chea ins BIS OF C1SSS 19 \| RUSE I 1 lot given nut 7.6 » or - 1.6 g/4ar SIirSIL nFOSfllTIOft Expressed as teaa of 59.3 9 protein/day. Data fro «7 7-day experisental periods. University stndenta and employees, a nurse and a teacher. fnlliparons, ages 19-29 yr. ill sebleets In positive nitrogen balance. TIR:SS:E: nji»E; IBOII; CIICIDI; BIGBESITSs IMWatS: PHOSpaOBBS; OtSIS; RIKEtll BETIBOITSB: PFEC!H»CT BEFEBEBCB Ishe, J.8. Schofield. F.I. Grsa, B.B. 19T9 Aaecican Journal of Clinical littritioa 32:286-291 Iltroglyeerin (8 CT\| 1,2.1-Sropanetriol, trlnitrate (9 ci) 5?-63-0 C3-B5-B3-09 Sf 227.09, SP 2.8 C (labile), 13.5 C fstable) \| TISSB! 1 I \| f I9»« 1 91ool I 1 1 1 1 1 1 1 \| ETPOSDRE BOUTB 1 1 1 Incest Ion I 1 1 1 1 mimcm I 1ETHOD r I GC-EC 1 I 1 \| 1 1 t 1 BOH BBS I OF C1S5S 1 a) 10 b) 10 1 \| I1IGE 1 \| I a) 0-0.3 ag/sl I b) 0.1-10.0 ng/al 1 1 1 1 1 I BEil a) Not applicable b) Rot applicable 1 GBHEBiL IIFOSgiTIOS 1 I a) 9.S-H he after 7.5 »q I mstained-release dose. Vone I detected at E hr t) 0.5-« tr after 10 19 sastained release dose, lone detected at 5 hr Cardiac patients ISR1EI: DISIiSTS; HII8T DISElSBSi BIOOB; DBOG 1HMIPT: BBTSS SEKRMCB Girant, I. Salaac, F.G. 1978 Ezperientia 3«(5):«U-64« 00 Oftocin «0-5S-6 C«3-!M«-I12-C12-S2 t\ 1007.23 TISSfB • MS Blood. plasna f.WOSOE ROOtE Tnvestion alitTTIClt BET BOO Bit •OHMS OF C1SES 13 B1RSS a) 1.S-10E.9 M/al b) 27.5-181.3 pa/1 c) 0.2-9.9 po/nl d) 2».5-31.5 pg/«l l!ll a) Rot g ire a b) Bat given c) Bat given i) Hot given 6en O and 1) range of neans 9oaen betireen 35 and '0 vk gestation. flealthv 20-59 Tr old ten, lit 55-70 kq D8HGS; »S"1«1»CY; 8100B PUSH; CCHP»H!ITI»« HltOiTIOHS \| BEFEBEFCE 1 Darood, I.T. Tlilcarkala, O. Fachs, F. 1980 American Journal of Obstetrics and Gynecology 138(1) :20-2» 1 1 ------- c-aeetophenetidiae (8 CI1 leetailde. «-(0-ethoiyphenyl)- (9 CI) €2-911-2 C10-H13-B-02 H 179.21, HP 139-135 C 1906 Blood, plasaa 4917 Blood, plasna »9»8 Blood. plasia «9»9 Saliva W50 flrlne Invest ion Ingestlon Ingestlon In ------- ehenothlaziie, 10-f2-t1-etkyl-2-plperiaTl)«tliYl»-2-(aethyltU,o}- (8 CI> 10H-PfcBnotki»zlne, 10-(2-C1-«et»yl-2-piperiainyUethyl)-2-- 50-52-2 CZ1-B26-B2-S2 •I 370.56. BP T2-TI C. BP 230 C at 0.02 •• Bg 1ISS1B MSI Bloat, KTPOSQYS BOOT! . T&g«stloa 1HLTTICAL ttCTBOfi Che.. Finer o»et rj IOHBKX OF CaSSS 19 - UB6B 1100-»000 ng/nl SMI lot applicable - etiiui IIFOSUTIOI Ifter increasing doses of 1-10 ng/kg e«et 9 >k 21-65 yr old psychiatric patients la correlation betveen plasia levels and clinical affects. Plasia levels correlated «ltk dose. S1EDBB: aDIJITS: IERTOUS SYSTEM DISEASES; BLOOD; BLOOD P1»SB1; DBOC IZEtlPT; TailQtJIlItraS; COBPIRHITE iniffiTioiiSi punos i IETZBEICE B«rgllng, E. Bjornaal, I. (Ireland, t. Papp, ». (old, S. ms Journal of clinical Pharaacologr 15:178-1»« Pkenotklizim. 2-chloco-ia-\|3-(dl»ethTla«in«)pcoprl)- (« 10B-?fc««athlaliB«-10-prop»n«aln«, 2-cklora-l,l-4iMthrl- SO-53-3 CTT-B19-C1-B2-S CI) TISSUE BlOOl, !iPos»B! tours I.,esti.n alLRICl HETBOD QC-SC ffOIBEB Of CISES a) 10 b) a c> • M«SB a) lot gives b) Bot given c) lot given BE1I at 8.0 or - 2.3 b) 13. S * or - 2.7 ng/sl c) 20.3 * or - 2.3 6BBM1L IBPOBBlTICI a) 0.8-3.0 sg/ka/day c) 6.1-11.0 sg/kg/day •-1S yr olds iltk psychosis, lental retardation or schizophrenia Siae effects: salivary drooling. drossiness. urinary incontinence. tlld seizures, sedation, withdrawal, lild treiors, rigidity. Inproveient in target syiptons at plasia levels > 30 nq/il (op tia» «0-0 ng/il) . CBHSS: BSOG TREBIPT: 51000 PUSH: CBTLDIIW: B!B TOBH; BMT1L •TTIBDITIOB: IEBV90S STSTE1 DISUSES: BfBBOlOSIC BlBirESTaTIOWS BEFEBEVCI Rivera-Caliilli, L. erlesbach, P.E. Perlintter, B. 1979 Clinical Pharmacology and Therapeutics Iktlialazine, 1-krdrazino- (« CI) 1(?Bl-Pktkalazinone, krdrazooe (9 CI) e€-s«-« C8-H8-M BI 1«0.1«. ft 172-173 C TISStT! »9J3 Blool, plasia \ \ 1 !XPOSOm 5OOTE Tn lection • ABILTrTCal. BETBOB BP1C t B1SBM or cisss 2 i 11 BSB a) 0.02-0.9 UB b) 0.02-2.8 vB c) 0.8-1.9 nB 4) 0.6-1.2 OK 1 «E»» a) Bot given b) Bot given c) Vat given d) Bot given 1 I GEtmt IirOENaTIOI I (ZTEREBCE 1 1 1 a) Sapid acetylator I Hidden, T.I. b) Slo* acetylator 1 Shepherd. l.B.B. e) Bydralazine pyravic acid kydrazone 1 BOay. J.I. (aetabolite). rapid acetylator 1 tin, B-S. d) Bydralazine pyravic acid bydrazone \| 1980 (aetabolite) , slow acetylator 1 Clinical Phanacology Itter 0.1 ag/kg IT as hydrochloride 1 an! Therapeutics txtiiated froa graph 1 28 (M : 736-72 1 Hypertensives in TT I 1 1ITIS; UDOllS; BT»»5T?1SIOI; BtOOO 1 ELiSflftt aBTIBTPrHTElSIWS ftGBBTS; I 1 CC91\TTTI ITHITUTIOHS: BSTIBOITSB; 1 I «W»BOtTT!S 1 1 1 ------- fhthalallne, 1-nvdraziao- f8 CI) t(2B)-Pktkalail«<»«, hydraxow ft CI) a«-54-« C8-B8-I4 If 160.18. IP 172-173 C (COITIIOBD) TISSUE MS Urine EinSOlE BOOTS 1B11TTXCA1. METHOD oc EPIC BOHBSB OF CISES a) 29 b) 18 MICE a) 8.0-11.7* ) 10.4-1. 1* Rill a) lot given b) lot given GEBZm IirOSBlTIOI a) 2* hr excretloas (including aetabolltes) after 50-150 sg/day t) 24 hr ezcretians (inelnding netabolltes) after 200-300 sg/day Slow an* rapid acetylators Hypertensives, United Kingdos tcuus; BTBBBTZirsios: roiiB; »1TIHI?MTE»SIVE aGEBTS; 0196 THIiaCT; ItllBOLXTES BSFB8ESCS TUbrell. J.I. Rarland, S.J. FaccklBi, T. 1981 clinical Pharnacology an! Therapeutics 29 (3): 237-33 •iperaTlne. 1-(»-aninc»-6.7-dlnetl>oxv-2-«i»inazolinyH-4-(2-f»roil)- (8 CI) Mperaziae. 1-<»-aniwi-«.7-disetliozy-2-«.alnazolinvl)-4-(2-fara.nvlcarboiijlJ- (9 CI) 1921-56-9 C19-H21-B5-04 n 382.2, SB 278-280 C 1ISSDI MIS Blooi. Tlasaa I •956 Blooi, plaaia posnm BOUTS Inq«stlon HHLTI3C1L S FT HOD HPLC laoroa«trr HP1C IOTBJX or cms 7 7 HTCS \| RSI 1 GEIIB1I IIFOBRtTIOl 1 1 1 1 1 1 a) 8.6-3.2 ng/al I a) lot given 1 a) 5 control, 3 and 8 hr alter 1-2 b) a.3-1.9 ng/nl 1 b) lot given I g, single 4ose. 5.9 ag/nl at 1 hr e) 12.3-1.3 ng/il I c) lot given \| H 12 renal fatient, 3 ana 8 he 1) 6.7-0.8 ag/nl 1 9) lot given t afttr 1-2 j, slnqle Jose. ». 1 nq/ml e) »2-18 ng/nl 1 e) lot given I at 1 hr f) 3»-» ng/nl 1 f\| Cot given 1 c) Controls, 1 an4 10 hr after 3-8 1 1 «q/4»T at steadv state. 1.8 nq/nl at » 1 0-hr I I 4) Benal patient, 1 and 10 hr after \| 1 3-8 ng/dar at steady state. 1.2 I I ng/al nt 0-hr 1 1 e) Controls, 1 and 10 hr after 9-20 I I ao/da? at steadv state, 31 ng/al at 1 1 0-hr 1 1 t) lenal patients, 1 and 10 fcr after I I 9-20 eg/day at steadT state. 19 1 1 ng/el at 0-hr \| \| e)-d), 11 sablects. Xstinated fron ( I graphs. 1 1 1 1 21-67 vr olds vita hypertension and 1 1 varying degrees of renal function. 1 t I I lovered Hoed pressure 1 1 I \| ernes; 9ne iBBtm; KIIIEI DISUSES; 1 \| BTPERTIHSIOl; SIOOO PBESSTJIE: BIAOO 1 I tllSRl: COHP»S»TIT! MHH1TIOSS; I 1 ItOlTS 1 t a) Bot given ( a) ».0 * or - 1.4 la) 1 ng dcse b) Wot giv«tt I ig/nl It) 1 ng dos« * 80 ng propranolol c) Bot given I b) 4.8 * or - 0.8 I c) 1 ng dose * 100 ng prinidolol 1 ng/nl 1 (eats 1 c) 2.7 » or - 0.7 I 1 ng/nl I Healthy, nornotensive 25-35 yr olds 1 1 t 1 UUtTS: B1CCD VlKHt; I \| »fTIFTP!BT»»SIV! jr.ETTS; DUG 1 \| IRCBICTIO* I 1 tlFESEBCE oxenthal. D.T. 'obbs, D. ffrise, R.B. «oeey. T.I. artinez, E.(. Oaesti. e. 1980 Clinical Ihamacology and Therapeutics 27 (6): 779-783 Elliott, B.I. IM, r. Snsner, D.J. Hera llth, P.I. Fell, J.I. 1981 Clinical pharaacology an 4 Therapeutics 29 (3) l 303-309 N) ------- e, 1-(1-pb«aylcyclofc«yl) 77-10-1 C17-B25-1 B« 2B3.3!, «f »< < plasia M59 Blool. viol* Brain Heart Kidney :. BP 135-137 C at 1 •• Bg BIPOSOBB BOTTTB sc OC/IIS 9C ec IS SO 10-812 »9/l 10-180 ag/al lot a««et«a-12.»00 ag/a 0,050-0.060 og/g 0.060-0.190 ag/« ,35 73 3 ma/ml .Ot not l^_ (1KI PWM I Bailey. 1 Shan - a;rr..?9^.trpb..cyriiai^.si.r.a s B^rSW-S-S. ? car •cciaent. 1 «lciae. . joaraal of .nalytical £"™lo,T 3:235-237 cuiTOBti: MOOD: BRM»: »UTOPS1«S ! BBtisSi nane »B«SB, if THBO UUTSXS: I i SWOB! BIOOD —«« ' I _i. "t I Claray. I I Crarey. eh«iattT \| attrlbatad to araq. MBITIBS: BIOOB8 BSU«S 3:235-237 1 C»1ITO»I»1 C»»«BS! M.COB: BSHi; I Bailey, Sfca», - i i ! ?oS"io,; 5^34:537- 1 ilBICIira: aOTOPSlSS N5 N5 ------- Fiperlllne, t-(l-pbenylcrclohexyl)- 77-10-1 C17-B25-1 If 23.38. IP 46 C. B? 135-137 C at 1 •• Hg (CO«TI>VEO) 1ISSVE 4963 liter 4964 tang EXPOSBBE EODII «IIirrlC«t BET BOD 6C «c •raBBB or CASES 6 4 BIKE 0.028-5.100 ug/g 0.090-0.640 ag/g IE I lot given _ Bot gir«n 6E1TEB1L IIFOB91TIOI Eese anknomi aatopsies, 18 ft old vonan, 17-26 IT cia ten. Death pheneyelidlne-Eelat«a bat not attributed to Iraq. 3 hanicides, 2 Sr«g OTerdoses, 1 car accident. 1 soicHa. CailTOHlIk; ClDftTZBS: BLOOD; BR»I»; KIDIZTS; 1TT1S; WIGS; BIOICC01UL»TIO»: 9BOS iBOSI; fOBEISIC HZtlCIlE; JOTOPSIIS - tese nakaovB latopsies, 11 yr oil vocan, 17-2* Tr oH «•». Death pheacrclldine-relited knt not attritrat«4 to druq. CtllfOSUta: C1D1TE8S: BIOOD: BSklll; KIDIETS; iiTti: mes; tlOlCCQSDtlTIOIt; OBOS iBOSI; FOHCTSIC 1IDICI1S BEFEBEBCE Ball«T. O.R. Shaw, H.F. EobinsoB, P.I. Cuba, J.J. 1979 Joaroal of Analytical Tolicoloqj 3:235-237 Bailey, D.I. Shaw. R.F. Pobinson, P.T. Gabaf J.J. 1979 Journal of inalytical Toilcoloqy 3:235-237 t Iparidln. 3- ((1,3-b«niodioiol-5-yloxT> »«tayl) -- («-f laoroplwnyl) -, trans- (-) - t1B6»-08-7 C19-B20-T-I-C3 II 329.39 K3 LO 1ISSBB • 965 BlooS. plasma •irosom IOBTE Tnqestlon 1»»ITTICH RETBOD QC HJBB!S OF C1SES 6 BUG! a) 1-11 ng/il b) 19-47 ng/al c) 55-106 nqAil d) <3-8 ng/d e) 8-37 ng/al f) 35-86 ng/al B:IB al 7.67 ng/«l b) 33.7 ng/il c) 72.0 ng/al 1) lot gle« e) lot given n Bot given GEBtBIl IBFOBB11IOI a) PeaVs, 0.38 ngAq c) P«a\ir 0.77 agAq c) teaks, 1.14 ag/kq a) StealT state, 0.14-0.18 ag/kg/9aT e) Steady state, 0.34-0.45 iq /leg/day f) Stealy state. 0.68-0.89 «g/ltg/aay. (2 sublects) Single-4os« stady («-c) , 3 cases. peats at 2-8 hr. laltlple-dose study (d-f) , 3 cases, steady state reached < 1 ------- PlperlftlM, 3-lt»-«ethorypheiK«y)«ethyl»-1-sethyl-»-phe«yl-. (3H-tr»»s)- 5S8S9-S8- CZO-«25-B-02 If 311.»S 1ISSWS Blood, plasaa «9«7 Vriae EIPOSOBE ROUTE Ingestlon Injection Ingest Ion IBalYTICal HRBOO sc ladioaetry tOIBSB or casss •1 ' b) i 2 Bal6< a) 40-3.5 ng/al b) 55-5.8 ng/al a) 61-8 K of radioactivity b) 3-7.2 ag c) lot given RCtl a) fot applicable b) lot applicable a) Bot gives b) Bot given c) 0.02 ag a) 5 aln and 27 hr after 20 Bin If of 2. 5 eg. continuous blexpoaential decliae I) 3 Bad 50 hr after (00 eg, oral. Initial valae, »1 ag/al at fl.S hr. Bealthy volaateers oa BO other dregs. lealting 1.5 hr after SOO ag dose. DBOGS: HST1BC1ISB; »KIDEPSESSITE I6CTTS; BtOOt PUSH; CORPB1TITE lYUVmOfS; BSTIBOtltBS; OKlBI a) cnsvlatlve ercretion op to SO hr after «»0 eg of 1C-labelled drag. lost as eetatolites. laoant iadepeadent cf arine acidity (pB .f-7.9) b) Is fesoxetiae, pH 4.8-5.3 c) ts feaoietiB, pB 7.2-7.9. Healthy 37 yr olds, BO other dregs. Toaltiag 1.5 hr after COO ag dose. mass: siTitciiss; IBTIOCPIESSIT: 1GBWTS; BIOOD P11SII1: COHPM1TITI It»initIO»S; HZT1BOIITJS) OBIWB ~ nrzB2Bci IMd, J. Christeasea. J.I. Beehgaard. (. flolaader, L. Larssoa, B. acta Pharsacologica et foxicologlca 44s 177-184 land. J. ChriBteasen. J-»- Bechgaard, I. HolBBder, L. larsson, B. 1979 acta pharBacologica et Toxicologica 4»s177-1«4 NJ PIati»a, dia»ai«edichloro-, cia- f8 CI) tlatlaaa. dlasBlBedichloro-, (SP-«-2J- (9 C12-H«-M-Pt lit 300.01; tlSUB! «««e BlOOi. plasaa «9«« giool. EXPOSOSK BOBTI In lection iBlectioB --- aminictt ISTWD us us 10R8ES or cisis 8 1 a) 30.-13.3 iaoles/1 b) lot givea Rot applicable IIITT a) lot glrea i) 1.S + or - 0.6 moles/1 8.69 ag/Bl PIG1) \| GEIMiL IBPOtHTICI a) 1 aa4 B hr after start of 1-hr IT of 70 ag/sq a. Biphaslc decline b) 21 days after 1-hr IT Of 70 eg/so. • Icn-protelB-Boand Pt < 0.5 aaoles/1 ty 45 hr Patients vith breast aad ovariaa carciBoaa, with aoraal renal and hepatic fnactloB. tSUSS; CHEBOTBBB1PT: ISOP1JSBS; BLOOD iiisifii npltff: PHT1WB _T — it ead of 15 aia IT. Bose, 17S ag (100 ag/84 a). BiexpoBential d«elte. a« yr 914 «ith ovariaa aJenocarclnoia. MOSS: ciMonretm: PIITIIOB; BIOOO titsiii: RtopiisRs; atniSi cwcmoits BIFEESHCi Goraley. P.!. Bull, J.R. leEoy, l.P. cysyt. B. 1979 Clinical Pharaacology and Therapeutics 25(31:311-357 Tenorkea. J.E. ran der Tijgh. D.J.F. Pinedo. H.B. 1980 Research Cosaanicatlons in Cheaical Pathology and Pharaacology 28 (21 '. 3 19-3 28 ------- Platlaaa, dlauinediehloEO-, ci«- (8 ci) Platlaia, diassinedirtloro-, (SP-»-2\|- (» 1J««3-27-1 CI) C12-B6-»2-Pt Rl 300.05 (COITXVffED) TISSUE 4970 Brine 4971 Brine EIMSUn BOOH Injection Injection iMtTTIClL a ETHOS us cc us IBBBSS OF C15S5 8 1 MI6I 2-23.5* of dose 21-0 nq/nl nil lot given lot given GEimi nvciiiTioB B«an cnnvlativw excretion 0.5-24 hr after 1 hr IV of 70 nq/sq n. 1».8« excrete! bv 2 hr. Patients vith breast and ovarian carclnona, vith nocnal r«aal an4 tepatlc function . OITieS; CIZBOTBEIaPT; MOPHSBS; BLOOD E11SH1? UBIVZ* PL&TIVQ1 S and 50 hr after start of 6 hr IV of 131 nq (V aq/sq n). Initial •easnrenent, 3.4 aq/al. SatinateS fion qraph. lestienlar cancer patient, Barvland. piiTinx: nzTais; DKHS THZIIPT; CBZBOTHERaPT; B10PLJIS11S! QBIVES RlBTlalD: ZlSDSt!tEIT SBTEODS BEPEIIVCE Gornler, P.I. Boll, J.H. LettOT, A. P. CysTk, B. 1979 Clinical Pharaaeoloqr and Therapeutics 25 13) : 351-357 tetoy, ».?. Vehlinq, I. Cornlev, I. Eqoria, H. ostrov, s. Bachar. V. viernik. P. 1980 cancer Treatnent Teports 64(1): 123-132 fctassina: •>a I 39.098. IP 63.2 C, BP 765.5 C, TP 100 an Hq at 590 C ro TISSOS •972 irlae IIPOSORE BODT5 Taqestloa i«»inie»i BETHOD Plane photonetr? lUBBIB or cisss 12 sues a) 12.3-56.0 a!q b) 19.6-61.9 aEq c) «1. 6-65.1 ntq 3) «1.«-6«.7 alq R<>« a) 43.0 or - 11. a aEq b> 0.6 or - 11.« aEq c) 50.5 » or - 7.6 al ------- tegna-1,4-aien«-3.20-aione. 11beta.17.21-trlhvdroiT- (8 CI) Piegna-1,4-«ene-3.20-dione. 11.17,21-trihydrorv-. (llbeta)- (9 CI> 50-24-8 M 360. «». n 240-241 C (decoap) 1ISSBE 4973 Blood, sera BTPOSORI B001S Injection Ingest ion 1MIYTXCU HBTHOD 1 EH HOBBSB or cisss a) 12 b) 3 O « d) 4 S1IGE a) Rot given b) lot given c) lot given 4) 2.200-90 ng/nl IBAR a) 198 * or - 9 ng/il b) 299 » or - 27 ng/nl c) 761 « or - 177 ng/nl 3) lot applicable • — a) lean peak after 10 nc" TISSOB •97» Blood, plasia EIJOSBK ROOTI Inject Ian tngestion ilAiniCll BITHOB SadioeetEf I OB BIS or CISES 3 B11GE a) 2.32-3.49 ng/nl b) «.2-».7« ng/nl c) 0.35-1. SS ng/nl d) 3.86-».59 ng/»l BEII a) 2.90 ng/nl b) ».»5 ng/»l c) 0.85 ng/nl a) . 21 ng/nl a) rlaniaolide, IT b) «8eta-OB netabolite after flnnisolide, IT c) flanlsolide. Oral d\| «B9ta-OB netabolite after flanUallde, oral 0-8 hr average level (area under the cnrv/t) after 2 ng. Healthv nen, 68.2-95.9 kg, no other n«dicatlon > 2 vk. riDES; IHTI-IITUBBITOBT 1CI»TS: COFKCOSIHOIBS: SBT»BOIISB; BtMBOtlTIS: BIOOB PI»SH»; BBIM: CC»P»»IITITI BTatOaTICSS; iBOITS BET£B£BCB Chaplin, B. D. Rooks, «•» II Strenson, S.H. Cooper, S.C. Herenberg, C. Cha. .I. 1980 Clinical Pharnacologr and Therapeutics 27(3);»02-«13 - to ,. ,. «, 50-02-2 C22-B29-r-05 Bl 392.«5. DP 262-2«« C, 2S8-271 C (Irth patent] 1TSSOE Blood. plasna ' \ \ \ \ \ .- — EXPOSOBB BOOTS Ingestion 1 1 \ \ —\ llALTTICAl BETBOD BIl V \ —\ BtJBBEB or CISBS 1 B1RGS a) 0. 5-4.4 ng egaiv/nl b) 15.5-35 ng/nl c) 185-38 ng/nl a) 63-40 ng/nl I tirr BEAR a) Rot given b) Rot applicable c> »ot applicable a) Rot applicable E 9161) 1 1 _ ) Pretreatnent valaes 1 Baggan, D-B. t) 10 nin ana 1.5 hr after eight 1 Teh, F.C. 1.5-ng tablets, rinal value. 35 1 Batalia, B. mynl at 10 hr 1 Ditzler, C.A. c) 10 nin ana 10 hr after 10-30 nin 1 BcBahon, P.O. « oVana'lO hr after 12 ng as 1 Clinical Pharnacologv eliiir. Initial value. 63 ng/nl at ) »»d Therapeutics 10 nin ' * l J Intinated fro* graph. 1 1 normal 1S-26 It olds. fast«d 1 overnight. ' 1 Dines: COH?»BMITS STIWWIOIS; BLOOD i PtlSSV; TJUIBt; WTltS; H!?i>OLIS8 1 ------- Prgna-1,«-cJiene-3,29-dione, 9-flaoro-t1b«ta,17,2t-trikrdroij-16alpha-«eth/l- (8 CI) rTe«na-1,-g»a-1,0-dtene-3,20-aione, 9-tlnoro-l1,n-aihjarory-16-aethjl-21-(pKosphonootj)-, (11bet».16alpha)- (9 CI) 312-93-S C32-H30-T-08-P II 72.« TISSUE »977 Bloal, plisai KieOSnffE BOOT! Inlectlon llURICal HETBOB BI1 imiBSS or cisss ) 8 b) 8 c) 8 «) 9 BUGS a) 22.7-78.0 ag/al b) T7.0-158 ag/al c) 157-207 ng/»l d) 65-1,217 ng/al BE A I ») 9.1 «g/l b) 117 oq/«l C) 187 ng/al d) 896 ng/al GZIIB1L IITOBHITIOI a) 0.03 aq/kg dose b) 0. 1 aq/kg dose c) 0.20 aq/kg dose 9) 1.0 ag/kg dose ^-intercepts of seai-log plats of dcxaaethasoae alcohol concentration »« tiae after indicated doses. Horaal 18-26 yr olds. D3UGS: G10COCOBTICOIBS: STIBOIDS; I1COD P11SR1; IDOLTS; aBTlBOHSB; ItTkBOlIIES SCrt&EHCE \| Hare, I.E. Teh, K.c. Ditzler, C.I. RcRahon, F.G. Hugger, D.S. 1975 Clinical Pharaacologr and Therapeutics 18 (3) : 330-337 VxopionaniliOe. «-{1-phenethTl-»-piperLdTll-, citrate (1:1) (« CI) tiopaaauide. «-»he«Tl-"-{1-(2-phenTlethIl)-»-piperidlBTl)-, 2-ajdroxr-1.2,3-propanetricarbx»Tlate (1:1) (9 CI) MO-73-8 C 22-R28-12-O.CC-H8-07 II 528.S, 1? 19-151 C ITS SHE »78 Blood. 9«t«u EIIOStltE BOOH Injection liilTTICil HETBOD Ilk 108 BBS or cuss a) 5 b) t e) 3 Bivei a) 352.8-8 ng/al b) 91.6-5 ng/al c) 55.31 ng/al am a) lot applicable b> Kot applicable c) lot applicable GE11S1L IirOBRlTIOl I 1 a) 1.0 ug/sq a b) 0.5 ag/sq a e) 0.1 »g/sg, a tinge of Beau, 0-2 hr after dose • 28-C9 fr olds, vita nearo- or neck cancer surgery. DBDGS: OBOG TBSB1PT; BUMS SEBUI; cnniostint rtaio; asiiii; isutis nrnEBCE Schleiier, 9. Benfaalni, B. Eisele, 3. Henderson. 6. 1978 Clinical Pharaacology and Therapeutics 23<2):188-194 ------- . ^U-1.2.3-pr0p»«tri«rb«Tl.t. ,1,1, (, CD 990-73-8, C22-B28-I2-O.C6-B8-07 11 528. »5. BP 1»V151 C (COITIBVE9) !»« •979 Cerebrosp inal fluid •989 urine EMOSSBE 80HTE Injection Injection IMiTTIClL BETBOD BIk BI1 — BBBBSR OF CIS3S 1 1 B1WGE 0.1-3 ng/nl tot applicable Bill Wot applicable 21 of dose GEIEBAL i«rUKB«IiV>« 5 and 30 ala after 1.0 ng/sg •. final neasmrenent, 1.25 ng/nl at » BE. leorosnrgical patients DBDGS; DBD6 tBZRWT; BIOOD SEBOS: CEBEBEOSPIBIL FlCWS BBHB; kDOITS C«e«latie excretion in M-hr nrines after 1.0 ng/sg n lenrosvrgical patient OBOGS: DBOG THEBIPT; BIOOD SEBOB; CEBtBBOSPIBtl FIBIB! USIBBS IDBWS _. — Schleimr, K. Senfanini. E. Eisele, 3. Henderson. S. 1978 Clinical pkarnacology end Therapeutics 23(2)t188-19» Schleiner, a. Benfailni. E. Eisele, J. Henderson, C. 1978 Clinical Pharnacology and Therapeutics 23(2):188-19« ... propionic acid, 2-rp-c»loroplie»orTl-2-net»yl- J8 Frcpanoic acid, 2-<»-chloropbenorr)-2-nethyl- C9 862-09-7 C10-B11-C1-03 II 21«.66. HP 118-119 C tISSWE • 981 Blood, pi a ana EIPOSDBX BOOTE Ingestion »»»tmc«i B ETHOS 9PLC tmess or cisis I1I6E lot giren am 96.1 * or - 17.7 «1/nl lean steady state valves, 2 I Iq/day for « «k. Bealtkr 22-35 TT olds, no nedieations for 2 preceding ». EiOGS: eturcmii: BIOOB PI»SB»: DSOS IHBBIJT: »BBWS: CORPIMTITE tf»lB»TIO»S: BE11BOLITES: CB1OIME CBSAHC COIPCIIIIDS BEFEHEBCE Bjornssoa, T.D. Reffin, P.J. Svezey. S. BlaschVe, T.F. 1979 Jonrnal of Phamacology and Experlnental Tterapeotics 210(3) :316-321 — — to 00 Propionitrile, 3-anino- (8 Cl) Fropnnenltrile, 3-anino- (9 CII 151-18-8 £f ToTo!. BP 185 C at 760 nn Hg. 87-89 C «t 20 nn Hg, «6-«9 C at 5 .. Hg. 50-55 C at 3 n. Bg TISSOE •9«2 Vrine ^ BTPOSJB! FOOT Ingest ion kllllTTICkl BE? ROD Photoaetry \ \ . — BOBBSB OF CISES 1 8i»G! Hot given 9E>B 16.3 « or - 0.6* of dose GIBIB1L IBTOBBinOB Steady state excretion, days 2-U on 2?0 »g/6 lir. Brine collected at drag aanintstratlon. 1< yr old blaclt »ltn nassive e lo ids renoved surgically. WIGS; 99.UG IBSBkPI; OBI1E: BRUCLISBl BETkBOlIIES; EBITUSS BETEBEBCE Fleisher, J.R. Peacock. I.B. Ctvapil. B. 1978 Clinical Pharnacology ana Therapeutics 23(5)i« 29-52 ------- pyridiae, 2-(alpha-(2-r 1 1 sires a) 0.01-0.14 ag/al b) lot gives c) lot given Sot given Rot given a) lot qiT«n b) lot given lot given HEIR a) 0.112 * or - 0.062 «g/Bl bl 1.9 ug/al c) 30 ng/al 5.3 ag/g . 4.0 ng/g a) «.« ng/g b) 115 ug/g 19 ng/il Givnti nroBunoi a) 3 Ml«s. 3 f«tl«s, n«ta »t £7.17 » or - 8.2 Itg. 2 hr after IS «g of the lalaatc b) Ivtopsv, It yr oil »al«, possible occ4ose e) Jutopsj, * yr old, snlclte Dunes; DSOS unsi; SUICIDE: iiriopsigs: cisi BisTOtiis; «iis»«tliyl)-, hydroxide, later salt, <«B-trans) - ?9 CT) iO-59-9 CW-B17-I3-0-S2 ill MS. 50 TISSUS >988 Blood, plassa Ttposns? gonre Injection aHLTTICIL RETBOD WLC BORBIB or CISES t BlIGE a) 32.8-40. ng/al b) 0.9-2.6 ag/al (SETT HZll a) 36.8 ng/»l b) 1.65 ag/al P»Ct) GIlEBat IHPOailTIOS a) If tec 5 iln t) after 7 hr Dose, 10 sin IT of 1 g Healthy 27-7 yr olds tBBCS; IMTIEIOTICS; S»EDK; DliTin!; EICOB pusiu; HDUITS SEFEEERCE Rrvldsson, &. Borga, O. alvan, G. 1979 clinical Fliaraacology and Therapeutics 25(«):870-87$ ------- lyridlnivn. 1-a2-c»rtory-8-oio-7-(2-(2-thiiiyl) aeetMl4o-)-S-thla-1-aTabicjclo(a.2.0) oct-2-en-3-yl) »ethyl\|-, hydroxide, tuer salt (« CD (T»») PyrHiBiaa. 1-(f2-carborr-8-oio-7-{{2-tnienrlacetTl\|«Bi»oJ-S-thl»-1-a«biciclO'(».2.0)oct-2-en-3-rl) ««tyl)-, hydroxide, liner salt, (6S-tr»nsJ - (9 CD 50-59-9 C19-H17-I3-0«-S2 R« »15.50 (COITIIDEO) Tissue •989 urine SIPOSOBt BOOTS In -(set Ion alaLTlICal nTHOD RPLC IVIBEB or CUBS IM6I •at giTon Mil _ 71 * or - 1OT of dose SB* Hll I»K»BalIOI 30 hr excretion after 10 »in IT of 1 9 Healthy 27-m yr olds usffss; iHTrpiDircs; SWBDB»J mire; EtOOD PLlSai; 1 DOITS BSKBWCE IrTidssoa, i. Bocga. 0. HT»B. s. 1979 Clinical Fbariacologr ana Tkerapentics ±5 (6) 1 870-876 _ trriainiiiB, 2-fociTl-1-ietbrl-> chloride, oxin (8 CI) tTridinlm, 2-(CBTac«Ti«i"o]«ethyl\|-t-iethTl. chloride (9 CI) 51-15-0 C7-H9-»2-O.Cl «« 172,«3, 8« 235-238 C (decoap) IISSD3 •990 Blood, plasna t 1 1 • 991 urine ntOSHBB B00TB Tn-tectlon Inlection I ilALTTICll HSTHOD BIIBBSB or cisis 6 5 B1ISB at 18-0.6 ag/nl b) 18-t.D ag/nl a) «ot given b) lot glTen •Eat \| GEIER1L IlFORHaTIOl J 1 a) tat applicable f at after 5 sg/kg IT. < subjects b\| tot applicable I t) Ifter 5 nqAa * 2.5 hr IT of 100 j ng/hr thiaaine, * snblects j Bange of leans, 0.05 and «,0 hr. I Beans significantly different after 6 1 tin 1 I 20-27 yr olds 1 1 Rild to noderate risnal synptons t lasting 5-10 nin 1 1 rtires; mva HTESJCTIOJI; BIOOD r »L«SB»: 08111; COWPMlTXTE 1 ITliaHTIOWS; IDOLT5 1 a\| 72.4 t or - 3.3? I a\| 0-1.5 hr excretions after 5 eg/kg b> 38.2 * or - 9. Of I IT, 5 snblects. 97.0 * or - 1.0^ by 1 6 br 1 bt 0-1.5 br excretions after 5 ng/kg 1 « 2.5 hr IT of 100 ng/hr thiaine. « 1 subjects. 75.9 or - «.6X by « hr 1 1} and b\| significantly different, P 1 < 0.001 in 0-1.5 hr excretions and t> 1 < 0.01 in 0-6 hr excretionsi 1 1 20-27 ft olds 1 1 Rild to noderate Tisnal synptons 1 lasting 5-10 «ln 1 1 c^iGS; oias IITEBICTIOI: BLOOD 1 SIIS11: USIBE; CORPtBHTITl 1 BETEBEBCE Josselson, J. Sidell, F.R. 197« Clinical Phatnacology and Therapeutics 2(1\|;»5-100 Josselson, J. Sidell, F.B. 1978 Clinical Pharnacology and Therapeatics 2« (1\|: 95- 100 U) O ------- «. C9-H13-R2-02 HB 181.2 IISSJE - «992 Blood. Plassa »«3 Blood. Sena EXMSVRB BOOTH Ingestioa Tn-fection SETHOD 8C GC . — BOBBER or casss i 5 Biiei 2.7-18.* ng/sl - a) 700-1800 no/si bj aO-60 sg/sl RB1R lot giren " a) lot given b) Rot given Giimi iRFOBEitioR Dose. 60 sg as broaide, 31 daily flyasthenie patient. U.K. BBTTSS; 3LOOD PL1SU; BEaSOBZBEBT RtTRODS; OR1TO KIR«D09 — — — — — ^_^__ . a) Initial Icrala n) iftac 3-a kr rose. 2 ain IT of 0.35 ag/lcg «ith 0.03 ig/kg atropia. 2«-»7 yr old surgical patients »itK nonal r««al fraction. B1CCO SIBOH; DRUGS; DS05 TltBHI: BBttS tRTIPaCTTOR: STISE»t fi£7EBEHC8 DS»i900, S.C. Preatis. B.». Dchghan. . Chan, K. 1980 H«thoas and Findings in Experimental and Clinical PkacaacologT 2(21:77-82 Cronnelly, B. Miller R.D. Sheiner, L.B. 1900 Clinical Pharaacology and Tberapeatics 2B(1):78-61 Eyridoiol (8 CI) 5-hTdro«T-«-««tajl- (9 CI) CS-ill-R-03 H* 164.18. BP 1«0 C ?TCimiiln«, 2,a-diaalno-S-(3.»(5 . CK-B18-H-03 e« 290.32, DP 199-203 C TISSTJE j 1 Sil* 1 .1 Ingestion BETROD Blcroblological HOBB58 or Casss - a) « b) 8 e» S BUG! -' a) 67-177 ug/1 b) 189- 3«8 sg/1 c) 2S«-«S« ng/1 . «S»R a) 129 * or - 39 ug/1 b) 239 * or - 51 ag/1 c) 31» » or - 52 ng/1 GIRIUt IRFORRITIoi" a) < 2.5 sg C-6/day fc) 2.5-5.0 sq »-6/a«y c) > 5.0 sq B-t/day Bo effect of stage of lactation. Healtby. lactatlag 2»-«2 yr olds. ITIK; Tieilll; TXTimaS; DIMS; I ICIaTTOR IEFBBBRCB «e«t, F.O. Urfcsey. 4. 1976 Aseriean Joamtl of Clinical Ratrltion LO TISSO! - Blool, Plassa ETPOSOBE BOOTE Ingestioa kRlLTTIC4t RBTB09 BPLC ROBB3T R1RGE a) b) c) d) f) Rot Rot Rot Rot Rot Rot applicable applicable applicable applicable applicable applicable 1BII a) b) c> » e) f) 0. 0. 0. 0. 0. 0. 57 92 6* 36 10 01 vg/sl og/al «g/sl «g/sl ig/sl »g/sl (REW ?4GE\| GCRERll IRFOSfliflOR a) 0.5 »r b) 2 fcr c) « kr d) 12 he •I 2« kr ft as KE Tlaes after dose of 100 sg Rcraal sablects HICflD: BT.OOO P11SB1; OSIRE: »RTIBIOIICS: BP06SJ CORPIBITITE HAIOITIOHS; HEaSOEBWlT BETBOBS 1EFEBERCE Seinfeld, P.E. Racasleb. T.C. 1979 Journal of Ctroaatography 1«»:73-8« ------- 738-70-5 nssvt (COIfIIOB») •996 BlOOfl. plasm »997 Blood, serna »998 K«r flaia •999 orlae tiposnm BOOTB Ingestion Xngettion InqestioB I«g«stio« iJltlTICIL BRBOD , TLC Coloriietry _ HPtC mix mix inasBH or cuss i - 6 « 1 BWSB . . • 1.95-0.29 «g/«l •ot gi»«n - 0.20-2, 7 C •«/•! a) »ot applicable 1,) »ot «PP"«"« c) »ot appli SS.O ag b) 31.7 >4 c> 3.0 ag 4) 89.7 ag O.S and 2-i .r B «i»«tboprt» and 800 stlfaaetboiaxol* BLOOD IMSUBBMIT •»• 20 "/1tg ,-!.? hr after » s«lfa»«tHoMiole. 2-6 rr olfls «ith chronic serous otltis sedla. HIIBTOTICSi BIOOB SSBOB; si CSI1BPT!: ,-I.S hr after « ag/»g «ith 20 s«lfaaetboxa»le. 2-6 TT ol«s »ib chronic setoas otltis »e«la. CBXIBMI: »«ti8io«cs: MOOD SSOTB! «»« fLOID a) 0-2« hr b\| 2»-»8 hr c) \|«-72 »r) tl.es sbo« eose, Siqel, C.t. Grace. B.I. lichol. C.I. Bitchlngs, S.H. 197« Ph.r.,C«C. S3 {I): 1202- «05 Kllaek, 3-J- Bates, •• nightingale, C. l«haann, B.B. Ziemiak, J.I' Qolntillanl, B. journal of pediatrics 96(«):1087-toe9 Kliaek. J.J. Bates. T.B. •Ightlngale, C. lehaann. S.B. Zlesniak, J-». Qnintlll»ni. H. 1980 journal of Pediatrics 96 (6) s 1087-1089 einfeld, B.B. facasieb, T.C. 1979 journal of ChronatographT 1S»:73-S» 26171-2J- \|«. 257.30, BJ -«5i5B— 100 Blool. plasna 1 1 1 \ \ "CIPOSOBS BOOM" - , Imgestion \ 1 t \ \ \ l_ • IWlTTIClt " KITBOD RtdiOMttT H.C 1 1 t \ \ \ \ — iOBBBB or cisss s I I I I t I \ \ IHGB a) 31.88-19.26 ag/nl b) S.21-8.97 »g/»l c) 3.93-7.11 «g/nl 4J 1.22-2.22 «g/sl 1 1 1 1 1 1 I 1 ' a) 38.88 + or - 6.62 ug/al b) 6.72 + or - 1.W ng/sl _ «c c\| 5.26 » or - 1-2« ag/nl d) 1.75 » or - 0.37 •g/sl 1 1 1 1 1 t I \ 1 21 tl t I I 1 C 1 1 * ' * 1 1 \| t Srlatel, J. . Hlgdalof. S.H. Clostnieks. J. Cllalcal Pharaacologr and Tb«tape«tics 26 (Us 122-128 I I I t I 1 I t ------- BTrrole-2-ac«tic acid, l-sethyl-S-p-tolnoyl- (8 CI) IB-frrrole-2-aeeti.e ="« 1-stnTl-5-<«-setarlben«>n>- 2171-23-3 C15-B15-B-03 BB 257.38. B? 155-157 C (dec) TISSUE 5001 nrlne EZPOSHBE BOUTS lagestion IBilTTXCU. •IWHOD Sadiosetry nc BOBBBH or CASKS 5 B1BGI •1 24.3-5.73 ng b) 191-20 sg c) 2«.3-57.0 ng a) 32.5 or - 13.9 sg b) 216 * or - 18 sg c) »1.» * or - 13.S GiBEBii 1 1 retain os _ — — — a) Tolnetin b) Balor setabolite c) Tolsetln con 1 agates 0-2* hr excretions after 300 ng C1-labelled dose idnlnlstered as sodlvn salt Patients vith rheenatoid arthritis > 1 TT, fasted before and after dose BBBGS; »BD6 TBSSlMs JISEISES; BHZIWTOIB 1RBBITIS; • 1OTT— TBFLaBBWOBT aGXVTSj BX>OOD PIIS1U; BETIBOLITES; OBIBE BEFIBEHCJ Grindel, J.B. Blgd&lof, B.a. Blostitieks, 3. 1979 Clinical Pharnacology and Therapeatics 26 (1)t 122-128 fwtole-2-a«tic acid. 5-\|p-cl>loEOb«»»Tl)-n»-dlii«tarl- (8 «» 1«-?Trrole-2-ac«tlc acid, 5-(-ehlorobe»OTl\|-1.«-ai»«thyl- 19 CI) 33369-31-2 C15-H1«-C1-I-03 II 291.75 nssn 5002 Blood, 5003 riposora BOOTE <.,„«,. Xngestioa liiiiricaL BETBOD BPLC BW.C BUB BEX OF CISSS 2 2* iiioi i a) Bot glren b) Vet giren c) Hot gien a) Wot given b) Bot given c) Bat given Bill 1 a) 2.47 » or - 1.15 b) .2 or - 2.2* c) 7.9* « or - X.07 a) 23.16 * or - 5.87 b) »3.80 » or - 19.55 c) 83.93 * or - 26.95 GSBIBU IBTOBBKIOB O «ean peak. «* » or - 7 sin after 50 ng E) Bean peak, 57 • or - 5 nln after 100 ag c) Bean peak. SO » or - 66 sin after 200 sg Peaks significantly different, p < 0.0001. BealthT sales, scan age 2* yr. fasted > 12 hr. DB96S; BLOOD S11SB1; 1&01TSJ miGBSXCS; HBI«S a) after SO ig, 3»< as vnchanged drog ft) after 100 sg. 19.3V as nschaBged a tug c) after 200 ag. 23. M as unchanged drag 0-12 hr cnnnlatlve excretion of unchanged and coalnqated drug. BealthT sales, ne»n age 2* rr. fasted > 12 hr. taOGS: BLOOD PLaSBt; IBOITS; BEFEBEICE Bayak. S.K. »g, K.T. Gottlieb, S. Plostnleks. 0. 1980 clinical Pharaacology and Therapeutics 27 (3): 395-401 Barak, B.K. Bg, K.T. Gottlieb, S. Plostnleks, J. 19 SO Clinical Pharmacology and Therapeatics 27 C3) : 395-401 OJ OJ ------- «6-5«-2 C20-H2«-«2-02 ia 12. m. m ussnE 500 BlOOl, plasna 5005 Blood, plasna 5006 Blood, plasma 5007 urine ? 17«-173 C EX MISUSE BO TIT J Ingestion Injection Injection IB»ITTIC»I Tluoronetry ILC Tlnoronetry flBoroaetry TIC Fluor osetry BOBBER OF CiSBS 5 «) 9 b) 8 6 a» » b) 8 itIGE a) 1.6-3.6 «g/«l b) 1.5-3.7 ng/nl a) a. 3-0. 26 ng/1 b) 2.75-0. 165 «g/l Mot 4lr«n a) lot qirea 6) Bot gi»en ' »E»» a) 2.3 * or - 0.7 n ------- Salicylic acid (8 ci) Eentoic acid. 2-hydrory- (9 CI) €9—72—7 C7-II6-03 Hi 138.12. tt 157-159 C, B? about 211 C at 29 •• Eg TISSUE 5008 Biood. Plasaa 5009 Blool. Plasaa 5010 Blool. plasaa 5011 Urine BIPOSDSB BOOH Ingestion Ingestion Ingestion . Ingest ion Amnicii HBT HOD BPIC • HPtC 8PLC ec HPIC BMBsa 18 a) 7 b) 7 18 B1BGE a) 0.098-33.1 ng/nl b) 0.69S-36.5 ng/l c) 0.783-37.5 ng/sl 0-55.2 ng/sl aj 0-7» ng/1 b) 106-276 ag/1 a) Dot giren b) >ot glTsu c) Sot glrm 1 ————__ HEIR a) 21.9 ng/«l b) 22.9 og/al c) 22.7 ug/»l lot given a) lot applicable b) 1S7 »g/l al «07 or - 90.5 ag b) 393 * or - 69.3 ag e) 369 » or - 77.7 ig ?j '«« «« »9 aspiria t) Ifter aei », Bg-sallcylate c) Ifter 500 a? caoliae Bg-trisalicylate leid1* °f abOBt ^°° "* salicrli<= 0»ec 16 l>r. filial £? ?ol"t~"' « «»-« «. iissoni; loowsj BIOOD nasiut J?I«i »!;l6E««i »WI-lm»B!»T08T BFass COBPMMITB muiTMtss 0 «ai a hr after 1000 ma MlicylaalicTlic aci«. Clearance by 2 hr. Ijtlaated fro* graph. SIJ.!!01" IBBIS: WOOD H.1SB! iiilSEsics; ini-iiniBnioti IG-HTS- BI1SBBMMT BETBOBS; DOTGS 15!"S> a) lo.est a»4 highest nlaes o»er 2» hr following tngeation of a single a 9 dose. ieT«is peaked at 2 hr and , « ff511'4- Considerable indiTH.al variation, dne to "'Sand'59 U •€t»bolls" o£ P"»«» dUirliL'l,5^ •! f0110'1'" -i« aally dase of 3 g of benorylate. Bealtliy 21-67 yr oUs. nt »«-100 kg FBIBCE; IBDItS; BWOOj BIOOD PllSBi- DMGSJ II fluo HllySIS ' __ Jj «« «9« ., aspirin "«r 81 •« « ------- salicylic ei« acetate (8 CI) BensolC »eia. 2-<«cetyloxy)- (9 CH 50-TS-2 C9-B8-0 SI 180.2, IIP 5012 Blood, plana 135 C EXPOSUBB BOUIE Ingestion liunicu METHOD - OF CASES . 6 Silos - — ~ a) lot gi»en bl lot gl»«n nil a) 81 ug/el b) 76 ag/nl — "etimi HFOSBiiioB .) Bean pea* at 1 hr. 1200 »g aspirin t\ Bean peak at 2 hr. 1200 «g * 500 sg naproxen IstUated from graph. „„-__,. Irea-«naer-the-cnr»e not different •it* naproxen. P>0.05. Healthy 23-«fl tr «!««. fastefl oiexolqht. rsnesj Datre nweaicTioi: MM-iin»Bawosi »GHTS: »BJt«: flCIS; BtOOD PIIS81: CO«P»S«1VB IfllVkTXOIS — MrtBEBCS . — . — • Segre. !.J. Chaplin. B. rocckielli. I. Hankel. B. SeTelias. B. 197* Clinical Pharnacology ani therapeutics 15<«»8i7»-379 Salicylic acia, ionf1-1 (8 CI) Eentoic acid, 2-hydroxy-. ion(l-) (9 CI> (T1U S3-36-S cl~*?°?. .., ,rn ^ «n .hnnt 211 C at 20 aa Bg HI 13«.t2, « TISSBS 5013 «lood, plan« 50 1« Blool, plasaa S01S Blood. plaava p 15V159 C, BP a EIPOSME SOBTB Tnfetion Invest ion Boat zii •«• »l «« •• allirTXCll NZTBOB . - ColoclMtrr loissa OF C1SSS 2 6 BUGS ~" a} »ot applicable b) lot applicable 10»-157 «4/al • (BUT iili a) 25.7 ng/100 »1 b) IS. 7 ng/100 «1 lot given «aSI) — SEBBB1L IBFOSBlTICra a\| «born, ««bllical cord rein U birt" after «.S -MO rcaser, D.G. London. T.B. iTens, B.P. Sntherland, E.B. 1980 Clinical Pharnacology and Therapentics 27{2):16S-1«9 ------- Salicylic «cld. load-) (9 CI) Beazoie acid, 2-hydroxy-, ion(l-) (9 CI\| (MI) 63-36-5 CT-B5-03 it 138.12. HP 157-159 C, BP abovt 211 C at 20 » Bg (COBTMDBD) TISSOB 5016 Blood, plasma 5017 Blood, seram 5018 Blood. senm 5019 Blood, sera* ••020 BlooJ, seram EXPOSURE SODTE Ingestion . IngestiOB Ingestion iBgestiom Ingest Ian imtTICII HBTBOD rlaorometry colorlietry riaorosetry BBBBJB or cists a) 1 b) 1 C) 1 d) 6 «> 6 12 7 20 9 81BQE a) 9-0.2 og/al b) 20-2 ug/Bl c) 28-7.5 ag/al d) 28.8-73.2 ag/ml e) 54-120 ag/ml a) 7.13-34.6 ag/100 ml b) 0.582-6.06 ag/100 ml Bot given 4.4-33.0 ag/100 ml _ . a) 10-26 mg/1 b) 29-58 ag/1 c) 106-181 ag/1 d) 122-236 ag/1 «) 175-286 sg/1 f) 215-292 ag/1 (BEIT HE»S a) Bot applicable b) Bot applicable c) Bot applicable d) 40.1 » or - 17.3 ug/al e) 77 + or - 24 ug/al _ .... a) 19.67 » or - 7.62 •g/100 al b) 2.73 * or - 1.69 •g/100 ml - 0.53 + or - 0.08 mmoles/1 14.47 mg/1 00 al a) 15.44 ag/1 b) 44.56 ag/1 c) 147.89 ag/1 3) 189.56 ag/1 e) 243.78 ag/1 f) 254.50 ag/1 P«GI) 6E1ZB1L IBFOSUnOB a) 0.5 aad 6 hr after 15 al dose b) 2 and 9 ht after 30 ml dose. Initial leasorvmeat, 11 ug/al at 0.5 e) 3 and 9 hr f ter 60 ml dose. Taltial aeasareeat. 12 ag/sl at 0.5 d) 1.9 hr after «0 ml (peak meaB level) e) Peak level after 60 al/6 hr for 5 doses 8.77 sg sallcyelie acid/al Bealthy 28-38 yr olds, »t 50-82 kg • DOITS; BBIBIi BLOOB TUSB1; DSOGS; IBatBtStCS ) Total, correlatioa with saliva levels, r-0.708 t) Free, correlation «lth saliva levels, r-0.944 Tise-averaged steady-state levels. nsval dose 8C aqykg/day. 7-17 yr olds with rheamatoid arthritis. I»B« TBVK1PT; 1MIGESICS; SatlTI; BIOOD swan; CHUBSSB: B.MBSMOIB 1BIBBI1IS: Dm.SBS; COMmirfB miOMIOBS; ILIIBOIS; HBlSBBBnBIT flITBODS Beaa peak at 0.5 hr after 900 ag plus one 60- eg sustained release tablet of phenytoin. 27.4* redaction of phenytoia IB 2 hr. Bcalthy 23-36 yr olds. »t 50-80 kg. ttOSS; DSB6 TBTEBkCTIOB; BIOOD SfBO»: »t BITS; sum; aBTicoBvoisirrs; mtGEStcs: IBTIPTBETICS: m ZtallBt; HEI1BOLISB Ifter 5 days on 50 sg/kg/day buffered acptriB in 5 doses. Bheamatold arthritis patients, ages 20-86 yr. D10CS; BflnRlTOID lETHHITIS; BIOOB sisoa: nini; jBBttSs BISEJSIS: fllTlBOlISH; BITlBOtlTSS a) 0.66 B4/kg/hr b) 1.0 mg/kg/hr c) 1.8 ag/kg/hr C) 2.1 eg/kq/hr e) 2.7 ag/kg/hr f) 3.0 ag/kg/hr, 6 snb-lects Steady state levels Scalthy 25-40 yr olds, OB no aedlcation >2 wk and ao sallcylates '3 VIE* rtTJSS; HHTI-HriilHAtOBT 1GIBTS; 1B116ESICS; BIOOD PUStl: PMTEIBS- OSI«E: C01>P>BITITE ITHLDtTlOlCS: BITlBOtlSHj 1D01TS - J SIPEBEUCE reldaan, S. Chen. S.-l. Pickering. L.E. Cleary. T.G. Ericsson, C.D. Raise. B. 1931 Clinical Pharmacology and Therapeaties 29 (8)5 7 88-792 Levy, G. Procknal, J.I. Olafs. B. 1980 Clinical Pharmacology and Therapeaties 27 (5) j 6 19-627 Pazton, J.B. 1980 Clinical Pharmacology amd Therapeaties 27(2):170-178 Gapta. B. Sarklssiaa. I. Paalns, B.e. 1975 Clinical Pharmacology aad Therapeaties 18 (3): 3 50-355 rarst. D.E. Tozer, T.I. Relmon, K.L. 1979 Clinical Pharmacology «md Therapeaties 26(3):380-389 U) -J ------- (3-36-5 L7-B5-UJ 10 138.12. It TISSOB 5021 Salira 5022 Urine 5023 Or ioe 502* Drine 5025 Brine 157-159 C. BP al "EHOSTOB «o55F Ingestioa Ingestion Ingestion Ingestion Ingestion oat 211 C at 20 •• I 1I1LITIC11 HETBO* Color iietry Coloriaetry coloclsetcy _ tg BUSBIB or cases 12 2 - - 20 9 a) C b) 6 (com ~ Hies O.M6-3.58 sg/100 nl 5«0.7-603.2 ag 1.28-1.86 sgAg/ac 92.4-105-8* of dose _— -^— ^— • ~ a) 87.0-103.9X b) 56.0-94.1* »OBD> BBlt 1.67* or - 1-03 mg/100 il 581.95 sg 1.51 ag/kg/br 96.83* of dose a) 95 » or - «.« b) 77.2 * or - 13.0* Iia«-a»eraged steady state levels. nsnal dose 8C sq/kg/day 7-17 yr olds with rheaaatoid arthritis. BIOOBTSBBOB;'cHItBB««S »""!!??) MIBBITIS: BISZiSBS; COHPlBlTItB !T»HI1TM!IS: ItlHOIS; WaSOMSWT BZTHO9S ticretia in 2»-hr orlaes. after 300 •g buffered aspirin. Talues deternlaed by ne» aethod coapare to >6«.0-a53.9 ag. deterained by often-ased colorinetric aethod. aealtliy 22 and 24 yr olis. HBTI-TWlfcNRlTOTTT ACSBTS «-ret:ion of total salicylic acid afSr 5 da?s on 50 .gAl/«»f battered asririn in 5 doses. Boderately correlated »ith »eraa le»els, r-0.50. Bhenaatoid arthritis patients, ages 20-<« yr. BMGS: BBW!I»TOI» aBTBBITIS: BIOOD sci>Qfl; ?Blr.; ADOLTS; DISBASSS; imBOttSB: BfTlBOlITSS Daily ariae reco»ery. neans alter 1.0. 1.8. 2.1, 2.7. 3.0. and ».0 sg/kg/hr at steady state. BHlthr 2^-«0 yr olis, on no abdication >2 -k and «o salicylates tsosst m-i-nriasHiTOH »<•«;;: naiGEStcs: EIOOD w";,""?115- mf: cospaMTirt entMTiois; BITIB01ISB: aBDXTS — — * ,1 Total oatsat after 60 ml dose b{ Total oatrnt after 60 si erery 6 br for fiTe doses 6.77 aq salicyclic acid/al Bealthy 28-36 Tr olds, «t 50-82 tg IIUITS: im««: BIOOB Piassa: ososs: »1«16ISTCS ~ BZmEBCE leyy, G. Procknal. J.- Olafs, B. pachaan, !•••• 1980 Clinical Pharaacology and Therapeutics 27 (5) -.6 19-627 — — chioa, >.l. oayenelakve, I. 197» joarnal of Pharnaceatical Sciences 63(»):630-632 Gupta, I. Sarkissia. !- Paulas, H.B. 1975 Clinical Pharaacology and Therapeutics 18(3)t350-355 Tnrst, D.I. Toier. T.». Kelson. K.L. 1979 Clinical pharaacology and Therapeatics 26(31:390-389 reldaan. S. Chen, S.-l. Pickering, l-K- cleary. '-G. Bricsson. C.P. Boise. B. 19S1 Clinical Pharaacology and Therapeatics 29(6)5788-792 CO oo ------- Salicylic acid. -aaiao- (« ci) Erazoic acid. «-anltto-2-avdroxv- (9 Cl) €_"4i^6 C7-B7-1-03 81 153.13. IP 150-151 C IISSQB 5026 Blood, plaaia 5027 Uxine Ingestios Ingest ion BPTB08 •OB BIB OF CUES 12 - 12 B11GE a) »-»9.98 ug/al b) 155.M-* ug/il c) 121.09-5 ng/sl d) 139.51-6 ag/«l - a) lot given b) lot given c) lot given d) Rot given 1111 a) lot applicable 1) Rot applicable c) Rot applicable d) Rot applicable a) 77.2* of dose (3.1 9) b) 92.8% of dose (3.7 q) c) 98.55 of dose (3.9 g) d) 98.21 of dose (3.9 g) SEIIMI nrosBiTioi a) 0.25 and 3.5* hr after aaiaosalicylic acid. 21 ag/al at S hi. b) 0.83 and 6 hr after la aninosalicylate. 57 «g/al at 0.25 hr cj 1. 10 and 6 hr after K aalaosalicylate. 32 aq/nl at 0.25 hr 3) 1.02 and £ hr after Ca aninosalicylate. 30 «g/»l at 0.25 hr Corrected to 70 leg vt and * g free-acid-eqaivaleat dose. lealthy volunteers, no drags or alcohol for 3 «k, fasted overnight before and S hr after dose. DnBS{ CO-P1B1TIT! mint-IMS; BLOOD EUSHl; UBTM a) BlnosalicyUc acid b) la aninosalieylate c) K-asinosalicylate d) Ca-aiinosalieylate 2* hr cnsalative excretions after * g doses 1» forns In a)-«). 52.3-56.7* of dote excreted In aeetylated £or«. Healthy volunteers, no drags or alcohol for 3 «. fasted overnight cefore and 5 hr after dose. WOSS; C08P1SIHVE STMnwiORS: BlOOfl tEFEBElCE Ran, S.a. Pentlkainen, P.J. azarnoff. D.I. 197 Journal of Pharnacvntical Sciences 63(5):709-711 Van, S.3. Peatikainen, P.J. azarnoff, a.i. Journal of Pharuceatical Sciences CO VO Salicylic acid. 5-( (p-(2-pTriaTlsulfaaoTl) pheayl) azo>- (SCI) 155^5^1** 2-n7a«I-5-({«-((2-PjridiiijlasinoJsnlfonTl)phenjlJa»o)- (9 Cl) cie-m«-i«-os-s BI 398.39, BP 20-25 C (decoap) 1ISSO! 5028 lenlotic fluid JIPOSOSI BODTB Ingest ion IHalTTICJt RCTBOD - - BTIBBI8 or CASES 5 BUGS -' a) lot given b) lot given c) tot given d) lot given e) lot given ------- ^sa^^ " il 398.39: « "0-2« C taecosp) (COITMOM) \| II3SOK 5029 Blool, fetal 5030 Blood. sena 5031 lilk "'mosrai BOTJM ' Xnqestion Xngestios Xngestion - IHLTTICIL or C»SBS 5 5 3 - ~ IHeT" b) lot gian c) wet given 4) Sot given e) <0.5 ng/sl a\| lot given b) lot gives c) »ot given 8) lot given e) <0.5 ng/sl a) Wot given b) tot given c) Cot given a} »ot given BEftl a) a. 2 * or - 3.0 b) 11.0 * or - ».0 c) «.9 » or - 1.8 4) 0.6 * or - O.S ag/sl e) lot applicable a) 7.3 » or - «.0 b) 10.6 « or - «•* o) 3.T » or - 2.» ag/sl . , 1) 0.5 * or - 0.3 e) Hot applicable a) 2.7 » or - 1.8 ag/sl b) 10.3 » or - 1.6 c) l.» » or - 0.7 Bg/m _ — • a) Salphasalaxine b) Total salthapyriaiB* e\| icetylatea snlphaprriaise 3) acetylatea svlphapTriaine glocaroniae «1 Total S-aniaosalicrlic acia Reasarea at aeliverr- »ose. 0.5 g. pwerperiav. Blooa froa OBbilical cocas. Salients with nlceratlve colitis who tscac* preonaBt while oa therapy. HHIOTTC rtniD: BIOOB SBEOH: eistsoimisTiMi STSTBBI »J"» _. giBXlTC! COBBS »S96 IHSS1M8 BB06S; iRlBOLIS": BRIB01OTS: MBCntCt; I1CMTIOW a) salphasalazin b) Total salphaprriaine e) actrlatea sslphaprriaine a) acetvlateJ s«lphapTriaine 2)U»t™"-ani«o»UcTUc acia •easirea at aelirerT. Oose. 0.5 g. •i/aav anriag preanancr ana EierperitiB. Fatleats with olcerative colitis Bho bacaae pregnant aorinq therarr. HSIOTIC FIOID: BIOOB SEBBSs SISTFOIWtfSIIMt STSKB: HXU: nazxiicii coFD: DSBS iBBHaK; DBWS; llama'' "ErlBOlIT1!Si P"CT* a) SBlphasalaiine b) Total salphapTriaUe et ieetflatea s«lphapTrtai»« a) acetrlatea snlphaprriaiM C.5 i »«/aar aaring pregnancy »•* paerperias. patients »lth olceratit* colitis who heeane pregnant while on therapy. UIIOTIC ?l«Ds BWOO SZ80II: sSrSrs.s'.sniWS^Dio.i, aiTiBoixsii! BR»BOIITS: PBSGWUCT: t»CT»TIO« BZTVBBld Troelove, S.C. British Beflical Joornal 2{620«):1S53 nan, I.X.I. Troelove, S.C. 1979 British Beaical Journal 2(«20»):1551 Khaa. l.I.A. Trnelove. S.C. 1979 British Bedical Journal 2(620»):15S3 -_ ""'" ------- frarteine (8 CI) 7.1«-aetkaBO-2I.CI-aipyrido(1.2-a:t'.2<-e) (t.S)diazocice. lodecahydro-, (7S-(7alpha,7aalpha.14alpha. 14abeta))- (9 CI) 90-39-1 C15-826-12 Bf 23.37. IP 173 C at 8 an Bg US-HE 5033 Brine mason BOOTS -~«" AI1LTTIC1L HSIBOD GC BOSSES or CASES 1 BAM: a) lot applicable b) lot applicable BSAB __^____________— __^-^-_ a) 85% of dose (170 aa) b) < « of dose (< 2 aq) GtllSIL IIFOBBATIOI Is sparteiae b) As 2- and 5- denydrosparteiBe 0-2* br emulative excretion after 200 Bq as salfate 70 kq, vaite sale pbenotyped as "poor setabolizer" according to capacity to t-hydroxylate aebriso-aine and sparteine. C?OS3; IB-lBCLIsa; BTriBOlIIES; 01IK; COSPltltlVB ETllaKIOIS: SID1TITK; BTMOtlCS! AMIPICMICS; AHIETPEBTEISXTE IGMfS; BEFEBEICB Inaba, 1. Often, S.T. Fa Ion, i. 1980 Clinical Pharmacology aad Therapeatics 27 (4) : 57-549 S»lfa»ila»ia«, H1)-(3.«-di«ethTl-5-isoiaiolTl)- J8 CI) z«Bzm«sulfcuiid«, B-a.iBo-1-(3,»-di»thrl-Vlso«axolTl) - 19 CI) 127-89-5 C11-H13-13-03-S II 267.30. IP 19 C (also reported 195-198 C. 192-195 C) iissas 5033 a ilk Birosm: aom Tl^eation llainiCAl HRBOB BUN BBS OF CASES 6 1188 - a) lot gives b) lot given c) lot given d) Hot given Mil a) 18 + or - 8.4 >g b) 0.45 » or - 0.21% c) 22.8 + or - 11.51! d) 77.1 t or - 11.5X GBI1SU IIFOilUTItm i) Total salfisoxazole b) t of laternal dose c) of total svlfisoxazole recovered as snlfisoxazole 3) * at total snlfisoiazole recovered as >-acetvl salfisoxazole tos« 1.0 q every 6 hr for 2 br. 48 III collection period Caucasians, ages 19-27 yr EOlKHHfllD'S; BI01CCD1DIATXOI; HCMtlOl; KT1BOUTK; KAISAS; IBUUS; ^IH; DKOSS . 5IFEHEHCE Kauffsaa. B.E. O'Brien. C. Gilford. P. 1980 Pediatrics 97 (5): 839-841 Snlfaailaiide. ltt)-(4.6-ai»ethyl-2-PTri«iaiBrl)- (8 CI) Bea«nes«lfooaai4e, 4-a»ino-I-(«,«-Si«thTl-2-PTri»iaiiiyl)- (9 CI) 178-1T9 C, 198-199 C. 205-207 C) C12-B14-14-02-S Si 718.32. BS 17* C (also reported: \| TISSUE 1 1 1 1 1 503* Blood. plassa iiposms BOUTS i Ingest ion »»nmcAi !!Z?SOI BOBBER cr CASES 5 BUG: a) 30.860.4 qg/»l b) 73.3-122.5 ug/sl (IEXT Bill a> 41.2fi 4 or - 11.53 »q/»l b) 103.84 » or - 11.58 ag/al ._ . .. PACE) GE«iBL iironnATioi a) Peaks, 1-3 lir after 10 igYkq. b) leaks. 1-6.6 hr after 40 aq/kq. t«altby 2?-3« rt olds. »t 7»-96 kg, fasted 12 hr before to 2 kr after dose. 01IIE; BLOOD PLKSH; DB7BS; miAaoiisa: IETABOIITSS BEFESBItCE da Soaicb. ?. lalka, D. Slaughter. E. Elvin. A.T. HcLeaa. A.J. 1979 clinical Pharaacology and Therapeutics 25(2):172-193 ------- Snlfanilasidc, H<1)-{.6-diaethyl-2-pyrini ------- Silranilanidc, «<1\|- C10-B11-I3-03-S Bl 253.31. HP 187 C - (9 5039 Blood, plasna 500 Blood, eer» 501 Far fluid Ingestlon ____. __ Ingestion BETHOD TLC coloriietry HWC BPIC OF C1SBS 1 . 7 7 BUGS -- 26.33-1.* ng/nl Hot given , 2.81-25.7 Og/ll BE1 Mot given »».6 « or - 22 ng/sl 8.21 or - 7.0 ug/nl SE1IUL IIFOX8HIOI 0.5 and 25 hr after 160 nq ttlMtnoprl* and 800 ng smtaiettoxazole. CBHGS; 11TIBIOIICS; BLOOD PL1SH1- BMSBSEHIT HETBOSS — — — __ ._ , T^ olds vith chronic serovs otltis sedla. BIOOB SMDB; F»B THUD* *' " ' ' ~ ' 2tlti' Ol4s it!l CBronic s««'os — _rt » iHrECTIOHj CBUDBZX j BEFBBBICE Sigel. C.H. Grace. S.s. vienol, C.». Hltchings. G.B. 197* Jonrnal of Phariaceatical Sciences 63 (8): 120 2-1205 Kliiek, J.J. Bates, T.B. nightingale, C. letnann. ».B. zieniak, J.I. Qnintiliani, P. 1980 Jonrnal of Pediatrics 96 («) :1087-10B9 Klinek, J.J. Bates, T.B. Hlgntlngale. C. lehninn. «.B. zienniak, J.I. fluintillani, P. 1980 Joarnal of Pediatrics 96 (6): 1087-1089 £il«»silaiid€. I(1)-2-pTridrl- IB CI\| a-aniBO-B-2-pyridinTl- (9 CI) OJ C11-B11-I3-02-S El 29.29. HP 191-193 C 502 Blood, sera* BX?BOD IDBBEB OF CiSSS 15 ~~ B1IGE 0.8—28.6 vg/el BUI 18.17 ng/sl 1 s e at a< 1 D 1] r« CI CI SHIBJL IIF01MTIOI and 9 hr after 22-68 ng/a snlfasalaziiic in doses divided jllY 2t or «/lay. Inclodes trlat«a and glacuronidized netabalites. 10 rapH acet7lators, 12 raT»id hydroiylators. yr olds, «lth Crohn disease or olcerative colitis. ill b«t one in coaplete clinical r»ls«ion after >1 vk Uerapy. ; onus IBEBIW; umBoiHEss CETIDSEl; ?LCOD SntBB; BrUSOLISH BEFE5EICE Goldstein, p.p. llpers, D.B. Keating, J.p. 1979 Joatnal of Pediatrics 95«):638-60 ------- .. 3.7-di.Tdro-3.7-dl.eth,l- f* t3-67-0 Si~ieo!l7?2B* 357 C. BP 290 C (Bubli.es) 1ISSOI 503 filooJ, Flaasa 50M Rilk 504 S SlllTI IIPOSOBE aOBTE Ingest ion Ingest ion Ingestion Iliimcit HETHOD BPIC BPLC BPLC »OHBEB OT CiSIS 6 • < 6 \| B»GB ».5-7.8 sg/1 3.7-7.5 ag/1 a. 5-8. 2 ng/1 5.7 »g/l 5.3 «g/l 5.7 sg/1 GB1IS1L HFOTBatltH Hter 113 ------- ineopbviiine (a cq 1F-Puriae-2,S-dioiM, 3.7-aibvdro-1.3-aisethjl- (9 C7-B8-B4-02 El 180.17, BE 270-27 C (COBTIBHED) 5047 Blooa. plasaa 5048 Blood, plasaa 5049 Blooa. plasaa 5050 Blool. plasaa Ingestion IngestiOB Ingestlon In lection BETBOO BPLC BS1C GC BPLC or cisss 14 4 12 1 a) 9.3-17.1 ng/1 b) 4.3-8.9 ag/1 c) 13.3-51.3 ng/1 4) 7.9-20.4 ag/1 a) 0-135 ng/nl b) 45-110 ng/nl ct 60-165 ng/Bl d\| 70-195 ng/al e) 95-185 nf/nl g) 125-190 ng/al f) 145-195 ng/Bl h) 45-160 a) 9.7-4.9 ng/sl b) 21.1-11.6 ng/al a) 8.25-0.6 ng/al b) 17.5-0.85 ng/Bl ct 12.0-0.50 ng/al dl 17-0.7 ug/nl BUI at 12.8 ag/1 b) 6.5 ag/1 ct 25.2 ng/1 at 13.2 ng/1 at 49 » or - 30 ng/nl b) 79 * or - 15 ag/al c) 106 » or - 22 nq/nl d) 118 * or - 27 ng/Bl e\| 133 * or - 19 nq/al ft 16314 ng/nl g\| 173 » or - 11 ng/al hi 99 » or - 6 ng/al (S.E.I a\| «ot giv«a b\| Bot given at lot given b) Bot given c) Bot given at Bot given SlIMll XBrOBSmOB at Peaks after 5.6 g/kg. total body vt basis It Peaks after 5«6 ng/kg. ioeal body •t basis c\| Stealy states, 0.9 ag/kg/hr. total tody «t basis at steal? states. 0.9 ng/kg/hc. Heal Ccee as aainophvlliae. Cbese 23-5H yr olds tBtJSS; BLOOD PLaSHI; TBIOPBtltlBIS: CCBPIB1TIYE PfltOSTIOIS ~ a\| Ifter O.«i hr I) ifter 1 hr c\| Ifter 1.S hE at Ifter 2 hr e\| Ifter 3 hr fl Ifter 5 hr 9) Ifter 7.5 hr h\| Ifter 24 hr relieving 300 ng aose of caffeine. volunteers. Canada C1BIDI; ID01TS: BIOOD PIISB1; mBETTCS: DEOGS; ROSCLB BELITJUTS; CCB.PM1TIVI ETILOITIOBS: BCTIBOUTBS a\| Beaas after 225 ng/12 hr t) Beaas after 450 ag/12 hr Administered as aalnophvlline, sustained-release capsale Healthy 20-33 yr oias, one snoker. Bo caffeine-containing beverages for 24 hr ana tasted overnight before etndy. ion dose effects: nild headaches. anxiety, and palpitations. High aose effects: naisea, voaltiog, insoania. aaiiety, headache. Syaptoas nore likely at plasna levels of >1? o^/al. tlHTBD KIBG9CB: IDOLTS; BIOOD Pl»S»I- MOGS a\| Control trial (no antibiotic) b\| Orng tetracycline c) tmg » etnhronycin 4) Drug * cephalexln > nln ana 2» hr post-infusion. latibioUcs given as loading dose of •!00 no DIBS 250 nq/6 hr, oral. « nin IV of 5 nq/kq aninopliTliine after 4th antibiotic dese. flealthy 21 tc 33 vr oias. no lanthine-eontalnlnq foods t beverages t store and after dose. Tachycardia and slid treanloasness. tSOGS; 1BTISIOTICS: TBlOPHTtLIHSS: E1COD PllSBD; 1 DOITS (KIT P»SE) 8IWBEBC3 Gal. P. Jnsko, B.J. Tnrchak. i.g. Franklin. B.I. 1978 Clinical Phamacology and Therapeutics 23 (4) : 438-«44 Sved, S. Bossle, B.D. BcGilveray, i.j. 1976 Pesearcb Conaaoications in Chenlcal Pathology and Pharaacology 13 (2t: 15-192 Trenbath. ?.P. Boobis. S.». 1979 Clinical Pharmacology and Therapeutics 26(51:654-659 Pfeifer, H.J. ereenblatt, D.J. Frie4aan. p. 1979 Clinical Pharaacology and Therapeutics 26 (It : 36-40 Ui ------- theophylline (9 CI) 1B-Puri.n«-2,6-dione 5E-S5-9 C7-BS-I4-O2 II 180.11, »B 270-274 C 3.7-dihydro-l,3-ainethyl- (9 (CORIROED) T m' TISSUE 5051 Blood. plasma 5052 Blood, tlasaa Hood, plasna S05» Blood, serai KXPOSOKS SOOTI Ingest ion Ingest ion - Infection nunicii BETHOC BPLC HOMES OF C1SES 18 1 ~" JMGB a) 0-14.9 «g/»l b) 0-12.0 ug/nl c) 1.5-14.3 «g/nl 1) 1.5-14.0 «g/nl «) 7.7-11.6 ng/nl f) 6.5-11-9 ug/nl a) lot applicable b) 120-31 mg/1 a) 0-24.0 ng/1 b) 3.9-17.0 ug/nl c) 8.1-35.2 ag/ml a) 6.3 * or - 4.7 uq/ml b) 6. 3 + or - «.S ag/»l c) 10.2 * or - ».* ag/ml 1) 9.2 * or - «.3 ag/»l e) 9.S » or - 1.1 na/al f) d.8 + or - 1.9 ag/il a) 16 ig/1 b) Rot given a) 6.7 ag/al b) 8. 3 ag/il c) 15.2 ug/«l a) Tablet, 0.5 hr t) Elixir, 0.5 hr e) Tablet, 1 hr 6} Eliiir, 1 hr e) Tablet, 0 hr f) Eliiir, » hr I lies after 375 >g dose in fora stated patients vith chronic obstrgctiTe long disease, lean age 59.4 re. IDEtralla Significant tronchodilation JDStSltli; &EOITS; DISEJSES; BLOOD PtaSHl: BUTBETICS: DBOGS; nSCS.1 RIUT11TS; CCUPiSlTITE BT»LB»TIOKS : E!S«B»TOFI ETSTEI a) 16 hr after 1.S75 g as sustained-release tablet t) 0 and 170 ain of charcoal heioperfnsion 15 yr old, 43 kg overdose patient iTpotension and tachycardia after 10 ir, then cardiorespiratory arrest. icldosls, hypokaleaia, cardiac arrhTthaias, tachycardia after resascitation. aspiration pnennonia and acute renal failure after teaoperfnsio. IEWJPBTLL1HES; L»»IGE; HTJCTE»SIOI; BHLT1 1»?»StS: DSOG 1BOSEJ OHTED KISBO'!: 91CCD PlaSHi; DFOSS BeTiew Chronic dose torieity: anoreria, nausea, voaiting, abdoninal disconfoct. Serious toaieity (cerebral seiznres, oardiac arrtrthliss cr respiratory or cardiac arr«st) is infrequent. mm: TBEOPHTLLIIES; DISE.SES a) Tine 0 t) Change following 6.0 ng/kg IT aninophylline e) Peak levels isthnatie 0.5 to 20.9 yr olds, on 2.7-9.S no/kg oral tbeophylline lailting, trenors III YORK: CHIIOSI: BLOOD SIB01I; DPBG niPTl THfOPHTLUMS BEfEBEKCE Hartnett, B.J.S. Darlin, G.E. Grahaa, G. 1974 nedical Joarn&l of lastralia 1 (14) ;532-53S Jefferys. D.B. Baper, S.B. Helliwell, B. Berry, St. 3. Crone, ?. 1980 British Redical Journal 280(6224) :1167 Piafsky, K.!!. Ogilrie, B.I. 1975 Rev England Jonrnal of eeflicine 292(23) :1218-1222 canavan, J. V. Ellerstein, B. S. Soil IT an. T.D. 1980 Journal of Pediatrics 97(2) :3C1-303 (HIT PUGS) ------- Iheophylline (8 ci) ' 3'7-illTa™-1.3-"»«thyl- f9 en C7-H8-1»-02 •I 180.17, HP 270-274 C 5055 Blood, sera* 5056 Blood, sera* S057 Blood, sera* 5058 Blood, sera* lagestion Ingestion - VRHOD IPLC CC Enzyne Inmnoascay HPLC (COITIlUfD) ttUSBfB OF CASES 20 21 20 B1VGE a) not given b) Sot given a) 1.7-26.2 ng/1 b) 1.7-26.6 ng/1 a) 0-44 unoles/1 b) 20-65 aaoles/1 c) 27-70 aacles/1 6.7-23.5 aval Bill a) 5.92 * or - 2.» •g/i b) 2.52 * or - 0.96 a) 9.27 » or - 6.2 •q/1 b) 9.26 * or - 6.2 • ------- 3.7-ailTdro-1.3-«i.eth,l- (9 en •8-55-9 rl 180.17, H TISSUE 5059 Blood, sens 5060 Blood, seraa 501 eiooi, serai 5062 carebrasp iBal/TSBt ricslar flail P 270-27 C ~ EISOSUBB 80ME lBlectlo» lBgetioD Injection "~»B_1TTIC1L KTBOD HPLC snc ac HPIC IDS BBS OF CISBS 4) « b) 7 14 15 S — (C01TJ "~ iiicl a) 0-12. BO./B! b) 0-8.? BO/sl a) 11.5-0.5 B«/sl b) 15. 1-0. « «9/»l 3.9-19.5 a«/Bl 4) let giTen b) lot o,i«n • IEDI sir "~ . — a) Mot giTen b) Hot gi»en . . ____ a) lot gireft b) Hot gl»«» 11.0 * or - 5.1 «J/nl a) 5. 25 « or - 3.5 b) 2.16 » or - 1.06 •1/1 -GHSB11 nWiiWIOI a) 0 «B« 20 tin .ftet lOBdiiiq lose of 6.0 •g/fc9 (20 •!» I»I »«a then 0.9 .,/kq/hr for 100 B!B. SteaflT state of 11 B<\|/il at «0-2«0 Bin b) 0 »»« 20 BiB after loading lose of t ma/Ya (20 BiB IT) aB< theB ,.I!t«aBCe dose of 0..5 .,/lc,/hr to »chl«»8 s«rn« letel of 5 n^/Jl- Stea«T at«»« of 7 •O'"1 •' 3 •ealthT 22-33 yr olds, fasted 8-12 hr before, aad duriB? BtqlT- 080SS; TBZOPHmiKS: B100D SfSOH: HEOHS a) Basse of B«aBS, I-2™ 2* hr after 300 Bg as aonalcotolic BBiBOpirUl"* "olrtioj. ^I;lt}»1 .easoreaent, 1.8 « ------- Mtkn- C9 ;«-S5-9 C7-B8-M-02 Ct 180.17. « 270-27* C (COITI19BO) USSM 503 9riB nnsaHS BORE lBl«CtiOB AlLLYTlClt RET BOD BaAlOeMtCT cc •BflBBB or C»SBS 3 I1BGE a) a.7-10.7* b) 5.3-11. 2* c) 16.0-18.M d) 19.0-23.2* e) 26.1-33.2? f) 33.9-38.3* q) 13.1-25.3* k) 10.6 20.5? 1 • a) 7.3* 1 a) TkeopkylllBe. asaal diet b) 9.0* 1 b) TkeopkvlliM. BethTlaatkine-rEe« 2 2UT 1 c\| 3-SetkTliaatkiae {Betabolite) , e) 29. « 1 !•««! diet fi 35.9 I d) 3-»et»Tl«atiia« (Betabolite). a) 18.3* 1 •«thTl»aithi««-fr«e diet k) 17.7* 1 e) 1.3-DiBetkYlacic acid 1 (setabolUe) . eseal diet 1 f\| 1.3-BlBetkTluic acid 1 (aetabolitel, B«tkTl««»tkiBe-fEee 1 diet 1 B»al diet 1 k) 1-HethTl»tie acid (Betabolite) , 1 a ------- tl,lo»«thene-2-s«lfosanide, I.I- ------- «boc«rari»e C37-BM-I2-CC •1 609.80 "I (T.ij Tf'12f-ai»««'T-«.«'-«i««t«r-2.2.,2.-trl-tbIl- 19 CD TISSUE 5967 Blood. Flassa BIPOSOBB BOOTI Injection — _____ BETBOD — in BOSSES OF CASKS 10 B1B6B •) 5-6 ag/ml b) 0.45-0.95 aa/Bl e) «-«.« «g,sl 4) 0.5-1.5 ag/Bl Bill a) lot given b) lot glTen c) Mot given d) Rot given " SSBIBII isTomnoi ~ •1 tornals. 3 lit t) local. 120 Bin c) Imal f« Hares. 3 sin Jl Benal failares. 120 tin J«?f ^J'J* aos" of °'5 "^' "• I8tl»t«9 fro« gcapki. Data alao 9iT«» foe 0.3 iq/tg dose. !.J?1:.'lCtllr* "C^'r patt««ts «2.? J'lH**** wltt <w>»ie «»«-«ta^ r««al fallira, prior to !ciaBeT traapu>t. IciporatT patalyaU correlated »ith flr«9 IT«I. Half laitnl effect at 0.3i . ,t - 0.03 nq/il. jsnss; one Tnnm: gnscis !S«lnS' BIOOD 1»»»l KIBKI CISMSIS; COWIBITIT8 ET»lniTIO»S BIFEBHCE Sketaer. l.B. Stanskl. D.B. Toieh. s. Hiller. S.D. Haa, J. 1979 Clinical Phariacologr and Tkerapeatics 25(31:358-371 . 5-flioro- (g ci\| C«-B3-f-12 •» 130.0». HP 282-283 c (iecomp) IISSV8 S068 Hood. Flasu -- S069 Blood. plasu BXVOSOBS IOOTC IP dialyais - Injection Invest ion 1IHTTICII RTBOD BPIC — — — — — ^_— BPLC •OEBSI OF CiSIS 1 11 B1ICB 3. 2110(2-5) -1110(8-71 •olea/1 a] 6.4-29.5 og/nl b) 3.2-17.8 ug/nl c) lot detectable-0. 1 ug/al d) 1.2-11.3 «g/nl e) 2.9-12.2 ng/al f) 0.1-0.9 uq/nl (IIR iili lot applicable a) 13.4 » or - 9.« >q/nl b\| 7. a * or - 6.1 nq/al c» 0 «g/il 11 5.6 * or - ».9 «q/«l «» 7. a 4 or - 3.9 nq/Bl f) 0.3 + or - 0.3 «0/Bl P1GE) S'lIJlL nrCBMTIOI 1? "J,180 •i* «•' start of » hr. " «J»j7Sl« contalnln, nnoles dri,. Initial eeaiuenent. 6X10 (E-6) ?S«"!/Jl ''•titoneal lenls about ta'k »ia»«- Batinated froi Jatient «ith MliqaaBt disease in IntraaMoniaal space. Eo«e-ltBitiB9 tojiclty: Ii;i«?;?rr""l8B' """^Ttopenia. »cositis. laasea, rash, alopecia. CoiBlete or partial mission IB 2 •ith OTarian caacer. MOM! CHHOT1EB4PT: IHTIMB; BtOOD PltS-ll; PniTOHMl FIOIBj IECPLISBS a) 5 Bin after 250 ag. IT t» 10 Bin after 250 ag. IT e) «0 Bin after 250 aql IT ! « "J" after 50° •>• oral e) 20 Bin after 500 aq. oral f) 60 ala after 500 aq. oral. CarciBoaa r«tl«nts, after •attectoaies, Enoland. 01ME9 RKVCR; I9BWSJ ClSCHOtlS; HCOD VLISIl; DBOGS; CO!)P»B»TITt If»ln»TIOIIS: CHBOTBIB1PI Sper«r. J.I. Collins, J.». Deflriek, B.I. Brennaa, B.T. Baeltpitt, i.B. Lander. R. BeTita, T.T.. Jr. "Ters, c.E. 19SO Cancer Research »0t 567-572 Phillips. T.I. Powell. 1. Griere. F.J. Belling. P.S. 1980 Journal of Pkaraaeeotlcal Sciences C9(12\|:U28-ia3i ------- Oracll, 5-flooro- (8 CIJ t»lt) S.a(1B,3H)-Pvrimidiedione. 5-fl«oro- (9 CIJ 51-21-8 Ca-IJ-?-B2 Bt 130.08, IP 282-283 C (decoapl (C01TIIOED) 1ISSBB 5070 peritonea 1 fluid BIPOSOM BOOT! - lllLTTIClL RTHCD BP1C BOB BBS or cisss 10 811GB VOt $iYiM 1B1I 17.6 » or - 7.9 of instilled concentration a br after 21 dialysate containing 5 aB-i BK drag. Bonoexponentlal decline Patients «lth aallgaant disease ia intzaabdoslnal space. rose-Halting toxicity: •yelosappression, tbroabocytopeaia, ancositis. laasea. rash, alopecia. cosplete or partial reslssioa la 2 i 1th ovarian cancer. 91D6S; CHIBOTBBH1PT; S1BTHBB; BLOOD SUSHI-. PEBITOHBAL EUJ1D; BECPIASBS EirEBEBctt Speyer, J.L. Collins. J.B. Dedrlck. t.L. Brennan, 8. P. Eackpitt. I.E. Lender. B. DeYita, ».t.. Jr. Hyers. C.E. 1980 Cancer Besearch •0:57-572 CI, 51-52-5 C7-B10-B2-0-S BI 170.25 tISSBB S071 Blood, seraa 5072 Bilk BZPOSVM SOOTS Ingestion Ingestion numcit SETBOD Badioa«try Sadioaetry or CISES 1 1 ~ 0.0018-0. OC02 radioactive dose/al 0.000 3-O.OOOW radioactive dose/al Bot given (at given C and 2* hr after 100 sg Fropyltkionracil containing 100 nCi labelled drag m: seras aoa-protela boand S activity ratio » 0.55. lactating aether CBDCS; BSOS THIBIM! BLOOB S1BUK: BIIK; LICTlTIOBi SCOTIMD 6 and 2» kr after 100 ag ciopylthioacacil containing 100 ncl latellel drag Bilk: serna non-protein bound s activity ratio - 0.55. tactatiag sother D51JGS; BB06 TIBS1M; BLOOD S1EBS; •IK! HCT1IIOB; SCOtl»IB BZrEREKtt lov. L.C.I. Lang, 3. Alexander. ".0. 1979 Lancet 2(8150) :1011 Ion, I.e. K. Lang, J- llexander, 1.0. 1979 Lancet 2(8150) : 10 11 .£> ro Orea. 1-\|(p-chloropke«yl\|snlfonTl»-3-propyl- (8 CD EenMnes.lfoaaaide. a-ckloro-«-{fpropTla»ino) carbonyl)- \|9 CI) 9«-20-2 CI 276.75, •? 127-129 C (also reported 125-127 C\| IISSO! 5073 Blood, aeraa SIFOSVIS B01TTZ laqestian 1I1LTTIC11 SET BOD OC ROBBER or CASSS 97 34-667 ttBOl/1 . . _ tot giT«o Cese of 125-500 ng 33-90 n old patients «itb •atartty-oaaet diabetes tJOGS; DMBWSS: BLOOD SIBU8; SUDSK BirEBEICS Becgaan, 0. Cbristensen, I. Jansson, B. nihola, B.-B. ostaan, J. 1990 European Journal of Clinical Pharnacology 18: 1«-19 ------- Valeric add. 2-propyl- n CZI 'cla' ' CC-B16-02 If 1M.21, IP 120-121 c ,t t« .. fg. ,2..l3o e at 20 .. B, nssm son Blood. plama ilood. plasea Blood, aeraa lagestloa lagestloa tagestloa 1I1LTTICU. ntBos «e — _ DC ec ntstft or cists 76 6 6 Hisi a) lot givea b) Mot glvea c) lot girea 41 Bot girea •1 tot gir«a f) lot givea 31.8-S2 ag/al a) Bot glTea b) Bot glvea Mil a) 65.1 + or - 20.3 b» 91.7 or - 35.2 e) 5. 6 » or - 26.5 4) 33.8 » or - 28.2 ag/al e) 63.1 » or - 51.9 ag/al f) "3.8 « or - 2«.e ag/al not gi»«a aj 3.* « or - 5.1 b) 27.1 * or - ».« veittii nrotuTioi a) ifter 785 * or - 259 mg/day. atlzares eettrolled h) ifter 785 + or - 259 ag/day. aeizares aot controlled c» after 1002 * or - « 15 ag/day » Fheaobarbltal. Hlztna coatrolled u) izter 1002 * or - 415 a/A«v P.«»ob.rblt.l. ^1,.«. .,? T controlled el tfter 12«8 » or - S18 ag/day » coBtrolld eftBlata. aeizairas 1} ifter 1268 or - SIS ag/day » Ifileptlc chlldrea. Federal Mvablle of Seraaay «-P«DI.IC laereaaad appetite aad might gala. jaatcoiateatiaal diatarbaacea. tiaaaleat hair loss, fatlgae CH1E1T; CB11DRKM; CBBTB1L BnyoOS ITlLVaYIOlS 2."day2 b%SIt218 " 2V2T f°r at 10 hr. Tatlaated froa graph. _ ^ ef aay drag. ** °la C"esl"ul' fc«« trass ; BROS nrnicrioi; IBTJMS; liSSE."8"1 SSBWItSSj ByfBOTICS: imcarynsiBTs: WTWOIISB a) Bay « b) Day 22 il^lll"f a«»4y-atate levela ea 250 ag/12 hr oa daya 1-22 aad 200 ag/day carbaaazaplae days 5-22. Day V ?J levels dlffereat. P<0.0005. * T^ oLfls^ BO othcc dcvos SBOOS: D»5C UtraiCTlOl: iittconvoisins: H.OOB SHBB; »ootts B2FZBBBC1 Klotzff 0. 1980 " lateraatlanal Journal of Clinical Pharaacology. Therapy aad Toxicology I8(l0):«61-ae5 Patel. I.B. le»y, ».H. Co tier, I.E. 1980 Clialcal Pharaaeology aal Therapeatlcs 27(»>:515-521 Bondle, T.I. l»y, I.B. Cutler. e.E. 19T» Clialcal Pharaacology aad Therapeatlcs 2«(5\|s« 29-63 JS ------- ».i«ic .en. 2-propyi-. . Pentanoic acid. 2-propyl-, sodlm Kf 9-66-5 C8-B16-02.a II 17.23 1ISSOB 50TT Blood. plasna BIPOSU1S toori" Inoestlon iBumcu METHOD _ ec •OBBEB or cuts 10 a) 2»2-«11 oaoles/1 b) «62-11»2 unoles/1 c) 335-842 asoles/1 .. ~ BBAI a) 397 + or - 109 nsoles/1 b) 679 * or - 235 aaoles/1 C) SOS * or - 157 nsoles/1 QliUll ISrOBBmOB • • ) Banqe Of llnimaS t) Banoe o( sa«is«es c) Baoqe ol teans ifter si* s««tbs o« daily nalntenance doses calculated (fro. single-dose («00 a,) data) to yi! •""• °J 5" »oleg/l. «•• to peak after sinale dose. 1.8 » et - 1.0 hr. 9-67 T* old «pileptics. vt 27-91 kg. JS08SS D»DO «EB»f: IHTICOBTCISISTS; BIOOD nisn: »osn»ui: COBS»«»TITB IT»LO»TIOBS: DXSUSCS BEFIBBIICB — . Schapel. S.J. Bera. B.C. Doeclte, C.J. O'MillT. '-a- Bcecer »•»• Bisckbletk. B.B.C. SaftSXW, L.». Stanley. .«• 1980 European Journal of Clinical Pharaacologi 17:71-77 - (9 5J-I3-9 C27-B38-B2-C "MSSOE 5078 classa t 23-26 C at 0. ETPOSOBE- B001B • Inlectlon - — 91 SB Bg HETIOO Plnoronetry BOTBZS or USES a) 9 b) 6 BIB6B a) lot given b) »ot giv«n a) 52 or - 7 ng/nl b) 95 + or - 16 ng/nl SB gilEBll IBTOBilHOB . • • a) Besponder. dose 0.066 or- 0.099 t)9/»on-respe.ders. dose 0.189 or- Sesnonders kad ventricular rate of < 100/nin after < 5 eg. Boj-responders kad ventricular rate > 100/iin after dese of «p te 5 nq. 20-70 yr old patients vitl atrial fibrillation or atrial natter. tecraase in ventricular rate. Transient decrease in systolic blood treasure In sone. MD65: B100B PllSSl! HE1BT 01SE1SSS; IIOCD PBBSSOSI; 1501TS BEWBEBCE Doalnie, 3. eclllister, E.G. f«o, c.-S. •eddy. C.P. Snravicz, B. 1979 Clinical Pharnacology and Therapeutics 26 f6): 7 10-71 7«8-9«-5 C1I-B17-I 11 151. ZO, 9f 1ISSOE S079 BlOOi, plasna 1 \ \ \ \ "BMOS9BB BOKt" laqestioa ~~ iB»tyticii RETBOD ec i . BOBBSB or CISBS al « bl » ej 5 1 .1 a) 65-13* ng/»l b) 275- »67 nq/nl c) 597-1373 ng/nl 1 SB»I~ ~~ a\| 103 ng/nl b) 32* ng/nl c) 1282 ng/nl nelians I 1 .« _.. GBBEBll IBrOB»»TIOB a) Dose of 0.39-0.»7 nq/kq/12 hr bl Dose of 1.29-1.6* ng/«/12 nr C) Dose of 2.07-2. «0 ng/1tg/12 »r levels tkronqliont dose interval at tteady state lealtky 19-3€ vr olds, vt 51-79.5 g. fasted before and after dose \| B»1<5S: BICOD Pl»S1l? UBIBS; ClBWk! BirEKBCE »o.i, J.T. Sitar, U.S. cqilvle. B.I. 1979 Clinical Pharaacologv and Tbecapentics 26 (6): 7 29-7 36 ------- 1-ldauatanaalne f§ CD Tricvcl3<3.3.1.1(J,7))decan-f-aaine f» CT) 78-94-* C10-I17-I N 151.2. B 160-10 C. 180-192 C ICOITIIIBD) TISSOB 5080 urine Birosni soni Img«stioa lIUTTXCn SETSWB GC posses OF C»SBS ») 4 b) 4 cj S iiiee «\| 0.68-1. 8W of dose b) 0.85-1.41 of dose C) 0.11-1.4T* of dose Mil a) 1.07 « or - 0.53% of dose b) 1.075 » or - 0.2»< of dose e) 0.««6 » ot - O.SSt Of dOSe CEItBlL IIF08I1TIOI •) Bose of 0.39-0.47 19/119/12 kc b) Dose of 1.29-1.64 iqyltq/12 br c) DOM of 2.07-2.80 q/koyi2 br !i««tio> OB dir '5 BMltbT 19-3« rr olds, t 51-79.5 kg. f»»t«a b«forc and after dos« IHD6S; BLOOD PUSH; OKIE: CilUk; 1 COLTS IERBKIC! aoki, T.I. Si tar, D. S. OqllTie, B.I. 1979 Clinical Pharmacology aad Tberapentics 2«(6):729-73« 1-ttopaftOM, 1-t4-(a-bTdroipb««Tl-l-1-»«tbTl-a-plp«ridTl)- (8 CI1 1-ftopamOB«,1-\|»-(3-brdroxjpb»«Tl>-1-»^bTl-4-plp«riaiBil)- (9 CI) •69-19-4 C1S-B21-1-02 11 247.33, H 156-157 C ussni i 5081 Blood, plasnn I j 1 1 \ 1 1 I 1 1 EXPOS18B BOOTS 1 1 Injection InqestioB aliLTttciL SC/1S 1 1 1 1 1 1 1 I IDHBSB or OSES 5 1 1 1 U16E a) 20.7-49.8 ««/•! b) 8.97-12.69 ng/al BBal a) 35.1 or - 5.92 ng/nl b) 10.79 » or - 1.86 nq/nl 1 5MIEJ.L ItTOBBMIOl a) 0-6 br averaqe levels. 10 mg IT after recovery from anesthesia, 4 patients b) 0-8 hr averaqe levels. 10 mg. crallv. 2 davs post-surgery. 3 patients Coapatel from area-nnder-tbe-cnrve data. Hoee-svrgery patients, ages 20.7-48.0 yi. Heights 55-82 kg. StlBEI; BIOCE PlaSHl; MU.6ZSICS; evoes; xtsconcsi SUECBBT BETEBEBCE Bondessen, 0. arner, 5. anderson. P. Boreas, i.o. BartTlg. P. 1930 European Journal of Pharmacology 17:45-50 1,2-»ropaaediol, 3-lp-cbloropbe»oxy)-. 1-eacbanate (8 CI) 1.2-Pcopanediol. 3-<4-cbloipb«no»y\|-, 1-carbanate (9 CI) 886-74-8 eiO-B12-Cl-»-04 •1 24S.61, HP 89-91 C HSSOS 5082 flood, acrnn ET.MSOR BOOT! 1 1 Inqestlon HtllTIClL RE7HOD GC BOS BE! OF CISSS 4 HUGE 9.29-3.4 ag/nl BBlI Rot applicable GI1IB1L ItrOSH&TIOl fanqe of Kans 1 and 8 br after last ef multiple dose regimen (400 mg/6 hr). Initial value, 5.35 aq/«i at 0 t>r. lor Hi 28-37 yr olds. tHIGS: ItlSBSEBIIT B1TBODS; ILOOD snmii: itnLTS: CBLOSI^E oiciinc ccusoims BITBBSBCI Kaiser, D.6. Sba«, S.R. 1974 Journal of Pharmaceutical Sciences 3C7)5 1094-1097 ------- 1,t-B«phtkalaaedlone, 2- l3,3-dlchloro-2-rropenTl)-3-kTdroxT- 36»17-1«-0 C13-B8-C12-03 n 283.11 IISSOE 5083 Blood. plnsna SOB Drine EIKSBll BOOTE Injection Injection tBU.YT.XCU RZTHOV BadlonetcT Badlonwtry B01BEB or ctsss 3 at « bl < 2.9-0.88 ag/nl a) 23.5-18.7* of dose b) 7.4-1. « of dose Bet applicable a) 33.1 » or - 3.5 of dos* b) 11.7 » or - 5.9* Of dOM Initial neasvrenent and 2« hi after 14 nq/sq n, IT. Cancer patients MUSS; BIOOB Pl»SH»; VBIBI; BIOPLlSBSi CBIBOTBEB1PT at Cnn«latie ercretlon of labelled draq, 0- hr after 10 nq/sq n, IT • b) c»9latie excretion of anckanqed draq 2» kr after 10 nq/sq n, IT Cancer patients DBDC.S; BLOOD PIlSBti OBIBE; BIOP11S8S; CBMOTBIii?! aisais^rara <7,s,-,i.iph..2b,t..»b«t,,5.ipk.,7D.t.,»- fs ^ CT7-S21-B-0» Bl 303.35, RI 59 C TISSBS 5085 Urine ZIPOSOBS BOOTE Injection Serial aBlLTTICtl RETROD — BOB1SB or CUBS — — — — — 11BGB a) 7.8-1.0 aq/hr b) O.S2-0.»5 nq/kr BE1B at Bat qiren bt Bat qiren __._ a\| 2-3 and 5 hr after 200 nq 19 as kTirobroeide t) 12 and 72 hr dnrinq transdernal application, estinated dose 0.5 nq over 3 daws Ittinated fron graph HealthT 16-55 rr olds with kistories of notion sickness Side effects: dry noith, drowsiness. Blurred Tisicn •BOttSs tISIBZ; DBOO THIS1PT: BSOGS KFEBIfCB BcKelvey, E.B. Lonedlco, B. in. I. cbadwick, B. loo, T.I. 1979 Clinical pkarnacoloqr and Therapeutics 25(5 pt 11:586-590 HcKelTey, I.B. toned ico. R. In, I. Chadvtek. B. loo, T.I. 1979 Clinical PharnacoloqT and Therapeatics 25(5 pt 1)jS8«-590 SSYZSEffCS Price, B.B. schnltt, 1.6. ncsalre, J. Shaw, J.E. Trobonqh, 6. 1981 Clinical Pharnacoloqy and Tkerapeetics Ui ------- M 303.35. If 98 C, BP 187-188 C »t 0.1 •• 89 nssvs SOB Bioo4, plena BuosdBE MBfB • _ iBgestioa Xatraaacal »8TBCI> 8C or cms 7 •1MB a) lot giTen b) lot glT«a c) lot glTea <1) lot given e> lot giTen iii* aj 12.9 + or - 2.2 ag/al b) 31.3 » or - 3.0 «g/»l O W.9 * or - «.« ag/sl 1) 170.* + oc - 62.5 ag/ai a) 22.0 « or - «7.3 ag/al SB czimi nroBBHioi a> 1.2 lie «ft«r 0.19 iq/kg. 1»««»»1 «oltitioB. sob tacts k) »7.1 ,1. after 0.38 .q/k,. 1»™«»«J clitio«, 7 subjects c\| 35.0 Big after 0.38 aq/kg. J?™»"«J {CTTStals). 3 sabjects «) 90.7 sla aftec J.O BqAq. lBtr»asal Mlitiai. 5 sBbjects rapme/l's^t.-0 -^ "Utl" ^.SrlSiS.!.?"'" -"•"•• SlgJiBq^-'ft ?r"' "" M'33 Tt' JJ^'J81^'1™10 M08S' »»»wsi ir.mmn>! "°t"! cos""Tln BIKBBHCS •lUiasoa. P. TBB »rk«. C. JatlM, p. Barash, p. BfClt, ». 1980 Cllaieal mnacology acd Therapeutics 27(3):386-39« CI1-B2S-02 B» 312.BB. gp 238-2«2 C (* fora). 239-21 C (- fora) 3 1ISSH8 5087 Blood, plasaa EHOSVBE BOOTE - laqestloa BETBOD . Bit OF CISSS 15 BlBGB a) 1.55-7.55 ag/al b) 0.95-2.90 ag/al c) 1.52-«.Bfl ag/al 4) 0.24-1.20 ag/al e> 0.2»-0.87 ag/al f) 0.12-0.20 ag/al (BBR BUI - a) 3.90 ag/nl fc) 1.90 ag/al c) 3.10 ng/Bl 4> 0.79 ng/Bl e) 0.3 ag/al ft 0.16 ag/al PISB) GBinil IBPOBB1TIOB • ' . dl 43 K ettraiiol ** * 3" ' «thiayl e) 3 br after 30 nq <) 23 br after 30 ng lactatiag feaalea la Snedea !I«BH: IDITITS: BLOOD PL»S1»- ^n.\|f t'CCISTOGHS; COBPtlMITE ' "11V1TIOBS; UCTKTIOH MPESBBCB Bllsson, s. Hygrao. it. Jolansson, B.D.B. 1977 laerican Journal of obstetrics and Gyaecologr 129:178-18* — ,. , _ Ui vj ------- i^o-t1^.^;^^!:'^?.^,^1^ S533-00-2 SS1"^?**2 sr •>••• ff r '+ '"«••>• 'v»-2«1 c '- fo™> irowTTiBHi .. --...,n.r; B • J 1* e ^^» •« TISSUE 5088 Rilll BIWSBBS BOBM Hitmen SSTHCD __ Ilk ioiia or cis is 15 — iiisi . — a) 0.16-1.50 Bg/Bl b) 0.29-2.50 ag/al c) 0.08-0. «5 Bg/Bl d) 0.16-0.63 Bg/al f) ol22-ll 10 Bg/Bl 2} Q.06-0.20 Bg/al ) 0.10-0.30 ag/al it Bone detected }) lone detected BE»» a) 0.51 ag/al b) 1.05 ag/il c) 0.22 ag/ll d) 0.38 ng/al e) 0.3» Bg/Bl f) 0.5 ag/al g) 0.11 ag/Bl b) 0.17 ag/Bl 1) Hot applicable j) lot applicable ~ " GIlIBal IirOBBWIOl ,) freaarsiag. 3 hr after 250 ag » SO ag ethlayl ettradlol 50 ag ethiayl estradlol c) Prenar.lBg. 23 hr after 250 ag * 50 ag ethlByl estradiol i? UostBarsiag, 23 hr after 250 ag » '0 OQ ethlayl estradiol if Wea.relig. 3 hr after 150 «g » 30 an ethiayl estradiol fl po«tB«rsiBg. 3 hr after 150 ag » 30 ag ethlayl estradiol 9) Piea.rslag, 23 hr after 150 ag * 30 aq ethia-yl estradiol i) pistaarsiBg, 23 hr after 150 ag * 30 ag ethiayl estradiol I) P?eBar»iig, 3 hr after 30 ag 1 Postaaraiag. 3 hr after 30 ag 811* erpr«a«ed before aBd after feediaa tiae tactatiag feaale* ia swedea s«BM: atons: BLOOD PUSH: units PBOGJSTOSISS; COSPlSlTllS lilssoa, s. Johansson, E.D.B. 1977 , laerieaa Journal of Obstetric* aad eyaecology 129:178-18« Ul 00 C10-H13-B3 IISSOB 5089 Orlae 5090 1 1 i "BXPOSBSB soo« - lagestioa lagestioa 1 .\ — 1IU.TTIC11 RgTBOD ec-ic sc 1 1 „_ IBSBIl or cisBS 80 i I i •' IlnSS a) 1.6-56." of dose b) 0.»-37.9» of dose c) 3.0-88.3 Of do«e a) Wot applicable b) lot applicable 1 I 1 at 1S.2»« » or - 12. 0« of dose b\| 8.260 » or - 6.9T6^ of dose cl 23.515 » or - 15.026* of dose a) »H of dos« (9.6 b) < 1* of dose (< 0.2 ag) 1 1 — 6111111 MTOMMI01 a) Debrisoqala ti «-OH debrisoqnla c) BebrisoqaiB « »-0!I debrisogaia 0-8 hr eicreticm* after 12.8 ag as salfate. Healthy, 18-«5 rr old Ghanaians. (asted before dose. CHUGS- saai; u«I": RnkBOllsn: tfTlBCtltfS! IDSltS a) is debriscojaiBe H is a-hydrorydebrlswgalne 0-8 hr ca«l»tiTe eicretioa after 20 ag as heiisalfate 70 g, white aale phmotypel as "poor ,€t»bollter" accotdiBg to capacity to «-hydroiylate debrlsogaUe BBd Sfartelne. BMGS: 1STXSCLISB! SFtlSOLIIIS! mini coi!»«wi«* BT»W»TIO»S; "SlTItSSS ITPWOtTCS: WriIPTllMXCS; ilTHT««tisi»i wins: 1 IMIMMttSBlC »6SWTS 1 . BcnsnrcE woolhoase. >.B. ILadoh, B. Hahgoab, 1. Slcxin, T.P. Idle, J.B. Salth, B.I. 1979 Clinical Pharaacology aad Therapeatics 2€<51S58«-591 laaba, T. OftOfl, S.T. Falov, w. 1980 Clinical Pharaacology aBd Therapeatics 27(«):5»7-5»9 1 • ------- C22-B29-»-O2 II 339.«8, II 75-76 C ea. ,- „.„ 5091 Blood 5092 Flood 5093 Blood, plasaa 509 Blood. plasaa Ing«stion ' lagestloa lagestioa lagestloa BETBOD . , GC . oc sc . GC/HS - BHIBZ3 OF CiSIS 16 30 14 . 8 1MSS 0.15-5.8 ag/100 al 0.13-2.** ag/ai a) 150-7 ag/1 b) 78-3 .« ag/al c) 280-95 ng/al d) 180-38 ng/al a) 290->1000 aaoles/1 b) 620-920 naoles/1 flEIT liii 1.03 ag/100 al 0.60 + or - 0.51 a) 63.5 ag/al b) 36.17 ng/al c\| 170.8 ng/al d) 109.17 ng/al - - a) lot giren b) lot giren MGI) GB I III! IITOBBHIOI ~~ fatal cases ia which only ttopoxyphene fonad. Coroners' cases, ages 2-62 yr, froa 3 California counties, cause of death. sticlde, accidental, or aadeterained. lltEl; BtUSS; BLOOD; IlCOBOlSj C»S» •Tsmncs; sncxoE; BBOS IBBSE; Cextroprapoxypheao poisoning latalities. ilcohol and/or other drugs la aost cases. Coroaers eases, ages 16-67 yr. lorthera Ireland Coaa, death Congestion and edeaa of laags. la lose, cerebral edeaa. "JOS; BtOOB: OBIIB; SHICIBBJ »BD« IBHS8; ItmiB; CUB RISTOBIES- fCBIISIC 8BDICIM a) 7 anephrics, 1 aad 2» hr after dose. Initial aeasnreaeat. 135 ng/al J 7 controls. 1 and 2 hr after dose. Initial aeasnreaeat. SO ag/al cj lororopoxyphene in 7 aaepnrics, 3 nad 2a hr after dose. Initial aeasnreMiit. 57 ag/al d) lorpropoxypheae in 7 controls. 2.5 and 2» hr after dose. Initial aeasureaent. 40 ng/al rose, 130 a ------- C22-B29-B-02 II 339. »8. IF 75-76 C (COBTIIOED) TISSUE 5095 Blood, plasaa 5096 Hood, •hole 5097 liver 5098 Urine 5099 nine BXjosoBS BOOT: IngestlOB IngestioB Ingestion Ingestion Injection IngestlOB mimcii BIT BOD GC GC TIC IB ec « Sadioaetry BOB BIB OF CaSSS 10 a a) 16 b) 6* 17 8 B1BGB 85-10 ng/nl a) 93.75-338.75 ng/nl b) 99.38-318.75 ag/nl c) 618.75-1362.5 ag/al d) 647.5-150 ng/nl a) 1.2-35.3 ag/100 g b] 0.2-38. ag/100 g O.OB-6.99 ng/dl 55-75* of total radioactivity lot applicable a) 217.5 Bg/nl b) 217.5 ng/sl c) 1013.75 ng/nl d) 1025.0 ng/nl a) 11.78 ag/100 g b) 9.32 ag/100 g 1.61 * or - 2.0* ag/dl lot givea 1 GSBIBiL IBTOE nation 1 and 12 hr after 65 ag dose as hydrochlorlde 1z/»k. 10 vk Bcalthy 25-3* yr old sea. average »t 8».« kg ElOOD; BLOOD PL1SI1: inlGESICS: OBOG TIZBaPT; COSPmtm 1T110MIDBS a) ProBoxyphene, before heBodinlysis b) Propoxyphene, daring henodia lysis •c\| lorpropoxypheae, before d) lorpropoxypheae, during 130 ng propoxyphene/8 hr, 7 doses. 3-6 hr dialysis following each dose. Idainistered as hydroehloride. Inephric 36-55 yr olds. EBOGS; BLOOD: COBPlBKItB ITitWlTTOWS; IDBITSS HETlBOtlTfiS: IBJIBMCmS; KIBWEI DISUSES; BEBODI1T.TSIS a) ratal cases in which only b) llcohol and proporypheae found Inltipl* drags found in nany canes. In 9 cases of known dosage, fatal dose vas 15-65 ng/kg. Coroners' cases, ages 2-62 yr, froa 3 California counties. Canse of death. suicide, accidental, or ondeterained. IT.VIJ. 9BBGS: BLOOB; 1LCOSOLS; USE •ISTOBIES: SOICIDS: OSOG »BBSZ; CBILDIM; 19ULTS textropropoifphene poisoning fatalities, alcohol and/or other drags in nost cases. Coroners* cases, ages 16-67 yr. lorthern Ireland cena, death. Congestion and edeaa of lungs. In ccne, cerebral edeaa. BB3GS; BLOOD; UBin; SUICIDE; DBUG lEOSS; IBEUIB 0-7 dav cnnnlative excretion after deses of K5, 130 aad 190 aq, oral, aad 65 ng IT of »»C-la1)elled drug \|3 uCl) . Healthy 21-29 yr old. ttUSS; tlalGCSICS: BLOOD pLaSBt; ItQlYS; CO^PIB&TITB BTlLOh?IOVS: n«iB: nn.ina.nui »aoioisoropis ~~" B27EBBBCE Slyvka, G.«.l. Belikian, l.P. Ihyatt, P.l- Beyer, B.C. Journal of Clinical Pharnacology 15(8.9) : 598-60 Giaconini, IC.fl. Gibson, T.P- levy, G. 1980 clinical Pharnacology and Therapeutics 27{») :508-51» Cravey, R.R. Shaw, 9.F. Kakaenra, G.B. 197* Journal of Forensic Sciences 19(1) :72-80 --- Carson, D.J.L. Carson, S.I>. 1977 lancet If 80 17) :8M-897 Gran. L.r. Scaoa, J. lay. «.l. Beltberg, J. Bodin, l.o. 1979 Clinical Pharnacology and Therapeatics 26(»l:B73-«82 ------- 2-aapfctkaleaeacetlc add. 6-eetJroxy-alpha-aetkyl-. {•)- (9 en '*"6 •""' «-~tk««r-«W-~tkTl-. (3)- (9 CIt C1«-B1«-03 H 230. 2C, n 155. J C TISSUE 5100 Blood. plaaaa 5101 Blood. •eraa EifosatE xomz lagestioa lagestioa i Batmen BRIOfi oc BPIC •OBBH or CISBS - 5 FUSE a) lot glvea b) Bot given lot given mi a) 67 ng/mi b\| 62 a«/al »6. 1 or - 5.6 ng/al eiEERlt IRrOSRlVIOB a) Deaa peak at 1 kr, 500 ag doae b) Beav pea* at 2 kr. 500 ag doae Flaa 1200 ag aaplrla tatiMtel froa grapk. aapirla. KG.!?!""* " T Bealthy 23-»fl yr olds, faated everalgkt. Fines : BIDS mmcrioR: im-nru«BiioiT touts; IDOITS; HCtS; BLOOg tLkSBa; CORPllaTITE FVUOKIORS Steadv state level* folio v lag 3T5 ag/12 kr on 4avs 11 to 20 of •atateuaco dose of mtfarla (10 ag dally). RO effect OB boud or free (taadv-state varfarin levels. Wo effect oa protkroabla tlaes. Eealtky 25-C< yr olds, «t 7».1-88.5 tg. muss: iniccismins: IBTI-TmiBRtTOBT 1GERTS; BtOOB SIRO^; IDDITS; COBPUaTITt tvjtnttiois BBnBBBCI Segr«, E.O. ckaplla. B. Forcklelli. B. sevelios. H. aad Tkerapeattc* 15 «) : 37B-379 Jala, 1. Deflation, r.6. Slattery. J.T. 1979* Cliaical Pharaacology aad Tberapeatlcs 25(1):61-«6 2-pipccliiaeaoetlc adl, C13-H17-I-02 Bf 219.31 iissg: 5102 Bloo4, aeraa 5103 Blood, MMSORS BODTB lageatloa Taqeatioa lllLTTICkL RXTBOD BPIC HPIC •OBBSB or CISBS 2 1 a) 590-200 ag/1 b) 0-320 ng/1 0-85 vg/1 a) lot given b) lot given lot applicable Cintll IirOHMTlOi a) 1.0 »ad 3.S kr after aetkylpkealdate. 35 ag 3x/day. iBltlal aeasareaeat. 220 ag/1 tl Initial aeasoreaeat aad 2.2S kr after aetkylrkealdate. 10 ag 3T/day. Tlaal aeaavreaeat, 210 ag/1 at 4 kr latlaated froa grapk Sltalinic acid aetabolite of aetkylpkeallate Bfperactlve 9 aad 1* yr olda CHT10SBI; SU»VIOS BISOEDEBS; BLOOD SIBO»: »RTIMPRJSS1TE IGEBTS; DSOGS: «laSO»E«E»I HITBOBS: RETiBOLISN; BlllBOlITfS Initial valae and 2.0 kr after 15 ag dc»« of aetkylpkanldate. Fljial value 25 ag/1 after 8.5 kr. Vstlaated froa grapk. Bitallalc acid aetabolite of aetkylpkenidate. Byperactlve 12 yr old CBTimER; BEB1TIOB DISORDERS; BLOOD SIBOH: MTIBEPBESSITE AGESTS; DBDGS: H«S»BE9StT HE»BO»S; 1BMBOUSH: BITIBCIITIS BErEBERCB Soldla. S.j. Bill, B.B. BUI. J.G. 1979 Cllalcal Chealstry 25(1)s51-S» _ Soldia. 5.J. Ckaa, 7.—P.H. Bill, B.B. Svaasoa. J.». 19T9 Clinical Ckeaistry 25(3):«01-«0< ------- 2-PiperldiBeacetic «dd. al»ba-pb«Byl-. ""tkyl ester 113-M-1 C14-B19-B-O2 II 233.10. U 7«-7S C TISSU! 510* Blood. serai EIPOSHB BODTB InOeSt iOB 1M1TTIC1I RETBOD BPLC • BOSSES or cisis 1 B1B6E a\| CS-0 09/1 b) 82-21 Bg/1 ,,_ , — — 1B1I a) lot girea b) Rot glren GEBEB1L IBTOSHBTIOB <) 30 Bin and T he after IS J t) BItaliBic «cid (Betabollta) . 2.5 and 8.5 hr after IS ag aethrlphenidate istlBBted trca graph Byparactte 12 re old CBIIDBEB: BEB1TIOK OISOBDBBS: BXOOD SIBOS: aSTIDmESSITE WlltSj DBtJGS; «»SBFBiBBT IBTHODS; RRIBOIIS; •nUOLXflS BEFEBEBCE soldln. S.J. Chan, Y.-P.B. till, B.B. SwaBSOB, J. 8. 19T9 Cllalcal Cheslstrr 25 (3): 401-404 C1«-B21-«-02 259.3«, » 96 C 1ISSOB 5105 Blood, plasaa 5106 Blood, plasaa 5107 Blood. » BXPOSOBS BOOTE Ingestlon lagestloB ngestion n lection IBllRICli IBTBOD rlBoroBCtry oc/as \ 1 \ —\ BOIBEB or cisss 12 a) 17-140 ng/nl b) Bot gi»«B c) »ot gi»en a) 571-2 BBOles/1 b) 79-44 BBOles/1 a) 13-1.4 ng/nl b) 8.0-1.1 ng/nl c) S5-3.7 B9/B1 — (Bt,r a) 48.6 ng/nl b) 77.2 * or - 11.1 c) 41.4 » or - 9.4 a) tot glrea b) Cot 9i»en a) Bot glrea b) lot giTen c) lot glyea t tiif\ a) Before s«rgery " "c.lllster. E.G., Jf. r) it the end of surgery, corrected 1 Bonrne, D.w. for dilation 1 «' T- «• , c) 10 alB after bypass dlacontisned 1 Ericteon. J.L. Dose. 40-320 aq/oay to 12 hr before 1 VBchtal. C.C. surgery, b) different froB a) and 1 T\|' !>p- Waits OB long-tew propraaalol 1 and TherapeBtics therapy for angina pectoris. 1 25(1) n-7 tndargoing aorta to coronary t •rtery-saphenons »ein bypass sargery. 1 CBUGS; o^ne 7BSBi?T; siooo nisii; 1 ITOITS: BBlBt DISUSES: SOBGEBI 1 a) 2 BBd 24 hr neans after 16 ng/days I Johansson, S.B. t) 16 and 24 br Beans after 160 1 •=C»1J» "• US/day la slcn-release fors. 6S 1 WllhelsssoB, C. iioles/1 at 2 hr J \|Jn' 3' ' Bealthy 20-30 Tr olds, rithln 1M of 1 CliBical Pbarjacology ---—-I fjalnlifr 1 •&« TftBjr4ptttiCS Bcrsal .eight. f 27fS).M3.601 Bcdaced resting heart rate and 1 cierclse-lBdnced tachycardia. 1 reduced tlood pressare. I ETOGS; SIECIBi BLOOD PLlSHt; t •STIBieWTIBSlTE 1SSWTS: COSPISWITE 1 nitoiiions: molts: BLOOD PBESSBRB i •) Initial Bcasaresent and T2 hr 1 walle, T. after 0.05 sg/Xq IT. 3 soblects 1 Conradl. I.e. t\| 2 and 1* he after 20 ag, oral. 1 Halle. O.K. Initial aeaeorenent. 1.3 nq/al 1 Tagan. T.C. e) 2 and 16 hr after «0 Bg, oral. 1 Gaffney. T.J. Initial aeasareBeBt* 5.4 ng/Bl 1 979a B«ge of «.« "rtliated fros graphs. I Clinical Pharaacology tata also available for loag-ters 1 and Thera pent Ics aoses «« for napthoiylactlc acid 1 26(5) :548-SS» (Bitabolite) . < \ KcalthT. 22-30 yr olds. »t 6J-S3 lq. t IGWtS; »lOOt PI.BSBM TOIBE 1 1 .» ------- 2-Propanol, 1-(isopropylasinol-3-(1-naphthyloiy) - (8 CI) 2-Propanel, 1-<(1-iethylethTl\|asino)-3-(1-na)>hthalenyloxr)- (9 CI) 525—66-6 C 16-B21-I-02 II 259.34, BP 96 C (COHTIHDED) HSSOB 5108 Blood. plasoa 5109 Blood, plasma 5110 Blood, Flasaa 5111 Blood, plssoa . El POSH BE ROUTE Inqestion Inqestion Inqestion aULYTICAL HETHOD Fluorometry GC HP1C Pluoronetry mjHBBH OF C«SBS s 25 7 sues - a) 45-222 ng/al b) 37- 28J no/«l 5-121 ng/Bl a) 2-7 ng/Bl b) 13-51 aq/ll C) 57-279 ng/Bl 4) 19-174 ng/nl e) 534-170 ng/nl f) 1667-509 ng/Bl 9) 15-8 ng/Bl h) 4372-4288 ng/ml _. _ . . . _ a) lot given b) Dot given e) Dot given - IBM a) 169 » or - 72 nq/Bl b) 169 « or - 79 nqyul lot given a) Hot give b) Hot give c) Sot give d) Hot give el Hot give f) Hot give q1 Hot applicable h) Rot applicable ng/Bl b) 93. S or - 44.8 nq/ll o) 115. 1 » or - 56 nq/ml SSHSBit IHFOSBaTIOH a) Propcanolcl h) Propranolcl 4. qnlnldlne Ivecaaa steady state 0-6 he after 80-«q dose. Qainldine dose, 200 mq. aealthy 22-H6 yr olds. CHUGS; DRUG IRTERaCTIOH; BLOOD PH31J: JHTIIHBHTTHHIC JGESTS: >DH1TS tcse, 1$0 oq/day. Thrcotoilc 17-65 yr olds. nausea, lethargy, insoania. ligbtheadedness, and diarrbea. Cecreased neart rate, vt change sl9nlf Icantly related to plasma levels. D1ITED KIHCDCI: BLOOD PUS HI; DBBG TEEB1PT; DBDG5 a) 0.5 and 2 he after 20 nq. 3 ng/sl at 8 hr b) O.S and 2 br after 80 ng. 18 nq/al at 8 hr c) 0.5 and 2 hr after 320 mq. 118 nq/il at 8 hr d) Raphtboxy lactic add (HIA) , letabollte, 0.5 and 2 hr after 20 ing. 40 nq/nl at 8 hr «) HL> 2 and 8 he after 80 19. 242 &9/B1 at 0.5 hr f) Hit 2 and 8 br after 320 nq. 705 ng/nl at 0.5 hr g) Before and after heBodialysls, unspecified doses h) H.I before and after heiodialvsis Given as hydrochlorlde a)-f\| locial dales. Other •etabolltes also aeasured. 6 nornal 23-32 yr old Bales, fasted before and after dose. 14 21-65 yr o!4s on long-term hemodlalysis. IHTIHTPSBTIRSIVB aSBHTS; DRUGS; BIT1BOI.ITBS: BLOOD PtSSIS; PPOTMHS; tPISB: KTIRET DISEtSES: HEBODIiLTSIS; ItOlTS hydralazlne e) Peak, propranolol * SO aq kydralazice Cata also for absorption studies. Horootensive 19-31 yr olds, vt 4«-90 kg, fasted before dose. Decreased pulse rate, blood pressure. Faintness with hyiralazine plus drag. imttYPBRTtHSIVB IGBBTS; BLOCD pitsii: 1BDITS: Ditne IBTEB»CTIOS: ELOOD P!tESSnKE: EHZTKES: ltiSTBM.Il BEFEBEHCE Fenster, P. Perrier, D. Hayersobn, H. Rarcns, F.I. 1980 Clinical Pharmacology and Therapeutics 27(») :4SO-4S3 Feely, J. Stevenson. I.R. Crooks, J. 1980 Clinical Pharmacology and Therapeutics 28(1): 40-44 Schneck, D.H. ?ritchard, J.r. Gibson, T.p. Vary. J.B. Bayes, S.B.. Jr. 1980 Clinical Pharmacology and Therapeutics 27 (6): 744-755 ffdean , &.J. Skevs, R. Eobik, 1. Dudley, P.J. 1980 Clinical Pharmacology and Therapeutics 27(6):726-732 (H3IT OJ ------- 2-Ptopaaol. 1-oJ-3-t1-Baphthal«Byloir»- 19 CI) 525-66-6 CK-B21-I-02 II 25.3». IP 96 C TISSUE 5112 Blood. plasaa 5113 Slood, plasaa Blood. 5115 Blood, nposniB BOOTB Injection lagestioa Ingest Ion iBlOCtlOB Tagestloa • MlYTICAl BCTBOD Flaoroaetry ec Flaoroaetry ladioMtry Sadlosetry Flaorosetry BDRBBB OF CASES 10 24 IS 5 •) 25.4-24.3 Bg/al b) 31.3-31.7 Bg/sl a) 5.5-152.5 ag/al b) 56-290.0 sg/sl c) 97.5-580.0 ng/al d] 67.5-1,330.0 ag/al 3.2-15.6 ag/al a) 30-63 Bg/»l b) 39-142 eg/si a) Vot glvea b) lot girea a) 69.4 ng/al b) 158. 1 eg/al c) 339.0 ng/al d) 607.6 ag/al 5.40 ng/al i) 41.5 ag/al b) 79.2 ag/al a) d-Propraaolol after iafMloa of d-fora b) dl-Propranolol after infusion of dl-fora 1-4 br range during 4-hr Infusion of 0.04 ag/kg/hc Data shov that propraaolol depresses. •ithovt altering the glucose carve. glacose-stitalated insulin levels. lealthy. noa-obe»e 25-37 vr elds, oa SCO g carbohydrate diets >3 days. dl-fora redaeed blood pressure rsoes! BLOOD PLUIA: CMIOI: BITISOII5B: ELOOO SEBDB: BOtBOHBS; HOOD P»«SSOBB; ABBTTS a) 40 eg 2i/day b) «0 ag 2x/daT c) 169 ag 2i/dar d) 20 ag 2 I/day t.-2.S hr after aornlag dose 2«-62 yr olds, «ith essential hypertension. lever blood trestares and pulse rates. Fatigue, di«laess. chaage in tovel habits, algbtsares. IS9SS1 91106 TBBPaPT: ABTIBTPBBTESSIVE leiirs: SIOCB PBISSOBS: BTFIPTEISXOI; It BITS: MItIB HBGBOS; CO»P»BIH»E tmOkTTOWS; MUSES — — Steady state levels after 7tb dose of «0 ag/8 br. aad 40 ad of 3B-propraBOlel IT Icraal 23-55 yr olds, vt 56-92 kfl. esucs: BsriBoiisi: IDCLTS; BIXXJE: BtOOD P11S!11; AICOROLS; SSISBSSBWT a) stealy state, 80 ag/8 hr r\| Stealy state, 80 ag/8 hr plas eblorprosailBe. 50 aq/8 hr Idalts, 4 aoraal aad 1 hypertensive, ages 21-33 yr. giOGSt 9B3G laTEHCTTOI; TZnSS!3; ctocQ pits'i: aooiTS: BT?tsrt«slol; ilFEBEfCB Brers, B.C. Bope-eill, B.P. 1979 clinical Pbaraacology and Therapeaties 25t3):303-308 Serlin. B.J. OrM, B.l'B. Baber. l.S. SibeoB, fi.G. Lavs, t. BreclceBridge, A. 1990 Clinical Phanacology and Therapeaties 27 {•!): 586-592 xonha«s«r, 9. B. vood, l.J.J. yestal. B.E. Wilkinson, c.e. Branch. B.A. Sband, D.6. 1978 Clinical Pharmacology and Therapeaties 23 (2): 165-174 vestal, B.E. Korabaaser. 3.8. Bollifield, 3.9. Shand, B.C. 1979 Clinical Pharaacology and Therapeaties 25 (1»: 19- 24 (•Bit PIGI) ------- Bl 2S».3«. IBSM S11C Blood. »!••• 5117 Moo4, 5118 BlooA. 5114 Mood. «r»« 5120 Blool, whol« "BIPOSIB BORI Hontloi luiTTIOU HBTBOD ec/is BUG n»oroi«try B»LC or cuts - 5 3 35 _ •1 S »l 2 ct 1 4) 1 IS (con file? b) 75-29 »o/»l c\| 73-2SO mq/ml •- . C-31C n»/.l •) >0-57 ng/ol b) 50—80 kf/ol c) lot «pplie«bl« <) ot cppliabla 33-1W sg/tl II KIT 'Itno) ~ JB1B f __l. •1 63.6 ig/.l j b) U2.2 •«/•! ! Cl 12.2 4/.1 { 1 I Wot 9iVM 1 i i \| Bot giT» ! ' ! 1 j J 1 1 1 _!. «l Bot given i b) Bot givoft \| c) 120 Bq/il i d) 212 no/il i J J • J 1. 72 nj/,1 J 1 1 I 1 Bleu! " • — 1— «inu MFBBBICE assrsatr— ••— itpzmisioi: M; CO«»lBTtl nts»: OBIM SSL I i^SrCk CO"»«iC«tiOB ' " i^Iif?1 ?«t««oio,, co.plTi., Ln ------- -Baphtbyloxy)- (8 JSS-6S-6 C16-B21-I-02 II 259.3, BP 96 C (COIIIIBBD) iissns 5121 Urine 5122 urine 5123 urine EtfOSUSI KOOTB Ingestion Ingestion Ingest log IMLTTICIL BBTBOD GC/BS HM.C ec/ss or cisis 5 2« B1IKB lot given a) lot girea b) lot given c) lot giT«n d) lot girea a) lot given C) lot giTCB a) lot gives b) lot giv«B c) lot given d) lot given BE1I Ik* it dose a) 8. 3 * or - 1.6* of dose b) 13.5 * or - 2.S* of dose c) 15.0 * or - 6.5* of dose d) 39.2 » or - 2.8* of dose £) aa.6 * or - 5.2* of dose a) 3. 1* of dose b) 9.2* of dose c\| 16.0* of dose d) 18.0* of dose tally excretion OB chronic therapy of eo to 960 ng/day (every 6 kr) . Hypertensive patients. DB0GS: SSTIBOJ.ITBS: IBTIHYSBBTEISIfB IEEITS; BLOOD PtlSBI; OBIIB a) Propraoolcl, 67 naole dose B) Propranolol, 268 ««ole dose e) Propranolcl, 1072 nnole dose d) Propranolcl » setaboUtes. 67 anole dose e) Propranolol * aetabolites, 268 f" Propranolcl » setabolites, 1072 stole dose Given as hydroehloride •8 hr excretions lorsal 23-32 yr olds, fasted before and after dose. MTIBYPESTBISiyE IGBSTSi DBOGSs JITtBOlITIS; BtOOB P11SB1; PBOTEIISj OBIIB; KIOlEy DISEtSIS: BEBOBI1LTSIS; lEOlTS — — " "~ a) «0 ng/day b) 160 sg/day ci 29 eg/day d) 320 ng/day. excreted daily as the glnearonide after long-tern tterapy ith dose indicated. Bypertension or coronary artery disease patients. CBGGS: B8UG TBTTglPT: BTPEBTBBSIOWi C»SBIOT»SCTO»B OISEAS^SJ COBPIBITITE M»IIHTIOS: BIOOD pisssi: OBIIB — — • ~ TirEBEHCE — walls, T. conradi, B.C. •alle, O.K. Fagaa, T.c. Gaffney, T.S. 1979 a Clinical Pharaacologv and Tkerapeoties 26 (5) : 5«8-«» Schneck, D.«- Pritchard, J.P. Gibson, T.J. Tary, J.B- Bayes, 1.8., Jr. 1980 Clinical Pharsacology and Therapeotics 27{6):7»«-755 Halle, T. Conradi, B.C. valle. U.K. ragaa, T.C. Gaffney, T.E. 1979b clinical Pharnacology and Therapeutics 26(6): 686-695 ------- 1355-52-2 C 1S-B23-W-02 II 2«9.39 i-co-BllylpheBoxT)-3-{iopropTlaBiBO\|- (8 d) 1-}<1-BeihTlethrlU«i«o)-3-(2-{2-propeBrl\|phe»«r}- C»CI) tissai 512» Blood, plana 5125 Blood, plasaa IZIOSnC SOBTB Inqestioa Infection laqestion iiiinicu nraoD ec GC-SC •DHBIS r cisss 1 1 « iiiii ' a) 29-90 BBOlAS/1 b) 8-9 » aaoles/1 C) «-122 BBOles/1 4) 22-9* BMles/l a) 100-15 FBoles/g b) 37-12 psoles/g c) 115-3* caoles/q 4) 125-12 naoles/g e) 200-6. 5 pnoles/g 5Ii i "" GEitMi nrosHttioi i SEfEBEics i j a) «0 BBOles/1 ! •) alprenolcl. 90 .la after 0.2 q 1 «"f«; p' b) 38 ».ol«8Xl 1 b) Ilpra«olol, 90 .i» «ft«r 0.2 g. 36 !«"«»• p- c) 80 naoles/1 1 »t after last ot 10 doses J Borg. K-o. ?> ss »«ola/l 1 i«atobacbltal (0.1 g/Say) » "aglanfl. K. 4) 55 .iol.s/1 1 «"™j;4ro)tj..ipl.1. 90 ai. after 1 »« Bahr. C. l fl 2 a ^ i9'9 «i 1 a?kTae8«I-al\|,r.»olol. 90 ai; after 1 "Vi"!^?"01" i 0.2 q. 3« ar alter last of 10 loses 1 «a.;k!"«£ie8 \| peatobarbltal (0,1 g/«aT) 1 25(«) :«23-«27 \| t«tobarbital effect OB Beaas 1 \| siqviflcant. P<0.01. 1 i « I ICBsaolciaq 23-31 TT olds, nith BO 1 1 «Tl4euce of iis«ase or flrog Intake. 1 \| iBhibltloB of exercise tacblcardU 1 I taring » 7 he period vas reduced froa I I «.0 to 10.7* br peatobarbltal 1 \| (redectloB correlated »lth plasma 1 1 levels). ' tines; HBTIBCLISB: BWTSIS; I BTTn^nsToi: BLOOD PLISHI: C« In eierclse heart rate 1 correlated «ith log plasaa lerel. 1 CSIGS: stfMii: JLDHWS: HIPEBIBSSIOH; i HTlBOtltlS: BLOOB PLtSHl; IBOTIUS 1 2S839-7S-8 C13-H«-i»-03-S II 31«.»Z. HJ 71.5-72.5 C 1ISSHI 512« ElOOd, plasna sxrosnfts some - lagestloB alliniOL HCTBOO OC-BC IOHBSK OT CaSSS BMGB 173-3 BBOlesA i»1 Rot giTen GIlIBlL Iir08»»TtOS 1 2 «aS ao he «eins after 20 eg/day Sealtby 20-30 Tr olds, within 10« of noisal weight. Seduced resting aad exercise heart tates. Seduced tlood pressure. Etaes: snosi: BIOOD PUSIII: laTIHTPIITWSITI 4GEMTS; COnflKWTYE gt»LUlTIOS) 1DQ11S: BtOOD IBESSttSI Johansson, S.F. HcCall, II . wil&elasson , C. Tedln. J.I. 1930 clinical Pharaacology and Therapeutics 27(5) : 593-601 (IE1T PISE) ------- ^^ J6839-75-8 C 13-B2»-««-03-S 81 316.»2. BS 71.5-72.5 C 1ISSOC 5127 Blood, sera 5128 Urine EtPosnBS SOOTI Inaestion IngestioB ilaLTTICIL BETBOD GC-SC GC/HS Radionetry _____ _— — — BOBBBI OF C1SES IS 3 IMSB a) 0-86 ng/ll b) 30-156 ng/n.1 c) 39-171 ng/«l lot giTen Bill a) 42 ng/al b) 77 ng/l c) 96 ng/nl 77 or - »% of dose J__._ ' " — a) 20 g/aay t) ao sg/day e) CO nq/day Ifter 3rd week. 2-« hr after M dose. 23-56 yr olds, slid to soderate etsential hypertension , » no-25 yr. C black. 11 unite. flood pressure, heart rate, and plasia renin actirtty decreased. EBDGS; oans THSR»PT: HTPMTIISIOK: IIOCD SE^OB; conPatwiys iy»toatio»s lose. 10 nq C1«-ttnolol 2 hr excretions Bealthy yolnntears I)BIR«: 1TT1BCLISS; SMS; DSOCS SEFESEHCE Slnoa, 6. Kiowski, >. Julias, s. 1978 Clinical Pharnacologl and Therapeutics 23 (2) : 152-157 Tocco, D.J. Duncan, i.E.V. delnna, F.I. snith, J.L. Falker, S.». TandenheaTel. S.J.. 1980 Drag Hetaboliss and DispositiOB 8(«) : 2 36-240 2-eropaBOl, 1-(2-CTClop«tilpliei»»r»-3-( d. 3«507-aa-9 C18-B29-»-02 R« 291. 00 ussm 5129 Bloo4, plaaia 5130 Urine IIPOSDIE BOOTS InoestloB Inoestlon »»»tmc»i CETHOC HaoroKtrT Flvoroietrr ID8BES OF C1SSS 12 12 MICE a) 403-356 ng/il b) 37«-2191 »g/«l c) 283-661 ng/»l a) Rot given bj lot gl«en e) lot gi»en > ' \ a, ,239., . or - 225 j »J.;«e'«.Ti.^S,tta" \ ~">, 7 * °' - '" oS^r'.^.r,^^,— ^ ! SSK.^. SS" * or - 31-7 i ?-^s- ^."i^.1"1 ""* i SFt! J:T- 1 HsalthT 21-«S yr olds. »t 160-180 I Joarual of =li=ic«l ! lb""o iruqs > 10 4ars. fasted 1 Phar.acolo, y 19:«15-a23 I before and after dose. 1 j HeJnctlon in restinq and eserciae 1 i heart rates and systolic pressure. 1 1 giastolic effects less consistent. 1 1 EFUSS! »ITIHIPWT!»SITI »SI»TS: BLOOD I \| H'SSflBS: BLCO9 PllSBi: OBUI; IDOITS 1 1 _ ] Swis ilH-lL .,„»... liife,. . • t HOTOSt • E« •ealrty 21-»5 yr olds. «t 160-130 t ftevart, J.T. 1 Its. «o r«gs > 10 ««ys. fasted 1 1979 before a.« a«.r do«. . :~^,^;^t«l I telnctioa IE restlaq and eiercise 1 I heart rates and systolic pressure. 1 I Clastollc effects less consistent. 1 i ' 1 C0es-. MTlSWCTtWISTT! \G!«TS: BIOOD 1 1 H'SSHT1!: ?1COB M.»S^\: T!SIt; WOltS I I 1 — — ' ' ------- CH-B25-B-03 It 267.3 TISSOX i nrosBBB Boni" 5131 Blood. Plasaa 5132 Blood. plasaa 5133 Plasaa 513* Plassa iBoestioB Ingestloa iBOestioa Tagestioa lUlTTICal HBTBOO SC 8C SC-BC 9C-SC or CISBS 5 a) 12 b) 8 lues •I 1237-20 Beoles/1 b) 605-56 BBOl.s/1 a) 27.1-76.1 paole/g b) 53.5-17.7 paole/g c) 162.6-aio.S piole/g 4) 130.6-199.B peole/g , ... a) Bet given b) 111-325 eg/el a) 68.1-«67.1 ag/sl b) 120.S-1C66.7 ng/sl OESI a\| Bot gives b) Bot gives a) 60.0 psole/g b) 106.1 paole/g c) 265.8 psole/g 4) 166.5 paole/g a) 323 « or - 98 b) Bot given a) 198.9 « or - 37.7 b) «26.1 + or - M.I (S.S.J (MIT Pas) SBBHB.1 I,™.,™, a) 2 aad 2a lr seaas after 200 tg/day b) 2 aad 2* hr seaas after 200 sg/day a» slov-relcase fors Bealthy 20-30 yr olds, withia 10« of •orsal velght. tadaced resting aad exercise heart rates. Seduced blood pressure. MOSS; StIDZI; BIOOO PLlSfll; • RlBtEBTI(SiyZ iGtltS; COBPlBaTIVB iTaLnno«s; iDviTs; HOOD PKSSTOZ a) 25 ag/day, 2-5 days b) SO eg/day, 3-7 days c) 100 ag/day, a-9 days d) 50 ag 3z/day. 25-72 days iverage levels for 1st 7.5 br after dose, (area-aBder-tae-coxve/tlae) . 30-«6 yr olds, witk hyperteasloB 0.5-3 vr. iBtlByperteasive at all doses, p < 0.05, lomred palsa rate, all doses. c < 0.01. B.Hi pi. doses lomred Flasaa renin activity IB a of 5 eases. tlOGS; OIOG TBKSiPI; BIOOO nESSQBB- lIlIHTPBBTtBSITZ KBITS; SVBDEB; atTltS; COaplBlTITE ?T»LU»TIOIS; XTCOD msvi — — a) after 1 «k oa 200 ag/day. tiastollc iressere responsive to low dose (qroap t) b) 1 and * vk. Dose 200 sg/day 1st «k, 300- BOO eg/day th vk. Olastollc rtessere respoasive oaly at higher doses (qroBC B> Ul s«1ects given 50 ag 2I/day hydrocBlorotUazide > 9 vk before ictoprolol. 21-« yr olds. »t 55-105 kg, vith tlld to soderate hypertension. It diced blocd pressare, redacel heart late aad plassa reain activity. tlzzlaess aad fatlgae. rsness BTPS»TBBSIO»; 91000 pizssnas- BWSBTICS: IBTlBIPEBTEllsiyi 1C! UTS; BIOOB PHS1I; 1DDITS a) Jfter single, 100-ag lose. Peak at 1.7 » or - 0.2 hr 10C-600 ag/day. Peak at 1.6 * or - 0.2 hr adsialstered ai tartrate. Rynerteisive 30-69 yr olds, fasted before first dose. Elaed pressure and heart rate decreased . EBOSS: DIDO TBMIPTS »BTiBtsz»TWsiyi 16SBTS; HYPmiBSIOII: BtOOD PllSKt; EICCD PMSSIJUE; CIMIDI; 1DVLTS BBTESERCB - Johansson, S.E. Recall, a. Vilhelsssoa. C. Vedia, J.i. mo Clialcal PharsacologT and Therapeutics 27 (5): 593-601 Collste, F. Baglaad, (. VOB Bahr. c. 1980 Clinical Pharaacology aad Tierapeatics 27(«):aai-a«9 yelasgnei, a.T. Van, S.R. Haroade, B.r. 1979 Clialcal tharaacology and Therapeutics 2«(5):'!5?-561 Ryers, U.S. Thiessen, J.J. 1980 Clinical Pharaacology and Therapegtics 27(6)8756-762 vO ------- 2-Propa.ol. , 37310-58-t C1«-H25-«-03 •I 267.J« (COiTHBED) 1ISSOB 5135 Blool, Flasia - 5136 Blood. plasaa 5137 urine 1IPOSDJK HOOTB In oast ion Inoestion - Inoestion IMLTtlCtl HRBOB ec OC ec Saaioaetrr IDIBSB or cisss C B 10 HteB a) «ot applicable b) lot applicable e) lot applicable a) 360-1200 naoles/1 b) 230-1100 moles/1 a) lot applicable b) lot applicable c) let applicable 4) lot applicable — a) 135 »J/»1 b) 77 ng/al c) B9 »g/«l a) tot glten b) tot giten a) 2.7« of dose b) 3.5* of dose c) 97.5V of dose 4) 99.6? of dose a) Bean pea. 87 »u' . 20 "i tablet (59« released by 2 »« e* lean pea. 28i .i», slo. release tablet (3»« teleased b» 2 hr> - 180 ml. single «««• •• tartrate. Be.lthT 23-2J »«•" bt b«for« ana » fcr aft«t caused MXia» 17- rat Iffwt. lrls. r>9.9«. K0.001. DB»«$! 9100B tlURll 3SHJ CC9VM1TITI IT110HIOSS: SKBEir; BlOOt PSZSSBRB a) ?eak». 1-3 »' «"« «-' * JS hr t P«ak«. 1-2 r alter 0.1 9. 36 hr aft«r 10 «aT« i««tobarbUal 10.1 Ke.-U«l«-t»e-c,rT. r.4«rt by after paatobartital treat««nt. BealthT Swedish «t«d«it8. ages 2-37 ", no«aoer«. tast.a OTetalqht to 2 it after «OS€. tunes- DSOS nrwictioi: "MD MisS»: BIOOD misson: S«B»M: IC1LTS «toprolol. slo«-r.lease ^e aetoprolol. riatoactiTitT. slo.-r.lease * raaioactiTitT. 72 fcr etcretloas after 50 •« ttitl««-labelle4 d«» as tartrate 10 lieaXtiT 25-6 Tr oias. fastea 10-12 hr 1-«t<:r« » • fcr aftet aose caaael «aiiia» 17-19t rate. »•« »!»» »» J«ects eorr.late4.ith ItTels. r>0.96. P<0.001 E»ieS! BIOOB Pl»S8»: cei«»i»TiT! miowt SISDIW, BtOOB PHZSSOW »»loes- m.,, »BOHS: c-s. icta pharsacoloqlea et toiieol09lca36(Suppl I. seiaeian. P. Collste. S. Borq, r.-O. von Bahr. C. «79 Clinical Phar«acol09T as3 th«tapeatlcs 26 (3) s 326-329 teqaraii. C-B. johasson, 6. Jordo, 1. SoUsll. 1. »cta ?iar«acologica et Tozlcoloqica 3* ------- 2-tropes-1 C1«-B1T-Br-B2 •1 317.25 3- C-broaopV..,!, -..„,,..«,,„_ ,3.pyttai.rl, _, (J), •ot glre. lft.r 50 a, HeeUdiB.. 31/dar. 3-6 "Uh °* .. --- r---^f aaasea. bioclMBlcal «Mects la lii«r 5 r«cor«Td froa depression. ' Baasea. l.B. Tboasea, I.s. Testergard. P. larsea. 5139 Blood. ec IOBBSH or cisss 10 C21-B29-B3-0 «I 339.»7, HC :: ^SfflSs-cTO.^.^-.^^ ni«B ' • 50-300 aaol/1 "mi ~— •ot gi«B (9 CI) 26.6 c»«t nair !"« •"> »«. M/«aT. 3-6 .k S«a4i-atat«s Istlaatsi (to. qrpi» * itt B«aiark ™:, 88 o ?: u ?stlpttl<>B' »a»««a. tloch«.ic.l «tf«ct» i» lll r«co».r.i fret d.pr.sslo" BISOBBEBS- Baasaa, l.B. Thoisen. I.s. Testergard, p. larsen. C«atli fro. « TT «U f«nle Car4iopillan(tT arrest «oes; siooD; oBns IBBSE- ' , .. Stafford, tt.T. tell. j.s. 19SO Joarnal of Forensic Sciences 25(11:33.39 ------- 2-PyrldlMacetaaite. 2-Pyriilaeacetanide, 1737-09-5 C21-H29-B3-0 BB 339.»7. IF 9.5-95.0 C - c. ex, IXSSBB 511 Blood. Blood. elassa 513 Blood. seraa BIMSDB3 BOBIZ -- Xagestion lagestioa • lalection AULTTXCiL BETBOB BM.C me ec - BOBBEB OF C1SBS a) 5 bt 6 6 9 a) .5-S.» sg/al b) 5.0-7.1 ag/nl 3-0.2 v«/nl at 2.6-1.85 ng/al b) 1.71-1. »0 «g/al c\| 0.66-9.«0 og/al dl 1.9-0.1 «g/sl 1 BEIB a) .9 • or - 0.6 b) 5.9 * or - 0.2 «g/sl Bot given a) Bat applicable B) lot applicable e) Bot applicable 1) Bot applicable . _ t) 200 ng « i/Jay aainteaance dose Byocardlal iafarctloa patients, ages ««-73 yr. «t 62-90 kg. Bpocs; inmiiii: RSIBT DXSEISBS: BICOD nisii: sine TBSBIPT; iftttiis 2 and 58 ir after 200 sg dose as Tbospaate. Initial aeasareneat. 1.8 ag/nl at 0,5 ar Baage of seals, estiaated froa grapb Fatients vltb renal Insaffleleacy regnirlng loig-tera aenodlalysis ItlllTS: BBMT PKB»SIS; IIBBR EISM5M: HniBBBTtmic IGIITS: OBVG ICEBIPT a) 150 sg dcse. followed by 8 «r If b\| 75 sg dose, folloned by 8 or If of cj 25?sg dose, followed by 8 »r If of 2.5 aq/hr d) 2 and 30 fcr after 2 ag/kg bolus IT, 8 sab-teets. Bstisated fron graph at -e) 0.5 and B br after start of dcse, 1 snblect. Borsal volunteers BBitw KiBeec"; IDBHSJ BLOOS SIBBB: iBTiisaananc iciBts; DXTOS ttnazfcs Ilett. I.F. Badsen, B.B. foods. J.D. 1979 Clinical Pbanaeology and Tberapeatics . Sevka, B.J. Ratthews. S.J. Blghtiagale. C.H. Izard. B.f. Fiellsan. 1. cho«, a.s.s. 1981 Clinical Fbarnacology aad Therapeutics 29(3):322-326 Lawrence. J.H. Brysoa, S.B. Snsner. D.J. 1979 Biopharnaceatics and Drag Disposition 1:51-57 •-J N) 137-5B-6 68-69 C. BP 180-181 C at » an Bg, 159-160 C at 2 an Bg TISSVK S14» Blood, plasaa BXPaSBBS BOOTB Injection Inaestion (octal 1I1ITTIC1I arraoo oc HlflBtS OF C1SSS B1ISB a) 0.3»0-0.59« ng/1 b) 0.085-0. «60 sg/1 c) 0.23-0.829 ng/1 (Ittt RIB a) 0.«9« + or - 9.09 ng/1 b) 0.26* * or - 0.11& c\| 0.529 + or - 0.22J nq/1 ntsi) at «0 aln Tf 11 oral lone (capsale) c) Kectal dene (agaeoas solatioal 0-8 kr average levels conpated fton aiea-«nler-tbe-cnrre/«90 nla. 5os«, 200 aq If, 300 ag oral or rectal. lealtar 23 to 26 »r olds. «t 65-85 kg, fasted before dose. vsoesj ^BT»»Bla»DS: 81003 fi»S"»; CC>m»iTTf» lfHO»TIO!IS; iBWlTS; ftOCO BEFB9BHCE de Boer. .G- freiner. D.9. Battle. H. Prosit, 3- Gabbens-Stibbe, J.R. 1979 Cliaical Pharaacology aad Therapaatics 2«t):701-709 ------- fI;f.'"fr°JT^U' -Mi«t»rl««l.o)- (8 CD m-sJT* 2-'dl«t^1"1"»-«-».«-«l"t»riS«rii- (9 CD CU-B22-B2-0 •• 23«.33. BP 68-69 C. BP 180-181 c .t • .. B,. 159-160 C at 2 .. Bg T1SSBB 515 Blood, Flana - Blood, •hole B&PQSOU 1OOH iBjeetloB iBJeCtlOB Ingest ion lectal IBURICil BZTBOB as ec ttriBft or cms 6 " iiifii ~~ 1.8-3.2 ag/al •) 0.30-0.57 Bg/1 b) 0.079-0.35 Bg/1 c) 0.206-0.60 ag/1 ! BBll 2.5 ag/sl a) 0.398 » or - 0.098 Bg/1 b) O.m » or - 0.102 Bg/1 c) 0.377 » or - 0.12 ag/1 GJItUl IBFOIBITIOB — • _ §2 'I0?1** ••»• followed hT°12 kr IT °" 30 Qg/kg/sin. Levels of 2 aetabolites also aeamred. leaal failure patients OB caroaic heaoaialrsis. either anephric or «ith creatiaiae clearances of < 5 al/»in. Bo congastive heart failure or liver »c central nervoBS avsten toxic itr or changes in heart rate or Mood pressure. BOTGS: BBTIBOHSB; B10OB PIISB1; DISBftSBS a) 60 Bin IT r) Oral dose (capsule) c) Beet a 1 dose (aqneovs solution) 9-9 hr average levels coaputed froa area-nnaer-tbe-c«rve/«SO ain. Dose. 200 Bg If. 300 a ------- 28-1,2,»-BenzothladialIiie-7-salfOBaaid«. «-chloro-3,»-dihTdro-2-nethrl-3-(((2,2.2-trlf laoroathrl) thio) Methyl)-, 1.1-diozide 3»6-18-» C11-B13-Cl-F3-l3-0«-S3 tl «3.0, He 202.5 C, also reported as 207-217 C tISSOS $18 Blood. plasia 519 Urine EXMSOBB BOOM Ingestion iBgestioB aUiniClL (1ST BOD OC GC IDHBE8 OF C1SBS 18 13 MWI 0.61-1.0 ng/ml 11.62-32.5m of dos* mi lot applicable 20.31 of dose GEIEMI IBFOBHTIOI Bange of seans, 1-48 hr after 1 »q. Peaks at 5 hr in nost patients. 83.5V protein-bound at 10 ng/nl. Bcnoexponential eliiiaation. Serial 16-S rr oils, fasted etetniqlit before and 2 hr after dose. BBOGS; DIOPFIICS; BBiSOSEBBHT RITDODS; B10CD PUSH; UPIHE 0*6 hr cuialatife excretion after 1 • »q- Xorial 18-45 TT olds, fasted oierniqht before and 2 hr after dose. \| DBOSS; DIUSTTICS; flElSHBES!KT NtTBODS; BLOCD PUS!I1; UBI»! I FEfEFSJCE Potts, D.C. TVOI6T, T.B. 1978 Clinical Pbaraacologr and Therapeutics 23 (2): 21-26 Robbs, B.C. Tvoney. T.B. 1978 Clinical Pharmacology and Therapeutics 23 (2): 21-246 2R-1.-Beazodiaz«pin-2-one, 2B-1,a-B«nzodiazepii-2-one, 5-{2-chlorophe«fl\|-1,3-dibrdro-7-nltro- U22-61-3 C15-H10-C1-I3-03 II 315.72, IF 236.5-236.5 C TISSUE 51EO Blood 5151 Blood, plasia EIFOSOIB aottrt Ingest ioa Ingestion aUlYTTCU BBTHOD rac BalioMtry SC-EC RadlOMtrr nc BOHBIS or cis is i i niei 12-1.0 ag egnlT/sl a) 17-6.2 ag eqoif/al b) 17-1.0 ig egdiT/il IE1I lot applicable a) Rot applicable b) lot applicable G!»!B»t IIFOaUIIOR 1 and 96 hr after 2 19 of aicronized clonaTepai-2-14C, deternined by GC-ZC. Aqreed vith TIC, cadioiettr valaes. Biezeooential decline. DBOGS; IMSOJEBIIT SFTHODSJ BIOOD; iiTico»Tnts»iras: connaiTife EfaiuaTiows; BLOOD PUSIA a) Total 1»C b) 1C-clona2epan 1 and 120 br after 2 ag of licxoniled clonaiepan-2-1C BB1SS; 1EIS01ENMT HTT80DS; BIOODj UTTCOWTBlSalTS: COHP»B»T1T!! MatViTtOllS; BLOOD PU51J SZFEIEICE de SilTa, 3.1.7. fnglisi, C.T. HQnno, 1. 197 Journal of Pharnacentical Sciences «3(«): 520-527 de Silva, J.J.F. Pnqlisl. C.T. Banco, I. 197» Journal of Pharmaceutical Sciences 63(4): 520-527 ------- C t»-Bf 7-C1-I2-0 •I J2».«3, BE ts-l«« c («l«o '- CcycJopropvl.,,,!, -t,3-dl.Taro-S-pa«rl- t«-i7 q TISSUE - 5152 BlooJ. Plasaa 5153 uriw KIMSntS MBTB Iagetioa Inqwtio. 1M1RIC11 BRBOD «C «C imtat or cists — 5 - 5 flS5 i ~ I *** 1 SMERal IIFOlaaTIOf f l' S! £ gJS - B'USI * " - 10° / S rtete ?! s &:.• i .bur • « - » ?,* 3 - #= 22" ' — "• < BKK i £§••-- jg« i HI . r " 11 ! s~ ~^«rs'sr.r - 1 f) 179 * or - 33 \| prazepaa 1 ng/nl j 1 2U2i5 * ot ' " ! SESV""""'- " 56"H 9> "e 1 h) M * oc - 38 «,/.! \| 1 1 «1»»IKEPI1M5 OIITSD KH6DO1I: j 1 IBUlTSi LlfSSj D81IE! HWIBOIISI 8 !:K:S S S t5 : S : ^:S i \\ SKss-^- j \| Betabolltes In 2» hr speciieits »£tec J 1 30 •« PCazepM, * dose excreted \| 1 rasttnq non-sBoken, vt S6-«» kq. age 1 1 20—%1 yr \| 1 ' 1 BMZODttZMHES; DKTSB KIWSDOB: • 1 IMITS; ITT«; D8IIII; «W1%OIISS nrnacs Chasseaod, i.f. Taylor. 7. Eroate, E.E. 1980 Jooraal of «tariacr anl Phanacologj 32:652-653 Chaaseana, L.T. Taylor. T. Brolie. E.E. 1990 Joarual at ?karaacy anl Phanacoloqj 32:652-653 il 2B».7S. at 125-126 C Ul 1ISSOI 515* eiooa S155 Bloe4, plasu 5156 Blood. plasia IIPOSBBE tOUTE Ingest ion laqestloi Tnoestlon Jllirticu, •mcB ec . — ac sc !•• • L _ IVUBSB or ciszs 5 5 5 B1BGZ 1M-130 .9/11 225-20» »g/al 25-22 ag/al (MIT isii lot gi»«» lot given lot glTen PISE) G'llgll IiroBBlTIOi 10 «q, 2.5 hr later, 1000 1 heparln Reaaued before »ad 15 »in after teparln. corresponilnij free icnq values. 3.6-6.9 x)/al. •craal 23-»0 »r olds. IIPIUS; "BOMIWSi SBT«BOLISB: B1OOD: 31COB PUSH; i»oe I«T8E»CIIOII: CHD5S; HOSC1I PELAT1TIS 10 aq, 2.5 hr later. 1000 0 heparln. ««a«rel before and 15 aln after hcvarlft. Corresponding free droo values, J.S - S.9 aq/al. Ior.il 23-HO yr oils. 1TPIBS; PROTIMS; SET»B01IS»: BIOOD- steoo ntsui; BUDS i»TE»icTi6ii- MUGS; IUSCIE EPUltlHTS 10 aq, -1. 5 hi later 1000 0 heparln. neasnrel before and 15 .In after teparin. Cocrespondlnq free 4rnq values, 0. 42-1. 01 nq/al. loraal 23-»0 yr olds. IT?IBS: PPOMIIIS; BWUBOIISB; S1OO3: BtCOO ?t»S1S: DBOG IHTEMCTIOK; tS!IGS; IIHSCIB TIIHTiirrS — _ SlriBUCE Footledge. p.A. rltchell. S.B. IlornssoE, T.B. Sltloner, 1. llnnolla, •!. Shan a, D.G. 1480 Clinical Phar.acology an! Therapeutics 27(4)!528-532 Tontledge, ».». Kitchen, B.B. Blornsson, T.D. Skinner, T. linnoila, n. Shand, B.G. 1980 Clinical Phariacology and Therapeutics 27(»):52«-532 Toutledge, P.I. Fitchell. B.B. Bjornsson, T.P. Skinner, T. linnoila, R. Shanil, D.G. 1930 clinical Pharaacoloar a»d Therapeutics 21 m: 528-532 ------- 2B-1, »-B«BoaiazepU-2-oaa. 7-chloro-1,3-dihydro- 1-nethyl-5-pheBil- C16-B13-C1-12-0 HI ZV«. », n TISSUE 5157 Bleed, plasaa 5158 Blood, plasma 5159 Blood. plasma El POSHES BOOTE In lection Ingestiea Ingestiot UllTTICja BBTBCD OC-EC GC oc IOBBSS or CASES 2* 1 (con iaVSB at «00-2.5 mg/ml bl 290-6 ng/al c) «50-« ag/al At 520-8 ng/al e) 3.5-«7 ng/al f) 3.5-16 ng/al g) 3.5-36 ag/s.1 h) 7.7-28 ng/al a) lot glvea b\| lot given e) lot gives d) lot gives a) lot applicable b) lot applicable ct lot applicable fill! mi at lot given b\| let given c) lot given d) lot given e) lot gives ft let given gt let given h) lot given at Hi ag/al b) 97 ng/al cl 102 ng/ml d\| 76 ag/al a) 1007 ag/al b) 1250 ng/al e\| 230 ag/al rial) at Initial eeasanaent and 6 days, 2 it Initial aeasnreaent and 9 dnys, 69 yt eld male ct Initial aeasareaent and 7 days, 29 yr old female d\| Initial meaaareaent and 8 days, 62 yr eld female e\| DesaethyldiaTepaa, initial measurement and 2 days. 7.0 ng/al at 7 days, 2» yr old aale f\| Desmethyldiaiepaa, 0.25 and * days, "lateaa » 9 days, 69 yr-old •ale , . . q) Desmethyldiazepam. initial measurement and 3 days. 22 ng/ml at 7 days, 29 yr old feaale h) Desmethyldiazepaa. Initial measurement and 2 days. 20 ng/al at 8 days, 62 yr old female' 9ose. 5-10 sg. IT Sacking associated with higher clearance valaes Healthy snblects BSDGS: DltZIPMS; BEIZODIiZEPlSBS; IGI: six; MCOD Plasm; SSOKIIS: BF'BBOlISllj HBTaBOHTBS; COSPIBMTVE EVal9ATIQlV5t aDtfLTS at Snblects, high nenroticism, 1.5 hr after dose tt Controls, 1.5 hr after dose c) sabjeets, high nearoticisn, 6.0 hr after dose d) controls, 6.0 hr after dose s mg dose. Controls differed significantly at 1.5 hr. Healthy 19-21 yr old Japanese, no ether drags, evaluated for nenroticisa, dosed after aeal. rmres; as»zotnti?ii!s; sBDMtyss; HOOD P11SH1; 1DOLTS; I30BOXOGIC Hlf TF^STITIOV5; CO^PIS&TITZ IllLUflOFS; J»P" a) nay 1 of 7 days on placebo b) Day 1 on 10 ng ilazepaa «1 9ay 1* OB 10 a? diazepan tata also for H-desaethyldiaiepaa • 1 yr old dlazepaa abnser. Iisalraent of eye-hand coordination. performance la tasks requiring sustained areasal. information ctecesslng, and short tern e«sory. MUGS! StCOO Slim; HBMB01ITES; DUDS lt«S«; BHMfitS BtrUBEBCE Greeablatt, D.J. Ulen, B.D. Baraatz, J.S. Skadar, B.I. 1980 Clinical Pharmacology and Therapeutics 27f3ls301-312 Vakano, S. Ogawa, 1. Kavazn, Y. 1990 Clinical Pharmacology and Therapeutics 27 (3) : 370-37* — , — tinnoila, H. Ervin, C. ». Erendle, 1. Skinner, T. Bovtledge, P.I. 1980 Icta Pharaacologica et Toticologica 7:75-77 ------- C16-H13-C1-I2-0 •I 28. 7«, BF 125-12C C TISSBE — 5169 Blood, plaasa 5161 Blood. Flasna SK2 Hood, Plasaa 51«3 Blood, sems EXMSOtS tOOIB Injection Injection iBaestioB IB -lection — AfaLTTlCAL '""" •RHOD ac GC -- CC-BC SC or CASSS i 23 . a> 12 b) 14 7 H-U«TJ.» yea) B) 240-12.5 ng/al b) 1750-28 ng/al 0.09-2.73 ug/Bl a) 10-12.5 ng/nl b) CO-IS ng/nl a) 350-25 ng/nl b) 400-325 ng/nl c) 410-30 ng/nl dj 105-100 ng/nl •Ell a> lot aivei b» lot given 0.96 uq/al a) lot applicable b) tot applicable a) lot given b) lot given e) Rot qlvea d) lot given (•EXT PAG1) SEIEE1L IfFOBRATIOV a) Initial icasarenent and 72 hr b) Initial seasurenent and 9« hr. pro treated «ith C.O aq cisetldlne Istlnated fron graph Dese. 0.1 nq/kq. Bealthy volunteer, fasted before dose. Sedation when pretreated nits cinetidine. BMJSS; DBTJC inrSACIIOR; Tp.AiQon.itns; eissiHT; BIOOS PLASHA: SIEATITSS level required for sedation. Dose, 3-70 acj IT. Dose- and level-correlated r>0.84«, p<0.001. »»•- and dose-related, r— 0.«S. f U.wDl. Cardiac patients »lth arrhythnUs treated by elective cardioversion. C906S; BKW5 THSBIPY; SEDATITBS; BLOOD ELASflA; AGV; 88 AST DISUSES - a) Controls. Peak at 2 hr t\| Alcoholics. Peak at 2 hr •eans. 2-«8 hr after 10 ig. Peaks differed. P<0.01. 3.5-hr values differed, P 5 yr. On hypnotics and neuroleptic draqs. DiaCS ; D«B6 THIFA?!: AljCOHOLIC B1VEBA6ES; FIILAID; BLOOD PIAS«A: CCSPARATIfS JVAIOATI01S; ADDWS; vflSCLE REIAIMTS a\| Reans at 4 and 8 hr. aineral •ater given at 5 hr tl (leans at 6 and 8 hr. Initial icasurenent, 380 nq/nl at » hr. Carbohydrate neal at 5 hr cl deans at C and 8 hr. Initial •easnrenent. 390 ng/nl it « hr. Tatty neal at 5 hr. i) l-aessethyldlazepan neans at and 8 •r. Initial neasurenent, 10* ng/nl at « hr. patty neal at 5 hr tstlaated fron graph. Dose, 0.3 •9/kq diazepaa. IT. Bealthy volunteers, neaa aqe 21.4 * or - 1.7 yr, no previous diazepan eee, Finland. latique after fool 6 hr after dose. Ability to dlscrialnate flickering light not correlated •ith sernn levels. caass: ?IKLI»; BUSCLI RELAXAOTS- S10CD SB81B; CO'CHATTY* EVAlnitIO»S- »1TABO'.IS?I; IOTTOLOSIC 1AIIPISTATIOHS IEPEEERCE Klotz, 0. Beinaan, I. 1980 Rev England Journal of Bedicine 302(18): 1012-1014 tiaidenberg, a. B. Levy, H. varner, H. Continho, C.B. Sckvirtt, R.A. In. s. Cheripko. J. 1978 Clinical Pkarnacology anl Therapeutics 23(«):371-37« Sellnan. B. PeMarlnen, A. Kangas, L. Raijola. E. 1975 Aeta Pharaacologica et Toricologica 36:25-32 tinnoila. 1. rorttila. r. Rattila. R.J. 1975 Acta Ptiarucologica et Toricologica 3:181-18« ------- 2B-1.«-B.«odi.T.pi.-2-on,. 7-c.loro-1 ,3-di.ydro-1-.ethrl-5-,e.rl- «29-1»-5 C16-B13-C1-B2-0 11 2e«.7«. BI 1ISSOB 51«» Blood, Ser« 125-126 C EirosvBB looiz Injection iHLiticii. BETHOD oc-ec IOBBM or cisss 2S (coBTi " iiiG! •) 750-35 •«/•! b) 600-55 ng/al e) 25-«0 ng/nl 4) 3O-60 ng/ml IDE91 BMB a) Hot giv«ft b) Bot 9-i«n c) lot gi»en d) Bot gi»«n GEBEBll IBFOBHaTIOH a) Initial neasnreneat and 72 ht after 0.2 nq/kq. « Canscasians tl Initial measurement anfl 72 hr after 0.2 nq/k ------- 6M-7S-1 C15-I11-C1-H-02 •I 286.71. \|( 205-206 C .B-2-OM. T-CBloro-l,3-dihrir«-3-«7«rorr-S-p»e«rl- 1135(1 5167 Blood. Flasaa 51CS Brine Bifosnts toots Ingastioa laqeatioa IMtnmi RRBOB 6C-EC 6C/BS ImiBSH or cisss ... a) It b\| 20 3 BAKB ») «27-1«17 ng/Bl •) lot given b) lot given c) lot given A) lot given BE1I a) «22 « or - 37 Bg/Bl b\| 837 « or - 51 Bg/nl SE a) 5. 2 * or - 0.5* (520 * or - 50 tig) b) M.7 + or - 9.0* (»170 » or - 900 agi c) 7.7 » or - 0.5« (770 » or - 50 ng) 4) 67.3 * or - 1.7* (6730 » or - 170 og\| GEXISAt XlfOKBiTIOl a) Bei b) Voaea leaks. 2-3 hr after 30 aq, single dosd Peaks negatlvelT correlated «ith body • t »r - -0.«3. P < .01). Higher clearance also associated vith heavy clqarette snoUnq. lenlthr 22-«« yr olds fasted oveniqht and 3 hr after dose. B». aiSSACBBSMTS; BBHS: AGE; SET; ELCOD PllSBl; DCDCS; SEBA1IVES: IfAlOATIOBS: SBOKIIS a) Unchanged drag, 0-8 hr t) Conjugate. 0-8 hr c) Onchanged drag, 0-24 hr S) Con1«gate, 0-2» hr Dose. 10 nq JIPll; BIOOB PllSPU; OBIIE; DRBGS; — — BEfEBElTCE Greeablatt, D.J. Bivoll, 9. Rarafttz. J.S. Shaier, B.I. 1980 Journal of Pharnacologv and Szperineatal Therapeutics 215(11:86-91 Biqnchi. S. nrabe, g. shlobara. T. 1979 Jonraal of Chronatographr 16 «: 55-61 ' ,3-ai»Tdto-5-phe.rl- C15-B11-C1-1J-0 1« 270.73 -P- •vj vd HSSOS 5169 Mood S170 Blood cirosoB. ionii tigestlon laoestlon iiiLnicu. RTBOD ec . — . - niBEt OT CISZS S - 1 15-H U9/«1 — — , •ot give* (KIT HB1I lot glYeu 0.7« ng/al PtSS) SilCUL IIFOSfllTXOI ~ 10 wj. 2.5 hr later 1000 B heparla. fcasurei before and 15 Bin after aenarln. Cocrespooding free 4ruq values, 0.62-1.01 aq/nl. Iccaal 23-«0 yr olds. IIPIBS; p»oiti»S: SEnioiisa: BWOD: StCOD Pl»S«»: 9»BG IKTSFlCTIOJ; HISS: aoscii BEL»S»IITS - ivtopsr saeple «< jf old pharmacist, suicide. cverdose of other dcaqs BSBSS; 9B!JG 18HSI; SUICIDE: itnopsits; CISF Bisiowfs; llSSOSSHIilt METHODS; \|EW ZE»1»1ID' "5"' 11T'! »P1IIS! itmaETsj BBHM: SL CO BOL5 IEFEIERCE - Soatledge. p. A. rttehell, B.3. Bjocnason, T.O. Skinner, T. Hanoi la, n. Shand, D.G. 1980 Clinical Pharnacologr and Therapeutics 2T(»): 528-5 32 Oaeree, E.I. Clckson, S.J. (lissen, ».». Pannell, 1, it. 1979 Journal of Inalftical Toiicaloqj 3:253-255 ------- 2B-1.a-Be»«>«iaz«pli>-2-one. 7-ehloto-l .S-dihTaro-S-phenjl- lflM-11-5 C15-B11-C1-I2-0 11 270.73 TISSUE 5171 Blood, 5172 Blood, nlasM . •173 Blood. plasna BIFOStllE ROBTI Inoestlon Invest Ion Ingest ion ISAI.TTICAL BETHOD GC 8C-BC «C-BC BOBJM OF CASES " 1 8 " 12 (CORJ JAKE a) lot applicable b) lot applicable e) lot applicable — " 759-37«8 ttg/1 72-16S ng/nl BUEDI a) UOO ng/al b) 990 ng/nl c) 3110 ng/nl . Bot gi»en 138 »or- 8.8 ng/nl SE GEBIBA1 IBFOBHATI01 _ ' ~ a) DnT 1 of 7 days on placebo b) Day 1 OB 10 ng diaiepaa e) Bay 1« OB 10 ag diazepaa M yr old diazepaa abnser lapairaent of efe-haBd cooraination . cerfornance in tasks requiring sustained arousal, infornation processing, and short tern nenory. EB06S: BLOOD SMBU; BOTABOLITES: DUOS IBOSE: 9IAZMMS Rean steady state values after 1.0-3.1 nq/kq. lEllepsy patients BICBTS11; HBBfOOS SYSTEM BISZASBS! nooo: BIOOB PLASM: IBTICO»WLS»BTS! CBBB THESMTs BKOSSi TaMOKW««»S IB tI»«O »«1IISIS: SEASOBEBEBT BITHOBSi BMtOSIAtSSHBS Peaks, at 2.S-72 hr (nean 13.1 hrj after 20 ng irazeoan. Eealthr 22-«2 Tr olds, »t S6.8-88. kg. Tasted before and after dose. SB1SS: DIAZIFAHS: BEBZOBIASIPISIS; USE- SBf! SICItJIS: BIOOD PL»S»AS BITABOLISB: CO1?ABATI« STAtBATJOBS 1 SETBRBirCB < linnolla, B. Ervin, C.B. Brenlle. A. Skinner, T. Foutledge, S.A. 1980 Acta fharaacologica et Toiticologica HI: 75-77 Paidnke«7ch, D. Bodin, B.A. DaTeaport, F. 1980 Clinical Chenistry Allen. H.D. Greeablatt, D.J. Haraatz, J.S. Shader, B.I. 1979 Journal of Clinical Pfcaraacology 19!«as-a50 00 0 ;: ?3L«S=ffiMZ'^^ -. C15-BIO-C12-B2-02 81 321.1«« Hf IISSDE 517« Blood. plnsna 166-16* c HIFOSMB BODII IB-tectiOB Ing«tion aiURicii RETROD 8C-BC BOHflSl or CASES 10 — BABSE^ n) 17.6-60.7 ng/nl b) 18.0-36.4 LJ/al • " IBBIT — BEAB al 38.»2 » or - 13.25 ng/nl , „ b) 28.85 or - 6.13 ng/nl US I) • — a) Peaks, elderly. Peak tine, 0.9" » cr - 0.19 tst) nr after 1.95 » or - 0.83(SD) ng orally, 10 subjects M Peaks, elderly- Peak tine. 1.03 » or - 0.16ISI) «r after 1.85 • or - 0.7a(S01 nq IB, 10 sublects Seae data for TT doses. Bcalthy 60-8« tr alas, vt W.s-111.« Crovsiness. sedntion. sleep for 1 to 6 fcr. tBOSS: 111IIOtIA''WItBS: A6t: BtOOB I1AS1A: 1«Ilti SBOKItS; COISABAtlfB ItAllATIOBS Wrssnct Greenblatt, tt. J. »11«B, B. 9. locslskar. A. flaraatz, J- S. Staler, P.I. 1979 Clinical Pharaacology and Therapeutics 2e(1)s103-113 1 . ------- C1S-B10-C12-12-02 •t 121.i«. n 166-168 c TISSUE 5175 Blood. Plan* 5174 Win 5177 nrlae nmssn torn lageatioa iB-Jectioa lageatioa auinioii HFfBOD QC/IS «C-IC ec/is OF CUES 3 9 3 BIB6I a) 28-6 i,/.i b) 18-1 ag/al ) lot give b) Bot given e) Bot gl« _ a) Bot given b) Bot given e) Bot give d) Bot given BSaB a) Bot given b\| Bot given a) 835 of dose b) 801 of done c) 67V of doae a) 0.10 « or - 0.02 «1-5 » or - 0.3 ng) bj 26.1 * or - 3.6T (391.5 » or - SO «g\| e\| 0.59 * or - 0.2t (8.85 » or - 3.6 «g\| dj 68.3 .or - 5.2 (1024.5 * or - 78 eg) CEBEMt momTIOB ".•'i!? of ***** anchanged drug. 2 and 2* hr after 1.5 aa. Initial BCBBweaeBt. 2» Bq/al at 1.5 hr '"? °f aean«, conjagated drug, 3 !««£ ht :fttf 1>S '«• I»itial acainreaeot. u »g/«i «t 1 hr tatinated fien graph. «P1»: BtOOt FL19U; 01IBE: tSOGS; inllQUttltCTS ; HE1SOB? BEHT HETEODS a\| IT II Oral c\| In 72 br emulative excretioa of glncacoBlde in elderly vol.nteers. lecoasted for 80-90 of totnl clearance. Browaineas. sedation, sl^p tm , to «B8S: BinOBIKEPIBBS: iSE; BLOOD * DBI VE$ SHOK3V5 : COHPIBITTTE a\| Onchaaged drag. 0-6 hr >) Con1«g>te. 0-8 hr cj OBchanaed drag. 0-2« hr «) Conlvgate, 0-2a hr Ccae. 1.5 eg IBIVQUmms; BEtSOTESEBr'aWFODS BETSRBBCB Rigachl. s. Orabe. B. Shiobara. T. Journal of Chroaatographr 16»: 55-61 - Greenblatt, B.J. Allea. B.D. Locniskar. 1. Haraatz, j.s. Shador. E.I. 1979 Clinical PhireacolooT and Therapeatlcs 26 (IJs 103- 113 fligachl. S. Qrabe, E. Shiobara, t. 1979 Journal of Chronatographr 00 CS3-B31-I-O2 M 353. •». Bt 193-217 C „ iissm 5178 Blood, flaaaa BHOSms 10011 laqestlon BITHOD rants or cisss BIBGB a) 0.023-0.118 ««/•! b) 0.055-0.193 ao/al c\| O.OST-0.123 nj/al at 0.060 og/ml b) 0.1ia »,/,! e) 0.069 ng/al I»FOBH»TIO» •» »J«tTlaet«adol. Peak at * hr. 0-a«d »»-hr. none detected II lorieetTlaetaatol. »ealc at a-8 hr. Oatectatl. «t 0 aad »8 hr cl BUoracetTlaethadol. Pl.teau at hr. Only sliqht teclUe at «8 hr B«»a males .fter «o-«» «,. 72 hr after preTlcm doae. »4 ------- 3-BeptanOD«, C2'HB27-1-0 81 309. »9 TISSUE 5179 5180 Mood, 5181 Blood, seres 5182 liver BIPOSOBS SOOtE legation Ingest Ion Ingest Ion Xagestion 1I1LTTIC1L BSTHOD GC BIl •MBSE or CISES 1 a) 6 b) < a 1 ««ISB lot given a) 138-220 ng/sl b) 311-580 ng/nl 32-7.3 ««/•! Oeoeatrlc •cans lot given (HIT 0.36 ng/nl a) 182 ng/al b) "20 ng/l lot given 19 ng/g MSEJ aatopsy sample II yr old pharmacist, suicide EBOG5: BBIJG IE9SI; SUICIDE; 10TOPSTSS: CIS! HISTOSIES; qiaSTBMMT BETHODS; »E» ZT1UID; BtOOD; U»W! UP HI; KIDIEIS; BRall; I1COBOLS a) lean daily levels vith maintenance dcse of »0 tg/day. Level before dose, 116 nq/nl t) Rean daily levels »ith inintenanoe dcse of 80 »g/d»y. level before dose. 2(5 ng/»l qenoexponential decay. 20-37 yr olds, fron Tt State Drug abuse control coulssion. Oa«d heroin S-22 yr b«t, no druqs for 2-8 •onths. fo Increased niosla. BM6S; BIOOB PLiSMj TJSIIE: ISCES: tt» TOSI; C05PiR»TITE ETaLOKIOSS: asiiBoiisiij srriBOiiTss 2 hr an! «8 hr after 15.2 » or - 1 • g/kg/1.79 sq body surface area. Initial neasnrecent, 28 ng/l at 1 hr Estimated frcn graph. Healthy, nonpregnaat 21-29 T' oUs, In folllcalat phase of secstmal cycle, on. Hethadone-indnced respiratory devres«lon and nlosis lasted > IS hr. Staadv state ventilatory response carve for CC2 inhalation «as Usplaeed, and papillary constriction Increased. COZGOl; atttlTS: BIOOB rZEOS; IttlSSSTCS; CBOSS; BOB ROUES: ii?eoTicS) ii TITO tiiirsis; 1 yr old pharcaclst, suicide DBOGS : DRUS UUSE: saiciDi; IOTOPSHS; CiS^ HISIOBI5S: BtOCB! tTVS?: DBHJ: «B«ETSS Bsil: iiccnoi-s " BEFEBeBCE Oaeree, E.I. Dickson. s.J. Rissen. 1.. Pannell. l.K- 1979 Journal of analytical Toxicology 3:253-255 verebely, K. Tolavka, J. Rale. s. Besnick, B. 1975 Clinical Sharsacology and therapeutics 18(21:180-190 olsen, G.D. vilson, J.:. Robertson. G.E. Clinical Pharnacology and Therapeutics 29 (3): 373-3 60 Queree, S.a. Dickson, S.J. Pannell, L.K. Joarcal of analytical Toxicology 3:253-255 CX> NJ ------- c:i-§27-i-o Bi JM.tf TISSUE - 5183 Or ice izfvsnn SODTE T rtlon lIUTTXCal HBTBOD nriBn OF C1SKS C ~~ iiiei " — a) 13.2-25.3 X of doee b) 28. 9- 60. « X of dose (COITIIOID) B) 19.16* Of dOM b) «1.M of dose CH-B20-I2-02 M 308.37, IF 105 C PIH«L •1 tfter single «0 or 80 no dose. 3" erereted as pTrrolidine ) Chronic •tlateuaca dose o» »o or 8« •g/J»T. ««f ercretoj as 2«-hr seines. 20-37 Tr olds, from It State Drug 1!>VM coatrol Coamisaloa. Use! for 2'8 >o increased iloits. "ires-. BICOD " «>«« BRiBOtltBS DS«E: IECIS- IT.LHllaiS BEPEfiEITCE K. TolaTka. j. Hale, s. Penick, B. 1975 Clinical Phutacologr and tberapeatlcs TISSUE 518 Blood. plnsna BXPOSmg tOBTE1 Ingeation aiunicu. IETBCO ec BOBBEB OF CaSES < 1 1 ~~ iliei a) 12.48-17.05 ag/il ) 30.77-«(.33 ag/nl c) 51.18-88.11 ag/nl UtB -- »» ;»•« «,/.! b) 38. ai ag/nl c) 75.20 ag/nl 6BIEBAI IIPOBMiTIOR " """"" a) Ifter 100 M t) after 300 nq c) Ifter fOO nq Peak lorels Bealthr 23-29 vr olds. Trance ^*CE: 1DOLTS; BLOOD PLaStta; FEFSSE9C2 Sioofi. ». Colossi, D. Caudal, T. Schoeller. J.r. Hasslas, P. 1980 Journal of Pharmaceutical Sciences 00 58-25-3 C16-B1-C1-I3-0 !I 299.75, BP 23C-236.S C .e- TISS1! - S18S Clool. Flasia MPOSUEE 100TC lalection IMITTICU BfTBOC - BPIC HgSBB OF CISBS 5 a) C500-200 no/«l b) 6800-180 n-j/al c) 0-1000 ng/al d) 0-2000 ng/nl lot given Hot given Rot given lot given (fEIt pact) » A J "•»». 1 "« 30 hr after «.n. 1980 Enropaan Journal of Clinical PtarnacolwiT 18:275-278 ------- banrl-. «-oxid« IB CI) .-. -oxid« \|9 CI) St-25-3 It 2OT.75. 1 113301 s«6 Blool. pla«M 5187 Bleoa, ser» 234-23. 5 C HMSntS BOMB IB Action Inlectlon I notation kMlTTICkl HETHOD Ha imsn OF C1SSS •I 11 H 11 c)7 a (COIM •" ilies •} 3.6-0.03 »g/»l b) J.6-0.16 ««/»l e) 2.0-0.2 o«/»l — ' at 1.0T-1.TT «g/»l b) 1.00-1. SO »g/«l c) 0.2»-0.8« «9/«l d) 0.20-1.15 ag/»l •USD) SB»1 a) »ot applicable b) lot applicable c) lot applicable a) 1.32 «g/«l b) 1.»2 ng/al c) 0.56 «g/«l d) 0.«« ug/al — SIStHL IITOBIMIOI ^ ~ •1 Hen c! •«••£ on oral contr«ceptlT«s !«.,« of «a««. iBiti.l .e.s«r«»ent ail 56 hr after 0.6 iq/kf. IT. Il«rpoii««tial elUlnation. 17-39 rr old »n. 21-«2 yr «W «ro»«B- J«-29 it oW «o««o. o« or»l contraceptive > 6 •« 111 norial. BHZOtliZroHIS; DS06S; OBll ecm»c5wt«si irnnts: s«i: BIOOD Misa.rww»»"« w""0"8' §M»EOHSB: miHK a) 1 hr aft«c oral lose il 2 br after oral dose c) 1 br after I" io»e i) 2 br after III flose Do«e. 2? aq a« hTar««"oria«- CealtbT «en, t»stln:«28-831 Gottschalk. 1- I- Biener. 3- DinoTO, B.C. research Coiaanicationa in Cbepieal Pathology anl fhaciacologr 8(1) :697-702 oo 2S232-5»-8 C7-B10-I2-02-S Kf 186.23, « fissni 5188 Hood. •ecu S1OT •ilk E 122-125 C "EHOSOH ioo« Ingestlon _ tB^estio* _ — . — immcu. 9, J. Alexander, V.D. 1979 lancet 2(8150): 1011 ------- SSSSSSfc JC«e«-S6-2 «S«-H27-Cl-f5-«-0 II 523-99, W 105-107 C te ^ \| lISSQt 1 1 I 5190 I 11004, \| DlUia s 1 1 1 1 1 1 1 EIPOSOH IOWE Tmqestioa 1 « tmnicai. nSTBOB SC-BC I I i __ •nun or cisss •I 7 W e c) 8 I I I EIIGI «) 3.75-9 «9/»l b) 6.25-12 »g/l cj 8.75-25 »$/•! 1 1 1 1 1 1 1 BED al 6.25 »g/»l b) 9.2 ng/ml c) 18.75 ng/»l 1 1 1 1 I at 30 «q weekly b) SO iq »««1ilT c) 120 «q »e€lT •tealT state leTela. «sti»ated £ro» cr&ph. te»«ls corr«latefl «ith Sose. r-0.81. ?<0.05. Bcspitaltiea 27-59 Tr oli sckiiophcenics in qooi phT«ic»l 1 k «»s. 13-15 hr after 250-aq 3 o:"o 5/S i «b^». »-« kr •«« ~ "°-ti S oil! 3/S • ^5- 2™ hc a£t" fo"r 250"9 ! «fcpeas, 12-28 «r after «ll tablets 1 e) teatv 8-12 hr after 500 wi in i \| aqaeovs suspension. i I tolnnteers, 21-»5 yr old. dosed 2-3 1 ht after llqold, 360-calorle I tteakfast. \| CSBSS; liTTBIOTICS; »B01TS; BLOOD; I USISICT Of COMBBII; COHP»SITIT! 1 IW1WITI01IS: I»ECT1O 1 __ Cesjardins, B. E. Eaaplin. C.L. »o« 3re4o«, 3. Sarry, K.G. Canfleld, C.J. 1979 clinical Pharaacology and therapeutics 26{3):372-379 , . ., i 1 CX3 ------- ,-Thi.-1-«.cicyclo(3.2.0) h.pt._e-2^.rbo,ylic acid. 3.3-di,.t.,l-6-«C n3-\|^l1Tl..lfo.,l\|-2-O«-1-i.iaazoUai.rl)<:«bo,Tl)a.l««)Pl.«TlacetTl) .a»o)-7-oxo-. <2S-»alpha.5alp_a.6beta(S«)))- 5181-65-3 C21-B25-IS-08-S2 II S39.63 1ISSOB 5192 Blood. plasia 5193 Blood. 519» nriae EXtOSOBE 800TI Injection ' Injection Inaction 1I11YTIC11 BETHOD Bicrobiological Microbiological Microbiological BOB BIS OF C1SSS 27 10 10 MIGB a) <1-253 or - 129 »g/l b) <1-20« » or - 81 ng/1 c) <1-252 * or - 75.4 •g/1 d) <1-23» t or - 66. a •g/1 a) lot givci b) lot given c) lot given d) lot given lot given a) lot given b) lot given c) Bot given d) lot give* a) 30. * or - 56.2 •g/1 b) 78.3 * or - .7.1 •g/i c) 7.2 * or - 2.5 •q/1 d) 0.22 * or - 0.17 WJ/1 53.9 * or - 8. SOU of dose a) sableets »ith creatlnine clearance greater tlan or equal to 60 al/ain t) Sableets «ith creatinine clearance 30-59 ml/ail) c) Snbleets ith ereatlnine clearance 10-29 nl/.in d) Sttbleets with creatinine clearance <10 nl/ain Bange of neans over 24.5 hr Ifter 30 ain IT of 3 g •Idolts with varying renal function. age 32. » » cr - 11.5 to 57.7 + or - 21.5 yr, Indiana. immil; aTHlITS; KIOIBT DISUSES; BICOB SUSHI; HTiBioTics: DBOGS: CC"!?»H»TITE iTAin.IIOWS a) 0 hr b) 1 hr c) 4 hr d) 1C hr Ifter 33 Bin IT of »000 »g. Values adlusted to 70 kg body Height. Bealthy 20-H9 yr olds, »t 66.9 » or - £.0 kg. CIDeS; DUOS IBIE1PY: HTIBIOTICS; HOOD SSBDS; U8IBB; GJBMST.; UTK-IOB: CCBP1BITIT! BTitO»TIO»S: jtnws 1 0-2« hr atcretion after 30 nln IT of (000 aq. Bealtby 20-49 yr olds, »t 56.9 or - 6.0 kg. BFOGS: nans THISIPT; irpiBiorics: HOOD 5!Sni: DUIE: 8339111; IS«I«IO»; CCBP»B»TIT? BTitHlTIOS: — - Ironoff, G.B. Sloan, B.S. 10ft, F.C. Belson, P.I. nanell, D.B. Ilelt, S.i. 1980 Clinical Pharaacology and Therapeutics 28(») : 523-528 Lode, H. Toaas, «. Foeppe, P. Wagner, J. 1980 chemotherapy 26:81-90 lode, n. Toaas, V. Foeppe, P. eaqner, J. chemotherapy 26:81-90 oo ,-,hi.-1-.»«CTClo 13.2.0, n.pt.-e-2-c.rboxylic ^id, 3,3-di_^hTl-7-«o-6- «((,(2-oxo- 1-iU..i.lUt.,l\| carbonyl. a.im,,pbenylacetyl,a.ino, -. (2S- (2.1Pha.Salpha, .beta (S«,,, - 37011-«6-0 c;0-B23-IS-0€-S at ««1.5« TISSOB 5195 Blood, BTPOSOBS IOD1E Tnlection numcii RET BOD licrobiological IDICBB 07 C1SIS 7 BHGB 260-17 ng/l BE1B lot given CIIEB1L I»rO«»aTIO» deans, 5 iln and 0 hr after 2.0 g, I«. Continuous biezponential decline. •stiaated frcn graph. 22-72 yr old henoiialysis patients, lost with end-stage renal disease. Dew Turk. HOGS: viTnioncs: BIOOD S^PBI: KIB1IST »TS-«SIS; HEIIOMilTSIS: 1CT ICHK BEFEB!I!CE Aletta, J.!!. •eu, B.C. 1980 Clinical Pharmacology an] Therapeutics 27 (»): 563-566 ------- 2.0J b.pt...-2-c.EboiTUc o.,l\| a. C2S-B2S-I6-0«-S HI CTO.C3 BRBOB Ot CaSSS .1 lot qien ) 35.0 or ~ 5-5 •t1l£ XB^ftCtiOA HlCTODlOlO^iCetl •» • tjjfc 4v«k BQ/1 Blooo. CJ «ot ii,«, b) 102.5 OE - 21.8 ""' «> 10t «1'- c?'lO.« * or - ..3 d) 0.92 » or - 0.50 nq/1 1 , ' ' ' i i i _ — i • 5197 Lotion 1 Slcrobiolooical \| 10 1 »ot qlyen 32^ * or - «.3« of urine I , ' 1 1 1 I 1 1 1 ! ! ._ . i , ... -' j ;i ? s i --»."• e> 1 nr ' X0™' p- Ifter JO .in W of WOO «q. Talnes 1 "^"^ ,6.B,-90 ad1iiste4 to body t of 70 Kg* i *° " i 1 sir loos infections caused bj Bay 1 1 «-senslti»e orqanisns. Seraany. 1 1 " 1 Soft stool, aiarraea. nausea, eaesis. I \| headache, vectiqo. exanthe aatoas 1 1 rash, Secreased thronbocytes. 1 1 exhaustion, tachycardia, aeteorisn. 1 I 1 tBOGS; D«US TBBB1»I: »«lBIt«ICS; I B100D SB3WI: DBIIB; SESSHt: J IITBCTIOIl! CCBSHatlTI BTaLOWIOTS: 1 — ____———— \| 0-2« hr excretion in healthy suMects I Lo4e. H. alter 30 »in IT of »000 nq. K«Bpe P. I wealthy 20— a9 yr olds, wt 66.9 or - Waqaer, J« l-sensiti»e orqanisns. Germany. Soft stool, diarrhea, nausea, esesls, headache, Tertiqo, erantheiatous rash, lecreased throsboeytes. exhaustion, tachycaraia. neteorisn. MUSS: DUOS tHIBlPT! HTIBI01ICS: I1TICTIOI: CC»?»BaTIT! STalOWIOBS; UOtTS 1 1 1 1 1 1 1 1 1 oo -j 6.\|nt(^thyl-2.3-dloxo-1-,iSer.xi.yl,carbo,Tl)..i.o,phe.,lac9tyl,a.l,o,-3.3-di«thyl-7-oxo.. (2S- ,2alpha.5alpha. 6beta (S-, „- 6H77-96-1 CS3-B27-15-07-S Rl 517.«1 IISS5B 5198 Blood, sernn SttOSOBE BOUT I In-Veetion alalTTlCal BETHOD Bicrobioloqical 1 I BOHEEB 01 CaSSS b) 6 IUGS b) 353-22 uq/nl aim a> lot given b) lot qiven al Beans. 0 and 270 ain after en4 of 30 nln IT of »q/8 hr. day 1. Day » peaks -lignificantly hiqher t) leans, 0 and 270 ain after end of 'a nin IT of 6q/6 hr on day 1. Day » oeak, »10 uq/nl »9ainister«a as sodiua salt licalthy 18-50 yr olds, within 10* of Heal lit t«1SS: 11TIBIOTICS; B1OOO SEBU1: Catra, T.K. "orrison, J.X. lasseter, K.C- 1979 Clinical Pharnacoloqy and Therapeutics 26(1) -.H1-53 (IEIT IGI) ------- «177-9«-1 Ci3-B2Vi If S17.«1 acia.6-,«,(,-«t,,l-2.3-diox0-1-piP«..i.,l,«:arbo.vl,..i-o,phenyl.c.tn.»i.o,-3.3-di.ethyl-7-oxo-. (2S-«2.1pk..5.1pha.6»>eta ,.,„- IISSOI 5W9 OriM siposraB IOOTI IB-faction aliLYTXCU, RETHCD Sicrobio logical IOHBBS or CISBS £ cuei ) 89. 73-80.05 of dose b) 66.92-8C.9S* of oo«e a) 76.03 + or - 8.98* of low b) 73.02 * or - 7.15* of dose Jm, B . — — — — » Day 1 C-8 hr cumulative excretions at tor 30 •In TV of »g/8 hr Bcalthy 18-50 jt olds, nithin 10« of Ideal »t tSOGS: SHTTBIOTICS; BIOOD SBBOS: OMR; CO»P»8lTI»B BT113AIIOHS FZriBEHCZ Batra, T.K. Morrison, J.I. lasseter, K.C. JOT, v.l. 1979 Clinical Pharaacologi an! Therapeatics 26(1)s»1-53 26787-79-0 (beta-lap»thale»es«lfoii«t« trihvdratej IISSHE 5200 Blood. plasma 5201 Blood. sens 5202 Flood. 5203 Bilk EUOSHRS BOOH Ingestion - - Injection iBqestioI Iaq«tlon aiumcu RB9BCB . Sierobiological licrobioloqical lOIBSB OF C1SSS 8 6 6 a) 0.9-0.1 ug/Bl b) 1.8-0.15 og/al c) 3-0.1 ug/»l a) 86-332 ug/il b) 57.7-19,3 ug/Bl e] (5.6-14.8 ug/al 7.0-1. « «9/al 9.10-0.81 og/al a) lot give* b) lot given c) lot givei a) 11 » or - 26 og/sl b) Not gives c) Rot given tot givea lot gives ..._ a) iBtaet prodrng, sethoij»etliyl «tt«r. at 0.5 and 1.5 hr. Initial value. 0.12 ng/Bl. Unspecified dose if prodraq I) laoricillin. at 1.2 and 8 hr. Initial value 0.3 uq/sl. Unspecified dese of pcodraq C) laoxieilliD. 1. and 8 hr. Initial value, 0.1 nq/al, unspecified {ese of anoiicillia lstiaat«d frca qraph. I1TIBIOT1CS: BL009 P1»S»1: ccapiviTifi EV»LO»iio»5: BBTIBOIISI; rces «) PaaVs. P«ak tine gear 5 ain b) 30 anl 20 (in levels, arterial serua C) 30 and 20 ain levels, venous lft«r 1 » »a aaoxicillin IT at start of 5 he dialysis 17-7* vr olds. »t «3-6B kq. vith renal insufficiency. riiics: ttTiBicrics: DISE»S»S; SIOOB SI501; ID HITS 1 and 2 hr after 1 g. final icasnrenent. 9.3 nq/al at 3 hr 1>-288 00 00 ------- , Iboat $ br nul4 »«rr T CkroBle circhosla patiaata BIOOD SBSOS; "«"' a) Fatleat 1 b) PatUat 2 c) Fatlaat 3 5 of 150 bT costlwous * SLOOD SSBn8! a) Cirthotlcs. 542-639 aq IT t) Conttols. .boat 600 a? IT .«, act aaasaall iapalt«a. loona. f.sted mo^r"1'"' '-''-""tbn-. dichloria, t12-B1«-.2.2Cl «1 «08. HP 300 c (teeo.p) le.is. s.S. Jasko, w. j. 1975 Clinical Pharaaeologr an! Thetapentics lavla, 6. t. Juslo. B.j. 1975 Clinical Pharmacology a»3 Tberapeotics EooTet, s. Gilbert, c. Ganleboot, C. faction, p. 19«o British B«iical Journal 280(622«)s1l6»-iis? 00 S.p. Jnslto, v.j. 1975 Clinical PhacaacologT and Therapeutics 18(«):475-«B« TISStJt 5208 Biooa tlPOSOSB ROUTE — Inqeatloa . aiuTtfcii RITBOD Colortaetcy ROHBES OF C1SIS a\| 1 b) 1 c) 1 aiisi aj lot applicable b) lot applicable c\| lot applicable a) l.t pp. b) 3.7 pp. C) 19. » pp. '" 3 ht hr r«»: BIO°D; TO1"5 S03CTDE; TTSTOBIKs MSTHMUKOS BEFZIERCE ... Orost. S.H. Dome. J.d.c. ------- -, 4ichlori«» 1» 10-42-5 C12-B14-M.2C1 t» 408. IP 300 C (decoap) (COITIWUED) J9-B32-014 1 €04.81 «SSBE 5,0, BOWB IIIMMCU, BETBOJ) C.lorl.etrT IMB™ OP C1SSS 'GEH11I. IBFOBBaTIOB C) lot .. f, „ g »' a) 25 rt old (an 3 hr after inqestion '" -0'" 2* te '"« „„ .„.„ 5 hr aft« for days 1-7 for ,). Talnes PISTICIDBS; B1OOD: BRIIS: SBICIDE; CISE HISTOBIIS; IBTHEBIMBS i-B«eth»l«PiPOdophyllotoxin ethyliaeiw-beta-B-glaeosida 1ISSQB S210 Blood. Tlana 5211 Cerebcasp inal fluid EIPOSHBI BOBTB Inj«etion Infection 1UITTIC11 RZTBOD Balloietrr BaiiomttT BBBSBK or ctsss I1B6I 2. 31-45. 88 ug/al 0.015-0.13 «g/al 31.11 ng/al lot applicable teaits, after 1 hr IT of 363-50 mg. tritiatel dose. Bierponential decar. lonresponding cancer patients, aqes •1-63 ye, ith adequate renal function, 2-8 1t after preTions ch««otharapT. shite blood cell conn decreased 0-63* at da? 8. MOSS: MIS TBWAOT; CBSHOTBIEHT; ««CPt»SlS: EtOOD P&AS11; CMEBSOSPlml F1BIB; TECM 2-26 hr after 1 hr IT of 363-130 aq, tritiated dose. Rourespoadinq cancer patients, aqes «1-S3 TC. «ith adequate renal function, 2-8 v* after prerions clecetharapT. «ite blocd cell count decreases 0-63* at dar 8. BSBSS; 1SOS IHER»PI; CH!HOTHES»Pt: ifcpusis; BIOOB ptusai: C«EE9tlOSPT!l»l FLOID; TECES »an Bij, ». KUl. Yi ' Do«e. J.B.C. t. l.S.P. 5 of Toxicology 31:129-136 I I SEKSEBC! Crearen, P.J. alien, L.a. Clinical Pharmacolo^j and Therapeutics 18 (2): 221-226 Createn, P.J. Allen, L. fl. Clinical Pharaacology and Therapeutics 18(21:221-226 ------- ^^«^«5-!, 5212 Mool. vlasna Iigeation nc tellometrr ec/HS »> S.52-U.71 > 2.68-10.22 ng» c) 2.06-9.17 ng/«l «• 8.72 » or - 1.4» 13 * ot - 1J» u . or - 1.05 (SI) a) Peaks 21-«8 Tr oia«, Biciigan Iberts, 7.5.. Jr. Pbiloponlos. B.S. Feineke, I.g. »lick. S.B. 1981 Clinical Pharmacology ana Th«npeutica 29(1)! 81-93 ------- 5-Thia-1-«abicyclo(«.2.0)oct-2-ene-2-carboxyllc acid. 3-(((5-Mthyl-1.3,a-thiadiazol-2-yl)thio)i«tliyl)-8-oxo-7-\|2-(1B-tetratol-1-yl) aeetanido)- (8 CI) 5-Thia-1-aaticyclo(».2.0)oct-2-ette-2-c«rboxylic add. 3-(((5-iethyl-1,3,«-thiadiazol-2-yl)tbio)Bethyl)-8-oxo-7-((1S-tetraxol-1-ylacetTl)aiino\|-, (6F-trans)- [9 CI) C«-B1»-I8-O»-S3 RS «««.5, «P 198-200 C (CORIIISD) TISSDI 5216 Orln 5217 OtiM EIPOSUSS BOOH Injection Inflection AEALYTICAI, BETBOD Rierobiological EPIC IDHBEK OF CASES IS 6 HISS a) «1-7M of dose b) 17.3-56.2 of dose n) Bot given b) lot given c) lot given RE1I a) Rot applicable b) lot applicable a) 801 of dose b) 51 + or - 8t of dose O 83 * or - It* of dose GEXCF.II. IIFOBRiTIOR a) Controls b) Breiics emulative excretions »-»8 hr after 500 ig 11. Data also for iiltiple doses* I loriai 25-»0 yr olds. »0-73 yr old ureiic mi vith cardiac and renal diseases. rBBGS; ABTIBIOTICS; BLOOD SEBUR; DSIIIE; ADOL1S; DISEASES; CORPABAtXTE IfllBlTTOHS a) Freoperative, 1 snblect t) During surgery c) Postoperative 5 hr emulative excretion after 7-10 •in IT of 1 or 2 g (exact dose not given) . •8-71 yr olds. 52.7-197.S kg, »ith cardlopnlsonary bypass surgery. EfiUGS; ARTIBIOTICS; REASOBEHnT RITBODS: DBIIE; BLOOD SEED!!: ADOITS; SDBGEBT: BII5T DISEASES: COHFABATIYE tTAIOATIOHS 1 BEFEBSRCE I Belling, P.O. Craig. t.A. Anidon, G.L. Kunin, C.R. 197» Clinical Fhariacology and Therapeutics 15(»):3M-353 Riller, K.s. "ecoy, B.C. Chan. K.K.B. Fischer, E.P. lindsay, V.G. Seifert, B.D. Zaske, D.F.. 1980 clinical Fhariacology and Therapeutics 27 («): 550-556. 5-Thla-1-azabicyclo(.2.0)oct-2-ene-2-carboxylic acid. 3-flirdroxy«etIiyl)-»-o)B>-7-(2-\|2-thieBTl)eetamido)- acetate (ester) (3 CT) ;-Tkla-1-axatieyelo(«.2.0)oct-2-ene-2-earboxylic acid, 3-({acetyloxy)Hthrl)-8-oxo-7-((2-thienylacatyl)anino)-. (CD-trans)- (9 CI) 113-61-7 Cie-H16-I2-oe-S2 BB 396.«» NJ llSSdl S218 eiood. serai 5219 Blood, sent EXPOSURE B001I Injection Infection IIILTTICII BETBOD BPLC Bicrobiologlcal »0g BEX or cisis i « J1IGE a) 60-12 nq/al b) 100-23 ug/nl c) 30-3.7 ug/nl a> 1«.5-7.7 og/nl e) 68-1. 5 ug/al f) 9.0-1.H 09/1! 5.9-0.7 qq/tl - HEIR a) Rot given b) Wot given c) Rot given d) lot given e) Rot given f) Rot given lot given GEItBkL IRFOSIUTIOI a) Cephalothin. day before surgery t) Cephalotkln, day of surgery c) Cephalothin, day after surgery d) Deacetylcephalothin, day before surgery e) Deacetylcephalotbin day of surgery f) Deacetyleephalotliin, day after surgery 30 and 120 sin after 2 g cepbalothin. IT. Other patient data available. 5« yr old patient. «t 8» kg. cardiopulsonary bypass snr'gery. CBtISS; TODS tB!BA?T; IRTIBtOTICS; »IOOD SEBHH; BElSTOJIJirT HMHODSj SntGIHT: NNIB01ITES 1 and 1 hr after 1 g Vange a! leans iruLTS: Bioct s»soi; BTIK; 11TI3IOT1CS; DBDGS; HCTWIOB BEFE5ERCE Killer. 1C.». Chan, K.K.K. McCoy, H.G. Fischer, B.P. lindsay, U.S. Zaske, D.E. 1979 Clinical Pharmacology and Therapeutics 26(1):S«-62 Kafetzis. D.H. Siafas, C.It. Georgakoponlos , P. i. Papadatos, C.J. 1981 let a ?aediatrica Scanainavlca 70:295-288 (Itlt Fast) ------- 5-TW«-l-«MUCTClo(«.2.ff\|oct-2-«.e-2-c«rlx>rrlle acid. 3-fhTaro7»etBrl»-8-o»-7-(2-f2-tBleByl\|aceta.ido) - acetate fester) 18 CI\| S-TBia-1-«afeicrclo <«. 2.0) oct-2-«'Be-2-earlx«\|rlic acid, 3-«(ac«tjlor)Beth7l\|-e-o»-7-((2-tBieBTlacetTl)aBi»o>-, (8S-tran9)- (9 CI) 1S3-41-7 C«-H1«-»2-0«-S2 11 "«•" TISSOB 5220 . . . _ SKPOSOBS BOVte In1«ctiatt 1H1TTICIL BITSOB licrobiological ITTBSIH or cists 11IGI 0.0-0.16 iig/Bl BS1I Bot giren GZIZBaL HFOSB1TIOI 2 an! 6 he after 1 9. Initial aeasureeent , 0. 27 uq/al at 0.* he ?a>ge of Mi us HCOUS ; BIOO9 SZB1IR: HILK: IITIBIOTICS; DBDGS; IKCTktlOI SEfEHISCE Fa fell Is, D.I. Siafas. C.K. CotqakopoaloE. P.I. ?apadatos, C.J. 1981 Icta Paediatrica SciBlinaTica 70:285-288 S-»i»-1-axaUcTCl»<».J.O)oet-J-«fte-2-carb ------- 5-Ihi.-1-.»Ucyqlo«,.2.0>oct-2-e.e-2-carb<»nic.cid. 7- «0»25-«1-3 CSO-B21-»"MJe-S2 eg 51. «o 1- (c.rto.T«thTl,-1-H-tetr«.l-5-rl)thic, .ethTl)-8-oro-. <68-tra«s>- TISSUE 5225 Blood, Tlasia _ EIPOSOEE none Inflection IfalTTICU HETHOD •OBBEB OF C1SES _ Hiss ~ 210-8 09/1! lot given "GE1IML IIFOMWIO* C.S an« 12.5 hr after 32.3 ig/kg IT Istiiated frci graph Eata also foi logs, rabbits. 1ITT"IOTIC5: B1O09 PlASIiJ CCBP18MITE mi.O»TIO»S: IBTaBOlISB; COGS EEFEBEFCE Siyth, S.D. Rottendorf, G.H. 1980 Toiicoloay and Applied Phariacology 53:179-195 •i-t.i.-1-.x.tlcyclo (•>. 2.0) oct-2-e,e-2-c.rbo«Tlic .cid. 7- ( SC370-12-2 C16-H1T-I3-CE-S Hi 3«3.2 » -3-ietnTl-8-«o-. (6K- C6alpha.7bet» () ) ) - TISSUE 5226 flood. serai 522T Blool. serai 5228 Blood, serai 5229 Bilk 5230 Urine EIPOSDEI ROD1B Tngestion Ingestion Ingest ion Ingest Ian Ingestion lillTTICil HETHOD •icrobiological lierob iological Dicrobiological Hierobiological Hierob iological ID8EIB OF CiSSS 13 20 6 6 13 . U»GB a) 8.981-0.298 ag/il b) t7.841-C.619 ag/il a) 0.3-33.4 ig/1 b) 12.0-56.5 ig/1 c) 0.1-3».8 ig/1 11.6-21.6 ag/il 0.10-1.6 ag/il a) lot given b) lot given 1 sii» a) lot given bt Hot given a) 5.92 ig/1 b) 27.38 ig/1 c) 10.8* ig/1 - fot given dot given a) 89.92* of dose (221.8 ig) b) 86.3^ of dose («31.7 ig) VISE) a) leans, 1.5 and 7 hr after 250 ig. Initial value, 3.282 ag/»l at 0.5 hr b> Beans, 1.5 and 7 hr after ?00 «g. Initial value, 6.369 og/il at 0.5 hr. Health T 20-29 yr olds, «t 62-85 kg, fasted before and daring stady. TSOGS; UTIBIOTICS: BIOOD SIFU1; •cons: iTkiu nsmE a) 0.5 hr after 1 g t) 2 hr after 1 g c) 12 hr aft« 1 g feaV nithin 2 hr in 70^ of patients. 26-77 yr olds, »t 43.8-130.2 kg, fasted overnight- hr after dose. C»BGS: USTIBIOTICS; 1301TS; UHISE; UCOD PLtSill 1 and 3 nr after 1 g lange of leans icni'S; B100D SEB1J9; SItK: 1ITIEIOIICS; DE06S; tlCT»TIO» 1 and 6 after 1 g. Final •easnreient, 1.16 ug/il at 9 hr Cange of leans t CULTS; BIOOE SEBOB: SILK; urtisroTicsj DRBGS: HCTITIOI a) 259-ig icse t) 500-ig dose 0-2« hr excretions Bealthy 20-29 yr olds, «t 62-85 kg, fasted before and luring study. ttUGS; »«TTBIOTICS: BLOOD S5B11: SEtltTS: ITalt; UBISB Prenna, R. Eipl, S. 1980 Cieaotherapy 26:98-102 Catter, P..E. Blair, .D. Kelly, B.B. 1979 Clinical Phanacology an! 'herapentics 25(5 pt 11:511-521 F.afetzis, O.A. Siafas, C.a. Georga^opoulos, P.i. Papadatos, C.J. 1981 »cta Paediatrica Scandinavica 70:285-283 Fafetzis, D.t. Siafas, C.a. Georgakopoalos, P. a. Papadatos, C.J. 1981 acta Paediatrica scandlnavica 70:285-288 Prenna, B. Fipa, S. 1980 Cheiotherapy 16:98-102 ------- S-Thia-1-atabiCTClo («. 2.0) oct-2 5C370-12-2 C16-B17-I3-CS-S gi 363.«2 -•w-2-c.rbo.rlic add. 7-{(ami»c(H,raEO«rpl«arl)ac«trl>a.i.o\|-3-.eT:l,yl-8-oxo-. {6«-<«.lP»».7bet.OI«)»- (COITIMED) TISSUE S231 Brine Bitosvis BOOII Insertion illlCTICaL RVTHOD _ licrobioloq-ieal mm OF CUSS 19 B11CJ ' 10.6-105.81 of dose Bill 68.3* * or - 26. 8* of dos« 0-«8 hr cuanlatlre excretions after 1 9 2S-77 YT «"«. «» »3.8-130.2 I significantly different. 1 1 Healthy cancasian 19-28 yr olds. »o 1 1 Etrennoas exercise. 1 • 1 1 CSHGS' 1ITIBTOTICS; aQDLTS; SEX: 1 1 BIOCO SEBOS; COBPa»»TITB EVMDWIOHS; 1 1 nine J i _ ' a) 88< of dose (»18 I a) Bales, ^•JJJ^J'ljJj",, J Erannick, llj! bl 73% of dose (37 • \| c) "ales, ej°^14 \ seis"E!s'1' I?' 80 of dose (380 ! J«-S"cZi«Utiv«.xcr«tlOBB j 18 (2)": 215-220 flNo of dose (332.5 ' Bealthv Caucasian 19-2S rr olds. Ho 1 lqt \| Etrennoas eiercise. 1 i 1 1 t'BBS: HtlBIOTleS; JBB1TSJ SSI; 1 1 noco ««u«; eovsnvnn EV»to»Tio»s; i I «M« J 1 1 .—•-—. — ' —II 1 — — ... Ln ------- -e-«o-. ,6B-(6alpha.7beta (.)!)- Cl8-B18-»«-OS-S2 11 "62. 5» IISSBI 523« Blood. plasna 5235 Brine Birosnts BOOT i Injection Injection AlALTTICAl HETBCO BPLC BPLC BOHBEB OF casss 12 at 1 b) 1 5-,.l.-l-.t.blcyclo(..2.0,oct-2^..-2-c.rbo«,lic acid. 7-t2-,.l ilB6S a) 70-126 ug/«l b> 46-80 ng/1 c) 21-37 agynl d) lot given e) lot given a) 600-100 »g/»l b) 350-100 ag/nl a) Bot given b) Bot given c) Bot given d) 81.68 » or - 1«.5» ag/nl e) 3. S3 or - 1.2» ag/nl a) Bot given b) Bot given a) After 10 lin, daring dialysis, 6 catlents ) After 30 ain. daring dialysis. 6 catlents c) After ».5 hr of dialysis, 6 patients d) 28 hr aean, interdialyeis, 3 patients «) 28 hr neat, 6 controls tese, 15 ng/kg. 52-52 yr olds, «t 5»-68 kg. »ith chronic renal failure, on heaodialTsis. Healthy controls. IBU6S: ANTIBIOTICS; BIOOD P1AS1J: tlSBASKS; 9HIBE: CORPABATITI a) 22 yr old »lth rlne ontpat of 600 •I/day, 2-hr and 12-2» hr eicretlons after 15 ag/kg t) 52 yr old »lth nrlne ontpot of <100 nl/day, »-hr aad 15-20 ir eicretlons after 15 ng/Xg f.3.6 and 68.2 kg patients, lith chronic renal failure. ElOeS; AWIBIOTICS; BLOOD ?LASHA: tTSEASK; OSIBS; CO«PASATIT1 IVILOATIOBS: ADULTS 1 — • — — BEFEBEBCE Ganbertoglio, J. 6. Aziz, B.S. lin. 2.1. Graasz, B. Baughton, J.L. Eenet, L.Z. 1979 Clinical Pharaacology and Therapentics 26(5):592-599 GaaDertoglio, J.S. Aziz, B.S. lin, E.T. Grausz, E< Paaghton, 'J.L. Benet, I.Z- 1979 Clinical PharnacologT and Therapeutics 26 (5) : 592-599 onbenylacetyll aninol — 3— nethyl— 8— ozo. (6B— (6alpha. 7beta(R)))— (' C!} C16-B17-I3-C«-S II 3»7.« HSSHB 5236 Blood, a«rna . S237 Bilk EtfOSVn ROOTB Ingestlon Ingestlon -- 1I11TTIC11 HITIOD licrobloloqical Bicroblologieal BOBBH OF ClSIS S « OICI . 22.9-13.6 uq/al 0.20-0.50 uq/il 8EiI lot given Wot given GtlEBaL IIFOaBaTIO* 1 a«d t hr after 1 g. Final aeaanranent, 2.7 ng/al at 3 hr ------- z) az«pi..-s-e.rbo«.ta. C1S-I12-V2-0 •t 23.2«. IF 204-20C C 1ISSVI S23t Blood 523 Biooa. tiasi* S2»0 float. Plan* Jlool. smi crnsna MOB — lB,qej«tioB -' 1IU.TTICIL ratsas •s cc OC/BS •onn or cisss 2 S 10 6 HfGI •1 lot giTm b) lot give* c) lot given 41 lot given •1 lot glvci f) lot gives 9) lot given h) lot given 1) lot gives J) lot give* - 7.80-3.10 ag/Bl •) ».6-7.7 Bg/1 b) 0.31-1.01 ig/l a) 1.55-3. 12 ng/il b) 1.79-2. tO ng/Bl C) 1.33-2.10 «g/Bl BMI 1 GSIEMl Iiro«l»TIO» _ 1— b! »'s5 ".i?^1 ! I.1 c«"«««Fl»«. "tier, 2nd d.r « 5'S !»l^t * CjcbawMFl... child, 2nd d.T 2 7 . HJ ' c) 1(>."-ePoT c«rba.»T«pin« « i'J °KJ ' «««t«l»Ht«). .otker. 2nd da; S S:i ::i;i \| !ia1S;;''ei>OIT «»••««". =«id. !! o'2 !^J^J ' t1 C«rt«»»«Pl««. "ether. 3rd «.T l! !; n ( , ' f\| c«>»«««Fi»«. cllld. 3rd day i! "sv.:^1 i Ua's.;1-'0" «•""-«. •«-. 1 b) 10,11-cpory carbaHzpiB«. child, 1 3id day 1 t\| Catbaiazcplae. mother. 30th day 1 jl CacbaaaicFlne. child, 30th day 1 »»liea for «tt«r delirerT- 1 Patient took 8 «flA« cacbauzepine 1 aid « «q/ ------- «B-eib«M Cb.fl «xepi»e-S-c«rtox»mia« 115-B12-I2-0 CI 23C.26. » 204-206 C 1ISSIS 5242 lllk 5243 5244 ori»e BiroSOBE BOflTB Ingest ion - IBILTTICU. BETBCD OC CC BOBBEE OF C1SBS 1 7 5 IIKS a) lot gi»«n b) lot given c) (ot given d) lot given e) lot given t) lot given 1.17-1.7* as/1 a) 0.35-0.87* of dose b) 1.02-1.41* of dose c) 32.7-60.6* of dose d) 5. 17-8. SOT of dose BEIB at 7.5 a Ml/1 b) 2.6 u nol/1 e) 5.5 n aol/1 d) 1.8 u aol/1 e) 7.5 a aol/1 f) 4. 4 n sol/1 1.37 ag/1 " a) 0.52* of dose b) 1.14* of dose c) 49.9* of dose d\| 6.80* of dose . — a] carbaiazecine, 2nd day t\| 10,11-epoiy carbanazepine (tetabolite), 2nd day c) Carbasazecine, 3rd day d) 10,11-epoiy carbaaazepine, 3rd day e) carbatazeplne, 30th day f) 10,11-epory carbanazepine, 30th day Patient took 8 ng/k? carbanazepine and 6 ig/kg dlphenylhydantion daily durinq gestation and lactation. DROSS; BIOOD; lactmos; BEWSOBI: IIT1BOIITES: BIIK U— — — liter daily doses of 5.3-21.0 ng/kg. Saliva and plasaa levels r-0.991, ratio-0.26 + or - 0.01. 17-63 yr olds on lonq-tern treatment for epilepsy. IS06S; slTICOBVUlSMTS; BIOOD PUSH: SS1TTR CO^Plfi4'I^S BYUi U1HO1VS » ------- SO-7-S C18-B22-I2 Bl 2<«.37. B 172-17* C at 0.02 aa Ba TISSUE 52« Blood, plasaa 1 1 1 1 \| 1 neoson BOOTS Ingest Ion iiunicit HETBOD Sit 1 1 I 1 1 1 1 1 1 1. IOHBSS OF CIStS al 1 14 1 c\| 1 1 1 1 t max a) 43-30 ng/nl b) 18-1.9 aij/al c) 7-0.4 ng/nl 1 1 BB1I a) lot given b) lot given c) lot given 1 1 1 1 1 1 1 i GEVEBaL IITOBBaTIOB 1 a) 7.5 and 72 hr, patient »lth lo« Beta phase values b) 7.5 and 72 hr, patient «lth »edinn Eeta phase values e» 7.5 and »8 hr. patieat «ith hiqh Beta phase values liter 50 nq as the hydrochloride. ictinated £ron qraphs • leta phase, aonoexponential tecninai decline tegtessed patients, in qood rhyaical health, fasted overnight and » hr after I., dcse. MOSS- 0»lJG T.BBBUI: IBMBEWBSSXTE a«EITS; S100D Pl»S«l; SBTUOLITES BEVEBERCE Brnnsvick, D.J. Aasterdaa. J.D. nendels, J. Stern, S.I. 1979 Clinical Pharaacology and Therapeutics 25(5 pt 1): €05-610 i Jibe Ib tlazepine-5-propananine. 10,1vaihl4ro-»-nethvl-, nononT«irocBi.oiitt« »> v-^i ««-28-S C18-B22-I2.C1-1 C« 302.88, » 214-218 C 1 iissni 52»7 Blood. plaaia 1 1 1 1 l_ 1 Blood. plaaa _— "UBCII 1 "" ' bliinai. iiruan.--. 1W \| BETBCD » O» C»SBS _ _ 9 m) 12_30 mfl/ml ., 21.,, »,/.! a> 3 hr after M> aq < Injection w- 1^. fo-28 no/l hi 19. n ng/ai =1 uc a lose Healthy 20-59 yr olds. London. 1 tnq la * 1 1 IB9SS; B100D Pt»S1l»: IDtJWS; 1 \| CCS91BMIVJ »f»m»TIOIS: 01ITED 1 1 1 micnoi 1 .1 _ 1 Inqestion 1 5C 1 _ — \| J b) lot given 1 b) 71 « or - 37 ng/al 1 « ^j^atter1?1^ 1 ! 1 bedtlse. I \| 'aaretie boys, sean I Increase in plasaa I staadln?. Sise in I Eiy aoath. i caainc » 7* no/day at aqe 9.8 » or - norepinephrine on sopine pulse rate 1 Dnes; canwEi: SLOOB ?BESSOSB; I neon ptissi: DFOS i TBtBlPI \| BirESERCE 1 5 1 Ehsannllah, F..S.3- I Qhose, K. 1 Flrby. B.J. 1 Turner, ?. 1 altts. D. 1 1977 1 PsychopharaacoloqT 1 52:73-77 1 1 lake, C.5. 1 l!ikelsec. S.J. 1 Papoport, J.I. 1 Fopin, I.J. 1 1979 1 Clinical Pharaacoloqy 1 an9 Therapeutics 1 2«C5):««7-€53 . 1 ' ' ! — — (MIT B»B« .O vO VO ------- C18-H22-B2.C1-B II 392.18, IP 21«-21B C (CORIIVED) 15SO-1580 »g/«l 1570 ng/«l GE1EB1L Ccaks. Data for nlied desipriine-BCl and iilprailne-BCl overdose also aTallable. Overdose patients, ages 17 an 22 Y- OJS Interval of 190 nsec or greater on ro«tin« ECS, aaa o«o or lore of tb« follovlng atnornal deef tendon reflexes, ventricular rate of 120 beats/Bin or ------- CD CW-B2«-«2 1ISSOI 5252 Slood, flasma I 1 1 1 1 1 I 5253 I Hood, 1 I 1 1 I 1 1 1 I Bitoson -ow« tinmen BRBOB Ingestion OC 1 1 • 1 1 1 1 I 1 \| Ingest ion 1 Bit 1 1 1 IOSBM or etas 1 i i i . __.-_ , .-„ miiti zmsuTKH 28 « or - 21 ng/ml It » »S after 2 «k on 7S mo/day at bedtime. lincetic boys, mean aqe 9.8 » or - 1.9 yr. try month. Increases In sapine and 1 standing p«lse rate, diastollc blood 1 pressure, and plasma norepinephrine. 1 cizziness on standing, seduced 1 ecvresis. \| MUSS; C-119S-B: B100B PBESSOSE; 1 U.COD eilSUl: B806 TBSBa»I I 1 — ~ 1 . t m\ mi* MI won 1 al -t alp rM -.!»€• Bio-tponfintlal acclln \| a) 20-0.8 ng/-l «1 »* 9£« t> Deseethylinipramlne (aetabolite) . \| bl 13-* ng/ml BI sot given i goBOeIpl>seiltial decline 1 \| 7.S an* 90 hr after single dcse of i 1 l mq as th« hydrochlorile 1 \| titlmatea from graph. I ncalthy -tolnnteer fasted o-ernight 1 and » hr after US. dose. I '. nsoss: BBHG IBBHUT; MTIBBPBESHTB t J leiins: sices ntsats B-TtBOLiiss ~j EEFESUCI 1 1 ____ 1 I Lake, C.B. 1 MlUelsen. l.J. I Sapoport, J.I. I Fopin, I.J. \| 1979 1 Clinical Pharmacology 1 and Therapeutics I 26(5)s«»7-653 1 1 1 • 1 , e 1 Brnnsvick. D.J. I tisterdai. J-0. I Rendels. J. 0 \| Stern, S.L. \| 1979 I clinical Pharmacology and Therapeutics 25(5 pt 1):605-610 Ln O 113-52-0 C«-B2m-«2.Cl-H ^ " l~ I Hood, tlasma 1 1 iXIOSVR. S001I ,.,-sUo, iinmcu. HIIHOD ec/sr 1 1 i or c-sss 1 BUGS 1 1 Bot applicable 1 1 1950 -a/ml 1 leak. Bata for mixed i.ipraalne-HCl 1950 »g/ml i ^ aesipramlne-HCl orerdose also I available. \| Cterdose patient, age 29 yr. 1 CIS of 100 msec or greater en routine \| ICS. an! one or nore of the following 1 atnormal de«p tendon refleies. 1 ventricular rate of 120 beats/iin or \| greater, right handle branch block, \| atrial and ventricnlar premature I contractions. Innctional and I Idioventricnlar arrhythmias. i unconsciousness, respiratory support I necessary, grand aal seizures, ana 1 death. 1 CB«GS; M-I3M1BSS1TB ICMTS: 3MO9 1 imsnt: trvc, IBOSE; ntssoosi i — Biggs, J.I. Spiker. D.G. Petit. 3.S. Zleqler. 7.B. 19T7 Journal of the amerlcan Fedical Issociatloa 238(2) : 135- 138 1 1 1 ------- SB-mbe«o{a.« ciclok«pt«.«-«.lt.<5,.J»..a)-propll«.i»«. 1. 1-Propaaalae, Vt19,11-dibydro-5H-dib«««o(a.a)CTclob«pt«B-5-Tli dene) -»-aetByl- C» C 19-H21-1 11 263.37. IP 213-215 C tXSSBE S255 Blood, plasaa 5256 Blood, plasaa _ 5257 Blood, seen • BIKS9BE BOOTS iBoestioa IngestiOB iBjectioB lagestioa uitmcn HETHOD SC " Badioaetry GC ... itnBEB or cms 12 c 9 I1IGI — a) 31-38 aa/Bl b) 52-38 ag/al a) 670-1500 br a«/l b) 1430-3030 br ug/1 50-B50 ag/al a) lot applicable b) lot applicable a) lot gi»en b) lot given lot gives -- GiilBii iKosamoB a) 0 and 2« br after 6 daj regleeB of 3 1 25 eg/da? as tablets. 36 ng/«l at 7 hr tl 7 and 2» br alter S Say re«iBen of 7« BO/Say slB^le tablet. laitial Btasnceaent, »1 »<1/»1 at 0 hr. B«altliT 18-60 Jl Ol4s «I1T!D KIIGDCE: BLOOD; BtOOD Pl»S«»; icons: niHtons STSIOT DISMSSS; DSDS THIg»PT; COMlBiTITE gT»lOWIO»S; IITIDBPMSSITE »SS»TS a) Jfter SO j iac-labellea dose. t) after 0 Bq 1«c-labelled dose, IT Irea nnder the carre data BtalthT. 21-28 ft olds OB »o otber i«dicatioi>. SCM sedative effect in Boat. HFBSS: Di»a»fK: BLOOD FllSHi; COHP»B»TITI IfllHTIOSSj IDOLTS — — — ' ' —————— —^ 12 be after last dose of 50 j 3x/«ay fcr 2 ». Talnea estiaatefl froa qtapb. Jcspitalired patients. D10SS; BIISOSBBIIT BITHODS; CE»B»BK; IIOOD SBHOS: »»TIDJPFBSSITI »SSITIS tEKSEHCI Hacker, H.B. staaffer, S.c. Clayton, F.G. lakra, B.B.S. Gaind, B.B. 1975 Journal ot Clinical Pbartacologi 15:168-172 — — Graa, L.F. OTero, K.T- 1975 Clinical Fbaraacology and Tberapeatics 18(31:305-314 Jorgensea &• 1975 Acta Pbaraacoloqica et Toricologica 36:79-90 o ro ^^^^ •l°277?39, at Hydrocbloride 196-H7 C 1ISSOB 52S8 Blood. plasBa EHOS0B3 SOOTB IngestiOB . IHLTTIClt RBTBOD '" sc/as OF CiSSS 12 SatSE a) 29-151 ng/al b) 5-179 ag/al c) 5-21 ag/al d) 53-130 ag/al e) 26-112 og/al f) 12-258 Bg/Bl (BUT flBll a) 81 * or - «o ng/al b) 71 + or - 57 ag/al c) 12 « or - 5 ng/al 4) 91 « or - 30 ng/al e) 82 + or - 27 ng/al f) 176 » oc - 6» nq/«l ?15B) GIBZBll IIPOBHKIOS laitriptTliBe nortriptiliii* 10-Hy^royaaitriptyliBe 10-lTlroxyaaitriptTlihe conlogate 10-Hyiroiynortriptyline ., 10-MTdro»yBortriptyline connate HlaiaaB steady state Tallies on SO ag aaitriptyline, 3r/day. 61. «-10». 1 kg aen. EBBGS; SBMBCIITES; WlStJBSB'BT BJ18OBS! BiCCD PL»SH»: WTIDIPBISSItB Garland, t.». Boccino, K.B. Bin, B.9. Capano, J. Fann, ».t. 1979 Clinical Phar»acology and Tberapeatics 25(6):8«»-856 ------- •O-M-6 it rn.39, n «TdrocM.oria« »6-m c 1ISSVI 5259 Blood, plaaaa 1 I 520 I Blood. I plaaaa 1 1 1 5261 Blood, 1 1 1 i inoson BOOTS i«M--«i i« SBTBOD Of C Ingestioi 6C 12 1 __ _____ I Xagestloa 1 8C/BS 20 i i i ! i ( 1 ! lagestioa 1 8C »{ I 1 D> 1 1 1 1 1 1 1 I 1 1 I BJS Bines ISIS a) (0-50 ng/al b) 90-5 ng/al 1 { 1 ... , 1 a) 25.6-58.6 ng/al 1 1 b) 11.a-27.« ng/al \| c) 29-151 ag/al \| d) 5-179 ng/al ' 1 1 1 1 1 1 1 2 a) »7.5-7 ag/al 9 b) 20-20 aq/al 1 1 a) lot applicable a) » a»a 2» hr after 6 aaT reglaen of b) Bot applicable ..LareaSn^SO^/.l'^1'"^^ 6 ana 2» hr after 6 daY regiaen of 75 ag/day single tablet. Initial xasaremnt, 50 ng/al at 0 hr. Healthy 18-60 IT olds i 1 flllTIB KlUStOS; BLOOI; B100D fllSKl; 1 HUMS; DBtIG TEEBWT; COBPiBATIT! M»1UWIOIIS; HTID»BSSSIT! 1GISIS a) 39.» ng/al •) Peaks about » hr after 75 ag as at 71 t « - 57 ag/S 75 •^•'tphule^for.' Irt'SlT" i dose of 50 aq 35t/day for aoath. 12 I : ------- 8 3 SM-M-8 CJO-823-B.C1-B tl 313.85. if 19S-M7 C TISSUE 52(2 Hood. Tlasea EXPOSmi BOOTS _ Ingest ion BITBOD oc/Tir BUBBEB or c»SBS 7 BHGS 11M-2190 ng/nl mi 1639. »3 ag/nl eilEBll IIFORlATIOl lean peaks. Data for slxed anitriptyline-SCl ana doxepin-8Cl overdose alsc available. Overdose patients ages 19-»5 yr. OSS of 100 ssec or greater en routine ICG. and one or sore of the follooing abnornal deep tendon reflexes, ventricular rate of 120 beats/sin or gieater. right bundle branch block, atrial and ventricular prenatare contractions, luactional and idioventricular arrhythnlas. unconsciousness, respiratory support necessary, grand nal seizures, and death. BUSS; WtltfPBESSITt IGEIIS: BLOOD EIASm; BS06 aBOSEj 1ISSOOSI SIFEBEBCE Biggs. J.t. splker, B.G. Petit, J.I. fleqler, T.B. UTT Journal of the aaerlcan Eeaical Association 238f2) s 135-138 I-ol. 3-(1,2-di«thylheptyl)-7,8.9,10-tetrahidro- 6,«,9-trl«ithyl- C25-B38-02 f 370.63 ussas 52«3 SlOOd. Flassa ElfOSIB! BOBtl injection UllTTICiL BBTBOD tic Sadlonetry BDK8SH or cists 3 BIKE " a) 1800-30 dpa/al b) 100-11 Ip«/«l (Itll IISaB a) lot applicable b) lot applicable — GUISll IfTOEUTIOI a) total radioactivity 0 and 72 hr after dose tj Unaltered drug 0 and »8 hr after lose range of leans after 200 nq 1»C-latelled drag. It. Estimated fro. graph. lornal 21-23 yr °w casnal larihaana stokers, to habitaal drag usage. TachycarSia starting ID ^-20 aln and lasting »-« hr after dose. Hypotension peaking at 1 hr, listing > 12 hr. Dininess on standing. Dry •ooth and dcovslaess after 2 hr. tnthoria in 1 patient. CBBGS; S5TJ9CIISS: ILOOD PL1SBI; (rai»B: Fscis; 5EFESSKCI U1 O lenterger, L. HcHahOD, B. Archer, B. Ratsaaoto, !C. Bowe, F. 197 Clinical Pharnacology and Therapeutics ------- -7.8.9.10-t.tr.n,d,o- 6.6.,-trl.t.yl- Bl 370.63 JISSBB •rlne cirosoii BOOTS - Injection iliimcit BRBCD Badionetry iolSS OF CISSS 3 (COIT iiiei a) 2-3* of dose b) 5-8* of dose c\| -16 of dose [BUBO) nai — a) Bet given b) lot given c) (ot given " SBIJWL IBFOmTIOB ' a) » hr b) 2* hr c) 7 days Cnnulatiye excretions as S of total ""J»;t}»ity. after 200 ng IT HC-laeelled drog. Ha-\|or excretion •as in feees (53-61* in 7 days) . Bornal 21-23 yr old casual narihuana nokers. 10 hahitnal drtig Bsage. Tachycardia starting in 5-20 ni. and lasting «-6 hr after dose. Sypotension peaking at 1 hr. lasting L . ""inass on standing. Dry south and drevsiness after 2 hr. loihoria in 1 patient. BBMGSs IBTIBCIISB: B100B PUSHi; BSFZBEBCZ " lenberger, I. HcRahon, a. Ircher, B. Hatsnnoto. K. Eo»e. H. 197» clinical ?harnacology and 7herapeotics 15 (») -360-386 C«-H11-«5-o3 II 225.2» 1ISS1S 52,. ¥lth aJvanced cancer WSS! CIMCTTOa.Wr; BLOOD rUSBk; jsKSLiSr-siiois,?' "WIMW! a) 0.5 «g/)tq b) 1.0 ng/, c) 2." ng/Xg J) 5.0 ng/q Cviulative 72 hr excretion of fluchan^ea drag after 1 hr IT »9-82 yr oia,. ,t 41-117 q. ,lth a<]>anc->l caacer MUSS; CRVBOTHnin; BIOOB H»S1- ffisstjur.ga-jss?""""" ———_____ de nlranda, p. •hitley. S.J. Blon. H.E. Keeney, B.I. Barton, ». Cocchetto. o.f. Good, s. Penstreet, 15. p. HT Mrk, l.s. Page. s.\, Hlion, 5.B. 1979 Clinical Pharnacology and Therapeutics 26(6):718-728 de Miranda, p. mtlev. S.J. Elan. n.t. reeney, R.». Barton. 1. Cocchetto. O.F. eool. s. Reistreet, s.p. in rirt, I.B. Page, D.A. Zlion, G.B. 197« Clinical Pharnacology »»d Therapeutics 26(5) ; 7 (8-723 - O Ui ------- 7B-»uro(3,2-o» \|1)beMopTr»n-7-o»e. f-»etlor»- 218-61-7 C12-B8-0* El 2U.1I. ft 18 C USSUE S2«7 Blood, plasia Blood, tlPOSOBE BODTE iBgestiot iBitnxcai BRBOD 00 BC 8C-EC _____ _ — — — BVB8SB or CUBS 5 5 a) 6-2t* Bg/sl b) 180-590 Bg/sl - J50-700 na/Bl BMB a) 177 ag/Bl b) 32« no/nl lot given a) Peaks, fasting. Peak tines V2.5 hr t) Peaks, after intake of standard breakfast. Peak tines 1-2.5 kr liter 40 aq as 10 »q tablets. Peaks in a) and b) differed significantly. tealthy sales vith noraal renal and hepatic function, fasting 10 kr before dose and on no other drags. OSOGS; SKIB DISEASES; SWSDEB; D1IBITI01ET BiPIltlOB; JOODS; BWOB PIISHI; COIPIBltlTB SV11U1TIOBS Bang* of peaks 0.5-2 hr after about 0.6 so/kg as fast-release tablets. Ill had < 30 na/Bl bT 5 hr. SllghtlT pigvented, adults vith fcorlasis. Irrthen* in response to ov exposure. leniitivitT related to sens levels. r«0.78, p<0.001. tinos; a SO^EIEBT H7TBQPS; SItlTITIS; iBTTDEPFSSSIT! aGMTS; PICOD M.ISSI; FIEBItS; BBT»BOt«SS . Jlndal, S.P. Vestergaard, P. 1980 Journal of Pharsaceutical sciences ------- J.10-Secoc»ol«st»-5.7,10(19)-ttl»»«-3b«ta.2S-aiol (g CI) «.tO-S«cochel«st«-S,7,10\|W)-trie»«-3.2S-diol. (3beta,5Z,7!)- <9 CI) H3S6-17-3 C27-HM-02 BE •oo.fi'; IISSOI 5270 Blood 1 1 1 5271 I Blood, plas» titosns soots aiunicu IQBBSI »»•« »111 RETROD OF CaSIS b) lot give! b) 32ls nnol/1 c) lot giT« <=) 28.0 MOl/1 4) lot given d) 20.0 n.ol/1 f) lot given f) 29.3 naol/1 I I 1 a) »t delivery. fro« nothers on vitaiin supplement b) Fron control lothets. at aelirery c) Fro« cora. «ith vitania s«pple»ent a) Fron cora controls e) Fro* lnfants-»ith vitanio : ------- 509 5087?-IQ1 REPORT DOCUMENTATION i... REPORT NO. EPA 560/5-81-008 A and B 4. Till* and Subtitle Chemicals Identified in Human Biological Media, A Data Base, Third Annual Report, October 1981 2' EIS-163/V3/ _li _and_P2 Accession No. \| 5. Report Oat* 7. Author(i) M. Virginia Cone. Margaret F. Baldauf, and Fay M. Martin •. Performing Organization Name end Address Chemical Effects Information Center Information Center Complex/Information Division Oak Ridge National Laboratory Oak Ridge, Tennessee 37830 12. Sponsoring Organization Nam* and Address U.S. Environmental Protection Agency Office of Toxic Substances Exposure Evaluation Division (TS-798) Washington. D.C. 20460 IS. Supplementary Notes 8. Performing Organization Rept. No. 10. Proiect/Task/Work Unit No. 11. Contract(C) or Grant(G) No. (O EPA IAG No. 78-D-X383 (C) 13. Type of Report & Period Covered Annual Report 9/80-9/81 14. 1«- Abstract (Limit: 200 words) A comprehensive data base of chemicals identified in human biological media (tissues and body fluids) has been established under the direction of the Environmental Protection Agency's Office of Toxic Substances Exposure Evaluation Division. This centralized resource of body-burden information was inspired by the concern of government scientists over continuing reports of toxic chemicals in human tissues and body fluids. Body burden is a reflection of exposures to food, air, and water contaminants, ae well as Pharmaceuticals. The systematic acquisition of body-burden data will facil- itate a more relevant assessment of human exposure to toxic chemicals and xenobiotics than was previously possible using environmental contamination levels. Data were obtained primarily from the open literature through manual searches of selected journals. Retrospective searching to 1974 is complete and has yielded over 3800 pertinent documents of which approximately 1600 have been entered into the data base as of this report. These sources identify over 800 chemicals which have been found in human biological media. 17. Document Analyst! a. Descriptors Body burden Human tissues/body fluids Residues b. Identlflers/Open-Ended Termi e. COSATI Field/Group 18. Availability Statement RELEASE TO PUBLIC 19. Security Class (This Report) UNCLASSIFIED 20. Security Clan (This Page) UNCLASSIFIED 21. No. of Page* 944 22. Price (S*ANSI-Z3».18) See Instruction! on Reverse OPTIONAL FORM 272 (4-7 (Formerly NTiS-35) n«nrtmnt o Commerce ------- 511 EPA 560/5-81-008B ORNL/EIS-163/V3-P2 INTERNAL DISTRIBUTION 1. S. I. Auerbach 2. M. F. Baldauf 3. M. V. Cone 4. J. T. Ensminger 5. W. Fulkerson 6. H. B. Gerstner 7. F. M. Martin 8. C. R. Richmond 9. G. D. Robbins 10. Biology Library 11-12. Central Research Library 13. Document Reference Section 14. ICC Publications Office, 2001 15-24. ICC Resource Center, 2001 25-26. Laboratory Records 27. Laboratory Records, RC 28. ORNL Patent Office EXTERNAL DISTRIBUTION 29. Philip L. Johnson, Executive Director, Oak Ridge Associated Universities, P.O. Box 117, Oak Ridge, Tennessee 37830. 30. Office of Assistant Manager, Energy Research and Development, Department of Energy, Oak Ridge Operations Office, Oak Ridge, Tennessee. 31-57. Technical Information Center, Department of Energy, Oak Ridge, Tennessee 37830. oU.S. GOVERNMENT PRINTING OFFICE: 1981-546-067/347 -------



Co
Chemicals Identified In
Human Biological Media,
A Data Base

Third Annual Report
October 1981
                         Volume III Part 2

-------
                                         EPA 560/5-81-008A
                                         ORNL/EIS-163/V3-P2
CHEMICALS IDENTIFIED IN HUMAN BIOLOGICAL MEDIA,
                  A DATA BASE
       Third Annual Report,  October 1981
              Volume III,  Part 2
               Records 3501-5271
                  Compiled by

    M.  Virginia Cone,  Margaret F.  Baldauf,
               and Fay M.  Martin

      Chemical Effects Information Center
          Information Center Complex
             Information Division
         OAK RIDGE NATIONAL LABORATORY
          Oak Ridge,  Tennessee 37830
                  operated by
           UNION CARBIDE CORPORATION
                    for the
             DEPARTMENT OF ENERGY
          Contract No. W-7405-eng-26
 This effort was accomplished under the aegis
   of the Interagency Collaborative Group on
 Environmental Carcinogenesis, National Cancer
   Institute, National Institutes of Health,
     Chairperson,  Dr.  Herman F.  Kraybill.
         Date Published — December 1981
         Cindy Stroup,  Project Officer
         Design and Development Branch
         Exposure Evaluation Division
          Office of Toxic Substances
     U.S. Environmental Protection Agency
            Washington, D.C. 20460

-------
                                CONTENTS

 Part 1
   Acknowledgments	   v
   Introduction   	 .   ^
   Users'  Guide   	   3
   Abbreviations  for Analytical Methods   	   7
   References  for Data Base	   9
   References  for Physical and Chemical Data	  51
   Appendix A.  Journals Searched  	  55
   Appendix B.  Chemicals in Data Base (1979-1981) by CAS
     Preferred Names 	  59
   Appendix C.  Chemicals (1981) by CAS Registry Numbers and
     Preferred Names 	  83
   Appendix D.  Cross-Referenced Chemical Lists  	 103
     1.  CAS Preferred Names — Common Names	105
     2.  Common Names — CAS Preferred Names  	 141
  Appendix E.  Tissues and Body Fluids in Data Base
     (1979-1981)	325
   Indices	329
    Author  	
  Corporate Author
  Tissue
  Keyword ............................  367
Directory of Chemicals (1981) ..................  377
  CAS Pref
  Formulas
    CAS Preferred Names ......................  379
                                                                    090
Part 2
  Data Base
    Nondrugs  ...........................    -,
    Drugs .....................  ........  345
                                  iii

-------
NONDRUGS

-------
Icctaldehyde
75-C7-0
CS-M-0
!« M.05. IP -123.5 C, BP 20.8 C
TISSUE



3501
Blood






3502
Blood















3503
Ereath









3584
Ereath











EIEOSOBE BOUT!



Inhalation






Xngestion






































AIALTTICAL
BETHOD


SC






















GC/!!S









CC-IS












IUHEEB
OF CASES









4















8









54 (387
samples)











IAIGE



a] 0.403-0. 593*110 (E-3)
1» 0.545-0.847*110(8-3)






a) 5.015-16.387 ag/«l
b) 9.160-11.050 ug/»l















Hot detected-79. 0 ug/hr









Hot given












HSAI |

1
I
a) 0.494M10(E-3) |
b) 0.6611I10(E-3) |
1

1
I
1



a) 10.41 + or - 3.76
uq/ml
b) 12.88 + or - 3.31















22.7 ug/hr









3.3 ng/1
oeoietric











GUIEiL IIFORBATIOI



a) Mo trickloroe thy lens treatnent
t) 100 ppi trichloroethylene
Banqe and lean foe 6 hr period

20-26 vr old students, wt 62-77 kg.
CE1CRIMTID BTDFOCABBOHS; ALCOHOLIC
EIVMACBS: BIOOD: BLOOD PLASBA;
OSIII: BETABOLITES; BETABOLISB;
AUDITS; SEBSJHT
--- -
a) After 0.5 q/k
-------
  Icetic acia ethyl eater
  H1-78-*
  C(-68-02
  Bl 88. Id, BF -83,6 C,  BP  77.15  C,  T? 100 II 3g at 27.0 C
iissnz
3505
E«ath
3506
Enath
_
ZIEOSOBE goal


minicii
RETROD
SC/BS
SC-SS
irasEts
or c»sss
8
5« (337
saiplas)
f SJfSE
I
lot detected- 1«l»TICH: BETIEOLISB; BII1BOUTES:
( PCPOllTICH ElPOSOSBi JBBlll »IiS
1 _ .
BEFES5SCE
Contla, J.3-.
CaBpr B.J.
telch, E. E.
1»75
irdilTes of
iDnicouectal Bejlth
30 CJ) =290-395
EiotaszjDStl, B. K.
BcaBeao, G. 9.
C'Keill. H.J.
1979
Coacnal of Aaalrtical
Tolicologi 1:225-234
tcttlc acil. allrl *««  (9 CD
Icetic atria. 2-prapeirl est«r  (3  CI)
"1-8T-7
CJ-B8-02
*t IOfl.13. SP 10« C
I 1ISS01
1
3507
treat!











titosats scan













lutmcit
GC--TS












1 imsss
1 Of (USES
5t [387
sai pies)











I IKE
Rot fire*












BEil
0.296 ng/l
Geometric











GEIIB1L 1»F05BJTIO»
naaued at 25 C at 3 7iO ai B?
Jtf . *T occurrence
l<:»er a»J upper one-Sign limits
0,0»3 aid 0.435 nq/1

BeaItkT< T9-35 rr old, coosioHlxr,
•Ttan blacks aid caocasiais.
Chicago. II. Bigiflly contiolled
expcriaentBl condltiois.
tll»9; 1ICOG01S; IILI1IOIS; IDHITS;
CEiCRimirn trosociseois; TOUTIIE
CS01.1IC COBKWDS; BULTB BlZ>BIS:
HBIHTICII-. BETISOHSB: BETIBOUTBS:
ICPOLlTIOfl riPOSOil; tllBiS IEEIS
EEFEE29CE
FTOtOEZfESlli, 3. K.
C'«eill^ B^jJ
1979
Journal at lealrtical
Toiicology 3:225-230








-------
ic«tic acid, butyl ester
1S3-8«-«
C6-B12-02
B« 116.16. BF 126 C. TP IS •• Bq at 25 C
iissns
3503
Heath
3509
Breath


ErPOSBBE FOOT!




IHlTTICAl
flETBOB
GC/BS
GC-BS


JDlEla
OF C1SSS
8
5» (387
Maples)


EMGE
Hot givea-41.0 ag/hc
lot given


BEM | GtlEHL IHT08HTIOS
1
1
9.1 ug/hr (Ccatound related to aoraal
I tetabolisi. So other details given
|C cyoqenic saiplinq technique.
1
inealthr illitairy and civilian-
(eiployees. U.S. tic Force school of
| Aerospace Beaicine, ages 23-47 yr. 3
jsioters.
1
|MSZE«ES; CBIOP.IMTED BTDBOCH.BOHS;
|C FLOS HE OBGHIC COBPOOSDS;
ICH10BOBEHZIIIS; FIOOBISE COHPOIUDS:
IEHI1TH; llCCHOLS; TEIAS; 1DU1TS
1
|
0.200 ng/1 | teasuced at 25 C and 760 la Bq
Seoaetric , I 30. «t occurrence
1 lover aid upper one-Sigaa lliits
1 0,055 and 0.139 nq/1
IBcalthy, 18-35 yr old, nonsaofcinq.
I Chicago, II. Bigidly controlled
I
)EB!»TH: tlCOGOlS; I III SOI S; IDOLTS :
| CItOBI!HTE5 ETDBOC»BBO»S; VOI»TI1E
| CTGIHIC CODECOHDS; RZkLTB SUZiRCS;
II1B1UTICK: SETiEOLISn; HET1E01ITSS:
| FOPHL1TIOII IIPOSOBS! OSB»H 1BE1S
BEFERERCE
Ccn*le. J.P.
Caap, B.J.
Kelch, S.E.
1975
Irchives of
Environaental Health
30(21:290-295
Krotoszynski, B. K.
Craneaa, G. H.
O'Neill, B.J.
1979
Journal of Analytical
Toxicology 3:225-23*


Icetic acid, octyl ester
112-1H-1
C10-B20-02
If 172.27, BE -38.S C, BP 210 C
tissue

3510
Ereath













SIEOSOHE ROUT!
















»»»trric»i
BETHOD
GC-SS














808 EES
OT C1SSS
5» (387
Saaples)













HUGE

Rot given














SEkl | GEH'BAL INFC5SXTTC*
!
0. 168 ng/1 I Xasarei at 25 C and 760 >a Rg
Geometric |«.U occurrence
t lever and upper one-sigaa liiits
|0.0»2 and 0.679 nd/1
1
(Bealthy, 18-35 yr old, nonsmoking.
I urtan blacks and Caucasians.
(Chicago, II. BiqidlT controlled
jeiperiieatal conditions.
(BBS4TH: HCCHOIS; IlimOIS; M91TS:
|CB108I!HTEB FIDBOC1BBOSS; ?Ol»TIL!
ICBGMIC C09PCDHDS: BEAITH BIZSSDS;
| IIHIHTICH; 8ET1EOLIS9; BF.TKOLITE5:
| PCPOL1TIOI EIPOSOBE; D5BAS AFEAS
1
BEFEBERCE I

rrotoszjnski, B. K.
Brtinean, G.B.
O'Seill, H.J.
1979
Journal of Analytical
Toxicology 3:225-23«









-------
    Icetic acid, phenyl- (8 ell
    Eexzeneacetic acid (9 CI)
    103-82-2
    CE-B8-02
    BS  136.1«,  BE 76.7 C, BP 265.5 C,  T? 1 •• Rq at 97.0 C
tISSOE

3511
Breath












EXFOSDBE BOOT!















1S1IITIC11
HETBCD
QC-BS













HOHBEB
OP C1SBS
54 [387
sag pies)












HUGE

Vot given













SE«»

0. 161 ng/1
Geoietric












S!IIE»L MKJSaaTJOH

Eeasnred at 25 C and 760 11 BS 161.2,  HI 276 C, BP 227 C
I1SSBE
3512
Breat











IIFOSD55 ROOTE












HJLItlCH
SETHcn
5C-BS











SOBBFE
or cisEs
5* (387
sanp es)










BIISE
Hot given











K»J
0.115 ng/1











CltlSll IirOBUTIOl
feasared at 25 c and 7CO » Eg
Ic«er and apper one-Sigia Units
0.038 and 0.3«9 og/1
Bealthy, 19-35 yr old, nonsmoking*
nrtao blacks and Caucasians.
Chicago, It. eigidly controlled
cxperinental conditions.
tBIJTB; JICCBOIS; IltlHOIS; «DDLTS;
CBI05IMTED EIDROCIEEOBS ; V011TILE
CFG1M1C COICCDIDS; RI4ITH BiZlBUS;
IIHlItTICN; BEIJtOLISS; HEI1EO11TES;
ICPDLITIOH flPOSDPE; 1BBJLB IBEJS
1 SEFESEHCE
KIoto«,S£Xi, M.
C'Keill^ B. J.
1979
Toxicology 3:225-23»








tcctic acid, propTl ester
1C9-60->
C5-B10-02
II 102.13, HP -92.5 C, BP 101.6 C,  »P 10 In tig  at  23.8  C
1ISSOE
3S1J
Exeath










1
IFOSOE; BOTIIE













SfTBOB |
GC/SS










I
1
OF C1SSS
8










I
1
SJKGE
Hot detected-2.0 ug/hr












HEX
0.5 ug/hr












GEHBJL IWFO«31TIO>
Ccipound related to norial
•etabolisn. Ho other details given
Cryogenic sampling technique.

Sealthy military and civilian
eiployees. U.S. lir Force School of
Aerospace nedicine, ages 23-il'7 yr. 3
siokers.
IISIME5: CBICBIHITIB HTDBCC1BBOSS;
CG10SIHE OESinC COBPOnKDS;
CElCBOBSlimtS; FLDCTHE COaPOUKDS ;
ISinH; XICCBO^S; THIS; ITBITS

BEfERBKCS
Cockle, J.P.
Canp, B.J.
Delch, B. E.
197S
Archives of
Environnental Health
30(21:290-295






-------
Icetic acid, propyl ester
1C9-60-4
CE-B10-02
BS 102.13, (!E -92.5 C, BP  101.6 C.  It 40 •« Hg at 28.8 C
                                                                                      (COITIROZD)
1ISSOB
3514
Breath

ZT.POSOBE BOUT!


AUITTICAI
BETHOD
GC-BS

HOBBIB
OF CJSSS
54 (387
sai pies)

BHGE
Not given

BEi«
2.» ng/1
Geometric

GEH5AL IKFOBBATIOH
Measured at 25 C and 760 •• Eg
49.4* occurrence
letter and upper one-sigaa liaits 1.1
ana 5.2 nq/1
Healthy* 18-35 yr old, nonsioking,
acfcan blacks and Caucasians.
Chicago, II. Rigidly contcolled
ISEITH; A1CCBOLS; ILLIHOIS; ADULTS ;
CELOBIHATEC BTDEOCA5EOSS; TOHTIl!
CEGtlTC COHECH!IDS: BE1LTH BI2JECS;
HB«liTIOI(: BETJEOLISS: BETASOLITES;
ECPmtTIOl EIPOSaBE; HBBAH IBEtS
SEFEBEHCE
Krotoszyoski, B. K.
Braneaa, G. H.
O'Seill, B. J.
1979
Journal of Analytical
Toiicology 3:225-231

 cetic acid, thio-  (8  CI>
 thanethioic acid  (9 CD
 07-09-5
 :-H»-O-S
 « 76.11. HP <-17 C, 3? 93 C, TP 1 » Hg at 50.0 C
USSOE
3515
Breath


EIPOSUBI BOOTE



KltTTICtl.
BETBOD
GC-BS


KOBBES
0? C4SSS
5» (387
saiples)


B»KGE
lot given

1
MEtS
3.7 ng/1
Geoietric


GEHEE1L IBF08B1TIOH
ecasured at 25 C and 760 n H
-------
    Icetlc acid,  trichloro-
    7«-03-9
    CI-B-C13-02
    St  163.t3. If 57-58 C,  Sf 1»*-197 C
                                                                                         (COMTITOBD)
1 TISSD1
I

~
3517
Brine













EJfOSOBt ROOM IWITlcre
BETBOD


Inhalation EC






















BOSSIS
or cisss


s










1
1

1

1 i

3518 1 fhotoaetrr 1 2117
Brins 1
1
1 1

1 1




1
I 1
sitai



a; 99-5 mg
b) 5-65 119 '















-

less than t->500 mq/l











BUB 1 GEXIEIL IfFOBBaTXOB 1 BEFE5EICZ
1 f
1
I
a) Hot alien I a) Day 5 and 17 of 50 PP«
b) Sot gi»en 1 tricaloroettrlene. 6 iir/dar, on 5
| cctioecati»e days. Initial Talae, 20
1 *4 an day 1
1 t) 1 and 1« dars after 50 ppl
1 tricblaroetbfleoe, 6 tr/a«r, on 5
1 conseeatiie dars. plus etkanol
1 pretrejtaett. Final raloe, 7 aq on
I d.T 1«
I 2* br excretions
1 latinated frcm orapb.
1
1 20-26 T? old students, *t €2-77 kg.
1
1 CBtOBIBlTri BTDIOCUBOIS: IICOBOLIC
I BiHBKis; Biooi; Bicor PI.ISBI:
1 OBHE; BBHB01ITIS: BITIBOIISIf:
I ICOtTS; seism
1
1
•ot ?irea I Jfter erposare to trjcfiloroethrJene
j [at* also qiTen for age- and
I sei-specific aactalitr tram aeopltsms
| nd total icrtalitr >s coipared «ith
I portalitr of Finnish population.
1
I Iges V5-65 rx or aorc.
1
| riBUBt; JDDIIS; OEISE; COBPIS1TITI
| CIIIOITIOBS; CHLOBIIIS CBGJUIC
| CCBICHIDS ; IJCffSTBIH 1TBOSPHFBES;
1


Bailer, G.
SpassavsXi, B.
Benschler, D.
1975
Irchives of Toxicology
33:173-189














Tola, S.
Tllhanen, B.
Jfttvinen, E.
KorSala, a.
19BO
Jqoinil of Occupational
BeSicine 22 (It) : 737-700




	 t
                                                                                                                                                                                             oc
Icctoacetic acid. b«trl ester  (9 CD
Eatanoic acid, 3-oxo-« fcutTl ester  |9 CI)
5S1-60-*
   1«S. 20,  BE -3S.6  C,  DP
ussai
35t»
Bceata
I
IIKtSOBI SO9TI


AIlltlJCAI
BET9CD
GC-BE

BOBEeB
or cjsss
S« (387
salples)

J1FEB
lot givea

»!i» I or»fsn ijrrosaifior
t
i
I
0.192 tj/1 [ fejsnrej at 25 C aad 760 >i B?
S«oiettic 1 19.1V occocrence
1 lover ana eppec aoe-Sigma liiits
1 0.059 as a O.€13 aq/1
(
1 SealthT, 18-35 re old, nonsiofcinq,
( attta clactf and Caucasians.
1 Chicago. II. SiqidlT contcollea
1 «iperi>egtal cocdttions.
1
I ISUTH: HCCEOir; TIUSOIS; MH1IS;
ICELCftllkTII ETDPOC1SBORS; 1011TILE
1 CIG1B1C COJPCU1DS; BEaLTB «IZ15tS;
1 IHILITIOIt BIT4E01IS1; HIT4EOLITE5;
f eCTULttlOl EinsniE; DEBill IBI1S
L
lire sires
FrotosjTDEki, 3. IT.
Euneau^ S.9.
C'seill, E.J.
1971!
Toiicologj 3:225-23*
-------
lc«tOM 18 Cl)
2-PtOBaiOM  (9 CI)
«7-««-1
C3-I6-0
81 58.08. IP -9«.« C. BP  56.«8  C.  fP «00 •• Ba at 39.5 C
1ISSOB

3520
EE«ltk




3S21
Breath










3522
Breath







.




3523
Breath










EZFOSOBE mrai

-











































alllTTIClL
BRIOB
OC/HS





GC/BS











GC-HS













GC











inaeia
or c»sss
-
13





8











5« (387
saaples)












a) 5
b) 5










IllGE

0.22-4.87 pps





1.3-2000.0 ng/hr











lot given













a) lot given
b) lot given










RIM

0.52 ppn





500.6 ag/ir











101.3 ogA
Seaietric












a) 309.0 * or - 3.1
nioleVl
b| 20.3 * or - 3.1
moles/1








entni. nroiiiTioi

comctea fci level it inhaled aic

EealtkT alalt>

siBDBi; loitis: ansinzBZii BRBODS;
IIIBHOl
Ccipoma related to noiaal
ntabolisi. lo other details givea
Ccyoganic saepliag techaigne.

Bealthy ailitary and clTilUn
eiplorees. O.S. llr Toroe School of
leco^paec Heaicine, ages 23-47 jr. 3
tickers.
EIKIIBS; CBIOBIItlH BIBBOC1BBOIS;
CBLOBIII OBGIIXC COBPOOIDS;
CBtOSOBIIZEIIS; FL001UE COBFOniDS;
EBIITB: IICCEOLS; TZXIS; 1D01TS
«ea«Eed at 25 C and 7CO •• flg
lOOf occurrence
lewc and upper one-Siqu liaits 5«. 6
aid 181.7 gg/1

Bealtkr* 18-35 Tt old, nonsiokiag.
oxfcaa blacks and Caucasians.
Chicago, It. RigidlT controlled
eiperiaental conUtiona.
tIEITS: HCCEOIS; I1IIIOIS; ID HITS;
CElOBIllIir BTDEOCIBBOIS; fOUTILE
cioiiic coipomiDS: HHITH H»I»BDS;
IlHlIiTICl; BETIEOLIS8; HZHBOLITBS;
ECPU11TIOI IIPOSOSE; Visit SBIIS
a) Snblects taking 250 ag/day
tulfiraa
b| Controls
Significant increase (P < 0.001) la
drag-treated subjects.

lea-fasting sablccts. ages 25-«a jr.
taking dicalfiran for treatneat of
alcoholisa fee 1-7 so. (ornal.
ion-fasting controls, ages 20-55 re.
[BOG TUtlPT; Hf»ESOTa: » DOITS;
INKS
BiniBlCI

Jansson, B.o.
larsson, B.I.
1969
Journal of Laboratory
and Clinical Bethods
7« (6) -.961-9(6
Conkle, I.P.
Canp, B.J.
Reich, B.I.
1975
archives of
Environmental Bealth
30(2):290-29S





Rrotoszvnski, B. K.
Braneaa, 6.1.
d'leill. B.J.
1979
Journal of Inalytical
Toxicology 3:225-23*








DeHaster, E.G.
Kagasva, B.T.
1977
Research Coaannicatioas
in Caeiical Pathology
and Pharaacology
18(2):3C1-36«





-------
  icetonitril*
  7«-«S-8
  C5-B3-I
  SI 41.05.  IF -45 C,  IF 81.1 C. TP 100 •• Bg It 27 C
TISSUJ
3524
Breatt






ZIPOSOBJ BOBIB







iiiinicaL
HIT BOB
6C-BS






IBBBra
OT C1SE9
54 (387
sanplea)






I1IGI
lot jiie«






BUI
7.4 ng/1
Seonetrle






GIHMl motlallOl
tcanrcd at 25 C and 7«0 nn Bq
19.4* oecnirence
I»»er and upper one-sigsa Units 3.0
and 16.0 ng/1
IMltny. 18-35 re old, nonsnokinq,
oi Ian blacks and Caucasians.
Cklcago, ii. Eloidlr controlled
«ip€rlnentnl conditions.
ItZITB; klCOeOLS; IILIIOIS: UILTS:
CElOBUlTfO BTDlOClBBOIS; JOlaTIlE
CES1IIC CQBPCUIDS; HltlTB BlllSrS-
IiaiLlTIOI; HttlBOIISH; «BT»BOIITIS!
ECPVL1TIOI HPOSOBB: HUH 1EEIS
itmssct
rcotoszmski, 8.K.
Brnnenn, S.s.
c-it«ill, a.J.
1979
Journal of analftical
Toxicalogr 3:225-23*





         , dlchloro-  (8 CI)
        aictloro-  (9 CI)
7«72-29-»
CJ-C12
If S4.9t, IF -«6 to -C«.2 C

3525
Sreatli


nrracB
oc-as
or ctsis
54 (387
saaples)

lot jirca
•si" i eimii itroxBiiioi
i
10.6 nq/i | Beasarel at 25 C and 760 an Ea
Seonetric | tf.»» occerence
t Io»er and npper one-sioia liaits 2.8
1 and 41.9 Dq/1
1
1 lc*m*. 18-35 1C old, oonanoJtlK,.
1 irtan blacks and Caucasians.
1 Chicago, n. Bidiilr-controlled
1 eipcrlnental conditions.
1 HIITR: 1ICOEOLS; IILIIOIS: 1BB1IS:
1 CELOKIMTH BT080CJB9OIS: TOlaTIlE
J CIBMIC COBPTOIDS; BMIIB giZlBES;
( II»LaTIO«; HCTIEOLISB; BII1BOLITIS-
1 EC?011TIO» EIPOS08B; OBB»» 1BB1S
BlFEBtfCI
rcotasTTnskl, «.)!.
Bmnenn, G. 8.
O'leiii, H.J.
1979
Journal of analytical
Toiicolo^r 3:225-234
-------
llaaiaa, 3-lMthTltkle}-, t- (8 CI)
l-CT*tOla«. S-MtbTl- (9 CI)
1187-8*-*
c*-i9-t-o2-s
II 13*.20
1ISSOI
3126
oriaa















BI tost is BOWK
Inhalation















iiiinicii
BETBOD
CC















•oaazi
or cisss
a)
b)
c)
d)

n
91 7











IIIGI
a) 100-475 aaol
b) 200-425 aaol
c) 25-90 aaol
d) 175-415 aaol
•) 2*0-675 uol
f) 40-150 aaol
all are /aol ereatlalae










- -
nil
a) 336 BBOl
b) 3*0 aaol
c) 38 aaol
4) 289 aaol
e) SI 2 aaol
f) 72 aaol
«) «S » or - 23 aaol
111 aM /aol
creatinino










GIIE111 IBPOIB1TICI
a) Bethyl ckloride aiposue, 30-70
KB
b) Retkyl cklorido exposure, 30-50
KB
c) Mtkyl eklorida oapoaan, 40-40
EFB
d) flctkyl cklorido oapoaaro, 40-70
a) Sotkrl eklorida exposure. 35-65
Fpa
f) Batkyl ckloride azpoaar«. 50-90
q) coatrcl
laaple* taken 2X/day 7 days
Ckaalcal plaat vorkera
IITIEKIIIOS; 1DOLTS; VIIBE: 1E1LTR
Biiisos; innsniu MBOSPBIBES;
IIBU1TIOI; IET1801IIES; CBIOIIIITED
BItBOC>B«OI5
1
BEtEBEICE
Tan Doom, B.
Bora, P.J.I.
Benderaoa. P.I.
Beavara. J.
Tan Borgia, T. J.
1980
International IrckiTaa
of Occapational and
EBTironaeBtal Bealtk
46:99-109








llaaln, 3-l«-C*-kT4ro>r-3-lodopbaaoxr1-3.5-Uloaopaanrl|-. 1-  18 CH
l-Trroaia«, e-(»-kT*roiy-3-lo4ojko»Tl)-3.S-411odo-  (9 CI)
CEU-02-3
C15-812-13-1-0*
II tS1.01. tt 236-237 C (lac)
IlSSflt
352T
Blood,




tlKSVVS JOOTt






iiitmciL
HCTHOD
III





•VIBZS
or cisss
a) 2*3
h) 42
O 27
d) 22



»MS
a) 80-250 aoytOO al
b) 273->1»Ofl no/100 al
c) < 36-145 og/100 al
d) 174-410 (0/100 al



BE1I
a) 183 B4/100 al
b) lot giTBB
e) lot jlTon
d) 275 aq/100 al



GIIHU IirOSBlIIOI
a) CatkTtold Tolastoora
b) Hypoctkrcold patioata
c) HTpotkTTCld pattoata
4) Boraal, proqaant mien
Halt of dotactloa, 36 nq/100 al

iciBoiis; iiisoiBmt BRBODS; BLOOD
SIBOS: TIMS
(ETEBEICB
BtO*Bl I.I.
BotkeaBT> •>•
197*
Joaxaal of
Pkaraacoatical Sclencea
63 («): 1214-1217


IllTl aleokel (8 CI)
2-Itoiwa-l-ol (9 CI)
107-18-6
C--86-0
» 58.08, » -SO C. BP 96-97 C. TP 10 aa fq at  10.S C
1ISSOB
3528
tiaath









EXtoson mm










tin men
BETBOD
ec/ns









inan
or cisss
8









11TCI
«ot d«t«et«d-9.S ui/kt









•Ell
1.3 no/kx









etiitii iBroiBinoi
Ccipoaad relatad to aozaal
•otabollaa. lo otkoc detailt 9lT*a
Cryogoalc aaapllai tockuiqne.

••altkr ailltarr and elTilian
«aplOTMl. D.S. lie force School of
Icrospaea n«liclo«, aq«s 23-47 TT. 3
aaokeca.
EllZNCS; CIIOBIBKED BTDIOC1BBOIS;
CBIOBIII oieinc coipomnis:
CBtomiBiziKS: FIIOBIIS coamms;
IBIHI; 11CCBOLS: TZMS: HOHS
IEIBIEICS
coakl*. i.e.
Caap, S.J.
••lek, I.E.
197S
IrekiTca of
EBTiroaautal Boaltk
30(21:290-295





-------
linings
7*29-90-5
11
lt» 2«.98151, » «60 C, BP 2327 C.
                                   TP 1 •• Ig at 15*0 C


:
TISSai EIPOSSSI ROOT!
lorta
1
1
3 5 JO
51004,
sera a
31
rod.
2
1
1
f
1
1
1
1
1
1
1
1


1ULTTIC1L
BETBCD
11
US
1
t
us
115
I OH BIB
OF C1SBS
2
1
a) «
b| 69
c) 23
U f«
It 30
:J 57
1) 3g
E1IGS
8.5-20 ag/s [net vt)
a) lot applicable
b> lot applicable
c> lot applicable
d) lot applicable
a) Vot given
b) Sot given
c) lot given
>t lot giTei
>) lot given
:J lot given
[| lot given
BUI
11 » or - 8  I Hodge, K.C.
desCerrioranine I 1^80
d! Final leasareaant, dar 290 I lancet 2<8196) :692-693
Levels sLoaed sbort-teca cyclic 1
•artatlags, and long-tera opvard 1
trend luting treataent. E3tiaated t
(cos grapb. 1
36 Tr old aen vitV dialysis |
encephslopatbv. |
1
Irileptlc seizures, svoclonlc larks, I
CialTsis eaceptalopatkr, 1
etteodvstrachv, prosisal aiopatliT. 1
1
noiiim; i»troos STSTEB OISEISZS; I
BiTODiiiisis: anus; DSITID KIIGQCB: t
EtOCD SEBHI |
i
1
a) controls I Gilli, t.
b) Drenic patients on besodlalrsis. I Farlnelli, 1.
Elalrsate. 7.7 * or - 7.51 og/1. pH | Fagiali, I.
7.3 I DeBastlani, P.
c) TIretic patients on internittent I Rnoncristiani, 0.
rerltoneal dlalrsls. Dlalrsate, 10.07 I 1480
« or - 5.3 ag/1, pa < 5.5 | lancet 2(8197) sT»J-7»3
>IDIET DI SEISES; 1LOHI»DB; IRltS; I
HCOB SEltll; ITIII: BIBOD111ISIS t
1
t
i| Control: fron U.S. I llfroy, i.e.
t) loalialTZcd patients 1 Regg. 1.
c) DialTT«d patients I Crasvell, p.
encepItalopatliT t Inerican Journal of
1 Clinical nutrition
Orealc patients in U.S. and 1 33:1509-1516
Instralia. Sose died of dialysis I
msTmti: limit STITES: nno?siEs: i
IIIOIET OISIISES; 1EETOIS STSTIB |
CTStlStS; BOIES; BBlT-f; 8E1BI; LITER; 1
uses; losciis; S?LIEI: EEBCDIILISIS: i
ItC Slim: HE11LS |
1
-------
llCliniB
II
Itl 26.981S4. -IP 660 C. BT 2327 C, T?  1 ••  Hg  at 15*0 C
                                                                                       (COBTIigSD)
1ISSQB

3533
Sralo

















3534
Praia











3135
Bair















3536
Hair










EXFOSDSE BOOTS





























































iiittncu
BETHOD
11

















US









































ItllBES
or CISES


















a) 16
b) 30
c) 57
d) 38


























-
a) 42
b) 40










llBSS

a) 8.0-19 gg/g (rat vt)
b) 22-23 ug/g (vet vt)
c) 6.9- 15 gg/g (vet vt)
d) 12-22 ag/g (vet vt)
















a) lot given
b) lot given
c) lot given
d) lot given



























a) 1-17 ag/g
b) <1-29 ag/g









(HIT
Bill

a) 15 » or - 4 «g/g
(vet vt)
b) 23 » or - 1 ag/g
(vet vt)
c) 11 * or - 2 ag/g
(vet vt)
d) 15 » or - 5 ng/g
(vet vt)












a) 2.4 * or - 1.3
b) 4.1 * or - 1.7
no /kg
c) 8.5 » or - 3.5
•q/kg
d) 24.5 « or - 9.9
•I/kg
Defatted saeples






















») 5 ug/g
b) 5 ng/g
ledians








?HS!)
GE1IB11 IIFOSHMIC1

a) Bales, eerebree, 9 sabjects
t) Teeales. eerebmn. 2 sabjects
c) Bales, cerebellum, 6 snblects
i) Tenales, cerebellua, S subjects

Tron a groat of 61 autopsies.
forensic nedical eianinations, Japan.
Bales, nean age 40.6 rr. Feiales,
nean age 37.4 vr.
T11CI niBtllS; 10TOPSIZS; JIPII;
iioBiinB: iBSERic; CIDBIUB; COBALT;
etBCain*.: COFPZB: MOB; BSBCUBT:
IIBIUB; BlGICSIUfl: BA1611ESB:
IOBIDIOB: iniBoit; sciiDing;
siLEBioB; Timim: TiiioioB; zinc;
GCLC; BBOBIII; lITEli KT91ITS;
CIBEBBH1; CtEIBEHTIB; H!1BT: [HJSCLES;
FHCB11S; SPXEEp; 1I1GS; lOBll;
BITH.S: coipiBHTirs ETiLomcas: SEX;
rcBEisic BICJCHI
a) Controls fron O.s.
r) londialvxed patients
c) Dialrxed patients
d) Bialried patients vith
encephalofathf

Oreele patients in O.S. and
lastralla. Sone died of dialysis
encepbalofattT.
lOSIDlLII: 01ITED STITIS; 10TOPSIES:
II It BIT 9ISE1SES; HIBTO03 SIS1EB
CISI1SIS: BCBES; BB11J: BEIBT: LITEB;
IBISS; IDSCltS; SPlItiT; RlilODIllTSIS;
1IBBI1H!!; BEIU.S
leviev. 24 representative
cte-aaaly*is treataents are
tabulated. Ibe feasibility of a
bclistie, no-vash policy for bair
analysis is cut lined and supported.
ftTIEv; TP1C! riMEITTS; BUB;
mSTfiH.lt; atlSO«EBEIT NETBOOS;
gitus: pBoums; COBPIBITITE
IISEIIC: B»BKIS; BBOIIIE; ClCTlm;
cucin-i; cHicEiiE: CBBOHIIIB: COMIT;
CCPPH: SIIH0B: sEBBtnvi; eoiD:
icon!: IBOI: iiiTHiinB: lilt:
BI61ESI»; BU61I2S1; BEBCDBI;
tClTB9E!TJB: HCKtl: PBOSPHCBOS;
iciisstvii: BUBIDIOB; snumB;
SIUC01: SIIVB5; SODIVB; SIBCIIIIB;
tlic: ilacoiion
a) Controls
c) Boltitle sclerosis patients
Saaples fren 7 scalp sites in each
•vc^ect.

CI11B1; 1E01IS: CEITBll BtBVCOS
!TSTZ9 DIS'JSES; 3»IB: KIDBIBU!!;
IlCHIIt; C1ICIOB: CB10BIBE: COPPER;
ecu: Km*!: >iiisiiis:; IESILS;
S1I»«11!; SIITEl; SCDIOH; SOIF3B;
71110131; TIIC

BEIBBEBCE

Tvkava, B.
snzaki-Iasaaoto, B.
leaao, 1C.
Terai, B.
1980
1 retires of
Enrironnental Health
35(1):3«-44


•









Alfrey, I.e.
Heqg, 1.
crasvell, P.
1980
laerican Journal of
clinical latritioa
33: 1^09-1516







cbittleboroagh, G.
1980
Science of the Total
Environment 14:53-75













Byan, D.E.
Bolzbecher, J.
Stuart, D.C.
1978
Clinical Chemistry
24(11):1996-2000






-------
II mi cai
7g29.90-5
II
Its 26.98154.
              HP 660 C. BP 2327 C.  7P 1  •• Ha, at 1590  C
                                                                                     (COITIIOBD)
1I3SOS

3537
Beart

















3538
Mart












3539
Kidney


















BIPOStJBS BOOtS






















































atunxcii
IRBOD
U


















1>3













U



















BOMBS
0? CISBS
a) 4
b) 2

















a) 16
b) 30
c) 57
4) 38










a) 6
b) 2


















sues

a) 4.7-26 ug/g (net «t)
b) 23-34 a«/9 (oet «t|

















a) Hot given
b) lot given
c) lot given
d) lot given










a) 10-41 ag/g (net »t)
b) 12-12 ag/g (net lit)

















flEIT
•Ell

16 » or - 9 ug/g (««t
•t»
b) 29 * or - 8 ag/g
(«et »t|















a) 1.0 * or - 0.8
eg/kg
b) 6.9 » or - 10.6
ag/kg
c) 22.5 » or - 20.5
aq/kg
d) 42.7 « or - 22.9
•g/kg
Defatted saaples





a) 20 » or - 11 og/g
(vet »tj
bj 12 * or - 0 ag/g
(vet «t)















PIGB)
GEIIBll nPOBUTXCB

a) Hales
1} resales

tcoi a <|coap of 61 autopsies.
forensic aedlcal examinations, Japan.
Bales, aaan age 40.6 ft- Females,
•ean age 37.4 vr.

1B1CB EI.BBZBIS: 40TOPSIBS; J1P1S;
iioBUns; iBsziic; CIDUOB; COBILT;
CEBOSTBB; CCPPBB; IBOB; HEBCOBI;
IltlOH; IfaGBZSIVB; UBeiBBSB;
BOEIDIOHl IBIIBOBT; SCaBDIOB;
SntBIOIt; TIIMIOI; TABIDIDI; ZIBC;
«cit; BBOHUi; tirra; KIDIBTS;
C1BBBBOB; ClBEBniOH: HB1BT; BOSC1BS;
SIICBBU: SPIEM; LOK3S: 10BT1;
BRILS; COBPUMIV8 BVilOHIOSS; SSI;
fCBJISIC BiriCIBI
a) control! tiow 0. S.
t) Bondlalyiei patients
c) olalysed patients
d) Halted patients >ith
•acephalopatby

Dteiie patients in O.S. and
lastralla. Sone died of dialysis
encephalopatfey.
losnuii: omsD SHTBS: IVTOPSIBS;
HC8BI DISBISBS; IBBVOOS STSIBH
tlSHSBS! BOIES; BEIIH; BElBTt 117 IB:
loses! nosciis; SPLBB>; BBBODIIITSIS;
11CBIBHB; BB1US
a) Bales
t) reiales

fron a gtonp of 61 autopsies.
forensic ledical exaainationa, Japan.
Bales, aean age 40.6 yr. Feaales.
aean age 37.4 yr.

1D1CE BLBHIITS; IOTOPSIBS; JlPH;
HOnBDR; IBSIHICJ CiDBIOB; COB1LT;
CEBO»IUR; CCPPBB; IBOB; BBBCOBTj
1BIIOS; BaGIESIUB; BalGaBSSE;
fnEIDMB; IBIIHOBT; SCaHDIOB;
milTOH: TT1MIOR; T1BIDIOB; ZIBC;
CCtll: 9BOHIBE; LIVES: KIOIETS;
CIBZBBOB; CBBIBELUJB: BE1BT; HOSCISS:
fllCBBIS: SflEBB; LOBSS; JOBTi:
BITUS: COBPUtTITB BTAIOATICHS; SEX;
PCBBKStC HIEICIHE

BBFBBBVCB

Tnkava, B.
Suzaki-Tasanoto, B.
Isano, R.
Terai. B.
1980
archives of
Bnvlronaental Health
3S(1):36-i)4











alfrey, I.e.
Regg, 1.
Crasvell, P.
1980
liecican Joornal of
Clinical Bntrition
33:1509-1516







Tnkava. B.
Sazaki-Tasaooto. n.
liana. E.
Terai. B.
1980
archives of
Environaental Health
35(1): 36-40












-------
llaelaas
T«29-90-S
II
Itl 2C.9S15I. It CCO C. If 2327 C. ft 1 M Ba It  ISM C
                                                                                      (CORIIOED)
1XS39I

35*0
llvor

















35*1








35*2
Lviq

















35*3
Lung








NCOSOIS 1OOT1























































1I11TCZCAL
BCTBOD
•1

















us








•1

















us








IBBBM
or CISBS
a) 9
b) 3

















a) 1«
b) 30
4 57
d) 38








a) 2
b) 2

















a) 16
b) 30
d 57
d) 38








B1KB

a) 10-25 ag/g (vet *t)
b) 5.5-20 ag/g (vet vt)

















a) lot given
b) lot given
c) lot given
d) lot given








a) 18-100 ig/g (wt vt)
b) 10-23 ag/g (vet vt)

















a) lot given
b) lot given
c) lot given
d) lot given








RZ1B

a) 18 * or - 6 ag/g
(vet vt)
b) 15 * or - 7 »g/g
(vet vt)















a) ».1 » or - 1.7
b) 25.5 « or - 33.1
agAg c| K1 * or -
12* ng/kg
1) 301 « or - 21*

Defatted saaples






a) 59 » or - 58 ag/g
|v«t vtj
b) 17 » or - 9 ag/g
fvet vt)















a) »3 » or - »3 ag/kg
b) 75.2 » or - 77.3
•g/kg
c) 89.5 * or - 76.8
1) 215 « or - 220
ng/kg
Defatted sanplea.





SEIIIll XBFOIBHIOB

a) Bales

Iron a groap of 61 aatopsias.
forensic nodical •xaninatlons. Japan.
Bales, aeaa age «0.6 jr. fesales.
seen age 37.1 yr.

IBICB xiSBsns: IOTOPSISS; JIPIB;
llOBIRvB; IBSniC; C10RIOS; COBUT:
CBICRina; COPM1; IIOI; HBBCVBT;
HtlDB; SISIISIOH: R1IG1IISB;
inEIDIHI; 1ITIROBT: SCIIDIOR;
SHEim; TITIIIOR; TIHDIUB: Hie;
eciB: Btoiiit: um: KDESTS:
CIBZBBM: ciBZBEiuiR: BEIBI; HOSCLES;
E11CBI1S: SPtBBB; LOBGS; 1CR1;
IRUS; COflPUlTIVB ByilDlTIOBS; SSX;
ICIIISIC BKICIIB
a) Coatrols froa U.S.
t| loaaialyxed patleats
c) tlalyzed patioats
4) Blalysed catiaats a 1th
eieepkalopatby
flrenic patleits la O.S. and
laatralia. Soae diad of dialysis
eaeepbalopatby.
llSnilll; OUTID STIIIS; lOTOtSIBS;
If DIET BISB1SB5: RSTOOS STSTBR
t is lists: BOIES; mil; BBIBT; iirsi:
IDIGS: Rosens; SPLIE*: HHOtimsis;
I10IIIOR; H1111S
a) Rales
1) Teaales

froa a groap of 61 autopsies.
forensic aeUcal oxaaliationa, Japan.
I tics, lean ago *0.6 yr. Peaales.
aeaa age 37.* yr.

T11CB BIBBBItS: 10TOPSXZS; JlPHi
iioniins; IBSZIIC; CIDRXDR; COBUT;
cc
-------
ilmlm
7«S»-«0-5
11
Itl 26.9815»,  at 660 C, BP 2337 C, TP 1 •• Bg at 15W  C
                                                                                   (OOVTIBBXD)
IISSBE EirosotE BOWB IBUTIICU
BETBOD


35«» Ba
BaBcte













1
1
j


3515
Basel*
1















US


I
f
1
1
1
1
1 1

t





35« u
BttBBSJ
or ctsss


*1 *
b] a


















) i«
1 30
) 57
1 38












1115! |
1

|
a| 8.3-16 gg/g («et >t| 1 a| 13
b) 7.4-29 «g/g (Mt >t| 1 (rat
1 b) 17
1 (*et
1
f
1
1

1
1

1

r
i
i
i
i
i
a] lot gtrea I a) 1.2
b) lot livei | 11/tg
) tot glrea I 6) 2.S
) Bot given | eg/kg
I e) 9.1
1 ag/ltg
1 d) 1«.S
t e?/'Jt?
BE1B | SHIIlt moiBHXCI
1
1
1
+ or - 3 ug/g f a) Bales
vt) 1 II Tevalev
+ or - 7 ug/j t
vt) 1 fro i * ?rc«f of 61 autopsies.
1 fcreaslc aedlcal exaaiaationa, Japa
f a*a2*av tutt a^e 40. C fr* faaalea.
I aeaa a Ualraed patleats
1 d) Clalned patieata vlth
« or - 14.6 | encephalopatbr
1
* or - 13.7 | Create patients la (r. 3. aad
; Joetralia. So»e died of dial/aix
I
1
1 llfrei. I.e.
1 B«gg. 1.
1 crasrell, f.
I 1980
1 laerlcan Journal o
i clinical (otcitioa
1 33:1509-1516
i






t



I Defatted sanples eaccpfcalopatlf. 1
1





t
1 1
5 1 a} 9.3-30 nq/q fust vt> la] 15 *
Pancreas 1 1 t) 2 I b) 18-25 «g/g (vet vl) I (ret «t)
1 II »> 22 *
I f«at vl)

i
1


1
1










insTBiLii; nme STITIS; JBTOPSISS,-
Kinzr DISUSES: IZBTOOS SHTEB
CISUS'3; BOIES: BBalf; 1Z1IT; UTJB;
I1BGS; BOSCLIS: SPLEII; HSlOIIlltSIS;
lIOBinB; BE1J1S


or - 9 pj/9 1 •' Bales
| t) Teaales
or - 5 ag/g 1
f tram a graft o- 61 autopsies.
| Coreaslc avdical eiTaaiaatioar, Japan.
1 Bales, swan ag* *0. € rr. Peial«8.
I aeaa ag« 37.* TC,
1
( SMC* nlBEBIS; ItlTOPSIES; J1T1I;
| IIUBIITB: ItSEBIC; CaDBIOB; COBllT;
| CESCflll': CCFPBB; IBOJ; REBCOEIi
| IBDIH!I; IlCBZSItIB; B1BS1BZSI;
| SOBIDITI; linBOIT; SC1IDHJB;
| SUHI11; Tinting; fl I1BIOII; ZIIC;
t fiCID: BBOBIBI; I.ITEE; XTOIETS:
| CltEBRlH: CIBtBEUOB; BSlIf; BVSCLXS;
I >1ICIB»: SPIXE*: lOKS; lOSTl;
| BIT11S: COBPU1TITE CTILD1TIC1S; SIX;
| fCIIISIC HICICIII
|
t
1
t
1
1
1
I
1
1 Tokava, B.
t Sazakl-Tasaaoto, I.
1 laaao, t.
1 lerai, B.
1 "BO
1 IrctUes of














1 lOTlronaental Bealth
1 35(1):36-««
1
1
t
t
I
f
1
t
1
1
|
1













                                                                              (Btlt PtGt)
-------
7129-90-5
II
Itl 26.4115*. W 660 C. BP 2327 C, fp  1 aa Hg  at  1540  C
nssai

3547
Splem

















35*8
Spleen













Exiosns icon



































alUTXICU
IR10B
u


















us














BOBBIE
or CISES
•I s
b) 3
















'
a) 16
b) 30
0 57
1) 38










1
11ISI

a) 6.7-25 ag/g (««t «t)
I) 16-»4 ag/g («et it)

















a) lot gi»«i
b) nt gl»««
O lot gif*B
d) lot gi»«











RIM

a) 14 + oc - 8 ng/9
(net lit)
b) 26 * or - 16 *J/g
(»«t rtl















a) 2.6 » or - 2.1
•i/kg
b) 35.3 * 01 - 72.3
•9A9
C) 2»3 » or - 250
aqAg
3) 493 • or - 463
•9 A?
Mfattcd saiplaa






CtllllL IlTOlSUIOH

•} lain
t) f«Ml«S

Txoi a gcovp of 61 attopsics.
fot«»lc aeileal axaaiaatloia, Japan.
Bales. Ma> «g« «0.6 yr- r«aleB.
•*a> «g« 37.4 TT.

»ici ncims: IBTOPSIIS; juu;
ittnna; iismc; cutiva: COBILT;
CtBCSIBS; CCPPHJ I10PJ B1JCUI1;
IICIH«; laSIISIOB; nlURESI:
»UBiT)in»; ininont; scuoira;
itiinaHi TiiuiDi: TIHD«B: zinc;
CCID: BBOBIItS HTBB: KIDBITS:
CIBBBBCI; citniiiaa: BEIBI: susais;
EUCBZI3; spun: IDKSJ ICBI*;
BITUS; COIIPUHin ETJLniTIOIS: SXI;
TCBIISIC KBICIIX
a| Controls flroi 0. s.
t) tmtitlmS patl«nts
e) ui»lri«a fatluts
d) DlalT>td patltnti «lth
•accpaalopatkT

Ircslc patients ta U.S. asd
Usttalla. Sow di«d of dialysis
•aecpaalopatkT.
lostBiui: miTED STiTis; inapsiss;
IIC1EI DISUSES; niTOOS STSTI9
rijzisis: BOIES: BIHI; min; IITBB;
inss: aosciis; SFIIBI: BEBODIIIISIS;
iitniw; units

BIIEIEVCE

Takava, B.
SoiaKi-Tasnioto, a.
liana. It.
T«al. B.
1*80
Archives of
tSTllonieBtal Baalth
35 (1(: 36- 44











tlfMT. »-C.
B^g, i.
Ctasvell. ?.
1980
laericaa Joarnal of
Cliaical Bntritton
33:1509-1516








1318-09-8
IIKT CODPOSmoi USR1IOII CB DIBBTMBIIBB
nssnB
3541
latastlie


ZXtOSOBZ BOOt!
Ingest Ion


MHTTICH
nrrncn
tn


BOSSES
or ciszs
a) 21
b) 32


IIIGE
a) lot glT«o
b) lot girtn


•an
a) 0
b) 3.20110(1-5)
flb«u/g
Ish «t
?fe

SHIBII HfOBBlTICK
a) Controls
t) Kesldeiits witb 1014 ten, high
l«tal exposnu fcoi drinking
ccataainat«d «at«r
|gtopsl«s, Jflonoa wall
!!2-89 Tr old rasldeats neat t&conite
Ftocessin? plant, niaatsatt. 17-77 jr
tld controls, IHnnesota and Texas.
eilBESOTl; THIS; aOTOFSIES;
IBIESIIBES; IITEE; lOISS; DBIIUnS
««!•>; HtdSnitl EBISSIOIS;
IBOH5TBIU EC11DTIOB; (aTEB
EC1LDII01: ISBISTOS
-
BETEBEKCE
Carter, B.E.
larlor, B.r.
19SO
Environmental Besearch
21:85-93


                                                                                       (IEI1 ?JGE)
-------
   latklboles
   13 10-0«-e
   mc» COSPOSITIOI oinon 01 mtirninra
iissiiB
3550
tine
3551
law
BirOSOBB lOOtl
laaectiaa
Iag«stion
1
i
1
1
1IU.TTIC11
HB9BC&
N
Bl
•(mm
or CISBS

•1 30
b) 32
UTCB
a) tat givea
b) tot glvea
a) lot aim
b) lot gin*
BUI 1 etIIMl ZtrOBMTIOl
1
I
a) 0.3«I10(l-5) | » coatrola
flbers/g 1 b) lesideats «itk long tera. hivk
bt S.KIIO(B-S) I 1«*«1 ««a»*n lea* IrUkiij
fibers/? | ccnt«iii«t«ii «t«r
t*k *t I Ktopdw
1
t i2-n rr eld nsil«its i«*r tacanlt*
I F'oc««aiiq pl«t, linMCota. 17*77 yr
1 cltf coitrali, Rin*«ot« aid Texas.
1
1 eiinsori: Tizist umrsus;
t itTismis; irrii; luics; onntiie
i inn; iimntxii mssiois:
I IIEOSTMII EO.IDTJOI: HTIi
I icunioi: tmsios
i
1
a) O.SUtOtI-5) I I) Controls
fibers/9 1 t) lesUeit* «itk lo>« tera. blah
b) 16.21110(1-5) I level exponce free drlaxiif
fibers/g 1 ceataaiaated natex
ish »t | lotopaiea
1
I S2-89 ji old resideata neat taeeaite
1 ftocessiag rlaat, liaaeaota. 17-77 rr
1 eld coatrolSp ffiaaesota aad Texas.
1
1 HIIESOT1; IZIISi 10TOPSIBS;
I miSTIIIS; UTZI; tDTCS; DBIHtCTS
1 ntn: itDisniii insstots;
I iievsniit tctmiiot: MTBI
1 ICIIOTIOI: J5HSTOS
i
IBRIBICI
Carter* B.E.
Tirlor, t.r.
19*0
BBvlroaaeatal Reaearcb
21:85-93
1
1
1
Carter, B.E. |
Saflor^ W.F. i
1*80
Earlroaaeatal Beaearca
21:85-93
                                                                                                                                                                                  00
IrlllM, •.••-•etkrle*ebia(2-ealaro- (8 Cl)
I«neaasine, a,«'-a«UTleoebIsf2-chloro-  (9 CI)
101-ta-a
C13-B1Z-C12-H
If 267.2
I IIS301
1
1
1 3552
1 Oriae
1
BIfOSVK! B0«r
laaalatloa
Penal
1 tinmen
I IBTVOD
i
1
Coloriictrr
•maEx
or cuss
*
1 tires
i
0.0«-3.8 a«/l
| IE1I
tot giTea
etiiui iiroiuTioi
lir coneeatratloBS oalr sliahtl;
above tkrestold of detectioa (0.01
>«/c< e) .
Iiposed icriers. lev Jersey
CCCOMTIOI1I BHiUS; OBIIE; CBlOBItE
CISIBIC cotrcnos: BstsmBUR
fKIOnS: UCBSTKIU ReiBII
tETEBnCX
liack, I.I.
1S7«
laericaa ladastrial
HTgieae IssociatioB
JoatMl 3S:*26-«32
-------
intisony
1«40-36-0
st
Itl 121.75, n C30 C, B? 163J C. IP 1 •• 19 at  866 C.  10  •• Bq  at 960
USStJB

3553
lorta
















355*
Brain
















3555
Bale


















BIPOSOJE BOOTE
























































1BUITICU.
BBTBOD
Bl

















Bl




































•OBBSS
OF CUSS
3






















































B1B6B

lot given

















a) Bot given
b) Bone detected


































(IEIT
BBaB

0.01 » or - 0.02 ng/g
(net »t)
















a) 0.01 « or - 0.02
•g/g («et «t)
b) Bone detected

































PISE)
GZBEttl IBPOBSITIOB

Bales

iron n grosp of 61 autopsies.
forensic medical exaninations, Japan.
Bales, sean age 40.6 yr. resales.
i«an age 37. a yr.

II1CI ILEHEBTS; JUTOfSIES; J1P1B;
JIUBIBUB; JBSBIIC; CIDRIUfl: COB JIT;
CBSOaXVB; COPPEB; I BOB; BBBCOST;
IICI01; BlGBtSIDH; B1B61IZSE;
1B8IDI05; IBtXBOBT; 9C1BDXBB;
jiiBBiuB; TITJBIOB: YIBIDIOS: znc;
GC1C; IKOBIlIi LITEB; KIDBETS;
C!BBBBB!l; CZBISEUBB; BE1S1; BOSCLBS;
FIBCBZIS; SPIEEI; IIBGS; 1OBT1;
BIT US; COBf J11TITB ET1L01TIOIS; SEX;
KIIBSIC B1DICIBI
a) Tesales, cerebrvn, a subjects
t) resales, cerebellns, 4 sab-fects

Tton a groa; of 61 autopsies.
forensic sedical exasinations, Japan.
Bales, seas age ao.6 yr. resales.
•ean age 37.* yr.
TBICE EtlRBIISi 1VTOPSIBS; J1P1B;
ItBBXBOB; 1BSEBIC; C1DBIHB; COBUT;
CEBCBIHB: CCPPEB; XBOB; BEBCOBX;
IBCItIB; BlGltSIOB; BlBGiBBSE;
IVEIDIOB; IBIIROBT; SCUDIOH;
SE1BBXUH; TII1BIOB; T1R1DIOB; ZIBC;
ecic: BsoaxiE; LITBB: KXDIETS;
CBfBBlVB; CBBtBELLUB; RB1BT; BVSC1B5;
PIBCBB1S; SPIRB; IDICS: JOBT1;
•IIILS: COBP1B1TITB BT1LD1IICBS; SIX;
TCBIBSXC REEICXBZ
It vie*. 2» lepreseatative
pie-analysis treatments are
tatnlated. The feasibility of a
>«listic, no-«ash policy for hair
analysis is outlined and supported.
IfTIZB; TB1CI IIBBEBTS; HUB;
inSTBUIl; BEISOBBIBBT BET BODS;
EITILS; PBOT1IIS; COBP191TITB
IY1L01TIOIS: 110BIIOB; JSTIBCBT;
USHIC: EJRIDB; BBOIIBB: CJDBIDB:
CHCI01; CBICBUB; CB30BIOB; CO E JIT:
CCPPEB; GI11.I1J!!; GEBB1IIOB; SOID;
ICDIBB; laCB; 11BTR1IBB; lElt;
IIGIZSIHB: BiBOtitsE: BEBCVBT;
BCITBDIBOB; IICKIL; SBOSPHCBOS;
fciissitji; tDBioioR; SIIEBIDB:
SIIICOB; SIITBS; SODIHH; STBOBTIUH;
SVIPOB: TIB; TITHIOB: TOBGSTEB;
E1BC; ZIBCOUOB

IZPZBIBCB

Tokaia, B.
Sazvki-Tasnsoto, B.
Isano, K.
Teral, B.
15-80
Irchives of
ZnTironmeatal Bealth











Tokava, B.
Snzoki-Xasasoto, H.
Inano, K.
Terai, B.
1930
Irchives of
Enviroasental Bealth











Chlttlebocoagh, 6.
1980
Science of the Total
Environnent It: 5 3-75
















-------
;«10-36-0
St
l« 1J1.75, RP 630 C. BP 1«3« C, TP  1 an  89 at  BS« C.  10 us 89 at 960
                                                                                       (COBTUOED)
TISSUE

3556
Bale



















_— .
3557
Heart

















3558
Kidney

















STPOSflSH BOOTH




























































iBimreii
iWBOB





















B»


















B*

















.
SnaSBB
0? CaSBS





















a) 10
b) »

















a) 22
b) 3

















SiBOE

	



















.
_
a) Dot given
b) lot given
















-
a) lot given
b| Hot given

















BBXB
..





















a) 0.01 •» or - 0.02
«a/g (»e* **l
b) 0.02 * or - 0.02
aq/q («et «t)















a) 0.01 t or - 0.03
B9/g (»et »t)
b) 0.01 * oc - 0.02
aq/g (vet vt)















G!BFB»l IHFOBiiTIOH
	 	
1 revie» of >orld lltetatnre on to«
accnivlBtioti an« blocoDCeotietion of
selected to tic trace netals ill bnaai
hair and mils aafl other nansaHin
baicr fact nails* clavs and boofs.
labaiatai by geographic area.
•abjeete. «ei» «qe. axpasate
9£adieotr analytics in ppa* and
anthocity frqn ovec 000 E«tenaces.
tr«ICt; inSlBslUl CUaDat CIHltM.
IHIBICIt BOiCPE; HIttDLE BJSt: Ht»
niiMDt sooia aBEnict; somnist
• Sla; OHITII KIveDOI: OBHED STSTBS;
BUB; JJIIS! BEYICT; ABTIBOBT;
is3tmc; BO BOS: caoiimi: CBHOFntms
ccfitT; COPPIB; IBID: BBBCOBI:
IICFEI; S?lS!lI13nj TIB; TiSADIDH; ilE
FCllBTIOB; IBIBil POP014IICI3:
IIOaCCDIOimOVi BIOIBDICMOIIS; t»«B
tOtlOTIOS; POPOHTICB EtPOSOBB; RlTtR
FC11DTTOH; TB1CE BLBRBRSt BETalS
-
a) Bales
t) F«Mles

FCOl t qtaap of 61 autopsies.
fatensie asflical exaainatlons. Japan.
Bales* a«ao age 40.6 ji, Feaales*
lean »q« 37. 4 yr.

TB1CE 8189EI1S; JTITOP3IBS; J1PM:
llOBIIIOilt S8SESIC; CUDBIDB; CD E JIT;
CFSC8HJB; COPPBB; ISO!); BEBCOBYJ
IltlDX; BaGBISIOB; BtBGaBISl:
JCSIBIHI; UTISOBY; SCIHOlOM;
SIllBIOH; TI11RIOBS TaBtDIOB; ZTBC;
ecin: BBOHUB: LIT BE i KIDBKIS;
CIBIKtQK; CISEBEHOn; H5ABT; BVSCLES;
PIBCSB»S: SPIES*; LDVGS; ACBTI;
StTlIS: COIPJBiTIVS B7iL0JT30BS; S2X;
fOBIBSIC BECICI8E
a) Bales
t) feaales

Proa a groop of 61 aatopsies.
totensic aedlcal ezailnationa. Japan,
Bales, man age 40.fi yr. peasles.
aean a4« 37.4 yr.

191CE ELEMBIS; tOTOPStBS: JaPaB:
UOBTII1B; 1BSEHIC: CaDBIQBi COSUTi
ctDOHIOK; COPPBB: IEO»; BEBCIJBT;
IICIDH; 1»aS!5IOB; BaSGiBSSB;
ROBIDI3!l! tKIKOBT: SC4SDIOI":
StlEBlni; TJTHIII01; Ta»DtOB; ZtBC;
GC1I: 3BOHIBI: LIVEH; KIOBITS;
CIBEBBTS: CZBBBEUOR: HElBlt BDSCLSS;
eilCBBaS; SPIEB8; lUDlSS; JOBtl!
R'TllS; C01E»B»TI»! E»»ld«TIOSS: SSI;
fCBHSIC BEEICIBR
8EKBESCB
_
Jenkins. B.B.
1979
«Sl-600/»-79-Oll9, 18»
PP-

















Taka«a, fl.
Soiuki-taaaaoto, H.
Amanov K.
Terai, B.
1980
Archives of
In*iioni«ntal Health
35(1)i36-«a











Takaiia, H.
Sniakl-Iasumoto. n.
Itano. K.
Terai, B.
1940
archives of
?n>itonaental H«altn
35<1).-36-«a











                                                                                       (BBXT PJGB)
-------
Ittiiony
1MO-36-0
-------
IrtlaoiT
•JMO-36-fl
SI
lt« 121.75.  H  830 C. B? I63S  C.  »P 1 M 89 *t  886 C.  10 •• Eg at 960
                                                                                         (CORIIttED)































lissas



3562
Hn.,



















3563
Long















1
EIPOSOBE BOUTE










































1
1

1
1
1
I 356*
1 Riscle
4 1
f 1
1 1






























|
t









|
|













|
1
1



1IUTTXC1L
HETHOD


U




















n






•QMS*.
or cisis


a) 3
M 2



















a) 9
b) 13
c) 23




«
















M a) 5


















b) *


































I1IOE



a) 0.22-0.52 ag/g («et
•t)
b) tot giT«n


















a) 0.011-S.067 iig/g
b) 0.033-0.58 ag/g
c) 0.023-2. « ag/g
Vet *t



SIJI | GEIIUL IBFOSRHIOl
1
1
1
a) 0.33 * or - 0.17 | I) Sales
ng/g (*et it) | t) Paaalaa
b) 0.28 * or - O.ao |
>9/9 (*«t >t) j Proa a groip of *1 antepaiec.
I foienatc aedlcal exialnatiooa, Japaa
j t*l*m, aeaa aae 40.6 jr. Fcaalea,
I lean aga 37. • 7r.
1
| IF 1C! ElEHIItS: 1 CITOPS IBS; J1PK;
I I10III8R: 1BSZIIC; CIDBIOR; CO Bill;
| CRBORIVK: COPPEE; I BOB; HEJCDBI:
| IIDItH; glGIISIII; R1IG1VE5E;
| BDBIOIIB; IIIIBOIT: SC1IDIOB;
| SILIIMS: TH1EIBB; T1R19IDR: IIITC:
| C3CIB; SBOalBZ; UTEB; KIOBEIS;
| CIBIBBOU; CZBEBEUIB: BI1BI; I1TSCLES;
| IHCBEISi SHEER: LUISS; 1OSII;
| BITHS; COUPMiTIT! EHIB1TICITS; SEI;
| PCBIISIC BIOICIRE
1
1
M 0.029 B9/J | a) Controls
b) 0. 27 ag/g | b) Vorfcer qcoap I
c) 0.32 ag/g 1 c) lorker qreip II
fet vt I
Medians | Ecceaaed r«fiaerr and saelter
| vorkers, ages 55-76 jr, exposed to
1 >«a*T Mtals 1-3 iecadas. Tiae
1 tctncn zetlreieat and Aeatli 0-1.5 fr
I Centrals, ages 43-72 jt, »ao lived SO
I ka froa t&e factory. Svedea.
1
| SIEDEI; ClBl'ESS; KINETS: LITER:
| ICIGS; COBPaBaTirS ITllVAIIOIS:
| IICOSTSIll RIGIEBE; SEaSBBERERT
| ItTBODS; SITIKOJI; 1BSBBIC; CSDBItJB;
I | CISIDR; CEIOBIDR; COB1LT; COPPEE;
| | 60IE; IBOI; UBTHlIiri; LIU;
1 | B1BS1BESI: SnCOBT; BOLYSDEIOg;
I | EBOSPBOSBS: 8V9IDI«R: SC» IDIOT;
I [ 2HEIX1M; SIITEl; TIB: TOBGSIEI;
I | HIC; SMITE R1ZMOS: HDOSTBIll
1 | Enrrs; SBEITEBS; TiLinaitu
r i
1
a) lot gir«n a) 0.01 * or - 0.01 1 at Bales
bj Rot glf«t tg/g (w«t vt) | t) Faailas
b) 0.02 + or - 0.02 I
"3/9 C*et vt) 1 Ftoi a qrcuF of 61 aatopsiea.
1 fcienslc a«Ucal •zaainatiaiw. Japaa.
I S«l«s, Man ag» «0. S rr. Tcaales,
I aaaa aga 37.4 yr.
I HtCE ELIRERIS; 10TOPSIBS; JIP1I;
I itiBini; usEiic; cjsHioa: cosiiT;
| CEEC9II4; COPPBBJ 1801; HBtCOBI;
1 iinaa: aiGiisitjB; uicansE;
1 lOEltm; iiiiROH: scuDioa:
I KlIBCTBi TIIHIDE; TUlDlna; IIVC;
I CC1B; MOBIBE: ill ft; KIOIETS;
| CII!Bt"«.: CltEBEU-OH; BE11I; 809CIES:
I tttctMS: SPtlBI; IOIGS; lOBTl;
I RITUS; COIPUlTIf! ITILUITICHS; SIX;
I fCICISIC RIIICIIE
1-
BZFTBEVCE



lakava, R.
Sazafci-Tasvaoto, H.
ftaano« K.
Tcrai. 1.
1980
accaircf of
EaTlronaeotal aealtk
J5(1):36-«













Braaeff D.
lordberg, G.
Matet, P.O.
1980
Science of tie Total
EDTlronaent 16:13-35


















Tnkava* B.
Sazaki-Iasaaoto, S.
laaaOf K.
Tecai, B.
1990
lrcfclr«s of
ZBTlroiiB«Btal Baaltb
3 (1):3«-4«













































tsJ
to
































(itrt tiGE)
-------
HtO-36-0
itl 121.75, » (30 C. BP 1«3S C, TP 1 aa 89 at «8< C,  10  u  Bg  at 960
                                                                                      (COITIUBD)
man

35«
•aieteaa

















3566
Spleea
















ZirOSVH BOOTB






































lUlITXCal
BZTICD
II


















11

















•man
OF CUES
a) C
b) 3

















aj 9
b) 3
















sues

a) lot give*
b) lot given

















a) lot give*
b) lot give*
















BE1I

a) 0.01 * or - 0.02
ag/g (vet vt)
b) 0.01 » or - 0.01
ag/g (vat vt)















a) 0.03 » or - 0.08
ag/g (vet vt)
b) 0.01 « or - 0.01
ag/g (vet vt)














etltUL XBTOIB1TXOI

a) lalaa
t) reaalea

ftoa a groan ol 61 aotopaiea.
forensic nodical ezaainatioaa, Japan.
Rales, aeaa aga ao.e jr. Taaalaa.
aaaa age 37.1 vr.

IBICI E1EBEB1S: aOTOPSISS; J1P1I;
•maim: iBsiiic; CISBXVB; COBU.T;
cBiosiua; COPIIB; 1101; BIBCDBI:
1ICCTI; BlGIESinB; BlieillSS:
toEiDiia: iniBOR; SCIIDIOM;
snmii; Tiiiiioi; wiiDioa: ziic;
601D: BBOBIBS: 1ITIB; KIDI1TS;
CIBIBS55; CIBEBCUOB; B11B1; BOSO.BS;
EIBC1I1S; SPlEllj LOBSS; ICBTi;
BITltS; COBPUITITI ITlLVmOIS; SEX:
FCBliSIC BlOICin
a) Bales
t) rcaalaa

fcoa a group of (1 aatopaiea.
focaasie aaalcal ezaaiaatioaa, Japan.
Bales, *eaa aga ao.6 re. Faaalea,
acaa age 37.* TE.
1B1CB ILBBIBU: 1CTOP3IES: J»1B:
ItSIIVIl; IBSIIIC: ClDBtOI; COBUT;
CIIOBIVR: CCEPE1; I BOB; SEBCUBT;
XIDIOB; B16IZSXVB; B1I61IISE;
BVBIDIIffl; 1BIIHOBT; SC1BDZOB;
SILBII1!; TITIBIOI: TlUOIOBi IMC;
eciB; iBOBXit; IITEB.- siniirs:
ciinivi: CMDEILOB: IEIII; HBSCIBS;
piicins; sttni; itiiesi IOBTI;
•ITILS; COBMB1TIVE ETILOITIOIS ; SEX;
ICIBISIC BZEICXBI
BBIEtEICB

Tnkava, I.
Suaki-Yasuoto, R.
laano. K.
Terai. B.
1980
Irchivea of
Environmental Health
35(1):3«-«a











Takava, B.
Suzaki-TasuBOto. B.
aaaao, K.
Terai, a.
1980
Irehivea of
Enrlroaaental Health
35(1):3«-aa










                                                                                                                                                                                             U)
-------
   ixeclor 1260
   11096-82-5
   IUCT rosaou OIKIOII OB aiDCTiiaxi»
ussoe
3567
Blood.
nbola

















1
1
1
1
I
ElfOSUBE MOT


















1
t
1
1
1
1
immcii
RBTBOD
CC-EC






















1
IOHBI8
OF C1SBS
a) 36
bj «



















1
1
1
1
SHOE
a) lot applicable
b) lot detected























I IEII
a) 8 ng/g
D) lot detected























GtllBlI. IirOSBmTIOl
>1 1019 Ca»l residents, 1 positire
sinple
B) volunteers
Bean of positive siiplss. Llnlt of
•casareient, 4.4 «g/g
Claselr latched, slnltaneous control
tuples «er« not provided foe
analysis along with those fros the 36
love Canal area residents saipled.
licking leaaingfnl control ot
literature data relative to tie
significance of the lav residues
faand la th« field saiples analyzed.
BO definite conclusions can l« dravn
fro* toe results reported.
lesideits of lew rork. controls.
eiploree* of the Enrironaantal
Protection Igencr anS aiirersity
ttidenta, north Carolina.
Ill 10 K: IOITH CISCtlll! BLOOD;
KaSntraZII BET BOOS; CUlOSItl OKUZC
tcttatns; CHLOBOBiiziiiS;
HflCnOICEEREir; POlICBLOBIHilED
EICBHTIS; POPU11TIOJ EIPOSVII

imsEicz
Bristol, O.I.
1980
EM-MO/1 -90-036, »0
pp.





















Irsenic
TMO-38-2
1C
«tl 74.921«, » 817 c at 28 atn, BP «13 c (Biblines),  TF  1 nn Eg at 380 c.  10 nn  Bg at MO C
N5
1 TISSUE
1
1
1
I j«e
1 tort*
1
1
1
f
1
1










Mood









I EIPOSBBK BOOT
1
1
1
1
1
1
1
1
1
1





















: i iinniciL
1 StTtm


ri




I
I
I
I









Coloriietrr









I IOSBSS
1 Of USES
I
1
1 2
1
















1









B1BSI



•oge detected

|
1














lot applicable








(IBtl
Bill | Gllllal IIFOBBaTICI
I

|
•one detected | Bales
1
I Tros a gro«p of tt autopsies.
1 forensic sedlcal exasinatioss, Japan.
j Hales, sean age 40.6 yr. resales.
f seas age 37.4 rr.
1
| It ICt cllRIItS; IROFSRS; JIPII;
I lIOBIfM; 1F5ZIZC; C1DJHTB; COBILT;
1 cnonra; COPPEP; 1101; BEBCOST;
1 I IBIS!; giciisna: KaieuzsE:
1 loeiBra; union; scinioi;
f SE1EIIVB: TIIUIOB; nUDIBB; Zinc:
I SCID; Bionit; LITEB; EIDIEIS;
| CIIEBB91: CIHBEIUB; BEIBT; SDSCIES;
| tllCIEaS; SF1EEI; L»CS; 1C«TI;
I amis; CO»FIHTITE ETiioitieis: SEX;
I ICHIStC IttlCIlE
1
1.3 ag/g ( Ceath liTolvisg as. Tiss« speclseos
1 lilt ted 10 SCH casat by prior
1 astoeties.
I
1 ICITB cuotiii: IHTOKI-S: ctBujts:
I errii FOISOIIIG; BLOOD; BOIESJ BBIII;
1 Bill; UTtt; msctBSt sni; »aILS;
I BtimSSltt lETBOSS; BR1LS; TOlEtSlC
\ ciitcm
1

BETEBEBCE



Tekana. B.
Saz«kl-Tass,soto, B.
Isaio, It.
Terai, s.
1980
Ircnires of
En*ixonsental Bealth
35|1):)6-*4










BcBay, l.J.
Bldsoi, B.P.
BolitKj, V.S.
1979
Jonrittl oC Inalrtlcal
Toxicology 3:222-223





-------
•rseilc
7MO-3I-2
If
lt» 74.9216,
             Bt 817 C «t 28 ats. H- 613 C  (sebUMs).  TP 1 aa B« at 380 C, 10 is 89 »t ««0 C
                                                                                       (COR»HED)
«SSOI

3570
BOM









3S71
Brala


















3ST2
trail









3573
••it

















meson Mtni






























































iiunxcai
BIT 10t
Color! aetry










I*



















Coloriaetry





























•mm
or cms
5






























2





























BUGS

0.1-2.0 ug/g










a) lone detected
b) so»e detected
c) BOM detected
d) < or - 1.3 119/9 (net
«t)















1.0-2.0 ag/g





























mi

1.3 ag/g










a) lone detected
b) lace detected
c) Rone detected
4) 0.31 » or - 0.5»
«g/« t««t »t)















1.S ag/g





























GEIIUt IIFOBIaTXOI

teatks iavoliing as. lorsals. 0.1
tad 0.2* toy? (secondary raferaace) .
Tii»< specinns Halted in soie
cam by prior autopsies.

11 eikvaed tcdlea baried 2 «k-91 jr.
ICITB cHoiin; tno?siss: CIDITEIS;
eiTlt NISOIIRG; BLOOD; BOISS; EE1I»;
mi; Litrn; TOSCLE3; »ILS: SKU:
iiisvinni BIT BODS: IRILS; FOBEISIC
(IBKIII
a) Hales* cerebral* 13 subjects
k) Vesales, cerebrva, 5 sabjects
c> Rales, cerebellne. 11 aabjects
d) feiales. cerebell.ua. T labjects

fcoa a vcoap of 61 autopsies.
forensic aedical ezaaiBatioas, Japan.
Hales, aeaa aae 40.6 yr. resales.
M«B aqe 37.* yr.
tBICt ILBHtlTS; 1BTOP3IIS; J»P11;
lIOHIin; 1BSEIIC; C1DBIOB; COB1LT:
CBlCHIOl: COPPBE; IBOl; BESCOBT;
IBCIDB: aiGiisiua: IMGHISE:
tiEiDioK: iniROBi: SCMDXDH:
SUKim: TITUIDR; 7HIDIOB; ZIHC;
GCID; BBOBIII; 1ITE1; KIDIETS;
CIBBBBOl; CEBEBEtlOB; BUST; HO SCI. IS:
E1ICRE1S; SntXt; IDIOS; ICBTl;
BITIIS; CO'PIBiTITZ ETlLDiTIOIS; SEX;
KlflSIC BEDICXBE
faaths larolvinq Is. Tissue
iieelsens llaited Is aoae cases by
prior aatopsies.

11 eihased bodies bocied 2 ttk-97 TC.

BCPTI citoiiBi: imopsus: CIDMEBS;
DITIL POISOIIISi BLCOD; BOIES; EB1II;
BUB: llfEB; HOSCIES; SKI I; MIIS;
BB1SOBS1SI1 BETBODS; 1ET11S; FOBSISIC
BtCICII!
ftviev. 2» repreoeitatiTC
Fce-asalTsis treataeats ace
tabelatel. Ihe feasibilitf of a
kclistlc, no-«asli policy for hale
analysis Is eatlised and supported.
BEVIE*; TBtCE I1IIERS; Bill;
IBSTSUII; BElSHBElin SETBODS;
tfllLS; PBOTIIMS; COSPiBlTITI
itiinTiois; iineiioB: HTXHOII:
1ISEBXC; BUIDB; BSOSIBE; C1DBIIB:
cucioii: CBICBXIE; CBROHXOH: COEILI;
CCPPIB; 61ILIOB; GEBBinOHs GOLD;
ICDI1E; IBOl; LlaTBllVB: IE1D;
iieiEsiOR; iiieiiESE; sracnsT;
CCmDEIOH; HCKEL; IBOSPBOBDS;
toiissius; BOBiaiati; SELEIXIH;
SIHCOI: SII1EB; SODXOB; STBCITIDB;
SOLPOB: Til; TXltlXDtl; TOI6S1EI;
IIIC: TIBCOIIOB
BIfllEICE

HcBay, I.J.
Badsoo. S.P.
Baling, T.8.
1979
Jaarnel of analytical
Toxicology 3:222-223





Tukava. fi.
suznki-Tasaaoto. a.
&aano. K.
Terai. H.
1990
IrchiTes of
EnTiconsental Bealth
35(1): 36-4*












IcBay, l.J.
Radso*. H.P.
Boliag, T.B.
1979
Journal of Analytical
Toxicology 3:222-223





Cbittlebocosgh. G.
1980
Science of the Total
Eniiroasent U: 53-75















                                                                                       (HIT PtSZ)
-------
IM0-38-2
if
lt» 7*.921C. IT 817 c at 28 atm, BP *13 C (aabllaea). « 1 » Ig «t 380 C. 10 aa Si *t («0 c


HSSBI
3S7»
«»ir
3575
I«lc
ixposms wot

laatttiox
laaalatioa
1
1
3:16
Stir
amnmi
1ZTBOD
ColoriMtrr
u
r
•VMB>
or cisas
3
*
1
1
Mies
a) lot applicable
1) tot applicable
e) lot applicable
A) lot applicable
•) lot applicable
a) 10.8-76.1 ppa
b) 8,26-11.7 pp>
c) 3.33-K.O J>P«
t) 8.6-63.1 ppa
•) 4.22-12.7 ppa
f) 5.61-38.5 ppa

mi i sunn itrciBitioi i BsreiCTCj
1 1
1 1
1 1
a) C.O 119/4 1 •> <*•* •• ««tr 1 BcSay. l.J.
b) 9.0 «j/« 1 M «*•» 2' »e«lp aalr 1 Hodaon, 8.F.
c) 2T «g/g I c> Caw t, »calp aalr - proilaal I soling. T.S.
tj 10 «j/j I J) CIM 3, acalp balr - U«tal | 197*
«| IS «j/7 I «) Can 3, >aal« 1 Jaanal ot analrtleal
| tmtas livalTtnq >«, T!MM t Taxlcologi 3:222-223
1 *;«eiMm* liilt«4 la IOM caaa* bi 1
1 prior aitocila*. »
1 11 «a«a*d tedl«« 6«ri«d 2 «k-»7 re. 1
i tens citoim; tnorsitss cunmss i
I ittu raisoine; HOOD: BOIISJ BSU»: i
1 Bill: lilts; susciIS; sell: mis; 1
I iiastniHSit iRioas; BETU.S: roiasic i
i ncicni i
i t
1 1
a) lot siren I a) rtoa acaa, steel bconz« >crk«n I claf. J.S.
b) lot gi»«a j tl fcei lead, otMr norkcrs it I sale, I.
cl lot glTea | factory 1 cross, J. p.
dj (at girea 1 c| rrm a«ad, «te»l tcoaie rcrlters at I 1977
e) Hot flT«a 1 ctfcct factories I Journal of tbe SocietT
f) Rot oiren | if mm patlc area, steal broaia 1 of Occupational
I >ctk*r> I MdlclB* 27:102-104
1 <) tmm pabic am. otaar «orkets at I
I tactoiT |
1 f) froa pabic acea, steal brcne 1
I wcikeri at other factories f
1 I
1 letters ID factory ihere arilae 1
f faetorlea, U.K. I
I iiiizd meaci: umrs; MT*I i
r ICIJOiriS; BllB; »I13; CORM9IHTE I
I IH1B1TI01S; IimiSTim HTClni; I
1 iisnic: cisi; HULTB nziBDs: i
| IHIDSItlH IIROSPEEIBS |
i r
t 1
I t r«»iei of «orld literatare ot tie I Jenkitt, D. ».
1 accanlatloa an* blooonceatratiaji of I 1979
I selected toclc tcacw »
-------
Iticiie
1MO-38-2
II
Itl 7«.921C. HP 817 c at 28 »t», BP 613 C (sabliaes). TP 1 •• Eg at 380 C.  10 ••  Rg at MO c
                                                                                      (COItliaSD)
1ISSBI

JS77
Mart

















3578
Md»«T

















3579
Iido«T




















iipososs BOUTS




























































aEURICal
HIT BOB
11

















11


















11





















itmen
or casss
a) 10
b) S

















a| 23
b| 3

















at 8
b> 9
cl 9



















UBSS

a) < Or • 1.* «g/g (««t
•*)
b) BOM detected
















a) < or - 1.7 eg/g (Mt
*t)
b) < or « 1.« ag/g (»et
rt)















a) 0.0030-0.01* ag/g
b) 0.0020-0.016 ig/g
c) 0.0020-0.052 ag/g
I«t vt


















mil

a) 0.1* * or - 0.«»
»g/g (««t rt|
b) Bone detected
















a) 0.1* * or - 0.43
ag/g («et »t)
b) 0.»7 t or - 0.81
ag/» <»et »t)















a) 0.00*0 ag/g
b) 0.0095 ag/g
e) 0.0038 ag/g
let «t
leiiaas

















esisui IIPOBIMIOI

a) lales
t) Faialvi

ttoa a groap of Cl aatopziaa.
Coranatc aedlcal exaaiaatioast Japa*.
I<1<«, aetn ag« *0.< IT. F«ul«s.
•cai aga 37.* jc.

nici miens: aoropsiss; JIPII:
itmiioR: iissiic; ciosioa; COBU.T;
ceioiim: CCPPSBI 1101 : RSICOIT;
iirxvi: 816IISIOR: BUGIIISI:
SD3IBIUJ; llHBOiT; SCllDlnB;
snsiiiH; UTiMioB; vinoioR: me:
GC1D; BBOBIII: UTEB; SIDIZIS;
CIBIBinS; ClBEBSUORi HS1BI; HUSCLSS;
limns: sptEE«: miss; IOBTI:
IIT1LS; COSJ1BHITE ETIIDITIOIS; SEX;
fCSHSIC BIOICIHS
•) Ralas
t) T«l«l«s

Troa a group of Cl aatopsies.
fcr*nalc medical •xaainatioos, Japan.
Balas, a«aa ag« »0. 6 yr. ?aaal«s.
iaaa age 37.* jt.

met nsBsns: aotopsisss JIPII;
iiinin: USCTICJ CIDHIDB; coaiu;
ctBOBim: coppiB: xioi; Hiicnsi:
IB tins j siciisiUB; nieiisss:
BdsiDiiia: iBiiROii: sciiDins:
SItSBI0H; TIIMTOB; T1MDXDR: IIIC;
6010; B10HIII; LITBB; HOISTS;
CIBtBBOI: CIBEBBUaH; HS1BT; IVSdBS:
fltCBElS: SPISII; IDBSS: 1CBT1:
IITILS; COBP1B1T1TI ETltOltlCIS; SIX;
ICIIBSIC iinciii
i) Costrolt
k) war liar qroap I
c) lortar gteap II

Caceaaei cafinery aad saelter
vcckars* ag«> 55—76 jcf expoaed to
taaTf aatala 1-3 decaaes. Tiae
betMea retiieaent anl death 0-1. S yr
ia graap I an! 2-19 It, qioaf II.
ceatrols, ages *3-72 yr, iko llni SO
ka froa tb« factory. Sweden.
SBCCIB; CIOITSBS; KIDBETS; IITSB:
UlSSi CORPliHItl 1T1101TIOBS:
IIDCSTH11 II6ISIS; RSISOSERIBT
SIIBODS: 1BTIBOII; IBSEBIC; C1DBIOB;
ClStdl: CBBCHIOR: COEltT; COPPBB:
COLD: IBOB; X1I1R1IOB: IBID;
B1B61BUI: SIBCUBT: HOITBDZBOB;
iiospioivs: BOBiDiua; SCIIDIOS:
EILZBIDB; SXIYiBi TIBj laBGSTSI;
tnc; HSttTl UZ1BDS; IIBBSTBIll
EIIITS; SREIIEBS: TStmiOl
ESnUBCS

lakava. H.
Saiaki-Tacaeoto, R.
taano, K.
Teral. R.
1*80
Irehives of
EBTlrooaentsl Health
35(1):36-«»











Yakava. H-
Soiakl-Iasaaoto. R.
laano. E.
Terai, B.
1*80
arcaivea of
BDTiroiaectal Healtk
35(1|:3<-*«











Brana, D.
Vordberg* 6.
Mater, P.O.
mo
Science of the Total
CnTlronaaat 16:13-35

















-------
manic
74*0-18-2
a*
att T*.921C. «P 8IT C at 28  ata, » 613 C (artliaex) . TP  1 aa  If *t  380 c,  10 » B« «t **« C
                                                                                       (CORIIITED)

IISSffB
3560
LlMr
3!»f
Ilmt
BZF031BI SOWS

1
immClL
IRBOD
(1
11
(
1
1 3S82 f Colorlaetrr
1 U»er 1
( I
i r
101 em
or ctse
«> IS
b| 8
t| 8
b) 9
c) 10
8
t
1
BMOE U1I 1 EIKU1 IirtJtBlTIOB I SttttXICt
1 1
a> < or - 3.3 ag/g (mt al «. » + or - 0.»S I •) Bal« I Takava, 8.
rt) aa/» (vet «t| 1 It ?«••!•» t S»«W.-raanaota, 9.
») COM tetceted b) ROM *etect«d I 1 *nao. !.
1 rcoi i Troap at SI Mtapai**, I T«r»i, 1.
1 fomdc Mileal «x**ln«tioBs> Japan. I HBO
1 Bil«i, •••• aq« «0.6 rr. r«al», 1 irchires of
1 nu *v> 3^'* rr- 1 ZDTlcg»eBtal Jtalth
1 ( 35<1)i3«-«»
I «ICE taettrs; tmotsitst jwti; i
J liealOTI; IISHIC; CIDnVI; COSU.T: 1
i cnonoi: oo>m: IBO»S BSKOEI: i
I i»iva; sioMsitja; BUGIIBSI; i
i tviigiim: I«TUO»T; sctmim; i
I sniim: Timrtw; nuozvi; z»c: i
I sen; Btoaiii; IITEB; KIOIETS; i
i ciiuan: cnnriLOB; IBUT: SOSO.BS: (
1 Micsus! SPIHI; IDKJS: tont: I
I srms: coapiiinn iruomoTS; six: i
| KinSIC VEDICtK 1
> i
*> 0.0019-0.013 •«/«
fe| t.0030-C.(»J >g/4
C) 0.0020-0.0050 04/9
let lit
2-SS ig/a
1 1
a) 0.0030 09/9 1 «l co.troJs r Sraa*. 0.
b) 0.0085 ay/g r t) larkec fccan I 1 tortbarg, 6.
c) 0.0**0 «j/g | c) forkar grcop II 1 lestM, S.O.
rat «t I 1 W80
Hediaiu f X«c«as«d r«£in*ry and *a«lt«c I Science of tfce fotal
| «ort«n, a««* 55-76 fr, aipoced to 1 tn¥lcoo«ent 16:13-35
I «g«x 1J-7J TC, iia llnd SO (
I ti fcea tie laetarr. Svaaen. 1
1 1
1 5«lt!«; cm»E8S; KioiRSi lirfs: I
1 tnes: COBPISKITI miuiiois; i
| IJMSTBIU BIGIHB; B!lSti!Bt»T I
f HttOOS; IRUOir; USZVIC; ODHBB; I
cisiai: cBBoeidd; COULT: COPPH.- I
coit; iso«: unBHns: uio: i
FJIGIIISB: mean; BotiBDUm: i
taaspvnvs; BOSIDWB: sciinra; i
smiiaii; sitfre: TI»: Ttrissrjs; I
ZIIC; g»HB BaZIEOS; IHDttStEIll |
TllltS; SRItTEBS; 1XUQHV8 1
1
13.6 09/9 tcath* i»»ol»ioq it. taimtlt, 0. OS 1 BcBay, l.o.
aid 0.2* 04/4 (aecoataiT referance). I Badaoa, P.P.
Ilane speclaeaa Uaitel la soie 1 Bolinq, r.B.
c»e* br prlcr aatoasiea. 1 1979
1 Joicnal of mlrttcil
It eskaaad bcdiea bortel 2 rt-*7 rt. 1 Toxlcoloar 3:222-223
t
ICBia CIIOITU; 10TOPSIIS; C101TKS; I
sun POISOIIK3: aiooi; BO»S; miij i
Bill: UTtE; BUSC1ES; »»HS; sri>; 1
•tisninn IRBOKS: SHT*I.S: rosusrc i
ttnatt i
i
(KIT PIGI)
                                                                                                                                                                                           os
-------
linilc
7MO-38-2
II
»t» 7I.921C.
             BP 817  C at 28 ata.  tt  613 c  (snMiMS).  TP 1  •• 84 at  380  C,  10  a* Hg  at  atg  c
                                                                                     (COITHDBD)
1ISSTJE

3583
lung















358*
Ing




















3585
Raacle

















EIPOSOBB S001I



























































luinictt
BXTBOD
It
















Ik





















U


















IHBESS
OF CASES
a) 5
b) »















a) 9
b) 13
0 22



















a) 5
b) 10

















URGE

a) < or • 5.3 99/9 (wet
*t)
b) < or » 0.5* ag/g (wet
•t)













a) 0.0010-0.018 ag/g
b) 0.023-0.013 ng/g
c) 0.01»-0.21 ag/g
let "t


















a) < or » 0.50 ag/g (wet
"t)
b) < or * 0.85 ag/g (net
Wt)















Bill

a) 1.3 * or - 2.3
ug/g (wet wt)
b) 0. 1« » or - 0.27
ug/g (vet lit)













a) 0.0080 ag/g
b) 0,013 ag/g
c) 0.0*8 ag/g
Set *t
Bella as

















a) 0.10 « or - 0.22
ag/g (wet wt)
b) 0.09 « or - 0.27
vg/g (vet vt)















etIZBlI. IIFOXB1TIC1

a) Rales
I) Feaales

It am a groap of 61 aatapsles.
forensic nedieal examinations. Japan.
Bales, aean age «0.6 yr. Feaales,
aean age 37. a yr.
IB1CZ ZIZBI1TS: HJTOPSIBS; J1P1I;
noiiim: iBszvic: ctsaioa; COBH.T:
CHORUM; COfPSB.: IBO«; BEBCOBT;
IICIUB; BlGHlSIHB; RafGkBlSE;
IIIIIXDR; JITIBOIT; SCSIDIOB;
GCIO: BKORIIZ: IITZ8: KlfilZtS;
CIBZEKD!!; ClfEBZUOB: HE1BI; RDSCLBS:
fllCBZAS; SPlEZ-Ij 1QBGS; AGBTk;
BIT11S; COBP»B>TITS ZTUD1TIOI5; SBX;
ICBIISIC R1CICIIZ
«) Controls
t) Vorker gccqp I
c) Vorker grcnp IX

leceasai refinery and snelter
•crkers, ages 55-76 yr, exposes to
teavy aetals 1-3 decades. Tine
tctmea retireaent and death 0-1.5 yr
It group I and 2-19 yr, group II.
Ccntrols, ages 13-72 yr. vho lited 50
ka froa the factory. Sweden.
StZDZl; C1E1TZBS; KXDIZTS; 1ITEB;
imest coapiBiTiT! zTiigiiiois;
XlCISnill. BTGIEIE: BE1SDB1BUT
iHHons; imsovi; iismc: cmaioi;
cisnm; c HBO sio a ; CCBIIT; COPPII;
COII; IROI; HHIBIIOB; LEU;
E1161KS1: BtECOBY; B01TBDIIOB;
tlOSPBOBdSi BOBIBinB; SCUDIOT:
SKZIIM: SIITIP. ; ?II; TBiGSltM;
IHC: BZtlTB B1Z1SBS: IHIOSTBIil
PltHTS; SBZITEBS; TILLnBlOR
» Bales
t) resales

Iroa a groap of 61 autopsies.
forensic nedical exaalnations, Japan.
Bales, nean age «0.6 yr. Fcaales,
aean age 37. (1 yr.

isict SLHiiiS; inTO?sizs: JIPSI;
iicBi»oa: iKszmc; UDBIDB: COBU.T:
CBIOBiail; CCPPXB; IBOI; RZBCtBT;
IICIOR: »«isx0fl: BIIGIBZSZ:
BDBIBMl; 1IIIBOK; SCiUBIDB;
sttzixtii; TIUIIDR: TiiiDioa: znc;
GCID; B30BIII; IITIB; KIDSSTS;
CIBEBR31; C1EEBEXLOB; BJiBI; BOSC1BS;
PlICKIS; SPIZZI; LDBGS; 10B11;
BIT«LS: C09P1MTITZ BTlLDtllCBS: SEX;
fCIZISIC BECICI"!
BZFEBEBC5

Takava. H.
Saznki-Iasaioto, a.
leano* K.
Terai. 9.
1*80
archives of
iBTiconnental Bealth
( ): »«









Brane, D.
•ordberg. G.
•ester, P.O.
1980
Science of the Total
Environaeat 16:13-35
















Yakava, n.
SvznU-Tasaaoto, a.
laano, 1C.
Terai, S.
1930
irchires of
XnTlronnental Health
35(1):36-«»











(KIT PIG!)
                                                                                                                                                                                          IS3
                                                                                                                                                                                          VD
-------
Itsenic
m0-38-2
Ai
Its 71.9216. IP BIT C at 28 at.. BP  613 C (sublines).  TP 1 an Bg at 380 c, 10 •• 89 at 440 C
                                                                                       (C01TIIDBD)
TISSUE

3586
Bnscle












3587
Hall















3588
Bail




















BXPO30BE BO01B















Ingestlon
Inhalation





































ABA1TTXCAL
8ETBOD
Colociaetry













u





































BUBBBB
OF CASES
5













9





































BAHGE

0.8-5-0 ug/g













a) 15.0-188.0 ppi
b) 0.97-6.00 ppn
c) 6.45-53.3 ppn
d) 10.8-60.9 ppn
e) 2.98-4.81 ppa
f) 1.06-5.79 ppn

































(BEIT
BBaB

3. a ng/g













a) Bat given
b) Bat given
c) Hot given
d) Bot given
e) Bot given
fl Bot given






























•


PASE)
GEBIBAl IHFOBBATIOB

Eeaths Involving Is. Bornal, 0.43
ug/g (secondary xefeieDce) . tissue
steclseas United in sone eases by
prior aotopsles.

11 eihued bodies burled 2 «k-»7 vr.
Case adnitted to eaergency roon «itb
gastritis died 1 day later after
x«eoning cyatotic and Incoherent.
ICBTR C1BOUBA; IIROPSIBS; C1D»¥EBS;
BITU POISOIIB6; B100D; BOBBS; EE»IB;
BIIB; iiTEB; aoscus; SRTB; i»ns;
mSOBESBST BBTHOOS; RBTA1S; T01EBSIC
BIDICH?
_
a) Fron linq«rs, steel bronze workers
fc) Icon fingers* otber workers at
factory
c) Fron lingers, steel bronse norkers
at other factories
1) Fron toes, steel bronze workers
e) fron toes, other workers at
factory
f) Fron toes, steel bronze vcrkers at
ether factories
Icrkers in factory where arslne
poisoning occurred and in other area
factories, O.K.
OBI1ED KIHGOCB; ADULTS; BBI1I
fOlSOBIBC; BUB; B1I1S; COBPtBlTIVE
IltltUTIOBS; IHDOSTBU1 HIGIIBB;
IBSZHIC; COST; BUITR B1ZABDS;
IIDOSTBIil limSPRBBES
.
1 review of world literature on the
accnnolation and bioconcentcatian of
selected toxic trace netals in ho wan
hair and nails and other nannalian
hair, far, nails, claws and hoofs.
latnlated ty geographic area.
subjects, sei. age, exposure
gradient, analyses in ppn. and
authority frcn over 100 references.
JFSICM IOSTBU.I1: ClBADl; CEHTI1L
IB1BICS; IOBOP8; KIDDIE EAST; BBS
1I1IABD; SOOTH ABEBICA; 500TBEAST
1SIA; OHJTED ICIHBDOB; OH IT ED ST1TSS;
BIIB: BAILS; BETIEW; ABTIBOBy;
IFSEBIC; EOBCB; CADIIDfl; CBBCBIOB;
CCBALT: COPPIB: IEAD; BSBCOBI;
BICKEl; SELIBIOH; TIB; TABAOIOI); AIB
ECIIOTIOB; ABIIAl POFOLATIOBS;
EICACCnaDIATIOB; BIOISDICITOBS; LAHD
ECIIOTIOB; POPDLATIOH EIPOSOEE; B4TBP
ICIIDTIOB; TBACV 31EHEBTS; BETAIS

BEFEBEBCE

IcBay, A.J.
Badson. B.P.
Doling, V.B.
1»79
Journal of Analytical
Tozicology 3:222-223








clay. J.E.
Dale, I.
Cross. J. D.
1977
Journal of the Society
of Occupational
Redlclne 27:102-104











Jenkins. D.W.
1979
EP1-600/H-79-049, 18«
PP-


















                                                                                                                                                                                             LO
                                                                                                                                                                                             o
-------
7MO-J8-2
It
Itl 74.9214.
             IP 817 C at 28 ata. >? 613 C (sablises) , TP  1 »•  tg  at 380  c.  10 •• Bg at MO C
                                                                                      (COBTI1DED)
TISSUE

3589
tancreas

















3590
Skia









3591
Spleea

















EIPOSUBS SOOTE

















































lllLTIICll
UTBOD
n


















Coloriaetry









11


















IflaBES
or cisss
a) 8
b) *

















4









a) 10
b) 6

















SIR6B

a) < or - 1.3 ag/g (mt

b) loae detected
















0.4-1.0 ag/g









a) < or - 0.5S ag/g (vet

b) lane detected
















BE1I

a) 0.28 * or - 0.48
ag/g (*et *t)
b) lose detected
















0.66 og/g









a) 0.07 + or - 0.18

b) loae detected
















Gtlliai IIFOiaiTIOl

a) Bales
t) resales

Icoa a groap of 61 autopsies.
forensic sedical exaaiaations. Japan.
Hales* seaa age 40.6 yr. resales.
aeaa age 37.4 yr.

TBICE ZLBBEHS; aUTOPSIZS; JftPIV;
IIOBIIUB; IBSEIIC: CiDBIOB; COB1LT;
CflOBIUB: COPFBB; IBOI; HEBCOBT;
litiuB: aaeiEsiai; aiieiisss;
IltlDIVH: alTIROR: SCIIDIOB;
s ii nua; TiHiioa: Taiaoiui; zitc;
ecu; BBOBIIB; LITIB: KIDIBTS;
C1IEBBHB; CIIEBI1LOB; IUBT; BUSCLIS;
titcftEiS; SMi«»: lines; ICBTI:
IRUS; COBCUHITE ETILUHOCS; SSI;
fCIEISIC IICICIIE
Ciaths iavoltiag as. lorsal 0.59
«g/g (secondary reference) . Tissae
speciaeas liaited in sone cases by
flior antotsies.

11 exhaled bodies boded 2 «k-97 yr.
ICIta C1B01II1; 1UTOPSIES: CIDtfESS;
BlTll POISOII1G; B1000; BOIES; BB»IW;
C1IS; lira; BOSC1ES; SKIB; I1IIS;
aiisnBtim HZTIODS: anaLS; FOBEISIC
itDicias
a) Rales
t) Feaales

Iroi a qcOBf of 61 autopsies.
forensic aedical eiaaiiatieu. Japan.
Bales, nean age 40.6 yr. resales.
scan age 37.4 yr.

Tiaci niazixs; mofsns: JJPAS;
iimnna: USEIIC; cinaiaa: cosui;
CIICRIOR: CCEPEB; IB01; REBCISI;
liriOH; RIGIESIVB; ItlSaiESE;
iiBiomi: niiRoiy; scaroioB;
SZIEIID9; TIiatlOR; flUDIOB: ZIIC;
eett; Bsoaiii: IIVEB; KIBBZTS;
cisiBtan; CZIEBSUOR; IE1IT; ansciES;
EllCSttS; SflEEl: LDieS; 10BU;
BIT IIS; COBPaBlTITE IT»10«IOIS; SZI;
ZCBZSSIC BZtlCIIX
BZRBEICI

Takava, B.
sazaki-Tasaaoto. a.
inaao. S.
Terai. B.
1980
archives of
Eavironaeatal Health
3S(1):3«-4*











RcBay. a.J.
Hudson, I.;.
Boliag, T.E.
1979
Joaraal of analytical
Toxicology 3:222-223





T«ka«a. R.
Sazaki-Tasasoto, Hi
asaao. K.
Terai, a.
1980
archives of
ZiTironsental Bealth
35(1):3«-aa











                                                                                        IIEIT
-------
Irscnie
7M9-38-2
la
lt» 74.9216, HP 817 C at 28 at., BP  613  C (subliaes), TP 1 >• Bg at 380 C, 10 mm Bg at  MO C
                                                                                       (COITIIOZ9)


















IISSOI

3592
Brine













EIPOSOB! BOOH
















1
minion
OTBCD
















j

IOHBZH
OF C1SSS


















1

tuet reii etizsiL IIFOIBITIOI

a) lot glttm a) 0.8 ag/g •) 9 ratal etildne, inarganic 19
b) lot givca ereatlaina t> 1* cklldm ILiiiq < 1 ka froa
c) lot 9iT«« b) 2.2 ag/g . 2.5 ka froa aaalter.
f) 5 ag/g creatinina tetal Is
I q) 7 ag/g creatinine f) 21 riral bora, total Is
1 Mdlans 9) 22 riral girls, total Is
c)-g) estiiatatf froa graph
Seaool-aga enlldran living naar Pb
sialtar in Ealgiaa. Controls fron

IlieilftSl; C.DBI08; USIIIC; 1SSZIIC
CBS1IIC COiPCOIDS; CBI1DBBI;
iiDosmn. iisosrszsts: SRZUZBS;
tlTUS; BIOOC; ni»; B1LGIOH;
fcpuiiTio iiPosnBi: iniu isiis;
| UIE1B 1RZ1S
1 1
3593 US 1 30 a) 7«-93» ng/1 a) 3«7. 0 ag/1 I a) Iiposad icrkers, 1G-11S technique
1 Urine I 1 bj 91-9S3 og/1 b) 368.8 ug/1 t) Biposad wcrkers, ET-115 technique
| lie) «.»-23. 9 ng/1 e) U.5 09/1 e) Controls, 1G-11S technique
| | d) 6.5-42.5 ng/1 d) 18.66 ag/1 «) Controls. ET-llS technique
III e) 6.9-25.6 «g/l e) 14.73 ug/1 «) Baaitarrnnean sorters, 1G-11S
| | | f) 36-1180 og/1 f) 382.6 09/1 t€Ckniq««
I I g) 15.5-113.1 ug/1 arkars excoscd ta Is203 and S
centrols. 10 Hedit«rra»aans, 10
Klglaa, totb possiblr •zposed to
inorganic Is bat diffarant lisk
ccnsasption. Data arailabla for
velsntaars and attasptad saicidas.

EHSlm; HE HE; COSP1HTIYI
iTiiDiTiois; nismmi HEIBOOS;
IBSnlC; IBSIIIC OI61IIC COaPOOIDS;
tuts; iiDosttlu puras: IIRBU
(IT1BC1ISB

SEfEBEHCE

Backet, j.p.
Foals, B.
laawarra, B.
Braaax, P.
Claars-Tkoraaa, !.
lafontaina, 1.
Verdarn, G.
1980
Invironseatal xasaareb
22:95-108












ncket, J.P.
laanarrs, B.
eels, B.
980
ateraational Irckivas
f Occupational and
nvironsantal Haalth
6:11-29


















-------
U»lM
778»-»2-1
II-B3
Bl 77.93.  » -117 C, B* -«2.S C
TISSUE
359*
Mir











BIPOSOBZ BOVTZ
InhllltiOn












iiiLrricii
RETROD













IORBZB
or CISBS
«












11KI
•) 39-216 ppa
b) 22-107 Hi











HZ1R
a) 107.3 ppa
b) 18.3 ppl











GEBisiL iirosBancR
•) Iftar 9 flays, loot sagiant
b| >it«r 19 days. 0-1 cm Ito» root

50-51 yc old sailor*.

»«»«r, Matacsa, naasaa, toiitinq.
diarrhaa, abdoainal pain.

BfBoqlobinaria, iatravascular
haiolysls. aarroa leprcssien.
ttioibocTterania. reaal failure.
ptiipliaral utoropatky-
ustmc; BUI; occnpi-ioiii HIUBDS
SEiEincz
slUlnson. s.P.
RcHnih, P.
Borsloy, S.
Tobba. R.
le»ls, 8.
Thooli. 1.
Mnterton. H.
Parsons, V.
Vllllaas. B.
1975
British Radical Journal
3(S983):559-5«3

 Irsifta oiide,
 Irslalc acid.
 C2-B7-1S-O2
 Bl 137.99. RI 200 C
                      - (9 CI)
                               (8 CI)
1ISSU!
3595
aria*











BltOSOBS BOOT I













aiumcii
BFTBCD













IOHBZS
or cisss
a) 9
b) 1»











tlBSt
a) lot gi»«n
b) lot gi»en











SE»«
a) 9.2 ag/g
croatinine
b) 11.2 09/9
cr«atlniae









S1I!B»L mOBHlTICI
a) Bncal ehlUrea
b) chiHren near sa«lter

Sekool-aije ehildraa liTinq »«ar tts
ciclter in Belqiua. Control* froa
meal aad arban araas.

R1I6IKSZ; CIE8I05; »SmC; 1RSEHIC
GfSirtC COITCTODS: CHI19RII;
IBDDSTBItl IHOSPBSS1S; SBI1TZBS;
BITtIS: BtOOC; UBIIS; BILGIBB;
ICIOL1TIOB IITOSORB; »DS»1 1BZ1S;
DIEII 1BI1S
BirZISBCI
Bucket, J.P.
Eoels, B.
Laanrys, B.
Brnaax. t.
ciMTs-Thoraaa , r.
lafontaina, a.
Terdnrn, 6.
1980
ZnTironaeatal Research
22:95-108



                                                                                                                                                                                        UJ
                                                                                                                                                                                        u>
 1tbastos
 1332-21-t
 IIICT coiposinoi amo*B OB OBIZTZBRMZD
nssm
3596
Gastric
liqola






BIPOSOB! BOITE









HI1LTTICH
BITBOD
Bicroscopy








BVBBSB
or cisss
13








S1BGI
0-2500 ferraqluoas
todies/20 il






(BEXT
BE1B
Hot 9iTen







?1SE)
GZIIBtl IBrOBBlTIOB


33-72 rr olds nit! 1-50 yr
occapatianal axposora

ISBISTOS; OCCUPlTIOItL H.Z1FDS;
IUBSS; ISDOS1BHI 1TSOSPBZBIS; DOST;
II>BCB

lErZBEECI
Biqnon, J.
Sebasties, ?.
Bonchaoz, G.
Boanaad, G.
197*
IBSZBR 29:205-218



-------
ItbeStOS
1332-21-*
IUCT coBfosmoB nno» 01
                                                                              (COBfttDZD)


























IISSOB



3S97
Gastric
llqaid











3598
Intestlae
EXfOS«n BOOM

















lagestlos



1IUYIIC1L
BETBCD


Biereseopv













IB

I0BBEB I1ICI Bill | CHIllt IirOlBllICl
or CISBS i
i

a) 0-158/20 nl a) lot given I a) lorkers hiadllaq raw asbestos
b) 0-»/20 al b) lot given I t) lorkers aaat factoring aabestos
c) 0-3/20 si c) lot given j [rodacts
I e) lorkers exposed to sized
1 iadostrial dgsts
1
1 33-M vr olds, »ith varinos disease
| occapatioaally exposed to asbestos.
1
| JStlSTOS; OCCOP1TI011L B1Z1BOS;
1 iciss: occnpiTiont oisusis:
I 1CTOPSKS; IIDOStlllL 1TBOSFITEIIS:
1 IQSI; nilCf
1
a) 21 a) not gives a) 150.0110 (!-5) I a) Controls
b) 32 bl lot given fibers/a I b) lesidents wlta long tern, bigb
b) 1«.3i10
-------
libestos
1332-21-*
IHCT coBposmoi omoiM ct OIDITHHIKD
txssoi

3600
larynx

























3601
liver












3602
mag








3«03
HBO






n*OS01J BOOT!

Inhalation

























Ingestion




























iiunicai
BETBC8
n
licroscepy

























n












HI








Bicroscopy






BDBBEB
or cists
2

























a) 20
b) 32












1








13






fllGI

a) lot applicable
b) lot applicable

























a) let gives
b) lot given












a)
1.4x10(1*7} -3.3x10 (E»71
fibera/g
b)
2. 7x10 (E+7) -6.5x10 (E+7)
fibers/g
Dry »t




lot deternined-200,000
ferruginous bodies/en cs






Hal

a) 590 fibers/eg
b) 3600 fibers/ig
Dry vt
























a) 153. 5110 (!-5)
fibers/g
b) 32. «1 10 (1-5)
fibers/9
Ish »t









a) 2.1x10(1*7)
fibers/9
b) 3.9x10(1*7)
fibers/g
3FT Vt






Hot given






6HI11L IIPOS81TIOI

a) Patieat 1. Fiber eea> length 2.»
a, Man Planter 0.08 a. Bate
ctiT'Otile thu aiphlbole fibers, lo
femgieaoc todies
l» Patiemt 2. Fiber Bean length 3. «
i. Bean lianeter 0.1* n. Bore
aapiiaole tkan chrysotile fibers
lorsal tissue.
fatleat 1. age SI yr. Exposure
tetceen aqes 13-15 Tr in welding
factory and tetveen ages 20-10 Tr as
electric arc Holder. Patient 2,
EBoker, aqe 51 yr. HeaTy exposure in
asbestos ceaeat plaetv pre-Vorld Var
2.
EneBsoeoBiosis. bronchitis. Benign
polyp on vocal cord (Patient 1) ,
sqoasoes cell caiciaoaa of larynx
llatieet 2) .
long opacities, costopkrenic angle
obliteration, plevral »all thickened.
FIHCt; ItDITS; CIS! HISTOBI1S;
IIDOSTIIll DISBISIS; M10PLJSBS;
CCCtlflTIOIll DISE1SES;
BHD10COBIOSIS; IHISS; 1TBPB BOOZS;
Eioiccninimoi: nsras; IIBH»TIO«:
1SEISTOS
a) Controls
b) Residents «ith long tern, high
level exposare troe drinking
centeniiated «ater
Chrysotile fibers
latopsies
52-S9 yr old resideats near taconite
riocessiag plant, Binaesota. 17-77 yr
eld controls. Minnesota and Texas.
B11IZSOT1; HUS: 10TOPSIXS:
iiiiSTiiis: urn: LOIGS; DSIMKHG
IITIB; IKtlDSIBIlI SBISSIOSS;
I1DOSTRIH FCIIDTI01; S1TIB
tCIintlOI; 15BBSIOS
a) inalyzel at Dniversity of Cardiff
t) Analyzed by laboratory in Paris
Earencaysa ftoa case of pleura 1
scsothelioia

lOlISS; ISEZSTOS; IE07L1SBS;
CCBFIIITITI ETllOaTIOIS; BK1SUBEREH
BIIBODS; FBItCB



33-72 yr olds «ith 1-50 yr
occapationl exposare

ISBtSTOS; OCCOP»TIO»ll HlZiBDS;
10I6S; IIDOSIBIal ITBOSPflEBES: COST;
ItlKt
(BUT P»Gl)
SIFEBEICK

Birsch, a.
Bignon, J.
Sebastien, p.
Candichet, a.
1979
CBIST 76:697-699





















Carter, S.I.
Taylor, ».?.
1980
Environnental Be search
21:85-93









Sebastien, P.
Billon, n.J.
Janson, X.
Bonnand, fl.
Bignon, J.
1978
archives des Maladies
Prafessionnelles, de
(ledicine dn Travail et
de Secorite Socials
(Paris) 39(»-5):229-2»8
Biqnon, J.
Sebastien, p.
Honchaax, G.
Btibnaad, G.
197*
IISEHB 29:205-218



-------
Ifbestos
1332-21-4
IIACT COBPOSmOl niKSOJI OB BISZTE8BIBBB
1ISSDE JMOSOBS SODTB AIAITTICAL lOaBSB IAIGE | BEAI | CBIMI1 IIFOB8ATIOB I BMBBBBCJ
BSTHOB 0? CASES 1 1 |
1 1
3604 IB 1 1.5-3x10(1*6) ferruginous
long bodies/cc
1
1
1
3605 Bicroscopy a) 200,000-700,000
lung fibers/cc
b) 85-135,000 fibers/cc
1
1
1
1
I I
1 1
3606 1 I Sicroscopy 5 «4- 7,840 asbestos bodyyg
lung 1 1 1 (vet vt)
1 1 1
1 1 1
III 1
III 1
II 1 II
II 1 II
11 1 II
II 1 II
II 1 II
II 1 II
II 1 II
III II I
lot given I Intopsy saterial | Sebastien, P.
1 1 Janrand, B.C.
I Occnpationally exposed «6 yr old vith 1 Bonnaad, G.
I flenral nesotheliona. | Gonl, J.
1 I Signon, J.
| ASBESTOS; OCCOPATIOIA1 B1ZABDS; 1 1973
I 10IGS; AOTOPSIBS; BEOPIASBS; FBAKE I Archives des Baladies
1 | Professiognelles. de
1 t Hedecine du Travail et
1 1 de securite Sociale
1 1 {Paris) 34(6) :335-344
1 1
a) lot given 1 i) (orkers handling rav asbestos
b) lot given I r) (orkers nanufacturlng nsbestos
I (toduets
1
1 33-16 yr olds, vith various diseases
I occupationally exposed to asbestos.
| ASBESTOS; OCCDPATXOIAL BAZABBS:
I IDIGS; OCCOPATIOIal DISEASES:
I IBTOPSIES; HDOSTBIAl ATBOSPBEBBS;
I COST; FBAICE
1
1
lot given I Averages of upper and lover lobes, «
I or - 1 SO. Autopsies.
1
1 3 forser asbestos pipe insulation
1 vcrkers and 2 patients vith
1 asbestosls, lung cancer and pleura 1
I aesothelioaa. Ages 48-73 yr.
1
| ACTCPSIES; CCCUPATTO1L HAZAIDS;
1 IIOPIASHS; DISEASES: ASBESTOS; I TIKIS;
| IICTIT
1
III II 1 1
1 3607 | 1 Bicroscopy 1 1 a) 1-20 ferruginous 1 a) lot given I a) 41 eases
1 lung II II bodies/cu a 1 b) Dot given I r) 38 cases
1 1 1 1 | b) 21-100 ferruginous I c) lot given I c) 18 cases
II 1 II bodies/co • 1 d) lot given I 4) 3 cases
II 1 lie) 101-1000 rerrugiaous I 1 lo significant correlation vith sex
III 1 bodies/cu a 1 | or occupation. * of cases vith
II 1 Id) >1000 ferruginous 1 1 21-100 bodies/cu a increased after
III 1 bodies/cu s 1 1 age 60. • of cases vith highest
III 1 1 density decreased after age SO.
1 1 1 24. 7« of cases vith highest density
1 1 1 lived in Paris.
1
Autopsies, 13-91 rr olds, rural and
urban areas, France.
lelatlonship vith lung cancer eannot
r« accurately analyzed because 9M
vere snokers.
TlllCt: 1COIISCEITS; ADULTS; AGt;
AUTOPSIES; nopiASBS: IHIGS:
ASBESTOS; ATBOSPRni: BU11B HI! AIDS;
1IBA1ATICI
1
1 Chatel. A.
1 Blgnoa, F.
1 Sebastieo. p.
1 ftlrsch, A.
, 1 Bignon, J.
1 Bader, J.-p.
1 Chretien, J.
1 1978
I 2:459-464
1
1
1
1 Soggli. T.I.
1 Greenberg, S.D.
1 Bclarty, J. I.
1 Burst, G. A.
1 Spivey, C.G.
1 Bieger, I.B.
1 1980
j Archives of
1 otolaryngology
1 106:533-535
Bignon, J.
Goni, J.
Bonnaud, G.
Jauraad, H.c.
Dufour, G.
Pinchon, B.C.
1970
Enviroasental Research
3:430-442
(HIT PAG1)
-------
Itbe*t03
1332-21-*
IIICT couosrnoi irinofi as OICZTEEHXIED
iissdl

3608
lang











3609
lung















3«10
long






3E11
Loag












IIPOSDIE iOUTf

lageatlon











Inhalation















Inhalation







Inhalation













*»LT1ICU
SBTHCO
EH











EH
Hicroscopy























EH













WO«BU
or cis 33
a] 20
b] 32











1















9







a) 22
b| 22
O 22
d) 12
e) B
fl 1*








(USE

a) not given
h) lot givea










	
a) lot applicable
b) lot applicable















1000-10 f!*61 ferruginous
bodies per en ci






a) lot giT
b) lot giT
c) Sot giT
d) lot giT
e) lot giT
f) lot giT








IE11

a) 570.6110(8-5)
Cibers/g
b) 11«3. 7110(1-5)
tlbers/g
ish wt









a) 46 ferruginous
bodles/ag
b) 3500 fibers/ag
Dry »t














•ot given







a) 3.7 » or - 1.8
fibers/ng iast
b) a. s * or - 2.5
Eibers/ng dost
_S) SO * oc - 81
fibers/ng dnst
I) 171 » or - 201
fibers/Kg dust
e) 322 .or - 351
Cibers/ng list
() »55 * or - 502
fibers/ng dust


GEimL IIPOBHUIOI

a) Controls
t) lesidents with long tern, high
level expoiin froa drinking
coataaiaated water
CtrvsoHle fiber*
1 1 tops lea
S;-8« jr oia residents near tacoaite
rcocessiag claat. linnesota. 17-77 11
eld controls, linnesota and Texaa.
•XIIESOIa; TIUS: IDIOPSIES;
IlttSTUtS: UT»; tDIGS: OBIVKIie
Itini; ISDUSTKIII BBI5SIOIS;
IICDSTSIil fClLOTIOl; 11TEE
IOIIOTI01: 1SBESTOS
liter aean length 2.8 a. Bean
diaaeter 0.13 a. Hore asphibole thaa
chcisotile fibers
tulaomary parenchvaa staples.
51 vr old patient. Exposure between
age: 13-15 vr in welding factory aad
tetweva ages 20-40 vr as electric arc
*il4er.
Paemocoaiosis, bronchitis. Beaiga
tcltp on Total cord.
long opacities, costophreaic aagle
cfcliteratioa, pleural wall thickeaed.
rtllCE; ICOIIS; USE HISTORIES:
IIOOSTBIH DISUSES; IIOPLIS8S;
CCCOTJTIOlll DISUSES;
fiioiocaiiosis: imrcs; LTIPB VODES:
EioiccointiTio": FIBIIS; ifBiniioi;
JSEISTOS
tata correlated well with ember of
fibers in spotaa.

labestos wocters. teao. age S4 vc.

1C1ICE; ID011S; IESPI1ATOBI
SICSETIOI: IIDU51BHL HTGIEBE:
ISEESIOS: OCCOP4TIOSH. HaZlBCS
a) loraal tissue
t) Spoataneeac Maathellona
c) Occipatioal aesothelioaa
d) isbestosle with aesothelioaa
e) tsbestoai! with bronchial
carcinopa
ft labestosis

OccapationallT exposed workers.
Cersanv

6ISB1IT: lOTOPStES; I»DtJSTBI»L
CISEISH: iniSS; tSBESlOS; flBEIS;
J1BIHTIOM; CCCOP1TIOIII. BiZlEOS
BEFEHEIC1

Carter, B*E.
Tavlor, i.f.
1980
Envlronaeatal B« search
21:85-93









Hirsch, 1.
Eigaon, J.
Sebastien, P.
Gaadicbet, I.
CBSSt 76;«97-699













BigaOB, J.
Sebastien, P.
Jaurand, fl. C.
He*. B.
197*
Eavlronaeatal Bealth
Perspectives 9:155-160

Triedrichs, K.K.
Otto, B.
1981
aaericaB Industrial
Hygiene Issociatioa
Journal 42(2)3150-156








(HIT Pl«)
-------
Asbestos
1332-21-*
met COIPOSIXIOI onion* OB BBBETEBSIIED
                                                                                   (COITIIUED)
TISSUE



3612
inng












1
1
1
1
1
1
3613 |
i £rspi> i
1 node |
1 1
1 1
1 1
1
1

1
1
1
1
1
1
1
1
1
1
1

1 1
I

361*
tespirato
rr
secretion




















1 EIPOSniE BORE AIAIRICAL I08EEB IAIGE IEAI I Gllim IlfOllATIOl 1 IEFESEICE
t HBTHOD OF CASES 1 I
1 1 1
1 II
Inhalation Hicroscopy 21 a) < 0.1-370X10(1*6) a) «3.27X10(E*6) | a) Dncoated fibers, death fron I Dorgan, A.
fibers/g fibers/g | nesothelial tnnors | Holies, A.
b) 3.a-11SOOX10(E*3) b) 1783.7«X10(E*3) I t) Coated fleers, death fros I 1980
1 fibers/j fibers/g 1 lesothelial tutors | British Journal of
1 fibers/g I fibers/g I cancer | 37:25-32
I fibers/g I fibers/g I cancer |
1 e) < 0.1-2. 1X10 (E*6) 1 e) 0.«SX10(E*6) | e) Oncoated fibers, non-cancer deaths I
1 fibers/g fibers/g I f) Coated fibers, non-cancer deaths 1
1 f) 0-210X10(1*3) fibers/g f) 28.93X10 (E*3) I less than 1* of coated fibers "era < I
1 Dry (t fibers/g 1 10 on long. 10* exceeded 80 an. I
1 • Dry »t I I
I lecropsies, 19-88 yr olds. Cancer 1
I cases occnpationallr exposed. Onited I
| Ulngdon. I
1 1
| | ASBESTOS: IOIGS; CABCIIOGEI; |
| | CCBMMTIU ITllOATIOIS: OIITED 1
| | KIIGDCH; OCCOPITIOI »L S1Z1BDS |
II II
1 III
Inhalation 1 EH 1 a) lot applicable a) 0.7 ferraginons | Filer nean length 3.3 o, nean I Birsch, A. |
1 Bicroscopy 1) lot applicable bodies/sg I dianeter 0.15 u. (tore anpbibole than I Bignon, J.
I b) 6, (00 fibers/ng I chrysotile fibers I Sebastien, P.
I Dry »t j lediastinal lysph nodes. I Gaudichet, A.
1 1 1 1979
1 1 1 51 rr old patient. Exposure betireen I CHEST 76:697-699
II II ages 13-15 yr in (elding factory and I
111 | | letween ages 20-«0 ji as electric arc 1
III 1 1 (elder. I
III 1 1
III I Eneanoconiosls, bronchitis. Benign I
III I FclrP OB *ocal cord. |
III 1 1
III I long opacities, costophrenic angle I
III 1 otli tented, plenral (all thickened. 1
1 1
1 1
1 1
1 1
1 1



Inhalation
.




ES



























a) 8
W 7
c) 5





















1








a) 20-2000 ferriginoas
bodies
b) 10-20 ferrsgiiKMs
bodies
c) 0-10 ferrnginons
bodies


















| FIAICE; 1EOITS; CASE BISTOBIES;
| IIDOSTBIII DISEASES: IEOPLASBS;
| CCCDPATIOI1I DISEASES:
1 tiBtrsocoiiosis: miss; LTBPB IODES;
| EIOACCOI10IATICI: FIBE5S; HB1LATIOI:
I A5EISTOS
t
1
a) lot gires I a) High risk exposure for 15 rr
b) lot given I t) Sod era te exposure for 25 jr
c! lot gives I c) Insignificant exposere for 28 re
I falnes for spntns
1
I Ccctpatlonallr exposed persons dth
I thoracic pathology related tc
j asbestos
1
1 Chronic bronchitis in 651 of 18
I stokers and the 2 ton-stokers.
1
I librosls, calcification of pleata.
1 cancer of the Inng or pi Mr a.
j lesions of snail airways foud in 80*
j at cases.
1
| ItAlCE: IICOSTIIAL DISEASES:
| KOtLaSlS; CCCIPATIOIA1 DISEASES:
| llSPItVTOtT SKIRIOIS; ASBESTOS;
1 inns: itAHB BIUIBS: IID
-------
libastos
1332-21-*
tun coBFosmoB imoii 01 oiminmio
                                                                                (CORIIHED)
1XSSBB
3«15
Basplrato
ry
secretion




3616
lesplrato
ry
secretlos



3617
Spatan



SXFOSBBS Milt
Inhalation




Inhalation







tinmen
BET8OD
ra
Bicrescopy




Bicroscopy



licroscopy



•BBIXB
OF C1SIS
2




•t <«
b) «2
c) 16



«» 13
b) 16
e) «5
d) 6«



Hies
a) let applicable
b) lot applicable
c) lot applicable




a) 2-10 ferragiaoas
bodies (n)
b) 2-300 FI
c) 3-1500 FB



a) 0-1 85 0 ferrsgiaoas
bodies
b) lot git ta
c) lot given
d) lot givea


(•JIT
BBIB
a) 20 ferraginoes
bodies/sasple
b| 3 ferzaglaoa*
bodies/Maple
c) 50.000
fiber s/saaple




a) 1 fecragiaoaa body
(FB)
b) 10 ra
c)' 100 IS



a) lot given
b) 100 ferragiaou
bodies
c) 10 fetcoginoas
bodies
d| 1 feccagiaou bolr


Plot)
GIIII1L IITOIIHIOI
a) latleat 1
b| Patieat 2
c) Patieat 2. Fiber aean lengtk 2.*
i, aeaa diasatet 0.10 a. loce
ektysotile taaa aapaibole (ibers
Talaea tor sfatas
fitieat 1, age 51 yr. Sxposare
tataeea agas 13-15 yt in neldiag
factory aad fcataeea ages 20-«0 yc as
electric arc (elder. Patieat 1,
itoker. age !• yr. Iea*y erposare ia
asbestos ceseat plant, pre-lorld Bar
2.
•aeasocoaiosis, broachitis. Beaiga
pclyp oa vocal coed (Patient 1) ,
iqnaaxiM cell carciaoaa of Itryai
(tatlent 2) .
laag opacities, costopkreaic aagle
ctllteratloa, pleeral «all tblcfcaaed.
isiBCB: IDVITS; CISB msTOKES:
IltHSntU CISUJBS; IBOPUSBS;
CCCOVITIOIll DISUSES;
(Koaocoiiosis; miss; LTIPB BODES;
!io»ccns
-------
   »tl«stos
   U32-21-*
   II1CT COBFOSItXOI
                             Ql U»BB«MI».HS
                                                                                          (C01TIT7EO)
IlSSffJ



3618
Spotaa









3CI»
snataa












Biposme sour




























iiiinieiL
BBTBOD


EB










licroaCOBT






HIIIBJB
OF CISES


1









— — — «__ „.













SJ»C!



lot given










	 iili 	 eiiuat urossi'ioi 	



300 ferruginous Occupational!? eiposed, lit. plenral
bodies/sasple sesotaelioia
1
I f( jc old (an
I
1 ISBtSTOS; CCCOVHtO.al EJ21SBS;
1 .rocs: AUTOPSIES; matusas; tsact
I
I
1
	 szrEtnci 	

i

Sehutlea, P.
Janraad, H«C.
Poaaand, G*
Gonir J.
Pignon, J.
1973
archives 4ea ealadies
Piofessiooaelles, de
Hedeeloe 4o TcaTail «t
de Secarite Sociale
1 (Paris] 3*{(]:33S-3«*
a) 29-523 f iberi/saapla 1 a) lot given I a) Sorters ta-dlig? rav asbestos chatel, 1.
b) 0-
-------
Enxaldebyde
100-52-7
C7-B«-0
Bl IOC.12, BI -26 C, BP 179 C. ?P 1 •• 19 at 26.2 C
irsstii

3621
Breatk










3622
Breatk












IXPOSVBB B001Z


























lEUTTICal
BETBOD
ec/BS











GC-BS












»D8B!S
OF CASES
9











54 (387
saaples)












BJIG1

lot detect ei-1. 5 ttg/ar











Bot given












Bill

0.2 ug/hr











0.513 ng/1
Geosetric












GBIEBal IirOSBITIOI

Ccipoiad froi unknown origin. Bo
ctker details given
cryogenic saspling teckique.

Bealtky nilltary and civilian
esployees, U.S. air Force School of
lerospace Bediclae. ages 23-47 yr. 3
tiokers.
EEIZEBES; CBtOBXEaTZB BTDBOC1BBOBS;
CBIOHIH oBcanc COSPODIDS;
CBLCBOBEBZZBIS; FLOOB.XBE COBPODIDS;
EBE1TB; I1CCBOLS; TBIIS; 1COLTS
Beaauced at 25 C and 760 ss Bg
2*. It occurrence
lexer and upper one-Slgaa Halts
0.15) and 1.6« ng/1

Bealtky. 18-35 yr old. nonsnoklng.
artan blacks and Caucasians.
Chicago, II. Rigidly controlled
eiperlnental conditions.
tBIITB: IICCEOLS; ItlXBOIS; aDOHS;
CElOBUiTID ETDBOCIBBOBS; TOLaTILE
CIG1BIC COBPCOTBS; BEallB BlZaBOS;
IIBIltTICB; BRIEOLISB; BETaBOLITES;
EOPOlaTIOB EIPOSOBI; OBB1B IBEaS
BEFEREBCE

Conkle, J.P.
Caap, B.J.
Belch. B.E.
1975
archives of
Environmental Health
30(2);290-295





Krotoszynski. B.K.
Bruneau. G.fl.
O'Heill. B.J.
1979
Journal of analytical
Toxicology 3:225-234








Einzena
71-»3-2
CC-B6
>< 78.11, n 5.S1 C, BP 80.093-80.09* C, TP  10  nn  Eg  at 26.1  C
IXSSOI

3(23
Breatk










362»
Breatk












ElPOSalX BOOTE



























llUTTXCal
BETRCD
SC/BS











SC-SS













IDHBEB
OF C1SES
8











54 (387
saBples)












Bliez

lot detectsd-250.0 ng/kr











Mot glren













BEal

40.8 U9/hc











».3 ng/1
Geonetzic












GE1IBI1 IIFOB11TIOI

Prevloas eipcsvre to conponnd. Vo
ether totallf given
Ctyogealc saipliag technique.

BealtkT illltary and civilian
eiployees, D.S. llr Force School of
leroapace ledlclne, ages 23-47 TC. 3
stokers.
tmtns: CBIOBIIITIO HTDBOC»BBO»S:
CeiOBXI! O«G»IC COHPOOSDS;
CE1CBOBEIZIIIS: PLOOBXI! CCBPOOIDS;
EPiHi: iicceois; TEIIS; mtn.'is
leasared at 25 C and 760 n* Bq
41.1* ocearrcnce
lever aid upper oae-Sigaa Halts 1.6
and 11.3 nq/1

BfaltbT, 18-35 rr old, nonsnlciag.
artan blacks and Caucasians.
Chicago, II. BigiaiT controlled
ctp«rlaeatal conditions.
IBEaTB; HCCBOtS; XILIIOXS; IDtriTS;
CELOBI11TED ETOBOdBSOIS; TOllTXIE
CEGIIIC CCBECTOBS: BSI1TB BH1EDS:
IIBlItTId: BETlEOlXSa; BETIBOLXTXS;
ICPOLITIOI EXPOSOBE; 3BBal >SEaS
EEFEBEBCE

Conkle, J.P.
canp, B.J.
Belch, B.E.
1975
arckives of
Environmental Health
30(21:290-295





Krotoszynski* B.K.
Brnnean, G. B. '
Ofleill, B.J.
1979
Journal of Analytical
Toxicology 3:225-234








-------
       Beaseae, cbloro-
       1C8-90-7
       CI-B5-C1
       »  112.58, BF -«S C, IP 131.7 C. TP 10 »
                                                  at  22.1 C
TISSUE
3«25
ireatk

EXPOSTSB BOOTI


i uitmcn
f ffXTBOD
OC/HS

ETFBZE8
OF C1SI5
8

BUGS
lot giTaa-a.OO? a«/fcr

BE1I
0.01)03 ig/hr

CEIEB1L IBFOSBaTICn
Ceapoaal fcoa aaJuton origla. to
ether detail* qlnn
Cryoaeatc aaapliag teekaiqae.
Bcaltkj eilttarr aad civilian
aaplorees, U.S. air Fore* School of
lerospace Bediciae, agea 23-«7 jr. 3
IIBtBBES; CBlOBtBlTtI BTDBOCUBOBS;
CnCBIBI OBG1BIC COBPOBBOS;
CELOEOBNKBES: FLBOillg COHPOHIDS:
CIB1TB; IICOEOIS; TBtlS; IDVtTS
BEPIEEBCI
Cookie, 3. P.
Caap, B.J.
felck, B.E.
1975
IrcklTes of
t»iniiaeital maltk
30 (2): 290-295

     Emma. «tk|l-
    CS-IIO
    Bt 1»(. 1«. Bf -94.97 C,  BP 136.25 C.  TP  10 •• Hfl at 25.9 C
    I  1ISSVS
                 sxtosmy tent t
                                                       OF C1SIS
                                                                                                                               entiu HFOSBITIOI
     3626
 I
 I lahalatlon

 I
 I
 I
I
  I
  I
  I
  I
  r
_i_
                                                    I  «

                                                    I
                                                    I
                                                    I
                                                   I
                                                   I
                                                   I
                                                  .1	
                                                                   0.50-0.80 a9/1
                                                                                              0.6925 a
-------
f*i**ie, aeiackloro-
C6-C1«
If 28*. 80. » 231 C.  tt 323*326 C, TF 1 •• Bg at 11*.* C
IISSVI

3C29
adipose








3630
adipose












3631
Blood
















niosntE Boott























lagestioi
labalation
Deraal















alllTTXCll
1EYIOD
ec








OC-BC





























main
or CASES
60








a| 22
b) 1*
cl C
d) 6
e) 6



























11KI

0.23-10.70 ppa








a) lot give«
b) lot given
c) lot given
d) lot given
e) lot given










a) 5-1121 ppb
b) 30-9)0 ppb
c) 3-600 ppb
d) 22-«67 ppb
e) lot given














Sglt

1.36 ppa








a) 0.2* » or - 0.09
•g/kg
b) 0.36 » or - 0.2*
ag/kg
c) 0.12 * or - 0.06
•gAg
d) 0.08 «or - 0.07
e) 0.09 4 or - 0.03
•g/kg






a) 310.7 * or - 287.7
PPb
b) 311.5 » or - 2*2.9
ppb
c) 159.9 t or - 1*2.7
PPb
d) 170.3 » or - 111.8
ppb
e) 0.1 * or - 0.6 ppb










Ctmil IIFOIBITIOI

Feripheral tidier fat. roatlve
pathological •xaaliatloas

Iges 6 IO-92 it. Belgian

BHBIBI; 10TOPSIES: IDIPOSE TISSUE;
tlOaCCOROllHOI: PESTICIDB3; DID:
IK; OBI; DIUOEII; HBPT1CB1CB
IPOIIDI; BIIICB10BOBZBIEI1; III CUE;
CBIOBIIB oiemc COBPOOIDS
,
•1 Ilderlr icn
b) BlderlT «enen
c) Toiiq I*B
) Bevborns
crlrenal tissae
176 survey.
•topsles frei 3 donor groipa.
v«rage ages 70 "vr. 2* yr. and 25-35
\, Oslo, lonaj.
ItltOSB TISSBE: BILK; COHPlilTIVB
IflLOiTIOIS; IOBIII: IDOItS;
iVTOFSIlS; IIW8O1I; CnOBIIlTED
BTBBOCISBOIS; IDT: PBSTICIDBS;
ICITCBtOBIIlTtO BIPIMYtS
a) SO exposed vorkers. 197*
b| *9 exposed corkers, 197S
c) *9 exposed vorkeri. 1976
dl «* exposed vorkers. 1977
e) ** controls. 1977
a)-d) aaalrzed by different
lafcoratories.

laplorees of a chlorinated solvents
plait in Ibcrillle parish. 11.
197*-1977. Controls worked In a
polyethylene prediction plant.
Be detected dif fereaces betveen
exposed and controls studied in 1977.
BIIICHIOBOBEHBB1: NI6ICIOIS; BLOOD;
IICDSTIIU. FLUTS; OCCOPITIOHL
iiziiES; let: siciiL STUDIES;
iiinsTiiii iTHospBnis: iionsniit
JICIEIB; COBPU1TITB EY1LU1TIOIS
BIFEBCTCI

Dejoaekheere, I.
Steirbait. 1.
Terstraeten, B.
Rips, I.E.
1978
Toxicological European
Research 2 (2): 93-98



Brevik, E.R,
Bjerk. J.B.
1»78
icta Fhariacologica at
Toxleologica
•3(1)8 59-63









Carrier, I.F.
•cCliians. C.D.
Bana-lloyd, 6.
1980
Joarnal of Toxicology
aid SivironMBtal
Bealth 6:367-377












(HIT fjtet) ' '"
                                                                                                                                                                                           OJ
-------
CcnzeM, aesacaloro-
ce-ci«
1< 28*. 80.  K  231 C, BP  323-32* C, »P 1 u tg at  11*.* C
























IISSO! BIMSOIB iOOTE UllTTICtl
B1TBCD

3632 00 K
Blood,
ibol*


















1
1
1
1
1
1
1 3f33
1 Bilk
1 1
1 1
1 1
1 1
1
|










GC-EC
SC/BS






1



363«
(Ilk


1
1
f
1
1
1









flTSBES
or cises

*) 35
b| «

























a







fUGS


a) 0.1-3 ng/g
b) 0.1-1 ng/g

























.6-17.1 ng/kg







1
1

I - - -
Bill | GBIrBII I»TOBB»TIO« 1 BKnBEXCX
I |
1 1
a) 0.6 ng/g | *> lore cannl reaidenta, 100T ( Bristol, B.I.
b) 0.3 ng/g 1 to«lti»e caarlea 1 lego
I b) Tolnateer*, 10M positive aaaples I IPI-600/1-80-036, 40
1 Halt at aeatoreaent, 0.011 eq/y | pp.
1 ClctelT aatctol, siaqltaaeoai control I
1 *a*Bl«< vere not pcovttod tor 1
1 i*aly*U along «lta those froa the 3* I
1 Icve Canal area residents aaapled. I
1 lacking aeacingf ol control ot I
1 llteratare data relative to tbe 1
1 ctgnifieaac* of the lo* r«»ldne» I
1 foand la tie field saaplea analrr»d, I
1 no definite conclnslons can be dran I
1 fro* tan reialta reported. (
1 1
1 I««ldents ot >•* lork. Controls, I
1 eaploye** ot the Zsvironaental 1
1 Protection Igeacr and oalveratltT 1
1 «tndeot». Berth Carolina. 1
1 1
t «!« TOSH: IOFTH CUOIIll: EICOD: 1
1 Btismnm Brrsons; CBIOBIBE OSGIIIC i
1 CCBfONBS; CBIOFOBBIIIIBS: 1
1 ItllCnOlOBtKEBI; POirCSLOSMJTIB 1
I HPBiiiis; pcpoiairoi Bifostjsr i
1 1
1 1
.9 «g/kg I Uctatiag aetbers 1 Sodrlc-Snit. R.
1 1 salt. -L.
\ 17-41 vr olds fro* Slavonia Province, 1 oil*, X.
1 Yugoslavia. I I960
1 1 Pesticides Honitoring
1 locosmn; uctalioi: Kin: i journal 1*(1>:l-2
1 iiotccmnKio* ; BBUI aa»s; i
1 CKCtlMTEC BTBBOC1EBOJS; C BIO 8MB I
( CEGMTC COHECTTSDS: CHIOJOBSIlrBtS; 1
1 tIE: DDT; BinCBIOBOCTC£OB»IBB: 1
1 HSTICIDIS 1
1 1
ec-BC I a) 14 aj *ot girt* a) 5.5 • or - 3.7 a) Oslo, large iadusrrialiled city 1 Brer Ik, E.a.
1 b) 11 b) (at girea no/kg t) Berqea. large iada»trialin>a city I Bjerk, O.B.
O 10 c) lot giren » 9.2 « or - 4.0 c) Barstad. saaller dtr vitb large I 1978
6J 9 &) Bot given ng/kg cbealcal/petrochealcal complex 1 act* PbarMcolo?lca et
c| 2. 7 + or - t.O d) Porsgrana, aoa-lBdastrielizod' 1 Toxlcolo?ica
ag/ltg flaking coasmity 1 *3(1|:59-«3
i) 3.2 « or - 1.2 U7« sarnv. Significant difference 1
ng/*g (f < fl.OSI tttveen saapllag *lte»: I
EC r gen > Oale > Barstad, PomgcuiB 1
t
looegian aether*, ages 25-28 ir. f
1 ICIP05I IISSBE; «n.K: COBPJSlTIfF I
I cmgiTiois; IOKIIT; tcans ; \
1 IttOPSIBS: BHBOIB; CBtOBHHED I
1 BUBOCtlEOBS; DM; PISTICIOIS: {
i i fcticaionmiD fiPBfins i
1 1 1 1
-------
It ami*, o-aickloro-  (8 CI)
E«I»M. 1.2-aickloro- (9 CI)
CC-B«-C12
S« U7.«, HP -17.5 C, Sf 1*0-183 C,  T*  1  «  Bg  »t 20.0 C
TISSUE

3«35
Btaath










BiniOBS BOOH












iiitnicii
BRIOD
8C-BS










•DBBM
OF CaSIS
» (387










IIICX

lot gl*«










1EII

2.* ng/1
Seoaetric










SEiitiL nrotamoi
	
Masnct at 2S C ana 760 a* Bg
13.91 oceimnc*
lovtc a*a «pp«r one-Sigsa Haiti 0.«3
aaa 13.5 ng/1
Kalthr, IB-IS TC old. aaaanktig,
attaa blacks ana Caucasians.
Chicago, II. Bigidll conttoll«d
.
Obi, 6.
1975
EBTironaantal Pollntioa
8:2««-274




-------
    Mama, p-ajckloro- (t cxt
    mm*. 1,1-M.cklora- f» «)
    1M-M-T
    ee-t«-ci2
    II 1*7.01, It S3 C.  W »7«.«  C,  Tf  10 M tg «t 5*.« C
TJS3BS

3S38
flood.
• boll






3639
BMatk











xuosm *om

Inkalatio*





















I uitmcu.
imoB
8C






1
I
IK- as












tmtst
or C»SB
c








M per
•UplM)











1MSI

•-16 »g/»l








•Ot 9iT«l












IUI

9.5 »g/«l








1J.« ««/i
e*a»t£ic











czitui inoiMtioi



IWltkf Jll «t 2S C «»a 7<0 » M
»t.« occ«ci:«c«
tewr «»4 BFp»r aD*-sl4M licit* ».t
lid J«.3 «?/l

I«althr, 18-35 Tt oW. non*»oti«q.
it tin blacka Md csteuikB*.
Ckleago, n. Hflldly emtroUcd
«ip«rlM>t«l condlticua.
(I»T«; HCOtOU; IUIVOIS; IDU1TS;
cnciiuiie miociiBois; »ot»rn.e
CSSIPIC cowcnD5: IUITB miBos;
HBJiiTici; maeoiisa; SITJKHITBS:
FCCIIIIICK EITCSVn; OlUt *SU3
nnma

Borit«, S.
Oki, 6.
1475
z>Tiroi»«Bt«l Fellatio!
8l2«»-27»




troto«T»ki< B.K.
Era, S. S.
O'KUJ, H.J.
1»7»
Jooreal of Unljtictl
loilcologj 3:225-23*








t«MM. fntackloco-
ce-»-ci5
» 250.3*.  Bf 86 C, IP 277 C
1 IISSO!
1
•
1
1 3MO
Bilk









1 iiFOsaii IOITTZ
1
«
1











I 1M1TTIC1I
I BVTH00
t
t
i eoic
t OC/TIS
I








I train
i or c*si5
i
i
1 6
1
1
1
|






1 11KI
1
1
1 0-3.4 «g/t-j
1
1

t





'
1 atti

2.0 ng/*j










1 Gtitiii nrotaiTioi
1
I
tictttiiq ietk«t*

1J-»1 fr olds fro* SlaMiia (rotlic*.
I*«o*l«ri«.

TCCOSHTll; ItcIlTIOl; Silt;
BJOICCOSOIITIOI; IDIU U»S;
CKenntn mBoctiBois; cnoim
cienic coatents; cnmoBiizsus:
tti: on: nxicnoMcrcioMUit;
fISTICIDIS
Kninrcz

Io
-------
ftate«e, peitacaloroiitro-
82-CI-8
C«-C1S-C-02
HI 2»S.«. BF »6 c, BF.328 C. It 0.013 •• Bg at 25 C

36*1
Blood,
•bole





















ElfOSOR BOOT!























1U1TTICU
BBTBOD
OC-EC






















miBEE
or cuss
a) 35
b) 11






















MICE
a) lot applicable
b) lot dttacted






















•Ell
a) 0.2 nj/g
b) lot detected






















CBIIBII IirOBBHIOI
-
a) Love Cagal reaideats, 3* (1)
tctitive
b) volonteeri
lean of positive saaples. Llalt of
aeasareaeat, 0.1S ag/g
Closely aatched. sinltaneoas central
saaplei vere not provided for
aaalTSis alaag *ith these free the 36
love Ctial area residents aaapled.
lacking seulngfnl control er
literature data relative te the
significance of the Ion residaes
feind in tbe field sanplos analyzed.
ao definite coaclvsloas can be drain
fios the resells reported.
Itsidents of lev York. Controls,
eaplovees of the Environmental
Iiateetiea leaner and wtlveralty
(tadents, lorta Carolina.
Ill YOHKs IOITB CUOlIIl; BLOOD;
ItlSgiNBII IETBODS: CB10BIIB OBGaRC
CCBFOniDS; CBLOBOBIIZSIES;
IIIICBlOlOBEnEIS: FOLICHlOllmBO
IltltlTLS; POPOL1TIOI SZCOSOBE
BEIXBEICE
Bristol, D.I.
1980
EPI-WO/1-BO-036. ao
pp.




















Baana*, propyl-
103-65-1
C4-I12
II 120.2. If -99.5 C. BP  139.2  C, TT  10 ••  H« at «3.»  C

36«2
Breath










IUOSHIH SOOT I











1HIITIC11
BBTBCn
	
0C/BS










•OIBES
or CISBS
a










tllSE
lot detect «d-6. 5 ag/hr










mi
1. 1 ag/hr









"
6IIII1L IIPOBB1TIO1
Ceafonad related to noraal
••tabolisn. lo other details given
CrTogeaic sanplinq tecbnigee.

Bealthy ailltarr and civilian
eiplovees, O.S. air Force School of
lerospace Hediclne, aaes 23-»7 vr. 3
aaokers.
EIlZEIfS; CBIOBII1TED RDIOC1BBCIS;
CIIOIIIE OIGHIC COIPODIDS;
cncMiNZBiis: rtnonii coipoms;
fltlTB; alCOBOlS; tBZIS; 1DH1TS
BEIESEICE
Coakle. J.P.
Canp, B.J.
nich, B.I.
1975
archives of
IiTironnental Health
30 (2): 290-295





-------
     IJSS1-13-7
     C9-B12
     » 130.2. » -2!.37 C, BP  576,1  C.  V* 100 •• Kg at 108.8 c
tissn
3««3
Cnatk










nfOSOBB BOOTS












iiUTTXcat
BMBOr
EC/IS











Btnuxi
or cuss
8











met
lot d«t«ct«4-9.3 ag/ar











nil
1.2 ag/bt











CZHMI nroBHiiar
Compound fiei aakaon origin. la
ctkct fetalla gi»«n
CXTogvilc aaipliag teebaiqw.

Maltkr •ilitwr a»J cirili.B
• •plor*«<, U.S. lit Fore* Sckool of
l«Mp«c« RcUclM, <9«s 23-«7 jr. 3
••okcrs.
Zfl»»S| CBtOIIMTZO BtOSOCIfiBOBSj
cnoim atcinc cocfomos;
C81O10BH2II1S; nocim caimnos;
tuiTi: ncoeoLS: THIS; loans
nnum
c«n>kl«, J.P.
C»*p, B*3.
»lch, B.I.
W75
»rclil»«« at
XmrlrauutU Mlltli
30 {2)1290-295





    l«0-«7-0
   C1-B5-I
   HI 103.1. IIP -12.8 C, BP 191 C,  11  1  M  84 l coaUtloaa.
I
| IBftTB: ilCCBOlS; H1IK113; JOOLT3;
| tnOHBlTIC (IDBOCtSBOIS: TOW Tin
I cismc coBFcmtis: BMITB ginms:
| KEUnlOB: BRaZOLISB: BEHPOLITIS;
1 pcftniTioi ttnsns: aisn »BIJS
•
tErnncx
Krotonyaaki. B. E.
Ecoaaav, 6. a.
O'Baill, B.J.
1979
Jaanal of analytical
Toxicology 3:225-23*










                                                                                                                                                                                               oo
£«»irl«aiB«  (8 CI)
e«ax*MMtaataiim  (9 cl)
1CO-W-9
C7-B9-B
ft 107.2, BP 18- C^ If 1 mm Bq at 29.0  C
X1SSVE
36«5
Bmth












SXCOSOB5 1OOTB














IBllTTlcal
HTBOO
OC-BS













or cisss
S» R8T
caapl^sl












Eire!
lot giT«a













BUI
-
0.007 ag/1
Scoavtlie











1
GEItBlt nroiBlTIOB
Kaaatad at 25 C met 760 aa Bq
12.94 oecarraae*
Ic««r aa8 tpj«t oaa-Sigaa lialta
C.0015 aad 0.0327 aa/1

Btaltky, 16-35 yr oU, aoaaaoliia.
«tttn blaeka aal caicasians.
Olcaqo, II. HigillT coDtrjll«4
-------
leryiitai
7«*0-*t-7
fc
Itl 9.01211, tl 1287 C. BP 2500 C. W 1 •• Hg at 1520 C, 10 aa Ig at 18(0 C
IXSSOI
3S«6
Blood

36*7
Oriae

IltOSOBI MOT!




lULTTICJl
BBTBOD
us

us

•01 BIB
or cisss
10

a) 2
b) 8

BIKE
lot given

a) lot givea
b) lot givea

BUI
1.0 * or - 0.% ng/g

a) 0.9 * or - 0.5
ag/g
b) » ng/g

61IIM1 IirciIlTIOl
Ceatrol valaes. Increase by factor
of * for eiposed groap.
1 persons nocking *-6 kc daily in
at«a vlth Bacl2 leakage aad 2
non-exposed controls. Federal
t«{iabllc ef Cersaay.
CHiiiT; EiocD: DBlii; BiBiuins;
miLS; eoiomioi iirosoFl; B»TS
a) Coatrola
k) Ixponfl gtovp. leak at * 4»T»«
•>ti«ate4 frea graph.
B«B «orki«g «-« br daily in area with
I«C12 l«akag« and aoa-«zpo8«d
ceitrols. federal Bepablie of
Scraaar.
GIB1JUT; BIOCD; DBIfE; BEBT1LIBB:
inns; popotiiioi ncosoBi: BUS
BIFIBZfCI
Stiaf«l. t.
Schnlxe, X.
Zornf n.
Tolg. S.
1980
irchiTes of Toxicology
•5:81-92

Stiefel. T.
Schulze. K.
lorn. B.
Tolg. 6.
1980
Archives of Toxicology
•5:81-92

ti;k«iTl  (8 en
l.l'-Blphwjl  (9 CI)
92-52-»
C12-B10
BI  151.2. tt 70 C, BP 255 C. TO  1  aa Bg  at  70.6 C
TISS1I
36*8
Breatk












BirOSUBB BOD1I













1HLTTIC11
SSTBOB
SC-BS












IOBCEB
or cisss
5» {387
aaaples)












»I6B
lot given












Bill
0.032 ng/1
Geometric












GUlBiL IIFOSa»TIO»
Icanred at 25 C and 760 aa Bg
2C.74 occacrenca
lever aad nppar one-Sigaa liaits
0.0096 aad 0.109 aoyi

Baaltkr, 18-35 TC old, nonsaokiaq.
artan blacks and Caucasians.
Chicago, II. Bigidly controlled
eipcrlaeatal conditions.
EBIJTB; UCCEOIS; IIIIIOIS; tDOITS;
CEICSIHIIEO BIDBOC1BB01S; fOLlTTLB
CBGinc coitcniDS; HIILTB Binsts;
IlBlltTIOl; «R>EOIISfl: BITiEOlITES:
tCPOUTIOH UPOSOBE; OBSiS »BE»S
EErilEBCE
Krotoszyoski, B.x.
Brnaeaa, G. B.
0«»eill, B.J.
1979
Journal of Analytical
Toxicology 3:225-23«








                                                                                                                                                                                             vD
 tiphenjl.  ciloro  (8  CI)
 I.l'-Biphenyl, chloro derits (9 CI)
 1336-36-3
 IIICT COSPOSITIOI DIKIOVI OS OIEnZBBIBZD
TISSDB
36«9
Idipose







BTPOSOR! SOOtZ









1U1TTIOI
HETBOD
GC/HS








BHBEZB
or cisss
16








ClIGB
1.6-3.2 ng/g (fat basis)







CE)
GZIIBaL IBTOBBITIOB


faaples frea hospitals and aedical
exaaiaer's office in Tokyo.

JltlB; «»IFOSE TISSUE; BLOOD:
CBICIOBIBZIIIS; PESTICIDES:
EcucBLoauniD EIPBIBTLS; IIHOSPHEBE

fEfEBBBCE
Borita, B.
Ohi, G.
1975
EnTironaental Foliation
8: 269- 27*




-------
Mphenyl, chloro (8 CI|
.I'-Blphenyl. cbloro aerivs (9 CII
336-36-3
UCT coBPosmoa OIIIOVB OB OBDETEBBIBED
(COBflBtTBD)
iissnt
3«5«
laipose










3651
adipose















3652
Idlpose









3653
Blood














BIPOS0HB BOD1B
























































aEaLTHCU
BETBOD











_
ec-Ec
















OC-SC










EC- EC















B03BBS
0? C43SS
a) 33
b) 1
c) 1









a) 22
b) 14
0 6
a) e
e) 6
O 36











2


























BlBSB
a) Bot given
b) Bot given
c) Bot given









a) Bot given
b) Bot given
e) Bot given
d| Bat given
e) Bot given











	
a) Dot given
b) Bot given









a) <0. 5-8 ppb
b) 1-22 ppb
c) 1-12 ppfc
a) 1-12 ppb
e) 1-18 ppb
f) 1-23 ppb










BEaB
a) 2.6 * or - 1.90
ppn
b) 3.2 ppn, fat basis
c) 4. 2 ppa, fat basis








a) 2.14 * or - 0.86
•o/kg
b) 1.65 « or - 0.83
•g/kg
O 0.92 » or - 0.38
ag/kg
I) 0.63 • or - 0.53
ng/kg
e) 0.90 » or - 0.42
•g/kg







a) 200 ppa
b) 600 ppn









a) 3.0 or - 1.5 ppb
b) 3. 5 or - 2.3 ppb
c) 3.8 or - 2.0 ppb
S) 3.7 or - 1.9 ppb
e) 3.3 or - 1.9 ppb
f) 3.1 or - 2.3 ppb










GBBtBll lEfOBslTIOB
a) Bospltal catlenta
b) 13 vr old resale «lth lasho
e) 46 vr old nale eitb chronic PCB
cottoning

Japan

IClICcTOBIBlTID BIPBIBYLS; DDT;
BIUCRlOIOCTCLOamEB; BLOOD PLaSBA;
Bionisas; Jipai; saSTBOifiBsnaii.
SISTBB: FISTICIDBS; UIPO5C IISSOB;
U»tB; KIDB1IS; OBEBTOB
a) HderlT nan
b) Ilderlr icnen
c) tonng aen
tf) Toong voien
e) Bevborns
lerlrenal tiesae
197C sarvev. Significant increase in
elderly conpared to 1969/70 survey.

letopsies frcn 3 donor groups.
average ages 70 vr, 24 vr, and 25-33
•k, olso, Borvay.
ICIPOSE IISSOE; BULK; COBPIB1TIIB
ITtlOITIOBS; BOBilT; ADtltS:
lOtOPSIBS: BEIBOBB; CBLOBIBATBD
B1CBOCIKBOBS; DDT: PESTICIDES;
ICllCBtOBIBIIID EIPBEBILS
a) Sanple 1
t> Sanple 2
Cose and origin onknovn
Eata also foi 6C/HS, identltying PCBs
(ran pentacbloroblpbenrl to
d«cachloroblchenTl, at loaat 1»
isosers and cl analogs

JCKOSE TISSOB; BEaSOBEBBn BBIBODS;
IOITCBLOEIB1IID EIPBBBILS;
eioiccoainnoB; POPOLITIOB EIPOSOBB
a) 1972. 129 sanples
b) 1973, 123 sanples
c) 1974. 117 sanples
0} 1975, 113 oaaples
e) 1976, 100 sanples
() 1977, 101 sanples
Concentrations highest in 1st parity
nctbers.

180-141 laetatlng voaen, 2 souths
after delivery. Besidents of Osaka
Icefeetnre, Japan, varied diets and
JIPIE; t»CI»TJOB; BLOOD: BIIK;
EioiccnanitiioB; PESTICIDES;
ECITCBIOBIBIICD BIPBBBnS; OBGtBIC
CEIOBItE COBCOHBDS
BETEBEBCE |
I
Inoae, 1.
kbe, s.
Takamatsn. a.
10*1. I.
Blkl, s.
fojlvmra. K.
1S75
raknoka Bodies I Joarnal
66(10:610-616



Brevik. E.B.
Bjerk, J.E.
197B
Icta Pnarucologica et
Toxicologlca
43(1) 159-63











Biros, f.J.
talker. I.e.
Itedberr, 1.
1970
Bulletin of
Znviromeatal
Coataniaation and
Toxicology 5 (4): 317-323



Takasblji, T.
vatanabe. I.
Knvabara, K.
Tosbida, S.
KayaDja, K.
Konlta, B.
1979
International archives
of Occopational and
Envlronaental Health
43s 1-15





(BEIT PlGE)
-------
fipheeyl, chioro (8 CI)
.I'-Bipkeayl. chioro derive (9 d)
33C-3C-3
HCI COBPOSITIOE OinOIB 01 OHITMRIHD
(COBTIBDZD)
jjjSjf - - — — -
36M
Blood








36SS
Blood










3«5«
Elood








3«57
Blood










3658
Blood.
plaaaa









IIFOSO1B BODXI




















Ingestion



















Ingestion









IBURICU
BETBOD
OC








ec










GC-BC








ec










ec









BVBBBI
or cisss
a) 17
b) 16








37










66








a) 2*
b) 15
e) 2
d) 37








a) 30
b) 18
0 11









BUM
a) <0. 2-12.8 ppb
b) 1.7-4.6 ppb








a) lot given
b) tot given
c) lot given
d) 1.25~« ppb
e) 1.8-0.* ppb







11-720 ppb








a) 3-26 ppb
b) 2-11 ppb
c) Bot applicable
d) 1-7 ppb








a) lot given
b) lot given
e) lot given









BE1I
a) 3. 8 + or - 3.6 ppb
b) 2.8 + or - 0.8 ppb








a) 3 ppb
b) ». 8 ppb
c) 2. 55 ppb
d) lot givea
e) lot givea







M ppb








a) 9 ppb
b) « ppb
c) 2 ppb
1) 3 ppb








a) 6.0 ppb
b) 10.8 ppb
c) 3.7 ppb









CBItllt IIFOTB1TIOB
•1 1 10-6 yr olds
t) Bothers of children
Children* s blood level varied »ltk
length of breast-feeding.

lesUents of Osaka, Japan. Bothers
eith no occa rational exposure to KB.

fClTCILOtlBltm BIPKEBTIS; BILK;
BIOOD; CRIltBEl; POODS; PESTICIDES;
JlVftl
a) Bothers. 8 so prcpaxtna. 1977
b) Bothers. » ao prepartaa. 1977
c) Bothers. ; so postpartoe, 1977
d) Breast-fed infants, birtk and 1
yr. rinal valne 1.7 ppb at 3 yr
O Bottle-fed Infants, birtk and 2
yc. riaal Talae 0.5 ppb at 3 yr
lalaes froa graphs, other data for
17 aornal pregnant eoaen. 20 infants.
tOlTCBLOSIUIIO EIPBEITIS: 1CTBOBI;
IIE6IMCT: JU1B; BIOOD: BILK:
11CTITIOB
latleats vita skin disease cansed by
rice oil contaninated vitk
highly-chlorinated PCBs. Tested 9
ic-1 yr after Intoxication.

laieaa

CItOBIBl OBG11TC COBPOOIDS; EIPHHTL
CCBPOOWDS; foOD COIT1BII1TIOI; CBII1;
Sill DISElSIS; BIOOD
a) Patients - gas ehroaatograa (GC)
patten peculiar to ynsho
b) Patients - GC pattern siailar to
a)
c) Patients - GC patten siailar to
d)
d) controls
significance of similarities not
dlccossed i> English abstract.
lasho patients, nornal controls
JiPii: eioot: BiPHEin cosronws:
fOITCHIOHllTID EIPBEITIS; POPOllTIO*
I1FOSOB!
a) lasho cbildrec
t) Bothers vho coasaaed
ECB-contaaiaated oil
c) Control children.

Exposed aothers. their offspring, and
eentrols la Japan.
Ciarrkea. physical dullness.
ationlnal pain.
fClTCBLOBIHTID EIPBEITLS; BIOOD
CIISBI: JIPII; rooo COITIBTIITIOI;
CBIIDltl
(HIT PIG!)
BETIBE1CE
Knvabara, K.
yakashiji. T.
latenebe, I.
Toshida. S.
Koyaaa, K.
tanita, I.
1979
Bnlletin of
Eavlroanental
Contanination and
Toxicology 21:*58-«62
Kodaaa, B.
Ota, H.
1980
Icchives of
Environaental Health
35(2):9S-100






Chen, P.B.
Gav, J.a.
Wong, c.K.
Chen. C.J.
1990
Bulletin of
Environaental
Contanination and
Toxicology 25:325-329

Basnda, T.
Kagava, B.
ShiaaaaEa, I.
Takada, B.
Karatsnne. B.
197«
raknoka Bedlcal Journal
65(1): 25-27





Jbe, s.
Zaone, y.
Takanatsn, B.
1975
nkaoka Bedical Joaraal
6*(10) -eos-609







-------
       lr  chloro (8 CI)
l.t'-BlphCBTl,  chloro derits (9 CI)
1336-36-3
      coBFosmoi vEinoni OB n»rmEBi»ED
                                                                                     (COITTIOED)

























TISSUE EIPOSIJBE SOOT I alalTIICll BtUIES B»GE HE1B GEBEB1L IBTOBHTIOB I EIIEBXfCI
BETHOD OJ C1SES 1
I
3659 GC a| 82 a) 1-7 ppb a) 3.0 * or - 1.3 ppb a) Controls 1 Takantao. B.
Blood, b) 15 b) 2-15 ppb b) 6.3 » or - 4.0 ppb b) PCB-polsoned patients | I none, I. •
Plasaa t Ibe, S.
EIPBIJH CCBfOUIDS; CB10BHI OBG1IIC I 197*
CCBPOOIDS: Eicon ; BLOOD PLISBI; JJPM I Foknoka nedical Journal
1 65(1):2S-31
1 1 1
1 1 1
3660 1 a) 33
Blood, 1 1 b) 19
alasaa 1 1 c) 30
1 1 d) 1
1 «) 1
1 ft 1



1
1 t
1 1
J
I
1
r
36«1 I BC a) 107
Blood. i b) 151
plasaa 1 c) 166
1 1 d) 192
1 1
1 1
III I
1 1 \
t t t
f 1
I 1
1 1
1
1
1
|
i
3662 1 1 OC
Blood, ( 1
(bole






3663
Blood,
•iole



3«6«
Kidney








































9C




















6








a) 11
b) 25




1










a) fat given a) 6. 1 * or - 3.52 a) Hospital patients | Inooe, T.
b) lot given ppb b) Znciated persona | ibe, 5.
c) Bot given b} S.4 + or - 4.26 e) (bn-enaciated persons | Tafeaiatsu, B.
d) Bot given ppb d) 24 yr old aile »ith aplastic | lofci, ».
e) Bot given c) 4.7 » or - 2.17 aoenia and stoach caacer , mid, s.
f) Bat given ppb e) 73 yr old nale with colon cancer I Fnjivara, It.
d) 92 ppb f) 13 yr old fenal* with Tnsfco I 1975
e) 230 ppb | rakuokn Beflical Journal
f) 5 ppb Japan | 66(10:610-616
EOITCraoBIIlTIB BIP8EBIISJ DDT; I
BEX1CBI080CTCLOHEHBI: 3LOOD PL1SH1; |
BIOPLISSS: JU1B; S1STBOIIIISTIML I
STSIEIf; PESTICIDES; 13IPOSE TISSUE; |
I If IB; KIDEET.S: OBSBTOB f
|
•
a] 0-20.6 pfb a) 0.3 ppb a) Baral blacks r Finklea, J.
b) 0-29.0 ppb b) 1.9 ppb b) Urban blacks | Priester, 1. 1.
c) 0-22*0 cpb c) 2.3 ppb c) Brbaa Caucasians | creason, J. P.
d) 0-16.6 FFb i) 3.1 ppb d) Bnral Caucasians | Banser, T.
1 Biaoers, T.
t | Orban ana rural residents of sc, t Banner, D.I.
1 Infants, children, adults, elderly. I 1972
1 1 Jnerican Journal o*
I SOUTH ClBOLIBl; IBDtTS; CBILDBEB; I Pabllc Bealth
I IKIal STUDIES: BLOOD PLaSBli 1 62 (5» : 6*5-651
| CCBP1SJTITB IT1L01TIOIS; ODD; DCZ; I
I CCT; CIJLDBIB; PESTICIDES; |
1 ECETCB1OBII1T1D EIPHEEILS: UB I
I iciiVTioB; rcoo coiriauiTioH: i



2.2-4.0 ng/nl








) 1-6 ppb
) 1-12 ppb




ot applicable










1 PESTICIDE BI5I9UES: POPDL1TICH )
I IIPOSOBE: BOIU IBEaS; OBB1B 1BI1S 1
1 1
2.9 ng/al I | gorlta, B.
1 1 Obi. 6.
1 Bealthy Japanese, aqes 21-35 yr. I 1*75
I I Environieatal To lint log
I JIEIl: 10IEOSI TISSII: BLOOD; I 6:269-274
| CBLCBOBEIZIBtS; PESTICIOZS; 1
I ECITCHLOBIR1TED BIPBEBHSJ ETBOSPBEBE I
t 1
1 1
a) 2. 8 « or - 1.5 ppb | i) controls | Takasatsu, a.
b) *. 8 » or - 2.9 ppb | b) ECB-poiscwl patients 1 Inane, I.
1 f Ibe, s.
1 EIPBIBTL OOBPOHEDS; CBLOBIBE OPSIITC | 1974
I CCIPODIOS; Biooc: BLOOD PLISBI; Ja?ll I Pokaaka Bedical Journal
1 | 65(1): 21-31
36 ppm (fat basis) I 34 yr old (ale with aplastic aneni* | Inone, T.
1 aid stoaacb cancer I Ibe, S.
1 I Takaaatso. R.
1 Japan | loki, f.
1 1 Biki, 5.
1 tCITCRlOIIIKID tIPBEJTLS: DDT; | Tu1l«ira. K.
| BIIaCBLOlOCTClOBnHI; BIOOC PLISBI; \ 1975
1 lIOfLtSsS: J»»; G»STBOI1TESTI«IL I rukaoka Heiical Journal
I £1J1»8; fSSTICIBSS: UIVOSS 11 S SOT; | SI (10s« W-616
t mis: nmis; OBHTUS \
1 >
                                                                                                                                                                                          Ul
                                                                                                                                                                                          ro
-------
Eipbenrl, ehloro (8 CI)
I.I'-Blpaeiyl,  eklaro derivs  (9 CI)
U3C-3C-3
tiici COIPOSITIOI imtxNi os
                                                                                   (CORII0ED1
HSSfll

3« 9





















a









MUSS

lot applicable









«) lot given
b) lot given
c) lot given
4) lot given






a) lot ilven
b) lot given
c) lot given
d) lot given





















<0.0*-0.1 ppl








inn
Hit

TO ppa, fat basis









a) 612.5 ppb
b) 680.0 ppb
c) «82,5 ppb
d) 5)0.0 ppb
Fat basis





a) 2» * or - 9 vg/kg
b) 2» » or - 9 ilf/tg
o) 29 » or - 8 ag/kg
fl) 19 * or - « 19/kf





















0.05 ppa








P1GE)
GIltUL IirOEBaTIOl

2« TE old tale «ith aplastle >•«•!&
tti stesaea cancec

J*p»

ICltCBLOSJiniD nPHCTTLS; BDT;
DiiiciLOBocictoEnaiE: BLOOI Piisaa;
izociisia; 4ipi«; O«SISOI»TISTIUI.
3TSIE5; PESTICIDIS; IDJSOSI HS3HJ;
tiTtB; Kitiiis; CHITHI!
i) 1 wntk
b) 2 laithl
c} 5 loathe
41 T untie
Uter pactnltlon i« 19T3. Estlcated
ftea qcapk.
lecul, pceqiant «ose> In Japan.
ECtTCILOIIIllfO EIPBWTIS; lIBBCBi;
CItCIllCT; JIP11; BtOOD; VOX'.
IICTITIOV
•> Oslo, Ittge iBdistrlillxci city
1) lerqea, large IndastrlallxeA city
c) latstal. JMllit cltr >ltk lar?«
ch«ilc«Vp«troclie»ical coatl«r
4) foraifrnnB, non'ln4astclallzea
(iailiq cotatnit;
1576 »act«7. si quit leant Increase (P
< O.OS) In Oilo, Bergen, and Barsta4
eaaplat e««pared to a 1969/70 s«Tey.
lemqlan aethers, ages 2S-2S yr.
ItlPOSB TISSUE; BHX; COHPIIITITE
IllLUlttOlS; IOBB1T: tBOtTS;
IOTCPSIBS; ItlBOBR: DOT; CEtCBISlTEB
ETESOClBSORS; PESTICIDES;
ECITCEI01II1TID miEITLS
t«Tin of bleloqical inpact of PCBs
en breast-fed infants and
r«coai«nattions far nrstnq nothers

J1P1I; IBNTS; IinnS; SKIi
I1SE1SES; RIIK; BtflCT;
ECtTBIOIIllTID BIPSIiTLS;
ECITCHtOIIIlItD BIPBMTLS;
EI01CCHBVl*IIO1l; nRE EETISDlRIS;
fCCE CORJBIIHIOf: TOOOS; HCTITIOH;
tCPQUTIOI IIPOSOE!
8iab«st 2 levels In boose* lies «ho
bad navec lived ostsiie Colcrada.

H-2« yz olds In 2 Colorado
eonniaUles vitn popolatlona of about
•5,000, prisarlly aqrlcaltacal, ligtt
irdnstcr.

CCLOB1BO: 1EI1TS; IULK;
EOIICB!.OB1«»T!D EIPHHTLS: KVOLHIOI
IIPOSV1E; BOIU HX»S
_

SEfEBEIC!

Inoae, T.
»be, s.
TakaMtsn, a.
aoki, ».
Riki, s.
rnjivar*. K.
1975
raknoka Radical Journal
66(10:610-616

Kodaaa, R*
Ota, R.
1980
Irchives of
EnvlcanneDtal Health
35(21:95-100




trevlk, I.H.
Bjeck, J.E.
1976
let a PnarMcologica at
Toxicologica
«3(1):59-«3









Biller, S.I.
Tinberg. L.
1977
Journal of Pediatrics
90 (3): 5 10-512






Savage, E.P.
Tessari, J.D.
Ralber?, 3.9.
Vheeler, H. v.
1973
Bulletin of
Environmental
ContHiaation and
Toiicology 9(«):222-22S


                                                                                                                                                                                        Ln
                                                                                                                                                                                        OJ
-------
ti;k«BTl. chloro (B CI)
1,1>-Bipk««Tl, chloro aarlTS (9 CI]
133S-36-3
tiler coiposmoi vinoi* OB OHSTIBRHSD



















TJSSII

3670
Bilk









3671
Rillc,
yhole


ZIPOSDE! SOUIB












Inaestioa



[
1
1IUTTICIL
HETBOD
GC










SC-IC

ICSBJS i Hies »"i
OF CUSS 1
1
1.057 a) tnce-S.100 ppa a| 1. «96 ppa
b) 0-< 1 ppa b) Rot airea
c) 1-< 2 ppa c) wot giTen
it 2-< 3 pp* 1» »ot 9i*e«
ej > 3 ppa I e| got giisn
Fat *t bacl* 1 rat »t basis
f
1
I
|
f
a) 0.01-0.10 ppa a) 0.032 * or - 0.019
b) lot gif«n ppa
eitmi i»ro«HTic»

a) Total. 1»77-117«
b) 27t it saiplaa
c) «9.5« of saaples
91 17. « at eaaples
ej 6. It of aaaples

Besideots of llcUoM

IICBIC1II; JDDHS; BlUt;
EOHCHl SIPBIHILS; IMIII
BIXIBES; I»DOSTBHl IB BIS
a) 1972. Ht saaples
bl 1973, 123 aaailes
c) lot «i«a bl 0.038 » or - 0.025 1 c) 19TI. tit saaFles
I dj 0.01-0.1* ppa ft* 1 A) "75. 113 saapl«s
| •) 0.01-0.10 ppm c) O.o»0 * or - 0.026 1 «) 1976, 100 samples
| t) 0.01-0. 2« ppa ppa 1 *1 1977, 101 saaples
1









1
t
3S72 | I a) 1 a] lot applicable
0 Kit «l I I b) 1 b} lot applicable

1




1
1 1
, I 	
i) 0.036 • or - 0.023 I !«»«!« kii?k«st In 1st parity aothers.
PP« 1
e| 0.033 * or - 0.017 I 100-141 lactatlag »oaeo. 2 aontks
ppa I after dellTery. Residents of Osaka
f) 0.039 * or - 0.02 I Prefecture, Japan, varied diets aal
ppa 1 CBTlroaaeotal coadltloas.
1
I JIF»: ticiinoi: BLOOD; HII.K:
1 tioiccniiJiiTic»: PISTICIDES;
| FCIICILOHIJITID EIBBHTLS; OS611IC
I CBIOBIIE cosponicts
|
a) 1»0 ppa (Cat 1 a) 73 ji old aal« rlth coloa caacec
BIKBEBCE

Sicklier, T.H.
Bcilliant, l.B.
copaland, fi.
tildea, t.
1981
taericaa Journal of
Public Bealtb
71(21:132-137



Takasbiji, T.
tatanabe, I.
Kvvabara, K.
Tosblda, s.
Korana, K.

















Ktmita, 1.
1979
International Ircaires
of Occupational and
EnTlronMntal Health
«3:1-1S





1
1 in
luone, I. **
basis) I b) <6 rr olJ sale »ith atoaach cancer Ibe, s.
b) >. 1 ppa (fat 1 Takaaatsu, I.
basis] 1 Japan lokl, ».
1 Rlkl, S.
1 FOIICBLOIIIIIID EIPBEITIS: Oil; Fo1i»sra, K.
1 BmcHtoiocTcioHHiiB: BIOOB PLISSI; 1975
1 HOPtlSIS; J1»I; GasnoinZSTIUL Fnkaoka Hedlcal Joaraal
1 STSTU; PESTICIDES; UIPOSZ TISSOJ; e6(10:610-C1«
I tiTra: IIDIIIS; OSEITUI
	 1 	
-------
Cocoa
7MO-I2-I
I
It! 10.11.  U 2200 C (approz), BP 2550 C, TP «.5SItO(E-S) atl «t  21*0 C,  1  u «« at 2664 C. 10 u Hg at 3030 C
1ISS1E
2C73
laic



















EitosTin IOCTB





















11U.TTIC1L
BETBCD





















BOBBER
or cuss





















mei





















»»i





















CEIEB1L IIFOlBaTIOB
1 revle* of world 11 tent arc OB tke
aeeiBBlatiei anl blocoacentratiOB of
aaleetei toxic trace aetala IB tuaa
laic aid aalli anl otaer aaaialiaa
kiir. ««r, aallB, cla»« and boots*
tabulated IT qoo^capUe ir«a.
iibjccts. svi. a««, exposure
fiall«at( a«lTa«s In ppi, and
aithorltr Icca over »80 rafcnaces.
iftict: tBSfitiia: CHID*; craTiu
IIIKCl; EOROIB; SIDtlE HStj III
iiauiD: soon unica: sonmsi
1SI1; VIITtD nUCBOi; HITtB STHIS;
IIII; I1IL3; BITICT; IITIBOII;
KSE1IC; E01CI; CIDBTU1; CBI08IOB:
cciiit; coppsi; mo; HiBcnsi:
IICIEL: SEtziiOB; Til; TIUDIOH; IIB
Ectinnoi: mini. POPOL»TIC«S;
HOlCCmOHTIOI; BTOIIDIC1TOIS: LUC
icitotioi; tcroimot sxvosati; BITES
iciinnoi; tnci BIEIIBTS; mils
IBIEBEHCS
Jankiaa, D.».
W79
BS»-600/»-79-0»9. 18»
ft-

















tlOliB*
 it
 IVI •>«.*««, B» -1.2J C,  BP S9.*T C. TP 1 BB 9g at -60 C, 10 BB tg at -30 C
tissoi
3«7*
Ereatk
-
367S
lair


SltOSOEE BOVTt
iBBBlatlOB




lUimcil
BRBOD
Pill




OF CaSSS
	
1




B1EGI
»0-0.01 Bf/CB B



-
BEaB
lot glT«a




GiiEttL iircmixoj
-
lltar aatosotive Pb kaltde aeroaol
•iposare. Level* a {auction of
{article Bin. Extlaated fro* qraph.
lllal Taliae of eboet 900 ca a aad
reaplratorT EreqaeacT of 15
CTclec/ala aaiatalaad dnrlag 10-Bia
• aipllag tin.
ISIJIH: BBOBME; C1LCIDB; CBUBIfB:
I HI; lITORami; 11ROSPBHE:
tlBIICOUTES
9«fle». 2* leprcseatatln
pre-aBalTala treataants are
tabilated. IBB (•uibllltT of a
holistic, io-*aBli policy for aalr
imljtls li ntliaed and a«pport«d.
iifiEi; Ti»ci Eiinns: HUB:
IISTSIIII: BElSnSBeBT IETBOOS;
CtTILS: EBOTEIBS; CORPMATITE
ivuntiois; itonioi!: IBTIBOBI;
IISIBIC; BUIOfl; BBOBIBE; ClOHIIg;
ciicuji: CBICEIII: cnoHioi; coaiti:
CCPPEI: SIUIQII; GBSHlItDB; SOI.B;
ic ens: iso»: niTHimn; L;IC;
tetiB9nv«; BICIIL; PBOSPBOBOS;
ICTISSIOT; SUBIBinH; 3ELEBIOB;
JIIIC01: SHIgg; SOBKId: SlaCHTIOS;
sitfBB: TIB: TnaniR; TVISSTEB;
tiBt: mceiim
KnUfCE
p«Baedeie«r< 6.e.
VlBchester. J. V.
EBtrlroBBeBtal scleace
aad Tecbaology
9(101:971-972

Calttleboroegh, C.
1990
Science of the Total
EaTlroBBeat 1*: 53-75


                                                                                                                                                                                             (Ji
                                                                                                                                                                                             Ul
                                                                                       (BEIT
-------
      Eroalne
      7726-95-S
      II
      lt» 79.904,  S3 -7.25 C,  BP 59.47 C, TP 1 » 9g at -60 C.  10  M Eg at -30 C
IXSSII

3676
Hair










ZIPOSOB1 ROOTI













tULTTIClt
RETBGD

11











1 a us BEE
{ OF C1SZ5

«) «
b) «0







|
I
1
| B1IGE
1
1
1
a) 0.7-93. 1 ag/o
b) 0.3-273.2 ag/g










BB»I

a) 1.6 «g/g
b) 5.0 ng/g
•eiians









GIIEEJL HFOBB1TI01

i) Coat DO Is
B) Saltlple sclerosis patints
Sllples ten 7 scalp sites in each
tatjfct.

C1K1D1; IIIOITS; CEHIBil HEETOIIS
STSTF.H oisEisES; a»is: ILOBIIOH:
EtOnllt; CIICIUB; CB10BIJTI; CO?PEB:
ccic: loom: imsiWBSE; BBTILS:
SfLErlVf: SIITKB; SOOIOS; S\JlPffB:
finiiun: ri ic

ES/BBEBCB

Byao, D.I.
Bolzbecher^ J.
Stuart, I.e.
1978
Clinical cha.lstri
2»(11) : 19*6-2000






    fataM
    1C6-97-8
    C'-BIO
    II :».12, BP -138.35 C.  SP -0.5 C. TP 2 at. at 18.9 C
f IISSUK | KIPOSV1E 80DTE | 1I1LTTIC1L | IOSB5E | B1I5B
1 I | SPTHOD | OF CASES I
II 1 II
II 1 II
1 3677 | I CC/BS |8 I lot detect«d-9.» ug/ir
f Ereatl f 1
1
I
1
1
I
I






1 1
1 1
1 1
1 1
1 1











1 I 1
(
1
1
1
1
1
/












I III! I GEIJilL MFOBHITICJ
1 1

3.9 ag/hc














Ceipent related to notial
letabolis*. lo other detail! giren
Ctrcgenlc saapling technique.

Realthr lilltarr and cirlllan
eiplorees, D.s. tic Force School of
Krospaec Seticiae, ages 23-47 ji. 3
e tot«rs.

eilTHES; CBICBIMtTED HTDBCClBBCIS ;
CB10SII! OIC11IC COKPOOfDS:
CI10BOB!»EIIS: FL3CBISE COKPOIHUS;
JBtlTB; EICCBOLS; TEI1S; 1C01TS

BEIESZBCE

cenkle, J.P.
Ca.p, B.j.
Velch. B.E.
1975
IrchiTes of
FDTironrectal Health
30(21:290-295







      alcohol  (8 ct)
         l  f9 CI)
71-36-3
C«-»io-O
81 7«. 12. SP 117.5 C. TP 5 ••  Bo.  at 20 C
1 IISSM
1
1
1 3678
Breath


zirosoBi soaiz



1 t IUTTJCJI
HETHCO
oc/as


insta
or cisss
a


tues
lot oetected-35.0 ag/hr

(»n
mil
'.1 ««/hr

HUl)
GfHMI IIFOIUTIOI
ccifotad related to aortal
Mtabollsi. lo other details give*
Cryogenic itmllmq t«ctniga«.
Baalthr ailitary and ciTilian
etployaes, D.s. lir Force School of
Ictospace e, aoes 23-*7 yr. 3
linkers.
tilings; CltOIIIHID BTD8CC1SBCSS;
cncim OBSHIC CORPOVIBS;
cncBOBiiznts; r»ctt» COIPOBIBS:
fiiiti; iicctoLS; tuts; icntts

EBFEBEBCE
Coakle, J.P.
Caap* B.J.
Reich, B.t.
1975
Icchives of
CnrlroaaeDtai Health
30 (2>: 2*0-295


-------
Iitrl alcokel (8 CD
1-8«taaol (9 CI)
71-36-3
ca-no-o
II 71.12,  BP 117.5  C.  TP  5  » I« at  20 C
                                                                                     (COETII3ED)
TISSUE
3C79
Breatk












EiMsrai tovn














iBiiTticit
8ETBOD
SC-HS













•mast
or cisss
5* (387
saaples)












S1ME
lot gira














1.» ng/1
Geoaetric












GZBZMI ifrosaiTioE
Beamed at 25 C aad 7(0 aa Bg
36.2* occurrence
lover aad upper one-sigaa Halts 0. *1
and «. 8 nq/1

flea-lthy, 18-35 yr old, nonsaoking.
at tan blacks aad caacasiaas.
Chicago, 11. Bigldly controlled
experiaental conditions.
EBIHB; 1 ICC SOLS; I1LIMIS; 1DU11S!
CB10BII1TZ1 BIDBOC1BB01S: lOllTILB
CIGIITC coipcmis: RZILTB B»?IBDS:
1IB1111ICI; BE11E01ISB; BITIEOLITIS;
ICJH11TIOI 1IPOS8BE; UBB1I 1BE1S
lErEBESCf
Krotosz]nski, B.I.
Braaean, G.8.
O'leill, H.J.
1979
Jonraal of Jnalytical
Toxicology 3:225-23*








Cidaiaa
 ca
 Itl  112. M. 8? 321 C, BP 765 C, TP  1 aa Bq at 39» C. 10 •• Bg at «86
1ISSV!

3680
lerta
















3681
Blood







EIPOSOBE BOOTE



















Inhalation








iiiimcu.
nTTBOD
•1

















115








IDHBSB
or cisss
3


























I1IGE

Bone detected

















0.7-3.8 ng/1








BEII

lone detected

















1.5 og/1








6EIIB1I. IBrOSBlTIOl

Bales

Pcoa a groap oC 61 autopsies.
fetensic aedical •xaaiaations, Japan.
Bales, aeaa age «0. « yr. resales.
•eaa age 37.4 yr.

TBICE ILEBEITS; IBTOfSIBS: J1P1B;
•mains; IBSCTIC: CISBTOR; COBILT;
CBBOnnB: CCfPIB; IBOI; HIICOEI:
iigiDB: BieiisivR; BIBCMZSB;
HtlDHJl; 1IIIBOII; SClIOinB;
StlEIIIB; TI11IID!!: T1B1DIOB; ZIK;
ECLO: BBOBIIt; LIVES; KIDIETS:
CIBIBBDB; CIBEBE1LOB; HS»BT; BDSCLES;
EIICBEIS; SE1BEI; LOIGS; 1OBT1;
ICT1LS: COBP1B1TITE ET1L01TIOVS; SIX;
rCBHSIC HECICIIZ
12 saaples
Direct detettiaatioa and extraction
ctocednes agree.

Iclders, garage personnel aad patty
•crkers in Svedish airplane factory.
.
I1DOST«I11 PCLLnTIOI; COBPlBlTIfE
iTiioinois; ciDBiDB; SVEDZI; icms;
EIOCD; US HI; BI01CC050L1TIOB
BZrEBERCE

Tnkava, a.
Svzaki-Tasnaoto, B.
laano, K.
Terai, B.
1950
IrchiTes of
ZnTironaental Bealta
35(1) : 3(-*a










Lagesson, T.
Indrasko, I.
1979
Clinical cheaistry
25(11) : 1948-1953




                                                                                      («EII P1GE)
-------
Cadalta
Cd
»t» 112. ««. It 331 c. SP 7SS C, TP t •* »J 
1 I aaaa for a»d anflraaaantal afraeta of 1 Tolpa. s.
1 1 Cd, as rapactad tr tM lataraatlaaal 1 1979
< I laat tine Orqaoiratlon. I Cadalaa Basaarct Diqas
1 1 1 lo. 1, 24 J>P.
I j I smn: CUB ma: anus; iMsoBmn i
f 1 1 SttJOBSj II fITO llHTSISi BtOOD; (
r 1 I OBIII! EIDItl BISHSJS; SOIB 1
I i I cisusts; cccorartoiii Distisxs; i
i i I fcmiixoi inosiTBE: IIOITSTIUI. t
1 1 I fCUOItOI |
1 1 1 1
III t 1
J«» I Iijaatlot | a) M 1 a) lot atiata a? 0. IS >g/IOO al 1 al JOT* Itrlag < t It* from aaaltar | Bucks* , 3.r.
Mood | laialatloa b} 20 1 b) lot gli«a b| 0. IS aj/'OO §1 I b| elcl* liilas < 1 ka team aaelte? 1 Boala, a.
t
|
1
1
1
f
f
1
1
1
1
1
I




3695
alaod










3««C
Hoot





^




c) »0 t c) lot gl*aa c) 4.11 og/100 tl I c) Cklldraa at 2.5 ka froa aaaltar 1 laiaar^a, 1.
d) 19 | d| »ot jiraa 4) 4.1 ag/100 al I d| sroaa bof* | traaax, p.
at 1 | al art ftr«a a) O.W ag/100 al 1 a| Irbaa airla t cla«Ts-Thgc«»o, r.


1
1
1
1
















* »


































\

i) «J If) lot fl*a«













a) 70
b) «0































a) 0.02-t. »5 »9/10J al
ft) 0.05-9.SS ag/100 al










.3-29.0 «g/l







\
f> 0.08 at/100 al | n laral ekildraa | lafoatalaa, L.
aaitlaaB 1 latiaatai fcoa qrapk | Terdafa, 6.
f | 1980
f seiool-age ekildrao Urlng tear Pb I CBTfcoaaeatal Ba«ir-6
I caaltar in 8«lgi». Controls froa I 22:95-108
1 oral aaO trtau araaa. |
1 «
t uieatiss: c»m«: ustnc; issraic i
| Ciffinc CO»PCB>BS.- CBUBBIl; |
J IBttSIlUt IIBOSPHHIS; StttllXS; |
I IITltS; ILDCC: OEHJ; BZLGNB: 1
I »c;niTioi inosBti; mil iai»s: f
I oBfii tins i
i i
I i
at 4.12 « or - C.01 | a} ceatroli | lawarrs. s.
ag/100 al | t| tasljaet* of foil (tad arag I Joels, a.
BJ 0.1« * or - O.«1 | | taraard. i.
•7/109 al | Icaaa, aaaa ag« 82.3 rr, fr»a I laekat, J.P.
(S.I. 1 | C4-«ollata4 ataa Kiaqe) , aad 1 1989
1 central*, aaaa aaa «1.1 rt. froa t Iota national IrcalTea
I Ctaclarol. lalglaa. I of Oocapatloaal aad
1 t tMicoaaaatal Raaltk
I 1100B; BIOOO niSU: UHIIS: ClBariS; I 15:2T1-2T*
r tilt: XNCD31] 1IK; ICIilS; SBtGIOB; (
t isi; porvtuioi nrosvu; mismu i
I fcLtirios; stntns: MDIEI nsiisss i
i i
lot 9l*a» | cccaaatloaallT alpotad (-39 IT- lo 1 lblgi«o. I.
I ctkat 4at«ll( ql»a. | «attaa«a, S.
t 1 W»t
1 33-»» TC olta. Sta&aa 1 fhialca la BadiciM a»l
1 1 Jlolaji J6(1):1?-2S
\ »tnt«: Bioct: xinnsi ntint n t
l IIIQ i*»VTJtsi tBismiatn >nao»s; I
I cxiramt occOTVtiotn wtmj: sniis \
	 I 	 \ 	
































Ul
CO






































-------
Cadaiaa
7«ao-*l-e
et
lt« 1t2. «0, BP 321 C. B? 76S C. V? 1 H Bfl at 39* C, 10 u Rg It »8S
                                                                                      (COBTXBIED)
IXSSBt

3C87
Blood.
plasia













3688
Blood.
sens



















3689
Blood.
aan*



















BHOSVSE Bone

Inkalatloa
























































ABAlRICAl
BBTBOD
US



































US




















	 iBBBSB 	
or CASES
•) 60
b» »5
e) 70



































a) 260
b| 260




















EAESS

a) O.OS-O.S5 ag/100 al
b) 0.01-0.28 ng/100 Bl
c) 0.02-0. IS ag/100 el



































a) lot 9i»e»
b) Bet «i»«n



















(BER
ISAB

a) 0.13 B9/100 Bl
b} O.Oa B9/100 Bl
e) 0.10 ag/100 Bl
Geonetrlc


































a) 16.* « or - 6.3
ag/1
b) 1.2 * or - 1.1
a 4/1-

















PAGE)
CIlMAt IEFORHATIOI

at Iesid««t» of Liege (aoit collated
area)
t) Besideats of Brussels (less
foliated aceal
ct tesileata of Charlerol (eentrol
atea)
lleea residents differed fros
Charlerol (p<0.01) aad froi Braisels
-------
CatllU
Cd
ttl 111.10, BP  321 C.  BP 7«5 C, TP  1 a* Hg at  39* C. 10 n 19 at «86
                                                                                        fcomiota)


f
IISSII
BOW
3691
Brail
xtroscm IOBTB


Bair
1
1
693
ale

aiiimcti
us
it
- -
it
i
i
'vasts
or ctsi
i

1 US a| 31
b] 22
1
1
1
f
1
t

tuet
t3 tot ippiictblt
b) tot applicable
c) lot applicable
1) lot applicable
a) (one detected
b} low detected
c) lone detected
d) lone detected
•iii i Gimti nnnmo* ismsacs
l
i
if 8.3 fs* l tt Spiae, aeanred tr US Slaiier. J-»-
b} 2fi * or - 13 ppe I tl Spiae* aeasured *y It ldiaar B.C.
c) 3.2 ppa | c| lib, aeatored by US Bce«er, 9.9.
11 2.1 ppa | 4] renr. leanred IT US Barrey, T.C.
1 1*80
I Ktopaf ip*eia»a». Bittetrj plate Illtiai Joina.1 of
1 aaker, aorted iltk Cd foe 3« 1C. Icdsttrial Seilcioe
1 37.-278-2M
I fOIR; KIC1ZTS; IITIB: IBTCISIJS;
l ciDni*; aniLs; occratiiottt
I BmtDS; OIIIJD niGDOR; OCCOPHIOIll
l [isiisis; aim i
1 1
a| noae detected I a] Riles, cerebtaa, t nblectE I Tifcaia, B.
b( loae detected | t) Feialas, cerebn*. • nbjects t SnaU-Tansota. B.
c| gone detected I cl Bales, eecebellw, ( nkjects I taaao, K.
d) loae detected I 41 leeales, cerebellns, 4 lafcjecta 1 Tetai, 1.
1 | 1380
I tioi a gtoaf of Cl aatopcles. I Icehires of
1 (oceulc eedicel exasiaatlOM, Japaa. | laflrowental Vealtb
I Bal«, eeu a«e tO.S rt. leaales, I 35(1) : 36-«(
1 ieaa aae 37.1 rr. I
1 1
1 tsict ttEtitrs: iiropsrss: JIFH.- i
i juranui1; nstxtct ctasnas cososi i
i CVlCBIQf; CC£PEB; IBOlI 91KCCBI; F
1 iriru; nieitsite; nisiaist: i
j meiom; iiiifloiT; scamof: 4
I SfLIBItl; TtlltHTK; MltDIta; ZIK; I
1 «CIt: BOTBIf!: IiriB; BIDUIS; |
1 cntnm; ciBSEiittia; BUST; BOSCIES; i
l Tjirnis; srrinr; IIBSE; taiti i
I BITIL3; COaPlBtlirg irilOlTlOIS; SIX; I
I tctiisic gieicm i
1
lot qirti a) 1.72 pp« a) tea.nli« JisafcUd | P16I, F.O.
lot gireg b) 1.08 ppa t) Controls t Parlies, '1.
I 1»T7
l«ani>4 disabled tad norsal 3rd and I Selene*
atb grade stideats i* Caaada. I 19S(«3I3) t2M-2O«
I CIICI01; RteilSIII; POI1SSID*; |
l i scriM; ciEHina; costif; cotnsi: i
I ItOl: HID; MIGaltSt; ZI1C; I
I ctROKina: ixtflMit amcnst: anus; t
t 1(11; CSIXJBfl: Clltlt |
1 1

1 t
J leTiev* 21 repcesentatiTe | CBittleboroff^h^ <*•
1 pce-aaal?sis tr«ata»nta are | 19S9
1 tatalated. Tie Ceaslbilltf tl a j science of the Total
1 kcllstie, BO-nsb pollcr fot kaic I Emlconaeit »:53>75
1 laalysls i» ovtliied and supported. 1
t tiiin; TBtct titmns; snt: I
1 IUSTSH.H; BftSffiraiBT BITEOCS; |
l itiusi tRcitits; ccatuitin t
l mumais: UOBUCB; tinscn: i
I llSItK; BlllOa; BBOBtM; C1CJIOB; f
I ciicns; ciLCiiiz: caiosina; conn; i
l ccppti: siiuoi); BitBuinB; coit: i
1 ICDIll: MCI; LimiJUB; lilt: |
i iiensnn; Biiemsi; BSBCDM; i
I ECITBDI11H; IICK1I.; PSOSPHCBnS; t
l tcussiii; minim ; SILIIIOB: i
I E11ICOI; SILTES: SOIIUB; SIlCITlnB; 1
1 SVITm: Til; TITtlllfl; T01GSTII; I
I 1I1C; IHCOHD1 |
1 1
(IE1T FUSE)
-------
Cadlloa
7«fl-«3-*
Cd
»ti 112. M. BP 321 C. BP 76S  C,  VP 1 si Eg at 39* C. 10  »  19 at *8t
                                                                                        (COITIItlED)
ixsstz

369*
Hair






,„,
Bale













3««
Balr



















3*97
Beart














EEPOSVR BOJTB





























































1IILTTICU | IDBBSB
•EMOB
»CT







n



































ii















OF USES
1







a) »
b) 7
0 11
4) TO
e) 10































a) 10
i) »














UMZ

0.66-3. ea 19/9







a) lot given
b) lot glten
c) lot gl!








CIEIT P»GZ(
-------
CaJalta

7«ao-«-9


Itl 112.10. IF 321 C. SP 765 C,  TF 1 »a Bo at 39» c,  10 aa  Ra. at MC
                                                                                 (COItKOEB)


TISS3I
3698
XUa*T
3699
THaar (
I
1
t
3 no
ii4a*r
mason ton


i
i
aBumcu
BATBtJA
US
M
US
1
1
nriMti i met
OF C1SSS |
1
1 a) lot tint
1 ii lot «irw
1 c) Bot giro
1 A) lot glm
1 •) 5S1-1B9I pp.
1 t) 833-939 pp.
I g| 200D-4000 ppa
I t) 1230-2850 ppa
I lit «t
1
1
1
1
1
1
t
i
t
I
- - 1
•) 19 1*1 5.6-110 ag/9 (wt «(
b) 3 | b] 5«-«T aa/g (Mt at)
1
1
1
J
1
1
1
1
1
1
1
4
1 1
1 1
1 1
1 I
$ J a> 1.67-13.1 ag/»
J | b] 2.3V-37.2 «J/T
12 | CJ 0.503-27.6 aj/j
1 let rt
1
1
I
1
t
1
1
1
1
1
1
1
I
r
t
i
BUI i eiieiu monunoB i nnmcs
i i
i i
t i
a) 3231 ppi ( (I 17 caaear patiaats | Baaacc, O.I.
b) 20«1 pp> | t| 58 BOS-C«DC«C p»ti«at« | caloccl, l.Y.
c| 1188 ppi | c| 1ft Kttaiotecs (a«nr a«at«a) I lasaalUjia, T.
it »« ppa | a) 5 laokara, 1.5 packs/oar 1 Illllaaa. Jt.I.
•) 1221 ppi | *) 2 »al»s, «9«a 10-11 71 1 Ftakaclon. C.
t) »fl1 ppi | f| j «» 2197 pp« 1 M • (aaal«a. a««a 50-59 re 1 S.JiclB* 1S(12) :95«-9«3
ask »t | |
I Ktcpatva ftaa hospitals la forth ud I
1 feath Carolina. Marts and I
1 caecaatui. Halt*, *q*M 16-91 »r. I
1 Calldiaa, «i«a I al*a I Tnka*a, B.
(«*t it) ) t) Taaalaa I SaziU-Taavaota, B.
>| «0 + or - 6.7 ag/q 1 1 taano, K.
;«st «t) | ma a 7roof of 61 avtopalas, I T«ra.i, E.
( tcxa»ic mtitctl enainatioas, Japan. I 1980
1 >al*a, aaan aaa 40. 6 rr. f«aalaa< I Jrctl»e» of
1 aaaa aq« 37.1 TT. I EaTiroaMatal B«alth
1 1 35(t|:3C-«*
I nice KS8ZIH: tmotsisss JJP»I; t
1 iKmim: tissue: cjnaiirs; COBW.I: i
l cnomas: const; icot; BEBCMT; i
1 iititrB: BiGitsios: iineuisi: i
1 IBSICIOH: IITIBCIT; SC»»DI05; 1
1 sitnimt tiiiiios; TjHBiijjt UK: i
l eciB: Bfanic ixrn: KISMTS; i
i cisiMia: CIIEBIUOI: n»»; HOSCIBS; i
l incBiis; svixn; niesi tcni: i
( tttltSs COSFIMTln UTU.D1TIOKS; SIX; I
r roiifsic RICKIK i
i t
i r
a) 2.< o oroof II. 1
t Ceatrol*, aon «3-72 yr. «ao llwd SO 1
1 la fraa tb* factorr- Sawdai. I
1 1
l siiDEf: CIHTISS; tnttrsi LITEI; i
1 It IBS; CODUmlTK IIStOlTIOIS; I
i iicvsniii Bieizis: nisaiiBin i
1 KTBOB5: JITIBOrr; IBS MIC: CWIXVB; I
l cismi: c BIO ting; CCMIT: coteii; t
1 eets; I8O«; IIITUIDB: L»D: (
I iJieiBisi; BISCUIT: BDITBEIIDR: i
| EMSFROtOS; SBBIDID1: SCllIIOB; |
1 MI Hi-ii; sum; TI>: raiesnf: i
l me: win niuas; notismti i
1 fiirrs; sBtneis; TEWIIIHB i
i . : i
(ini notj
                                                                                                                                                                                 o>
                                                                                                                                                                                 ro
-------
Cadslui
7UO-B3-9
ca
111 112.40.
            IP 321 C, B? 765 C. TP 1 aa Bg at 3M C. 10 •• Hg at «86
                                                                                      fCOITIinBD)
TISSUE

3701
lidaer










3702
XidBay













3703
Kidney









370*
Kidney







IXMSOn BOBTI




























Inoestion



















1IUTTICU
aZTIOD
US
11










I*


































IUHBEB
or cisss
1











a| 19
b) 7
cl 11
d) 10
•1 10






























BUGS

a) let applicable
b) lot applicable










a) lot given
b) lot given
c) lot given
d) lot given
•) (Ot given






























III)

a) 77 ppa
b) SO » or - 20 ppt










a) 0.07 * or - 0.06
ft*
b) 13.33 » or - 22.72
PP>
o) 8.57 * or - 3.97
ppa
d) 2*. 10 » or - ia.10
ppa
e) 20.89 « or - 12.26
ppm
let *t
























GEimi iirosBitioi

a) Measured IT IIS
t) Beasured by It

latopsy speciaeBS. Batter? plate
•alter, vorted «ith C4 for 3« Tt.

Cateoaalacia. reaal tabular
disfaictioi
tens; KIDII1S; LIT IB: ITCCESXIS;
citBMB; BitiLS; occo?iTto»li
BIHBDS: uinsD nisDOH; ocajpinosiL
ciszisis; mm
a) Ibortases
b) »9«a 2-5 ir
c) Iges 13-11 rr
d) Iges 25-3* TC
<) loe* 65* jr
late also aivea br race a«d
occupation.

Igtopaiea of accitental deatlis in
Ckio, ages. <1 ao-qteatec thao 65 ji.
aid abortuses.
mils: OOBIDI: HUE; KIDIIIS;
iitn; ttttofsns; smnis: icstccos;
1«I; FOPOUTIOI BIPOSBBB: 1BDITS;
itotEscsns; CHiiDBii; runs; OHIO
t«
-------
Ct
»t» 112.10. tt 321 C.  >P 7*S C. T* 1 » B? at 39» C, 10 n H? tt 186

IISSVX | JIPOS1JBB ROOM <»JITTIC»I inaljn | )»GX
I BBTBOO or CJSSS |
3795
KUMT
3106
Xidoer
3T07
Kldn.T
3708
ii fear
f
Inialatlot
1
1


1
1

m
May
Sp*ctroMtcT

»
it i3
b) 10
s

»0t «iT«»
0*9*57 ig
c.»-ii.8 ag
1*3 4C* ttolcal tt acute |
I (caiaoDitif. 1
1 1
I BHIH nieici: IIDHTS: ijfis: i
I lines; trtiH: stii-j BJUBDJ; IRU. i
I rciscwirs; HDVSIIIII itaostmis: i
f HRiiiTiei: cocnp»Tiofu nzuas; i
I cicaMi; SIT t is: inropsirs i
l i
a) I5.J * or - 2.) a? a) forkari, cd ptocaosinq plant < fllla, I.J.
i) 3.7 * or - 2.9 19 t) Cottrola | Bocqu. l.D.
Woaatcie | zanzt, I.
Baag* at critical l»r*la for I Tasaaara^ S.
Ca-l*docc4 titular »cat«iaarta 1 Tarts*;, 9.
•atlaatad at 150-304 tg/1. | Cot*, 5.B.
1 1*81
ItntTS; IIDin DISMS3S; noOTS; 1 Jooraal of Toilcoio^r
tlfSB; IT 1TTO 1IU.TSIS; cigilDB; I ««J InrircBaBntil
(KUST OCCOPJtTIOIU H1318DS 1 Malth 7:491-703
1
lot glT« Talves foe cort«i. Occupitiooallr I Jltlgrai, 1.
eiTOMi S-30 ic. (a atkcc details 1 Battssoa, S.
9i»ai. | 1981
I Pifalcs li S«4iciM tal
33-M TT oUj, Sndn | Biolofly 26(1):1«-2«
1
j coirs ; BICCC; ITIDIITS: mm: Tt i
fltO UaLTSIS: BMSOEERIt BIT HOBS; I
CIEtlOR; OCCOfHXOBU. BlUBDSi BTTiLS I
1
(«trt MGE)
-------
CadliBI
7»4»-43-9
ca
lt« 112.40. IP 321 C.  BP 765 C. TP 1 •• Bg it 394 C, 10 n Bg it *86
                                                                                      (COITIIDBD)
1ISSDI

3709
ll»«














3710
liMT
















3711
liver




















3712
Liter








EUOSDU MOTE

















^___^_^^__

















































1IUTTIC1L
•ETBOB
US















11

















US





















us
It








ITHBES
Of CUES
















a) 8
b) 6
















a) 8
b| 9
c) 11



















1









MICE

a) lot givea
b) lot given
c) 52-281 pp«
4) 75-605 ppi
laa vt











0.66-11 ag/g (vet «t)
b) 2.4-1S ag/g (vet vt)
















a) 0.071-1.16 eg/g;
b) 0.080-3.21 ag/g
e) 0.0010-4.8 ug/g
Vet vt


















a) lot applicable
b) lot applicable








•111

a) 2«8 ppa
b) 2*4 ppi
c\ 143 ppi
d) 287 ppi
ish vt











a) 4.2 » or - 3.5
»g/g («et vt)
b» 8.9 * or - «.5
aq/g (vet vt)














a) 0.32 og/g
b) 0.96 ag/g
c) 0.72 ag/j
Vet vt
Bedims

















a) 172 ppa
b) 210 * or - t ppa








GEIEI11 mOIUTIOl

i) 17 eaacer patleats
t) 58 BOB-ciBcer patieat*
c) 10 BOB— Backers (never snoked)
a) 11 siokars
c) aid d) 40-70 yr old aal«s.

•atopsies fro hospitals la lorta and
Soith Careltia. Blacks aid
Caacaaiaas. Adults, ages 16-91 yr.
CitUraa, tgas 1 days-t jr.
i IT its; softs: inEi; HOISTS:
« CHITS; C1IIOBB1; CIDBI0B; II»C:
HID; 10 wi cuouii: SOOT a CMOLIII;
inopsm: HOICCTIOI.ITIOI: IICIIL
siniiES; net: swntxsi TOBICCOSJ SEX;
IIOPII3BS
I) 1«1«S
t) Teaales

Iioa a groap of (1 aatopsiea.
forensic aedical exaaiaatlons. Japan.
Bales, lean aga 40.6 yr. Teiales,
a«an a^e 37.4 yr.

111CC tlEBIBTS: IBTOPSIES; JlPlI;
unBiHB: iisnic: CUBIOB; COBUT;
cisoiiina: ctiPiB; i»n: Biicrat;
IIOIOS; S1GIISIOB; ailCllESE:
SIIEIII*: timiodl TIUDIIB; tnc;
CCIDt BBOBIII: LirEB; UDBIIS:
ClBEBtIB; CtEFBIIlUB: BHBl; BOSCIES;
IIICIE1S; SPIIB1; LOassj 10111;
B1T»S; COBFIBlTin ET1ID1TIOIS; SE1;
ICBIISIC ISOICIIZ
a) controls
B) locker grogp I
c) florker grcap II

Caceascd reflaecy and snelter
•orkers* aqes 55-76 yr, exposed to
btiTf ntals 1-3 decades. Tlae
tetveen retireaeot and death 0-1.5 yr
ill IJIDIS I and 2-19 yc, groip 11.
ccntrola. aqes 43-72 yr, vho lived 50
ki froa tbe factory. Svedes.
Slttll; Cltims; ItHlITS; liyiB;
IOISS; COBP1S1TITI E11L01TTOIS:
IECOST8I1I BISIEK: RISOBEBIIT
B1TBODS; lITIBOXy,; 1BSBIIC; ClDBIOa;
CISIOB; CBBOBIUn; COBlLTi COIPEI;
GCIDi IHO»: llTTBllOa; LEAD;
BIBG1MIS1: ntBCTJBI; BO1TBDEI03;
IEOSPTO80S: BOBIDinfl; SCIIDIOB:
51IE*ID1; SIIVES; TIB; TOIG5TEI;
IIIC: BIllTt B1ZIBOS; IVDOSTBIIL
FIltTS; sniIEBS; TIIIOBIOB
a) ae&sared cy IAS
t) ••asnred IT la

Intopsy speclieos. Battery plate
Baker, vorked vith ca for 36 yr.

BOIES; KIBItIS; J.ITIB: IUTOPSTES;
C1C8IOH; H1IIS: OCC5PITIOIH1
EIHBDS; 3-IHtD KIIGDOB; OCCOPtTIOVU
tlSItStS; OB HE
EZRtSICI

Baaier. D.I.
Calocci. 1.7.
BasselblaA. T.
(illlaas, I.E.
Piakerson^ c.
1973
Joarnal of Occapational
Hedicine 15(12) : 954-563








Takava, B.
Sazakl-yasaaoto. I.
laano. (.
Terai, B.
1980
IrchiTes of
iBvironaeatal Health
35(11:36-44










Brone« D.
fordberg. 6.
tester, P.O.
1980
science of the Total
Environment 16:13-35
















Blainey, J. D.
IdUS, 5.0.
Braver. O.S.
Harvey, T.c.
1930
British Joan a 1 at
Industrial Beflicine
37:278-284


(HIT P»5S)
-------
      Cidaioa
      7MO-»3-9
      Cd
      It* 112.10, » 321 C, Bf 7«S C, W 1 » Be at 39* C, 10 » Hj  at «8«
                                                                                            (CORIITOD)
IXSSBI i nvosm nati i amnxcii i
i i stmat i
i i i
i i t
3713 |
liver 1
1
1
1
1
U 1
1
t
1
1
1

1 1
1 1
f 1
1 1
1 1






IIUZBI |
OF CASXS |
1-
1
•1 19 I a)
c| 11
d) 10
«> 10





1 >)
c)
V
e)





1
1
HMS |
1
1
1
lot girts | a) 0.01
lot alirea | ft) 0.33
tot gl»e» ppa
lot alien
lot alien







O 0.97
ppa
d| 1.25
ppa
e) 1.97
PP*
let »t


9B1I

ppa
« or - 0.35
* or - 0.«9

» or - 0,75

* or - 1.08




l ' crntai irroiiunoa
l
i
i
1 a) Jbottnes
I 61 soe> 2-5 rr
I c) aoea 13-K fr
| d) iges 25-31 rr
1 e> Joes «5* jr
1 Cata also qtrea tr "c« «J
I ccctpation.
1
1 iBtopaiea of accidental deaths la
I Cbio, a«aa, ber 7, 1975






 I
 I
 I
 I
 I
 I
 I
 I
 l
 I
I
1 1 1
1 1 1
1 1 t
1 1
1 1
1 1
37T« Imq*atiom | I
Unr t 1
1 1 1
1
1
1
!
i i
i
i
i
i
i
t
i
i
i
i
aed abort****.
tints; ctDinii mil: EIBHTS;
XXTIB; IBTOPSISS: s»o*iw; ICBJCCOSJ
jes: fo?njinw rwosraij mans;
ttoiiscnrst antnttn rms? ono
enl«r. Profil* of taaltbr «nb]»ct«.
(as«ll»* dati for d«t«r»i»ins ekaiigM
IB ntrltiaMl atatas Iroa ItdostrUl
1
t
1
1
t
(
1
1 Sttart*, B. J.
f Rott«son, s.r.
1 1»7«
37T« lagesuos III 1 Cerle*. Profile of kaaltar nb]»c
tirer III 1 (asallaa data for deteralalae ekaa
1 III I ia n«triti«a*l statas fro a Itdoatr
III 1 feed prooessioa tecnniaies.
1 ' 1
II l tit Hunt; 1D01TS; riTVS; 1IT1IT
l l l BIOCII siBim: ui«; KID»TS: inn;
1 1 1 em; imn: mits; FOODS: SOILS;
III l TiejT»Tlo»: ciBsira: coirxts
1(1 I lUSHXSt: B1T11S; TMCI SUBSflSi
III 1 tlK
1 1 1 ,
« » 1 1
3715 1 Inkalatloa 1 1 lot jlren «.« ao/9 »•« «t I 34 sin eipoeere
liter 1 1 1 litopsr tisaae
1 1 1
II 1 I 3« r* old selder
111 II
III 1 Visnaea, persisteat non-prodoctire
III 1 tcogb.
Ill 1
1 f 1 i«atk 5 d«7» after exposare. laxj
III 1 flowed ckaDocs typical of acvte
1 III pteaaoaiti<.
1 III
1
1
1
1 1
1 1
l i
1 1 f
716 I 111 1 a) 83
i*er 1 1 M 10









i DIITII Kiiecci: Kioms: IITIB;






a) 0.8-120 ppa a) 22.* * or - 3.3
fc) 0.6-7.9 fpa ppa
b) 2.6 * or - 2.2 ppa
Seoaetric





t
1
INGS; a tilt; HE4LT8 giZlSIS; ami
rciSOITIG; HOOSTBUI MVOSFHSISS;
IH111TICI; CCCVFITIOfU B1JJSB5;
cicanu; urtJU: »oio?siis


a) lorkers, Cd proeessiaa plait
t) Control*

*aa«e of critical levels far
<4-iaa*ce4 titmlar protelaaria
eatlaated at 150-300 »o/1-

ICBITS: (ItllT DJSEISBS: KIIIITS:
IITEt: II TITO IfUISIS; CIDBlnS;
ifTils: occopiiioiii iiziios

t«. i eatarie, B.I.
ges 1 Kofelason, s.r.
ial I 1»7«
1 »e« Kalaad aedical
1 Joonal (7(<03l:3-B
s: i
l
l

l
1
i

1 tacas, P.I.
1 Jarivalla, J.G.
1 Jones, J.B.
1 S009B, J.
1 Tale, P.t.
1 1930
1 laacet 2(8187) :205
I
1

1
1
1
1
I
1
1
1
1
1 Fills, K.J.
1 Borqso. (.0.
1 Zaaxl, I.
! Tasaaara, S.
I fartskr, B.
1 Coba, S.B.
1 1981
1 Journal of Tozicologr
1 aid ItTlronaestal
1 Bealti 7:491-703
1
                                                                                     (•ire PISE)
-------
Cldsill
7MO-43-9
cd
Itt 112. tO, IF 321 C, BP 765 C. T?  1 la  Bg tt  39« C.  10 II «g at >86
                                                                                      (COmilXD)
IISSSB


3717
Lang

















3718
Ling




















3719
Ing













3720
Bilk








BIMSOBB BOOTB











































Inhalation














IngestioB









1BUTHCU
BEIBOD

Bl


















US














































BOBBBB
or cisBS

a) 3
b) 2

















a) 8
b) 9
O 11



















1
























SHOE


a) lot givei
b) Bone detected

















a) 0.001-0.17 ag/g
b) 0.058-0.78 ag/g
c) 0.046-1.4 »g/g
•at lit


















Bot given
























BB1B


a) 0.90 « or - 0.85
«g/g (vet »t)
b) Bone detected
















a) 0.026 ng/g
b) 0.42 ag/g
c) 0.11 og/g
vet vt
gedians

















4.7 ag/g net vt
























GEBIBAL IIFOBBATIOI


a) Baits
11 resales

Iroi a groip of C1 aatopsies.
forensic nedical ezaalaatiois, Japan.
Bales, sean age 40.6 yr. resales.
staa aoe 37.4 yr.

IlaCB E1BBSI1S; aOTOPSIBS; JAPAI;
llEBIItia; ASSEBIC; C1DBIBB; COBALT;
ctBCBTOs: CCIPEJ: IBOI: BEBCOTI:
IIEITJ1; BAGI1SIBB; BAIGAIESE:
BVEIDTVB; AITIBOBT: SCaBDZOH;
SHSIII4; TI11BIBH: TAIADIOB; ZIBC;
COLE; BSOBIII: UTEB: HBBETS;
CEBEBSIBj; CEIEBELLOB; BB1IT; BOSC1BS;
SIBCBE1S; SHBEI; LOBGS; »CM»;
aillLS; COaPllaTITB IT1LH1TIOIS ; SET;
ICBEBSIC HIDICIIE
at Control*
t) worker groap I
c) lorker grcap II

leceascd raflasry and sneltery
•orkers, ages 55-76 yr, ezpoaed to
heavy aetals 1-3 decades. Tise
b*tveea retlreneat and death 0-1.5 yr
in groap I aid 2-19 yr, group II.
Ccntrols, ages 43-72 yr, *ho lived SO
*• fron tke factory. Svede*.
SIIDBB; CaGaTEIS; EIDBBIS; trTEB;
HUGS; COBPIB1TITE ETalUTIOBS;
tlCOSTBIlL B1SIEBE; aElSOEEBIWT
BIT BODS; IITIBDHT; IES1IIC; UDBIOI:
CISIOB: C1BOBIOB; COBllI; COFPIJ;
GOLD; HOB; IHTBIBOB; IBID;
UBGIBBSI; BIBCnil; BOITSDEIUB:
IBOSPHOBU3; BOBIDIOB; SCJBDIOB;
SILZBlnl; SI1VEB; TIB; TOBGSTEI;
II!C: BEILTB H1ZJBDS; IBDOSTEI1L
ElaBTS; SBEITBHS; TBLL01IOB
30 aia eiposvre
litopsy saipla

3« yr old aelder

Cyspnea, persistent Bos-prodactive
ccagk
Deatk 5 days after exposure. Long
ctoied chaages typical of acute
pteasoaitii.
OIITED KHGDCH: nOBBIS; 1HIE:
IHIGS: nan i: HEIITB UZAXOS; IETIL
tCISOIIBS; IICaSTBIlt UHOSPBEBES;
IIBIUTIOI; CCCOPiTIOBU. BJZIBOS;
ClCBIlfl: BR1IS
levle*. frofile of healthy nbj«ets.
Baseline data for determining changes
fcod processing techniques.

Ill :EILa»; 1DBLIS: EETUS; II'llTS;
ttooi SEIDB: BUB: KIBIETS; urn;
IIIK; B5TIH; DIETS; POODS: SOILS;
1EGFT1TIOI; CABBIOfl; COPPEB;
BalGalBSC: BET1LS; TB1C5 EIEBESIS;
me
IBTBBEBCB


lakan, B.
Sazaki-Tamsoto, 1.
Asano, I.
Teral. B.
1980
Archives of
Eavironneatal Health
3S(1|:36-44











Brnne, D.
Bordberg, G.
tester. P.O.
1980
Science of the Total
EBTironnent 16:13-35
















Laeas, p. A.
Jarivalla. 1.6.
Jones, J.B.
Goagh, J.
Tale. P.T.
1980
Lancet 2(8187) :20S








Gathrie. B. B.
Eobinsoa, a.T.
1978
lev Zealand aedical
Journal 87(603) :3-8






(BEIT PASE)
-------
ctfliiu
ca
»1» 112.10,  BP  321 C. If 7«5 C. TP t mi Bg at 3»« c.  10 u 89 at  «B6
IISSU BXFOSDKI BOOTS 1IU.TTXCU. 1 ITBBSSB JI1BI IBal ( GJI1SU. UTOtBITIOl i RlriSElfCI
HEIECD | Of CASES I I
1 • 1
3T21 U a) C c) tone 4et«et«4
Basel* b> « t) lot glT«
1
1 1 t
1 1 f
1 (
1
1
1
1
1
t
3722 in a) C
P«ncna« 1 J» 2
1
1
1
1 1
1 1
1 1
I 1
1 1 1
III 1
i r i
i i i
3723
srltn
S7J*
otlo«
»

nhalatioa
,
»
n
us
\
\
a) 9
i b) *
t
a) lot «i»«i>
b) Sot giren
) Jot jif«»
1 Cot gives
5-1.2 »g/l
l
1 1
a) lone detected | •) 'fit' I Inlwn. S.
b) 9. 1* » or - 0.27 l t> Feiales I Suafcl-faauoto, •.
ag/q (»t «t| | t IMOO. K.
1 tram a ?roup of *1 xtopsiva, I Tetal, R.
1 | (oceanic cedical muloatlott. Japan, l 19BO
( | Bales, •«•* ao« 40. t re. Feiales, ( Irchirca of
1 i«a> «9« 37.* rr, | tmironaettal E«lth
I | 35|1)t36-«H
t IBICI tiEniis: ioio?siBSi ji»>; i
J 1108I>9«: »5E>IC; CIOBIOB; COBU1; 1
t ceieini; cemi; ttn»; BIECDRT; i
1 noiDg; fnoiisiDB: «a*etiEsi: i
| BOSIDI39; 1HIBOJT: SC1IDII1; I
i fnttii^; TIUH09: Tinnioa; nice; j
l GCIB: itonit; IITEJ: noicrsj i
l CHIBBOS: ciEnmnt; n»i; ivscits; i
l rnciEis: srini: IVKJ: tosti; i
I B«»is; coHrumn mtairicis: sti.- i
i ICSHSIC wmcim i
l i
1 l
a) 1. 2 « or - t.« 1 ») Bales I TuUwa, «.
04/9 (net nt) | t) r«nl«s | Sniaki-UBttMto, i.
b) 2. 6 » or - 3.6 j I liana, X.
"9/7 <«et «t) | Pro* a «couf of «1 autopsies, I Teral, 5.
1 forensic Mdlca.1 araiiutlDU, Japan. 1 1990
I Bales, Mai age 40.6 Tt. Feules. I Irckirea of
1 *
O. 80 • or - 1.6
/j {»et lit)
«V1
a) Rales 1 tataiw. B.
l| F«eal«» | S«aa iq« 37.* yr. | iBTiromatal Bealth
I 35|1):3»-*a
TSICI nilltltS; tOtOPSIiS: JlPif; |
iicama: issMic: CIBSIDB.- cosuT: i
CBBCdlO!; CCEPCf; I Mr: BIBCBET: |
3ICI5J!; usnsiua: MICIIZSZ: t
fUBIBItrS; »»IISO»T: SCHBIOH: |
stLmai: iniiros: Tuinusj sue; f
«C1C; BiOMH; 1JTBE; nniHS; I
CttlBIxt; C»Z9IUna; aXIBI; BOfClSS; I
IIKSltS; SE1KI; LtTIGS: ICB«; C
»»I115: COIPUlTln ITilBHICIS; SEI; I
Kfiisxc srciciK i
1
12 aaiplae | laawson, T,
ClT«et J«t«Tll»atloa «»a •its&ctio* i liAnsto, 1.
icocedvces a^r*e. } 1979
1 Clinleal Ckesistrj
ItlJers, qario* pnraiMl and pgttj l 25(11) : 19*1-1953
letters ta s««di*k airplane factor*. 1
t
iiosniit icixoiioi: coBtuniti i
nnoitiois; ciosiDB; s«!»l»: jtotTs: l
HOCV; i»lil; BtoiccninrLMIoi i
	 , 	 ,. . , « 	
                                                                                                                                                                                  OO
-------
Cadalaa
7MO-43-*
C*
Itr 112.40, IP 321 C, IV 765 C. n 1 ae gg at 3M C. 10 •*  Sg at  486
                                                                                      fCOITIIDEIl)
tissn

3725
Dilne















312*
Urine









31TI
Orlae















312*
Brine








EZpoSBBB BOOM

Iggestloi


























Ingest Ion
Inhalation
























auiRlcii
H FT BOD
US



















































BVBBEB
OP C15IS
•t 34
b) 38
0 22
d| 20
























b» 15
c) 24
41 t«
e| 19
0 7
9) 21
hi 21












1








UBCB

a) lot gives
b) lot given
e) lot given
1} Bot given
























a| lot given
b} lot gl?T4 Tr.
Ccitrola fcot IsnitiH Prefect ice.
Ige* SS->10 ir.
Creetltine clearance and « reaal
(icctlioiaa Eeaisocotloa decreased
algalfleaitly in cd-eiponed subjects.
rrcteinorea, gloco«rea, and
J1PII; aOOITS; K10IIT BISIaSES;
BIOOD; VBIII; EIOiCCOStTLKIOl; iETlt
toisoiiis: tins; IIDJSTSIH
tcmrtioi; CIEBIOH
1 Tevlea of research la Industrial
*aea for aad envlroanental effects of
Cd, as reported by the International
lead Zinc Orgaailatioa.

Hint; CH8IBR; HBT1LS; lEISVtnnt
IIIBODS; II TITO IIIITSIS: BIOOD;
ifin: EIEIIT DISUSES; BOII
HSElSES; OCCOPUIOU1 DI5B1SBS:
FOPtmtioi tiposnB; iinosiiiit
ECIURIOB
a) Coys living < 1 k» froa naelter
t] Sirls llvlnq < 1 ka froa saelter
cl Coys living 2.S km froe enelter
d) Girls living 2.5 ki Iron enelter
e) Drban tovs
f) Vrbai qlrl*
g) Ural boy:
M Imral girls
tatlaatel ftca graph

School-age chilicei living nenr Pb
tnelter in Belgian. Controls froa
rntal anl mean areas.

Biieaitsi: cmsios: usiiic; IESEIIC
CIG1BTC COBPCOIIDS; CHUBtli
IIDOSTIIlt tlBDSPKBlES: SailTESS;
EIIILS; BIOCD; V1IIE: BEtSIJH;
TCPULiTIOW EIPOSOJB: EOH1 tlEaS;
IBEII tins
teunc«4 7 S to it a,f.t«r einos*c«

letopsy specimens. Battery elate
»k
-------
      CalaiM
      T*»9-»3-9
      C«
      HI  112.10, BF 321 C. It 765 C. H» 1 M B» at  39* C,
                                                          10
                                                               Bg «t
        HSSOt
                   EXFOSBBt IOOIE
                                       nunictL
                                        HKTBOB
  |   HBBSS
  I  Of ClStS
  |	
                                                                              ttia
                                                                                                                               eimii iiroKimoi
                                                                                                                                                                    IlfZUlCl
       372»
       Dtlna
    a) 70
    b) 60
   a) o. 002-0. t5S ag/br
   b) 0.015-0,365 «o/kr
                                                                                                                     I
   a) 0.0*0 » or - 0.00*
   aa/az:                 t
   b) O.fl»3 » or - 0.007  |
   tto/kc                 (
   (S.S.)                 I
                         I
                         I
                        I
                        »
     •1 Coatroli
     c) tesideats of pollute! area

     reaea. *»** age »2.3 ji, froa
     Cd-polleted area Ui*?e>, lad
     coatrols, a«at  aoe B1.1 rr, froa
     ttarlerol,  Belgige.

     BIOOO; StOOB FIA5U:  OBIII; CJmlOB;
     nit: iiicntT: tiKs  smis; sstetvxi
     Kit tantuioi KVosnK;  iicnsniii
     PCIHTTIOI) SltllHS;  KIBB1T CISI1SES
     I  l«ol«rjs, B.
     I  »oel«, B.
     I  Bernard, t.
     I  Backet, J.f.
     I  1980
     t  lateraational IcckiTe
     I of occupational and
     I iDTltooMBtal Vealtk
     I  «SlZ71-27*
     I
    I
    I
      3730
      Urioo
                  lakalatloi
                                                                  lot applicable
                                        ( 2000 naoVl
                                        I
                                                   I  30 aia aiEoxan
                                                   I  lit«*iortt* letel
                                                   <
                                                   I  3* rr  oU ««i4«r
                                                   t
                                                   1
                                                                                                                     Caatk 5 Jan after exposure.  long
                                                                                                                     cfeond ciangea typical of acate
                                                                                                                    Bimi KiicicB:  mini:  tims
                                                                                                                    IOI6S; mil;  BU1TB B1I1KBS;  gRtt,
                                                                                                                    FCISOHI6:  iitusniii ITIDSFBHSS:
                                                                                                                    lioit»Tic»:  ccctrpirioiu.  MIIBIIS;
                                                                                                                    CltitBB:  HTatS; iffTOPSIIS
                                                               I
                                                               I  Local, P.I.
                                                               I  Jarivalla, i.e.
                                                               I  Jones, 3.B.
                                                               I  sough, j.
                                                               I  rale, t.T,

                                                               I lancet 2(81aTJ :205
                                                               I
                                                               I

                                                              I
                                                              I
                                                              I
                                                              I
                                                              I
                                                              I
                                                              I
    J731
    OClB*
               InialttKu
a) 60
b) as
O 7*
a) 0.015-0.365 nij/lir
b) 0.012-0.T19 OJ/kr
c) 0.002-0.ISt ia/ar
a) 0.077 aq/hr
b) 0.047 ag/br
c) 0.030 «g/hr
Geoeetric
                                                                                                                                         («»t (dilated
 I
 I at lesUeata at
 I a real
 f t) BesUeit* of Brussels (less
 I Fcllaved tr«a)
I c)  teslieats of Charl«roi  (ceatral

I lie** resldects Uffervd ftot
  Caarleroi fp(0.01) tat tram Iraaeals
                                                                                                                   Malta* sabjccts >SO rr old,
                                                                                                                              f tft« m»mf ar«as 2S
                                                                                                                           itniTS; let; BLOOD rusai;
                                                                                                                  ff»I«!; eitSIJS; IIIB; SIECOEI;
                                                                                                                  eitiis; me; mtsTRiu BBISSIO»S;
                                                                                                                  IfDHST>Ilt fCtLBTIOI; POP0tlTIOI
  I Eoela, B.I.
  I l«o»erT», S.S.
  ( Bucket, J-P
  I Bermard, t.
  I 1981
  I  ZaTiroacutal  3esearch
  I  24:117-130
  I
  I
  <

  I
  I
  I
  I
 I
 I
 I
 I
.1	
I 3732
  trrla*
                                                               a.»-28.5 oo/l
                                                                                          tot glr«»
                                                                                                                  t*po»ti  6-30
                                                                                                                  ItNTS; BIOOO: ID1ETS; VSIIE; H
                                                                                                                  tin  ifUTSiS: lusnsnix anfcss:
                                                                                                                  cionti: occvFHiorii BHMBS: amu
                                                                                                    f  IHqraa, L.
                                                                                                    I  Mttsaoo, S.

                                                                                                    t  Pariica io BedlciM
                                                                                                    I  Btolwjf 2«(1):1»-2«
-------
7MO-70-I
ca
It* 10.OB,  IE 850 C, SI la«0 C, TP 10 M Eg at 983 C
1ISSII

3733
Blood

















373*
Blood,
seras


















3735
Braia














373*
eraatli







EIPOSOK BOOM
























































Inhalation








UllRlCtL
OETBOD



















us



















us















Fin








niBSS
OP C1SES



















a) 260
b] 2«0



















3















1








MICE

«) lot aiTat
b) lot , set.
laagtk of reside DC* , aarital and
•coaoale at at as, occupation, noaber
el ckildran. sacking habits, ht, at.
la kacd-eatar araa. aloaificaat
Itctaasa ia ayperteasion, ice
ataoraalitiaa, aad krperKieaaia.
iiisis: aissciBij isnis:
CItDlOTiSClnM DISBUSS;
nrrnnsioi; BLOOD SEIVB;
CCBPlSlTITt ITILDIII01E: CIDBIOi;
CltCHS; CtlCllni; IMBWS;
iieiism: IBOSPEOIOOS; pmissioa;
saotoi: TIIC-. BIOICCBSOIHIOI:
CII1S1K *lt»
a) elotraa pallliD«, 11 saaplvs.
ecctetclmt of rariation (CT) »0.«
l\ Catdat* oicleis, 13 aaaplas, CT
3S. 9*
c) Pataaan. 12 caaplas. CT 33. Of
1} Salstaatia nlgra. S saapl«, CT
*1.t«
«t Cerebtal cort«i, 17 saaples, CT
43.0f
f) Eippooaapas, 13 saaplei, CT M.6I

IttgpST saatles

CIEIB5U COitITi SE1SUSMMI RSIBODS;
citctOB; cetitij IEOI; Riieiizsi;
nail: IOTOPSIIS
t«Tal9 aftar «Tponc« to aerosols of
c>a,lk dust froa blackboard erasers a
fiactloa of cartlcla alia. latiaatcd
trca grapk. Tidal volaaa ol about
9CO c« a aid respicatorr frequoncr of
1! cycles/alt aaiataiand dtrlag
taapliag tlaa.
EtllTB: BKCinz; C1LCIOB; CBLOKIITB:
lilt: koTOionrt: ixiosraiEE:
KFUnCE

Cootlmrn, t.
Baltoa, I.I.
larria, B.J.
Giles, R.I.
trovii, 3.K.
Taraer, TC.L.
»111iinso». I.e.
Tortar, J.O.
Barrie, M.I.H.
BcRaf. G.S.
roeock. s.j.
isao
British Badical Joarnal
2<1(<232):11-14





Biaraabaee, R.I.
riaischaan, I.I
Oann. 3.

1975
lAnca-t
1(1»1«) tlOOI-1016














Goldberg. 1.3.
111m, l!
1981
Clinical Caeaistrj
27(»):5t2-5»«











Des*«daleer. S.S.
Riackaater, J.I.

Environmental Science
and techaoloqi
9 (10): 9 71-972



(BEIT PIBE)
-------
Caleian
7MO-70-2
Ca
Itl 40.06, BP 850 C. BP 1440 C, TP 10 •• Hg at 983 C
                                                                                      (COHTUOED)




























1

IISSUE | EIPOSOBE BOUTE I 1IJI.TTIC11 HtJBEIB | BalGE BE1I | SBBEBll IBF08H1TIOB I SEFEBBICE
1 BETBOD OF OSES 1 1 1
1 1 1 1
II II
3737 Inhalation FIXE 1 | lot given 20. 1 ng 1 « 1 sanpled at rate of 1 1/nin, 2-10 1 Ikselsson, K.E.
Breath | | iln after burning * arc velding rods. | Desaedeleer, G.G.
1 I 1 Johansson, T.B.
1 1 I University physics shop, Florida I Winchester, J. B.
Ill 1 1976
1 1 I ftCBIDl: HOtTS; BHEaTH; C11CIUB; | annals of Occupations
i | CCIOXIRE: CBBOKOB: COPPES: IBOI; I Hygiene 19:225-238
| | IIJD; MIGIIISE; IICKEL; POT JS Sltm; I
j I soxFOR; tiTHiuB; viHiDiOH; ZIBC: IIB (
| | PCUDTIOI; FUSES; IBDOSTBUL |
| | MiOSPBEBIS: TRICE EIEBEHTS |
1 1 1
1 1 1
3738 US a) 31 1 a) lot given a) 397 ppa I a) learning disabled I Pihl, B.C.
Bair b) 22 I b) lot given 1 b) 311 ppa i t} Controls I Parkes, B.
1 1 1 1»77
| I 1 learning disabled and nornal 3rd and I Science
1 I I 4th grale students in Canada. 1 198(4313) :204- 206
1 1
1 1
1 1
1 1 1

1 1
1 1
1 1
1 3739 i 1
|

1
I
1

I
1
1
1
I

1
I
1

1

1


lair 1 1
1 1

1 1
1 1
1 1
1 1
1
1
1

1
1

1

1
f



3740
Bair











3741












Spinal
cord

























































n












X-ray spectron


































1









a) 42
b) 40











7
12






















a) 63-1501 ng/g
b) 77-2068 «g/g











a) 29.9-94.1 ug/g
b) 17.2-66.3 ig/g
ry *t












1 1
| ClICXHR; R1GIESIOR; POTASSIDB; I
1 seems; CIOBIDB; COBU.T; COPPEH: i
| HOB; IBID; BaRGalSSE; ZIBC; |
| CBBOBIOB; LITBIUB; HE8C!JBIi BET US: |
I BUB; CHIIBBF.I; CllaOa I
1 1
1 1
1 Beviev. 2* representative I Chittleborough, G.
1 tre-analysis treatments are 1 1930
I tabnlated. The feasibility of a I Science of tbe Total
1 holistic, so-nash policy for hair | Environment 14:53-75
1 analysis is outlined and sgpported. I
1 1
I BEVIES; TB1CE ElESEITS: SUB; |
I ltSTBU.Il; RIaStTBEBEBT SEIBCDS; |
I HTHS: PBOIIHS; COBP1B1TITE |
I MllOlTIOBS; IIOBIBOB; 1ETIBOII; I
1 iBsiiic; itaiiTB; BEOaiiz: CIDHIOB; i
1 CIICIBI: CBICBIII: CBBOHIUB; COBILT; I
1 CCPPEB: sunns: GEBBIIIOB: GOLD; i
1 ICSIIE; IBOI; IIITBIIVI; LE1T; |
I E1SIESI0B; BIBGalESE: BESCHBI; I
1 ICLISOEIHB: iicKiL: {BOSPBOBOS: i
1 fOTISSIOl: EOBIDIUB; SILEIIUB; I
1 SIIICOI; SIITEB; SODIOB; SIBCITTOS: |
1 SOIFDB: TIB: TirinaB: TDIGSTEB; i
I me; ZHCOIIU8 i
i i
l i
a) 26« ng/g 1 a) Controls I Ryan, O.E.
b) 210 ug/g | b) Stltiple cclerosls patients | Holibecher, J.
ledians 1 Sanples fron 7 scalp sites in each I staart, D.C.
1 cnbject. 1 1978
I I Clinical Chenistrv
I C1I1DI; IDniS; CEBIB11 BEBVOnS | 24 (1 1) : 1996-2000
1 £1SIEB 3ISE1SES: H1IB: ILHSIIOB: |
I IBCSIIE: cucnm; CBLOBIBE; COPEEB: i
I ecio; IODIIE; niGiiiSE: BETHS; i
I SfLEIIfl; SIITEB; SCDI8B; SBimB; |
1 I1«10I05I; rllC 1
1 1
1 1
a) 54.7 * or - 27.9 1 a) Botor Deacon disease patients I Rarlander, B.B.
ttg/g | b) Controls 1 Patten, B.R.
b) 35.0 » or - 15. 1 I ventral horn tissve. aatopsy 1 1979
ug/g 1 1 Innals of leorology
Dry lit 1 Patients died of nyotrophic lateral I *(1):21-2«
1 sclerosis aad progressive sescnlar I
1 atrophy, nan age, 58.6 » or - 13.1 I
1 ?i< Control: died of various 1
1 diseases at (0.9 » or - 11.1 yr. I
1 1
1 1MIS: 10DL1S: aOTOPSISS; 1
| IMSOimCULIB DISUSES; SIII1L COBO; \
\ cioiccvimtaTioi: citcimi: cotpii; \
1 IICI*. ItlCs IMCanSf. ISTlUt \
\ siitirm IIK i
-------
CirtxM tatcacUocid*  II CI)
tataait. tctucUoro-  n CI)
««-23-S
CC1*
!I 153.8*.  IP -21.6 C, BP 76.8 C. TP 100 » Bg  »t  21.0 C
TISSUE
37*2
Brtatk


KfOSOtt BODTI



IHITTICU
BITBOD
ec-is


BDBBM
OF ClSES
54 (397


BMSI
lot aivea


U1E
1.4 ag/1


GIBIB1L IBFOllallCB
S*amr<4 at 25 c aid 7SO » Hg
M.~n occnxitace
Icier a«d «p«t oae-Sigaa Halts 0.»3
aid *.< 14/1
Bealtar. 19-35 ir old, noeaaoklEK],
•eta* blieka aad eaaeailaas.
Cklcaga. 11. Bigldlr controlled
aipcriaaatal ooidltloas.
flllTB; 11CCB01S; ILLIWIS; 1D01TS;
CtlOtliniD BYDBOCHBO1S; TOUTILI
ciGiiic coipcinos: BUITB HIZIIBS;
fO'BHTIOl IIPOSOBI: OBBll 1BI13
BEKBEBCt
ECOtOSXIDSkl. B. K.
Brnneav. G.I.
C< Belli, H.J.
1979
Joacaal of inalfttcal
Toilcology 3:225-23*


 Ctlill
CI
It*  132.90SI. IP 28-5 C, BP 70S C.  TP  1 •• tg at 27S C. 10 ai Ig it 373 C
TISSUE
37*3
«UMT





















HPOSTOE BOW!























iiumcu
BET BOD
»






















main
or C»SBS
i) e
b| S
c| 12




















utei
a) 0.006-D.058 tg/y
i) D.OO5-0.064 ag/q
C) 0.009-3.057 ltq/9
fet »t


















<»BIT
Bill
a) O.OU ug/j
b) 0.01T 09/9
c) 0.021 ng/9
let vt
Heliats

















PUSH
emut iiraiiiTioi
a| coitrolt
b) (atfccr itoop I
cl Mt»«r gicap It

t«c«»*«d rtfiaerr ud ia«lt«c
norkecs. ag«a 55-76 ji, exposed to
k»*T ««tal« 1-3 decalo. Tiie
tctiee* cetimeBt and death 0-1. S yr
1> gro«p I aid 2-19 TC, gcoa; II.
ccatmlB. a«es 13-72 re, vio lived SO
la fro* «« factotr. S««d«m.
S»m: CICITIKS; KIDIETS; LITE1;
IOISS; COBMUTXT* BTlltHTIOIS;
IlDDSnial 8ISIEII: BStSOBIinT
HIBODS; iniBOIl; 1BSZIIC; ClDIHIi
CISIHB; CBtCBIDI; COB11T; COFPBB;
coin: isoi! imiiiva; ins;
tllCtlBSE; IIJCUH: tOtlSDimH;
EtOSPBOtDS; IVBIDtnB; SC1IDIIB;
smmi; sitTEE: TIB; toiesni;
me: Bum Huuas; inmsniu
fLktlS; SBttTEES; TBUDIIOI

BIHBBIC!
Brine. 0.
locdberg. G.
Wester, P.O.
1980
Scle*oe of the total
En»lroua«»t 16:11-35

















                                                                                                                                                                                      LJ
-------
       Cuimi
       YUO-W-2
       C*
       Itt  1JJ.M5«, n  28.S C.  BP 70S C. T) 1 u If *t 179 C.  10 n  89  «t  371  C
                                                                                             {COITHIIZII}
iissoi mosaic tom iniRicu
BSTSOD
37M U
Unr




t

1
1
1
I |
II 1
1 1 1
1 1 1

l
1





t 1

17*$ I U
laaa t
1
I

1
1
I
1 1
( 1 1
1 1
1 1
1 t
1 1

I
1






•OBBEI
or cuss
a) 8
bj 9
et n






















8
9
11





















1 »MI

a) 0.01»-0.05Z aoyg
b) < 0.0010-0.0*1 U9/9
Cj < 0. J00«-t.0«3 t«/a
««t «




















|
a) 0.005-0. CM *g/g
b) 0.00*-9.0*8 09/9
c) 0. 007-0. flSO aoyj
tat *t




















8ii i t eiiiuL inratUTioi
i
a) 0.018 oj/9 1 it Control*
•1 0.3065 m/g | tj loriar «til> 1-3 d«eai«*. 1t*»
batMm r«tirta»»t aa4 teat* 0-I.S yr
ia qzoap I aid 2*19 yx« orovp 11.
1 cos won, aaas «l-72 yc, «lo 11 wa SO
1 H froi tit factory. s»«d««.
1
I SfiDCi; ciaitsis: ciirtrs; HTM;
IflSS: CO5P1MTII! mUUIIOIS;
IICOSIBIH ireitii; ncison«»T
tltSCBS; jRIBOIT; UStWIC; Clinvc
ctsmii CBIOBHTB; couii: COPFII:
eoic: ito«: imitm: aits
flieimC; fUCBBT; SOLIBDHOB;
EMSMOCVSs IQtlffrVB; SCJVOXDBj
sntnov: sum; TCI: THKSTEI;
tiic; HIITI HJiisrs: iiiosisni
SliftSt SBltltBS; TCLtffSIOR

I nnnict
{
1 Br«a, 9.
1 lordoar*. S.
t vvvtar^ P.O.
1 1»8«
1 sct«oc« of taa Total
1 ZaTlroBMBt 16:13-35
1
rr 1

50 |
1
1
1
1
1
1
1
1
1
1
1
1
1
i
1
1 Brag*. 0.
I lardbara,. C.
1 »«st«r, P.O.
1 1480
1 sci«c* of the fatal
i EorlroBMit 16:13-35
1
1
1
1
1
1
t
1
1
1
1
1
1
1
1
|
1
1
Cklord
C19-M-CI8
II *0*.8, tt 175 C «t 2 »
                                   1110(8-5)  u «9 »t 25 C
l rrsiM i
l i
37*6
•Ilk







l
1
t
(TfOSPXt MtOTC
laowtioa








t
i
iraimcu
SffUOQ
oc





t

t
t

iraszt
OF CUSS
a] 21
b) 24
c) »S
i) »5






1
1
t
IJfSI
a) 4-4.150 ppa
b) 0-0.733 ppa
c) 0-0.723 ppa
4) lot 

I
t
\
1 , . . -
-------
Chlorine
77S2-SO-S
Cl
Itt 39.753. SP -101 C. tt -3«.OS C.  TP  «800  u  Bg «t 20 C. 1 •• Bg «t -123 C
tlSSBS

37»7
Breath








37*a
freatk









37*9
lair

















3750
Bair












ixfosms MUTE

lakalatioe









Inhalation











































1IUTTICU
SRBOD
rat









HIE





























»













man
OF CASKS
1









1





























«l 23
b| 19
e| «2
d) 14
•t 26
f) »0








11KB

8-0.005 ig/cn •









let given





























a) 230-5(20 ««/9
b) 20-910 ««ya
e) 20-5620 og/f
d) 230-2710 og/g
•) 20-2120 Bg/g
f) 20-2710 ag/g








BUI

lot giren









29.8 na





























a) 10«0 ug/a
b) 360 Ig/9
c) €90 og/9
4) 1570 ng/g
et 780 sg/g
f) 1050 ag/g
sedians







CIBIlll IBFOIB1TIOB

Ut«r aitoiotiT* Pb htlld* Mro«ol
•iposvre. !«*•!• a Cvaction of
TKtlel* sis«. B«tiHt«d fre* graph.
Tidal TOllM of aboit 900 CB » and
respiratory frcvnacy of 15
CTCl«s/ili aal«t>l>«4 dariag 10-aia
saifliiq tia«.
aiiiti: Btcnn; ciicxgR; cnotiiB;
tut: igionmTS: WBOSJBJBB;
tllTICILaTZS
e 1 »aapl«4 at rata of 1 1/iia, 2-10
lia at t«i timing » arc *«lliag rods.

0>l*«raltT tkyslcs »hop. rlorlfta

tUBXBt; 1E11TS; BBBIIB; Caicloa;
CBLOBIBBi CBBORIVBi COPPEls IBOB;
mo: BiBeiBisB; ncdi: KTCISSIDB:
SBLFBi; tninoa; TMIDIOB; TIBC; in
KJIIBTIOl: TUBES; IBDBSTIIll
ItBOSPBBBBS; TH»C« BIBBEilS
B«*i*«. 2* r«pr«*ntatiT«
Fr«-aaalTsi< tr«at*«>ts ar«
tafeilated. Ike fuilbi.li.tT of «
kellitlc, ao-«a>h roller for hair
analysis is cot lined and supported.
itrixB; TBICI BiiatiTS: BIIB;
HSnUIt: BI1SOBBEBR BETBOOS;
IITILS; PBOIIIBS; COBV1B1TITI
HHBITIOBS; UBBIBOB; 1BTIBOBT;
IBSIBICJ B1BIOB; BROBin; CIEBIOB;
CI1CIIB; CBICBIBB: CBBOBIOB; COBU.I;
ccppSB; sutjDB: GSBBIBIVI; ooio:
ICCIBt; IBOB; HBTBIIUBJ LB1E;
BISIBSIDS; BUCIBESB: BEBCOBI:
tetiBotna; BICKHS PBOSPBOHDS;
MiissnB: BBBionia: SBLKBIOB;
SXIICOB; SHVEB; SODUJBJ SIBCHTWH;
SIIFOB; TIB; TITIBIBB; 30BCS1EB:
MIC: UBCCBIOB
a) Bale controls
t) Tonal* eottrols
c) 111 ccntrols
1) Bal« saltiple sclerosis patient*
•) F«n«l« ssltlpla sclerosis patients
f) 111 Btltlrls sclerosis patieits
Staple* fros 7 scalp sites IB eack
(ifcject
ClBIDl; 1DBIIS: CIBTBU. BIBfOOS
fisTEB oisBists: BIIB: UOBIBBB:
MOBtBB; CIICIOB: CBLOBIBE; COFFEB;
cciii xooiBi; BiaciBisi; HBTILS;
StlEBIOB; SIITSE; SCSIOB; S01FDB;
IIBIOIOB; IIBC
HHSZEC!

Oesaedeleer, 6.6.
Vinekester, J.».

EBTlronwntal Science
and Teebnology
9(10»:971-»72




Ikselssoi. K.B.
Desaedeleer. G.s.
Jokasssoa* T. B.
Winchester. J.B.
197«
Inuls of Occopatioail
Hygiene 19:225-238




Cklttleboroagk. C.
1980
Science of the Total
Environment 1«:S3-75















Byan. D.E.
Bolibecher. J.
Stuart. B.C.
1978
Clinical Ckenlstry
2«(11):199C-2000








-------
    Cfclcrototi |t CI)
    Catkua. trlchloio- n  CI)
    «7-«S-3
    C-S-C13
    » m. 39, H -63.5 c,  re  100  •• ig it  10. • c
















1
1

1
1
r












TISSUE EXfbsm BOVII i 11*11*101
I BCTBCB
i
37SI OC/BS
treat*





1
r
i
i
i i
r i
i i
i i
3751 1 ee-BS
Breath i







1
1
1

l
1
i
1 TO a sra
1 or casts
i
8



|
f
|
1







s* fr
f
1 minis; ciictttiT» BIDIOCIBBOM:
i CBIO1IBX OBEWXC COWOIMDS!
| CBlCflOSBaTZBifKrj FKFO9XVS COBPOVUkS?
1 isriiB: uccfois; THIS: (Dints
i

23.3 ag/1 r Manrat at IS c «Bd 7CO •• Bg
SaOMtrlc I «2- Tf oci«rMBc»
I lerar «a *PT*r OM-slgaa lialta 7.»
j ait 73.7 >g/l
1
1 B«alt*T> 18-35 yr olfl, •oB«aklag.
I «t«a Hack* aad ea>casia».
1 Ciieaqa, 11. ligidl; coitiollvd
| «p«clMatal co*dltlo».
1
| E1IHB; ItCCEOIS; II1IBOIS; IDOLTS;
| CBLCSlrlTID eTDBOClEtOIS; TOHII1I
| CESlnc COiKITIDS; iniTI BlllBDS;
( 3IBMHICI; BETIEOUSS; gllaMlRBS;
J fOMLITIOB timSDBE; nB» IBB1S
1
IMBSCTCI


Cookl*, J.P-
CMP, ;.J.
Mich. B.S.
1»7S
lrchlr«» of
EDTlrouotal Bealtk
30 (2) : 240-295








xrotoaimrtl, B.K.
Braaeaa, S, «.
O'Balll, B. a.
197S
Jotciwl at laalytieal
Toilcalogr 33 225-23 «










              l » CD
9 . W-5«oaeBi>lwu-S.7.131W] -Irlei-J-M,
«»-97-a
CS7-J<»-0
•1 381.62. H 8«-85 c
I TIJSM
1

1 3753
I Blood,
scrva






















SirOSBlE BOffTJ







i
i

















l iiiiTiieii
1 giriov
1
f

Caipetltiw
ttndiog



1
1
1
















OP CISSS

15
























| BM6I
1
-1 - -
i
a] Pat qlrca
t>) rot glrei
cj (at giren
3) lot g-lta
e) Bat jl»«a
1) Bat giT«n
gj Rot glvu
h] lot jtiei

















1 Kit 1 fitlEIK I»rOSUTIOB
1
1
a] 2T «c - 3 atffi. 1 rt 2S-trdrciTTlt««i» D fi«tatollt«) ,
b] 28 «r - 1 94/Bl 1 15 CfcLldno lltb blool =t of 1D-24
c( 23 or - 1 og/al I o?/r*£tuia 9
1 U-etiboUMJ, cUldrca is a]
1 f) 1.25~dUTdroxr>it»l« K/ etlllrea
1 In W
I gl 1,J5-diliTdror7Tlts«io D, children
1 1* c|
1 i) 1,2S>4tiTdroxrTitMla D. ehHdr««
1 i» e| <(t«c ckalatiaa tterapj.
f
I 1-5 71 old«. BT
1
{ itii: f!Ti.m D; cinoiEr: in TOIK;
1 IlOCt; COBPtllTITE (niniTIOIS: BIOOO
1 SMOB; SETieciisB; smsoiiiis:
1 EIOBOIICBOItClIClrSBOlS
1
ftrtxaci

9039k J.7.
Ctaner. 3-1-
a««»tn, I.
D«Ioca, B.T,
!ab>ff€T, I.E.
1980
Vttv BoglaoA JoorD41 of
HclidBa
302 [2«» r1T2a-iui
















-------
ciroaloa
7MO-«7-3
Ct
Itl SI.M6, tt 1990 C, BP 2«*2  C,  TI> 1 u 89 at 1«f6 C,  to •• Bg at 1ft«0 c
11SSM

37!»
t«I«Ul
ala»d












3755
lort*
















3756
lorta












3757
Blood,
plaaaa








BIPOSBBB BODIE



























































11UTTICU
HFTBOD
us














u

















us
























BOBBBB
or cans
> i
> 5













3

















•1 1
l>» 5























S1BGB

) lot glna
) 31.5-156 ag/a »«t .t













Boa* tetcetti

















a} ik>t givu
to) 8.2-13. C «g/g vat »t























BUI

a) 1530 ng/g wt vt
b) lot gina













Boa* d«t*et«d

















a) 221 ng/g »«t *t
b) tot gl»««























GCICB11 IIFOIUTIOI

a) lockvr
b| Controls

JiCaneM ioTk«r, 65 Tr all, at
ctiout* TrcdDClnq plant foe 30 Tr.
tl«a of nxillaty ani lug canc«r.
Cntcols, a««« !S-7« jr old.

Jltal: IDIPOSE TISSII: UHIa; BOII
IIIMI; Will; CISEBttLSB; CMItBOB-.
IIIIR5: IlflEJ LOTES; SBSCIIS;
(iicms; SHI: cnonaii COPPIB;
situs: me; IIDJSTBIJI. piiiis;
1IB1HT10I; COCTO1TIOI11 B4IIBOS;
fctraiiioi IIPOSOM
lal«*

Iroa a aroip of 61 Mtopsivs.
tctcmic aealctl «xa»lutloM. Japan.
Bills, nao aq« ao. 6 T'* T«aal«s,
t«ai ag« 37.* yr.

MICE ZlKIItB: IVTOPSIIS; JIPJI:
iimmu: USEIIC: CUEIIB: COBM.T;
CBtOHHS: COfPBl; IBOt; B1BCDBI;
1ICHJB; B1S1ISHH: DUeallSB;
IDHDIHa: 1RIROIT; SCimiDB;
siiinni: inuioa; TIIIDJUB; UK;
CC1I; BSOSIH; lITtB: RIBHISi
emnni: cnnn&tti; asm; IOSCIM;
fiiCBiis; spun: miss; iant:
B (TILS ; COIFllMIft ETHBIIIOIS; SKI:
ICtHSIC BTG1CI1B
a) torku
b) Coitcols

Ja(aa«M « octet, «5 TT old. at
cktout* (lodocinq plant fox 30 TT.
tl«d of aaxlllary aid lug caaecc.
Cntcoli, ao«A 59-71 jl old.

J1P1»; 1DI70SZ TISSUI; 10IT1; BOII
S1BBO«: tllll; CISBBELtOB; CBIBtBn;
IIBIBTS; illlS: I, DIGS; RDSC1ZS;
IIBCBIU: StlB: CBBOilDB; COSPEB:
EtTUS; UK; IBDBSTBIU PIWTSj
lISKktlOl; CCCOPITIOIIL B12MD3:
tCPOTlTIOI EIPOSOB!
ItTla«. Protlsas IB risk analysis of
e»e*r 1* Bl aid Ct ladmtrj at*
pc««t«d. various coapoanda at*
citvd (kick cana« eaacar ID practical
ciponc* sltMtiou. n« iMd for
4oa* nfistxatioa Is «apkasii«d.
ICBIH; CIBCIBOB1S: BLOOD PtlS-IJ;
I«IS; IIDBSnUI HtSIBK; SETtBB;
CBBomi: anus.- BICKCI; CBBCIIOGBI;
IIOnSTItlil KBOSVEBBBS; IBIVSTBIES;
CCCIPITIOIlt B1KIBDS; IBOFI1SRS
BSJIIBBCB

BTOdo* K.
SlXDki, S.
InrnTa, B.
Beshiioka, !C.
ueo
IBtcraatioaal Icchivts
of ooeapational and
InTitouABtal Bealtk
46:141-150






YokaH, B.
Swnki-lasitBoto, B.
laano. B.
Tecal. B.
1980
lrckl»«s of
BBTiroBMBtal Baaltk
35(1):3«-B«










Brodo. B.
Sozoki, S.
r«aia, B.
(•abixuka, B.
1*80
IntxraatlODal irchiTcs
of OccapatioBal aad
BBTicoBBeatal Eaalth
«6:1<1-150






•orsetb, f.
1*90
Journal of Toxicology
and BBTicoBMBtal
Bulth «(5/6|! 12 W-1227






(IBM PIS!)
-------
Ckniiu
Itt 51. WS.  Sf 1999 C, 3T I6»2 C. W 1 a* 8e at  1«1« C. 10 mm go. at 1MO C
                                                                                  (comma)





















nssn


3TSi
•ena'















mostii mm i IIUKXCU
1 frUOD
l
US




1
1





amin aiaac sij»
or cisss

a) 260 a) lot ei.*en a) 0.012 * or - 0.002
b) 2CO b) vot 9i*ea ao/7
b) 0.0*3 * or - O.OOT
ag/l









1
1
1
1

1
1
1
1
379* t US a) 1
laaa r W '
•arroa 1
^
i i
i i
i i
i
i
i i









ci i»u. nramxioi unurci


a| (aaeii CItr. JU. aard-nater area Bieraaba«.a. B.I.
b) U>MS cttT. *>, aaft-*atec area nelackaaa. l.T
Siaiificaitli kt^ker lent (r<0.01) Baaa, 3.
it »ft~«tex area.. Inold, J.
UTS
IS «md 10 reeldeate aatcked far age laacet
(aeaa a«ea 37 aad 3T.7 rr|. eex. 1(|eia)s10M-loU
lea«tb of realdeac*. aarltal ud
eceaoetc etetas, oecapetioa, aeabec
cf ekUdrea, «aakla« kaMtcv kt, »t.
I* karl-aater area, etoaiflcaat
irereaee la fcrvertMicioB, ICC
araorealltie*. aad krpererlceala.
R1VSIS; BYSSOVBXf AOVtTSi
CIltlOTMCMII PISIISIS;
• CPf*TnSZOa. BIOCD SBKOB;
CCIMUIin CTIIUTIOMJ C*»ntl;
cticnii ciionofl: HTBHTBJ
B1B1ISIBB; HOStBMOISl KlllJSIinrs
SCBIOT: tnci BiotceanuTtci:
cittrraa ntn


) lot flrea a) 51.3 nj/g a) tarter Irada. X.
k) lot alrea b) 22.* aa/a | >| Caatrola s«nkt. s.
*et rt 1 tmtni*, 1.
t | JapaaeM eercar, 85 fr old, at »«»W»o*«, I.
t 1 caraeate trolacijae plaat tex 10 yr. 1580
I | tied of eadllarr aad laae caacer. lateraatloaal IrcUves
| crttcele. i««d S»-7* fr «la- «t OceapxtloBal aad.
1 A)TlroaM*tal Bealtk
Jin»: tDirosi TISSBC; ioHa; Ban
(iiian nuit cnnutDB; CIIJBOTB:
l f i UBiBTSj art*} utesi aosctis;
f 1 1 *»»cMis; am; cnanaBi ccrpsi;
1 1 MTI1S; tllC; IIBIBMIU. FtatTS;
1 II IBBIUirOlf CCCtrfATXOVll BAX4EDS:
1 1 t 1 CCFOUTIO* tmsni
1 1 11
1 til
I 3760 1 in f la) *ne detected a) Vane detected a) Rale*, cerebraa, 8 mbfcct*
1 Irata 1 1
II 1
1
1
1
1
I
r
l







i
f
t
l
i
f
1

















I b) ftwe detected 1 »| teae detected t) feaale*. ceratne, « nb^eets
1 c) me detected 1 cl Baae detected c) Balea, eacebtllna, c aatjecti
1 d) loae detected d) >oae detected J) teeale*. cerebellaa. • avbjecte
|
1 ftoa a arm of ft *otop«l«».
1 1 (omsle aedleal exaelutioM. Jffta.
I | la]e«, aeaa ao* M.t Tr. rtnles.
) 1 aeaa ao« 3T.< rr.
J
1 II1C1 tLBBIIU; inorsitS; «HI;
I utRna: Msnic; cumntt; COBUT:
t CEfOBHTB| COPm; IBOV; BBBCKBT*
I IICIUB: iicftsiaii tuetitsi:
l mime; iniBoir; scuvrirf;
i Jiinimij tnmiB; nuviai; &K;
l sotr: noitBii imi; nrans;
l cttinni; cfianui: axiit: TOSCIES:
I F1KIII5J SIUBI; LDIGS; 10 lilt
I BtlllSt COBflUTITB >TUIltIC*3; SIX;
i music Bmcrii
i
«:t«J-!5O
















































Totaaa, V.
santl-laaaaoto, B.
tent, v.
1910
lrefci*as of
rnriron»eat»l Eealth
35(11 :3«-aa



































                                                                                                                                                                                 oo
-------
ciroulM
7MOM7-3
CX
Itf SI.99C.  IT 1900 C, BJ- 2CI2 C,  It  1 mm ty at HIS C, 10 •• 19 at 1WO C
                                                                                    (coiTUoiD)
IISSBI

37C1
Bra la














37(2
Bxaath








3763
Bair








37«a
lair

















IUOSBH toon

















laaalatioa






































IBaLRICll
B2TBO0
US















mi









us




























BUBIEl
or cuis
















1









a) 31
bl 22



























•JICI

a) 1st glra
b) lot glT«>
e) lot gink
d) lot glr»












lot gl»*a









a) lot given
b) lot give*



























•Ml

a) 62.1 »g/g
bj St. 5 ug/j
e) 5&.0 >g/g
d) 19.5 ug/g
lut «t











9C.« ag









a) 0.25 ppa
b) 0.09 ppa



























SEIIUl ZITOIIITIOI

a) lorter - o*c*bcaa (teaporal)
fc| lorter - cenbra* (occipital]
<| lort«r - e«r*b*lla>
d) Coatrol - e*c*brua |fxo*tal lob*)

Jataa*aa vorkar. 65 yr old, at
cbcoaat* frodncinq plaat for 30 Tr.
tied of aaxillacj aad Imng caac«r. 5
cntrola. aqu* !»-78 yr.
J UII; llirOSI T1SSDB; 10BTI: BCIS
Biiioi: n»ii: cniBEiioa; cniEni;
me BETS; inn: HISS; BISCLES;
Tiiciiist »iis cnonoi: CCFPII;
BIMIS; IltC; I1BBSTK11 PlliTS;
IBlltlTIOl; CCCVI1TIOIIL B1I1IDS:
icttUTtai tirosots
* 1 aaaaltd at rat* of 1 Vain. 2-10
ata after baralag * arc nlding rods.

Bal»«r»lty ptyulca akop. Florida
ItOIIDIi aEBlTS; BIIWB; CUCIOI;
ccioiiR; ciwiios: eoppii: iioi:
HID; laicmss: sscsns Miassim:
SUPBl; TItllin: VillOIOg; CIIC; III
iciioTioi; ions; XISDSTBIU
niospints: inci miERS
a) learulag disabled
t) Coitroli

l«araiaq ditibled aad aoraal 3rd aad
ata grad* *tad*ats la Canada.
ClICIBl: •aCIBSIDI: (OI1SS1OB!
SCCHa; CatHTOB; COBU1; CQ»SS;
iioi: ii»; iiioinsi; me;
CIIOINI: tltlTOB; BIB CUB I; IBTUS;
•Hi: cniDKi: ciiua
le*l«. 2* x*pr*s*atatln
tt*-aaal7tla tr*at**ata ar*
tatalat*d. Ik* feasibility of a
kellstle, ae**asa policy for lair
«»»lyii» la emtlt**d aat a«pport*d.
ItTIEl; TIKI IlialBTS; Ball;
KSISllIl! lUSOUini BITHOOS;
mus: iioiins; COIMUTITI
imnnoBS; iioiimn: mnoiT;
llSIIICi BlltOB; BSOIIBEt CIDBIOBJ
ciicim; ceicint; cnoBivi; coaiiT:
. «.t.
Da>a*d*l**r, 6.G.
Johansaoa, T.B.
*lack*«t*r. J.I.
laaal* of Occupational
Bfglu* 19:225-238




Pihl, 1.0.
Parkas. I.
1977
Science
1«B(*313):20«-206





Chlttlebocoagh. 6.
19BO
Sclano* of the Total
Z»lreiM>t Hi 53-75















(I1R PISE)
-------
Clrealia
1MO-4T-3
CC
itt si. Me. n 1*00 c.  tr 2««2 c.
                                  T» 1 » l« it 1»!6 C, 10 •• lg at 18«0 C
                                                                                     (COVflKFED)
1
1
1
1
1
1
HSSBI MPOSBBS BOOTB
37«S
Balr
1
1
1
f
1
1
l
BFTBOD

37(6 f M
••art |
1 f
1 1
1 1
1 1
< t
1 1
1 f
1 / 1
i l 1
I01BSI
or cis

•) 8
w *
1 1 *
3767 | U | a) 22
fitter 1 1 b) 3
r i
i i i
i i i
i i t
1J1GI

a) lot gives
b) Bone detect**1
lot gives,
(one detected
iiai i eiitut iiroiBMioi i IBRIBICB
i i
i i
I 1 rsvlev of iiorld literature o* tie I Jaailas, D.s.
I aecMnlatlra and blocoBeestratloa of I 19T9
I selected toxic trace seta!* la tnus 1 E>a-«00/*-7*-0*9, It*
1 ktlr aid sells «al a tier sessallu 1 pp.
1 bait, far, atil*, clavs asd tools. I
I Jaiolated by geographic area, 1
1 »t)ects, sex, *ge, expomte 1
1 gradiest. asalrae* la pp», and I
I aatbaritv free over 400 reference*. 1
1 t
1 MIICI: iistiuia: cauoa; czniu 1
i itznci; tncns HBSIB BIST; n* t
| tZallES; SCm IBXBICl; SOOTBJ1ST 1
1 ISI1; BIXTFD KTK9OI; OII9I9 ST»BS; I
1 iui; mis; BETin; irriBOtr: l
I MSS1IC; BOtCI; CIBBI3S: CBtOBIOBJ |
I CCtJttj CCPFU; LStDl IBBCB1T; 1
I iiciEt; sntiiOR: Hi; Tinnraa: UB i
l fciivrioi; inni pojonnois: i
I HOlCCIBBIltlOI; BIOIIDIC1IOBS; IIIO I
1 iciiDiioi: reroLaiioi titosvtt: ttttt i
1 FOtionoi : IBICB MiBBns: IETIU i
i i
l i
a) 0.07 + or - 0.12 1 al tales 1 Tvxata. B.
ag/g (vet «t) I t) resales 1 Saz*kl-*as»oto, 1.
b) lone detected I 1 >e»o, «.
1 rros a Troop of 61 aatopsles, t Tersl, B.
1 (orsaslc sedlcal exaslaatloas, Japan. 1 1*10
1 Bales, eeaa age M. C r'* resales, t archive* of
1 seat age 37.4 rr. { tirironaestal Bealth
1 1 35(1|:3*-M
1 tsaci ziBBtiis; iraopsiss: »»ai; I
i aiontra; IISMIC: cuutas coiui; i
1 CtBOBTOd; CCfPEK; IBOir; MBCmi; 1
I iiEim; sieiismi; uieansE; i
1 MMDIJI: JIHBOBI: SCaiDIOB; I
1 Sllttttrt; TIIalTOB; MUDIDB; ZIBC; I
1 SOtD: BBOBI1Z; IITBS; (I9BBTS; I
1 CIIEBSOB; ClBtBEIIBB; BEtBT; BOSdlS: I
1 FJUCBHS; SI1BZI; HISS; JOBH: I
I BZtalS; COBP1B1TITB BTlltJkllCBS; 5SX; I
1 fCBEISIC tit Kill |
1, 1
1 1
a) 0.09 « or - 0.3* I ») Bale I Tatava, B.
«9/g (vet vt) 1 t) resale I Sozakl-Tamsoto, B.
b) lone detected I I Isano, K.
1 Iroa a groaf of 41 avtopsles* 1 Teral, fl.
1 forensic sedlcal exaslsatloss, Japan. I 1980
1 Bales, seaa age »0.« ji. resales, t arculres of
1 seas age 37.* rr* 1 Envlronseatal Healta
1 r 3SO):3«-««
l iiacz nEBtiTS: taropsiES; japi»: i
1 110BH7B; JBSJBICi CaOBIOB; COBU.I.- |
1 CBBCBIN; CCtfEB; I BOB; REBCtJBT: 1
I IBOIOB; BaGBESXVB; U161BSSB; 1
1 ismiiB: IITIBOBT: SCIIDIDB.- i
I sniima-. uiaiioB; TI«»DID«: ziic; i
1 CC1D; BBOBIll: UTE1: KIOBETS; |
1 CZIZnUB; CZBEBB110B: BBaBt; BOSCLES: 1
1 EIICBI15; SFIBBI: 10I3S; 10M1; |
1 sniLS: coB?uatiTB ETalvaTiois; SEX; i
1 ICBZISIC RltlCHS I
1 t
lisn MOB)
                                                                                                                                                                                        oo
                                                                                                                                                                                        o
-------
 CftiMln
 7««0-«7-3
Cr
J» S1.99C. IP  1900  C,  BP 2642 C. TP  1 » Eg at  1616 C, 10 •• Bg It  18*0 C
rrssiri

SS,











3769
Kidney



















3770
tine


















3771
liver












ixposni sotnt




































































iBiiTiicit
RfTBOD
115











11




















Bl



















iU













tmtst
or cases
) i
} 5











a) B
bl 20



















a) 8
*i 7


















M 1
b) 5












la KB

) lot given
I 3.«-22.2 og/g vet it











a) < 0.003-0.069 eg/g
b) < 0.003-1. 14 »g/g
»et «t


















a) Bot giien
b] lone detected


















a) Bot gi^en
b» W.7-38.7 ng/g vet at












Bill | SEBZML IBPOBBITIOB

) 128 ng/g net tt I t) rocker
b) Hot given | t) Control*
I Japanese torier, *5 yr old, at
1 catenate producing plant for 30 yr.
1 tied of aazlllary and long cancer.
I ccntcola. aged SS-71 yr old.
1
t Jltll: 1DIMSJ TISSOI; aOSTl: lOIS
t B1BHB; BtllB; CIBmUIJB: CEEBESDS;
| BIOI1T3; I1TEB: 10IGS; aDSCIZS;
I HBCIXU: sin; CBIOBIDS: ecipnt
1 IBBlllTIOB; CCCDPHIOB11 B131EBS;
| KTOUTIOI IIPOSD1I
1
a) lot given I a) Coatroli
b) Bot given t t) Voxkeis. gronp* I aad II
1
1 Itceased refinery and aaelter
1 vexkecs. age* 55-76 rr, exposed to
1 l«a»y aetala 1-3 decades, tine
I Ei yr old.
1
I OIP»: aDiPoss Tjssoz; lOEii; BOB:
1 BIBtOV; atllB; CIFS3ELIDB; CIFEEBOB;
I «mms: uytsj iJBss: auscus:
1 I1BCHE1S; SKIS; CBBOHlnR; CCIPSB;
I irtiLS: 21 »c; IRDEISIHIU pxiirs;
1 IBBlLlTIOB; CCCW11I01IU, E1ZUDS;
1 ECPOTHTOB 1JPOSOEE
imBZICZ

3Yo3o» K*
Smkl, S.
leshixaka, X.
I960
International lreU.Te>
of Occupational and
ZBTironnental Health
a*: HI-ISO





Erene, D.
Vordberg, 6.
tester, P.O.
1980
Science of the Total
Znvironnent 1*: 13-35















Tnleava, a.
Saznkl-Iasanoto, S.
llano, I.
Teral, a.
1980
Irchlree of
EiTixonnental Health
3S(1):3«-«4












BfOdo, E.
Sllrti, S.
rirtya, 9.
1930
laternfttioul Itcairea
of Occupational and
Zniironaental health
46" 141—150






(BEIT PaPI)
                                                                                                                                                                                               00
-------
Ckroaln
1MO-47-3
Cr
»tt 51.»»«. 1* 1950 C, BP 2M2 C, TP  1 » Hg at  16U C«  10 •• lg It 18«0 C
ussti
3772
liMT
1
1
3773
l«*e
1
1
1
1
1
1
1
1
1
1
I 3771
1 l«»9
1
1
!
1
ixrosni tom


1
1
1

i
i
i
I
i
i
I
i
I
i
JkULTtlCll
BETB0D
U
u
us
(

mm
or Cisia
a) »
b) 21
al 3
» ^

MMI iu> i ctBiBit iiroiiiiioi i nrxsncs
i i
i i
i i
a) < 0.003-0.11 »s/q a) lot gir« I a) Cntrola | Btu«. I.
b) < 0.003-0.23 »a/g b| lot aim I 1) (ork*». groip* I a«J u ( BordlMta, G.
l«t »t I | v«it«r. I.e.
I ttcMMl rcilMrr a»8 *Mlt*x | 1930
I nrkvrc, •<)•• 5S-7t jr. •xpow« to 1 Scl*ac« of tk* Total
1 k»*T Mtal* 1-3 tecatu. Tt» | nviconMtt 16:13-35
I bltvMi »tit*Mat aad teatk 0-1.5 Tr I
1 It gro»p I ai< 2-1* jr. qroir II. j
I Ccitrols, ag«« (3-72 yt, »ko Una 50 1
1 >• fro* tk« fictotf. Sv«a««. |
I SIIBII; C»)inS; CIMITS; tlTSB; |
I IBieS; C08PH1TITB WHOUIOIS; 1
1 IltDSnill HGIXIS; SMStJElSMT I
I i iRiooi: iRiJoir; iBsiiic; usnua; i
I i CZSIBI: cnonoR; coatu: cant*-, t
1 1 eOlB; noi; tHTMigi; IJIDJ |
t I MKlltSI: BttCBlI; SOITBBJIOB; |
I | IMSPBOIVS; IBBIBIITSJ SOirlOB; I
i i attnm: mnts ni; roiesnit i
1 i tncj SJJITB HUjiri: neosniM i
i i CHITS: sntTos; numva t
i i i
it (
«) 0.27-1.2 09/9 |Mt .t) | a) O.SS » or - 0.»6 | a) 8al« | Takan, 1.
I Ma* d«t«A«d 1 ag/g (««t nt) I t) MiaUa | Saxakl-Ia«aoto, 9.
1 b] Ion* tetoetcd 1 ( laaao. I.
1 1 tto» a qcoap of *1 aatopcix, I t«ral, 8.
1 1 loraaslc ndtcal naataatiou, Japac. I 1980
1 | lalm. Maa a«a «0.f Tr. r«Ml«a, { lrcfcir«a of
1 I Maa a«« 37. « rr. 1 Enriroaacittl Bcaltb
1 1 1 35<1):3«-*a
i i tiict ninns: utopsns; JIP>I; i
1 i iinnmi: iisinc; cionoi; COBUT: i
i i cnonrai; ccmu IM»; »tcnT; i
1 1 IIDIOI; RieitSIHRj IM6*II»: |
I | BOBMIUS; tinaOIT! SCMPID9: I
i i siunoi; tmnvi; nuoiiu: me: i
1 1 etlD; BlOilll; tITUt IIDIttS: |
l i ciMBius; CEtnin.ua: BUIT; HVSCIBS; i
1 I FUCtflS; Sfirai; IITKS; IOH1; |
I i Bims: ccBfiwTire naioniois: ssi; i
1 i fonsic MticiM i
i i i
l i J 	 - ~
») lot 9! TOT | a) 7100 ng/g I a| Iork«r. rl««t «r;tr lob« ( Byodo. K.
t) lot gi»«i 1 b) «S30 »g/» | t) (ork«r, ri^at aidU* lob* 1 Sntrti, s.
c) lot aiTai | .c) C1C mg/g I c) forkcr, right lo««r lob* | rtriya, I.
9) 96.9-293 »g/j | i) lot gir«B | «) controls, right iep*r lob* I BtsHinU, K.
»> 204-2»1 ag/g I e) lot glraa I *| coatcolc, rtgbt alJdl* lob* I 1980
C) 19.3-13* aa/g | fl lot giTeB I f) Coitrols, cigkt lo««r lob* 1 Ktcnatioaal IrcklTM
l*t «t | (at »t | | of occupational ana
t I Jaraaaa* lorter, t5 Tr old. at | EBTiroamtal B*altb
1 1 ckroaat* trciocla? plaat for 30 jr. 1 *«:1lt-tSO
1 1 ti«a at MXtillaiT aai long ca>«r. I
1 1 ccatrol*, «g«a 5«-7l ri oil. 1
1 1 1
1 i Jim; iDiPosi Tissnj; IOETI: sets i
1 i BiiBoa; BBHI; cnntuw; crasspoB; i
l i mtiEiS; IITEB: LDIGS; HBSCIIS: i
1 l iiicstis; SKI; cnonoB; cotrsi; i
1 l prtiis: Hie; IIDDSIIIU. PlirtS; i
1 1 IIBWIIICl: CCCVPlTIOItl 11I1BDS; |
1 1 fOPTClTIOl HPOSni |
1 1 1
(HIT PIG I)
                                                                                                                                                                                         oo
-------
Ciroila*
7«0-«7-3
Cl
Itf SI.996,
            ir IMO c. tr  2C«2 c, rr  i u 89 *t i«ic c,  to ••  (9 at  isao c
                                                                                    (COBTIVDED)
IJSSOB
37TS
1.19
377«
Mlk
3TTT
Ba»Cl«
37W
.•••el*
•iiosnc Bom




IIUTTXCU
ECTBOB
n
us
u
us
nrnzt
or CISBS
•I a
b) 9
C) 11

al «
b) *
1
I1ICE
•) 0.025-0.72 «9/iJ
b| 0.0*7-1.75 »9/9
c) O.OSI-H «9/9
*«t wt
•) 0.23-0. *« «9/*l
b) 0. ta-O.a; ag/lai
c) 0.19-0.t9 >9/il
4) 0.1 3-0.*. * ag/J«i
a) lot 9l»«
»J tot «ir«»
lot gins
•MB i «mm iiroiBiiioE
i
i
i
•1 O.M2 19/9 I «) COBtrol*
b) 0.32 »9/9 | t> tartars, 9ro«p« I «•« II
O 0.14 tg/g |
I«t *t | r«C«UWlt«t
MAltll | 9«* (3-72 yi, «ko li»wl 50
I »• froi tb« teetoiT. S»«i«i.
1 inon; cigttms: tioins-. ivrn-.
t mesj CORMIHITE Emuiiois;
I niasniit ITSI«K! raisotum
I iRWDS; iniioiT: usnic; CIDBVB:
1 ctsni; cBiotru: ccuur: corpii;
i Kit'. licit iimim: LS»D;
1 tiietnsi; mcgiTi niiSDinm;
1 itonioifs: IQBIDIOII scimira:
1 SHima.: SILTZBt III; TDiSStllJ
1 me; mill aituis: IIDOSTHII
I tuitsj S9HIEBS; mtntzni
i
l
») 0.«3 » «r - 0.13 | t) 10 (otktti, «-1t toy* IscUtlon
•q/il 1 b) 10 Ufaiti. 8-H days oil
b) 0.27 * or - 0.10 I c) 5 lottoT*. «7-S4 a»r» laetatloa
ag/aay 1 <) 5 ialut*. (7-5* tay* old
e) 0.39 4 or - 0.21 I
wj/al 1 Batlmn a«4 twic br«»«t-I«4 imlaats
4) 0.2C «• or - 0.1* 1 It M*lu«.
•9/aay J
1 em: uctHiOBi muw; cnoiini:
i ttius; coarumTx irunmcisi
I IlflBTS
1
a) 0.»» » or - 0.10 I >) l*l*a
09/9 (nt »t) | t) ?••*!••
b) 0.07 » or - O.ia |
•9/9 t»*t vtj 1 Iioi a qiomr at «1 »topxUi.
I fot«Klc H41cal •xailutioal, Japai.
1 (aim. Mai *.g» »0.t yr. T«aaln.
1 ••«• a«« 37. a yr.
1
I HIM ttsBiBis; inomss; JIMI:
1 iioiiws; iisnic; cuaim: COBU.T;
I CltOBIOl; CCimi ItOlj tllCUST;
1 IigiOH; B1SBISIOB1 I1BU1ISI:
1 BUIDIVB; klTIBOIT; SC1BOIOB;
1 sncBini; utiiiBB: TiBioioB: znc;
1 SCID: BBO»I1; tlfBB; SIDIITS;
I ctteanB; cnnxuti: BEUI; BHSCLBS;
1 flBCIt»; SP1EM; 101BS; lOBtl;
1 BRUS; C01FIUTITK ETaLIlTICBS: SIX;
1 fCtllSIC BEBICIBI
1
61.3 19/9 *«t »t |
1
1 dafaa«M «oi1r«c. 65 yc olfl. at
1 cicoaat* [xc4nclB9 VUat for 30 yc.
1 tl«d of (axillary »ai luq canc«c.
1 JIf>«: »DIPOSK TISSUE; MITli BCRS
t qum; niiBi cniBinoo; CESBESOS;
1 RISERS: LlTtt; IHBeS; ROSC1ES;
1 flfCHlS; SXII; CBIOBIgR; COPtll;
1 BITltS; IIK: IlDBSIlIIi fllRS;
1 JBBI11TIOE; CCCWIIIOIIL BH1BD3;
1 tCtQUSIOl tlMSm
1
unMsttt
Braa«, D.
•orSbarg, e.
B«tK, P.O.
1*10
Sci«BC» of tl« Total
EBTlroBMit 16:13-35
r«»p«l»U«a. J.
Tmori, E.
1980
Kerlcaa Joamal of
Cliaical ttttrltlom
33:22*9-2302
Takava, B.
snvkl-Tamaoto, B.
luno, X.
I«r«i, B.
1980
Ircktres of
CaTlroauntal Baalth
35<1|i3C-M
ByoAo, S.
Sncki. S.
rarvya. B.
iMshiivka. R.
1980
latarsational iccUvas
of Oocvpatloaal and
tarttoneital Bulth
«6:iai-iso
lint MSE) "' • '• 	
                                                                                                                                                                                         CO
-------
     Ctroaioa
     7«40-<7-3
     Ct
     »« M.99&, IF 1900 C. » 2645 <. n 1  n  B» at ISIS C, M aa la. at UlO C
                                                                                       (com i HID)
        HSSSJ
                           BOVTI
                                      iitirricti
                                        iznci
     nnaa
   or ctsis
                                                                                                                              GZHUI mosunoi
       377*
       ••11
                                                               I
                                                               t I r«rt« of world literature 100;  111
                                                                                                                  |  lOItOTrOI; JII811 FCPOHriOISf
                                                                                                                  I  IIOICCUIDIITIDI;  BrOMOIClIOES; U«D
                                                                                                                  I  ICIITTIOI; TCfOiJTICl EXFCStBZ; FJIBS
                                                                                                                              inci  ELmns; snus
                                                                                        1»7»

                                                                                      1 PP-
                                                                                      I
                                                                                      I
                                                                                      f
                                                                                      1

                                                                                      I
                                                                                      I
                                                                                               , D.I.
   I 3190
   I call
   I
   I
   I
  I
a) 9
t) 11
«0t
lot
  6.77 * or - 3.99
P"
i)  4.23 t or - 1.25
I i) laaan
» 1) B»
I left ttnib
I Ilso relieved:
I ctbec eleaeats
I
I  Eealtbr 20-«C rr olo<
                                                                               tnooa  larcla of JO
                                                                       SKI:  nits; iMiri! uonnra;
                                                             | IRMOIT;  1I5BIIC; BUIDIi ClSHlrB;
                                                             l cuciBB; cssnu; caBosiuB: CCBIIT.-
                                                             l ccpreB;  etsttaatt SOLO; iso»; IEID;
                                                             I B16I«SIO«: BIIG1KSI:  BSBC0BI;
                                                             I  IClTIDtltia; IICKU; COT1SSIDI:
                                                             I  JOBIBI1H; 5HMIBS: SI1ICOI; SI1TSB;
I Kaaabrocki.  E.t.
I Ksnabrocii,  J.t.
  Sreco,  3.

  Oexter.  r.T.
I  Brar, S.S.
                                                                                                                                                         »«130B, D.B.
                                                                                                                                                         Boon. c.z.
                                                                                                                           UK;
                                                                                                                                                       I Science of tbe Total
                                                                                                                                                       I iBTlronaent 13:131-1*0
                                                                                                                                                       t
                                                                                                                                                       I
                                                                                                                                                       I
                                                                                                                                                       I
                                                                                                                                                       I
                                                                                                                                                                                      00
I 3781
I Pxoctfts
t
           a)  lot fir*>
           t)  foaa detect«d
                       a)  O.fl» + or - O.It
                       "9/1  <»«t »t)
                       t|  ratra dettcttl
                    I
                    I •] Bales
                    I tt feules
                    I
                    I Froi a vr«ap of  61
                   I forensic ndical aiaalaatiooa, Japan.
                   I galas,  aeaa  ao« 40.6 it.  Feiales,
                   r ie»»  aqa 37.* ri.
                   I
                   l ntci niKiiTs: motszssi jititi
                   t IXCBIlffl; tlSEHC:  CIO HOB;  CO HIT;
                   I CB1CII7B; COPPIB: IBOB;  BIBCOBT:
                   I xitm: !nairsim;  aimaisx;
                    	      IIItBOIt!  XUDlUSi
                              iituim:  TiuoiOB;  znc:
                   I GC1D; 5BOS1BIJ  LITBBj HDBIIS;
                                                                                                                fllCBtlS; Slim;  LOfSS;  aCITa:
                                                                                                                IttUS: CCIFIMT1TE  HILTHIICSS; SIX;
                                                                                                                icinsic
                                                                                                             -I-
                                      I
                                      I Takaira,  a.
                                      I SazaU-Tasasato, a.
                                      I laaao, s.
                                      I T-eral, B.
                                    ,  |  1*30
                                      I IreklTes of
                                      I tmlton»eBt»l aealtb
                                      I 3S(1):3i-*«
                                      I
                                      I

                                      I
                                      I
3782
faaeta
                                                              •.1-28.0 ng/g «at at
                                                                                                              I
                                                                                                              I  CottoH
                                                                                                                lq«« 5«-7« jr.
                                                                                                              I JIPH; allFOSE TlSSUt;  iOlll; SO»I
                                                                                                              | Bl«10»: 8X1II; Cl»tE!L10B;  C1BSBBOR:
                                                                                                               I i TOUTS: LUn: LUKGE-.  nasciis;
                                                                                                               I tnci»i; ssi»: CBEOBTUR: cafizi:
                                                                                                               I EllalS; tUC; HOTS1SIU. tlaltS;
                                                                                                                11B»1»TI01; CCCDfUIQIal. B1ZUIS;
                                                                                                                            ItPOSOTt
                                                                                                  I  fjodo,  I.
                                                                                                  1  5«otl, S.
                                                                                                  I  rnrnra, >.
                                                                                                  I  itesblztta.  X.
                                                                                                  I  1980
                                                                                                  I  Iitatnitioul
                                                                                                  I  of Oceopatioaal «a6
                                                                                                  I  tBTltoiaaettl  Haaltb
                                                                                                  \  »*-.1»1-«0
                                                                                                  I
                                                                                                  I
                                                                                                 „»
-------
Ctroalaa
7««fl-»7-J
Cr
Itl 51.996,
            IP TWO C.  BP 26*2 C, TP 1 •• Hg at 1«1< C. 10 •• Bg at 18*0 C
                                                                                     (com* mot
TISSUE

3783
Tkazyax













37«»
Stla













3785
Svleea

















3786
He In*













EIPOSalB BOOtE


















































Inhalation














1IUTTXCU.
nnoD
us














us














u


















us














nun
or cisss
I i
) 1













a) i
b) i













a) 9
b| «

















22














BUGE

• ) lot gi»*n
b) let given













a) lot gi«en
b) lot gii«n













a) lone detected
b) lone detected

















a) lot siren
b) lot gl»en
C) l«t gl«B












IUI

a) 96.7 ag/g
b) 27.9 ig/g
let »t












a) 104 14/9
b) 14,3 ag/
Ret «t












a) Ion* detected
b| lone detected.

















a) S. 3 » or - 3.7
nq/g cceatinln*
b| 33.3 * or - 6.9
uq/g cr«atl«ioe
c) 2«.S * or - 12.5
m/g creatliioe









GIIII1L MFOB11IIOI

a) vorkec
t) Controls

Japaivae vetker, 65 yr old, at
chxout* ccodncing plant Cor 30 Tr.
tied of lailllary aid long cancer.
Ccntrols, agio: 59-78 rr.

JIPII; aDIPOSE TISSUE; lOitl; 1CIS
I1BIOI; Stilt; cntlELlQI; CHIIlraa;
(loins: tTTEB: Liiss: Bosciis;
tllCBtlS; SKII; CBtOBIUll; CCCPE1:
eitllS; CIIC; XIB1STBIU BIIBTS:
iiiiUTici; cccnpiTiom BICIBDS;
tcrotMioi IIPOSHBB
a) lotket
b| Coatrela

3at*n«3e «or)wc. K it old. at
c trout* tEotaeing plant for 30 jr.
tied of •aiillacy knd Ing cancer.
central!, aged 59-78 fr old.

J1CII; aDIFOSE TISSUE; 10STI; BOHE
H1B80I; JE1I1; CEBIBELLUl; CIBEEBIH;
HOIITS; IlftB; LDieS; BOSCLIS;
E1ICIM3; SHI; CBtOBIOB; CCEPII:
Buns: site; inosniu, PIMTS;
iiBjiaTioi; cccopiTioiai aisiivs;
ECPOUTIOI 1TPOSOBS
a) tal«a
t\ r*»i«s

fro i a groaf of 61 aitopaiea.
forensic aadlcal eiaalnatioiu, Japan.
Bales, neea age «0.6 TC. r«aalea.
aeaa aq* 37. • TC.

ItlCI !LEBE«1S; tOTOPSIES; OtPtI;
II.OMOTS; IBsmc; CUHint; COBUT;
cciesni; CCFPEI: iao»; BssctRt:
lltlOE; SIOIISIDB; aafGtIISt;
1IBIDI»; 1ITIBOIT; SCMDlnB;
siLnii*: TIIUTJH: miDinB: Jl«t:
e»D; BMBIBE; 1ITEB; HDI1TS;
CIEEBlm; CttlBELLia: IU1T: SOSCIBS;
ciicstts; sptisi; ines; losu;
B1T11S; COHPU1TITE ETtLOlTICIS: SIX:
PCBEISIC RltlCtlE
a) Stalalees steel veldvcs, ctposed
«.« 11
b) lrao«c«4 steel welders, exposed
1.0 11
c) Carolina platers, exposed 8.9 yr

Italians, lean age 40 yr, taak
•aiafactnrlng

Increase la teta-qlecuronlftasa.
Ttatelnarea, and lysoxyaarla.
1HII; IDOITS; KIDIET DISE1SIS;
Dim; BIOKCTHDIATIOI ; THUS;
IIDTOTBUI PCILUTIOI; IHODSTBIIL
IIEICII!; eiROMTtfll: BET11S
tEFEBZICB

ByolO. t.
Soi»ki, S.
Fanya, B.
Beshtxata. E.
HSU
latecnatloaal trchlves
of Occupational and
Eavlcoaicatal Bern It k
•6:1*1-150






Byodo, E.
S«akl, S.
Fnrgya, B.
B«shlmka. K.
1180
International Irchires
of Oceapatlanal and
EBTlronsaatal Baalth
46:141-150






Takava, S.
Sui»ki-Ia»naot.o, S.
llano, K.
Teral. B.
1980
IrcbLies of
Enriroiiantal Health
35(1):3«-4«











flattl, i.
Caratorta, 1.
Pedronl. c.
EOTgfci, a.
elaroll. c.
Pranchini, I.
1979
International archives
of Ocevpatloaal and
Enlronwntal Bealtk
13:123-133




(MIT P»SB) 	
                                                                                                                                                                                            oo
-------
  Ctroslia
  7»a.O-a7-3
  Ci
  Itl  51.996.  «P 1999 C.  BP 2C*2 C. TP 1 aa Hg «t 1616 C.  10  mm  Ij  at  18*0  C
                                                                                        (COETIEOED)
1ISSBI
3787
vrlae







BIPOSBBB BOOTS









aiunxcu
BETBOO









EUBBZX
or casss









I»6B









IEIB









GEIEB1L IEFOIIHIOB
levin. Protleas in risk analysis of
caacec la 11 and Cr iadastry are
(reseated. Varloas coapoeiids' axe
cited wkicb CMS* caiccr in practical
«ipomr« *iti«tioas. Ifc« o««d for
tea* cealstcitloa 1* •apkaalzei.
icivii; ciiciioms; BLOOD raisii:
«EII!; IIBISItlal BT6IBBE; IBTln:
CEIOnnii IIU1S; IICCZL; C1BCIIOO!»;
iioosTBiii iisosentsist IWCOSTBIES;
cccoriTtoiii Blums: IEOPIISBS
BIFBBSBCB
Beca«t!i. T.
1980
Joarul of Tozicolagr
and BaTlroaaeatal
Health «(S/C|: 12 W-1227





CbZT«Otll«  (8 CI) (TIB)
ctrfMtlle r>»aq3(S12o9j l  (9 ci)
1JOO1-29-5
B10-09-312.3Sq
II 282
f TIS5VB
1
1
I 370ft
I £u?
I

|







1 3789
1 tmmq







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1
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1
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|


















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SETBOO
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I OP C1SSS
1
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a)
5.8ll« (I* 7| -l.'xtO (1*8)
fltwn/9
t>)
1.0z10{Z»8)-2.7z10(Z<-8)
fllwn/9
Dry rt





lot glrea








SB1B

a) 1.071 10(1*8)
flbara/f
b) 1.6l10(I»8)
elbers/g
Dry "t







10 fiber* or
farraginous
bodleo/saiple







GEIIFaL I»FOBS»TIC» | EEVEBEBCE
1
«
a) analyzed at Oni»«r«ity of Cardiff 1 Sebastian, p.
b) lulynd ty laboratory la Paris I Billon. H.a.
Faraachyaa fioa ease of plcoral I Janson, X.
nsotkelloaa I Bocaaad, G.
tata also for aspklbolc flbecs. | Bigaon, J.
1 1978
10ISS; ISB1SIOS; notUSXSi 1 irehlvca des Baladles
CCRPII1TITE ETUOaTIOBS; BE1S01EBIBT I Professiona«lles, de
BI1BOBS: FBI KB | (tadldi* da Trarail et
1 de Secnrlte sod ale
1 (Carls) 3 9 («-5): 229-2*8
1
1
1C sa spies. la Tiro notification I Jattrand, B.C.
ladlcatal by lacrftase la Sl/Bv ratio, I Goal, J.
s bodies. 1 Jeanrot. I.
1 Sebastian, p.
tatieats. Prance | Bignon, J.
1 1976
SAIC*: tnes: IB TITBO »«11ISIS; IB 1 Sevne rraccalse des
ITO HllTSIS; 15BESTOS; FIBERS | Baladles Besplratolres
1 «. Stppleaeat 2:111-120
1
                                                                                                                                                                                           oo
-------
 Cobalt
tc
Itl sa.9332. n 1*93 C, tt 1100 C, TP 1 M 14 at  1910  C
TXSSfg

37M
loct*
















m,
Blood,
Mtai





















3791
Seala




















EEMSBEI toiTi

































































iHiiTicii
BETBOD
n

















US"























u





















Erases
OF C1SES


















a) 2SO
b) 260












































I1KE

•one detected

















a) lot applicable
b) lot elves






















a) lone detected
b) Cone detected
e) lone detected
d) toae detected

















fttn
RE1I | GEIIBtl IIFOKIlTIOf
j
tone detected 1 (alea
1
1 ftoa a groat of «1 aatopsiec.
1 fetea*lc aedlcal exanlnatiOBB, Japta.
I Btles, aaaa age «0. S Tr. F«aal«*,
1 taaa aae 37. < it.
1
I T1ICI SLEBEBlSt VITOFSIE5; J1P1I;
I altBiira: usnic: CIOBIUB: COBU.I:
I cncBioi; cctpnj IBOI; gncrai;
1 1ICHH; iriSKSIOB: BlIStltSE;
1 lanom: iniiont SOIOIOB:
1 SHEnn; nutim; TIBIBIOB; »K;
1 Ctlt: B»O«IH: LTTSB; KIDIEtSt
I ciimm; cnzBEUAi; BEAST; atiscLis;
1 flBCBEtS; SElIEEj IOIGS; »OH»!
1 1HILJ; COfltUKln nUBMXOIS; SSS;
1 fCBEBSIC BICICIM
1
a) lot detected I a) Kaaaaa City. (3. katl-vater area
b) 0.1«« * oc - 0.026 | b) Kaasaa City. 10. aoft-aater area
•9/1 I IlqaiflcaatlT blgber Krel [P
-- i
a) Hone detected 1 a) Bales, eacabcat, 7 sablecti
b) lone tetectad | 1) Teaalen, cetebcaa, » aablecta
O >one detected I c) Balea, ctraballai, » satjecta
d) lone detected 1 d] Fcaales, caraballaa, « »ab1act»
1
1 f coa a qtott of 61 aatopnlea.
1 taceaaic aedical axanlnatioaa, Japan.
1 Bales, aea* aqe *0.6 it. Fanalw,
1 leaa aoe 3?.* rr.
1
1 itaCE nERtttsj inofSiES; JiPii;
1 iivniit; iisniCi CIPBIOB: COBUT:
< C1ICBIJB: COfPEI] IBOf; BEICII3T:
I I»ITIB: BieiunBi BaieiiKii
1 siiBiivaj tiuiiga; nnoiWi zi«c:
i sctD; swam; irrstj nonis;
I CllEBBVl; CIIEBEU.ni. EEaBt; IVSCLES;
1 viBCTiu; SPUSE: attest town:
| BtTllS; COBPU1TITE ETIUlTICHi $!X;
I FCBEVSIC HItlCIII
1
r PISE)
nri BZECS

Takan, B.
Snialti-IaBtaoto, B.
aaano, E.
fatal. B.
WO
lech Ires of
EBTiEoiMBtal Health
35(1):3t-o










Uecanbaaa, B.I.

DUB. J.
Irnold, J.
M75
lancet
1(W1»):1008-101«

















Takava, I.
SazaU-Ianaoto, B.
leaao. K.
Teral, 1.
19BO
IrchlTaa of
loTlroanantal Health
35 (1) • M~a4












t

                                                                                                                                                                                             00
-------
Ccb.lt
7MO-W-S
Cc
l« 58.9332. » l«»3 C, BP 3100 C, ?P 1 ••  Rg  at  W10  C


















xi5soz

3793
Hir







379«
laic





1
8IPOSDEE BOOTI










IIU.TTXCIL nasn I 11101 RHR
BITHOD OF C1SES
US a) 31
b| 22











a) lot given a) 0, 16 ppn
b) lot given b) 0.23 ppn










1

1
I (
1
GFIZI1L IIPOlaiTIOR

a) learning disabled
I) controls

*tl grade stndenta in Cagnda.
cucioa; B »e SKIDS: POTISSIUH:
SCUM; C1IBIDH; COBilT; COPPBH;
ZECV: LSir; HIVGJSESZ: zzic;
CEBOinti: tiiertu; SJBCOBIT: RZTIU;
B!IB: CBJLCBM; cinot
fieriev* 24 representative
Ece~analrsis treetseats are
tatnlated. the feasibility of a
holistic, no-nash policr foz hair
analrsis is outlined and snpported.

ftTIFI; IEICI B1H JITS; III];
losmtii; ausoiSREtt SMBODS:
| 1 MMIS: PBOlSIRSs COftFlBlTITE
| I
|






I
| t

1 1
t 1
379S | |
Sail t 1
I |

1 i
I |

• i
1 1
I |

• i
• *
1 1 1
I


















































IfllDlTIOVS; ILOHmil; 1RTIROVT:
1ISZ1IC; BIBIOS; BBOSISB; C1MITC:
cuciVR; cncsiRC: CJSOKORJ COIIIT?
ccppfB: cmittr; siBBinoa.- soie;
xcoiit: IBC«: LinsMus: me;
MCHSIOH: austiisi: BSBCOBT:
(CITEBHDR; IICKZI: PHOSEBOBUS;
ECIISSI3I!: BOBIBIOS; SElniOB;
I silica*: si i TIE: SOOIOR: SIBCITIOR:
I stiFDi; in; Tninra: Ta«ssTi»;
1 IJIC; tlBCCIIOT
i
I 1 te*ie« of norld litecatare on the
1 eceninlntion and nloconcentcation of
1 selected toiic trace netals in nnnan
1 talr and nails t*l other nannnlian
1 tnir, f»r, nails, class sad boofs.
1 tstnlsted ti qeoocapklc ar««.
I tubltcts, sei, toe. exposnce
I otadient, analrses in ppn. and
I svtkoritr ttam orer *00 referanees.
1
1 iFtici: i0siiu.ii: ciiioii CMTBU
| MUICl; ZtllCPC: HDDt! E1ST; IN
| iZlUID; SOUTH IRZEIOL; SOOIBE1ST
i is»: Hint niGBOR: OTITIB STITES;
1 RIII: mis; terisw; tiriaofi;
1 iistfic; BO!o«; cioaioii: cfreeflimi;
| CCB1U; COPP1B; LEID; BIBCDBI:
I lICKZt; SZ1ZIIDR; Til: TlIlDlnii lie
| ECHUTIOf; HUH POPBHTIOS;
I eioicmraiiioii BioiiBictToss: ti»D
1 foiinTioi: PCOTiitici sxposffHE; »irrs
| fCUCTIOI; niCt SLKHTS: RR11S
1. 	
BIPZBEBCB

Plbl, B.C.
parkes, 9.
1977
1991*313) :204-20«





Chlttleboroogti. e.
I960
Science of the Total
iDl-iroosant 14:53-75

I
f














enltins, D.«.
179
Pl-SOa/4-79-049. 19*
P-



















                                                                                 (IEXT PiO!)
-------
Cebalt
7MO-*9~«
CC
It! 58.9332. OP 1«93 C. BP 3100 C, TP  1 » Tig at  1910 C
                                                                                      KOITIITOD)
TISSUE

3T9S
Be art
















3797
Kidney
















3199
Kldftef




















XPOSDBS BOBT1



























































iiimicit
RET BOD
Bl

















n

















„





















IDBCEI
OF C1SSS
1 B
b) *
















a) 19
b) 2
















a) 8
M 9
C| 12



















11 KI

) < or - 0.07 ag/q (wet
t|
) lone detected















a) < or » 0.11 Ufl/9 (vet
»t)
b) < or * O.oa ag/9 (vet
•t)














a) 0.00050-0.015 ag/q
t] 0.0007-0.032 ng/g
c) 0.0005-0.0066 09/1
vet vt


















BE»I

I 0.01 » or - 0.03
g/g |vet »t)
) Rone detected















a.) 0.01 * or - 0.03
uq/9 (tret vt)
b) 0.02 * or - 0.03
uq/q (vet vt|














a) O.OOtO nq/q
D) 0.00*1 nq/q
c) 0.0020 tq/q
let vt
leiians

















GEIZIU IIFOBIHIO*

a] Bales
t) rcules

Froi a group of *1 avtopaies.
!oceasic aedical examinations, Japan.
Kales, a«an aoe »O.S jr. leaales.
nan aoe 37. • jr.
Kl« rLEBIIlS- WOKIZS- MPII-
lIIflllDI; 1BSEBTC: CIDHIDH; COBUT;
CHORnn; ccena; iwn; sitcnaT;
IBDIHB; BlGIESIdl; ailOHESI;
tuEinna: imaoiT: scuoina:
EilEiins; Timms: MIIDIOS; zuc;
GCIO: BBOBIII: LITEH; KZDIETSi
CHIBBOB; CEJEBEIMB: HEiBT; igSCLES;
IIICBE1S; SPIIEl; 1VBSS; 10111;
BmiS; CCSP«B1TI»B E»»LtHII01S; Sir;
ECBIISIC REBICII1
a) Rales
t) resales

Pcoa a qrcnp of 61 avtopsies.
forensic *edieal esaainatlOBS. 3apan.
laics, lean aqe *0. 6 jt. Fenales,
actn aqe 31.* TT.
IBtCt dEBEITS; 1HTOPSIZS; JIP1M;
itOBims: iBsiHic; CIDHIOH; COBILT;
cEBcaiia: cciptB; IBOB: BSBCOUT;
HDIBB; 9IGI1SIDB: RllGinSS;
SqEIOIIB; HTIBOII-. SCaSBUlB;
£ii»ii»: TiTUioi: TisiDioa; ziic;
GCL1; BROHIIt; LITIE; KIDIXTS;
ClBtlBM; CltmnLOR: BIltT; BOSC1ES;
EIICBI1S: SPLEEI; IDKGS; lOBIi;
RITUS; COBPULTITE HHOITICHS; 5EI;
fCBIBSIC MtlCIBE
a) Coitcols
t) locket qccap I
c) forkec qcoap II

Kceasei caftnerr and saeltec
•cikera. ages 55-76 yr, exposed to
lea»r tetalg (-3 decades, live
tetwen cetlieient and Aeatb 0-1. 5 yr
in qroap I and 2-19 yr, qroip II.
Ccatrols. aqei »3-T2 yr, «bo lived SO
111 fcoe the factory. Svedea.
EIIDH: ClEirtSS; EIDIBTS; HfES;
tCIGSi COBPJEIIIVE EtlLUlTIOlS;
IIDOSlKlll BTGIEIZ; RilSOBEKnT
atlBODS; 41TIBOII: IBSEIIC; ClDSIiJI;
CI5HJB; cBBcnnB: COBILT; COEPII;
eciD; IBCI: iiBTBiioa; isiB;
IIDGMZSI: 1ISCOBT; f-OITBDIIDB;
iscspHoaas: EoaiBiffB: SCEBDIOB;
stiEnnt; SIITEBJ TIB; TniesiEi;
me: mini BiziBDS; IIDOSIBIII
Il»«TS; SBJITEBS; TEILtlSIOB
EEFEBSiCl

lakava. a.
Suaki-Tasoaoto. B.
IsanOr K.
Ter«i, a.
1980
Archives of
EaTiroaseatal Health
35(1):36-»«










Takava, a.
SuinM-Iasttaoto, a.
tsano, K.
Terai. a.
1980
Irchlres of
EnTiconiental aealth
35(1):3«-4W










Brane, D.
Hocdberqj G.
Jester, P.O.
1980
Science of the total
Envlroasent 16:13-35
















CIEIT P16E)
                                                                                                                                                                                              oo
                                                                                                                                                                                              vo
-------
Cctwlt
Ce
ItB 59,9332, IP t«» C. St 3190 C. It 1 » Ba it 1910 C





















IISSII



379»
llier



















3800
liwr




•
I
I

1

1

t
1
1
1
1
f
I
t


3801




i
1
1







































•

























I
1

















ZlfOSIM






































































touts tiumcu
SCTBOD


n










I

I

I
I
l
i
i
t
11







t
f
l
I

1
t
nsiSt I1BGZ BZII 1 SZlIBll IITOM1TIOB I KSKBgBCB
OF CaSZS | |
< 1
1 1
•) 7 aj 0.02-0.10 m-j/i (wet a) 0.06 * or - 0.03 1 «l Bales | taken, a.
b) 7 rt) ag/-e (»et »t) | l| fviales | samU-Iameoto. B.
b) < or • 0.09 09/9 <••* W 0.05 « or - 0.03 1 1 i«eo, I.
vt) *9/9 ('ot vt) I Fcov a 9rovp of 61 aBtopsles. i Tecal V
| fctensic cedlcal «a*i>atioiis, Jap«o. r H8»
1 e«l«s. ie«a age »0.6 IT. rciales, t Ircilrec of
1 •••» •«• JT-' tr. | I«Tirouutal Bealta
1 { 3S(1):3«-«4
I TItCB ZIHZBTS; ISTOPSIJS; JJP»«; I












a| 8 |l) 0.00050-0.15 nq/q
) 9 | b) 0.001 t-«.0*l 09/9
1 11 |c) 0.0030-0.030 19/4
1 let rt
1


i IIOBIOTS; isszBiCi cwsros: COBU.T: l
I cficmm; coprzi; IBOB; BBBCOBI; i
| IttllB; B1GIISUS; IIBCaBZSBi |
| B«t tOIBS ! aKIBOBTi SCIIBlOfl; (
l snnin: miftonj TIBUIOB; z»c: i
l ««o: BtoBifE: HTM; XIDBZTS; i
| CIIIBBO!: CZIZBBUOB; BEaBI; BBSCltS; |
l tucmsi SPIBSI : IHKS: »cin: i
| SITUS; COIMB1TITE BTUU1IOBS; S»; |
| IO11ISIC tlDICIHE |
< 1
1 1
a) 0.013 ao/g I aj Coitcols I Brtiae, o.
b) 0.012 19/9 I t) lorker grcup I I lordberg, 0.
e) 0.0095 ng/g I c| lorter qregp II I tester, P.O.
let it t 1 1980
.lediaii 1 Ceceased r*f inerr and nelter I Science of the Total
I «ortet«, *?ei 55-74 rr, expowd to | Enrlroniait 16:13-35
1 tea?r tetali 1-3 decides: Tin 1
I teteeei ceUteieit and Jeatfc 0-1.5 yr I
< ir group I »d 2-19 Tt, acovp II. I
| CdtcoK, a9<* 43-72 ft, vho llwd 50 I
1 ki froi tie factory. Sweden. I
1 1
I SfZXZB; ctlatns; riOBns; IITIB; 1
IOICS: COWaUTITE tt»101TIOIS: I
I IBDgSttllL BTfilEBS; (USBBEIZBT I
| | MTBODS; IRIBOIT; USHXC; C19BIII; I
| | C1SIBB; COMMITS: CCMIU COtttH: 1
f | GCID: 1MB: 1MTBK0B; 1X1D; 1
I I | tllUHSf; BHCOBT; BOITBBZiM: I
| | I fEOSPHOlirS; SBSIBIOB: SCKDim; 1
l i i siicnm: SIITZR: TIB; TsmssTH: i
1 1
I

u


1
1



















a) B
b| 9
a 11





















a) 0.000*0-0.013 H9/9
b) 0.00050-0.0*4 *9/9
C) 0.0020-0.0*0 Of/9
»«t M


















ZZIC: 8Z11T8 B1II1DS: IBOIStEril 1
[tins; smtzzsi tumim i
i
O 0.0016 oj/g *) Coatrol* 1 Briue, O.
b) 0.0075 a?/9 t| Vorkec qtcap I l (ordberg, a.
c) O.OOSS ag/g c) forker gtcap II I tester, ?.o.
let rt 1 1980
tediana teceased refinery aid saelter 1 Science of the Total
lockers, ages 55-74 rr, el posed to I ZgYironient 16:13-35
k«IVT netall 1-3 decades, tile 1
tcteeea cetlreient and deatt 0-1.5 yc 1
It oroip I aid 2-19 Tr, groac II. I
cotrols. ages tt-72 rr, «ho llwd SO 1
ki Iron the factorr. Sveden. 1
sstDBi: catiTzts; cioirrs: IITES; i
toias; comiiTin mioitiois: i
IRRODS: UTIBOIIj'lBSIBIC; C1DU1I1: I
cisioB: cBiontiB: COBILT; COFPIB; i
GOtC; IIOK; IIRBIIOB; Lilt); |
iiiemsi; BIBCTBI-. •otTBDima: l
ttOSfWIIIS; IVBIDIDB; SCDDIIB: t
StlNIOB; SltTEt; Til: THIGSTZB; I
IIIC-, BUI7B BalllVS; IBDISTBIU I
n ins : snintts; ttiiasian i
i
(1«M fist)
-------
Ccbllt
Cc
ItV 58.9332.
             IP 1*93 C, BP 3100 C. IT  1 m*  By  at  1910 C
                                                                                       (COrtllOED)
1ISSBI
3*02
Risele
3803
1*11
380*
Pancrea*
xposm som



1B1ITTIC11
BIT BOD
IL
n
n
BIIBBES
or cms
) «
b) 4
a) 9
b) 11
at «
b) 3
I1KI
) lone detected
) < or - 0.13 17/9 (net
t|
a) got given
b) tat 9li««
a) Bom detected
b) Bone detected
1MB | GZIZS1L IBPOIBHIOB
1
1
1
) loaa detected 1 •) Bales
) 0.04 * or - 0.06 1 t) Pennies
aa/« (net ntl 1
I fro* a qrovp of (1 antopsies,
| forensic nedical exaainations, Japan.
j Bales, aeu aoe 40.C jt. Teialas,
1 tea* aoa 31.* yr.
I II1CZ niBIBIS; 1DTOESI1S; JUaB;
| IltlBTBin; IBSEIIC; ClBBlnB; COBILT;
| CIBCnvB; CCEPIB: 1MB; HI1COBI;
| lltrog; SlSHSIOfl; BllGlBBSE;
| IOEIBIOI1; 1B1IROBT; SCIIDIUS;
1 itiEBivi: tziuioi: TiiiDios: zinc:
| CCLD: BBOIIBI: LITtI: HDBITS;
| CIIHBDB; CHEBStlOB; BUST; BUSCltS;
I I11CIE1S; SHISBi IOBGS: 10ITA;
| BIIUS: CORPM4TITS BTUOltlOIS: SSI;
1 tctnsic IICICIRI
1. - 	 	 	 	
a) 0. 07 * oc - 0.04 I •> Bonn
ppa 1 bl B*a
b) 0.0* • or - 0.03 I l«ft thnib
ppa | Ilia r«Ti«««d: knova lava 19 ot 30
Dry »t I ct*« alaaaati
1
I Baaltay 20-«0 ft olds
| ItClTS; SBT; Hits; BBTIXf; H.HBIIOH;
| IITIBOII; MSSBIC; BiSIOB; CtDHtM;
1 ciiciui; cisiOB; CHSOSIBB; COBIIT:
1 ccppn: GZBitiTiB: GOLD; IBOI: IEID;
i msiisina: uBeiBssi; BMCOBT:
| tOlIBBJIOB; BICKIl; POTlSSIOa;
| iOSIDIUB; SZUBIQ9; SH.ICOI; SIITSI;
| SOCIdl: STBQBIIOB; Til; TIlinnB;
1 IIHDIHH: XIBC: iraccsiUB
i
a) loa« datacted I at Bales
b) IOM detected I t) feiale*
1 tio* • groin of «1 aitopaiea,
j focansic aedical e»iimtioic( Japan.
I *
-------
   Cctalt
   Co

   Its  58.9332,  BP 1(93 C, BP 3100 C, TP  1 •• Hg  at 1910 C
                                                                                          (CORIItrXD)
Tissnj
3805
Spleen
















1
SXPOSOBB tomi

















1
1
BET BOO
M


















OF CASES
a) 7
b) •

















MICE
a) < or » 0.05 04/0 (vet
vt)
b) Bone detected
















BEai
a| 0.01 t or - 0.02
<>9/g (vet vt)
b) Hone detected
















6EIEBIL IEFOBB1TIOE
a) Ralu
t) Penales

Iron a groep of *I aatopsies.
forensic eedlcal examinations, Japan.
Bales, wan age so. 6 yr. Fenales,
•can age 37.* rr.

IMCE nsiiEis: inopsiES; JIPIR;
HiBinri; issERic: CIOBIDB: COBILT;
CBBOnlffSj CCFPEBi IBOB; BBECOBT;
ECBIPlil; alTIIOIt; SClBDXDBj
SUEEH3; Tiinioi: TIUDIDI: znc;
SCID; BBOBIV!; LITEB; KIDREIS;
CIBEBBBB; CEBEBEUDB; BEJIBI; RDSCIBS;
FJICBI1S; SP»tKi IUKS; lOETa;
BRais: CCIPIBITITE Efimnios: ssi:
tCBEISIC BEriCIRE

BEFEEEECI
Talwva, i.

ftaano, C.
Terai, K.
1980
archives of
Environmental Health
35(1):36-M











Ccpper
7<«0-5»-8


tt« 63.S«6. BP 1083 C, BP 2S»5 C. TP  1  u Eg at 1«28 C. 10 mm t.g at 18TO C
| TISS0E | EXPOSDtE BODTE | alllTTICIL ( BDBBIB 1 URGE i BE1E 1 GEIEMt IIMBB1TIOI
| | HETBOB OF C1SBS | 1 {
II II
II 1 1
I 3806 I US a) t a) lot 9! Ten 1 a) 0.38 07/9 vet vt I a) lorker
Idrenal | b) S b) 1.12-2.39 ag/g vet vt I b) Rot glren t) controls
glani I 1
1 I Japanese vortec. 65 re old, at
1 j etiolate FCOdociaq plant foe 30 jr.
f 1 1 f tied of •axillary aod lung cancer.
II j | Ccatrols, ^9-78 jr old.
1 i 1
ill I JIFU; JDIPOEB TISSUE: IOBIA; SORE
III! I Bltaoi; BEJII; CfBEaEllVH; CZSEEBHII;
III 1 Kllins; IlfTB; LtTRCS; EUSCLES;
III I EiiCBEis; sin; cnonuB; COFFEE:
I
1
1
i
3807 1 1 1* 2
lorta 1 1
t 1 '




























































1
< or * 2.1 ag/g (vet vt) 1.2 + or - 1.7 ug/g

















(vet vtj
















EIT1LS; !I«C; IIDOSIBUL PtlHTS;
IIMIaTIOl; CCCDPITIOI1L B1ZJS3S:
tcenttTioi tmsniE

tales

Fro • a grogc of 61 aatopsies.
foreosic aedical exallDfttiansr Japan.
Blles^ eean age 40.6 rr. Peiales,
••an aqe 37.* Tr.

1I1CZ EHHITS; aUTOPSISS: JlFtl;
IICBIKD1; ISSEEIC; CIDami; COBUT;
cBEcsrns: CCPPEB: IBOI: IEBCHBT;
IlttVI: B16IESHB; BlIClRISt;
EDilDIDS; HIIHOIT: SCIVOIOB:
SIIEHDI; TIIIEIOI; HMDID5! ZIIC;
«C1D; aiOPIIII; UTEB; KIDR'TS;
CHZB839: CZEEBELLItB: BIIET; BUSCLES;
tllCBtlS; SPIEEI; LUGS; 10BI1;
iniLS: COIP1UTITE ITflOaTIOIS: S!I;
TCIIKSIC HIC1CIIS
BZFEB3ECE



Fjodo, I.
SazoW. s.
Fnrnya, H.
Beshizaka, K.
1»BO
International archives
of Occupational and
Environmental Bealtb
•6:1«1-1SO







Tnkava, S.
Snzoki-Tasuaoto, g.
Inano, S.
Terai, B.
1980
Irckires of
EnTicoDaentsl Health
35(1):36-4«










(HIT PIG!)
                                                                                                                                                                                              VO
                                                                                                                                                                                              ro
-------
per
0-50-8
• 63.516, IP 1083 C, BP 2595 C. TP 1 » Bg at 1628 C, 10 an Bg at 1870 C
(COITIIVZD)
T.ISSI!



3808
aorta















3809
Blood,
semn













3810
Blood.
sersa












3811
Blood.
ceres









IPOSOBE BOOT!




































Ingestion














Ingestion











Murricti
BF/TBOD


US



























































BOBBEB
OF C»SBS


) 1
1 5















28















2


























B1TCS *E1B 1 01 II Ml I1FOB81TIOB
|
1-
1
lot given a| 1.01 ag/g vet »t I a) lorker
0.56-1, »3 ug/g set *t b) lot given 1 M controls
1
I Japanese nortec, S5 vr old. at
j chreeate crodncing plant for 30 yr.
1 tied of saiillart and lung cancer.
1 Controls, 59-71 it old.
1
1 Jifai: iDiposE TISSUE: IOBI*; BOBB
| BlBtOB; IB ill; CIBEBKLIOT; CZBEiBOB;
) K1B1IYS; 1ITES: LSBSS: HHSCIES;






a) lot give*
t) lot given
c) lot given
d) lot given












a) lot given
b) (ot given
c) lot given
d) lot given
e) lot given
f) lot givei
g) lot given




















I MicBtis: SHI; cHBosioa: cansii
1 (IT IIS; me; I1DUSI3IU. PUBTS;
| 1IB1LITIO"; CCCBPITIOIIL BallBDS;
| tCiaUIIOB I1POSOBB
1
1
a) 166.6 t or - 7.95 1 a) 18 pellagiins
a 11 no old. hospital day 1*
f) 108 ag/dl I ft 11 no old, hospital dav 17
g) 105 ag/dl | g) 11 no old, hospital dav *S
1 Cn adnisslon levels belov detection.
1 then given 3.5 eg/dav
I Ccpper-deficieint children.
1
1 C1SE BISTOBIIS; CHIIDSB"; XISBtSES;
t B1IB; COP?IB: BBIILS: 2HC
1
1
1 levlev. Profile of healthy snblects
1 lastline data for deternining change
I it nutritional status from Industrie
I fcoA proceasieg tecfcnigaes.
1
I in 2tniic: »so its: rimst KFMTS;
I I100B 5!BUR; BIIB; KIOIBIS; IIT1B;
1 Bill; «£Vin; OIRS; FOODS; SOUS;
1 vlGRHIOt; CIDBTOB: COPPEB;
] BIBGIVISE; milS; TBtCE E1EBBITS;
| ZIBC
1
IBFIBBBCI



lyodo, K.
Sunk!, 5.
FDrnva, 1.
Beshiznlta, X.
1980
International archives
of Occupational and
Bavironiental Health
a«:1»1-150








Krlshnasacaaci ,
K.t.V.S.
117*
aserlcan Journal of
Clinical Butrition
27:108-111










Bradfield, K.B.
Cordano. 1.
Baertl, 3.
Erahae, G.6.
1980
lancet 2(8190) :3«3-3«









GnthrLe, B.B.
Bobinson, n.r.
1978
>e» Zealand Bedical
Joornal 87(603):3-6







(BEIT P«GE|
-------
Ccppac
74*0-50-8
Cl
It* 6X5*6, BP 1083 C, BP 2595 C. TP  1 ••
                                             at  1628 C.  10 » 89 at 1870 C



















IISSIB

3812
Blood,
seraa










1
|
1
1
1
1




3813
Blood.
sera a

KPOSBBB BOOTS













1
1
1
|







1ULYTIC11 BOa-BIB | BaBGB IBal | GBIIBIL IIPOBBaTIOB
BFTBOD OF CISSS I |
	 1 1
1 1
US a) 2«0 | a) lot given a) 1*4.60 » or - 3.95 | a) Kansas city, KS. hard-vater area
b) 260 | b) lot jivea ag/100 si | t) Kaasas City. SO, (oft-vater area
I b) 172.1* * or - «.7S | Significantly kigker level in
1 ag/100 al I aoft-iater area.
1 1
1 I IS and 8O residents aatened for age
1 1 (aean ages 37 and 37.7 yr). sex,
I | lengtk of resldeao*. narital and
I | econoaic statas. occipation, amber
| | ef cklldrea, saokiag kablta. bt, it.
I 1 IB kard-vat«r area, significant
1 1 increase in hypertension. ECG I
I 1 abnormalities, and kypernrieeaia. 1
1 1 1
| | 111315; BIS5COEI; 1DO1TS; |
| | CatDICTlSCDXll BISE1SBS; |
| | BIPBBtXlSIOl; B1OOD SBBDB; |
I I CC8P1I1TIVB IValUTJOBS: C1DBIVB; I
| | C11CIKB; CfllCBIOH; IITBIOB; I
I I I1SBESID8: PB05PBOBOBS; POT1SSIOB; I
1 I soDins; MIC; BIOICCDIOIITIOB: i
I t DfiiniG IIIIB i
i ii
I i i
IIS a) 15 j a) Bot givea a) 168 » or - 38 I a) Ben, lov tlood pressure i
BIPBBXICB

Blerenbans, fl. 1*
rielscksan. 1.1
Dnnn , J.
arnold, J.
1975
lancet
1(1914)5 1008-1016
















BcKenzie, J.B.
1 b) 17 | b) sot given ag/al I e) lea. kigk blocd pressure | 6atkrle,~ B.B.
1

c) 19 |c) Bot givea b) 1S9 * or - 19 I c) loien. lot blood pressure | Prior. I.a.H.
d) IS 1 d) Bot givea ng/ul I d) loaea. fcigh blood presaare 1
1978
1 c) 179 « or - 30 I Subjects selected by blood pressure I laerican Journal of
1 oq/al 1 rank froa a previous study. I clinical Butrition
1 d) 172 » or - 27 I Iftlaated daily intake, 1.5 ag. 1 31:*22-*28

1
1
1
1
1
1
1
1 1
1
1
1




|
|
1
1
|
1
I
1
1 381* lagestioa 1
1 Blood,
1 saroa |
1 1
1 1
1 1
1 1
1










38 IS
lone
•arrov























1
1
1
1
1
I
I


















....
1 ug/al | f
1 I Fclyaesian residents of Tokelau |
1 Islands, croided conditions, I
1 satsistence ecoaoay. Ben, aeaa age I
1 «! yr. »«an kt 167 ca, nean it 7* kg. 1
| Icnan, sean age 46 yr, nean kt 165 j
j en, lean vt 79 kg. j
1 1
I CCCPIR; ZI1C: BIOOD SBBOB; BAIB; I
1 I | MILS; B1III; I» ZfttllD |
II II 1
II II 1
1 a) 12 I a) Bot givea
1 b) 10
1 c) «














US
d) 7
•) 11
f) 8
g) '
a) 7










«) 1
b) S














b) Bot given
c) Bot given
d) Bot given
e) Bot given
f) lot given
g) not given
h) lot given










a) Bot givea
b) 0.32-1.07 ag/g vet it













..












a) *2.8 ug/dl I a) Baseline data, at age IS * or - 1 Hillnao. L.S.
b) 46.4 ug/dl | (.3 days I Bart in, 1.
e) 58 ng/dl | r) 4 vk | ri
ore. B.
d) 73.6 ug/dl 1 c) 9 vk I 1981
e) 35.3 ug/dl f d) 12 vk I Journal of Pediatrics
f) 40.9 gg/dl I e) Baseline data, at age 17 » or - I 98(2): 311-313
g) 54.3 ng/dl | 7.0 days j
h) 63.9 ng/dl | f) 4 vk |
1 9) 9 vk |
1 «) 12 ik |
1 Creaatare infants fed foraula I
1 ccntaining 1.67 eg/1 cu (a-d) or 0.4 1
1 ag/1 Cu le-k) |
1 1
I nrirrs; BICCD SIBOB: COPPKB; DIETS; i
| BII1IS |
i i













a) 0.82 ag/g vet vt I a) lorker I Byodo, I.
b) lot given I b) Controls I Suzuki. S.
1 1 Furuya. B.
1 Japaaese uorkec, 65 yr old, at 1 Keskiznka. K.
I ceronate) trcdaciag plant for 30 yr. I 1980
1 lied of nazillnry and lung cancer. 1 International ircaives
1 Ccatrols. 99-78 yr old. I of
Occupational and
1 1 SnvironMBtal Health
1 Jlfll; IDIPOS! TISSDB; »OB1a; SO1B | 46:141-150
| B1BBOU; Btlll; CI1BBBL10B; CIBBfSOB; I
| KIIIITS; ll»n; LOIGS; BOSCIZS; |
| (IBCBZaS: SKll: CBtoniTl: COtPIB; |
| BI111S; HBCt 1IDDSTH1L P1HTS; I
1 iiBiiiiioi: cccumioitt BIIUDS; i
1 fCTVUTIOl IIPOSaBK I
^ \







                                                                                                                                                                                          VO
-------
Ccpper
7MO-50-8
C«
III «3.S«6, IP 1083 C, BP 2S95 C, TP  1 aa Sg at  t628 C,  10  •• (9 at 1870 C
                                                                                      (COITIIDSD)
I tISSVZ
1
3816
Brain
3817
train
3118
Iraia
3819
Brail
KFOSB8I toitl




nitmcu
1ST BCD
1
US
IIS
us
VIM EH
OF C1SSS


a) 8
b) *
Cl 10
3
MieS
) 2.4-12 sg/g |Mt vt)
| ».5-1» qg/g fvejt vt)
I 1.7-6.5 ag/g (vet vt)
I 2.3-7.2 99/9 (Mt lit)
a) lot given
b) lot git««
e) 2.42-4. 19 ag/g vet it
a) lot given
•) lot giT«
a) 2.1 3-4. 6C ug/g
b) 3.26-4.09 ag/g
c) 2.55-4. 20 «g/g
let it
a) lot given
b) lot gi*»
c) lot given
d) lot given
•) lot Jinn
f) lot given
mi i GIIIMI iiroiuTioi
I
i
) 6.0 » or - 4.1 I a) Bales, cexebtan. 1 subjects
g/g (vet vt) | 1) Peaales, cerebraa, 2 sabjects
) 9.3 * or - 6.7 | c) Bales, cetebellaa. 7 subjects
g/g (wet vt) 1 o) Peaales. cerobellaa. 5 sebjects
) 4.3 * or - 1.S |
og/g (vet vt) 1 ftoa a groep of «1 aitopsiea,
) 5.5 » or - 2.0 | forensic aealeal exaaliatioc*. Japan.
g/g (vet vt) I gales. Man age »0.6 re. Teules.
1 ««a» age 37.* yr.
1
1 II1CI niaillS; aOTOPSXBS; JlPlI;
1 unniioa; Hsmc; CIDBIOB; COBUT;
I cnonni: CCIPII: nci; HICOBI;
I iitioa: HiGiisina; iiiGaiisi:
i stsiDius-, unaoiT; SCMDIDI;
1 Eiiniai; Tiiiiioi: wiiDini; znc:
1 GCIC: BBOBJII: titiB: KIDHIS;
I cntBtni; cHiBEima; BUST; ansciis;
1 I licit IS; spmi; iotas; loill:
| IRUS; COHPU1TITE ITILUITIOJS; SIX;
| ICI1ISIC SIDICIIB
1
1
a) 4.11 ug/g 1 a) Vorke>r - oarebrva (temporal)
b) «.2S 09/4 1 b) locket - eerebrua (occipital)
c) lot gi*en 1 e) S coatrcli - cer«brt» (frontal)
d) S.03 ag/g I a) lortor - cerebellui
e) 3.58 ag/g 1 c) Coatrol - cerebellii
let vt |
1 Jafanem voEtor. 65 ji old. at
1 caroaate Erodociog plant for 30 yr.
I tiad of aazlllary aafl lang caacer.
I Ccatrola, £9-78 rr old.
I OKU; iBiposi TISSOI: toaii: BOIK
I guioi; EJiii; cnEBnim; CZEIEBOH:
1 JICIETS; HTn; mss; ausciIS;
| CllCIltS; Sill; CBBOnOI; CCfPEB;
I BRILS; IIIC; IIDISTBIal PlaRS;
| 11B>I»ICI: CCCDPUIOIIL BIZUDS;
| tOttnaHOI IIMSOBB
1
a) 3.23 ag/g I •) City reiideats. lover flacrs
b) 3. SI ag/g 1 E) City residents, apper floors
c) 3.50 ag/g 1 c) Sabarbs and Tillage residents
let vt I l«s«tli« correlatioa (P < 0.05)
Hedians I cttveea orgaaic Pb aad ca.
1 litopslea. Resideats of Copenhagen,
1 Its suburbs, and of Tillages on
1 Haland. ages 12-S« yr.
1
I CtlHHK; 10D1TS; IOTOPSIBS; CBI1DBH
1 imii IXB PCHOTIOI;
1 cicaccnioiinoi: nan IBEIS: L»D
1 CISIIIC CO»C0IDS
1
a) S25.8 * or - 3«.8 I a) Slobns pallidvs. 11 sanples,
niol/g | cceffieleit ef Taciation (CT) 21. 91!
b) 659. 1 * or - 2».» I b) Caadate noclens, 11 sasples. CT
mol/g I 12.3*
c) 7>2.< « or - 17.6 | c) Pntaaen, 12 staples, CT 7.9Y
naol/g j d) Sabstaatia nigra, C sanples, CT
d) 1139.8 » or - 66.3 | 11.2V
aaol/g | e) Cerebral cortex, 19 sanples, CT
e) «95.4 * or - 22.8 I iO.1t
aaol/g I f) lippoeaapas, 13 staples, CT 19.21
f) »25.1 » or - 22.7 I
naol/g I Ktopsy saitlas
Dry vt I
SB | CHZBIal CCBTEX; REISOBSHXIT HBTBDDS
I ciiciiH; copcBB: noi: meinsi:
1 i»n: mopsxis
UfSIZICB
akava, 8.
oiokl-Tasnaoto, B.
naao, K.
Terai. 8.
980
rcniTes of
•Tironneatal Bealtn
S(1):36-««
flyodo, K.
S«aki, S.
Paroya, 1.
•esbizuka. K.
1980
Intematioaal IccaiTes
of Occapational aad
Enviroaneatal Health
»6:1»1-1SO
lielsen. 1.
Jensen, K.I.
Grandjean. P.
1971
latare
273(5671) :602-603
Goldberg, 9.3.
lllen. I.
1981
Clinical Cheaistn
27 (»): 562-56*
                                                                                                                                                                                              vo
                                                                                        (IBXT
-------
Ccfptr
C«
lt> 63. 5«6, tt 10*3 C. BP 259S C, tP  1 •• Hg at  1«2B C,  10 aa Eg at 1870 C
























flSSfff



3*20
tnatk











3821
Bafr




1
1 1
1
1
1
1
1
3S22
Stir
1

1
1
r
i i
i
i



3823
flair
1
1
1 l
< 1
1 1
1 1
1 1
l l
t











M2»
Halt



















ZTfiOSORZ 8O9TZ UllTClClli lOBBtt BalGI
HRBQD OP CaSBS


laaalatlaa PIZE 1 lot linn






1





a] 8
b) 10





I

1

1
1
1 US a) 31
t »| 22







a) lot giro
b) lot gi»«n










mi i CFKUL nroiBuioi i sznnicz
i i
i i
i i
3.8 ag f t I *aapl«d at rat* of 1 I/air, 2-10 I Mtnlnoi, E.E.
I vie aftec batalbg 4 ace v*14lB9 C9d*. \ D«aa«d«l*«Cv G.&«
1 I Joaaaaaon* T.S.
I rilvaralty pljalBB a bop, Florida I Uaeaaater, J-»-
1 1 "7S
1 IIOJIDI; units; B8X1H; CilClOB: | Inaala of occupational
I cnoiIlB; CIBOKOS; COPPZ1; ItOI; | Byglan* 1»:22S-23»
I mi: Baieiiisz: ncm; POCISSIOB; i
l sotroa, iirniiTB: Tiiirijni; ate-, in i
1 M1IOTJOP; TOBSS; mnsnial 1
| 11BOSPBE11S: tBaCZ ZIEBIIS I
i r
1 t
a| IS. 6 * or - 1.73 | a) Pclla-griai | Kr iebmaachiri .
ag/g 1 t) BealtVr »Uont»ac» 1 x.l.r.H.
b) 8,7 * or - O.S7 | | 19T«
ag/g 1 todaaic pvllaoclaa, 16-60 ji old and I laerlcaa Joacaal of
1 b«altar *al«« oocloccoaoalcallr 1 clinical latrition
1 uteita to rillagciaa. I 27:tO»-111
1 1
1 CCPPfl; BX111S; H1EB11 RZtlBOtlSI; (
1 CISZISBS; HEta; BIOOS SEEDS; BITIZ; t
i sui irszasis; inic icias: BUI: i
1 CCBPMI1IVI (VUDITI} t? fft l tj Cettiali I Parkw, 1.
1 1 1«7T
1 laanlaa fllaiblad utf soraal Jit «ad l scluc*
1 att arad* stadant* 1* Canada. I 1»Bfa313) s20»-2O6
1 1
1 cucin; siGiJsios: wmssioB; i
I SCtlOU: caDBItM; OOBILT; const; |
| 1(0 f; IMC; MISMSSX: ZI«C; |
t i cticiTM} imttrts matt; HETIIS; i
I 1 Bill; CBIUBEl: CaMDl |
1 1 1
1 1 1
1 1 E«»i«». 24 c*pnw*atati» I cbittlwbocoagli, B.
I | F>*^analy9ia tcvatatats arc I 1980
1 I tatolatad. tta fcaalbilltr of a I scl«ce of the Total
1 | 1 tells tic. ao-*ash policy foe oair I MTlrooaoat H:33-73
1 1
1 1
1 1
1 1
f
j
1






















1ST








.












1























8.58-15.09 ng/g








- -
1 aDalyals la cvtllacd and sapportod. |
4 1
I fITIZI: TB1CI B1E1EBTS; Bilk; I
1 icsttiiH: ausgizBcn iRBors: i
i fiins; PROIH»SJ ccipuitm i
1 ITJtmtlOIS; 1IBBTIDS; HIIBCn; I
I JPSZdC; B1BIUB; BEOKK; C1IBIOB; I
j c»icn
-------
ccpper
Co
It* 63.5(6, IP 1083 C, BP 2595 C. TP 1 •« Eg at 1C28 C. 10 II  Bg  at  1870  C
                                                                                      (COITIIUKD)
1I3SDI

3*25
lair














•sane
4a«O
lair

















3827
Bait












BIFOSms 10011


















































nunicu
OTBCD
US


































It













HJBBSS
or CISBS
3















»t ^A
1 Jo
b) 2«
0 37
S) 28
a) 16
f) 19













a) 23
b) 19
c) «2
1) 11
e) 26
f) 10








11IGI

) Rot applicable
) lot applicable
) lot applicable
) lot applicable
) 11-35 ng/g
) 1«-68 04/9
) 11-28 ag/g
) 13-39 ag/g
) 16-27 119/9








0 lot given
c) lot given
d) lot given
e) lot given
f) lot given













a) «-10» ug/g
b) 10-2*5 og/g
c) 1-215 ug/g
d) «-35 ag/g
e) 6-»3 aj/g
f) *-»3 ag/g








mi

) 36 «g/g
) 13 09/9
O 56 ag/g
fl) 22 ag/g
«) 19 * or - 7 ng/g
f) 29 * or - 11 ag/g
g) 21 » or - 6 09/9
h) 25 • oc - 11 ag/g
i) 21 * or - 3 ng/g








ag/g
b) 11.0 * or - 1.8
ag/g
c) 10.2 « ot - 1.7
ag/g
d) 28. 5 t or - 4.7
ng/g
e) 31. S t or - «.«
«g/g
C) 20.8 t or - 7.8
ag/g







a) 22 ug/g
b) 59 ag/g
c) 29 ng/g
*1 7 ag/g
e) 10 ug/g
f) 9 ag/g
Medians







eiiiiiL iirosaaiioi

) 10 ao old patient, o& admission
) 11 >o old patient. OB adBission
) 10 BO old, recovered
) 11 BO old recovered
•) 11 COBtColS
f) K Kvaahicrkot patients, on
adiissioi
g) S I»a»hioi!tot patients, xecoveted
i) 1* gatasau patiartl, 01 adnisaion
.) 9 aaiaaint patients, tvconred
Cepper-deficievt 10- and 11 BO olds.
loraal eciticls, aad negative
ccatrols with Hataaana aad
liaahiottot.
C1SI HISTOSIIS: CBIID5II; DISUSES:
mi; COFPII; mils: zuc

b) Tall-ten Ion blrtkveigkt, at
blrtt
c) Pce-tera, at birth
d) Controls, 3 BO
e) Fnll-tera lo« birtaveigbt, 3 BO
f) fre-tert, 3 BO
g«diaas « 01 - si

leoaates in Halifax. Pre-tera gxoap
lean bicthieigkt 1880 g, 26-36 t\
geatatloa, foil-ten lov birth«
-------
CCppar
7M 0-50-1
Cl
Itl C3.SW, I* 1083 C, BP 259S  C,  TP 1 aa Eg »t 1628 C. 10 »  Bg at  1879 C
                                                                                       fCOITIIllCD)



























IISSDS


38 28
Bait















iiMsnts tons






















IIIIRXCIX
RCTBOD
























•3*ea
OF CIS!
























1
1 3B2» I rng«cion us i ai is
I late t 1 b) 17
l| C) 19
It 1 « 15
( 1 i
1 1 1
1 1 1
1
I


1
1 1
1 1
1 1 1

.1 1
1 .........
1
3139 U a) *
(«rt


1
( I
1 I
t






























«>) 2


















IIICB mi i SEiim iiroBRirio*

i
1 1 rc*i« of rarld lltaratar* os tie
I accaavlatioa and bloe>ac*atratioa of
1 acleetad toxic tcac* aatalx la bnaaii
1 atic *>it nil* aad oth«r aaanllaa
1 tali, foe, aiils, clara aed tools.
1 Tatalat«d JIT geographic area.
1 1 «i61«ct», MX. to*. *xpo*ar«.
I | ozadiaat, aaalra** IB ppav and
I 1 attaorltr tret orcr »»0 raf«r«so««.
1 1
I | micii IDSIUtUj C1UD1; CIIT1U
I i «§i»ict: IOBCPB: u»nz nsi; in
I i iiuiu: SOOIB unict; somnin i











1 Vot flTCI
1 *>t «1T«>
lot gl»«
lot jt»««















*| < or « 4.3 «?/9 (nt
•t)
b) 2.<-6.9 «9/J (wt >t)

















I 1511; OIIIJI KII600I; DRTIO STUBS: t
1 aui; iiii5: BifiEt: imioii: i
1 1BSHIC: BOBC»; C1B5IUB; CH08IJB: 1
1 CCI11T; COPPlt: 1111; BISCUIT: |
1 11CIF1; SB1E1IHB; til; Tllllloa; III I
1 icimioi: itiHu paraiinois; t
1 iioiccaamiioi; BIOIIDICIIOIS; HID i
1 foiiBnoi; pcromioi CTPOSOIB; »*T«B i
1 (cuonoi: tuct nimis; anus i
J i
l i
vi/q I t) ••>. klgk blocd (t*<»t« I
b! 10. a t 01 - «o/o | e) IOMI, Ion blooj pr«ssut« |
c| ID. t + or - 3.0 | o) IOHI, klgi blood preside* j
M/7 | £otj«cts Mlacted by blood pnaxur* I
4) 14.8 • or - 2.3 I tait fro> a tnvloM atodf . I
•9/9 1 I*tlaat«d dallr iitaln, 1.5 ag. I
1 I
j felTiaslan tasldamta of To»«lao I
j Iclaida, eroidad eoidltlona, I
I Mtslstoac* «CODO«T. B»n, vaai aq« |
1 «5 tr, aaan bt 167 ca. Man «t T* kg. |
1 Icaca, Man ag« »6 ir, *«ai at 16S I
I em, a<» at 79 kg. I
1 1
I ccppia: sue: BIOOO SEBOS; HIIB: i
l mis; »i»: IM ZBUIID (
i i

BZFBBZBCI


Jeakias, B.I.
1979
BPl-«00/»-79-M9, IBt
pp.




















BcRaazla, J«R.
Gitkria, B.I.
Ftiox, 1. 1. 8.
1S78
laerican Journal of
cHaical latrltloi
31:«J2-«28












a) 2. » » or - 1.8 I a) Balas I Tokav*. a.
»9/J («*t »t) t| reaalM f E
J» «. 8 • or - 3.9 t 1
azafci-Iasaaoto. a.
aamo. K.
ng/g (»et »t) Proa a gco«i of 61 avtopclas, 1 Taral. R.
fonasic aadieal vxaalaatlou, Japaa. 1 1984
Bal«s, a*at age *«.« yt. r«aal«s, f 1
ccnlTei of
a*a> a«a 37.1 rr. I EmrironMiital Baaltt
1 3!
1I1CI 1LIBIITS; HTTOPS1ES: Jlfll; t
atORIIil: llSniC; CIDBIII; COB1LI; f
cnoBios: CCCKI; IBOI; aiBctrar; i
IltlM: llGIBIBB; UieilZSB; |
iOtlDHI; IITIIOIT; SCHBina; (
stmria; tnuiai; tiiioina: •Jisc; i
GCID; B10BIII; UCTEB; KIDIBTS; I
ciiEBBii: ciimiua; BUST: lasctES; i
CIKBBIS; SPIUI; LUIGS: 10ST1: 1
aitus; coirumn iriivincis; ssi: i
rcmsic Biticiii i
i i
(«tii Pie i)
>
-------
7MO-50-8
Ct
lt» 6J.5«6.
            IP 1083 C.  St 2595 C, TP 1 •• Bg it 1628 C. 10 •• Sg at 1870 C
                                                                                     (COBtlHEV)
HSSIt
3831
Kidney
3832
Kidney
3833
Kiaaey
EIPOSOBI BOVTX



iBixYTicu
RTBOB
u
us
n
•0IB8B
or cisss
) «
) 2
«) 1
b) 5
a) 8
b) 9
CJ 12
S1BSB
J 1.5-3.8 ag/g (»«t wt)
) 1.«-3.0 og/g I 1.07-1.19 ag/g
b) 0.89-3.72 «g/g
C) 0.82-3.58 ag/g
Bet «
iui | eiiiiti. iirosufioi I MPIBBBCB
i i 	
1 1
a) 2.5 » or - 1.1 1 a) Bales I Takana, S.
ng/g (»«t »t) 1 t) resales 1 Sazati-lasnaoto, a.
b) 2.2 + or - 1.1 1 1 »»aao. «•
ag/g (»et rt) 1 Hoi a groap of 61 utopsies. 1 T«rai. B.
I forensic ndieal ezaaliatioas, Japan. I 1910
I Bales, Ma» ao* ao.6 yr. P«aal«s, 1 IrchlTM of
1 a«a« am 37.* jr. \ Intitouutal Malth
I 1 35(1):3«-«*
1 nici niBiiis: lOTOPSixs; juai: i
i iiciimB: iisnic: CIBHOH; COBU.T: i
| CIBOBTDl; COFPBB; IIOI; BIBCDBt; 1
1 IltCTB: BKHSXHB; BiIMlISI; 1
I ItHIVira; 1BIXBOBT; sciiDIOl; I
1 siimus: mum; TIKDIDB; sue; i
| CCLD; B10RIBB; 1ITB1; EIDBZ1S; 1
I ctBiBira: cntBitittB: BSiBi; anscLiS; i
I FMCB113: SftESIi LOBGS: ICSTl: 1
1 iittts; coiiniTin BTiLoitiois; SET; i
1 ICBHSIC IICICIII 1
1 1
1 1
a) 1,«9 ng/g »«t vt | a) lork«r 1 Bjodo, K.
b) «ot givei | k> Co«trola 1 Somki. S.
1 I Tncnra, S.
I jaiaHi* «ott«E. «5 TE old. at 1 Beskliaka. K.
I cttoaata (ceaaelag plaat foe 30 TE. 1 19SO
1 tied of •axillary aid long cucnr. 1 International irchlTos
I Ceatrols, 59-78 jr old. 1 of Occapational and
1 | iBTtCOBMatal Baalth
I J»II; IDIPOSt TISSOB; IOBT1; Bon I «6:1«1-150
1 iiBim; BSIIB; CIIBBELLOB; CZBBIIOB; i
1 KIBIITS: 1ITEB; lOIGS; HUSCLIS; |
| I1BCBB1S: SKU: CBBOnOH; CCIfSS; I
| BFtltS; ZIBC; IBOOSnilL PlllTS-. I
1 IIBIUTIOB; CCCBFlflOIU, HIZHDS; 1
I fCPOIlTIOI IIKSDBB 1
1 • 	
	 1 1
a) 1.57 «g/g | a) coatcoli 1 Brrae, B.
b) t.6« «g/g | t) Iock«r gteap I 1 BoEdbeEg, C.
ol 1.66 ng/g | c) «ork«r qcoip It 1 s«st«r, P.O.
let it 1 1 1'80
Rediaas I C«c«as«4 rofisorr and Melt.r 1 Science of the Total
| •cikacs. ag«> 55-76 TE. exposed to 1 InTitoaaent 16:13-35
I k«a*T tetali 1-3 decades. Tiaa 1
1 tctveea Eetlteaeat and deata 0-1. S yr 1
1 la groip t aad 2-19 TE. groap II> 1
| ccattola, agas »3-72 yr, »»o ll»ed 50 1
j ka fro a the factory. Svedea. 1
I jiiDii: ciBaTEBS: mo«TS: LITIB; I
I miss: coMitmn iTiiniTiois; I
1 lltBSTBIll BTGIBIB; BIISUIIBIBT 1
1 (HMDS; 1RHOBT: 1BS1SIC: C1BHOB: I
I CISlnfl: CBICRIDH; COB11T; COJPEB; I
i «c»: HOB: itKBMW: LEID; |
t BIICIIISI; BZBCOBT: BOLTBDHOR; 1
1 IBCSPHOSOS; BDBIDIOB; SC1BDIDB; 1
| SZ1ZII1M: SJ1TCT; TI»: THIGSTJB; |
1 IIIC: BBIItB H121SBS; IIODSTBIll 1
| tllBTS; SBtHEBS; miBBIUH |
1 	 1 	
                                                                                             net)
-------
ccpper
74.40-SC-8
Co
»« 63.546, IIP 1083 C,
                       BP  259S C,  TP 1 •• Hg at 1628 C, 10 ••  fg  at  1870 C
                                                                                       (CORIRBED)
1
1
1
1
1
1
1
1ISSO! BIPOSIJBZ tODlS ASAIYTICA1 B0BBZB
HETHOD Of C1SI.
383* U a) 10
liver b) 3
1
I
1
1
1
1
1
3835 1 US
line \
1
1
1
1 1
1
1
1
1
1
1
1 1
1 I
3836
line
i
1
1
3837
lifer
I
»
»
f
1
1
Ingestion
»
1
1 M
1
4
«
«> 1
1 b) 5
1
a) 8
b) 9
c) 11

I1IGX
>
a) 3.9-38 09/9 <«»t vt)
b) 3.0-8.2 ag/g (net vt)
a) lot given
b) 1.16-10.20 ug/g vet vt
1
1
a) 1.44-6.9C og/g 1
b) 1.30-5.2* ag/g
c) 1.38-5.52 og/g
let vt

BXAI | GZIIB1L IlfOHBlTIOl | BSFS8ERCZ
1 1
1 1
1 1
a) 16 » or - 12 og/g I » Hales I mkava. 9.
(vet vt) | I) Females | Snznki-Iasnioto, B.
b) 5. 9 » or - 2.« 1 1 Amano, K.
ng/g (vet vt} 1 From a gromp of 61 autopsies, I Terai, B.
I forensic lexical examinations, Japan. I 1980
j Bales, lean age 40.6 jr. Feaales, I Archives of
I lean age 37.4 vr. I Environmental Health
1 1 35(1):3«-44
| TBACE BLIMBITS; AUTOPSIES; JJPA5; |
| AIOsImTJg; ABSEIIC; C1DHIOH: CO BUT; |
| CBROHIUS; COEPBB; IBO»; HBBCORI; |
1 UDmn: aiciEsioB; uxsarxsz; i
I IOEIEIII1I; 1III8OIT: SCAHDIUS; |
1 siLEiins: iiiMios; Tinoioi: ziitc: i
I SCH: BSOBIIE; LITEB; KID1XI5; |
t ClSnimi; CHEBE11UB: BK1BI; IDSCLES; 1
| FIBCBB1S; SFIEXI; tDIGS; 1CBIJ; |
| BIT1LS; COHFUITITZ BTltUiTJOKS; SET; I
| FGBEISIC SICICIHE I
1 1
a) 4.26 ng/g vet vt 1 <) worker 1 Sjoia. f.
b) lot given 1 t) Controls I Suzuki, S.
I I FuruTa, H.
| Japanese vorkec, 65 Tr old, at I Heshliola, K.
I cntoeattt Fccdocing plant for 30 yr. I 1980
1 Cied of •axillary and long cancer. I International Archives
I Ccatrols, S9-7A yr old. I of Occupational and
I 1 EnTlronieatal Health
| JAEAI; ADIPOSE TISSUE: AOBTA: BORE I 46:141-150
I B1BBOB; EBAII; CEBEBELLBB: CEBIEBOI; 1
I KICIIIS; IITfS; LUBGS; BOSCIES; |
I fllCBEAS; SKIS; CBEOBlaH; COIPEB: I
| BETAISJ ZIIC; IBOHSTBIU PIABTS; |
I I1BAIATIOB; CCCBPSTIOKJ1 B1Z18DS; I
I ECPOIiTICli UPOSOBB I
1 1
1 1
a) 3.59 ag/g 1 a) Control! 1 Brune. D.
b) 2.91 ug/g I t) socket gtcap I 1 Koraberg, C.
c) 3.08 ag/g 1 c) socket group II j tester, F.O.
Ret vt 1 I 1980
Medians | Ceceased refinery and saelter I Science of the Total
1 vcrkers, aqes 55-76 TT, exposed to j Environment 16:13-35
1 betvaen retirement and death 0-1. 5 rr 1
I in group I and 2-19 rr, group II. 1
1 Centrals, ages 43-72 re, vbo lived 50 1
1 ki ftoi the factory. Sveden. 1
1 1
1 SfECZB; C1DATZRS: KIDIET5; IIT5B; I
| I DIGS; COBPIBATIVB BTA1UATIOIS; |
I IIEOST8IAL BTSIEIB; HXASOXEaEMT I
I BITBODS; ARIIOII; 1BS1IIC; CADBIUB: 1
I CISIOR; C BBC BIBB; COBALT: COPP1B; |
| eCID; 1501; IllTHAHOS; LEAD; |
1 eiiGiiist; incvBT; ROXTBDZIDI: I
1 fBCSPHOBDS; BDBIDI01: SCASDIOH: I
I fHEIin.l; SIITE8; TIM; TDIGSTH: I
1 !UC: gtllTB BAZABDS: IIDOSTBI1I I
1 tl«RS; SBtllSBS; TEL10BIV1 I
1 1
1 1
1 tevlev. Profile of healthy snb-Jects. t Gnthrie, B.E.
I Baseline data for determining changes I Bobinson, B.F.
1 in intritional status froi indnstrlal I 1978
1 feed processing techniques. i Rev Zealand Sedleal
1 I Journal 87(6031:3-8
1 111 ZtrLAIt; ADULTS; FITOS; HF1I7S; I
1 I1CCD SnV
-------
 Ccgtn
 7«««-5»-»
Co
JMT 63.5*6, If 1083 C, BP 2595 C. TP 1 M Bg at 1628 C, 10 •• »g at 1870 C
                                                                                     fCOITIXDED)
nssvt



3838
long


















3839
lung

















38*0
tinq






















tXMSDII SOME


































































IIU.TTICU
8ETBOD


U



















US


















U























IDSBEB
OF CaSKS


1 2
b) 2





































a) 8
M 9
c| 11





















11*61



J < or » 5.2 «g/g (»et
t)
1 0.9-6.2 og/g (net it)

















a) Bot aiTen
bj 0.77-1.59 agyg
c| Bot giteo
A) 0.60-1.32 0.9/9
a) lot giTst
f) 0.81-1.96 aoye-
Bet it












a) 0.62-1.M ng/q
b) 0.17-1.5* «g/o;
c) 0.059-2.15 ug/g
It «




















BUB | ClBIBal IBYOBBaZICB
1
1
I
a) 2.6 * or - l.< 1 a| Balea
g/g (vet vtj I t) Feaalca
b| 3.5 » 01 - 3.6 |
ng/g (vet »t) 1 'roa a group of it autopsies.
1 fortnslc ndical exailBatioas. Japan.
j Bales, Mai age «0.6 rr. Maales.
1 ie»» aae 37.* yr-
1
| IB 1C I CISBTBTSS iOTOPSIES; JiPlt;
| limiTln; IES1IIC; CIBBIOB; COB1LT;
| CEBCIIDB; COPPIB: 11013 HEBCOBTj
I utiua; SMIESIDB: BIBSIBBSS:
I iBiiDivi; IRUOII; sctmn:
I sui«n»; TinBita; niioina; zinc:
| GC10: B10RIBI; LITER: KID1ETS;
i ClSIBfiajj CltEBBttOB; HE1ET; BOSCIES;
i EiBCBEis; spiiEi; imns; icrti:
| BITtLS; COBPU4TITE EYUOITIOBS; SEI;
| ICBE1SIC BIEICIBI
i
a) 0. 5S ng/g I a) Sorter, right upper lobe
b) Hot gi»e | b) 5 eoatrols. tlqht upper lobe
e| 0.96 uq/g j el Borkar, right loner lobe
4) lot qiven I 9) 5 coattol*. right lover lobe
e) 1.02 og/g I «l Borker. left upper lobe
f) Bat give* I f) 5 contrail, left upper lobe
let vt |
1 Jtpaiese "or*«r, 65 re old, at
1 chroaate ftodaciim plait toe 3O 71.
I Clad of aaxillarr &*& laaq cancer.
I Ctstiols, 59-18 TT oia.
I Jicii: IOIFOSE f ISSUE; aoBii: son
| SIISOW; EBIIli CUEBZL10B; ClBEtSdd;
I Hums: HTiB; LDUSS; nosciES;
| ElBCBtIS: SHI: CBBOBIOT; COPPEB;
| R1T1I.S: ZIIC: UDDSIBIIL PlIBTS;
\ imilTIOB; OCCieKKniL UtlSDS;
| ICfOIftTTOB ZXPOSOBS
1
a) 1.10 ag/g 1 a) coatrclc
b| 1.0* ng/g I t| torkec grenp I
c) 1.0* og/g | c) Borker group II
Bet vt 1
ledians I I«c«asad cef luerr and aaelter
1 vorkera, agea 55-7$ jt, expose! to
1 aaa*r aetala 1-3 decades, tile
I bcteeea cetlieaent anl death 0-1.5 rr
| in group I aid 2-19 Tt, group II.
j Controls, aa«a 13-72 ji, *io live! 50
I ka froa the tactorr. Sveden-
1
| JKtEB; C»D»TEES; KIDIITS; IITiBj
| IOISS; COBP1FITITE ETILD1TIOJS;
| IBDOSTSItl BTOIBBB; BEaSaiEBEBT
| SITBODSj inilOBT: 1SSEBIC; C1DBIOB;
| CISIOB; CKICUOl; COBlllj COl?ZI;
| CO 10; IBOB; I1BTB1BQIT; 1»D;
i iitGiitst; stacnii: sonBriiBB;
| tBCSPROBOS: BDBIOIOR: SCaBDIOH;
| SltBHUS; 5IITEB; Tit; TOBCSTEB;
| tIBC: B!IITB B1I1BDS; IIOOSTSIU
| HUTS; SIIHEBS; lEliaBIOH
1
tEIEBBBCE



Tukava, 5.
Sninki-Ia«naoto, I.
laaao, t.
Teral, B.
1980
archives of
laTlroaMBtal Health
35(1):3C-*«











.._
Byodo, K.
Suzuki, S.
Fttrwa. 1.
Beshlznka; K.
1980
Interaatloaal Irchlres
of Occupational and
EiTlronaental Health
«6:1*1-150









— ™
Braae, D.
Bordberg, 6.
Beater, P.O.
1980
Scieoce of the lota!
EiTlrona«nt 16:13-35


















(BEIT PtGC)
-------
7M8-SO-S
c«
It* 63.S«C. ST  1083 C. BP 2595 C. YP 1 M Sq at 1628 C,  10  •• 89 *t 1870 C
                                                                                       (COITIIIIED)























1
1

1
1
r
i
i
i
i
i
i
i
flSSOE EXPOSDIB BOOTS

38*1 Ingeatloa
Bilk






1
1
1
1
1
38*2 1
Bssele I




1
1
1
1 1
1 1

1
I
1
1
1
1
1 1
I i
1 1
iiiiTTicu.
BETBOD






.






la






IDBBIB
OF USES













a) a
*) e






BIICE














a) < or « 5.2 ag/g (vet
vt)
b) < or • 7.6 va/g (vet
vtj




1

1111 | SfitBll IBTOBBallOB
1
1 Serie.. profile of kealthy subjects
1 BacellM data foe deteeidnlng eaange
j la latrltional states (con lidestrla
1 feed processing teckniqaes.
1
I in itutic: UDLTS; rr«s; IIFMT.S;
| FIOGD SEIffB: BUB; KIDIETS; LITEB;
| lltK; lETIil; DIRS; FOODS; SOILS:
| TIGBT1TIOI; CIO BIDS; COPPEB;
f BlieilESF; IETA15; ZBaCE EIJHIBTS;
| ZIIC
1
1
a) 2.1 * oe - 2.3 I a) Hales
ag/g (vet vt) 1 t) fesalas
b) Z.O * oe - 2,« )
ig/g (vet vt) t (cos a groaF of Ct aatopsles.
| feceasle aadlcal ezaalnatloas, Japan.
1 Bales, neao age *o.t re. resales.
1 sean age 37. » rr.
1
| IBICt ELEiEITS; aVTOPSIES; JaPlI:
1 IICBIIOT; 1BSCTIC; CUBTOB: COBU.I:
I | CBBCBTBBs CCFPBB: I BOB; BB1CDFI;
| | IIDIB1J aiSBISIOB; BaieilZSE;
1 | IBCmotl; 1IIII01T; SC1BDIOB;
1 i seiBBTOS; uiaiTOB: niiDioB: ziic;
1 i i eciD: BIOBIII: IITEI; rums:
1 1 | CMIBSOT; CEflBElLUS; BB*Ht; HOSCIES;
1 1 1 MICJ11S; SPIFBI; tUISS; 10IT1;
I 1 1 BmtS; COBPIB1TITE STILOITIOIS; SH;
4 | | FC3HSIC BICICIII
1 11
f II
1 38«3 | I US 11 lot glreo I 0.50 ng/g vet vt I
1 flu
1
1
1
1
1
1







38««
lall




















sole | |
1 1
1 1
1 1
1 1































1
1



































II 1 1
|J | | Japanese vorker. 65 rr old, at
II 1 1 ckroaate pcooiclag plait far 30 re.
|| | I tied cf saxlllarj asd lung caacer.
II 1 1
1 1








1


























































I J1FJB: 1PIPOSE TISSUE: 10BTI: BOIE
| B1BIOI; (Sail; CIBEBniVB; CEEBBSOBi
I SIOBETS; tITEB: IOIS5; BQSCIIS;
I E1ICIII5; Slllt CB80BTOB; COFPIB;
| BrillS; ZIIC; XIBISTBIal PI11TS;
| 1IBII1TIOI; CCCnPlTIOIal BaZUDS;
i toremioi IIPOSDBE
1
1
1 1 revlev at vorld literatare ox the
f accoselatton and bloeeoeeatratloa of
1 selected tezlc trace eetals la kaaan
1 late aai aails and other aaaaali&a
1 halt, fie. Balls, elavs and hoofs.
1 Iitulated by geographic area«
t gcadleat. aaalrses In pps, and
1 aitborlly feea ever 100 references.
1
| Illicit 10STBU.II; C1I1D1; CF.ITNL
| lEllICI; IOt«E; BICCll BIST: in
I miiio: soon uraici; SOOTKEIST
| ISII; OiniD KHSDOB; U»ITtD STITES;
| Bill; IU1S; 1EVI3B; 1RIMIT:
I nsiiic; BOici; ctDBm: cBtcHin«:
\ CCS 111-, CCKll.; UkD; 5SBC11ST;
I iiCKEi: sninoB: TI«: IIBIDIOH; in
I CCUOIIOI; Itlaftl ffOPQLatlOIS;
I lUiccuniKioi; iioiiBiciiiou; LUD
1 icturrioB-. PCPVLITIO* ETPOSOBE-. IITSC
i tciintoB: TIUCI simns; BEXILS
i
•IFESEICE

Gotkrle. B.E.
Sobiason, B.F.
1»7*
lev Zealand Helical
Journal 87(6031:3-8








Tokava. a.
Snzaxi-Tacniaoto, !l.
iaano, n.
Teral, B.
1980
lechlres of
Fnrironnantal Be alt b
35(1):36-4»













eroto, E. |
saitttl, s. |
Fnrora, 1. |
aesaizaka, 1C.
1980
International Irchires
of Occopatlooal and
IDTlconnental Health
4(:iai'-iso






Jenklas, O.I.
1979
BPl-600/»-79-0«9, 18«
PP.




















































                                                                                                                                                                                             o
                                                                                                                                                                                             NJ
-------
Ccpp«r
7MO-SO-«
Co
Itt 63.5««. (F 1013 C, W 2595 C, TV  I u B* at 162« C, 10 (a  B?  «t  MTO C
                                                                                         (COVT1TID*9D)
nssn

38«
lall













3*a«
Faacreaa

















3817
Fa«ct«a*













3048
Faaryax














IPOSBBJ toBiz

atLoa
































































1H1TTIC1I
BETIOV
US














u


















us






























mm
OF C1SXS
> 15
17
19
1 «











a) 5
M 2

















a) 1
b) 5













a) 1















I1KE

) lot jlY«n
I lot 9iT««
1 lot give*
1 lot giT«n











a) 1.4-1.9 ng/g (wet wt|
*) < or « 2.0 ag/g (wet
•tj
















a) lot gl»«»
b! 0.46-2.2? ag/g ««t «t













a) lot glT«a
t) 0.90-1. 16 «g/g ««t at













Bill

1 15.6 t or - 1.8
g/g
) 21.9 » at - 27.9
0/9
O 23. » * oi - 12.9
<»/g
1 10.4 * oc - 0.5
9/9







a) 1.7 * or - 0.2
09/9 C«t »t)
b) 1.0 » or - 1-»
B9/9 <"«t wt)















i) 0.39 ag/g not wt
b) lot glvea













a) 0.80 ag/g not wt
b) lot gin*













t
CM mi moisiTioi

t) lei, low 11004 prastare
b) Bea. high bloct pxesrare
c) loan, low blooi pressace
{) loata, high blood praasare
S«b1«eta Ml«ct«a bT blood prasaura
tank fcoa a trarioa* st«di-
fatlaated daily latako. 1.5 19.
FolrMSlaa culftaats of Tokclaa
Iflaidi, erotted condltiona.
ntalstamcc aconoar- Son, Ma* «g«
4! it, aaai It 1*7 ci, Man »t 7» kg.
Bcna, Mai ago tS rr, aoan It 1«S
ea, aaaa «t n kg.
tepPH; me; Bioon SSBOB; BUI;
nils: quit; in nuui
a) Bates
1) F«al«s

ftoi a groat of «1 aatoo(l«s.
forniic acOlcal ozailaatloa*, Japaa.
B*l«a, Man ag« »0. 6 jr. r«aal«a.
a«aa ago 37.4 jr.

met ziMcns; inopsits: j»pn:
itoiiigi; aisEBic; ciDBina: COBU.T:
cnciini: cctPiB; IMIJ SEBCHBI:
tlCtOC BieiKlOB; UI6UMS:
BttlDiuri; iiiinoir; SCIIDIDB:
stiTiivi; iiiuiint: miDioB: znc;
eclt; BSOBTIl; tniB; IIDIIIS;
Clllim: CIBEBE1LOBJ BEIBT; RDSCIBS:
IllCtllSt SIIEII; tllSS; 10BTI;
BtTUS; COIIaUTITB STliOllIOIS: S!I;
FCBIISIC BEIJCIBE
al lorkar
b) Coatrols

japana* worker. 65 rr old, at
chxosat* fiooaclaa plant for 30 TC*
rial of aaxillarr aa4 lang cuear.
ccatrot*. 59-78 rr oW.

Jim: IOIPOSE nssuEi toiti: sou
mm; Hiii: cmaniw; cnsspon;
(Ifiins; llttK; LOISS; MSCUS;
fiicms; ssii; cstoaoH; COEPSH;
cmiSi tile; inastiiu HMT$;
iiitutioi; cccnusnii «i»»s;
cctaimci ZIFOSOBB
a) lorkar
b) Coatrola

Jacaaew werkar, 85 rr oil, at
caxoaate prolaelng plant tat 30 TC.
Cl<9 of aailllUT and lung ca«c«r.
Ceitrols. 5S-TS rr old.

J1FII: 1DIPOSB TTSSOIJ 1OBT1; BCIE
Mtioi: BBIIB; CIBEBIILOIIJ CIBEBRUB:
IIDIHS; UTEB; IOIS5; BOSCltS;
UaCEfIS; SIM; CBROnuH: CCEPH;
HIIIS; IIIC; IIDOSnilt FI1ITS!
llltUTIOl; CCCOPIIIOHII. B1Z1BDS;
fOfDIITIOl IIFOSVIB

BHEJMCI

ncKoaiie, J.a.
eothrlo, B.I.
ftiot, I.l.S.
197*
lavrican Joans 1 of
Cllalcal IntrltioB
31:422-428








Tnkawa, S.
Sankl-Taoacoto. B.
aaaao, x.
Taul, I.
1980
archives of
Eftvlxorattatal Health
35(1>:3«-44











ITOjO, K.
Sazakl, S.
TttTUJB.* !•
Beshixvka. S.
1980
International archive*
of Oceapatlooal aad
EavlroBmaatal Health
*«t1«1-150






Hroio i
Suzuki, S.
I«r«ra, I.
Reshixuka, C.
1980
iBtenatloaal IrehiTes
of Oceapational a&d
r«Tlrota«atal Health
46:141-150







(IIIT FISB) 	
-------
ccpper
7440-SO-8
CD
lt» 63.546. IP  1083  C,  B* 2595 C. TP
                                       1  m» Eg at IC2« C.  10  ••  H<7 at 1870 C
                                                                                         (COfTXItTED)
IISSDE txzosnn Boort AIAITTICAI i amsxt IAIGE i »g»i i GEIIKU HEOBBATIOS



3849
stin










i

1
r

3850 I
Spinal 1

1
[
1

1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
f 1
1 1
J 3851 |
1 Spleen I
1 1
1 1
1
1
1
1



1
|
1







3852
OriM




























IITEOD | OP CASES I (
I If
1 1
IAS a) t a) lot giTen I a) 0.38 ag/s vet vt I a) torlter
b) 5 b) 0.29-0.45 ng/g »et at 1 b) lot given I tt controls
1 1
1 I Japanese aocler, 65 vr old, at
1 1 cbzonate rrcdaciag plant foe 30 yr
1 f 1 Bled cf aazillarr and long cancer.
1 1 Controls. 55-7* yr old.








t

t I-rar opectros 1 a) 7
1 1 VI 12
1 1
|
1
1
1
1


t
1
1
1
1
I
1 1
1 »A 1 a) 5
1 1 W 3
t 1
1 1
1
1
1
1
1
1
1
1
1
1
1
1





Coloriaetrr



























4










1 1
1 | JJf»«: ADIJOSE T1SSOE; AOBTli BOIE
I | MItOf; BR1I1; CBtlSBlIDB; CEIIEXD
1 i mains: iiTEE; trass: mrsciES;
1 1 IIICBEAS; S*M: CBBOBICPS: CCPP'fl;
1 | HTALS; II 1C: IIBOSTSIAl M.AWTS;
1 1 IfBltATIOl; OCCUPATIO9AI HAI1BOS;
i i icpoimo tnosniE
1 1
1 1
a) 35.3-182.9 ag/g; I a> 89.0 * or - 57.6 I a! flotor teuton disease patients
b) 19;7-11S;i «g/g I ag/g I t) Controls
Brr «t I b) 06. J + or - 23.8 I lentral horn ttssm, antopsv
1 ng/9 |
1 B*T »t 1 latients tlef of svotropnic lateral
1 1 sclerosis and progressive nvsculae
1 1 atrophy, Kan a««. Si. 6 » or - 13.1
1 1 it. Controls died at various
1 1 diseases at <0.9 » or - 11.1 jr.
t 1
t l itEis: »onis; Anopsus:
i i •lOBoaoscniii DISEASES; SPIVAI ODII,-
1 1 tlOACCWglATIOI; CllCIOS; CCtPBB:
1 { IfCI; IHC; BtSEAXESZ; BIHlSj
l i smnoR; ZIK
f 1
1 1
< or » S.t ag/g (*et I a) 2.2 + or - 2.1 I a| (ales
t) | «g/g (wet vt) | 1) feaales
< or > 3.8 ag/g [vet I b) 1.3 « or - 2.2 I
) 1 ag/g («et "tl I Hot a groap of Cl autopsies.
1 1 forensic sedieal ezaiinatioo*. Japan.
1 1 Bales, nean age «0.« Tr. Fewtles,
1 1 s«aa age 37.4 fr.
1 1
1 1 IIACE EtERmS; AOT07SIES; JAPAI;
1 1 AZ8BXIOI; IBSIItC; CtDBIOB; COB1LT;
1 i CEDOEta*: CCPPEB: IBOS.- UJBCBBT;
1 i mm: IAGIISI«C lAifiAEisx;
1 1 PUSIDIDS; AHIROBT; SCAIDI08;
l i ftiEiivR: inaiura; VAIASIM; znc:
( l ecu; BRomi; tiTEl: Hours:
l i ctBZBtm: cttEBEimi: BEA»: ROSCIES;
1 | FIICBIIS; SPICTI; LVKS; 10B1A;
1 1 IIETA1S; CO(IP«BATI»S CTAU7ATIOS: S!I:
1 | rCMISlC HECICIIE
1 1
1 1
>} 22.8-7&.J ag/24 ar 1 a) 52.4 «g/2* fee 1 a) Initial levels
i) 38.6-130.6 ag/2* kr I b) 89.7 ag/24 ar 1 t) Dorina 5 f leecine aallv
:) 35.4-103.2 ag/24 hr t c! ''2.1 «s/2« hr 1 el S iars after leaclne vithSraral
1 1
t 1 B«altkr volnnteers.
1 1
1 1 CCIIEI: 1ETALS; limit 1E1AWI.ISH;
l l tistASfS; mil: BICOD SIIOB; oint;
1 1 SK» CISEAStS; ABIIO ICIDS; Ball;
1 1 CCSPAIITITI tfAlOATIOIS
1 1
(MET PIG I)
I BERBEICE
1
1
I
I Bvodo, E.
1 SanU. 5.
1 Tarara, E.
1 Beshizoka, K.
| 1980
1 International Archives
1 of occupational and
1 Envlrannental Bealtb

': 1
i
i

i
i

i
1 Knrlaader, 1.8.
1 ratten. B.I.
1 1979
1 Annals of Veorologv

1
1
I
1
1

1
1
1
1
1
1
1 Tnknva, 8.
1 Sazaxl-Tasnsoto, 9.
1 Asano, It.
t Terai, I.
I 19BO
1 Archives of
1 Environsental fiealti
1 35 J1): 36-44
1

1

I
1

1

1
1
1
I
1 Kriabnaaachari,
1 K.A.V.B.
1 197*
1 Aserlcaa Journal of
t Clinical Intrition
1 27:108-111
1
1
1
1
I

-------
7«»0-50-8
Itf 63.5*6, HP 1083 C. EP 25-95 C, TP  1 « Eg at  1«28 C,  10 as Bg at 1870 C
                                                                                      (CO«TI*0!D)
TISSUE
3* S3
Orine














ETPOSORE BOTCE
lageStiOn















1MLTTIC1I
MtBOt
US















1 OH BIB
OF C1SSS
al IS
bl 17
C| 19
3} 15












B1IGS
a) lot given
b) lot given
C) lot given
d) lot given












nil
a) «3 + or - 51 ug/2»
to
b) 3« « or - 22 ng/24
ht
c) 31 * or - 29 og/2*
hr
4] 25 * or - 8 ag/2«
hr








CII1B1L IITOB«4TICI
al Be«, Ion tlood pressure
t) gen, high bloed pressure
ct Boiaa, law blood pressure
dl voiav, high blood pressure
Slblects selected by blood pressure
rank froi a prerioas stady.
istiiatea dallT iitake. 1.5 ag.

EolTneslai ccsLdanta of Tokelav
Islands! croioed coDditioae,
Eitsist«ce econo»T. Ren, seal age
»i TC. aaa« ht 167 cm, aean «t 7» kg.
«o««n, icaa age *< yr, aeaa tt 16S
c«, *eaa tt 79 kg.
CCfPEB; 11K-. BLOOD SEBBB; B1IH;
I1ILS; mill; III liiLin
EIJEBEICE
BcKenzie> J. a.
Guthrie, B.E.
Prior. I.I. I.
1978
aaeclcan Journal o£
clinical latritioa
31:«22-*2»









 Ccvaarla  (9  CD
                          CI)
 *1-««-5
 C4-B«-02
 » 1*6.1, HE 70 C. B? 291.0 C, It 1 na 89 at 106.0 C
iissat
3««
Breatl












zitosors sornt














itUTUCU.
8ETHCD
8C-BS













lOBBIE
OF CISIS
?a (387
sanples)












EilCE
lot given













asii
1.0 ag/1
Geoaetric












etltitl tllOBHlTlQl
teacacei at 25 C and 760 nn Bg
63.1^ occurrence
Ic>er aad upper ooe-Sigaa Units 0.2«
aad ».2 iq/1

KalthT, U-35 TC old, nonsaelciiig.
or tan blacks and Caucasians.
Cnlcago, II. tlgidlT-contcolled
ciperiaeatal coidltions.
HI1TI; tICCBOLS: IltllOIS; IDBLT5;
CEtOBKlTIO ETOBOCMBOIS; TOIiTILE
cieinc cosEcmtDS; BEILTH BIUBDS;
IIR1I1TICI; SETltOLISI; HET1EOLITBS f
FCPClltlOI ETPOSOIE; HBB1I ISSiS
EETIEEICE |
Krotosrynski, B.K.
Sraneaii, 5.H.
C'Heill, H.J.
1*79
Journal of Inalrtlcal
Toilcoloqy 3:225-23*








  Ctesol (8 CI)  (»«»
  Ibenol, aethjl-  (9 CI)
  1319-77-3
  C1-B8-0
  BI 106.10. »P 10.9-35.5 C,  BF  191-203 C,
                                            W  1  an Bg at 38-53 C
TISSUE
3855
DCi DC









HtOSOBE BOOTS
Deraal










ItllllTICtL
flETHOD
9C










• OHBI9
OF C1S3S
a) 15
b) 10









B1IGE
a) 8.8-128.5 ag/g
creatisiDe
b) 31.7-**. 8 ng/g
creatiniae







9Z»
.
a) lot given
b) lot given









cziiau. iiFoaauici
a) Controls
t) (orkecs eiposad to chlocaphenols

forkera in barbicide nanaf actariiig
plants.

6I8BICIOES; HOB STB III P11ITS;
CCCSPtTIOIal B1I»EDS: PESTICIDES:
FCEOLtTIOW IiraSOBE: HMSOBEKin
MTIODS; CB1CBIIS OESIIIC COHP00KD3;
FE'IOIS; C»HD»; OBI1Z
EZrZBSICZ
Tan Boosialen, P. 3.
Klein, t.l.
Oranaond, I.
1980
International archives
of occupational and
Environmental Health
*5:57-6Z



-------
    C»«M  (8 CI)
    Eenxene,  (1-nethylethyl)-  (9 CI)
    58-82-8
    c«-Bi2
    •I 120.15. » -96 C. BP 152  C.  TP  10 »  Hg at  38.3 C
IISSIE



38S«
Breath










3 §57
Breath I
1
1
1
|
|







Eiposms BOOTS















1
1
I












AIA1TTICAL
BETBOD


SC/SS











GC-BS













I ITJSBBS
I OF CASES
1
1
8











54 (387
saiples)












11KI



lot detected-21.0 ng/hr











I lot given
t
1
1










8»l



2.6 ug/hr











0.3 It ng/1
SeoMtclc












eiBiBAi. MFOSBATICI



Ccipond related to norul
xetabolisi. lo other details given.
Cryogenic caipling technique.

Beilthy eilitarr and civilian
eeployees, 0.$. Air Force School of
lerospace fledicine, ages 23-»7 yr. 3
iiokera.
Efizms; CBIOBIUTEC STDBOCIEBOJS;
CflCBIlE CBG1IIC COIPOWOS:
csioBOBHiznis; FiocBin COIPOHIDS:
fttits; ilcceotS: fins; 1DOITS
«ca
-------
CFClotuaM
CC-112
II t«.1S, IF 6.5 C.  8P  SO. 7 C,  W 100  H  Bg at «0.8 C
1155*1

3B59
Bianh












nrlaa







nfOSOBS BOOT!















Bactal







iiumcit
KEf BOD
SC-BS













9C/B5







IBB BBS
or cisxs
5« (3S7
SMplM)




















IltEE

lot 4i**i













"''" "* 1Vl







BUI

5.0 as/1
fieoattcic




















GEIIUL IIFO1BUIOI

fcamcca at 25 C »a 7SO a* Bg
(>.«t occirrtne*
lover aid afpar oae-Sigaa limit* 2.7
" "
BaalthT* IB— 35 fr old* BO&saolclngr
attaa black* aad caacaxiaas*
Chicago. It. KigiilT caatroll«9
axpaciMBttl coiditioaa^
IBUTB: llCOBOtS; IIUWIS; H>HMS;
CILOBmTED STDBOOBBOIS: TOtlTILB
OMUIC CClICinDS; HU1TB BHIBIS;
iiBiUTioi; amioiisri: BiTteoims;
tcroimoi iirostriB: IIBII tuts

Ifl cfclohoaaol (aataboUta}
Data also on solm.t* IB factocy air

Icckara IB shoe teetorf IB Italy

tBIBB; BTD10CU1OB3: BJRUO1IXES;
lt»lT; HDoniJll ITIOSFBIBtS;
imsmii neiEii: IIB potmriai-.
ccciruioni Di«isis
IIFEUVCE

l-wtenrMkl. t.t.
SmnBio, «.B.
O'leill, B.J.
Join*! of InalTticil
ToiicologT 3:225-23*









BrugsoB** F.
FaTaB* I.
1980
Toilcologr and applied
Ptarneol04T 53:220-224



              MtftTl~
  10B-87-2
  C1-BU
  tl *g.10, » -116.» C, BV 100,3 C. TT «» » Eq at 22.0 C
II3S«
Inath


EMOSVBB iOOTI




8IVBS


lire Bat
OF cuts
*


III6B
lot 4*t*ct«d-13«0 ag/ht


Bill
1.6 ««/hr


SCIEUL mOBMTIOl f
CeipoMd fcoi aafcaoia orlgia. lo
cthat latailt gitaa
B«aUhT allltarr a>9 civlliaB
«lplOTM>> 0.5. llr IOCC* School Of
laroapaca Ratlcia*. ages 23-*7 ji. 3
not«n.
minis; cBiosiBiTSD naaacaBBOist
CBIOBIKS oiemc COIPOOIOS:
CBtOBOBEIIlKSt FITOSIlt COBPOUIDS;
IBZITB: HCCBOlSj THIS; 1BC1TS
BETESBICE
-
COBkl«. J.P.
Caap. D.J.
»*lch. B.I.
znvlronwattl Health
30 t2(: 250-295
i
-------
crelohaiase, 1,2.3,a,J.«-»axac!>loco-. alpha-  (6  CIJ
'--'"---ane, 1,2.3,»,S,«-ka)zachlaro-,  (1alpha,2alpha.3beta.«alpha.5beta.6b«ta)- (9
   MO.S3, 8J 1S9.S-UO C, BT 289 C, »P 0.02 u Ba, »t  20 C























fISSVS



J««2
Blood.
MtU









IUOSOBB soon




















1
1
1 1
1 I
1 3t«3 1
1 Hood, |
1 >kole I
1 1
1
1





1
1
1
f
1




,
1
1
1
1
1
*
39t»
Bilk





























lumicti.
HBfBGD


BC



















BVBBBB i um RUI i snmi aronutoi i unmet
OF CIStS 1 1 t
1 1 1
1 1 1
•I » of 19 I a) 1.*-B.3 •o/l a| 2. S af/1 1 *) 6e*eral population - Continental t Kraathacker. 3.
b) 8 o* •« I b| 0.7-2.5 aoyi b) 1.3 ag/1 1 *o«th (»rban) 1 lleble-RoUuh, T.
O 1 of SO 1 c) 3.4-29 ooyl c> 9.2 go/1 1 b) eeieral population - island I Ktal-), C.
dj 28 of 14) 9.2-157 ««/!
28 |
f
1
1
|
1
1
1
1
1
<
|
1
1
1
1
1
I SO-BC a| t« | •) lot detect*!
1 b) 2 I b) lot applicable
1 1
1
1
|
1
d) 38 ag/1 | (ratal) I TkaleeTic, B.
Geometric Mans I c) Sipoaod workers - Continental 1 Miner. I.
1 iccth (drban) I 1910
1 d) Xxposed vcckan - Continental t latamatioaal archive
1 sootb (arban) 1 of Occupational and
1 1 EntironaentU Malta
1 Oeneral ponalatlaa. a?<* «-79 rr. 1 «5: 2 17-220
1 occipatlocallr exposed >ock«n. »g»f 1
1 2C-62 ?r. IiaoslaTla. (
1 1
I ivaostmi: MOOD saas: DBB; BOB; i
1 EM; CBLOSlliTED HTOBOC»EBO»S: |
I cnotitz oteuic COIPOUSDS; (
i iKicnorocicioBmu; PISTICIDBS; i
l occopiTioiii nzuos; PESTICIDS i
1 1ISIB1HS; P05011TIOI RPOSOSI; BHB11 I
1 IttlSs VtStt UtttS I
1 1
1 1
a) lot detected I a) love Canal residents | Bristol, o.v.
b) 0. 1 09/7 | b) Tolnteec*. 1 positlre 1 19SO
1 man of polltiTe sasples. Ll»lt of I IP1-600/1-80-03S, «0
1 •eaaiireBeikt. 0.0a7 H4/9 I pp.
1 Cloself watched, sisiltaneons control I
1 sanplei vere got proiided for I
1 analysis aloaq «ltk tkose fro* the 36 1
1 1 1 lore Cull area residents saaplcd. I
1 1 1 lacking Maninofal control at 1
1 I 1 literature data relatin to the I
1 1 1 significance of the Ion residues I

(
1
f
1

1
1
1
|
1
1




CO- 1C
GC/BS


























i











1 1 found la the field «»pl» analyzed. I
1 I 10 definite coacllalon* can be drava 1
< I fzoi ti« results repotted, |













< 0.1 o»/*9











1 1
f fesideats of re* Tor It. Controls, I
1 caplorees of the Snrtroueital I
1 Protection tamer »n4 aniTarstty I
1 «t«de«ts, forth Carolina. |
1 1
1 III T01K; WOKH CIROIUI; B1OOD; |
1 9MSWMJIT HrrBOJSj C9LOBITC OIXStBIC I
I ccatoonDS; ctia&otztssKS: \
1 iixicRioicBtnziz: POIICBIOBIITITEI) i
l ntitmss poptrHTios SIPOSUSI I
i i
l i
Wot applleafele I lactatlif lothcn 1 Kodric-Salt. S.
1 < Salt, t.
I 17-«1 TT old* froa $lanaia Province, 1 Clie, K.
1 TvgoslaTla. 1 1980
1 1 Pesticides 1ooltorin
-------
CfelokuaM, 1,2.3,«,S.6-li«iackloro-,  beta- (» CIJ
Crdektxu*. 1,2,J,*.S,6-t«nckloro-,  (1alpaa,2beta,3alpfca,*Jbet«,5ali>ka,6beta)-  (9
3M-8S-7
Cf-B6-C16
If 290.83, M 31*-31S C fsabliaes), BP CO C at  0.58 n Bg,  TP 0.005 » Eg it 20 C
TISSUE



3665
IdiBoaa























36 6€
Ulpose










3M7
lolpose










IPOSOH BOOTS




















































uumcu
BBTBOD



























ec























iD9Bm
or cists



























60











a) 27
») 1
C) 1









UK*




























0.23-9.79 ppa











a) lot firea
B) Bot ei»ea
c) lot alien









nn t GEimi lifotBino*
i
i _..._.... . _ .
i
1 l«le«
1
I liposed persons IB tke United States,
I tke letkailnndB, sseden, Israel.
1 Japan, VSSB, Poland* Gernanf* India,
1 Balgarla. Pakistan, lastria.
1
I elevated seTae cholesterol, abnornal
1 Its*, or iapalraeat of Bearcaascolar
1 faietlOB a(t«r acvte ezpo*ata to
I cciSi.Mti.OBi of pesticides, tat »ost
1 data sho« no adTerse effect* alter
1 lca«-tecB occupational exposure.
1 1DS1BT1; B'JISISU; GJBS1II: noil;
| IS&m; 31?l»; ISTHEB1MDS: IUI5TM:
1 tciiBD; iissu: svcDii; UIITID
| STlttS; IBIPOSE TISSOE; BlOOIi BLOOD
| tllSBl; »IOCI StMl; E3TTBBOCTTBS;
| HOSOCITES; BILK; UBISB; BET1ES-.
I I»HH HUlBtS: OCCD?»TIO«U BKUOS;
| K>*nmO« IIMSOK: ISOPtlSBS;
I (ISTICIDIS; CBlOtllB OBSalTC
I CCHOV1DS
1 .
I
0.7« pps 1 laripkeral kidnei fat, roatine
1 patkoloqlcal eianinatlons
1
1 iqes « ao-ej jr, Belaivs
I
I fllSIO!!; kOTOPSIBS; >9IK)SB 1I3SOE;
I SIOICCtHHI»TIO»; PESTICIDES; DDO;
1 cm: on: BIILDBI*: ISPTICIIOB
| tfOTIH; SEllCBlOBOBEltraB; mguS:
1 cnoitis oBeinc conaams
i
I
a) 1S.7 » or - 19.78 I a) tospital patients
ppa |k) 13 TT old Caaale «itk Tasko
b) 0.*7 ppe, fat |c) as yr old aale wltfe chronic PCB
basis 1 foiaoAlnq
c) 2.0 ppa, fat basis 1
1 Japaa
1
1 IClYCIItOBmtlD BIPBEITLS: 1ST;
1 BillCBLOtOCYCLOBItllE; BLOOD fHSB»;
I SYSTER; pzsuciois: utross nssns;
1 IIVR; KID1IITS: OBMIU9
1
lirEEEICE



eicaaannv H.B*
BacOonali, I.E.
»77
Icatozieoleor »d
EaTirOBBeatal Safetf
: 89-1 10



















De-taBekaeere. I.
Stearbant, f.
Terstraeten, B.
Kips, S.H.
1978
loileoloolcal Earopean
leseareh 2(2) « 93-98





Isone. 1.
Ibe, S.
Takasatsv* H.
aoki, >.
Rikl. S.
Palirara, K.
197S
Tvkaoka Heiieal Journal
6* {10: 6 10-6 16



(Hit USB)
-------
CTCloaexane, 1,2,3, *.5,6-hexechl0ro-, beta-  (•  CI)
Sigijs""*' '•2*3'*«s'*~h"»e*loro-,  (1alpha,2beta.3alph»,abeu.5ali*a,6beta)- (9 CI)

C«-IC-C16
II 290.83, R( 31V-J15 c  (sgbliaes), BP CO C at  0.56  u  Bg,  TP 0.005  as Bg at 20 C
                                                                                      (COfTIPOlD)
HSSffl

38«8
Blood










|
|
1
1
|
1
1
1
1
1
1 1
1
1


38 «9
Blood,
plasna




|
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 3870 I
1 BlflOl, i
1 (kola 1
1 1
1













































mosaic BOOM

















1UITTIC1I | suites 1 B1IGX
RETROD i or cisss i
1 1
J 1
t 1
1 1
1 1
1 1
1 1
1 f
1 1
1 1
1 1
1 1
1 1
1 1
1 1
i 1
1 1
l 1 1
1 l 1
1 1 1
l l l
i J
1 1
BUI i ert BUI nroiMTioi
J
1 >
1
1 Izposet pezscas ia the onlted States
1 tka setherlaids, Svedon, Israel.
I Japan, USSR, Poland, Gersanv. India,
1 Eilgarla, Pakistan, instrla.
1
1 Reported cases of hypertension.
I elevated serm cholesterol, abnornal
t IFSs, or iapalraent ot aearoanscalar
1 function after aente exposnre to
1 eoatinatioas of pesticides, bat sast
1 data shov no adverse effects after
1 long-tern occapatlaial exponre.
1
1 lostsiit BoieiBia: era^nt; KDU:
| ISmSl; J1P1I; IETRESI.UDS: PIKIST1
i JOHID: EOJSJ*: SVIDEI; OBITED
t STITBS; jiDIPOSI TISSUS: B100D; BLOO
| FI1SU; BIOOD SEBUB: SSTTBBOCrlES;
| XfOITOCTTSS; Et£K; VBIVl; BEfTZV;
1 HtllTB 3IZIBCS; OCCVP1TIORU R1Z1BPS
| | | IC7DUTIOI UPOS01B; IIOPIISRS:
( | t I15TJC1DIS: CB10BIIE OBG11IC
1 | I CCIPOBUDS
tit 1
til 1
1 a) 2« la) lot given a) 1«.« » or - 1O.45 | a) Hospital patients
1 b) 16 | b) lot given ppb I t) Enacitted persons
1 O 37 J c) lot givea b) 25.5 t or - 22.01 I c) loa-eaaciated persons
t d| 1 It) lot given ppb I d) 13 rr old f«nale vith Tasbo
1 •) 1 I e) lot given O 14.3 » or - 11.00 I e] 2> rr old nale «lth tplastic
J 1 P"P.b f •••etift And stonicich Cttnc*Bi?
II d) 19 ppb I
1 e) *30 ppb | Japan
1 1 1
1 1 1 I01TCB101IIITH> BIPBEITIS; BDT;
1 1 1 BCI1CBXOBOCYCI0RR1I3; BIO08 PlaSBl;
1 I i iropusus; Jipi>; atsnoinssnm.
1 t I SISTER; P-STICTDIS; JDIPOSE TISSUE;
J
1
1
SC-EC

















































a) 3» |a) 0.2-O.C sg/g
VI 11 | b) 0.2-1 ng/g
I
























1 ZIVBR; BTXDIEYS: OREITUR
1
1
a) 0.3 ng/g | a) love Canal residents, 50* (17)
b) 0. S ng/g I rceitire candles
1 tl Tolonteers, 551 (6) positive
1 Maples
1 Bange and teas of positive sasples.
1 licit of aeasnresent, 0.21 no/g
r Closelr natcbsd, sinnltaneoas control
f sasples vere not provided for
1 analvsis along vith those from the 36
I love Canal ares residents aaipled.
1 lacking neaninvfnl control or
1 litcratare data relative to tie
1 significance of the lo« residees
I fensd in the field sanpl«s analyzed.
1 nc definite conclusions can be drain
1 fios the results reported.
1
1 Residents of lev lork. Controls,
j etplofees of tke Invironnental
I Protection Igencr and inivecBitj
I etedents, forth Carolina.
1
| 111 TOM; HCFTH CtEOUti; BLOOD;
| RllStnEHEIT JITBOBS; CHLOBTIE OKU1C
| CCBKHHDS; CH08OB*IXSII$:
1 «!i»cstoacsiHB»i: POITCEHOBIW ITIB
i
BtmnrcB

Deichaann, J.B.
lacDosald. I.E.
.1977
Ecotozicologr and
Environaeatal Safety
1S89-110





















Inoae, r.
Ibe, S.
Takasatsa, R.
loki, 1.
Blki, S.
W75
Fakaaka ledlcal Journal
66(10:610-616







ristol, D.I.
980
Pl-600/1-80-036, 40
P.























                                                                                 (lilt IIGB)
-------
t,2,3,a,S,«-texackloro-, beta-  f« CI)
t,2.J,a.5.S-k*Mckloro-. (1»lpka,2beta,3«lpka,,«bet«,5alpka.6b«ta) - (9 CI)
 CFdoaezaae,
Crclohezane,
319-8S-7
CC-BC-C1C
•I 290.83. IP 314-315 C (siblisea). BP 60 C at 0.58 u  H«
                                              TP 0.005 » tg at 20 C
                                                                         (C01IIIUED)
lissni
3871
I idler
3872
lint
1
|
3873 1
lilt
387*
Bilk, fat
3875
Oceatss
xiposTOK BOOM

I
1
1



1I1LRICU
nraoo

1
1
i
GC-EC
oc/ss
GC-BC

man
OP C1SIS
1
1
10

») 1
b) 1
Inez
t applicable
ot applicable
a. 1-18.6 o«/kg
a) lot film
b) lot given
c)  or - 1.51 I after iell»«rT- 5esidents of Osaka 1 of Occapatiooal and
ppa 1 Prefecture, Japan, »aried fllets and I ZnTiroaseatal Health
f) 2.07 « or - 1.00 | (nviroBaental conditions. | 43: t-15
PPa 1 |
1 oiPH: iDoiTS; itctiTioi: niK: I
I BIOCCTBOIITIOB; PE3TIC1DIS; OB5HIC |
I CEIOSin COBtOOlDS; POLTCmOBIUTE!) 1
| EI»B?ITLS |
• 1
1 1
a) 23 ppa (fat basis) | a) 73 YT old i*l« vltk coloa caacer I Inoae, T.
b) «.1 ppa (fat | c) 66 rr old aale with stonach cancer | ibe, s.
basis) | | Takaaatsa. (1.
1 Japan | loki, ».
1 | niki, 5.
1 I01YCELOBIIITID BIPBZ1ILS: DDT; | Tnjinara, 1C.
1 EfTtClIOBOCTCIOBITilt; BLOOD PLISBl: 1 1975
I IZ07LISJS: J1P1I; GlSTBOIlTESnilL I Tuknoka aedical Jonraal
1 SIStEl; PtSlICIDBS; 1DIPOSZ USSUX; I 66(10:610-616
1 I1TZB; KI01ETS; OSIITIB 1
• 1
-------
    Cyclohezane.  1.2.3,«,S.6-bexachloro-.  delta-  (8  CI)
    Cjclohezane,  1.2.3.*.S.6-hezacfcloro-,  {1alpha,2alpha.3alpha,*beta,5alpha,6teta)-  (9 CI)
    31$*86~fl
    ce-B6-ci«
    H» 290.83, ft 141.5-1*2.0 C, BP 60 C at 0.3* mm  Eg. vp 0.02 mm Bg at 20 C
IISSOI

3876
Blood.
• bole






1
1
1
1
1
1
1 1
1
1







EIPOSOIE BODTE 1ULYTIC1L
BETBOD

GC-BC



J
1
1
1






|
|
1








1 Bragg*
1 OF CASES
i

a) 33
b) 12























*"se

a) 0.1-0.2 ng/g
b) lot applicable























•Elf | GIIIB1L IIF01B1TIOI
1
1
a) 0.2 ng/g I a) Love Canal residents. 9* (3)
b) 0.5 ng/g 1 positive
1 b) Volunteers. «« (j) positive
I Bange and Man of positive sanples.
1 Ilsit of aea sure neat. 0.12 ng/g
1 closely natched. sinnltaneons control
1 sanples vere not provided for
I analysis along vita those fron the 36
j tove canal area residents sanpled.
I Lacking neaningfal control or
1 literature data relative to the
1 significance of the lov residues
1 found in the field sanples analyzed.
1 no definite conclusions can be dravo
I fron the results reported.
1
1 Besldents of Ren Tork. controls.
| eaplovees of the SBVlronsental
I Protection agency and university
1 students. Vorth Carolina.
1
1 iti TOSS; lorrn cuoiiwi; BLOOD;
I BIlSVBERni BETBOOS; CBLO8IIE OBG1BIC
| CCtPOOIDS; CBIOBOBEB2BWBS:
| BIIICB1050BIIZEIE: POLTCHLOIII1IE9
I ciPBirrts; popoimoB ETPOSBBE
i
IEFEBEBCE

Bristol, D.V.
1980
EP1-600/1-80-036, *0
pp.





















Cjclohnane.  ,2.3.4.S,6-hezacbloro-, ganna-  (8 CI]
Crclohezane,  .2,3,4,5,6-hezachloro-, (1alpha,2alpha,3beta,*al;ha
-------
 Crcloluave.  f,2.3,*,5,<-aexacaloro-, gmmmt- (8 CI)
 Cyclohexane,  l,2,3,*,5.«-a«acaloro-, f1«lpk«,2alpha.3bata,4«lpk«,5«lph«,«b«t«)-  |» CT)

CS-B6-C16
It 290.95, BP g-aua-isoser crystals 112.5 C, SP 323.• C,  176.2 c it 10 mm Bg.  TP 0.1« •• Bq at *0 C
                                                                                      (COETIBDED)
IIS5BZ
3878
IBlOtiC
fluid
3879
Blood
3880
Blood.
s«ma
3881
float,
vbole
IPOSDBS BOVTZ




lEaimciL
SETS CD
-EC
8C-BC
oc
SC-IC
B0SBSB
F CIStS

25
IS
10
a) 2 of 19
b) 29 of
SO
c) 28 of
28
a) 33
b> 11
11(61
9-61 ppb
) 7-39 ppb
I 15-75 ppr
1 W-136 ppb
a) 2.1-6.7 ug/1
b) 3.6-30 ugA
c) a. 5-98 ug/1
a) 0.1-0.6 ng/g
b) 0.1-0.3 ng/g
Bill 1 CEIIB1L XEFOBB1TIOB 1 lErElEICB
1 1
1 1
1 1
7.12 ppb 1 50 positive speciMBS I Saxena, I.e.
Geoaetric I I Seth, T.D.
1 Pregnant soaen, siiilar ID 1 Bahajan, P.I.
1 locioecoaoalc level and dietary 1 1980
1 habits, lo occupational or 1 International Journal
1 accidental exposure. LUCXBOV, India 1 of Environmental
1 ' 1 Inalytical Chesistrv
I flSTICIDlS; CHIOBK1TED HTDBOC1BBOBS; I 7:285-251
I CBLOBIJB OBGltTC COBPODIDS; ODD; DDE; I
1 Ell: IIDIl; FBE6I1BCT; 1B1IOTIC |
1 ftOIB; P11CIBT1 |
1 1
1 1
) 18.9 * or - 8.8 1 a) Controls, full-ten pregnancies I Sanaa, B.C.
ib | t) ire-tern pregnancies 1 siaaiqai. fl.K.J.
1 39.7 « or - 1*.3 I c) Spontaneous abortions at less than I Seth. T.D.
pb 1 8 «k | Krishna Haiti. C.B.
) 73.3 » or - 32.2 I t BhargaTa. l.K.
ppb | icalthYf non-expose4, pregnant toaen. j natty, 0.
I ages K-32 TT, InSia. | 1981
1 1 Joamal of Analytical
1 IIDH; 4BOBTIOS; 1DHUS; TITOS ; | Toxicology 5:6-9
1 BLOOD; 711CIR1; CORMB1TITB |
1 tfllTllTIOIS; CI10BXI1TBD I
1 BTCBOCllBOS; CB10KIBB OXS1BIC |
1 COBtOOBDS; I1SECTICID5S; P1SHCIDES; |
I IBSTtCIIB 11SIDOIS; POPntaTICI 1
1 UPOSH1B; P1I6B1BCT |
1 1
1 |
a) 3.8 vg/1 1 at General population - continental 1 K rant hacker. B.
b) 10. » ng/1 I seath (urban) | llebic-Kolbah, T.
c) 26 og/1 I t> Sxposei workers - continental 1 Krall, B.
Geoietric leans | aorth (orban) | TkalceTic. B.
1 e) IzposeS workers - continental I Reiner, B.
1 scuta | 1980
1 1 International archives
1 General population, ages 6-79 yr. I of Occupational an!
1 Ceeupationallv exposed workers, ages I Environsental Health
1 20-C2 yr. Yugoslavia. I (5:217-220
t TUGOSltVIl; BLOOD SETOB; CBLOHIB1TED |
1 BIDBOC19BOIS: CHIOBUS OS61BIC 1
| COHPCWKDS; HDD: DDE; DDT: 1
I BIIlCHIO8OCyC10BEIlBI: PISTICIDHS; |
1 CCCOPITIOBU HaZlSDS; PESTICIDE I
I BI5IDOIS; POEOIATIOI EIPOSDBZ; ROB11 I
1 1DTIS; 18B1I 1BE1S |
1 1
1 1
a) 0.2 ng/g I a) tove Canal residents. 21! (7) | Bristol, D.I.
b) 0.2 ng/g \ positive I 1980
t b) Volunteers. 36" (») positive | ISI-600/1-80-036, 40
1 B»ge ana nean of positive sasples. I pp.
1 lilit of neasureaent, 0.068 ng/g I
I Closely latched, sinaltaneonE control 1
I saiples were not provided, for 1
I analysis along with those frcs the 36 1
1 love canal area residents saapled. 1
1 lacking seaningful control or |
1 literature data relative to the I
1 significance of the low residues 1
1 found in the field saaples analyzed, I
1 ao definite conclusions can be drawn |
1 fros the results reported. I
1 1
1 eaployees of the Environaental 1
1 Frotection Igency and university I
1 students. Sorth Carolina. 1
1 III TOBK; BOBTR CaSOLIBl: BLOOD; I
1 MkSnREHERT IBTBODS; CRLOBIBE OBGAHIC I
1 CCBPODIOS; CBL030BEBZ3BES; |
1 BITlCRLOBOBtlZSRE; PO1TCBLOBIBATED I
1 EIPBIWT1S: CCPHL1TIOB EXPOSOIt! |
(HIT P»S!)
-------
     Cyclohexane,  1.2.3.>.5,K-heiachloro-. gam- (8 CI)
     Cyclokexane.  1,2.3,a.S.6-lieiachloro-, <1alpha,2alpha.3b»ta,(alpha,5alpka.6beta)- (9 CI)

     CC-IC-C16
     II 290.85,  BP ganna-iawBer crystals 112.5 C, BP 323.* c,  176.2 c  at  10  m*  eg.  TP 0.1* » Bg at «0 c
                                                                                           (COBTIHUED)



I
1
1
1
1
1
IIS30!
3»82
Bilk
3883
Placenta
388* I
Placeata |
I
1
EXPOS9IE IOOII
Ingest ion
1
1
1
I
1
1
numcu
IUTHCD
ec
ec-sc
oc-xc
IBH8EB
OF CIStS
a) 21
b) 2*
c) «5
d) *S
50
) 25
) 15
> 10
BUGS
a) 0-0.061 pp.
b) 0-0.270 ppB
c) 0-0.270 jpe
A) lot given
62-1631 ppt
) 2-23 ppb
) 7-*1 ppt
I 10-6 6 ppb
Bill | SEBI11I IIFOtBaTXOI | BBPEBBtCE
1 1
1 1
a) 0.011 ppa I a) (oral Bothers, fat basis I Pozo Lota, B.
b) 0.037 PPB 1 M Orbaa aotbers, fat basis I Herrera Karteache, a.
c) 0.025 ppB | e) 111 Bothers, fat basis f Polo Yillar, 1.1.
i) 0.000* ppB I d) 111 Bothers, .hole allk basis I topez-Giaenez, B.
1 Data for sni of all pesticides and I Jodral Tillarejo, 9.
I ccifarisons vita Tains of other I Iglesias Perez, J.
1 laresttjaton qlven | 1979
1 1 Berista Sspanola de
I Inrsiag aoth«rs froa Cordoba region, I Pediatria
1 SfaiB | 35(206) :93- 110
| SF1H: IDOLTS; HUE; CHLOIIIZ OBG1IIC I
| COIPOmiS; PISTICIDES; IGBICDlTrei; |
| iUSlL »B!IS; VBB1I aR31S |
1 1
389.6* ppb I *l positive tpeciMBS t Saxena, n.c.
SeoBetcic | I Seth, T.D.
I Freaaant noaan, siaiiar in j Bahalan, P.I.
1 aceioeooaoiic level and dietary I 1980
j cabits. no occupational or I International Journal
j accidental exposm. Lucknov, India 1 of EnTironaental
j 1 analytical Cheaistrr
| flSTTCIDIS; CHLOSIlllTSO HTDBOCUBBOKS; | 7:245-251
I CEIOBIIS OB«I1TC COBPOOUPS; BOO; DDZ; I
j CtT; IIOII; PIE6I1ICT; 1BIIOTIC I
| I1UID; PlICIRI |
1 1
1 I
) 8.9 * or - 4.3 ppb | a) Controls, fall-ten pregnancies I Saxena, B,C*
) 20.* * or - 8.8 j i) Pre-tera presiaancies I Siaalqui, S.K.J.
pb | c) Spontaneois abortions at less than j Seth, T.D.
) 30.6 » or - 15.5 I 1 »k (inclad«s fetus) I Krishna flnrti, C.B.
pb I I Bhargava, a.K.
I Bealthy, non-exposed, pregnant voaen, 1 Rutty, D.
I aoes 18-32 jt, India. I 1981
I | Journal of taalf tical
I IIDI1; « BOB! 10» ; aOOLTS; FETOS; 1 Toxicology 5:6-9
| EtOCD; PI1CIIT1; COBPJS1TITE I
| ITJLOITIOKS; CHLOEIIaTED I
1 BIDBOOBBOJS; CHIOBIIE OBGtllC 1
1 ccnpotnos: IISECTICIDSS; PESTICIDES; I
I FISTICIDt BESIDDES; POPDL»IIO» 1
| tlPOSDBE; PBE6I1ICT I
1 1
CTdoaexagel
1C8-93-0
C6-H12-0
II 100.16, If 2* C, BP 161.5 C,  TP  1  BB Bg at 21.0 C
TISSUE
3885
Ereati



BIPOSBBE BOUTI




iUIITICal
IJZTBOD
SC/HS



OF C»S!S
8



»IGE
lat detected-I.C ng/hr


(MT.1
1E11
0.5 ua/hr


S»GE)
Glimt IIF01I1TIOI
CCBcaul related to aornal
netabolisn. lo other details given
Cryogenic saapling teehnigae.
Sealthv ailitary and civilian
enplorees, D.s. lir Force School of
lerospaee iledieine, ages 23-*7 yr. 3
SBOkers.
EtlTWES; CBIOBUATSB HTDBOCaDBOIS:
CBIO'IS* OSGIHC COBPOniDS;
IBI1TH: aLCOBOLS; TBT1S; AEHITS

BEFE8EICE
Conkle, J.P.
Canp, S.J.
Belch, B.E.
1975
archives of
Environmental Health
30 (2): 290-295



-------
CjcloaeiMol
1M-tJ-0
«-II2-0
M 100.1C. tt 2« C, 0 Kt.5 C. T*  7 M V? at 2t.O C
                                                                                      (COBTHOED)
1I5SVI
3866
Breath












IWOSOSI BOOT*














iBunicu
BBTBCD
cc-»s













B01BCB
or cisss
S* (387
saaples)












MBGI
lot girea













BB1B
2.6 (9/1
eeoutric












mnu iBfosBivxoB
Manna at 25 C and 760 u 14
«5.6» occurrence
loier and upper oae-Sigia Halts 1.03
aid <.« no/1

Bealthr, 19-35 TC old, a«»sw>kii<|.
vrtu blacks and caoc»siana.
Chicago, U. Blqiaiy conttollei
aifctiaaital eondltioaa.
miTE; ticcHLs: iitisois; IDQHS;
CBLClIIaTID tIDiOClIBOlS: TOHTI1!
CIS1ITC COSfCtWDS; BEllTB BltlBBS;
1I11I1TIC1; BSTlEOlISfl; BniBOlTTIS:
tcraimoi inosoM; TUB in »BE»S
1E7Z2EHCX
Kratoszinaki. B.I.
Bnuaan, G. a.
O'Hsill, a.j.
1979
Jovrnal oX inalrtical
Toxicology 3:225-23*








1162-K-8
Cn-H12-06
Bl 312.3. » 268-269 C
                                        <1)b«BiopTra»-1.11-aion«. 2.3,6aalrha,«aalp1ia-t«tcatiTdro-«-Mta(UT- (a CI)
                                                                                                            )- (9 CI)
TISSHI
38)7
Hood.
EtIM


BUOSOIE BODTB
laqastion


llaLTIICll
8BTHOD
BSLC
IS


•oHtm
or cisis
1


files
lot applicable


•nil
3.39 »q/al


GT1EB1L IIPOlRaTIOI
CB adaissioD. itlatoiin aoarce
•HkBOII.
31 it old black patlmt with hepatic
carcinoaa.
at latoiia-lB(air«d iaaone ceepoaoe.
line eaaccE. Clotting tile
alfeetal, deitt caaaad bf heaorrfcaqe
altar ncqecf.
JtClTS; C1SS EISIOIIBS; IBOFUS9S;
HOOD SEBTra; ITLatOIXIS; CIBCIIOCBII;
IttU« HITlBtS-. IOOB COHTIHIIVTIOS
1BFIBBICB
tr«r. B.S.
Bljes, 1.1.
1980
ZBTir<»Beiital Be search
22:«00-ao3


             *. latkTl-
  «€-37-7
  C«-B12
  El e«.1«,  HP -H2.3 C, B? 71.8 C, TF 100 la Bo. at  17.9  C
IISS01
3888
Breath

1


iBiinicit
BETBOD
OC/HS

BBBBSS
or CISES
8

IUGB
Bat detected-11.0 ng/hr

B!i« 1
1.5 ag/hr


Ccifonid related to nocaal
•etabolisi. fa other details gives
CXTogealc aaipliag tectalgM.
BcaltliT ailitarr and clTillaa
eeplOTees. o.s. lie TOTCC School of
lecospaee RedleiBe. ages 23-47 jr. 3
tmiBSS; CSIOBIBITEI BTDBOC1BBOIS:
CBlOtIRE OB6UIC COBFOWDS:
CBIOBOBEBZEBIS: FLOOBII! COBPOVBDS;
IltlTH; HCOBOLS; TEI1S; 1D01TS
BBFBIEICE
"conkle, J.P.
Caap, B.J.
Belch. I.E.
1975
IXChiTCS Of
OriroBaeatal Health
30(21:290-295

-------
     C5-B10-0
     II as.13, BF -19 C, BP 139.5 C
T1SSTII

3889
Breath








1
1
!
I ElPOSmi BO1TZ
1
1













1 lliLIIICtt
1
|
I CC-BS
1
(
f
1
1
I
t






IIXBE1
OT CtSBS

5« R87
saaples)











BJISI

lot gir«












BEir

0.329 ng/1
SeoMtric











CXinil II'OMITIOS

Beasorea at 25 C aid 760 is Bg
8.5V occurrence
lover and upper ane-Sigsa Units
0.0«9 and 1.59 ng/1

aeilta-r. 18-35 vr old, oonssoklng,
oilsn Hacks aid Caucasians.
Caicago, II. BigidlT controlled
•npcrineatal conditions.
E9HTS: tlCCCOLSj 1ILIIOTS; 1DVLTS;
CB10BIUTID BTDBOCaBBOK; lOXaTILI
cosine coftants: mm BIZAEBS;
IBRIUTIOB: BETIEOI.ISB: HSTisoirrss:
POTULtTtOI ZIPOSD9S; nBS»» »EE»S
JiriSElC!

Kcotoszvnski B*t
Bma«aaf G. H.
O'Rvill, B.J.
T979
*7&QfBa:2 0-f AoalTtlca]
loxicologv 3:22S~23«







   Cjatiu
   ;«64S-67-»
1
1 3890
1 Kail
f



J
1
|
1
j EXK>5Sft£ BO ffll
1
'








1IU.TTICU.
JSTBOO
ColorlsetrT








OF C15SS


1
1
1
I
I
1
J
1
BUS!
a) 10.6-16. 2S
1) 10.7-is. »jr
zirr vt







1 Mli
I
a) 13.3 » or - 1.61
b) 13. S * or - 1.««
Dry *t





1
i
G11EB1L irFOBIaTIO*
a) Bxposed verk«rs
t) Controls
to association betveen dnratios of
exposure and crstiaa content.

lork«rs, 22-52 11 olfl, in vanaiion
factory, rinlaad.

IB! tO tCIDSj OCCVP1T10B1L BHASDS;
FCFDUTIOI SIPOS01I; I1ILS; 7IS11BD

lEffBncl
KivillotO, *.
Fakarlnen, 1.
1980
International Archives
of Occupational aai
•6: 179-182



112-31-2
CK-B20-0
H 156.27, H -5 C,  BP 2*3-209 C. TP 1 •* Hff at 51.9 C
IISSOB
-
3091
Breatk












zzrosasz soni














1 UI.TTICII
SC-HS













or cis is
M 1387
saaplee)












IU6E
Bot given













*"'
0.261 ng/1
seoxatric












GE1IS1I IirOBSaTIOB
Bea tared at 25 C and 76D n Bg
5(. 1* occori-ence
Icntr »nJ apper oae-Signa Halts
C.0t7 an$ 0.700 nq/1

EealtkT, 19-35 rr oie. aonsnoking.
ntlan blacks and caacasiana.
Cblcaqo, II. EiqidlT controlled
•ipcriaeata) conditions.
ElflTH: IICCBOLS; IlLHOIS; iDOlTS;
cnoilRaTED ETDIOCkVSOBS; TOUT RE
CIG1ITC C09KOBOS: l^alTB ElUEES;
IIHltlTIOl-; BITieolISIj BBtlBOtrtSS;
POT1HTI01 1IWSB?E: 1JBM 1B11S
ISFE1EBCE
KrotosxT&skl, 3. E.
Brnnean, G. a.
C'leill. B.J.
1979
Journal of analrtlcal
Toiicoltxji J:225-2I«








-------
 12*-ta-5
1X exposed residents had bnrnllke
skin lesions, sone with cbloracne
ITILT; IDOIfSCETITS: MOLTS; US!
EISTOBItS; CBlLBSei: 1DIPOS! TISSO!;
EBtll; KIDIITS; LITIB: LDB6S;
fllCSHS; RI11TH HnllSDS; IVDUSTBIU.
1CCIDHTS; IIOPLaSSS
-
IntopST tissue. Bepre seats cat
recovery
?•• it oil vonaa »ho died of
pancreatic carcinon 7 no after
industrial accident in Seresc, Italy,
111 exposed residents had bernllke
till lesions, sose "ith caloracne
IT11T: IDOllSCeilTS; IBOtTS; CASE
BISTOBIBS; CBItDSE*: iBIPOS! TISSUE;
tBi»; moms: LITIB: LDBSS;
EHICBI15; BULTB BnZ»BS; IBDUSTEI1L
UflBEICS I
Seggiani, 0.
1990
Joarul of Toxicologv
and SnTironnental
Health 6:27-43


' Beggianl, s.
1980
Joaraal of Toxicology
and tnvironnental
Health 6:27-13


                                                                                        (•SIT PICK)
-------
Dlbeniofnran. 2,3.7,8-tetrachloro-
•1J07-31-9
C13-B«-Cl«-0
BR 306
                                                                                      (COSTIBUBD)
TISSBB
3695
Kidney


3896
liver


3897
lung


3898
Pancreas


EIMSOSB BOOTB
Xngestion


Ingest ion


Inqestion


Ingestion


IBalTTICaL
RETROD












RUBBBB
Of CASBS
1


1


1


1


BUGS
Rot applicable


Mot applicable


lot applicable

. _ _ _
lot applicable


BBaB
O.OH ppb


0.15 ppb


0.06 ppb


1.04 ppb


GEBEBaL IBVOBRaTIOB
Autopsy tissue. Represents 60*
recovery
5? yr oil HOMO who died of
pancreatic carcinoma 7 BO after
industrial accident in Seveso, Italy,
1976
All exposed residents had burnlike
skin lesions, soae vlth chloracne
mil: iDOtBSCBBTS: IDOI.TS: C»SB
FISTOBI8S; CBILDBBB: IDIPOSB TISSUE;
tBalB; KIDBIIS; 11788; IHBGS;
EISCBS»3; BBILTR HIZISDS; IIDDSTBIaL
iccioirts: iiopLaSRS
lotopsr tissue. Represents (VI
r«eo*ery
^5 yr old voian who died of
pancreatic carclnoia 7 no after
industrial accident in Seveso, Italy,
t976
All exposed residents had bnrnlike
akin lesions, soae with cbloraene
ITUT; IDOLBSCBBIS; 1DOLTS; CISB
BTSTOBIBS; CBILDBBB: JDIPOSE TISSUE;
EBilS; KIBSBT3; IITEE; LOSGS;
flBCBBSS; BIIITH BaZtBDS; IBDOSTBIaL
ICCIOSSTSJ IBOPLtSHS
•ntopsy tissue. Represents 60f
recoTery. Calculated total body
atount ao aq
55 yr old votan »ho died of
Jancreatic carcinona 7 «o after
ndastrial accident in Seveso, Italy,
1976
111 exposed residents had burnlike
skin lesions, soae «ith chloracne
ITalT; IDOIBSCERTS; ADULTS; CI5E
alSIOBIBS: CBILDBBH; ADIPOSE TISSUE;
IRtIB; KIDBETS; LIVBB: 10BGS;
PlRCBEaS: HEALTH HAZARDS; IBEDSTBIU
ICCIDB^TS: BtOPLASnS
Autopsy tissue. Represents S9¥
recovery
?5 yr old voian «ho died of
pancreatic carcigoaa "> no after
iodoatrial accident in Seveso. Italy,
1S7«
ill exposed residents had bnrnlike
akin lesions, soae with chloracne
ITALT: ADOltSCERTS; ADULTS; CASE
HISTORIES: CBILDBEB; ADIPOSE TISSVE;
ESAU; tlOIBIS: LIVEB; LOBGS:
EJBCBSAS: BIIITH 8ATABDS; IBDOSTBIaL
aCCIDEBTS: BBOPLASBS
BErBBEBCB
Peagiani, 6.
1980
Journal ot Toxicology
and Environmental
Health «:27-«3


tleaolanl, 6.
1980
Journal of Toxicology
and Environmental
Health 6:27-43


Beggiani, G.
1980
Journal of Toxicology
and Environnental
Bealth S;27-a3


Beggiani, G.
1980
Journal of Toxicology
and Envlronoental
Health 6; 27-03


                                                                                                                                                                                            oo
-------
 Cit«tyliilB«  (8  CI|
 T-Htantaiat. a-tvtjl-  (9 CIJ
 111-92-2
CS-«19-«
II 129.2*. Bf -69 to -59 C. Sf  155-ISO C, TP 2 ma  Eg at 20 C
TISSUE
38*9
Imtt












EXPOSOIE MOTE













1IUTTIC1I
BKBOD
CO-SS












B0HBBB
or cisis
5* (387
aaaplea)












I1IBE
lot given












•Ell
0.218 ng/1
Geoaetric












GIIHII IfFOIBITIOI
•eanrei at 25 C and 760 mm eg
6.5» occicrcnco
loner aad apper oM-Sigaa Halts
0.043 »i 1.11 aaA

RaaltkT. 18-35 Tt oil, nonaaofclnq.
vctu blacks and Caucasians.
Chleaao, 11. Siqidlr controlled
cxperiMital conditions.
E1IITH: ILCOWtS; IILXIOIS; tDOlTS;
CILOIlnTCD ETDBOCtlaOHS; T011TIIS
cseanc concnDS; IULTB HITJEOS;
mtunci; aiTiEOLiSB; BITIBOLITES;
iCIOtUIOl IIPOSBtS; QBB» »BUS
B8FEEE1CB
Krotoszjnaki, B.I.
Bconeau, G.S.
O'Kill. B.J.
1979
Joarnal of inalytical
Toilcology Js 225-21*








          lM.  l-nittoso-  (« CI)
Ittbaaaila*. 1-MthTl-I-iiltresa- (9 CT]
C2-1S-9
CJ-B6-I2-0
•t 1«.1.  B» 152 C
IIS5V1
3900
Blood









iiposnBE BO or i











iiunicki
BRBOD
GC








t
1
B08B1B
OF C1SIS
a










IUGI
< 0.5-1.3 »9/al










Bill
Bot giTon










GEIIUL IirOSBlTIOB
tcfoce and after a«al iiqh in nitrate
aid aecoadari aaiaea. Bo siqii:icant
• ff«et of teal. 32 saaples.

17 and 30 yr old lapaacae.

Possible BitiMailna foraatiao in
lower SI tcact.
JI»1B; ID01TS; HOOD; OUTS;
raavtts; in«osiB»csi HIHEOLTTSS

BlfBBEICE {
1
1
Taaaaoto, B.
luada, T.
Taniiura, 1.
1980
rood and Coaaetica
Toilcoloqi 16:297-299





  to4«cau«
  112-M-3
  C12-826
  8B 170.3, B» -12 C, B? 216.2 C, TP  1 aa  Hg at  «7. 6  C
TISSUE
3*01
Breath










BXBOSOBE BOim











BXTBOD
sc-as










IOBBEB |
or CUES
5» (3(7










MICE
Bot given










SEAM
0.130 og/1










GEEIE1L IBFOIBKIOB
...
tenure! at 25 C and 760 la Hg
36.2* occurrence
to»«r ani npjer oae-siqaa Halts
0.03* and O.W1 »
-------
      EC0079 (Id poatlnqs i» CHElimj.
ITSStJ!
3902
Orise
EISOSOE1 BOItl
Ingest! on
IIUTTICU
BETHCD
Badiosetry
TOSSES
or cisss
«
B«GS
0.407-0.022!
I nilB
1
1
1
0.0161
cziiBii nroiRHiow
* excreted in urine daring 96 hr
after 50 iCi. Bost of dose excreted
III faces, blood negative.
EcaltliT volunteers, 22-39 jr old.
FCOI JDKTrTES; FOOD PBESBBTMIVES:
KT»BOIISI; JSIJtl: lEIZOfl
SEFIBISCE
Valsan, P-B.
Carter. D.E.
Prerson, B-i.
Ealladar, S.C.
1979
rood and Cosmetics
Toxicology 17:201-203
	 I
     000*78  (lo pcatinqs la CHUIIWI).
irssmr
3903
Urine






( txtosns soarz
Ingest ioa






	 1
HETHOD
Badiosetrj





t
t
IVXBSS
OF CASES
6







lltSI
0. 028-0. 06JT







JIEJII
0.0««







cittau, iirosHjTioi
1 excreted daring 56 hr after SO nci.
Bost of dose excreted in ieces, blood
negative.

fOOT IDBITITIS; POOD PBSSIRIJTITIS;
e(T»BOI,ISI!; OKIBB; 1EIEOH


MMZZWU
Ralsan, P.D.
Carter, O.E.
Brerson, B.t.
Balladar, S.C.

loot and Cosaetics
Torlcol'igy 17:201-203

   7S-1B-J
   C2-B*-C12
   «i S9.0. .T? -97.7 C, BP S7.3 C, T* 230 •> ffg at 2i C
1 TISSUE
1
1
1
1 390*
1 Breath












JIPOSORl FOTI!















I 19UTT1C1L
| BtTSCD

OC/IS












'
I 9tllBZE
I 07 C1SIS
1

8













| BIIGE
1
1

Hot applicable












I
1 IEK
t
1 trace aiout
|
1











1 GiitFiL riroauTror
1

CeiB»nd froi aikiova origin, la
ether details giT«n. Detected la
only 1 «61ect
Cryogenic saipllag teehnigne.

•ealttr illitarr and civilian
employees, O.S. lir force Scaool of
leroepiee ledicime, ages 23-«7 jr. 3
Eioken.
fllllttS; CBIOBIHTEC Bn»OC»BO>S;
C81OEH? OBGtUC COSPOOWDS;
CBLOioanzEics: FLTCBII: COBKUHDS;
EKHTI: IICCBOLS; T»1S; 1COITS

SErESSJCE

Conlclev J.P.
Caip. B.J.
•elch, B.E.
1975
Archives of
EBTiEoaaeittal BealtL
30 (2): 290-2 95






I
1 I-'
! S
i ^^














Ethane.  1,1-aichloro-2.2-bi9fp-clilarpaeirl)- (B CI)
Eenien,  l.l'-fZ.Z-dicltlocoethrlideaelbisia-chloco- (9 CI)
7Z-5«-«
CK-B10-CH
H 350.S6. BP 221-222 C
tISSOB
3 SOS
adipose


\
BIPOSDBE BOOT!





aUlTTICIL
HETflOD
OC




IO93EK
or CASES
60




111 1
I \ I I
\ \ \ \
I1IGI
< 0.10-1. 05 Fpa





SE1I
a. 27 pp»





|
t
\ » » It 1
* .-»- . _ i 11 i
eEIEllL MPOtUTIOI
Feriphenl kidwr ttt, rogtine
pathological exaalaatio»

«ge« 6 14-92 rr. S«liin«
BltBITTS; inTOPSlES; 19IPOSI *ISSHS;
noaccmm&im ; TBSTICHIB,SS BBB;
Kit ACT; DIlLmlB; S5TTIC91OB
tfOTTDl" BnftCHLOROEmm* LX10ME*
•EFE8EICE
Dejaxclciieere, ».
Steacbaat. 1.
Terstraetm, H.
Kips, «.H.
Toxioological European
eesearcb. 2 (2) -.93-98


CBic»t« o*»nc coBtovms' * i
i
l«M *«H 	 —
-------
mate, 1,1-diciloro-2,2-bi«(p-ctlorplienrl>- (« CD
ecBte», l.t'-K.Z-dlchloroetbrlia'eMlblAp-ckloro- fS CI)
7i-5«-»
C«-B10-C1»
El 350.46,  at 221-222 C
                                                                                     (COITTKJED)
nssvt
}»«
iniotic
flail
3907
float
3401
Blco-5.
«Una
3109
Blood,
aeraa
IPOSTOE coral




luimcn
BRHOD
OC-SC
SC-JC
GC
OC
IDIBEB
OF C1SSS
0
t 25
o> 15
CI 10
•1 139
b) 175
C) 199
d) 210
at 31 of
•1
b) 20 of
««
cl 10 of
19
at 35 of
50
a) 8 of 2
MICE
24 pp*
1 lot 4etectable-23 ppb
) lot o«tect»ble-35 ppb
) lot detectable- «32 ppb
a) 0-1.3 PFt
b) 0-H.S ppt
c) 0-5.0 ppb
d) 0-1.2 ppb
a) 0.5-2.1 ng/l
bl 2.5-23 09/1
c) 3.«-17 09/1
d) 3.1-318 ng/1
e) 3.5-11 as/1
Uil | SSIEE1L IJFOSB1TIOI I B!FEB!»CE
1 1
1 1
99 ppb 1 10 positive specimens I Saxena, B.C.
ontcic 1 1 Setl, 1.0.
1 Pregnant vonen, sinilar In f Hahajan, P.L.
1 tceioecononic lerel ml Sletarr 1 1910
1 tabits. »o occupational or 1 International Joaraal
1 4ccia*ntal eiposnre. Locknon, India 1 of E»riroua«ntal
1 1 Inalytlcal Chealstry
I risTicists; CBTORIHITSO BTDBOCIBBOHS; i 7: 2*5-251
1 CH10HI1! OSG1IIC COIMOTOS; COO; DDE: I
I tn; HDII: PRIGIUCT: IBIIOTIC i
1 MOID; ?llC!m |
i i
I i
1 6.9 » or - 7.9 ppb 1 a) Controls, Cull-ton pregnancies 1 saxeu, B.C.
! 15.2 » or - 12.5 | t) Fee-ten pregnancies 1 si.41i.gtii. I.E.J.
pb I cl Spontaneous abortions at less than | Setb, T.D.
c) 65.5 + or - 129.* 1 « »V I Krishna Rorti, C.5.
pb | | Bbargata. I.E.
1 H«alt»T. nan-exposad, pregnart mien, 1 Kntty, D.
1 ages 18-32 yr. U41*. | 1981
t 1 Journal of Inalytical
1 IlDIl; HOBTIOI; IDHT.TS; IITTIS; | Toiicologi 5:6-9
t E10CD; •HCBITl; COBPIBITHE 1
t 11U.H1TI01S; CBLOSI11TED 1
1 BIDBOCUBOIS; CBLOEII! OBG1IIC I
1 CCBPOTIOS; 1ISECHCIGBS; PISTIdDES: t
1 FISTIC1DI T.IS1BDES: MPUllTIC!! I
I ixcosa»; pBtenict i
i i
a) 0.1 ppb 1 a> Boral tlacks | Finilea, J.
b) 0.» ppb I t) ncfcu blacks I Priester. I.I.
c) 0.3 ppb 1 c) Qrban Caucasians | creason, J. P.
1) 0. 3 ppb 1 a) Boral Caucasians t Ha user, T.
1 I Pinners. T.
1 Ocbaa an! rnial cesltents of SC, I Banner, 6.1.
1 infants, children, adults, eiaerlr- 1 1972
I 1 lierlcan Journal of
1 SOOTH CUtOIIBk; 10VLIS; CHHCSE1; | Public Health
1 SICIU 5TODI1S; BIOO1 PUSH; | 62 (5) : 6*5-651
1 CCHftSITITE miOlTIOBS: ODD; ODE; |
1 ttT: DISIDBI); PESTICIDES; |
1 tCLTC9LOsn»ED BIPHEITLS; 115 1
1 tctiUTioi: fcoo coitiaimiioH; i
I P'StlCIlt ItSIDBES; P050LITI01! |
1 MtOSSBE; «VB1I 1HE15: OBBU IKllS |
1 1
1 1
a) 1.1 us/1 1 a) General popalation - continental I Kraithacker, B.
b) 6.4 ug/1 | central (rural) I llebic-Solbah, T.
c) 5.2 ng/1 | t) General population - island \ Kr«l1, n.
11 11 ug/1 | (coral) | Tkalceric, B.
e) 6.2 ng/1 I c) General population - continental | lei nee, I.
GeonetrLc aeau I contb (urban) | 1980
1 d) Stpoael ocrters - continental | International IrchiTes
1 north (urban) | of Occopational and
1 e) Exposed »crters - continental ( Environnental Health
1 icuth (urban) | 95:217-220
1 1
t General population, ages 6-79 yr. |
1 Occipationally exposed workers, ages \
1 20-62 rr. Tagoslavia. t
1 1
i TtJsesLirii: siooe stMH: CBIOSIHTED i
| gTOKOCiBBO'S: CEIOEIK! OPG1IIC |
1 CCBP01HS: DEE: DOE; DDT: PESTICIDES: |
I eiiicaLOECcYCLottmii: OCCOPITIOHI i
1 BI11BC3; FtSIICIDl HESIDUES; |
1 fC?0HTIOJ SirOSOBE; BOail UEHS; |
I mm issis i
1 1
(1EIT PiSE)
                                                                                                                                                                                           NJ
-------
Itaaa*, Ifl-dichloro^^-bisfn-cUorphwyl)- (8  CI)
Icrane, 1,1'-(2,2-dlcia.oroethTUa'en«)nls(*-chloro- (9 CI)
7Z-5«-S
CH-B10-C1*
IE 3SO.««, If 321-222 C
                                                                                      OS; ODD; 001; |
CBt! I»BI«: PBESIAICT: »H»IOTIC I
MOID; CtlCERl |
1
a| 25 a) lot detectable-* 1 ppb
b) 15 b) lot det«ctable-«2 ppb
c) 10 c) lot detectable-75 ppb
a) a.s * or - 8.3 ppl a| Controls, f all- 1 era pregnancies I Saxeu, B.C.
b) 10.7 * or - 10.7 b) Pre-ters preon ancles | siddiqai, a.K.J.
Ppb c) Spontaneoas abortions at less than I Seth, T.D.
c| 20-« « or - 22.8 9 «k (inclides fetas) | Krishna Barti. C.B.
PP* 1 EhargaTa, l.K.
Bealthr. non-exposed, pregnant w»ien, | ICnttj, O.
ages U-32 rr, India. | 1981
IIDI1; 1BOI1IOI: IODLTS; ?ITDS; [ Toiicology 5:«-9
EtocD: pticsiTi: cospiBiins i
ttlLOaTIOIS: CBI08II1TBO 1
ETseocitgois; caws IK osciaic i
CCBEOWDS: IISICTTCIDSS: PESTICIOBS; |
FISTIC ID I SISXDOZS; POPB1.1TIOS I
IlPOSmS; 7BESI1ICT |
1


M
N5
to
-------
 !tku«.  t.f.l-trlcaloro-
 71-SJ-6
C2-BJ-C13
n 133.»2. « -3fl.«1 c, BP 7*.1 c. TP too » 89 at 20  c
1ISSOI

341*
Bteatk










391S
Breath












siMsnn BOOIE



























i in men
IBTBOD
ac/is











QC'IS













nun
Of C1SIS
8











» (387
saiples)












IMGE

lot detected-1«0.0 ««/kr











lot giren













Bill

20.1 «g/nr











1.8 na/1
MOM trie












6Sl*tal tlFOBBlTIOB

Cciponad related to nornal
•etabolita. *o other details glren
Cryogenic gaipllag technique.

SealthT illltarr and civilian
employees, U.S. air Force School of
lerospace Dadlclae. aq«s 23-47 yr. 3
>*oter3.
tiizms; cnotiiniD iiosoctssoss;
CELOBIW oisinc coiMmas;
CILOBOKIZIIK: HVOSIR COH001DS:
IttKI; IICOBOLS; TEHS; IB HITS
Masaccd at 25 c and 780 •• Bq
21.7* oeenrteBce
Lo««c a«d ipper oae-Sigaa lilits 0. *2
aid 7.7 an/1

Bcaltkr. 18-3S TC old. aonsaokiaj.
ottaa blacks aid Caucasians.
Cfcicaqo. IL. llqldlT eoDtiollel
cipcrlmtal coaditiom.
HiiTB; IICOEOIS: iiLisois; units:
CHIOHHTID ITDBOClSBOIS; 7O11TH.I
CB61IIC CC8PCOIDS; SE11TH I1U8DS;
IlHlllTIOl: IR1BOIIS1: HET1BOLIT8S;
ccrmiTioi nposiii; eaTl)-2-(p-cUocoph«arl|- (8 CI)
 Kaxeae. 1-cUoro-2-(2.2,2-trichloro-1-(«-cilocopbenil|«tliTl)- (9 «l
 7t»-02-«
 C1*-B9-C15
 81  3S«.»9, EC 7«-7«.«> C  (coc)
                                                                                                                                                                                              to
                                                                                                                                                                                              U)
1ISSJB

3916
tlDlotlc
flail






3917
(load.
plasaa













EXMSin BOOTI


























1MLTIIC1L
RZTBOD
SC-BC








ec















miiBzs
or CUBS
so








a) 139
b) 175
c) 199
d) 210












BUGS

0.5-11 ppb








a) 0-2.7 ppb
b) 0-3.9 ppb
c) 0-2.7 ppt
d) 0-1.6 ppb












am

1.06 ppb
SeoMtric







a) 0.2 ppb
b) 0.* ppb
c) 0.2 ppb
1) 0.1 ppb












Gzmii iirosBiiioi

15 posltiTe «p«ciaens

tlegaaat voaca, siillai in
habits. Ho occnpational or
accileatal erposare. Locknoi. India
ftSnciDIS; CHLOBI1ITSD HIDBOCABBOIS;
CEIOBIIS OB61HC COBP001IDS; DID; DDE;
BtT; IIBI»: ciEeiiicT: IBSIOIIC
IIOID; PLicirri
at Snral blacks
t) Urban blacks
c) nrbra Caucasians
i) Bvral Caucasians

Urban and raral residents of sc.
infants, ckildrea. adults, elderly.

SOOTH CHClIll; 1B8LTS: CHILCTEB;
BICIJT. STUDIES: BtOOT) PLaSRl;
CCIPtDtTIfZ miOMIOIS; DDD; ODB;
Ctl; OTEIBBIB: PISTICISBS;
EOIICBtOBIHTTO BIPBfBILSi tl<<
EC11QTIOI: FOOD COIT»«H»TIOI:
PISTICI9I BESIDDIS; POPOL1TIOR
upasnB!: BOBIL isiasj OBBII nias
BEFEBEBCB

Sanaa. B.C.
Seth, T.D.
Hahalan. P.L.
1980
Internatiooal Joinal
of ^nrironnental
tnalrtical Cheaistry
7:2*5-251



Finklea, J.
Priester. L.E.
Creason, J.P.
Baaser* T.
Binners. T.
Eaaaer. D.I.
1972
taerlcan Journal of
Public Health
C2(5):6«S-6S1






(HIT P1S£)
-------
 Ithane, 1.1,1-trickloro-2-(o-chloropkeayl)-2-(p-ckloropli«Byl)- (8 CI)
 EeBxene, 1-chloro-2-(2.2.2-tricliloro-1-(»-chloropb«ayl)ethylj- (9 CI)
 789-02-*
 C1»-B9-C15
 81 35*.«9. BE 7«-7».S C (cor)
                                                                                       (CORIMIEO)
IISSVE

3918
Placenta









Exposure sotrtE











1BALRICAL
BETHOD
OC-BC









IOSBEB
OF CASES
SO









B1BGE

9-63 ppb









BE* I

«9.63 ppb
Geoaetric









GZIE1AL IIFORBaTXOB

20 positive speciMIS
Pregnant voneB, siBilar in
socioecoaoslc level and dietary
habits. Bo occapatiomal or
accideital exposure, tncknov, India

MSTICT9I5; CBLOBIBATBD HTDBCCABBOIS;
CELOBiit OIGABTC COBPOOBDS; COD; DOE;
CCT; nni»: PBSGBAICT: ABBIOXTC
flUID; PLACIITA
EErtiBBci

Saxena, B.C.
Seth, T.D.
Bahamas* P.I.
1910
iBtecaational Journal
of EnviroBaental
Analytical Chenistry
7:2*5-251



tthane, 1.1. 1-tricliloro-2,2-bis (p-chloropfceofl)-  (8 CI)
tcnsm. 1.l'-(2.2,2-trlchloroetfcrlWeB«)bi»(»-ctloro-  (9 CI)
58-29-3
CH-B9-C15
BI 3?*.59.  it 108.5-109 C. BP 260 C, TP 1.5X10(1-7) •• Eg at 20 C
1 TISSUE
1
1
1
1 3919
1 Adipose
1
1
1
1
1
1
3920
Adipose
3921
Adipose
EIPOSDIS BOOTS IIALYTICAL B9BBSB
BETHOO Ot CIS!



1
1
1
1
f
1
GC

1
60
7
BABGB

.20-3.70 ppl
t given
MEAI GBIZBAL IBPOBBATIOB f BEPEBEBCB
1
,._,.. 	 1
1
1
1. 52 ppn
1.4 * or - 1.26 ppn
1
B«vie* | Delchnann. I.B.
1 tlacDonald. I.E.
Exposed persons in the United states, I 1977
tfce setherlands, Sweden, Israel, I Ecotoxicology and
lapan, USSB, Poland, Seraany, India, I Environnental Safety
Bulgaria, Pakistan, Anstria. I 1:89-110
1
feporteJ cases of hypertension, I
CEGs, or ispairsent of neacosnscalar I
function after acute exposure to I
1 continatlons of pesticides, tat most |
1 data show no adverse effects after I
1 long-tors occupational exposure. I
JCSTBIl: BBIGARIA; GE8IA«r: IRDIA; 1
ISBAEL; JAPAI; BETHIBll-fBS: PAKISTAB; 1
tciiiD: BussiA; CTEDMI IBITED t
STATSS: ADIFCS! RSSffE: BLOOt; BLOOD I
PUSSA: BtOCC SEIOfl: !BrTBBOCr*!S; |
KOICOCTTES: BILKj It lit; SETIE8: |
BIALTB fAZADCS; OCCOPATIOBAl HAZARDS; |
PCPOLITIOK HPOS08E; XEOPLASBS; I
FISTICI9CS; CBI08IVE OSGAXIC I
CCIPOtr»DS |
1
Periok«ral kidney fat. routine ( De-jonckbeere, W.
Fatbologlca 1 examinations | stenrbant, I.
1 Terstraeten, E.
Ages 6 so— 92 yr. Belgian I Kips, S.B.
1 1978
!E1«IVS; AUTOPSIES: ADIPOSE TISSUE; 1 Toxico logical European
EIOACCISBLAtlOB; PESTICIDES; DDD; 1 Research 2 (2): 93-98
let; DDT; DiiiDaii: BSPTACHLOS i
ITOIIDf; BEXICnoBOBEBZEIE: 1IBDABE; I
CnOBIIB OEGAIIC COBPOHBDS |
Bospital patients | Inoae, T.
1 Abe, S.
Japan | Takanatsu, 8.
1 Aoki, «.
tOtT.CBLO^I«ATBO IIPBMTLS; DPP; I "liki, S.
BIXACBtOBOCTtClOBEIABE: BLOOD PUSBA; ) Fnlluara, K.
I'OPLASflS; JAP11; CAStBOIBTESTlnL | 1975
STSTW1; PESTICIDES: ADIPOSE TISSITS; I Tnknoki Helical Journal
1
                                                                                                                                                                                           to
-------
 ma»e.  l.1.1-triehloro-2,2-l:is(p-cliloropIi«»yl)- <* ci|
 e«a»l»r  1. f'-(Z.2f2-tricMoro«thrU*«»)l>i«t»-chloro- (9 CI)
 Sfl-29-3
C1«-«9-C15
fl« 35«.50, HF 106.5-199 C. » 2«0 C, TP  I.SXIOfI-7}  u Bg at 20 C
IISSBI 1
3922
1 1
1 1
| |
3923 1
Blood |
1
1
392*
Blood

!IM50ra lOBII
<



SFTHCD
SC-BC

SC-EC

in Bit
or cis is
l) 22
b| 1*
4 6
1) 6
» 6

a) 25
b) 15
O 10

	 iiiei i Bill BMIUI nroMinoi'" i IEFBBIJCB
! i
lot gives 1 a) 2.60 + or - 1.33 al Elderly >«• 1 BreTik. E.H.
lot gives 1 sg/kg ») Elderly «csen 1 Bjerk. J.B.
lot givsB 1 bl 1.86 + or - 1.»1 el Toang sen I 197>
lot givee 1 sg/kg «1 T.on»g >oa«a 1 Icta Pharmacologies at
lot gives 1 c) 0.95 * or - 0.26 e) levbocBs 1 Toxicologies
1 ,,/kg Perirenal tissue |»3(1):5>-«3
1 d) 0.91 * or - 0.61 197C survey. Significantly higher in I
I ag/kg elderly, particular IT in sen (P < I
I e) 0.75 * or - 0.56 0.051. Significantly lower levels in I
j i
-------
I thane. 1.1,1-triehloro-2.2-bi*(B-caloroph«Tl)- (8 CI)
Bentene. 1.1>-(2,2.2-trichloroethrlld*M)bls(*-ehloro- (9 CI)
•0-29-3
CW-B9-C1S
81 35«.50. BP 108.5-109 C, BP 260 C. TV 1.5110(1-7)  » Bg at 20 C
                                                                                     (COITIIOSD)

























1ISSIE


392S
Blood.
Flan*










392C
Blood,
plasaa















3927
Blood,
1 serai
1
1
1
1
1
1
BXKSOIS BOOTE

















111LTTICU
BETBOB














ec

1
t
|
I

1
I
1
1
1
1





1 ec
I
IUBBEB suet
or CASES

a) 27 a) Jot given
b) 16 b) lot given
c) 37 c) lot given










a| 139
b| 175
c) 199
d) 210














32 of
1
< I b) 8 Of 19
1 C) 17 of
1 ««
1 d) 32 of



1
1
1
1
1
1







SO
e) 7 of 28

















a) 0.6-28.2 ppb
b) 0.1-62.7 ppb
c) 0.1-6.6 ppb
d) 0-6.0 ppb



BE1I


a) 3.5 « or - 2.50
ppb
b) 4.7 * or - 5.53
ppb
c) 3.0 « or - 1.96
ppb







a) 8.8 ppb
b) 5.* ppb
c) 1.7 ppb
d) 1.6 ppb


entail itrosaiTioi i BEFESEICE
I
i
a) Hospital patients | Inoue, T.
t) Zsaciated persons j Ibe, S.
c) Ron-esaclated persons 1 takanatau, B.
1 »oki, ».
Japan I Biki, S.
1 rajivara. K.
lOITCBLOBIIITB) SIPBEITLS; DM; I 1975
BEIICBtOBOCTCLOBRlIE; BIOOD P11SB1: I Tnknoka Redical Journal
IIOPUSIS; JIPIB; G1STIOIITESTIML I 66(10:610-616
SISTW: PESTICIDES; IBIPOSf TISSUE; I
IITEB; KigitTS; 01EITUB |
1
1
a) (nral blacks I Flnklea. J.
r) Urban blacks | Priester, I.E.
e) Urban cancasians I (Treason, J.p.
4) Baral eaacasiais I Banser, T.
1 Binners. T.
Orban and rural residents of SC. 1 Banner. D.I.
infants, children, ad«lts, eldorlr- 1 1972
1 Aaerican Journal of
SOUTH ciaotm: IDOITS; CHILESEI; i Public Health
B1CI1L STODIES; BLOOD PUSH; | 62 (5) : 645-651
CeiPlBITTTI tYllDHIOBS: DDK: DIE; I
ttr: tnunii; PESTICIDES; i
EOITCBLOHIITID BIPBEBTLS; AIB I
| (CIITTIOB; FOOD COETMIBlTIOIi |
| PISIICID! RESIDUES: POPVL1TIOB I
| EIPOSUB!; BOMl UB1S; BUSH M»5 |
1
1
a) 1.1-5.3 ng/l a) 2.2 ag/1 a) General population - continental I Krauthacker, B.
b) 3.7-17 ng/1 b) 6.1 «g/l central (rural) 1 llebic-Xolbah, 1.
e) 3.1-39 og/1 c) 7.2 ug/1 r) Senacal popalation - continental I Krai-), B.
) 3.7-96 «g/l | d) 15 og/1 a««th (arban) | TkalceTic, B.
) 4.7-29 og/1 | e) 11 ng/1 e) General population - island 1 tteiner, EJ
1 Seonetric >eans (rural) | 1980
1 d) Exposed workers - continental I International IrcniTes
( north (urban) | of Occupational and
1 e) Ixnosed corkers - continental I Environeental Health
tenth (urban) I 05:217-220
1
Gmecal population, ages 6-79 rr. 1
Occapationally exposed workers, ages |
20-62 rr. Tngoslaria. 1
1
TOSCSHTIl; EIOOE SB1!IH: CELOEIIITES I
RTBtOClSIOIS: CBIOEI1! OBGIHIC |
ccnoowos: Dtt: DDE: ODT; i
ifitcRtoiccTcioBixm: PESTICIDES; i
CCCnPATIOIlI B13IIDS; PESTICIDE |
BISIDQES; POPO11TIOI SIPOS01Z; BBB»L |
IB IIS; ISBll UEtS |
(HIT PISS)
                                                                                                                                                                                        N3
-------
       ,  f.f,1-trical,oro-2,2-bis(p-ekloropa«Tl)- IS CI)
ttmutt,  1,1*-(2,2,2-trichloro»thrlU*a»)i>LsH-chJaro- (9 CI)
SO-29-3
CM-B9-C15
II 354.50, H 10«.5-109 C. 31 260 C, TP 1.5X10(1-7) mm  Bg at 20 C
                                                                                      (COITIIIBD)
IISSBE

3928
Blood.
senm























3929
Bilk










3930
Bilk





3931
Bilk












tlPOSOlE ROOTZ


























































i uimcit
MBTBOD1

























-
BO-EC

















GC-IC












BOHBSH
p cists


























10










25






a) 1»
b) 11
c) 10
d) 9












URGE



























8.0-135.4 no/kg










lot given






a) lot given
l) lot given
c) Rot given
d) Hot given












BEll | GHIUL IBPOBBlTIOl

1 leviav
1
I Zxposed perscaa ia the United states.
I tie letkerlands, Svedem, Israel,
I Japan, nssi, Poland, Gernany, India,
| Bulgaria, Pakistan, avstrie.
1
I teportea easts of kypertension.
1 elevated seen cholesterol, abnormal
1 IT.GS. or iapairaeat of nenronscalar
I fmction attar acute ezposare to
I conbinations of pesticides, bat cost
1 data shov no adverse effects after
1 long-ten occupational exposure.
1
1 ItSTBIa; BOieiBII; GEBBliy; mil;
1 ISBlEl; JlPtl; IZTEBBLllOS; PMCISTal;
1 iClalD; BOSSU; StEDEB; UBITZD
1 ST1TIS; 1DIPOSE TISSUE: BLOOD: BLOOD
1 PUSH; B100B SBBVB; IBTTBBOCTTZS;
I lIOKOCTtZS; HLK; OBI1B; BE»IE«;
I IIUTB HIZIIES: OCCOPITIOIIL BIMBOS;
1 PCPD11TIOI ZXPOSDIE: IIOPLlSBS;
1 PISTICIDIS; CRLOBI1E OBS11IC
1 CHPOOROS
1
1
50.8 og/kg I lactatlng sotbers
1
1 17-«1 yc olds froa Slavonia Province.
1 Jugoslavia.
1
1 TOGOSLlVIi: IICTITIOR: SILI;
1 EI01CCHBDUTIOB: BOBat 1BE1S;
1 CBIOIIHTID BIDBOC1BBO1S; CBLOBI1E
| OBGaBIC COBPCH10S; CBLOBOBI1ZE1IS:
I It I; DOT; BtllCBIOBQCTCLOHIIUE:
I EISTT.CIDSS
1
180 * or - 1*0 ppb | lilk bank donors
I
1 California
1
1 cuifOMii: UNITS: IRLK;
1 IIOlCcniBllTIOl; LlCTaTIOl; DDE; DDT;
1 PISTICIDZS
1
1
a) 50 + or - 38 ag/kg 1 i) Csla. large indastrialized city
b) «9 » or - 31 eg/kg | r) Bergen, large iadastrialized city
c) 39 » or - 17 ugykq 1 c) Barstad, saaller city vita large
d) 29 * or - 13 ng/kg I chenical/petrocaeiical complex
1 d) Porsgrvna, non-industrialized
1 fisting eonsanity
1 197* nrvey. Significant decrease at
1 all sanpling locations conpared to a
1 1*69/70 sarvay.
1 lotwgiaa anthers, ages 25-28 yc.
1
I ItlPOSZ TISSUE; IILK; COBPiSlTIVB
1 tvllolTIORS; K)B«1T: lOOLTS;
I IDTOPSISS; inBOBl; DDT: CB1CBII1TED
1 BTBEOCIBBOIS: DDT: PESTICIDES:
1 ECITCB108H1TID BIPBEITLS
1
flIXT PlGZ)
IEPB1E1CE

eichiann, V.B.
acDooald. I.E.
977
cotozicology and
Environmental Safety
:89-110




















Kodrie-Snit. B.
Slit, Z.
Olie. K.
1980
Pesticides Bonitoring
Journal 1«{1):1-2






narrod, J.E.
asgnith, B.T.
1980
lev England Journal of

303(16) :9«5-9*6

Brevik. E.B.
E-lerk, J.E.
1978
teta Pharmacologica et
Toxicologica
«3(1)s59-63












                                                                                                                                                                                              t-0
-------
Ittane, 1.1,1-trichloro-2,2-fcistp-cBlorapnenrl)- (8 CI)
Ecnxem, 1. tI-t2,2,2-trichloroethylid«i>e) fcistl-clOoro-  (9 d)

C11-B9-C15
IB 351.50. IE 108.5-109 C, BP 260 C, »P 1.5110(5-7) •• Hj at 20 C

tissos
3932
Ri Ik
3933
Silk, fat
1 393*
1 Placenta
f
1
3935
Dtine
»
UPOSHEI BOOT!
Ineestion
1
1

V -
inimcii
BET BOD
BC
OC-BC
1
i ec-Bc
1
» *
tmtSt
07 C*S
a) 21
b| 2«
C| «5
d) 15

a) 25
b) 15
C) 10

BUGS | SIl* 1 GEIIBJL IIFOBI1TIOI I KKBMCS
1 1 1
II 1
1 1 1
a) 0.045-33.122 ppa I a) *.223 ppi | »l faral lotters, fat basis | POIO Lora, H.
b} 0-10.361 ppi I b) 2.745 ppa | b) Orban aethers, fat basis I Berrera Racteache. 1.
•e) 0-13. 122 ppa 1 e) 3.««1 pp» | c| 111 letters, fat basis I Polo rillar, l.S.
fl) Tot gi»«B f S} 0.06S ppa I 4) 111 lotlieia, (hole ail* basil | Lopez-Gineaai, H.
t | Data for sei of all pesticides and | Jodral Tillarejo, B.
I | cciparismB «ith Talus of other | Iglealaa Perez. J.
1 I investigators qiven | 1979
1 1 I Fevista Ispaoola la
1 I Bursinii aethers fro* Cordoba region, I pediatria
I | Spain f 35(206) :93-1 10
1 1 1
I i spin; IDOLIS: aziK; cmoBiii osunc i
i i ccepooiDS: pEsnciots; IGBICHLTD»E: i
| | SIBIL IBUS; DBB1I 1BE15 |
t t i
a) Hot ot gifen | ppi | f) 1977, 20 saiplas I Hanita, If.
1 d) 0.1* » or - O.tS 1 | 1979
1 ppa | 100-1*1 lactating «oaan, 2 acaths | International archirea
1 e) 0.49 » or - 0.18 I aft*c dallrecr- lesideats of Osaka 1 of Occupational and
1 ppa | Ir*f«ct*re, Japan, varied diets aad 1 £B*lrona«atal Bealtb
1 C) 0.29 » or - 0.09 | e»iroa*eatal conditions. I 13:1-15
1 PPi 1 {
I i iisTicmts: SOT: OBGMIC CHLCBHE i
I | COIPOVIDS: JIM*: tDHlTS; UCTaHOI; |
I i (us; iioiccoauLtTio*: i
i i FciTcnoimiiD iipaariLS i
i i
lot detectable- 1 • ppb
Rot detectable-55 ppb
Rot detectable-210 ppb

1 1
at «. 1 » or - 3.9 ppb 1 a) Controls, fall-ten pregnancies i Sazeaa, g.c.
b) 19. S * or - 14.9 | t) Pre-tere pregnancies | slddiqni, H.H.J.
PPb 1 c) Spontaneous abortions at less than I Seth, T.D.
ct 57.2 « or - 71.8 | « »lt (iaelades fetss) | rtishna Sarti, C.S.
PPb | t Eharga»a, I.E.
1 BealtnT. non-ecposed, pregnant vonen, | KnttT> D.
1 age 1*-32 ji, India. ) I9B1
1 | Journal of inaljtical
| HDI1: 1BO»TIO»: iDBLTS; FlIOS; I TorlcologT 5:6-»
1 EICCD: Pticsni: COBPIBJTITE i
I iTitaiTions ; cnosiiaTis i
1 BltSOClSBOIS; CBLO8IR OfiGMIC I
1 CCSMHI3S: IISECTICIDBS; PISHCIDKS; 1
1 PISTICI3I SZS1BMS; POPtTHTIOf 1
t 'IPOSBRI; PI1GMKT |
....._ 1 1
) leviei | Delchiana, U.S.
1 I EaeDonald, 9.5.
I Ciposed perscus in the united states, I 1977
1 the Vetherlatds. Svedea. Israel, I Zcotoxicology aad
1 Japan, 7SS?, Poland, Gertany. India, 1 Zniitonaiental Safety
1 Eolgaria. Pakistan, Instrla. 1 1:89-110
1 1
I Beported cases of hrpertensicn. |
I elentel cer» cholesterol, abnorial |
I lC€s, or iapalraeDt of nearcaascalar 1
1 function after acate exposvce to |
1 coiblnatiois of pesticides, bat cost I
1 data show nc adverse effects after |
t lon^-teri occupational eiposnre. |
1 I
I nsni*: BDIGUII: GIEBUI; noit; i
| 15BIB1: JIPII; IRHE1LH1IS: PKISTtl; I
I ICIIDOT SDSSIl; SH5DII; DIII1D |
| S11TIS; 1DIPCSI IISSUS; B1OOE: B100D |
| PlaS<»; B10CS SUDHi SBTTBEOCTTBS; |
| ItOKOCTTJS; BIlKi B81IE; BBflHi |
I B1U1R IIZUIS: OCCVPtTIOIll HaZlSBS; |
\ IOI1HTTC1 EIPOS01I: IZOIlaSHS; |
| ftSTTCT«lS; CffLO»I*I OBOHTC \
\ CC1VOUIQS |
1 1
                                                                                                                                                                                        N3
                                                                                                                                                                                        c»
-------
It It**,  1,1.1-trlcfcl<>rQ-2.2,2-trlflaoro-
3f«-?8-S
cz-ci3-M
(f 187.38, Bf 1«.2 C, n »5.« C
TISSUE
3936
lr«ath










ElIOSOBB EOOI I












IBlimcAl
arm CD
ec/«s











IORBER
or cis is
8











EIBGS
lot detect «d-580.0 ng/hr
"










mi
88.3 «g/hr











GEItlAI. IirOBBATIO*
Pntiois eiposare to conponad. lo
ether details gives
Cryogenic saiplinq technique.

lealthv lilitacy ana civilian
employees, O.S. air lore* School of
Aerospace BediciM. ages 23-»7 yr. 3
iiokers.
tllZEBES: CBtORMATII BYDBOCABBOHS;
cnoBii? otcinc coieonos;
CBioBomznis: twonn COBPOOIBS:
tsuiH: iiccBots; TE»S: iiniis
BEfSIEBCE
Conkle, J.P.
Caip. B.J.
Mich, B.I.
1»T5
lICklTQB Of
Imlronaental Bealth
30(21:290-295





IthtM, 1.2-dichloro-
107-06-2
C2-B1-C12
(I 98.98. BP -35.36 C. BP 83.5 C. TP  100  ••  Ho.  at  29.4 C
IISSO!
3937
Ircath










IIPOSQtS SOUI1 |
1
1












1ULTTICU.
BRBOD
6C/BS











KDBBIB
or cists
8











ItlGB
Bot 4at«ct«d-0. SO ng/hr











Bill
0.10 ag/kc











SEItitl IBfOBBHIOB
Coipomi froi ankaovB origin. lo
ctfc«r details qiven
Crroqenle saiplinq techaiqae.

Bealthr lilitacr and civilian
eiplorees, V.S. lir force School of
lerospaec Dcdieliie, ages 23-07 jr. '3
linkers.
EtKtRSS; CBIOBIIITZE BTDBOCABBOHS ;
cnosm oBsinc COBPOVIDS;
CB1QBO!BB7IIIS; FID C8 I IB COBEOUBDS;
MllIH; HCOBOtS; THIS; »BOITS
BE rial JOB
Conkle, J.P.
Caap, B.J.
Belch, B.I.
1975
archives of
EnTiroBMntal Health
30(2);290-295





                                                                                                                                                                                             K)
                                                                                                                                                                                             VO
 Ithanol. 2.2,2-trichloro-
 115-20-9
 C5-B3-C13-0
 ft 1»9.«2, BI 18 C, B? 151-153  C
•ussot
3938
Blood


EIPOSOB! SO01E
Inhalation
•

UUCTTCll
RETBOD
GC


BDHEEB
or CASES
5
-

S1IGZ |
1
_,
a) 0-2.8 ng/al
b) 0-1.* ug/»l
- 	 - -
(HE IT
9E1B 1
a) Bot given
b) Rot given

PJGI)
6ZBCB11 I1FOSBITIOI
a) 10 hr and day 5 of SO ppi
tcichlocoethvlene, 6 hr/daj, on 5
conaecative days
t) 10 hr and day S of SO
tcichloroethvlene, 6 hr/day on 5
consecative dars plas ethanol
pcetceatcent. Ethanol given to
•aintain blood level of 0.06*.
20-26 vr old students. »t 62-77 kg.
CBIOSIBJTID BTB8OC»BBO!IS; 1LCOHOUC
ItVntASES; BIOOD; BLOOD PL1SB1;
OIIIE; HETIB01ITES: DEMBOIISJI:
1 CULTS; GTIBAtT

EEfEBSBCE
Buller, G.
Spassonski, B.
Benschler, D.
1»75
Archives of Toxicology
33:173-18»
1

-------
     Itbanol,  2,2,2-trlcUoro-
     11S-20-8
     CS-B3-C13-O
     ft 149.12, » It C. EP 151-153 C
                                                                                           (COITUOED)
IISSOI
3935
Urine















Eivosns BOOM
Inhalation
















1U1TTICH.
BETH CD
6C
















IOEBSB
OF C1S3B
S
















B1ISE
a) 160-35 19
i) 120-10 •?















mi
a) lot giren a) Rat
9iren















Giimi iiroifliTios
a) Day 5 and 6 of SO ppa
tricliloroetfcTlsne. 6 hi/day, 5
consecutive days. Initial value. 102
•9 *n day 1
ttieiloreetnyleita. 6 ar/day, 5
ccase«ti*« taya plas ethaiol
Tt«tr«ata«nt. Initial valv«, 70 ug on
ttl 1
2* ar etcretloas. Itaaaol glren to
•ajatalt blocd !«»«! of 0.0«%.
latiaatea fcoa grapi.
JO-26 yt 014 stqdoata, lit «J-77 kg.
CELORX1HED HIOROCIBBOSS: 1LCOBOLIC
I1T1»»SIS; IIOOD: BLOOD PLlSOi;
mil; arriBOLiTES; HBTISOLISH;
i coirs : sEtauy
i
ssnetici
Bailee. 6.
Spassovski, B.
B«nschl*rr D.
197S
Jlrcbives of To xl colour
33:173-18»












   Rtciw. dicalorodlfloaro-
   i71«-03-2
   «« 133
TISSUE

3940
Br«ath







1
1

i
1 ElfOSOBB BOgiB














1 1IURJC1L
I BETIOO
1

GC/IS












VDflBSS
or cisss

8

f










I B1IGE
1
f
lot tat«cted-0.029 og/ir











'
BE19

0.009 ag/lr












t GEIIiil IKFOIRaTIOI

FreTioos czpasnre to coipoimd. Ho
cttor datailc qi»«n
Ciyogeaic saapliag technigae.

acalthy ailitary aad ci»ili«o
•aploye«sr 1?.S. lir FOTC« School of
lerospace Hedicin«v ages 23-47 yc. 3
saokecs.
CIIZEVIS; CHlCSHlTtt BTOIOClBBOlS;
CKOBTKB oseinc coipotmos;
catCHoetmns: PLHORISE COIPOETIDS;
fBHTB; 1ICOBOLS; TlliS; iBOlTS
1
BEPE1EIC!

Conkle, J.P.
Caap» B.J«
»elch, 3.1.
1975
ArcbiTM of
EavironBental Health
30(21:290-295






                                                                                                                                                                                               CO
                                                                                                                                                                                               o
Itljl aleohcl  (8  CI)
Itaanol  (9 CI]

C2-B6-0
It 16.07. U -117.3 C, BP 78.32 C,  tp HO an Bg at 19 C
IISSOI
39*1
Blood








t
EIPOSIBS BOOTI
Inhalation










IIIITTICII
iZTICB
GC










•OJIBIH
OF CISSS
6









1
BIIG3
a) 0. 039-0. 06«
b) 0.0»3-0. 073S









9X11
a) 0.0541
bl 0.059^









GEitui irroasiTicu
..
a) la trichlcioethylene treatieit
b) 100 ppa trichlorOBthyleoe
Sange amd icaa for 6 \t period

20-26 yc old students, vt 62-77 kg.

CILOEIlkTID BIDBOCIBBOSS; AlCOHOLIC
HflBlSIS; BIOOD; BICOO PllSSl:
DBIBEl II'TJBCIITES; 15T»BOIISn;
icnirs; GIB tin

IBFEBZICE
Bailee, G.
Spassovski, R.
Peosciler, D.
19.75
iTcbiTes of Toxicology
33:173-189





                                                                                        (1111  PaSl)
-------
      alcohol  (8 CI)
ttiaaol  (» CI)
CJ-B6-O
» ««. 07, BP -117.3 C, BP 78.32 C.  TF «fl •• tg at 1) C
ttSSVt

3M2
Breath




3M3
Heath










39M
Breath












nposm SO«M

































1I1XRIC1I
BET BOB
ec/as





SC/IS











SC-15













BffBEJB
or cisxs






6











5* (38T
saeples)












I1IGX

0.05-0.36 ppe





lot oetected-MO.O «g/ar











lot ai»«













nil

0.13 ppa





136.1 no/he











9.* ««/!
GCOMtClC












eiHui nrosniTioi

Corrected for level is inhaled air

tcaltir adllt*

sunn: HQHS: BHSITEIBT«I IRBOVS;
fiinioL
Coipani rtlatei to normal
eetahollai. lo otter details girea
Crrogenic Baiplla? technlqve.

Bealtkr "Hilary u« elTlliaa
caployees, U.S. ail force School of
Krespace s«dieia«, aqea 23-*T Tr. 3
giotori.
iiizms; cnoBimit ITDBOCHBOIS :
CBIOUMI oistric CPHPOTIIDS:
cnioBomznzs: n.0otm COBPOOIDS;
isiiTS: iicoiois: tnas; IDOLTS
Kanrei at 25 C aid 760 >a B?
-------
  Ithyleae (8 CI)
  Itnene (9 CI)
  74-85-1
  C5-B4
  HI  28.05 C. IP -169.» C.  BP -103.9 C. TP 100 •• Bg at  131.8  C
TISSOB
3946
Breath










EIPOSDSS BOOT!












ininiciL
BSTBOD
GC/BS











BOB BIS
or CISBS
8











BMGB
let detected- 120.0 ng/hr











BZ1B
1S.1 «g/hr











GEIZUL IIFOR81TIOI
Ccsponad related to noraal
Htabollsi. le other details given
Cryogenic sampling teehnigie.

lealthy illitarr aid ciriliaa
employees, O.S. lir force School of
lerospace Bedieiae, ages 23-47 jr. 3
ciokets.
tiixnts ; CBIOBIBHBD ITOBOCISBOVS;
CBIOBIK OBGIHC coiPooiDS:
CBioaoBE«u»is: FIOOBUE COBFOOIDS:
iiiiTB; iiccEois: TBIIS; IDOITS
BErXBEICB
Conkle, J.P.
Ca»p, B.J.
Velek, B.B.
1975
•rchires of
BoTiroBMatal Health
30 (2): 290-295





fthylene, chloro-  (8 CI)
!th««, ebloro-  (9 CI)
7J-01-*
C2-B3-C1
BB 62.50,  BP -13.« C, TP 2600 •• at 25 C
I IISSOS
1
1
1
1 39»7
Breatk





XtPOSDBB BOOTI I 1ULTTIC1L BDHBS
I BBTBCD OP C1SIS
1
1
Inkalation 1 GC 5
t
1


1
1
IIB6B



a) lot giren
h) Bot gl«n
c) Bot givea
d) Bot gi»«»
e) Bot giT«n
f) Bot given

1
1
1
1
1 1
1
I 3948
1 Ereath










1
1
1 6C/ES

\























g












ug/kr










IStl



a) 27.6 eg/en •
b) 11.2 »g/cu a
c) 5. 8 ag/cu e
d( 2. 8» «g/co a
e) 1.30 •g/Cd a
f) 0. 5» ag/ca a







0.09 tigXhr











GBIZB11 I»FO»»»TIOI



a) IieeJlatcly after $0.0 ig/co •
fc) leieaiately after 30.0 ag/ca •
e) lemediately after 15.0 ag/ca •
1) 30 lin after 60.0 ag/ce e
e) 30 ala after 30.0 ag/cn e
f) 30 iln after 15.0 ag/ca •
6 hr ezposare

Bealthr 26-31 ji olds, Poland.

fCllBD; 1D01TS; BB51TH; TIITI
CCBPOOMDS: lIBllaTIOl


ether detail: glTea
Crrogenlc saipllag technique.

Bealthr allltarT and cirillan
eeployees, O.S. »lr Force School of
lerospace Kcdiciae, ages 23-47 yr. 3
eiokers.
IIBIZVIS; CBIOBIIHTIt BTDBOC1BBOBS:
CEIOBIB« OFGICIC COIPOVVDS;
CB10BOBB1ZZIIS; FLUOBIIE COBPODlDS;
EDIITR; HCOB01S; TZXtS; IDOITS
BErZIBBCZ



Itralenski. J.
Oobeckl, B.
Groaiec, J.
1980
British Journal of
Industrial Bedicine
37:373-374







ConJcle* J*P.
Caap, B.J.
Welch, B.B.
1975
IrchtTes of
Environaental Health
30 (2)! 290-295





                                                                                                                                                                                             CO
                                                                                                                                                                                             NJ
-------
      e-m. cUorofJaoro- (S CJI
         cMeroflsoro-  (9 CI)
   m.*«
TIJSBB
W»9
Eceatk










UFOSIIS MOTE












auirticiz
BRTHOD
SC/HS











units
or cisxs
-
a











11*61
lot detexrted-a. 5« uoybr











mi
0.07 ng/br










..
6EIEML IIFOIBUIOI
C«ipomi ftoi uk>an origin, to
other details qln*
CXTogeaic saapliag technique.

icalthr lilituy and civilian
tiploTees, U.S. lit Force School of
lerospace ledicise. ages 23-H7 jr. 3
ssokers.
{IllntS: CgUMXIHEO BTDIOCUBORS:
CdOBin O8G1HC COIIOniDS;
caiOBOinzms: TUJCEIH COHEOBHDS;
I«1HB: HCOEOtSj THIS; 1I101TS
	
0E^£BEVCE
Conkle. J.P.
Cup. B.J.
Mick, B.E.
1975
lrctiT«s of
iBTirouental Maltk
30(2):2«-295





          tctcuckloro-  (8 CI)
Eth«M, tctcachloro-  (9 CI)
1IT-H-I
ea-ci«
II ISS.85. It 121 C
1ISSOI



3950
Blood







3951
Brain









3952
Breath













1IMSVEB BOOH | IHITtlCtt



Inhalation








Inhalation










Inhalation













HETBOD


8C-IC








GO-EC










OC













WttSBS | BUCK | BE1I | 6E1IU1 HF08BIIIOI
OF C1SES | | |
1
I
1








1










a) 29
b) «2
-------
 tbyleae. tetrackloco- (8 CI)
Etteae. t«tctchloro- (» CI)
C2-CM
It 1«S.«, » 121 C

1ISSO
3*53
tteatk
3*5*
Bceatk
3»55
3956
39S7
»
xuosviE to


nkalation
•talatlon
kaUtloa
1U1TTIC11
HBTBOI)
GC/iS
OC-9S
8C-BC
ec-sc
EC
B1MBXB
OF CUE

M (387
uiplos)



HUBS
lot detect«d-2. 0 ag/hr
tot 9! ren
ot applicable
ot applicable
applicable
BEil | GBIIMI ZirOIMIIOI | BEfEtEICE
1 1
1 1
1 1
0.3 ag/kr | Ftcvloa* eipcnre to compotmS. la t Cockle, J.P.
1 clker details give* I Ca*p, B.4.
I Cryogenic saaplUg technique, i lelek. B.E.
1 1 H75
1 Bealthr ailitary ud civilian | ircklres of
I eiplorees. U.S. Air force School of t Environmental He a It k
1 aerospace ledlciM, ages 23-17 jr. 3 1 30 (2) :2»0-295
1 stolen. |
1 1
1 ftnntSt CHOSIHTED BTPBCC1B30HS; |
1 cnoiiBS oBsirtc COBPOOIDS: i
| CIlOIOEMZHtS; FLDOBIII COBPODIDS; I
1 iiiHi: itccBois: THIS; unts i
i i
< i
2.6 ng/1 | teasared at !5 C aid 760 •• Bg | trataszfBslEi, B.C.
Seoeetric I 30.2V occurrence f Braneaa, e.g.
I I8«er ••< «ppsr on«-Sig»t Halts 0.51 I O'leill, B.3.
1 aa4 13.2 ag/l | 1»7«
1 I JoaruL of analytical
1 Beeltkr. 18-35 TC old. nonaaotinq. I toxicology 3:225-23*
1 oi tan blacks and cancusflaas. I
( CUcago, It. tWiJlr-contrellea I
I experimental conditions. |
1 1
I IBHTH; atCCBOLS; IILtfOIS; 1DDLTS; I
| CBlOKiriTEB irDBOCJBBOMS; rOUTHI |
( cxeavic COBPCOMS; SEU.TH sir IB us; i
| IBRlUTICl; BBTalOLISS; BZTaBOlIIES; I
| EOPDUTIOB IIPOSOtE; OBB1I 1BI1S 1
1 f
1.0 eg/kg I Utopjy, 2* kr after deatk, dose I Lev lire. B.
1 indetemiBed. | rlerro. B.F.
1 1 Coze, S.».
1 53 rr old, 70 kg, dry cleaner, tt. ( Talaatoor. I.e.
1 1 1991
1 VltSIIU; 1D01TS; iOTOPSIES: BIOOD: | Journal ot Forensic
I fB»r«; 5IOIITS: LITBB; LUB6S; | Sciences 26{1) :206-20«
1 fcinstc BtcicisE; CBIOEIBITED i
1 *T9(oc»sBcrs: iiroasmu iccioevrs; t
1 OCCVPITIOMt MZ1BDS; UDDSTBUL \
t CBE'ICILS |
1 {
0.0 sg/kg 1 lutopsy, 2* kr after death, dose I Lirine, B.
I gnl«tenl>ed. | Plerro, B.f.
1 1 Goza, s.v.
1 53 yr old. 70 kg, dry cleaner, n. 1 falentoar. J.c.
1 I U51
1 incznt; IBOirs: inofsitsi BLOOS; i joaroal ot Tor en sic
1 ItHV; SItltTS; IITE8; 10I6S; | Sciences 26(11:206-20*
| 'CBMSIC lltlCIB!; CBLOBUWID |
| EIDBOCUBCIS; HDJSTBIU 1CCIDEETS: 1
1 OCCVMTrolIt niHBS; ITOHSTtHL |
1 CBJnrciLs |
1 1
1 1
.0 ag/kg t litopsy. 2* kr after death, dose ( t«ilee, B.
1 nd«ter«ined. | rlerro, H.r.
1 1 Got*. S.I.
1 f3 TT on. 70 kg. dry cleaner, Tl. I T»l«ntoor, J.c.
1 1 »«1
1 iiisiin: >iat,TS: IOTOPSIIS: BLOCK: t joernal of forensic
1 EB»I»; tcnniS; IITEI: must I Sciences 26 (1) : 2 06-20*
| fCBZISIC 
-------
 BttvleM,  tetracMoro-  (8  CIJ
 ctaeae, tetncfcloro-  (9 CJ>
 IZ7-M-I
C2-CH
SI 165.85.  BP 121 C
                                                                                      (CORIKIED!
T.ISSBE
3SS8
Briw











EXfOStTBX BOOT!
Inhalation












1ULTTIC1L
BZWOD
Caloriietrr












rorasE
Of C1SBS
2












SWGE
» 1-7. a 19/1
b) 0.3-5 a«/l











BE1B
a) lot given
b) lot given











GEIEBll IIFOIBITIOR
a) Start of exposure to peak at 10
he. 2.3 aq/1 at 22 hr
i) start of exposure to peak at 12-20
ht. (.3 sq/l at 25 nr
]c triehloroacetie acid after
eiposure to tetracbloraethvlene
vtpors (390 ao/1) orer 6 hr «iti t»o
30-aln brcats. sliainatioa only a
fc« percent of dose. ZstiaateA froa
graphs.
fclntMti
TC11I9; UBIIE: lETtBOLISB;
CELOBIIITIC ETDBOC1BBOIS
er re MICE
Bolanovslca, V.
Golacka, J.
1»72
Belrcyna Pracr
2C23):109-119;
TC-78-0130







     eae, trlckloro-  (« CI)
Itkaae, trickloro-  (9 CD
19-ai-6
C2-B-C13
g?  131.«».  gc 73 C,  B» 87.1  C,  It 100 n 8g at 32 C
USSHE


3959
Blood












3960
atetth











EIWSUBE SOOTI


Inhalation













Inhalation











1I11ITICK
HITHOD

GC













ac











BTFiBES
OF C15SS

«













<











sue:


a) 0-2.6 09/al
1) 0-1.3 119/mi












aj 0-38 pp.
b) 0-11 ppa











n&i


a) lot givea
b) lot given












a) lot gliren
b| Bot ?i»en











611 HiL IIFOtBJTIOl


a) 0 aad E hi after start of 100 ppa
for 6 hr. Final valve, 0.2 uq/»l at
2« hr
b> 0 and » hr after start of 100 ppi
foe C hr plis etaanol pretreataent.
final Talae, 0.1  at 21
bl
t) 0 aid 5 hr start of 109 ffn for <
«t pins ethanol pretreataent. Final
valve. < 1 ppa at 2* hr. Ethuol
qiven to naintaia blool level of
0.06«. Bstinated fros graph.
20-2« rr old stadents, *t 62-77 kg.
(ElCBIIIlTED EIDBOCiSBOlS; ilCOHOLIC
»T1B1«ES: S100D; 910QD PUSH;
T15I1F: BCT1BCLITES; IP!T»BO1ISH;
ItTLTS; GESillY
BEFEBEIC! f
j
1
laller. 6.
Spassonski, B.
Benschlor. 0.
197S
irchives of ToiicoLogy
33:173-189








Holler, C.
Snassottaki. 8.
Censchler, 9.
1975
archives of Toxicology
33:173-189







                                                                                                                                                                                             OJ
                                                                                                                                                                                             Ln
                                                                                        (HIT PIS!)
-------
fthvleae, trichloro- (8 CI)
ttkeae. tclcUoco- J9 CI)
7t-01-«
CS-B-C13
S« 131.40, SP 73 C. BP ST.1 C, TP 100  u  «g  at  32 c
                                                                                      (COITIIUBD)
I 11SSOJ
3M1
Ireath
3962
Breath
3»«3
Ortse
ZIPOSOBI 100


halation
etWl
IIILTTICU
SBTBOD
IX
9C
OC/BS
SC/BS
IIBBIB
or CISE
4
a
0
tuet
a] sot given
b| (at given
c] tot given
d| lot gi««
a) (at given
fl lot given
»ot feteeted-3.9 ngyhr
•-22 «j/l
BE*« | CI1IBIL IlTOtStTIOI I JEWHMCB
1 1
1 1
1 1
a) 28.7 ppa | a) 1 ill after 200 ppa, 7.5 hr 1 stevirt, C.D.
b) 58.3 pp» | t) 1 «ti after 200 pps, 7. 5 hr, plus I Bake, C.L.
c) 14.2 pp« j ctbaaol { Peterson, J.s.
d) 29.3 pp» | c) 30 tin atter 200 ppi, 7.S kc I 1974
e> 9.9 pp« | a) 30 ili after 200 pp«, 7.S hr. plus ( trciirei of
aol |
I Ithaool doac, 1 qt beer or 90 •! 1
1 *o4fca after 5.5 hr of TCE 1
1 1
1 BealthT 19-»6 rr olds f
1 1
I Tasodilatatioe. of saoerficial resaels 1
j <* face, cheat, shoalders, tetveea 1
1 xca^olae, peaking at about 30 iln, 1
I »«dinq \>j *0 iln. Lesions not I
j accaapaaied tT subjective response, 1
I at changes in blood pressure, 9K0, t
1 etc, iriaalTEts, 501-12 panel. I
t t
1 ICIIIS; DZlRHITIS: 9IUTB: DBH« (
1 inmciioi; ticoHoxs; ceioeifs i
I cioisic comcoivs; BIILTB BIZISDS i
i i
1 1
0.54 vg/hr I Fievioas expoamre to cosponid. iro 1 Cookie, J.P.
1 ether detail* qivea ( Caip, B.J.
1 Cryogenic saapliig techaiqne. 1 Belch, B. B.
1 1 1»7S
1 acalthr nilitarT and ciTilian 1 Ircaive* of
1 eiploreea, V.S. lie Force School of 1 Enrironaeutal Health
1 lerospace ledlctne, ages 23-47 rr. 3 1 30 (2) : 290-21 S
1 siokers. I
1 1
1 CEIZniSi C8IOEIIITZD HTO«OC»BOHS; 1
1 CEIOBHE OBSinC C08MOTDS; I
I CEicsoBimms: nvostiE coapoorns: i
1 IBI1TI: ItCOgOLS; TIT IS; «D01TS I
1 1
1 1
0 • or - 5.9 ig/1 | it trlehlocoethanol (Mtabolite) 1 Perdelllai, t.
1 Data also on solvents In factory air 1 Bragnoae, T.
1 t Pavan. T.
1 letters In shoe fact or T in Italy i »*«0
1 I Toxicology and Ipplied
1 DIIIB: 8TDBOC1BBOIS; IPTIBOLITES: | PSaraacOlogf 53:220-229
I nttT; HDismii inosptrzoss; i
1 HtUSTSIlt ITSICfE; US PO[tUTIO»: |
1 CCCOP1TTOIII OISEtSES {
1 I
                                                                                                                                                                                           U)
-------
 FthFlew,  t,1-dlcUoro-  (8 CD
 I«k«M,  M-dichloro- 19 CI)
 TS-3S-*
C2-M-C12
II «fi.9«, » -122.1 C,  BP 37 C, TP 100 •• B» at 15 C
JISSOI
39«»
Breath










EXPOS*!* IOSTE












tiaimcu
nTBOO
«vas











IOIBES
OF C1SK
8











sues
»ot detected-13.0 ao/kr











mi
1.6 ag/hr











esiuii IIFOBHMIOB
Previous eiposare to compound, lo
ether ietailc aiven
Cryoanic saiplin? technique.

lealthr "Hilary ud civilian
employees. U.S. ale Farce School of
lacespacc Xilicina, aq«s 23-4T jr. 3
scoters.
EIRZISS; CHLOBU1TEC BTBEOC»EBO»S:
CHLOBII1 OI6UIC COKPOnilDS;
cBio?oBEii!«is: nnoBi» coiponns;
EB!»TB: I1COBOLS: TCT15; IDDITS
UFEIZICE
Conkle. J.P.
Caip, B.J.
Velck, B.E.
1975
KrchlTcs of
EaTiron«ental Health
30{2):290-MS





ItkyleM, l,1-«lcliloto-2,2-bis(p-cliloropbeiijl)-  (8 CI)
ECIMM, 1,1*-(dlekloroetlM«illteM)bls|a-ckloro-  (9 CI)
12-55-9
CK-S8-CH
B« 318.02, K 88.• C
IISSTJE



39«S
lAipose
























39(6
liipoae









BIKJSUBB «OHT1








































IIIITTICIL
8 IT BOD




























GC










*
-------
Itajlane.  1.t-aicUoro-2.2-bis(p-caloronhearl)-  (« d)
MBxeae.  1.1*-(aicaloroetaeB)li4e»«)bis(*-caloro-  (9 CI)
7J-55-9
81 318.02.  IE 88. « C
1ISSI
3967
idipos
3968
laaioti
fluid
3969
Blood
1
3970
Blood
EXfoson loot




B liUYTICaL
BETBOD

ae-BC

X-K
(OSBEB
OF CaSSS
•> 27
*) 1
Cl 1
SO

25
IS
10
iaiG>
•) lot giTea
b) lot giten
c) lot alien
2-21 ppb

•-32 ppb
13-281 fpb
32-325 cpb
Mil | SZIZB1L IIFOBBaTIOl I BEPBBSIC1
I 1
I 1
I 1
a) 11.9 » or - 9.70 | •) Bospital patients 1 Inon. T.
ppi | b) 13 yr old feaale rfth Yusho | Ibe, 3.
b) 1.C ppa, f«t basis I el •« jr old aale »ith chronic PCS { Takaaatsv, H.
O 1. 5 ppa, fat basis | fot»nl«<} I loki, I.
1 i Him. s.
1 Japan 1 Fajiwara, K.
1 1 1975
I fClTcnORIMin BlPenitS; DDT: 1 rafcooka Sedical Joarna
| lIHCnOBOCTCIOIIMKEi BLOOD PlISBli 1 66(10:610-616
| lEOniSRS; JIF1I; GlSTBOinSSTIUL I
| SISTI8; PESTICI9ES; IDIPOSf USS0E; 1
I IITZg; KIDIBIS: OBEITVR 1
1 1
10.51 ppb f ao poaitirc apociaaas 1 Sazeaar B.C.
Seoaetric I I S*th, T.D.
1 Itegaaat towa, aiailic IB ' 1 Bahajan. P.I.
I sociovcoaoaic ler«l and diatary 1 1910
1 tabits. Ho occopatioaal or I International Journal
1 accid«»tal exDosare. I»c!cno», India 1 of EnTicoaaental
1 1 inalitical Cbeaistry
I EISTICIDIS; CRIOiniTSD HTDBOC«BBO»S; | 7:2*5-251
1 ciionis oieinc COBPOOIOS; ODD: DDE; i
I tCT; I«OI»; FBESIHCT; 1BIIOTIC 1
1 HOIS; P11CIIT1 1
I 1
1 1
I ICTle* I Deictaann, I.B.
1 | RacDonali, ».E.
I iipoael perscas in th« United states, 1 1977
1 tne Watkeclaads, S*ctea( larwl, 1 Ecotoricology and
j Japan, USSB, Poland, Garaany, India, j Earironaental Safety
I Bolqaria, PakistaB, lastria. | 1:19-110
1 1
1 Mpoctel cases of hypertension, 1
I elentei seraa cholesterol, abnoraal |
( IZGs* or iapairaent of nearoaascolar I
I function after acate exposere to 1
I coabinations of pesticides, bat aost j
1 data shoe nc adverse effects after j
1 Icng-tere occopational exposure. 1
1 1
1 iisr»i»: raiGtKii: GIRBIIT; HTDI»: i
r issin; J»P»I: (XTBESLUDS; PIKISTH: i
I ICIIID: sDssii: s«E9ii; DIITED i
I suns: IDIPCSS TISSUE: BLOOI; BLOOD i
1 EltSU; B1CCD SSIOB; SHT180CITES: I
1 itoirocTTES: mi; nsiit: stntt; i
1 BtltTfl B1Z1BCS: OCCnPITIOBIL BaZtSOS; |
1 PCPBHTIO« ZIPOSOBE: IFOPllSBS; I
1 PISTICIDIS; CBLOSIBE OBS1IIC |
1 CCBPODVDS I
1 1
1 1
12.6 * or - 70 ppb 1 a) Coatrols, fall-ten pregnancies t Sanaa, B.C.
57.8 * or - 65.3 I t) Pre-ten cre^aaacias I Siddlgai, B.K.J.
pb j c) Spontaneous abortions at less than j Seta, T.D.
163.8 » or - 105.2 1 t w* I Krishna Horti, C.5.
b | 1 Bhargara, i.K.
I Bcalthy, non-«xpO9ed, pregnant voaen, 1 Ratty, 0.
1 age 18-32 yr, India. I 19t1
1 | Journal of analytical
1 11911; aBOBTIOf; IDOLTS; TITUS; | Toxicology 5:6-9
I tlOCD; PtlCXRl; COBP1B1TITE I
| ITltniTIOBS; CHLOBIHTED |
| BIDBOC1BBOBS; CBIOBIR OBGIBTC 1
| CCBPOtJUDS; IISBCTICIDIS; PISTICIDSS; I
| PISTICIOI BESIOOIS; POtHLlTIOll |
| tlPOSnii PBICBaBCT |
1 1
                                                                                                                                                                                       u>
                                                                                                                                                                                       CO
                                                                                 (Bill »aSZ)
-------
 ItkrlM*. 1.1-aickloro-2.2-M«fp-cklOTO«n«Bjrll- (8 cq
 BCIMM, 1,1<-(dieklorostlMnjlla«M)bls(*-eUoro- (* CI)
 72-S5-9
C14-18-Cl*
 I* 318.02.  n 88.« C
                                                                                     (COITIIOID)
tISSBB



»71
tood.
Lasu













3172
Blood,
plasna















3973
Blooi,
sens



















397%
Kidney









MOSBBB com






































































IB11YTIC1L I B9BBES
•RIOD I OF C1SIS
1
1
1 *) 27
1 b) 17
1 0 37
> d) 1
1 •) 1
1
1
1
1
I
1
1
1
1
•
1
SC |a) 139
1 b> 175
1 C> 199
1 4) 210
|
1
1
1
1
I
1
1
1
1
1
1
1
1
OC | a) 41
1 b) 19
1 c» 50
1 *) 28
1
1
1
1
1
1
1
|
|
1
1
1
1
1
1
1
1
1
1 1
1
1
1
1
1
|
1
1
1
1
UKI



lot five*
lot elves
lot «!*<•
lot aim
lot «.l»ea











) 0.8-43.5 ppb
b) 0.1-18.5 ppb
c) 0.5-7.* ppb
d) 0.3-9.7 ppb














a) 1.2-31 uo/1
b) 9.2-118 «9/l
e) 7.1-213 nq/1
d) *.i-« uoyl


















lot applicable










HI! | 611(111, IMOBB1TIOI | IBFE1EICI
1 1
1 1
1 1
) 29.1 » or - 10.51 I a) Hospital patients | Inou. T.
ppb I b) Euclated person* I Ibe, S.
) 35.6 « or - 22.65 I c) •on-esaciated' persons 1 Takasatsn. B.
pb 1 o) 13 yr old tesale with Tasho < lokl. 1.
1 21.9 * or - 15.95 1 •) 2* yr old aala wltk aplnstic 1 Biki. S.
pb I aiesie a«d atoaach eaacer I fajlvara, X.
1 13 ppb | | 1975
1 180 ppb | Japao 1 rvkaoka Bcdlcal Journal
1 I 6«(10:610-«16
1 FOITCHLOBIUTP) EIPBIITLS; BET: I
I BIHCBtOBOCTCtOBniBB; BLOOD PL»SS1: I
1 BIOEL1SIS; JIP1I; 6tSXBOIITBSTIIU. 1
1 SISTBB; fBSTICIOBS; IDIPOSB IISSO!: I
1 1ITII: 5IDIITS; OBEBTIII 1
1 1
1 1
a) 10.5 ppb | a) Bural blacks 1 Fiaklaa, J.
b) 6.2 ppb | b» Urban blacks 1 Priastar, L.E.
O 2.5 ppb | e) Ocbaa cancaslaas I Creason, J.P.
4) 3.« ppb | 4) Ural Caucasians 1 Bauer, T.
1 1 Blnaera, T.
1 urban aal taral residents of SC, [ Bauer, D.I.
1 Infants, cklldcen, adnlts, eUerly. | 1972
1 j taerlean Journal of
1 SOOTH CUOIII1; 1DD1TS; CB1UHII; | Public Health
I HCIil STODTBSi BLOOD PLaSHl; | 62(5) : 6*5-651
I CCHMKITI IttLTJITIOSS; ODD; IBE; |
1 ICT; BIB1DHIB; PESTICIDES; (
I ECITCBLOIIIITID BIPHCTTIS; *IP 1
I toiwreioi; rcoD commtnoi; i
1 PtSTICIDt ilSIBOES; VO?ITUTXOB |
1 IIPOSVtB; SOilL MtBlS; HKBII UttlS |
1 1
1 |
a) 6.9 a VI 1 a) General population - continental I Kranthacfcac, B.
b) 29 u/1 | central (ratal) 1 klebic-Kolbah, T.
c) 53 af/1 | t) Ceeeral popnlatioa - continental | Kralj, a.
d) 23 a«/l | foatk (urban) | TkalceTlc. 3.
Oeoaetric neans | c) Szposed (erkers - contiaaatal I Beinec, S.
1 aorth («rbu) ' | 1910
1 9) Exposed vcrkecs - contlaental \ International irchires
1 tootk (arban) | of Occupational anl
1 1 ZnTironnental Healtk
1 General population, aqea 6-79 yr. I «5:217-220
1 OccipationnllT exposed vorkecs. ages t
1 20-62 TC. IllMlaTla. I
1 I
1 TBtOSUTIl; BLOOD SEBOII; CBLOBII1TSD I
1 BTDBOCIIBOBS; CBLOBIB! OBSUIC |
1 CO»POO»DS: CtC; DBS; DOT; |
1 IHlCBLOBOCTCLOBETalE; PISTICIOES; I
1 CCCOP1TIOI1L HITIRDS-. PESTICIDE |
1 IZSIDOES; POfOliTIOI BXfOSBBI; B1B.1 I
1 IBIHi U8B1I MI1S |
-_..(• |
1 |
76 ppa (fat basis) 1 2* JT aid ul* ulth aplutic aienia I Inooa. I.
1 ail stauck cancer t »b«, s.
1 1 Takauatsu, a.
1 Japan 1 Joki, B.
1 t Hikl, S.
1 FCITCHLOBHIT1D BIPBHTLS; DOT; I luliwara, E.
1 BHlCSIOSOCTClOBnill: BLOOD PLISI1; I 1975
1 IIOfLtSIS; JIPII; GtSTBOIBTISTIIlL 1 fukaoka fledical Journal
1 STSTCT; PISTICIOES; IDIPOSE IIS SITS; | 66(10:610-616
1 1ITIB; KIDIHS: omTOR |
1 1
(HIT P1GI)
                                                                                                                                                                                          U)
-------
          1,1-aicsloro-2.2-bis(p-chlorojhenTll-  (6 CI)
Eenzene, 1,1'-(illcklocoetlieailidena)bis(«-ckloro-  (« CI)

C1«-B8-C1«
CI 318.02, II 88.» C
ttSSB
3915
I tier
3»7«
Bilk
3»T7
Bilk
1
1
I
397J
tin
39T«
Bilk
sirosoBB 10




estion
~ i
IRUYTICll
BBTHOD

SC-EC
SC/BS
-


•agora
or cis
1
10
25

21
2*
45
«S
1M6Z
lot applicable
•2.0-H18.5 «g/kg
(at glT««

0.935-2«.«06 pp.
0.535-13.407 pp.
0. 535-26. »0« pp.
lot given
BMf | 61BIU1 XBF01UTIOB 1 MMBBfCE
1 1
1 1
1 1
ISO ppa (fat basis) I 2* TT old Bale slta aplastlc aseaia 1 mom, I.
j aid stanch cancer | *be, s.
1 1 lakaaatsa, 9.
1 Japan | »oki, ».
1 1 Bikl. S.
1 soiiciuniiiTtD BiPBims: DBTJ i rnll«ara, n.
I nntcBioiociaoRnait; BIOOD PMSBI; i WTS
I KOPUSSS; J1P1I; 6JSTEOIII1STII11 | Fvkaoka Mdlcal Joacmal
| STSTIB; PISTICIDES: 1HIP05! USSQI; | C« (10t«10-C1«
I IITEB: KIDIIIS; OHSlCTS |
1 |
1TS.T ag/kg ( HctatiB? fetter* I Kodrlc-Silt, 8.
1 1 Salt, Z.
1 17-41 re oldi froi Slaronla Protlgca, | die, S.
I loqaalarla. | 1980
1 1 Pesticide* sonltorlng
1 TIGQStaTti; 11CTJTIOI; BH,Ki | joaraal 1» CDs 1-2
1 iiotccviaimon; JBBII IBBIS; i
< caeiimTiD eroBocassois: catOBiu i
1 oisinc ccapcojos; CRIOHOBHIBBIS; i
1 rci: BUT: BgucEioaocicioHiiuB; i
1 FISTICIOES |
2130 » or - 1*50 ppt ( Bilk bank aonota | Hacrol. J.B.
1 1 Jsqoith, B.T.
1 Callfociia | 1980
1 1 Vev Sagland Journal a£
1 CUIfOnil; ten-IS; BHK; 1 HediclM
1 •loiarrironTioi; LICTITIOB; DO:: IDT: i 303 (16) :9»s-9*£
I PSSTICIDIS |
1 1
1 |
1 B»i«r | Oaichaan. (.B.
1 1 HacMmald, V.I.
1 tsposcl peraeis in the Onited States, I 1»71
1 tae fetkaclands, s«ede», Israel. t Boot oxieo logy »d
I Japan, VSS9, Polaaa, Seriaajr, India, I EnHroBaental safety
1 Balgarla, Pakistan, Kstria. I 1:89-110
1 |
1 Beported cans of brpertenstcn, I
1 derated serua chalesterol, abnocaal |
1 lies, or lapalrsent of nenrouscnlat f
1 Inaction *fttr acute axposmte to 1
1 coabinatlom of pesticides, but lost I
1 data show no adverse effect! after (
] lens-tern occupational eiposnre. 1
I insHia: EBtsisri: estsitr; noil; i
1 ISSirt; J»PII; KTRI811BDS: T1KIST1I; t
I tciiio; BH5SU; SVEDBI: USHID i
1 ST»TIS; ICIF05E XlSSVii BlOOt: B1OOB |
1 PUSH; BICCO 3EBOS; ISTTBBOCTTES; |
I IWItOCTTIS; (IIIKJ WRI»I; BETIE1»i |
1 gitiTB sirtsrs; OOCVMTIOIIL BIZJBDS; i
I 5CP011TICK BXPOSOBB; JIOPUSHS; |
1 PZSTICI9IS; CBLOBIIE OSGaaTC 1
1 CCBPOOirBS I
1 1
«.64g ppa | «) (oral sctkera, fat basis t Pozo Lora, B.
5.833 ppa | \) Urban lotkers, fat basis I Berrera Barteache, 1.
6.263 ppa | c) 111 .others, fat basis | Polo Tillar, 1.9.
0. 11» ppa 1 d) 111 anthers, nhole ail* basis I Lopez-Gltenez, B.
1 Cata for sna of all pesticides and I Jodral Tlllare^o. a.
I ccifarisons vith valoas of other 1 Iglesias Perez, J.
1 lirestiaatoti X HE'KS; TTOBal IB? IS I
1 1
(HIT PIGZt
-------
Itliylene,  1,1-dlckloro-2,2-bi8(p-cklorophen7l)-  (8 CD
Eenzcira, 1.1>-(dlckloroetkeoylidene)bis(4-ckloro- (9 CI)
7Z-JJ-9
C14-M-C14
If 318.02. If 88.* C
                                                                                       (COITIIIIED)
tlSSdl



3*60
Silk, fat














3481
Oaentai








3982
Placenta











3983
Placenta














MOSOSS W30T1


























































atalTTICaL
KETIOD


ec-BC

























GC-EC












SC-EC















IOBBS3
OF C1SIS


















1









50












a) 25
W IS
at 10













BUGS



) lot given
) lot givan
I lot given
) lot given
) lot given
) lot given










lot applicable









37-19 ppb












*) 3-42 ppb
b) 7-5* ppt
C) 7-19S ppb













nil | exiHii iiroiRaTioi
1
1
1
) 1.71 + or - 0.88 I ») 1972, 40 saaples
pa | b) 1973. 31 saaples
> 1.98 + or - 1.51 1 <=) W«. " saaples
pa j t) 1975, 20 aaaplas
) 1.9« « or - 1.0» | «) 197S, 19 sa.ples
pa | f) 1977, 20 naples
d) 1.92 * or - 0.79 I
ppa | 100-1*1 lactatinq voa«n, 2 lonths
e) 2.02 * or - 0.99 I alter deliTery. Bes Wants of Osaka
ppa | Eca lecture, Japan, varied diets and
:1 1.60 » or - 0.6* 1 «n»irometit«l conditions.
ppa I
I J»P1I; aDDlTSs LkCTlTIOl; BIIK;
| EIOICCUHOliTIO>; PISTICIDIS; DD<;
I oi6»ic cmonn COHPOJIDS:
| fOlTCHLOSIIaTID BIPHIIILS
20 ppn (fat basis) 1 «* Tr old >al« »ith stoaach cancer
I
1 Japan
1
| ICLICHlOSHiTID BRBIITIS: DDT;
| BHICHIOBOCICLOHHIIE: BLOOD P1»SB»;
| ItO?tlSBS: JlPaS: CtSTSOIIlZSTIIaL
| STSTBI: PISTIC1BE5; 1DIPOSE US SOT;
| IITIB; HtHlIS; OMIT1JB
1
50.54 ppb | 31 positive specinens
GeoMtric 1
j Ptaqnatt voaen, siailar in
I iccloa-coaonic l«>el aafl dietary
j babits. lo eccnpational or
j accidental eiposnre. t.ac1cno«. India
I
| HSTICIDtS: CHlOlIltTIO HIDBCC»BBO«S;
I cnoBiii osGinc COIPODIDS; ODD; DIB;
I en; noil; PIISIIICT: IHSIOTIC
I iinio; ?i»cin»
i
I
a) 11.9 » or - 11. « | a) Controls, fall-tern pregnancies
ppb | t) Pre-ters pregnancies
b) 31.2 » or - 15.0 | c) Spontaneons abortions at less than
ppb | 8 «tt (inclades fetus)
c) 93.6 « or - 69.3 I
ppb I Bealtky. non-exposed, preqnant nonen.
| ages 19-32 it. India.
1
| IIDIa: tBCRTIO*: aDOITS; TITOS:
1 110CD; PLlCIRa; COBPlBiTITI
| ITHOlTIOIS: CH101II1TIO
| BYtSOCUtBOlS: CHLOBIK ORCkllC
| CCRfOTKDS; II5ICTICI9ES: ISSIICIDIS;
| fISTICIOI HISIDDES: POPtlLlTIOl
| HPOSOBS: PBIGIilCI
1
BEHBEICZ



Takasaiji, T.
Vataaabe, I.
Knvabara, K.
ToshUa, S.
Koyaaa, K.
Huita, 1.
1»79
International archives
of Occupational and
Environmental Bealtn
»3:1-15





Inoae, T.
Abe, s.
Takanatsa, B.
>okl, I.
Biki, s.
Fnjiwara, K.
1975
rakuoka Badlcal Journal
66(10:610-616

Saxena. I.e.
Setk. T.D.
flahalan, P.I.
mo
International Journal
of Environmental
analytical cienistry
7:245-251





Saxena, R.c.
Siddiqai. B.X.J.
setk, T.D.
Krishna Rorti, c.s.
Ehargava, l.K.
Kitty, D.
1981
Journal of analytical
Toxicology 5:6-9







-------
flsorlte
1698*-*8-8
f
It! 18.998*



1ISSVI
398*
Hood.
plassa
3985
Blood,
Plasaa
39tf
Hoot,
ser»
87
lie
3*88
Brill*
BirOSOlE BOOTS aULRICU
BRBOD
lagestios ISj
Isgestlon

lahalatioR
Tngestlon
colorlMtry
ISB
ec

s
•DUES 1 I1I6S | mi | GtllBlL IIPOBS1TI01 I 1SFI1BICE
or C*SM 111 i
III 1
III 1
* I ») 1«-20 »g/»l | a) lot give* | a) tefore vanish application to 1 Ekstrand, J.
1 b) 60-120 ng/nl I b) lot given I t«eta I Koch. G.
1 1 | t) attar Tarnish application to | Potersson, L.B.
1 1 I teeth, dose 2.3-5.2 *9. peak at 2 hr 1 1*10
III I Caries Besearch
1 1 1 «-1» Tr olds | 1«: 185-189
III 1
I i i FtnoMDE: BICOD nasai; CHUDBM: i
1 1 | Mill: SIIDZI |
iii i
26* | a) lot gi.ni> I a) S. 00 » or - 0.27* | a) 10-20 Tr old* | singer, 1.
1 b) lot given | oaol/1 1 b) 21-30 Tr olds | cphaog, I.E.
1 c) lot given ) b) «.7» + or - 0.216 | c) 31-«0 yr elds I 1979
1 d) lot given i naol/1 1 d) «i-so yr olds I clinical Cnenistry
I •) lot given | c) S. 58 * oc - 0.316 | «) 51-60 re elda I 25 f«> SS23-S25
1 f) lot given | nsol/1 | f) > CO rr old 1
1 1 d) 5.«6 » or - 0.295 | Ifter consoirtton of fluoridated 1
1 1 naol/1 | »it«r (1 aa/1) > 1 yr I
1 1 •) S.«7 » or - 0.326 | |
1 I oaol/1 I Beside its of n I
t 1 f) S.58 * or - 0.3*2 I I
1 1 naoVl 1 IIIIBSOTI: 1 CHITS; 1GS; CHIICBEI; |
1 1 1 IIOOD JtlSBJ: C01P1MTITE I
1 1 1 !1U0»TIO»S: FLOOIIEI; DBIIKIR6 «TtI I
III 1
1 II 1 " "'
1 • I a) 0.0*-0.06 ppa | a) lot giren { a) Controls | Obel. ».».
IB | b) 0.01-0.07 pps I b) lot given | b) laboratori persoBMl, > 20 TI 1 Socenson. S.D.
I *9 |c) 0.01-0.09 pps | e) lot given | eiposir* | Roach, D.I.
1 1 1 e| Frod«etiea vorkers | 1980
III I Isericaa Industrial
1 1 1 lerkers at aaaoaias | Hygiene Association
1 1 1 Ferflaorooetasoate prodnctloa plant. I Journal «1:58*-589
1 1 1 ftOOSIfl; IIDOSTBIll «ltRS; B100D I
1 1 1 snag: occqpnioiu. BI±»BBS: B»S: i
1 1 1 FlflCBIDl; PlIOBin COSPOOKCS; |
1 1 1 IIBUSTBIlt HMSPHSBES |
1 1 1 J
1 1 1 1 	
1 a) 6.5-18. e ag/1 1 a) 12.02 ag/1 | a) tofor* local exhaust ventilation I white. D.I.
1 b) 0.2-3.2 ag/1 | b) 1.«1 eg/1 | b) Ifter ventilation | 1980
III 1 Joarnal of the Society
1 1 1 Scottish factory workers exposed to 1 of occupational
1 1 1 "- I Bedicine 30:12-1*
1 1 1 SCCTLUB: OBIIE: FL001IDE; mnSTBIU I
1 1 1 aTIOSPBEBES; OCCOPtTIOIU. B1Z1KES I
'•I 1
1 1 1 | 	
1 a) lot gives 1 a) 100 ng/12 hr I a) Before Tarnish application to | Ekstrand, J.
1 b) lot given I b) 200 ug/12 hr | teeth. 2 yomxjer children | Koch, 6.
I c) lot given I c) 5SO ng/12 hr I t) Before varnish application to | Petersson, l-G,
1 d) lot given 1 i) 1. 100 ag/12 hr I teeth, 2 older children | i*«o
1 1 le) Ifter varnish application, 2 | Caries Besearch
1 1 1 voisger children | 1«:185-189
1 1 Id) after vanish application. 2 older I
1 1 1 children |
1 1 I rose, 2.3-3.0 nq for younger children I
1 1 1 and 5.0-5.2 19 for oiler ones |
III 1
1 1 1 *-1* yr olds |
III 1
1 1 1 IIOOBIDE; SLCOO PUS1»; CHXIBEII; |
i i i ciiiz; SIIBZI i
- - 1 1 1 1
-------
flierlM
7782-«1-«
r
Itl 18.99M.  op -2I9.«1 C, IF -188.13 C. If 100 mm Hg at -203 C
TISSBB
3989
Blood,








nPOSOBB MOTE









AIAITTICA1
HITBOD
ac








mass*
or CASES
at *
b| *
O »9








IAI6E
a) 0.01-0.08 ppa
b) 0.04-2. CO ppa
e) 1.00-71.00 ppa








mi
a) lot given
b) Wot glTea
ct lot given








GEBZBlt IirOBUTIOB
a) Coitrols
1) Laboratory personnel, > 20 jx
•xpoair*
c] Prodictioa tOEkeca

forkera at aiaoaloa
ptrf luorooctuMatat ptoonetion plant.
flOOBIR; IBEDSTlItl PLAITS; 8100D
SEBBH; OCCOP1TIOBU, BISABDS; BITS;
ItBCBIBB; TLOOBIIE CCSPOOIDS;
IIDDSTEIAl UBOSPBISIS
tEKBIBCI
Ibal, F.I.
Socenson, S.D.
loach, D.B.
1980
aaerican Industrial
Bfgiaae Aasociation
Ooarmil »1:58»-5B9




113-39-7
ei-BS-i-o
» 59.01, BP iao-ies c
1 ISSUE
3990
VElM











3991




BXIOSVB IODT1
latalatioa
Da rial











laaalatloa




AI1L1TICU
BET HOC
ec











5C




OF CaSXS
22











9




"BGB
a) lot airai
b) lot given
e) lot alien
d) lot qlTea










0.«- 19.56 .O/O.T




BUI
a) 19.9 * or - e ag/g
creatiaine
b) 63. 0 + or - 16
aq/g creatialae
e) 10.3 « or - 5 ag/g
creatlniae
d) 22.6 * or - 8 ag/g
creatiline







lot glTea




CIIZBA1 IBTOBBITIOI
a) Before >otk, 2ad da?
t) after wort, 2ad day (expoaare 92. «
* or - 21 ag/ctt a « kr
c> Before »ort 5tV Jay
d) After work Sth dar (expoaare SI. 7
* or - 7 aq/cn a i hr

31-»7 TT old voikera in acrylic fiber
factory.
icdoaiul. qastric pai».

VBiiii anitcmES; EIIGIDB;
CCCHPATIOI11 BAZABDS: BEALIB HAZAEDS;
H5HSTBIH AtRasmtis; IHBOSTBIAL
I11BTS; SJTBtl BADtCALS; IBBAlAItO*


20-29 TT old factory nortera, Japan.
I1IBB; 9ITA301ITBS: J1FAI;
CCCOPATIO»»1 BAZAB9S; BBA»B HAZABOS;
1IDOSTSIAL AlflOSPHCRES: ZIDVSTfiXAL
BHEEtIC!
lannerfa, E.B.
riTita, A.
Biqolet. ».
Eanbean, D.
Backet, J.S.
Roels, E. A.
1990
International ArchiTes
of Occapatioul and
CDTiroanental Bealtk
•5:1*9-203




Toneaoto, J.
SnznU, S.
1980
International Archives
of Occ«pational and
EaTiroaaeatal Bealtk
•6:159-165
                                                                                                                                                                                           U)
-------
  !oriMi4«,
  CJ-S7-I-0
  B» 73. M.  IF -61C.  IP 153 C at 760 •• E«. 7C C at 39 » B}, 25 C at 3.7 M Bo. TP 3.T  »  B« at 25 C
IXSSn
3992
trcata













I IIMSOJJ SOnil
Inhalation














lULTIICJL
RETROD
BC














BOBBM
OF C1SBS
a| 5
it a
C) 7
d) 9
•1 8
a ^
« «
h) 5







iiies
a) 4.9-2.9 ag/cu
b| 0.4-2.4 ig/cg
c) 0.»-2.a lo/co
4) 0.1-2.9 ig/cn
•1 0.7-5.1 mg/cu
f) 0.7-».9 «g/co
9) 0.7-7.1 cg/ca
k) 0.7-*.« «9/ca























an
a) 1.7* ig/cn >
b| 1. t »g/c« •
c) 1.27 *g/aa •
fl 1.5 »g/c« •
•) 2.23 *g/ca •
f) 2.07 iv/eil •
3) 2.( >g/ca •
h) 2.3 «9/ca i







6XKML t»ro«mrioi
•t 0909 ir
b) 1000 kr
cl 1100 hr
91 1200 kr
«) t*0» kr
tl tSOO kr
41 1600 kr
h| 1700 kr
saifle tlmfs dorlag • kr shift
lectots In artificial lutt*c
factory. Italy
Hill; tDDLlS; BHaTB: SOLTBWT3:
FUBISl HJ1LT1 RAZUDSs K005TEUI
JITO3PHMZS; I»B1HIIO»; OCCOPlTIOJil
I111IDS
unuicB
BTtgnoM^ F.
Parbcllial. 1.
CalCnri, I.
IfSO
Britlak Journal of
Iniustcial HeiiciM
37:1«5-1«»








fatal
|tO-00-9
t«-a«-o
>1 68.07. RP -8S.6S C,  BP 31.3C C
I TISSU1
1
1
1
1 3993
1 Breath
1












39««
tr«atk













BIVOSHIE ion
















. _
















1I1LTTIC11
•erioo


ec/as














GC-BS














man
or cisss


8












_

5« (387
saaplvo}













Miec



lot d«t»ct«d-98.0 g4/hr














lot giraa














»B»» Giiitit urotBinoi



21.3 <9/
-------
tmllltm
7MO-55-3
c*
Itl C9.T2, ft 29-78  C,  BP 2*03 C
TTSSm
3995
laic

















ttttaam earn*



















1I11TT1C1I
SETHOD



















EOSBSS
or USES



















IMG!



















"*'



















GrilUL IITOSBITIO1
levin. 2* rei>rese«titl»e
pie-anal yds tceataents ace
tafcilate*. Tbe feasibilltT of a
kolistie, no-«ask policy foe kale
••alTsis is ootllmed a*d sapjoctei.
Kim: TBICI ntRSBts; s»ii;
*
-------
           *- (2-setarUe»zo7ll -
  C10-H11-I-03
  (1  193.21
1ISSOI
3»97
oriae











tZPOSOlt BODTI
Inoestlon
laaalatiOD











RRB09
BFLC











IVIBSS
or cisss
a) •
b) «
c| 2










(IKE
a) lot glvaa
b) lot gi»«n
c\ ff-O. t» sg/sl










fUt
a) 0.122 » or - 0.00*
b) 1.2 « or - 0.4
•g/al
c) Mot glma








GEBIIll ItPMBaTIO*
• ) 2» kr cxcretloa after 0.3«*
•*ol/kg oral dose of o-rylt»«. Peak
IB 3-* be
t) Ifter 3 ht exposure to 13» pp»
c-xTleae vapor. Peek at 3 ar
«> Paiatera. Xstlaated fro* orapa.
Diiraal variation.
volunteer!. Man ages 53 jc (oral) ,
«« rr 
-------
7MO-S7-5
Itl 1»S.»6«5, IF He*. 76 C, » 7700 C.  W  1 mm  Ig  at 1M» C, 10 •• Ig «t 21CO C
TISSIl



1000
*Waej




















W01
U*ar





















4002
laag






















nosns tagti








































































immcu
BKBOD


n





















n






















n























nrnra
or cisss


8
21




















») e
b] 20





















4 8
b| 9
d 11





















iiiei



< 0.00001-0.0011 ag/g
< 0.00001-0.0021 ag/g
•t «t



















*| < 0.00001*0.000*6 »g/g
bj < O.OOOCt-0.0010 19/t
tat lit




















•) 0.000080-0.0079 oq/g
b) < 0.00002-0.01* og/ij
e) 0.00024-t uA teatk 0-1.5 IT
\ la fttap I *•« 2-19 fc, gto»j II.
I cntcols, aqaa «3-72 rr. «ko llnd SO
I »i {xoa tb* factorr. S««4«n.
1
| !1!»S»: C1I»Z8S: IIDIITS: tITII;
| IVTCSt CO»»IITIfS mUHIOIS;
I iiDosTiiii tieinii nisniEim
1 siTBoes; imsoii: ustiic: CIDIUJB:
| CISIOP1; CnOROl; COtUT: COFPIl;
1 «CLH; iio«; umiuwi: HID:
| I1IMIESI; M1CUIT; ROITBPIim;
1 iTOswoBDS: ivaiBini: SCHDIOB:
| SIIHI35: 5I1TSB; Til: TOISSTII:
I IMC; II11T1 IK1SDS; UDOStlUt
i tiins; smms; Tmmioa
a) lot gi»e» I a) Coatrol*
b) lot gii*a | I) VoikarB, groaps I aa4 II
1
1 I«c«aaal r«flMcr and a»lt»r
I toikcn. »gai SS-7C jt, •z^oced to
1 Icavy actala 1-3 4acad«s. Tiae
I tct**«a rctlnaaat aa4 teatk 0-1.5 yt
I la gcoip I aal 2-19 it, groaj II.
j Coatcola> aq«a »3-7J ji, »ho lli*a SO
1 1 • fcoa tk« tactocr. $••!•>.
1
1 aiuii: ciouns: riwiis: mm
1 IBISS: COWUITITI mtOlTIOlS;
1 imosnm Bteins; msoBtatrr
I HIIO9S; niTisoii; iismc: c«Dnra«;
I cisn»: craosnii; COBILI: conBS:
| SCID; 1101; IHTBIIOH; LEAD;
1 iMsutsi: iiBcoiT; BonsriftHi:
1 {BOSfBOius: straiDlui: scitiiOR:
| Slltnil: SIITIE; Til; TOIOST5S;
I ZIfC; IStlTR BIZISBS: I»D9St8I»L
| tllrtS; SHSITCTS; TIUmiDB
1
a) 0.00062 V)/i | a> Controls
b) 0.0017 ag/g ( t) larkac qrcup I
c> 0.0023 og/g 1 e> lacker grnp II
nt »t i
a»li»os | tcc«*aa4 ccflMcr tai nelt«r
1 lockers, aq«i S5-7S yr. •xpaacA to
1 b«»TT wtaH 1-3 tacaft*-. Tiae
| t€tM«H ntlXWMBt U4 3«tk 0-1.5 TC
t tn group I and 2-19 TC. gtoap II.
I ccatcola, agas »3-72 rr. »1ia lii«l 50
1 k> fraa the f actor?. Svedaa.
1
f SHDZt; ClDtfmS; KIDSnsj 11TES;
1 toiGS: con?»iTin mintTiois:
I unnstatn. vtettrc; seisoaiBirr
1 stiBODS; ntHom: IBS me : CIDSITJII:
1 CISIUR: CBSOHWB: COBUT; corpn;
1 eciB: IJOP: I»TIM«I: LJ»D;
I 8»Gtnsi: tmcun; ROITBPIIOR:
1 ccosrwngs; BVBIOIHS; sctigioi:
I SHEfXIM; SIITEB; TH; TO«SSKIi
| -JIC! a«»lTB BIIJBOS; I1DOSW41
1 flirts; sunnts; TtLi0
Scl««c« of the Total
raviro*a«t 16:13-15

















Bcana, D.
locdbeig, G.
V«ster, P.O.
1980
Sctoace of tba Total
Ia»iro»«»«t 16:11-35


















(HIT P16IJ
-------
   «cia
   7440-57-5
   In
   I« 196.9665. HP 1064.76 C.  EP  2700 C.  TP 1 •• tig at 1869 C, 10 an 89 at 2160 C
                                                                                         (COETT.BOED)
TISSUE
«003
Hall















SIFOSHBE BOOM

















immcii
BET BOD
»
















101 BBS
Of OSES
a) 9
b) 11















sues
a) Wot given
b) lot given















mi
a) 2.64 * or - 3.81
PP»
b) 0.«2 * or - 0.32
PP»
Dry lit












GBIEBIL IIFOSBJTIOI
a) «oian
t) Ben
left thiab
Use revieved; knovn levels ot 30
other ele««ts

Bealtkv 20-60 re olds

HOLTS; SCI: IIIIS; BBflM; UDBIIHB;
IITIBOII: IBSCTIC; BIHIDB; C1DBIUS;
caicni: cisioa: CHBoaing.- COSIIT;
ccppra: eiBBiiinB; GOLD; isoi; uig;
xensiiiH; Hiieiiisi; RISCOXT;
lOlTBDIIBI; RCKBL; fOTJSSIUB:
BHBIDI1R: SBlZflOB: SI1ICOII; SILVIB;
joetnR: SIBOITIQB; Tt>: TITIIIHH:
1H1DIVJ: ZIK: ZIBCCIIDR
BZFSBERCZ
Xanabrockl, E.I.
Kanabroeki, J.I.
Greco, J.
Kaplan. E.
Oester, T.T.
Brat, s. s.
GastafsoD, P. S.
Kelson, D.I.
Boor*, C.E.
1979
Sclenctt of the Total
E>TiEon»ent 13:131-140





  Beptane
  142-82-S
  C7-116
  f« 100.20. IP 98.52 C. TP 40 •• Bg at 22.3 C
nssra
4004
Breath












FIFOSOBI IODTE














a»tmc*i
BETROD
GC-HS













inaaxs
or cisis
54 (387
saaples)












EIIGI
•ot given













BUI
1.8 09/1
Geonetric












GEIII11 IHfOBBlTIOl
Beanceil at 25 c and 760 » Hq
47. 0* occarrcnce
lover and upper one-Signa lialta 0.69
and 4.7 nq/1

BealthT. 18-35 ji old, nonsmoking.
nrfcan blacks and Caucasians.
Chicago, It. Rigidly controlled
eipcriaental conditions.
I1I1TB; JICOBOLS; I1LIIOIS ; 1DITITS;
CEIOBIMTII BTOBOCaBEOIS; 7O11TII.B
CfSUlC COBFCOMDSJ HULTH B1Z1BDS;
IIH»HTIO»; Brtuonsa; BXTIBOLITES;
COPOLtTIO* EIFOSOBi; OBB1I tBElS
BETBBEHCZ
Krotoszynski. B.K.
Brunean, G.H.
C'Belll. B.J.
1979
Jovraal of Analytical
Toxicology 3:225-234








                                                                                                                                                                                              oo
Beptan. 2,4-diaethyl-
;J13-2J-Z
CS-B20
(I 128.76, !F 133.5 C
tlSSBl
4005
Breath









t
t
\
»
EIPOSOBE EOUTI











\
I
\
\
1IJIITICIL
BETHCD
SC-BS











1
I
t
IDiBIB
or cjsss
5« (387
saiples)













illGE
lot given














mi
0.267 ng/1
Ge one trie











t
I
GEBBBli IRrOMlTTOi
(•asared at 25 c and 760 •• Bg
46. 5< occurrence
lower and upper one-Sig*a Hails
0.0«S aad 1.5! ag/1

1««lthT, 18-35 jt old, nonaaoltinq.
nrtan blacks »d caacasiaas.
Cfclcaqo, 11. BiqldlT contcolled
• xveriMetal conditions.
ISI1TH; klCCBOlS; IlltlOIS; UD1TS;
CB105T11TID BT9-BOC1BBOIS: VOIlTItX
ctetiic coiifcncs; BEIITB mziBis-.
llflllHTOI: BITIB01ISR: BI1WOHTES:
tcrnnTTOi ixtosims IBBM uzis

PIFEBEHC!
KrotosTjnski, B.K.
Brnnean, G.I.
O'leill, B.J.
1»79
Journal of Ualytieal
TOTicologr 3:225-234









-------
        ,  2,5-diMtari-
C«-B2O
BI lie. 25, tt 136 c
tisstt
»00«
truth












arosast WOTS














luimcu
BET8OD
CC-SS













» oasis
or ctszs
56 [397
oaipl«s)












fl»GE
flot givfll













Bill
0.083 09/1
Geoaetric












SBKBII nroaa»Tio»
aea*area at 25 C »a 740 II B«
21.25 occurrence
to»r »3 op par ooe-Sigia Halts
0.019 in a 0.353 Bq/1

BealthT, It- 35 TC oil. noniBOfcia?,
«tn black* u4 Caucasian*.
Chicago, IL. BlgUlr conttollea
etpcctMBtat condltioos.
ESIHB: 11CCS01S; IIUIOIS; UVLTS;
CB101IHTID BIDBOCHBOSS; 1014TILE
CBGIITC COBfCDUDS: BI1I.IB BIII8CS:
IHIHTIOI; IRtBOlXSI; RITtBDIrrES;
tCTDtlTtQI tlPOSDM: VSBK 1BUS
sxtttstcs
tratoazjncti, I.E.
Broi«»f S.B.
O'lteiH, B.J.
197*
Journal of In&lTtic&l
ToiicologT 3:225-23*








S«ptrl alcebel (a CI)
1-M;tuol (S CI|
111-70-*
C1-H1«-0
II  116.2. » -3».6 C. BE  175.8 C. TP  1  ••  Bol ci»ill«li
erplofeea, n.s. lit Torce Sctool of
l«rosp«c« fledlclnev a^«s 23-*7 rr. 3
stokers.
tllZEBIS: CIlQSIflLltl STDECCKBOSS:
CE10BI1! OBOinC COBCOraSS;
CElOSamtEIIS; FLDOEIK COHIO11BS:
fEUTB; II-CCIOL5! TEHS: 1DOITS

BEFZBEICE

Coakle, J.?.
Caap. B.J.
nelch, B.E.
1975
•rcoiTes of
Eavlronaental Bealta
3 0(2): 2 90-295




f
1
                                                                                        (SHI P1GZ)
-------
   ICXtM
   110-S4-3
   CC-11*
   B1 86.17.  BF  «8.7 C. T*  100  ••  Bo.  at  IS. 8 C
TISSUE

400*
£t««th












trrina










siposoB! BOOI














I»kalatio»
Bataal










1 ZURICH
9STHOD
ec-ss












ec/as











BOBISB
or cisis
5* (387
saiplas}











10











HISS

Krt »1T«












a) 0.1-1.4 ««yi
b) 2. 9-30. C •»/!
c} 9.7-5.5 »o/l
4) 1.7- 17. S aj/1








SBl»

t.7 a 9/1
6a>oaetrlc











a) 0.5 * or - 0.4
•«X1
b) 10.1 « er - 8.3
•9X1
c) 2.4 » or - t.7
•4X1
1) 5.2 » or - «.e
•aXl




SZBZZIL lirOIBITIOl

e«i»ar«d at 25 C aid 7«0 as Rg
6.9% occttic^Bca
laiar i*i »?F*r oM-Slaaa Haiti 1.63
a«< 13.5 aq/1
B«altkr. 18-3$ rr ol£, aonsaokiiiq.
ntln blacks and Caucasians.
Caicaqa, II. SioldlT coatrollei
«xp«riMatal conditions.
ESI1TH; HCOBOLS; 11LHOIS; IDB1T5:
CKClIHIfO etDBOClBBOIS; TOIITHE
cieinc coapctjiDs: BIIITB BITIBCS;
JiaiuTioi; miBoiisa: MTIBOLITBS:
IC?BUtTOB ElPOSOIt! UBBI* UZtS
a) Is 2-baxanl
tt Is 2,5-b«zan«aloa«
c) Is qaaaa-Talerolactow
S) Is 2,5-Ua*tk}lfaraa
9«tabolltai
lata alia aa animate In factory air

letters in ikoa factory in Italy
aaizfc: ITCIOCIZBO*S; BZIIBOLITIS;
Ilitt; IIDOSnill tTMSMEBES:
ncosnm treizzt: us roiLmoi;
occvrnioui DISUSES
nntEicz

KcatoazjuliU B.K.
BCQIMail, Q.S.
0'Walll, B.J.
1»7*
Journal of laalytical
Toilcolwjy 3:225-23*








Petballlnl, L.

Pa»a», I.
19AO
Toxiooloqr and Ipplled
Pbaraacologr 53:229-229






Kxan, 1-ctloro-
•M-10-S
C6-BTJ-C1
II 120.62, a* -«* C, tt 13* C
r TISSUE
«011
B»atn












zirosmi IOBT?














mtnicii.
BETROD
SC-BS













•mm
or CISES
S« (387
saapl«s)












*IIGI
•at gi*«













BUB
0.121 ag/1
Geoiatrlc












«ZBI»L IITOtaiTIOI
e«a««ra4 at 25 c aid 7«0 aa 89
27. ?% oeeatrcne*
lc««r aai app«i: oie-Sl^M 11 alt a
0.033 aad 0.«34 a.j/1

IcalthT. 18-35 rr aid, aonsaotiag.
•Tta« blacks u4 cagcaslan*.
Ckieago, It. Maiair-coatrolled
•x|:ccia«Btal conilltloas.
HEITR; ilCCBOtS; HLIIOIS; JOBtTS;
CKOSIUT10 ITOIIOCIBBOSS; tOUTILE
cs-:irrc cospcoiDS; RZILTI BIIISOS;
niitnic*: «ET»EOLrs»: SEWBOI.ITBS:
POPOHTIOI {IVOSKSS: tIBBaB IBZIS
SBrfgEJCI
Frotossreskl, B.K.
Bra«a««, G.a.
O'Mlll, B.J.
1979
.loiraal of Inalytlcal
loxlcologr 3:225-23*








-------
(nan. 2,3-«Mtarl-
;««-*«-!
cf-in
Bf lit.23, Bf 116 C, TV 10 •• Hg «t 9.9 C
TIS5BI

•012
Bnatt












BMosnE xoni














1IURIU1
8ETICB
K-BS












•MB!t
01 CUBS
5» O*7
caaples)












MKI

•Ot giT«»












mi
.
1.« •«/!
Sooaetric












CEIIBlt IIFOtBlTIOl

Bcamrad at 25 C and 760 •• Hg
31. 81 occittcncr
lever ul tppar ona-sLgaa litita 0.57
ami a. 5 »q/l

MaUkT. «-35 Tc old. nou«oki»).
•ct« blacka ua CMcaslaas.
Oileaqo, n.. Slqldlr controll«J
«ip«rl««»t»l coo4ltio»s.
HIKH; IICOBOIS; IUIWOIS: U01TS:
c«io»i»«m «n>*oc*iw>is: rautns
ciemc coBfcoiBS; anna snitos:
initmoi: IRIMLISI; Bnimms;
rOMUIIOl IIMSOKE; 0«B»« 11E1S
BirESZRCE

KrotosifiMki, B.K.
Sraneai, C.H.
O'Ksill. B.J.
1979
Jamal of lulTtlcal
Toiicoloqr 3:2SS-23»








IciaM,  ].3.S-trlMtkTl-
ice«-53-a
e»-B2o
II 128.1!, BP -1JT.8 C. BP 131.34 C
1ISSBC

Bctatk











EsnsiBB toon













auirncu.
BETVCD
8C-BS











B0BBH
or cisis
54 (387
•uples)











SU6E

lot gl»«a











BEil |

MOM trie











eniui uroBBnioi

Manc*4 at 25 C and 7(0 •• Bq
SI. If occirtem
t,o««E wd «pp*r oa*-sia»a limits 1.7
aad a, a aq/l
'
MaitsT. 18-35 yc aU, nomaoklag.
artaa black* and caveasiau.
Ckicaqo, IL. Rlqidlr coattollad
aipniMital coidltioas.
tlllTB: ILCOWLSJ I III SOTS; UV1TS;
CBlWltti jp nioVOClBMIS ; TOL&TZLS
CKMK coifcmres; BULTI aunts;
IIBltMIOl) 8BT1EOIISR: K11BOLITIS:
ictvuTioB iiposani; DBBM »Bts
BBf»«HCI 	 ~~

Krotoszyncki, B.K.
Bruwaa, S.B.
C'Halll, B.J.
1979
Joanal of laalytical
Toiioolojf 3:225-234







 9li«M. 3,a-dlMtkrl-
 583-W-x
 cf-ne
1HSBI
1
«01»
Braatk











ITKISDK BOOK














tlUTtlCU.
HCTBOD
«C-RS












IOI1II
or ctsss
54 (387
savplfed)











IIIGI

lot glTci












BEH

3.7 a a/1
Geometric











GUtllL IiraUTIOl

(caeared it 25 C aad 760 la Bj
43.2^ oecvrrcnce
ivme aal appar out-siqaa llaita 1.7
a«l 7.4 iq/1

BealtkT, 18-3S Tr oil, Bonaaoklng,
or tan blacka a»d caacaslaaa.
Chicago, It. Uoiair contiolled
eipariceatal conditions.
null: iiccEois; IILIIOIS; wuits:
CilOBlaiTID m>BOCllB01S; lOIJ'It!
cteiitc codtCTiiBS: HEII-H BIUEDS;
iimnTioi; imioiisi!: BSTIBOLITIS;
KPVUIIOI EIPOSOK; VIBtl alMS
MTttMCB 	


Brncaa, G.a!
O'leill. B.a.
1979
Joaraal of analytical
Totlcoloqy 3:22S-234







-------
   252M-93-1
   ee-«i2
   •I M.1S. IP -139.9 C, BP Sa.5 C. TP 314 •• Hg at 38 C
TISSJ1
S015
Breath











HPOSqES BOTIIB













IIIITTICIL
BETgOD
oc/ss












BUHESB
OF CaSBS
8












I1IGS
lot detected- 1.3 ng/kr












BEH
O.S «g/-hr












eiizFii I»FOSBHIO»
Ccapoml fres tmfcaovit origin. lo
ether Ja tails giren
Cryogenic saapllaq technique.

B«althf silitary an! ciyiliao
eaployees, D.S. lir Focce School o£
l«rospac« Heflicioe, ages 23-47 yr. 3
siokera.
BHIH'SS; CBIOBIIITtD BIDBOC1EBOSS :
CBLOaHI OBGIIIC COWOOSD5;
CHLOBOEjrZIUJS; FLVQBIRE COBPOUICDS;
E1I1TB; HOOBOtS; THIS; 1BOLIS I
1
EiriBEICS
Conkle, J.P.
Caap, E.J.
»alch. B.E.
1975
Irchives of
E3Tiroa«ental Bealth.
30r2)s2SO-295

.


1
1
   Blppmlc *ci«  (S CI|
                         cr>
  CS-M-l-03
  II 179.17. BP 187-188 C
TISSUE
»016
ntlna








I
EIPOSOSE BO Oil
I.halatlon





1
I
1
1
njirricii
HITBOD
HflC









(OH BSE
OF C1SI5
2









BlIGE
0.42-0.46 ig/ml









9E1>
Rot qirex









GEIIEIL moMlTIOil
Cccapatiosallr ezposea to o-rrlene.
Dliraal farlatlaa. istliatei fro a
naph

Kilters, lean age 32 yr

mm; arriBOLiTES; occwuioiti
HIIiEDS; POP011TIOI tlPOSOBE; BETBTt,
EIDICilS; PURS; MB1UIIOI

1
ElFItErCE
Ogata, I.
Yaaazalti* T.
Sugikara. K.
Shlaada, I.
gegaio, T.
1910
Interaational Ircbires
of oocapational aa4
EBTico»ental Sealtb
•6:127-13*

tlpplrlc acid, i-Mthfl-  (S CIl
ClTclM, I-(3-««tbrUw»OTl)-  (4 CI)
C10-I1T-I-03
CI 193. 2 T
tissn
•917
Brine










IZFOSD1B BOOT!
Ineastion
Initiation










lUlRicu
9ETHC9
OF 1C











»5BBES
OF CUBS
al •
« 2










EJIGI
a) tot glwem
b) 0.01-0.33 ng/nl










""
a) 0.200 t or - 0.007
aiol/kg
b) lot oiTea









GBItm n-OMHXtW
al 28 he «rcr*tions alter 0.3S8
nrl/kq oral dose of i-irlen«. Peak
IB 1-3 »r
t) Painters. Estiaatea froi graph.
IJnnal rarittlet.

(olinteers, *eaa age S3 re (oral) and
32 fr (spray painters) .

iBiit; annciiTES: OCCTPITIOIIL
EITISBS; TO?DUTIO> BIPOSUB!; BITBTI
IC»IS; Fi ! laKOS
SBTEKICI
Ogata, B.
Taaazaki, I.
Saaihara, E.
Shiaada. I.
KoyvfOf 7*
199(1
International archives
of occupational anj
Invironkeatal Bealth
•6:127-139


-------
   «ae  ft CI|
          (9 cii
»!-T3-S
C«-BS
•I tlC.2. n -1.IC, IP 112 C, W  10 U •• at  58.5  C
iissie

uw
tceath










«019
Breath












MMSOM MITI



























alURICtl
IRIOD
CC/BS











sc-ss













I-DBBEB
or cisss
s











M (Ml
naples)












MM!

lot 
-------
ladlaa
In
It* 1U.7C, t* 1SC.C1 C, 3P 20(0 C
                                                                                     (COIIIIOBD)
IISSOE



«02f
Brill





















•022
Mart



















•023
Eidaer

















IXMSOIB SOU


































































IMtTTICU
BETHOD


U






















u




















1


















mtn*
or cisis

























*> «
b» 2



















) 7
» 2

















IIIGI



«) fat glrm
b) tone detected
c) lot alten
d) lot firen



















«} tfot gives
b) lane detected



















I lot given
i lone detected

















»S»B | GZBIUl IirOBBlTIOI
1
I
1
a) 9.OJ « or - O.fl« | et irt | •) «ale*
(1«ll«n) | t) resales
b) lose detected I
1 Icoa a «roep of *1 autopsies.
I (oreaslc aedieal ezailnations, Japan.
I tales, aean aoe 40.4 re. resales.
I aeaa aoa 37.* re.
1
I TIICE E1ER1ITS; lUTOfSIIS: J1P1I;
1 iiDnrai: iismc: ciDBiira: COBU.T:
I CEBOUIB1: COIFZR; 1BOM; BIBCB8T;
I iiciis; siGHisnru; UHGIIZSE;
1 EOBIDHHJ ini!fOIT; SClIDIOTi
1 SlinUMi (TTtllOa; TtJtDIOS; ZIIC;
1 GC10; B10BI1I; LIT1B; (30BZTS;
1 CIBmOI; CIIEBEUgil; B!»1T; BOSCLIS;
1 PlICBtlS; SPlEIi; lUKS: 1OBT1;
f BETais; coiipasann EriLnirioss; sii;
1 FCBEIStC B'DICIII
t
1
t 0.93 * or - 0.06 I a) tales
g/g (vet «t) 1 t) Feule*
) ton* detected I
1 fios a Troop of 61 antopsies.
1 forensic •edical eiaalnatioas, Japan.
1 Bales, nan aqe ««. 6 rr. resales.
1 seen aqe 37.* re*
1
I iiaci ELEdins: ioTopsi»s: Jisu;
i iinBZfoi; lESEfic: CIDKOH: COBILT:
r CHBosni: cctPiRi IBO»: BEBCOBT;
1 1IEIOB: RaGilSIDIi BalGaiESE;
1 BDEIDIM: 1III90II: SCalOIIi:
i stums; nnnm: ntmns ?i»c;
1 BCtD; 3SOB1I!; I1TCT; KIBIXTS;
1 CISIMdS; CESIEELHIKi BtlST; ROSCIES;
1 PiiCBEis; SFISI»: mss: IOBTI:
1 BIT USt COOPIE1TITE ITllniTICHS: S!I;
1 rcizisic Bieicim
BTTEBBICB



Tatara, 1.
Sazaki-Tasnaoto, B.
Isaoo. K.
Tecal. B.
i»ao
trchiTes of
EiTlrotBental a«alti
35 (1) : 36-an















Takasa, Jl.
soztlii-Tamioto, g.
Isaac, K.
Tecal, (1.
19SO
irchlres of
tnrlronaeotal Health
35<1)s 36-0













'okava, 9.
Saiafci-Iasaaoto, a.
Isaao, K.
Teral, R.
980
rchlTes of
nrironaestal Health
S(T):36-M











(•BIT fa«C)
-------
7«0-7«-S
lit 11*.?(. 0 156,61 C. BP 2080 C
                                                                                      (COITIVIBD)
HSSDE



»02«
line


















«02S




















*026
BiBda


















ZPOSOM 1OOTI
































































ininicit
BETROD


a



















M




















U



















Brain
or cists


11
3


















al 2
bl 2



















a) «
M «


















inei



0.13 «j/9 (KM ft}
0.005 mo/9 («at «t|


















a) Bot 9Lv«n
b) Bon lataetaa



















a) Bat ait«
b) Bat fltan


















SEIB | OZIIttl XffOHiTIOB
1
1 -
1
) 0.03 t or - 0.0* I •) Bilas
9/9 fvat vt) 1 t) YavaLai
1 0.00* vg/9 »at rt t
Badiaa) | ?roa a araii of 61 aatopslaa.
1 total lie Mdleal araalnatloaa, Japan.
1 Balw. nil aqe *0.6 rr. (••ales.
1 Mas aq« 37.* re.
1 THICI tiRBiitS: lottusies: JIPII:
1 llOBIBm; 1BSEBIC; C1DBXITB; COBll*;
l cnoEin; corpEB; iBoi: BEKOBT:
1 tBinfl: "WiESina: BueiBESE:
1 BBBioxra; amson; scairemi;
I !ItE»TBlJ TIlaBIOB: nBIDTOB: ZIBC;
| 6CLD: SBoniZ; LITtB; KIBfllS;
| CttEB»m; CHffllLWRt HEIMJ BOSCltS-.
I tiBCBits; sritiBi toias: icni:
| BtTalS: COBtlBallTB BTalgiTIOBS; SEX;
I IOSIISIC BIB KIBE
1
1
at 0.07 « oc - 0.10 | a) Balas
B9/9 (vat vt) | \) Vaaalav
)| Bon* tetacttd 1
1 Ito» a qcoap of tl latopalai.
I fcraaslc aaalcal •laaioatloai, Japai.
I (alas, aaaa 14* »O.S rr. males.
1 i«ai &9« 37.1 Tr.
1
| tllCt Il*Bt«S: IBtOPSIES; JaPIBt
l itoBini: iBssiic: CIOBIDB; COBU.T:
t CnOHIOBi CCPFBB; tlOB; HEBCUSI;
l lit JOB; ai«BESV»: BIIGIIESE:
| J5BIOW1J IBTIBOBT: SCUDIOBl
I snniBB: TiniinB! nuDioa: znc;
I GciB: BBOaiBt: UTEI; BTDBITS;
f ciBEBRira: CIBESEUOB: BUBI; BOSCIBSS
1 IIICIE1S: SI1BBB; tOBSS: lOBTit
l amis; coflniiTiTE ETU.OITIOIS: SM-,
1 ICItBSIC BBtlCIWS
1
1
a) Bat aatactad t a) Balat
b) 0.02 * or - .0* | t) r«ial««
aq/4 (vat vt) |
1 Froi a O.EOIT of 61 iitop*ia«.
1 (oraislc ia4ieal •laainatloa*. Japai.
1 BtlM, Mia 19* *0. 6 ir. Taaala*,
1 l«a« aqa 37.* Tr.
1
l mci iLBiiits; mopsiss: JUIB:
1 atHBtni; 1BSEBIC; C1D8HJB; COBUTi
1 CB1CBTOB; CCPPiB) IBOB; BMCVBt:
1 11C1OT; BlSBISHIBi BII61BMB;
1 1BBIOIIIB: tlTIIOBtJ SCIBDIVB;
1 siirirafl: TKiitoii TIBUIOB: irtc:
1 «015: KOHni; im«; KIOiIIS;
1 CtlEBtUl; CHZBXILOB: BEaBTJ BUSCLBS;
1 t»C9EU! stinij inias; IOBTI;
1 BITUS; COBPUlTin ETallHtlCBS: SEX;
1 ictnsic nciciBi
1
UIZ1IBCI



Tafcana, B.
Sazokl-Tanaoto, a.
liaao. It.
Tacal. B.
1990
ircklfea of
inriroacantal Baaltk
( l»3 «»












Tnltava* H.
Satakl-Iaaaaoto. B.
laaao, I.
Taral, B.
I960
irohirai of
EnflroBBBital Ha«lt»
3Sf 11 136-4*













Tvkava. B.
Svnkl-Timaota. 
-------
   7««fl-7a-6
   III
   Itl 1K.76.  IP 156.61 C.  BF 2080 C
                                                                                         (COBTIR0ED)
IISSOE


»027
Pancreas


















•028
spleen

















EIPOSOBE BOOT









































liaiTTICAl
RETHOD

11



















11


















BOBBIE
OF CISSS

a) S
b) 2


















a) 5
b) 3

















Si BSE


a) lot given
b) Bot given


















a) lot given
b) lot given

















BEAR | GEEtBAL IEFOSR1TXOB
1
I
a) 0.01 + or - 0.01 I a) Bales
ug/g (vet vt) I t| Fenales
b) 0.002 ag/g vet vt I
(aedian) I from a group of 61 autopsies.
I forensic aedlcal exaainatioas. Japan.
j Bales, aean age »0. 6 vr. Fenales.
I neaa age 37.* yr.
1
| 1P.1CE EISBSBTS: AUTOPSIES; JAPAB;
| AlOBIRVR; 1BSEBIC: CADRIDB; COBILT;
I CBBCRIVR: COPPEB; IBOf; BEBCaBT;
| IICIBB; RIGBESIUR; RABGAEESE;
1 SOBIDIUR: 1BTIROBT; SC1BDIDB;
I jiLEiim: TITIBIOR; WRADIBB: ZIBC;
| GCID: BROHIREJ 1ITES; KIDBETS;
I CIBEBBUR; CE8EBE1I8B; HEIST; RUSCLES;
I PIBCSEtS; SPIEEB; LUEGS; AOBTA:
| BFTUS; CORPABATXTE STALHATIOES; SET;
| 10BEBSIC REDICIBE
1
a) 0.01 « or - 0.01 | a) Rales
ag/g (vet vt) | t) Pennies
b) 0.03 * or - 0.03 I
ag/g (vet vt) 1 Frov a grosp of SI autopsies.
1 forensic •epical ezaslnations, Japan.
I Bales, nean age 40. 6 yr. Fenales,
I scan age 37.* vr.
1
I IBACB ELEBERTS; AUTOPSIES; J1P1B;
I 1IBEIE1R; IBSEBIC; CIDSIOH; COBUT;
| CEBCHni: CCPPEB; IBOI: HEBCOBT;
I IVBIOR; BISRESIOB; RIBGIBESE;
I BQStDTIlI; 1BTIBOBT; SC1BSTDR;
1 SIlIBIUd; TIUBIOM; VlBiDIOB; ZIVC;
I GC1B; BSORIBt; LITEB; KIDIETS:
| CIBIBBIS; CIBEBElLItH: HBMT; MtJSCllS;
| P1BCBE1S; SPIEEB; IOBGS; aOBTt:
I RIT1LS; COHPIStTITE ETlttUIIOIS; SEI;
I IC8EBSIC BBDICIBE I
BEFEBEBCS


Tokava. fli
Saznki-Iasaaoto, a.
Inano, K.
Terai. B.
1980
archives of
Environmental Health
35(1):36-«»












Takava, R.
SaTOki-Iasoaoto, B.
aaaao, K.
Terai. B.
1980
archives of
Environmental Health
35(1):3«-««











ledine
7553-56-2
I
Itv 126.90«S, HP 113.60 C. BP  185.2* C,  TP (solid)  0.03 aa Bg at 0 C. 0.305 an Bg at 25 C, 2.151  a*  Bg  at SO C,  2C.T« mm Bg at 90 C
TISSUE
•029
Rair

















EIPOSOBE BOOTE


















1
IMLTTICit
RETHOD



















BUBBSB
OF CASES


















1
BUGS


















1
sei*



















GEREBil IBFOBBITIOB
Beviev. 2* cepresentative
pie-analysis treatments are
tatalate*. The feasibility of a
be list ic, no-vash policy for hair
analysis is cutlinei an! sapcorted.
EtTIIB; TBACt EIERSBTS; RAIB;
• OSIBatll: RUSDBEREBT 1ETBODS;
ftTlLS; PBOTZIBS; COBP1BJTIT!
IT»101TIO«S; ILORIBTR; 1BTIBCBT;
aBSEBIC; BHHIU3: BRONB!; CiDBIUB;
CI1CN9; CBICEIBE; CHBONIUH: COEILT:
CCPPEB: sail inn: Grsiisinn; soio;
ICDIIE: tpoi: LIITHASIS: IZ»D:
RisBESiaR: RinaaRESE; REBcniT:
BOITBDEIOH: HCKEL: PROSPBOBOS;
PCTtSSIIB: BOBID11B: SEtEBIOR;
SIIICO«: SILTEP; SODI1": STBOBTIOR;
seiftnt: Tils TiriittiiR: TOBOMER;
*
BXFESZBCE
Chittlebomigh. G.
1980
Science of the Total
Environment 1«:53-7S















                                                                                       (HIT PIG!)
-------
:«J-S6-2
tt 126.9045, IP 113.60 C, 91 1*5.2* C, TP [oolld) 0.03 •• Kg at 0 C, 0.30S •• flg tt 25 C, 2.154 aa Sg tt 50 C, 26.71 aa Rg tt 90 c
TX3SVS


4030
lair
















4031
Balr








Eitasora >oni





























IMtRIClt
BXTBOB


11

















n








ROB an
OT CkSIS


a) 19
W 15
c) 17
•) 12
f) 5














a) 42
b) 40








B1BGI


a) lot glT«a
b) lot giTCB
c) lot glTaa
4) lot giv«B
•) lot gi»an
*) lot givan














a) 0.059-1.055 «g/g
b) 0.015-15.167 og/g








Silt \ 61III1L IirORBlTXOf
1
1
1
a) 19.0 * or - 5.1 1 «1 Coatrola, at birth
og/g | bl Fnll-tara lo» birth wight, at
bt 110.0 » or - 44 | tlrth
og/g | «) fra-tara, at birth
c) 110.0 * or - 49.2 I 4) Coitrola, 1 BO
ng/g | a) Fall-tarB lov birthvaigfat* 1 ao
0) 28.5 » or - 26.1 1 I) Pwtara. 1 ao
og/o; I lailtis * or - SK
a1 112.5 + or - 44.1 |
ag/g i laaaataa in Balifai. pra-tara group
«) 575.0 » or - 113.2 I MM bicthaaight 181« g, 26-36 »lt
ag/g | gaatatioB. foil-tan lo* blrthwaight
I gtoap tean blrtk valght 2371 g, 39-42
i »* gestation, ant fall-tera controls
j aaaa birtkvalght 3590 g, 38-42 n)t
1
1 BUB: RKits: ziic: COPPIB;
I Biieuist: TIUDIUH: IODIBE: nnirs;
I s«x
I
a) 0.422 ag/g t t) Controls
b) 0.143 ag/g | b) Raltlpla celaroals pttlaata
Railans I Staples fcoa 7 scalp altaa IB «ach
1 iab]aet.
1
1 Cllllla; ICTUS; CERTMl USTOtJS
1 !1S11lth Tarioos raaal Uaaaaas,
tafora 41alfaia

ChlUraa, 5.5-18 rr
iioiEscERs; cnioan; Kititn
tlSUSK-. B1OOD: QBln; HIUOEIH.TS1S;
lUSDlHEn RRRODS; I10B; HRUS
1ERBZICC

Tnkava, R.
Siizaki-Taaaaoto, B.
laano, R.
Taral, B.
1980
Itchivas of
Eivironaaatal Raalth
35 (lit 36-44










Ellis, D.
1979
Clinical Cheaiatcr
25 Pit 74 1-744



                                                                                       flER P1SE>
-------
atl 55.8*7, se 1535 c (para).  1000-1300 C  (east).  1SOO  C  (nought).  1300 C (steel) ,  B» 3000 C.  T* 1 u Bg at 1787 c.
                                                                                      (COBflBttBS)
                                                                                                                       10  ••  «g  «t  20*0 c
1ISSBB
•03*
ElOOd.
serua
1035
Blood,
sens
•036
lood.
Sana
«037
BodT
EirosBBi BOBT
ingest ioa


gestion
1U1RIC11
antes
us


dioaetry
•OBBBI
OF casis
al 26
bl 2S
c) 25
4) 20
10
*
(
g
25
12
| S1IGB
*) lot gl**>
b) lot gi*ea
c) lot give*
d) lot give a
•) «-18 OBOlaS/1
b) 3-15 aaoles/1
212-237 «g/dl
0.2-2. 8V of doss
0.6-1.5* of dose
0.4-12. rt of lose
1.2-8.51 of dose
nil I etttui iBToBBitroB t BEFEBIBCB
1 i
i i
a) 88 « or - 37 I •) Breast >llk OBIT 1 Picclano, B.F.
ag/100 ml | t) Fe-fortizied foraola (1* sg/gt) to 1 Deer ing. B.B.
b) 75 » or - 2« | * 10 I 1980
•4/100 ml | c) to-fortified foc»la (1« «g/qt) to I tnrlcu Journal of
O 9» « or - «3 | 12 «o | Clinical In tr it ion
ag/100 al 1 d) Ioa-tortift*d focaula (1.* ig/gt) I 33:7*6-753
1) 60 * or - 29 | tc » ao (differed sianificaatlr) 1
ag/100 al I * traasfacria satacation of fe) and d) 1
I •loalficaatlT lover. Data available I
I fer ages 3 and 9 ao. 1
1 1
| Full-tera 5.5-6.0 kg iafaata in 1
| Illinois 1
| le Set ieieacT la 2 cases. I
1 1
1 isoi: DIETS: niBoii: luiiois: BIOOD i
| SZBVR; COHP111TITE ETJI01TIOIS; I
| I1CI1TIOI 1
1 '
a) 11.5 aaoles/1 I a) Subjects aith noraal s«rua 1 Watson, v.s.
b) 9.5 uaoles/1 1 ferritin 1 Rone, B.
j b) Sablects sitk sabaoraal serua I Boore, B.B.
I f«rritia I 1980
I I tancet 2(8118) :236-237
1 35-70 jr alia. United Ungdoa. 9 I
| patients vith chronic blood loss* I
1 besipatesis, or i«nes»ctio» for 1
j secoadarT polrcythenia* 1 nornal |
| klcod iooor. I
1 1
1 DiiTED msoca: BLOOD SIBVB; BOUT; i
| BIOlCCOjnilTIOE; HETIBOLISB; IB TITO 1
I imrsis; IBCI; IEID i
1 1
221 ug/dl 1 Ittkritis patieats vita possibl* iron I B'Seffar, 1.
1 ttorage disease. j ronasier, T.L.
1 | rox. I.B.
| 38-!> rr old Canadians I 1977
1 f Journal of the iaerican
1 Jcint pain, cltrated transferrla I Hedical lasociation
I allocation, aneaia, deer east d libido, I 238 (17) : 1825-1828
1 iipoteace. i
1 1
1 reposition of heansiderin IB 1
1 lepatocrtes IB all, cirrhosis in one. 1
1 1
1 EIOOD s*Bna: itoi: CIHDI; icniTS; i
| SITUS: BETH POISOII1S 1
i i
1 1
> 0.71 of dose I a) ferric ortnophosphate 1 Bios, E.
1.0* of dose j b) Sod la a irca pyropbosphate j Hanter, B.E.
2.7% of dosa | e) Ferrous sulfate 1 Cook, J.D.
a.o* of dose 1 d) Bedaced iron, 5-10 u particle size 1 Saith, l.j.
s«oa«trie I t* suppleaeit foras IB a)-d) 1 Finch, C.I.
I « hole- bod T attake 10 days after last I 1975
I of flv« 10 g feedings of cereal 1 Pediatrics
I containing 5 *g P«- label led dose. 1 55 (5) :686-«93
1 Cata for other iroa nnpleaeats. 1
1 1
I 1-7 aoaths elds, lov socioeconoaic 1
I class, siailar iron nutrition. I
1 1
I ISOI; IMltS; DIFtS: CO<1Plt*tITt 1
1 TtimiTioiiS: urirts; BOOT: EBDGS; I
| IKCt EIBHEIIS |
1 1
tiBtt MSB)
                                                                                                                                                                                           oo
-------
lit*
7«9-89-6
It
Itl 35.9*7,
            0  IBS c  (pint,
                              tMO-1300 C (cut), 1500 C (troagkt). 1300 C lc >*4ieal aiMlaatiODi. Japaa.
j (»«t irt) I Halts, M«i aq» »0. « yr. ?«al«,
1 I •*» a9* 11. » TT.
1 <
I t met zuniTSi inomss; J»PII:
I t auniWi iismc; ciBBUjB: COBU.T:
I i cttoimis; COEPZB: IMC BIBCOTI;
1 i mm: itsitsniB: iiieiiist:
i i loeiDimi: imnon: sctnini:
1 i SHUTS!; Tiiunai; mtviaa: »K:
| | SC1D; nOBIIl; IITHS KIDfFTS;
1 \ cniBitM: cuamm; BUST; gosciis;
I i fiicitis; spine inras; IOITI:
1 | BITllS; COHPlMtm BTiiniTICIS; SBI:
1 i retnsie IIDICIH
1 1
a) lot giv« | a) 13.9 * ot - 1.1 t a) Global paUltos. 11 saiplcs,
b) lot 9iT«m | ••oVg 1 cMffleliBt of variation (C») 2C.6«
e) lot «i»«a I b) 12.8 * or - 0.7 I b) Camlat* n«cl««s, 11 maptes, CT
i) lot ji»am | aaol/4 1 11. *«
•} lot git«» | el 10.9 t 01 - 1.2 Icl tataaaa, 12 »a»plas. CT 38.81
IJ lot givaa I uol/g I i) Sabataatia ni^ra, « aaaplea, CT
1 1) 19.1 * or - 2.1 1 21.2V
1 aaol/g | c) Carabral cort«i, 16 *aapl«. CT
la) «.» » 01 - 0.» I 3i.«
1 aaoV9 1 I) llppocaapM. 8 saaplas, CT 26. »*
1 fl 2.6 t or - 0.3 1
1 aaol/4 1 titopiT Mipln
1 Dry «t |
1 ss i cttmu COITXI: iBtsomm BITSOPS;
t i ciicwi: ccptiij IBOI; MICKCSB;
1 | (Bill; lUTCfSIIS
1 1
•ot giT«a | 166.0 ag I C 1 «aapl«a at cat* of 1 !/•!•. 2-10
1 | »i» aCtcc taralai a arc *«UiB4 cods.
1 1
1 1 DalwsltT pVrsicB «kop, nocida
1 1
1 I fiotisa; HOLTS : BBHTB; ciictna;
1 1 CE101IIBJ CH9OHIOS: COVPBI: ISOI;
I i ttiB; uieiiisK: ncm,: potissiust
I t snrn: TITIITBH; TIBIOIOI; n«c; lit
1 1 fCILOTIOl; PMES: 1»SOSTSI»I
1 t ItBOSPBHES; TB1C1 ZIEIEVTS
1 1
1 1
a) lot givaa I a) 23 ppa I a) laanlaq 41nbl««
b) lot givaa 1 b) 22 ppa I t) Coatrols
1 1
1 1 t«»t»lm
-------
lioo
1MV89-C
»^ jy—»y w
it
U« SS.ga?. B* 1535 c (pit*), 1000-1300 C  (cast), 1500 C  (trtn^at). 1300 c (steel), B» 3000 C,  T? 1  » 19  at  1787  C,  10 •• agj
                                                                                    (coiiiioca)
•t 20*0 c
tISSO!

*0*2
lair




















«0«3
Heart

















*OM
Kidney


















SIPOStJBJ BOO






























































immcu.
SKIOC






















n


















n



















BOB BBS
or CASZS






















a) 8
W 3

















a) 16
> 3


















tIBCB























a) J.»-68 a«/« (net rt)
1) 19-73 19/9 l«t »tl

















6. 6-1(0 «9/9 (net it)
37-130 gg/g (mt vt)


















BBIB 1 fiEHBU. IBTQxBlTlOI
1
| Bavlen. 24 represeatatim
1 tre-analTais treataaats are
I tabelatel. The fcasibilitT of a
I Bdllstic. eo-iash policy for hair
I »ajysls is outlined anl support**.
1
| UllZt; TBJCt nitHRS; BUS;
1 USTBU.H: BIISOBIBBB* IBTBODS;
i KttLS; noTinsi ccwmtift
| IfUDlTIOIS; ILBBtlUI; 1RIBOIT;
1 itsmc: tuna: BHOBIIBI C»BBIOS;
t ciiciaj; csiciiH: cssomas: conn;
1 CCF*R; auini; cts«iiir»: eoio:
t ICDIIB; 1ROB: lliTHITOB; IBIB:
I MfiBMlfl; MIMIBSB; BgECtlBT;
| KITBDtmi: BICCZl; PBOSPHOBW;
I foTission; tmazii; sncnoR;
I SI1ICO1; SIItBB; SOBIOB; STBOTIOB;
1 SOITOti TIB: TITtnOB: TOICSTCB;
1 TIBC; ZItCO»JBB
1
t
a) 38 » or - 20 «j/g | a) Rales
(•at *t) | t) Feaalea
b) a* * or - 27 ag/9 j
(vet *t) 1 Itaa a 
-------
 Irei  .
 7«3 *-**-«
1C
Itl 55.a«7, IP 1535 C (pore), 1000-1300 c (east),  1500 C  fumaht).  1300 c (itecll, tr 3900 C. n 1
                                                                                                        *9 at 1787 C.  10 u Hg it Z0«0 C
1IS30I


4045
Kidney






















>04t
liver



















a 047
liver



















tOSOBS BOni




































































1BJIRIC11
imoi

























Ba




















u




















mesa
r cists

a
a
12





















) 3
b> 5



















a) 8
b) 9
C) 11


















IIB6I | Bill | 6EBIE11 IBMBS1TI01
1 1

51-148 og/g
40-513 og/g
27- 507 ««/?
•t vt




















a) 29-150 ig/g («et at)
b) 44-2*0 ag/g (vet vt)



















a) 81-391 ug/g
b) 111-796 ag/g
c] 91-344 io/g
Bet vt

















1
) 79 ag/g 1 a) Contrail
94 ag/g I b) torkar grcap I
54 ug/j 1 c) Writer qtcip II
et vt i
edtans 1 teceasad refinery a»d seelter
I verkers. agea 55-76 yr. exposed to
1 heavy ietala 1-3 decades. Tla«
1 tatieea retiremt aid deatk 0-1.5 jc
1 la groip I and 2—19 yr, groap II.
I Controls, ages 43-72 yr, vho lived 50
I ki froa tne factory. Sveden.
I
t SIUI*: ClBattSS; KID1ITS; liyiB;
I 10B6S: coBPaBiTiTi BTHBITIOIS;
I iBoasTniat iiftim: CTISOBEBWT
t IRBOOS; iiiiBOii; IESCTTC; c»omna;
1 cis in a; CBBOBIOB; COBILT; COPPIB;
| GOLD: IS01; UBTBMBB: tSlD;
I eifGMESI: HIBCVIT-. MtTBDXim;
1 fEOSPBOiis: BITBIDIDB: sciigitn;
I SILEVIN; SHVEB; TIB; TVBGSIEB;
1 II«C; BEI1TB B1Z1SDS; IBDHSTBI11
t ti»ns; smiTSSS; Tnivnna
i
a) 62 * or - 68 ng/g 1 a) Bales
(vet vt) 1 t) Veaalas
b) 150 + or - 83 ug/g 1
(vet vt) 1 Itoi a grc«f of 61 aotopsi«3.
I fereaaic aedical exaainatlona, Japan.
I Bales, aeaa age «0. » yr. Tesalas,
| aaan age 37.4 yr.
1
| TB1CI EIEBEB1S: 10TOPSIES: J1P1I;
1 tiBnBVB: iBsuic: cioaioB: COBILT;
1 CWCHOB; CCJSIB; isoi; BKBCDII:
| IBCIDB; SIGIISIDB; BIIGISESI;
1 JOBID10!!: IIKBOIT; SC1B9IOB;
| SIUIHJ1; TITMIOa; T1B19IQB: ZI«C:
| 6CID; IBOIfll!: tlVIB; HDIITS;
I CZlE9B>n; CIBtBEUIB; HE1BT: BDSCLBS;
I ElBClElS; SFUEI; LBISS; >O»1i:
I SITUS; COBP1B1T1YS STIHHTICKS; SII;
I fCBMSIC BIIICItE
1
1
a) 246 ag/g | a) Controls
b) , 198 ag/g | c) Vorker gtcap I
c) 139 ng/
-------
Horn
7*39-89-8

It* 55.M7.  BP 1535 C  front.  1080-1300 C (east). 1500 C (*ro*ait). 1300 C {ttaol),  »  3000 C,
n 1 n Bg «t 1187 C, 10 •• 1« at 20*0 C
1X359*



*0«t
LM«
•••"^

















•0*9
Ilia























•050
leaf














BIPOSO*! wnm






























































allLRXCU
BETBOD


a


















it























Boaabaeer















TOBBH | IUEI
or cuss i
i
I
3 1 112-280 ag/a |v«t M)
|
|

•
|
|
I
|
I
I
I
1

I

1
1
I
•18 It) 122- Kit ag/g
hj 9 | b) 80-«C8 19/4
d 11 |C) 32-»23 ag/g
I (*t M
|
|
|
|
1

|
|
I
|

1
|
I
1
1

1
1
1
1
1 a) lot glT«a
1 k) lot gi»a»
| c) (at gi»«»
1 d) lot 9iT«c
I e) lot gii«>
I f| Ht glt«n
1 g) lot gl»«
1 h| lot gl»«D
1 1) lot giwa
1
1
1
1
1
1
I
mn i GZIIUL imnnnoi
i
i
i
200 • or - It *q/g I «•!«•
(Mt *t) I
1 icot * oroip of 61 utapclcc.
1 £cr«««lc >«dlc«l •nilMtioni, Jap*n
1 !•!«, •••• 19* *0.t yr. r«ul«s.
I •••• •«• 3T.« yr.
1
i IIKI nuira: anaMiiS! JIPI»;
1 iioims: iiscvic: c»ai0B; cosnit
1 cHOBina; comi; 1101: nicni:
l utiva: iieiisim: nvemsi:
1 18110118: tMX80R{ SCIIDIOB;
1 snmira; TmiioR; T»«Binij sues
l cnir SBOMIIS iifras IIDIIIS:
I cnzsm; ninsuii8: auit: ROSCIIS;
| F1ICRI1S; SFISXI: 10«S5J JOKJ;
I iRiLS; coHmuin nkivuinsi SBI:
l fctinrc siDicifB
i

•1 303 19/9 1 *> Cootrols
k) 139 ai/g 1 fe) fotkct gtcav I
el 13* >4/g 1 c( >ork«r 9tc«» II
Mt *t I
Icdlau 1 t «••»«* rcflMrr >•< neltor
1 >otk*r>, aq*i SS-'e yr. exposed to
1 b«»Ty Mtal* 1-3 4*ead«s. Tie*
I t«tm« ntln**«t a*4 i«atk 0-1.S yr
j li gcaia I ail 2-19 yt, qroap II.
1 ccaitrols, a«a« *3-72 yr, *>o lii«4 SO
1 ki (toi tie factory. S«e4««.
1
l sitint cititBS: Knms: IITIB;
| ITJISSi COniHTIft SM1WTIOJS;
l iiDvsrnai nenn; ntsTinniT
I MtBODS: iniBoii; IBS me ; C»DKOB:
l ctsivt; citonni; COBU.T: cowsi:
1 COLE; noi: uirmoa: LZIDI
I iifeitEtt: ttncuti; aomntmis
l tcospaoiDi; tmiont: sen mm:
I 3 n mm; sitrsBi Hi; TOIGSTM;
1 TIIC; II11T8 UZUBS; I>DVSnial
t fiins; sannisi tiuoaian
i
I
I O.m | a) torial
) J. »5* | k) Beaosidtroals
) 1.0M | c) lette btoacaltia
1 0.16* Id) coalvoctcc
) 0.621 1 •) caalvork«i
I 13.5* 1 t} Boiatit* rarkar
1 1.99Y I q) TomlCT vetker
! 0.37* 1 h| coalvorlrec. Fir l»aloi
> 1.3*3 | 1) Saa* cotl«ork«r, excladlaq PIT
Feicent ixj *t 1 Itslos
1 l(aiarm«ta corraetad foi 4ist
1 coitait.
(
I vinio niGCCTi i9TR,n; nn«:
I KUSflinSIT BETHOTS.- I§0»; DOST
t
smmcs



Tak»a> B.
Sazqki-Ianaoto, «.
laaao, K.
Tacal. a.
1980
Iiekiva* of
UTiroaaoital Haaltk
35M):36-M












Braaa, D.
lordbacg, 6.
lastar, P.O.
1980
Scincf of tbe Total
Intitoaaent 16:13-35



















GDest, 1.
197«
laaala of Occapatloaal
Hygione 19:49-62












(KIT P16E)
                                                                                                                                                                                      N)
-------
 Iroi
7t39-»9-<
F«
It* 55.B4T,
            BP 1535 C (pin), 1000-1300 C (cut).  1500 C (ixoigit), 1300 C (steel), BP 3000 C, TP 1 •• Bg at 1787 C.  10  ••  Eg at 20*0 C
1ISSBI
40S1
Bncle
ton
taicnai
4053
SBllal
earl
MPOS018 MKI



1BIITTIC1I
SET «00
11
»
I-ray spectral
IOBBE8
or cisss
•> *
*> 3
«1 5
b) 3
•» 7
tj 12
Slid
) 11-54 n/9 (Mt •*)
) 1fr-»7 ««/« l««t *t)
«.) 12-48 «V9 <«*t «tl
b) 1S-67 »g/g («*t lit)
•) 28.»-1B1.5 »g/g
b) 24.0-122.5 ig/g
DtT *t
nn i Giniii MratMTioB
i
i
) 26 » or - 20 09/9 I i) Riles
|»»t »t) | t| nnlci
b) 27 * or - 17 19/9 I
««t »t) j Iroi • gtalp of «1 aitopllvi,
1 foMnie Mdieit oz*il»tiau, JapaB.
1 Btl«a, mi *q« 40. « Tr. T«Mln.
1 •«*• «g» 37.4 ft.
1
I T1ICI 11EBIKS; HTTOPJI1S: J1P1I;
1 tunng; nsnic; ciomtia: COBUT;
I cnogivR; come 1*0*: IEICUBT;
1 iieni: iiensiiM: iiieiitss;
1 Mturn; imaoR; SCHIHOH-.
| SH.HIOS; TITillOl! T1I1DIDS: ZIK:
1 eott: Bsoiiii; tun: ntins;
1 ctustTM: cisraeum: HSiM; ausciss;
1 PMCII1S; SHIER: 10«S; lOITli
I SITUS; COIPlllIITt OT110HIOS; SSI;
1 1C1MS1C B»K»«
1
a) 32 • or - 17 ag/9 I at flalvs
<»«t it) t I) r*aal«*
b) 47 t or - 28 ag/« t
tnt «t) | Iroa a groip el 61 aatopslec,
j teiamslc ••
-------
  Itoa
  7*39-89-6
  T«
  lt» S5.8»7,  IP 1535 C (pore), 1009-1300 C  (cast),  1500  C (noaght), 1300 C (ctMl) , B* 3040 C,  TP  1  ai  19 at 1787 C.  10 aa Kg at 20*0 C
iissm
*os*
SpleeB
















EXVOSISI tan*


















nitnicu
n

















Of USES
a| 5
B) 3
















mot
a) 57-«10 «g/g (net rt)
fc| 150-590 09/9 {vet vt)
















BZ»P
a) 369 * or - 1*0
og/9 («at «t»
b) 3*0 » ot - 330
a9/9 (»«t vt)














GZIZ111 MTOBB1TXOB
a) Bales
l| Teaales

fro> a group of 61 antopoie«.
forensic aeiieal examinations, Japan.
Gales, aean eoe *0*6 vr. Feaalea,
tean age 37.* jr.
imcj zizvzits: JOTOPSIZSJ ji»»»:
llORXBOB; 1B5Z11C: C&SBIUB: COZILT^
CnCBtOB; COmii IBOI; 5UC13HT:
Konn; Bisiisius; BHGMZSB;
•OfZDIOH; JVTZBOR; SCAmoB;
stinna; muian; TIIUIOB: z»c;
eciD; BioBiiz; iitzu: KIDXZTS;
CtBIBHIl; CZiZBIlIOB: BUST; B03CLES:
FMCtllS; SPIIEf i 1VKS; JOBT1:
9II11S; COD7IMTITK ZT»10»TIO»S ; SEI;
TCIZISIC B»ICX»
nnazBcz
Titkava, B.
SBinki-Tamaoto, a.
1KB9, K.
Teral, a.
USD

XBYiroiiMBttl Dealtb
35(1}:3«-M










Itobttrl tlcckol  (« CI(
t-Prapanol. 2-ntkrl-  (9 CIJ
   7*. 12. BP 107.40 C. TP  10 aa 89  at  21.7 C
iissnz

•055
Breata










•056
Ecaath












ztPosoiE xonz


























1U1RIC11
BZTBCD
oc/as











sons












IDBBEB
or CISKS
8











5* (387
saaplesl












Eiies

lot detect «S-3 1.0 ag/hr











lot glrea












izii 	

10. « ag/hr











0.328 09/1
Seoaetric












Gtllnt IWTCSHtlOt

ccacand related to earaal
xtibotia*. lo otter detail! gireB
CryogeBic flaapliag techBl9ve.

BcaltkT ailltarr a>4 civilian
caeloreea. O.S. llr Force School of
Jcroapace leiiclcv, aoes 23->7 jrt. 3
EtoIierB.
CtlZnZS; CBIOIIIITED BTBBOCISBOS;
cBtopiir* of sine coaponos;
cfiosomzzizs; rnomn COBPOOIDS;
UllTB; I1CC80LS; THIS; 1DTCTS
tcatarel at 25 C aad 760 » 89
13. tl occirreBce
lever aad aff«r oae-sigaa Halts
0.06A and 1.19 ig/1

B«altar, 18-35 rr old, aonsMkivg,
artaa blacks aai Caucasians.
Ckicaqo. 11. SlqldlT cootcollea
•xpariaental eoilitiois.
IltlTI; alCCBOlS; I1UIOIS; « DOLTS;
cnonitTZE insociiBois; >OII*ILI
cieanc coBfcuins: BZUTB BIXUBS;
lIBtliTTCI; ESTtEOLISB: HMIEOLITES;
fCPJUTIOJ IIPOSOW; tJBBU 1BZ1S
SE»B«Z»C«

COBkle, J.p.
Caap, B.J.
Velek. B.C.
1975
IrcLiTes of
far! ronaeutal Health
30 f 2) ; 2*0-295





Krotoazjxaki, B.K.
Bronean, S. B.
C'leill. H.J.
1979
Journal of laalrtical
ToiiiologT 3:225-23*








-------
iiooctrl alcokol  it at
Icooctaaal  (9 CI|
2C*52-21'6
C6-B18-0
«« 130.22
1ISSB1
• 057
Bnatk











EIMSOtS BOOT!













iBaiTtxcja
BETHOO
SC-BS












(OIBZB
or cists
54 [387
suplea)











BUGS
lot given












Bill
1.3 n«/l
SeoMtrie











eiBiBit irroBBinoi
leagued it 25 C and 760 la Bq
1!.IK occurrence
loner and «pper o«-Slq*a limits 0.33
aid 5.1 n«/l

Bealthr. 18-35 rr old. nonanokliq.
urban Hacks ud Caucasians.
Cklcaqo. 11. BlqWlT controlled
EStlTB; UCCEOlSj I1HBOIS: 1DHIT3;
CnOBItllEE BTDBOCtSBOBS; TOL1TXL1
CSGIIIC COSSCTJJB5; BC1LTH HatUtS;
IBBU1TIOB; BETIMIISS; BETlBOltTBS;
PCP811TIOI EIPOSBREt IBBM »EE»S
lERUBCE
Krotanfnskl, B. K,
BrQiiejaii. Gf I.
O'J.ill, B.J.
W79
Journal of analytical
Toxicology 3:225-234







 I*op«itTl «lcohol (B CI)
 1-ettaaol, a-Mtkrl- (» CI|
 113-51-1
 C5-B12-0
 II 88.15, BP -117.2 C. S»  132 C. TP 1 M eg at W.O c
lissnt



•058









'

•05*
areatk













EIIOSOBB BOatl






























aBU/nidl
BWBOD


sc/as











ec-Bs














BOBBSS
OF CUES


8










..
5» (387














B1BGE



Bot detected-2.6 og/ir











Bot firei














Bill



0.3 J9/hr











0.182 aq/1
Geoaetrlc













GEIZBlL ISTOBB1TIOB



Ccatoand related to normal
•etabollsi. lo other detail! tjiren
Ctyoqenic aaaplLno tecnni^ive.

Bealtk7 illltary and clrillan
oployees. 0*3. ale TOEC« Sckool of
l«roapac« Badlciae, ages 23-47 yr. 3
nokera.
IinEBlS; CBlOtlBlTEC BTDSOC1BBOBS;
CtLOHBC 08GUIC COBPOOTOS;
CBLCBOBBftZftS; nnOBKE COBPOOTOSj
HIHB! IICCBOIS; TITaSi IDBITS
Ceamred at 25 c and 760 am Bq
29.11 occurrence
lover and mpper one-si?**. Unite
C.942 aad 0.781 no/1

BealtkT. 18-35 yr old. nonscoklnq.
iclan blacks and caacailana.
Cklcaao. 11. Biqldly controlled
eiperliental conditions.
EB1HH-. alCCBOLS; IUI10IS; 1DOLTS:
CElOBIBltED ByOBOCaBBOIS; TOlltllE
eceinc coBScnrgs: BEJITH mutest
IBHIUTtOt; BETITOLISB; HBTlKltlTBS:
tCPUll'IOi EIPOSOBS: OBB1B atEaS
1
BETESEICZ |
1
1
1
Conkle, a.t. I
Caap, B.J.
Velck, B.C.
1975
arehlrea of
environmental Bealth
30 (2): 290-295





KtotonTBrtl. B.K.
Bronean. G. fl.
0> Belli, B.J.
1979
Joncnal of Inalytlcal
Toxicology 3:225-23*









-------
   1.3->lt*4UM. 2-MtkTl- (9 CI)
  7I-T9-5
  C«-I8
  H Ca.11, IP -1*6.1 C. BP 3* C, T» «00 •• (9 at IS.* C
ussai
aMO
Enatk
«0«1
BTMtk

•062
Brmta
1
1 1
1 1
MPOS01S BOOT!





i ttunxcu
I BTTBOB
OC/IS
«C/BS

GOBS

IDBB»
or CISBS
"


5* (3«7
saaplul

1IIG1
0.09-0. «5 ft*
lot dcteetad- 390.0 »q/ar

lot give*

•Ell
0.23 pp*
129.8 as/he

28.9 *«/!
seoaetric

GBIIUI xiroiBATioi
correct* 9 for level IB Uktl«4 »ir
Maltkr adalts
S1EIEC IDUIISJ BEaSminBT BREO9S:
CCBpovBd c«lat«4 to BorBal
CiTO9«Bie aaBpliaq toekniopa*.
a«althr allitarr ui ciflllan
•iploy***. D.S. lie force Sclool of
•BO tor*.
t Hints: cBioamtio BTDROCIBBOIS:
CROim OISIiTC OOIPOnOS;
CBicsoniiiirs; niioim CORPOVIDS;
ElflXB; 1ICCBOIS: IEHS; ICOTTS
t«*nr*9 «t 25 C and 760 IB Bq
7Qt occnrccnoa
Ioi«r aad apper oo«-Si9»« Halt* 1*.*
ia< 58.3 na/1
Hcaltar, 18-35 yr old, nooaaoklair,
trtaa klBClta and eaieaaitaa.
ckleaga, 11. (laidlr coBtrollvd
»tHH: Hcciots; iiLiwis: iDOt-s:
CBtOBtfHR) nOtOCllBOBS; TOIITIIE
cm tic coetcnns; BIUTB Bizurs;
IIIIIITtCI; KRABOtlSI; BR1BOLIT5S;
fOIOllTIO* EIPOSOBI; U»Ba» 1BB1S
nrsiEic:
jam»OB. B.O.
1969
Joarnal of laboratori
tad Clinical Hetaoi*
74 »«> : 9«l-96«
Cookie, J.P.
caap, B.J.
»975 *
irehirea of
tBTlronaental Bealtk
30f«;290-»S

ttotaaziulii, B.E.
O'Jeill', B!J!
1»7»
Joiraal of laaljtlcal
ToTicologr 3:225-23*
1
                                                                                                                                                                                          CT-
          alcohol (8  CD
S-Propaaol (t CI)
C3-H-0
it «o.o9,  BP -ee.s to -ss.s  C.BP eo.3 c,  t?
                                              M e« at z.« c
TISS9S
Bxattk


ixiosni ions



tuiniciL
8RBOD
ec/vs


iraBn
or CASSS
i


tlKK
lot tot«ct*d-1EO.O B«/kE

tim

38.6 ag/kr

JlSt)
6IIIU1 II7OIB1TI01
CCBFoni related to aotaal
aetabolisa. Bo otkar detaila qiT«o
(••ItkT ailltary aal ciilltat
-------
          alcohol f8 CI)
2-Propaaol {» CI)
«7-«3-0
cj-M-0
•I «9.99,  IP  -88.5 to  -89.5 C.BP 80.3 C.  ?P 10 n H« at 2.4 C
IISSO!
4064
Breath












BUOSOII BOOTH













RRHOO
ac-as












IDBBES
or casss
54 (387
saaples)












11KB
lot given












am
a. ess ng/i
eeoMtric












eiinat IIPOBSITIOB
(ea sated at 25 C and 760 •• Bg
22.2V occurrence
lever aad upper oM-Sigaa liaits
0.1 55 aad 2.76 aq/1

Realthv, 11-35 Tt old. nonsmoking.
«zraa blacks and cancasiaas.
Chicago, n. Bigidlr controlled
experiaeatal conditions.
EBCHK; UCOBOLS; IttlnOIS; (DOLTS;
CflOtXa'aTtt BTOBOCIBBOIS; TOttTItB
cismc C05PCU1DS: BBU.TB BIZIBDS:
iiaiUTiot; atriBoiis>i: arTSBOLiris;
•OC011TIO* BnOSOK; «SBM IBIaS
BHBSBICI
	
Krotosxynski, B. K.
Branean, 6.B.
O'Veill, H.J.
1979
Journal of analytical
toxicologr 3:225-234








 lactic  tcU, batrl ««t«r  (S CI)
 ttenanalc acU. 2-kydroxr-. batjl ««t«r (9 CI)
 138-22-7
 Cl-BU-03
 IB 1U.18,  n  -»3 C,  BP  188 C.  TF 0.» na 84  at 20 C
tlSSQl

»0€S
Br«4th










BIPOSOS! B001E













alllRICU.
acTROg
ec/as











BOBBn
OT C1SBS
8











BUGE

lot detected-3.4 ag/hr











BS*l

0.4 ag/hr











GIIIB1L IIFOBBaTIOB

Ccifoaad related to nornal
aetabolisa. Bo other details qivea
Crrogeaic laapling technique.

Bealthy ailitaCT and civilian
eaplovees, o.s. air force school of
lerospaee Bediciae, ages 23-47 yr. 3
aaokers.
tHIIUS; CBtOBIIHBD HTBBOC1B90HS;
CBLOBTBB OB6IBXC COBPOOUDS*
CB1CBOBBIIIBBS; FIOOBIBX COBPOUBOS;
CBtaTB; alCCBOlS; THIS; atVITS
BETIKEBC1

Conkle, J.P.
Caap, B.J.
Belch, B.E.
1975
Archives of
Bnvironaental Health
30 (2): 290-295





-------
latthaii*
7*39-31-0
la
Ht 138.306, n 920 C. -at 3«» C. TP 3230  » Hg »t  tOO  C,  3*20 « Bg at 760 C
IISSBI


40C6
Bale


















»OS7
(UMT





















«WS
line




















\
EXPOSURE BOOT




































































mtnxcu,
BCTHOD





















tl






















n






















1 OB 8X3
OF cms





















aj 8
b) 20





















a) B
1 9
cj 11




















BIKE






















•1 < 0.06620-0.00040 og/g
b) < 0.00020-0. 0«6 vg/g
•et »t




















I 0.0030-0.01* ogyg
I < 0.00020-0. 051 sg/g
1 < 0. 00070-0.02* og/g
•at vt



















BUI | GEIEXII. nTOMirXOW
1
1
1 t«*i«. 2* cepreaentatin
1 pre-aaalral* treatment* arc
I titillated. The feasibility of a
I holistic, no-«a>h policy tor talc
I malysis is cotliaed and sqpfocted.
1
I mm; TRICE BimiTS; tun;
| USIBII.I1: BIlSOBMBiT RETIODS;
| (ITILS; PSOTIIIS: COBP1B1TITE
| ZTllOitXORS; UIBIBOB; tlTIKXl;
I isswic: Bisins; iioian; CIBSIOT:
1 ciicin«: CBtoBim: cBBOsias: coeiir;
1 ccppti; c«iLHJ!t; eiigiim; GOIS;
I icDin; iBoij iinflMira; LI»:
I B1EKSIRI: IMSIIZSXi HBBCUBt;
I CCIIBIIBOI: IICKILi PBOSPBOB0S:
1 SOIISSHJB; tmiBIVi; SEtEKOM;
| SILICOtl; SHTEB: SODI5B; SIBCITIOB;
I snrn; in: IITIIIDB; tncsm:
I me; ziiccizoa
a) ttot give* 1 a) Coatcol*
b) Sot glTen 1 t) «oc*«rt, qroap* I and II
1
1 t*e*as«a cefinarr and saeltci
1 lectori, age* 55-T< rr, ex posed to
1 *«a»y Mtals 1-3 decades. Time
I t«tnea cetlteaent ani deatk 0-1.5 IT
( ia groif I a*d 2-19 rr, qro«r !!•
I CQotcoli, aa«a *3*72 rr, »io llTed 50
1 t> tco* tkc factory, snedan.
1
1 stinx; cin»»EES: Kioms: iiTii;
i miss: cofpnirtrs mmTiois;
1 IBDOSTJIll BtGXtHi TO1SOBMWT
I iMBOBS: aiTiiofi: IBSEHC; CIDIIBB;
I CIST9B; CBTCBIVII; COI1LI; COPPBS;
i eott; iBof; t.naiitiB: I!»D;
I «lI5HISf: gfSCIIBT: BOlTBOEWni;
1 IEOSPBOB5S: BOBtKoa: scaioira:
I SHZIIOl: SltfEB; TI«; TtJISSIII;
I IIITC: SUITS B121RBS; UDOSTBIII
I FURS; smnnsj tainaioa
1
> O.OOSO ag/g I a) Coatrol
) 4.00SI ilg/g 1 b| locker «ceap I
t 0.00*2 »g/g | c) Bortec groap II
at vt 1
e4iaa* 1 t«c«aa«S ref iiecy aaA SMltac
I vockacSp avel SS-T6 Tt« «zposvd to
1 teary aatals 1-3 4«ca4«3. file
1 tatMea cctlcaMit and deat* 0-1.5 yr
1 In qtoip I aid 2-19 TC, ocoap II.
t ccatrola, *q«« 13-72 rr. vfeo llwd SO
1 ki fro* t>« tactory. S««daa.
1 SlltW; OB1TKBS; KIDtEIS; U?S1;
I imas: CO»»ITITE IT»II;ITIO«S:
i ncos«iit item:; «stsng«nT
1 fiTWis; UTisom: IBS me: cisnaa;
1 CtSIflU: CBBOSIHB; COBkLI; COPVSt;
1 SCICJ ItOI; IlITBtlOII; llllj
1 IIICallSE: BIBCUBt: SOLTBDIIUS;
1 ItOSfBOtOS; (OBIITQRS SCiiOIM;
1 sutiimi: siitii; TIB; KHQSTEI;
1 I11C; 1C1H1 Bktaags; IIDOSTSIU
I mnst s»EiTE«s: TBLLTOID^
l
lEFESBllCE


Chlttleborongh, •;.
1980
Sclaica of the Total
EOTiconaeot 1«s53-7S
















Dcnoe, D.
I>ecdbec9, s.
Hester, P.O.
1980
Science of tie Total
EBTlcoaawBt 1«: 13-35

















Brnne, D.
lordberg, e.
Vester, P.O.
1930
Science of the Total
Eavlronaeat 16:13-35

















(•in net)
                                                                                                                                                                                         00
-------
ll
It* 139.906. » 920 C, BP 3*S« C, TP 3230 M Hj at «00 C,  3*20 m Sg at 760 C
                                                                                      (COITimO)
H3SH
«oc*
tang



















EICOSOIE BODTE





















Hitmen
BETEOO
Ba




















OF C1SES
a) 8
bl 9
cj 10


















BIKE
a) 0.00030-0.023 ng/g
b) 0.00030-0.17 ng/g
c| 0.0010-0.025 og/g
let *t

















BE1I
a) 0.00*0 aj/g
b) 0.011 ng/g
c) 0.011 ng/g
let vt
tedians
















GJIIBJll IIFOB1UTICI
a) Control
b) Sorter qccnp I
c) locker grenp II

Ceceaset ceflnecy aad sneltec
rackers, ages 5S-76 jt, exposed to
k«a*r aetals 1-3 decades. Tine
t«t«een letlceient and deatk 0-1.5 vr
it groan I and 2-19 TC, gcoop II.
Centrals, ages «3-72 TC, vko lived SO
*« ftoa tke factorr. Sveden.
SIEBEI; CID1TEES; KIBIEtS; LITI3;
ITTI6S; CORPlBlTXtB BT» LUITIOJ5;
BITBODS; 11TUOMI:' IBSHJIC; CIDSIOH ;
CEsnm: CBBOIIOB; COBILT; COFPEB;
GCID; noi; IlITBalUB; LEU;
!1I611ESI; RtSCOBt; HOLTBDIIOB;
tsospaoBus: praiDiut; SCIBHTOB:
sitEiiiTB: sum: til: TOIGSISI;
JliC: BialTB B1Z1BDS: lEIDSIBIal
tlins; SIEITERS; TEIIOSIDB
ESniEICE
Bctne, D.
loclbecg, G.
tester, P.O.
1980
Science' of the Total
EaTicoanent 16:13-35















 I lot given















(IEXT
8EaB I
I
») 28. » + oc - 7.6
iq/W nl
b) 27.* * oc - 8.1
aq/100 al
c) 30.0 * oc - 9.*
aq/100 il
d) 27.1 * oc - 7.*
ag/100 al











P«GE|
eilRlL IIPOBBITICS |
1
a) CIS stlftcaa
t) M CIS ayiptoas
c) SI araptoas
d) Gl aynptoaa
significant eoccelatlon p < 0.00003
1« snblects «ith CIS syapteM and p <
0.02 la safctects «ltk GI sTaTtoas.

Be* Tort CltT telephone cable
jplicers, eiclored S oc aore TT.
Ciec SOt vece <30 TC olJ.

l«acological and gastrointestinal
•Ifftoaa.
Ilevated ztnc protoporphyrin levels.
till POISOIIIG; KDOS1BIU POLLHTIOI;
IIDOSTBIII I1DICIIE: LI1D; K« TOEIC;
irmiS; CEITBal BEKVOOS STSTEIt
tIStlStS; IIIOSTIIaL DISUSES; BLOOD

BEFIBEBCE
riskbeln. 1.
Tkocaton. J.
Bloaberg, B.E.
Bernstein, J.
TalcUlias. I.
Hoses, fl.
1>arldo«, B.
Balkriskena, E.
Sicota. H.
Sellkoff, I.J.
1980
laerican Joacnal of
Pablic Health
7 0(7|:« J7-700






-------
lead
1429-M-1
ft
atl 207.2. » 327.4 C,  BP 17*0 C, vp 1.77 SB Bg at 1000 C. 1 •• Bg at 970 C, 10 u 89 at 1160 C
                                                                                     (COirilOED)
T.XSSBB



*071
Blood






























«072
Blood












4073
ood


















BXPOSOBB BOO



iBhalatiOB













































halatios



















IIIITTXCIL
•IT BOD


US































us













s



















IOBEJS
OF CaSSS


160































«













32
It


















BUGS



a) 16-2.0 eg/dl
b) lot given
c) lot given
d) lot given




























) 18-36 «g/dl
) 18-32 ug/dl
) 48-90 ag/dl
) 40-90 ug/dl










lot given
lot gives


















Hal I 6EIIUL liFolaaTloi
1
I
1
a) lot given 1 a) sorters IB saelters and cieiicals
b) 41. « ag/dl | flaat
c) 82.6 ag/dl | t) Cffice aad laboratory workers IB
d) 87.2 ag/dl | 1» «Mlt«r
I c) Prodactica worker la Tl >B«ltec
1 d) Cl«aa up aad Baiat«aaac« vorkers
I la Tl sa«ltec
1 loaitiTe correlation Titi daratlon of
| «aplOTB6Bt.
1
j loilnca ia secondary lead (Belter,
j leaphla, Tl, la scrap aaelter. Salt
| lake City, IT, aad at 2 lead
j cfe«Blcals factories, Joplia, BO.
1
j Clialcal evidence of toxic ezpoavre
j la 70 (ockeis: fatiqae, colic.
j gastrointestinal srBFtOBS, anorerla.
j afalgia, joiat pain, objectire
j treaor, eitansor sascle veakaess.
1 possible eacepaalopathy, aaeaia. lo
1 toiicity detected at < 40 og/dl.
1
| Vl€v«ted blocd Bcea altro^ea, cednced
1 c teat lain* clearaace, decreased ranal
j COBC«B testing abllltr.
1
| ItlD POISOIIIG; IBDHSTBIIL FCLLVTIOI;
| SBtltBBS; IICISTBI1I IEDICIK; IBID;
| BISSOUBI; TtlBBSSn; OTiH; 1DOLISJ
| tlOOO; BIOlCCVBOXaTIOB
1
1
a) 28 og/dl 1 a) Coatrola, boys
b) 20 ag/dl 1 b) Controls, girls
) 68 ag/dl 1 c| Bora
) 63 ag/dl 1 d) Girls
edians 1
| ?«tlent3, aaes 1-3 yr. 85% black, 10V
| Blspaalc, S* vnlta
r
j iBcream in systolic pressarc vita
j concentrations of > 40 ug/dl.
1
| CeltOlM; BYPEBTEISIOS; BLOOt
I IIESSBK!: 1EIO: BPTILS
1
S3 * or - 16 1 •> (orkers, exposed 2-37 souths (Bean
g/100 al j 12.9 aantks) , average workday 11.5
11 * or - 4 ag/109 1 tr, average work days 28.S/»onth
1 t) Costrals
1
1 Bale BD, ia aine corkers, Raraorilik,
1 ages 23-46 hr, e«aa kt 1.76 s, eeaa
1 wt 76 kg. Ccatcols, 4 office workers
1 at aiae, 10 ttaiTersity students, ages
I 23-42 yr. Bean ht 1.7S B aad aean wt
1 7« kg.
I lo observed decrease of aotor aerwe
1 ccadaction velocity of the alaar
1 aerwe.
1
| tllHlBK; ISO ITS; LZID POISCIIIG;
I IITTOVS STSTIB BISHS!S; BLOCD:
1 [IClCCHnllTIOI; IIDHSTBI1L
| ECLH1TTOI; llaD
1-
Esratncc



Baker, B.L. , Jr.
laadrlgan, P.J.
Barbonr, I.G.
Cox, D.B.
Folland, D.S.
Ligo, B.I.
Throckaorton, J.
1»7»
British Joarnal of
Industrial Rediciae
36:314-322





















Jhayeri, B.C.
Lavorgaa, L.
Dube, S.K.
Glass, t.
(Than, F.
E*aas, H.I.
197»
pediatrics
63(4):674-676





PaalST. P. -I.
Sry, C.
Dossiag, 1.
1979
International archives
of Occupational and
tBTlronaeBtal Health
43:37-43












                                                                                                                                                                                          -J
                                                                                                                                                                                          o
                                                                                   (BUT Past)
-------
7*39-92-1
ft
Itt TOT.2.
           BI 327.«  C.  BP t7M C.
1.77 M f« «t TOGO C, 1 •• Bg at 970 C, tO •• Mg at I ISO C
                                                (commit)
HSSUB



»07«
Blood









075












*076
Blood

















BOT7
Blood










rostriB HBTB



aalatloa









BgestiOB











































1IUTTICU
UTBUU


US









us












us


















us











•VB8EB 1 UIS8
or cuss i
i
t
1 I 40-3*0 Be/l
1
|

1

1
1
|
1

55 1 a) lot «ITCB
1 b) lot give*
I c) lot gives
I d) lot give*
I •) lot gl»«»
1 f) lot gl?»
1
I
1
I
1

I
I
1
i
I
99 | a) lot gl»e«
1 b) lot givn
1 cl lot giT«B
1 d) lot glni
I a) lot glf«B
1 f) lot gl*ea
1
I

t

1
1

1
1

1
t
1
IS I B) 3.1-13.1 aaol/1
I b) «.2-1).t eaol/1
1
1
I
I
I

1
1
1
1
m* i ecnuL urouuxoi
1
«
1
lot flliw 1 tatlaatai frcB qrapk. Direct
I dotenlaatloe a»l •stractloa
•
I letters, garage pereoBnol aid potty
1 lockers IB Svedlsh atrplaao factory.
1
| lIDBSTVIlt ICUBTIOI: COBMIMXTI
i ininitioirs: caDH0i: SIEDEI; IOOITS-.
| BIOOT; nilt; BIOlCCniOlJlTIOl
1
1
1 22.9 og/100 il 1 B) !«•• < 21 It. wpoicd
i 32.7 o«/100 al 1 b) loos 50-61 ii, oraoaod
i 37.2 ««/100 Bl 1 c) l«o* 70 aa4 em, exposed
I 19.1 19^100 al I A) >o*« 20-29 rr. eomtrols
1 20.B if/100 al 1 •) lg«* 5D-6« rr. eoatrols
1 17.3 oq/100 Bl 1 C) « 10.93 ag/100 el 1 laterclaeq*. saloa
e) 1*.93 og/100 al | el 17 so after opeelag of
n 19.21 vg/100 al I litereaaaoe. Bales
I df Before opaninc of isteccaanqe.
1 teaalea
1 e] 5-9 BO alter apeBiag of
j iatareaaeqe, feaalea
1 t| 17 BO after opeaiag of
| intereaaaqe. feeales
1
I tesideat* eitklB MO • of Uoavar
1 laterekaaqe tm tke V.C.
1
| QltYBO VII60CB.; BIOQO) UiO; BEtklSl
| lOTOHOTm
1
1
at lot give* 1 a) 3-11 jr eiposar*
bt lot gl
-------
lead
7*34-42-1
Ft
«tt 207.2. IP 327.4 C, BP 1740 C. TP 1.77 11 Hg at  1000 C.  1  •• Hg at 970 C.  10 11 Rg at 1160 C
                                                                                      (COITXIOED)
TISSSE

4078
Blood












4079
Blood













4080
Blood













1081
Blood
















EIPOSORB ROOT













































ngestlon
nhalation
















iiaimcu
BETH 00





























IIS
































101 BES
or cisss














110














a) 56
b) 70
c) 50
d) 69











40

















BIKE

a) lot given
b) lot given
e) lot given
d) lot given










a) lot given
b) lot given
c) lot given
d) lot given
e) lot given










a) 15.1-20. t ag/100 nl
b) 11.8-14.9 ag/100 nl
c) 10.4-11.1 ag/100 nl
d) 8.0-9.6 ag/100 nl











lot given
lot given
lot given
lot given














Bill | GEIEBAL IITCBH1TIOB
1
a) 32.5 og/100 nl | a) Blacks, Jane. 1970 and 1971
b) 21 ag/100 nl I b) Blacks, Bee-larch, 1976
c) 23 ag/100 nl 1 c) lispaaics, Jane 1970
d) 18 ag/100 nl I d) Rlspanica. March 197C
I Geonetric neaas. valnes estinated
1 frcn graph. Seasonal pattern.
I decreasing trend froa 1970-1976.
j levels correlated with gasoline Pb
1
I JE-36 so olds, lew Tork city
I it* tost; eaiLDRii: item STUDIES;
I BLOOD: COBPlBlTIfE ETALOATIOIS: LEAD
I BITALS; ADTOBOTIVE; POPOLAIIO*
| tlPOSUBE
1
a) 55.8 * or - 9.7 I a) 58 aonsnokers
ag/dl | b) 23 snokers, < 1 pack/day
b) 57.7 + or - 13.7 I c) 29 saokers, > or « 1 pack/day
ag/dl | d) siokers, high exposare (860 og/cu
c) 60.9 * or - 12. 1 | n)
ig/dl | e) KoBsnokers. high expasare (860
d) 64.4 « or - 11.8 | ng/ea it
ag/dl |
e) 57.8 + or - 10.8 I Sielter workers, average age 40.8 *
ag/dl j or - 8.2 yr. Los Angeles*
| CILirOBHIA; BLOOD; IBID: RETA1S;
| CCC071TIOIAL RAK1BDS; POPOL1TIO1
| ZIPOSVB^; SKELTERS; SROKIIG
1
1
a) 17.2 ag/100 si | a) Bales, Los Ingeles
b) 12.8 ag/100 nl I t) Feiales, IDS Angeles
c) 10.8 ag/100 nl | c) Hales, Lancaster
d) 8.8 ag/100 nl I d) Feiales, Lancaster
Geonetric neaas j Areas differed p«.001
1
| PITALS: PLITIIUB; PALL-ADIOfl; HID;
1 ECEOIITIO* inOSORE; OOCDFltlOIAL
I BIZAP.CS; CA1IFOEIIA; AOTOPSIIS;
I eiocD; xiDiETs; SPLEES; BAIR; OSIIE;
| I DIGS; BVSCLF.S; ADIPOSE TISSOS:
| IITBS; COHPABATITE ETALOATIOBS; III
| JtSSEI; CII1DA; HtlllS; A0TOnOTITE
1
1
1 16 ag/100 nl I a) Start of enploynent. no previons
1 55 ng/100 il | occupational exposare
I 78 ag/100 nl | I) 10-12 wk after enploynent
59 ag/100 nl 1 c) Siplayees relayed fron workplace
1 luring study, at tiae>of rencval
1 d) Enployees cenoved fron workplace
1 daring stady, 16-18 vk after renoval
I Considerable difference in rate of
I change and tlateaa state for Pb and
j la protoperthyrin
1
1 lead snelter workers
I A cons : BLOOD; ERTTHBOCTTES:
| IICOSTBUL BTSIEIl; LEAD: IIIC
I OfiAITC COSPOniDS; IIDOSTRI1I
| MROSPRE1ES; IWBALATIOI; SRFXTERS;
| CCCUPATIOIAl BtZARDS; CORPtBHIT?,
1
RE'EEBICE

Billlck. I. 8.
Cnrran, A.S.
Shier. D.I.
1980
Environmental Health
Perspectives 34:213-217








Brown, C. P.
Spivey, G.H.
Valentine. J.I.
Browdy, B.L.
1980
Journal of Toxicology
and Environmental
Health 6:877-883







Johnson, D.E.
Prevost, R.J.
Tillery. J.B.
Caeann, D.E.
Rosenfeld, J.B.
1976
EPA-600/1-7S-019, 235
PP.







Besley, K.I.
filbish, G.B.
981
Journal of the American
ndastrial Hygiene
ssoclation 42:42-46












                                                                                                                                                                                          N3
                                                                                    (IttI PIGI)
-------
lead
M39-93-1
n
lt» 207.2,  II 327.*  C.  8P 17*0 C. TP 1.T7 » Bo at 1000 C, 1 •• Eg at 970 C,  10 M Ba at 1I«0 C
                                                                                     icawnmrn
tlSSOS
«0*2
Blood








•oej
Blood












• 08*
Blood














4085
Hood






•OBS
Blood











IFOSOU XOtJII























lakalation






















Ingest ion











ifUTflcit
BRBOD
tttUTone








US













us














us



















mat SB
OF CISBS
13








1













a) 18
b) 12














100







1











IMSf
lot given
lot given








1 3.7-9.* QBole/1













a> lot given
b) lot giv«n














1.0-13.0 «g/108 Bl







a) lot applicable
b) Ml applicable











Bill «1IESU. IHFOIMTIOB
) 60 » or - 15 •> Batter? factory vorxers, expostra
gylOO al 1 6 ao-33 jc
1 2» » or - 1* | b] Controls
9/100 al |
1 lever eotor nerve conduction
1 velocities it exposed vorkets
I HID; T5T1LS; BLOOD; DdTED KHGMB;
| imOBS SY.S1U DISSISSS; OCCOP1TXOIIL
| BIMBOS; IIDTJSTBII1 FLIRTS
1
a) 5.1 asole/1 | rt-poi««ned cases
1
I 18-56 vr olda, iaiastrlal exposures.
1
I Ikooaiaal crasns, coastlpatica.
1 veiitiag. fatigue
1
I llll; IBID POI30H1G; iroosTBIU
1 tisiisis; HDdSTiin pcunnci;
| H100B; C1SI tKTOEItS; IOTOPSIBS;
1 tun: iiBitis; RITES: BSIII; iins;
I Bin; iivn.; sons: OTXTXD nisooi;
1 icutTS; SMITH Biziaas
i
a) 12.0 » or - 9.6 I *) Oeenpationallv exposed
nq/100 el | 11 controls
b) 27.8 « or - *.• |
aq/100 el i 27-50 Tr olds, in storage battery
I lannlacticlag plant. J8-»8 it old
j ccatrols.
1
I Iicreaaed rates of abaormal
I sttaphases vith ckronatid aberrations
1 in vitro.
1
1 HID; "Brits; CHWHOsoau
1 itinmoBs; ITU.T: HOOD; HEII.IH
| RlZtBDSs IVDHSTBZUi PLAVT5 !
I CCC««HIO«l BKI1DS; TOSUHT1O1
I iinsoiE; it vino miTsis
I
S.2 » or - 2.5 soyiOO | values lower than generally nported.
al | Ineiaved, contani»ation-free aanpliag
1 t«c»»lqn« aad cheaical analysis
1 Tcoible factors.
I
I 7-10 vr old ehlldres. reaote area of
I faBia lev Guinea
1
I eicco: me: anus: catmBEi; IE*
i eoiiu; mill ISMS
a) 112 ng/dl I a) Ca adalsslon
b) *7 ag/dl | t) 1 no after chelation therapy
1
1 23 yr old Japanese palater.
1
1 racial pallet, aild 1amdl.ce,
1 arioelaal colic
1
I iBcala, tiqh levels of arinary
1 Iclta-aaiaolevQllaic acid and
1 coiioporplvria.
I ElOOO; Kit; LE1D POISOIIIG: BITllS;
1 Jini: puns: occvpitioiii BIZUIS
1
(I SIT PISH
antatcs
IcnbT, J.a.S.
1980
British Javn&l of
laa.strinl Bediclae
37:133-1*0





Caapbell. B.C.
Seattle, I.D.
Elliott, E.I.
SoldberQ, 1.
Booce, B. t.
Beevera, D.6.
Tree, R.

Archives of
Environaental Bealth
3*(»);«39-««J



roral, I.
Sciaee, i.
BertaiTi, J.I.
lleasio, L.

Irchives of
Inviionnental Bealth
35(3) : 139-1*6








Pool*, C.
SBythe, I.E.
llpers, a.
1980
Science of the Total
Eavlroneeat 15:17-2*




Cblba, a.
Toyoda. T.
Inaba. I.
Ogikara, K.
Kicvchi, B.
1980
lev Saglaad Joaraal of
Aellci ne 303 (8> : *59






-------
lead
7U9-42-1
«
lt« 207.2. If 327.* C,  BP 1T*0 C. v» 1.7T •• Bg »t 1000 C, 1 •• eg at 970 C, 10 mm Bg at  11«0 C
                                                                                     fCOITXIOBD)
MSS0E
• 087
Blood
•088
Iloo4
1089
Blood
«090
ElOOl
»posm not
Ingestion
Xngestion
Insolation
Ingmtios
Inkalatlcm
iBgeatloa
Inaalatioa
aiaiTTicu
HBTHOD
Isotope dilation

IIS

TO BBSS
or CISES
s
12
124
7
11IGB
0.15-0.33 ng/g
3.31-3. (6 miol/1
100-370 09/1
) 38->120 ng/100 •!
) 90-120 09/100 ml
) 66-97 ug/100 il
) 61-102 ng/100 ml
) 57-61 ag/100 ll
IBll | 6B*ml nrOBIHIOl
|
lot given | lefore and after 1*2-215 ng/day
1 («icl»
-------
laad
7*39-92-1
ft
ItB 207.2,  Bt 327.* C, BP 17*0 C. TP 1.77 » Bg at  1000 C,  1  •• Bg at 970 C.  10 an Bg at 11CO C
                                                                                      (COITIBHID)
1ISSBJ
«0»1
Blood
•092
Blood
» 093
Blood
IPOSOSB iOWB
ngeation

Ingestion
Inhalation
IBliniCll
8 IT BOO

1ST
US
BUB MB
or cisss
38
38
w
19
) 19
) 28
371
MKS
Bot gin*
Bot givea
Bot givea
Bot givea
) 11-58 «g/dl
) 11-126 09/41
a) Sot givea
b) Bot glv«n
c) Bot given
d) Bot given
o) Bot glvea
BI1B | GSBBBU IBPOBB1TIOB I 8IHEHCI
I 1
1 1
1 1
1 1.91 * or - 0.66 | •) (others IB h oases »ith lead cipes I flvood, J.C.
aol/1 1 *1 Children !• houses vita lead pipes I Thoaas, B.
) 2.01 * ot - 0.63 I c) Bothers la houses with copper 1 Sheltany. R.
•ol/l I tlpes 1 1978
I 0.67 » or - 0.23 1 d) Chillrsn In houses «lth ccpper I lancet
aoVl 1 tipes 1 1(80781:1363-136*
) 0.93 * or - 0.81 1 1
aol/1 1 Bcther-ano-child pairs living la I
1 north valos d«r«lopBO&ts I
I IIV1TS: CBI1DSII; BLOOD: COBMB1TITS I
I iiiinnioBS: IEID: BIO»CCOBOI»IIO«: i
I BBIBKII5 »»TIB |
1 1
a) 16 ag/dl 1 a) Controls | Haaaoad, P.B.
b) 91 ag/dl I t) secoadarT lead saelter vorkaia I Leracc, S.I.
1 1 Gartsld*. P.S.
j 19-C* Tr old «ork*ra, 21-63 TC old I Bananson, I.E.
1 coatrols. I Boda* S.B.
1 1 Tonltes. I.e.
1 lettma reported 10» Incidents of I Johnson, 0.:.
1 aaurologlcal, gastrointestinal or 1 Pesce, l.J.
| ether aTBBtoaa. controls recocted 2* I 1980
| aach lacldeats. 1 Jonrnal of Occupational
| ' I Dedlclae 22 (7) :«75-»8«
I ElOOB: IBID; BIOIIBICITOBS: 1
| IBCDSTtlll ellRTS; 1IDOSTBI11 1
| PCIITTTOI; SBELTBHS; HBUTB EIZISDS; |
| CCCDPHTIOmi BlIIBOS: |
j ClSTBOIBTBSTniL STSTSB; BBOBOLOGIC |
| H1IPEST1TIOIS |
1 1
1 1
a) 0.11 Bg t | a) treated encepfcalopathy patleats I albert, B.B.
b) 0.08 ag * | c) Treated Pr-polsoalag patieats | Shore. B.B.
c) 0.07 Bg * |c) Untreated sablects ultfc hlqh I Sayera, l.J.
1) 0.0* ag 5 I Hood, aloh ec In tooth Pb lerels I Strahlo*, c.
e) 0.0* ag * I a) Vatreated sab-teets tilth lo« blood, | Inelp, l.J.
Mdlaas I Hqh tooth PC levels | Pastecnack, 3.5.
I «) Untreated sabjects «lth 1m blood, I Tcledhoff. l.J.
| lev tooth Pb levels 1 Coras, F.
1 I Clalao, J.l.
I Chi Urea In Pb register of BI City, 1 197a
1 iitlinqs of ceqlstcy cases and dental I Invironnental Health
I clinic patients. Host «ere tlacX, 1 Perspectives 7:33-39
( Cccn lo*-lnccne fanilies, ages 5-15 |
1 yi, n«a< 2.3 yr. I
t 1
1 liqk incidence of psychological I
1 referrals and behavior pcoblena in I
1 a) , b) , c) . Convnlsioas in « j
j catieats. a of 6 encephnlopathy j
1 patients nentally retarded, aoae j
j diagacsed organic brain syndrone or 1
I aeizare disccders. |
1 1
1 II1B; 1R11S: CHILDREB; IIB |
| FOIHRTOB; BfB TO8K; SIT1L PCISOBIWC; |
| KB1VIOB DISCSOBBS; BSTIBDITIOI; I
| E10CD; TEETH; P1IBTS I
1 1
                                                                                         (IEII  PIGS)
-------
lead
It
lt» 207.2, If 32).* C. 8P  17*0 C, TP 1.17 aa Hg at  1000  C,  1 Ba 19 at 9TQ C, 10 u I 20
4 122
t TO
1 60
»
MICE
«) «-11 B«f
k) 7-M 1191
c] 4C-64 agf
4) 37-S« B4*
») 3-2* og/IW Bl
b| 7-19 ag/lOO ml
c) 6-20 og/100 ml
4) 5-37 09/100 si
) 7.0-26.5 ng/100 »1
1 2.3-37.1 ng/IOO el
7-».0 aaalA?
MM i enttit, xiroiaiTioi t tsnREicE
1 1
i i
a) 9 » or - 1 mgl I •) Control* t Baoharaa, S.8.T.
b) 1» * or - 3 BO* | n irposea. M tmleltr | c«l»«, S.D.
O S« » or - 3 >4« I e| Erpomd. «r«Pt<»«tic ai< 1 Sonic*, B.C.
4) »5 t or - • igX | tlock«ie*l ii | liTlroBMntal S»a«rch
I teiiedtT I 22:2«»-270
I tc*Unal rb (sac •!>« Pb la I
I kmogloblB tiaetim. 10,000 n I
1 ttactloa, »mt tt»» d» |
1 1
1 m-»po»d ladacUlal *ork*», *g« I
1 25-«5 TT. tipaacd workers tro» Pb j
1 inltlni pl««t. |
1 »ems«4 rlak of -toxlelty *t lo« 1
1 blood Pb l«*«ls IB MTlwr* vitfc I
1 4l«i»lslL«4 caoacltl tot sntkuixlaq t
I lev »lxc«lar «t Nt-Undin? protsio. I
1 t
1 ICOITS: U1D POISOIIKi BIOOI; |
1 mosrnu einicift: ntsgtiRit r
i CRICK; tint ineatsia. nam i
1 CCCDPIIIOIH 81Z1BB3 |
1 1
1 t
a] 10. S « or - 3.7 | a) ratiats. 8«lb1 | Cbildna'a BoipltU I DoiBaa, H.B.
bl 11.1 « or - 3.0 t *>> Sekool ckildna, B«lbo«ra«, IBB« I 1>80
•4/190 B! | utocn | B.dical Jonnal of
c| 11.* + or - 3.5 | e) Scaool children. St. Jtadrns, I listralla 2{C) :315-3t«
•«/100 al 1 Mai-c««l »t«« [
i] 13.3 * or - S.5 Id) rrt*CBool cttUraa, lelboora*. I
oq/100 B! 1 laa«r snbnrtg |
1 TCBOa* SBBfllS i
I IKvated Pb <> 25 aq/al| In 10< of |
1 Mlnoan* Fnschoalani if from pica. I
1 Era-school a»d •ekool-aoe c»ildr»B, I
1 StaU ot Tletocla, lB«tcalla I
( lOSTdlll; CniDEM; BLOOD; lltU; |
i Jioiccammoi; nsn utts; amis i
i i
I i
1 15.1 * or - 0.59 1 a) Controls ( lta*«cjs. 8.
4/140 ml 1 t) tasidaxta ot point »4 area 1 Foals, 1.
) 1«.« « or - 0.90 I | Bernard, a.
4/110 Bl 1 lean, ««an a«e (2.3 Tr, froa 1 Bacbet, J.p.
S.S.) 1 Cd-pollated area ni*4«>. tit 1 1»40
1 controls, »an aoe »1. 1 jrr, troa 1 International Ucblvas
1 ckatlarol. Ealqina. 1 of Occupational and
1 1 SaTlroBBeBtal BJealtb,
1 BLOOD; BLOOr PLtSSt; ISItti C1DSIM; [ (5:271-27*
I Hip; XSSCVI1: ItKl SIHMS; SEtSIfff; I
I let: KPotiTtoi sxposoiE; UDOSTEIH i
1 ICtWtlOl: SBBlTEtS; KIDVEI tISHSIS I
1 •
1 1
3 aaolAg 1 l*ad polsoiieq casea ! Iraki, s.
edlan I I Banna, T.
1 24-59 rr old Japanese lead «orke» 1 Tanaglaara, 5.
1 1 oaxlo. I.
1 f«riptetal narre coa8»ctioi wlocilj I 1980
I I8C*| cornlatel vltt Blood Pb. BCT I International Icealrea
I laproreaeBt after caelatioB IherapT. I cf Occupational and
I I ZBTlronBeatal Maltb
I 1110; B1OCO; POP01AWOS EIPOSTSt; 1 ««: 151-157
t CCCVPKIOIII tatnos: IBOBCICCIC i
1 fllHIESflTICU; aiTllS; LEIS t
1 PC1S01I16 |
1 1
tlttt f kGt) ' '
-------
ft
Jtl 207.2, RF 327.* C, BF 17*0 C, TP  1.77 u  Bg at 1000 C. 1 » Vg at 970 C. tO •• Hg  at  1160 C
                                                                                       (COITIBVED)
nssvs
»098
Blood
(099
Hood
4100
Blool
1101
Blood
• 102
Blood
IfOSOBS IOOTI
ngestios:
Ingestion
Inhalation


iiiimcii
BBTBOD
ix
BS
US
us
1ST
•OBBEB
OF CUSS
00
) 5
) 1
a) 60
b) «
cl 70
a) 32
b) 7
a) 22
b) 22
c) 10
11KB
or - 60 09/100 al
) 0.17-0.25 09/9
) 13.8-11.3 og/q
a) 2.3-37.1 ng/100 »1
b) 6.2-28.7 ng/190 il
c) 7.0-26.5 ng/100 al
a) 1.0-2.7 uaol/1
b) 0.4-0. 8 uaol/1
a) lot given
b) lot given
' c) lot given
BBiB i entail nroiBiiioi i iBPiBEici
1 1
i i
1 1
ot applicable | feaitlve correlation »Uh 1 roster, J.8.
1 environmental Pb soirees i lonria, D.B.
1 1 Stinson, I.
I 9« black ana 6 Bispanic children I 1*79
I 1 Irchites of
I less of appetite, nausea, I Znvironnental Health
1 constipation, nental retardation I 34(5) : 368-371
1 1
1 Brain damg* 1
1 1
| III jnSIT; CRIID1S1; IBID PCISGlTIG: I
I tIRll SETItClTIOl; HOOD; 1119; )
| BR1LS |
1 1
1 1
) 0.19* ug/g 1 •) 10 and 210 days after tracer doses t Sablaovitz. 9.
) lot applicable I of 68-20* nq/day pins dietary intakes 1 Vetherill. G.
1 of 1*2-215 ng/day as nitrate. j Kopple, J.
1 treathing nn filtered air 80.7* of the 1 1975
I tiM and lead-filtered air 19.31 of 1 Proceedings. University
I tbe tine 1 of aissovri Innaal
I t) 0 and «0 days on air filtered to 1 conference on Trace
1 rcnove Pb. (49 yc old) . Back to 1 Substances in
1 initial level after 20 days breathing 1 InTirouental Health
| »fllter«d air. 1 9:361-368
1 1
I 8«althy 25-53 yr olds in netabolic 1
I vard. lo» Pb diet up to 6 no. 1
1 1
1 Tito: ICTUS; HIIJB&I. mTiioiisfl: i
1 H1I»: FKIS; BLOOD; 118 POIltJTIOI: |
I 01EH UI1S; 1D01TS: C01P1BITITI I
I miomo*s; OISTS i
i i
I I
a) 1>.9 ng/100 al 1 a) Residents of liege (lost polluted I Reels. B.I.
b) 1».« ng/100 nl 1 area! 1 Lanwerys. B.B.
e) 15.1 ng/100 al 1 t) lesidents of Bcassels (leas 1 Sachet. J-P
Seonetrie j tellnted ar«a) I Bernard. 1.
1 c) Control area 1 1981
I R«ans and eunnlative freqaency I Environnental Besearch
1 distribution* not aach different I 2»t 117- 130
I hctveea tbe three groups 1
1 1
1 8«altay snb^ects >60 yr old, I
I residents of the sane areas 25 yr. I
I Belgian 1
1 1
1 SIISIUI; iBDITS; let; BLOOD P11SB1; I
1 Ollit: CICHIHH: LtiO: BISCORI; 1
I BIT1LS; ZTIIC: tRDOSlBIJlL 1HISSIOHS; |
I IllOTtBTM tCL10tIO«: POPOlMIOt 1
I JIPCS08E; OBEII 4SBSS I
1 1
1 1
a) 1.6 anol/1 I a) sorters at Pb line 1 ttansen. J.P.B.
b) 0.7 naol/1 I t) Controls I Dossing. B.
1 fstinated frcn graph 1 Pauley. P.-E.
1 1 1*61
1 Residents cf Greenland. 22-46 yr old. I Journal of Occupational
1 1 Bediclne 23(1):39-«3
1 GBizniii; » COLTS-. BLOOD; OEIII!: t
1 I!«B; OCCUPMIOlkL BlZlSDS; MHHIG |
t t
1 1
a) 2* ag/dl I a) Gout patients, no renal disease, I Batanan, T.
b) 26 ug/dl I 1C had prior Pb exposure I naeeaka. J.K.
c) 26 ug/dl I b) Gout patients, renal disease. 10 I Haddad, B.
1 had prior Pfc exposure | ?epper. E.
1 c) Patients, renal disease, no gout, I landy, E.
1 ne Pb exposure I nedeen. B.P.
1 I 1981
1 32-78 yr old gout patients I Hew England Journal of
1 1 Bedicine SOU (9) : 520- 523
1 IE« JIES;i; » DOLTS; KIDRET DISE1SES; |
1 EtCOD: HBIII; LE1D |
1 1
(•in mot;
-------
lead
7*. 39-92-1
It
It! 207.2. I? 327.* C. BP 17*0  C.  It  1.77 u  Rg »t 1000 C. 1 ll Ig at 970 C, 10 u Bg at  1160 C
                                                                                      (CORHHSO)
TISSUE

«103
BlOOd







*10*
BlOOd






*105
Blood









• 106
Blood,
evils













Bisoson BOW

















lagestioa









Xaaalatloa
Dersal














IBlLRXCat
1 ETHOS








US







us









us















IU1BSS
OF CISSS
•I *8
b» «S







1) 88
b) 11*
C) 31
4) 33





a) 30
b) 20









20















UKE

t) 20-125 09/100 ll
b) 22-80 ag/100 ml







a) lot giv«B
b) lot gi*»
c) lot gi»en
d) lot gi*ea





a) tot gi?«
b) lot giT«n









a) 39-5» ag*
b) 107-150 «gt
c) 172-209 ag*
d> 102-120 ng«












SUB

a) lot giT«i
b) lot gi'ea







a) 180.0 ag/1
b) 268.* og/1
e) 668.3 ng/1
d) 818.1 ag/1





a) 25.* * or - 12/1
ao/109 ll
b) 17.8 « or - «.9
oij/100 al








a) 46 » or - 3 uq«
b> 130 » or - 8 og*
c) 193 * or - 7 ug«
d) 110 * or - 3 og*
(S.8. )











ei»ui irroiaiTioi

a) lortars aipoaad at least 1 re
b) (octors pnTioaslT upoMd > * ji,
>ot exposed (or 12 or »or« » prior
to *t«ir.

it BITS; Biooo: DHR: ma:
CCCOP1IIOIJ1 H1I1BB3



a) Oat»«rsiti atadtnts, esploTeas
t) workers, steel ladistrr
c) lorkers, battery factory
d) lorkers, secoadarr Pb sielter

17-63 yr old Caucasians
caiiBi; loons: BLOOD: SUITI; w
1ITO IULTSIS; HID: NR11S;
OCCtJPlTIOIH BUMDS: SBE1TBJS
a) HeatallT retarded ekildrca
b) Coatrols
Erobablllty ef aeatal retardation
iaereased *h« Pb exceeded 800 vg/1
later.

2-5 yr olds.

me: inns: oiimcHs vim:
cnufsi; ititii BBTUUTioi; BEHTB
CI!»OS

a) Coatrols
t) Bxposed, BO toxtcity
c) Exposed, syaptoaatic and
tiocheaical crid«nc« of toxicity
d) Exposed* syaptoas suggesting
toxicity
Icn-«x!>ose3 industrial vorkers, ages
2!-*S yr. Zxposed vorkers froa Pb
saeltiag plaat.
lacreased risk of toxicity at lov
blood Pb leTels IB workers vltb
lisinished capacity for syBtheslziag
lev solecvlar «t Pb-biadiag protein.
DOITS; HID POISOIIIS: BLOOD;
ivosniti BE0ICIWZ; T.IID-. IIDOSTBUI
I1RS; OCCOPtTIOIlI a»Z«BOS
1EFEIEICB

llessio. I.
Castolli, H.B.
nonelli. o.
Toffoletto, r.
Zoccketti, C.
197»
iBternational ucUves
of Occupational and
EBTlroaaental Health
««:127-132
P'aa, l.T.S.
1981
Joornal of Toxicology
aad laflroBBeBtal
Health 7:273-280




Seattle, ».D.
Hoore, B. B.
Goldberg, 1.
Finlayson. 8.J.W.
Backie, B.a.
Grakaa, J.F.
Bain, J.C.
RcLarea, 0. t.
Rardoek, B. R.
Stewart, G.T.
1975
lancet 1 (7907) s 5 89-592
Bagnavaa, S.B.V.
CalTer, BlD.
Gonick, B.C.
1980
ZoTiroaaental Research
22:2«*-270










(Htt P»SB)
                                                                                                                                                                                             oo
-------
l«aot 9l«*
b) lot gl«B
mi i GIIIIU urotamoi i nnisicz
I i
« i
I i
23*10 ng/100 al I it Coitcol* 1 Taccaro. S.
•8.3 M/100 *1 1 *) OccipatioaallT expoeed te about 1 | Barakigiaii, C.
I ig/cm • list with J.7-12.»» Fk 1 Coloibcttl. 6.
j itTtkroeyt** 1 I*ncl, r.
1 I lol, l.B.
| Itlllil factorr MCk«rsl HMD f PiqqUco, T.I.
| «ipo»»r« tii« of ».« yr I paqxno, 5,
1 j Tola, 8.
| Io4«tmt« to MT«C« litabolic •ffccti 1 1)80
I tm »0t of «ifos«4 «ar1mrs. 1 Iit«r»«tioiwl ircklT«s
j I of Occupation*! and
I IULT; 19tHlS; 1MB !O1SO*II6: BETal I BnlcoBMBtal Health
| TOISOniS; CCCTPitTOKl DISUSES; t »S:35-»«
| ROOD; OIII1; COSMtltlTB |
1 imomois; IIDOSIJIH ncini: i
1 iiisniam nnogs; I.SIDJ units: i
| CIST: HalTB UZ1IDS; I1DOSI1H1 I
) IT90STHIIIS; nilUTIOIi OCCffP»TIOIIl |
I llIMtS |
1 1
I 1
) ««.53 ng/dl 1 a) 111 etlllna I Sos«n, 3.1.
1 7» * or - t (SI) 1 k) 12 ckliaco vitk initial ft levels I CkesMT, ».»•
g/«l | > 60 n/ai I Baistci, k.
1 21 » or - » «St) | c| IV* 12 ekiUrett in b) aft«r I Detuca, B.r.
V41 t ckelitloB tk«npi t Bekatfey, K.I.
I I 1»80
I 1-S it oil*. IT. I lev I»9.1»4 ]o«rul of
1 I «*aici»«
1 »»; TITUII 0; CBIIDNI: in VIE; 1 302(20) :1128-1131
I E10CD; COBMUTITI ITHff»TIO»S: BLOOD I
I SJttJIt! NCtlBCtlSl; RRIBOintS: 1
1 BtnoncnoiiMiciRioLS i
1 1
1 t
166 ug/1 I le*-oce«pitiaullr exvonl. I lTgo»i«, E. B.
1 1 Boll«ba: i 2«(ioiti«i3-i«ia
1 CC«|lt>TXlI nilOKIWIS; KIISDIHSIT I
1 BIHODS; llICi OCCUPUIOVal UCUDS 1
t t
1 1
32* of dose 1 t*ake, aftec -eea* 1«D4 expense* of I Borrow, P.I.
1 130 pq PbClJ u 0.26 n acrogol or | Beltsc, H.
1 11.54 <« fb(C8)2 *• 0.24 « iwoaol. I Into, r.
1 S«ak tlie 2019 «i». IstiMted blood ) Sibt, r.E.
I »cli*e 6f boil «t. 1 1*80
1 1 CBTiraiMititl B«9«atck
I 20-56 Tt old*, SS.0-95.4 kij. Bo 4 21:373-38*
I kl*toCT of talaoiarr tis*»«. j
1 1
| II»D; UKSi COBNtlTITB BTttOaTKIS; I
I HOOD; inumoi: in ?oiimoi: i
1 tMsaumn imoas; IDTITS; m TOBK i
i i
1 l
a) 16 * or - TV | •) S*b1eet* »itk Bocaal re alsocptioa I »at»o», i.s.
t} 47 * or - IK | *aa **»* feiritie. InelB 1 Una*, 1.
1 t) S«b1act* tltb klgk Pe absocptioi I floor*. t.B.
| «»a nbnoiaal aene I«rriti». t 198«
| Significant fosltln eorrelatio* I taacet 2(8188) :23«-237
1 t«t«**> oral Pb aid F« absocption. j
1 35-70 TT old*. Halted Kiaadot. 9 I
1 patients »itk chroalc blood loss, j
j taaipareii*, or TevemctioB tor I
I secoBdarf polfcytkeeia. 1 *CTaal I
j tlcgfl daioc. j
1 (
I oinr? itlisccB; BLOOD SOURJ BOB»: i
1 tlOICCQIWHTIOl; lETIBOLISB; II TITO 1
| III1TSIS: ltd; LHB I
1 <
tun MGQ
                                                                                                                                                                                                v£>
-------
lead
7US-92-1
ft
It? 207.2, ft 327.* C, BP 17«0 C, T?  1.77  aa  Bq at 1000 C. 1 aa 89 at 970 C. 10 mm Hg at  I ISO C
                                                                                      (COItlmtD)
1ISSOI
•112
BOM
• 113
ton*
»m
Ben
«115
Sral*
UPOSOBS TOOII




IBU.TTICU
IZTHOD
US
I-r»r spcctroi
Elec troche •
Elec trochee
WBJJB
OF C1SES
»> «2
b) S3
O 1»
22
1

11IGE
*) 1*>21« PS*
b) 11-13* Fpe
e) 0.3-15 ppa
15t> rt
20-11* lj/9
•) lot «if««
b) lot gi»«n
c) lot git en
) lot oi»«B
lot gl»e«
mi i eiiiBii XMoiBHXoi i tcnmcx
I I
i i
*) 72 * or - 40 ppa 1 •) Black adqlts 1 B»* (27-75 yr oil) at I 1980
I storage battatT plant. I British Journal o*
1 1 Industrial ledlclne
I SIMM: BlOOt; BOtTS; n TITO I 37:109-113
1 1II1TSIS; LI1D: IR1U; IICOETBIil 1
| [HITS; OCCOPITIOMIL MUSDS; |
I PCPSUTIOI 1IPOSBB! |
1 1
1 1
a) 136.05 noyg dry lit I a) lib I Caipbell, B.C.
b) 3T.50 ag/g dry »t 1 t) calraclii { Beattla, l.B.
e) 163.33 ag/g drr "t 1 e> Stera<» I Elliott, S.I.
1 Utopsy saiples f Coldbarg, 1.
1 r Roore, B.S.
1 3« JT alt aetal buraer, ecposel | Bearers, S.S.
1 4«ring a building 4«Mlltloa 3 ao t Tree, H.
t earlier. Killed la industrial I 1479
1 accident. t JrcKiTes ot
1 | ZaTlronaental Health
I Ibdoalaal craapa, coBStipation. | 3» (*) : >39-«»3
1 foaitlng, f»tigne (
1 1
1 1111; KID IOI50III6; IHDtJSTKUl 1
| CISElStSi IIBBSTHll POLLOtlCI; 1
I E10CO: CIS! tlSTOSISS; ITtOPSIIS; |
1 8I1BT: MDins: »ra»B?: aau*: MILS: i
1 BUS! IITEE; BOIES; OIITED KIIGCOS; 1
| 1CVITS; BtlltB EIUIDS I
1 1
t 1
) 0.99 ug/g dry «t I a) coctet I Caapbell, B.C.
I I. 10 ng/g drr «t 1 t) Stei I Seattle. l.D.
I IgtonsT saaples | Elliott, B.I.
1 I eoldberg, ».
I 3* yr old aetal cocacr. eipoael I Boors, B.B.
| dicing a baildiag deaolltloi 3 ao 1 Beerer*. D.5.
I earllert Killed U industrial I Tree, 1.
I accident. ( 1979
1 1 Ircbivas of
1 lMo*l»l craaps. coutlpatlon. 1 Eariraaaeatal Health
1 .eiiting, fatlqiej | 3»(6) :»39-»»3
1 1
1 mo: IEID tcisoiiiG; ISDDSTSIIL i
1 EISI1SI5; IIBOsnilI PCllonci; I
1 cioci: cist iisroiiBs; imopsirs: i
t met: iiBiiis; *nTES; BIIII; tins: i
| IIII: 11 TIP 5 90115; OIITED CTIGDOB; I
I ItOlTS; 9II11B BlItSDS |
1 1
(»1II MSB)
                                                                                                                                                                                           oo
                                                                                                                                                                                           o
-------
7«»-92-1
Fb
Itl 207.1, el 327.* C. BP  IT«0  C.  T» T.7T » B« «t 10011 C.  1 •• Eg at 970 C, It u 14 at  1160 C
                                                                                       (COIfXRTOD)
HSSfS


1116
Braia























• 117
treatk











1118
8r*atk












• 119
•air









IKS1SI BORE



























Inhalation












Inhalation
























Hitmen.
BET BOB

US
























PIXB












Mil













US










I08.EES
OF CIStS


























1












1













a) 31
b| 22









MISI


0.051-0.152 ag/g
0.012-0.050 ag/g
0.059-0.112 ag/g
< 0.010-0.018 ag/g
O.oat-0.183 ag/g
< 0.008-0.026 ag/g
•at wt


















99-0.03 ag/ca a












not giTaa













a) tot given
b) lot given








(III
Bill | SIIIS1L IlTOtSaTIOl
1
1
0.067 ag/g 1 •! City ccsltenta. ioaar floors.
0.039 «g/g I total Pb, 8 nb-]ecta
0.087 ag/g I tl City realdents, lover floors.
0.011 ag/g 1 trlsUtyl Pb, 8 ssbjecta
0.07S ag/g I e] city reaidents. apper floors.
0.011 ag/g I total Pb. * aablecta
at vt 1 <) CltT resident*, appar fleers.
Mdiaas I trialkyl Pb, a subject.
j <> Sifearbs, village residents, total
I Pa, 10 sablects
I fl SBBarbs, village residents.
I triaUyl Pb, 10 aob-lects
| Decreasing it levela vitn increasing
I age (P < 0.05)
1
1 latopsies. lesideata of Copenhagen,
( ita stbarba, aad of vlllaqsa oa
I Zealaal. lq«s 12-S» vr.
1
| finall: 1BDUS; 1DTOPSIIS; cRluni;
I EMIR; in poiLtrtioi:
| E10aCC9fl9UTlaa: 01BII UE1S; LIIB
I C1SUIC COHCOIDS
1
1
lot glvea 1 liter aatoaotlve Pb fcalide aerosol
I eipoaara. levels a finctlon of
| particle size. Zstiaated fro a graph.
I TUal valaae of about 900 ca s ant
1 riselntorT freqaeacT «f 15
1 cvcles/iin salatalnei during 10-ain
1 aaipllag tiae.
1
| IStlTH; ISORKB: CaLCIOIl; C BIO SIS!;
i mi: 17TOBOTHI: ttmspsni;
1 PIBlICOUtTS
1
1
6.6 ng 1*1 saapled at rate of 1 Vela. 2-10
1 aln after earalag 8 arc mldlag rods.
1 I«ar detect lea liait.
1
1 aai.wcsi.tT pvysics shop, Florida
1
I noBioi: moils; BBIKB: ULCIOR;
1 CStOSnP,; CIBORXDR: COIPBR; X10R;
I IlIC; 1M6IIISE; nCKII; TOT1SSIOR;
I suirira: Titinm; THioroB; me; IIB
1 ecttntOI; f«8ES; IlOfSTBIlL
1 iTHospHies: met nsntrs
i
I
a) 23 ppa 1 a) learaiag disabled
b) a ppa | b) Controls
1
1 leaniag ditableS and aoraal 3rd and
1 «tt grade atadents in Canada.
1 CltCIT*: RietSSIOR; POTASSIOR;
I SO CIOS; CltHIDR] COIUT; COPKB;
1 Itoi; !.«»; auetiESt: zxic;
1 eetCBH*: iitnoR; uncoar: RETILS;
1 HilB; CSI1DBII; CltlDl
I Past)
ttriiegct


i«lsen, T.
JeBsea, K.I.
Grandlean, p.
1978
tatare
273(5*71) :«02-C03



















D«saedel«er, E.G.
llBCkester, J.V.

EBVlroaaeatal Scleace
and Techaologj
9 (101 j 971-972







ItselssoB. K.B.
Desaedeleer, G.6.
Johansson, T.B,
VLacheBter, J. R.
1«78
IBaals of Occnpatioaal
Rygieae 19:225-238







VU1, 8.0.
p*rkee, a.
1977
Science
1«at«13) :20»-20«






-------
Pt
1W 207.2, B« 327.4 c, IP 1T»0  C,  TP  1.77 HI Bg at 1000 C.  1  •• Bg at 970 c. 10  •• (g at 11«» C
                                                                                 (canntmi
TISSUE
Bali
4121
•ait
• 122
Bate
4123
la It
iiposni ton




ItUTtlClt
ffXTBOD

1ST
US
ElaCtCOCkai
•unit
or cisss

t
aj 45
hi 70
cj *4
a) 65

mei

1.S3-7.«T BS/J
a) 15.3-19.7 «g/g
b) 19.3-59.< •«/»
c) 13.9-16.9 OJ/J
1) 4.0-13.7 afl/g
at gt»«o
Sill | SEIM1I IBTOMITIOW | BBPIBICt
1 1
1 1
1 liTl«. 24 ncnswatatln 1 CLlttlebanagh., S.
1 tt«-4uL|lla tr«atsj««t« are I 1980
1 tab*la.t*4. Ik* fvastblU.tr of a I sci«aca of the Total
1 koltstle, ao-vask palter for latr 1 CailronwM It: 53-75
1 «a»lTHs Is oatliaei aid supported. |
1 1
i iiritt; met IZMKHS; tins i
I losnuii; BasotKBiir BETHOIS; \
\ enusi pMTFiist coBptimn t
I iTiiniiois; itoBjioa: IRIKHI; i
1 iBsnic; sum: BBOSTW; cumim; i
1 C11CI9B; CnCBtlB; CBOBXOB; COBI1T; 1
I copptit siitrui: sminus: GOLD; i
| tOBUB; ItOB; IltTSITOS; Hit; |
i Rie«Bsimt Bueaitsi; SIICHBI; i
i ectiBHim; ixcKn: PHOSPEOBBS; i
I EOTissm: siBiDimfi SttMiosj i
I siiicai; SIZIBS: soong; sisciiniB: t
1 Sturm ; TIB; TltkWIOB; TVBGStBf; |
1 n»c: Tiicoiiffe i
1 1
1 1
».»0 » or - 1.33 ag/i I Jaacd kaic - 10 «k perlofl. BailT I Chtttlcboroagb. S.
I «OM« Of 100-300 K <•• 29 | Steal. B.J.
I aatoralaatteis. t 1980
t t Scioaca of the Total
I lajittalla | EaTicoaMat 15:25-35
I iDsranii; em; GOHTLMHTZ i
1 ITltaitrors; c»»n»s; coritB; itttt; I
I Bitus: tsici it tains; tuc i
i i
1 1
a) 2».S ng/g | a) Bales. las laoales I Johnson, D. B.
b) 29.0 tg/a | t) T«aalas, lo« Inqalcc | Pravast, 1.1.
e) IS. 1 cj/a | c) Bales, laacastar I Tillecj, J. B.
3) 9.8 ng/9 1 at Maalas, laacaster | caaau, D.E.
Seatetclc a«a>a i lt«as Uffcni p«.OD1. Talaes for | Bosaafaia, J.H.
1 loag katr. | 197C
1 1 EP*-600/t-7«-019, 235
1 tniLS; niimi; piuitiaB; Lsio: i pp.
I lopratTtoi Eiposmx; OCCOPITIO»IL i
1 nztsis; cturosni: IWOPSXIS; i
I ttooo; viiiETS: Sfiinr: BUS; naivi; i
I tSiCS; TCSCUS; 1MPOS! TZ5SIX; I
I IITW; CONPlUTtTt IT«ltJlTIO«S; R1 1
I JE1SET; Ckllll; SHIBS; IBTOBOTITI I
1 1
1 1
45.17 tg/t»T: si CUTS: IESTES; BULXB: mis; i
1 B»IB; llfEt; MIES; OHIID mSOOH; |
1 ItDLTS; BCU1I BUklDS |
1 1
                                                                                                                                                                                 00
-------
Had
7««-S2-1
tt
Itl 207.2,  It 327.* C.  BF  1740  C.  » 1.77  ••  B? at  1000 C.  1  •• Hg «t  »7« c,  10 •• «« at  11C4 c
1ISSIB


«««
l«ir





















«12S
Baart













MM
(IdMT













KfOSVBE BOMB























































UURICll
BRBOD
























El*ctcoch*a














US














BOBBIE
or CUB
























1














•1 »2
b| SC
C| 11












•IKS

























lot 9iT«a














«) 1S-2W p;i
b> 15-10* ppa
C] 1.«-7« ppa
Isk vt











•III | 6BBIBIL IirOIBlTIOl
1
I
| 1 ml« of trorld lltentac* OB tha
1 acc«»al«tloa ad biaoracatra^iai of
t Ml«et*t toxic tr»c« >«t«la i» Vi»«
I litt til vail* »md ottet laiullu
| l*li, fmr. ••!!•> cl«« *Dd boot*.
t l»l»l»t«4 bi 9«oqrapUc »r«t.
j ««b-}«ct3, ami, «4*. «xpo*«c«
I gc«Umt, a>U.T*M la pp«, an*
t *itkoEitr £«• OT« OO E«f«c«aora.
I
1 mictj lasiuut: ciiuta; cnrui
I itinci; tJMH: nons wst: in
| Illlin; SOUTB IBEBICI; SODtBBiST
I Jill; DIKZD HTCDOI: OflllD STITIS;
1 itii: vuis; mm; iirnoit;
1 iismc; toieis cwmii: cnmni;
1 COIllTi COHM; 1UB; (1I8COSI:
I 1ICRI; SfLJIIOB: Tlli T1HOCTS; til
I lomrtToi: iiiRiL ?ointnio«s;
I cioiccvniMioi: BIOIIBICITOBS; L«B
1 loiiotioi; ro?otiTio» tiMsnsE: urn
1 tctLtmow: TUCI nMiirs; ait its
i
3,90 09/9 dry *t I latopST •••(!•
1
1 36 ji oil Mttl tm«c, «iiK«ea
1 avclio, a b«lldlm« lawlltloi 3 «o
1 «atU«c. 1111*4 in liflvstiial
I ioeU*at.
1
1 ItJoBltal ccacps. co««tip»tioii.
1 Kiitlag. fating*
1
1 me: u» icisonie: iiDustint
i nsnsts; iitnnut *eu.0»c>;
1 HOOB; CIS? CISTOBIIS: ITCOPSIIS:
| IllBTj SIDltTS; IEBTES; BBIIB; ItlLS;
1 But: itiis; BOIES; mmiD moron;
I ItntS; BUI1B BIU1I1
a) 52 » oc - »7 ffm I a) Hack a««lt*
b) 3« » oc - »» pp« 1 t) Caneailai •Salts
e) 26 » oc - 23 FP« 1 e| Ckllitn
Mb »t |
1 latopalM fcoa hospitals It Roctfc aid
1 Seat* Cacoliaa. Blacks and
1 CnetaUM. Idalta. a«*« 1«-91 re.
1 Ctilliea, agai t day»-t it.
1 MTIT.S-. SOUS; LITEt: SToaitS:
1 ItfflTS; CBTlDBf; CIDHOR3 IMC;
1 UK; BOITB CUOlIIl; SOall CMOLII1;
1 IBTOPSISS: BIOiCCBHBLlTIOi; BlCIlt
1 S1VCTBS; IOB; SIWKIIS; TOtlCCOSi SBI:
I iconuM
i
(HIT »l«t)
BE7BBBICE


JoakiBS. B.I.
1»79
FPI-600/»-79-fl«9. ISk
PP.



















Caapbell, B.C.
(•attle, 1.0.
Elliott, B.I.
«oldbac«. 1.
Soote. S.B.
Bvwreca, D.s.
TE««V H.
nn
Ir eh lies of
EaTiraDMOttl Etoaltk
3«(S)t«»-»»3





Raaaer, D.I.
Caloccl, ».T.
BaMolblad. T.
(llllaas, I.E.
Plakecsom, c.
1«73
Joacaal of Oceopatlooal
Hadlclne 15(12) :*56-1«3








                                                                                                                                                                                           OO
                                                                                                                                                                                           U)
-------
lead
7*39-92-1
Efc
>t« 207.2. Bt 327.» C, Bf  17«0  c,  It 1.77 u Ho, at 1000 C, 1  m*  B«. at  970 C,  Iff a* H9 at WO C
tISSOl



»127
Kidner























»128
Kidney














«W9
Iver














EIPOSOBE BOOJ




























































alliniCal
BET80D


its
























Electroehen















US















•OTBSB
or USES


a) 9
») 9
e) 11






















1















> «o
) 60
ct 1»













MRGE



a) 0.10-9. £0 ag/g
b} 0.15-0. «» ag/g
c) 0.0093-6.70 ng/g
let vt





















lot given















) 15-517 ppa
) 15-785 ppa
) 0.7- 1ST IPS
sh «t












an* i SEIIBIL iiroBaaTioi
1
1
1
a) 0.23 ng/g I a) Controls
b) 0.34 ag/g I fe) Barker group I
c) a. 29 ag/g I e) Barker areap II
let vt |
Bed la us ( teceasad refinery and anelter
1 eorkers, agea 55-76 rr. exposed to
j keaTy aetals 1-3 decades. liac
I ketveen retirement and death 0-1.5 yr
I In group I aad 2-19 rr, group II.
I Controls, ag«s (3-72 rr. iho lived 50
1 ki froa the factory. S«ed«n.
t
1 SUCK; ClOaTIBS; KIDfETS; LITSB;
I tClSS; COBPIBaim ETLlBaTIOBS;
| IIDOSTIIlt 115IEII; RaSOSZIER
I tir sorts: immni: ustiic: CIDBIDB;
1 C1SIDB; CBI09IOH; COBUT; COPPEI;
1 eoie; iioi; IUTBIBUB: LE*D;
I MieiiESE; BiscvET: •oiraoEWB;
1 IEOSPBOSOS; BOB IBM »: SC1SDIHB:
1 SIlEltm; SI1TIB: TIB; TdlGSTEl;
1 ziic: BEaiTH airiBDS: iroasTEiu
1 flittS; SBIltEBS; TELIHSIOB
1
1
2. »8 ag/g dry vt | lutopsr saaple
1
1 3< yr old utal turner, exposed
( daring a building deaolltlot 3 ao
I earlier. Killed In Industrial
1 accident.
1
1 Itdoalnal ccanp*, constipation.
1 Tcilttna, fatlgaa
1
1 I tit: ma POisoiifG; iioosTEliL
t cisnsES: IIDISTBIII POU.DIICH;
I EtOOP: CISt BISTOBIIS; aOTOPSIES;
1 BEHT; KIDBirS: (EITES; BEIII: B1IIS;
1 Bait; 1ITEB; BOIES; 01IITID KIBGDOB;
1 ICOltS; BEalTH BlZltBS
a) 96 « or - 108 ppa I a] Black adilts
b) 69 * or - 11* ppa 1 b| Caucasian adalts
O «» » or - «S ppa | c) Children
sh at 1
1 latopsies froa hospitals in north and
1 «o«*k Carolina. Slacks anJ
1 Caeeaslaas. Halts, ages K-91 yr.
1 Children, aaca % da fa- 6 rr.
1
I cims; BOIES; LITER: nniETS:
1 HDITS; CBUCBEIi C»D«n3; ZIBC:
1 U»D: mm CUOLIH: SOOTB cieotiri:
1 aVTOPSRS; PIOICCTB011TIOS; IKIaL
1 JTOCIfS; a«Zj SBoniG; TOBICCOS; SEIj
i itonisBS
i
lEniERCE



Brane. D.
Bordberg, G.
•ester, P.O.
19BO
Science of the Total
Environment 1C: 13-35



















Canpbell, S.C.
Seattle, I.D.
Elliott, B.I.
Goldberg, a.
Boore, «.B.
Beevers, D.S.
Tree, R.
U79
lEchires of
Eariroaaental Health
3«(«):«39-»W





Banner, D.I.
Caloeci. 1.1.
BasselBlad, T.
Billiaas. B.C.
Plakeraoe, C.
973
Jonraal of Occepatlonal
eliciae 15(12) : 9W-963








(MIT P1S1)
                                                                                                                                                                                            03
-------
lead
7*59-92-1
n
It* 207.2, n 327.* C,  BP 17*0 C.  TP 1.TT M Sg at 10OO C.  1 u Hg at 470 C.  10 » tg at 1160 C
                                                                                     tconn HID)
tissm

«3«
Itnr




















• 131
Livec














•132
lomg





















iirosnx IOOIB



























































IBlLtnCll
mffoo
us




















Electrockei














IIS





















•OBBE1
or CISBS
) B
1 9
e) 10




















1














a| B
b| 9
d 10





















B1IGI

) 0.21-0. 55 89/4
) 0.39-1.0 ag/g
1 0.28-0. «« *g/?
Set It



















lot given














a) 0.00*4-0.17 nj/g
b) 0.13-0. CC ng/g
C) 0.07S-0.32 19/9
let lit




















•til | 6IHML HTOSBinOI
1
1
) 0.211 ig/9 | a) Coitcols
) 0.63 ag/g | t) Worker group I
c) 0.36 «g/g | e) torter grotp II
let wt |
Bedlams I teceu*} nflnerf a>4 saeltet
1 »cfltet«, a«e« 55-76 jr. erpo«el to
1 >ta*T Mtali 1-3 t |
Xediams | teeeased refimeCT amd melter
1 motkecs. aq«« 55-76 yr, vxpoaed to
1 kta*T metals 1-3 decades, time
1 h«tmm Mtlcememt ami deatk 0-1.5 TX
1 1m gromv I amd 2-19 yr. group n.
1 Ccmtrols. aqem 13-72 rr, >he lived 50
1 ki from the factaxr. Svedem.
1
1 sttiti: cuivns: RIHBTS: HTSR;
1 IDIGS; COBPIBITIW miniTIOBS;
I IIDDSTRIH 1I«Itn; HSISOBEBEUT
1 Bmoss; iBTMoit: msraic: cuaios;
1 cism; cuBOBioB; COBUT; coppst;
1 ooto; »oi; iMtuiOH: HID:
I fiieiiisi; aiBOJBT: MiTSDium;
I fBCSPBO«!lS; BSBIDIO": SClIDlni;
| Sflt«I
-------
l«ad
1*39-92-1
fb
atl 107.2, II 321.» C, BP 17*0 C, T* 1.71 u lg at  1000  C.  1  aa Sg at 970 C, 10 ae Eg at t1«0 C
nssm
•133
1.1*4
«13«
(all
«13S
i«ii
«IM
••m
IXMSIIB tan
labalatiaa


1
uitmcu.
BBTBOD
ladloMtri
Ilectrockea

nectroclea
» «-7I pg
b) »-S a«
lot glTea

t given
mi i 62 HIM ZEroiimoc i HFEIEICZ
i i
i i
»1 30 pg | •) Ifter 23* Mcacol lepositloB of | larro*. P.E.
b) 3 «g I carrier-free PbCW labelled «ltb I Belter, B.
1 »*203 | tuto, F.
| t) Ifter 26* aerosol deposition of | «ibb, r,B.
1 f 1203- labelled ?b(OI)2 | 1910
1 Fictlcl* «iw. SS4B 0.2? » | CericaiMBtal Sewarck
t >««• r»«plr«torr b«m« of tt>2O3, 1.1 | 21:313-38*
1 iCi U a) and t.« tCi i»'b|. |
I I
1 20-5* it ol4«, S5.0-9S.4 k«. no I
1 biatocr of palMncr aiMin. |
1 1
_ i mat wiss: comtinn ITIIO»TIO»S; i
• t IIOOBJ tniiinoi; in toumoi; t
1 (lASOTtHEK IRBODS; « OBITS; IEI TOSS |
59, 5» o»/j Ory >t I litep«T 1 Cupbvll. B.C.
1 1 Mattl*. l.D.
1 I« TT Oil Mtll feWBCC, •XPOMI | Elliott, E.I.
1 tltUt a bvlUi«« a«*olttloi 3 M I 6ollb«rg. 1.
1 «acli«r. Kilted tm iiJutciil I loon, I.I.
1 icclteit. | BMT«». 0.5.
t 1 Tree. B.
1 Ibtoeiul ecups. coutipatlo*. I 19T9
1 loaltlia. fatiam | irchl*«8 of
1 1 tB»iroB»e«t«l Health
1 met mo rcisoins: mosniu i 3a|6u»39-««3
1 cxsMSES: iierartiii POILOTIC»: i
t HooBi cisi nsTonis; »oroest«j; i
1 HUT: (loins; nuns; aim: nits: i
1 IHI; UTEl: BOIES; VIITIB MISDOI; I
1 ItVlTS; BE1III BlZlIVS 1
1 |
I |
t 1 r«ri«* af rorld llt«r«tor« o* ttt I Jttkltt, I.».
I aecualatioa a«d bloeaioeBtratioB of I 1*19
1 s«l«et«i toxic trace i«tal« la KUB I Eri-COO/«-79-0*». 18*
I kiic a>4 Milt t>4 otker MmBaliaB t PP.
I hale, far, mil*, cUva tad boots. I
1 Tit»l«t«« br vcoorapble area, 1
1 aablects. *ei. a«*, expomra I
1 ara41*at, aailravs la pp», aid I
1 tatboritT ftci over MO refermca*. I
1 I
I «mc»: ivsTiu.ii; CUIDI; cmiu i
I iiiiicij CT»CTt; irtim.i cast; m i
I tium; SOBTB usiict: sonnasT i
I ISIl; »n*D IIISDOI; OKTlt ST1TIS; 1
I tut; tans; BtriCT: atriBon; t
i iisEsic; soicij cunn9i cncnim; 1
1 ccsiti: ccprii: LHO; Biscni; (
i iicm: sntinR: HI; THIOHHJ ui i
i icttotioi; imu MraLiTiais: i
| BieiCCimtlTIOfl STOTICTCltOK; till I
1 tcumai; porounci BIPOSHII; IITR I
| fCltintOI; TUCE ItMIITS; BET1IS I
1 1
.*« ag/} drr it 1 l«tcp«T *aipl«. pettpkeral »«r»e | Caapball. B.C.
1 | I«»tti«, 1.0.
I 3C TC oil Bttal tittaec, expoMl I ClUott, I.I.
I 4»U« a bnlUlaq AMolltloi 3 mo | Goldberg. 1.
I earlier. Killed IB ladwtrlal I Hoore, B.t.
1 aceldmt. I Beever*, O.G.
i 1 Tree, 8.
1 Itdevlul ctaipa. eoaatipatioa, 1 1979
1 tcaitiaq, fatiiM I Ircklvu of
1 1 EBTlronM*tal Healta
I HID; mo MISOIITC: iionsniiL i 3«(«):«9-«»3
t cisMsts; mgstitii pounioi: i
| IIOOI: CISC HSTOtlEJ; IOTOPSISS: I
1 inn: Ktvins: IHTM: etui: »iis; t
| lilt: UTtB; BOIES; H1ITID ttlGBOS; I
| I1I11S; K1H( UUCDS |
I 1
(•in t*s«t
                                                                                                                                                                                         oo
-------
I«a4
ft
Itf 207. 2, «P 327.* C. It 17*9 C, ?P 1.T7 •• •« at  100» C,  t  •• lg «t  97« C. 10 n If at tlSO C
«««•»



• 137
Sall»a









,„,
Srlaal
eoct











1139
TMtb
















««0
Math
























irosvti toata



























_
lakalatlo*

















I*g*«tio»
lakalatloa
























klltmCaL
BCTHI


US










J-ral spectra*













US

















us
























nnn
OF CaSBS


at
11*
31
33







) 7
b» 12











.
al 3*7
b) 323
cl 690
11 597
•t M













371
























•net



lot glv«n
lot gl»«a
lot gliea
lot gi»ea







1 11.2-113.0 ag/g
1 C.1-3I.C ag/g
Brj «t











a) lot giro
bl lot given
c) lot given
a) lot given
•1 lot given













a) lot glraa
b) lot given
c) lot give*,
d) lot given
•I lot gt*«a





















U*f 1 Canm irVOtltnOW
1
1
1

1 «J.2 «g/l | b) totter*, *teel ladaxtry
I 94C.3 »g/l I el aorken, battery factory
I 2220. S ag/1 I d) corker* . ncortary Pb aaelter
^
i 17-C3 yr oia caacaalua
1
| ClllBk; a WITS: BLOCB; SUIVl; n
I TITO imisiS! KID: HTHS;
| CCCOPKlOIll Bit UBS; g«LTC>S
t
a] *J0.7 « or - 36.7 I at lotoc aaacoa OlMaat* patlaat*
•g/g | bl Coattoli
b) 1». S * or - a.7 | Imtral kotn tlainc, aatopa)
ag/g I
Dry at I f atUata aial of ayotropkic lateral
I *claro*l* aa< progr«aalT« aucmlar
I attopby, a«a* aq«. 58. « » or - 13. 1
I ft- Cottnli 4i«l of yaclona
1 aiaaaM* at C0.9 « or - 11.1 yr.
1 mis: isoiTS; konmisi
| ItUtOSTSCOUS DXSIaSIS; Smal OOBV;
1 iiokccnmitioi: cticias: coppst:
| HOli HID; IU6UESI] SITU.S-.
| SttBVlQBs X1IC
1
a| t.77 ag/g dry « | 1} Boyi. lr«l 1
b| 4.9* «g/g 4ty «t I t| 61rl«, Itaa k
c| «.»7 09/9 dry wt 1 e| Ban aad girl*. Ina 1
41 *.92 ag/g dry «t 1 t\ ChlUcea Uvlag 1m kcea I slaeaj
«) 3.0* ag/g dry «t 1 ilrth
1 c) chlldrca. ar«a a
t Ina 1. kcavilT Udntr'lallnd city.
I IMB S. aabacban/raral area
1 Coacmtr at to* lacraamd vltfc ag«.
1 ».6VTt.
1
1 Qaraas ?-T2 yr olii. llvlag la
1 BalBbarg, lakrdlatrlct ail
1 Cuaavrsback, B*xgl*eha> laad.
1
1 tnnnt oiium: TBSTB:
i iioiccvmiTioi: mosmat
i i«issto»; neu laiis-, IHB
a) 32 ag/g 1 it Tr«at«d •acapbalopatkr patleiti
bl 29 ag/g I It Traitad Pt-polsoalig patient*
et 33 «g/g I c) Vntnataa aablactB with klgk
d) 58 ag/g 1 blood, kigk or leu tootk Pb l«T«la
a| t2 ag/g | at Qatcoata4 aab^acta vitb low blooa«
Mk «t I klgk tooth PI 1«T«1*
1 «) VBtraated ambloctai ulth la* blood.
I lo« tootk Pb l«T«li
I
1 Chlldraa la Pb raglctrr of iy city.
1 ilUlag* o( toqictry cas*a aad daatal
1 clinic satlaats. Host trace black.
1 yc. a«m 2.3 yr.
1 Rigfc laeld««c* of p*yekologlcal
1 nfarrala ail behavior problnc la
1 a), b|. e|. CoBTBlcioas la •
I tatlaats. » «f * •keaphalopathy
1 patleat* MBtally retarded, BOB*
1 atagaomd orqaalc brain ayadroae or
1 Mine* llsoiiler*.
1
I itit: inns: cuiisM; nt
1 PoitTtio»: inr ton: ami rcisonte
l tiBMios nsdoiis; imi9>iio«:
I EiooB: fiRit tuns
i
nrainci ' '



*•». l.I.S.
981
Jovraa.1 of toxieolog}
aad VeTlrobBeBtal
Health 1: 273-2*0






Karlavder. H.B.
fattea, l.a.
1979
lanal* of 1C* urology
M^l >21~2k









Smta. B.
Brockkaos, l.
Sentec. S.
Schvraau, I.I.
1979
Intenatlonal archive*
of Occupational and
Enrlroowntal Bealtk
«*t«5-80









klbert. I.e.
Shore. I.E.

strehlo*. *cl
SBelp, T.J.
Pa»t*rnack, 3.S.
Trledkoff. l.J.
COI1B, T.
Cialao, J.I.
197*
laTlronHBtal Health
r*npeetl*es 7:33-39














HUT ««)
                                                                                                                                                                                              00
-------
7439-92-1
Ft
It! 207.1. IP 327.* C. B* 17*0 C, TP  1.77  a*  8?  at 1000 C, 1 •• Bg at 970 C. 10 •• Bg at 11«0 c
                                                                                      (comma)
1XSS01
4141
Urine
4U2
BClM
*1«1
mine
41*4
Urine
•14S
Hri*e
Birosun BOOT
Ink*, lit! OB

(Oestion


IBalTCICM.
BRBOB
IIS
us
BS
US
T
•nails
OP C1SB

«| S9
b) 77
C| 51
d| 70
*
32
7
22
2?
10
II MI
8-40 «g/l
•) 11.6-15.4 «g/I
b) 4.1-12.6 mg/1
e| 8.0-9.6 ««/l
d) 6.C-9.7 «g/a
-
27-38 s«/d*r
1.3- 16 uol/2« ir
0.»-1.5 iBol/24 kr
lot 9iT«n
lot girt*
lot given
Sit I | Gtllttl XIPOBB1TIOI I BmgEBCE
• 1
16 «g/l | 20 aaaples i I*g«*son. T.
1 Direct deteraination and attraction 1 Indrasko, I.
j troc«d*r*s agree, j 1971
1 1 ClUical Ckviistcr
1 »«ld«r«, quiq* p«c«o*D«l aad putty 1 25(11) :19»8-195J
I *crk«c» In s»«dt»k airpl«>« factory. I
I 1
| IICOSTBIlt fdlVTtai; COBMB1TITE I
| (TllgiTIOIS; ClBBinU; SVIDEI; IDULTS; |
i BIOOD: nnt; BIOICCOIOIITIOI i
t i
*t 13. 2 a«/l | •> t«l««. 10* l»aele> 1 jotason, B.B.
b| 10.3 ag/1 | 11 ?«•«!•«. toa lo««l«« | Fravost, H.J.
c) 9.0 mg/l I e] B«l««, Koetatcr I Tillarf. J.B.
4) 7.8 na/1 | i) P««»l««, U«c««t«r | Ca««nn. D.I.
SoOMtCiC •MB» | 1 ROMBfeld. J.B.
1 Californium ll*li« 4an«in< fro* • 1 1976
I fr««*T In 10* i*4*le* or 1* th« high I eEl-«00/1-7C-019. 235
1 d«««rt rcqlo* of l**c**tcr. »j« 1 pp.
1 groapa: 1-16, 17-3*, 35 or »or« yr. (
1 «fl» *Ut«. «M ioi-«ttte i* lo« {
I l«g*le*. 90t *Uta, JW oon-whito 1* 1
j t«*c**t*r. i
1 1
I KlllS; niTXIBB; PUUDIOfl: LB1B; 1
| EOPOUTIOI ZIPOSHZ: OCCDP1TIOM1 I
1 Bitiits; ctiiroini: toropsnsi i
I HOOD: KiDirrs: spiiiu am: mat; i
1 miss: inscizs: ADIPOSE Tissue; i
| IITH: COBPIHTin millTIOfS; •!« 1
1 JMSIT: cmti: sums: imOHOtivs i
i i
I i
32.75 ag/4*y I Iicntio* «od«r **liia>t conditions I B*al*o«lti, B.
( <«nfilt«red alrl doriacj 41-124 a*r* I *eth*rill. l/2« he | r| Controls | Doss In  goat, 1 landy, :.
I tc prior Pb «rpo*ore. I fedeen, E. p.
1 1 1991
1 32-78 yr old qont patient* | «e< England Jowwl of
1 1 Bedicine 30»(9V :520-523
| •« Jt^5IT; IOH1TS: KID1XT DISEaSSS; 1
| licet; 1IT11; if» |
I 1
                                                                                                                                                                                          oo
                                                                                                                                                                                          oo
                                                                                    (BUT IkBI)
-------
lead
7I3M2-1
ft
Itl 207.2, If 327.* C.  tt 17*0 C. TV 1.77 mm B« at 1000 C, 1 as Ho *t 970 C,  10 ••  B?  it  11S» C
                                                                                      (COITXItrZDI
xisss]
414*
«Cl«e









BUOSVIB IORZ











nimiciL
BBTBOD











• OBEBI
OF C1SK
93










tllGI
a) 2-230 «g/l
b) 200-4500 »9/2» br
c) 10-170 og/1
4) 200-4300 ng/24 hr







IE* I
•) lot giiaa
M lot givaa
e) let glvaa
d) lot gi»en







GEIZlal IirOKBkTIOI
•1 loachelated Pb, la 48 vorlwc*
•ipoaed at least 1 TT
t| MM-bouad Pb. la ijroop (a)
c) ioneti 31
b] 22








SalCl

0.20-0.61 eecj/1







a) lot gl**a
b) lot gltea


















a) lot givea
b) lot «!*••








Bill

lot applicable







a) 0.78 « or - 0.01
aeq/1
b) 0.48 * or - 0.01
aeg/1
















a| 0.22 ft*
b) 0.40 ppa








S11ZUL T1TOBMTIO1 |
1
faage of Maas
Dose, SO 0-500 ag/dar as carbonate.

Depressed patients

iniTDa: BLOOD f 11311; BZTU5:
CBimmitpT; IEIVOVS SISTIS DISUSES

a) laasas City, IS, bard-«ater area
b} Kaasas City, BO. soft-sat«r ana
SigalflcaBtlj higher lerel (f<0.01|
!• bard-cater area.

IS aad BO r«si.d«ts satcbed for age
(Mat aoaa 37 and 37.7 yr> . m.
leaotb of rasldeaoe. aarltal aad
eeoaoaie atatas, oecvpatioa, Basber
c( chlldt**. uoUaq habit i. hi, *t.
la bard-«at«r area, significant
itexaaa* 1* hivertemslen, VX
ataoraalillts, aid bTpomiccsla.
ciHU: iissotnii; .DHT.TS:
ClltlCTUCniK DISHSSS:
BIPTITI13I01; BLOOD SI BOH;
ciicna; ciicBTDB; LITBUJB:
BismiiB; pHosraoBOns; rotassioi;
SCDim; me; BIO1CCTF5U11IIO*;
ISIKHS vitn
a) learalag disabled
t) coatrela

learalag diaabled aad aoraal 3rd aad
4th grade stadeats la Caaada.
cmciuB; BiGitsun; potissms:
sconi: ciDaiDS; COBH.T: conn;
:«3i: L«III; uiGinsE; tuc;
c»onn; mnoB; azsonti; BRU.S;
itTi: cniufii; CMIDI
BZTEBEICE

Balliager, 1.6.
Balllager, J.
Rlaialhocb. J.9.
(ell. J.P.
Baain, I.
1990
PBrchopbaraacologr
68: 249-255
Blecaaba«a, B.L.
TlelacliBaa, I.I
Doan, J.
Irhald, J.
1975
laacet
1 (191*1 -.1008-1016













Pitil. 1.0.
?»k*e, 1.
1977
Scljeace
199 (4313|.:204-206





                                                                                                                                                                                             oo
-------
 n-Pkenrlenediuine,  (-Mtkoir-  (8 CI)
 1,3-EeaZelM«iaalne.  *-netkOII-  (9 CI)
 C 15-05-a
 C7-110-I2-0
 II  138.1
HSSBS
• 150
Orine







I
I
Hfosm ions











iiiiTticu
IRBOD











•ram
OP C1SSS











SUSS










1
on









1
1
sunn moBimo*
SeTle*. local aaa STatenic effects
relating to kale 4ye fornulation.
iigccdint t««ts. aad «rp«ri«nc«« in
MI »nl iiliali.

KBITS: niBiWius: Ropiisgs; asm:
I* T2TIO IIHTSISi II TITO 1I11TSIS;
t'TIIt; OTIS; CUdlOGZI; COSHBTICS;
siimc inters; BIHTH gizmos;
•RlBOtlSI; 8R1B01ITBS

U7IREICE
Banolli. r.I.
erces. s.
Mibach. H.I.
1«7«
Journal of
ZBTiraaiental Pathology
and Toxicology
1:589-530



l-lolgaiid*. I,f-di«tkrl-  (I CI)
(•nuiid*. l.f-U«t1iTl-3-utkrl-  («  CI)
13»-62-3
C12-B1T-I-O
II 191.2C. Bf <2S C, BP 160 C at  19  u I«.  Ill  C at  1.0 mm aq
1ISSOI
• 151
Blood










znosots BOUTS
DKWl










nil men
HBTBOD
8C/HS










BOBBIE
or cists
i










«»»«s
lot giT«n










111 I
0.3 ag/100 •!










CBBIML IIFOBBITIOI
8 kr after application of 10.* 9 of
DIR (133 KJ/tl) in a coiMCcial
i>a«ct repellent to about 75* of skin
aicfaee.

30 IT oil, lit 78 kcj

OltTBD ST1TM: 100ITS; B1OOO; BUWK;
nsnciais; n TITSO IULTSIS



nrzKwct
la. 1.
Pearaom, B.l.
Skekoski. 0.1.
Soto, B.J.
Stevart* B.l>.
1979
Joenul of High
Sesolation
CkTOMtoacapky and
Ckronatograpay
Coennn icatioos
2:«8-5«2
                                                                                                                                                                                             VO
                                                                                                                                                                                             O
-------
a-iTi*» ca en
!*>«••. 1,3-4i»«tafl- (9 CI)
HI-38-3
Ct-110
ii we.it,  n -47.4 c,  TP n •• Bg »t 21.3 c
tissn
4152
Blood
4153
Blood
IIS4
Hoot
MSIM BOOH
akalitloa

lualatin
iHimcii
BIT BOB
OC
ec
ec
io»n' i UKI i Btii i eiiEBit IITOBRUIO* i umncz
or cisis ill I
iii i
III I
I a) lot gin* 1 a) 8.2 » or - 0.8 1 a) Boiaay «-•-. «o*k 1. air 1*T*1 4.1 I SarolalM*. E.
I b) Bet giwi 1 uol/1 1 »oVl 1 BtlkUaU., T.
I c) Bat gim 1 b) 9.9 » or - 1.6 1 t) Roiday p.*., Mok 1, air !•»«! 4.1 I linaoila, R.
1 d) lot gira 1 aaol/1 I uoVl I 1*7*
) o) lot Jim I et 1D.6 * or - 1.5 1 c| Friday a. a., iwfc 1. alx !*»! *,2 I Xatcraatlonal lr£kir*»
I f) Bat gimi 1 aaol/1 1 •»1/1 | of Occip»tioul ud
I g) tot gira 1 d) 19.9 * or - 1.C 1 d) Friday p.*., ***k 1. coaontratioa | nvtroiMital Beam
| I a oo VI 1 ii ait Ural 8.2 uol/1 1 44:201-211
1 1 •) 8.7 » or - 2.1 1 «) Boaday a. a., cook 2, air lOTtla 1
| I »ol/l 1 llietiatlia. it 4i 1 «nl/l 1
| t tt ».4 * or - 3.* 1 f) aoiday p. a., wot 1, ale !•»«!» |
| 1 uol/1 I (lactutlig at 4.1 uol/1 |
| 1 A M.I * or - 3.2 14) loawiaai p. a., «o«k 2, air lerol I
t 1 1 I
I | 1 at 1811 ca, MI rt 70 k. | BaTiroiMStal E«altt
111 1 43:154-150
1 i i cccoriTiOMt iMitis; «EBBIIT; i
1 1 1 ItUlTS; HOOD; CatCIlOCI* 1
1 1 1 1
III 1
» 1 a) Bot gl»«i 1 a) 21. « * « - C.3 1 a) Trutmt Say t, ooastaat orponn 1 aanlalna, C.
1 b) Bot »1»« 1 «aol/l I lti«l (3.1 niol/U ( tllliUaU. T.
1 c| Bot gifn I b) M.7 * or - 27.S 1 t) 1roatn*t day f. ooastaat exponro j Soppalaiooo, t.B.
1 at lot gim 1 aaol/1 I !«*•! (B.2 «al/lt 1 liuolla. R.
1 •) lot gim 1 e) 29.5 * or - 4.2 1 c) Tnatcat day 6, following 2 1 HBO
1 f) lot gim 1 nol/1 | mitmtmt day*, coistaat »ranr« 1 Xitanttloul ltcU»«i
1 1 dl S1.0 * OP - 2.4 llml (3.7 uol/U | of Oceapatloul ud
I 1 «oVl 1 d> IroatMit day 1, fariabl* oxpomn 1 iBTironaamtal g«altk
• | 1 •} 117.3 * or - 23.8 | 1««1 (tiic-Mlgkcod avorag*, 3.8 1 49:105-121
I 1 uol/1 1 aiil/ll |
I 1 t) 48.1 » or - 18.2 t«) Troatnat day 5, variable oxconro I
I 1 uol/1 1 !•»! (tloo-Migktod avoraq*, 7.7 I
t 1 laiol/1) |
I 1 If) IcoatMBt day 6. follmiig 2 1
) t 1 ic«tx«atM«t days, variant* oxponcc 1
1 1 I ICTOI ItiM-Migktod anragt. 3.8 I
1 1 laaoVl) t
1*1 1
1 1 1 (.tilth? wlntMis. MU ao*« 23.* * 1
1 1 let - 1.4 aid 24.T * or - S.I Tr 1
1 1 * 1
1 1 1 Iipairoaat of body baluc*, raactioa |
1 1 1 tlati, aamal coocdtMtioi, and 1
I 1 Ickaogos ID EM. I
III 1
1 I irnuit; nous; noon; CO»UHITI i
1 1 1 ItlLUKIOlSj BBnniS; IBBUtTIOir 1
1 1 1 1
-------
 a-lTleae «8 CIt
 tBBSeae. 1,3-dinethyl- (9 CI)
 108-38-3
 CI-110
 B«  108.16.  RF -»7.» C. TP 10 » Kg at 28.3  C
                                                                                        (COIfllOBD)
1ISSOE
«15S
Breath













ZXPOSmS BODTE















1BUTTICU.
BSTBOD
6C-BS














mates
or CISES
54 (387
sanples)













B»«I
•Ot given













1
Bill
0. 32* ng/1
Se one trie













GEBZBal IBFOBRaTIOB
leasarcd at 25 C aid 760 as Bg
15.81 occurrence
lower and vppar one-sieBa liaits
0.0*5 a«l 2.32 agyl

Htalthy, 18*95 yr old, nonsaoklag.
at tan blacks ud caacasiana.
Chicago, n. Bigidly controlled
•ipcrlMital canditiona.
IIHTH; IICOBOLS; I III 101 S; 1DOLTS;
CKCBIMTrD BIDKOCtlBOIS; TOlltni
C1GIIIC COIPCVIDS: BZUTB HlIl'BS:
iiBit»iof; mrr»Bonss: HJTIEOLITBSJ
fCPOUTIOI (IKS01T; OSB»I JB11S

IBFKSKBCB
KrotoszTBski, B.K.
Brnneso, e. R.
C'leill, B.J.
W79
Journal of Inalytical
Toiicology 3:225-23*









lagnasioi
1»39-»5-«
B«
l«l 2*.305, BP 651 C. B? 1100 C, TP  1 ••  Hg  at  621 C.  10 u Hg at 7*0
tissnx

*1S6
lorts

















*1S7
Elool


















EXPOSOBS BOm








































tliLTTIOl
BETHOD
U






































HOBBIS
OF C1SES
2






































BIISI

110-860 ug/g (vet it)


















a) lot 9iT«n
b) Rot git ft
c) lot giT«n
d) lot giTeo
ej lot gi*CB
f) lot given














BEaB | S1IIBIL IBTOSUTIOB
|
1
•90 » or - 530 og/g I tales
(»r chives of
Invironaental Health
3S(1):3«-«*











CockbnrB, F.
Bel ton, U.S.
P«rris, B.J.
eiles, R.B.
Erovn, J.I.
Tamer, T.I.
MlkiBson. E.B.
Forfar, J.O.
Barrie, W.J.B.
BcKay, e.s.
Pocock, S.J.
1980
British Radical Journal
281 (62 32): 11-1*






                                                                                                                                                                                            VO
                                                                                                                                                                                            NJ
                                                                                     (BEIT VISE)
-------
7«3*-SS-«
             '  e;i  c.  » 1100 c, TT t •• B» at «2i c, 10 » t« «t T«O
HSSB1

aiSi
Blood,
sena






















Bra Is



















• ISO
Bail











xrosniB soon
























































1UIYTICU
HCTSOO
US





















u




















IIS











•mm
or Casts
2«0
2*0










































a) 31
b) 22










llKI

lot gi»e«
lot «lrei





















a) 79-»OC aq/g (eet «tj
b) 100- »«0 »g/g (wet it)
c) W-329 wj/g (wt *t>
d) 57-2(0 ag/J (vet >t)



















a) lot give!
b) lot glrea










mi i stum IBKHBIIIOM
I
2.01 » or - 0.01 I a) (ansaa City. IS. hard-vater area
eoyi j ») Kansas city. BO. aoft-»at«r area
1.41 » or - 0.01 I Slqalfleastli Ufaec leral |«<0.01)
net/l | i« aard-vatei area.
t
j 13 an* «0 rttfdeats aa toted {or age
| flea*. a«e* 31 and 37.7 ?rl , *ex.
I lasotk »f resideaoe. aarital aid
j eeononle itatu, oceopatioe, naaber
I cf children, saoUoq iabltm, it. *t.
1
1 la haro-mter area, Blanificaat
I liereaae i> hfperteBSlon. ICC
I ataorealltles, a ad hrperacicasia.
1
1 inns: itssOTBi: »ntsi
| CISIIOTIScatUt OISK1SSS-.
1 E1PMTH3IOI: BIOOD SJBOB;
1 CCRPIHTI^I nuonms: CIDBIHB;
1 CIICIHR; cRtcRioi: iirRim;
I BiGixsiBS; tftosrcosoos: pOTissira;
1 sctmni; n«C; BioiccoiiouTiai;
1 HIIKIIS urn
i
a| 210 • or - 100 t a) Bales, ceiebraa, t svbleets
99/9 (••* «*) 1 " T«aa«s, oerebru. 2 rabjecta
b) 270 » or - 2*0 | O Bales, cerebellea. & BBtjects
ng/a (>et »t) I o) Feiales, eerebellu, a aabjacts
ct 170 » or - 8S «g/q 1
(vat *t) | tioa a <|roap of Cl antopciei.
d) 170 * or - 90 H9/9 | forensic eedlcal aiaalaatloaa, Japan.
(•et «t| 1 (ales, aaan aq« ao.« jr. feaales.
j aean a<]« 37. * jr.
1
I TI1CZ nZHniS; IBTOPSIES: JIP1I;
1 HHRIIOB; iBsraic: CIBBUJB: COBU.T:
I cticmii; cop»!B: ZBOI: BCBCOBI;
| 1I9IUR; RIOBISIDB; RIIB1BZSI;
1 lOCIDIOB: HBTI10IT; SCITOIOH;
1 ittzilll; TI1III01; TIUBIOH; {IK:
I ectt: asonzBt: IIT^B; KIDBI^S;
t CIJIBS05; CIBEBZUOR; HIIBT; ROSCIES:
1 iHcnu: stii»i miss; xcsii;
I iniis; coKiiBinrB STILOITIORS: sn;
| IOBIBSIC HniCIRE
i
1
a) 35 ppa | a) I«anla9 disabled
b) 37 ppa 1 I) Controls
1
1 I«ar«l»BBB. J.
rnold, J.
97S
aacet
(HU(l100«-10U

















Taka«a, B.
Seiaki-TasuBOto, a.
laaBo, E.
Tarai. R.
1980
IrehlTes of
Eailronacatal Health
35(1);3*-aa















Ilbl, B.C.
Parkes, B.
1977
Scieace
198[»313) :20»-206







(HIT FUSE)
-------
1439-9S-4
»9
Itl 24.30S, ft 6S1 C, 1? 1100 C. Tf 1 M. Iq at 621 C.  10  •• tg at 740
IXSSBt



4161
Batr



















1162
(•art
















416)
Bairt









4164
IUMT



















EMOSBBC ion









































































_«__________
111LITICU.
BXTBOP























U

















US










a




















BOB an
or CISBS























at 4
W 2
















) 14
I 7









£
2

















1

MBS*
























a) 87-420 (9/9 (*»t »t)
b) 110-320 «9/9 (a«t at)
















) 94-246 09/9
| 197-251 S9/9
at »t








53-250 «9/9 (Mt vt)
57-130 49/9 (aet at)


















(am
1MB | CIBIU1 IBFOBB1TIOB
1
1
1

I prs-aaalysis treatsests ara
I tabulated, tha faasibilitr of a
| holistic. BO-vash policy for hair
( (Hirsts Is oatliMd «aJ sspported.
i ftvisB; TBtci Ennui; am:
I 18S1BUI1; BZISBBIBSBT BITBODS:
1 itTalSt PtoiHIS; COWIBITTO
1 tmoiTiois; aLBRiBim: iBrnowr;
1 nsmc: BMIBB; BBOBIBE; owios;
| C11CIIB: CB1CSIBS: CBKOBIOB; COBALT;
1 ccrtn: siiitvit; ennuitia: «jio,-
1 lOBMI; MOI; Ll«n»IOSj iBIt;
| BaSBISIOB; B1BSEBBSI; BBICOBT;
1 tcimravi: HOCK: ttosttovas;
| IOIMSTtl
-------
MgM*ill
7«3f-*S-«
«9
Itl 24.305. a* 651 C, IP  1100 C, n  1  u  14  It 62t C,  10 u BiJ at 740
1IS3H
»1«5
lllOX
• U«
l«»9
»1«7
luclo
nosnc «cim



tlURXCU.
BTTIOO
U
U
11
nnsi
or cisis
10
3
a) 2
t) 2
a) *
b) »
tllGX
1 37-750 ag/j |«*t «t|
1 M-200 »g/« (««t vt|
•) 79-150 «g/g (»ot »t>
I) 86-110 ag/g (««t >t)
*| 130-180 «g/g <»t «t|
b) 82-500 o-)/g |Mt »t|
1111
) 2*0 * or - 210
g/g (net «tl
) UO » or - 83 «g/g
•«t »t)
-
a) 110 * or - SO oq/9
(wt «t)
b) 98 * or - 17 ag/g
(»ot «)
a) WO * 9t - 11 n«/i
(«»t lit)
b) 230 « or - 1(0
ng/g (»«t »t)
cciistL MToismoi i nnmci
i
i
i
a) lain I Tokaw. 1.
t) T«m«l«B | sazakl-lanuto. g.
1 lino, I.
Jtoa » qro*p of 61 aatopii**, I Tcrai, 1.
female itdlcal •xailoatioM, Japan. I 1980
Balw, Htt aq« *0.« it. T«ul«s, I lieaif«a of
a«a» aq« 37. « rt. I miconnatal B«alth
1 35(1lt3«-M
t*»cf mints: inoMiis: j»i«; i
lUBim: ttsmc; cuuoi; COBUT: i
cnonai: ccmt; noi: incint; i
iiexiiii iisiisioH; UIG»I$E: i
HIIOIH; IHIBOJl; SCIIBIDSJ )
si»ms; Tiunoa: mioin; znc: i
6C1B; noun; inn; noiirs; i
citintn; ctitBium; m»: anscus; i
(IKItlS; Stini; 1D1SS; Mm; |
erru.it coiFit»in CTIIDITIOKS: sii; I
fCSIISIC »tICI» I
1
1
•) nalas ( Taka«t, R.
t) »«aal«« | SainU-UMKrto. a.
1 l*aao> I.
froi a IIOIF of (1 »topil«i. | T*r«l, I.
loc«asic Hdlcal uaalutioit, Japan. I 1980
•aim, aora ago »0.6 rr. Tonlos, I &cchl*«> of
!«»• ago 37. < TT. 1 Ea*lroMoatal Baaltk
1 3i(1)-.3*-»»
11 1C! ILlBtllS: lOTOKItS: IU»; |
iiomii: itsmc: CIDBIDB: COBU.T-, i
cBioaii": ccmi; itoi: incnti: i
iicuja: neiism: UKIIISI; i
mtiBitis: innon; SCIIBIBB; i
sntnvi; miiioi: wnoiti: zi«c; i
son-, Btogiit: Lint; ng*ns: i
CIBI3IH1: cnsBxiiOB; nan; aosciis; i
iiiciEis: siim: inesi aoiri: i
RtTUS; COHTIUTin MliO»IIO»S; S!X; 1
retnsic itBicin i
a) lal«s | Tnka«a, 1.
t) Toialoc | sanki-Tancoto, S.
1 aaaao. (.
ftop a gronp of £1 aatopaios, I Torai, I.
forma le Milea! oxaaliatiou, Japan. I 1*80
Stiff, fffa ago »0.6 rr. loialos. I lreki*«s of
a«ai ago 37. » re. I nrtcomeiktal Health
1 3i(l):36-a»
i»ce niMRS; mopsiES: Jirii; i
UOniDl; I.B3J1IC; CaOSmS; COBILT; |
CHOHItri; COPPIR; itOR; BI1CDBI: |
ntwa; aisusioa: uneivtSE; i
BVBIDrra; 1RI10BT; SCI (BIOS; f
snifin: TiTuioa: TIBIOIO*; zi«c; i
ecu: notin; iifn; UIMHS: i
CIBIBB11; CtBtBEUVR; HHBI; SDSC1IS; I
lucitis: siuEi; LUISS: icsti; i
BITIIS: COHIUTIVX zfunmovs; six; i
rcinsic fiiciciBE i
i
                                                                                                                                                                                              Ui
                                                                                         (HIT PIG!)
-------
Bagnesiva
7«3»-9S-a
Its 24.305, BP 651 C. BP 1100 C,  TO  1  aa  Bg at £21 C, 10 aa flg at 740
                                                                                       (CORIKIEV)
HSSflB
4168
Pane rets
«1«9
Spleen
4170
Teetb

BIPOSBBE gOUt




AIALTTICAl
HBTHOD
U
U
US

BOHBEB
or cisis
«> *
» 2
a) 5
b) 3
» 51
b) 10
) 10
) 26
) 11
O 51
I 10
> «8

BAIGS | Bill | GEIItll IIVOBIATIOI
1 1
1 1
1 1
a) 210*350 ag/g (vet »t) | a) 230 * or - 70 og/g | a) Biles
b) 260-320 og/g (vet vt) I (vet *t) I 1) resales
1 b) 290 * or - «2 ag/g I
1 (vet vt) | fro a a group of 61 autopsies,
I j ferensic aedical examinations, Japan
I ( tales, eeag age 00.6 yr. resales,
1 I Han age 37. • vr.
1 1
I i »>CE niRzns: ADTOPSIZS; JAPAI;
i i AioRiiDR: itsmc; caomna; COBALT;
I | CHOBIU5; CCCPEB; IBOI; REBC0BY;
1 i iiDim: msiisiDB: RAIGAIZSB;
I i BOBiDios; AniROii; SCIIDIOS;
1 i siLMWR: TIT AII DS; VAIABIOR; titic :
I | GOLD; BBOBI«I; IIT1B; KID1IIS;
1 | CIBBBBUB; CIBtBniOR: BE»BT; B03C1IS
1 i nicBEis: SPICT«: LORGS; *OITI:
1 1 BITUS; COIPU1TITS ET1LV1TIOIS; SEX;
1 1 FCB'ISIC BIBICUE
1 1
1 1
a) 120-560 ag/g (vet vt) I a) 230 » or - 190 I a) Bales
b) 65-580 ng/g (not vt) I ag/g (vet vt) I t) males
( b) 320 « or - 260 I
1 ag/g (vet vt) I ftoa a group of 61 autopsies,
1 | forensic sedical exaainations, Japan.
1 I Rales, aeaa ag« «0.t rr. rcaales,
1 | i«an age 37.4 vr.
1 1
1 | TB1CI fllRIHS; aMOPSIES; J»P»»;
I | IIOBH11; 15SBBIC: CIDSIUB; COBUT:
1 1 CGICRIUR; CCPPEB; 1B01; BEBC08T:
1 | IRBIHB: RiGirsiDi: aiienzsi;
1 1 IDBIDIM: HIIHOII; SCHDIBS:
1 1 SII!»I1B; TII11IOB; TalASIDR; ZIIC;
1 1 GCID: BBOBII!: tlTES; KIBHHIS:
1 1 CIBIB55S; CIBBBItDBt HE1BT; ROSCLIS;
I | S1ICBE1S: SPIZER; IDIGS; JOBT1;
1 | a!T»LS; COBPaUTiri ETH01TICBS; S!X;
1 i res-isic gzticzit
i i
) 2-5 mg/q | a) lot giren 1 a) Iiaael. rural area vita < 13 ag
) 2-3.7 sg/g I b) lot gireo I Hg/g soil
) 2.3-3.5 ag/9 | c) lot girea | t) Eaavel, rural area vith 13-19 ng
1 2.2-3.9 *g/g I i} lot given I ag/g soil
1 6.5-8.1 ag/g I e) 7.4 » or - 0.3 1 e) Znaael, coral area vith > 19 ag
I 6.8-9.1 ag/g I ag/g I Ig/g soil
1 7.2-11.1 ng/g | f) 8.8 * or - 0.2 1 d) Enaael. arban area
5.8-9.1 vg/g I sg/g I e) Dentine, as in (a)
1 g) 9.0 » or - 0.3 I f) Dentine, as in (b)
1 ag/g \ g) Dentine, as la (c)
1 h) 7. 1 » or - 0.2 | b) Dentine, as in (it
1 aq/g 1 Ktiiated fres graph (a-c)
I | Iqt dependent data also presented
1 1
1 I fesldeats in Finland
1 1
I i Tinuo: «st : sai; TEETH; COIPIMTITZ
I i !t«m-io»s: ueizsiin; zuc; SOBIL
I i mils: ntsii asiis: RETUS
I i
(IZXI PIG I)
BIRBIICK
Takava, H.
Sn-nki-TaEanoto, R.
Aaano, K.
Terai, R.
1980
Archives of
Envlronaental Health
35(1):36-aa
Takava, H.
Sa-aki-Tasnaoto, 9.
laano, K.
Terai, 8.
1980
Archives of
Environmental Health
35(1):36-aa
lappalainen, B.
Knaottila, R.
Salsinen, B.
1981
Archives of Oral
BlologT 26:1-6

-------
Btgouiai
J«W-»S-«
•»
Itl 24.30!. ST &S1 C. » 1100 e, f» 1 n H? «t «21 C,  1« •• Bg »t HO
                                                                                      (COITIIIED)
TISSUE |
:rj.



EIW3UIB WUTE
Ingestion



RCIBOD
US



OF CISIS
10



JM6S
•at jives



•Ell
9s, • or - 21 ng/aaT



6Eimi IITOHIUlai
IOM after aaanpplcaaatad intake of
2(4 aq/l«T. Data, Croc VT 1-0*7
•ipcrlnaatal periods.
nnlwrsltj students and eaploTevs, a
nar*e ml a teachac. InlUparoua,
ng*a 19-29 jr.
Rio^MBlti calanee cllqhtlv negative,
nfleetliq intae^itte Intake (60t of
•JI).
itmssti: OBHE: HOI; CIICIDR:
»i6iesiin: siriuiS: PiospBOBOS;
DIIK; I1IIEE11 BITlFailSS: PBISrilCT
tznitvcx
- -
lsh«, J.B.
Scbotiald, y.l.
6ran, R.I.
Inerlcaa Journal of
Clinical Intritlon


 II
 Itl St.«3BO, If 12M C. BP 2095 C, TP  1 aa Hg at  1292 C.  14 a« Ig at 1510 C
US SHI

«1T2
lorta
















*113
BlooJ




«1T«
Elood















EIPOSBB! 10DTE 1
1

















'























HJHTICIL |
BffTBOD |
„

















IIS





us
















•niBSR 1
or cisss
2

















60





a) 18
bj 20
O 25
dl «J













I1ISE

0.38-B. 86 ag/9 <*et «t)

















3.85-15.1 «4/l





a) Vot given
bj lot given
c) Fat given
d) tat glvca












(•EXT
mi

0.62 * or - 0.3« og/g
fv«t «t)
















9.93 + or - 2.25 «q/l





a) 0.96 og/100 al
b) 0. «5 ag/100 ll
-) > 1 U9/100 al
1) > 1 og/100 al
neilaaa











PJGI)
GEIFB1L IITOIUTIOI

Biles

Icon a grovp of 61 a«topsie«r
farensle nedlcal eianlnatlcns. Japan.
I ales, naan age H0.6 re. f«a«l«s.
•can aaa 37.4 Tr.

UICT amiTS: trropsiES; JIPII;
iioima: ntsnic; ciDani: COEE.TI
CtlORIOI; CCEPTtS; I BOS; BIBCOCI;
IltTUB; IMilESIDR; tHBlIZSE;
losioinj: iniion; scuuias:
SflHin; TITHIOII: TiaJDinn; n»c:
GCtC; B»R»l; LITEI; tIBlIIS;
CHtBBHI: CZIEBEUDI: HZUT; ID5C1IS:
piicn»is: siirs«; LOSS; loni;
BITU.3; COIT1MTITE ET1101TIOTS ; S!I;
fCHISIC BSIICIM
lo eorrelatien bef »n concentration
and age, aex, or anktnq.

B»altiT» nonfasting 15-83 ji olds.
E100S; BEHSUJIBIII SIT BODS;
iiieinsi; amis
a) tors liiiaq < 1 kn (con saelter
tl Gltls Uyl.q < 1 ka fro* suiter
c] Groan children
4) taral children
Htlaatsd (ten qrapk.

School-age chlldcen llilnq >aar Pb
stelt«c In Belgian. Controls tro«
raral and artan aceas.

niGimst; ciDiion; IBSEHIC; HSEIIC
CE1IKIC COBICUSDS; CBILOBEI;
IlIISTtTlL linOSPSJSIS; SHIITEBS:
"ITALS; BlOCt: DBISS; SE1GI3B;
PCPOtlTIOB IIPOSOBE; BOBJl IBE1S;
CBEII HESS

imaEscE

Tnkava, S.
SHnkl-lanvnoto, B.
laaao, K.
Terai, R.
1980
Irchlves of
Environmental Realtb
35(1] :3S-m










Pleban, P.I.
Cearsoa, K. B.
19T9
Clinical ChenlstCT
>s 15-191*

Sachet, J.p.
Boels. 3.
La over ra, I.
Eraau. f.
ClaeTS-Ibdrean, f.
lafantalne, 1.
Terdnrn. S.
1990
Ecvlronaental Eeseacch
22195-106







-------
faaaa
7«39-9«-5
•I
Itl SV.9380.
             IF 12»» C.  BP 2095 C.  TP 1  aa  B«  at  12*2 C.  10 ••  B« at 1510 C
                                                                                    (COItmiO)
Tissn
*1TS
Blood.
sens
»17S
Brala
•177
Brill
• 17»
Iteatk
»17» '
•tic
siposwj sotn



BkalatloD

laitmciL
BCHOD
us
>*
us
mi
us
i
nun
or USES
20

3

31
22
III6S
0.9«-2.92 19/1
•| 0.11-1. a 09/9 (Mt rt)
b) 0.42-1.1 ag/j (net *t
C| 0.0«-0.91 aj/9 (nt
¥t)
d| lot gir««
-
a) lot fflru
b) lot »iTe»
c) tot girt*
d) lot givei
•> lot 9ir«a
f) lot 9l«n
at given
lot giro
lot glTei
BEII i GEIEEU iiroBBMioi
i
1.82 * or - 0.6» 07/1 i 1C correlatloa betveea coDccctratlon
1 nt t$€, MX, or nokiB«.
1 Bcalthr. •oafutiog 15-83 jl o!4>.
| StCOB SEI1M; HMSTOlnlWT IRBO9S;
I tncmsi; RETUS
i
•I 0. S» » or - 0.27 | •) fil«, ccnbni, 9 a«bj«cts
*lutloiia, Japan.
ng/g (nt «t) I Bilas, •*•> 19* »o.« yr. r«ul«m,
j Maa aq« 37. a jr.
1 met ntims: IOTOPSIES; juu;
I HORinH: misnic: cinnirsi COBILT:
1 cfFOBitm: corrsB: isoi: HIKOIT:
I iioKrv; iieirsiVR: micirtsE;
1 «eBiniu5: iniBoir; scMoitn:
I stiEiiae: iitHim: miDiua.- n»c:
1 COLD: Bioiiii: LITEBJ KID»ITS:
1 CIBEBSfR: CEIE8E1£09: HBlSt; BOSCIES;
t EHCItlS; SPUEI: LOKS; 10BTI;
I imiS; CO»P»B1TIT1 ETtLOlTIOfS: SET;
I fClEfSIC 1HICI1E
I
1
a) 2S.S * or - 0.9 1 a) Slabni patlidas. 11 saapl«s,
aaoVg 1 cceffieloit af varlatioB (CT) 11. 9T
b) 2». a » or - 3.3 I r) Can late aocleas, 13 saaples, Ct
aaoV9 1 •'M*
e) 3«.a 4 or - 1.6 t c) PmtaMi, 12 saaples, CT 1«.5t
uol/g 1 1) Sibctaitla aiqra, 6 saipl«s, CT
a> 22.« « or - 2.0 1 21.71
aiol/9 1 «! Cerebral cortex. 15 saaples, CT
e) 15.8 • or - 1.8 t ««,5*
»oV9 1 d Rlppoeaipai, 9 aaaples. CT 35. OT
f> 32.8 » or - 3.8 1
aiol/9 1 Utopsj mples
»ry «t 1
SB 1 CIBEIBU. COEIEX: niSVIEBEn BKTHO5S;
I ciicnn: eoprzi; noi; iiisimsi:
1 EHIl: IBTOPSIK
3.0 a9 1 C 1 saapled at cat* of 1 I/a In. 2-10
1 ala after baraio? * are veldlag rots.
1 OltrecsltT pkfsics "bop. Florid*
1 F1CEI91; acnTS: 91I1TI: CIICIW;
1 CHtosMS: cnomi: copm: IBOI;
1 I»D: »«u»SE; ncxEi: POTISSWB;
l Sutra: Tninvi: TIIIDIBB; znc; IIB
1 FUinioi: rsBis: IIDISTIIU
1 IT90SPBSBK: TlaCE EISBIITS
1
) 0.83 ppa 1 a) learal*9 dl»afcl«d
1 0.58 ppa 1 b) Coitcel*
1
1 Ktraini) disable* a*d aorial 3rd aad
1 «tk 9cade atadeats 1* Canada.
1
1 cucin*; Baensim; portssioBs
1 scnun: oomi: coia»; copcEi;
1 TtOI; Itat: RtKinSSl MIC;
1 cttoMQ*: Limvn BncniT; BCTILS;
l mil ntimi; CH»D»
RFCEEICE
Pletai. P.I.
pearsoi. K.B.
1»7»
Cllaleal Chealstrr
25(11J s«»5-1918
Tnkata, B.
Saxakl-Tanaoto, K.
laa«o, E.
Terai. a.
1980
trcairee of
EavlronMatal Health
35 (tt : 3«-««
Goldberg. «.J.
illea, I.
1991
ClUleal Cbealstrr
27(a):S«2-56«
"
ftksals»0n. K.E.
)esaedeleer. G.G.
Johansson, I.B.
BlK!hest«r, J. ».
197«
lanals of Ocenpatlonal
Rfgleae 19:225-23*
Plbl, B.o.
Parkas, B.
1»T!
Scleace
198(«313) :20*-206
                                                                                                                                                                                       VO
                                                                                                                                                                                       00
                                                                                   inn
-------
1«39-9«-S
II
It! 5*.*3*0. BP 12** C, BP 2095 c. IP 1 aa
                                              at  1292  C.  10 •• 84 at 1510 c
                                                                                       (COITXmiD]
nssci
41*0
Bair
»181
Itir
*1«
lair
iKsnn Borex



iiunxcit
BKHOD

U
U
IOHBBB
OF CUBS

al 38
b) 2*
O 37
1) 2*
•1 16
a w
*) 23
b) 19
o «2 a>
1*
•} 26
O *0
11KB

•) lot 4iT«a
b) lot gin*
c) lot qirtB
4) lot 4ima
•) lot giTe»
f) lot giTeo
a) 0.030-2.663 «4/g
b) 0.156-3.72* «g/4
C) 0.030-3.72* 14/4
a) 0.123-*.901 vg/g
•) 0.038- 1«. 330 B4/9
f) 0.018-16.330 og/q
mi | GEIBBIL IimiHIOI
1
1
| le*l««. 2* represcatatlf*
1 Fce-aaalyflta treatveata ara
I tabilatei. Tk* f«sibililr of a
I aollatic, m«-«aak poltcT foe h«.lr
I iiilT«i« la mtllMfl aai «ipport«d.
1 cirtn; -ttKt VLtmtn-. ins;
| ITSTJU.Il: BIlSmiBlR BCTBOnS;
I anus; pBOTins; COIPIUTITZ
1 ninitio»s: UBnm: MTIMII:
I itsnic; Bi«wi; Bionre: CIOTIOB;
| C11C1VBJ CnOtllZ; CB1OBIBB! COB11T;
1 ccmi: siiLTUB; g/4 | c) 111 eoitccl*
1) 0.279 og/4 | 1) Blla loltipla Kl«eo*i« patients
•) 0. *6< ng/q | •] r«Ml« »ltlpl« Klcroslc patlaata
() 0.403 14/4 t f) 111 Mltlfl* Klacoti* patlaita
italiaas | Sa«pl«« froa 7 scalp sites in «ack
1 cabjKt.
I cum: iDoiTS: CBITHI nitons
I STSIEB nsiisBt mi; tionni:
1 ««cmi-. ciicniB: cnoilii; cop>n:
I envt IOPIIB: m«s»itsi; anus;
I snnm; suns; SODIBII; SHFTH;
| 1111B11V, T11C
i
BRBZfCX
Ckittlcbocoagh, G.
1980
Scl«aca of the Total
EvTiroamBt «:53-T5
eibcoB. E.s.
Omolta. B.S.
19BO
Ivtritloa Baports
IntAnatlocal
21 (3) : 3*1-3*9
Bjan, D.I,
Rolzbacher, J.
Stnart, o.c.
1978
Cllalcal Cheatstrr
2* (1H -.1996-2000
(HIT MCI)
                                                                                                                                                                                              \D
-------
Raigaoese
7*.21-*«-5
Be
»tf 5*.*3«0, SP 12«« C. BP 2095 C. TP  1 » Hg at  1292 C,  ID  » Hg it 1510 C
                                                                                      (C01TUOED)
TISSVE

*1»3
Heart


















• 1«
KUaer

















• 185
KUaeT






















EXFOSORZ eon
































































am men
BRBOD
U



















I*


















•1























roam
OF CaSSS
a) *
b) 2


















M ^
b| 2

















1 8
1 »
c| 10





















SJ1CB

a) 0. 26-0.11 ng/g (vet
*t)
b) 0.52-1.4 og/g (vet «t

















•) 0.21-1.0 og/g [»«t vt)
b) 0.43-0.63 «g/g (vet
•t)
















) 0.050-0.85 eg/g
) 0.0050-3.62 »g/g
> 0.013-1. 7» ag/ij
fet rt




















111) | GEKRU IIFOSR1TIOK
j
1
t) 0.33 » or - 0.06 | at Sales
aq/g (vet vt) 4 t} Feaales
b) 0.96 » or - 0.62 |
ag/g (vet vt). | Fro* i group of 41 autopsies.
1 forensic vedlcal examinations, Japan
1 ealts, MID age »0.6 rr. Feiales,
1 a«aB ag« 37.4 TI.
1
1 T»cr BtBBBBIS; 1UTOPSII5; jiPltr;
I I1DBIIB9; »»S!«IC; CIBSIDB; COBU.T:
I C BROS 111 t CCPP1B: 1801; IEKUBT;
| I1DIHH; (IlGICtSIOS; MIGtffESE:
| SIBIDIHJ; UTIBOII; SCHDIOfl;
| SILIlin; TIIUIOK; TIHDIOB; ZI«C:
| COLD; BBOBIHE; III ft: KIDIZTS;
| CIEIESHJ; C18EBEILOB; HEIST; BDSCLES;
1 farcins; SPIEBB: LOBCS; lOBTi:
| *IT11S: CORPtBlTITS STUItaTIOISj SIX;
I TCBIISIC REtKHE
1
a) 0.76 * or - 0.28 | a) Bales
«9/ males
b) 0.73 « or - 0.1* (
«4/9 («et vt) | Itoi a qroop of 61 autopsies.
| foc«*slc eedieal axa»lnatlo»i, Japan.
j Bales, Bean age «0.« Tt. Females,
I Han aqe 37.4 fr.
1
1 1B1CI tXIRins: aOTOPStiS; JaP»;
I iiOBinm; aEsnic: ciDsioa: COEUT:
i ce«o«iatf; catttti teats itttcasr:
I IIDIH1; gaSIISIOl: ItlGlHZSI;
I toinn*: IITIBOII; SCIIDITIB;
I SILIIinS; TIT1IIOI; TalUItfg; 3IBCJ
1 GCID; RIORIII; IHEB; !tID»BIS:
1 CIBIBSnif; CZ1EBEUOI; B31II; RDSCLES:
1 PlfCIElS; SPIEZ1: LTJPGS; IOBTI;
I RtTaLS; CORPallTITE ETUKaTIClS; SET;
| ICKISIC HZDICIIE
a} 0.073 19/9 1 <) Coitrola
b) 0.073 a?/g 1 I) vorkec group I
O 0. 076 ug/g | c) Vorkec gcoap II
«et vt 1
elians I Ceceasei ret luerr a«d shelter
1 tetkets, aget S5-7S rr. exposed to
1 tearr tetals 1-3 tecaies. Ilae
1 tctiem retlraaeit aM death 0-1.5 rr
1 It group I aai 2-19 ji, group II.
1 Coatrols, ages «3-72 re, vbo lited SO
1 ka (ros tie factory. Svedei.
1
1 SHIM: CafiaTBRS; KIMITS; 11*31:
1 tEiGs: coRpitHira EnLoiiiois:
1 IIIIISTCIat ITGIEIEi 1JISOEIHBIT
I BIT BODS; iniBOIT: atSElIC: CISRIOB;
1 CfSni; CBICBtVR; COB1LT; COPPJB:
1 cent: isoi; iuwtMin: isic;
1 eiiSMiss: ancoiT; HOITBDEIOR:
1 IECSPBOSOS; BTOIDHJ1: SCHDIOT:
I £itEnn: snr-s; TI»: TOIGSTEI;
1 ZIIC; 9!11TB HIEIEDS: IIDDSTBIll
t PtinS; SREimS; TEllVSXOH
1
EER1BDCI

Tukan, 15.
Snuki-Iasoaoto, B.
Aaano^ K.
Terai, R.
mo
Irchires of
EnvicoBaeatal Health
35(1):36-«»












Takava, R.
Samkl-Iasuioto, R.
Itano, K.
Terai, B.
I960
Irchires of
EnTironaeDtal Health
35(1); 36-**











iraae, 0.
Vordbecg, 6.
vester. P.O.
1980
Science of the Total
EBTltOBient 16:13-35


















ilKT Past)
                                                                                                                                                                                          N5
                                                                                                                                                                                          O
                                                                                                                                                                                          O
-------
BiagaMM
7«9-«-5
Si
Itl 5«.«3M,
1«« C, Bi 2095 C, W 1 » If at 1292 C, 10 u Ig at 1510 C
                                                                                     (COITIIOEM
1ISS01

•us
Kidney











• UT
lifer

















»188
Li tec




















• «»
liiar










EIPOSUIE BOTH

novation




















































IngestiOB











IBUTTXCU
IHBOD












n


















11

































IDBBEB
a; cists












at 11
b) 3

















a) «
b) 9
O 10































BMSE













a) lot given
b) 0.96-2.3 uq/9 («et >t>

















a) 0.017-2.18 19/9
b) 0.07S-2.9". 13/4
c) 0.06t-2. 26 ag/4
«et vt






























SEil | GEimi IlrOBMTIOS
1
1 feTle*. Profile «f lealttT subjects.
1 Baseline data for determining ehuaes
I in Batritiaml st«t« fro. industcial
1 fcod processing techniques.
1
I in ZSILIIE; UUIT5; PSTDE; nrurtS;
1 EIOOP SEBHH; HUB; KIDRTS; UTIt;
I HLIti ISTIH: DIITS; FOODS; SOUS;
| TIGR1TIOI; CUHIOT: COVPIB;
I BKGjiisi: inns: TB»CE zinnTS;
I ZIIC
i
1
>.) 1.T * or - t.& ( »1 Bal«s
uq/g l»et »t| 1 l\ Mi«l*i
b) 1.5 » or - D.B8 4
ng/9 (»et »t) 1 Tcoi a eaa *qe «0.6 jr. paiales.
1 Man aqe 37.1 Tt.
1
1 mci niBins; itrropsiis: JIPII;
I iltJilian; usmc; ciDUtn; coant:
1 CBBCBIUS; coEPtE: 1BOI; aiBcuai:
I iiciuB; sicitsioB: IU&IIISE;
I BdEIlini; (ITIIOBT: 3CHDIUB;
I sninttg; TiiMioa: miDitu: z»c;
I GCIE: BlOmt; Lit IB; KIDI1TS;
1 CIBMIUB; CtEIBEllH; II1BT; 10SCLIS;
t IHCIItS; SPLEII; LOKS; JOBIi:
| IR11S; COIfiBlTin ETUTHIIOIS; SH;
| TOinSIC BIEICIII
1
a) 0.11 ag/g I <| COfttcall
b) O.'O I9/-9 | t) lorter  group It.
1 Controls. >?eB «3-72 yr, vko lived 50
1 k« fton tbe tactocj. sveieii.
I stnn; ciciTHB: tiiwiis: HUB:
t lines; comuTin ETHBITIOIS:
I IIinSTBIll HTGIBI!; B!lSD8Htn
1 tmaos; trnsoBT; USHIC; ciositja;
1 CISIOR; cmtoeiai; COBILT; COPPIB;
l ecu; IBOICJ urrmoB; LIID;
1 BI1GHISI; 11BCDBT; BOlTBDnOT;
I iBospaons; BOBions; sci»Bim:
1 siitnan: SIITEB; TI»; roiosru:
1 tne; siuig BiziSTJs: itDosnui
I EE1RS; SBIIIBBS; II1HJBIH1I
1 t«fte«. Tcotile at h«<b7 mtiject*.
1 Eascline data foe deteraiaing changes
I In iatcitio»l stites froa liliatcial
1 fcod processing techniques.
1
I in lEiuii: uaits; rnrus; nrans;
I eiOOO SBHOB; BilE; KIDIITS: tHIB;
1 Bill; IITIEI; JIITS: FOODS: SOUS;
1 uenuioi: ciDBim; COPPE1;
1 mansE: inns: TBUE Eiznris;
1 UK
1
BEIEBBICI

Gatkrle, B.E.
Boblnaoa, B.r.
1»7»
•e* Zealand Bedical
Journal i7 (603): 3-8








Takara. 1.
Sazuki-taxanoto. 9.
Inno, X.
Teral, H.
mo
Iccbiies of
InTlconnental Be*ltt
35(1|:JS-44











Bcnne. B.
•ardbeci, S.
fester, P.O.
1480
Science of the Total
EnTiEoment 16; 13-35
















Gntfarie. B.E.
Eobinson. B.r.
1»7I
lev Zealand gedical
Journal S1(S03):J-8







(HIT SISB)
-------
m S«.»3»a, IP 12M C, BP 209$ C. It 1 n tg at  1292 C,  10  M B« at 1S10 C
                                                                                      (OORIIOBD)
tissis
• 190
l»9
• Ifl
l»«q
«m
lilk
Bxpostn ion


IIIITTICIL
BRM0
U
It
latest loa
•ram
w cuts
•) 2
14 2
•1 •
tt 9
c| 10

I1KI
•) 0.39-0.68 «j/j (net
•t)
D) 9.09-0. 76 «j/g (««t
•t)
a) O.Ott-O.tl ««w
b) 0.0015-0.60 19/9
c) 0.00 70- a, 31 *g/g
let «t

•MI i etitui IIPOBUTXOI t nnsnici
t 1
i i
i i
«) 0.5* * or - 0.21 1 «l Ida 1 Tifcam, I.
ooyg (net »t) | t) r«nles I Snaki-Tasuoto, 1.
b) 0.«3 * or - 0.47 | | IUBO, I.
•9/9 (««t «t) | »co« * ?ro»p of f 1 »tep>le«, t T«r«l, s.
1 famatc w41nl «»laatlou, Japan. 1 1*80
I lalM. Han tg» »0. t re. F«Ml of
I •«•> •«• 37.* TC. | CavicouHtal E««ltb
1 1 35(1|:3*-M
I T»CC ntiziis; unotstsst ami; i
1 ttvnnf; Msnic; CIDSIUS: COMLT; i
1 cnoitivi; coFRi: in»; aiicsiT; I
i mm: IISIBUIJ uvenisi; i
I imoiDi; union; scmm; i
1 siinmi; tniiiaB; uuoioR: me: I
I eotot stosni: IITBU tmiiis: i
I ciimmi: c»niu.«ii inn: BOSO.ES: i
I limits; spiEBi; lotss: totrti i
t StTHS; COWlUnR (TUB1IZOS; SFI; I
1 ictnsic IUICIIB i
i i
I i
a) 0.054 wg 1 •) CMtcol* 1 Brail*, D.
b) 0,029 ag/g 1 t) lort«c elt«r 1 Scl«*e« of the Total
I >crt«r«, a4«* 55-76 rr, azpoMd to I JiTltoMant 16:13-35
1 l«ar? Mtals 1-3 tect&as. Ill* I
1 t U-72 ye, »bo lived SO I
1 ki ftoa the factory. S»ad«n. |
1 1
t SIEBSI: cttims; riBtiTs; iirn; i
| IOI6S; COIHMTIVI XTltUTIOIS; I
I IltlSTIIlL BTSIBIS: RtSniEBZIT 1
1 IfTBODS; IITIBOIIJ USKIC; C1DHVI; 1
I cisni: cnonvi; COBUT: COPFSI; i
I GciD; itoi: iiirnna: iitB; i
I Misirasz; incoiT; (rairBotxff: i
I ttostamas} iraroiTS: sciiBimr.- i
i snmrat SIITCT.- i»; mesni; i
( IIIC: IMlTf HIIIPS: KDOSTBItl I
I pitits: siftms; Tsiiouoa i
i i
1 »•«!•*. Profile of aealth? najeetc. r ectkrle, B.B.
1 I»«liie data for feteniale? cbU4«> I tobiuoa, n.T.
\ la ntcltloal «tit« fcoi iadwtrlal | 1978
1 food ftoct**i*a tockrlqves. I Wen Sealaad Sedlcal
I 1 Joanal »7 (603): 3-8
1 in XBUiit: IBIITS: rrrus; nrtns; i
I BIOCD sini; nit: noins: LITBI: I
I mi: mm: Dim: FOODS: SOILS : t
| •HR1TIOI; C10IMB: CO»PEB; 1
1 tiietnsi: mils: ntci HtERzns; i
1 TIK 1
« 1
lint us 8)
                                                                                                                                                                                         NJ
                                                                                                                                                                                         O
-------
7»39-9«-5
II
It! 5«.93*0, flt 12*1 C, B* 2095 C. W 1 •• Bg at 1292 C. 10  M  Bg at  1510 C
                                                                                      (CORI(IED)
IISSBI

4191
BMCl*

















«19«
VaKceaa

















Spiaal
cerl












XPOSVBE BOBtl




















































IIU.TTICIL
ntaoo
11










I
1






n


















X-^rar cpectcoe












BBBBEI
or USES
•I •
bt e

















a) 5
» 2

















•1 1
W 1
cj 1












IMBt

a) Bot glTia
b) lot glrei

















a) lot glvea
•b) 2.0-2.1 eg/g (Mt «t)

















a] lot applicable
b) But applicable
cj lot applicable











(IIX1
	 BMB 	

a) 0.28 * or - 0.21
•g/g (Mt «t)
b> 0.33 * or - 0.29
ig/g (net ttj















a) O.«1 « or - 0.37
•g/g (Mt «t)
b) 2. 1 » or - 0.07
•g/g (»t rt)















a) 72.3 eg/g
b) 132.2 ag/g
c» 1*.3 eg/g
Drr «t










VIC1I
SBI1B11 IBfOIfliTIOI

a) Bale*
r) femlei

ftat a groip at »1 titopilec.
foreaele Mlical exaalaatloae, Japan.
Bales, aeaa age «0.t 71. Ttaalo.
aeaa age 37.* rr.

iitci niBtits; imontxs: mai:
iivnioi; amtic: CIOBIOB: CDBU.T;
cnOBMB: CCfMI; I«01; BBICOIt;
IIDXOI; BtfillSlOB; BIIGIBBSI;
lOflDIOB: llHBOITi SC1IDIVB;
snimi; TRiiioB; nuDXOBj cttc;
soiB; Biotiit: inn: HDIHS;
cnmni: cnnnxn: m«t: RDSCIBS;
siicius: semi; towssj ioni;
anus: COIPUITXTB ETIIOITIOBS; sn:
fCCIBSXC BStKIlI
a) lales
t) reaale*

Froi a groap of C1 aetepcle*.
f emslc aeJical eualnatlou. Japao.
Balei. eeaa age M. C rr. Feaales,
•eai age 37.* ft.
•
Hici niBins; amoFmsi Jim;
nanin: MSBBXC: CIDBIHII COBU.T:
CHCBXDI; CQina; KOI; BBBCqst;
IICID1; BieitSIOB: UIUIESI;
BQVIDXBii: aiTXBOBT; SCllDXOt;
sntinai TiuBioa; nnoxoi; zxic;
CCIB; BtOBIlt: IXTBt: IXDIBTSi
ciitBBin: czimuai; IXUT; tasciss:
I1ICIBU; StllBli IOB5S; IO1H:
IITILS; COBPUlflTB ITllVinOIS: SIX]
retnnc aniciiB
•1 aetoc Mitm alataie patleat
t) Botor Miroa dlmeee patleat
c) Control
Teatral bera tlane, aMopai
lo ietectable Ba la 5 otter patleat*
aad 11 eoatrel*
fatleats aied of arotrophlc lateral
•eleroil*. a) age 59 rr aaa b) <9 rr.
Ccttcol, age M TC, U«A ftea Ing
catclBoaa.
THIS; IDUITS; tOTOtSISS;
I'dtOHISCfltlB OISnSBS; SflML CO1D;
tiokccnaBiHioi; citcma: COPPBC
IIGI; LI1D; BlISallSBi BRI1S;
sitnnas UK

IBRUICI

Telcava, B.
Snaki-Ta*aaoto, B.
laaao, 1.
Tetal. H.
1980
krcalTe* ol
CaTlroa«atal Health
35(1) :]«-«•











T«k.a«a. B.
Svzakl-Taaaaoto, B.
laaao. X.
Teral. B.
1980
ircalTe* of
Enrlronaental Health
35 (1) : 3«-««











Eirluder, 1. 1.
Mttea, B.a.
1979
lends of learologr











                                                                                                                                                                                            NJ
                                                                                                                                                                                            O
                                                                                                                                                                                            Ul
-------
  langaaesa
  7«3»-«-5
  IB
  Itf !». 93BO, IP 12** c, 8P 2095 C,  TP 1  aa Hg at 1292 C. 10 u Bg at IS 10 C
                                                                                         (CORIIUSD)
IISSIX



»19«
StlMB



















«197
arin«
















EIPOSOSS BOOTI










































IIUTTICIL
IRIOD


H




















US

















man
OF casss


») 5
b| 3



















at 17
b| 15
o 16
d) 7
e) 21
I) 23












a»6E



a) lot given
b) lot given



















a) lot gi»«l
b) Rot jlv««
c) lot given
d) »ot given
a) lot gives
J) lot given












sua i esituL irannnoi
1
1
1
«) 0.1« * oc - 0.26 1 a| 1tl«s
•9/9 (oat «t) | C) resales
b) 11 » or - 9.2 ug/g I
(••t wt] 1 *Toi • groap of 61 autopsies.
j forensic sedical exaBinatioa*. Japan.
I Balm, man age »0-6 jr. Pesales.
1 Mai age 37. 1 vr.
1
| T11CI BIEBEITS; (ITOPSIBS; J1P1I;
1 «ic«irj«: nsETic; CIDHIOB; COBJIT:
1 cBnoann: COPPBB: IBO»: HEICOBT;
| IIDIVB; lUItSKTB: RU61IISE;
1 mBiDwa: iniioR: sc*roioR:
1 SILEHUB: TllUItn; T1UDIOI: ZITC;
I GCLD: BIOBIK; tlTEt; KIDIEYS:
I cisiBis): citEBCiLirg: HHBT: snsctss;
1 EiicBiis: sciBEi; Lines : loni:
I IRalS; COBPIB4TITJ ETUDITIOIS: SKI;
1 fOBMSIC BEEICIIE
1
1
a) 0.95 og/9 I a| Boys lltiof < 1 ki froa aaeltet
creattniBe t fe) Sirls liviog < 1 In froa saelter
b) 0.60 ag/g | c) Orbaa boys
craattaioa 1 9) Vrtai qirls
c) 0.80 ng/
-------
Bcrcurr
7O»-»7-6
Bq
lt» 200.59. IP -38.87 C. BP 356.72 c. »P  2115(8-3)  aa Bg at 25 C, 100 an 89 at 260 C
                                                                                       (CQItllVSD)
TISSUE

«»*
Biooa
















• 200
Blood






• 201
Blood












4203
Blood,
seres








BIPOSIM tone

Injectloa
















lagestion







lagestioa
Inhalation












lagestioa










lltLYTICll
BETB09
US
















US







•1























BOBEIE
OF CASES
6
















339







a) «
B) 3
O «











1










B1BSB

a) lot applicable
b) lot applicable
c) 3.6-19.3 ng/nl















10-167 ng/g







a) 1.6-17.3 ng/g
b) 3.7-8.5 ng/g
c) 0.6-a.a ag/g
Freak «t










*) lot applicable
b] lot applicable









U1B

a) 17.7 ng/nl
b) 8.0 ag/al
c) lot gifen














-
tot given







a) 5.9 ag/g
b) 5.3 ag/g
c) 2.9 ng/»
Fresh vt










a) 115 ng/100 al
b) 10 eg/100 nl









6IIEB11 mOMUTlOB

a) liter 0.6 al/kq of gaaaaglobalin,
1 patleat as in a|
I) • iik after gaacoglobolii aed
C-penicillaniM (2 gn/day) . 1 patient
c) 5 patieats

2C yr old receiving gannaglobnlia.
containing 0.01t •erthiolate (50.3 ng
Bc/al). leceiveft «o-50 ng Bg/yr.
ether patients receiving 0.6 nl/kg
«»«y 2-3 rt, no Bg sensltlvitr.
Pink, sealing, preritic palas and
•olea. flashed cheeks, photophobia.
irritability, treaor, altered
sensation it fingertips, slomd nerve
coadactlon velocity.
BIICBIY; BHUS: SLOOO; TOIW; BUll
PCISOIH5: BISSISTS; BSDO TBESlPT
Ktlaated ficn graph.

Ontario Indian «ho at* coataninated
fish.

I1CCD; BIIB: BIBCOST; HETtlS; CMtDl;
TOPIUTtOI BIPOSVSB; FISBBS; DIZTS

a) CceapatlonallT exposed
fc) In etposed area
c) Snrgical ratieats

Tegoslariaas, ages 1*-63 ji.
latapsies of at and b) .

IIDflSTBIll POLL0TIOI; OCCOHTIOBU
iinsDS: POPVUIIOI nvosmi;
S01GEHT: BBiCUBI; RBBCOIT OBSW1C
coaponos: TOSOSUTII; imopsiis;
HOOD; Blim; KIDBBTS; UTIB; 10ISS;
1D5CL1S! SP1ZBI; THYROID GlliBS

a) It adaissioa
b) 1 no after dinereaprol therapy
Dose, «30 ng nercuric chloride

5 ji old Beiicaa-incxlcan.
ictonlul tain, malting, bloodj
stool.
Icite reaal failure
HOOD SEBDB; HIBCOET; HTTHS;
CBIIDXII; BIT11 POISOIIBG; CIS!
EIS10IIBS
(BBJI P1BZ1 ~ ~ 	
KFIBIiCI

Batheson, S.S.
Clarkson. T.».
eelfaat, E.8.
1*80
Joaraal of Pediatrics
97(1)s1S3-1S5












Phelps, S.I.
Clarksoa, T.H.
Kershav, I.G.
Wheatley. B.
1980
Irchives of
Environmental Health
35 (3): 161-168 .
Itosta, L.
Zelcako. T.
Bavnik, T.
levstek, B.
Dernelj. B.
Byrne, I.B.
im
Coaparative stadies of
Tool anl Invironneatal
Coataalnation.
Proceedings of a
Synpoaion held in
Otanienl. Finland.
lagnst 27-31. W73
Seiael, J.
1980
Pediatrics
6«(1t: 132-13*








                                                                                                                                                                                              NJ
                                                                                                                                                                                              O
-------
7«9-«7-«
B*
111 209.SI. tf -38.*? c. »  3S«.72 C, T» 2110(c-3) aa Hg »t 25 C, 100 « Bg «t 260 C
                                                                                       (CORIBinSD)
1XSSSE
«203
mi>
»zw
Bill*
«2«
Brail
«20C
iraia
Bifosm ton

Xagestioa
laaalatioa
lageatiOa
akalatiea
lUimclI
•ROOD
•1
U
sc

IDBB1S
or CUES

•) s
bj «
9

IHCB
a) < or - 7.* ug/g (»»t
«t|
b) < or - 3.1 119/4 (wet
"t>
C) < or - 9.3 «g/g (*«t
«)
d) 1.1-3.0 119/9 (wt «t
a) 181-I3C7 ag/g
b) 15-«1 ag/g,
Fresh »t
1
'
._
SO. 1-2*7. 1 ag/g frest .t
lot applicable
BE** | GEtiiiL iiFotauioii I Birstncz
I I
I i
a) 1.9 * or - 2.C 1 •) Rales, ceiebraa, * subjects 1 Yvkava, B.
•9/4 (»et vt( 1 *J resales, cerebraa, * sabjects 1 Sazaki-Tastaoto, B.
b) 1.2 * or - 1.5 1=1 Bales, c«rebellaa, C subject! I laaao, R.
ug/g (»«t wt) I ') f«a»l»«, cvrctxllna. • aab]*eta 1 T«r»l, B.
c) 3.3 » or - 3.3 1 1 1980
'9/9 !••* >t) I Txoa a gro>r of f1 antopalva, I lrehi«*s of
4) 2.2 » or - 0.9 i toravlc a»dlcal •xanlaatioa*> 'apaa. 1 5BTlron««atal Eaalth
ag/9 (>«t *t) I Ralca, Mai •«• iO.C rr. P«aal«8, I 3S(1|:36-M
| MH a«« 37.* Tt- 1
I HIM niciins; inoniKi j»ni; i
I imnroBj itscnc; CIDSIDB: COBUX; i
i cnoiioK; COPPTI; IMC HICOII; i
1 linn: ainssim; msinsEj i
I coixravi; iBixton; sciiDin; i
| H1EIIBS; TITlTIali TlIlDIdl: IIBC; I
1 eciOi Btoiini: IITXI; nvins: i
I C»ZB(irt: CI1RBUOR; HURT; HDSCIES; I
1 i items ; spini: ittss; writs i
I RR113: COBPU1TITE tT»L01TIC»S; SEX; 1
I FOlItS 1C BIDICIM 1
I 1
a) 1654 ng/g I a) occapatioaall; flfos»S \ Koata. 1.
b) S3 ag/g 1 t>) la «iposti) arc* 1 Sclmko, T.
rrash »t | 1 Earaifc, T.
I l«topsi«s, TngoaltwiMis, ages 19-75 f t«TSt*k. ».
I jr. 1 D«ra«l], E.
1 1 Brne, I.B.
1 IlDDSTlIlI PCL1DIIO1: OCCOP«rtO»ll | 197*
1 BIZMDS; POPOUTIOS nPOSOBZ; I coiparatln stadias of
1 snaiBT; HIBcnii HSICDir CISIIIC 1 Food «»d Ia*lroaaeatal
1 CCBPOOIDS: TOSOSUTIl: inTOPSIKS: 1 contaaination.
1 B10OD: Btlll; KIOIETS; L1I1B; LOISS; t Proceedings of a
| ROSCLES; SPltn: TBTSOID Sums I SyipoBina beld la
I 1 otaaieai, rinlanil,
I 1 »»0.5 ppa total Bg I Saitfc. J.c.
1 1 1»81
j Caaallaa ladiaas, aertanest Oatarlo 1 Joaraal at Inalytiesl
I | Tozloolog; 5:90-9S
I TISilS; toot COITHIUTIOR: I
1 ncusTtni rcLiimoi: POPOIHIOI i
1 [tposnti: itnii UEIS; BSBJI uus; I
I >nn poitmo*: aEBCDBT; BESCOBT i
I c«si«tc coapcnios: Httn: Mmsis; i
f IITEB: menu; SPLEEI; CIIIDI; i
| IROPStVS |
i i
1 i
.9 ag/g | MtopiTr 7 ac oil girl exposed to 1 Beatlako, H.I.
I vapor. >A. 1 Toapklns. l.L.
I I Soclaad. T.*.
I Peter, Toaltlag, pallor aafl dyspaei, I Baasoa, B.B.
| Colloved sevca days later by apoea. I Jactsos. a.B.
I tllateral paeaeotlorax, seTere I 1981
I acidosisff coaaf selzarer aad .death. j Aaericaa Joaraal of
I | Diseases of Ctildrea
I Parti*! ateltctasls vitk s.alliig. | l3S(t):«2-M
1 fecal atynleal hrperplasia, »ad I
1 l«qmantici of cells of alfeoli, j
1 alveolar daets, aad bronchioles. f
1 Byaliae acatcaaai, aad Latra-*lveolti j
1 aeaorraages observed. Oeg««rative 1
I chaages la illB«T«. diMase fatty 1
1 ctaeges ia liver. I
1 1
I HISSlCinSlTIJl 40TOTSIIS; CUE 1
I Bisioms; iipins: RSTII toisonte; i
1 tiiii; icitius: tun: LOBES: i
t incoit: must iiinmo* i
t i
(HIT »»6I)
                                                                                                                                                                                              NJ
                                                                                                                                                                                              o
                                                                                                                                                                                              ON
-------
Mtcirr
7*3»-97-«

•1
It* 200.59, V -38.87 C, B» 354.72 C,  »» 2110(1-3) u Bj at 25 C. 100 •• l« «t 2CO C
                                                                                   (CORIIBZD)
1ISSBI

»2«7
lair










«joe
lair

















•209
lair













1210
Bait















inosmi VOTOB































IikalaUoa
P*rwl





























kiumcu.
anioD
us





























»













us
















10BBX3
or cisss
B| 31
b] 22




























2













2,32*
















•1ICI

*) «0t glTII
b) lot 4iT«*




























•) lot 9l*«
b) lot gi»«a
c) lot girti
S) lot gi*«











*} 0.2*-2J.a* ppi
b) lot giiaa
e) lot gi»aa
1] lot glTan
•) lot 9! TIB
f) lot giiaa
g) lot gif«B











nai i cmm nrotuTxoi
i
a) 1» ppi | •) l**i*l*g dlsatl«d
b) IS ppa I k| COBtral*
1

1 *tb arad* 0t*d*its is c*&ada.
1
I ciicivi: i»6Rsioi; POTissiOB;
I SCBHB-. C It BIM-. COBU.T; COMBS:
I IMI; MID; nieinsB; mcj
i cnogin; insioi! IBICVIT; anus;
1 Bill: CSItltlll: ClllDl
i

1 t*fc«lat*t. Ib* f*astbllltT of a
1 belittle, io-«sk policf for hair
1 aialTiU It oitllMd a*4 s*pport*jt.
I nnti; met ntnttsi uii;
I IVSTlUIl: BJaSTIlMIIT HCTBODS:
I iniis; ptornis: cwMtinn
I ITllVkTIOIS; atOallOB; aiTIMIT;
I usiiict itinit nonii: citina-.
1 ciiciui: ciieuii: craonoB: COEIII;
I ccjMt; c ill MB: enunni: eou>;
1 UBiiit IMI: tiRBkvn: nit;
I iintsni: MNinsi; BBSCVH;
I miionoii iicrn; PBOSPHOIBS:
1 fctissni: SOTiura: SEIIIIDI:
I miooi; sitmt SODIHB: siionm:
i snroi; TII: iii»iio«: TOKSIBI;
| ZIIC; HKC11BB
i
a) 181 ppa 1 a) Cas* 1 - k*ad kale
b) 11.9 ppi 1 c) Cas* 2 - »«d kalr
c) 16.8 ppi 1 c| Cas* 1 - pabic kalr
d) 9.*» ppi |d) Cas* 2 - r«ble kalr
1 (cat l*T*ls
1
1 Bntlsts, •» and SO yr old.
1
1 Tlio«T ttaaor, final OstviloratlOB,
t imr BMiorr, IrcltabllitT, k«daek*a.
I Baicl* palaa. anonila, nlgkt loss.
1 lieoordliatloi at llibs, Daam,
1 tipkorU.
1
I scoiuio; Kin nisoinej BUI;
l inis; siBcniii mils: OCCDIITIOHI
1 IUIIDS; SBOKItG; DIFIISTtl
1
a) 2.19 ppi | •) l*sld*Bts of Sklkoki, ial« and
b) 1.48 ppi | Ciaal*, all a»w, 1>75-1 »7«
c) H3 ppi | b) 7-9 rr old ial*s
4) t.W ppi | c) 7-9 Tr old fnaln
e) 1.*2 ppi I d) 1*-1S TT old ial*B •) 1»-15 Tr old
f) 2.83 ppi | fcialaa
q) 1.60 ppa | f) 20-10 rc eld *al«a q) 20-a« jr old
GeoMtrlc mau I t«aal*s
1 t)-g) nsldcrts of Tokisfclia
1 rr*f*etaca, 1977
1 lgrle*lt«r*l area of Tokickia*. Japan
1 >b*r* Bg eoBtailiatloa Is l*m than
I «1amk*t*> OB the Ixlaad.
1
1 Jmt; attoltscEITl: » DOLTS: |«I;
I cntnn: six; Biit: ro»oi.inoi
1 IIPOSDH; BlICTIT
1
•nnnci

riki, i.e.
tart*!, g.
1977
Seine*








— — — — _____ _
Chittl«boroagli, s.
1989
Sdme* of tk* total
lailtoaaalt la: 53-75















Sriiagton, I.S.
Cross, J.D.
Dala, I.B.
Lcnikan, J.B.I.
1980
Jeorial of the Sociatj
of Occupational
Badleli* 30:37-39








SUioima, S.
Kinca, a.
•akagana, B.
Tatao, g.
1980
tBVirona«ital B«s*uck
22:22-30











{lilt »»«) 	 — -
                                                                                                                                                                                      hO
                                                                                                                                                                                      o
-------
Bercnry
1««-9T-6
Bq
lt» 200.59,
              1 -38.87 C, BP 356.72 C,  TP  2110(E-3)  m Hg at 25 C, 100 BB Bg at 260 C
TISSUE
• 211
Bair
•212
Hair
• 213
Mart
»21«
Bcut
iiposun son


1
l

aninicii
BET BOD
US

n
l
1

» nsiis
or cisss
339

a) 10
W «
f
B1IGE
2-52 ug/«

a) < or « 1.1 ng/g (net
t)
) < or • O.B1 ug/j (ret
«t)
lot applicable
Bill | CBIE11L rtTOlBAflOI 1 8EFEHEBCZ
1 1
1 1
1 1
lot gi»«n | f«ir adjaceat to scalp. Estimated I Phelps. B.v.
I frea graph | Clarkson, T.».
1 | Kersaav, T.O.
| Ontario iBdiaas »ho ate coBtaBlaated j »h«atl«y, B.
I fi*h. I 1980
j I archives of
| HOOD: Bill; BEBCOBI; IET1LS; CM1D1; 1 EBTironBental Health
1 EOPDIITIOB iiposms: risBis; DIETS i 35<3i :i»i-i«s
1 1
1 1
I 1 r«»l«» of mrld llteratare OB the 1 Jankiaa, 0.*.
I acewlatloa *nd blooanceatratloo of 1 1*79
| nlectail toilc trace aetals in h»av 1 EPl-60D/«-79-tHt9, la*
j hair aaft nails aid other unallaa I pp.
1 talr, far, aalls, elaws and boat*. I
j latalatea by geographic area, j
I objects, s age »0. 6 rr. Toalea, 1 Itehires of
I IHD ao« 37.4 fr. I FnTironeenttl Bealth
1 | 35(1) :36-M
1 TSICI SLisins: itrropsm; JIPII: I
1 HiBidiii: (PSEirrc: CIDBIOB: cosiic; 1
t CIBCSIO1; CCPPII; IBOf; BEtCDBT: |
1 IICITH; aieiisioB; BMeiizse; i
1 I OB ID lU 9: 1IHBOBT: SCIIOIOB; |
I ;n.snvi: Tiiifios: TIHDIHB: xnc: r
I eciD; BBOHIII: IITEI; noins: i
1 CIBIB101; CIBEBBltn0.5 ppe total Bg 1 Salth, J.C.
1 1 1981
1 Caaaiian ladlaa, northwest Ontario j Jonraal of laalytical
I 1 Toxloologr 5:90-9«
1 iisais: FOOD ooiriBiiinoi: i
I iiggsmii pouotioi: POPOIITIOJ i
1 IIPOSVI;: tnui «sis; DBBII 1B1»S; i
1 ntn poitniof; HSsaKT: BIBCDTI i
| CfCHIC CCSFC01B3: BE1IT; III1ZTS; I
I tifti: rticim: spini; cinoi: i
I ItTOPSIES |
(lltT PaGI)
                                                                                                                                                                                           ho
                                                                                                                                                                                           o
                                                                                                                                                                                           00
-------
lereory
7««-*7-«
It! 200.59. St -38.87 C. M 35C.72 C. n  2X10(1-3)  u tq at 25 C, 109 •• Hg at 2«0 C
1XSSH

1215
Kidney
















•21C
Kidney





















•217
Kidney











(218
Kidney










IPOS USE sans










































Ingestion
Inhalation











Ingestion











lliLTtlCil.
BETHOD
U

















11






















U











GC











IUBSIB
or CISES
a) 20
b) 3
















a) 8
b) 9
o »




















a) 5
b) 6
c) 2










1











IMGI

a) < or - £.6 «g/g («et
•t)
b) 0.98-3.6 ng/g (vet «t)















a) 0.05*-0.027 ng/g
b) 0.017-0.50 ng/g
cl 0.0*1-0.47 ng/g
let tit



















a) 5,500-21,000 ng/g
b) 79-8.000 ng/g
c> 30.1-364 ng/g
fresh »t









lot applicable











Bill

a) 2.0 » or - 2. a
ag/g (net «t)
b) 2.* » or - 1.3
eg/g (««t irt)














a) 0.091 ag/g
b) 0.10 »g/g
O 0.0*6 ag/g
Vet »t
Redlans


















a) 12,224 ng/g
b) 1,227 ng/g
c) 197. »5 ng/g
Fresh irt









1223. t ng/g fresh «t











emiii nrotBmoi

a) Bales
t) resales

Iron a groip of «1 intopsies.
forensic sedical examinations. Japan.
Rales, Man age «O.S yr. resales.
neaa age 37.4 yr.

1IICE ELEflMIS; ITOOPSIIS; MPtl;
itoaiina: iismc; CUBIUB; COBUT;
CMOBWB! CCPPIB; isoi; BIBCOBT;
•»iiria: iniBort: SCHOIOR;
SIIEII1S-, TITHini; TISIDH3B; ZI1C;
«OtD; BSOBI1I; LITIB: KIDI1TS;
C1BEBBBSJ CltEBBLlOB; BElBt; BOSCIBS;
EllCmtaS; S5IIM; IOIGS: lOITa;
BJTIIS; COR11S1TITZ HiLDlTIOHS; SIX;
ICIEISIC BEBICIIZ
a) Control*
1) lorker groop I
c) lorker grogp II

Kceased refinery and snwlter
letters, ages 55-76 yr, exposed to
keaiy totals 1-3 decades, tine
tttveen retirement and death 0-1.5 yr
it group I anil 2-19 yr, groop II.
Controls, ages *3-72 yr. »bo lived SO
III fron the factory. Sweden.
sut ii: cioitras; EIDIETS; imi;
HUBS; COBPJEITITE ETliniTIOKS;
IVCQSTRIll BIGI2BE: HEaSOBBBEHT
HITEQDS; MTIBOtt; USSBIC; CaOSMB;
CISPJB; CIBOBIItl; COBUT; COPPEB:
eOlD; IIOI; URBalDR: LEaD;
(llOlKESf; BIBCOIT; ROITBDENH:
FBOSPHOSOS; BDBIDIOR; SCIIDIOH:
fllElIO!); SIITEB; Til; TOIGSIEI;
zi«c: Bttna laiuis: noosmii
FURS; SBEITE8S; TELLOaiDB
..
a) Occnpationally exposed
c) la exposed area
c) Controls

Tgqoslatians, ages 1«-7S yr.
Intopsies.
IIDW3TR11I POLIOTIOI; OCCtJPITIOJII.
Hl^lltDS; POPQ11TXOR EIPOSORS;
SUBGEHT; BtXCDBI: "IEBCUBT OKOiHIC
CCiPOOBDS; TdGOSLIITII; iBTOPSIBS;
HOOD; B«»II; !tID»BIS; 1ITE5; IOHGS;
BDSCLES: SPL1EH; TBI8OID G1IIDS

Intopsy, regular consnner of fish
containing >0.5 ppn total flg

Canadian Indian, northvest Ontario

FISHES; FOOD COffitlBIUTIOi:
naosTBiu FciioTioi: POPOIJTIOJ
II?OSOBY: BOBII IREIS; IBBJH IHJIS;
nits potiinio*: BESOT ai; aEscnn
Cf5»lIC COBTCmiDS; BE1BT; XIDRETS;
tlTEB; P11CIR1; SPLI'S; CH1D1;
1ITOPSIES
itnincs

Inkaia, B.
SaTtki-lannoto, B.
Isano, K.
Teral, B.
1980
Archives of
Environmental Health
35(H:36-«»










Brane, D.
•ordberq, G.
•ester, P.O.
1980
Science of the Total
InrironMat 16:13-35

















Kosta. 1.
Zelenko, T.
BaTnik, T.
levstek, B.

Byrne, l.B.
Coaparative Stadies. of
Food and Earlron.ental
Contanination.
Proceeiings of a
Syaposina held in
Otanieai, Finland,
ingvst 27-31, 1973
Cappon, C.J.
5.1th, J.c.
1981
Journal of Analytical
Toxicology 5:90-98







(Hit PJSI) 	
                                                                                                                                                                                             K)
                                                                                                                                                                                             O
-------
ttreaty
1M 200.59, B* -3«.«7 C, B* 356.72 C,  va  2HO(E-3)  aa Bg at 25 C, 10O aa 89 at 2«0 C
                                                                                       CCOItllOBD)
II9SBI

«1»
(idaer


















«220
liver


















(221
Ilrer






















lirOSVM BOOT!

laaaUttoa































































aiunicu
BCTBOD




















U















1
I
1

U























1TJHBM
OF CaSBS
1



















•1 5
M 7












1
1
i
1


a» 8
b) 9
ct *





















niai

lot applicable



















•) < or - 1.7 »9/9 (Mt
vt)
b) < or - 6.0 vg/g (net
•t)














- - i
t
») O.Oie-o.l* no/?
b) 0.016-0.10 «9/a
c) 0.01S-0.13 09/9
let at




















nil | GBIZIll IirolBlTIOB
1
12.2 09/9 | latopsy, 7 ao old girl exposed to
I vapor, 91.
I
1 Tever, vosltlag, pallor and dyspnea
1 fellowd Mvaa dare later by apiea.
1 cilateral eaeasothorax. severe
1 ecidocis, coaa, aellare, aad death.
1
1 fartlal atalectaais «lta svelllag.
1 fecal atypical ayaerplasia. aad
| deagueatiOD of cell* of alveoli.
| alveolar deets. aid bnwchiolei*
| Byallae seatraaes. aad imtra-alvcola
f ctaaoas la tldaey*, Jiffase fatty
1 caaage* la liver.
1
I gissiCBtsms; IUTOMIES; CISB
| tlSTOKBS; ItTlaTS; Wilt WlSOinC;
t iia»t KiBiirs: IITBII loves;
| BJtCOlI; BHllS: IBBEL1TIOB
a) 0.60 » or - 0.70 1 «» Bales
39/9 (vet vt) ( t) Tevales
b) 2.3 * or - 2. • )
ao/o. (vet «t| | froa a groan of 61 aotopaiea.
| foreasic cedlcal eiaalnatioas, Japaa
t Bale*, aaaa ae* «». 6 yr. Veaales,
t aeaa age 37.* yr.
| TB1CI nSBBBTS; UKOPSIBS; JUII:
1 tiraim: ustncs ctosion: COBUT;
I cnoiiai; copRB; isoi; aBBcnxy;
j UOIUB; BlGBESIBBi IIIGIIBSB:
1 usiDins; airiHOaT: sctanma;
1 siLmos: TiTinw: THUDIOS: tire;
1 eoiB; BJOBIII: urn; n»»iys;
I CMinvii; CIIBBZUVB: BBaBT; BOSCLZS;
| 'IICBI1S; SP1BZI; IOKS; lOBTai
| IRalS; COBFIBITITI BTUDlTIOaS; SKI;
| VOIIfSIC BFCICIM
1
|
a) 0.037 nj/9 | a) Coatrola
b) 0.03* 09/9 | b) Worker groap I
ct 0.037 eg/g I c) Vorter groap II
«et vt i
Sediaas | tteeased refiaery aad acelter
j vorkers, age* 55-76 yr, exposed to
I beavy aetala 1-3 decades. liae
I r«te*ea retireaeat and deatb 0-1.5 yr
1 Ja aroap I aad 2-19 yr, group II.
I ceatrola. ao.es 13-72 yr, »»o lived 50
1 ka froa the factory. Svedea.
1
1 sum: cturas; cirans; urn;
| 1D65; CORfaBtTlTZ ITIU17IOIS;
1 IltOSTtlll BTfilZIS; BSlSOnBZBT
I BTTBODS: miBon: usnic: caDRioa:
t cuwi; cnoanrii COBIIT; COFPEB;
| fiOID; IBOV; UtTBJIOS; IBaD;
1 •iieiiisi: incoBT; BOLTBDMOTI:
I iBospBoias; BIBIDIOH sciigitm;
I sitinra; sum: tii; Toissni;
1 me: IIIITB uiuos: novsTBiu
i titns; sniTns: -numis
i
IBFIBEBCE 	 1

Boatlabo, B.C.
Toapkias, a. I.
lovlaad, T.I.
Baasoa, B.B.
Jacksoe, 1.8.
1981
itericaa Joantal of
Diseases of Ckildrea
135ft] :<2-4«











y«xa>a, a.
Saiaki-Taanaoto, B.
aaaao. K.
Teral, i.
t»80
archives of
Bavironaeatal Bealtb
35fl|:3*-«a












raae, D.
ordberg, S.
ester, P.O.
ego
cieace of tie Total
aviroasent 1C 213-35


















                                                                                   (MIT t»SI)
-------
earcarr
7«3»-»7-«

Itl 200.5*..
              ' -3*. 17 C.  tt  356.72 C, TP 2110(1-3) SB  89 at 25 c, 100 aa Bg at 260 C
                                                                                        (COBTZinEB)
nasai

122]
liver










«223
liver








4224
liver


















•225
laa«

















EXKStBE BOntX

lagestioa
XabalatloB




















lakalatlo*.






































niimcii.
«WO»
n










ec





























„


















B08BEB
or cuss
a) 5
b) «
c| 3









t









1



















«) 3
b) 2

















I1KE

a] as.711 Bg/g
b) «1-1«» avg
!) Is.s— 48.B ag/g
fresh «t








Bot applicable









lot applicable



















a) 0.28-2.0 ni)/g (vet «t)
b) < or > 0.06 ag/g (wet
•t)
















BE1B

a) 250 ag/g
b) 99 ag/g
e) 34.5 ag/g
Presh vt








14 5. 7 ng/g fresh wt









5.1 ag/g



















*) 0.17 + or - 0.9B
ag/g (vet *t)
b) O.OJ * or - 0.04
ag/g tvet vt)















GSIIBU IimilTIOl

a) occapatlcaally exposed
i) IB expose! area
c) Costrols

latopslet. Taqoslaviaas. ages 1S-7S
7t.
IIOOSTtlll PCUirtXOB; OCCVMSIOIU
BataBDS; POPVLaTXOB EXfOSOvBj
snenr; ancmi; mem* oismc
CCBJOBI&S: TuaosiiTH: movsiES;
HOOD: BttiBt KiDnis; iifii; Lmes;
BQSCLBS; SPIEBI: TBTBOIO QlaVOS

litopsT. regalar ooasaaec of fish
eeatalatag >0.5 ppe total Bg
Caaadlaa ladlaa, aorthvest Ontario

iisns; n>oi coRuxuTioi;
IBDDnSIll JOL1DTIOI; POP011TIOB
IIPOSUH; tttBaL MlaSJ DBBIB UMS;
IKCT ponutioi: TBscosi; aiscoii
ciGinc coiMviDS: HWBT; KIDIIISI
lITIt; FLlCtni; SPIESI; CIIID1S
latopsf, 7 ac old glcl eipoaed to
vapor, la.

Kver, voaltlaq. pallor a ad dyspaea.
followed sevea dar« later bv apaea.
t {lateral pienaotboraz. severe
aeidosis, cosa. celxare, aid death.

Partial ateleetasls vita mil lag.
focal atypical kipatplasla. aad
desgnaaatlca of cells of alveoli.
alveolar dncta, aad ferotchioles.
Bfalia* Beatzaaes. aad latra-alveolar
aeaorrhages observed. Degeaeratlve
ciaages la kUaeTa, Uffnae fatty
ckaages ta liver.
MSSacmstns; inorsxES: cisz
BISTOSIE3; TirilTS; BSTtl POISOBIIS;
tllll; KXEltIS: 1ITEB: 1DB6S:
HlCmiT: BPI115; nBallTIOB
*) Bales
I) Tvsales

Iraa a groap of 61 aatopsles.
forensic aedlcal exaaiaatloaa. Japan.
Bales, aeaa age aO.« yr. reaales.
aeaa age 37.* rr.

TVICE I1EHIIS; iBTOPSIIS; J1P4I;
iioBiiiji; t«smc; CWSHJK; COBUT;
CBSCB1U1; COfPElj IMI: HBBCOBI:
ncran: iiisiEsniB: IMGUESE;
lIBIEItl; iniBOHI: aCMDIOB;
SltMUPI; TIIMigg; VIIIDIOB; ZX*C;
COLD; BIOBUI; inn: KISBBTS;
ciitaim; ciBEB'iitifl: IEIIT; nnsais;
IIICBMS: SPLXEI; lOKS; aOBTt;
VI1I1S: conaakTITE EfUDitloas; SEI:
fCIIBSIC RIDICXK
(IIXI PIG!)
IETEBBBCE

Kosta, 1.
Celeako, v.
Bavalk, T.
Levstsk. 1.
Seraelj. 1.
Byrne, I.I.
Cosparatlve S tidies of
Pood aad ZDVlronaeatal
Coataalaatloa.
proceed ings of a
Syaposiua held la
otanlssl, TlslaB.4.
avgist 27-31. 1973
Cappon. C.J.
Salta, J.C.
Joanal of laalvtical
Toxicology 5:50-98






•oatlako. B.E.
fOBpklas, l.L.
8o«lt«d, t.».
Baasoa. B.B.
Jacfcsoa. ».H.

laerlcaa Joaraal of
Diseases of Cbildrea
135(1) «a2-«*











Tokava, B.
Sazakl-Iasaaoto, B.
liaao, I.
Taral. B.
1*80
arealves of
Zavlroaseatal Eealtb
35(1)! 36-44












-------
tttevij
•s
itl 200.59. IP -38.87 C. BP 356.72 C,  vp  2110(1-3)  u Bg at 25 C, 100 •• Bg at 260 C
                                                                                       (C01TH1EO)
IISSOS
4226
lug
«227
Ian?
• 228
I«g
t
EXPOStJIE BOOT!

lagestioa
Inhalatioa
lakalatioa
I iiaiTTicii
IBTBOB

n

10HBKS
or cisss
a) 8
b) 9
C) •
«) 3
bj 5
1
1
1

B11GB
a) 0,0010-0.17 mg/g
b) 0.018-1.13 og/g
C) 0.012-0.097 »g/g
let lit
a) 127-1510 ng/g
1) 12-271 19/9
Trash vt
lot applicable
iiti | GIIZUL nroEaiTioi i miBBici
I 1
i i
I I
a| 0.00*0 «g/g I a) Coatrols | Prase, D.
b) 0.031 og/g I b) vorker groap I I loraberg. G.
cl 0..038 ng/g | c) Worker groap II | tester, P.O.
let *t I I 1980
SediaBB t tseaasea refiaery a ad saelter I Scieaee of tbe Total
| loiters. «q«» 55-76 TT. «rpo««a to I ZniroiMnt 16:13-35
| I««TT Mtals 1-3 decades. Time I
| tctveea Tetlreseat ad death 0-1.5 re 1
j it gtoip I aid 2-19 jt, gconp II. 1
I cmtrols, aaes 43-72 jc, vho llwd 50 I
1 ki froi the (aetoCT. Snedea. 1
I sncEi: cioitnsi XIOIETS; LITXI; i
1 IHIGS: coHPiiiTire BTILOITIOIS: i
I IIDDSTII1L BIGIEIK; niSOEIBZIT 1
| BIIBODS! IIIIHOIT; »5»IC: C1DB30B; |
1 CISDB: CMOBIDI; COBU.T; COPPBI; t
1 SOLE: IKOI: unuiiB: HID; i
1 iiismsE: BZtcnBi; HOIIBDBIOH: i
1 ftOSPHOIUS; TOBIDIHB: SC11DIDH; |
| 51LEIHTH: SIITJB; Til; TOI6STEI; I
I uic: BIHTI Hizuas; IIDHSTBIH i
| EI1RS; SBS1I1RS; TEUORIDR 1
1 1
1 1
a) 77t nfl/g 1 a) OccipatioMllr eipased 1 Kosta, 1.
b) 131 n 7 1C old girl exposed to 1 RootiBbo, H.E.
I 
                                                                                                                                                                                          N3
-------
Bercarr
It! 290.54,  IP -3I.IT C.  » 3SC.72 C, It 2110(1-3} an «g at 25 C. 100 an Bg *t 260 c
USSBB

1229
laacte

















4230












1231
tail















ET.KOTH HOOT!




















Xaotstlon
Inhalation












Ingest ion
Inhalation
Oeraal














1IUTTXCU.
BZTBOD
n


















n












Bl















IOTSIS
OF ClSIS
a) 6
1 »

















a> 3












2















E1WI

] < or • ».« »g/g (»«t
t|
b) lone aetoctftd'
















a) (.5-106 ng/g
b( 1. 9-2* H4/9
Fresh vt











a) lot giT«»
b) lot given
c) lot given
4,1 Hot ?U«t













BB1*1 | GHESIL IIFOBBUIOI
1
a) 0.77 * or - 1.8 1 •) tales
eg/9 (vat vt) | t) Fe aal«s
b) Kane detected |
j Iroa a groea of *1 autopsies.
| forensic aedical oxaniaatioas, Japan.
\ Bales* aeaa ao^a 40*6 vc» F«»a,V*s,
1 aeaa age 37.4 vr.
| TtlCl ILIB1B1S; JOTOPSIISJ JIP1I;
1 itunnm: tesEiic: CIDHIOB; COBILT:
| CESOBlai; COIFEB; ItOI; HSBCUBT;
| IIUIBB; IISBtSKIl: MIGUISC:
1 euBiDirn; iiiiutPir: SCIJDIDI;
I SIT. MTU": TIttBItrg; tilaOIUB; ZIIC:
I 6CID: BBOBI1I; 1IVIS; KIDHTSi
I CIBIBSTS; CIEEBEiina; BSUI; HHSCLSS;
1 PiicEiis; sritia; loBss; toni;
1 amis; COHfHtTITE l*llD«IOaS! SIIj
1 ICBItSIC BEDICIITE
1
a) «3.5 ng/g ( a) DecapaticnallT «iposefl
b| 1«.0 ag/g I t) In «zpos«a area
Fresh vt I
t latopsies, tagoslavia, ages K-75 yr.
|
t IKVSniU POIIBTtOI; OCCnTtnOML
1 BII1SDS; POPOtiTIOl HPOSHSS;
l smsEii; nrtcusT; IUCQBT assuic
1 COBPOIigS; USOSLITH; tUTCPSIES;
1 HOOD; B1IIB; KIDfEIS; IITEB; LOIGS;
1 stsciES; spirei; TIYBOID eims
l
1
l
l
a) «9S ppa | i) Case 1, fingernail
bl 313 ppa | t) Case 2, flag«rMll
c) 17.1 ppa 1 c) Case 1. teenail
4> «.S 5?» ( S> Cue 2, tcevall
1 leak levels
1
1 Dentists. *• nd so vr oil.
1
1 linger treaor, vlnal deterioration.
1 [oor aeaory, irritability, headaches.
1 nisele pains, aaocezia, veight loss.
1 lacoordlaaticn of llabs, nausea.
1 euphoria.
1
1 sconiiD; aiTii FOISCIIKG; BUS;
l unsi aiBCDEi; IIETIIS: ocetPiTiosiL
1 BiiuDS: stems; DMTISTI-T
AEFEBZICE

Tokau, B.
snnki-Tasvnoto, 9.
laano, K.
Terai, a.
1980
accVives oC
Zavlronneatal Eealth












Kosta, L.
Zeleako, T.

lerstek, B.
Darnel j, g.
Byrne, I.E.
197*
Coapacatlve s^vdlos of
Food aid Eavironneatal
Contaninatlon.
Proceedings of a
STapoaiae held in
Otanleai. Finland.
Kigast 27-31, 1973
Svnington. I.s.
Cross, J.D.
Dale. I.a.
lenihai. J.I.I.
H80
Journal of the Society
of Occupational
H«Ucine 30:37-3*









-------
BcrewY
Itt 200.54, tt -M.tT C. tt 3SC.12 C, » Jit 0(1- 3) aa Ig «t 25 C. 100 » 19 at 2«0 c
                                                                                     (COBTIBPED)
TISSVB
«232
tail
«233
•»il
•23*
Patcreas
sxtosviB ton



•IU.TTICU
nraoo

u
u
•rani
or cuss

a> 9
b) It
7
3
tlKC

•1 Mt aiT«»
b) lot «!T««
a) < or • C.«5 «9/j (Mt
«t)
b> < or - 0.81 09/9 (»et
•t)
BEM i GiBitit XBroiBiTicir i scnazBcs
i I
i i
I 1 r**tmt of meld llt«c«ttr« o* the 1 Jmklai, 1.1.
I accaialatloa aid biocoKftatratloa of I 1979
1 *«l*ct*4 toilc tr«c« a«t»la in bnaaa 1 lM-«00/»-7*-0»9. 18*
j kilt »4 mils »i oth*r aaaaallaa 1 pp.
1 aalr, (»c. Mil*, clan* aaft boots. I
1 I»fc»l«t»d by 7*«9Tltbf 20-60 TC alia I Uastlfaon, P.S.
1 | »«l»oo. 9.1.
l itnits: szi; mis; BITIEB ; iionmB; i Boor*, c.c.
l mnaiTi HSBixc: S»SWB; cmatOT: I 1979
1 citcim; ctsnw: CBIOHOB; ccaiu; i sd«»c« of the Total
1 CCPPEB: «»(invc SCUD; IBO«: HID; 1 Zarlroaiut 13:131-1*0
I S1GIESIU1: BIKAIESB: RSBCOBTi 1
I (ciTBDinB; nctn: rotission; i
| lOBItm: SIIBIIIH; SIIICOB; SILTSBi 1
i sorrow: STtcirrtrs: TIC Tinrrua; i
I tJUDIOB; MIC; IIBCO1IDB 1
1 1
1 1
a) 0. N * or - O.IT I <| »«Ie» ! Tak9», B.
•j/j (»«t «t) | 1) F«»*l*s 1 S»t»lcl-T««m»oto, g.
b) 0.27 » or - 0.«7 I 1 laaaa, K.
19/9 f**t *t) 1 ttoi * ?ro«p of SI avtapci**, 1 T*r*i, B.
1 farcaslc i«41c*l azaitntioie, Jip»». I 1980
1 Bales, Mas »9« IO.C yr. P«a»l«s. 1 Irchlies of
1 i«*» *9« 37.* TT. 1 EaTtcoaavatal 8*altb
1 1 35{1):3<-«
l Tiict nsiizns: tmorsits: JUIB: i
t iiBBina; iBsnic; cioatna: COBU.T; i
l ciioiUBB: ccmB: IBOB; BEBcrai: i
1 113t08t BIGBCSXIK: B1B61VESB; 1
i inttma: iniaon: SCIBHVB; i
l siisnos: tiUBioa: nitDiua; IIBC; l
1 COID: moBiii: insi: nvtzts: I
I ctiiBtoa; cnniuoB; mm-, suscies: i
1 flBCIMS; SFtSSBi LVKSi 1OIT1: 1
l 
-------
7«39-97-«
•«
It* 209.59,
               -38. 97 C, BP 356.72 C, TP  2110 [1-3)  u flg It 25 C, 100 M Hg «t 260 C
TISJBB

»23S
PitaitatT












• 2J«
Placenta







W3T
Stleea

















Spleen











•239
Spleen









SIPOSIJU tOIRE
























	 .


















Ingestlaa
IBkalatlOa






















ifiimcii
BTSBOH














9C








n


















»











sc










EOT in
OF CISIS
*
s
3-




















at 9
b| *

















•1 3
M 2











1










U*6I

19,000-C«.Oa4 a«/g
163-23,900 ng/g
6.V-63.6 »g/g
nab «t










2.0-20.7 ng/g fresh «t








at < or » 2,1 »g/g (met

>) < or • 1.S eg/g t*et
•t}















a} 23-188 Dg/g
b) 11.8-20 ag/g
Fxe*h Vt










' lot applicable










IE* i i esiEtu. urosiiTioB
1
•.6,000 ng/g 1
$.225.* mg/g 1
SBC'S •4/9 i Iv^oslwimSf &STt:
l Biiiis; cogpiMTifE ETiiaincvs: sir;
1 KBEISIC BtCICIBE
1
a) 79 ag/g 1 al Occvpetlaiallf -exposefl
b) IS. 9 ag/g i fe) In expoitd araa
Fresh vt |
1 latoislaa, TBgoilarla, ages H-7S TC.
1 I1DOSTTU11 PCLtVTICB: OCCOElIIOIll.
I BtllBOS; MPBHIIOI ZIFOSOBS:
1 SOtCZBT: BJSCCST; BBSCOET OBCUK
I CC1WTI1DS: IBSOSLITII; IJTCPSieS;
I noon: mil: Kisratss mis: LOTOS;
I HSCLESl SfLEEI: THTBOID GIHDS
1
1
t
1
80.* ag/g freu vt I latopiT, regalar oo*s»er of flak
I cc»t»lal»q »O.S fpm total Eg
1 Caaadtaa ladtaa, »ortk«est Oitarlo
1
I ftSBES; FOOD COMlHIBlttOI;
\ IIOQSTItlftI, fQtd>mTOl* BQ¥1Ht>TIOV.
l IIPOSDRE: «OBII nits; TOSH isiisj
1 flTEB POttBTIOI: HEBCUSI: HMCtlDI
l cismc canpomros: BBIBT; KIDIEIS:
1 II1R; PtlcBBIi; sPlEEr; CUUDI:
i
lEnmcz

KOBta, I.
Zeleato, T.
BtTBiX, T.
leiatek, B.
Deraelj, B.
BTEB«, I. S.
1»7<
CoapacatlTe studies of
rood aad EiTlronaeatal
coataalaatloa.
Proceedings of a
Syapotiu held la
Ctaaleal, riolaml.
aagvst 27-31, 1973
Cappoa, c.j.
Salth, a. C.
1901
Joacnal of Inalrtlcal
ToxlcologT S:*O-38



...
Tukava, S.
Saickl-Iasaaoto, a.
laaao, K.
Teral, B.
1980
acclilTes of
EaTlroamntal Health
39 (1) • 3i— %l











Zeleako, T.
Bavaik, T.
levatek, B.
BrcaJj''!.^
1974
Coapar attire studies of
food aad Eaviroaaeatal
coataalnatlon.
Procaedlaga of a
Srapasioaj held in
ctaaleal. Finland,
iarjiut 27-31, 1973
Cappoa, C.J.
Smith, J.c.
Joacnal of Analytical
Taxlcologr 5:90-98







-------
tticw
7M9-97-4
Bg
Its 200.5$. I? -38.87 C, BP 3S6.72 C. It 2I10(B-3) u Bg at 25 C. 100 •• Eg at 260 C
                                                                                     (COIII*BED)
iissat
»2»0
Thyroid
gland
• 211
Dtiae
«2»2
Orine
«2*3
Ori«*
iirososi BOUT
Inhalation
Ingest ion
Ingest ion
ejection

1 t 1H1TTICJU.
BETBOD
u

us
us
BHRBEB
OF CIStS
a) 5
b| 6
0 3
d| 6
1
6
6
<
1IIGI
a) 21,300- HI, 000 ng/g
b) 69-26,500 agyg
C) 2.5- 15 ng/j
4) 7.1-507 ng/g
msn vt
•} lot applicable
n> lot applicable
-
) lot applicable
) lot applicable
) 23-66 ng/sl
5. 80-25. OD ag/2» hr
<1. 0-2.3* «g/2« br
Bin i GEBIM.I nroiauioB i sntsstcs
1 i
i i
l l
a) 51,222 ng/g I a) Occnpatiosally exposed I Xosta, 1.
b) »8»2.5 ng/g 1 t) In etposel area I Zelento, T.
c) 10.2 ng/g I c) controls I Ravnilc, T.
d) 11* ng/g ) d) sorfieal patients, one of *ban | terstek, B.
rresl «t 1 Dotted »Jth Eg and kai kigbest tissue I Decnelj. 1.
I l«nl. | Byrne, i.1.
1 1 t»7»
( I agoslariaas, ages H-75 yr» | Conpacative studies of
1 1 Contamination.
( IIB5STSIII POUBHC1; OCCIMTIOUI, I Proceedings of a
| BJZ1SDS; POFOUTIOI E1POSD8I; | Synpoalnn held in
1 soieiBT; BiEcoBT: siECtrar OEGHIC i otanieni. riniand,
| COSEOB»OS; roOOSIlTIl; 1BTOPSIJS: | Jognst 27-31, 1973
I EIOOD; BB»I»: KIIRTS; LJTSB: LOTOS; |
| 80SC1ES; SPHEI; THTBOID CtalDS 1
1 1
a) 90* ag/1 I a] It adeission 1 SeUel, J.
b) 1330 ag/1 I B| Hospital d»T 2 1 1980
| rose, 9S9 sg sercncie chloride 1 Pediatrics
| I 66(1)! 132-1 3«
] «.S TT old Bciicai-tMrican. I
1 1
I Tesiting, abdoiinal pain, diarrhea. 1
1 1
| Cloodr stools, protein aria I
1 1
| CIIIE; 1XBCOBT: BCTltS; CBILCSI1; |
| Hill POISOIIIS: CISE HISTOBHS |
1 1
1 1
a) 63 ng/il 1 *l Ifter 0.6 il/kg ga»aglobulii, f I Rethesoa. D.s.
b) 138 ng/nl I patient as In a) I clarkson. T.s.
c) lot given | t) Ifter 2 on/day I>-penicilla»ine, 1 | eelfand, E.I.
| patient, peak at 5 dars I 1980
| c) S patient* I Jon nil of Pediatrics
| a) end b) estiuted free grain 1 97(1) 1 153-155
1 29 TT old reoeiTing gaunglotalin, I
I contaiilnff 0.01V nertbiolnte (50.3 eg I
1 Ig/nl| . leceired »a-so sg Sg/rr. 1
I ether patients receiTiig 0.« il/tg 1
I <*err 2-3 ek. DO Sg sensitivity. 1
1 lint, scaling, pnritic palu and 1
1 soles, flnstcd cheeks, piotophotta, I
1 Irritability, treeoi. nltered I
I sensation in fingertips, sieved nerve I
j confection Telocity. |
l BticDiT: BRits: BLOOD: miE: ssin \
( EOISOIlfG: DISE1SES; DEUS 1BB1PT I
1 1
1 1
13.65 >g/2« hr I a) taw»aki disease patient* 1 orlovski, J.p.
lot given 1 t) Controls I fiercer, B.D.
| ) 1980
I 5- 11 yr oldi, vitb. (avasak.1 disea.se, 1 Pediatrics
I and controls. I 6«(«| :«33-636
1 1
I Terer, con1«Bctl*ttln, pharyngitis, 1
1 trTtnenn, trescal enntnen, cerrlcal 1
| idenopitky. 1
1 1
1 iiKgiT: inns; ntu. poisoius; i
| CHID1CT: OBHI; OISEISE3; CIS I I
| fISTOBISS t
1 1
                                                                                   inn
-------
Cercarr
7»39-«7-S

»t¥ 200.59, BP -38.87 C, BP 356.72 C, TP 2X10 (E-3)  am Hg at 25 C, 100 aa Hg at 260 C
                                                                                     (COiniHED)
HSSM
Urine
»2«5
Urine
Urine
IPOStJBE BODTE


Inhalation
aiunicu
mioo
us

us
•BIBE1
OF C1SSS
6
«) 70
b) «0

1 1101
a) 0-15 eoyl
tt 16-30 oj/I
c) 31-«5 «g/l
dj »6-60 ng/1
«1 > or * 61 a«./l
a) 0«OOV-0.«565 no/hr
b) 0.007-0.185 ng/hr
a) 0.007-0.614 vg/hr
b) 0.005-1.«01 ng/fcr
c) O.OOt-0.565 egAr
Bill | GEIEBH IlFOBBaTIOI
1
1
a) lot given I a] 3 patients
b) lot given I t) » patients
el lot gives | c) 7 patients
t) lot given I it 9 patients
e) lot given I •) 3 patients
| Bg dosage of «-73» ng (nean 1S7 >g1
( G). ovec 6 ao-17 vr (nean 6.5 vr) .
| *-C7 TT olds «ith
| 8IBCTBT; HFTILS: US III; DISEASES;
| CIKOTBIHP1
a) 0.076 » or - 0.012 I *) Controls
rea
b) 0.110 * or - 0.020 |
ag/hr 1 lonea. aesn age (2.3 Tr. fron
(S.E.) | Cd-eollated area (Liege), and
I controls, nean age 01.1 vr. fron
I Charlecoi, Beloiaa.
1
| BIOOD: BLOOD PLaSIt; Q1IIE: C4BBIOB;
I mo; asecust; tiic: BEIILS: BIIGIOB;
t is!-. popTamoi Exrosvis: IIDHSTBXU
| tCLLDIIOl: SBIITEBS; XIOIET KStlSSS
t
a) 0.065 ag/hr | a) Besilents of Liege (cost pollute*
b) 0.057 ag/hr 1 area)
c) 0. OM ag/hr I t) Besidents of Brassels (less
Seonetclc | icllvted axea)
1 c) tesideits of Charteroi (control
1 «•«)
I leans and ctmlative freqaemcr
1 distribaticns not neck different
I tetveen the three groups
1 Bsaltbr sablecta >60 ji old.
I iesl4eat> of the sane areas 25 vr,
I Hlgina
| EIIGTUB; ICBLTS; aSE; BLOOD PllSHi:
1 DBiit; c» cnioB: LE»D: BIBCOII:
1 IITM.S: me; IIDHSTBIU EBISSIOIS:
| tlDHSTBIll PCLLOTIOI; POPOUTIOB
1 IIPOSmtE; IBBtl 45BIS
SEFEBEICE
RaeaCT, H.B.
Carter, 5-F.
Teaian. ».B.
Thompson, B.a.
1979
British dedical Journal
lanervs, R.
Boels, B.
Bernard, i.
Bucket, J.P.
1980
International Archives
of Occepationa 1 and
Environmental Health
«5;271-27«
Boels, B.l.
Laaverys, I.E.
Backet. J-P
Bernard, ».
1981
Eavironnental Besearcli
2»s117-130
  Bercnrrtl*), Mtkrl-. ion (8 CI)
  •erc«rni»), »etnil- J9 CI)
  22967-92-6
  C-B3-Bg
  II 215.63
IIS5BB
•2*7
Blood


EltOSDBE EOHTE
Inhalation
-

111LIIICU.
BETHOD
U
oc


iraBza
OF USES
11. 17
controls


EIBGE
a) 67-518 ng/g
b) 100-15* tig/g
c) i.5-69.5 ng/g
d) 1.9-13.7 ng/j
BIT »t

(HIT
REal
a) 227 no/g
b) 129 ng/g
el 27.0 ng/j
d( 5.7 na/j
Dry »t

P1GB)
Gllntl IIFOBI1TIOI
a) Total Mrc«cy, dantista
t) Total aercvrr, non-exposed
ccntrols
c) dethrlnrcnrv, dentists
6) BetkTla«rc«rT, aon-erposed
ccntrols
Significant difference at P < 0.095
level.
viitto KIIGDOB: IOOITSI BIOOB;
CtHTISTBT: tEBCOSI; REKCOBT OSGIHIC
COBPOHIBS: Eioiccginunoi:
CCCOPMIOflt B1TISDS

BEFEHERCE
Cross, J*D.
Dale, I.I.
eoolvard, L.
lenlhan, J.a.i.
Smith. B.
1978
lancet 2(80811:312-313


-------
larcarr(1»>. Mtkrl-. ioa 18 ci)
aerCeTTd*!. a»tkyl- f9 CI)
SJ96T-92-6
C-B3-Bg
II 215. S3
nssa
«2M
(rail
424*
Brain
«250
laic
4251
••art
«2S2
Ildaey
ZIKSDBB MOT
laoastlon
lakaUtioa
Ingest Ion
Ingaation
Inhalation
gestioa
estion
•latin
1I11RXC11
8 FT BOD
n
sc
u
sc
t
IDS EH
or cis:
7
9
T


Ufa
2-26 ns/» freak it
17.9-1t«.0 ng/g rresk vt
270-1030 »g/g freak «t
ot applicable
26 ag/g freak «t
IEII i eniiii iiFomtioB i IERIIICB
i i
I i
9 ng/g fcesk «t 1 Ceeapatianally expoaed to inorganic t Kosta, I.
1 Eg ot living In exposed area t Zcleako, T.
I f Earaik. T.
t Ittopsles. Yugoslavian*, ages 19-75 I levstek. R.
1 ji | Deraelj. R.
1 | Eyrae. i.1.
I IID1ISTBI11 mtVTIOB; OCCDPIHOIU | 19?a
1 BltUDS; POPOtHIOf ZH050II; 1 coapacatlm stndi«a of
I ST18SEST: incoiT; HRCTBI C1G1IIC | Food and BavltoiMatal
1 CCIKrans; TOEOSUTI1; tDTOPSIIS; | Cootaalaatiaa.
I EIOOD; BB1II: 1CIDIBTS; LITIB; LtOMS: I Proceeiiings of a
| IOSCIXS; snm; TBTBOIO GIMPS | Syiposim k«U 1«
1 I otaniaal, Finland,
1 1 lagist 27-31, HT3
1 1
1 1
72.0 mg/g frask wt I tatopsias, c«gil«c eaBstmrs of fia-h I Cappon, C.J.
I ceataiaiaq >C.5 tpa total Bg 1 Saltk, J.c.
i . i net
t Canadian Indiana, aortkmst Ontario | Journal of Analytical
1 1 Toilcologj 5:99-98
f fisus; FOOD cotTiBinnoi: t
I lisreniit poiiinioi: POPDHTIOI i
| (IPOSm: 10 ML 1EEIS; USBll UllSi |
1 SITES poitmoi: BSKUJI: BIBCOBT t
I ciEiiic coRpcmDS: IEMT; IIBKIIS: i
1 IITIB; naCZBU; SPLBII; CUIDI; 1
1 10TOPSIBS 1
1 1
1 1
538 ng/g frank «t I Gccipatloinllr eipooea to Incrginic 1 Kosta, L.
I Bg oc living in erpoa«d area 1 Zelenko, r.
1 1 *a»ik, T.
1 litopsles, Tagoslariana, >g«a 19-75 I lerstek, 1.
1 Tr. 1 Berielj, I.
1 F Byrne, I.E.
1 HBDSTBIH EdLnHOI; OCCaPITIOlU F 197*
I imiDS; POPOllTIOB RKSOBB; 1 coaparstiw stadias of
1 SUBCXBT: HBBCOBI: BBBCOBT OBUBtC 1 rood and ZBTiconaantal
1 cetpcuiDS; lososiiTH: IUTOPSIES: i coataalnation.
I ciooo; ism; riciiTs; LITSB; IOTGS: i Pcocwsatags of a
1 BIfCIBS: SP1ZEI; THTBOIB 6IIIOS 1 Sraposiaa held in
1 1 otulani, Finland,
1 1 lagiat 27-31. 1973
« •
1 1
7.6 n«/g freak at 1 utopsy, ragalar conaaier of tlA ^ cappoa. C.J.
1 containing >0. 5 ppa total Hg | Snith, J.c.
1 1 1981
I Ciaidlu ndiin, nortinest Ontario 1 Journal of analytical
1 1 Toxicology 5:90-9*
I TISHIS: FOOD COITHIUTIOI; |
I utosTBiai. tavmot; POPTOIIIOI i
I fieosmx; BUIIL HBIS; UEBII IBBIS; i
i iiTm poLKnioi; BiROJsi; SIBCIBT i
| C5S11IC COIECOnS; BI1BT; KIEPBTS; 1
t 1ITCB: MICEBTl; SPLHI; C1I1D1: I
I inOFSIIS 1
1 1
1 1
ng/g freak at 1 Cccapatloaally expoaei to inorganic 1 Koata, L.
j Hg or liTinq la axpoaed area 1 Zeleako, T.
I t Barnik. T.
1 latopaien, Tigoalaiiaas, ages 19-75 I leratak, R.
1 It 1 DcrielJ, 1.
1 1 Brno. l.l.
I XIBOStBtll POIlUTIOl; OCCBtiTTOnU. | 197«
| BltHIS; POPOLITI01 KPJSini!; 1 Comparative stadias of
I S08SCTI; moral: IBBCVBT OBGHIC 1 Food and Environmental
1 ccipoaiDS; TIOOSUTII; IOTOISIBS: i contiaiaatlon.
I I1QOO: BtUI: KIBRTS; tITIB: 1OTGS; | proceedings of a
| IDStttS; SPttM: TBT80ID GL1B9S 1 Syaposiaa kali ia
I I Otaaleai, FinlaiS,
| 1 lagut 27-31. 1973
1 1
                                                                                                                                                                                     00
                                                                                  tmtn fast)
-------
i«rcacT<1»l, Mtlrl-* too It ci)
«erc«TT(t»|, awtkyl- f9 CI)
S!«67-92-«
C-B3-B.J
M S1S.S3
1IS30I

•253
Eidney









425*
Liver












•255
Liver










•25«
Ilacenta










•257
Spleen










inosm son!

Tngeatioa









laoaatlon
laaalaUm












Invention























Ingeatioi











llaUTICal
BET BOD
8C









n












ac











oc











oc











HJB8SS
OF C1SIS
1









7












1











3











1











MKI

•at applicable









10-28 ng/g freak «t












lot applicable











15.6—28.0 ng/g fresk vt











lot applicable











mi

78.1 mg/g freaa it









18 »g/g frank vt












95.5 mg/g fr«sk vt











22.3 mg/g freah vt











IOC. 5 mg/g freak vt











eilEIiL IIFOtRlIIOI

la-topsy, regalar canatier of flak
coatalalaq >O.S cpn total Bg

Canadian Indiana, nortkmat Ontario
MS BBS; FOOD CORUIUTIOI;
iiBvsrtitt vountioi; rornLanoi
MPOSUt!: BOBIL atlas; tJBBll »E1S;
IITEI potumot; mean; BBICOBT
CEGMIC COB»Onos; BMBT; KIC1BIS;
IITCT; TLUXRa: SH.E1": CHUIl;
lOTOFSISS
Cccnpatlonally expoaad to inorqanic
tq or llTi««j In exposed ar«a

latopsles, TaooBlavinns, aoea 19-75
Tt

HDUSTBUt fCllDTIOl! OCCVFHIOIU
HIlllOS; POfOItTIOI 0FOSDBI;
SOBSEBT; BEBCVBI; 1EBCOEI 0161VIC
CCtPOTIBS; TOGOStlTIl; ITTOPSKS:
HOOD: saiti: EIBIBTS: LITEB; inss;
"BECLIS; SPLEER; THIBOtt SHIDS


Ktopsy, raqilar cognaec of flsk
caitalninq >O.S tpn total tg

Canadian Indian, northvent Ontario

fl!B»S: FOOD conuinnoB:
iiDOSTiiai FcunnoB: POPOHTIOI
MPO50BB; KOIU, US1S: IBB 11 atElS;
IIIH paiivrioi; niaisT: SCTCOII
tsaiiic coBFcnos; HEIST: Kmsis:
ITTEl; ?L1CIR1: SP1EM: CII1DI;
1BTOPSIE3
fletkyl predaalnnnt focn (56.9M in
afaciaens

lealdeats of hlgkly IndutrlallTed
ax«a
IISIES; FOOD COITl»I»TIOl;
IIDOSTIIll FCLLVnOI; POFOL1TIOI
tlPOSBBE: tdi»L 1BE1S: 08B1B IB 'IS;
imn pounioi; nEBCOBi: BSBCuirr
CSSIIIC COBPCBIDS; BB1BT; KIKETS;
IITER; FUCIIM; SPLIEI; CU1D1;
1BTOI3I1S
lotoptf. reanlar coaannar of fiat
eeatainlng >O.S cpa total tg

Caaadlan Indians, nortkveat Ontario

IISBBS; FOCI CORHIMTIOI:
IIDOSTBI1I FOLLOTtOB; POPBI.JII01
Eiioson: BOBIL »EIS: OIBII tsiis;
IITEI POtllJTIOl: SEBCOSt: HEBcaBT
CtSlIIC CO8FCOTOS; 1X1R; KIDIITS;
IJTEPl mctRl: SFIZEB: C1UDI:
10TCISIES
BEFEEiBCE

Cappon, C.J.
snitk. J.c.
1981
Joaraal of analytical
lox oology -.90-98






Koata, I_
taTnlk.*T.
tCTBtex, H.
Dernel^. B.
Byrna, 1.1.
197 •
Coaparatln 3 1 alias of
Food and Environaental
Contaa {nation.
Proceed Ings of a
Synposlaa held in
Otanleai, Finland,
lagwt 27-31. 1973
Cappoi, C.J.
Saitk, J.c.
1981
Journal of analytical
Toxicology 5:90-98







Cappoa, C.J.
Saitk. J.C.
1981
Joaraal of analytical
Toxicology 5:90-98







Cappon, C.J.
Snitk, J.C.
1981
Joaraal of analytical
Toxicology 5:90-98







                                                                                                                                                                                         \O
-------
              £ CD
  Benzene, 1,3.5-triaethyl- (» CT)

  C1-H12
  •1 120.2. m -»».8 C. BP 1««.T C. TP 10 •• 89 at «7.« C
1ISS0B
(258
Breatk










«2S9
Breatk











EMOSOSB ROOT]
























1U1ITICU
BETBOD
8C/BS











GC-BS











BOBBER
OF CASES
8











54 (317
sa«pl«3)











I1IGE
lot detect«d-0.81 a«/hr











Mot 9lT«a











BE1I
0.12 ngyhr











O.S*2 ng/1
Gcowtcic










1
6»»1I IK01BITIOI
Ccipoaid related to >orial
Ktabollsi. lo otk«r tetalli qlrea
Cryogenic »»ipllttq technlqa..

8«althy aili tar T and ciTillaa
•iploreea, o.s. air Force School of
lerospaee «edicia«. ag«s 23-«7 ji. 3
siokers.
EflXnsS; CBIOBIIUBI HTDSOC1BBOHSJ
cnottiiB oieinc coipomms:
CE1CROBNZIIIS; FIOOIIIE COBPOOIDS;
CBI1T8; HCCBOLS; IET15; IDBITS
taanr«a at 25 C a«d 7 SO IB Rg
32.CV occurrence
to««r and upper ox-SlgBa lliita
0.327 »Dd 2.16 aa/1

Realtky, 18-35 yr old, nonsBokiaq,
artaa blacks aid caacactans.
Ckicaga. n. Biqillr controlled
experimental conditions.
flint; itccNts; IIIIBOIS; IDUITS;
CBICBIUTfO BIDBOCtlBOIS: T011THE
CBGIITC COSfCOIDS; HE11TB B1Z1ROS;
IIBtHTIOB: IRaBOlISI: IET1EOLITES:
EC?OHTTO» JUOSOIE; 3SB»B IBEaS
BEfEBEBCI
ConUe, J.P.
Caip, B.J.
Mick, B.E.
197S
irefciwea of
EnTironaeotal Bealth
30 (2): 290-2*5





Krotasiuwki, B.K.
Braaeav. e.R.
O'Heill, B.J.
1»7»
Journal of analytical
Toxicolovr 3:225-23*







                                                                                                                                                                                           N)
                                                                                                                                                                                           M
                                                                                                                                                                                           O
Ictkam
7»-82-8
C-H*
BI 16.05, B? -182.6 C, BP -161.5 C, TP «00 » Sg at -168.8 C
IISSOB

•260
Breath



ElfOSDB! KODTI





1
1B1LTTIC1I
RETBOD
ec/«s




BOBBIB
or cisEs
43




SMGE

0-32 PPI




R»l

S.1 ppa



1
I
GCBIIll IIPOBBKIOI

Corrected for lerel in inkalefl air

Eealtky adults
SIBBEB; 1 DOITS; HE»SBBE9EII IETRODS;
IIIR1BOL
EEYEREVCE

Jansson, B.O.
larsson, B. T.
1»69
Joarnal of Laboratory
and Clinical Bet hods
7«(6):>61-966
-------
Betkan, dlcUoro-
75-09-2
C-BJ-C12
•1 »».»«, BP -95.1 C,  BP 39.75 C.  TP 3(0 «• Bq at 22 C
TISSUE
«2C1
Breath










RPOSOtl SOOTE












ivaiRicii
BBTHOD
SC/HS











BOnBES
or cisss
8











MKC
lot tetected-3*0.0 og/»r











BM.B
55.0 ag/kr











SEBtML IlTOIBmOl
IrplOYM>> 0.3. iir POTOB School of
Icrospac* B«aiciae, a««s 23-»7 jr. 3
xaokaxs.
intnR; cBioiniTit nnocuiBOis:
cnoim OBEIKC COBPOOWS;
CBiowjEEiitiis: nnoBin coiMons;
iiena: ncflfiois; THIS; irons
XXriBBlCE
CODkl«, J.P.
Caapv B. 3.
Mick. 3.1.
iris
lrckiT«s of
EMironB»nt»l Health
30 (U -.290-295





         4icUoro«itlvoro-
TS-71-S
C-C12-P2 .
B<  120.92, BP -15B C. SP -29 C, TF S at* at t6.1 C
TISSJS
«262

I2C3
tile

•26»
Blood

• 265
Hood

MPOSBR BOOH |
1
Inhalation

Inhalation

Inhalation

inhalation

amiTIClt
BETBOD
ac

oc

BC

taiioaetcy

BtriBZI
OP CISSS
1

1

t

1

1HGB
lot applicable

Bot applicable

lot applicable

0.5-0 ng/al
(«BW
sail
13 »g/g vet «t

13 ng/g «et *t
_
1.2 og/g vet «t

lot applicable
PIGB)
Gill HI IBrOlBinOl
Ceeatae. litopsy sanple. Death 1.S
kt after sniffing cooking spear.
Bale, age 13 jr. kt 62.5 in.
11BOPSIBS: IDTPOSB IISS01; BILB;
EtCOD; 9B1II; HEIST; IXDIBTS: LITIB;
miss; anscus; CHIOKHTEP
BTtBOClBSOIS; P1IOIIBB COBPOOBBS
latops*. leatk 1.5 fcr after sniffing
cooking spray.
Bale, age 13 yr, kt 62.5 In.
itrtopsiES; itiposs tissBi; BUS:
EIOCD; BB1IB; B!»BT; KIDIITS: LITEB;
lUfCS; in SC1K: CBLOBIBaTBD
ItBSOCHSOIS; PtOOIIBI COBPOOTDS
Beart blood, lutops) sanple. Beath
1.! fcr after, cooking spray.
Bale, age 13 yr. kt (2.5 In.
i BIOPSIES; mpos: nssoE; BUB;
E100I; BttlB; BXUT; KID IBIS; 1ITEB:
mass; aoscLis; CBLOBIHTBD
ETDBOC11BCIS; TIDOBIIS COItOOIDS
It ani 5* ain after »S.» ag/aln,
16,75 ein. Initial neastirenent, .05
og/al at 0 tine. Bstlaated froa
graph.
HOOD; PLBCBIIE COBfOIIIOS; it BITS;
BiismaBn BITBODS
i


Staadefer, J.c.
1975
Journal of Porensic
Sciences 20(3) :S*8-551

Staadefer, J.C.
1975
Journal of Forensic
Sciences 20 (3) : 5*8-551

Staadefer, J.c.
1975
Journal of Forensic
Sciences 20 (3) :S»8-551

idle, J.
Blake, D.A.
mrgnar. C. B.
1975
Journal of Clinical
Pkaraacologr 15:760-770

                                                                                                                                                                                         N>
                                                                                                                                                                                         K)
-------
gathane, Aicaloroaiflaoro-
75-71-t
C-C12-M
•I 120.92, Ii -15S C, BP -2* C. f» 5 ata at 1C. 1 C
                                                                                     (COITIIOED)
tissos
•2CC
Braia
«267
Boart
«26«
Eiaaey
•269
Lime
«270
laao
»271
Basel*
EIPOSBIS BOB
inkalation
Isaalatioa
Inhalation
Inhalation
ahalation
halation
aULRICaL
RBTHOD
ec
sc
ec
ec
ec

EBB BBS
or cisES
1
1
1
1


BaiGE
lot applicable
lot applicable
lot applicable
lot applicable
at applicable
ot applicable
BE»B i 6BMUL iBFOBRinoi i BBFBBBBCB
i i
3.5 ag/g vet vt | latopsy. Death 1.5 kc after saiffiag I Staaoafer. J.C.
1 eeeklaq spray. | 1*75
1 - | Joaraal of Forensic
1 Bale, age 13 yr. kt 62.5 la. I Sciences 20 (3) sSa.8-551
1 1
| IHTOPSIES; 1CIPOSE TISSUE; BUZ; |
1 HOOD; BSIIl; BEaBT; KIDISTS; LITBB: |
1 igies: insciis: cnoiiuTsu i
| BTDBOCI8BOIS; TIOOBIK CORtOOIDS I
1 1
1 1
1(0 ag/a rat ot I Mtop«T. Death 1.S he after sa iff ing I Staadefer, J.C.
1 cockiiq spray. I 1975
1 1 Jouraal of Foreasic
1 Bale, age 13 yr. at «2.5 ia. I Scieaces 20 J3) :5«8-551 •
1 1
1 IOTOTSIS5: IBIPOSE TISSOI; BUB; I
1 tXOOD; gsillj BHST; KI01ETS; 1ITSS; |
1 miss; nosciis: CILOSIHTBD i
1 iToiocmcis; rinosui COBPOOWDS i
i i
i i
S.« 09/9 vet «t I latopsy. . Death 1.5 hr after sniffing | Staatefer, J.C.
1 cookli
-------
 Mtkeie,  ilcHoiotlmaro-
c-s-cu-r
II 103, »P -US C.  It «.9 C.  TP 2 at!  «t  28. « C
1ISSOE
•272
inttk










EirosoiE BOVTE



-








1U1TTIC1L
BZT80D
OC/HS










-
•01MB
or cisss
i











MICE
Bot OeteCted-0.062 ng/kr











SB1I
0.025 aj/kr











GEIZUL moiBaTxoi
Previous exposare to coipoavd. Bo
cthar ietaili gt*«tt
Cryogenic xanpling tecknigee.

ttaltkr illitMT ni clilliai
aneloyees, O.S. lir roree School of
aerospace Bedicine. ages 23-47 re. 3
(Mints.
««ii!3: cBioniaiBD nmociBBOBS;
cnomi oBCinc COBPOOBBS;
CBlCBOBntZBK; nOOIIBE COBMOBDS;
fBUTB; 11CCBOIS: THIS; 1 DOLTS
BZiniBCI
COBlEle. J.P.
Cup, E.O.
»«lck, B.Z.
1975
»rchl>*» of
EBTiroiMita.1 B«alth
3U(2):290-295





B«tb*M, dicHotomltio-
7119-89-3
C-B-C12-B-02
B1 129.93, BP 107 C
tissn

•273
Btutk












BIIOSIIBE Ksm















llltTTICtl |
BBTBCD |
1

SC-B3













IBS BIS |
01 cists i

» <3»7
•upl«s)











-
B1KI |

Bot ?lY«a













BB1B |
1
1
I
6».1 ug/l
Saoietric











_
CtllllL 1BPOBHTIOB

I«»mc*d at 25 C «»a 7CO mm eg
2*.St occncc«iic*
Io«• Bg. -23.0 C at 100 ma Bg. -32.3 C at SO ai Bg.  -39.0 C  at «0  n  Bg. -19.7 C at 20 la Rg, -59.0 C
 at 10 n Bg.  -«7.6 C at 5 •• flg. 8«.3 C at 1.0  u Bg
1ISSVB
*27«
»4ipo»«

•275
all*


IXIOSBIE Bonn
Inkalatlon

lakalation


kBllTIlCll
BBTBOg
ac

ac


BOBBS5
OF CISSS
1

1


BIB6B
Bot applicable

Sot applicable

(BUT
SE1I
1.7 «g/g net lit

-
3. 3 ug/g vet vt

tKtt
GEBttal IBrOIBlTIOl
CaaBtai. autops> aaapl«. gcatt 1.5
kx aft«r sniffing cooking spiay.
Bal«, «g« 13 71, at 62.5 la.
•Dtcpsies: IDIPOSE tissoj: BILE:
HOCO; B11II; BEJtT; KI9BZTS; I.ITB1;
LOISS; 4VSCIES; CBLOEIBaTEO
HDtocmcis; rmoiiii COBPODBSS
latopsT saapl*. Doatk 1.5 Ir after
:«lffltg cooking sptay.
Bale, age 13 rr, kt 62.5 in.
11IOPSIES; ItlPOSE TXSSOE: BILE;
MOOD; BI1IB: BEAK; KIBBEIS; 1ITIB;
ICISS; BOSC1IS; CfrtOSHlTID
BTBtOCaSBOBS: TLDOBItE COBIOOI95

BE7EBEBCE
Stantefer, I.e.
197-i
Joornal of Tocensic
Sciences 20 |3) sSM-551

Standefer. J.c.
1975
Jooraal of rot en sic
sciences 20(3) :S*8-551


-------
Ettaane, trlcUoroflaoro-
7«-69-a
C-C13-»
C-C13-»

n 137.38. BP -111 C, BP 23.7 C at 760 •• Hg, «.l C at »00 ll Bg. -9.1 C at 200 •• ig. -2'3.0 C at 100 •• Bg. -32.3 C  at  «0  ••  Bg, -39.0 C at *0  u Bg. -M.7 C at 20 aa Bg. -59.0 C
at 10 aa Bg. -67.6 C at S aa Bg, 8*.3 C at 1.0 aa Hg
                                                                                     (COIIIBIEO)



























TISSUE


a27«
Mood







•277
Blood






•278
Era! a





J
1 «279
1 Breath
EIPOSUBS BOOT


lakalation








Inhalation







Inhalation









1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1

12*0
Beart







•211 I
Ildney









Inhalation








n halation









lEUYXICIt
BETBOD

OC








Badioaetry







ec







SC/HS













6C








X









BHBBEX
or CASES

i








2







1







•
HBGS


Bot applicable








0.8-.05 ag/il







Bot applicable







Bot detected-O.Otl ag/kr













i


























Bot applicable








lot applicable









BE1E


0.6 ag/g vet vt








Bot applicable







0.5 ag/g vet vt







0.011 ag/hr







GZBIS11 IBFOBBITICB 1 BEFEBZBCB
1
1
1
Beart blood, latopay saaple. Death I standefer, J.C.
1.5 hr after sniffing cooking spray. 1 1975
I Joarnal of forensic
Bale, age 13 yr. kt 62.5 in. I Sciences 20 (3) :5»8-551
1
ROTOPSISS; IMPOSE TISSUE; BUB; |
ElOOD; BB1IB; BE1BT; KIDBBTS; I. IT SB; I
tU»GS; BDSCIES; CR10BIMTED |
BIOIOCtBBOBS; FIOOBIBS COBPOOBDS I
1
0.25 and 1.5 hr after 35.6 ag/lin, I Idir. J.
13.75 nin. Initial neasareaent, .05 I Blake, 0.1.
og/nl at 0 tlae. Zstiaated froa I Bergner, 6.B.
gtaph. | 1975
1 Jonraal of Clinical
Sabjeets weighing 63.0 and 95.0 kg I Pharaacology 15:760-770
EIOCD; TIDOBIBE COHPOIBOS; 10DIIS: |
BIlSmnSBT BRBODS 1
1
latopsy saaple. Death 1.5 hr after I Standefer, J.C.
miffing cooking spray. | 1975
1 Joarnal of Forensic
Bale, age 13 yr. ht 62.5 in. I Sciences 20 (3) :5«8-551
IOTOPSIES; 1BCTOSE TISSUE; BILE; I
6IOOD: BS1IB; BEUT; KIDBETS; LITBS; I
miss; nnscits; CHLOHEITED i
BTEBOC1BBOBS; FLDOB1BB COBPOOBDS I
Previous exposure to eoapoand. Bo I Conkle, J.P.
ether detail! given | Caap, B.J.
Cryogenic saapling technlgoe. | Belch. B.I.
| 1975
ealtky ailltary and civilian | Archives of
aployees, D.s. Jir Force School of 1 Environaental Health
erospace ncdiclne, ages 23-07 yr. 3 | 30(2) : 290-295
aokers. i
1 j
1 IIBZEHS: CBICBIB1TEB BTDBOC1BBOBS; |
1 C8LORIH5 OBG1BT.C COXPOOBDS; I
1 CBICBOIEBZIBIS: FLOOBIIE COBPOOBDS; 1
1 MEMS; tICOBOlS; THUS; 1 DOITS |
1 1
»9 ag/g vet | litopsy saaple. Deatk 1.5 hr after I Staadefer, J.C.
1 aniffiag eookiag spray. j 1975
1 I Joarnal of Forensic
I Bale, age 13 yr, ht 62.5 ia. I Sciences 20(3) : 5*8-551
1 1
1 IBTOPSIES; 1BIPOSS TISSUE: BILE: |
1 E1COD; BB1IB; BUST; KXDBETS; LXT3S; I
1 iftias; lascus: cmoEimiED i
1 BYBTCCISBOBS; FLOOSIE! COBCOOBOS I
1.1 ag/g vet vt I latopsy saaple. Deatk 1.5 hr after 1 Staadefer. J.C.
1 sniffing eookiag spray. | 1975
1 1 Joarnal of Forensic
1 Bale, age 13 yr, ht 62.5 ia. f Sciences 20 (3) :5as-5S1
1 1
I IVTCTSIBS: IIIPOSI TISSUE; Bill; 1
1 IICCD; BBiiB: asm; IIDIEIS: LITXB; i
| 11B6S; 10SCIZS; CBLOHEHED |
1 BTtBOCIBBOBS; FtOOBIBB COBPOUEDS |
1 1
(BUT PIG I)
-------
(etk»e, trickloroflaoro-
c-ew-i

*! II7'31! "JJ'J  S'  ?«23-7.c  *hTf*  ™ M'.*-9 c •* *°°
at iw •• Ha*  -«7.o  c at  5  •• H0p Ba.j C at  1*0 M 09
C at 200 aa Bg,  -23.0 C at  100 *• eg. -32.3 c at 60 aa  Bo;. -3».o C at «0 aa Bg. -»9.7 c at 20 aa Eg, -59.9 c

              (COHXB9ZD)
I13SDJ
•282
liT*T

•2«3
HM

•2M
•i«cle

Einsnit mm
XaaaLatioa

I«k»lation

iBkalatlon

lUlRICtl
nnoD
ec

oc

sc

I0BB1B
or cisis
i

i

i

IM6S
lot applicable

lot applicable

lot applicable

am
2.9 »g/9 nt it

3S «g/j wt »t

0. S og/g nt nt

eiinii nmutxoi
•
IstoptT s&ipl«. B«ath 1.5 ar attar
>al((iiq cockim spray.
B«l«, aq« 13 TT, at «2.5 la.
uncpsiis; iBirosi nssos: BH.Z;
noctj BBHI; nm; KIBRTS; IITSB;
miss: loscizs: CHIOIIHTII
(iriociiaois; riooim COB pom DS
Igtopar saaplo. Itaatk 1.5 kc attar
•ilffiaq cooking spray-
«al«, aq* 13 rr. kt 62.5 in.
inopsus; IBIPOSI nssoii BUS;
ttOOBt nut; RE»«; ttgrttS; IITEB;
tnies; 10 sens: cnoBiittn
IIB10C1BB01S; TUOKK COBPOimOS
lliopaoaa. iDtopsr Mipla. Death
1.5 kt aCt«i miltiBq cookiag >pcaT*
lal«, ago 13 rr. at 62.5 in.
inopsus; (iiFOSi nssoii BIU;
noco; BtiiB: Bum; KIBIITS; LITBB;
linos: ASCIIS; CHLOSIHTII)
StDtOCIBBOIS; riBOSIU COBPOIWDS
Btrnmct
sta>a*f«. i.e.
1»7S
. Journal of rorauie
Sciences 20 (3) :S«S-551

st»oa«t«, J.C.
1»75
Joarul of Porenslc
Sci«K«« 20(3) :5««-5S1

st»»a«t«r, j.c.
1975
Joutnal of Forensic
Sciences 20(3):5I>I-551

                                                                                                                                                                                        M
                                                                                                                                                                                        KJ
                                                                                                                                                                                        Ul
          soaie add  (8 CI)
  ccoaie «cia, MthTl-  (9 CI)
  :t-se-3
  -H5-1S-O3
  B 139.96.  BE Ul C

(585
TliM










EIEOSOB; BOOTB











IHILTIICU
BETBOD











ROB BIB
or cisss
a) 9
b) ia










IllttJ
a) tat qlm
b) lot gi?«n









	
BS1B
-
a) 1.7 ag/g
ccaatijtina
b| 5.2 u
-------
   Retkanol
   C-BB-0
   •t 32.0*,  IP -»?.§ C, BP «».7 C
IISSUI

«28«
tieatfc




«2«7
Sreatk










•28.
Breatk











ixposin* ton
































iHinxui
BBTBOD
er/BS





oc/as











ec-as












inaan
or CUES






,











5» (387
saaplea)











laKX

0.27-3.39 ppa





lot d«tect«d-2C.O of/kc











>Ot flT«B












Bill

1.0S ppa





3.7 «j/»r











0.5*9 ag/1
SeoHtcic











GsisiiL laroiaitioi

Corrected for level la inhaled air

Eealthr adults

sum: icons; BMSTntBssiT BSTEODS;
IITB1IOL
Ceitoma related to aoraal
•etabolia*. »o otler details ging
Cryo^eaic saapliaf ^ecnnla^tt.

Bealthr ailitary and elviliaa
aaplorees. U.S. air Force School of
texospace Beflcin, aqes 23-47 TT. 3
stokers.
Eiitms: caiointTEO BTDIOCISBOXS;
CBIOSHI oaeiaic COHPOOIDS;
CEietoBinziijs: nvom: coapouwss:
SMITH; itcceois: TBUS; IDOITS
ttaaared at 25 C atd 760 aa Kg
3.61 occurrence
Io«er BBS nfper one-Si gaa liaits
0.1S1 and 1.99 B9/1

a«altkr. 18-35 jt oil, QOHBackia<7.
ortaa blacks a»d Caucasians.
Ckicsgo, It. Biqidlr controlled
eipcrlaaatal coalitioaa.
IlflTI; 11CCBOLS; IILIWOIS; 1001TS;
CBtCSIHIID BTDBOCIBBOIS: »OHTH!
ciGinc coBconos; BIUTI BIIHDS:
IIB1UTIOI; BIT1MLISI: BETIEOLITZS;
topniTioi iiposraa; USBJI IEEIS
BIWSEICI

Janaaoa. B.o.
IBTSSOI. B.T.
19«9
Joacaal of laboratory
and Clinical Retools
74(K):9«1-9«6
Coakle, J.P.
Caapr S.J.
Velch, B.E.
1975
ftrckives of
EBTiroBMBtal Healtk
30 (2); 2*0-295





KrotoaziBaki. B. K.
Braaeag, G.I.
O'leill, B.J.
1979
Journal of iBaljtical
Toxicologr 3:225-23*







                                                                                                                                                                                            CT-
       
-------
       tUmllit* t» ct)
      id*. Martin (* CD
c:*-»2-o
C2-M-S2
§1 91.2,  It 109.7 C, If 26.«  II B« It 25 C
                                                                                  (conitmq
I1SSBI
•290
Bmtk










IIMSWI MHI











llllttlClt
•BTRQD
SC-BJ










OF C1SIS
54 (3*7
aaipl**)










I»GB
lot 9lT«a









	
BMl
1.9* mo,/l
Ceoaetric










6EBZB1I IBTOBBaTIOB
C«*m*4 at 25 C aal 7(0 •• tg
33. 1* occarreace
leMr aal upper oa«-Sloaa Ualts
C.M7 aal 7.M mg/1
lealtkv. It- 35 TC oli. muokiag,
ortai bltcki aid cancailua.
cticaqo, II. ilqidly controlled
tiperliettal eoailtioac.
Him: HCCHOIS! tUIMUt UHUS;
CitOIIHTZt mtOCIIBOISi TOHTHE
ClCinC COBPCBIPS; BMIT8 IKllDS;
HBlIAtlOtt BITIBOIISI; B««O11TSS:
wjniitioi zttoson: niui mis
nnmcB
Itotonnaii, g.i.
Bcneai. «.B.
O'leltl. B.J.
1979
Jonraal of aulytical
Tozleolo«f 3:225-23*







 «thil cdlflte  (9 ci)
 «thu«, tUcbl*- (« CI|
 I-U-3
 J-tt-S
 1 (2.11, n -13.2 C. IP 37.5-31 C
TXSSVt
• 291
Bnatk








•292
Bieatk











EXtosni Konti






















lUtTTICll
-IRBOI
OC/HS









oc-as











IUBBM
or cases
t









S« (3(7
•aiplu)











MICE
-
lot fletecteS-53.0 aq/nr









lot ^iTen











«..
17.6 ij/hr









Seowtrlc











SlltUt IR01BKIOI
-
Coepoeil related to lonal
aatabollai. la other details qln*
CrTOTealc laipliaq teck&l^ae.

lealth? illttatr ui ciTili«
•iploraM, n.s. air Face* School of
»ero«j>ac« Mdlei**. aoejs 23-*7 It. 3
disnts: cBioBiiiTjo BTDBOCWIOIS;
cnotin oicinc COBPODIDSI
ciiotoimms; nnoiriE coBfonns;
E1I1T9: I1CCB01S; TZI1S; 1EB11S
Pea«mred at 25 C ai4 7CO •• Bg
M.«% ocemnaca
lover nd «ipac ow-Sloai Halt* 0.*2
aid 2.30 aa/1

Bcaltkr. 16-35 TC old. noBHokiaa.
•tin bltclii aid eaaeasla**.
Chicago, II. BigldlT coitrolled
•iperiwatal conUtioia.
flZlTB; IICOMIS; IIUIOIS: IOOIIS;
cnoiiiktie iniociBBaiSi Toitins
ciemc coBpcutDS; BIU.TB IMIBIS:
uiiUTiai: RTiBoiisi: BEIIWLITH:
EQIOUTIOB ZmsgiE; BJBal 11IM
MIBMBCI
coikla). J.P.
caip, B.J.
Mich. B.I.
1975
lreki*e* of
EUTlTouatal Health
30 |2): 290-295




Krotoatimeltl, B.K.
Bruaaa, e. R.
c'lelll, B.J.
1979
Joarial of analTtieal
Toilcologj 3:225-23*







                                                                                                                                                                                   NJ
                                                                                                                                                                                   NJ
-------
ItV 95.94, If 2622 C, BP «25 C (appro*] , TP 1 •• Hg at 3300 C, 10 •• Eg at 3770 C































1ISSDI

•293
Blood,
(hole








»2»4
Siir
















IIPOSOEJ BOOT

































«295
Kidney

1
1
1
1




















1IUTTICU
RETBCD
































It





















IUBBSB
or ciSBS
w




























IMBB

0.50-15.73 ng/100 al































) * a) 0.072-0.67 tg/g
) 9 b) 0.0*0-0. «1 ua/g
c) 10 c) 0.069-0.24 ng/g
let vt


















BEtB i GEiim iirtnunoi
1
•ot given 1 lange of aeau. snltiple aaaplea fro
1 9 collection cites in the U.S.
1
1 SIIHTUS: aOIIBBUTTB: TUIDIBS:
1 HOOD; SEX: SOOTB BlKOTi: IE* TOBIt:
1 iiCBlie: mKMi: OHIO; KISSISSIPPI:
1 1II1S; SOBTB D1ICOT1; I1SHII6TOH;
1 C1LIPOSIII: lEIZOH; 1191111;
f lOVISTUl; IBM ISIS; FWBIDI;
1 TIB SOrl; TB1CI EIEIEITS
t
i Bevlev. 24 repreaeatatlve
1 pte-analysis treatunts arc
1 tabelated. The feesibiltty of a
1 holistic, no-wash policy for hair
1 analysis is oetliaed and supported.
1 ItTIEIi T*1CI EtMHTS; HUE;
I itsnuij; BiisusBsn BFTBODS;
I riTus; PFOIHIS: CORPIUIITE
1 ITllniTIOIS: 1HTBII09; lITIIOiy;
1 IISZBIC; B1B1US; BBOK1T: ClHIItlH:
1 CI1CI0B; CBIOBIRE; CEBOBIDB; C011LT;
1 CCFPEB: GII1HI": SEtBHTDB; GOLD:
1 10DIII; ISOI; UtTHiIld; Llir;
1 (IGIESTVar BlKalESB; BttCOBI:
1 iciTEDinB: IICKH; psospuoins:
1 POIISSI5B: BOBIDI0B; SELEIIB1:
I siivxa; SIITEB: SODIOH; STBCITIOI;
1 SDirjB; TII; TITHIDB; TDIGSTEI;
I inc; IIBCOIOB
1
1
a) 0.22 ng/g F a) Controls
b) 0. 19 ng/g I b) vortor grcup I
I 0. 10 ng/g I c) loiter grenp II
let ft I
edians I teceased refinery and seelter
1 1 netkers, ages 55-76 yr. exposed to
1 1 hiavy aetals 1-3 decades, liee
f f netwen retirement and death 0-1.5 yr
1 1 it gro«p I a«d 2-19 yr, group II.
1 controls, ages 43-72 yr, vho lived 50
1 ki frei the factory- sneden.
1 SI!B!»: C1D1TEIS; IIDIXTS; IITZR;
1 ICISS: C01FIUTIVE ETaHUIIOBS;
1 IIDOSTtlll BTSIEK: BBISDJBBOTT
1 9ITBODS: IITIBOIT: IBS MIC; C1DIHFS:
I CISIOB: cHBomr»f COBJLT: COFPBI;
t GOir; HOI; I1RB1IOH; LE»:
1 eiIGI«ESt: BKCOBT; HOLTBIIaim;
1 CBOSPBOBOS; BDBIDTDR; SC1IDIOB:
1 sniBin: SIITEB; TII; TBIGSTH:
1 ZIIC: BMITB B1Z11DS; IKDOSTBH1
1 PURS: SRIlTtBS: TEllmiOR
BIHBEJCI

illa«»j, I. H.
Xnbota, J.
Loses, P.
Roth, B.
1968
Archives of
Znvirouental Health
1S:342-3«t



Chittleborongh, G.
1980
Science ot the Total
EnTironnent 14:53-75

















Brnae, 9.
lordberg, G.
Hester, P.O.
1930
Science of the Total
Environment 16:13-35
















•MM PIS I) .-- ..
                                                                                                                                                                                        00
-------
 Boljbiftam
7«39-9»-7
Be
ttl 95.9«,  SI 2622 C,  Bt  41J5 C  (approi), TF 1 n Bg it 3300 C, 10 u fl» »t 3770 C
1IS5IE

4296
lifer




















4297
Into.





















EltOSBBE BOOK














































aEiimcu
BsTHOD






















U






















BBBBSB
OF CISIS
•J «
» 9
c| 10



















at B
W 9
c) 10




















E1KE

a) 0.34-1,24 ag/«;
b) 0.21-1. C9 ag/g
c) 0.22-1.33 ag/g
Vet vt


















a) 0.011-0.27 ng/g
b) 0.014-0.15 ag/g
c) 0.020-0.12 «g/g
Bet wt



















BBAB | GEEESal IBWBBHIOB
J
a) 0.5* og/j | a) Controls
b) 0.65 aj/g j b) Vorker group I
c) 0.4* eg/g | c) Borlnr groap n
Vet «t I
Sediaas j E«c«as«d refltery aid iMltet
1 workers, ages 55-76 yr, exposed to
j leavy aetals 1-3 decades. Ties
I tetween retireseat and leata 0-1.5 yr
1 la group I and 2-19 yr, groap II.
I Controls, ages 43-72 yr. HBO ll«ed SO
I ka fros tbe factory. Swedes.
1
1 SBECEV; CIDIfEBS; KIBBBTS; LITEB;
I 1VICS; COBPlBaTITB CTIIDITIOBS;
| IBtOSTEIal BI6IEBB; BIISOBIBCTT
1 BiTWBS: iniBOBi: wsnic; CIDBIDB;
| CESIBB: CBBOB3HB: COBaLI: COPPEB;
I SQID-. IKOB: laBTBlBBB; 1I»I;
| BIB6HSSE; BEECDB1: BOL13SEIOS;
| SELZEIOS: SIITEB; TIB; TOIGSTEI;
I IIBC; BE111B SlIltDS; IBSBSTUkl
| PI1BTS; SBEltltS; TBlLDBIOa
a) 0.030 og/g \ a) Controls
b) 0.027 ag/g I b) Barker groap I
c) 0.053 ag/g | c) Barker grcap II
Bet «t |
lediaas | Ceoeasei refinery aid snalter
| Markers, ages 55-76 yr. exposed to
I keary setals 1-3 decades, fine
| tit Men retirement and deatb 0-1.5 yr
1 IP groap I ail 2-1* yr. qroap II.
I Coatrols, ages »3-72 yr, >bo liied 50
1 kn fro* tbe factory. Sneden.
1
| SIEBEB; CaOlfBISi HIBI1IS; tITEl;
| IUI5S: COBPUITITS ITllUWIOBS:
| IBCBSnill BTGIEBE: BEISHBEBEBT
| SITBODS; tBTlBOBT; USIBIC; CUBTVB:
| CISTOI; CBBOaXBB; COBILT: COPPEB;
I SQLC; ISOB: il«TBi»OB; ISaC;
| BlBGtBISE: BE8COBT] B01TBDEBOB;
1 traspBOBus; svaioiai; scaioins;
I SltElini; SHIEB; Til: TOBSSTEB:
1 IIBC; BEalTB BailSDS; XBDOSlBIal
| PIlaTS; SBE1TEBS: TEllVBIOB
UFIIEBCS

BEtt&a, D.
Bordberg, G.
vaster, P.O.
1980
Science of the Total
EcTlroBicnt 16:13-35
















Bm&e. D.
lorjberg, s.
•eater, P.O.
1980
Science of tae Total
EiTtronneat 16:13-35

















                                                                                                                                                                                        KJ
                                                                                                                                                                                        NJ
                                                                                                                                                                                        VO
 Bapnthalene
 91-20-3
 C10-B8
 «I 128.16, BE 80.1 C.  B? 217.9 C.  TP 1  ae Hg at 52.6 C
IISSttE
4298
treat*












BirOSBBB BOOTE
-














imnicii
BET BOD
«C/BS













BBBBES
OF C1SBS
B













B11GE
Bot detect«d-2.» og/kr












(tin
8EAB
0.5 »j/hr











•
PISE)
GEIE81L tlPOBHTIOB
Ftflilots exposure to coipound. Bo
etner details qlTen
Cryoqeolc saapllat tecaniqae.

tcalthy nllltary and ciTiliai
eaployees, U.S. air Tocctt Scbool of
lerospaee Bedlclse, ages 23-47 yr. 3
linkers.
EIBZEBtS; CBIOBIHTfC BT9IOC1BBOBS ;
CE10H»! OBG1BIC COBPOtnilS;
CBIOBOIEIZEIES: FIOOTHS COBFOVBOS;
EII1TB; atCCBOLS; TE»S; ICO ITS


BSFEBEVCX
_ .. _
conkle, J.P.
Caap, t.3.
velch, B.E.
1975
lech ires of
EKTironaental Bealth
30 <2J! 290-295







-------
   Etpkthalanc
   SI-20-3
   C1C-H
   «V 12*.1C. IS 80.1 C, BP 217.9 C, TP 1 •• Hq at 52.6 C
                                                                                        (COBTIBDED)
TISSUE
«2»9
Snatk













nPOSTOE HOOTI















IBIinXCIL
BBTBOD
60-a s














EVBBBB
OF cms
54 f3»7
aaaplcs]













EtIGS
lot alra












I
I
«u
9.772 as/1
Seoaetrlc











1
1
6EEZB1L IBTOBBITIOE
••••ami at 25 C ud 760 n Bg
98.9V occnTraaca)
Io»*r and apper OBB-slgaa Halts
0.335 and 1.T« ng/1

B«altkTr 11-35 JT tit, aoaaaoktog.
•tin blacks aad caneaaians.
Cklcago, II. tiglllr controlled
«rla«atal coaditiogs.
tltlTR: UCOBD1S; IIIHOIS; 1DO1TS;
ceiotniTio nomciiBois: IOHTHS
CI6IIIC COBFCOnSi BE11TH BtZtBCS;
IHIlIlTtOI; tETlBOlISB; BBTIBOLITSS;
PCP011TTOI IIPOSOBE; OMH 1BE1S

1E7EIIICZ
KcotonyBaki, B. K.
Bcnncaa. 6.1.
O'lWlll. B.I.
H7»
Joaraal of iBalytical
Tozioologr 3:225-2M







1
I
  lapattal«ii«, dlivtkyl-
  mo*-ae-a
  cii-Riz
  >• 156.23, « T.CC C.  BP 2«8 C
IISSUB
*300
Bnatk












I
BXPOS0U lOHTB














IBU.TTIC1I
HRIOD
SOBS













1
•OBBEB
or cisis
54 <3tT
saaiplas)













BM6B
lot giren














BB1B
0. 079 og/1
^eoaetric











GE1II1L IITOtllTIOB
E«a*tc«4 at 25 C aid 7(0 la Bj
36.2V occncMBce
lowac aad acpar one-Slgaa Halts
0.029 11 a 0.22 19/1

Bcaltk;, 18-35 re old. aonsaoklag.
actan blaclES aad caacasiaas.
Chicago, n. Bigldlr cont rolled
expeclaeatal coadltloas.
EBtHB: 1ICCBOLS; IILIIOIS; IOILTS;
CBIOBMITCI STtHOClBBOIS; TOHTI1!
CIG1BIC COBPCDIOS: HB1LTB BlUfES;
IlaillTIQI; BETIBOUSB; BBMBOIITSSi
f ICPWHTIOI HPOS9K: IFUIB 1EEIS
BBPIIETCE
Kcotostpuklt B.K.
Broaeai. S. B.
O'leUl. I.J.
1979
Joaraal of analytical
Twlcologr 3:225-234


-





1 1
                                                                                                                                                                                           Ni
                                                                                                                                                                                           UJ
                                                                                                                                                                                           o
Bagataalaac. antkrl-
1321-9*-*
C11-110
» 1*2. 8P -22 C. BP 2M.C C
nssiB
•Ml
Bc«atk










1

EIPOS»E BOBTE














IU1IIIC1L
BBTBOB
GC/BS











1

BOBBES
or cisss
8













iUGB
Pot d«t«ct«4-2.3 ag/hr












(•in
BEaB 1 eiltllL IlfOtBlTIOl
1
0.3 ag/kr 1 toapona frca aakaon origin. Bo
1 ether data lie glT«n
1 Crroavale aaapllaa taclnlqae.
|
1 taaltkr allltarv aad clTlllaa
1 *aplOT«as, U.S. lie Torce School of
1 l«raspacc B«Jlci««, ages 23-47 jr. 3
I >aok«ts.
I minis: CBIOITB»EO BIDIOCIBBOIS:
I cnoiiis oieinc COBMOIDS:
1 cnotoBEizziis: TUJOHIE COBPOOIDS;
1 I1IMB; alCCWLS; THIS; 1C01TS
1
VfcBC)
BEfEIEBCI
ceakla. J.p.
Caap, B.J.
Mlei. B.E.
1975
IrcklTcs of
EaTlroaaeatal HeaUk
30 (2J; 290-295




1
1

-------
fapataalene, MtkTl-
I3J«-»«-»
C11-114
It t«2, H» -22 C. IP 2M.6 C
                                                                                     (CORIiniO)
txssvi
»302
Btwtk












IHOSOB BOOT1














alalTTXCU
HBT8O9
0C-IS













miBR
OF CISXS
5* (317
•Baplas)












BITCI
lot : ncoBois; IU.HOIS; UHLTS;
CB10BIHTED BTDBOC1HBOIS; TOUTILZ
cteinc COIICDIDS: nuia BIIIBCS;
11BH»TIOI: ERIBOIISli BBIJEOimS;
FOftlUTIOt llfOSBIB: HHB1I 1B11S
txntxtcs
Krotoszjuki, g.K.
Brueav, G.I.
0'*eUl, B.J.
1»T»
Jotimal ot kntlftlcal
loilcolo^T 3:225-23*








llelnl
1«*0-02-0
II
Itl 5*.71.  If 1«S5 C. BP 2*31 C, re 10 •• ig at 2090 C,  100  mm Sj at  23TO C
Tissue i nposmi SOVIE
i
1303
(loot.
pl««a

• 30»
tlood.


•305
Blood.
pl*s»



XtbaUttai




iuimcit
IBTBOD


US


us

IOBBEB |
OF CISBS


«} 1
b) 1


6

1U6E


a) 3.0-4.0 «g/l
b) 2.5-9.5 as« caoc«r in practical
tipomc* cltMtlois. the a««4 {or
dos« r*fl«tratiOB i* capitalized.
ICIIkT; CIBCHOBIS; BLOOD rllSll;
DIXIE: tiBasxsxu. neitn-. nrm:
cnomi; a MILS; ncxn,; citciKGti;
IlDISTtlll UMSFHXEES: IIBDSTIIES:
cccopinoin >»»DS: IBOPHSBS
at Barker axpo*ed to last of
Imolubla 11 coapouls. Blniial
dlirail variatios
b) lorkat eipoMd to a«to«clt of
tclmbl* (i silt*, eradnal rise aa
4ay pro^ccsKl
Sellers i» roastlag-im-altiag SB a
electrolTttc tooactceats In lornr.
•mis: iicuH: •OBI«; iicflsriiu,
ITBOSP9BBBS; OCCOPiTIOHl BMIEOS;
neon msii: mitt
a) Erot«ln-pMcifit«tion aa*ple
preparation
t) acid-digeatioa saaple preparation
c) ProtelB-pnclpltatloa 
                                                                                                                                                                                          LO
-------
lickel
1MO-02-0
li
lt» 58.71, Ht 1«5S c.  BP 2637 c, TF 10 »  Bg  at  2090 C,  100 »  Bg at 2370 C
                                                                                    (COITIHOED)
KSSOS
• 306
Blood,
serna
•307
float,
•hole
•308
ireata
4309
Bltaeaii
• 310
nic
EIPOSIU son
Ingestion
lagestion
Xakalation


1 MI men.
IETHOD
IIS
us
PIK


TOBBSB
or c»szs
i
*
i


MIGI
i) 0.3-3.* ag/1
b) I.S-105.0 aa/1
a) 0.t-«.S ug/1
b) Z. 9-79.0 «g/l
lot gireg


aiti i GEEZBII IBPOBBMIOB
1
>) 1.60 * or - 0.93 I •) Baaeline »l««s
14/1 1 t) Wats, 2.5 hr after 5. « ig as
b| 33.9 » or - »3.9 I solfate
og/1 I
1 acalttr 21-32 rr old
j BO ««tal hTP«r*easlti*itr
1
| S«IOB!t; IDOLIS: BIOOO: BIOOO SEIUR;
| DII»: IICEEI
1-
a) 3.25 + or - 2.33 1 at Baseline Talus
09/1 | b) Peaks, 2. 5 hr after 5.« my aa
b) 2S.7 * or - 31. 5 1 tilfate
nq/1 (
1 Health t 21-3! re old
| 10 letal fc7p«r*e»ltlTitr
1 siBDZT; >DHITS: BLOOD: BLOOD siaaa:
| DIXIE; nCKEl
1
23. 1 ag 1 « 1 stapled at rat* of 1 1/ali, 2-10
| iln after tuning a arc vcldlag rods.
1 OniTersitj physics shop, Vlocida
1
1 flOIIIa: IBOLTS; BBZaTR; C1LCIOR;
I cnotiiK; cnonoi: COJPH; moi;
I iiJB: *»6»csB; ncrai; POIISSIBB:
I S01FIB; TITlllm; TIUHOa; H»C; 1IB
1 potiini(H: rtms; I»OSTXZJL
| KROSPHHES: TStCI ElBSEItS
1
t
1 nriev. Pcotl«» la risk analrsis of
I cancer i» It and Cr iidastry are
I prvsentvd* Tarioas coapoands ace
I cited vkieh eaase cancer in practical
| «lpos«ce aitnatioaa. The> need foe
I dose raglstration is e«ph«si»d.
1
1 ICBVIT: ClICHORtS; BLOOD PI1SR1;
t miisi iiDisniu Breinii SITIWJ
i cnomi; tmis; itcsn.; ciBcinsni
| TIIOSTtlil ITflOSPHEHES : IBCISTBISS;
1 eccipaTiovtt BaziiDS: «!OPi»sas
1
1 Berie*. 2* npresentatire
1 pr«-aialr«is treatamti are
I »•*«!» ted. la* f«asibilltT of a
1 aclistic, ac-vtsh poll c 7 for hair
1 amalyaia is cctliaed a>d serrortod.
1
1 tfTXCT: TPICI nmin: HUB;
1 losTBitii: msamsrr svtmes;
| IITUS; PBOTEIIS: COHP1B1TITE
1 ifiiuMiois; uvBnoa: miaviT;
| IBSniC: BilltJH: BBOHIfE; CIEBIOB;
1 cuciTjs; cBLOtnt: cnonvi; COBILT:
1 CCPTEB: enini: cisiiiina: eoti;
| lODMt; ISOB; LlintlDB; l»»t;
| HS1BSHS; B1K1BESE; IEBCOBT;
I tCHBVnOBs ITCKCl; PBOSPBOBOS;
| MtlSSIIH; BIBIDIBI: SSLZIHB;
1 mico*: sutti: somiB; STSomtm;
| SDIMl! TIB; TITIIIDS; TDISStZB;
I me: IUCCIIUB
1
BZFEEEBCX I
1
Ckristeasen, O.B.
Lag«ssot, V.
1)81
annals of Clinical aad
laboratory science
1ir«s119-125
Christeasen, O.B.
lmg»asoa, T.
H81
Innals af Cliaical aad
laboratory Science
1t{2»: 119-125
Ikselsson, K. B.
Desaedeleer, G.S.
Johausoi, T. B.
Bincftester, J.tt.
197S
Innals of Occupational
B»gi«ne 1»:J25-23S
varaeth, I.
1*80
Joaraal of Toricoloo;
and EnTironaiental
ff««lth «<5/*|: 12 W-1227
Chittleboroagb. S.
19 SO
Science of the Total
EDTicouent 10:53-75
                                                                                  (BtR
-------
flcxel
1*40-02-0
II
»tl 51.71. n 1*55 C. BP 2*37 C, Wt TO M Bg at 2090 C. 100 ll Kg at 2370 C

4311
Bale


4312
Orlne

4313
Brine



4314
Urine












Inhalation


HETBOD





US .



us


•OIBBB
OF C1SXS





al 35
bl 18
c} 68
d] 33
e) 32
fl 11



a) 1
b) 1


SIRS:





a} <10-90 og/1
bl <10-IO ag/1
c) 10-200 og/1
d) 20-130 ag/1
el 30-110 ag/1
f) 30-120 ag/1



al 13-54 ag/1
b) 25-47 ag/1


8 Ell





al 28 or - 10 ag/1
b] 3D or - 20 aoyl
c) 65 or - 42 aq/1
d| 52 or - 31 ng/1
e) 68 or - 31 19/1
fl 70 or - 30 e»/l



a} Bot given
b) lot given


enroll UTOBBITIOI
1 review of sorld literatare oa the
accvnlatim and bioconcentration of
(elected toxic trace setals in h1 and Cr industry are
presented. Tatioas conponnds are
cited «nlch cans* cancer in practical
exfossre situations. The need for
dose registration is •aphasized.
ICBS1T; CIBCIBOatS; BLOOD PItS»:
OIIIE: iieisniu HIGTHE: BCTICT-,
CEBosns: »TU,S; no; EL: CIBCIKHSEB;
IBOOSTBIll ITMSIBZBES; IIDOSTBIES:
CCCOflTIOSU BK1BDS; XEOPUSSS
a] contmls
c) Besearchers, ainiaal Bl exposure
c] Prodtct Sorters, soluble li
d) Caleiaers, »l dust exposoce
e) Extractors, exposed to dast and
f) tester plant, ll oosder and li
carbonyl ass expasare
Values corrected to l.t q/1
creatisiae. Data also for
ataospheric dost.
11 refiaery «orkers, 19-C4 yr old,
petro-cheslcal sorters as ccetrola.
IICKIU HITltS; UDOSTEIAL PHITS;
DUST; mm; UIITED KHGDOB;
cccn;»io*ai nzutos
a] Sorter exposed to dast of
insoluble Bi cosponnds* Peak at 10
at
t) sorker exposed to aerosols of
cclable (1 salts. Pea* at 11 as
Dlaraal variation in bats.
Ictksrs in coastina-sseltiia and
electrolytic departments in (orvay.
amis; IICKTL: KXCIT; tiiosTBiu
I1IOSV9BBZS: OCCIJPITIOHL BltlBDS;
IICCD F1ISR1; OBUE
1ERBEBCE
Jenkins. 0.*.
1»79
IP»-«00/4-79-049, 1»4
PP.


Borseth, T.
1*80
Joornal of Toxicology
and Environaental
Health 6 <5/6| : 12 19-1227

Horaan, L.S.
Eouge, P.J.C.
197*
annals of Occupational
Hygiene 22:311-317



BogetTeit, I.e.
Barton, B.T.
Indersen, I.
1980
Journal of Occupational
Bedlcine 22 (91 =597-600


(MM FIG11 •"' 	
-------
    Ilckcl
    1MO-C2-0
    II
    Itf 5*.71. IP t»3S C,  W  2«7  C, W  10  u  S*  at 2«0 C.  100 •• Hf «t 2370 C
                                                                                        (cortmrsD)
TISSII
«315
•rtaa
«316
OElM

EIKWiil tO«TE



MUniCU 	
since
us
us

* " cram —
or cists
is
*

1IK1
t.9-9.6 u«/l
_
*) 0.3-3.* WJ
b) 17.7-202.0 tg

m» '
*.*5 » or - 1.9 BO/I
a) 1.5* * or - 1.99
b| 69.56 t or - 59. «
••5

ctimi iiroiiHioi
Etctota-pnclpltaUoa saspl«
pctpacatlOB
Maltkr 29-«7 yt old*
•OIMT; IDBtIS; HOOD niSHl! OSII1:
CCBValtTlfC ZTIlnTlOIS; fllaSfflEHSR
inioDS; tiauniminoi; IIDUSTEIII
taissio»: ncni: BETIIS
•
tl m«r «.« B4 i> nlfato
nalUr 31-31 re aid
smii; IDDIB; BUM»: suxa iirra;
onti: ncm
B'smcs
Torjuuo. I.
Zackarlaaa, H.
cllalcal Chaalrtrj
2* (7) si 19*- 1202
-
CBElct«M«B, O.B.
t9*t
•aaals of Cllalcal aad
laboratorr sdaac*

  111-84-J
  CJ-BM
  M IJ8.25. BP -S3.7 C. M ISO.T C. TP 10 •• B9 it 3B.O C
nssot
1317
Irvatk












tinsras tofTf














•UtTTICIt
BIT BOB
OC-IS













imun
OF C1SJS
5« tJ»7
•aipl«s|












MMI
•at «iT«













IUI
O.J48 15T/1
s*«Mtric












eillUl IffOMHIOl
B«a«u»d »t 25 C ail 760 •• B licit*
C.0«* aii 1.J7 14/1

SMltbf. 18-35 yr old, »OB»olilBg>
•TtM blacks aid caicatlans.
Ckicifo. 11. Ilqldlr cg/l

GIIIUL nroiittiof
M«nr*4 at «Bd of working i»j, f«aa
ale Ionia 10-13 BIB.
laboratory aasistaats «orkla« clta
ocqlalc solrtBts.
CCCWII101H utitm GSMatt:
»Ml«; BU>01t CatCIBoen
timnct
l«1m«rt, 6.
latacBBtloaal arcnlTos
of OccapatiOBal aaA
BBTltOBMBtal IMaltfc
• 3-.1W-150
                                                                                      (tin
-------
          i en
NBZ*M, 1.2-4i«Url- & CI)
ct-no
II IOC. 1C, IF -IS C. « 1«« C, TV 10 •• Ig tt 32. t C
                                                                                   (CORIIDIO)
tissn

Bnatk










•330
BriB*














mosaic Bons












tBaUaU..














luimcu
BBTBOD
ac-is










•nc














nmt
or cms
5* on
«BDl«)










Bt *
b| «
O 2












_
BUM

Bat giT«










•) Bot git«B
b) lot gins
e) 0-0.1* ag/Bl













Bill

1.0 BO/1
saoBatclc










a) 0.0037 * or -
0.0007 i»»l/kg CM ot
toM)
b] Trie*
Ct lot ftTM











BCBIUI UTOBBHIOB

e Bg
lovK aad «PP*r o»»-Sliaa Halt* 0.36
aa* 2.8 Bg/1

BBBltM. 1«-35 TT DU, BOBIBOxiBg,
irtai tlacfeB aad caacadaaa.
Caicago, 11. Bigifly coatrollvd
«p«rli«BtBl coadltloB*.
IBEUI: IICCBOL3; IIUKHS; IDOLTS-,
CBLCBInlBB EnBOCaBBOBSi TOUT 115
CtGliTC COBPOUtBSj BUUB ItUIOS;
IIBlUTIOBl BXTMOLISa; iniBDimSl
'
a) o-Tolaic actd gl««BcoBl4«
(aatabol.lt*), 2B kr «zcr«tiw att*r
0.3*1 BBol/>g o-zTl«lw, oral. Paak
la 3-< be
E) o-lolalc add glvCQCoaida, att*v 3
ti «xp«*«x* to 13* ppB tr-irlcaa
c( p-BBtkn*ipB«rle Bell
(BBtBbollt*), attac oecnpttloBal
«*POCBC« tO 17l«.B*. B«tiBBt«d CTOB
9Kapa
telBBtOTT** aaaa »a« S3 ft total).
nl »* rr (vapor). f»lBt«r« in
aaippatldiBg rard, a«aa ag* 32 jr.
HUB: iRIBGUTIS: tllS;
eccwHioBii iiittDS; wminoB
tlPOSOU: 1K1TL HBRlLSj P1IB1S;
1IIUUIOB
mctnci

KrotoniBBkl, B.K.
Braaaa, e.g.
O'Belll, B.J.
1979
Joaraal of laalytlcal
Toiioologr 3:225-23-*






Ogata, B.
TaBazakl, T.
Sagikara. I.
SblBBla, T.

1980
lataraational areklra
of OccipatloBal aa«
EBTiroiaeBtal Boaltk
*6: 127-139







                                                                                                                                                                                       U)
                                                                                                                                                                                       Ul
 cctaa«
  111-CS-4
 CI-BU
  tl  1U.21. B» 5t.« C, BV 125.B C,  TV 10 •• B« at  19.2 C
imti
«121
Bt«ath











EttOSOB lOOt I












taunicu.
IB1BU1)
OC-S3











BtBlZB
oi cats
5* (3B7
•»»!••)











laKB
lot glit*











Bill
0.296 ag/1
e*o««tcle



'







cBimi iipOBamaB
. _
8«anna at M C ul T60 aa Bg
21. K oecnme*
loaac ud IPPBC oa*-Slgaa Haiti
D.079 *>d 1. 10 ag/1

Kaltar, 1S-35 re old, noBtBoklag,
»tu blaeka aad caaeailan*.
Ckleaqo, 11. ttgiAIr ooBtnlKl
•*P«rlMBtal oaBditleai.
EBEITB; 1LCOK>1S: ItlllOIS: 1DOMS:
CnCKIaTBD BTOtOCIBWISi TOIaTIU
cHinc coBPtmns; IULTB aiuics-.
IIBUITIOV; BKIBOIISI; mUOlRBS;
tatmma* tttonn; »BU MEIS
_.-._,
IfcfBBIlCE
Kcotonfa*ki, B.I.
axBaaa*, 6.8.
C'Belll, E.4.
1979
Jooraal of taalTtieal
Toxioologr 3:225-23*







-------
  Cctuolc acid,  peatadecafliioio-, aeaonUe salt
  3(25-26-1
  Cf-R-T15-02.B3-I
  BS  430.98
1ISSOB
4322
Urine









t

EIPOSVU BOOTE













• U1TTIC1L
HETBOD
ec












BOBBES
OF CISBS
1












SIEGE
a) lot applicable
b) lot applicable
c) lot applicable










Hill
a) 387 eg/24 he
b) ITS 19/2* hr
c) 80 ug/24 hr










GSIIBll IITOIUTIOI
•1 1 »k
b| 3 10
c) 14 M
Interval follo«ia
-------
                CI)
               . «-(t-MtkTl«tkrl|-  f» CI)



II 150.22, Bf 2« C, BF 2«» C, T* t »  Ig  at  7«.2  C
1ISSII
•125
Srtatk












citoswv Bone














uumcu
GC-BS













•DBBIt
or CISTS
5* (317
•aaplfs)












UIG1
lot giT«













till
._
0.2«1 »9/l
GaoMtric












Gimal IITOIBMIOt
l«a»r«4 at 25 C aid 7(0 n 89
It. S* oecwraBO*
lewt »»1 vppn «a%- slga*, lliiti
0.03* aad l.ti Bg/l

••alt-VTi 1%— 3S yr old* BOB8BOkiii9r
attn blacks ud eaaeaslau.
Ckicaqe. II. tloiair coBtrvjUad
*icaria«Btal eaBditiont.
E1I1TB; ttCCBOI.!; IlXIfOIS; IDBITS;
cnoiinTti miocaiBois: TOIITILI
C1GMIC CO8PCOID3; HH1TB B1I1IDS;
IIBltkTICI: SIT1KJIIS*; BETIBOHTBS;
ropouTiot uposm: onii tins
unmci i

Braiaaa. S.a!
O'Mill, 1.3.

Jonraal of IMljtlcil
7oxicolO9T 3:225-234








I-Di«XtM  It CI)
1.«-Iioxtce  (» CI)
1J3-»1-1
C«-I«-02
11 €1.10.  » 11.80 C. IP  191.1  C.  T; »0 •• 19 *t 25.2 C
tiss«
Bnatk

Bnatk


titosui JCHTI





BMBCD
ac/as

ac-gs


or cisis

- - -
5* on
sMplatf)


I1IE1
tot 4*tactad-0.a| ag/br

lot 9lwu


Jill
0.05 «g/kr

0.253 ng/1


eiinii iiratnnoi
CcifovBi r«laua to aonal
Mtakollca. 10 etkar tetail* gl»»
CiTogoic aaipliBg tackolgB*.
laaltkr illitarr mi ei*illai
aaplor««a, o.s. ale Foce* School of
Mraapaea BcdielB*. ag«* 23-*7 yr. 3
nolacs.
IlltZISS; CHOtlllTBD RDBOCHBOIS:
cnmitt fiKjnc COBMIKDS:
ciLCMBtnnis: nnotiij COBSOHIDS:
EIUTI; 1ICCROIS; TB1U: IDCITS
!«aanat at 2S C »m« 7«O ma 89
21. B< occnnne*
lame »nd upper aa*-SiqM lliits
0.0«7 aa.1 1.37 Bq/l
BaalthT* 1B-3S TI olt, BOBiMkUg,
CUcaqo, 11. tlgldlr coatioll«4
«ip«cta«Btal coiditiog*.
{111*9; ilCOBOiS; IILIKIS; 1D01TS:
CIIOIIUTtD RBMCtlBOIS: T01ITHI
tisnic coitcnDS; nun BIZUIIS;
IIBlllTTCI; aitlBOlISB; attlBOimS;
fopntTioi IDOSVR: otan mis
HTXRffTCE
Coakte, J.I.
Caap, B.a.
**lea. B.I.
1»7S
lreklT«0 of
ZavlroBBCBtal Rcaltk
30(21 :2«0-2«5

CtotonjBskl, B.X.
D'lallli *••>'.
•\m
Joarasl of taalrtlcal
toxleologT 3:225-23*


                                                                                                                                                                                              OJ
-------
                      (I CI)
   Cyclokoxcaa, 1-B«thyl-4-(1-Mtkyl*thmyl)- (9 CI)

   C10-B16
   If 134.23. K 174.6 C. TP 1 u Bg at 14.0 C
1I3SOB
432»
Bxoatk











BXNsni toni













1I1LTTICU
HBTHOD
OC-IS












tana
or CUES
54 (387
•aipics)











S1IGS
lot givra












BUI
2.9 ag/i
6«OMtrle











6SIZB1L ICFOBUTIOI
Ma«U*4 «t 25 C »d 760 aa Bg
94.5* ocetrrwc*
lowtr aal ippar o>*-SiqM limits 1.07
•>4 7.9 B9/1

Icilthr, 18-35 TT oil. aoBSMkiag.
irtan blacka ud CMCuicu.
Ckiecfo, n. llgUlr eoBtroll«d
«sp«rlimttl coiditlOB*.
Ellin: ILCOK>LS: IILIKISS IDIHTS:
CtlOBIUTIV IIDBOC1BBOBS: TOI1THI
cieinc coircons: HMITH usues;
IHItlTIOI; 8R1B01ISI; BBTUO1RBS:
loraimoi nnsoii: HIBM tuts
nnBEBCB
KZOtOSTIBSki, 3.K.
Br«B«fta« G.H.
C'Klll, B.J.
1979
Joarial of faulytleal
Toxlcolegi 3:225-234


'




   -»k««Tl*»«Uula«  C CI)
    4-SnMMdlailM  |9 CI)
   106-£0-3
  C6-M-I2
  II 108.7 C, H 1W C. BP 267 C
IISCTB
4329
orlM













BXPOS0B BORI














.
1U1RIC11
•BTBOO















IV1BBB
OF CUBS















11KB















mi















6EIEBI1 IirOIUTXOB
l«Ti«w. Xocil ui *TSt«iic «f fccts
c«l«tli9 to kair IT* fonalatioi.
l*4t«dl««t testa, til •xp«ti«ac«a In
IIB and aiiials.

Cmtaet 4«riatitis it uan. tktir
tfoiMS, dcatists or etlwra in
ccataet vltk tcecatly 3l*& hate.
Iaa«dlat« krp*rma*ltlYlty
lirticacia) ivpoctei.
ItOHSi DBBIKITISi IBOPI1SHS; BSI««;
II TITBO II1ITSIS; II TITO 1111 ISIS;
IZTIBV; DIBS; CUCIIOSEB: COSBITICS;
SIIBTIC BFrBCTS; nUTI I1Z1B9S;
IIT1BOIISR: IR1BOLITBS
BBFBBBICB
larziUll, r.t.
6re«a, S.
•alback. B.I.
197*
Jovraal of
BaviroBBoatal Pathology
and Toxicology
1! 509-530







                                                                                                                                                                                           U)
                                                                                                                                                                                           oo
F-Tolulfakyte (« CX)
Hnxalookyl*, 4-Mtkyl- (9 CI)
104-B7-0
Ct-»8-o
(I 120.16. BP 204-205 C
IISSOI
•330
Btaatk











t
I
BXPOSDIB BOnX















iiumcu
HBTBOD
OC-BS












1
t
BOIBZB
OF C1SBS
-
54 (3*7
M«pl«S)











1
»
111GB
lot glT«n













I
BB1I
J.3 »g/l
SeoMtrie












1
6IIIB1L IirOBUTIOl
laasvrod at 25 C a*4 760 •• Bg
!.7f occirrvac*
Ic«r aad ipp*r OM-Sigaa. llaita 0.7
aa4 15.4 ig/1

l«altkT. 18-35 yc oH, soaaaokloq.
•ttaa blacks aid caacaalaaa.
Chicago. XI. ligidly controlled
aip«rla«atal coaaitloM.
(1BRI: HCOB01S; lUXKIS; UHIIS;
CnOlXHTIB IIDBOC1BBOIS: TOtlTILI
CIGWIC coBPcnDS: IUITH iituns;
mtllTIQl; IBTltOLISfl; ItlUOLTTES;
I (O?«U1XO« CnoSVR; «BB» HEIS
1
SZRMICB
Krotoaxyuki. S.It.
Braaoaa. 6.B.
O'H.ill, B.J.
1979
Joaraal of analytical
Toxicology 3:225-234









-------
      «»a  («  co
IUMM,  1.4-41actftrl-  19 CI)
10«-42-3
CB-B10
•I 10C.1t. «f 13-1* C, n 137-138 C, »* 10 II B9 at 27.3 C
TISSUE

•331
IlaoS





4332
Cnata










4333
traata












sitosrac sons

lakalatton
































11U.TTICU,
tames
oc






sc/is











SC-BS













mnxi
or CUBS
*






*











5* (3*7
saapl**]












11161

1.04-1. (9 tg/i






lot 4«t*ct«a-0.»03 ig/hr











lot 9l**a













m*

1.3075 »o/l






0.000* oaAt










.. -
3.1 ng/1
SMMtcic












6IBHU, nromixoB

It p»r« » Mta, Ma*u«d «t od of
forking 4a|. B«u *lr !«•!< 5«-6«
**•-

CCCIMTIOIII BI111DS; SB1B1II;
HULTS; BLOOt; CUCItOUII

Ce«poi«l ftoi ukion oriqla. >o
«th*r 4«t«ll« qlnc
Ciragvmie «ipliiq tcehxlqo*.

Bmltkr illltacT ud clTilUs
«iplor««9, U.S. lit Force school of
l«nsp*c« ••fllciM. «?«s 23-**7 jr. 3
iiolwn.
tlllltfS; CBIC1HKIB RDIOCUBO1S:
cBioint oisinc coiMms;
CBiciosmnts; nooitn conoviDS;
HiiTB; iicoBois: THIS; icnvs
I«*>drtl «t 2S C «*a 7SO •• Bg
9t.7< oceoTTcne*
lenr M4 vfpct OM-slqu llilti 1.2
»4 7.4 B9/1

BtaltkT, 1S-35 yr aU, noacMfclng.
ntu bl«ck> Mi nietslu*.
Ciiragot 11. liqidlT ca»ttoll*A
«lp«tlwit«l co*tttio»s.
Itlltl; HCOBOlSi IIIIIOI3; lOOltS;
tBtotiiiTiB iraiociiwis: foums
aiamc coRfcnDS: HILTB IUUDS;
HBiittia*; reritouss; IBTUOLIRS;
icmnTiof inosiu: D»B»I usts
itrisnci

tnq*»r, J.
I«Ia«ct, 6.
H7»
Interaction*! icchlTca
of Occvpctlonal ana
initoaMBtal B«*ltk
•3:154-150
CoukU, J.P.
Ca«p« B.J.
Mich. B.I.
1»7S
liefeln* of
fariroBMntal B««ltb
30 (2): 2*0-295





KrotoczfMki, B.K.
Braa«a*« 6. B.
O'Mlll. B.J.
tm
lonnal of laalytleal
Toxicology 3:225-23*








                                                                                                                                                                                            to
  1440-05-3
  I«
  It! M«.4.  II IMS C,  « 3167  C.  n 1 aa Bg at 1*70 C.  10 aa Bo at 2290 C
IISSOB
«33*
lAlBOB*










IHOSDtl WJBTl












HllRXClt
BETBOD
US











10B1S1
or casts
10











(1KB
- -
Bat gti«a









.
{•in
SEtl
O.« pnb









.
rteo
eimti nroiBMiOB
.
loa k«7«l«« nciteat*

UtopiUa, 12-79 rr olds.

ntus; pnumB: PIILIDIOII: isu>s
TOfDllTIOB BimSOIB; OCCONTIOBU
Bixites: cunosBii: iirropsr«s;
HOOD; 1IDKIS: SniBB; Bill; D1I1B:
HISS; «VSCltS; UIMSB TISSUI;
HTM! COBtlUNfB EIliH«IOlS: BS<
onsiT: calm; BIS»B: IOTOBOTITB

•EtEtXBCB
Joha*oa. O.E.
Fc«*oct, J.J.
T111«T. l.t.
Caaaaa. 9.1.
(OMafela. J.B.
197C
B*»-«0«/1-7«-019. 235
PP-




-------
tainau*
7MO-05-3
n
Itl 106.*. at 1S55 C, If 3167 C, TP 1  aa Bg at 1*70 C,  10 M Bg at 2240  C
                                                                                (comnsoi
IXSStll
1335
Hood
•336
lilr
•337
XldMT
•33*
1 1 MI
xxtoson tooi

1
1
1
1



t
1

t immcu
EETIOD
US
us
US
us
•oasis
or CUES
2»3
2*3

10
met
a) lot git«n
b) lot giT«
c) lot si no
lot giro
lot sires
'ot givaa
SMI I cEBtiu iiroBBinoB i IETESXICS
1 1
1 t
i) <0,9 19/1*0 «1 | i) lorn ligclaa aad laacastar | Jekaao*. O.K.
b) -»•
1 «>fl* 1 Cuaia, D.I.
1 c) Iue»t«r rtaid«*ts. cotjwsita | Hos«afeM, J.I.
I ««npl« | t»7S
t I CTI-«00/1-7«-OI9, 235
1 CiltforilM* liTiig do»«ii4 fro* a I pp.
1  tk« kigfc I
I 4<>ert rwjlei of lue**t«r. »g« 1
1 gtonps: 1-1f. 17-34, 35 or mor« re. |
1 «OV «hit«, »0« aoa-ihlta t* lo> I
1 >•«•!«. 80* «klt«, 20* »oi-«hit« l» [
\ I«eist«r. |
1 |
1 inus: pinnras; ruium: tin; t
t iefOLKtiai KPOSOM: occopuiofit i
1 nxiEtS; ctiirotnt; itrrofsizs: i
1 HOOD; (IBHTS: SM.IEI; uii- raill; 1
1 muss: mscust ivttost Tissra; i
1 iirra: CORPIMTIR tniUTioiSt »s» i
1 JESSiT; CHIN: mm: UTOMTITI i
i - - - i
1 	 ! 	
<0.02 aaV9 1 lo* MaolM «nd Laacutn ro«ia«nt« 1 Jofcnson, g.i.
1 | Pt«TOJt, S.J.
1 callMntai* llrlaa dovnled Iroa a I tilled. J-B.
t ft««»«T In Ic« lag* In or in tk* kiafc I Caaaiia, O.K.
1 d«Mrt caglci of laactttcc. lg« | BoMafcU, J.B.
1 atoips: 1-16. 17-3». 35 at *oc« T*. 1 «*T«
1 tot chit*, *0f 90t-«kita la tos t Kl-600/1-76-019. 23S
1 Jn^«l««. to* vklt*, 20< aoB-vklto ia I pp.
1 laacastvc. |
1 »TRS; PLITHUB; PHUDIOB; 1EID; 1
1 ICPtUlTIOR HPOSIHIt; OCCOP1TIOIU. 1
1 IlliS IS; CllITOMIl: tVTOPSIB; 1
i ztooo: KIOKIS: spun; HIIJ; nun; i
1 tO«SS; !I9SCUS: 40IPOS! TISSOI: I
t iifEt; coipitinn miMTiois; n* t
1 JttSBT; C1I1E1: IIIIK; 10TOBOTITI |
1 1
t 1
*7 ppt f toa la?al«a r«aiil«>ta I joknsoa, P.I.
1 1 Prorost, ».J.
1 latopsUs, 1Z-7« rr old». | TUl«rr, j.».
t 1 C«a««n, D.r.
I HT»is; PIIIIIIB; PUIIVIOI: LBID: i goa*tf«u, J.B.
I Topnmoi EXPOSOIE; OCCO?ITID»M. i 117*
i Binars; curromi; IBTOPSIIS: i iM-«oo/i-7t-oi«, 235
1 HOOD; KiDBtis; SPIES*: nit: ttn»; i pp.
t loies; SOSCKS: taiposi tissast I
1 IDtP.; C01PIHT1TS tfllVtTIOfS; RV I
1 JHsn: ci»u: mites IOTOIOTITI i
i i
t ppt | lac la«al*> resldeats I Johasoa. D.I.
1 t Iftnst, i.j.
I Ittopsios. 12-7* rr olds. I llllwr. J.B.
1 1 caa»n, D.I.
1 fltlLS: PIITITOB; puikBiai; ttiv: I BosaafaU, J.B.
I lOPOHflOI IXPOSVIE; OCCnPITIOBJL I 1*76
i B im«; CU.IIOMII: amopstiss i Kp«-sao/i-7«-oi», 235
1 HOOP; KIBIIIS; SPIMI; Mil; milt; | pp.
I ines; nvscits: asipos: Tissue- i
i tun: coRpimxn mmiTiois; n« i
t JHSlt; CHItt; ft* IK; 13VMOTITE I
1 1
(Kit PIGE| . .
                                                                                                                                                                            N>
                                                                                                                                                                            .p-
                                                                                                                                                                            o
-------
falladi*!
7MO-05-J
ft
M •»«.«.  n 1555 C, SP J1S7 C, fp 1 •• Hg at 1»tt C.  10 » Eg at 2290 C
                                                                                     (COBTMBED)
nssoi
4339
LHfifl
aaWinj









wo










*3«1










*3«2
Oriaa

















iiposon BOOH



















































tinmen
•ETBOD
US










US










us










us

















BWBEB
OF C1SES
10










10










10










a| 203
b) S8

















I1IGE
lot glT*n










Mot girea









- —
lot gitaa










a) Bot glfea
b) 0.10-2.61 ag/1

















Mil
<3.3 ppb










<2.2 ppb





















a) <0.3 ag/1
bl 1.07 » or - 1.68
ag/1
















««ni i»o»»i<»
lea lagelea caatdcata

latopaim. 12-79 yc oils.

BFIILS; PHIIBOB; MtllDIOB; 1EU>;
PCPOHTIOI 1IPOSHBB: OCCDP1TIOHL
tazutfiS; ciiirtnni: IOTOPSIES:
P.1009; KIDIII3; SPMEl: Ball; null;
miss: mjsctis; iinposi TISSDI:
iiTij; coHPaunrr EniOHiois; IEV
JEBSET; Clllta; BtlHG; moBOTITE
loa lBg*l*a xaaldcata

lotopaias. 12-7» TT olds.

EIT1IS; PlaTIBDB; P1LHDIOS; LIU:
corniTTOi EjposDEB: occur ITIOI it.
« ins is-, cinpoBinj imotsizs;
BIOOD; nmns: SPIEEI; B»B: OEIIE;
UIGS; BOSCIB: 101 POSE TISSUE;
IIVEB; COKPltaTITC ETtLDITIOBS; IER
JtBSEI; CUata; BIBIB6; inoBOIITE
lea laaalva naideata

tntopalea, 12-79 TT olds.

enus; PI1TIBUH; PUIIIIDB; LBaD;
topoiiuoi txposrae; OCCOPITIOBU
aiziBDS; ctiiroBBia: ITTTOPSIES;
BIOOD; KIOIZTS; SP1ECT: Ball; UBIIE;
10IGSJ 10SC1ZS: 101 POSE TISSOE;
IITBI; COnallTITE CTHDaTIOBS; BIV
JIBSEI; Clllla; BIBI1S; 1DIOBOTITE
at los lagelaa aid Laa caster
c«aid«Bta
t) OccanatloBallT cxpOHd. Bighast
»«!»« i» stoiarocm »oiX«

CalifocBlaaa litiag dovnvlid £ loa a
fracnar la lea lag«l«s or IB the high
d»«rt reglaa of laacaster. iga
gtospa: 1-16, 17-3*. 35 01 aoi« 
-------
   t«ntaa«. 2-ntkyl-
   1C7-83-S
   C«-B1»
   n 86. 18. ft -153.47 C.  It  5«-«fl C. It  109 •• "« «t •* 1 C
IIS SOI
«3«3

MPOSIIS BOOTI
iBkalatioB

t»i. mot
HXTBOD
ec/BS

loam
or cuss
10

I DOS
0.5-5.1 19/1

Silt
2.5 » or - 1.6 sg/1

siiini IITOSUTIOI
is 2-awtkyl-2-p*ataBol (••tabollte)
Icrters In ska* factory IB Italy
BBiiE; BTDtocauois: inuoims;
mil: iiBDsniii ITBOSPHSBIS:
IlIDSniU BTGIBK; *XB POllUTIOl;
OCCDMTIOiai DXSI1SSS
nrzszBcx
P«rb«lliBl, 1.
P*T«BV I.
1980
Toileology and Ippliai
Phar.acology 53:229-229
        «. 2.2,*-trlMtkyl-
   ••O-M-1
   CI-Btl
   II 1U.2. tt 99.2 C.  TP *O.C •• •« at 21 C
IISSOI
«3««
Br«ath












Biposni toni














IMlItlCll
•moo
GO IS













IUHBIB
or CISES
S* (387
saBplra)












I1ISI
Bot gir«













Mil
0.60* Bg/1
G«OMtrie












GIKIlt IirolBITIOB
§«aior»a at 25 C aid 7*0 •• 89
29. ?t occurrence
loocc aai 
-------
CC-I1*
•i tf.n, BF 63.3 c, TF in mm 09 it lo.s c
IISSVI
•3*6
DrlM

IHOStB BORB
Dvraal

1*UITICII
•SWOB
«C/BS

I lOHEt
or cuss
10

I1I6E
a. 1-1.1 ig/i
.
Bill
0.5 » or - 0.» mq/l

enziii HFOI-UTIOI
is 3-*ctkTl-2-P«tamol (»talx>liU)
Oat* also «s Eolnatx is factory ail
1«rk*t» 1» aho* factor} in Italy
inn; nnocmais; nruoutis:
nui; iiogsniu IMOSFRIIS;
IKOSTtllt neiltti III POI1BTIOT;
CCCVFKIOIll IISIU13
-
•EFIUICI
F«rb«Ul*l. 1.
iteo
Toilcologj aid Ippllad
PharaacolojT 53:220-229
{•ctuelc
3JJ55-3J-I
11SS11
»3»7
imtk












TIJOSOSI 1ORI














uunicii
HRBOD
SC-BS













man
or cuts
5« C3*7
OMflW)












I1H> 1
1
1
lot gir«B













Sill
0.062 ig/1
G«oa«tcic












eilttll IlFOttlTICl
Mint*! «t 25 C »a 7*0 » Bp«r oM-sifn li*its
0.032 «l4 0.114 »V1

l«»ltfcT. 1«-3S Tt olfl, noABMUiig,
«rt»» blicki «J Caucasians.
C41cai]o. 11. lifillr coattoU»a
• ipvrtmtal oaoditlaai.
HIITB-. 1ICCBOLS: IUIIOIS; 1DV1TS;
tBLOHMIID ngBOCanOIS; T011TILI
tlSlKC COBFCraiS; 1ULTB B1IIBDS;
iiiumci; BEIIBOIISB: airiBoirris:
raFOiiTioi xiFosnE; ami istis
imsracB
KCOtOSXfMki. 8.X.
BTUMV. G.l.
O'Weill. fl.J.
1««
Joaraal -of Inalrtical
toiicoloqi 3:225-23*








 laatil alcatel  (» CD
 1-lwt»ol t« CI|
 7V»1-0
 C5-I12-0
 ii w.i. w -T* c. BF m.e c.  IF  i » B« at u.t c.  10 u
                                                            it
                                                                 .S c
1ISSHI t
1
I
*3«f
Bnatk











BXFOSIB KX1I
-













uuniciL
action
Be/us








"



BUBBEl
OF C15XS
8












Rim
•at 4«t«ct«a-fl.6D ag/kr











(HIT
«E»»
0.13 V9/1T











	
F1GE)
SI»»t TIFOtBlTIOl
Ce*Fon4 r«l«t«fl to aonal
i«t«bolisa. lo otk«r detain qlnt
CTT»9«aic saapliaq tccbnlgt*-

B««ltkT illltarr ail ciriliai
«iplore«». 0.3. lit Tare* Sckool of
l«rospae« a, a4«s 23-«7 jr. 3
saokera.
IfllEfBS; CBlCBIlltIO ITDtCCHBOIS;
CBtonn 03S1HC coBFoms:
tiioioBnzim; nuoBii! COBPODIDS;
tBtlTf: ItCCBOU; 1EIIS; 1BBIIS

nnanci
COBil*. J.P.
C»«pr B.J.
Mick, B.I.
1»75
irekiraa at
FBTironacnttl H«»ltk
30(2):2<0-2*5






-------
        alcohcl (8 CD
 1-Pentaaol (9 CI)
 7 IT* 1-0
 C5-B12-0
 n 88.1, IIP -79 C. It 137.8 C.  TP 1 •• Eg at 13.6 C.  10 •• Eg at *».9 C
                                                                                      (COEIXI9ED)
TISSUE
«3»»
Breath













ntosDBX BomB















IBalRICll
BET BOD
GOBS














BOB EBB
OF C1SES
5* (387
saaplas)













B1B6E
lot given














Bill
0.505 ng/1
Geometric













GBEBB1I, IiroBBlTIOE
teetered at 25 C aid 7«0 •• Eg
21.7* occurrence
IOMC and apper oae-Sigaa Halts
0.128 aid 1.99 mq/1

Btalthy, 18-35 yr old, nonsaokiag.
gttaa blacks aid ca«ea«tai».
Chicago, n. Kigiair controllaj
•ipcriMatal coalitions.
EHITfl; ItCCBOLS; IllIIOIS; IDD1TS;
enoiiMTte imociiMis; TOUTHS
CIS1IIC COBPCUIDS; BJilTB BltlRBS;
HBIL1TIOI: BIT1BOLISI; BEtlBOLITBS;
poroiiTioi ziposaiB: OBBIB u»s

SBFBBBICB
Krotossjaaki, B.K.
Braacao, G.B.
O'Mill, R.J.
H7»
Journal of inalftical
Toxicology 3:225-23*








1
Ihtaol
108-9S-2
CC-B6-0
II 9«.It. HI W.85 C,  BP 182 C.  T? 1 aa tg at »0.1 C
Tissue

• 350
OCiM








• 351
DtlM

















BIPOSOBE BOOH

D«raal









Inoestioa


















Jllimcil
HRBOD
9C









OC


















ins Bra
or cases
a) 15
b) *0








a) 39
b) 119

















BUSS

a) 1.0-5.0 aq/q
cr«atinin«
b) 5.2-13.2 ag/g
er«atiaia«






a) lot gira
b) lot gi*ea

















HUB | eilllll nrOBIATIOB
1
a) lot giTen | a) Coitrcls
b) lot giv«B 1 b) Vorkars espos«d to chloropheaols
1
1 Icrkats in herbicide laaufaetaring
I plaats.
1
| BfBBICIDES** UDVSTKZ&L PLANTS!
1 OCCOPlTIOItl B1ZH9S: PISTICID1S:
I fOPOHTIO» HPOSISE; BS1SU1BEEIT
| BITBODS; CBICBIIB OB61IIC COBPODBDS;
I tttlOlS; CIB1S1; 7BIBE
1
a) 11.97 » or - 11.60 I •) Besldaats lliinq 120-310 a fcoa
•9/1 | still site
b) 11.56 « or - 10.86 | b) Coatcola
KJ/I 1 B«asar«d « mo after Incident
1 >0.1 ag/1 fenad at least oaee in veil
1 «ater of study group
1
1 Bcsideats of East Tror, II. site of
I accldeatal rail car spill of 37,900
1 1, 197«.
1
1 Ciarrhea. aovth sores, dark vriae.
1 taraiig loath, reported by
1 significantly eore persons In study
1 groap than ia controls
1
I BISCOBSIl; OIXBZ: CCBPmTIK
1 BULUITIOIS; PBBBOLS; DBIHIB6 1»EB;
1 6BOn9 »T(B POlLtJTIOH; BETlBOinSS
BZIEIEBCB

Tan Koogaalen, p.B.
Klein, 1.1.
Draaaond. I.
19«0
International IrchiTOS
of Occapatioaal and
•5:5>«2



Baker, E.I.
landrigaa, P.J.
Bertozzi, p. I.
Field, P.B.
Pasteyns, B.J.
Skinner, B.C.
1978
Archives of
EBTiroaaeBtal Health
33 (2) : i9-«









-------
 fttmel,  c-ckJoro-  ft CD
 rkeiol. 3-ckloro-  (9 CI)
 tOf-U-0
C6-BS-C1-0
II 121.58. » J3.S C.  BP 21« C
IlSStff
• 152
tlaoi.
viols

















WWSflS 80 Ott



















ilUTTIClI
HETBOD
BMC


















inatra
Of CISSS
a) 35
b| U


















BliGE
*] 1-i« »«/g
»l 32 -U D4/g


















BUI
a) 19 ag/g
li| SI »»/g

















[
GIIIUL IIPOSU-IOI
«| loia Canal rullmt*. *« (1C)
FCiltlra
l| tolwtMca. 1st (2) positive
Huge *n
-------
  fhnol, p-ehloro- (8 ci)
  Iheaol. *-cbloro- t» ci)
  106-M-9
  C«-«5-Cl-0
  (I 12S.S6. H «3.2-«3.T C. SP 220 C
tissos
«33«
BlOOl.
• bole





















JIPOS01E BOOM
























imnxcii
RTBOD
HP 1C























IB8BSB
or CASES
a) 3«
b) 13






















flies
a) 1-90 a«/g
b) lot applicable






















mi
a) 29 «o/g
b) 2 a«/g






















GiiniL nroiRHioB
a) love Canal residents. 29* (10)
positive
b| Tolante«r>. 8* (1) positive
laiq* aal aeaa of positive aaaples.
Tilaes corcected for tecofety
Closelr satched, sisaltaneois control
sasples >ere not pcorlded foe
•aalTsis aloig «itk those ftoa the 36
IOT» caaal acea r«siA«ata sa«pl«d.
lacklnq seaalavfal control or
litecatace data relative to the
siwiflcance of the lo» reailaea
toned ia the field saaples analfxea.
ao tefialte conclusions can be dra»n
froa the resolts reported.
lesldeats of lev Tork. Controls,
esplovees of the SaTlroaseatal
frotection loeacy aad oaiTcraltj
atadeats. lorth Carolina.
II« TOIK; 10ITR CUOUM; BLOOD;
Bitsnzgsii mooDs; CHLOSIH OBGIIIC
CCIPOH»S: ciioioBtmns:
IIIaCHLOROBIREII; POITCEIOBWHID
fI«»ITLS: POPVtlTIOl RPOSOI8
mtSEICI
Bristol. O.I.
1960
IP1-600/1-80-03*. *0
pp.




















(heaol, p-altro- (• CI)
thesol, *-altro- (9 CI)
100-02-7
e«-»5-w-o3
M 139.11, HF 114.9-115.6 C, BP 279 C (decoap)
                                                                                                                                                                                          to
IXSSII
•3SS
Oriae



IIPOSOU BODTI




1IUTTICU
IZTBOD
SC



•OBBEB
OF C1SIS
12



I1IGE
0-0.5 ppa



8E1I
lot applicable



GEIIilt IIFOM1TIOI
fang* of seaas daring cotton spraying
caaaoa. RonthlT levels correlated
•ith orqaaorhosphate pesticide ase.
Cetton insect scovts, college-aoe,
•orkiag vithcat special protective
clctbiaq, bitalag » ith In 2 hr after
dallr «ork.
1C algns cr «Taptoa« of
orqaaophaspbate poiaoaiag.
levels iavereelr related to blood
ehcliaesterise activity.
IISnCIDSS; tniBOtlTSS; OIIIE;
atOlfS; OieitOPBOSfUTIS:
cccopHiomi guuis; tnnis
FIFEBEJCI
Barns, J.E.
Parker. B.fl.
1975
Archives of
Znviroaneatal
Contaaination and
Toxicology 3:3«*-351



-------
faeaol. peitacaloro-
tl-tt-S
C«-B-CIS-O
SI 26C.3S, H 190-191 C, B* 309-310 C (decaap), TO »0 an >« at  S11.2
TlSSffl

• 356
Blood,
HEM









•357
Hood,
aania














«35«
Blood,
vkole






















msiu lont

akalatlon











I>ka la tl 01









































aiaimcai
BSTHGD





























nic
























IOUZ8
OF C1SES
I 2
1 32
0 T1









•22
















a) 35
b| 12























illGE

) 1.68-1.15 ppa
) 0.116-1. OM ppa
) 0.015-0.055 ppa









a) 0.15-17.* ppa
b) 0.02-7.70 ppa
c) <0.01-S.«0 ppa
4) 0.02-7.20 ppa













a) 3-39 ag/«.
b) 3-15 ng/g






















(III]
mi

a) 1.72 ppa
b) lot given
e) lot given









a) 3.7» * or - 3.99
ppn
b) 1.72 * or - 2.02
ppn
cl 0.25 * or - 0.88
ppn
d) 0.32 » or - 1.25
ppn









a) 13 ng/g
b) 7 ng/g






















P.BB) •" "
61IEI11 IIFO1UTXOI

«) Girls, aqca 2 and * yr. Iron log
teae «itk 0. IK on Interior mod
nc face, 0.2f «
-------
   Chenel, pentaehloro-
   67-85-5
   ce-H-cis-o
   >« 266.35. HP 190-191  C.  BP 309-310 C (deconp) . It 40 H
                                                               at 211.2
                                                                                        (COITII32D)
IISSOE

4359
Urine












4360
Orine














EXPOSURE ROUT

Inhalation












Inhalation















IHLRICIL
BET HOD





























lUBEEB
or CISES
a) 11
b) 33
e) 1











422















I1*GZ

a) 2-87 ppb
b) 1-7 ppb
C) lot applicable











a) <0.01-7.80 ppn
b) <0.01-2.40 ppn
c) <0. 01-0. 40 ppn
d) <0. 01-1. 00 ppn












8E1I

a) Wot given
b) Wot given
c) 216 ppb











a) 0.95 * or - 1.93
ppn
b) 0.27 * or - 0.56
ppn
c) 0.01 » or - 0.05
PP»
d) 0.03 * or - 0.18
ppn








GtlZBil IITOBimOI

a) log hones residents
b) controls, untreated hoaes
c) 2 yr old girl fron log hose sith
0.11* on interior vood surface, 0.29
ng/cn n in air
logs dipped er sprayed with 5*
Fentachlorophenol
Kentucky residents of log bones bnilt
retneen 1975 and 1971 Controls.
10 pentachlorophenol-related health
croblens.
KHT0CKT: (DOLTS; CHILOREI: BLOOD
S1BOH; U3IJI; roiGICIDBS; FOFDLITIOI
HPOSORJ; PBE»OLS
a) Open-vat sood treatecs
b) Pressnre-tank rood treaters
c) Parners or pest control operators
d) Controls

Occspatlonally exposed subjects or
centrols in HI.

Increases in innatnre leucocytes and
rasophils, plasna cholinesterase.
alkaline phosphatase, gnita globnlin.
and nric acid. Decreases in serai
c«.
I111II: 1D01TS; BLOOD SERB"; OBI»H;
IIR1CRLOIOPBEIOL: BEILTB B1ZUDS;
IinaSTRIlt IIBOSPHEIES: IIBU1TIOI
SEFEREHCE

Belt!, 8. I., Ed.
1980
Chenicnl Regnlatioa
Reporter « (26): 823










Kleiner, B.s.
Vong, L.
Sato, 1.1.
Beicbert, B.L.
Korsak, R.J.
Rashad, H. H.
1980
archives of
Environnental
Contasination and
Toxicology 9:715-725





                                                                                                                                                                                            00
Pbatol, 2,«-Jichloro-
120-83-2
C€-B«-C1J-0
II 163.0, IP «S C, BP 209-210 C
TISSUE
1361
Blood,
•kale


















t
t
I
*
XXMSOtB SO DTK






















\
\
t
IMLniClL
RETWD
me





















1
t
«
M01IIR
or cisis
«l 35
b) 13





















t
_l 	
I1IGS
-
•) lot applicable
b) sot detected




















1
«
i
IE1I
•
a) 5 ng/g
b) lot detected





















\
\
GlIEBlt IiroRUTIOl
a) tove Canal residents, 3* (1)
pe«lti*e
b) Talnn teecs
lean of positive sanples. Talnes
corrected for recovery
Closely Mtchcd, sinaltaoeons control
saeples vere not provided for
analysis along vlth those fron tne 36
love Caaal area residents saspled.
tacking neaningfol control or
literature data relative to the
significance of the lo» residnes
fcand in the field sanples analyzed.
no definite conclasions can be drawn
Cron the resalts reported.
Issidents of lev Torr. Controls,
eiployees of the tnvlrouental
Protection agency and (Diversity
stadents, lorth Carolina.
Ill TOM: 1CRH CMtOUIt: BLOOD:
aitsoBmni IRHODS: CBLORIIE oBcinc
ccuponios; cau>BOBtit»ss;
nniCVlOVCBIRllt: KUTCBIOBHITID
1 fUBllTLS; TOlnUIIQl nCOSTIBB
1
lEfERHCE
Bristol, 0.*.
1980
EPJ-SOO/1-80-036, 40
pp.




















1 l
-------
Phenol. 2.»,r-tcichloro-
C6-S3-CU-0
Rl 1*7.5, IT 2S2 C.  It 1  •• 04 at 72 C
IISSBI
*3C2
Blood,
•hole






















EITCSVH tamt
























Hitmen
MTBOD
8PLC













•









IDS in
OF cms
a) 35
i) 13























UK2
a| 2-3 ng/g
t) lot detected























mi
a) 3 »g/g
b| lot detected





















1
1
efttm iBTOSBMiot
a| lore Canal residents, lit (t)
positive
b» Volvftteera
tange ago Be an of positive staples.
Values corrected tor recovery
CloselT Batched, simltaneons control
saaples me not provided for
aaalTsls alcng with tHoae Croc the 36
Io»« canal area cesUeats saapled.
lacklaq aeaninqfal control oz
literature data relative to the
slgalf tcance of tke lev resificei
fooBd In tie fleU sacples aoaljiea.
ae definite conclanioas can be dravn
Iron the reavlts reported.
l«>llents ot ••• tort. Controls,
cnployees of the InTicotaeotal
Protection locncr and naiTerslty
etgdents, lorth Carolina.
Ill JOtK; Km ClBOLUl; BLOOD;
HIlSriSMKlT BBTBOBS; CBLO1II1 OSG1HIC
CCIMBSBS; CBlOBOBEIIHESi
l»tCRIOICBtn»Z; POtTCBLOBUlTEB
tlPS!«LS; VCnUTIOI CTFOSDIE

IEPESIBCE
Bristol, D.I.
1980
IP»-600/1-80-036, BO
PP-





















Ihenl. 2,»,«-tric«l.oco-
86-06-2
C6-B3-C13-0
» 197.5, HP 68 C, BP 2M.5 C, TO 1 an Hq at T6.5 C
N>
-P-
VO

4363
Blood.












































AVtltllCAl
BETHOD
HPLC





















BUHBES
07 CUES
a) 35
b) 13





















luci
a) 2-« ng/g
t) lot detected




















(HIT
""
a) 3 no;/g
b) lot detected




















PiGE)
G"mt "»««««•
«) love Canal resldmts, «» (2)
positive
hi Tolonteers
Bange and nena of positive sanples.
values corrected for recovery
Closely natched, sianltaaeau control
sasilec *ere not provided for
analysis along with those Iron the 36
love Caaal area residents «a«ple«.
lacking neanlngfnl control at
literatnre dnta relative to the
significance of the lo> relidoes
fcond in the field sanples analyzed.
no definite conclnslons can be drain
fren the resells reported.
lesldents of lev lock, controls.
•itloyees of the Invironnental
Protection tgency aid eniversity
students, locth Carolina.
in tOBi: ions cuouBi; BLOOD;
flUSTJBMMT BIT BOBS; CHLOBI1B OBG»»IC
ccaioiiDS; CBIOBOBHZZIIS;
IIPHIITLS: POPHUTIOI EIPOSOIE

tEFIBEICE
Bristol, D.».
1980
1P1-SOO/1-80-036, ao
pp.




















-------
 fhaaol.  2.4 Fro* cord coatrol*
aaol/1 | «] Fro* infants with Titaaln
i) 1.76 » or - 0.31 1 tipplecent
aaol/1 1 (1 Froi infant controls
e) 2. 56 » or - 0.43 I tea* of 10 aa.
uol/1 |
f) 2.73 * or - 0.40 I 506 pregnant voau, 613 pregnant
aaol/1 1 centrals. Scotland.
j
1 SCOniBD; DinCT ntSDOB; IDOT.TS;
t lirins: BIOCI: OBBIHCIL COBB:
I ClICIUl; BTDWITCHOHC»LCIUBOIS;
1 Bisnsng; BIBSULS: nosnosas;
1 T41C? BLBBCB1S; TmnTB' PS OIST5j
I BIIZBlt BRIZOLISB; PIBGItlCT
1
|
a) 3. 51 « or - 0.07 f a| Kaasas Cltr. ts, harl-iater ar«a
•1/100 *1 | b) Kansas City. BO. soft-Hater area
b) 3. 66 * or - 0.04 |
•g/100 il | IS and to reslients satched for age
1 <>*aa agas 37 ana 37.7 rr), sex.
1 langtli of cesldeHe, larltal aad
1 aeonosic states, occapation, naalwr
I ef children, ssoklag habits, it, st.
1
1 I* hari-ratex araa. significant
1 licreaw in kyperteaslon, ICC
1 afenocsalitie*. and kTPecariceaia.
1
I iiisis; iisseni: anBits;
i ciiatoTiscnu DISSISSS:
i Btmnisxci; sroon snoa;
t c«aPUiTiTt triminois: cimitii:
I CUCIB«; cncBini: imtius:
I tieissiva; t«os?Bo»oos! FQMSSIOB;
I sctiasj me: Bioiccmnmoi:
1 ninais BIID
i
IIFESEICB


Cockbar*. F.
Belton, I.E.
P«rTl», I.J.
Giles, B.B.
Browa, J.I.
Turner, T.I.
VllkiBSOl, E.g.
Focfar, J.O.
Barrie, I.J.B.
BeKar. G.3.
Pocock. S,J.
1490
British Radical Jomrnal
28 1(6232): 11-14






Biareabaaa, B. t.
Fleischnan, I.I
9a*n, 3.
mold, J.
1»7S
lancet
H19H):100I-1016















OKI use)
                                                                                                                                                                                       10
                                                                                                                                                                                       01
                                                                                                                                                                                       o
-------
flcarkoraa
7723-ia-o
i
in J0.9737C, m M.I c. B* jga c, n 19 •• i« *t  12?  c
                                                                                   (COETItOED)
ussvt



a 367
Bale




















• 36*
Sidaar























4369
Llw






















XFOS01! ROOT*










































































luimcit
BET SOB
























n
























11























•01 US
OF C1SIS
























U 8

e» 12






















at »
W 9
c| 11





















11KS 1
t
























a) 2*5-39*0 *q/1
hi 373-300* «g/9
fl 215-3310 ao/j
a«t «t





















m) 606-3019 aq/9
b) (22-2315 09/9
c) 260-3600 og/5
•at «t



















(III
•Ell | eSBItll nrOIUTIOl
1
1
1
1 Bavta*. 2* npraawitatl**
I f ca— aaaliaia tractaaata aca
1 tabaUtad. Ika feasibility of a
1 Idllfltlc, ao-nak palter for hair
1 aaalyala l« eatlla«d aad sapportad.
1
1 mm: TSUI nmBts: Din:
1 IDSTBaLTa: BUSVBEIEK BET1ODS:
I eftus; FMTCTS', COBFIUTITC
1 iiiioiTioBS: uonn*; IBTIBOBI;
1 ISSEBIC; Blind; nOBTBE; C1MIOH;
i cuciuB: cnenBi: cBionoi; COBIH;
l ccppM; eiiina: esBiiinoB: COLD:
l lemiu 1101 j LunuTOBj mo;
1 B16BESIII: B1M1ISSE: SEECOBT;
\ tctrmDinB: ncin: THostBoiQS;
1 {CTJ3SIW: 10BIDIOB: SBXinOB;
1 SIIICOB; SILTEK: SODIBB; STBCWTMB;
1 sotroi: ti»: TTTHIBB; TOIGSTIII
1 TIIC; HBCOBHTI
1
1
a) 829 »q/g 1 at Coatcola
b) 1157 nj/f | b) Berkac  I
e) 12 £9 ag/g 1 c» torkat qreap n
•«t «t |
leiliu | caoaasai Mflaery aid saaltac
1 aotkaca, aq«a 5S-76 yr, crpoaad to
1 kaa*r aatal« 1-3 4aea4«a. Tla*
1 batavam tatitmaat a»4 tactk 0-1. S }t
I la icoap I aad 2-19 re, Itott II.
I ccatrol*, a<)«» «3-72 yr, ako U«l SO
1 ta fcoa tb« factory. s*ad«>.
1
1 SflOBB; Claims; HDinS; llTBBi
l Hies; coBfiiHiTE snmTiois:
t ntasTBiii H6II11: msmcBim
1 BIT BODS; lITlBOtT: IBStllC; CIDBIIB:
1 ctsm: CBKISIIJB; coBitt; COFIE*;
1 GCIO: IIOC IlRItBOB: HID;
1 BIB61IESE; BRCOIT; BOtlBIlBITS:
1 ciamnias; IOBIDIOB: SCIBDIDB:
1 SIIIBTVl: SIITEB: TIB; TOISSTEB;
i 1ITC: BSalTB BalllBS: IBDVSmn
1 (iins: SBiiTfflj; Tsuinivi
1
1
a) 1876 «g/g I a) Coatcola
b) »10 «j/9 1 B) Mtkac group I
e) 1S2« ag/9 t c) lortar qtoap n
Bat «t |
Badlaaa | cacaaaal raf laacr aaA aaaltac
1 aotk«ca. iqaa 55- 76 yt, axpoMl to
1 kaarr avtala 1-3 4aea9a«. Tlaa
I t«tM«a ratlraaaat »4 Oaatk 0-1.5 fc
1 1m group I aid 2-19 yr. groap It.
1 Ccatrols. «g«a *3-72 yr, *ko Unl SO
1 tt {TOB tka factorr. Saaflaa.
i stiBE*; cioMMS; Kirans: imi;
1 10BSS; COBP111TITE XT1101TIOBS;
1 IIOOSTEI11 ilOIIBE; VSlSOBEinT
1 B1TSODSJ iniBOtlj HSniCi ClDIKtB;
l CISIHB: cRBoranc coani: corpus
1 SOLO: HOB; 11BTB1BOB; tMD:
1 ii»ciwst: BiictjiTs MtTBDinm:
1 (lOSfBosvs: EOTIDIOB: ackisira;
1 siiifin: snrts; in: IOBSSIEB;
1 tlBC! BEtLTB BU1SOS: IfDOStllU
1 fllBTS; 3BHTEBSI TEUVIIOB
1
C f>61)
BEFBBEICE



Cbittlcboroagh. a.
980
Seianoa of tk« Total
BTlroBieat 14:53-75


















Brnn«, V.
Bordbaro.« Q.
feat«c« V.Q.
1990
sci«*ca of the total
E»lrt>Ba*Bt 16:13-35



















Broaa. D.
Bordbacq. G.
Faster, ?.c.
1990
Selaaoa of the Total
Eavlnuatt 16:13-35


















                                                                                                                                                                                      N)
                                                                                                                                                                                      tn
-------
  Ikospkoras
  1723-1»-0
  t
  tt« 30.9737C, IP M.I C, BP  280 C,  vp 10 » Ig at 127 C
                                                                                        (COBtllTOD}
TISSOS

«370
Inng




















*371
Brine









1
EIPOSOIS BOUT:























lagestion











» MI men.
BETHOD
11




















.
Chen











BOBBES
OF CASES
a) 8
b) 9
0 11



















10











BIKE

a) 38»-2«21 ag/g
fe) 67«-3516 ng/g
c) 1«(-98«* ag/g
Wet rt


















lot given










I
mi

a) 777 ag/g
b> 898 ug/g
c) 799 og/g
Ret vt
ledians

















0.69 » or - 0.1*
g/day










etIEUl IIPOSEITIOB

a) controls
b| torkec gronp I
c) Vorker grovp XI

Cecensel refinery and sselter
lorkera, ages 55-76 yr, exposed to
keavy aetals 1-3 decades. Tine
retveen retirenent and death 0-1.5 yr
in gronp I and 2-19 yr, group II.
Controls. ag«s *3-72 yr. vho lived SO
ka fron tke factory. Sveden.
SIBDBH: ciDifEBS: Kioisys; IITES;
IBBSSs COBPiBaTITB mLDlTXOIS;
IIBOSTSI11 BTGIEBE: lOiSOBBBDIT
BETioDS; inxniy; IBSSBXC: CIDMIBH;
CIStffB; CBBOBIDB; COEUT; COPPE1;
(OLD; IIOB; ItBTMBim; IE1D;
BIBGIIESB; BBSCOBT: BOLIBDEBHB;
fK)SPttO«9S: 61TBIDHJB: SCIBOXOB:
SfLEIlng; SIIfH; TIB; TDBGSTCT:
TIIC; BUITB B1Z1BOS; IIDOSTBIll
Pit ITS; SiBLTEBSi TEUnXDB
less after daily intake of 1.3* * or
- 0.28 g. Data fron *7 7-day
experinental periods.
University stadents and enployees, a
avrse and a teacker. Balliparovs.
ages 19-29 yr.
Fkospkoras talance slightly positive.
reflecting adeqaate intake.
IHEESSE*: OBiiE: iioi: ciiciim:
ilCIESIIg; RIIBBILS; PBOSPHOBdS;
CIETS; IXIZBlt BITIBCLISB; PBESI1ICT I
1
EERBNCE

Brane. 9.
Bordberg, 6.
Vester, P.O.
1980
science of the Total
Environsent 16:13-35
















(she, J.E.
Sckotteld, r.l.
Gran. 8.8.
tnecican Journal of
Clinical Intrition
32:286-291




1
	 1
                                                                                                                                                                                           K>
                                                                                                                                                                                           <_n
                                                                                                                                                                                           N3
Iktkalie acid, bla(2-«tkrlbezrlt ester  (8 CI)
1.2-Benzenedicarboxrlic acid. bla(2-ethrlkezTl) ester  (9 CE)
117-81-7
C2*-B3B-O*
I« 390.5*
TISSOS
• 372
Idlpose
«373
Spleen
IXPOSITBE BOOTE


1I1LTTIC11
IETROO

t
1
BOUSES
OF C1SES


BalG!


BE1I


SEIEU1 IIPOSUTIOI
Beview of effects oa biological
systess with enpkasis on safety
CTalnation aad levels encountered in
aedical devices
iriwsi TTSSOE: spun; BSTII«;
IBTHLIC iciDS: reriBouss;
nitBOLIIES
tevie* of effects on biological
ststens vltk eapkasls on safety
evaluation anfl levels encoaatered in
aedical devices
ttltOSE TISSUE; SPLEtl; BEVIZV;
tmuic tens; BSTIBOLISH:
mnOLTtis
EETEBEBCZ
Thoaas. J.I.
Darby, T.O.
Kallin, B.F.
Garvin, P.J.
Hartis, L.
1978
Toxicology and Ipplied
Pkarnacology *S: 1-27
Tkonas, J.i.
Darby. T.D.
•allin. B.r.
Garvin. P.J.
Hart Is, I.
1978
toxicology and Ipplied
Pkarnacology «S:1-27
-------
Ilatiaaa
74*0-0«-«
Pt
It* 195. Of, IP 1773.5 C. IP 3827 C.  TP  1 u  H« at  2600 C, 10 as 89 »t 29*0 C
iissirs
»37t
HlpOM
»37S
BlOOl
«376
Bair
•377
Kidner
BXPOSRSE BOITE




aflinXCaL
H ETHOS
US
us
us
us
IVRBEt
or CISES
0
83
.
283
10
suet
lot aiTsa
lot given
) lot git«n
] lot glvaa
«J lot giian
lot glraa
lot glToa
nn i SBiiui iiroBuraoi i IEFBBEICE
1 i
i i
I I
1 <1.3 ppb | a) los lagalaa r«sld«a.ts | Jotaaoi, D.B.
I ». ? ppb | ft) Occapatleaallf «xpottd | PreToBt. l.J.
( | Hilary, J.B.
I latopalas, los Itgalas, 12-74 TI olds I Caaau. D.E.
| tit » 51 yt oU *aok«r »ho »U«8 uA I BoMif«U. J.B.
I fioc«ss*d ft. Pi it Ottirio. | H7S
1 | IP1-&00/1-76-019, 235
| tZTlLS; niTIIDI; PUUIim; t!U»J | pp.
t (QPOltnO* IHOSV1B; OCC1»lTIOItt |
1 gillBIS; CIUPOSIH; IDTOPSItS; |
1 tlOOI; XI tills : SPLBZI; Bill; OSJiE; |
1 ivies; mscus: impost TISSVB: i
I inra; comiuTiTB miiatiois; IB* i
1 J1BS1T; Cllltl; milSl atROBOTITB |
i i
I 1
a) <3.1 «g/100 mi [ a) los ia««l«s aad laacastn ( Johiwm, D.J.
b) 0.0*9 aq/lOO ml I taai«««t«. laolTlaaal  inn; CO«P»I»THI ininiuoas: m i
I JtBSBTi CIIIC1: iniM; mOHOTITI |
i i
I i
<0.05 a?/g | lot lioalcs lad Lancaster EMlOots I Johana, B.S.
1 I vc«ost. t.J.
1 Callforalaaa llTiaq ao«n»i»4 froa a 1 TUlar?, J.B.
1 (r«*»ay 1> los iigclas or 1* tka klot 1 Caaaaa, O.e.
1 ats-art roctea of Lancalter. lq* I BosaafeU, J.e.
1 gtoaps; 1-61. 17-3*. 35 or aot« TC> 1 1*7i
1 «0t «alt«. »W loa-ihlt« ia las | BP1-«00/1-7C-019. 235
t laaalas. 80* vtita. JO'S aoa-«1iit« U I pp.
1 lageaator. I
1 1
1 tit us: IIIIHOB; riiiiMOB; IBID; r
1 (OPIUTtOI tXPOSVKZ: OCCHTMIO111 |
1 UZaBES; CILirotlll; iDTOPSItS; |
1 BtOOD; CIDKIS; SfllH; H1IBJ VHIB: 1
| IOI6S; SDSCIES; 1DIP03! TISSUE: I
| IT1B1; COBTlMTln mWitlOIS; IB1 t
I iiisBT; emu; inriia; HITOBOTITE t
i t
<2.« ppb | tea *mo*laa milnta | jahasoa, D.B.
1 1 Frawst. t.J.
I autopsies, 12-7» yr olas. 1 TiH«ry, J.B.
1 1 caaaan, D.B.
1 tnus: TimnB: PUIIIIOB; LBUI i nsoafeid, J.B.
| iOSOllTIOI tlPOSBK; OCCOPKIOail 1 1»7«
1 Bins is: cuirosiii; IVTOPSIBS; i tM-«oo/i-7«-o». 23$
t HOOD: titiiTS; snEBii BIIB: OBIIB: i pp.
1 iwesj aasciis; IDIPOSE nssoz; i
| tltt»; COHPalltlfB BntVltlOU; IBB 1
1 jt»BT: ciini; BniK; IOTOOOTITI i
i i
tint MGE) ' 	
-------
ruttm
7WO-W-*
Ft
»M 1*5.09,  I*  1773.5 C. B* 3827 C. T» 1 «• »9 «t 2COO C. 10 •• 84 at 24*0 C
                                                                                   tcorcmmi
1
1
1
1
ttsssi
«J7t
tl«r
«37»
t««
«3«0
B
•Ot fiTU
BMB i sBBitti imiiraoB I immcs 	 '
i i
<0.2« ppb | Io» 1>9*1«* cai4mti | Jaks«o>, ».«.
1 1 *r«TO»t. S.J.
I lltapiiM. 12-19 it old«. | TillMf. J.B.
1 1 Camu, 9.B.
I sntis; KJimi: »iu»m: t«»; t lowitcu, i.g.
1 rerramoi nrosni; OCCPPITIOMI j i»7«
I IIM1C3I CIIIFOIIU; kITOFSIBSt > t?t-«00/1-7«-019, 235
1 HOOD! KIBMIS; SniH; Bill; UHII; | pp.
1 idlest nsctts; UIKSI nssoi; t
I inn; cotPtuTm inumois; tvi i
I jetsrr; cuict; BIBIMI totontm i
*) <1.3 ppb | •) tos Ii9«l«i t««13«ta | Jokiwom. B.S.
») 3.T ppb | t| Oec«p.tlo««llr •rpaOT4 | tmemt, t.J.
1 1 Till try, J.B.
I litop«l««. to* l««*ln. 12-7» yr alts I Own, ».».
I »a • 52 Tt eU rto *ta«« ud I Boamtcld, J.B.
1 fioeMMt Ft, Fd i» Oxterie. 1 im
! mo., »«mi, F.UOI.B, lun ! »f-*°fl/1-7<-ow- M5
t toinmoi nFosoii! occmiTioiti i
I milts: cuiroinii inoFsiis; i
1 BIOODJ nntis; spttM: BIII: unrs; t
\ tnss: iffsctcs: IDIFOSE Tissoi; i
I Hint coRpmnrs zntnnois: 13* i
I JHSBT; ciMct; lima; anoaotm i
i i
• i 	 	 ,' 	 	
«) <».» ppb | *> los 1>?«1<« n«t4«t> | Jok.wi. D.B.
b> 2S.O ppb 1 t) Oeeapatloully •zpowd I Pr.TMt, J.J.
1 I Till«j. J.B.
1 »ltop»l«8, m li^ilm, 12-79 ft olds I cum. B.E.
t »d * 22 TT old nokir 
-------
»t
    m.«9, 0 1773. S c.  BP  3i27 C,  TP  1 M  Rg «t 2600 C,  10 •• Sg at 29*0 C
                                                                                     (coniivio)
nssn
nn
Vrln

















mosnu BOBtt



















iiumcii
RBTBOD
us


















mm
at cms
a) 213
b) <

















•MSB
a) tot glim
b) 0.23-2.58 ig/1

















nu
a) <0.6 «oyi
b) LOT 09/1

















6EIH1I I1TOI1UTIOI
a) lo« lag«l«a aid la»ea«t«r
z**id«Bts
11 Oce«patlo»llT «xpowd

CallteTBiaac li.Ti.Kj domviad from a
fr*««T !• los 1*9«1« or ii th« higk
ItMrt c*qlo> of lamca«t«c. kg*
qrotp*: 1-K, 17- 3», 35 ot mor« jr.
COf «kit«. *o< «m-«Ut* li lot
U4«l«s. ««« *Ut«, 20« UB-vhit* IB
I>ica«t«c. !•« J*C<«T r«fi»«rr
•ottir*
JITU3; H-ltlWH; fltUDIDl: LIU;
to?nmoi nposmti occnettioiti
•nuts: ciinoint; IOTOPSIIS;
HOOD: ximiTS: snt»; BUI: ami:
i»«st nscus: igitosi nssns;
inn: comtuTin imautaist HI
JIISIT; CtllDl: 8II1BS; IDTOIOTITS
tmisicx
Johaioi, 0.1.
PrVTOBt, B.J.
Tlll«cr> J-3.
Caiun. 9.1.
«OMBt*U. J.B.
1«7«
IPl-«00/1-7«-Ot9, 23S
PP-











PlubaM. cklorotrirtkyl-
1067-M-T
e«-«is-ci-Pb
•* 324.9
1ISSDI
«3*3
idr*Bal
glaaft
»3»«
•loot
•3«S
IralB
txposoiB tons



1ULT1ICM.
BRBOD



«8BES
OF CiSES



met
-


HIM



etmii nroiamoi
>6»: nsBis: POOD
cotMHiuTioii rons: usoLin;
enmc tmcrs; mvsniii
icciDtns: imitRai: HBBH tstis
**Ti«. ToiicaklMtlo aad to lie
•ftcctB of ocgaaolBad coapoaBdv*
eirtBat occiiitloul and
•BTlcoaBoBtal (ipoiit* data.
•IITtO StlTIS; SVBOPt; IEW CietRIC
cctKmiBS; imoBotm; in PcitmoB;
<«iciiosti: ftsBis; FOOD
com«m?ioi; runs; sisoini;
entile iincn; WDUSTSIII
iccieiirsi iHuinov; UIBII uiu
Kria*. ToxleoklBotles aad toilc
•tfocti of otqaaolcad eoapoaads,
e«tr*>t ocetfatloaal aid
•artragMirtal KBOBBC* d*ta.
eiltlt STITtS: EIBOPI; USD CB61RC
coiFOTiDS; amoRoiiTB: in PCIIOTIOB;
ciiciKaii; nsBis; TOOD
COITlRIIHIOfi TOESS; 51SO1IIB:
cnrrrc CPTICTS: noDsnui
icetgiRS; tmunois isti* IBEIS
t
tirBIEICI
GzandjaaBi p.
IlclMl, T.
1979
Kealda* Barivwa
22S97-1M
ecaaljoan. f.
IlslMi, I.
1979
ItBSldW S«ll«»S
22:97-1**
GzaBdfcaa. p.
Uelaea, T.
197»
s«si.4m BBTlwis
22:97-1*1
(HIT pun
                                                                                                                                                                                         Ul
                                                                                                                                                                                         (Jl
-------
1«7-1*-7
C6-B15-C1-M
«I 329.1
                                                                               Ccomvtm)
TISSUE
«3«6
B««rt
»387
«3I8

4390
•aacccas
«391
I
EIPOSBBE BOUT






immcii.
IITBOP






rrasn
or c»sss






BUGS






m> i 6MI1U xmtiiTxei i EEHSEBCE
i f
i l
1 Mvlo*. ToxicokiMtica- and toxic 1 GraadlaaB. P.
1 «f facts of orgaaoload coapoonds, | Bi«lMB, T.
1 cort«Bt occvcatioaal aad I 1979
1 €BTirOBB«Btal *xponr« data. t B«sU«« B*T!««B
1 1 22S97-1U
I IBI1IO ST1TH; ITOOPB; LI1B CBGMIC t
1 CCBPOVflS: IROBOTIVE: III PCLIKXOB; |
l CHCIBOSH: USB**; torn i
| CCRlBIBinOB; T«BXS; 61SOIIBE: 1
l SIBRIC tiptcxs; IIODSTBIU i
l icciDEBTS: iwiiMiati trsBtf IBHS i
i i
1 i
1 Bavie*. Toxieokiaatiea and toxic t 6raadj«u. P.
1 affects of orgtooUad coapoaala. | litlatc, t.
1 cgtrut ocncatioaal and | 1979
1 " 1 22:97- 1M
1 oimg sTiTis; sraopt; tew nsanc i
1 COBPOmSS; iniOSOTITE: III PCIIRIOB; I
t CISCIBOBIU fMIIS: fOOD |
1 COBIIBIB»IIO«: VmtS; S1SO1IIB; I
I eiBtric crrscTS; mosisiu i
l iccxpnrs: iraitiTxai: nati IBUS i
i i
1 l«»ie». Toxieoklactle* aad toxic 1 CrudTaaa, P.
1 •tf«eta of orouolMd oovpooads. | Bialaam, T.
1 cirtmt eccafatioaal aad I 1979
1 *atiroaa«t*I •xposace data. | P«»ia«« g«ri«r*
( 1 22:97-1*8
1 BBTTXD 1T1IIS; EOBOPI; »AD CJSMIC I
1 CC9POOVBS; lUTOHOTITB: 111 POllVTIOB: |
1 CIBCIBDSK; flSBES; FOOD |
1 CCBTIHMTIOB; THUS; eiSOIIBZ; |
1 CIBRIC SriBCTS: IBODSniU I
1 iccnrars: IBBIUTIOB; TOBIB IBIIS i
i i
i i
I !•*!•*. Toxicokiaetica aad toxic I Graadjaaa, P.
1 aifacta of otvaaolmd ooapoaads. I Bielaaa. t.
1 citnat cceicatloaal aad 1 1979
1 »«Tlro»B«0tal oxposat* data. I Pesidne Sawieas
1 t 22397-1W
| VBXRI SIIIIS: EOBOPB: 1113 CIGIBIC I
1 ccBpcrais; ittoRcnrs: ax* rcivmoi; »
l CHCiiosm: IXSBES; POOD i
l coBTiixiiTiOB: raiss: eisoim; i
1 CIBRIC inters-. IBBOSTIIU i
l iccxonrs; IIBIUTIO»: OBBM IBIIS i
i i
1 l
I !€*!•>. toxicoklMtica aad toxic I Grand 1«aa, p.
1 *ff«ets of onjaBol«ad coaponada, I Heist t, T.
1 corrent cecacationtl »d I 1979
1 tiTlroBMBtal •xpomca data. I Besldaa B«ris»a
1 1 22:97-1*8
1 OBITED suns.- tmort; IEU cseinc i
l ccBpcgBos: amoBtmtx; us paimioB: i
| CISCIBOSIB; TISBIS: POOD |
I ccBTiiiuTioi: rnns: eisaxiR; i
1 sunic srrecrs; IIBDSTSUI i
1 iccntRS: iBBtunai; OBBH IB us i
i i
1 l "
i ««»ie». Toxlcoklactics aad toxic 1 eraadjoaa, P.
I affacts ot oigaaolaad coapoaats. t BlelMa. 1.
t c«rr«t eccatational aad I 1979
t «niroBa«Btal vxposnr* data. 1 Casidne S«rie»s
t 1 22:97- 1»»
1 tiBTno sTiits; IBBOPE: LIID CXCIBXC i
1 CCBfOVBOS; IVTOBOIXTt; KB PC1HJTIOB: |
t OBCIBOSIB: IISBE5; MO9 I
I ccBTMiiiaTiOB: rnns; cisotnt: i
l eiiRic inccis: IIBUSTSIII i
| ICCIfiinS; 11S11ATIOB; OTBH 1511S |
' - t
-------
          eklo»trli«tkrl-
•1 287.77
tissm
•392
Drln









BIMSDtl lOtRC











itiimcii
BETROD











iraitt
OF C1SSS











UMH











BSlB
.










-
eniui xtroBBiTiai
(«!•«. 1axicoki«*tie* »»4 toxic
tlfccts of orgaaotead coipouda.
decent oeemcatlaul *ml
(ETicoiMitil eiponr* data.

tlTTZD 3TITI5; 101OK; IZ1D CBOHIC
coBEOtmos: IBTOHOTITB; in raionoi:
CIKttOGtl; TI58K; MOD
ccntBiiMioi; rons; cisaini:
eiimc ti tiers; iiovmiu.
ICCIDMIS; IIBIIITIOI; 5BB»Ji 1BU3
BITHEIC!
Ciaaajui, t.
li«lMD, 1.
1»7»
K»llie E«tl«»»
22s 9 7- 1*S






        , t«tr>«tkrl-
78-00-2
CI-BIO-Pb
g« 3Z3. »5. 4? 125-150 c, BP approi 200 C, TF 1 m Bg at 3«.» C
tiasai
•»3
11004
139*
Btla»
nrasmc EOTTI


UllTTIClI.
BITIOO


•TIBBn 1
or cisss


SU61


mil


Sttllll 1IFOIB1T10» |
1
1
•cftn. ToxloaklMtles aad toxic
•fleets of orgaaolaal cocponds.
cictvat occafatiooal and
««Tlroi*««t*l •xposat* data.
0»I1« SUTtS; fOton; UU CB6MIC
ccipotuss; unoaoTUB: in PCLIOTXOI;
CIBCIIOS1I; flSHBSS IQQD
coiT»ii»»Tioi; rums; GISOIIBX;
EIItTIC XIItCTS: IIDOSTBI11
ICCIDIMS; nauiTioi: nsaii tiiu
f«vi«v. Toxicokiaetics and toxic
•tCcets of ocfaaolvad coaiiott»S«.
cocreot occafatioaal a»d
• evicoaMatal eipoavre data.
DIIIID suns: ztnoPE; iziv CRGIIIC
COBfOIJlDS; imoBOTITB; UK PCU.DTIOH:
ciBcnosH: lisa is; FOOD
cciriBi!HTio»: tans; eisotnx:
GIIITIC tillers: noosmii
1CCIBMTS: IIBltlTIOI; VBBtl 11US
tXTEBZICB
CC&aijc*D, f .
nielMB. T.
1»7»
gcsidie S«Tl«a
22:97-U8
Grand jeaa, T.
HUlMIL, 1.
H7»
Kealdae B«rl»s
2S:»7-1«8
                                                                                                                                                                                         Ln
-------
Tolybronlnated biphenyls  (Bo postings  i» CBiniR).
TISSBt



»39S
Blood
























«39«
Blood,
plan*



















4397
ood.
sens

























ETPOSB1E WOT

















































gestlon



























imrticit
MTBOD


8C/BS
























6C/BS




















6C-EC



























BOB an i sites
OF C1S3S |
1

21 I a) 1.1-57.3 tg/mg prot«
I b) 0.03-0. CT »g/sg
I protein
1 c) 224-282 ng/eg prot«i
1 4) lot detected

I
I

I

I
1
1

1

•
1
1
1
1
1
1
t
1
1
1
21 | a) 0.13-10.2 ng/ng
1 protein
1 b) Wot detected
1
1
1
1
1

1

1
1
1
1

1

1
|
1
1
290 I a) lot given
1 b) lot given
1 c) lot given
1 d) lot given
I e) lot given
1 f) lot given
1 g) lot given
1 h) lot give*
1
1
1
1
1
1
1

1
1
1
1
1
1
I
|
1
1
1
»
nil i ciniu IIFOBIITXOI
I

t
a) 23.75 ng/ng 1 a) leukocytes. » exposed chenical
protein 1 icrkers
b) 0.35 ng/ng protein I k) Brythrocytes. » expos*! cheeical
c) 253 ng/ng protein | workers
d) lot detected I c) Beta-lipofroteln fractioa, 2
j «xpoeed ckeeieal workers
1 d) Leukocytes or erythrocytes, W
| csbjeets. including ezpoMd dairy
1 farn residents and controls.
1
1 Bichigaa ckenical workers and dairy
j fare residents exposed to Firenaster
j IF-C. Controls, dairy far* residents
j ie liseonsin.
1
I Stimulation dysfnnetioB of
j lynphocyt*sl tested *ith
| rkytohenagglitiBin and pokeeeed
I nitogen, especially in the * exposed
1 ekeiieal verkers.
1
| ICITBJO1II1TID BIPISITLS;
1 IlTtnOCTTIS; BLOOD niSHl;
I IIOKOCTTIS; HCHieil; IIDOSTtTIL
| IlirtS; IIDDSTBI11 ICTOSPHEBISi
| IIDCSTKI11 DISE1SSS: IISCOISII
I
1
a) S. 1* ng/ng protein | a) 4 exposed ckenical workers
b) lot detected I e) 18 sab-fects. laclwdiag exposed
I dairy fare residents and controls
1
I Blckigan cheiical workers aad dairy
1 farn residents exposed to rirenaster
1 EP-6. Coatrcls* dairy fars residents
I In llceonsln.
1
I Stinlatlon dysfnnctlon of
I lyapnocytes, tested with
j piytoheingglatinln and pokeweed
j eitogen. especially in the * exposed
1 ekenical workers.
1
| fClTBiOIIMTID BIPB1IT1S:
| UTTnoCTTcS; B100B FLlSBt;
| IIDROCTTIS: mCHIGll; IIDOSTIIIL
1 Fiins; iiDosrstai ITBOSPBEIFS;
| IICOSTBIll DISB1S1S; WISCOISIW
1
1
4.23 ppb I •! 1*» sales
2.72 ppb I t) 1(3 fenales
2.75 ppb | c) 0-« yr of age, 33 soblects
7.08 ppb 1 d) 5-8 yr old sales. »0 snblects
a. 32 ppb | e) 5-8 yr old fenales, 37 sablects
3. 18 ppb I f) 9-12 yr cf age, 81 subjects
3.»5 ppb f g) 13-16 yr old nales, 59 subjects
1.87 ppb t h) 13-16 yr old feeales, «3 subjects
1
1 lleklgan children living on
1 Pie-contaninited fans or children
1 censoeiag neat or nilk froe these
t fares.
1
1 lo significant association of
1 atnoraallties and seres PBB levels.
1 Significant negative correlation
1 tetween Hunter of reported synptons
1 aid oer«n PBI.
1
I FCITItCHIKlTlD IIPHBniS; B1OOD
1 si80«: CHn»in: ncwietii: nscoisii;
| TCtD COB1»1IHIOB; 1IIH11
1 tOPDHTIOlS; TUBS; COBFllVIIVB
| miUlltOIS; BtOIIIB 01111 1C
| CCBIO019S: Sit; X6B: BlaltB BIX1B9S;
I tins
i
UriBEICB



BobOI, J.
Snznkl, B.X.
Bexesi, J.E.
Bolland, J.F.
1980
Journal of
Bnvironnental Pathology
and Toxicology
3:3«3-37i



















Boboz. J.
Suzuki. B.K.
Bekesl. J.6.
Holland, J.F.
1980
Journal of
Eavlroueatal Pathology
and Toxicology
3:3*3-378













Barr, R., Jr.
1980
Environnental Se search
21:255-27*
























                                                                                                                                                                                     N3
                                                                                                                                                                                     Ln
                                                                                                                                                                                     00
-------
 relrferoalaatad
                        l»o pe*ti»9» la
                                                                                (cotnimo)
IHSM
•3M
•Ilk









•HOSm MDTC











1M1TTIC1I
IJTBOD











mm
or CISBS











UKI











m»











CEIfUt IIFOBBITIOI
_
l«i*v of Mr«aaat«r coattalntioB ef
cattl* e««d la Bickiga» ul
T«eon«4*tiau for anslag lotlwra

jipii: ignis; Hurts; ssn
Bisiisis: ntxr imn:
fOlinOinillD BIPHMTIS:
tCIYCHlOMIllIB BIPBWTLS:
iioiccomiiio*; mi iiriisins;
iocs coniuuTioi; rooos; LICTITIOI;
pofjiiTioi inosvn
unmet
Rilltr, I.«.
Tinb«rg, 1.
1ST7
Jonn*l at Pediatrics
*0 (3) -.510-512





.
tetwslM
1»
I
                  c.
                                   100 M sg »t wo c
TISSVZ

•3*9
Hood.
aartta
















a»09
Iraata









aalr








nosou SOBTE




















Inhalatlaa



















IHLTTICIJ.
BBl'BOD
US


















mi










us








•BSSSS
or cisis
«1 2«0
b) 260

















1










a) 31
b) 22








11TCS

a) lot gl»«»
b) lot gl»««
















-
lot gl*aa










a) lot alvaa
b) lot gl*an








mi

a) a. 11 » or - 0.05
M^/l
bl *.32 + ot - 0.03
aaq/1















10S.O ng










a) 1359 ppa
b) 12W ppa








GEIIttl mOSIlTXOI

at taaaa* city, IS. k*rd-aat«r am
b) Kaasaa City, to', aoft-vatcr ana

IS and HO raaldaata aatch«d for aq«
laeaa aq«a 37 and 37.7 re) . aex.
laaqtk of caaidaaca. aarltal ana
«eoaoalc atatu. occapatlon, aaabar
of eklldcaa, aaoklag kablta, it, »t.
la bard vatac araa, algaitlcaat
leeraasa la fcTB«ttaaaleD. TCS
ataoraalltlaa. aad krpcrnrlcaaia.
I1IS1S; dlSSCVBI: 1DOLTS;
cijtiOTiscniit gissisis;
BtPISIEISIOl; BLOOD SBBUB:
CCBHSlTtTl miOHIOIS; C1D8HS:
CHCI09; CBBoaina: LITHIDB;
tienstnt; nosrsnsoos: POIISSIOB;
SCMDS; tllC: SlOUCCtrauHTIOl;
tlllKIIS 1HIB
( 1 saaplad at rat* of 1 1/aln, 2-10
ala aftat bnralag * arc vaiaiaq rods.

DilTcrsltr pkyalca shop, Tlorlda

Tionot; linns; Bi»TB: cucins;
cno>n«: cnomB: CCP»I»; IBOI;
HID: aiieiiisE: ncm: foiissiim:
SOlTIl; fnillOi; T»1BI1!I: II »C; 118
*oimto«: FOBIS; iievsmu
itMsrann; tiici nirairs
t| Coatrolt

laanisg dlsaalad and aerial 3rd aid
«tb grada atadaata la Caaada.
citcnu MSBSins: roussina;
SCCHJB; CUJBTOB; COB11T; COPPER;
isci: ism: uicmsz: ziic;
cncBinx; LiTHina; uncogT; sntis-.
nit: cnxtDizi: ciiiDi
1BTIRE1CS

Blaraabaaa. H. I.
Tleisctiaa, I.I

Icnold.'j.
1975
lancat
1(19ia) :1008-1016












•kselxzon, K.E.
Desaedelevc, E.G.
Johaasaov. T.B.
»ioc»e»ter, J. «.
197«
laaals of Occupational
IT?1«« 19:225-238




Pihl, 1.0.
1977
seine*
i»a(a3i3i:20*-20t





(HIT MSI)
                                                                                                                                                                               NJ
                                                                                                                                                                               Ul
                                                                                                                                                                               VO
-------
  Potassina
  7MO-09-7
  K
  >t*  39.096,  HP 63.2 C, BP 765.5 C, Tt  100 mm  Bg  at  590  C
                                                                                       (COBYIBVED)
TISSUE

M02
Bair

















>>03
Heart







Ezposvn Boon





























1BU.THCU
HITBOD



















Plaae photometry








BOBBEI
OF CASES



















al «
b) 7







BAEGE




















a) 0.035-0.086 mSq/g
b) 0.068-0.082 iZ9/a
let »t






BUI




















a) 0.063 * or - 0.013
aEg/9
b) 0.07* » or - 0.006
aSq/g
let >t




61BI1U IIFOEB1IIOI

l«rl*>. 2« t«pr«sentatiT«
Ft«-aaalysia tr«at>«nts arc
tabilat«4. Ike feasibility of a
tollatic, no-»«s» policy foe kair
analysis is out lined and sapporteij.
flTII*; TB»CI BIMSITS; BUB:
ItSTBiLIl; niSUBMZBT SBTBODS:
CIT1LS: PEOTZIBS; COIPIBlTIfZ
ETlinniOBS; 110BHOS; MIIHOIT;
ISSIIIC; BIBIUB; BIOB1IB; CIDRIDH:
C11CIDB; CnCRHBi CnOBIDB; COBilT;
CCFPIB: 3111IUH; GBIB1BIOB; COLD:
IOBIIE; IBOI: HBTBlBtlH: LUC:
SIGSISIOB; IUS1IESB: BBKCDRT;
cciTBomi; imn: PBOSPHOBDS;
pcTissran; SUSIDI09; sBtzBim:
siiicoi: sjiTKB; SOOIDR; STBcnivB:
sniroB: TII; TITIIIDB; TOIESIBI;
?i«c; zncointB
a) Sxlden death fros ischeiic heart
aiaease
t) Sullen oeath fro« ttaaia
Veatcicalar ayocardiva

< 60 TC olds

B1GIBSIOB: POTISSHJB; BZ1B1 EIS.B1SBS:
tiropsizs; BfisT: imis
I lirlBBICZ
t
Chittleboioagh, S.
1980
Science of the total
taTlroiMat 14:53-75















JohasoBr C.J.
Peterson, D.8.
Ssitk. Z.K.
1979
laericaa Joornal of
Clinical latrition
32:967-970


Piopaae
7«-98-«
C3-H8
SB at. 09, BP -189.69 C, BP -«2.1 C, TP 100 •• Eg at -79.6 C
TISSUE
MMAk
Breath










EIPOS02B ftODTZ












illLTTIClL
HETBOO

OC/HS










VORBEB
OF CASSS

_










BUGS

Vot detected— 2. 2 noXbr










(BAB
0 8 Qd/hr











GPItlll IirOBBlTIOB

•etabolias. Bo other details giYea
Cryogenic saipllig techBlqoe.

Bealthy eilitarr and civilian
eaployees, n.S. air force School of
l«rospae« Bedieii*, aaes 23-*7 yr. 3
stokers.
tlBZBUBS; CBIOTIHTBC 9TDEOC1BBOIS:
CBIOKtn OI6IBTC COBPOOSDS:
CBIOBOBSBZZBZS; naOBIBE COBPOOIDS;
III1TB; 1ICCBO1S; THIS; » DOITS
BZnBZBCS
Conkle J.P.
Caap, B.J.
Sslch, S.Z.
1975
Archives of
Environmental Health
30 (2): 290-295





-------
 fropaae, 2-aitro-
CJ-I7-B-02
H 89,09,  BP  170 C,  TP  TO  •• Bg at  IS. 8 C
IMSOB
sao;
Breath











BTPOSBBB BOBTB













iiiiTTicit
KTTOD
SC-BS












Of C1SBS
S« (3*7
staples)











MBSI
lot qlrea
•











mi
O.aos nq/1
Seoaetric











eiitUL urasRitioi
Masacad at 25 C aad 760 aa Bq
11.1V occvrraac*
loer aid upper oae-SlqM Halts
0.111 ud 1.3* ftoyi

laaltkr. t8-JS yr old. noaaMklaq,
artan blacks and Caucasians.
Cbicauo, II. Ilqldlr coattolleft
«Dcriae«tal eoadltloas.
CB1CBIIITBB BTDBOC1BBOIS; TOliTILE*
cesmc coBtcnos; HBJLHE HKIEBS-.
HHiUTIOl: 5BT1IOLISB: BETlEOlItES:
popirnTioi iiposintB: OBB»« IBEIS
EEIEBUCB
KrotoazTnski, B.K.
Brnaaav^ G. R.
O'ReUl, B.J.
1979
Jotmial of Analytical
Toxicoloqi it 225- 23%







Proplonie aclj. 3-aaceapto-, etkyl aster  (S CI)
l£op«BOle acid. 3-iorcapto-, etk^l eater  (9 CI)
:t«6-06-l
e«-aio-o?-s
ni  13*.21
TISSOB
aao«
Braatk












BXCOSIIB BO1RB














alULTTXCaL
Hit BOD
SC-BS













MBBBES
OF ClSSS
W (317
samples)












ttlEI
lot given













Ull I
5.3 m/i
Geoietrlc












SIieBlL IITO1H»I01
reaanred at 25 C ud 760 aa Bq
21.2* occacrence
Lower aad apper oae*slqia llilta 2,S
aid 11.2 9Vl

aealtkr, 1S-35 re old. vonsaoktaq.
at tan blacka ud cancaaians.
CUcaqo. II. ElgldlT co»troll«l
•ipcrlaeital eoadltioia.
IBUTB; ElCCBOLS; 1111 IO1S; 1DQ1T5;
Ctla»IliTlg BTOlOCaSBOIS; TO1ITHB
CtSllIC CQItOQIDS: SB11TH B»HB5S;
iisiUTtci: nmoiisH: BITIBOLITES:
(O;HUTIOI BIPOSIBB: HEBII HE us
SMIBISCB ' |
Frotasiynaki, S.K.
Bconeaa, C.a.
O'weill, H.J.
197*
Joacaal of laalrtleal
Toilcol<*31 3: 223- 23*








  iroplophmoae (8 CI1
  1-PTOpa>o«e, 1-phanyl- {9 CI)
  S3-55-9
  M-H10-0
  B« 13«.2, RP 21 C, BP 218.0 C. TP 1 a* ft? at 50.0 C
MSSUE
MOT
Breath

ziposim BOUTS


ifumcii.
BETBOD
GC-BS

IDS BIB
OF CASKS
5« (387
euples)

EIIGB
Vot givea

REII
0.261 ng/1
Geoaetric

GEHBIL nfOMUIOl
Beamced at 25 C aad 760 aa IKj
2*.a« occ«ct«Dce
lever aad neper oae'Sigia Hilts
0.05* a*d 1.1» nq/1
BcaltkT. IS- 35 it old. nonsaoklnq.
actan blacks aid caacaaiaaa.
Chicago, 11. Biqidlr coatcolled
HIKB-, IICCBOLS; IlltjoiS-. iOULTS;
CB1OBI»»TID ETB50C4BBOIS; TOltllLS
CECinc COIfCnDS; SMITH BlIiBDS;
1IBIIKICI; SETJKL1S1: BET1BOLITES:
ECPfltlTIOf 1IPOSUBE: 18BH IBflS
fiZTBBZICB
KrotorryasXi, B.K.
Bmnaaa, G.I.
o>Welll, B. J.
W9
Jouraal of analytical
Tozicology J-.225-23*

-------
         »lcohol  (8 CIt
  1-tcopMOl  (» CI|
  TV23-»
  C3-«»-0
  « «0.1,  W -117 C.  OT  97.19 C.  n 10 M *t lit W.7 C
tissrrt

Bnatk










**09
BCMtk











HIPO50IS xore
























imrrtoi
»mo»
ec/ss










SC-BS











IVBBEt
OF ClStS
S









......
S» (387











iliei

lot d«t«ct«4- 1400.0 ««/kr









	
lot glT*a











•Ell

175. « «j/kr










21.1 »«/!
MOM trie











BEIIUt Xiromiioi

CecpoHd related to oorial
Mtabolln. la other detail* aim
cryogenic saipllBa tecktiqve.

•eeltfcT allitarT Aad cirillav
**plOf*n, t.S. Hi rorc. school of
Krorptc* KllclB*. *?•» 23-*7 jr. 3
s*ak«*.
Btnns; cnatiHTiE BTDIOCUBOIS:
cnoinv oteinc COSPOBIDS,-
CBiOMinznis: ruoun COIEOORSS:
E1IITB: ItCOBOlSt TIUS: 1D01TS
!»•««! »t 25 C MJ 7«0 n aa
50. Jt oce«rr«e«
tCMT Ml IppW OU-SlgM lllltl 3.9
ail 11*. 1 »q/l
B»althy, 18-35 TC oil. ooBiMklK;.
vxt<* blAcks ud Cftcotflua.
Cklcaao. IL. llgldlr coattJllod
• iporlMitil onaitlooB.
MIITB; JUCCBOIS; IU.HOIS; 1DDWS;
CBIOIIUTZD EniDClIBOIS; fOllTIl!
cusirrc COBPCITWBJ: asirrs BIZISDS;
IHUIIIOI; IET1J01ISB; *M»BOimS;
POPOIIIIOB ttPOSVEB; 1SB1I ISStS
tERSEICE

Covkl*. J.P.
c«»p, B.J.
Mick. B.I.
197S

VBTicoBBental Maltk
30 (2) 5 290-295





rcotamrMki. B.X.
Iramtc, S.3.
O'Mlll, S.J.

Joirtil of lutytlcal
Toxieoloaf 3:225-23*








Prapria  (• Cl)
l-Pro»T»« (S CI|
T«-99-7
CJ-»«
•i 40. »s. nr -10* c. tf -23.3 c,
                                     387C •• 19 «t 20 c
TtSSBI

BTMtk











Etpajots lomi













1 iiitrticit
•ZTHOD

ec/HS











fVBBES
OF C1SSS

8











MKE

lot 4«t*ct«d-2.3 mf/kr











W»I 1 GIltllL IIFOK111IOI
t
1
I
O.S «g/kr ( CC*F««I] c«lit«A to nonsl
1 Mtabollsi. lo ot*»t tetill* 5lT»»
1 Ccyaqvalc mpllaq teclniqn*.
|
1 B«tltkT Illitur ud clTlllu
1 «plOT««», 0.5. tic P»c« School of
{ l«ro*p«e« ftdleln, tgn 23-*7 jr. 3
1
1 mints: ciiotimm miocitaois;
I cnosm omnc coipanvs;
I cnoBotmtns: nvoan coRpogim;
i mirs; ticcioLS: TRIS; IBOITS
i
uniEin

Coakl*. J.]>,
C««p, 3.J.
«*lck, B.E.
1975
IccklTci of

30 (Z): 290-295






-------
 llfcldiai
fb
It* «S.««7«, IP 39 C, «P <•• C,  n 10 mm B? at 3»0 C
1ISSV1
Mil
Braia
»»«
, lair
Mil
••met

RIOStltl tOOTI




aMITTXCU
RETROD
n

n

»n»BEt
or cure


•t 7
b| 3

MICE | Bill | GtiniL motlatlOI
t 1
< 1
1 1
1.6-4.6 »9/9 (nt «t) I »1 3.0 » or - 1.2 I a) laics, c*t*bru, 6 mblacts
1.«-2.« «j/9 (»«t «t) | ao/g f«at »t) | t) F«ial*B, c«r«brn, 3 *«t »tl I b| 2.3 « or - O.M 1 c| Bal««, c«c«b«U». S nbjecta
1.1-3.* «j/g (nt «t| | uf/g <««t it) I 4| F«aala>. oanbellaa, * aabj«cts
|c| 2.3 * or - 0.*3 1
I «9/9 {»«* *t) 1 Tcoi a qcoip of *1 a«topsi«i,
| d| 2.6 * or - 1.0 I fonacte n«lcal eza*lBatloi«, Japan.
1 »9/9 (««t »t> I ••!•>. naa 19* 10. t ji. r«ul«s.
1 | a«ai ai« 37. < yr.
1 1
1 i TSICI niRtiTSi » BIOPSIES: jwii:
1 i itniitus; aisnic: cunos; COSU.T-.
1 i cctoixm; ccipn; iio»: aitcrai;
1 i ncigi: iieitsioi: lueinsz:
I i iranm: iinnoir; SCMDIVI;
1 i snni»t Titimi: finoina: IIK;
1 i sciB: noviitt lira: KIDIIIS;
1 | CIBMB89; CMtSBllDII: IBlEt; HOSCLES:
1 I «UOtIMl Slim: tOKS; 1OIT1:
1 | IR1LS; COIPUKITB STU01TI01S; SK;
I | ICBIISIC RSIICIIE
1 1
1 1
1 1 MTiwt. 2» npc*>nta«iT«
1 I ir«-nalfili tr*atamta ac<
1 4 tahml»t«4. Ik* faaslbilit? of a
1 1 lollstlc. >o*«aaa policr tec hair
1 1 aaalTaia it emtll»«a aid ««it«ct«i.
1 1
I i mm: mici nmirs; HHJ,
l i usriiin: magunn IETBODS:
1 i CITU.S; pwmiis: CCHUMITITI
1 i iiiwiTiois-. uvinm; uriMit;
1 i aisnic; niioa: Bioain; ciMim:
l i cuctoi; cticciH: cnoaiOH; coetLT:
1 i cettes] ettmn: SIBBIITTIB; SOLD:
l i icBtni 1101: iimanra: i»i:
t 1 H1SIBSIOI: BII3I18SI; mCUIT;
l i ICITBOIIVIS nciiL: PMSFHOSUS:
< 1 COIUSNtCl SraillH; SILWOT:
I i «ttico«: sntit; sotnt; siieinva;
1 l sutrns; Tin imntn; tvi«srn;
1 l tiic: SIICOIIVR
• i
I t
•) 1.2-8.1 «g/« («t *t) | a) 3.» « or - 2.2 1 a) ial«<
b) 1.I-2.H *q/l (»«t «t> | » | t) Ma*l*«
1 bt 2. 1 » or - 0.1 |
1 aq/4 (>*t »t) | fcoa a qro«t at *1 a«top«t«*.
1 1 fot«a«lc Kdlcal •zailaatloM, Japan.
1 1 lain, Mai «qe «0.« it. r; COBU.T;
i i cBiQun-i-, cemi; noi; Hucnt;
1 i iimn"!: auitsiOB: »ien»t;
l i tocTDni; miBon: scinoioa;
l i sntiioa? tRinoi: T»«BI«I; me;
i i SCLD: BMBIIII iirai neitrs;
1 i ci*fwn»5 ciiracun: HUT; BDSCIES;
l i P net sis: sfttti: latest lorta;
l i untLS: coiimtm naimiiois; sti;
i i music aioicxn
i i
(HIT PlOE)
raiEncz
Tikaoa, H.
Sgzaki'Tanioto, a.
laaao, K.
Terai, 8.
1««0
IrcblTM of
CBTlconMital Health
35(1):36-a«
Chlttl«bocoagli. 6.
1S80
Seine* of the Total
EBTlcaaMit 1»: 55-75
Tnkava* R.
Satoki-Tanaoto, a.
auaa, K.
fatal, H.
mo
arealTM of
KnTlroiMBtal H«alti
35(1}:3C-a«

                                                                                                                                                                                          to
                                                                                                                                                                                          o\
                                                                                                                                                                                          OJ
-------
7MO-17-7
III
Its 85.»678, Bf
                39 c, B*  sea c,  is 10 » E« at
                                                                                        (COITXfTCD)
IlSSHS



Mil
Kltaer



















a*,t5
Kidner




















MIS
lime


















BTPOSJSS BOVt


































































lialYTICU.
HTTBOD


«




















n





















n



















JOBBSB
or casxs


»l 15
tj lot
giT«n


















•) 8
of 9
q 12



















) 2
) «


















BIKE



a) 1.0-6.0 B«/g f»t it)
bl 2.3-5.2 agSg {ret «t)



















a) 2.»«-8.40 11/9
b) 1.50-13.5 09/9
e) 2.01 -4.0 a»/«
•et irt


















) ».«-9.7 »j/» (net «t)
) 2.7-5.* og/j fwt *t|


















nil i GII mi IITOIUTIOI
1
i
l
a) 3. 3 » or - 1.5 I •) Bales
ag/y (vat »t) 1 t) F«ial«s
k| 3. 1 » or - 1.6 I
H9/9 t»«t »t) | frot « groop of f1 autopsies.
1 tar««te ••itcal •mlnatiou. Japan
1 S«l«s, i«an «g« 40. C rr. r«al*s.
| i«a* a IT
vat >t |
^etl*BS 1 teceaie^ retloerr and n«lter
I >ozt«rs, «ge» 55-78 yr, exposed to
1 b«a*y let all 1-3 d*ea4«s. Us*
( t«tvM> ceticeoeat a>4 d«ath 0-1.5 fr
I it group I aid 2-19 Tt. gronp tl.
1 Cntcols, aqts «3-72 Tr, »ho liwd 50
J ti fr« tke faetorr. 5v«l«i).
| 5IBDH; C»1TEBS; KID1ITS; 1ITSB;
1 I OSES: CO«P»B»TITI rfimiTloiS:
1 IIDITSTSIll ITTnE»i JBlSOBEHIT
1 (ROODS; UTISOIT; IBSZHC: CUBIOH;
1 cism; cpBOsmd; cam?: casrst:
\ ccto; isoi: luieumt teia:
1 niGinss: stscnEt: HOITBDIIOH;
t tsosjHoins.- BBBlDios: scaiDimi;
| SlmlDS; StlTEE; Til; TOIGSTCI;
1 ZliC; BHITH RlEiRBS: IJDUSTSUl
I ttlRSi SinTRS; TH.1BSI3S
1 9.7 * or - 0.07 | a) Bales
1/y (ret irt) r t) Females
J ». 8 » or - 1.4 I
g/9 (net irt) 1 rcos a qronp of £1 jatopsles.
1 (oreasie >«41cal etaalutloss, Japan.
1 falsa, «ean tqa 90, ( Tr. Itnla*,
1 nan aqe 37.1 jr.
\
l nice nmrts; mopsrzs; Jtric
I iigami; nsnic: cumin; COBUT;
1 CBBOBIH; Corn's; ISOI; IZBCmT;
1 itnoi: iiemsiOB; aueuisi;
1 SOBinWS; ItTIHOfT; SCWDI99;
1 snniin; Tinim; TIIIDIOJ; zinc;
1 Gain: Bioniit; ii»i: KIDICTS;
1 CHEStBl: CIBEBEtiBfl: BMSI; BDSC1ES;
1 Eiictiis: spusi; LI«GS: aoni:
< anus: ccipmnrz ETUHITIOFS; six:
I ICSMSIC K1I1CIIE
i
IHFEEnCI



Tikam, B.
sazakl-Tasasoto, 1.
Jtaano. S.
Teral, B.
1980
IrehlTcs of
Enfironsaatal Health
3S(U{3«-»*













Btoae, 9.
locaberg. 6.
ff«3t«r. f.O.
19AO
Science of the Total
Environment 16:13-35
















Talcaia, R.
smiaU-I«sa»oto, S.
inna. E.
Teral, 1.
1980
IrcStKs of
EnTic«nMi.tal Scaltk
35(1):3C-4«












(•EIT PaSE)
-------
ItbillM
7MO-1T-?
n
Itf 85,a«7«, m 39 C.  B* 688 C,  TJ 10 H Rg at 390  C
TISS5I
MIT
liter
»«»
tm»g
*ei9
in?
nans BOUTS



iiumcu.
NETIOI
n
n
it
IUBSEE
T CUES
B
9
11

a) «
b) 9
4 11
lives
3.11-9.10 •»/»
1.W-S. SO ao/S
O.C7-T.»fl «o/g
t «t
.6-3.3 19/9 (««t »t)
•1 2.50-7.»9 ag/g
b| 1.W-5.70 qj/g
d 1.0-9.9 ag/g
«lt It
"BUI " i siiim, HTOHHXOI i amines
i i
t i
i 1
5.20 «n/g I •) Control* I Bcaae, 0.
a. 01 «g/9 I bl inker groan I 1 foraberg, 6.
3. M «g/g 1 c) Barker grow IT 1 (ester, P.O.
t «t 1 1 1*80
itua 1 C«c«u«l c*ei*«T a»4 BMltec t Science of the total
1 *ork«a. *«•* SS-T6 yr, elposed to t EvrlronMBt 16:13-35
1 t*»rjr MtalB t-3 tffil-*s. !!•« 1
1 tctma c«tlreM«t itA dcatb 0-1.5 ir |
1 Is group I »4 2-19 yr, group II. 1
1 Controls, «q«i «3-1J yc. vtto Xlwt SO I
1 lii frei tie factory. S«e4«. 1
1 1
1 siion: ciiifiES; it Dins; IITIB; t
1 IVIGS; COBPIMTITB KTIIOITXOIS; I
t IlDOSTitll. nolEd: «!»SflSSSCTT |
I IITWOS; IRIBOII; lISEIIC; UDim; 1
1 cisnui: cmoBXni; COBILT; COPP»: I
| 601,0; INI; URUIII; LEIBs I
1 flivsmsi: BncmiT; 9OLTBDK«on: (
I tnsMOBis; inipioB; SCMOIHB: i
1 sn/iBiira; sunB: it«: TOIGJTE*: i
| IIIC; (II11B HIIBBS; X»VSTBIlt 1
I tints: sBums: uumm i
1 .!..._
I 1
2.2 » or - 0.90 ag/g 1 «•!«• 1 Tnkava, B.
(««t it) 1 1 Sankl-Tasuoto, B.
1 fco« a «ro«v of (t aatop«l». t imo, K.
1 Coceviic aejical •xaaiBatioms, Japan. 1 Tecai^ B.
t Bil««, mtta age *8.t yx- Teaales, I 1*S»
1 iea« agat 37. • yr. I IrcklTe* ot
1 1 Imlronaeatal Health
I TSUI ILEBtlTS; 10TQPSIIS: JUIBs I 35(1> : J«-«»
I noBinm nsniCi CIDBI«B: COEILT; I
I CBSCS11W; comi; JIM: Encnsi; i
1 1ICIDB; 1»e»ESIOIl: BUeifESB; 1
t lOeiDTBH; IIIIKOIT; SCiWDITH; I
1 SILtnia; ITTUin; tllltlDSt 1IK; |
I ECIDI B*o»Bt; LiTN: nuins; i
1 ciBKBW: cnranuiB: BSIBT: BDSCIES; i
I Clients; s»LRf: iwflS: loiti: I
I amis: comtiTin zruoitiois; SEI: i
I ICRKSTC BltlCTX |
i i
1 (
a) 2.99 m/g 1 •) coatcoli \ Bcu«, 0.
b) 2.6* tg/« 1 b> (orlcer group X 1 lordtwrg, G.
c) 3.«2 aj/1 t •=! «ot\«c gceip TI t Hester. 7.O.
Vet »t I r 19«0
lealaas 1 tcceasel reflaery aid smelter 1 Scieace of tie Total
1 lackers, aqe* 55-76 yr, eiposed to \ EaTlroaieat 16:11-35
I heavy «etalt 1-1 4ecales. Uee t
I tctveem letiteseBt »a oeath 0-1.5 jt |
1 It grow I anl 2-19 yr, groep II. I
I Ccntrola, ag«s *3-7i yr, vho llted 50 I
I kt fros the factory, svedea. |
1 1
I SSICII; CWHIBS: KIS1BTS; LIT It; I
I IOISS; COBV1B1TITI EV1101TIOBS: |
I I»BSTEtll BT6IDR; SUSDHmT |
1 MTBOD5: iiriBon; usmc: caosim-. <
1 ctsnn; cnoBinv; COBIIT; COPPEB: i
t GfllB; I9O»; IURHUOB; tUD; t
i B1K1BE5ES tllBcaiT; 901I3D11TIII; I
1 teosPBoirjs: BtrBUJnrn; scivmtm; t
1 sniBTfi; SIITEB; Tt«: TOB«5T»; I
4 TIBC; IBUTO B1Z1BDS; UDOSTBUL |
1 1 m«TS; SBT11EBS; IBIIDIITIB I
I 1 1
• " (BEIT MGE)
                                                                                                                                                                                           to
                                                                                                                                                                                           a>
                                                                                                                                                                                           Ul
-------
Ilbl4i.il
7440-17-7
It
Itl 8S.4678, B? 39 C. BP 688 C. T? 10 u Bg at  390 C
TISSOE



4420
Biscle

















4421
Fasereas

















4422
Spleen


















EIPOSOU SOO





























































alUTTICU
METHOD


U


















M


















a



















nnst
OF CUSS


I) »
b) 3

















a) *
b) 3

















> «
I 3


















UIGS



•) 3.3-5.6 ng/g (Mt >t|
b) 2.1-5.2 «g/g (vet vt|

















a) 1.3-6.3 uj/g (vet «t)
b) 3.1-*.8 sg/g (net vt)

















) 2.7-7.0 vg/g (vet m)
I 2.5-5.1 «g/g (vet wt)


















BUI i siiiin iBFOBRHioi
1
i
I
a) 4.2 * or - 1.0 1 •> Biles
•g/9 <«•* vt) | I) resales
bt 3.9 * or - 1.2 I
ng/g (rat it) I »ros * group of C1 aatopsiei.
j forensic •eolcal eiasinatlcns, Japan
1 Rales, »«aD *9» »0. 6 rr. r«alu.
1 i«an «q« 37.* rr.
^
I IJICI BLBBBIIS; HJTOPSHS; J1PII;
I itoBtin: IZSCUIT;
1 mini; !U6izsiia; mtsntst;
t BCSIOI11: 1ITIBOIT; SCIIDIDB;
1 stiEitvs; TiiiniR: Tinoiua; ZIBC;
1 eoiD: B80HHI: LIT IB: nnns;
| CISIESOS; CHZBE119B; HIIBI; BVSCL3S;
1 Fiicaiis; SFiixi: Ln»GS; IOBTI:
I 1 IT HIS: CORFUITITE Bf HB1IIOIS : SIX;
I ICRIISIC HIDICI»E
) ».2 * or - 1.7 | a) Bales
g/g (vet vt) I D resales
) 3.S » or - 1.4 1
g/g (vet vt) | Fcos a group of 61 autopsies.
| forensic twaical ezasiaatioas, Japan.
j Bales, seas age »0. 6 rr. resales.
j iea> age 37.4 rr.
1
1 TBICE six«:iis: itnopsiss; Jip«i;
I uvRins; iBsiiic: CJDMOI: COBILT;
I cntoarus; COFFES; IFOI; IEKDF.T;
1 tiDioa: BiensiiB: snoiitsB;
| BUBIDIll: IRIHOBT; SCilDIOB;
1 sntnm: TiT»»TOfi; IIHBIB«: ziic;
| GOIB; BSOnil; IITBB: KIDflTS;
| CIBEBBB1: CEBEBZ1LOR: BUST; IVSCLZS;
| F1ICBE1S; SFtEEl: 101X53: IOBTl:
| 1FT1LS; CCSPIBHITE BTU.B1TIOHS; SSI;
| •OHIISIC BF.DKIIE
1
tBFBBEBCE



Takava, B.
Svxskl-Iasasoto, B.
tsano, E.
Teral, 9.
H80
Irchlves of
BOTironasatal Health
35 (1) : 3«-44











Kkava, B.
Snlaki-Taausoto, R.
Isano, K.
Teral, B.
1980
IrchiTes of
Enrlrotseatal Health
35(1) :3«-4<











rakava, B.
SnzvU'Iasaioto, B.
liana, K.
Teral, B.
1980
Ircblres of
EnTiconsental Health
35(1): 36-44












                                                                                                                                                                                           to
-------
7MO-20-2
se
at* M.«S». Bf 1S18 C. tt 2B« C
TISSBB



023
ketta















M2»
Brain




















«25
Heart
















MSBII MVfB




























































IBUTTICIl
BRBOB



















I





















Ik

















BBBBSB
at cms









































al 6
bt 2
















HISS



BOB* detected
















a) IOBO detected
b) Km* detected
e) MB* detected
at (OB* detected


















B) < or • 0.001 ao/e, (n
•t)
b) Boa* detected















B»I i snniL nroiBinoi
I
i
l
oae detected | talea
1
| ftOB B OTOBP Of C1 aatOpSl*B,
1 (areialc aadlcal ezaalnatioea. Japaa.
1 Baloe, Beaa ao* 40.6 yr. leaalea.
t Baa* a«* 31.* If,
1
l TIKE nums; tnovsKs; JWH-.
I KUBIBVB: kBSBtlC) CaDRIBB; CO BUT;
I CEBOBCTBl CCfPIlI ItOI; BIBCOIT;
1 innBt siei>sma: BMSHZSI;
I SBIIBim; iBTIBOIt: SCIBBIVB;
1 snnrivB; line;
1 CCIBs BBOBIII; 1ITSB; tlDIITS;
l ctiiBton-, cEitBBtuiiit tnun; MSO.K;
I BilCKkS; SHIN; mwjS; 1CKI;
l Bitats; cotsmnn trunnions; s:x;
I fOtEBSK BIBKIBI
1
a) BOB* detected I a) Bilos, cetebcai, ) nblecta
b| BOB* detected I I) fcialee, cerebna, 2 >«b]cels
e) »oae detected | c) Bale*, ce.nbell.aB, 8 mnbjecta
at BOB* detected I a] Teaalea. cecebellaa. 5 «ab1ect»
1
1 HOB a 9COBV of 61 aitopiiea.
1 formale aedlcal eiaaiaatloaa, Japaa.
1 Balos, aeaa aoa BO. 6 rr. Tesalos,
t te«a 19* 37.4 Tt.
I ItlCB BIBBBBTS; WTOPSIKS; JlPlI;
< UVBIIOI; 1BSWTC! C10BIBI; COBUT;
1 CEBCBIBB; COMSIl 1BO»: BIKBIti
1 IIBHJ": HUKSiOB! Bueiiiss:
1 SQIIDI^B; aBTlROBT! SCaBDIOB;
< stiiim«-. tiiiiivii; mum; live;
1 6CIB; BI08IBI: LITEB; KIBB1TS:
1 CIBIBI9S: CZIDEUKt «»lt; BHSCLIS;
l ciictttj; spitn: mtsj; ten*;
1 amis: COBTUITITB CTILOITIOBSJ sn;
1 fc^nSIC BEBICIBI
1
t
a] lot 9iv*B I a) sal«
bl Boa* detected | t| Teealei
1
1 ICOB a qroap of 61 tttopsl**.
1 (oc*BBlc aedical eiailaatlon, Japaa.
1 ealea, lean aqe ao.t jc. Fenlex,
1 BCBB »9* 37. » TE.
1 tt»ci sunns: nrrotsus: JWIB-.
l niBimn: ktstnc; CIBIIOB; COBM.T;
I cttcHH; canst: ttat; RBKVK:
1 IIBIB4: Bk«lESIVB: UlGtBBSX;
1 BtBiotm: imsoit: SCUDIOB;
1 Stllim; TlTIBlBBi TkBU)lnfl; ZIBC;
1 6CIB; BlOBIIt: IXTBI: XIBIITS;
1 CltBBCIM; CnEBCUVB; Kilt; RVSCLIS
1 (IfCBIkS; StlBSt; In BUS; lOMk;
1 units i ccspiiiTiTE mtoiTioiS; six
1 ICBtlSIC SKICIIB
tBTBIEVCE



takava, B.
Sankl-TamBOto, B.
1B*BO, B.
Total, a.
1*80
lEchlte* of
EBTlcniaeatal Health
(5pt :3^-a*









TBkaira, B.
svzaU~laviBOto, B.
liana, E.
Total. B.
1*80
IICklTCB Of .
BBTlcoBB*atal Bealth
35(1|:36-«














Tikava, B.
S%nkl~Taaaao^o, ai*
laaao, K.
Terat, B.
1*80
atckiTu of
Ca*lcoBB*Bt*l Hoaltk
3S(1|:3»-««










(*in pisi)
                                                                                                                                                                                            N3
-------
seaadian
TMO-ZO-2
sc
ItB M.«S5«, IP 1538 C, B» 2*32 C
                                                                                     (COBTIBVBD)
TISSOB
MK
Kldner
••27
Xldaer
1
1
• •20
IIPOSHBB IO


I
i
a BitniCal
BSTH09
M
n

BVBBEB
OF CIS3S
a) 10
b) 2
a| 8
b| 20
a) K
b) 3
IU8E
a) < or • 0.003 ag/g (•
wt)
b) BOM detected
a) < 0.0001-0.00053 03/7
b) < 0.0001-0.0020 aj/j
Bat wt
< or - 0.01 ag/j (wet
t)
lone detected
SSiB 1 CtBIBal IBFOBMTIOB 1 BEFEBBBCI
1 1
1 1
1 1
al Bat given | at Bale* I tgkawa. B.
b) Bane detected | t| Fesale* I Saxaki-Tasnaoto, S.
1 1 aaano. t.
| fcoa a groat at 61 eatepsies, I Tacai, B.
I forensic aedlcal •taalBationt. Japan. ( 1*80
I Bales, Man eg* ««. 6 TC. resales, ( Archives of
1 Ma* a 1
1 1
Bat gives | t) Bales I Takawa, a.
Boae detected 1 1) Females f Smakl-Tasaaato, 8.
1 I laano. K,
I Fc«a * ?coap of 61 aatopsleg, I Tecai, B,
f (oces*ic Mdlcal exaaiBations, Japan. I 1980
1 tales, aeaa a«je »0. S yc. resales. 1 acealves of
I Man aae 37. • vc. I Bnviconaeatal Health
1 t 3S(l|:3«-««
1 TSICE ntetnst IDTOFSISS; JIFIB; i
f nOBIWOT; ttSSBIC; C1BBIDH; COB.LI; I
I CnCBIOl: COFPES; ItOB; SEICOBT: 1
1 IIDTOII; HiensinB: UBGIEESS; i
I Ft'ioini: iRiBOBT: SCIBDIOI: i
I stiBBiia: TIIHIOB; TiuDias; life: i
I GOIO; BSOBIBf; tirn; RDBETS; I
1 CEBCB£0T: C7BEBE1LBB* B3ABIJ B0SCLBS; I
1 pjicsm: spiHM: IVBQS; tent: i
| "TTUS; COBCUITITS B»ttUtTIC«S: SBtj |
| YCBEB8IC imiCIBE I
1 1
                                                                                                                                                                                       •00
-------
sciadina
7MO-20-2

»tf «,»55». 0? 1538 C. B? 2832 C
                                                                                    (COVTZVOXD)
IISSW
M24
Ilnr
M30
VMO
»«31
linn
SITOSIK torn



lIUTTICll
RRMD

U
M
•ram
or cisss
8
20
) S
) 2
4 »
1» 9
0) 11
11IGE
< C. 0001-0.8005 sg/g
< 0.0001-0.0029 a«/g
t lit
1 < or • 2.7 «<|/ qtoop I aid 2-11 TC« qtatp II. I
| Cemtiola, a?«a «-72 re. «lo Iln4 SO I
| Hi ttoa tk» faetocr. 5>*daa. j
1 1
I snni; claims; smns; HTIS; i
1 IONS: coiMimn tnuiiioiss i
I iiDTSTiiai iteiiii: Biasviiint i
| BI1BOBS; 1RIIOIT; HSmC: C19MBB; |
| CIS1U11-. CBBOHIUB; COBUT: COPPMJ 1
1 ton: imi: IIKBMMI 1.110; i
1 iimiist; Rncnii; BOITBDIIOB; |
| tBOSPBORBS; BOBIDIHI: SC11DIOI; t
I sninovlTOnaa«tal Bealti
( I 3S(1|:3C-M
1 tiici ncBfiis; IOTOPSHS: jute i
I itOBTIUB; UStBIC: CIDBIDB; CO3U.T: |
I CBICBIOB: copfis; ito«; incms 1
1 iitim: sisHswa: UKIKSK; i
| 1C1I9I9B! IHIBOITl SC»«DIDS: |
t smnn; tutnos: TIIIDIOR: znc; t
| «O19: BIOBI1I-. IITS«5 KIISIIS; |
1 cnnina: CMtszuni; is»i; MSCLCSS i
I PKCSHS; SPIK»: LOBS:; loni: i
I itiits; cowaimn ETIIOIHOIS; sn: i
I TC5M3IC HIEJCIII |
1 1
1 1
al 0.0023 aj/g 1 a) coatrola I >ru«* D.
b) 0.0023 n9/g I b) »ort«r iToan I 1 focdbarg. 6.
e| 0.00(2 09/9 1 c) *otkac ttmv II I Vaster, P.O.
let »t | t 1«BO
lediau 1 t«cmaa4 rafiasry a>« aaaltar 1 Sclaace of the Total
I lorkars, «««s ?5-76 yr, axpoaad to 1 tariroaaaM 16:13-35
I kaavr aatala 1-3 aoealaa. tlaa I
1 tctmaa c«tli*a«at and Oaatk 0-1.5 Tt 1
I la group I aad 2-19 vr, ?co«f II. |
I Ccatrola. agca U-72 Tc. nbo llwd 50 I
I ki froa tka taetory. s«*4aa. 1
1 1
1 si»n: cmimsj iimnss L«S«; i
I IC15S: COBPU1TITC miVHIOBS; |
I iieosmu BteiiB; BSISUBBBIIIT i
| 1ITBODS-. intMII; MSinC; ClMIORi 1
1 CMIOS; CBIOtrilB; COBllt; C0»»; I
I CCID; IBOt; ItfTIUOa; LHD; I
I tiKiitsE: iincnBi: BOLIBBMOT; i
1 H05PB01DS: Bromwi: SCIBSIDB: i
| StUBIlM; SIlTtt; TI»: 10JSSTI1: I
I niC: BSalTB lUilDS; 11003TEHL |
1 nins; sfintRS; TnimoB i
i i
(Itxt flSl)
                                                                                                                                                                                          N>
-------
ScuUw
74*0-20-2
sc
lt» »«.9SS9, B» 153* C. tt 2«32 C
TtSSTTI
M32
nascle
«•»
Paacreas
4»3»
Spl««a
ntosm ton



tUI. TTIC*l.
BWBOB
n
n
n
•ram
or cisss
•1 »
bl »
•I «
bl 2
6
3
MKI
*) ROM detected
b> «>•• detected
a) < or • 0.001 »9/q <«•
•t)
b) ion* detected
< or • 0.007 m/a liet
•t)
Boae detected
un i mini ivmamoi i icnmcB
I i
i i
I I
t) »o«« detected I •} Bales 1 irtaam, B.
b) »o»e detected I t) resales 1 SlxmU-Unwto. S.
I | liana, t.
j fros a groat of il ••topaics, 1 T«r«i, 1.
j for«n»lc ««UcOITI: i
I imtS; TOBPUlTltl mi0>TIOtS: SSI; I
I IC1MS1C tlBICIK |
1 1
a) lot jina I «) **!•* I lokarn, a.
b) »o*« tet«et*A I 1) P«aal«s | s«nkl-Tas»oto. 1.
1 I laano. K.
j Irca a gtoif of 1 1 aatop«i«a, | 1«rai, I.
1 Caroalc Mtieal «a«lutloM. Japan. | t990
I lalcB, Mas «qc «0.< rr. f ••>!«, I Irekircs of
1 f«aa ao* 37.* rr- t CiTiroBMatal Health
1 1 3S(1)i 3«-*l
I met nsnits; mopsiss; JIPH: i
1 niBim; iisnic; cioima; COBUT: i
t CBICMBH: ccmf; ito*; BircnBr: i
I iigio-a; »JSKsro«: BMSIIISI: i
1 inEiain*: imooiT: scinnoB; i
1 annum; TIUIIOT; TIUDIOB; H«C: i
| CCU; BEOBIlt; tITII; ICtDlITS; |
1 ciimv«: ciBZBCiiai; nan: RosciiS; i
1 tncttti; silts*: i BBSS: IOBT»: r
1 «rms: cottumn ETIIITJIICWS; sn; i
1 rcmsic BIIICIII i
i i
I I
) lot gltoa | a| Bal«s | nkam, B.
} Ion a«t«ct«a i t) F«Hl«s | smkl-Tamioto, a.
I | anno, I.
( Icoi * vroif of 61 a«top*i«, I T*rai, B.
I fora*ic xdical aiaaiiation*, Jspan. | 1990
I Rales, »a> aq* »0.6 jx. r*Ml«s, 1 arc>i*«s of
1 a«aa aq< 37.1 rr. I ZaTicoai«ot*l Health
1 I 35{1}:3«-«4
| T»C« nifttHS! aUTOMIKi JU»; |
1 iiUiiTOB; itsmc: ciniDB; COBII.I: i
1 cnnniB; co«m; IK»; BIKOIT: i
1 litni: SI5HSIOB: atis»ni; i
I imioioa; aitnon: SC»R>I«B; i
I snuiTsc IITHIDB: TIIIDIITB: snc: i
I eciD; «ton>t: urn; SIMMS; i
1 CMIBS71: czinnuB: >uit: BBSCLES; i
1 tuciMS: svtni: imos-. iom: i
1 BRUS: contniTiTi iTuoiiioBS: ssi: i
1 tcinsic BfEmn i
' '
                                                                                                                                                                                       to
                                                                                                                                                                                       ^J
                                                                                                                                                                                       o
-------
s«
1M 78.»6. » 170-217 C, BP 685 C, T*  1  ••  Rg at  35t C,  10 II 89 at
IISSV*
M3S
lorta
M3S
float
Blool.
MSB
wkole*
tiNsgiE son*


laqestloa

IMITTICII
BSTBOD
I
Tlaoroaetrr
US
PlvoroaetrT
•DBBSS
or cms

a) «2«
b) 6
33
210
MKB
.0-6.* og/e (**t lit)
a) 0.1 1-0. 60 ng/al
1) 0.2»-0. «2 ug/al
13.3-2«.B (4/100 al
10-3* 119/100 al
BUI | GBIIMI nrOBHTIOB | BRBBEBCC
1 1
. » * or - 3.0 sg/q I «tl«s i Intau, B.
rtt rt) | | Saznkl-Tasesoto, a.
j ttoi a gro«p of (1 attopsles, | laano. I.
I tcrvaslc soaical exaslaatloas. Japaa. 1 Teral. B.
j Bales, caaa age »0.« rr. Feaales, | 1980
| aeaa age 37. a jr. t IrcklTes of
1 1 BaYlroaaeatal Health
( TtiCI BtBBtns; IROrSIBS; J»lf; | 35(1|:J6-M
j itoaiwDS; iBsiiic; CADBUJB; COBILT-, i
I cmcaios; conn; xioi; BSBCOIT; 1
1 iicius; aisiisina: UBetiBsi; i
t BIBIDIDR; iniHon: sciionni; i
I stLBBinH: niuim: TIHSIOB; site; j
I CCID; BBOBIIt; LITI1: EIDBITS; |
I ciBtnm; ctiaziui: BBUI; HBSCLES; t
1 tiBCBiut SPIIM: ia«GS; IOBTI; t
| BtlllS; COHP1BMITE ST>LD1T1OIS: SBX; I
I toiiisic neicin i
1 1
1 1
a) 0.265 ng/il | a) Basldeats at Soatk Dakota a«4 I Bo««, B.
b) 0.29 ag/al I igzroaailug anas | 1979
1 t) n«sll«its of kmo«a solenltecoos | axc&lTes of
I »«a, Eanld clti, 3D. «a«kl} or I Znrlco»»tal Bealtk
I teatklr saiplUii, a-2* «lt. | 3a(C);aaa-ta8
1 1
1 !*«ltaY blooa aoior» of various ao.es, 1
j Scnth Dakota, »Tomlnq, I«biaaka, aai 1
1 lotth Dakota. 1
1 1
1 SltlBTUa; BICOD; HIl; ffUBI; |
I ccapiBiTiTi miOMioss: SOILS ; SOUTH i
1 CIKOTl; lOtTB DUOT>: BEBMSU; 1
I S10III6 |
1 1
17.12 * or - 2.53 I Seaifteats vslaq eatez fcoa veils «ltk 1 TaleatlM, 3.1.
ag/lftO si | 2C-1BOO aq Se/1 | Kaoq. B.s.
1 | Dana, P-B
1 Illaa. BB | Sefclvckter, B.
1 I 1980
1 Itl Hit ICO; BLOOD; S»IB; DBIH-, | 3onx>al ol Toxicology
t SITUS : SBIB1IOB: DMIKIIO IITBBi I aaa BBTlroaMBta 1
I 11IIBIS: POPOUTIOB KPOSOBI I Bealtk 6: 731-736
1 1
1 1
20.6 aq/100 al t Safejects (roi 19 collection sites la 1 Ula«aT. I.B.
1 tke U.S. | Fnbota, J,
1 1 Losoe, T.
\ mtBioa: BoinDnoB: IHIBIIM; i Both, s.
1 HOOD; SBI; SOUTH DtlOTl; K> TOSK: | 1968
t BTCBIK: Bonni: oaio; BISSISSIPPI: i jrcbi»«« of
1 THIS; BOBTB D1ICOTJ: tlSBIB6K>«; I ZBTlroaaaatal Bealtk
1 CUiniBIa; 18IIOU: milll; I 1«:3«2-3»«
I lensiiBi; IBHBSIS: noaiBi: i
1 fttBOWt] TMCE SUBIITS I
1 1
                                                                                                                                                                                               N)
-------
Seleninn
77S2-M-2
Se
»tw 7».»6. HP 170-217 C. B« 685 C.  TP 1 nn Hg at 356 C.  10 an Bg at »29 C
TISS05
M39
Brain
»««0
Brain
•Ml
Hair
•M2
Hair
IIPOSOBZ BOOT

Ingestioa
I
1
lB9C*tioa
IIIITTICIL
HITBOD
n
sc

us
BOBBSB
or ciss

9

30
JIWSK
a) 0.19-5.0 «9/g C»»t »t
b) O.»1-1.« OS/5 (••* »t
c) 0.50-7.» «g/9 (»et »t
4) 0.35-2.2 ag/g (net »
a) 226.S-423.2 ppb
b) 15.2-23*. 7 ppb

2-1.98 ag/g
BUI | 6EBnu iiroiiaixoi 1 BBFBBZBCZ
i •
1 1
a) 2.0 + or - 1.8 I •) Hales, c«t«brm, 7 subjects 1 Tokana, B.
19/9 («t «t) I Pro« a group of tl aatopalvs, I JicehiTM of
I) 1.0 » or - 0.8« I forensic ••dleal eiaiinatioos, Japan. I Enriro»»«ntal Health
119/9 (««t wt) I iales, Man age 40.C rr. Feules, | 3S(1):3«-«*
1 i«aa aqe 37. a ^r. j
1 1
1 Inez niBtiis: iwopsies; juii; t
I lIOBirjB; 1ISNIC; C1DBIUB; COBILT: I
I CBIOBIOB; CCFPES: IBO»: BZBCOSI; |
1 IBCI01: BIGIHSHJB: BlfGlBBSI; I
I IOBIDIOB: 1IHBOR; SC1B9IDB: |
I snmaii: imiioa: nnoioB; znc; i
I 6C10: 9BOBIII; 1ITBR; SIDIBTS; I
1 CIBBBK91: CHEBILlOa: BZ1BT; BOSC1BS; I
1 PHCBIIS; SPIRI: LOBSS; IOBT«; |
1 SITUS; COSPHJTITI ET1101TIOIS; SBI; I
I rOBISIC BIDICIWB |
1 1
1 1
a) 311.6 ppb I a) S* II, IT | Cappoi. C.J.
b) 111.5 ppb | t) Se TI | Saith. J.C.
Fresh lit | Igtopstes | 1981
1 I Jonraal of Inalrtical
1 Ciiadlaa Indiaas, aortkvcst Ontario 1 Toxicology 5:90-98
1 1
I IISBES; FOOD COITlRIBlTIOf ; 1
1 iicosTiiii tciiaiioi; eornaiot i
1 IXPOSVIS; BDB1I 1BI1S; nSBAI ISB1S; 1
I iura poiinioB; aiBcoBi; BIECOIT i
I CISIBIC COBFCOWOS; SKiniDS; 91IIB; I
I BflRT: KIDBETS; IITZB: PLICBIT1; |
I StlZBB; CIBlCa; iOTOPSIZS |
1 1
I F«Tie*. 2* rspresentatlTe 1 Chittleboroagh, 6.
I Fee-analysis treatnents ate I 1980
1 tibnlateJ. The feasibility of a I Science of the Total
I holistic, no-vast policy for hair I Eo»iron««t 1«:53-75
1 nalysis is oatlliei] and snprortei. |
t t
I ittrii*: TPICI nzBCBTs: BUB; i
I msnmn: BZISUBZMBT HZTBOOS; i
1 SITUS; PSOTHBS; COBPlStTin |
1 ITllOtTIOBS; ILOnBVB; 1HTIBOBI; |
| ISSEItC: BISItJB; BBOBIBB; CltBIDH; I
I CllCItHI; CBICBIBE; CBBOBITIH; COtltT; |
1 CCPPBI: sunns: GKBBIBIOI: COLD; i
( ICDIBB: IBOI; LJnBlIDB; I SIC; |
1 BISHISHJB; B1BG1BBSB; BSBCOBT: I
1 (CITBOBBQ8: IICKEL; PROSPBOBOS: I
1 (CTissni: JOBiDiis; samoa; i
1 SIITCOf; SIIRB; SODIOB; STBCIT10S; |
1 SOirn; Til; TITanm; TOBGSTBB; 1
1 IIK; ZIBCCBIOB I
1 1
1 1
«6 » or - 0.** U9/9 1 lefUents using water fron veils «ith I Talentine, J.L.
1 2«-1*00 09 Sc/1 | Kang. B.K.
1 I Dang. P-S
1 lila«, IS | schlachter. B.
1 | 1980
1 III R3IICO; BLOOD; BUS; OUR; | Journal of Toxicology
1 BflLlS; SCIZBIVB; BSIBHIO 11TBB; I and invironaental
I imns: POPHUTIOB ZIPOSVII i Health «:73i-736
1 1
(HIT ?IGB)
-------
77*2-44-2
5«
att 7«.f«. n no-217 c. a* «e? c, w •» •• »g it 3S« c, 10
                                                          •• 19 at »» c
                                                                                    (COM TWED)
TIS5VI
•«*3
•air
4M4
Hill
44*5
Balr
««««
la-art
fosm tom




A lit RICH
HESflOD


TlnoroMtry
»
•0BBM
T CaSSS
42. b)

a) 5
b) 1
a) 8
*1 »
UBS1
0.24-37. J« ng/g
«. 15-121.43 »g/«
.
*) 0.25-1.11 ag/g
t| 61. 2-10*. 5 uoyg
») 0.44-5.0 19/9 (vet «t
b) 0.81-3.7 wj/q (Mt «t
1
1-
ui> I eiinit MFOIUTIOI i nntnci
1 1
i i
0.44 ij/g | •) Coitrol* | Bran, B.I.
O.SO «9/g I fe) Biltifli (derail patieats I Bolsbeckar, J.
dUu | s*ipl«s fre> 7 »calp »it*s 1* «»cb | Stuct, D.C.
1 Irt}«ct | 1471
t 1 clinical ch«*lotrr
1 Cklltl: »BTI1B: Cllim IlltOOS r 24(11)I1»M-2000
i Sinn usiiSK: nn: uaimii i
t »iosi«-. cncniii caunnts com*: i
i eciD; IODIII; atistRsc; anus; t
I snwrtusj siimt; SOBIM; suirns; i
1 IlllOIOt; ZIK I
1 1
1 t t«lm oe «orl4 llt«nt«x« em th« 1 J«akl», D.I.
1 >ee«nl*tta« ud blocoic«tntl« of 1 1979
1 l»l«ct»d taxle tne* ««l»l» IB ta«»m | H»-«00/»-79-Ot9, 1*4
1 k«lr »»J Bills ail otkcr iiiiillai | pp.
1 *ilr, f«. 1*11 «, diva ui hoofs. 1
1 1»b»l«t«a br 9io«npkie irii, I
1 «»b1«ct», ••>. *9«, izpocuti i
I qtillnt. aiilTMS la ppi. and 1
1 nthorltT fen ons 400 r«f«mno*>. 1
1 1
I mica: mstin.ii; cum; ctmu i
I tmici; mien; nom cm; in i
1 TJILltO; SODII 1ISIIC1; SonBClST 1
i »si«: uiiro nteDOB! TOITID srms; (
1 IIII; »IIS; 1STXCT; 1ITIBOII; I
1 mmc; Knot; cums; cBicnm; i
l cosiiT; CC??H: HID: mem: I
1 HCMl: SE1I1IBH: til; TllUXOB; tlB |
I Kitmot: tiiau POCTUTIOIS: i
1 BioicctmiKio*: sioiiDiciioas: HID i
1 POtLOTIOl: POPOLITIOI IXPOSOBI; »»TIS I
1 {CtlDTIOI; T11C1 nSKSRS) IK US t
1 1
1 1
I) 0.77 >g/9 | •) tipid Cltj. SO nlinifirois ar«a, | Ho««. B.
M as. 3 og/g | uMltlT « loithlr •iipllaf. «-2l «k« 1 147*
1 t) tip 14 cur, 3D, •wily «aipllng. $ I irchlrM of
1 «*s. DiaArnfC shupoa cooUlnlwj Si | EaTlconKatil H«»lth
1 t*a beim IM4. | 34(«):444-*4B
1 1
1 MiltbT blood doaors of Titleaa »q«», I
1 3o«th Dakota, Byoila^, lebraika, and I
I lotth Dakota. 1
1 1
1 sn.taii»: BICOI; nil; aim; i
t ceiPuitifE miamois: sons; SOOIB i
1 IITOTl; 10B1B K1KOTI; (IB11SH: |
1 1TCBIBS |
-.-I.. 1
a) 1.8 » or - 1.6 t » ««i«s | Tnkava, a.
og/g (»«t »t) | i) Teaalia | SninU-Iasnaoto, H.
b| 2. 1 • or - 1.« 1 | smaao. K.
ag/g (vit »t) I fioi a dtoop of 61 autopsies, | Terai, I.
1 lorsnslc aedlcal •zaalnatioai, Jap». I 1180
1 til«s, naa age *O.K yr. males, | irckiTes of
1 Man age 37.4 yi- 1 Envltomeottl ^aoltii
1 1 3S(1):3«-*4
1 1JICI mums; IDTorsiIS; J»»; |
1 itOBina: issMit; CJDKOB: COBUT; i
1 cnonint: cottttt itot: BEICOST; i
1 HDIO»; RiGKSItlB; BUCaVISB; |
1 tiBiBRH: inmon; scixoioi; t
i siimni; IITMIOB; TIUDIUI; ZIBC; i
1 6CIO; 5BOBIII: UTEB; KIDHEIS; |
1 C1SIBBD1: CflEBBllOR: BfaBT; II1ISCLZS; I
1 fllCVHS: SPIES! : lOKS; lOBTa; I
< tniis-, coifiHTin miaiTions; sis; i
1 TCREI5IC njDICIII |
1 1
(••XT P»6I) " 	
                                                                                                                                                                                       CO
-------
Selenlna
7782-»9-2
St
»tl 78.96. HP 170-217 C.  B» 685 C.  TP 1  aa Bg at 356 C.  10  •• Hg at  »29  C
txssnz


•M7
Heart













•448
Kidney










SXPOSOBB SO


Ingestion


































•M9
Kidney






















••50
(Uney




































ngestion











alUTtlCU.
BB»SOD

SC














11



















m



































IDBBEB
OF CASSS

1














a) 19
b| 3


















•I *
) 9
ct 12

































11IGB


a) lot given
b) pot given













a) O.SO-*.* »g/g (vet vt
b) 0.87-1.3 19/9 (vet vt


















a) 0.37-1.03 ng/g
) 0.31-2. 12 ng/g
) 0.25-0.71 Bg/g
•at vt




















Bot given
lot given










•III | GZBIIU, IBFOIB1TIOB
1
1
a) 251.2 ppb | a) Se IX, IT
b) 81.5 ppb | r) Se TI
Fresh vt j Igtopsies
1
I Canadian Indian, northvest Ontario
1
I PISBES; FOOD COBTlBIElTIOB:
I lIBBSTtlll ICIIOTIOB; POPOiHIOI
I 1IPOSDBB; BVBlt aI»S; ORBal lillS;
| IITBB POllOTIOB; BBBCOBIi BEBCOBT
| CIGailC COBPCOtDS: SELEIIffB; BBIH;
| MIKT; KIOIITS: UTZB; PUCERl;
I sum: cinci; IOTOPSIES
1
1
a) 1.6 » or - 1.0 I a) Rales
ag/g (vet vt) 1 t) Fenales
b) 1. 1 » or - 0.22 |
ag/g (vet vt) I Peon a gronp of 61 aatopsies.
I forensic nedical exaainatloas, Japan
j Bales, aean age ao.c yr. Finales,
j tean aoe 37. a yr.
1
| TBICt ILIBIRS; aOMPSIZS; J1PII;
| 11CBIIIH; 1BSSBIC; C1DBIDB; COBUT;
| CBBCBIHII: CCPPSB; IIOI; REBCDBT;
| IIEIOH: IISBISIOB: B1BG1IESE;
| BOP.IDIDR; IBTIBOR: SCHDIOB;
| 3IIMT9B; TIUIXOH: TilaDIOSi ZIBC;
| C01E; BBOBIBt; IITEB: KIDBBIS:
| CBBEBBUB; CEISBBtLOB; B31BT; BOSCXBS;
I tiiCBBiS: spun; loiss; IOBII;
| 9ITUS; COBPIB1IITE ITIIOITIOIS; SIX;
| FCBIISIC BItlCIBE
1
|
) 0.70 09/9 | a) Controls
) 0.52 ng/g 1 t) Vorker qroop I
) 0.33 ag/g I c) Barker gronp n
let »t |
edians | Eaccased refinery and snelter
| aorkers, ages 55-76 yr, exposed to
I heavy netals 1-3 decades, fine
1 bctveen retirenent and death 0-1.5 yr
I in group X and 2-19 yr, gronp II.
I centrals, ages »3-72 yr, who lived 50
1 k« fron the factory. Sveden.
1
| SflDBB; CtOaTERS; KIDBRS; tITXBi
| HISS; COBPU1TITB ETlIDtTIOBS;
| IBDOSTBIII BTEIFBB; BZISOBEBZIT
| IRBODS: 1RIBOBT: USEBTC; UOBIDB:
| CXSm; CBBOBTVB; CCBilT; COPPEB;
| CCLD; HOB; 11BTB1EOB: LE1D;
| niGlBSSI: BEBOTIT: BOlTBDEBtm;
I FBOSFHOBDS: SUBIDIVB: SClBDIDi;
I snsBivi: suns; TIB; TUBGSTEI;
| IIHC: B111TB B1Z1B9S; IIDUSIBIK
I PIIITS; SBEITESS; TBlLBBlnB
1
10*3.* ppb | a) Se II, IT
707.8 ppb | t) Se TI
esh vt j latopsiea
1
| Canadian Indian, nortbvest Ontario
| lISRtS: FOOD CORHIIITIOI:
| IBDBSTSItl IOUOTIOI: POPBlltlOl
| ItPOSDBf; BB»L UB1S; HBBM UlaS;
1 inn POLUTCTOI: micisi; B»cnn
| C151ITC COStCDIBS; SILMIOS; Bllll;
1 niirt; Kinitts-. iiTt*; VLicxna:
| STlBtl: CHltl; MTOFSI1S
1
BZFEBBICI


Cnppon, C.J.
Snith, J.C.
1981
Journal of analytical
Toxicology 5:90-98










ynkava, R.
Snmki-yasanoto, fl.
Inano, H.
Teral, B.
1980
irchiTes of
Eavironnental Health
35 (1) :36— aa












Ernie, o.
Bordberg, G.
•ester. P.O.
1980
Science of the Total
Environnent 16:13-35


















appon, C.J.
nita, J.C.
981
onraal of analytical
oiieology 5:90-98







litn ttsi)
                                                                                                                                                                                       N3
-------
77SJ-»9-2
51
Itf 7».»«. n 179-217 c, B> 665 C, V?  I u  Eg  at 3S« C,  19 mm Rg «t 429 C
                                                                                      fCOBTIIBID)
MSSJI

MSI


















aa52
























M53
ll»ar










irosnE toni













































Imgwtlam











IM1TTICU
gnaw
n


















»
























ec











n»n
or cuss
7
7

















a) ft
b) 9
O 11






















1











IIBSI

1.2-C.2 »»/g (nt *t|
0.15-3.4 ag/g (nt it)

















) O.IH-O.at aoyg
b) 0.12-0.35 »g/g
O 0.11-0.23 ng/a,
'•t wt





















a) »ot gim
b) lot glT«>










•BIB | GtEtEll IBPOH1TIOB
1
2.7 * or - ».i I >•!«
g/g (mt «t) 1
1.9 * or - 0.98 1 MOB a groap of *1 aatopaias.
g/g (»«t «t) 1 fatmile aatical •laaiutiami, Japan.
I Bfllctf* Baan aga 40«C yir« Ta>alo»
j a«ai age 37.* TT.
t
1 met ZIEBBBTS; inoMiES; JIPIB;
t IHBIIBR: 1BSEBIC; ciouina: coBUt:
| CB1CSIOS; CCJJIS! 1MB- BlgCOET:
^ iBtni; MSKSIBB; IM«HISB;
I lotmm; IITIBOBI: SCIBBIIH:
| EtlEBlV!!; 711aBlQS$ T&BlftlQB; ZIBC;
| CCIB; BBODIBE; UTEt: nDBBTS;
| CltmUS; CtBEBHUBi BUB1: BISCtESi
i fiBcaus: mm: tnies; torn:
1 llt»13: COBtlBlTITB CTllOlTICIS; SEIi
| rCBEISIC BtCICIEE
1
1 0.19 gg/g 1 a) Coatrols
1 0.20 ag/g I b» lerkcr «TS; SBEITEIS: TtlmSIBB
1
1
a) 269.7 ppb 1 a) S« It. n
b} 176.1 ppb | t) 5* TI
Tna% «t | litopci**
t
I Ciaadlaa IrnJlan, oortivaiat Ontario
| fISBBSJ rCOD COVTMIBItlO*!
I 11IHSTH1I JOUnTIOB; WPOUTIOB
I IIMSOSE; BQBU ItBIS; DBBH 1BB1S;
1 IIIZB rotimoB: iticnn: BEICHBT
I CESIBTC coifcorM: snniiHi BUKB;
| BUR; XIDIItS; LIVEB; FL1CITII:
i SHIEE; ctBitt: inopsiEa
BEFEEEBCt

Tnkaia, B.
Sazvki-Iaaaaoto, I.
lauo, I.
Tarai. B.
994
rchiras of
^nixouental Evaltb
35(1):3*-M











ElOB*. D.
loclkerg. G.
(•star. P.O.
19SO
Sclaaec of the Total
EnvicOBaemt 16t13-35'



















Cappoa. C.J.
Salth, J.C.
1981
Joarnal of Inalytical
Toiicology 5:90-98







ittn «*eB)
-------
s«l«nlu«
7782-49-2
Se
l» 79.96,
           BP 170-217 C. BP C«5 C. T*  1  aa  Bg  at  3W C.  10 •• Bg at 4.29 C
                                                                                      (COITII9ID)
TISSB!
4454
lung
4455
4458
Basel*
I exposing som
1



IBltTTICU
H5THOD
n
•i
i
•OHBIl
or cists
•2
a) «
b) 13
0 23
C
4
IUU
0.52-15 ng/g (««t «t|
a) 0.044-0.22 njyj
b) 0.068-1.56 ng/g
e) 0.00 10-0. 301 ng/g
»et »t
0.67-3.3 ng/g (mt vtl
0.57-2.2 »g/g (««t «t|
1MB | SIIIBII. IBrOSBMIOI I tXrCECBCB
1 1
1 _J._._ f
1 1
7.» + or - 10 aa/g | rtaales j Takam. I.
(Mt «) | t sanU-Tanaoto. B.
I Icoa a eroap of C1 aatopales, | leaao, E.
1 forensic aedical elimination*. Japan, i teral, B.
1 Balm. aeai age 40.* rr. resales. I USD
( HI* ag* 37.4 rr. 1 IrchlTM ot
1 I >CYironB«ntal Health
l mcx zvBBZws: IBTOPSISSJ JIPIE; I 35(i):3«-»»
1 iiBBiBis; IISZBIC; CUBIVB; COBU.T: i
I CBIOTIiT*; CCPPZB; 1MB; Bncntr: I
( ItCIOB; BlSHSin: BHUIfSI; 1
l IIUDIBB: aniBOBT; SCMDIDB; i
| JltlBIia; TIUBIW: VIMBIVB; ZIK: I
| eOtDj SBOBTIE; UTEB; KID11TS; I
| C!«lBHJ 55-76 rr, eipoaed to 1 EnTironMot 14:13-35
< aea«T aetala 1-3 decades. Ttae (
j cetMea r«tlr»a«ot aal deatt 0-1.5 yr 1
1 ii groop I aid 2-15 jr, gcoaf II. |
1 controls, ages 43-72 TC, vho Uwd 50 I
j k« froa the factory. Sveaei. 1
1 1
1 iftiEt; cuiims: Kitastss IITEB: i
1 loies: coB»iM?in mintiois: i
| JIBBSIBI»t BISIZBE: niSOSEBIBT I
| I1TB09S; inlBOITi IBS IIIC : CIDBIHB; 1
1 cisiDS: craoBina; COSHT; COFPSC i
| CO ID: HOB; tlBTBUOt; LEIB; (
| tllGlHSS: BSECfflT: BOlTBOtlDB: 1
1 tsospBOKBs: uraiDiUB; scimims i
1 siiiiini; aims; TIB; TDBGSTSS; i
t line: aiaitB Biiugs: IIDOSTBIU i
| IIliTS: SMIIEBS; TJLIDBIDB |
1 1
2.1 * oc - 1.1 fa} Bales I Ynka«a, B.
g/g (««t ot) 1 t) reaales | SnicU-Tanaoto. f.
1.1 * or - 0.76 I I llano, K.
/g (net wt) t Troa a groop of 61 aatopslea. I Terai, a.
| forensic ae4ieal exaaiaatioas, Japan. ( 1»eo
1 Rales, lean age 40.6 rr. fvaeles, 1 Ircbives of
I lean ag* 37.4 rr. | EtTlronaantal Health
1 1 35(1):3«-44
| 151CE nSBIRS; 1QTOPSIK; J»1B; 1
l utBiivB; nsmc: CIOBIOB; COBUT; i
I CtBCBIIl: COPPZE; HOB; HEBCOST; 1
| IBtlTV: B16BESIVB; B1BS1BISI; 1
1 I»*IBIBS: innoir: sciioioi; i
| 3HZBIH1; TI1UIOB; TtBkDIOB; ZIBC: 1
I eciB: B«o«iii: IITH: KIDBEIS; i
I cfimoi: ciaraiiiog; ajisi; RVSCISS; I
l tincssis: spiral: tnvss; tent: I
| BrTILI-. COBPUtTITE CTUOJTIO1S; SSI; |
( fCJIKIC BZBKItE 1
1 1
                                                                                                                                                                                          NJ
                                                                                                                                                                                          vj
-------
Seleala*
7702-W-2
S«
lt» 7B.9S, H 170-217 C,  BP 685 C. TP 1 •• Hg at 354 C. 10 •• Bg at «9 C
IISSBB
**57
nil
MSJ
Pancreas
M59
Tltceat*
»»so
Spinal
cord
POSIWE MOII


Ingest Ion

iuiRicu
mioD

i
..
ac
1
1UBBES
r cisss
»
(1
C
> 3
1
a» 1
b) 3
tUSE
lot gireo
Bot glMn
1 1.1-3.S og/q (mt vtl
1 0.»7-1.6 ag/g (vet «t)
a) 23. 3- SO. 1 ppb
b) 6. 3-16. « ppb
a| lot applicable
b) 53.0-180.2 og/g
RBII i sunn. iBTottiTioi i BBrnncB
1 l
1 1
0. 18 * oc - 0.59 | •} Cosea 1 Kaubrocki. E.I.
ppa | r) Bea | Kanabroeki. J.li
0.58 » or - 0.27 | left thaab I Greco, J.
pa | llso re»iew4; kao» levels of 30 t Kaplaa, E.
FT (t I ctker eleieat* 1 Oestac. I.T.
1 1 Br», s.s.
| Bailtkr 20-6C rr oiaa { Gaatafson, r.S.
I 1 1*1800, D.I.
1 »t TOTS; SEX; mis; sstnij ILDRHOH; i iioare, c.i.
I UTiBowt; tusnic: IUIDH; CIDSKTR; i 1979
I CUCin; Cisni: CBBOnni; COBIVT; 1 Selavee of the Total
I CCPPE8; SIEHUItJB; SC1.0: Itoi; LE>0; I Enironaent 13:131-1*0
| IteiESini; BUSUESC; ICEKCOST; |
I IClTBIini; IICKEL; POTlSSIOa; |
I BOBioinH: siinni; smcoi; sima; i
| SOtlOI; STBOITXai; Til; TIHII08: |
I fii»ivB; UK; IIECOIHIB i
1 1
1 1
1 2.3 » or - 1.0 | «> Bales \ Tnkan, 8.
g/g (vet »t) I t) teaales I Snznki-Tasaaoto, R.
) 0.89 t or - 0.62 | 1 »aaao, K.
9/9 (vet vt) 1 tcoi a gro»p of C1 aitopsies, I lerai, R.
j forensic aedlcal exaataatloas, Japan. I 1980
1 (alee, aean age »0. S jc. feaales, j trckiTes of
1 teaa *ry «t | lentral bora tiasae, avtopsf I 1979
| lo detectable Se la 6 other patients j laaals of Seorologj
I aa4 9 controls | 6(l)t21-2»
1 1
1 1! TI oU an dial of progressive 1
1 avacalar dlctcopkr- "7-67 TI old 1
| centrals, dlcl froa chronic ceual \
1 failaxe, breast careiaoaa. and I
I ceroitaTT artcrr diseases. |
1 1
I 1'TIS; 1DV1TS; iOTOPSISS; |
1 1IOSOHUSCD1H DISEISIS; SPIBM. COST); |
| ElOlCdinilTlOW; ClLCfOIi COPPEB; I
I TBCI; litt: RHGtRZStt HETILS-. 1
I sitirriR: zitc i
i i
(HIT *IBB)
-------
TTM-W-2
3*
at« TS.4C.
              1TO-2IT C. Bf «*5 C. TP 1 •• S? «t 3S« C. 10 M Bg at »29 C
                                                                                     CCOBTtlVtD)
TISSBB
•Ml
SplMB
M«2
Splwa
MS 3
vrica
««<•
Brine
MSS
9rlm«
EivosnE ion

lBf*StlOB
BgeatiOB


IIllRICll
BKBOD
H
ec
us
l«arl«i. 1 T«r»l, S,
1 fOTCBcle »»alcal extilMttoa*, Jap«o. | 1980
I >*!«*, M*n tcj« 40. < tr. F«ul«a. I Jrchliei of
| MM (TC 37.* TT. 1 ZBTlCOBMBttl B«»lth
| I 35(1):3C-M
1 ttice H.BHMIS: AOTOFSIBS: Jirii: i
I unnirav; »»St«IC; C»»HIt)»; COBIXT; I
I cERonma: comi: itoi: IEICVET; i
I JIDIOI: iieKsniB; uientsi; i
1 imlDiuB: utisowT: SCIPDIUB: i
| StlEtXH; TIH HOB; nUBIDB: II»C: |
I SOID: BlOIIlIi 1ITH; KIDIIIS: |
I ctmtvts cEimun; HIM; HBSCISS,- i
| EllCIItS; SPIBII! LVKSi 10IT1: I
| BIT IIS: COSP1BITITB BT*L(TlTIC«Sl SIX: I
| fCRKSTC HIDICin 1
1 1
1 1
•I 2«6.6 ppb | «l S« II. IT | C*ppOB. C.J.
b) 1*2.4 ppb ( t) Si H | Slltk, J.C.
rresh it | I«top«le» I 1»81
1 I Jcara«l of laalytlcal
I ca>i4i*a IndUa, Boithnest Oitatio 1 Toiicology 5:90-98
1 1
| IISBIS; FOOg COIIISIHTIOI; |
I TiDnstaiu pauonoi; MPOIITIOI i
I IlrOSBlB; DIBU 1BMS: ITFBJ1 1BE1S: I
i mis voiinioi; NICVBT: SBBCOBT i
I oi0iiic coifcttiDS; stimat; BB«»; i
I BUM: KIDMTS; 1ITBI; PUCBBT1; I
I SEXin; Ciiiti: imopsiis i
1 1
79.21 + or - «». 12 I §«sld»ots •«!»» «it«r ftoi nils with | talmtlte, J.I.
g/1 I :e-1800 a? S«/l I Kt*4t R.K.
( 1 Hang, P-l)
1 Iliac, TS | Sckloektcc, B.
1 1 "9°
I I1B BEIICO: BLOOB; B1IB; DBIBE; I Journal of loiloolo^f
I 9ET1L3] SH.IITHB: BBUtUG «1TEB; | ana laTlcoaBeatal
| IIZTMS5: POPOHTIO* nPOSDBt | Health 6:731-736
1 1
t 1
2.3 » or - 8.21 ag/1 I I Gaahehaa. 1.
| | CbMboi. P.
j Bataial. BOB-oecipatieaallT «i posed I 1980
I 11-77 yr old*, tjom. Fiuic*. I Clinlcil Chemistry
| I 26 (9>: 1772-127*
1 sztmni: REIIIS; rsucs; ami: i
( BMSntlBfT BET BOSS |
i i
1 1
063 »j/»l 1 Bapid City, SO, Ml«aH«lo«i aim. I Hon. R.
1 nmklr or aorthly saiplUa. *-2« i>k>. I 1«74
i i archives of
I Maltky blood doBOrs of vatloos age*. 1 BaviroiaeBtal H««ltl
t Seitk Dakota, lyoalao, labrarta, and I 3*|«) :**»-»«8
t lotti Dakota. I
1 1
t sniEToi: BiooD; mil: ram: i
I CCH»BaTITE EVlLVktlOBSi SOUS; SOOTH 1
I C1IOTI; 101TB KlIOTl: ffiBBtSIa: I
i iionis i
1 1
                                                                                                                                                                                        00
-------
JSJ-W-2
cz-i«-r2-si
ft 96.15
TISSUE
•MS
Breath

EtPOSintE 8OBTE


1U1TTIC1L
IETBOD
re/us

•men
or c»sis
8

UK!
'
1.2-UO.O ug/lr

mi
28.9 vg/hr
	 	
SIIES1L nmiUVXOI
_
Coapoaii related to noraal
eetabollSB. «o other Oataila glvea
lealthT allltary *a4 ciilliaB
eiploTees. U.S. ilr Force School of
lerospac* l«4icla«, ages 23-*7 jr. 3
IIKSISS: CBtOKIIaTEB BIBIOCUBOBS:
CEIfltIM OtSlKC COIPOMDS;
cnoBoniimsi nvcnn coiponiits;
iBHTi: itcosots: tins: IDOITS
miiEici
C oak la. J.P.
Caap, B.J.
Belck. B.E.
1975
IrcKlves of
iBTiraaaeatal Health
30 (2): 294-295

!2Q-5«-«
C3-l«-?-S
«1 92.20
TISSUE


SKOSOBS BOOT! I
1


1ULRIC1L
IETBOD
ec/is

imisB
07 CaSXS


BaBGB |
1
lot detect «a-5. 2 ag/kr

HEli |
1
0.7 aj/hr

eiHBll UTODUIOl
CaipoBBi froi BikBOBB origin, lo
ether details 
-------
Silicon
7MO-21-3
SI
»tW 28.086, IIP into C, BP 2600 C. TP 1  » H, at 172« C
                                                                                      (COHTIIUED)
TISSUE

• •TO
si ir

















««7l
Rltaer






HT2
linr



EIPOSVSE SODTl




















Injection







n lection




1
1
1
1
I
1
M7J | Injection
l»9 I






AULTTICll
HETBCD



















US







us










us







IUHBEB
OF C1SZS



















1







1










1







JUCI




















lot applicable







at applicable










at applicable







BZH




















120 «g*







5* «g<










*000 «q»







SEISE1L IlfOSBJIIOB

P«lie». :• reprasentatirs
FC«-*nslTSi3 treatients are
tabulated. I be leasibilitr of a
tolistic, na-irasa palter foe hair
analysia is catlinea and snpportea.
BITIH; TB1CI ELMERS: HUB:
mSTBJUl: RIlSVBEgilT SETBODS;
eiTJIS; tSOTlHS; COBP1E1IITI
ITAlOaTIOIS; »1UBI»OI1: 1IIIBOIIT;
1ISEIIC: BtEIDA; BBOIIIE; ClDHinS:
ciicwfi: ceicBiRE; cmtoanju: COEIIT;
CCPPBl; 5HIIUH; CTSBIHOB: GOtD;
icoiiE: iBoi: Linauvts lEic;
HSIESI7I; auetnsE: OJRCIIBI;
eCITBDElUB; IICKHI.; PaOSPHOEOS:
ECIISSTOS: BBBItltll; SILEIIVi:
Silicon; SIITEE; SotUBS; SIBOHTItTB;
SD1FDE; III; TIUKDH; THIGSTEt;
Hie; zucoiitm


Caucasian, a«< »0 yr.

Cifeoli it lanqs
ivies; Bain: HOOTS: LIVES; BLOOO
SIBII; siticci; CISI aisrosirs;
IOTOPSIES


Caucasian, 890 40 re*

Iitali in Hag*

laiGS; BBIII; KIDRTS; 11 YES: BtOOO
siBOB: sincoi: cisi BISTOBIES;
laiopsits




Clicuini, >9« *0 re.

liboli ic lanji
iqiGS; BBIII; KIIIETS; LITIB; B10OD
SZEIII: siiicci: cisx BISTOEIES;
leiopsrts
BEfSBESCS

CbUtleborongh, G.
1»SO
Science of the Total
Emironient 11:53-75















Solow>na« E.T.
Jones, O.K.
1»7S
Journal of Forensic
Sciences 20(1): HI- 199



SOlOKIK, E.T.
Jones, J. It.
UTS
Journal of Forensic
Scie«cet 20(11:191-199






Soloions, I.T.
Jonea, J. K.
1975
Joucaal of Forensic
ciences 20(11:191-199



                                                                                                                                                                                          NJ
                                                                                                                                                                                          00
                                                                                                                                                                                          o
-------
7MO-22-*
at! 107.86S, IP 9M.5 C,  BP 2000 C. TP I n Bg at 1310 C,  10  •• 19 at 15*0 C
TlSSIt
«*T*
Mir
»»75
Kiaaer
•*7«
Lint
MSVIS IOBIB



iMimcii
BETBOO

I
»
*OBBH
r cuts

> 8
1 21
•) «
« w
IIISE

J < 0. 005-0. 0»S a«/g
I < 0.005-0.18 ag/g
et «t
a) < 0.005-0.032 »4/«
b) < 0.005-0.33 oj/-j
••t rt
iul i CEIHII iiroiamoi i BBFEBBBCE
\ '
| levie*. 2* r«preMBt«ti»e 1 Caittlebocoagfc, 6.
| pre-aaaly>i* treataeata are 1 1980
| tabalated. the feasibility of » t Science of the Total
1 Bcltetlc, no-task policy for hair t Enilronaeat 1»:S3-7S
I aaalysia la eatliaed aad supported. I
I (met; mci ncnrts; Bin; i
I lISTItlll; niSIUIEd BETBOBS: I
I EttaLS; ttotmsi coariiiTin I
I Mimitiois-. limnm; H1IBOVI; 1
I nsnic; Binoa; Btomi; CIDHTUE: i
t ciicrjs; cnains cnciioi: conn: t
I ccrrn; siLtnrn; SEsaiiroe; SOIB: i
I icons; laof: UITKHDB: LUC: I
I a»oi*sio»: uiemsi; SBBCOSI: *
| ICITBDnOBi BICKBLi taOSPBOlOS; 1
| CCtlSSntl; BTOtOIUS: SELIItlH: t
I siircoi; sit TIB; SODIOB; stiomoi: i
I sum: m; winna; monti; i
1 UK; nicciiot I
i "
1 1
) lot give* 1 a) Controls 1 Brane, D.
1 lot giTeo I t) Workers, qroipa I *a4 II 1 lordberq. G.
| I tetter, t.O.
I taoeasei tefineir u< aeeltai 1 1980
( wckec*, aqea 55-76 rr. expoael to 1 Science of tie Total
1 l«»Tf aetal* 1-1 tecalea. tin t Inilroieent 16:13-35
1 t*t«eea retinaeat and death 0-1.S JT |
I ia oroap I ««fl 2-19 Tt, qroap II. I
I Ccatrota. aq«* «3-72 rr. «ao litei SO 1
1 ka free the factory. Svedea. I
| SIMM: CIDIKBS; IIDBCTS; LITJ8; |
1 totss-. coitiuTiTi mniTioss; i
I IIDJSTBIlt 1T6IEII; B!»SOBlBtHT 1
| ttTBODS; HTlSOIt: «BSB«IC: CIDHUJB: |
I.CISIOB: CBEOBIOB: coBiLT: coppu: I
1 coin: iici; unsiiOB: L»O: i
1 iHSaKSt: incnn: SOITBDIIOB; t
| EtOsrHOIOS; NBIDIOI: SCHDIOB; |
| StlEflVl; S11T?R; TI«; TOUGSTM: I
| tllC: BBalTI SillBDS; IIDgSTlIll 1
t mvts; s>itnns; niLotitii i
1 ..._!.__
1 1
a) tot gi»ea | a> coatrol* 1 Brae. D.
b) lot giTea I t] lorkera, gcovps I and XI 1 tordberg. G.
| I (ester, ?.Q.
I te
-------
   Itt 107.SSB. n* f*0.5 C. B* 2000 C, TO  1 » Bg at 1310 C.  10 •• Bg at  1S<0 C
                                                                                        (cormtiD)
IISSVB

J.S




















MTt
•nil
















ixrosvBB BOUT








































ilainxcil
BETBOD
n




















11

















BDBE-SS
or cisss
at 8
b) 20




















•1 9
b) 11
















ur«i

a) < O.OOS-O.OCO ng/4
b) < 0.005-0.02* ig/g
net «t



















a| lot given
b) lot given
















BUB 1 eillBaL ItFOtmiOB
J
a) lot given I «) Controls
b) lot given I r) farters, eroepn I and II
1
I Deceased refleerr and snelter
j sorters, ages 55-7« rr, exposed to
I k«a»T netals 1-3 decades, tine
1 tatveen retlrenest and death 0—1.5 rr
1 li goarp I aid 2-19 vr. groip II.
I Centrals, iges *3-72 it, >no lived 50
| ki fcoi the factory. Sreden.
1
| SlIDEI; CIBtTBtS; KIDIBTSl IITBI:
I uies; coapuifin mtnnais:
I IIEDSTIIU BT.8XSII: BBISmBttn
I BITBOCSi aRIBOII; IBSSRCJ C1MIU8;
1 cismis CBBOBing; COBIIT; COIPEB:
I COID; HOI: I1BTBUOB: 1I1B:
I IlietlCSl; BItCOBT; WIT8DIITO:
I iBospBoins; iBBiDioB: sciinimi:
| SmirtH; SIITBI; TIB; TOISSTBI:
I IltCi BU1TB BlZalDS; IIDOSTIIU
| PI11TS; SBBMEBSt tEIlOIIOB
1
1} 0.7* « at - 0.7* | •) lonei
pps f t| Ben
b) 0.3* 4 or - 0.20 I left thnnb
ppn I ll*o revleved: knosn level* of 30
Dry «t | ether ilenent*
1
1 Beilthf 20-60 yr olds
1
I irtjiTS; sn; mis; ESTIEI; itOHiinB!
1 iniaowT: iisEtic; BititrB; ciBsiH:
| CllCItU; CISTO8; CBBOBZOB. COEllT;
| CQPVBS; 6ESB1H1IB: GOtD: IBOI; IEAI>{
| BISIISPJB- BIBMBESB; SEBCOBT;
1 catiBDitVBi ncKiL; ponssiaa:
| IBBIDlaB: SEIBBItB; SItlCOIJ SItTES;
| SCCIOB: STBOITIIIBi Til; TIT1II09;
| TIIIOHJB: UK: ZIICOIIDB
« 1
EEFBIEICE

Brane, B.
lordberg. 6.
(ester, t.O.
1980
Selene* of the Total
Envlronnent 16*13—35
















Ranibroctl, E.I.
Kanabroeki, J.I.
Greco, J.
Kaplan, E.
Oeater. T.T.
Brae, S.S.
Gestafson. P.S.
VelsOBy 9.8.
Hoore, C.E.
1971
Science of the total
Bnrlronaent 13:131-1*0






                                                                                                                                                                                           NJ
                                                                                                                                                                                           oo
7««0-23-S
la
Itt 22.»am. tt 97.K C, BF 881.4 C, TP 1 •• B« at MO C, 10 •• Ig at S«< C
TISSBJ
««7*
Slool,
serei













t
1
t
»
BIPOSBK MBIE
















1
\
\
1
iiunicu
rnnm
us















\
\
\
t
ItlMXt
OF CASBS
» 260
b) 260














1

1
»-
MBSB
a) lot gitrei
b) lot girea















1
t
i
Bill
1*0.60 « or - 1.W
•eq/l
b) 13B.5S » or - 0.77
•eo/1












1
1
t
«
eBIIML IlrOBMTIOl
•) laisas cltj, ts, Uri-iiter mi
b) taasas Cltr. BO, so(t-«at«r area

IS and BO resident! eatehed for age
(•em aq« 37 and 37.7 T?| , >ez.
liigtn of residence, iiritil and
•conaile states, occupation, inber
cf ehtlim, stoking habits, ht, ¥t.
In hard-water area, slenif Icaat
liczease In hypertension, BCG
•bnocnalltles, ind irperarlceiia.
(lists; H1SSC0H: itottss
C»CIOT1SC«1*I OI3B1S1S:
mirriisiai: noon ssjnn:
ccBfiiaTlTi CTH.OITIOIS: CIMIOS:
cncii«s cBiciitiB: inBiaB:
ii«»sm: IMSPBOIOOS: TOUSSIW:
I sotimj me; sioiccn-nrntioi;
t ntncna »M«
\
nrEBicB
Blerabm, H.L.
nelaehsan. 1. 1
Dunn, J.
•mold, J.
1975
Lancet
1(191«):1008-1016











1
1
-------
So41»
7MO-23-S
la
lt» 22.1*977, n 97.82 C, BP 881.4 C, TP  1 mm gg at MO C. 10 » Sq «t  5M C
                                                                                      (COsTIIVSO)
trssnB


•MO
Balr










_i_
air



















M«2
Balr












irosots tout B

















































iBiinicit
RSTBOD

US
































•1













BDBBBB
OP casts

31
22































a) 23
b) 14
0 »2
4) 1*
•) 26
O »0









B1BSB


Bot gi»«n
lot given































a) 3-19* aq/q
b) <7-»0 noyo;
c) <7-1»9 aq/q
d) 12-196 ««•/«
•t <7-9» aq/q
I) <7-«96 «g/«









B«B | GBIIfU IBPOtBlTICB

1
1
1(37 pps | a) leaning disabled
919 ppa | t) Controls
1
1 learning disabled and soraal 3rd aad
1 «tk grade stndemts 1m Canada.
1
1 ciicna; siGissxm; POTISSIOB;
1 SCDIOS; CUB MB; COB11T; COPPIB;
1 IFCI: LBID: UB«iiBSB; IIBC:
1 cnoBtna: itiBiBB; Bttcmt; anus;
1 BUI: caxiom: ciiim
1
1
1 Beyie«. 2* representati**
1 yea— analysis trttatnvnts ara
1 tatnlated. TV* feasibility of a
1 nelistle. no-*ask policy tot halt
1 analysis is outlined and supported.
1
1 iivin; TBici stiazns: am;
l issniLii: BUSDIBBBIT BBTBOES;
I mils: Ptornis; cowitiTin
I IlltOltlOBS: 11DBIIUB; iniBOIT;
1 nsnic; siHoa: BIOIIR; CUBIOR;
I CIICIDB; cairaiK; CBBOSIOB; COIUT;
I coppts: oiniuB: eEMinva; GOLD;
| ICBIll; IBOI; tlBTBlBVI: 1»I;
1 tisBssraa; BiaeiBssi: RSICIBT:
1 iciTBDBna: UCIIL; PSOSPHOSBS;
I IOTIS3I1S; BBBIBIBB: SJLIIKJS;
| SILICOI; SI1TBI; SOOIHI; SIBOBTCTa;
1 SHLP01; TIB; TITlHtlB; TOBG3TIB;
1 IIBC; flBCOBIOB
1
a) 3* «g/q I a) Bale costcols
b» 3 aq/q | k) Fenale controls
e) 1« »q/q | c) 111 centtols
d) W aq/g | dt Rale aaltiple sclerosis patients
e) 9 aq/g | «) Peaale saltiple sclerosis patients
f) 1* «q/q | f) 111 aaltlrle sclerosis patients
aedians \ Staple* fros 7 scalp sites in eack
t sablect.
I CIB1V1: ICtlllS: CBRSll niTCOS
1 StSTIH VISH3E5: BUS; llOBIBOa;
1 ciORiis: cucnR; CHIOBTH; COPPEB;
I SOU; IODIII; aiasiBBSB; aiTUS;
1 3tl!lT01; SItrEB; SOBIOB; S01POB;
I viiion*: UK
	 1
BBPE1EBCE


Fibl. B.C.
Carkes, B.
977
Science
198{*313):20*-206







chltUcboronqh, G.
1980
Science of the Total
Enrlronaant 1«:53-75

















Hyan, D.I.
lolxbeener. 1.
Sturt, D.C.
197«
Clinical Ckenlstry
2«(1t):1«9«-2000









                                                                                                                                                                                            NJ
                                                                                                                                                                                            00
-------
Strontium
7««0-2»-6
Sr
it! 87.62. at 357 C.  tt 1366 C.  TP ID « Bg at (48 C,  1 u Bg at T«0
TISSUE
««*3
Kir

















EIPOSORE BOOTS



















1I1LTTICU
ffiTHOD



















iron BIB
or CISES



















MISS



















Bill



















GKHBal IIFOSHHIOI
B«Tle». 24 repreaeatatiTe
Fr«-»B«lTSi« treataents are
tabalated. Tee feasibility of a
holistic, »-»ih policy for hair
aaalrsls is oat lined aad sapportea.
mm; TSICI ELIBIITS; HUB:
lOSTBUIl; IBlSOBIinT BKTBODS;
BITU.S; PBOTU1S-. COBtaUTITl
iTiinfiovs; itninnH: jmHoir;
usjrrc: BJBIOI; BBOHIMS; c»xira:
ciicni: cetcsiiB: craonoi; COBU.T:
CCPPBE; StlLIUB; GEESillOB; GOLD;
ICDUE; IBC1; IIRBHVI; IEIE;
BieiESIDI; MVGinSI: IBECIBIt
fciiBBHOB: HCEH: PHOSPHOBUS:
PCIISSIUS; ETOIOIDB; SEIBIIUB:
SIIICOIj SI1TEBJ SODIOB; SIBCrilBH;
SClf OR; III; TXTMim; TOUJSTEK;
fHC; ZIBCailSJB
SEFEBERCE
Chittleboioagh, «.
1930
Science of the Total
EnlcoDient 14:53-75















       re en
       «tbearl-
  101.1*, HP -3t C. »P M5-1M C, n 3».« ati tt 37«.« C
tissvi

«»a»
BIooJ,
•hole










MBS
Rrlie









EIJOSOBE BOUTI

Inhalation












Inhalation










IHITTICH
HETBOD
sc/ns












«c/«s










MOB BUI
OF CiSES
«

I










*










UltiS

a) lot giT«n
b) lot 9 Iran
c) Rot given










Vot gir«n










IEJLI

a) 0.« ng/ml
b) 0.92 » or - 0.26
ng/«l
c| 0.01 09/1!








-
2.12 * or - O.BO
•illiioles









etllUI UF09B1TI01

••) Initial lalae
t) peat, at 6 hr
e) Final valie, at »7 »r
Dcs« «as 90 pp«
a> anS a} estlnatel froa gcaph

Healthy Caucasian 2«-«« yr olds.
72.«-*0.7 kg.

•Off* odor, ilia eye Irritation, van
eeawtlon is face.
STTtmS; SICOO; tllUattOI: lOOLIS;
CITIf; HtTlBCirTES
»S hr lean eicretions o* aetabolites.
ian4ellc acid and phenTlglTOiilic
•eld. Dose «as to ppa.

Icaltay Caaeastaa 2***< rr olfla.
72. 6-90. T ka.

•Cff" odor, aild ojf Irritaltoo, wars
sensattoa in face.
StTtNES; BLOOD; TIH1HTIOI; IDVLTS;
UBIIE; HETIBCLTTES
BEJE5EHCE

B»a«r, J.c.
Icing, J.D.
Karbovskl, B.J.
Chenoveth, B. B.
HcCartj, t.P.
Brian, i.e.
1980
Tozicology and Applied
tharaacologr 53:5a-6J




Baaaer, J.c.
Tonag, J.D.
Rarbovskl, E.J.
Cnenoveth, B.B.
BcCartT, l.P.
Braan, I.B.
1980
Toilcology and Jppliei
Phuraacologr 53:S«-63


                                                                                                                                                                                      to
                                                                                                                                                                                      00
                                                                                                                                                                                      .p-
-------
 Siltli*,  ntlrt propTl <• Cl)
 Prof tarn,  1- fMthftklo)- f» CD
 3!77-f5-»
et-Bio-s
01 90.1*.  IF -113  C.  B» 95.5» C
TISSttE
•age
Breath


EXPOStTBB MOTE



tniTTIClL
SEtBBO
8C-SS


or CUBS
"
S« (387
naplas)


BMSS
lot giv«a


sui
SaoMtric


G1IERH ZVT0194TIDV
B«aanr*l at 25 C a*4 7«0 aa •«
11. 5t oecmtme*
IOMC afl appn oa*-Slgaa Halts 0.39
*«4 5.1 mayl
ecaltkTi. 1B-3S TC old. nonaMlting,
CHcacjo, II. iiqidly controlled
tipatlacntal caaUtiou.
mug; 11COHLS; IlLItOIS; 1DUUS;
ceitnrnun BrosocfiBOis; TOIITILS
CESIE1C COEICHBOS: BHI.TH aiZlBCS;
IimntlO": aiTlEOllSa; antBOLRES;
IOPBI1TTOI TIPOSOM: DEBIE *BB*S
taaeK*
BEHBMH, 6.B.
O'Vaill, B.j.
W7S
Joamal of laalTtleal
Toiicologj 3:225-23*


 si lew
 n
 s
     32.06«,
                      C, fit abort *»».& C
1ISSVX

M87
BrtMlli








*.*B8
Uttlr
















»••»
Balr









:IPOSOB1 BOVTE

Inhulitlon






































aiunmt
HETBOB
PIXE



























n










BOBSIE
or CUES
1



























a] *2
b) 10









jHGt ~~

lot ql¥«B



























a) 2.T7-3.99*
b> 2.46-3.73T









am |
1
S.9 n«



























a) 3,'sr
b) 3.23'
BleUaas








GEIH1I IIFOiaiTIOI

« 1 saaplaS it rat* of 1 I/ail. 2-10
•In aftac baralaq * arc ««Hin E*pr*««BtatiT«
(iv^aBaLTftlc traatBVBtc act
tatvlataa. Th* f«»«lblllti of a
leliatlc, no-*»»k pollei fax hair
aaalTaia 1* cmtlln«4 aad supported.
tlTICT: TB1C! tiimwts; Bin;
ICSTBtHl; BIASQBVBBVT RRBQOS;
irtiis; fBornis: COBPUITITI
fiiimiOES; itvalKiB: IRIBOIT:
1SSCTIC; BUIUB; BIOBIIIj CUMOT;
ciicnrB; CBicsiii: ctmoaius: COBUT:
copvn: smma: OEintnvB: COLD;
»6B«sioi: aiasujss: BEBCOII:
BOtlBDIIHH; 1ICKS11 nOSPEOlOS;
CCTIS3IVBS VBB1BIV9I; SBLEVI1TB;
S1IICOB; SXLTEI; SODIDB; SIBOITHTJ:
SVlfm? Til; CTY1VXDB; TVBGSlEt;
1IBC; IltCOlIOa
a) Coitroll
tl 8alti.fl* iclccoalc patlcata
Saapl** fxoa 7 scalp aitaa la each
jvb 3*et

CIII01; IDOITS; CEITU1 IE B TODS
£T3«B DISUSES; "Att; 1LOBIIQB;
BIDB»E; cucinn; CRIOBIBE; COFFEE;
ccto: I09IBE: BHCUESI; EETILS:
imiins; sitTini sooioii; snrm:
tiiioivs: ziBC
EEPE1EBCB

Unlsaon, t.B.
Dasaaa«l*er. G.6.
Joktuaoa, T.B.
Uncb«ater. J.t.
W7*
lanala of Occapatioaal
BT9l«B« 19:225-23*



ChitU«bozo«gh. 6.
1980
Scl»nc« of th* Total
EnTitOBMut 1«:5J-75














Byu. D.E.
Eolxbeckcr, 3.
Stuart, D.c.
1971
Clinical chnlatCT
21(11| :199S-2000





                                                                                                                                                                                         to
                                                                                                                                                                                         03
                                                                                                                                                                                         Ul
-------
Tellarlaa
13494-sa-*
I«
Bt 127.6. IP 449.5 C. ft 989.8 C, »P 1 ma B» at 520 C
«ss«
4490
xidaey
»wi
Liver
4(92
Laag
nfosm BOOT



kuimcu
Banco
n
u

BBBBEB
OF C1SSS
•1 «
M 19
a) 8
b) 19
8
19
IMG*
a) < 0.005-0.33 ag/g
b) < 0.005-0.2* ttg/g
let *t
a) < 0.095-0.12 ag/g
b) < 0. 005-0. 12 «g/g
Vat «t
< 0.005-0.025 «»/g
< 0.005-1.06 qg/g
at vt
Bsii i CBIBIU. IBPOMMIOB i nramicx
i i
1 !
a) Rot givea I a) Coatrala 1 Brate, D.
b) lot givea | I) Workers, groaps I aad II I Borabarg. 6.
1 | lastor. ?.0.
I laceased reflaery aad laaltai I 1900
j ccrkara, *ge* 55- TC ft, expoaed to 1 Scleace of the Total
I taavy aetala 1-3 decades. Claa 1 Eoiironxint It: 13-35
I tatnaaa ratltaaaat mtt daatl 0-1.5 rr 1
I ii qroap I ul 2-19 TC, gceip II. 1
| Coatroll, aqta 43-72 yr, *to lital 50 (
| ka froi tka factory. Svadaa. 1
1 1
i sitwi: eatiTBSi KiDasrs; iirsi; t
I uiss; comiinn immiois: i
I iiDBSTiiii noiEHi actsomni i
t BIT BOBS j innoit; usnic; i
1 inimna: ciDfliiB: cssim; CBBOBIDB; i
| CCBalT; COfPIl; COLD; IMI; I
1 iiRBitui: LIU; uieiRSB: nictuT: i
I lomotnB: laospsoiiis: BDBIDIOH: i
| SC1IDIDR; SBUIIOf; SIITEI; TIB; I
I TVKSTK: ZIIC; BJ1ITB HEUSDS; 1
| mOSnXal PllITS; SIU1TEBS |
1 1
1 1
a) fat giva* | a> Coatrola | B£vna« D.
b) Bat gim I t| v«rkats, groups I aaft II ! lordbvrg, S.
I 1 Waster, P«O.
1 laeaasai raf laarj aad aaeltar 1 1980
] icckars, a; BIIGIIBSB; BEBCTSI; i
I BCIIBIIBO'l: fflOSPBOIBS: BtTBIBIBi: I
1 scMDins: snttiDB: snrzB; TIB; i
| IHBC5T»: IIBCj BBU.TB MZUtS; 1
| IBOISTIIll ?11»TS: SIBITBBS I
1 1
1 J
Bot given 1 a) Coatrols | Broae, 0.
lot girea 1 r) lortecs, gioaps I ud II 1 Bordbacg, G.
1 | Waater, P.O.
t taoaasad ref laary aad aaaltaz 1 1980
I tcikers. aacs 55-76 yr, axpaaad to t Selaaee of the Total
I Iraarr aatals 1-3 Oacadas. liaa 1 Hnricoaaeit 16:13-35
| tataaea iatlraa*»t «»4 death 0-1.5 yr 1
1 la group I aad 2-19 yr, groar II. 1
I Coatrols, ages (3-72 yr. aho lltai SO 1
j ka Croa the factory. Svedaa. 1
| SMOtB; CICaTXRSS EI9BRS; llTBi; I
| IOBSS; COIPIHTITB ETltHtTIOBS; I
I IBEDSnilt BieiEBS; BKtSBBEIEBT I
| BITBODS: aBTItOBT: »S*IICJ 1
I iiitraivB: ciD«m; CSSTOB; CHBOHIBB; i
I CCIILT: cotrn: coin: isoi: i
| tlKHJUnS; HIS; BaBCllBSI: BJSOJST; 1
I tOlTBOEBtm: tBOSPUOlOT; BDIIDITia: 1
t 3CMOID3: SCItBIOB; SItt'B-. til; t
I 1B1GSHB: tine: Hnm BIHSIS-. \
\ IIDITSTII.I HUTS; SBSLTIIS 1
1 1
                                                                                                                                                                                       to
                                                                                                                                                                                       00
-------
t«rt-Mtrl iinlflt* (8 ci|
nl*«lfld«, fci*f1.*-dlMtkrtet»rl|  C»
CI-8U-S2
II 178.3*
tissn

«W3
Brcatk











sifosvn Mm













lutmcu
BITBOD
OC-BS











fJBBEF
or cisss
5% PB7
sa*pla*l











tues

lot glm











n>i
-
0.509 »g/l
0*oa*tllC











eiBtBu, inoBBMi«B

Rcaiond at 25 C aad 7 SO •• Bg
21. M occurroc*
le««t »»1 ivpar o*«-Sl.
Cticaqo. 11. sijiSlr contzoUcl
•tpnlmtil condltlots.
flllTB; I1CCIO1S; I11IIOIS: 1D01TS;
CE10IIIITID miOCllMfS; WllTILE
ciGuic concnos: RIIITB IIZUBS:
niitKTci; imtoiissj imiEounss
ICmiTtOI IIPOSISB; D8B1I UMS
isnsnirci

KtataniDiki. B.K.
BCUCN, 6.1.
0*1*111, S.3.
1»7»
Joarul of taalTtical
Tnicologj 3:225-2M







 11
     10*. 37,  B>  303.5 C. B> l»57 C. T? 1 M Bq at «25 C. 10 •• Bg at  1000 C
1 tissut 	

MM
cerebrosp
Ival
flald









Saliva













nnsm tens

l»«*«Uo.











-














1BU.KXCU 	
IBWOS
las












US













IDBBM
Of C1SM
1












1













MB6B

lot givex












a) «-0. 2 ag/al
b) 10. 15-9. IB ag/Aar













	 isii 	

0.2 ag/1












.. - ,
a) lot glna
b) Bot glr«i













GCIlnl IITOISITIOI |

! dari after 1 a.

28 jt old, koapitallnd * dajs aft«c
lagwtlag tkalliaa Mltato.

lover abdoalaal pai»v aavcaa.
>TC«r*sthaala of lliba, roalting.
l«tbam, dte«*lMS*, dacraa««d blood
Tt»a«r«. len of scalp aad tody
kalr.
mttios; iiiiL Foiscwiis: CASE
11S1O1IBS: 01I«1; SttlTl; IT1LI:
ftCtS; SOICICt; CEtBBROSVIIU TiaiO
a) 7 aad 23 S«T» a(t«c t g
b) DCT< 7-» aid 23-2« attar 1 9
San valaes aatiaatad froa gzapb

26 JT 014, koapl tallied « day* after
iaq««tl*g tkalliaa calfate.

locer akdoiiial p«ia, aaiee*.
hi^ecaatlieaia of llab*. voiltlag.
letkargr, drevaiaaaa, dacreaaed blood
|t«*nre, Icia of acalp aad bodf
bair.
ICUUHB; Btlll fOISOIIIS: CUt
iisiotizs; nintj sutft: ITUT;
nets; smciiz; cnsBiosmu. naio
XERBHCB 1
1
(ickelal. r.
fioao, T.
iSaardla, I.
retrial, B.
Banto, 1.
1980
icealm at Tozleologr
(3:321-325





Blchelai, t.
Bono, r.
«aardla, I.
recrixl, B.
lano, 1.
1980
trcKlTes of Toxicologi
43:321-325







                                                                                                                                                                                        t-J
                                                                                                                                                                                        09
-------
  Italltae
  Itl 2»>.3T. II 301. S C. B?  1*57 C.  TP 1 »a So at 825 C. 10 aa Bo: .t  1000 C
XXSSVI
419ft
Vrla«












imsns torn
I»«**tlOa













immcn.
•rraoo
us













nun
or ctse
,













itiei
5.6S-0.2? »9^«y













mi
(at * | | i) tot giT«B
1
1
1
1
1
1
1
1
1


t
1
1
— — — . 	 *
1
t












uti i 6! ni»t uroiunai
1
•
a) S.3 Dj/al | a) I?0 aa/8 ir ta «t«dr »t«t»
bl «. 9 m/il I t) 350 •«/« kr plu 100 aq
1 aHopariB«/8 kr to steady atat*.
1
1 t«a-*aok«ri, aa«* 29-35 yr, on
1 iaatklM-fr<« dl*t »8 kr.
1
I I9SI11I.I1; ItalTS: BLOOD PllSfll;
1 otiitt oivs iirsticfio*: noes:
1 CCHMRITITt ITII01TIOIS:
I TBiopmiiits; tmnsi BRIBOIISI;
I imtotrres
i
1
a| 104.9 tor- *.$i! of | a) 250 aa/l kt
dos* | t) JSO ag/* fcr plu 100 ag
t) »*.B »or- 4.5* of I allopariaol/t kr
do** 1 TiMpkrUla* pl«a a«t*boltt«, ataadr
1 (tat*, ta 8-hr arlm. > SOU aa
1 1,3-dlMthylnrtc aeU. Data
1 anllabl« fct IT doa«.
t
1 lea-Mokara. aq« 29-35 ft, on
1 xaatkliw-fr*« aiat M kr.
1
1 itsniui; leniTs: HOOD PUSBI;
t OlttZ; 9(03 mitlCTIOI; DBOSS:
1 CCBtHlTlrr (TlLOIIimS;
I ittotmiinsi snins: imeociSRi
1 KiMotms
1 1
i nnmcx

i
t
1 STTfUl, J.J.
t 'la?. I.H.B.
1 Farka*. J.
1 Birtatl, D.J.
1 197*
1 clinical nacaicolojr
1 anJ Tkarapaatica
1 2«(5):««0-««7
1
1
1
1
1
I
1 CrrgUl, J.J.
t (lav. !.»-».
1 Fatkas, J.
1 Blrtatt, B.J.
1 197»
) clinical Fbamacolo^y
1 M« Tk*np«atics
1 2« (SJ : ««0-«<7
1
t
1
1
1
1
1
1
1
                                                                                                                                                                                            NJ
                                                                                                                                                                                            00
                                                                                                                                                                                            00
-------
            melt, ioi«aioaiir?ie*l oatlmts

ItULTS; BBM1 DISSISB; BtTOmSIOB;
noon-, aniBTntntsiTB IBIITS; noe
TKIUTt COBIUHITB ITfllOmOO:
smsran curai; TKOCIMITBS
a) SaokvrSr attar 0.032 if/kg fa
•actaria, IB iasa, 2 >k
t\ Sab*tact9 a>4 dosa aa ia a) v attar
1 ao abatcatiom froi sacking
Staa$T stata 1»»»1. »•«>«
• l^itifieaatl) AlCfaraat.

(aaltfeT 19-(0 ?r olfta, saoiei at
l«»«t t jack of elaanttai/oaT.
tlUSS; 3BOII16; TOB1CCOS; IICOD
tusus coBtumn wuonioss;
IVTlCQUllaVISs BWIB01I3B; TI1IBSS:
TBIOCtlBtllS
xsrtiact

Bognn, B.
ttOXOtf J.
Xarcki, J.
Giert, 3.
lagltli. t.
Bitkov8ka« B.
Colabak, I.
1979
Clinical Chaaistrr
25111:60-63
-- _
SaAaaBB, K.
Shapiro, S.
Taltoa, B.
Carroll, r.t.
SalliTan, T.J.
1979
Clinical Vaariacologr
aa4 TharaDaoticA
25 |3) S 309-31*




          p«BtaB* (lo
nssn i
•Ml
Breath












IttOSTOt BOOTI














1»IITTJCIL 1
vmvob
OC-HS













BQRBiS
or cisis
SO (3*7
naplu)












BUGS
Hot «lT«a













Ola I
0.421 og/1
OaT< 18-35 rr 014, nomaoklwi.
vctaa blacki aa< Caucasian.
Ctlcaqo, It. liqlill eoatcoll*!
«iB«ri«*atal condition*.
tBUTB; UCOtOLS: IUI10IS1 UttllS;
CHOBTI1TED BTDBOOIBOIS; 1OHTILI
cteuic coBtcoios: BBUTB BIUBCS:
iiauaTiOB; «rriBoiisa; BRIBOI.TTES:
fCPBtlTlOX lirOSOE!; OBB1B IEJIS
Bxnmcz
Etoto«T»»ii. B*K.
Bctncao. G.I.
O'Mlll. B.I.
1979
JOUMl 01 U»lTti=«l
TmicoloaT 3:225-234








K)
00
\O
           *,  1- (8 CI)
                                                             CI)
   91 776. 13, Vt 235-236 C (4«eo*p)
IISS11
• 502
eiooi.
tervat



ixrosnii BOOT!






inLnicu
IIITIOD






BtlBBIE
OF CISS5
2*3





BUGI
». 5-11.5 ag/100 al





BE1B
7.7 DJ/100 «1





GEiiiii iwrosainos


HCfPIOI'S: BIJSOBI1MT HETBOCS; BLOOD
smn*: Tttis

-
KIEtESC!
Broun, S.I.
•vtbeav^t J.
197*
Joortil of
Pharaacvatleal Sciaaces
«(B):11W-1217
-------
tig
7M9-J1-5


Itf m.C*. V 131.5 C, BP 2507 c. fP 1 •• Bg at 1C10 C. 10 u Bg ft M»0 C
I tissn i ixtosiu totn
i i
• i

































t 1
(503 I
lair


















a50l
Vale
1































lUtRICU
HCTBOO

































.
1

•ram
or CISBS

































MICE
















nil i esBEiu Mfoiawioi
I
i
i
1 tarln. M rapnsntatira
1 fre-aaalrsf a tr«ta«t« an
1 tabtUtvt. Ths fusibility of a
1 aelistie, ao-msl roller for hair
1 laalysi* la cotliaa* «n<5 «ipport«a.
1 tmn; met HUHTS; nil:
I lesnuti: mmmn serwesj
I (nits; itemise cotPiMTin
1 iTimnoiS: imiliW: iniwntTi
j nsnicj Bum; uonis; caraxm:
1 cucxoi: CBtaiiBt cRonoi: coeitr:
j ccffit: giuim: CTMHIBB: COLD:
1 icoiii: I»os; iiRiiini: l<»:
1 neiMUi: iiiGiissi: sncsin
1 loiTioEioB; nc«ni Mospnows;
I IOT13SHB; IHKlalVB: Sill HOB;
j I JI1TCOI; SIITBB: SOOIIBJ SIICIH0II

















1

i
• 1
I
\

1
•ws n


















































































a) 8 1 a) < 0.3-6. 87 s«/g
b) 14 1 b) < 0.3-S..W ««/»
| Bat «t








































1 3n tat; tit-, nruiii; TnEstn;
i me; nicoiing
i 	
1
| 1 ta>*i«v of >ocl4 lltaratar* OB taa>
1 a«c«atlatioa «»* blacoacuttatlon of
1 nlactsl toxic trac» aattli la amua
I kale aa4 aalls and otkcr aaaaaliaa
1 aair. far. atils, elans ail hoofs.
I Ktalatad bf geographic ana.
( *it5«eta-, ttt, a««, cxposara
1 gtiaivct, a»lrsas la pp*. aafl
1 ictaarltr fr«a or»r *00 za>far*Bo*>.
1
t irtrci; iDstiuii: CHIBJI! czniii
I iinici: mtctti iTDOtt list; in
t if HMD; SOUTH mild; somraasr
I mi t oviTte KiiGBoa; ontti stuts:
I fin; laits: imnt 4irin>ii:
1 »s»xc: BOBOI: ciBini: cnoiioi:
1 CCSU.T: ceatts tu*t racoti:
4 iicnt; snmvv: r»: u»oni; in
f (OtlOTIOl; IITUI *OPOHTIOIS:
| tTOICCOBOLKlOls BIOIBDICIIOIS! LtIO
I EOimioB: ropOLiTioi szposiru: run
I poitinios; TIICB Hire rrs: amis
1 lot gl**a 1 a) Covtrols
» fat eima 1 t> lockaca. grovpa Z tad II
1
1 r*c«ui4 rcflMty aad aaolter
1 •oikaca. agaa 55-Tf it, •xpoacS to
I l«»rf aet*l> 1-3 ivctdts. Ti»«
1 t«tw«a rvtitcaeat and dcata 0-1.5 r'
1 it groip 1 »d 2-19 yr. group II.
1 coatcals, agas »J-T2 re. »tt» Iln4 50
1 >i troa tba factory. 5*aia»w
t
| SMOCr; CJDJTIBS; ZIDIBTSt 1ITFI;
I HUBS; coRMiiTin zritDiTiofs:
{ III«STtIlt ITGIEHi msnXBNT
I iwaons: tvtiioti: Msmc:
I itu
                                                                                                                                                                                         o
-------
 tin
 TMO-31-S
Si
ati m.«9. n 331.9 e,  tt 2507 c,  TP  i ••
                                              »t  wio c,  10 •• 19 «t 18»» c
                                                                                    (COIIIiBID)
nasii


•06
HT.T





















aSOT
laag




















1
ixiosoti toon
















































IBUTTXCal
RETBOD

n






















BI






















BBRSSB
or cisss

) 8
t W





















•} 8
b( 19





















tuat


} < 0.3-3.18 ag/g
b) 0.3-3.70 eg/g
at «t




















a) 0.3- 2. 15 ag/g
t) 0.3-3.68 eg/g
fat *t




















B»B | GIIZSU XBPOIHUIOB
1
1
) lot givea 1 a) Coattol*
) lot girea 1 t) lockece, groups I and II
1
I Caeaaaed ret taerr and aaelter
| aacfcecs, aget 55-76 TC. expoaed to
1 keavy aetala 1-3 deeadee. Tlee
| batveea retireaoat aad doatk 0— 1.5 yc
I la gcoap I a«d 2-19 tr« group II.
| Ccatrola. agaa «3-72 yr. who U*ad SO
1 ka tzoe tka tactorr- s»«a«a.
1
t SUOII; CU1TCM; HDIITS; lim;
| IlieS; COBP1HTITB BT1101TICBS:
| IIDDST1I11 1JSIIIB: nUOIIBEIT
1 iiiBOBS: tniKiit usmc;
I TH.IH1IT1S; CIIIIOR! C5SCTB: CSIOBIDB;
1 CCBUT: conn: GOLD: HOB;
1 iimiBui: iiu: HKtBtss: incmi;
| BClTBOSIVBt IBOStmOtBS: «DU9T«>:
t SCIIDIH; simm: SIITIB; TIB;
1 ToissTSB: UK: asiin BIXUBS:
| IBPBSTBIll P11ITS ; SBSITBBS
1
a) Bot given | a) coatcols
bt Bot given I ti lortera, groups I aai II
1
1 Keaastd ref latry aad aaeltet
| acifcera, agaa 55-T6 rr, expoaad to
1 aaavr aatala 1-3 deeaiea. Tlae
1 tataeea reticaaeat aai deatk 0-1.S TT
1 la gcoap I aad 2-19 vc> gcoap II.
1 Controls, ages »3-12 ji. aao lived SO
1 *i froa the factory. Swedes.
1
1 iiiin: ciEtfns; HOTEIS: iir»;
I macs; comnmTS mimTioBS;
I 11DOSIIH1 BieilBC: BiaSOllIZBT
1 BITBOBS; miaOBTs USBBIC;
1 lllimni; CiDHTOB; CSSIOT: CEIOBIOH;
I cciui: co»a; COIB: HOB:
1 lllTBim; IUO; BlBGlBKSBt BElClTtT;
1 BoinpEBaa: IBOSWOIBS; BUBIDIOB;
l scininii SZUBIOR: SILTIB; ni;
1 IBBGSTBB; XIBCi BttlTB B1Z1IDS:
1 IMOSTBIll IUBT5: SUBIIMS
1
IStttSICI


Bcaae, D.
Bocdbecg, G.
Beater, 1.0.
1980
seieaee of tka Total
Eaviconaent 16:13-35

















Bcaaa> 0.
aoxAbeTg, G.
aestar, P.O.
1980
Scleaoe of tke Total
Enviconaeat 16:13-35

















                                                                                                                                                                                         VO
-------
Titallaa
1MO-32-C
II
It* »7.»0, It 1677 C. TV 3277 C, T» 1 U If at 2180 C.
                                                       10 •• Bj at 2*80 C
TISSUE EIKSVIE tons IMUTICXI
S PI BOB
»SOS
lott»
1
1 1
1 1
1 1
I
,,0,
Brain
1
1 1
1 1
1 «519
1 Br«th
(Sit
lair
i
Ittalaticn

n
n
i
i
I
put

xmm i ii*e* i BSII i eiiniL nromnoi I OTEIEITCS
or cisis ill 1
i i i i
t ll I
2 | < or • 2.8 «g/g (*«t *t) 1 t.< « or * 2.0 »«/g I »«!«« 1 T»ka»a, a.
1 1 (»«t »t) | » Saioltl-Taawoto, B,
1 1 | »ro« a 4»ap of «1 aatopslaa, 1 aaaao, K.
1 f | femtslc ladteal •xaainati.ODa. Japaa. I fatal. H.
I I | Balw naa *g» »0.6 jt. Paaalas, I 1*80
I | | ««aa ago 37.* TT. | Ireklra* of
III | t>Tlrona*ntal Hoajtk
| I | 111CZ ItSIZITS; aVTOPSIKS: JaPtl: I 35(1):3t-««
1 i i jioiiiDi: itstnc; CIDBIBB: COJU.T; i
t | | CtlOIIiri; COITIS; Ito>; BIICOII; |
1 i i ntxai; iinxstvi: uiamsx; i
| | 1 mniORs 1KIMR; SCllDISg; 1
1 i i SMWIOS; tnuiaii nuDtoi: me: i
l i i eciB; BBOsiH; IITXI; rrpiiis: i
I | | CIIJBSnlJ: CEMBKILVB; HUT; RVSraSS; I
I i f tucmss stittrt imss; ton*: i
I | | BCTU3: COBPM1TJTI CT1LOITI013: 321; 1
I | | TCttlSIC NDICIM |
1 1 • 1
1 1 II
1 a) »OB« d«t«ct«J | a} «oi« 4«t«ct«d I a) lain, cvnbraa, 9 iobl«ct» I Takava, 1.
1 b) < or « 9.5 ag/g («at I i>) •-> » or - C.7 I t) Taaalas. c«r«bria, 2 *obj«ets I 5anki-Tan*oto. B.
1 vt) | o?/g (>«t »t| | c) »«!•«, c 1.* os/» (nt | c) O.JS » or - a. 62 I t) remits, cer»b»lltia, S »ot1«ct« I Teral, B.
1 «t) | mg/g (»et nt) 1 1 WO
|t> < or • 3.6 aq/g (»«t ( J) 1.3 » or - 1.8 1 Fzoa a nconp of 61 «ntopsi«a, I a r china of
1 »t) | »j/q c««t «t) | foraaslc a*iieal axaainatioia, Japa«. 1 Inrlroaaeotil Bcaltli
1 f 1 Bales. MBD ao« ao.« ft. I«»alas, I 35(1):3«-««
i 1 1 i«an aq« 37.* TT. I
III 1
1 I | TMCt nniRS; aOIOISIIS; J»PH; |
I i i mania: itsnic: CJBSIOI: COBIIT; i
l i i cnoBioi; corm: cioi: BBBCUST.- i
1 1 1 I HITS; SKBISIOB; »«»S1IESI: |
1 i i igeioiDR; amsoir,- SCJIBIOI; i
1 1 I snnlDI; T1I1«IO»; MWPItJS: ZIITC; I
1 i i sen: Homi; LITZE: nottis: i
1 1 | CtSZBIO*; CtEZBEUDB; HBtRT; ROSCLXS; 1
I | (iVCBEIS: SPlEEIs 10KSS; 10ST1; 1
1 | anilS; C01P»I»TITI ETUVITIOITS; SBI; I
1 I fOEZISIC BECICIIE f
1 1 1
1

I
1 Wot glYtn
t

12.2 14 1 « 1 saapla4 at rat* of 1 1/aia, 2-10 1 lltMlaaoa, X.I.
I ala aftor tenlng • arc *«Ulaq rod a. I De»«4ela«r, 5.G.
1 1 Johansson, T.8.
1 Oai»erslt» pbraics stop, rlotlaa 1 Blcchoster, J.I.
1 1 1»76
1 KCBIDl; lEOtTS; 3RE1I8: CllCIHR; I inMls of Occupational
| CtlOtlfZ; CIWCIOI; COPPEB: I8OI; I BrgleM 19:225-23*
I IZIB; ntieiiESE; ncrst: POTISSWH; i
l Sturm; T«»nnn; TIUDIITH: me: JIB i
l foituTioi; nets; iiairsmu i
l iimsranzs; TBICS ELEBEETS i
< i
1 i
1 B«»ia». 2« Mpraeitatin I Ctittlaborougk, G.
1 Fr»-aBaljsls trcatmtc ar« | 1980
1 tabulated. Tba fMsiUlity of a I Science of tae Total
I kallstic. ao-«asa policr for kair j Zn*lra>Mat 14:53-75
I aaalTals la entllaod aad snppocted. 1
1 1
1 ff«TK; TMCt SIEKZtTS; Ha»: I
| JCSTBU.I1; 8USOIERER OTISODS: I
| CZTUS; fSOItnS; COMPUaTITZ |
| HllC»TIO»S; 1IDRXJVB; »IT1BOTT: 1
1 nsntic; EuivH: BBCRTIE; citBian: i
1 cueing cBiCBiii: CHSoaitui co ant: i
l ccrecs? sjiiros: sssniliiB: eon: i
1 ICDTIE: ttoi: nrrmiuB; LI»C; i
1 B»a»isns: BHG*IESE; SIBCOSI-. i
( tciTBDEni; ncKn: EBOSPBOSOS; i
i tcmsios; iminitjii; SSLHIOI; i
l stiicoi; sum: SODIUS-. snctrioa: i
1 SOITOB; TI«: Tninm: TVISSTM: i
I IIIC; tltcomH I
i i
tvm •««>


NJ
O
S3
-------
YitaBltS
TMO-J2-S
II
1W 47.99,
           HP 1677 C,
                         3277 C,  vp 1  M Bg at 21M C, 1O M Eg at  2MO C
                                                                                       (COimiTED)
TISSUE



Ml 2
Beart



















«S13
KUner

















a5H
liver

















posiitt tarns






























































itumcaL
RETROD























a



















Wat.

















BOBBSl
OF GUIS


4
2



















) 7
b) 2

















ml 11
•1 •<
h) »

















I1ICB



< or » 1.1 89/9 f"*
t)
•one ietected


















a| < or » 3.5 119/9 (vet
vt)
b) lone detected

















•t)
b) lone detected
















iin i 6>UML XEromTiokT
I
i
I
0.28 * or - 8.55 I •) Bales
9/4 |ve>t *t) 1 t) Peaales
»on« a«tect«a i
I ftoi a »ro«r of <1 antopsi««.
1 forensic •edictl «E»iiatieH, Japan.
1 Baits, wan « a«a «0.« re. r«««les.
1 f«aa aq« 37.* jr.
\
I fllCZ IL1HMTS; 1OTOPSIES; JU»;
| H.
-------
Iita*l»
7»W-3V«
11
Itl «7.tO. HP 1S77 C. n 3277 C,  TP 1 aa Bg at 21*0 C,  10  n (9 at 2«to C
TXSSBI
1*14
t
1... 	 	
Etposau toon
1
IIUTTICU
Btnoo
n
I t
(SIS la
Buelo
1
1
(
f
1
1
t
1
1
1 1
t 1
f 1
' . «
* 1
i «st7 i I n
1 Paacroa* I I
1 1 1
« 1 1
t 1 1
1 1 1
1 1 1
1
BKMEt
Of CISZS
a) 2
•» 2
1
1
a) S
b) 2
Mitt
a) < or - 2.7 »?/9 (Mt
Dt 0. 60* 1 S ag/4 (vot vt)
a) *oa« J»t«ct»4
i) < or • O.CS 14/7 (*«t
i
Biti i CEIIUL xiroiimo* i XERUICE
1 l
l <
a) 1. a * or - 1.» 1 a) Balaa | fakan, B.
tg/y (nt »t) I t) rmalas 1 Suaki-TaavBOta, B.
M 7.8 + or - 10 tg/g | I IBMO, I.
(»«t it} | Feat a groap of 61 actopsiaB. ( T»rai, B.
1 foraaslc Badieal «aalaatlou, Japan. I 1*80
| lal«B, a*aa ago *O.C Tt. rcaalae, f Irehlnc of
1 a«aa aoa> 37. a rr. I EBTlroB*a*tal Boaltk
1 1 35(1):36-««
1 ntCE ELtBtns; tBTopsras: Jirti; i
| linXI9B; IfSElIC; CUHIB; COBU.T; 1
l cnoBioB; ccmi: XKIB; sttcmr: i
| I1NTIB; BKBESIOB: BIK1IESB; |
| iHBIBIBS! IHXBOlts SCMBIOfl; |
l smiXBB; trnixm: TIIIBIOB; UK; i
| SCLB; SBOBIBt: UTR; KBIEIS; |
| CtlUBIB; CtiraELLOB; BXHT; BffSCLES; I
| PtKIMS: SPIEXB; 1OTSS; lOKTt; I
I BETUS; CO§PU«TITB BTaigitXCtS; 5BI; 1
I FOEBSIC BZeiCXIB 1
< 1
1 1
al roao aotoctod I a) Balo* | Takaaa, B.
») 0.08 + or - 0.23 | t) roBala* | Saxakl-Tacaaoto, B.
1 Iroa a groat of ft aatopslaa, ( Taral, B.
t faraaile BOdleal axaBlaatioaa. Japaa. 1 1980
1 BalaB, BOBB ago «0.« rr. rcaala*. I Ircklna of
1 aaaa ago 37.a rr. | EBrlrauoatal Malta
1 | 35(1}:36-M
1 TIICE ELSHEBTS: iOTOMISS; jaral; I
I »inBiim: IBIEIXCI CIBBIOB; COBUT; I
1 cnoBiira: corrEt: xioi; SEBCOBT: i
I MBim; BietESIOB: B»ISl»B5t; |
l loeiorjg; atrxBoiT; SCHBHIB; i
t tiannt ixmxm: THIDIOB; IXK; i
I eOlD; raOBXIE; UTEB; CIDBKIS; I
I ciisiKn: criESEtins; asm; HOSCLES; i
I MKXHS: SP1EEI; LHBBS; 10IT1; I
t BRalSi CORPIItTXfE iritOHIOUS; SEX; |
I rcmsrc BIBZCXII i
1
1 a| < oc - 7.5 ag/g (>ot a) 1.3 + or - 2.2 a) «at« I TBka«a. B.
»*> «J/g (»ot »t) t| r«a«l«« | sazakl-tasuoto, B.
b) < oc * 3.7 ag/g <««t •) 1.9 » or - 2.6 | liana, t.
•t| eg/g <««t »t> Itoa a groap of «1 aatopslos, 1 T«ral, B.
for«a aea 37.4 rr. | E«TiroBB
-------
TltaalM
7UO-32-6
Tl
It* 47.90. IF 1677 C. TP 3277 C, TP  1  M  Eg «t 21(0 C, 10 •• Sg at 24»0 C
                                                                                       fCOKIISEI))
TISSUE
4S1t
SBlM*

















iinsnx BOBTE



















1UITTICIL
SET HOD
SI


















mm
OF C1SIS
»» 5
b) 3

















11WSB
.
») < OX - 4.2 «J/9 («et
"t)
b) < or • 6.* «g/g t**t
•t)















Bill
a) 1.8 » or - 1.8
»9/9 !••* »*>
b) 2.1 * or - 3.7
•9/9 (••* »t)















EHttU IBTOIB1TIOI
a) Bales
t) f«Ml«

riot a.qcoip of 61 nrtop«i€«.
forflasic atdical ezaHlaatioo*t Japan.
Ral«. •••• af* 40. C TT. F««alea,
•tan a9« 37.4 Tr.

ttaCl niailH; aROKIKS; J»i«:
itmnns: iiswic: cuncs; COBILT;
CtBCSTOH: CCR11? IBO1; BIBCTOT:
HEitn; BESIISIOB: meansi:
iimivt; iRUoiT; SCMOIOI:
siiiiiBS: tiTMiim: muiaB; sue;
SCH; MOIIII: LXTSB; KIBIETS;
CEtlBSSH: CIBffltlLOl: RS1BT; HOSCtSS:
I11CBUS; SIIEEI; LMG3; IORTI-,
srriLS: coaeuaTXTi srixoitiois: sn;
TCttlSIC HIEICIII
BI7EEMCJ
Tnkava, B.
Suzakl-IasoBOto, a.
llano, I.
letai, B.
1980
trckiraa of
EOTiroaaeatal Health
35
-------
     lolvene  (8 CI)
     Benzene, (ethyl-  (9 CI)
     108-89-3
     C7-BS
     HI 92.13, HP -95 to -94.5 C. BP 110.6 C.  IP  36.7 u  Hj at  JO  C
                                                                                           (COBTIfVSD)
TISSUE
4521
Breath












EXFOSHIE BOBTB














IIU.TTICU
BSTSOB
SC-BS













HOHBI5
OF USES
54 (387
samples)












Bluer
lot given













•Ell
9.0 ng/1
Geometric












G1IEB1L IirOSBlTIOI
teasared at 25 C and 760 mm Sq
100* occurrence
tome and op pec one-Sign Units 4.0
and 17.7 ng/1

aealthr. 18-35 yr old, aoasiokiag.
orlan blacks and caacaslaai.
Chica^Ov IX. Higidlf controlled
€lp«rlaental conditions.
B811TB; 1XCCBQLS; HttBOIS; 1D51TS:
CBIOEIIJTM imtOUBBOSSi »OUTHE
CBGllIC COBPCO«BS: HB1LTH 1121805;
iiBiUTioi; arriBOLiSB: BZTAEOLITES:
Ecpnmrow imsvtE: VBBH mis
IEFIE5HCE
Krotoazynslcif B.K.
Brnnean. G.B.
C' 10 ill. S.J.
1979
Joarnal of analytical
Taxicoloar 3:225-23«








Iala«na-2,5-clla«ii«  (I CI)
1,«-BrazeiwalaiiM,  2-aethyl-
•f-TO-S
C7-B19-12
il 122.17. ITF S* C, B? 27* C
                                    CI)
tissiri
4522
urin»








IIPOSUSI Botns






1
1
1
1
I miTTICll
BETBOD










I BUB3SS
f OF C1S2S
1










I B1ICE
I
1










BE1«










GUIB1L IIFOBBlTIOf
(•Tie*. local and sr atomic effects
relating to hair dye floravlation.
iaqcedient tests* and experiences in
•ae and aflisals.

tints: Dis!»TTTis: IIOPIISBS: asiKE;
II TITBO 11ILTSIS: IB TITO 1B11TSIS;
BFTIB"! DIES; CIBCIIOGSIT; COSHSTICS;
GIBETIC fFFICTS; BE1LTS HlItBDS;
BITJ90IISB; jrrilOLITSS
BEnSEVCE
Karzalli, F.I.
Sreeo, s.
Haibach. 8.1.
1978
Journal of
CaTirOBMBtil Pathology
•ad Toxicology
1! 50 9- 530


Tolaener  o-nitro- (8 CI)
C«Biena,  1-iethrl-2-Bitro- (9 CI)
St-72-2
C7-«7-»-02
BI 137.1, BP -4.1 C, BP 222.3 C, TP  1  •• Hg at 50 C
IISSV*
»5J3
Breath












ElfOSVBE BODII














jtmniciL
BETBOD
SC-BS













BOSSES
or C*SES
s* oa?
siaples)












BalSE
lot glren













BE1B
3.040 s.g/i
Seoietric












Gr»iB»l IIFORBATIOI
Ceasnred at 25 C a*d 760 •• Bg
1». If accarreitce
Io»r and up pec one-Sigia lliits
0.017 and 0. 139 *g/l

B«althT. 18-35 TC old, non«»okt*i.
nt tan blacks aad caacisians.
Cbicatjo, 11. BioldlT controlled
eiptriaaatal coiditioas.
l*E»TB; IICOEOI.S; Illliois; units:
CttOBKMID HTDBOCIBBOBS; TOLITTLS
CBG1BTC COECOntDS: EE1LTI BllattCS;
1IBH.HXCB: BETtBOLISB: BE11IOLITIS;
ECPUL»TIO» EKMSmE: BSBliB IKEIS
IEF£1E>CE
Ecotoszynski, B.I.
Bcaa«an, 0.5.
e'nelll, e.J.
197"
Journal of Inalytlcil
Toilcology 3:225-2M








-------
Total BBC  (la porttaes  in
CS-BS-O.8
n 290.85
nssn

»52%
Blood













•525
PlaeeBta












'IPOSOBB BOUTB






























IBUTTTCal
BBT8OD
sc-BC














CC-BC












1
mass
OF CISBS
a) 25
M IS
e| 10












a| 25
b) IS
e| 10











la*GB

a) 18-85 ppb
1) 62-16S pp»
e) 105-550 ppB












a) 12-53 ppb
b) a 1-1 05 ppb
c| 31-134 ppb











BSaB

a) 52.5 * or - IS. 2
ppb
bl $3.9 « or - 22.6
ppb
c] 20». 2 » or - 141.2
p^ib









a) 2T.2 » or - 11.«
PP*
b) 62.3 * or - 13.4
ppb
c) 90.7 » or - 31.7
ppb








fiBKBlL IBFOBimoB

a) Coattols, fnll-t«ra pr«?n«ncie»
t) Pt«-teca pEegaaades
c) SpoataaeovB ibortima at laaa than
fl vie

EaaltliT* aoa-^xposedf prvqnaat voa9ii.
ages 18-32 yr, tadia.

IBCIt; IBOETIOI; U1ITSS HIOS;
HOOD; piicim: coniiswni
HUUTtOIS: CHLOBII1TED
«T9tQCMBO«S; CEIOBIII O561IIC
CCBP00B9S: KSECTICIDBS; PISrtCIBIS;
ttsticioi Eisioais; POIOI.KICI
IIJOS0BB; PIIGBIKT
a) Controls, fall-tera pregnaacles
t) Pra-tera ETeijiattCies
ci Spoata&coaa abortions at less tSian
3 >k (inclndaa fetas)

Bealthr* Boa-exiwaad. pregnant itoaan.
agaa 19-32 ji, India.

IlCIl; IBOETIOI; UILT3; FIUS;
ttltuillOKS; CBlomilTXD
BIDMCUBOIS: CH1OEIIS OB611IC
CC9KOIOS; lISICIICIIESi P1STICIDIS;
PISTICIDI BtSIDOES: POPDLllIOS
ItHSDlB; PBIGV1BCT
BEIBBEBCB

Saxena, B.C.
Siddiqil. H-K.J.
Setb, T.D.
Krishna Harti. C.B.
Bhargara, I.E.
KattT. D.
1381
Joaraal of lualftical
Toxicolo^T 5:C— 9






Sa-xena, B.C.
Si-ddiqti, 9.K.J.
Seth, I.D.
Krishna Bortl. C.B.
Bbanjara. l.K.
KottT. ».
1991
Journal of Inalrtical
Toxicology 5:«-9





                                                                                                                                                                                             K)
                                                                                                                                                                                             VD
  Ictil rot  (lo paaUiiqs In CRHIIICI.
  '9-M-3
  C1»-B»-C15
  B< 35*.50
iisstn
»5»
Utpow



















IIPOSOM BOOT!





















IHinlClt
nrraon





















ITWBTB
OF CISIS





















BtVGt





















BMl





















«I1IB*1 IIFOBH1TJOI
B«»ie«

Iipooed persons la the United States,
tfe« «»tli«rlajiis, SxnJati, Israel,
Japan. OSSB, Polanl, Servaaj, laiia.
Ellqacla. P*klstam, listrio.
Eipott*! «a««» at liTpettemlsa,
e lava ted satoa cholesterol^ abaoraal
•tea, oc iafaltaaat of Bcncoanscnlat
fvtctLoa aftac acnte «xpoa«ce to
eoabinatloat of pe»ticilea, tat mast
data ski" DO alters* «ffecta after
loaorteEH occnpatioaal ezposate.
insruri: ITUGUX*; ctsBini; IIDU;
ISHBl! IIP*!: IETBSELIWDS; PISISTII;
ICL1ID; BDSSIl; Stntf; nllTID
Sims: IBIPOSE nssni: BLOOD: BIOOD
ffllSfia; 5ICCD SlSHi: KtTIBSOCTTES:
nvKocms; eiu; VBIBB-. sinis;
flll-H B1Z1BCS; OCCOP»TIO«I1 B1UBDS;
fcfiimo* iieosoi:
IBTEEZBCE
Oeichaann, V.B.
HacDoaald, I.E.
1977
Vcotoxicologr aod
Enflroaaeistal Safetr
ljM-110















                                                                                         («!IT PUS El
-------
lets.1 >DT (*e postieqs U cmttnt.
50-29-3
CU-B9-C1S
II 3S4.SO
                                                                                      (COfTtWOZOl
1
1
1
t
r
r
i
i
i
i
IHJB1
•527
imlotic
flald
•528
Blood
1
1
1
raposun IOOTE

t
isaimcu
Bx-YHGO
OC-EC

i
>SM I
I Blool, |
I plassa 1
1 1 1
1 1 1
t 1 1
1 1 1
1 1
1 1
1
1
or cuss
50

20
suet
O.S-26. * ppt

•| lot oirsn
b) lot gives
Bill | GBIItll IfrOtimOI | HntmCC
1 1
1 •
1 1
23.83 ppb | *3 positive ipeciseas I saxea*, B.C.
Seoaetric I 1 Sett, I.D.
1 reeosaat meo» sisilax ia f Bahalaa. P.I.
| ««cioeea*o*ic level a»fl dietary t 1*80
1 bablts. Xo occnpatlosal or 1 lateraational Joarnal
I acclaestal eipossre. lockvov, India 1 of Eoviroisestal
I I analTtical Caesisttr
| F1SHCIDBS; CBLOIKUS9 HT9IOC1XBOTS; 1 7:Z«5-25»
I CEIOJIBJ CICIRC coapooiis: cop; 001; i
I en; unit: HBGHICT; «B«IOIIC i
1 iioiB; mcmt i
i \
1 fevlm I Delckaaim, «.«.
1 1 BtcDosaU. *.t.
I Opond persess la tke Halted States. 1 19TT
I tke •etaexlaids, S«e4e>. Israel. 1 teotoxieolotr and
I Japan, VSSI, rolaad, Oereaaj, lodla, t EnviroaMatal Safetf
1 Bulgaria, Paxlstaa. laitria. 1 1:89-110
| 8«Fort«i eases at trperteaslas, 1
j elevated seru ekolesterol. abnoraal I
j M6s, or ispairaieat of Besrenflcel&r 1
j fMctles after acate eipoaara to 1
1 cosbiaatloBs of pesticides, bat sost 1
j dats skos no adverse effects after 1
I long-ten occapatioaal expossre. I
I 1
I KST»U: BDteiiii; eniiii: acin i
1 isian.: J»P»I: nitnims; tuzsttts 1
I idiHi; snssn: SKDSi; mm i
I STH»S: IDIPOSZ Ttssm-, twos; ILOOD i
i ztorocftes; ait: viat; iifisi; ' i
| EMITS B1X11IS; CCCIPJlIIOIU. R1IMDS; 1
1 tcpratno* Mposait; SSOPLISBS; i
1 flSTICIOIS; CHLOEIBI OIGIIIC 1
I CCBPOBIOS |
1 1
1 1
a) 38.18 ppb 1 a) Ixposed I Bich*rd*oB, J.I,
b) 6.69 ppb 1 t) coatrols 1 tell, J.I.
1 1 SaBdlfer, S.B.
I 8*g Croa Soatlt Carolina Pesticide 1 19T4
1 St>o> exposed to slxtare of CDT, I F»rltoae»rtal 7e search
1 patatkloa ail carbaryl. Controla. 1 9:290-29*
1 with so knevs pesticide exposure, I
1 tatc««l «itk exposvl aroip fox aie, |
1 race, sex at. 1
1 <
1 slqaif least correUtioas of tot 1
I elevatioa asd ckoliaestersse 1
j depreaslon vitt elerated svatollc and 1
1 dlastollc blood rcessares. j
I 1
I SCOT* cMoriii: IMOB PUSBI; DOT; i
1 flSTICIBSS; BZI1BOUSR; OCCDPaTIOItt I
| llfMDS 1
1 1
                                                                                                                                                                                         VO
                                                                                                                                                                                         CO
-------
total BDT do pacttio* la CI1BLIH}.
50-2*-J
CH-W-CIS
(1 35*.59
   TISSVt
   530
   laofl.
   •S31
   Hacctta
             mason torn
  lxa»-t-toMMl  tie
                RMsm ion
                                  RCTffOD
                               ac-cc
                                                   IDS BIS
                                                  OF CASKS
                 ppb
                                     200.91 ppb
                                     Go ow trie
                                                                                                                        esitui
                                                                                                               lipowd pcncas la tk» ttitcd States,
                                                                                                                      US*.
                                                                                                               Filq«rl«, Patlitn,  lastci*.

                                                                                                               l« portal cas» mis
-------
1-TTTPtOpaaB,
<350-«9-8
C11-B 12-12-03
•« 220.22
            S-fcrdrorr-. I- (8 cq
                         (9 CI>
TISSUE
• 513
nood.
plasa*















EIKSnBE 10OTI
IlJeetlOB
inaestloB
















1I1LTTIC1L
BBTWJB
•PLC
Flaoroaetry
















BOBBxa
or ctsss
5

















BU6E
a) 2.3-0.29 aioles/T
b) lot gir«n
cj lot glvea
d) lot gl*ea
«) BOt gives













nil
al 0.97* » or - 0.068
naolea/1
b) 3.25 naoles/1
c) S.SO taoles/1
d) 7.81 uoles/1
e| 11.00 moles/1












GJMBIL mroiuiioi
• 1 lBlti»l •«aaac««««t and 9 hr after
24 (in IT of 0.908 iwiles/lcq.
tiexpowntial decline. leai is 9 hr
tiM-average
11 50 aq doss
c) 190 «a dole
4) ISO •? dcae
<) 200 mq doee
b)-a) 8 ir tiae-arelsge a«ias
c»pited fro gcapkie
at«»-»n4«r-t!»-ciirT« data aftec oral
dose/* ar
H-S2 TC aide, *t 52-»6 k«, nitk
ifocloiie disorders.
**asea. rorltlag
CBves; BBUS TBEIHT; mvo ICIDS;
iioao Ptisai: lEtraososctniR iisnsis;
leans; DIIRUK
1EFEBEIO!
lagaissea, I.
Ilelsea-Kadsk. F.
19BO
Acta Paaraaoologica et
Toxlcolojica «6: 257- 262













Tvnvsten
7»»0-33-T
*
It* 183. 85. HP 3«IO C. BP 5900 C. TP 1 •• 19 at 3980 C, 10 •• Hg at *«90 C
1 IISSOI | EtrOSDRS BOOT! | IHtTTIClL | KOBBIB | EitGE | BB»« | 6EIZBIL HFO8BJIIIOI
1 I 1 HETBOD | OF CIS IS | j
1 1 - 1 11 1
1 t f 1 g
1 *53' II II B€Tlew. 2« npreseatattve
1 "air || II cie-aaalrsls treataeats arc
II 1 II tabulated. The feaxibiUtT of a
II 1 II holistic, ao-vash policy for hair
til t aaaljrls ts oatliael aad supported.
Ill II
III 1 t tiriSV; TP1CI ELZirEBTS: HUB;
III il Ktsmtii: Hzis«E9en HBIHODS;
lit || FITILS; P SOT IMS: COHPlBlTlft
111 II IflI01TIO«S; ItaniOB: IBTtHOlT;
III 1 ISSEIIC; BIRIDI; BBOirJS; CIBSITC:
1 1 1 1 I ClICIOI; CIIOBIIE: CHSOHIOS; COB1LT;
I 1 I 1 terra: SHIIBH; sBsmnirs; COLD;
1 1 ICBIII: IEO»: L1ITI1BDI; IE10;
1 1 BIOIISIITB: BiRGiiEsi: iiscosr:
1 (ClIBOSIBB: HCKrt,; IHOSPSOSDS:
1 ECTaSSItlR: BDBIDIJ9: SBXEIIOB:
I silicon sinra; SODIOR; SIECITIOJ;
1 sin FOB: TI>; TITIUVI; TDIGSIIB;
1 ziic; TiBCOBinn
f i
{BEIT PIGS]

BMI IBS C!
Caittlebocoagfc, G.
1980
1 Science of tie Total
1 EETlcoaaent ia; 53-75

U>
o
o


-------
Illgstm
7440-33-7
*
lt¥ T83.IS, IP 3*10 C, BP 5»00 C, TP  f »  Bg at 3*80 C, 10 II Sg It 4490 C
                                                                                       (CORIIIBD)
ixssm
453*
KlSaeT
4S3«>
li»»r
4M7
MWI
fosvn toon



iHlTTlCAl
sntoa

n
»
DBBD
CaSSS
e
i«
S
19
*) «
b) 1»
1
1
MISS
< 0.003-0.005 v?/9
< 0.003-0-018 *«/«
t «t
1 < 0.003-O.OM oq/q
I < 0.003-0.01* 09/q
•t wt
•) < 0.043-0.011 09/4
b) < 0.003-0. 15 ng/q
let lit
	 iHi 	 i sBijiai iiroMaHoi t ssnstics
! !
i i
*>t gl»B 1 •) Co»trol« 1 Br«i«. D.
lot SiTO 1 V> lotlnts. groups I aad II 1 lorlb«ra> s.
1 | vester, P.O.
1 t«c«s«l refiBcrr »»« aaeltar 1 1980
I «rt«rs. a»«« 55-7S jr. siposed to 1 Science of the Total
1 lurr Mt*ls 1-3 a«c«d«a. 11» 1 ICTiconwat 16:13-35
| ltt««» catlm«*t **i Amtk 0-1.S yc I
| 1» qconp 1 nd 2-19 yc. ?rfl«F II. I
| Controls, a?«s 43-72 Tt, (to liwd SO 1
1 k* troi th« f«etorr. 3>«d«i. 1
t sum: cimtiBS; Kioirrs: IITIB; i
1 HISS; cospiiiTin snigmois; I
i iimSTSiit ixeiiRt nasnumi i
I inwus; niiBOii: usnic; I
t mumivB; c»BBJ0»: css:q»; csBo«0B: i
1 CCIU.TI cotni: GOU>; noi: i
i iiiTnm: tuoj lurainss: nicnsi; t
1 KinDBflfl: fBOSPBOIVS; IVIXDIOB; I
1 sciiBius: SIIMIBS: SIIVEB; ni: I
I ivissni: line: HUITH BKIBDS: i
I J1BB3TSIU JUITS; SBHTM3 1
1 !_._. _
1 1
\ lot 9iY« | *t co«*toli 1 Braea, B.
) lot 9ii«» 1 t) laxkers. groups I »»4 11 1 Borlbcrf. 8.
1 1 l«st«r« P.O.
1 t«c«»»4 r«f i»err ••» «Mlt«r 1 1980
I ictlmrs, ««•« »-7« rr, expowi to 1 Seine* of tie Total
1 kMiT Mtalt 1-3 awnfla. Ii»« 1 rn»iron«e«t 16:13-35
| t«twn tetim«t w4 4«»tli 0-1.5 jr I
1 i* qroip I »4 3-19 IT. group II. I
| Cotrola, «9« 13-72 rr> »'"> liwi SO 1
I k* fxoi tk» tietorr. SvelM. 1
1 t
1 SIZDMt C»»>«SS; Utinsj 1IT5BJ |
I itics; omrumn miaiTiois: i
I mvstiiai iiaitis; asaSDiiinr i
I CKBC9S: \irimn; usnic; i
I ttwniaa: caDangi CISIUB: CRtonvi); i
I cceiLt: comii SOLD; noi; i
1 laming: »u>; si»s»«si: HMCOSI: i
I tctnosmn! uoswoiust BOBIDIOH; i
1 5cmim; SHMUJS: sn«i: TI»: i
1 t«iesn«: IIK: HUIIH BIZUIS; i
| IlDOSltlal Pims; SBBITB*! 1
> 1
a) lot 9lT«n I *) Control* 1 Bran*, t.
t) lot alven 1 t) lotkets, o lima 50 I
t ka froa tk« tactorr- Sveiea. I
1 1
| SKDEI; C»»IES: (ItltTS; 1ITSS; |
t taies : coataUTin r»n.uiiio»s: t
I IlCDSTBIaL BTSIBIB; aEaSOHIinl 1
1 BtTBoos: UTUQH: »snic: i
1 Ttmrans; citRios; cssrnB: CBBOBUJH; \
1 cciui; COPPIB; SOLD: isoi; I
I tllTBlim; ItaD; 141MIES2; BMCTIT; |
1 sciTBOMOB: iBOSptoms: BOtlBias: 1
I SCalDimj SI1NID1; SILTE1: nit; I
1 tnisaiEi-, me-. BUMH aiiisis; i
I iBovsniti IURS: SIBHZIS i
i i
-------
  mulu
  7MO-61-1
  I
  Itl  238.029. IF  1132 C. B* 3818 C. TP 100 n 8g tt 3270 C
IISSJS
• 538
Satr

HMSBBE iOBTB


• B1LTTICU
HSTBOft
n

man
or cisss
5

I1I6E
0.25-10.4 ag/g

mi
lot gin*

esiiBii iBFOBBinoB
Eilk hair sasTlB*
lector* exposed iateraltteitlr to
aiaalea at the laxtraliaa atonic
E»rgr Co»»isslon *e*eacck
establishment.
iBsraiixi; Bin; ramos; BiisnnBnr
MXBOBS; OCCBP1TXOIU BaillOS;
iiBXOfoctnis: iBw>5T»i»i aioiii!
BEFEUBCX
san tier, <•'•
vr*tt, J.B.
1»60
iBTiroaseatal Besearch
J1:»07-«15

VaaaUas
7»»0-62-2
T
Itl S0.9«1«, Bt f»17 C,
                          3000 C. TP 1 •• Bg at 2290 C, 10 u Bg at 2570 C
1 IISS1S 1 BXfOStm BOOIB IMLTTICIL IBIiffl 11T6E
1 I BRHOD OF CtSSS
1 1

1 

TI1CE tLHIBIS: 1OTOPSIKS; J1P1B:
IIDBIBVI: ItSIBICi ClSniTB: COB11T:
CBROBMB: COPPEB; iao«: BIBCOIT:
IIBID9: IllSIISIOB: B1B61BISB;
IDEUIQI; 1BTIHOBT: SC1BDIOR;
SfLEHIBa: IITMI09; T1MDHJ9: flK:
SC1C; BIOBIBZi IITSB; KIBIBTS;
CIIIBiaii ClHBHLOBi HEIST; SDSCLIS;
F1BCXI1S; SFIIBB; 1VBSS; 10II1;
BII11S: COBFIUTITE ZTlt01TIOB5i SEX;
FOIIISIC BEDKIBE


Siblects froi 17 collection cites IB
the o.s.

SIIBBIBB; BCirBOSTOB; TlBlDIOB;
EIOOB; SSI) SOUTH DlKOTtj III TOBK;
ITCBTBC; BOBT1B1; OBIO; BISSI5SIPPI;
| | THIS; BOBTB D1KOT1; 11SHUGTO1;





a) Bot given
b) 0.0*-9.33 og/g (»«t
•t)
c) 0.03-0.23 ug/g (net
«t)
it 0.10-0.31 ag/g (vet
•t)















| CIllrOBJH; IB IIOH: ISDIIII;
| ICOIStlBl; 1BE1BS1S: TIOBID1:
t
1

riBBOBT; TMCB CIBIUTS


a) 0.11 * or - 0.09 | a) Bales, eoEebcM. 9 sableets
ag/g (vet «t( I 1) Faaales, cmkmm. 2 sabjecta
b) 0.18 • or - 0.21 | c| Bates, c*rebella>, 7 subjects
"9/9 Cet *t) | d) Feaales, oerebellas, S sol-)ecta
c) 0.10 * or - 0.06 1

og/g (cat *t) 1 Itoa a group of 61 aatopaies.
4) 0.20 » or - 0.10 1 forensic M4ic*l ezasiaatiois, Japan.
•g/g (net vt) I I
1 a
1
ales, aeaa age ao.S yr. Pesales,
eaa age 37.4 rr.

1 tElCE niBtlTS; IIROPSISS; J1P1B;
t IIBBIBTIB: JSSEIIC: ClDalOB; COB11T:
1 CBBGBIOB; COPPBB; ISO*: IIBCDXI:
1 iBcint; B16BISIQI: BIBSHISI;
1 latlDIQB; iniROBT: SCimiB;
t «IIJ»IOI1: TITMIOB; T1I1DIUS: II1C:
1 SOLD; B30BJ1I; 11TSI; KIOBtTS:
I cisiBsns; CSITBILLUI: BBIBI; EDSCLIS;
1 menus; spiral; LUSGS; icm;
l i
niLS: CO«S»I»TITI ITU.BHIOHS; SBI;
1 T01IBS1C BIBICIK
1

*EFE1EBCI



Tndan, B.
sazikl-Tasaaoto. B.
Icaio, I.
feral, B.
1984
Irciiies of
BBTiroaaentll Bealta
35(1):36-*»












lllanaT. I.E.
Kobota, J.
losee, t.
Eotb, n.
1968
ircalres of
EnvlronsaBtal Health
16:3>2-3«B




nkavav B.
nznki-TaSQioto, I.
saoo, X.
erai. B.
980
rchires of
EsTirotuatal Bealth
5(1):J«-»4














(«« tkSS)
                                                                                                                                                                                        o
                                                                                                                                                                                        ro
-------
faaafllaa
7«0-«2-2
             BP 1*17 C, tl 3000 C, TP I an Bg at 22*0 C,  10 is Bg at  2570 C
                                                                                      (COITIIKD)
nssra
«»j
Breath
MM
Bair
»SM
H»lr
W5
n*ic

MSVIB tOOYf
tUtLom




tlURICM.
BRBOD
I

n


BBBBS i MKS i mi j ouiiu nroiimoB i IIRIZICI
CiSKS 111 *
1 f 1 - - 1
114 1
1 lot gl»e« 1 0.7 if 1*1 siielrt at rat* of 1 1/sla. 2-10 1 IfcselMOS. K.E.
i || ala after bsrsing * arc nltlng roil*. 1 Desaedeleer, 6.6.
1 i i tun detection linlt. | Johansson. T.B.
Ill | Binchester, 3.1.
i | | BnlrersitT rhysies shop, Mariia 1 197«
III 1 annals of Occupational
i | | noiIBl; IBBIW: mini; dicing; 1 Hygiene 19:225-2J«
I | i caioBjBJ: ctaoaioas conns iiois i
I i i mot BI let 1KB; nun.: Krtissiw; t
I i i SBirm: iniHOH; TtuDioa: me; »i« i
i i i tcumoB; imtst mvRim i
I i i mosMHBS ; TBJCB niBiits i
i i i •
I I i »
It 1 a) lot gim 1 a) ft. 04 + or - 0.01 I a) Controls, at blttt 1 eib»o». S.S.
H | b) »ot giv«* I aq/g 1 *) »»ll-t«ri lo* birthMjght, at I Dcvolf*. I.S.
12 | e) Mot glT«B l b) 0.0» * or - 0.02 I tittk 1 1*80
11 I 41 lot glv« I «9/g 1 c) tr*-e«tm. »t btctk 1 »mtrition B»port«
It I •} «ot jlT«m I c| 0.01 « or - 0.01 I 4) Controls, 3 ao 1 Int«raa.tloo»l
10 I f) not 9i»«a 1 •«/« 1 •! rnll-t«rs lo« Birtkmlgkt, 3 so 1 21(3) :3«1-3«9
I |4) 0.«9 * or - 0.12 | ft tr*-t«rs, 3 so I
1 1 «9/9 1 **41ans » ot - SIB 1
| | •) O.S» * or - O.sa | |
I 1 i«/g 1 Konatos In lallfal. fco-Mn froap 1
| I f) 0.22 * or - 0.1* | scan Urtfc*«igkt H80 g. 24-3C rt I
1 I *q/9 1 gcttetloi, l«ll-t«ri lo* birtbnlght I
1 | | group a*an blctk *«l 0.036 ng/g 1 b) Klti pie sderoala patients 1 Bolibecber. J.
1 I aeALans I Sasfles fron 7 scalp sites in each 1 Stuart, B.C.
i i | sabjeet 1 1*7*
III | Clinical Cbenistrr
l | | CltlBl; JOB1TS; CltTUL RBTCOS I 2»(11) ; 1996-2000
1 | i IISTH oistiazs: atn; uoBitoa; i
I i i item*; ciicnjB: cnion»: cop;»; i
1 i i setts Tooiit; BiiemsB: BIIU.SS i
1 i i sitinmit siiTiB: sonoa; soirtus i
| | | 11BUIVB; tlBC I
--,,,-.» - ' ' '
III 1
j j j 1 rerie* ef irarld literatue on the | Jenkins, B.I.
1 | I accaselatioa anfl bioooseeatratlon of 1 1*7*
| | | aelectea toiic trace setals in hsnan | ZTl-«00/t-7*-04*. 1*4
1 1 1 hair «»4 nalln a»4 other saanalinn 1 pp.
| t 1 hair, far, nails, cla«* and hoofs. \
I | 1 Tabalated ri geographic area, I
I I 1 aabjects, sex, age, exposure t
I 1 1 gratiest, analyses in ppn, and I
I | 1 aathoritT free over 400 references. 1
III 1
| | | IIIICl: lOSTIUIl; CMIBl; CIITB11 |
1 i i mild; ruscpE: noun HST: «f i
| | | ttllllO; SOQTB UnlCk; SOITBEIST I
I i t isii: oiRiD KIKDO*: anno sims: \
| | | 1111: milS; BETIEB; 1ITIBOIT; t
l i i itstnc: BoioB; CIDBIOS; CIBCBIOR; i
| | | CQllM; CC??H; »»!; BCTCOBI; f
l ii iicKBit snBinits Tilt Ti»ionnij KB i
1 | | rciirtiof: kilBii POTOUIIOIS; |
I | 1 EICkCCOBIIkTIO*; SIOIBBICkTOBS; tlfl 1
1 i i EOIIOTIOI; vopvimoB zxposni; *un |
| | I tCItlTlOl; ISkCl HIMWISJ HITklS 1
1 1 1 «
(Bin p»oi)
-------
7a»o-SJ-2
t
it* S0.9»i«, BP 1*17 C, B» 3000 C, TP 1 aa Bg  at  22*0 C.  10 aa Bg at 2570 C
                                                                                      (COIIXBOXD)
I
1
1
I
1
1
ItSSWS
•s»«
Hurt
«1«7
Miner
1
1
1
(
EiMsms loan

iBimxcu.
BBTHOD
•1
it
(
l
l
r
i
i
i
1 1
I as*« 1 »
I Lira 1
1 1
1 1
f 1 1
1 1 I
1 1 1
1 1 1
1
1
1
1
imia
or cuss
a) *
M 2
•1 7
hi z
l
l
1
MISE
») O.Ot-0.1* ej/» (»et
»t)
b| 0.21-0.23 ng/J Net
«tl
•1 0.08-0.22 04/9 <»•*
«tj
1 lot glT«»
a) 11 a) lot gl»«n
b) 3 b) lot gitea
I
BUB i 	 	 etiEtii xirotsAiioB i KTMBBCE
! . .»
i i
») 0.09 « or - 0.07 | .) Bales 1 Tofcm, 8.
ag/g (••* «t| 1 IJ Pnal*> 1 S«Mki-raa«K>to, B.
b) 0.22 * or - O.Ot | 1 1BUO, K.
aj/g |mt *t) f fro* * ?roap of 61 Mtop»l«», 1 T«r»l, g.
1 tactmalc ndical «»*ia*tioi*> Jap». 1 1*80
1 Bilu, M» •«• «0.6 tc. Ttralma. \ IrchlTM of
I MU »« 37. • TT. 1 EDTitOlMBial S«»ltk
1 I 3S(1»iJ«-»»
I IB1CI EltBIBTS: JUIOPSIB3; J1F»; I
1 JIDRWHI; 1BSXIC: C1JBHI8: COBU.T: 1
1 cBtonvB: coTTtt: »oi; BIKIBT; i
1 iBentB; BicitsiM: Bueutst; i
l BVBIOITO; imBon: sciroioB: i
1 sntmii: TITUIVV: TIHBIBS; 2i»c.- i
1 C01B; BtOBIIf: IIIEJ4 nOIZTS: 1
1 CIltBtVB: CIHBEUBB; BBllIj IVJCLBSi 1
1 tiBcius: siiBBB; vnest IOBTI; i
I B JlltS; COMIBlTira lTUtHTIO»S; SKI; f
1 MBnsic BinicHE t
i i
U 0.13 * or - 0.05 | •( «»!•• 1 T«k««, B.
•9/7 (••* •') 1 t) I««»l«« 1 Sunki-TamHto, a.
W 0.02 * or - 0.03 | 1 Uaao, (.
»g/g f«»t it) I ttoi a qro«p of «1 »«top«l«», 1 T«r»l. B.
1 fomslc wdlcal •i*aiDttio«a> Japaa. 1 1*89
1 1>1«, M** a«* 40. « Tt. r«ult>, 1 archive* af
1 M«a •?• 37- • re. t C*Tica*M«tal Bvaltk
1 1 3«{1):3t-M
l TIKI rttatns; kmorsitst Jam; i
1 IlgBTBUB: IfSniC; CIDBIDBI COHIT; I
1 cnoaius: ccrrsBs r»o»: BMctar: I
1 1BOIOB; ai«BisioB: stieitist: i
1 IOBIDIDR: IIIIBCBI! SCUDIDI: <
I 3nmvi: TITIVIOB; miDloB: intc: (
1 eoiB: gtoiiM: urn: HDICTS; I
1 CI1BBS3S: CSinilLIB; 9U11; JUSCltS; t
l imctMS: sriitc lotss; »OMI; i
1 «tI«lS: COBMB1TITZ ETIIOMICM; SEI; 1
I 1C1IBSXC SJOICIH I
' '
a| 0.12 » or - 0.07 | a) Bal.a I Tnk«»«, B.
nij/g (>«t «t) I t) !>•»!•> 1 Sazaki-Taavaoto. B.
b) 0.09 • or - 0.12 | 1 »«mo, K.
ua/g (vet vt| 1 Fcoa a gcoap of 61 »top*i<», I tecai. B.
I fcreasic aedlcal ezaaivatioav^ Japan. I 19BO
I BalM. aeaa age «0.« re. r«Mles. I lzeki**« of
| i«a» age 37.4 Tt. 1 iBTiroueiital Health
I I 3S(1»3«-a*
| II»CI ntBEBIS; 10TOPSIES; JlItB; I
1 iimBiB: Msraic; ciosioi: COBU.T: i
| COCBIDB; CCfPZt; IJOI; BllCDIX; 1
I IICKTR: HteilSIVB; B1BS1BISE; 1
1 loexottn; amioti: SCHDJBH; i
1 srusins: -ritinoi: T«»IDIO»: inc; i
1 60I.C; BtQHUf; IITEH; KXDKTS; t
t ClBtBin; CniBEUOB; HX1BT; BOSCLKS: I
I IIBCMtS: 3*UEB; IVBGS; aOllii 1
i B1TUS: COB»UMITS CTHHIT1OMS! S
-------
7««0-«2-2

T

Btl <0.9«|a, m 1917 C, B? 3909 C. T» 1 aa Hfl  at 2290 C,  IO M Hg at 2570 C
                                                                                      fCOIT»1)ED)
ISSBB
4M9
IM*
»SM
Bvael*
»5S1
1*11
wstws ionic


1
i
1IU.TTIC1L
reraoD

*

man
r CISBS
2
j
> •
) 8

I1KX
0.10-0.24 ng/9 (n*t
1
0.08-0.09 »9/9 (wet
)
) 0.03-0.22 ng/g (mt
t)
) lot giT«n

•HI I 8EMU.L nroiBlTIOB | HFESEICE
1 1
1 1
O.t7 * 01 - 0.10 1 •) teles 1 Takata, B.
q/g (««t «t) 1 t) T««»la« ( Snzakl-nmioto. 9.
0.09 » or - 0.00 I | AMBO. I.
g/g («at vt) I »to« • gro«p of 61 aatopsio*, I T«rai, B.
I forensic Mdlcal •xulutioi*, Japan. | 1*80
1 Kl«>, MU a«* *0.( it. Mnl«s. I iccbl»ea of
1 MU »q« 37.a ft. | loTltonMatal B«altfc
1 | 35(1):3<-*«
1 tucB iLinns: IDTO?SISS: JiPii; t
I U»mi; IRSBIIC; CUIXTU; OOBILT; I
1 cnoBtM: coppisj not: nmR: i
I IllIVB; HKIESIVB; BUGUISI; (
I BKIPtVI; iniROR; 9Cim«l; I
I snnigB; tinsinu: nnoiVB: 7i»c: i
I MID; B10BIM: LITIB; KIDIIIS; I
I cHiBioi: cuKBEitoB: aiiBi: IBSCLES; i
I fimtis; seuzi: 10193; lam; i
| BEtkIS; COBPttlTXVE ETU.01TIOIS; SCI; |
I fCSZVSIC BIBICIIE |
1 1
) 0. 12 » or - 0.09 t •) •«!" 1 tnk»a. m.
vq/g {net «t) | 1) T«al«a | Saxikl-Tanaoto. B.
b) 0.11 » or - 0.06 | | anno. «.
aq/9 («et «t) | Itoi a gtatf of f 1 »»topal«a. \ T*ral. B.
1 fot«BSle wdtcal «iaaliatio>«, Japai. I 1980
I Ial«a( M«B *9* «0.* jz. r«ial«a. I Ircfciica of
I *«aa aq« 3T.a jc. | lB»iron»«»tal Health
1 1 35(1):3C-«»
i i«»cs nsims: amofsus: «ni; t
I iiniinii: nsnic: ODBIOB: COBU.T: i
I CJioamst coptci; HOI: BIBCJBT: i
I iitioB; aisiistoa: uieiiuz; i
I iiBioioa: iniBonr: sciiomsj i
1 siinnia t muna: TIUDIHB; trie-. i
I eciD; BSOSIII: ixvzi; nniiTS: i
| Climai; CZIIBCUVB; BE18t; BV9CI.IS: I
1 tiiCBtis; spini; IOKS: iont; i
| AE1U3; CO^PIWTU! IT»10»TIO»S: SZI: 1
1 fciime BtgiciiB i
1 1
1 1
1 1 tnlm el wnia litvratnr* on th« I J«ikl*s. B.«.
1 aec«»alatloi aa4 bioconcentritlon of | 1979
I ««l«ct«4 taite tcac* Mtala IB taa»n | EPl-tOO/*-79-0«9, 184
1 kale aa4 Dal la sad otb*c aiaaalian j pp.
1 talr, f«rf >aili, cl»s and koofs. 1
1 fab«lat*4 tT qvoqrapUc area, |
1 *abj«cta, s«x. aqe* oxposart 1
1 4cadl«Bt. aialTBos in ppa, and (
1 aitkocitr fcca over too r«f«c«Bcea. i
1 |
1 ItXICl: IDS! Bill »: CMlDl; Cllttll \
\ letllCi; SD10PZ; BIDDLE E1S1; III I
I tittin: sooia iBCTici; SOOTBEIST i
I »«»: DTI1TZD (MGDOBi OJTTED STIIES; (
1 BUB: iiILS; tzTin; tmaoiT; I
1 itsmc; BOEd: cioaiaa; cajcnim; i
1 CCBIIT: ccppiB; izii; HIBCOBT; (
1 iicKtLi snciruii: TII; THIIDIBB; ME i
l iciimoi; nniL posoiniois; i
1 ticicco!iTiHT:o»: BIOIIDICITOIS; LIVD I
1 tciionon: rorotiitoB RPOSDBE: 9»tie i
t ECltOTKM; TUCE ZLBBtRS: BIT 1 IS |
1 1
(BEIT PlGE) " "
                                                                                                                                                                                             o
                                                                                                                                                                                             Ln
-------
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a. 532
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i
j
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unit
or cisss


a) 5
b) 2



















) 5
M 3










met



a) 0.06-0.15 19/9 I»«t
•t)
b) 0.11-0.23 «9/9 (Mt
vt)

















a) 0.11 19/9 (»«l «t)
) 0.07-0.23 «9/9 [»at
tl












i
i t
t i i
BI»I | GEIIUt IirOIIinOI
1
1
1
a) lot 9lm I a] Ial«*
til O.IT t at - 0.09 ( t) rntloB
•9/9 (V*t »t| |
I I Eoa a 4toav of 6t avtopfll*3«
1 for*isie Mdieal •xaaioatioaf, Japca
1 B«l*r« •••• ••• *ff.4 T'« 7*>al«s^
1 Ma* ao« 37.4 Tc.
1
1 met nsiins; inomss: JIP*I:
l tiosiuii; itsmc; cumm: coBiii:
f cnan»i cofw: iio*t mcntT;
t XlrXOfl* R1€VX5HB; fltVGftllSB;
i itznivit aniion; scinin;
l sitnrvnu tmitmt nnoias; UK:
1 eciBj tion»: iivn: EIBIITS:
1 cmnn: cnmittii: ism: insais:
I 91BC1H5? SflBHS L^VSS; AOtTft;
I BETU.S; coiriiinn trttniion; an:
I focnstc atcKiis
i
i
a) O.oa » or - 0.0* 1 i| Ulas
19/9 ("t *t) | t) r*ail<*
11 0.1* * or - 0.09 |
19/4 (**t »tj I Itol i qto«> of *1 aitopsl**.
t focmclc aedical •xaBlaatioM* Japaa.
j ••l*a« ••!> «9» *9. < rr. r«ail«*«
t i«*» «»• 37. < rr.
1
1 i»ci tLBBtin: inorsiss; J»Mi;
l itenioi; unite: cisiioi; COJILT;
cncBim; cctnts i>oi; MKOIT:
Mnoi: iinisiiii: uie»tsi;
tOBTDHB: IITTMIT; SCMDIDIi
SI1HI015 TIUHII9: TtlUIOl: tIKl
citmani ctinuiM; EEIBI: BOSCIKJ;
titoifis: silBCi; I.HK3: loiti;
RItUS: CO1PIB1IIIE IflLVltlCIS: SSI;
reimic neiciri
lErnno



Takaia, a.
Sicakl-lamaoto, B.
tauo, t.
Tarai, B.
1 999
Ircklra of
BiTirauatil Maltk
3S(1|l3«-«*













Yikana, B.
laaao, K.
Twal. I.
1980
IrchiT** of
e&ftroiMital Baallk
35{1):36-»»










                                                                                                                                                                                    CO
                                                                                                                                                                                    o
IIICT omrosRioi sitioai 01
I TISS1B
1
1
1
1 *5M
11094,
fllSll











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I
i
l














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I BEIHOB
t
1
1













I iDaia
I OF CASES

*) 10
b| 8
c) lot
9lT«l










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*) »ot given
b) lot 9lm
c) Vat 9tr«a











mi

il 16.3 » or - J.»
a9/Jl
b) 9. 1 » or - 1.8
W/il
0] 52.9 « « - ».7
««c« Ticttlf-ciloiie
ttlttttzltlo*, BO Tttuia 1 deficiency
t) S«T«r« fretalc-calorl*
talmtrUloi ui Titttin l aifidancy
cj IcaltbT eettiol*

l*l>o«ri«bed Thai chUiron, aq«<
1J-60 to. Controls. Tkal children.
•9«a 12-sa >c« jaM aodo«c»iK»>lc
t«ctqro«»d M Mlxwrlfkvd.
UlIllID; CBI1D1H: BIOOD PUSH;
•wsiTioiit Bincitian: IOTSITTOIH
B1S010MS: PEOTWS: TITIIII 1:
III IS MS
fBIZI»CI

siith, r.i.
Sasltlod, I.
tliuugtal. o.
tcltTHIE, C.
Gooi**x, t.S.
dlsnf s.r.
1975
iMticai Jottrml of
Cllileal lutrltioa •
iBj732-T3i




                                                                                 (ISIt FtGZ)
-------
ritatio J
tt!03-57-«
ntcr coMosmoi »nora en nvemmtn
                                                                                (COITIIITEBJ
nssni -
aS55
Blood.
aorBB












stposvn mm















iiuRicai
BETBOB















tnsa,
01 C15BS















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*) lot ji»aa
b) lot giT«a
c) lot glv«B
d) lot giMB











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a) 28.5 » or - I.I
a«/dl
b) 27. « « or - l.»
«9/dl
e) 2».7 » or - 2.2
no/Si
d| 36.7 * at - 1.6
«g/dl
(S.E.)






GS1I111 XirOtllTIOf
a) 102 Bigrait ekillni
b) 5» boys fnw »>
c) 43 girl* team a)
J) coatrola froa ottoc «tidi«s
35.3* of •) k«d <20 ««/U

}-n «o olds, bclo« 3rd pozeoatilo IB
bt, lit, *«d k«scj drci>f«r«BC«,
cbildcoB of BexicaB-lBoricu far*
•OTkors. Controls, yona.
tlldl«-cla*« ekiUcoi, Colorado.
TITUII 1; CBI1DHI: IRC; UIB;
HOOD niSHl: BMOB SIKH!
ccttnkmi ttitmiois: met
it inns; COIOHDO
nmncE
Cbu*. B.«.
RaBbidgai, I.B.
Baractt, S.B.
Boats- Jacobs. B.J.
Leu, K.
elllospl*. J.
1980
lB«ricaa Jootaal of
CliBlcal Batzitioa
33:23*«-23»»





tine
TI«0-66-«
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lt« C5.38, HP «1«.S C. BP «•« C, TP 1 n Bg at ««T c. 10 BB Eg at  S40
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a| Berkot
t) CoattolB

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MS ») 1 la) lot gin* 4 a) 27.1 ag/g wt rt | *) *or**r 1 Byodo, K.
b> 5 | b) 11.9-2C.t *g/g >*t *t I b) lot glrea 1 b) Cntral* 1 Saiaki. S.
Ill 1 r»roT«. 1.
1 1 | Jain*** ior««r, tS rr old, at 1 Bcskizaia, K.
II | client* FtodociBO Blast tor 30 yr. 1 1980
1 | | Diad at aaxillary and Inm caac«r. | Xatvrutioul archives
1 1 | Controls, 54-71 yr ell. 1 of Oceapatio*tl and
III 1 ziTlKMueital Malta
1 1 1 91(11; 1BXPO3I TISSOB; 1O1T1; SOBJ I «:t«t-I50
I i < aisioB: iBiii: cisun-Lna: CHEWOH; i
I i i xiajZTs; HTM: WBSS8 ECSCLXS: I
l i i HBCBHS: SKI; cBtonvi: carpet; i
1 1 1 BIT US: II»C; IIBDStBIll tiirfS; |
1 I I muiTiai: cccvMTiam suiiDS: i
1 i i ECPOUTIOI inosnc i
i i i i
III l
US 150 r *) lot oirw | a) 18.7 * or - 6.1 I a) ZrytkrocytM. U I-« ao oM» 1 list I, T.
1 I)} lot iriMa | ug/g Hb | t) Irytkioeytu. 1C T-12 10 ali* I 1980
1 e) tot glrea \ b) 27.6 t ot - 3.6 | c) ot jlT«n | ag/g Bb | 4) Erytkraeytea, 21 I1-t5 yr o!3» I Bedical Sciences
1 | I •) >ot glrra 1 c) 37.* * or - «.« 1 •) Irytkrocytu, 52 ad:7-13
f 1 It) »ot J!T« | ug/g Ib I () utakaeytM, « «-10 yr all* I
1 f f 9) *<* gi»« 1 4) *2.3 * or - «.2 | q) uakacytt*. 1* alolts 1
1 1 1 «g/9 Hb | |
J 1 •) «2.2 * or - 5.6 | (taltky »abl«ct». 1
J | ag/g Ib I 1
J 1 C) 0.093 * or - 0.022 I HIC; lOULTS; CBZLOan; J1F1I; 1
1 i noyio (B*7) c«iia i amis: BLOOD PUSBI.- isTTSjocrris; »
1 1 9) 0.129 * or - 0.03} | ItVKOCntS: 1SE |
1 1 ug/lO(E*7) nllc | 1
....... i 1 i
1 1
«S a) 13 •) »ot 9lT«« a) 79.5 « or - 13.6 | a) 1-« ma old I Ushl, I.
M 21 b) »ot gt»«« n 21 c) av»t glT.a bl »*.» * or - 17-» I ej IT-IS yr eld 1 Biroshlaa Jotrnal of
f d) 52 «) lot gt»« «q/dl | d) Walt* | Rcdleal Sciences
1 01 101.0 » or - 22.6 | | 29(1):7-13
1 ng/dl | Malthy aablccta I
1 J d) 9S.9 * or - 18.6 I I
1 1 na/dl | TIIC; 1BOII5; CfilLDSIJ; J1P1»; |
i i mils s sioo c ntstn anttocmst i
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» i « i
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1 b) 60
1
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1 1
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1 b) (0.8-1M.1 ia/100 al | no/100 •! | t) F«iJ«nts at follatfl area t Roela, B.
1 b) 77.2 * or - 2.1 | | Bernard, t.
1 04/100 al | lain, uai aoc *2.3 yr, froi I B«ck*t, J.P.
f (S.S.J | C 9* »iomt children 1 Clias*, B.P.
b) lot gtT*i 1 ag/dl | t) 53 boys fro* a] I Baabia^e, K.I.
e) lot glT«* | b| 7«.3 » or - 1.6 t c) *1 girls fro* a) I B»cn«tt, S.I.
i) lot gtnn I ag/'Jl 1 4) control* fro* other atallcs | Hoots-Jacobs, B.J.
( c) 7t.« •> or - 1.5 | fypozlacMia (<6« a
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1 260























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1
1
76.* tig/too al I t) lesiaeats of Lleaa (But pollute!
85.7 si/100 •! | area)
89.9 nf/100 •! I t) leaideat* of Bn«Mls (!•*•
onetcic I fcllvtal ar«»)
1 c) Msltoat* of Chaclsroi (control
1 it««)
1 Korean* vitfc aa acctmlatlog of C60 ir old.
I t«ta««t« of the >aM areaa 35 rr.
I l«lfi«i
I
I Birsiaa: mows; \st; BLOOD tnsai;
I mis; c»ama: mo; BMC DEI:
1 Bfins; «ic; ttDvsniti mssiois:
1 iiDusrniii jcttntioij POPOLIIIOI
1 11SOSOSB; DBB» 1BEIS
1

1 Baric*, irofil* of healthy nblects.
1 Bastllm data fox tetenlalng ehaages
1 li Bitritional itatu fro* indastclal
1 {cod pneesitgg t*ctniqn*s.
1
I in XEU»D; u>m,TSi tens; xifurs;
I HOOD ssunu: smij KIDKTS: UTIB;
t Bill: ISTltl; DIRS; TOODSi SOILS;
1 TietitTiai; CURIOE; COPPIS-,
1 Biieinst: imis: TSICB Eirastts:
1 K1C
i
t
&) 1.44 * or - O.OS | a) Itanaai Citr. KS, karl-««t«r axea
aq/1 | t) Mans CltT. BO. ioft-»at«r area
b| 4.28 * or - 0.82 | slwlflcantlj loner lenl cr<0.01) 1m
aq/lg 1 kat4-«ater area.
t
1 KS and no reildeata aatched foe a?e
1 (ceaa aaes 37 and 37.7 rr), MX,
I Icaotn of resldeaoe, aarital aad
1 ccoooalc itates, occvpation, mtber
1 cf cklldrea. saoklaq habits, at. vt.
1
1 ta hacd-natec acea. «l«j«l£icwt
1 iicrease in brpeiteBtloa. ICC
1 akaor>alltl«t« aad bTPcroriceiia.
1
I tllStS; B1SSCOBI: aDOttS;
1 omnoTiscnm DISUSES:
1 Biintnsioi; BLOOD SHOB:
t ccBMimvs mioiTiots: CIOIIOR:
1 cucio!: CEBCBIVI: LITEIVB;
1 HGIISnB; tSOSFHOSODS; rOUSSIIR;
1 50DIDB; II1C; BfOtCcmOLaTIOl;
I cmncns v«Et

1
a) 113 » or - SO I >) lea, lo» tlood prea*ace
»j blood fresanre
og/»l I taafc tcoa vmloes atojj. a«tlaat«d
1 dallr dietary Intake 4.5 a?.
1
t Polynesian icsidenta of Vokelan
1 Iflands, crovded condltloaa.
1 (nceiateiee eooaoar- lea, *eaa a«e
1 45 jt, aeaa fct 1C7 ea, aeaa « 74 k«
1 (oaea, a«ao a«e «* rr. aeaa bt 165
1 ca, aeaa vt 79 kg..
1
1 COPPEB; Zinc; BIOOD SSBOHi BUB;
I «IILS: mint
- - . t
(BEIT P»SB) ....,.,.
HfEEEICE


0»ls, B.I.
anerys, B.B.
ncaet. J-P
Bernard. 1.
«ei
EmTlcoBaeat&l Beaeaceli
24:117-130












Gotbcie. S.B.
Coblnsoa, B.T.
1178
leu Zealand ledical
Joacaal $7 (603): 3-8








llereabaaa, a. L.
Tlelscaaaa, I.I
Dmn, 3.
Inoli, J.
1975
lancet
1(HU): 1008-1016


















RcKemie, J.B.
GBtkCl*. I. I.
Prior, I.a.B.
1978
iaericaa Joernal of
Clialeal latrltioa
31:422-42)












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                                                                                                                                                                                          v£>
-------
time
atw «$,}•. tt »19.5 c. BP »0*  C.  TP 1 n Bg at MT C.  10 n  B< at  5?0
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t
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ISCT
90M
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US
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t
ili
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or cisss
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i
luei i mi* i ezirui nrosuTitw i nrimci
1 1 1
II I
a) lot glT« | *) 10.« «g/o w»t rt f •) *ork«r I By»do. K.
b) 1.9-12.5 nj/» nt «t 1 b| lot gi»«« | t) coitcol* 1 Saioki, 3.
1 1 1 tmcmjt, I.
1 1 Japa»*M worker, 65 yr old* at 1 Bcshlzate* K.
1 1 ciroiat* crad«cl»9 »la«t fat 30 ir. 1 1*«0
1 1 Bled of aailUarr a»d la* caacer. | Zctenatloaal archive*
1 | cettrol*, 59-7i ft oia. 1 of Occip«tiOMl tnl
1 1 1 «BTitO»»«»t«l HMlth
1 1 JJtM; HIIPOS1 TI3SUI; lOXTt; SOfB I «:!«!- ISO
f | nlCO*; (1111} CREIKIM; CMEI808; |
1 1 IIDUtS: 1ITSB; MISS; BOSCtIS; I
1 i tncsm; sue cKonoi; CCCPEH i
1 t tiriii: tile: inosTim. PURS: i
1 1 IlllUTICt; COCITPtTIOlU, BltllKS: 1
1 i tcFiunoi txrosns i
i < i
1 I l
•) 8.4-1T tg/g (Mt «t) |i) 11 » or - 3.0 ng/g 1 •) Balm. c«»bt«a, t mbjcets 1 Tifca», a.
b) T,*-9.2 »V9 (o*t «t) 1 (»«t «tl 1 t) r«iali«. content, 3 «b}«ct« I sazaU-TMUoto, s.
c) 9.7-17 tq/f (nt it) | b) ». « « or - 0.9 I c) B«l«, c«r«bell«», C mbl«cti 1 liuo, 1.
9) 7.8-22 wi/g (mt it] | 19/9 (mt irtl 1 d) M»l«i. CKclMllm. • <*b-j«cti 1 T«»l< R.
1 c) 13 « or - 2.S og/tutloi>« Japac. I Eavlroncmtal B«alth
1 (*«t "t( | lalva. ma« »ij« •». 6 rr. F.MlM, I 35(1>:J«-»«
1 j i*a> aa« 37. t fc. |
1 1 1
1 i Tucr nsiEiis; tirotsissi JIPII; i
1 i naarna: nsaics CIBBIOB; COBUT; i
1 i ciicBiui: CCPP!§: HOI: iMcmt: i
l i nrioB: Bieftsni: a««s»«tsz; i
1 i i»»ioii7«.- i»ii»o»r,- scjnign; i
l i auBiius: iiunn; UUDIHIS UK: i
1 1 S01D; BIOBIBI: LITE1: KIDtnS: 1
I i ctKssm; criiBiiiffa: RIII; IBSCIJS; i
1 | EtICBIU; SPIKI; tOWJS; 1OBIH: I
1 1 BIHISi COBMSITITI STIWITICBS: SIX; |
1 1 FCItrSXC BtOICIBB (
II 1
a) dot glm I a) It.* ag/g | a| tor tec - nnbcoa (occipital) f Syoio. (.
b| 11.0-12.* aj/« | 1| lot »ir«» | I) S caitroli - cerebral (frontal) I Small, S.
c) lot aiT*» | e) 13.5 aj/f I e) lorker - cerebellM 1 Foray*, I.
d) lot giT*B I i) U.O ag/g | d) 1 coatrol - c«c«b«llaa I Mialzaka, K.
1 r«t «t ( | 1910
t 1 Jipan««« «ork«r, 65 rr old, at 1 latenttloatl trchlTM
1 1 cbroaat* trodaclat pltat for 30 rr. 1 of occupational and
( 1 tl«d of nzlHarr *ni luv cucor. > CaTlroueatal Hvaltk
1 I cc.tcola, 5»-7» jr old. t M: Id-ISO
1 1 1
1 1 JIP1B; ID IPO SB TISSOZi 1OST1; BOO 1
t 1 eUBOl; BBlIi; cnCBEUIIHi CmEEtVI: 1
I i KIIIETS: lira: HISS: aasciis: i
1 i dictns: sun; cnonoi; caifti; I
1 1 »R1U: tltC; IMOSnlU. PtIBtS: 1
1 I 1I»»UTIO»; COCVPITIOIIL BIH1BS; I
l i termiTioB EIPOSOBE i
i i i
1 1 1
ot gi»« | «.» ng |(1 s«ipl«d at rat* of 1 1/aia, 2-10 f UselBson. E.e.
1 1 all aft«c baral«« * arc »«lalag rods. I 9«n*del««r, 6.5.
1 1 1 Johausog, T.B.
1 1 Oal»erattj phfiics shop, Florida I Vlocbeater, J. «.
1 1 1 H7t
1 1 FIOHDU UBITS; BRUTE; CaLCIOH; I linal* of Occupatlonsl
1 1 ctLOBiit; CBXORIDB; copisi: uoi; I iTgleac 19:225-238
I I mo: alienist; ncicst: MTISSIUB: i
1 1 SOIFOJ: TXT1IIVR: TM1JIDS: XI1C; aXC 1
1 1 polnnioi; mats: iiraasTBiii. \
i \ IYBOSMBICS; nkct xurans i
i i i
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or cms
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a) lot fiMD
b) lot «lT«B
CJ lot 9i»«l
A) lot »lw«
mi i cEiziiL iiroiBaTioi
t
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) 1»0 ppa | t) contrail
1
1 Iticnlnf dlsiblad »id >oc»l 3rl and
1

1« «o «U, on aiml»«ion b) l«2 «o/g | t> n 19 old. n aliiailog c) 13S «9/g I c> 10 M 014, r«cor*nd 4) 258 «9/9 | a> 11 10 old. c«oT«r«d 1 Ccppoe-a«(iel«it chlllni. • 1 C1S« ETST01IIS; CIILmili 1I3Z»XS; I tut: cofpti; anus: me «l«l* USE) ' ' - KBTEKEICE rial, X.O. PatkM, I. 1WI Sclaace 198I»313):JO»-206 Ctlttlvborowih. 6. 1980 Seine* of the Total f»lro«M«t U: 53-75 Chlttl«l»rot>9b, a. StMl. B.J. 1980 Sclottco of th« total tDTlroBKOt 15:25-35 BcaatloU. S.E. Cotluo, 1. B*«ttl, 1. Graba», S.G. 1*80 La»Mt 2(»190) :l«3-ail LO

-------
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7100-66-6
n
t« 65.38, HP 419.5 C, BP 908 C, vp i aa Bg at 487 c, 10 aa Bg at 590
(CORTIROED)
TISSUE
4575
Balr

























4576
Ralr












4577
Balr









4578
Ralr







BTPOSOBB BODTB









































Inojestion



















lUlTTICU
HETBOD
HI


























HI
























IIS







	
HOSBSB
OF CISBS
a) 16
b) 22
c) 13
d) 11
el 15
f) 22
g) 10
h) 18
i) 13
1) 3
kl 7
1) 12


.












a) 23
b) 19
O 42

e) 26
O 40



















a) 17
b) 17
O 30
d) 30





BIRGB
a) Hot given
b) Hot given
c) Hot given
d) Hot given
e) Hot given
f) Hot given
2) Hot given
) Hot given
i) Hot given
fl Hot given
k) Rot given
1) Rot given















a) 108-190 og/g
b) 120-357 ug/g
c) 108-357 ag/g
d) 103-194 ag/g
e) 139-318 ag/g
f) 103-318 ag/g



















a) Hot given
b) Hot givei
c] Hot given
d) Hot given





BEIB
a) 218 or - 9 ag/g
b) 225 or - 9 ag/g
e) 200 or - 32 ag/g
d) 225 or - 16 ag/g
e) 232 or - 22 ag/g
f) 225 »r - 296
ag/g
gl 105 or - 37 ag/g
h) 245 or - 52 ag/g
i) 140 or - 49 ag/g
1) 260 or - 87 ag/g
k) 180 or - 41 ag/g
11 175 or - 118
ag/g













a) 150 ag/g
b) 167 ag/g
d 161 ag/g
4) 145 ag/g
e) 168 ag/g
ft 166 ag/g
ledians


















a) 216.2 « or - 43.2
ag/g
b) 239.7 * or - 108.5
ag/g
O 181.6 » or - 31.4
ug/g
d) 235.2 » or - 47.2
nqSa
Mysy

G8IIB.U I1?OBHATIOB
a) Controls, at birth, aales
b) Controls, -at birth, females
c) Fall-ten low birthvelght, at
tilth, aales
d) Fall-ten low blrthveight, at
tirth, feiales
«| Pre-tern, at birth, nales
f) Pro-term, at birth, females
g) Controls. 3 BO, Bales
h) Controls, 3 BO, females
i) Fall-tern low birthvelght, 3 aa.
tales
1) Fall-ten low birthveight, 3 ao.
females
k) Pre-term, 3 ao. Bales
1) Pre-term, 3 ao,. females
lUdians » or - SB
Reonates in Balifax. Pro-ten group
mean birthvelght I860 g, 26-36 »k
gestation, fall-term low birthveight
group mean birth weight 2371 g, 38-42
«» gestation, and full-tern controls
mean birthveight 3590 g, 38-42 vk
gestation.
aaiB; amis; ZIBC: COE;EB;
BIRGME3B; VMaDIDB; IODISE; IHPaHTS;
SIX
0) Rale controls
t) Peaale controls
c) 111 centrals
d) Dale tnltiple sclerosis patients
e) Teaale multiple sclerosis patients
<> 111 an It 1 fie sclerosis patients
Samples from 7 scalp sites in each
sab ject
CHID*; igaits: CKBTHIL HEBVODS
STSTEB DISUSES; HUB; alOHHTOB;
BBonuB; catena; CHLOBIBB; COPPEB:
8CID; IODISE; BIBOaRZSB; RBTalS;
SHE", Til: SI17EB; SODIOS; S01FOS;
VI»»DHJB: lire
levle*. Profile of healthy subjects.
Baseline data foe determining changes
in nutritional status from industrial
(aod processing techniques.

RIB tBIlIRO; IDOLTS; FBTOS; IR*1BTS;
BIOOD SEB0I: HUB; KIDIBTS: IITBB:
RIIK; BSVIEl; DIRS; FOODS; SOIIS;
?tORITIOR: CtDBIDBl; COPPBB;
BIHGaBBSB; RR11S; TBICB E1EBEBTS;
me
01 Bothers of infants with scina
tiflda
t) Infanta vith spina bit Ida
c) Control aethers
d) Control infants

Hevborn with cystic spina bifida. and
Bill): ZIRC; IHFIBTS; PBBGHIHCT: TBICE
IIESBBTS: GEBHIHT
BBFBBBBCE
Gibson, B.S.
Dewolfe, B.S.
1980
Bntrition Beports
International
21(3):341-349





















fiyan, D.B.
Bolzbecher, 3.
Stoart. D.C.
1978
Clinical Cheaistrv
24(11) : 1996-2000








Gathrie, B.B.
Boblnson, R.F.
1978
Rev Zealand aedical
Journal 87 (603): 3-8






Bergnann. I.E.
Hakoseh, G.
Te«s, S.-H.
1980
laerican Journal of
clinical Bntrition
33:2145-2.150

-------
 Zioc
 mg-66-f
tm
»*» 65.38.
           •P  «19.S C,  »P  908 C. W  1  mm  Rg at *87 c. 10 mm Bg at 590
                                                                                      (COIIIHED)
1 TISSUE
t

1
t »S79
1 >alr
1
t
1
\
\
1
1
1
i
•
1
1 »5BO
1 Hair
1
1
1
1
1
1
1
1
1
1
1
t
I
1 4581
1 Bair
1
1
1
1
1
1
1
1
1
1
1
t
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t
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1
1 as 82
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IMlTTICll 1 IOBBES
BEIBOB 1 OP CISBS
fl
1
$ 1 a) 11
1 b| 13
1 c) 17
1 n 28
1 el 14
1 O 1*
1

1
1
1
1
1

1 a) 96
1 b) 12
1
1

I

1
1
1
1
1
I

I
US | *1 IS
t **) 1^
1 cl 19
1 *) 15
1
1
|
|
1
1
1
|
1
1
1
1
1
|
|
•1 I a) 10
1 b| «
|
i
i
i
i
i
i
i
i
i
i
i
i
i
i
i
i
i

I BIBSB
1
1
1
1 a) «ot given
I b) *ot given
1 c) mot givem
1 d) lot givem
1 e) mot given
1 f) mot given
1
1
1
1
1

t ,
\
1 a) lot given
1 b) lot given
1
1

1
1
1

1
1
1
1

i
1 a) Bot given
1 hi lot given
1 cl lot given
1 dl lot given
1
1
1
|
|
1

|
|
|
1

|
|
|
1 «1 7.0-43 og/g
1 b) 4.9-25 ag/g
1
1
1
1
1
1
1
1
1
1
1
1
t
1
|
1
1
1

1 SE»I
1
1
1
1 a) 138. « * or -
I ag/g
1 W 159.1 » or -
) ag/g
1 c] 108.2 t or
1 ag/g
1 4) 164.8 » or -
I »g/g
1 e| 106.1 * or -
1 t| 121.7 + or -
1 ng/g
1
I
1 at 94.1 » or -
1 ag/g
1 b) 130.7 * or •
1 «g/g
1
1
1

1
1
1
1
1
1
i
1
1 a) 259 » or -
i »g/g
1 b| 241 » or -
|c| 163 * or -
1 d) 144 » or -
1
1
1
1
1
1
t
1
1
1
1
1
i
1
(*«t »t) I a) 24 « or -
(vet »t| | <««t vt)
1 b) 17 « or -
1 (vet wt)
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
(BHT PISE)
1 EiituL intniaTioi
1
i
l
64.1 1 a) 6-11 mo old boys
1 b) 6-11 mo old girls
98.7 Id 12-23 mo old boys
1 6) 12-23 mo old girls
- 47. 0 t e) 24-35 mo eld boys
1 t) 24-35 mo old girls
13.0 |
1 lav Income ccsta Bicaa 6 eto-4 yc oils
47.7 |
| IIBC; COST! Elca; CBILtSEl: KPUTS;
50.7 I iraiL UBaS; B»IB: SEX; TfilCE
| EIRBEITS
1

5.3 | a) aigramt children
I t| Controls Iron otter stmdiea
• 8.3 | a) and b) differed n<0.001
1
1 2-69 BO olds, belo* 3rd percentlle In
1 ht. 
                                                                                                                                                                                            U)

-------
tine
It
Its 65.38. «* »1».5 C, Bp 408 C, VP 1 am Rg at 187 C,  10 aa Sg  at  5*0
1ISSDE
'
4583
manev














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0585
Kidney














EIPOSOBE tOOTl
'

















































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BETHOD
US














Bl
















. .
113















BORBBB
OF C1SE3















a| 21
b) 3
















a) 1
b) 5














suet
..
a) not given
b) Vat given
c) 1759-3278 ppn
i) 1682-7000 ppn
lah vt

'








a) «.1-»6 og/g (vet vt)
b) ».«-«« ag/j (vet «t|
















a) Sot given
b) 31.1-66.6 ag/g vet vt












-
(BEIT
ItElB

a) 3653 pp«
b) 3920 ppn
ol 25 11 ppn
« 3551 ppa
ish vt










a) 39 » or - 29 ug/g
(vet vtj
b) 33 • or - 20 ug/g
(vet vt)














al 3*. 8 ng/g vet vt
b) lot given













f»GE)
GfltUl IVFOGI1TIOI

a) 17 cancer patients
t) 58 non-cancer patients
c) 10 non-stokers (never saofced)
i) S snokere, 1.5 packs/day

««topal«s free hospitals It Sorth and
South Carolina. Blacks and
Caucasians, (dulls, ages 16-91 yr.
Children, ages 4 4ays-6 vr.
SITUS; BOHtS; 1ITSB; KIDBSTS;
RtVtlS; CHTIDEES: CJDSIOB; ?I»C;
l»0; SOBTH CJS01IM: SOOTB CJBOTIS1;
intopsiES; Gioiccmotinoi; BICUL
STUD IBS; «5B; SHOICUO: tOBSCCOS: SEI;
>fQ PltS IS
a) (tales
t) resales

Fros a 4roap of tl a at apsis s.
forensic redlcal exaiinations, Japan.
Bales. M» age 40. t Tt. Females ,
•ean a
-------
ZlBC
7MO-66-6
tn
ItB 65.38, HP (19.5 C, BP 908 C. TP 1 •• Sg at  «87 c.
                                                       10  •• Rg *t 5*0
                                                                                      (COBTIBIED)
1ISSBE
«586
Mdnay
a5«7
Kidney
•588
Liver
»589
linr
ztosoBB BOOTE

•gestion


IBUnlClI. |
BETHOD
S

US
Bl
BDSBEB
F C1SES
8
9
12


a) 8
b) 7
MICE
1S-»7 «g/g
19-55 ug/g
17-* 2 »g/g
t «t

a) lot given
b) lot given
c) 3220-12850 ppn
d) 720-5800 pp»
lab «t
a) 37-180 ug/g (net >t)
b) 17-91 «g/g (vet ¥t)
•Ell | 6BMB11 IBPOBfllTIOB | BFEBEBCB
| 1
t 1
25 ag/g 1 a) Controls 1 Bruno, D.
32.5 ug/g 1 t) "orter group I | Bordberg, G.
25.0 ug/g I c) locker grew II 1 Bester. P.O.
et «t I 1 1980
edians I leeeased refinery »»d sselter I Science of the Total
I letters, aqea 55-76 yr. exposed to 1 Kmrlronnent 16:13-35
1 i«»»y ratals 1-3 decades. Use 1
| tstMea retirenent and death 0-1.5 yr I
1 it qro«p I aid 2-19 rr. gcoop II. 1
I Controls, agts «3-72 jt. wko lived 50 1
j III troa the factor?. S»«d«n. I
1 I
I SIEON: ciDitns; KNITS: LITEB: I
| IBBGS; COIPlBlTItB ET11BHIOIS; I
| IBOOSTlIU BTCIBBB: BBlSIIlSBBBt 1
| IRBODS: 1RIIOIT: 1BSEBIC; 1
1 muraim; CIOBIVB; cismH; CBBOHIOR; t
1 cceiit; coppn; SOLD: IBOB; i
| IIITBIIOB; 1119; aiBGlBBSI; BEBOJBT; I
1 BQITBDBBOB: IBOSPH01DS; BDBIBIOB; |
I sciBEioa; SIICTIOS; SIITIB: 111; i
1 T01GSTM: tIBC: BI11TI H121SOS: I
| IBDBST1I11 PtlBTS: SSEITIBS 1
| •
| twriev. Profile of healthy subjects. I Gnthrle, B.S.
1 Baseliae data for detersinlig changes 1 lobinson, B.F.
I la ntrltioial status troa Industrial I 1971
j teat poisoaing techniques. I Be* Zealand Hedical
| < Journal 87 (603) -.3-8
| BIB ZE1L1BO: IDOLTS; 'ETtJS; IBF1BTS; I
1 BIOOD SSBOB: Bin: HIBIITS; IITSI; i
| BHK: SBTIIB: DIETS: FOODS: SOUS; I
1 tisn»iio»: cuBina; coppii; i
| B1B61BBSI; BR1I.S; TMCE ElEBEBTS; I
I ZI«C 1
| 1
I 1
a) 5063 ppa | a) 17 cancer patients 1 Hanser, D.I.
b) *120 (pn I b) 58 nan-cancer patients 1 Caloeci. l.T.
c> 6068 ppa I c) Two 10-19 yr olds I Basselblad, T.
d) 3297 ppn I 4) Three 30-39 jt olds I Vllllaas. B.I.
ish «t | 1 Piakerson, C.
| latopstes free hospitals In Borth and | 1973
1 South Carolina. Blacks and j Journal of Occnpatiosal
I Caucasians. Idults. ages 16-91 yc. 1 Bedicine IS (12): 956-963
I Children, ages * daya-6 yr. 1
1 1
| ClTltS; BOBSS; LITEB; KIDBITS; 1
| IIOITS; CBItCBBB: ClDHOBi 2IIC; |
| HID; BOMB CUOIIB1; SOBTB C1BCLIB1; I
| ItrtOKtES: BI01CCHB011TIOB; S1CIU. 1
| SIOEIES; 1GB; SBOKXBG; TOB1CCOS; SEX; 1
| HOPllSIS |
1 	 - I.,
I 1
a) 97 » or - 59 og/g I a) Bales < Tulcana, fl.
(let «t) I t) Fenales 1 Suxnki-Iasnnoto. fl.
b) 50 » or - 20 ug/g | 1 Inano. K.
(«et »t) | fret a group of 61 autopsies. 1 Teral. B.
1 forensic sedieal ezaslaatioai. Japan. 1 1980
| Bales, aeaa age aO. 6 yr. Peaales. I IrchiTes of
j scan age 37. a yr. t Ea*lroneental Health
t | 3S(l):36-«a
| ItlCI SLI8I11S; lOTOPSIKS: J1PIB; (
1 noaiBn-i; itsEBic: CIDBIHB: COBIIT; I
1 CBBOBina: CCEP^B: IWB: BtBCORr: |
| IIDHl; RICBISIOB: B1BG1BZSE; 1
1 BOBIDIUI; 1BIIBOBT; SC1BOIVB; I
1 StlEBIIB; TIIIBIOH: flBlDIVB: tIBC: I
| GOLD: BBOBIEE; UTEB: KIDBIIS: I
i ciimoB; csBEBEiinn: BEIBI; BUSCLES; i
i iiiciEts: sptEEB; mas: IOBTI; I
| BITltS: COilPlUTITB 1T11O1TIOBS; SEI; (
| ICtllSIC BZIICIBB |
1 1
                                                                                                                                                                                            u>
                                                                                         (BZIT
-------
tl«e
i«ao-«6-6
t«
It* CS.3*. BP »19.S C, BP 908 C, n 1 n «9  at 487  C.  10  n 89 at S90
                                                                                      (COBtlEBID)
1
t
1
1
1I3SDI
as»o
liver
«S91
HTer
1 »s»2
lint
1
t
•5*3
Llm<|

1
1
1
r
inosm Boats


leoeatioo
1
1
1


mimcu
BBTBOD
us
us
1 i
i
i
n
B9BBH
or c»s
«) 1
b) 5
•) 8
M »
c) It

•1 3
W 2
B1BSE
*) lot 9lT«»
b) (2.0-107 og/9 mt •
a) 30-99 a«yg
b) 22-103 «a/»
0) 19-15* ««/9
Wt «t

t) ».3-12 B9/9 («et »t)
b) 10-t6 eg/o (vet >t)
m« i "eiaiiu nrosBuioB I EsreBEBcs
i :
i i
at 123 «9/» Mt «t | •) torter 1 Brodo, E.
b) lot firm 1 t) Coatrola 1 SateU, 5.
I I furor* . *.
1 Jaraaese iiocler, 65 TT alt. it 1 Reaklzaka. E.
1 cbronte rrodaclao. plait for 34 rr. I 19(0
| ti«4 of uxillacr u< luv cue«r. 1 tit«r*«tioul lrchiT«
| ceittol*. S9-7C rr ol4. f of Oce«pttioiial *ti
1 | EnlroiMittl B««lth
1 J1FH: IDIPOSB Tijsnt: IOITI: ton I <6:i«i-iso
1 8IEIOI: BBUI: CIUBXUOI; CEBEEEffE; 1
1 VIDIEYS; LITEB: VIKSl RVSCIZS; f
I HICBE13: SKII: CEBOUIM; COPPBI: |
| «!IU3: tlKs IIDBSTSIIL PltRS; (
I IIB1UTIOI; CCCDPITIOIU. B1Z1BBS; |
1 ECrntTIOB tlfOSOB! |
1 1
1 1
a) (1.0 tj/9 1 a) Ceatrol* I Vrna, D.
b> *?.o 09/9 I t) Voclnc qroap I I «or4b*r?;. C.
c) 66.5 ag/9 1 «) «ort«c qraap it 1 »e»t»r, P.O.
let «t 1 1 1»80
Icdiau 1 t«Ms«4 c*f inerr asi «a«ltar I Sclme* of the Total
1 tartars, a9«« 5S-7S rr, axpaovd to 1 Bnriroamit 16:13-35
1 k«a*r a«tali 1-3 4« limd $0 f
1 k* fcoi tke faetorr. S»«a«n. 1
1 1
1 sitcM: ciDitEis; rnmrs; IITEB; i
1 miss: cogeuain irnajriois.- i
I UEOSTRIil KtSXZIZ: 8U5VEiaZIT |
| IRBOOS: tBTIIOBT: IRSSHC; |
1 TitLinm; ciEmioi; cisitra; cHsoaion,- i
1 ccriti: coppu: eoic: itots I
I Liimmrs: tun: DIISJIESB; BESCOBT; i
I BCLrBOESUd; fBOSPBOBBS: DOBIEIUS; I
1 sciBDini; stunos: 511 TIB; m; 1
I m«5STB»; UK: Stiffs SlZlSfS; |
| IIOOSTtllt Pt»»TS: SR1TISS 1
1 1
i 1
1 f«»l«». Profile of k«alttr «biects. I Gatfcrla, B.I.
I fascllM data for J«t«riinlBo ekame* 1 Robinson, n.r.
r la aatrltloaal «t»to» froi imlattrial I 1978
I feed pol«oata« t«chni7o«». I >•> Zaalaid aedical
| | Joaraal 87(603) :3-8
| Mt ZEU1EC: iOOlTS: MTDS; IVrlBTS; |
| tlOOB SStttHS Hill; IIOKIS; IITIS; |
I iltlt; ttriTS; BIBTS: ?OOSS; SOUS; 1
I fterritioB; CJDBWS: COPPU: i
I BIIClIESt; inal5; IB1CE IIZBEITS; 1
1 tllC 1
1 t ,
1 1
8.5 » or - 3.8 fa) f!al«s 1 lokava, B.
g (vet «t) 1 t) *eaal«E 1 Sanki-Taaaaoto, a.
13 < oc - 1.2 ig/g 1 t laaoo, E.
t «t) 1 rroa a group of 61 agtopslas, I Terai. B.
1 fervaslc aedical exailaatloi*, Japan. 1 1980
1 Bales, «eaa aoe »o. 6 rr. Feiules, t irckivea of
1 ie» »
-------
Mac
74«0-««-6
»t« S5.3B, n »1».S C, Sf »0a C, n> 1 •• Hg It «87 C.  10  »  Sg  at  590
TISS03



»59»
laag



















595
Ivag





















•MS
lilk










tosnt tons















































lagaatioa








intTTIOL
BsraoD


us




















us































1
1
I
IBim | B1KB
OF C15IS |
1
I
1 a) lot givea
1 b| 10.0-13.7 ag/g
1 e) lot glvea
1 d) 12.0-19.1 ag/g
1 a) lot given
1 « 7.5-1J.1 ag/g
1 »et vt
|
I
1
1
1
1
1
1
1
I
1
)
1
1
a) 8 la) «.»-2» og/4
b) 9 | b) 6.2-16 ag/g
cl 11 1C) a..?-* 15.3 ag/g
1 Wet vt
|
1
1
1
1
1
t
1
1
1
1
1
1
t
|
1
1
1
1
1
|
1
1
1
1
1
1
1
1
1
I
Kilt | 6BI1UL XIFOIBmOl
1
1

) 8.5 ag/g | a) lorkar, right apper lobe
lot given | 6) S eoatrola, right upper loba
13.3 ag/g | c) Vockac, right aidtle loba
i Hot given 1 d) 5 coat roll, right aiddl* lob*
) 12.8 ng/g | •) (orker, left lover loba
I lot given I f) 5 coatrols, left lover lobe
at vt |
I Japaaaaa varkec. 65 Tt old. at
1 chroiat* crodveiag plait for 30 yr.
I Clad of aaxillary aa& laag cancer.
1 ccatrols, 59-7* yr old.
1
| J»ll; aDIPOSS TISSUE; 1OET1; BOIE
| RIMO«; IB1II; crBEBEHOB; CIBIEBOB:
1 IIDRIS: lltM; IVIES; BISCLIS:
I f»Ct.
Snzaki, S.
»roy», 1.

1980
lateraatioaal archivaa
of Oceapational aad
tBTiroaaaBtal Bealtb
act 1*1-150












Brnne, 0.
aordberg. e.
Vaster, P.O.
1990
Sciaace of tba Total,
BaviroBMat 16:13-35

















Gnthrie, B.B.
Bobiaaoi, a.r.
197«
lev taalaid Radical
Journal 871603) :3-8







(HIT PISE)
-------
Mae
7MO-««-«
fa
ttf «S.3». n 4T9.S C.  B» 90* C, TF t M la at »»7 C. 10 aa So at 590
                                                                                     (commtD)























T1SSVI


»S97



Rascle

















»S»»
Bascle
t
1
1









4599
lail








1
f
f



MOO
Vail
1
1












1
I
















xxtosns sown

























1
1







1
i
1
1
1
1
1
1
1
1
I
9
1
'
t
1
1
1
1
Zaovstios


































IULTTIC11
ratios

n


















us




1
1
1
1
1
t
f
I
1
It




1
1
1
1
»
I
1
1
1
1
us



































•rain
or USE

«» *
b> *

















1
1 «
1
1








1
1
- -*
(
1 nl 9
b) 11














b) 17 | I
c) 19 <
a is t












-
	 Hisi 	
!

•> 10-73 eg/a (vet «t(
b) 11-72 ag/g |*et at)













nil i GEMUL nroiimei i nmiici
l l
i i
S1 » or - 1» ' '
(»rt wt) | t) resales I Sn»ki*Tiraaoto, I.
b) »S » or - 25 ag/g 1 | tnano, I.
(rat *t) | froa a groap at 61 aatepdea, I Terai. I.
1 foreaaie neUeal exaniaattoaa, Japan, t 1980
1 Bales, aeaa age *O.S yr. resales, I IrckiTes of
1 aean a«s 37.« yr. I Environaantal lenltn
1 1 35(1)53*-"
l TMCE tanns; tnorsnst jun; i
1 HOBnOT; 1ISEIIC; ClOSIM: COBUT: |
t cncBTKB; comt: itoi; incnr: t
1 iinnB; msusioB; uieiiissj i
1 laiiBint; iniBorr: sciniii: (
l snnxm; Tntiira; nitBim: nic: i
1 COIB; Btoaif!: urn: noiiys: i
1 1 CIII»n«i CntBEUVI; »ltt; BBSO.es; j
l l EIICIIIS; sttxas wmss-. iciri; i
l l intis; coaritiTin zrutrtTiois; SET; i
1 TCIIISIC BIBICIIE |
	 . — . 	 1 1
lot given 66.0 ag/g »et »t 1 | |Todo, X.
1 1 Sasaki, S.
1 Japanese eorker, «S yr old. at 1 raraya, 1.
1 ckroaete srodaclnq pltat for 30 yr. 1 ResUzvka, I.
1 tie*, of aailllary aad lang cancer. 1 19S9
1 1 tateraatioaal Irchives
1 Jim: IBIFOSB Tissue: IOST*; tout 1 of OccaBatloaal and







a) lot given
b) lot given














lot given
>) lot giVM
•) lot given
) lot given













1 BUBO*: mill: cnn»lltr»: cmaoii 1 laTiranaeatal Baaltk
l iiDinsi urn; vnest iirscizs: i *»:i*i-iso
1 tiiciitst sm: CB10M0B: catitt; t
1 BIT US; IIBC: IIDOSTSIU »U«TS; |
| IHUtTtOI: OCCOmiMlt lltUBS; |
i tctmmo* Hposnir. i
	 i i
» 1M » or - 75 pps I a) (oaan | Jtanabrocki, s.l.
W 153 » or - 68 ppa | t) lea | Kantbrocfci. J.I.
3ry »» 1 I«rt tkoab | Greco. J.
1 llso rerievedt knmn levela 30 other 1 ICaplaa. t.
t eleaeats | oester, I.T.
f 1 Brar. S.s.
1 taalthy 20-60 yr olds | e«staf
-------
 time
7»»0-S6-«
It
Itf tt.39,  IP 419.5 C. BP 908 C, fP 1 M 89 at M7 C,  10 •• !« «t SM
                                                                                   tcomim)
fXSSBI
Patents
a«02
Pancreas
•603
Piervsx
Skin
foson tons




HUTTICIt
BTTBOO

IS
US
us
r ctsss
7
3
aj 1
) 5
a) 1
b) i
a) 1
M 5
JMCI
1»-«3 ng/g (Mt etj
32-*0 ag/g (vet »tj
1 Bot given
1 2t.1-*l.a tg/9 »et vt
a) lot gin*
B) 15. 7-22.7 »g/g vet vt
a) lot given
b) 5.1-7.9 sg/g Mt lit
Mil | 6SBISU IBIOIUTIOX I BETBinCI
1 1
1 1
29 » or - 9. S *g/g I a) Bales I Tvkava. a.
•et «t) | 1) resales | Saznki-TMasoto, S.
36 • or - a.o ng/j | l laaao, x.
(vet vt) | HOB a groan of <1 sntopsies. < Teral. 1.
1 forensic sedical exanlnatiani, Japan. 1 1980
t Isles, senn age »0. 6 yr- 'analog, | archives of
1 nean age 37. « yr. ( Zsvironsental Bealtli
1 1 35ID-.3S-M
1 TBICB nzBtns; iirroMiEs: Jipti; 1
1 iiiBnm: usnic: CIDBHTB; coBut: i
1 cncBxra; conzt: IBOB; HIBCDBI: i
l lining! aiGitsivs; aiieiBtsz; i
l PVBIBIDI: ixnaofT; actBDira; i
i snnina: tiuBiot; nnoitnj zixcs i
l con; BiOBiBZ: irrra; noxtTS; i
1 cmmm: CIXIBZIUIB: BUM; ansais; i
1 IIICBBISI SP1IKB: LOISS; iOITl; |
1 a tins: coBpiBinn XTUVMICIS; stt; \
1 1C1ZBSIC BIC1CIII |
1 1
a) 37.2 ng/g Mt vt la) lorker I HyoSo, x.
b) Bot given I b) Controls ( Saioki, s.
1 1 rnrnya, B.
1 JicauM vorkec. 61 vr olo, at 1 Besai*«ka, X.
1 caroaate [rodacing plant for 30 yr. I 19BO
1 tied of nezillarr and lung cancer. I International Urcaives
) Centrals, 59-78 vr old. I of Occupational and
1 1 Znviroueatal Health
1 jirjn- IBTJOSI tissai; IOITI-. mm i ««:i»i-iso
< BlltOf; BBtll: CnEBtllDB; CZBIBBOB; I
1 KIlBEtS; IITFJ: LOBSSj BBSC1ZS; I
I IIBCllU; SXIBi CBKOItBB: COPPXB; I
1 Bints-, tixc: icggstiiii. nms; i
1 IIBIlinOB: CCCOV1TIOBU UZ1IDS; \
1 POPOUTIOI BIPOSB1E t
1 |
1 |
a) 22.2 ng/g Mt vt | i) larter | Byodo, X.
b) lot given | t) Controls \ Suzuki, S.
t 1 Parori, X.
1 Jatanase «otker, S5 yr old. at 1 Resfciiakn, X.
1 catenate cretacing plant for 30 vr. 1 19(0
1 tied of aaiillarr and lug cancer. I Ivtenational Uehives
1 Centrals, 59-78 yr old. 1 of Occapational and
t 1 ZBVlronnental Bealtli
1 »I*Bi IBIMSI tlSSBZ; »OBT»J 10(3 I »6:1«t-15(l
1 BlltOT; BI1IB; CnCBZLlOB: CnXBSDB: I
1 KIDIBTS; Ufa: HISS; BOSCIZS: I
I mcit is; SIM; craonsa: cotpii; i
l nnus: me; n&nsTBtti nins; i
l iiauutait cocnrmoxiL utiios; \
1 ECPDimO* XXPOSOI9 |
1 1
a) 10.1 sg/g Mt «t e ,} lorker I Brado, X.
M B»t given | b) Controls ( snvki, s.
1 1 mrayt. 1.
1 Jatanese worker. CS vr old, at I Beshiznka, X.
1 tfttonat* rrodnclxg plant for 30 yr. I 1980
1 I ltd of sutllaET »& l«ag cancer. t International archives
1 Centrals, 10-71 yr old. 1 of occupational ua
1 1 Znvlronsental Health
1 31t»; 1DIPOSI TISSUE; IOBT1; BOIZ 1 »«:1<1-1SO
1 BlltOt; BStll; CtBZlZLIN: CnZESDB; I
1 xiEins: n»n; inxes; ivscus; \
t (IKBZlS: SIM: CB10BTOB; COPPIl; I
t atTtis: sue: IWDOSIBIIL puns; i
( IiaillllCB; QCCDPKTOBU. BIIlltDS; t
1 fcpouTion txposomz i
                                                                                                                                                                                      SO
-------
Tlie
ta
Itl «5.38, H» (19.5 C, B* 908 c, « 1 aa Bg at 4«7 c. 10 en Bg at 5*0
tissus BXfosBi: TOUTS IIU.TIICU.
BZT10D


•COS I-ra- apeetroe
Spinal
cord









1
1 1
1 1
t 1 l
t 1
««o« I n
Spleen f
(



f
f
t 1
1
1







1
1
1 ««07 IIS
(OllZt | »iei 1 nil | 6BI1UL mCIMHOI 1 BZmBBCZ
or cisKS lit i
1 1 1 1
) 1 1 1
a) 7 |a) 39.6-202.5 og/g I a) 83.8 * or - it. 3 | a) Solar nenron disease patienta 1 Karlander. B.B.
b) 12 I b) 3».6-85.9 ag/g 1 ug/g I t) coatrala 1 Sattan. B.I.
1 BIJ *t 1 b) 52.2 * or - l«.3 | Tvatral kora tis-ae. aatopsi 1 1979
1 1 og/g I 1 annals of leitologr
I | arr vt | fatieata died of avotrepklc lateral 1 *(1)t31-24
1 1 1 fclerosts aad progressive aasealar 1
1 1 1 atropkr. aean age, 5«. 6 « or - 13. 1 1
1 1 1 It. Control! died of varioas 1
1 1 1 diseases at 60.9 « or - 11.1 vr. 1
1*1 1
1 l i TIII-; iBoiiss lororsiss; i
1 i t M-KOTseoiai vz-Bi-xs) srnu. coio-. i
1 i i tioicciTioniiof : CJUCIOB: COPFBBI i
1 l l itoi: itic: ureaixsz; anus; i
1 1 l SniBCTI: ZlfC |
i i i t
III l
a) 9 | a) C.S-45  120 I Salsiaen, B.
1 1 1 41 50 | d) 122*282 og/9 1 d) '85 * or - 10.8 | a-/g ta IB acil 1 1981
1 1 1 e) 26 | e) 143-339 ag/g 1 ag/g [ c) Bentine, arbaa area I Ircblves of Oral
1 1 ( f) 26 | f) 169-538 ag/g | e) 1*9 » or - 20.4 | d) tMael. aa in (a) 1 Blologr 2t:1-6
II II «g/g
1 1 1 If) 301 « or - 42.8
II II ag/g
1 1 1
III 1
III 1
III 1
1 1 1
i f i
i i
i f
i

4C08 Xftgeatian US a) 15 a) lot girca
Triae b) 17 b) lot given
O 19 c) lot girea
d) 15 d) tot givea












t
l -










a) 539 » or - 355
ug/2* br
b| 522 » or - 288
•9/24 kr
c| 343 » or - 222
-g/24 kr
4) 127 * or - 251
ug/24 kr










e) Inaael, aa la (b) I
i) laanel, aa in (e) I
latiaated free grapb (a,b,c) |
lg< depeadeat data al» presented. 1
la accacalated la dentine np to age 1
if 1
1
lesideats of Finland 1
1
niltni 10!; SEX; T.KTB; COBP1BHITE 1
ITlIOlTIOirS: BIOMSW1; Tile; SDMI I
JSI1S; K1B» 1BZ15; BBT1IS 1
1
a) Me. lov (load preeeore 1 aer.ea-ie, J.B.
t) Ma, klgh feloed pre-nre I eathrie, I.I.
c) lonea* lov blood presaare 1 Prior, 7.JI.S.
4) voaea, kigh blood presaara 1 1978
Subjects selected by Uood ptessore 1 taerican Journal of
rank fcon previoas stndr. Bstinated I Clinical ntrition
dailr iietari intake 4.5 ng. I 31:422-428
1
folvaeslan residents of Tokelaa t
Islands, cro«del eoaditions, 1
subsistence econonr. Ben, n«an age 1
1! Tr, aean lit 147 en, ne*n vt 74 kg. 1
leaen, aeas age at vr, nean kt 165 1
ca, aeaa vt 79 kg. 1
1
CCEflE; IT«C: BIOOO SIBOS; I1IB: 1
tins; Mill; 1Z1 ZEU1E0 I
1
                                                                                                                                                                                   N5
                                                                                                                                                                                   O
-------
Stic, Kltr<»?«a 3,7, 12, 17-t«tra»athyl-8, T3-Uiiadiproplo«ata<2-||- (8 CT)
*l»c. n.12-ai»tlienTl-J.8.13,17-t«tr»»«thyl-21S.23H-porphiBe-2,H-dipropiiioato(2-)-I(2I).«W2),I(23|,»(2«»)-.
C3«-H30-M-0«-In- 21
II 626.03
TISSUI

»609
Iloot.
call*













Eiiosvn IOOTE
















>B»1IIIC»1
BETVOD















WSBHI
OF MSB
2«0














iMGS

a) lot gl»a»
b) lot gtT 3V 33 vk aftai caaoral
trrthcoeTtas
(atlaatad frea araph
Cavaldarabla dlt£«t«moa la rata of
ebaiga aaa plataaa stata for Xa
Iaa4 saaltai torkars
ItntlS; BIOOD; MTTHBOCTTIS;
CC9F1B1TITE tTHOlTIOIS; USOSTtlll
iicinit mi: xnc OIGHIC
ccnposins: iieosmsti itiasraEits;
IIBIUTIOI; CCCBPlTHWil BiJWDS;
SRIITZIS
SSfEBXICE

Baslay, E.I.
llabisk, S.B.
1991
Journal of fba taerican
Inanstrlal Byqiena
l*sociation »2:«2-«6










 rlcconlgi
 7»»0-67-7
 It
 Id 91.22. IIP 1852 C. BP 35T7 C
TISSDC

Bale
















IIPOSOBE son:

















t
lutmcit
BETBOD

















IOBBSB |
or CISES

















11I6E 1


















1Et(


















fillllll I«roBB»TIO«

Vavia»« 2V caprasaata,tiTa
pra-a*alT»la tr«ataants ara
tatnlataa. Iba faacibllity of a
bcllatle. no-«a»h policy for hale
laalysls 1* outliaaa «ad supported.
f If III; TB1CI I1HEITS: Bill;
IDSTBllH; >IlSOIZR»t IZIBODS;
»11LS; PBOTHIS: COMIUTITI
IViLV&lIOVS; 1L0BIVQIC; 1I1TBOIT;
»siuc: Slim; BKonil: CICFIIDS:
ciicnn; CKOBIIZ: CBBOIIOB: coiui:
CCPPEB; Sllliai; GE1H1IIOH; £010;
login; iBon; tiRBma: nit;
MGIEStVl; BlIGUKI; BIBCUBI;
tatmimn; HCKBL; CBOSPBCBOS;
fQlaSSIHH; SDBIDIUB; SEIEVIQB:
siiicoi; suns; SODIIB; SIBCSTMH-.
soiroB; in; Tinnm; tuiesni:
II1C; ZI1CCII1IB
BEFEIEICE

Chittlaboroogh, G.
Sctaac* of the Total
tITlXO*MItt 1*5 53-75














                                                                                                                                                                                           N)
-------
     1-eataaol. J-**»rt-
     C«-B1«-0
     II 102.17. If -tS C, SI 1»8.9 C.  TP 9.9 •• tl it »  C
tissue

»S11
Bre«t»












EIKISVB BOBR















IBIIITICIL
HCTBO9

8C-HS













BOMS*
or cisss

5* (387
saaples)












11(61

Vat 9lTea













8MB 1 C1BZB11 IVFOIUTIOI
1
1
t
1.12 B«/l ( Beanred at 25 C aad 760 II Bo
Ceoaetric | »S.S* ooearmee
1 ze»«r aa& apper osw-sigaa Jiaita
1 C.370 aad 3.3» aoyl

I BMlthr. i*-3S rr old. B«an>)ri«9,
1 «rtia black* »»4 caocasia ni.
1 cficaqo, 11. BtqWlT co«troll«l
1 «ip«rlmttl co«ditia».
1 III1TB; IICOEOIS; II1IIOIS; tDHUS;
1 ciiatinrtt mtocntoiss TOIJTHI
l ciemc coircojDS: mm HUIBDS;
i IHIUTIOI; mimisa; uiiaoims;
1 FCFBiirro* nposni; JBBI» IBIIS
tETEIIICI

Kcota«ia i »
                                  at ixs c
Tissm
««12
Breath




1
1



I
1
1
1
1
1 siresms aonz
1
1
,'








1
1
l
1
l
1
i
iBunicii
HXTBOD
OC-9S















•0SBSB
or cisss
W (387
saaples)








1
*

1
1
1
1 BiBei
Bot give*











1
1
1
1
ms»»
12.3 ag/1
Geoaetrie














6BBIBU IlrOtUTIOB
Caaanred at 25 c aad 760 aa Bg
?.»* oecarrenc«
lower aid afpec one-stga« Halts 3.*3
11 <5 *1.8 aq/1

Bealtkr, 18-35 ji old, nonsaokin-g.
Qttaa blacks aad caaeaatana.
Ckicafa, II. Blaldlr conttoUed
•xpcriveatal coaditlons*

HUTt; IICCBOLS; IILIIOIS; IDI1TS;
CBLOBIMItg JIBSOCJBBOIS; TO II TIL!
CIGIHC COStCJKDS; BE1ITH BIZHftS;
IIB11ITIOI; BtTtBOLISS; BB11BOLITZS:
KJTOUTIOI taosnsi UIBJI 11:15

UrBBKBCE
Krotosxiulci, B.K.
Brnaeaa, Q. B.
O'Seill, g.j.
1»79
Journal of Inalitical
loitcoloqr 3:225-23*










                                                                                                                                                                                           to
                                                                                                                                                                                           10
                                                                                                                                                                                           ro
 1>Bat«a*
 10»-»8-»
C«-»8
B* 5«. 12,  IP -185.35 C, BP -6.3 C,  »P 3*80 aa B« at 21 C
I 1ISS»
1
1
•613
Breath










tirosvtt tons












1 IBlimOL
I ireraoo
OC/HS











BUBBH
OF C1SES
8











81HSJ
Bot detectcd-510.0 og/hr











RE1I
78.8 ng/hr











GM1S11 HfOHlTIOI
Ccapond relates to iroraal
tetabolisi. Ho other detaili giTen
Cirogeaic sampling teckalgne.

I«altbT lilltair and clvillail
eiployeea, o.s. ilr Force school of
Mtospac* 9«dlciM, aqea 23-*7 ji. 3
stokers.
tllZMXS; CaiOBIBaTlD HTDBOCHEBOIS :
CElOBtH! OBGltTC COBTODIBS;
cEioioBHiiiiis: naoaiK cosiovins;
IS! KB: ILCOtOLS: THUS; AUDITS
KFIBZBCI
Coakle, J.F.
Caap, B.J.
Reich, B.E.
1975
archives of
EnTiroeaeotal Health
30 mt 290-295





-------
I07-00-S
C«-B6
If 5», HP -130 C, BP 8.J C.  TP 100 M Hg it -«.* C
TISSBS
«1»
Breatt










8IPOSBSB Bom












tlltTTICJL
BET HOD
.
ec/ss











IHIBIR
or cisis
s











MIS:
lot detect«d-3.* ng/hr











1E1I
0.« ng/br











critiit nroiiuioi
coapomd froa ukaon orlgla. la
ctfctc to tails given
Crroq«iic KipllD? technique.

KalthT illttarT ail elrillai
•?ploTB«5, g.s. lie farce School of
leroapac* n«dici»», ag«s 23-47 jt. 3
tiokccs.
ItlZElIS; CBIOTI1»TZD 8TDBOC1SBOIS ;
CE10BHB OIG1HIC COHPOnOS;
C8IOBOBHIIJIS: nOOIIK COSPOB1DS;
EI1IIB: 11COEOLS; THIS; 1D01TS
SZ/E1EICB
Conkle, J.p.
Caapr B.J*
Belch, B.t.
1975
IrchiTes of
EBTicountal Besltk
30<2>s290-2W





1-lexuetbiol
111-31-1
B«  119.2*, HP -B1 C, B? 151 C
TISSBB
•«15
Breath












EIMSTJES MUTE













iiiimcii
nilflOD
ec-Bs












•BBBSt
or cisss
5« (387
ncpLes)












B1BGB
lot given












Kill |
1
2.2 ng/1
seoaetrie











1
email nroaauioB
B«aaaced at 25 C ami 760 >a Bg
15. a* occamace
Lc»«T and apper aa«-sigaa Halts 1.0
•id *.« *q/l

BcaltkT, IB- 35 it old, aonsaolcliKi,
gctaa blac\s tad cavcaaiaas.
Cblcaqo, 11. Blgldlr coatiolled
•ipcrlaeatal coadltloas.
tlBlTB; tlCCBOLS; ItUIOIS; ID01TS;
tFLCSIlHID ITDBOClBBOBS; TO11TH.I
CSSIIIC COBPCOTDS; BI11TK BaZttDS:
1IB1UTICI; UTIEOIISB; BII1EO1IMS:
IC?m.»TI01 IIPOSOSE; BBB1B IBI1S
similes
Kcotosilnskl, B.K.
Bcaneaa, G.a.
O'Beill, B.J.
1579
Joacaal ot knaljtical
Toilcologj 3:225-23*








                                                                                                                                                                                           N3
                                                                                                                                                                                           U)
  10»-7«-7
  «-S1l-0
  BB 130.22. B! 18*-1(S C
1ISSUB
16 1«
Br«ath












KIPOSOK FOOT!













ivaimcu.
BBinOD
SC-BS












10BB55 |
OT CISIS
5» |387
aaapteO












BUCK
*ot  Bq
17.6* occurr«nc«
Lo««r aad upper oae-slgaa Halts 1.3S
aid 11.9 iig/1

B«alt«T, 18-35 TC old, aonsaokinq.
ntlao blacks aid eaaeailaai.
Chicago, II. Ugldlr conttolled
iipaclxntal coadltloms.
EBfHB: ItCCBOlS; IlLIJOIS: JDItTS:
CBlOIinttD BTDBOCilBCUS: (OUTH!
cieinc coBTcmiis: BB*I.TH HIT»BDS;
IIB4I1TICI; KRItOlIS!!: aZIUOUTZS:
tOPOHTIOB BUOSOBB; 1BB1I IHaS
tmiEBci
rrotosznskl, B.K.
Brnneao, G.a.
O'»«lll, B.J.
1979
Journal of Inalrtlcal
Toilcologi 3:225-23*








-------
     1-0ct«w. 2-Mtkyl-
    t»-B18
    n 12S.27
tlSSTJB

•617
3raatk












smsoBS Bonn















imiricii.
BITBOD

OC-«S













itmm
or CISTS

54 (317
saaplcsl












BIIGI

•Ot ppw OM-S19M lilitl 0.83
lid 5.3 *q/l

!««ltbi, 18*35 Tr old, nonnakint.
ait« blicki *nd e*ae»i*n<.
Cbiciqo, 11. Btijldlr controll«a
-------
1-Peataaol, 2,2,a-trUflthTl-
1S3-O-*
C8-B18-0
II 130
TISSUE
»620
Breath








"




IIPOSOBS BOVTI














IHLTIICit
mama
GC-HS













IOSBEB
or CUES
5» (387
saaples)













XilSE
lot givea













ftKll
1.2 nj/1
Seoaetric













GEIHaL XnOSRaTIOl
ecasored at K c ana 760 •> Eg
»7.«1 occurrence
lover and offer one-Si gia liaitc 2.2
aid 7.9 »q/l

Bealtty, It- IS yr oil, Boaiaokiaq.
atlM blacks and eatcasiaas.
Chicago. 11. BiaLdlr ontrolled
ciptci natal coodltina.
E8IHI: 11CCBOLS; IlLIIOIS; IDH1IS;
CaiOIIltTZD BIOBOClBBOtS: TOUTILE
CISXIC CC9ECOIDS: ailllH mZHDS;
HBlUTIOl; BETIBOLIS9: HIT1EOLITES;
1 fcsonttoi inosoai; IEBH u»s
1 	 ; 	
EtnmcE
Krotoszjasklf B.K.
Brwean, 6.1.
O'Mill. a.J.
1979
Jotirnal ot analytical
Toilcologi 3:225-23*









 1-P»ntene
 109-67-1
 C5-H10
 »» 70.13, 8P r12» C,  BP 30.1 C,  TP  «00 •• Hg at  12.S C
TISSUE
11621
Breath










tMOSWE SOME












antmcai.
BFTHOD
GC/HS











IOHBSB
OF C13SS
8











sues
lot detected-ISO. 0 ng/hr











an*
3».1 ag/hr











sEtraiz. i«rosaiTica i
Coapoud related to aonal !
MtaboUsi. (o other details 
                                                                                                                                                                                           to
  1-Propanol, 2,2-dttethyl-,  acetate
  926-»1-0
     130.18
tissn«
««22
Breath












! IPOS US? BOOTI













JlULITIClL
maoo
ec-«»s












IDHBa
or cisis
54 (3B7
saiples)












BHSI
Vot glien












H21I |
t.» ng/a
•Jeoaetric












CtHEll HT01B1I1CJ
ecanrel at 25 C »nJ 7«0 mi sq
38.8V occurrence
Lcner aal apper one-Siqaa liiits 0.86
and *.l na/1

IKalthr, 18-25 rr old, nonsiokiiig.
irtaa blacks an 4 cancaslaiia.
Chlcaqo. Tl. BigidlT controllea
ezperiaeBtal coaditiofta.
IBI1TB; HCCBOIS; IllIIOIS; 10DLTS:
CElCBimTIO IHIEOClBBa»5; T011TIL5
cisinc coBPcnos: BIIITH HIUJDS;
UBitiTici; BZTaroLisa: BEIIKII.IIES;
fCFUtlTIOK IIPOSISE; IBBal IBEIS
KtttZtCt
Krotosrinsfci. 9.K.
Brtraeaa, a. a.
C'leill, B.J.
1979
Joaroal ol analytical
ToilcologT 3:225-234








-------
 1,3-tropaBVdlol.
 ST-S3-*
 C9-SW-l2-Oa
 «t 2t«.2S. at 10«-106 C
nssvt
•623
plant



ntromc ions
laoaatioi




iiumcu.
RSTBOD
ec




mrnSI
or cuss
i




iue>
12.S-7 ag/al




nil
lot applicable




CEIHII nrosiuici
1 aa< « lr aft*r SOD a« i> aolntioa.
Xaitial nlaa, 12 «-crclob*ta(cd>)p«BtalM«, 1,1a,2,2.3,3«,«,5.5.5a,Sb.«-4od«c«cWorct«kraro-
33*5-8S-S
C10-C112
SI ««!.«, IP (85 C,  TP CIIO(I-C)  u ng at SO C
1 iissnt i sxrosmt totrti i intmciL
1 1 | IRBOO
i i
1 i
•(» i ec
aAipom I
1
1
1
f 1
1 I
f I
I
1
1
1
1
1
1
t
1
1
1 1
»0»!SS IHGI 1 BK1I 1 CEIIUt IlfOIBlTIOl
or cisss i |
i i
1 |
M» •) lot 9i»« 1 a| 0.172 » or - 0.937 | •> !«•• 9-1* yt
b) lot ji»«» i pp» | tj >?» 15-M rr
c| lot jir«o | b) 0.2«3 * or - 0.039 I e) !«•* «5 Tt or >
4) lot «ira | ppa ) ') Ust Sottt caatral ceatts
I •) lot glim | e| 0.297 » or - 0.077 | •) Sotta Itlaatie cams
1 f) lot aim | ppa ( It Mat Sovtb Caatral cersos
I g) lot glna I d) 0.292 t or - o.oig | q| caacadaaa
h) lot gtT«n | ppa I b) loa-ca«cab •) T - IlpiJ axtractatla
1 ppa | lataclal a41«tad. Ml«ate4 iata
1 fl 0.252 » or - 0.03D | taaaft on alta« Spwlal Study, ri 7«.
1 »Pa | liaitations cf aaaplc Mlactlon
1 h) O.«06 » or - 0.102 | ntaotolaw r»atrict iitarpntatton
1 opa | cC cvaalts.
f 1) 0.322 * or - 0.085
1 PPa Simlcal patlut* aid eatarata in all
1 1) 0.2«9 • or - 0.023 eoaatlai >itt «ir«r as* aarloo 10 TCI
II II I PP» u, re. ai. n, «s, ic, sc, 71.
II II 1 S.I.
II t 1 1 OeoMtrlc ««i* lUBJtll; n.01191; GK3BSH; lonisiila:
1 ' II 1 HSSISSirPX; K>»TB C18O.III: SOOTH
1 1 1
1 1 1
1
1
t
1 »625
I tloot.
I »bol»
1


















t
1
1 1
i SC-BC
l
1



















I
















») 3S
b) 12

















1
1
i
i
I CICOtlll; THIS; UIKSt II5S02:
I IHSICTICIDBS; Eioicccrsouuoi: rooa
1 CCITMII1TIOI: PBSTICIDBS
	 1
1
a) lot 4et*ct*d
b) lot 4at«cted





















a) lot d«t«ot«d
b) lot dctvcteil




















-


a) toTa Caaal r«aiA«ata
r) Tolaateaxi
Halt of a«*tar«a«Bt, 0.22 to/v
Cloaalr aatci*3, iia«lt«a«oia control
taatlas oera aot prortieiJ for
• minis alcaq alta those ttoa tt« 36
lera cual ares rcsiiaats a»apl<4.
lactlif eeaaiaqfal control or
litcrttare data r«litin to ti»
sl?aiflcanca of ta« lo« raaldvaa
tctti la ta« field «aple» aialmd.
no 4efiiit* coaclaaloas caa ba oravii
froa tk« tssolts c«ported.
Kaidvats of lav Tork. Controls,
aifloToas of ta* SBTiroiMatal
Trotectloi IOABCT aid mltorsiti
stoieata, lorth Caroliaa.
Ill TOBK-. ICRfl C»OU»; B1009;
BHSOEMI1T IITBOOS! CBWBIII OJGIIIC
CCHOOnS: CBIOJOBIIIIISS;
iiiiciLoicBinns: poLTcatosinTro
IIIHItLS; TWVL1TIOI IIKPSUBE

S»EIE*CI

taiaiaqer. C.
•atta, D.
sptraeiDO, C.
Illliau, S.
i»sa
IPS 54«/!3-«O-02«, (08
pp.





















rlatol, 0.1.
180
P1-600/1-80-OJ6, «0
P.



















                                                                                                                                                                                         u>
                                                                                                                                                                                         N>
-------
1.3,«-Betheno-2H-CTClobuta(cd|pentalan-2-one,
H3-SO-0
C10-C110-0
II MO.68. TP OI10CB-71 •• 84 at 25 C
                                                ,1a.3,3a, «,5. 5,5«,5»,C-o:ec«cUorooctaaydro-
TISSUE
*626
Blood,
•kola


























KXFOSmi BOOTI





























ininicu
BKTHOD
9C




























IOBBJS
OF CASES
tea




























UI6I
») .009-11.1 ppn
b) .003-*. 1 ppl
e) .003-0.39 ppa
d) .003-0.45 ppn
•) .003-0.031 ppa
f) -OOS-O.OH ppn
g) .003-0.00* ppn
h) 0.005-0.0325 ppe





















mi
») 2.53 ppn
b) 4.60 ppn
e) 0. 10 pp«
4) 0.06 ppi
e) 0.011 pp*
f) 0.008 pp»
9) 0.0035 ppi
h) 0.011 pp»





















6KIIHL IIFOIR1TIOI
«) ST ill •i;loT of Lif« Scl«aca
Prodocts Co
b) »8 nuffacted aiploy***
c) 30 £«iilT MBimrs of aiployets
d) 30 employes of llllvd Che*ical
Ccrpor*tioB pnvioislT In Icpona
CIO duct ion
«) 23 aiplofMs of uearbT b*sin«ases
() t saraq* tnataent plant enployees
q) 2 cab OT truck drlnrs
k) «0 residents within 1.6 1» of Life
Science frodocts Co
Besldants of Hop«well, Ti
Significant difference In frequency
of irnptoaa In kepome vockecs aa
ccnpared to area residents: Bashf
•ervananess, teesor, Tlsnal
difficulties (p<0.001), plvuttic
tain and velqnt loss, (p
-------
1.*:;,8-DlsetkaBmapktb.aleae, 1,2.3.*,10.10-kaxacttoro-f.«>*a.5,*,*a-kex*kydro-. eaido.exo- (8 CI)
1.*:$.8-DiaetkMoaapktkalene. t,2.$.*.10,10-kexaCaloro-1,*.*a.S,8,ea-bexabriro-. (1alpaa,talpka.4abeta.5alpka,8alpaa.tab*ta)-
3C9-00-2
                                                                                                                                 CI)
B» 3«5.tl, RP 10* C, TP «I10(E-«)  an Bg «t 25 C


























«ISSITB



IC28
iMlottc
fluid










*«29
Blood















«*3o
ni tt







i
«
I

I


•631
Placenta











»6S2
Placenta














EIPOSTOZ son

































IftOestioa






aitiTTicai. i IVBBS> i tun
SEtHOD J or CtSSS I
1 1
1 I
9C-K ( 50 1 1-152 ppb
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1

1 1
1 1
1 I
OC-IC 1 t) 25 I 4) lot 4et«ctable-23 ppb
I b) IS | C) 9-80 ppt
1 C) 10 |e) 18-70 ppb
1 1
1 1
1 1
I 1
1 1
1 1
1 1
1 1
1 1
1 1

( 1
1 1
1 1
oc 1 a) 21 | a) tot detected
I b) 2« f b) 0-0.0*0 pp«
1 c| «5 1 CI 0-0.0*0 ppa
I t) «5 I 1) lot given
1 1
1 1
1 1
t 1
1 1
1 1
1 1
1 1
1 1
( 1
1 1 1
1 1 1
1 OC-BC | 50 I 2-1587 ppb
1 1 1











C















1 1
I (
/ I
1 1

1 1
1 1
1 1
1 1

I |
1C- EC | a) 2S | a] lot detectable- 15 ppb
1 b) IS | k) lot Jot ectabl e-110 ppb
1 e| 10 | e) lot detectaUe-2* ppb
I |
1 1

1 1
1 1
1 1
1 1
1 1
1 1
1 t
1 1
Bill 1 GEIZIlt XimMIIO* 1 IWMEICE
1 1
1 . . _ 1
1 I
20.76 ppb 1 18 posit IT* speclnas 1 Sarena, I.e.
Geoaetcie 1 | Sett, T.P.
1 Pregnant reeea. similar in I Bahajaa, f.L.
1 sccioecoaoaic level aad dietar? | 1980
1 babits. 10 oceapatioaal or i Intinational Joanal
1 accidental exposare* lacknov, Xodia f of Znvironatttal
1 1 analytical clieilstrr
1 FIST 1C ID IS; CatOHItnO BTCSOC1BBOIS; | 7:2*5-751
1 CBICSIJ! OBSJHC COJIPOOIBS; EDI; 3DI; 1
1 IDT; IIDI1; EBESIUCI: IBIIOtlC 1
1 J1DID: PHCIIT1 1
1 1
i r
a) 11.1 * or - 7.3 I •) Co*trolit fall-ten pre;ia«cle< I Sanaa, I.e.
ppb I t) Pre-teri fr»Ua. I 1*81
1 1 Journal of analytical
1 !•«»: IBOBlioi: 1DOLTS; rnos; I ToxicologT 5:<-*
I noci: Piactni: COBPIBITHF i
I tmamois: cuotruTta i
| ItrBOCaSSCIS; CB10XII! OROHIC 1
I COCCOIDS; I1SECTICIDIS; PISIICIDES; 1
I rtsnciDi stsiooBS; popuiiiici i
I jitosoBS: piteiiicr «
1 1
1 1
a) lot detected I a) Siral icthers, fat basia 1 Pozo lota. t.
b) 0.00* pp> | r) grbaa setters, fat basil 1 Becrera Barteache. 1.
c) 0.003 ppa 1 e) 111 aetheia, fat basis I Polo rillac. L.B.
d) 0.0000* ppa | d) 111 aothets, saol« silt basis I loper-Cieenez, 8.
1 Oata for mi of all pesticides aid 1 Jodral Tillarejo, B.
1 ceiparisns sltb rallies of otker 1 Iglesias Perez, J.
1 lavestlgatore aiven \ 1979
1 1 Bevista Espanola d«
1 »n rains aothcrs free Cordoba region, t Pediatrla
1 3Fai> 1 J5(20S):»3-11«
1 1
1 sftj»: tmiTS: si«: CBLOBHI oieinc i
I coipooioj; ptsTicnts; IGBICOIIOBE; i
1 ID11L lltIS; DRBlf USaS I
1 1
1 1
158. 7 ppb 1 «« poiitiY* ipeciie«« 1 Saxena, B.C.
se«etrle I I Setk, T.B.
1 Ere«naat vonan, aiailar in I Bahalan, P. t.
1 locioecoionlc lerel and dietary 1 1*80
1 babits* lo cecapational oc I Tateraatienal Journal
1 accidestal «rposare. luctmo*. InSla 1 of Cnvicouaatal
1 1 analytical Chealstrr
1 CISTXCIDIS: CBLOBIlim BTDWCUBOIS; I 7:2*5-251
I CBIOBUE 0161IIC COBPOH1DS: toE; DDE: I
I ItT. IIDI1: PKB6IIKT; IBIIOIIC 1
1 line; pLjcim i
' 1
1 1
»1 » or - 3.96 ppb | a) control!, fall-tern pregnancies 1 Sanaa, B.C.
17.9 « or - 2«. 1 1 t) Pre-tern tregnanciajs 1 Siddiqai, B.lt.J.
>b I cj spontaneoas abortions at l*s* tbaa I Setk, T.D*
IS. 9 • oc - 7.6 |8 «k (incudes fetas) I Xrisbna Bnrti, C.I.
pb t 1 Bkargaia, a.K.
1 Bealthy, non-exponel, pre^iant aonen. I Rntty. D.
1 age* 18-32 yr, ladla. I 1981
1 1 Journal of analytical
1 lIDIa; aBOITIOl: 1DOLIS; moS: 1 Toxicology 5:6-9
1 nocoi pxtCEnt: coiPiunn I
1 fTllVaTIOIS; CBLOIHUZI 1
1 IHBOCUBOIS; CHIOEIK OXGI1IC \
I cciiomis: iiSECticnis; PESTICIDES-, \
\ tISTICIDt BlSraVBS: VOIBLatlOl 1
11 t 1 IMOSUMt fltetlKT (
1 1 1 __..... 1 1


































OJ
M
oo










































-------
1,«:S,8-Dinetbanonapktkal*M, 1,2,3,a,10. 10-nerackloro-«,7-«pOT7-1,»,»a.5,6.7,8,8a-octanT4ro-. «uoo,«xo-  (SCI)
2.7:3.«-Din«thanoaa?hth(2.3-b)oxir«lie, 3,«,5,6.»,»-b.«iacliloro-1a,2,2a.3,«.«a,7,7a-octabTtro-, (1«alpha,2b«ta,2aalpha.3b«ta.Sb«ta.6aalpha,7bet»,7«alph«)-  (9 CI)
60-57-1
I* 380.93. BP 176-177 C, TP 7.78X10(1-7)  » 89 at 20 C
TISSUE



•633
Idlpose
























*63*
adipose










•«J5
Iniotlc
fluid








rosns SOOTS




















































lULTTICaL
BET HOD




























GC











SC-EC










RUBBER
or CISES




























60











SO










UEGE





























<0. 05- 1.16 ppa











1-3 ppb










Bill | GEIllaL IlfOSHlTIOB
|
1
1

J
1 Exposed persons in the United States,
1 the «ether lands, Sweden, Israel,
1 Japan, OSSB, Poland, Geruany, India,
1 Evlaarin, Pakistan, Austria.
1
1 Beported cases of hypertension.
1 elevated serin ckolesterol. abnornal
1 lies, or iipairnent of neareauscular
1 function after acute exposure to
1 conbinations of pesticides, bat nost
1 datn show no aSnrs* effects after
1 Icnq-tern occupational exposure.
| IDSTBIa? BOXGlBIl: GBRRaEY: X1DI1;
| mm: JlPtl: IETB1JLMDS; PaKISTW;
I ICLMD: 1DSSI1: SVE9EI; BIITED
I SHIES: tDIPCSE IISSOE; B1OOD: BLOOD
| tUSHa; BIOCO SEME; EITTBEOCTT1S-.
| ItmoCTTES; BI1K; DBIBE; K1TIEB;
I BIILTH HIClBtS; OCCOPlTIOlll R1X1BDS;
I topniTio* EXPOSORE : IEOPIISRS:
1 CISnCIDIS; CEXOBIIE OBGallC
1 ccRponas
1
t
0.26 ppu I Peripheral kidney fat, routine
1 cntholoaical exaninations
1
1 Iges 6 no-92 yr. Belgian
1
I t»sim: iDTopsiES: IDIPOSS nssas:
1 EIOlCCqilUlITIOI; PESTICIDES; DDD:
1 ICE; DOT; DIILDKII: BBPTICHLOB
1 ItOSIDE; RSXaCnOBOEEEtSlE: URDUS;
1 CrtCIIRS OR61RIC CORP001DS
1
1
2.«2 ppb | 2 cositi*e specinens
Seonetric I
1 Vreqaant voaea, sinilar in
1 tccioecononie leiel and dietary
1 tab its. 10 occupational or
1 accidental exposure. Locknoi, India
I
1 EISTICIDtS; CHLOtnUTID BTDBOC1SBOIS;
1 CCIOSIIS OSGI1TC CORP01KDS; EDO; DDE;
1 CCT; n»It: PtESRllCt; 1B«IO«C
1 IIOID; PlaCtrta
lEfEHERCE



Deichnann, f.B.
RacDoaald, I.E.
1977
Ecotoxlooloay anfl
EnTironnental Safety
1:69-110




















De^onckheere, V.
Steurbaat. I.
Tecstraeten, E.
Kips, B.I.
1978
Toxieological European
Besearch 2 (2): 93-98





saxena, H.C.
Seth, T.D.
nahajan, i.L.
1980
International Journal
of EuTlronnental
Inalytlcal Chenistry
7:2«S-2S1



                                                                                                                                                                                           LO
                                                                                                                                                                                           ho
                                                                                        (HIT
-------
1.«:S,«-VlMtkUMtpktk*l«M,  t.2,J,«, 10,«»-a««clil  3,»,5.6,9.^-fc«l.ckloio- ta,2.2»,3,8,6«,1,7.-oet«kTteo-.  ll««lpi«,Jt>«t«.3«alp»»,
«0-!T-1
C12-1I-C1S-O
«t MO, tj. IF 17«-177 C, T* 7.7*««(M> u Of  at 39 C
a, H>«t.,6..1pli«, 7b»t«,7«.lpi4) -
                                   CI|












































1
l_
IISSBI

«3«
Blood









f










««J7
Slwid,
cell*






1
f
t










»tos«xs to













































l»tRXClI,
••MOO




























»















IWBSI
or cuss












































MKX













































i RUI
t












































EEftut matnnat

Kile*

trroae4 (wcicta ia tie 9aite4 States
tke letaerlago*. Snjaa, Iiraal,
Jipio, 7SSB. Polaad, saraajf. Itdia,
6«fact«< caa«4 of aYP*ct«aaiGa«
1 elevated eecaa caoleaterol* abadnal
I ties, or lipairaeat of (eareaaaealar
1 faactioa aftec acute aiposuta tp
1 caabtnatioaa af peatlei&ea, tat aost
1 iata aao* ao adverse effect* after
1 lc»«;-tecai occ«p«Uo»al exranre.
I lusTBii; BDtsisii: extdiiT: HOTI;
I ICIUB: SDSEIl; SIlBtl; MltllD
I mns: witcst nsstrsj steccs ttooc
I Hijtocrrss; HIE: aiint: ss7iia:
1 E111I3 HH1EIS; DCCUTiTHUU SUlttDS:
I FCPOHTIO» IlfOSffBE: HOPtJSBJ;
| ftS^ICI»!S; CBIO«»! OtCllTC
( Kt fOaltS: lIOTllSiS; PISI1CIJBS;
I cncem OIGUIC COIPOHBDS
i
1 *«!av
1
1 tipo»4 p«t»ots la tM anitad states.
1 taa Ketherlaada* Svedea* Cacael*
1 Japan. OSS», Poland, Secaanr, India.
Eolijarla, Piklstao. Hatrla.
B.port.i oaes «f ariwcteB.ic*.
!!5s. or iapatraeat of aeireanacajar
(aaetlag alter aeota etooiua ta
ccabittatitfa* of peaticid«av bat a0at
Jata ako» vt aAvetse effect* aftec
leaf-ten occopatioaal «ipo*ura.
icsTBii; aoiemi: GEBUIT; nmi;
ICI.1I!>: S5SJ11; SWHEt; UStllD
miss-, isiecse IISSUB; sj.coc: noofi
ttisnt; iiocc siftw: EiiriEocrns:
itmcocnss: IIIK; «*»i; atrz»:
BIllTJ BIZJBCS: OCCOF11IOUI IIIIKOS:
tcenmoi nnson; nonues:
IISTICI3IS; CBLOBIII OIE1IIC
CCSPOO«3

tzntnci

twlckaaaii, I.B.
KacsoftaUi ?•£•
1977
Ecototlcolo^T aal
rarlruaeatal Safety
1tS9**t 10

















Deichaano, I.B.
McBoaall, >.t.
1977
3c0tdxlcol&9y aa&
eorlraMantaJ Safety
1:89-1*0
















                                                               U)
                                                               OJ
                                                               o
-------
1.atS,«-OlMta.aBOU.pBtsalam«, 1,2,3.4,19, W-JiMacHoTO-«,7-«po»-jr1»*.»a.S,«,7,0,8»-octa«f«ro-,  ««do,ezo- ft cl)
2.7:a,$-DiMta.aaaaapata(2,3-b|oxlxeM. 3,aT5,6,9,*-besacU.9ro-U,2,2a,3,6.6a,7,7a-octahrara-.  
it ii i GEituL tnoiuTia* i (znmcs
1 1
1 1
I IfTiav I Deiciaann, ».B.
1 1 a»cDon»U, H.t.
I Eipos«a persons la tin OniteS states, ) 19T7
1 tl« I*tk«rl»4a, 5r«l«B, leraal, 1 Icotolieolojy and
t I>p*>( OSSB, Falmsi, (S«rnBT> I»ilia. t CnTlcaueital 5af«ty
1 toiler U, T«U«t>«, lartria. I 1:69-110
4 1
I E«port«d cu«a of kypcrteaaion, 1
I 4l«vat«d •«€«• cbol«kt4coj.c ab*4r*ftl t
1 lisa, or liptlrxit of n«oro»aacnl»r I
I (giction aft«c «cnt« •ipo«nre to 1
1 coitiutloia at p«stlcia«9, bat lost 1
1 iitt Stan 10 alT«rs* affects after 1
1 lem-t«n occupational «rposire, f
1 1
I losTRii: BULcuit; eraiui: ni>i>: I
i i si in.: Jm»; innmins; luistti; t
1 101 110 ; 1USSII! SnOH; QllttO \
t STUBS! ID t POS1 TISSOS: BT.OOB-. BLOOD I
1 FUSBl: nOOC StElI; SBTTBBOcnBS; I
1 itnocTiis; mit: mm: tmn; t
1 HUTU R11MBS; OCCOPJTIOIU RlZUItS: 1
I ECPtnitioi uposne i
i i
1 1
O 0.2 ppb « al Rural tiacla I rtoklm* J.
bl 9.2 ppb t t) Qtbaa ll»clts 1 Prtoater. l.i,
c) 0.3 ppb j c) Dcbn c**ca«lau 1 Cceason, J,f.
d) 0.* ppb t i) Kuial ca«eaalanm 1 Ra«Mt, T.
| 1 Kim«*. T.
1 ortam an! total r*ald«ats of sc, 1 laucc, D.t.
1 iifaats, chlKna, .Salts, «M«tlT. t 1972
1 1 li«rica> Journal of
1 SOOTB CKOlIll: AJOITS; CBIIDfiSI: 1 Public Health
1 I1CUI STV91ES: BIOOO PltEBl; 4 6201 = 615-451
1 CCimilTITZ ITllUTIOIS; DOI; PDE; 1
I cti: niBuilii PISTICICJS: i
1 KncHto»rmjo BI?H«IT.S: HI \
\ tCHBTtO»: TOOD COIIUIimoi; 1
1 tisiictot BisiDOES: nmiTion i
I tirosn*: (ITUL UEIS-. tie it istis t
«.) 0.031 p?i 1 *l »nt«l «»tb*r«, rat baelr 1 Foza Lota, R.
b) 0.010 ppa | t) Dtbaa aothats, tat ba«i« 1 Bercara lartaicha. 1.
O 0.020 ppa | c) 111 a«tb«t>, fat basis I Polo Tillar, I.I.
i) 0.0005 ppa 1 SI til aotb«r», (kola silt basis 1 Lopai-Sl»an«i, B.
1 tata lor na of all BMticiBtn aid I Jodcal Tlllar«jo, a.
I ccaparivoaa vltb »»l»s of otter I T<)l«$ias Petal, J.
1 iarcstl^atocs qiraa I 1)79
1 1 (arista Xapanola a«
I lacciaq aotb«ts fcoa CocJoba realm, t Milattia
1 S^aln 1 3S(2l>6l:*J*1tO
1 t
1 stm; utritsj friu: CHLOEIIZ OBSIITC i
l coepcons; ptsncijis; ISBICTLTTIEJ: i
1 tOBIL U!1S; OBB1» UB15 I
1 1
1 1
UI.2 * oc - a.3«.z | coapated on tat a41asteA basis t savaa*, I. P.
ppb | Fauna of a«au for all gaogiaphlc 1 X«efe, 1, i.
I c«qlais I tcsaaci, 3.0.
1 1 laealar, B.«.
1 Kcaln? aotfurs, IT. S.I. 1 Ipplebaaji, ».«.
I 1 Coos, I.*.
1 UIITID STiirs; IOOITS: ans: i rort, 5.1.
1 CCBP»1»IIH ITILVIIIOIS; CBLOBIC | 1941
1 cremc CD8IOOIDS; DISLDBII; | laerlcaa Joarnal of
1 ItSIICIDK; laCTmol I Epl4««lolo«r
1 1 1 W3 1«| i »U-»2J
t 1 1
Oin PIS!)
-------
    t.»:5,8-Di»etliaaoaap«t»alene. 1,2.3,4, 10>10-kexacU.aro-6,7-epoxr-1,B,Ba,S,«>7f8,am-octaavdra-, eodo,exo- fl CI>
    2.7:3.6-!)lMthanaaapktb.(2.3-b10xixeBe, 3,*,5,6,9. 9-hexaCBlora-1a.2,2a.3,C.ea,7,7a-ectaavara-.  (1nalpBa,2beta.2allpha.3beta.Sfceta,6aalpha,7beta.7aalpna)-  (9 CIJ

    C12-B9-C16-0
    !1 380.93, IIP 17«-177 C.  TV 7.7W10B-7} •• Bg at 20 C
                                                                                          (COITC(VED)
• Tisstn


4642
•ilk, tat














4643 |
Placenta I
1
t








IZPOSBIS BOOT!




























aflLTTIClL
RETBUU

OC-BC






'
1
f





SC-EC










nnsa
or cisss
















50










SHOE


a) lot given
b) lot given
c) tot given
d) Hot gives
e) lot given











1-6 ppb










nil i ecimi. XBFOBRtnoi
I
i
a) 0.086 * or - 0.063 I a) 1972, 40 saaples
ppa | b) 1973. 38 saaples
b) 0.99S * or - 0.072 1 c) 1971, 19 sanplas
ppa I d) 1975, 20 saaples
e) O.OSO * or - 0.040 I •) 197C, 19 saaples
ppa I f) 1977, 20 aaaplea
t) 0.062 * or - 0.021 1
PPB I 100-141 lactatlng VOKE, 2 aonths
e) 0.052 * or - 0.025 1 after delivery- Besidents of Osaka
ppn 1 Erefectare, Japan, Taxied diets and
1 ctTironnantal coclitions.
t
t EISTICIOES; DHIDSII: CBG1IIC
1 CBICBIW! COBPODiaS; Ja»l; UOIIS;
1 tlCTlTIOI: BIIK; BtOlCCDBIIUIOl;
1 EOITCHLOBIB1TED EIPBEITLS
1
3.93 ppb I 2 positive speciBeas
seosetric F
1 (xegaaBt «OB«B, linllat in
t aocioecoaoaie level and dietary
1 habits. Bo occapatioaal or
1 tcciflental eiposare. Lacknon, InJia
1
1 PIStlCIDZS: CBLOCIIinO E1DBOCIRBOJS;
I CEIOBIXB oseinc coapovras; HDD; DDE;
1 DDI; IIBIl: PSICUJCI; 1BBIOIIC
1 IIOID: PllCIITa
i
SEFEUBCE


Takashlji, T.
ratanabe, I.

Tosnida, S.

KnnitaJ «.
19T9
International archives
of Occupational and
Xnviioaaeatal Health
03:1-15





Saxena, B.C.
Sett. T.D.
Baha-laa, P.I.
1980
International Journal
of inviromental
Analytical cheaistry
7s24S-251



I
                                                                                                                                                                                             u>
                                                                                                                                                                                             NJ
2-B«t«BOl,  3-mottrl-
S98-75-*
C?-H12-0
If 8S.1S.    128 C
1 TISSUE
«CM
Breata


I
1
1






1
1
EIPOSORS iom

1
1
1







r
i
i
1H1TTIC11
HRB09
GC-BS













g»BR
or cists
54 (387
staples)













1 BUGS
lot given













9EU
0.378 ng/1
Seoietric













GIIIM1 IVFORBITIOI
Beaaoxed at 2S C and 760 mm Eg
15. 5f occurrence
Io>«c and upper one-Siqna Units
0.123 and t.16 ag/1

Bialtbv, 11-35 TX old, noBSBoklnq,
nrtan blacks and cancasians.
CaieBgo, II. Pioidly controlled
ciperiaeatal coadltioas.
f«UT8: iicoiots; HI.IJOIS: IDOITS;
CP.LCBIUTZD BTDBOCtlBOIS; TOUTILE
CteillC COIFCUIBS; 8I11TB BIHSCS:
I'RIUTIOli SSTAEOLISI; BETaBOIITISi
tcfouTioii riposai:; IBB lit JEHS

misstcs
Kcotoszynski, 3. 1C.
Brnnean, 6. If.
C'Keill, H.J.
1979
Jonrnal of analytical
Toxicology 3:225-231









-------
2-Jataaone
78-»3-3
C4-B8-O
If 160.27. BP 74.57 C. TO 71.2 H Iq «t  20 C
tlSsOS

•««s
Breatk










4646
Breath












EIPOSOBS BOOTS



























1IUTTICIL
nrrHOD
8C/BS











SC-BS













•naiss
or cisis
8











54 (387
sasples)












Mies

lot det«ct«d-60.0 agykr








•


lot 9ir«n













nil

1«.« ag/kr











3.6 ag/1
Geosetric












6ZBZUL iiroBHTioi

ccaiomd related to norul
ictabollaa. lo other detalla gives
Cryoqeaic saapliig teekaiqiM.

Dcaltkr a Hilary and clTlliao
«iFlOT««s. U.S. Hi Forc« School of
Mz«spac« a«Jlciii«. aqes 23-»7 yr. 3
stokers.
imnis: CBICIIIKBI BIDBOCIBBOIS;
cnoilK oseuic coatonns:
CHioBOBiiiiwis: nnoiiis COHJOOMS;
IIHTB: HCOBOLS; THIS; 1 DOITS
Iiasnrei at 25 C ud 760 •• Si
53.2* occvrrcmce
Icier aad spper one-siqaa Halts 1.48
and (.8 aq/1

KcaltkY. 18-35 jt old, aoaiaokinq.
actaa blacks aad caacaaiaaa.
Cblcaqo. 11. XiqidlT coBtiollcd
eipcriMatal conditloaa.
»(UB: IICCBOIS! ILIIIOIS; 19QITS;
CEICBIBKZB FIDSOC1BBOIS; T011THE
ctsanc coBtooios; aztua BIUBDS:
HBaUTiev: aniBouss; BIHBOIITES;
tcfoiKioB inosm: IBBIB utis
SETCBIBCI

conkle, J.P.
Caip, B.J.
Selch, B.E.
197S
arckiTas of
Znviroaaaatal Health
30 (2) : 290-295





KiotosTTH«kif B.K.
Brvneaa* 6. 8.
O'Helll, B.J.
1979
Journal o£ inaljtlcal
Toiicoloql 3: 225-234








                                                                                                                                                                                              U)
  2-Bataaoae.  3,3-diaetkyl-
  75-»7-8
  C6-B12-0
  •I 100.16,  » -«».8 C, BP  106 C at 760  aa   18-35 TC old, sonaaoklng.
otliB blacks aad caocasiana.
Chiciqo, TL. Blgldlr controlled
eipcrlseatal coadltloas.
HIITI; 11COBOLS; IUIIOIS; JDTJITS;
CllOBTIaTtl ETOBOCHBOIS: fOltTILB
CS«»TC COIFCOIDS; BB1LTB BaZUDS;
iiamTic": lETteoLisH: sziiBotms:
EOfOUTIOf IXPOSQIE; H1B1B UBtS
BtrEBIBCE |
1
1
Ktotoszyaski., B.K.
Braaean, G.H.
O'Helll, H.J.
1979
Journal of analytical
Toxicology 3:225-234








-------
    	 IH-
    &!«-«»-«
    c»-ie
    Bf W.12, I? -105.55 C,  BP O.S8 C.  Tf  1M2  u
                                                    «t 21 C
tlSSIf.
««(t
Breath









EltOSTOJ BOOJE











HlIttlClL
BITHOB
ec/ss










IDWS8
or CASES
t










111SE
lot d*teeted-»0.0 »9/«r










Bill
10. S toyhr










GIBtlal imrOtBtTIOI
Ccifonid relate.1 to mraal
•etaooli*!. lo other ieti.ll: aitn
Crjoaeaic saaplXaa technique.

Realthr lllitary «ed eiTlllaa
eiploreea, tt.S. Ur force School at
lermptc* Betticiae, a«es 21-47 jr. 3
»ok«r*.
ItltntS; CBIOUHTED mtOCUlCIS;
cfltosiiB cieinc cospomiDS:
tiKJtosEtztwzs: riaotiix costoatass
mattes
Coakle, 3.1.
Caep, B.J.
Velch. B.E.
W75
Ireaivea of
foTironBCBtal Health
38 (2J *2*0-295
•



   2-Bit«ae.  til-
   5»0-1»-1
   C«-B»
   II SC.12, IIP -1M.I1 C, EP 3.7 C, TP 1»10 u Bq at 21 C
Tissue
*«*•
Br«ati


1







ItNSVH BOITB












1 IIUTTICU
mtoa
ocyss











•tJBBIB
OT C»S!S
a











t»ei
lot d»tect«d-23.0 «4/hr











Bill
4.8 09/hr











GUtBll IHOSI1TIOI
Cciroiid telat*! to Mtul
Mttholtsi. lo other details given
crroouic nmtl±ag teekaioie.

leiltaT •ilitarr and oliilian
eeplojees, U.S. lit force School of
lerospace iredicia«. «3« Z3->7 rr. 3
stokers*
llltniS; CBICEI»«EB BTDSOCtBSOilS:
cEioBtiB otetnc conotmst
ciiotoiiizivES: renoaiR ccnro0»!>s:
t1Z»l; tlCCfiOU; THIS; UDITS
tmsttct
Comtle, J.I.
Ca«p, B.J.
leleh. B.I.
197S
>CCbiT«> Of
Inriioaratal Health
30 (2)! IJO-295





                                                                                                                                                                                          OJ
                                                                                                                                                                                          u>
2-Etarl-l-P«>t«eoI
C7-BM-0
Bl 114.23, BP 16»-16t C
                       postings IB CBWUTIE).
( TIS5V1
1
1
1
1 treat h
1











I BirOSDJ! IOOTI
1
1













' "SCToJ"
i
1
ac-iis












IOBI3B
or cisis


S» f387
niples)











	
1I1GE


lot ?iT«*












'EH GBIIBI1 IlrOIHTIOB


0. 27i 09/1 Btained at 25 C and 760 la Bif
eeoaetric | 3<.9t occurrence
1 lover ud epper ooe-slga. Halts
1 0.14* tad 9.729 09/1
1
1 lealthT. 18-35 ?r old, nomaoXtnq,
1 vrtan blacka and cavcaaiaia.
t Cbicaga. TI. Blgldlr coitrolled
1 tip«riieat*l cotlltloti.
1 tlllTT; UCQCOIS: IlLIHOlSi IOOLTS:
1 CflCBISHEB BTDSOC1BE01S; VO11TI1E
( CECaflC COBPCCUDS: BU1TB BltlRCS;
1 IWUlTIOIt BCTaBOLISS: BBIlSOlITSSj
I »CPOI»TIO« BlfOSOlB; IJB3H 1BEAS
1
EEfEBEIC!


KrotosTTBali. 9.1.
Bmneaa, G.R.
C'leill, B.J.
1979
Jourul of loalrtical
ToilCOloqT 1:225-23*









-------
2-MraiM
!»2-»3-s
I* 8».16. IP t«1.3S C.  BP 68.5 C
TISSB!
»651
Breath










tXfOSOBZ BOOK












luinicai
1ET8CO
OC/HS











•mass
or cists
8











MKZ
lot detected- 17.0 ug/kc











«a»
«.0 ag/hr











GBIIUL xiroMitiov
ccafoatd ranted to aona.1
MUbellM. lo other detail* giwa
Cryogenic ailpllao: tackliqo*.

B«ltkf illltiCT u4 cifillaB
(•plains, o.s. itr Torco school of
ictaaiwec H«4icU«, «qes 23-»7 yt- 3
stokers.
tllZHES; CBtOEIIlTJII HTDXOCUBOMS:
CBIOMIB OI61IIC C08PODIBS;
cmcionitziis; rtnoBUE COBPOIIDS:
II1HI; ItCCBOtS; TSIU: UDITS
- 	
taisact
Conlcle, J.P.
Ca«p, B.J.
Belck, B.t.
1975
IrchiT** of
IiTicoBMital Health
30 |2) : 290-295





 2-Octaool
 C8-B1S-0
 BI 139.2, "P -31.6 C, BP 178.5 C,  TP 1  •• Kg at 32.8 C
I 5ISS1!
1
«C52
Breath









•«53
Breath












IlfOSOM BOWS


























inimciL
"r™o»
«/BS










SC-BS













BWBHI
or CISES
8










S» (387
staples)












B1«GJ

lot detected-98.t uq/tr










lot given













mi

12.3 ug/hc










O.M ng/1
Geoeetric












etnui nreiunoi

Ccifoigi related to Docaal
netabolise. lo other details given
Cryogenic stapling technique.

Maltiy ailltary aad ciTllian
eaployeea, B.s. »lr force School of
lerospaee Bedlcine, ages 23-47 yr. 3
IIHEISS; CBlOBlniTBD HTPBOCiBBOBS:
CELOBIHB OBfiUlC C01POUBPS;
cnoBoanzztu; rLiOBiis COBTOVIDS;
HIITB: 11CCBOLS; THIS; 1DD1TS
(ensured at 25 C and 760 an Bg
31. 31 occnmice
toner and of per one-siaaa liaita 0.26
and 3.1 Bq/1

lealthy, 18-35 yc old. noaasokieg.
nrfcan blaclcs and caticasiana*
Chicago. II. Blqilly cant tolled
eiptrieestal conditions.
IB.EITB: I1CCBOIS: IUI10IS; IDdttS;
CBLOSIHTIE BTDBOC1B30BS; TOUTILE
CIJIWIC COBtCOIDS; BltlTB B1Z1BD5;
11BIUTICI: BETltOLtSS; aETlSOLITBS:
fCPOLiTiot ZIPOSUBB: DBBIB iitis
tmntct

Coakle. J.P.
Caap, B.J.
telch. B.».
1975
Itchlves of
ZnTlronneatal Health
30 (2): 290-295





Ironean, G.M.
O'Helll, B.J.
1979
journal of analytical
Toxicology 3:225-23*








-------
     2-Peattaoae, a-mtkyl
     108-10-1
     C6-B12-0
     B« 100.2. HP -S».T C. IP 116.85 C. TP 16 ee
1ISSVB

•S5»
Breath










txtosms torn*













iBunxcii
BETSOB

ec/HS











BIB an
OF CaSES

a











BlBGB

Bot detected-2*. 0 ag/g











IE1B 1 email. IBPOBB1TIOB
1
I
1
».2 ag/hr i ceapaaad related to aoiaal
1 tetabolisa. (o other detail* ?iiea
j Cryogeaic aaapliag techaigae.
I
1 Bealtk) ailitary aad cUiliai
I eaployees, U.S. air Force school of
I lereapace BediciBe. ages 23-«T jr. 3
t fiokecs.
1
| tlBtini; CBIOBIIHEB BIOBOCUBOBS:
( cno*in orsiBic coitoans;
| CBtOBOtEBZIBfS: flOOBIBE CORPOITBOS:
t tBIlTI: 11COBOLS: TZI15: ID01TS
SEFEBnCZ

conkle, J.P.
cup, t.a.
ire lea. 9.E.
1975
ircni»« of
ZBTinvaeatal Health
30(2|t290-295






    2
-------
2,2-Oia«thrlactaBol  (to
2310-14-1
C10-I22-0
11 158.29
                                 t> caiman .
nssn
*«S7
>t*atk










moson toon












alaimcu
RETBOD
ec-as











ioun
or casts
5* (3*7
staples)










1MG1
lot 9l**B











asu
0.317 ng/1
MOM trie










cuttii iiroiunoi
laatsni at 25 C aad 76« la Sg
31.0* oceariaac*
IOB«T aad appar oaa-Slou lislta
0.109 aad 0.915 *oyl

ttaltBT. 18-35 TT old. BOBaaokiaa;.
ittai Macks aad caacasiaas.
Cklcaga. II. Flqldlr coatcoll«d
«xp«rla«atal oaadltioaa.
mm; >icoioisj HUMUS; IDIHS:
CU.CIIIIT1D BTDBOCIIBOIS; TOIITH.!
CIBHIC COBPCT1D3! BBILTH BillBtS:
IlBiUtlO*: BMISOHS!; HgT>9OlITlS;
ICVOUTIOI IINSOH: OBB»» ISEIS
-
Krotasxiaakl, B.X.
Bnneaa. a. I.
C'Mill, B.J.

Journal o{ taalftlcal
Tozleoloaf 3:225-23*






 I.2,3,3-letr»»»tiTlh«i»ii« (lo postings IB CBCTUI1].
 13«7S-81-5
 CW-K2
 81 1*2.32. B> 1«0.3 C
TISSUE
Bnatk











EIPOSOBI POOTI












llllTTICIL
RETROD
GC-KS











tnasis
or osxs
5* (387
aaaplcs)











MI6>
lot giT«n











Btil |
1.3 aq/1
GeoMtrie











GBIIHL IITOMITIOI
e«a»t«4 at 25 c aid 7CO at Bq
lenc au4 appac oac-Si^aa Halts 0.35
aad *. 8 «q/l

KilttT, 18-35 TT old. BoaaaokiBq.
aztaa blacks aad ca>ca*iaaa.
Cklcaqo. 11. BiqidlT coatzoll*!
BBHTB: aicciois; nmois; IDOIIS:
CIlOBTlaTn BIDSOCltBOIS; TOUTIlg
Cf3i«ic coiicnns: SIII.TB BIIMBS;
HIlttTKl; F.3T1BOIIS9; BETaBOlCTIS;
EOPDUTIOH tIPOSOIX; T>SB11 UEaS
nFZlNCI
KiatoaxiasU. B.I.
o'i«ill! aljl
1979
Joataal of aaalrtical
•torloolo^i 3:225-23*







                                                                                                                                                                                             U)
                                                                                                                                                                                             --J
  2,3,3-TriaBthTla«xaa«  (lo postiags in CBZflLIfEl.
  C9-B2-O
  t»  12«.2!. It  137.7 C. TP 10.1  aa H«j at  25 c
1ISSOE
MW
Sratk











EIPOS9BE BOOT!













nurricn
BETHO9
6C-SS












lOMSt
or cisxs
5* (387
saaplas)











nisi
lot giT«a












Sill
0.730 ng/1
Seoaetcic











6IIIBU IiroiHHIOl
e«aaar«4 at 25 c aad 760 aa tq
18.*' occarr»e«
£c«*c aad upper ona-Sloaa Halts
C.U7 aad 3.62 aa/1

Kalthr. 18-35 yr old, nonswikiaqj
aitaB blacks and caacasiaas.
Ckicaqo. Tl. ItqldlT cant colled
ciB«rlB*Btal eoaditioas.
BiiiiB: iiccBois; miiois: inoits:
cncnitTZD ETDROCltBOlSj tOUtllB
CE61ITC COBtCtTIOS: BEIHB BIHSOS;
IIB1UT1CI; alTlEOLISS; BElaBOtltZS;
BZ7EIEHCE
KOtOBllUBki. B.K.
Bcnaaa, S.I.
O'letll. B.J.
1979
Joaraal of aaalrtical
Toiicoloqr 3:225-23*







-------
     2.3.3.*-T«traaetarlpeitaae  {*> postiaas la erasure).
     167*7—38—9
     C«-B2-O
     (1  128.25.  BP -102.123 C, IV 1*1.551 C
fisstrs
»6SO
Breath












Eiposvss aooit














IHttTICII.
BBJBCD
ec-B5













BOBBSB
or cjsu
5» (387
•aa pics)












MK>
lOt ?ina












1
III!
0.39* «9/l
Geoaetric












ezizsiL nroBUtioi
E*a«nr*4 »t 25 C aa« 7«0 « Bg
10.»* ocetrreac*
Imer and opper oae-Sl«aa liaits
0.113 ana 1.41 ao/1

Kattlif, l»-35 rr «1*. oou«o)ti»9.
acfc*i blacks aad caicasianfl.
Ckicago, II. SlgiSlT controlled
ar«a at 25 C *n4 7*0 aa H<)
«. It occarreaca
lowr and upper one-sigaa Halts
0.020 sad 0.712 aiHiTic>: RRIBOUSB; BIKEOITTISJ
tCPtn»TIO» -IPOSBBE; DBB1B UtlS
1
BlfMMCI
Krotosx^aakij B.K.
Bruneao, e.g.
O'Veill. S.J.
197t
Journal of analytical
loJicolegy 3:225-23*







1
	 1
                                                                                                                                                                                        U)
                                                                                                                                                                                        U)
                                                                                                                                                                                        CO
3-Heptanow, 5-aetarl-
5*1-85-5
CS-B16-0
F> 128.22, BP 160.5 C, TP 2.0 •• Bg at 25 C
1ISSOB
•«62
Breata












nvosm! BOOTS














mi men
BETIOD
OC-BS













ITB9BIS
OF CUES
5* (387
Maples)












I»E>
Bot firen













BB1B
0. SOS BO/1
seoaetric












GTiiEiL ziroaaiTiov
-
leaaared at 25 C and ISO aa Hq
5.27 occvzrence
lo»«r aad upper one-Slqaa liaits
0.200 aal 1.27 IKJ/1

Bt«lthT, 19-35 yt o!4, aoasaoklav.
ittan blacks and caacasitns.
Chlcaqo, II. sioUlr COB trolled
eiperiaeatal coaditlona.
mm; ucctois; ituiois; IDOITS:
CEICBIWIT'D BTDBOC1BBOIS: 10HTHS
ClGllIC COttCOtDS: BEtLTl BitlBtS:
UBIHTIOH; (mkEOLISB; BIT1EOLITSS:
icponnoif EiposaBi: 
-------
3-Bexanona. 2,«-diaethTl-
i86»i-7o-e
CS-H1S-0
RI 128.21. !F 1(5 C
TlSSm
•663
Breath












ZKtOSdBZ E001I













ilaLTTICal
aiTBOD
SC-HS












IOBBIS
or cisss
5« J3B7
staples)












BaISS
lot giTen












BUI
_
0.311 ng/1
seonetric












61)1111 IirOBBlTIOJ
Eeasnred at 25 c and 760 ia He
25. 3% occurrence
l««er and npper one-Siqaa liiits
0.134 and 0.«9» noyl

BaaltkT. 18-35 -r ol4, nonsaokinq.
art an blacks in a Caucasians.
Chlcaqo, II. ElqWlT cOBtlollad
«pcrii«>tal coadltioaa.
EiUTH; 1ICOCO1S; IU.HOIS: ICO ITS;
cnoBintiD noiocasmis; SOUTHS
C»OJ»IC COBPCOSDS: 9SJITB H12»SES;
IIIaLHIOl; inaEOllSH; BITJBOIITSS ;
tCrOLtTIOl IIP030IB: 3BBi» 12B1S
Bimnci
Irotosijuslti, B.K.
Braneaa, C*8.
C'Mill. I.J.
1979
Journal of analytical
Toxicoloql 31 225-23*








 52B-97-2
 C€-B12-0
 H« 100.16. BP 1SS-15T C
TISSUE
•66 1
Snath












MPOSUJ! M)BT»













tSILTTICll |
BBTBOt |
1
SC-IIS












iBBBta i
or cisss t
S« {387
saaples)











1
BUGS |
1
lot given












Bill
1.1 »g/l
Geometric












SIIEBaL moiliTIOII |
1
1
t«as*r>a at 25 C a»d 7*0 ai Bg
Ifi. 3T occurrence
loner a»a offer oie-Sigaa liiits 0.28
aid 4.3 no/1

Bcaltay. 18-35 Tr old. noosaokinq.
oTtu blacks ana caocaalaoa.
Ckicaao. It. Biqidlr contcolled
€ipccia«iital conditions.
ESt«TH; alCCBOlS; IUIIOI5; tDOITS:
CBIOBIU1ID BTBBOC1BBOBS; »011TI1B
CBCtlltC COBPCOSB5: BEaLTH B1I13CS:
1IH1HTI01; IWTIBOLISB; KSTIBOLITES;
EC?aHIIQ« IITCSOIE; OBBH IBEIS
5ETI8EBCE
Krotosmskt, B.K.
Eraneaa. G.«.
C'Seill, H.J.
«79
Journal of tnal^tlcal
TOilcoloqy 3:225*23*








 3-PentaBoae,  2-«ethrl-
 C«-B12-0
 B»  100.16.  BP 1K.S-115 C
itsso-

a66-i
Breath











zirasma scan














allLTTICal
BITBOB
SC-BS












IVB9EB
Or CaSSS
5« (387
saaples)











BUGS

lot given












isTi j

0.86 ng/1
3e one trie











GElIBal XITOStaTIOl

leasgrel at 25 c and 760 aa Bq
31.3V occurrence
lever and upper one-Si gaa liiits
C.023 and 0.33 nq/1

Bealthr. 18-35 yr old. no»nokinq.
artan blacks and caacasians.
Ckicaqo. II. Siqiair conttolled
eiperine-tal conditions.
fUMTH; itCCBOlS; IHHOIS; 191I.TS;
CELOBIWHTED CTDBOCfcBBOBS; TOX&TXIE
CtGlKC COIfCnDS: BlllTH BltARDS;
I«B»HTIC«; HE/tatoLis^: SEHEOLITIS;
tCfOLlTIO* IIMSOttE; H9B1J IBEtS
BETEBEBCE

K 0
Crimean. G.g.
C'Heill, B, J.
1979
Journal of analytical
Toxicology 3:225-23*







-------
    1M7-20-S
    C9-B20
    •* 128.25. HP -33.11 C, (P 1*6.17 C
iissni
•««
Braatk











nrosmtE IOBTB













iiumcu
sc-ss












or C1S2S
5* (317
aa>fltaM do posting* la CBgnni).
   422-W-1
   C»-B2-0
   II  US. 25, II  1»0.« C
Ttsm
«««7
Snatk




1








titoimt scant















H11TTTCI1
nsrnoD
OC-gJ














imm
OF cms
M (3*7
saaplca)













IMCI
lot 9! van














BUI
2.J »a/l
6«OB«tric













e:iicii iiroiuiioi
E«amr«d at i5 C a»4 7 SO •• B«
27* 7t occvmnc*
ICTHK ac< opp*r oav-slgw lldts 0.98
• tt 5.* *4/l

Maltlir* 11-35 rr old, BoxaioktiKi.
mt» blacks and eaoea»la».
Ctleaqo. II. tliltlr contcoll*4
«ip*rlnotal conditions.
etziTB; itccms: iirnois: »ous;
CnatHHID ETDlOCtlBOIS; IOI1THS
cieiiic cospou»ns: SSIITH BIHBDS;
IlltUTIOf; RRtEOlISX; «!1EO1ITKS;
iopnt»no» ixrosmR: »>» IBIIS
i
BEmncz i
!
Kcotoaxj-nati, S.S.
Brao«ao, C.I.
O'latll, S.J.
1»79
Janrinl of Inalytical
Toilcoloqr 3:225-23*









                                                                                                                                                                                            U)
                                                                                                                                                                                            *-
                                                                                                                                                                                            o
4-MptaaoM
123-W-3
C7-BU-O
BW 11*. 1*. Bt -32.6 C, It 1M C
nssn
»«€8
Braatfc












sifosffBS soon














inirticit
BITSOB
GC-BS













Boaia
OF CJSJS
5* (387
saaplM)












SHIS
Bat giT«a












-
1 B3H
1
0.07* BJ/1
Je Metric












cEiiBtt mossinoi
B«aaar*4 caaeasiaaa.
taica«o, 11. >io.lily conttollal
«tp
-------
t-leptaaone
123-14-3
Cl-iW-O
Bl 11». 18. UP -32.6 C, BP 1« C
                                                                                     (CORIIVBD)
ITS SOB
»«»
VClM






nposm BonE
Serial






lIUITICtL
BROOD
OC






or CUBS
a» IS
b> «o






BIKE
4) 0.01-1.5 sg/g
CreatinlM
b) 1.5-3.7 sj/g
creatlBiaa




_.
am
a) lot gives
b| lot glres






Gil till XIFOIBMIOI
'
•) Costrola
b) forkers eiposed to chloropheaols
Inkers lit h«rblcll« laaufaetirlna
(lint*.
BfSBICTDBS; HBOSTMU M.1JTS;
cccaptTioiu Btzugs; rssriciDis:
icmuTiof Bitosoii: CBLOIIBI OBGIIIC
ccBPovns: IBKOU: cmoi: mm
BZnBBlCB
T«B Boeotian, P.B.
n«Ln, i.i.
1980
International ireUvu
of Ocnpatiaoal and
EiTironaeatal Health
•5:57-62


C12-H1*-*}
It  186, HP  300 C

•«TO
Blool,
plaan








MTHOO




or cisss
1


-
BIIGE
•ot glTea



BEaB
0.133 »g/l



CEB1I11 IBTOIRITIOR 	 j
C Aayi after 50 •! dilited grancoiie
39 jt «ia, aildto atteipt.
El»p«««, r«nl f allot*. fallUq
forces Tital capacity.
Imeitel urea, eteatliiie.
Etotelanrla, hrallie east* IB itlie,
(eiiUlar ofaeities.
aziBICTDES; tBSTICIDBS; BLOOD PtlS'Tl:
S1ICTDI
	 	 	 	 	 	
*S*BBBICB
Eose, J.D.B.
1990
Lancet 2(1200) :92*



                                                                                                                                                                                        OJ
a.T-Bethanolndan.  1,2.»,5,6,7,».8-octachloro-1.2-ep«T-3«.«,7,7a-tetr«tiYdro- (( CD
2,S-!)eth»o-2B-iBdeso(1,2-b)oxirese,  1a.2,3.s,S.Ca.7,7-oct«cUazo-1a.1b.S.5a,«,«a-t
 26880— a8— 8
                                                                                             It
    m.n

•671
111k














BETBCn
GC






OF ClSSS
	
1««





_____
ins:
75.4-11S.3 ppb





. 	 	
8E1I
95.8 * or - 195.1 ppb






GE«tB*L HTOB9ITIOI "
Ccipited OB fat aallit«J basis
lanoe ot Maaa for all geoqiapkie
< agios*

cinio siHisj minis; mi;
ceiptBuiTE mmriois; caioain
CfSHIC COBPCITIDS; HSIDBII;
VISTICIOBS; tlCTanOI



IERBETCE
"
Sarage, E.P.
Eeefe, T.J.
Tessarl, J.D.
•heeler, a.«.
applekaaa. T.E.
Goefl, E.I.
ford, s.i.
1981
laerlcan Joarnal at
Ipilesiolog}
133 («) :«13-«22
-------
a.7-!!etlianoina'an. 1,a,5,C,7.8. 8-heptachloro-2,3-epoxT-3a.a,7.7a-tetrahvdro- (8 CI)
2,5-8«thano-2H-iideiio(1,2-b)oxireie, 2.3.B,5.«,7,7-heptaehlora-1a,1b,5,5a.6,6a-hexahvdro- (9 CI)
1024-57-3
C10-BS-C17-0
II 389.32

TISSUE
4S72
Adipose
1673
Adipose
1
1
1
1
4674
Hi Ik
1
1
1
•675
111k
ETPOSOBE BOO!


Ingestton

AIUTTICAX,
HETBOD

GC
GC
GC
BOBB5B | BABGE
0? CASES |
1
1
1
1
1
1
1
1
1
1
f
1
1
1
1
1
1
1
1
1
1
1
1
60 | <0. 05-11.? 5 pp.
1
1
1
1
1
1
21 I » 0-0.296 ppl
24 1 b) 0-1.902 ppl
15 | c) 0-1.002 ppl
45 I d) Mot given
1
1
1
1
1
1
1
1
1
1
1
6 | 66.1-128 PPB
1
1
1
1
1
1
SB»» | GIBIBAt IITOSBATIOB 1 EEFEBIHC!
1 1
1 I
1 1
I Scviev f Deichaann* V.8*
I | McDonald. I.E.
1 Expose! persons IB the United states. I 1977
1 the Netherlands, Sweden, Israel, | Ecotoxicologv and
1 Japan, BSSB. Polaad, Geriany, India, 1 Environaental Safety
1 Enlgaria, Pakistan, Austria. 1 1:89-110
1 1
1 deported cases of hypertension, 1
I elevated serai cholesterol, abnanal I
1 EIGs, or iapairaent of nenrcnscular 1
1 fnctioB after acate exposure to 1
I calcinations of pesticides, but lost I
1 Icng-terB occupational exposare. j
1 1
1 lOSTBit; BOLGABIA; GEBBAii; noil: i
I ISB1EL; JAPAl; HETBESIAIDS: PAKISTAI; 1
1 tcLiio: BOSSII: SIEDEI; DIIIED i
I si »i is: IDIFCSE nssijJ: BLOOD: BLOOD I
| FIlSBl; BIOCC SEflOB; EBTTHBOCTTES; I
| IIDKOCTTES; BILK; OBIXZ; BETI5W; I
| BI11TH B1Z1IDS; OCCtlPlTIOIU B1ZUD5: 1
| FCPOUTIOM BIPOSU3E; HIOPLJSBS; |
| FESIICI3IS; CBIOBIIE OEG1IIC 1
| CCBPOUUDS |
1 1
I 1
0.38 ppa f Peripheral kidney fat, routine 1 Oejonckheere, ff.
I cathological exaaiaations I Stearbant, 9,
I 1 Terstraetea. E.
I Iqes 6 ao-92 yr. Belqiua 1 Kips, F.H.
| | 1978
1 EiiGloi; BIOPSIES: IDIPOSE TISSUE: | Toiicological European
I eio*CCOnniTIOB: PISIICIDIS; DVD; 1 Research 2(21:93-98
| ttl: DDT; DlttDBIl: BEPTtCBLOR I
| ffOHDt: BtXlCtlloniSEIZEIl: LI (DIKE; |
| CELORUB OBG1HC COflPOaiDS \
1 ' ^
1 1
0.017 ppa I a) Baral anthers, fat basis 1 Pozo Lora, B.
0.051 ppi j c) urban Bothers, fat basis I Herrera Barteacbe, ».
0.035 pps | c) 111 Bothers, fat basis I Polo Tillar. L.n.
0.0003 PPB 1 d) 111 Bothers, nhole ailk basis 1 topez-Giienez, I.
| Cata for son of all pesticides and 1 Jodral Tillarejo, 
                                                                                                                                                                                          l-o
-------
«,T-Bettanoindene,  1,t.5.6,7,8.8-heptacliloro-3a.»,7,7a-tetraoTdro-  (8 CI)
                        I.I.S.S.T.a.S-beiptachlaro-aa.a.T^a-tetraliTaro-  (9
«t 373.35, Ht 95-96 c,  Tf 3TIO («-») H  Bq «t 25 C
Tissue
«67«
"ilk











ZXtOSTOE B001! 1
tngestion












a>U.tTICU
MTtBOB
GE












R09B3B
OF C1SES

b) 2»
0 «5
d) «5









IMS!
a) 0.405-10.823 ppa
b) 0.615-11.686 pps
c) 0.1105-11.686 pps
d] lot given










a) 2.556 ppa
b) 2.«62 pps
cl 2.505 pps
d} 0.0390 ppn









GtltElL IlrOSIlTIOl
-
a) Bural lathers, fat basis
b) Urban Betters, fat basis
c) 111 eotaers, fat basis
d) 111 eotaers, vnole ailk basis
Data for svn of all pesticides and
^caparisons vlth valoes of other
investigators given

•ntslnq notnecs froa Cordoba region.
Sraia
SFllI: IBDtTSj BILK; CSLOBIH OieiflC
CORTOraDS; EISTICntS; KSBICUtTTOI:
CIIU 11I1S: OBBII tBElS
BEfEIEICE
Pozo Lora, B.
Becrera Earteache, a.
Polo Tlllar. L.9.
Lopez— Ginenex, ••
Jodral Tillarejo, S.
Tglesias Perez, J.
1919
Sevlsta Espanola de
fedlatria
35 (206): 93- 110



 5-»ortora«»«~2.3-4l»ethanol. 1. »,5, S.l.-T-heiictiloTo-. cyclic s«ltlt« (8 Cl>
 «,9-Ktbana-2,K.3*be«zoa.lai*tiii«paii, 6.7,«,!.1l),ia-»eiicla»ro-1,5,5a,«,9,51-terahiiro-, 3-0tide \9 CI)
 II5-W-7
 C9-B6-C16-03-S
 •• •06.*').  flt  106 C,  n 1I10CI-5)  as Bq at 25 C
Tissni |
1
vhole

EXPO&llfiS RODTB


mtmciL i
IHTHOD |
GC-EC

or CISES
a) 35
b) 12
0 36
d| 12

1U6E
a) lot detected
b) lot detected
c) lot detected
1) tat detected

nil
a) lot detected
b) lot detected
d lot detected
d) »ot detected

C.IIEUL IIIOSBITICI
a) Tniodan I, Love canal residents
bl Taiodan I. volatteers
c) Ihiodan II, Ion canal residents
i) Tbiodan II, vol«ateers
lisit of leasnreaekt, 0.23 n<)/q for
•thlodan I and 0.32 aq/q for ThioSin
II
CloaelT aatcbed, slanltaneoai control
ta spies *ere aot provided for
aaelrsla alooe witk those froa tie 36
lacklmq neaninqfsl control or
literature data relative to the
significance of the lo* residues
fcnnd in the field saaples analvud,
DC definite conclusions can be dram
fees the results reported.
lesiieats of tew Toil. Controls,
eiplovees of the laviranuital
Erotection Iqencr a«d university
itid«9t8. fcrth Carolina.
Ill T01K: tcm cuoilll; WOOD;
Bi»aenm BROODS; CHICHIE oiGinc
CGBEOanS; CtLOBOSElIUM;
cipmns; roeounoi EIPOSIH
EIIIBESCI
Bristol. 0.».
19BO
II1-«00/1-80-036, ao
pp.
1
                                                                                                                                                                                             OJ
-------
  345
DRUGS
-------
 (1, 1*-3iphenTlJ -m-bntanoic acid, gasea-oxo-
 3H30-85-5
C16-BU-03
RR 25*.3, at approx 180 C
TISSUE
•678
Blood,
sen*
















Urine


















	 -
EXPOSURE SOOTE
Ingest ion
















Ingestion,



















1 Hit men L
HETHOD
HM.C
















HPLC



















HOBBSB
OF CtSSS
26
















26


















-.
B1RGE
a) Rot giT
b) Rot giT
c) Hot giT
J) Rot giT
e) lot giT
f) Rot giT








'







a) lot giTen
b) lot giTen
c) Rot giTen
d) Rot giTen
e) Hot giTen
f) Rot giTen


















1 R!ll
1
«) 13.7 * or - 5.3
b) 8.2 * or - 7.9
ag/nl
c) 80.1 * or - 13.2
ug/nl
d) »5.8 » or - 22.5
e) 0.7 t or - 0.3
ag/nl
?) ».2 » or - 2. 1
ug/nl













a) 1.9 » or - 5.8 ag
b) 1.6 » or - 3.6 «g
c) 1.8 » or - 2.0 ig
J) 7.1 « or - 16.8 17
e) 13a. 6 » or - 61.7
f) 5«. 1 + or - «9.7


















Gzimi iiposiiTioR
a) Rornals (creatiniae clearance >80
il/min). measured as unchanged
fenbafem
t) Benallr Impaired (creatinine
clearance 3-20 ml/min) , measured as
fenbufen
c) Roruls, seasnred as
gaiia-hydroiyt 1. 1'-biphenyl]-l-butano
ic aciJ (metabolite II)
d) BenallT impaired, measured as
metabolite II
e) Rormals, seasnred as
acid {metabolite IT)
f) BenallT impaired, neasured as
metabolite It
Peaks, after 100 ng fenbufen, single
dcse
Data also for other metabolites and
ether degrees of renal impairment
51-87 rr old patients and controls.
fasted before and after dose.
ORITED KIRGECR! IBUITS; KIDRII
DISUSES; EICOD SEBIJI; II11GISICS:
IRTI-IRrLinBIIOBT IGERTS;
HTIPIIEIICS; DBDSSJ COKPallKITB
ITIUJITIORS; BET1BOIISB; HETIBOIITIS
a) Rormals (creatinine clearance >80
il/iinl , leasnred as unchanged
fenbufen
t) Benally Impaired (creatinine
clearance 3-20 il/nin) , measured as
fenbufen
c) Rornals, neasured as
qamna-hydrcXTT 1, I'-biphenylT-l-fcutano
ic acid (metabolite II)
d) Benally impaired, neasured as
Ktabolite II
c) normals, measured as
••-hydroirM.I'-tipbenyl T-n-acetic
acid (metabolite IT)
f) Benally impaired, measured as
metabolite IT
Peaks, after 800 mg fenbnfen, single
dcse
Data also for otter metabolites and
other degrees of renal Impairment
21-87 yr old patients and controls.
fasted before and after dose.
3SITED KIRSDCR: iDULTS: KIDRET
EISHSES; 31000 SEBUfl; UllGESICS;
JUTI-IHFLftRHlTOPY KGE1TTS:
IKIPTBBTICS; 9*OGS; CO!IP»B»TITE
ITJItHTIORSj BET1BOLISR; RETM01ITES
SEFESEBCE
Bogers, P.J.
SaTitsky, J.p.
Glenn, 9.
Spector, B.C.
1981
clinical Pharmacology
and Therapeutics
29(1) :1»-«
















Bogers, H.J.
Sarltskj. J.P.
Slenn. B.
Spectar, B.G.
1981
Clinical Pharmacology
and Therapeutics
29(1):7«-|o


















                                                                                                                                                                                         Ul
-------
Icetallde, B-aaidino-2-(2.6-dich!.arpBenyl)- (» CI)
Ecnzeneaeetaaide, I-(aiinoiaino>etliyl)-2.6-dlcliloro- (9 CI)
C9-H9-C12-B3-0
HI 216.11
TISSUE ETPOSIRB- BOUT! JHLTTICJI
BETSOD
•680 tngestion SC-PC
Blood.
cells




(
1

1
1
1
1
(DEIZB
OF OSES
b) 10












1


1
1
I
1
•681 | Ingestion GC-EC a) 9
flood, | b) 10
plana I




f 1
1 1 1
1 1
t \
t
\

1
1
1 1
1 1
1 1
1 "682 | Ingestion GC-EC
1 Trine |


















a) ?
b) 10














i(
bl













IMGE 1.EA. SEBM.L WrOBBmOR

I EEFEBEBCE
1
1
a) 5.6-0.91 ng/al a) Bot given a) Erytnrocytes, 3 and 36 kr wans 1 Seiss, I.I.
D) 11.n-1.55 ng/«l b) Bot given after 2 «g. Initial .easureient 1.12 1 Lavene. B.I.
ng/al at 1 hr
t| Erytarocytes, 2 and 36 br aeins
1 Safar, B.E.
1 Siaon, I.e.
after 9 ag. Initial aeasureient, 5.1 | Loria, I.
ng/al at 1 hr
) Estimated froa graphs.














a) 3.48-0.69 ng/al
b) 8.28-1.31 ng/al


















a) vot given
b} Bot ?ivea






1
1
J
1
1
f
1
I
1
1

Rot given
rot given













a) 29.9 » or - 2.5 *
of dose
b) 3". 3 » or - 5.1 «
of dose











23-59 vr olds, no drag > 4 vk before
study, 100 leg/dar *a diet 3 days.
Ill had c&ronic hypertension without
cardiac or renal involvement.

Reduced blood pressure.

CSOG5; DBDG TBEEaPI; 3IPEBTSBSIOB;
JBJHCEJ BLCCD PLtSHl; OBIRtj BLOOD
ISISStTBE: IBITHBOCTTIS; COBPaBanVE
IftlDlTIOBS


a) Deans, 3. t and 36 hr after 2 ag.
Initial xeasureient, 0.76 ng/d at 1
kr
t) Reans, 2.C and 36 hr after 4 ag.
Initial neasareaent, 3.59 ag/al at 1
br
Cata also given for steady-state
values after 1-3 ag 2!/day.
23-59 yr elds, no drug > D vk before
study, 100 leg/day Ba diet 3 days.
Ill had chronic hypertension vithout


[JUGS; 9RUG UTERI?!; HYPIEIMSIOH;
TB1BCE; BICOt PUSH: UBIBE; BLCOD
IBISSBBB; IHIHPOCITES; C08PH1T1TS
mnjTtons
i) 2 ng dose
t) 4 a<7 dose
72 br caaulative excretions in
unchanged foci.

23-59 yr olds, no drug > » «k before
study, 100 teg/day Ba diet 3 days.
All ha4 chronic hypertension vithout
cardiac or reaal involvenent.

Bedacel tlood pressure.
BIBGS; DIOG TBIBIPI: HIPISIEBSIOB;
tsiBCE: sioor PLisni: OBIBE: BLOOD
;«SS!!SE! fSIIHSOCtTES: CCBPAB17ITE
1 Georges, D. B.
1 flllliez, P.L.
1 1979
1 Clinical Pharaacology
1 and therapeutics
1 25 (3): 283-293
1
I
1
1
1
1

1
I

1 Veiss. I. a.
1 Laveae, D.L.
1 Safar. S.I.
1 Siaon, I.e.
1 loria, T.
1 Georges, D.B.
1 nilliez, P.L.
1 1979
1 Clinical Fharaacology
1 and Therapeutics
1 25(3):283-293
t
1
1
1

1


Veiss, T. t.
Lavene, D.L.
Safar, I.E.
Siaon, i.e.
Loria, T.





























U)
-IS
oo












Georges, D.9. (
nilliez, P.L. |
1979 |
Clinical Pharaacology I
and therapeutics
25(3):2M-293



-------
Acetamide, 2-(p-(2-hydroxy-3-(isopropylamino)propoiy)phenyl)-  (8  CI)
Eetzeenacetailde. 1-(2-hrdroxy-3-( (1-methylethrl) amino) pcopoxr)-  (• CI)
S9122-68-7
C11-B22-H2-03
n« 266.31, HP 106-148 C
TISSUE

0683
Blool,
plasma














9664
Blooi,
plasna








EtPOSUB! ROUTE

Tngestion
















Ingestion










AHALTTICAL
METHOD
HP1C



























HOTIBJB
OF C1SES
12



























BARGE
'
716.1-50.5 ng/lll
















1579-15 nioles/1










SEAS

Hot applicable
















Hot given










GEBIBAL IHPOBBATIOH

Heans, 1 and 24 br after 100 ag.
Initial value, 243.5 tig/ml at 0.5 hr.
sab-fects at test.

flcalthy 20-28 yr olds, no cardiac,
renal, hepatic or absorptive
abnormalities. Bo medication > 15
days, fasted overnight.

Besting systolic pressure negatively
correlated vith drag plasaa level.
r=0.521, p<0.01. Heart rate.
systolic pressure, plasna renln
reduced, correlated with plasoa drug
l«vel. p<0.05.
CflOGS; BLOOD PLASHa; BLOOD PE5SS095;
S COLTS; HOSilCDES
2 and 40 br leans after 100 ig/day

Bealthy 20-3C yr olds, vithin 1OT of
norial velqlit.

9edaced resting and exercise heart
rates. Reduced blood pressure.

CBOGS; SBHDIS; B10OD PLASH);
UTIBTPSSTESSIVE AGEHTS; CODPJBJT1TE
IVALOATIOHSi ADD1TS: BLOOD PEESSOBE
BEPEEEHCE

liner, B.
Hason, H. D.
Carter, C.R.
willoaghby, T. 1.
Kochak. G.I.
Cohen, I.
Bell, B.B.S.
1979
Clinical Pharnacology
and Therapeutics
2«(3):315-325






Johansson, S.B.
HcCall, a.
vilhelnsson, C.
Tedln. J. A.
1930
Clinical Pharmacology
and Therapeutics
27(51:593-601



 cetamlde, 2,2-dlchloro-!i-{beta-hydroiy-alpha-(hydroxynethyl)-p-nitrophenethyl)-,  D-threo-(-)-,  (8 CI)
 cetamlde, 2,2-flichloro-H-(2-hySroxy-l- (hydrotymethyl)-2-(l-nitrophenyl)ethyl)-, (B-(B«,B«)) -  (9  CI)
 €-75-7
 11-B12-C12-M2-05
 « 323.11, (IP 150.5-151.5 C
TISSOE

1«S5
Blood,
plasaa








9S1H
Elool,
serum












ZIPOSIJBB ROOT!

Ingestioo










Inlection













aHAlTTICAL
BETHOD
GC










GC













5DHB5B
OF CASSS
1










a) 8
b) 5












BINGE

11-23 ug/ml










a) 11.2-36.2 ug/rnl
b) 10.0-36.2 ug/ml











(BEIT
9EAB

Hot applicable










a) Hat given
b) Hot given











PAGE)
GEBIBAX IRPOBHATXOH

Initial measurement and 1-2 hr after
50 ig/kg, IT daily as paloitate. 16
nq/il at 6 hr. Measured after 7th
dcse.

After hvpophysectomy, 30 yr old vith
haemophilus influenzae type b
leningitis
AULTS; IHFECTIOB: BLOOD PLASBl:
C?BEBB05?IH»l FLDID: SSTIDIOTICS;
CHOC TOEBAPT
a) Peaks at 15-50 mgAg/day
b) Peaks at 25-50 mq/kq/da?

Ion birth Height infants, 1 vith
tacterial infections, a) Ages 1-8 d.
• t 0.9-2.5 liq, gestational age 25-35
vk, and b) ages 11 d-8 vk, vt 0.9-2.2
kq, gestational age 28-31 vk.
ETHHSTlTaHIA; INFANTS; HE1EOEH; BLOOD
S!B01; SPIHAL FLOID; ANTIBIOTICS:
ttiOG THEBIPT; CHIOEIBE OBGJHIC
CCnPOURDS


BEFEBEBCE

Bensimer, E.B.
Pickering, I.E.
Ericsson, C.D.
Kramer, w.G.
1991
Lancet 1(8212) :165





Glazer. J.P.
Danish, H.A.
Plotkin, S.A.
Samner* J.T.
1980
Pediatrics
66(1): 573-578









-------
c«ti«H«. 2,?-«lrt,lor»-«-(*«

t-'J'r-T
• J?J.1«. (IF liO.S-UI.S C
1
1
i*"*"*" !
fl«U 1
i
i
i
i i
i <
i i
•
Spinal |
I
1
1
1
1
t
1

1 a-kj aroiT-alpti- (



rtTtn
X







sc







kr«lroii»«lt'U-!'-iUr=,-i««. »fcrl)-. :>-t»r»o


,eo.
l or c»5«
1


(
f
1




1 lot applicable






_ 1
-!-)-, (8 CJ|


rifsrsj
•?>i















	 	 _ -





(ti
lg/Iq, li •iiilT a; oil>lta«.

3C TC ill «Ub hanaphllni icflntnza*

•rniTS; IPFBCTTCH; BLOCS PLJSRI;
f*3G vnve«pr ' ~ '

60 lin iftrl dos« f25 itj/kg/dar in 2
?«roi 1«T«1. 10. f nq/al


F!1«SriT»»II; I»Pl»ri; JJHP09"- BLOOD
S[«tH: SPI«»[ fltllB; i«TJ?I01ICS;
CCRPfOMSS f
	 ._._ . 1




««"'«


rr*i«r, V.G.





Gl«z«r, J-p.
E«nish. S.Jt.
riottir, 5.4.
Su>*«rr J.T.
Pediatrics




 Ac*tloo].
               IIPOSOII! ItOOTt
It)9**t ion
OIL
B




• !JII»rB
or c»ses
•) 7
b) 6



XMGI
» 1.65-0.3 tq/tl
b) 7.3-1.5 uq/.l



1 ~ niti
1
1
1
*l Kot gir«n
M Not qir«o



t CFItPfc&t IMFORR&TIC*(
1
1
1
*l Contrail. ! «n1 2« hr «(ttr 200
I 11. 7nitl«] BeReurcMint, O.t ui/il
1 4t t br
u<;/il «t 1 he
Mtiiat«d frci qCKph
•!•»» kq. )2-40 rr oil p«tl«nt».
HlOIfll: HTPrBIE».51C»; FID»II
cisr»sf.TiHTp!«re»;Tr» norics; DMC
iPt»«»T: ne»cor«Lrsis
l r;pc»5»c*
Hftrvvnqt, c.
P»n«q«r. J.P.
HuscKart, J.n.
f»rb»«c)l, n.
>?7?
Journal o( Ciintcal

-------
Icetanillde. 4'-h7dro»y-  (8 CI)
aeetaalde, H-(g/l


a) 14-43 ag/ml
b) 0-5-13 ug/ml
c) 180-9 aayal


(HER
1B4H
7.23 « or - 6.33



139.22 » oc - 64.57
ng/dl



...
a) Hot applicable
b) not applicable


a) Hot applicable
b) 6.7 «g/l


a) Hot given
b) Hot given
c) Hot applicable


P1GE)
GBBBBSL IBFOBBITIOS
textropropoiyphene poisoning
fatalities, alcohol and/or other
drugs in lost cases.
Ccroners cases, ages 16-67 yr,
northern Iceland
ccaa, death.
congestion and edeoa of lungs. In
sone, cerebral edeaa.
[BROS; BLOOD: VBIHB; SUICIDE! DBDG
HOSE: ISE1UD
CeitraproFOXychene poisoning
fatalities. Other drugs found in
peat subjects.
Hcithern Ireland
Coaa, death.
Cengestlon and edeaa of longs. ID
Ecie, ooretcjl vdeia.
tBOGS; BLOOD; OBIBB: SOICIDE; OBOG
HtVSt; I8ELIBD
a) 90-210 iln after 13.93 ig/kg at 2
18
t) 90-210 nil after 13.93 pgAg «t 6
18
Bcnoeipoaental decay. 5s ti Bated fro»
graph.
Bealthy 22-32 yr olds, fasted before
ind daring eiperlnent. Ho drags 1 v*
before stady.
BEOGS; 8BTaBCLIS8; » DOLTS; BLOOD
CIlSHa
a) 24 hr values after a single 4 g
dcse. Peak at 2 hr and then decline.
Considerable individual variation
1} levels at Sth day following tvice
B«althy 21-67 yr olds. «t 48-100 fcg
PEI1BCB; 1DOLTS: BLOOD: BLOOD PL1SIH;
IBtlGBSICS; JHTI-IBPLiBBlTOB! JCS8TS;
SBJLGtSTCS; JHTIfTBBTICS; D1TO
TBEBtPT: III VITBO aNlLTSIS; DBOGS
a) 0.5 hr after 30 ng/kg dose
t) 4 hr after 30 mq/ltq dose
O 4 and 16 hr after 250 ig/kg lose
0.5-6 yr olds
vciltlnq early symptom of overdose
CBILDBBE; LIVES DISE1SZS; BLOOD
Htsn: »B«tGESics: DRUGS; HEALTH
BIZlItDS

BEPEBEHCK
Carson, D.J.L.
Carson, B.D.
1977
Lancet 1 (8017) :894-897



Carson, D.J.L.
Carson, B.D.
1977
Lancet 1 (8017) : 894-897




Shlvely, C.a.
VO3O11, E.S.
1975
clinical Pharaaeology
and Therapeutics
18(4)1413-424


Callleai, p.
Callleni, 1.
illsln. p.
Benler, J.-c.
Therapie 34:81-87

Peterson. R.6.
Buaack, B.H.
1981
archives of Internal
Hedicine 141:390-394



-------
icetanilide. H'-hydroxy-  (8 CI)
Acetaiide, H-(H-hydrolTphenil) -  (9  CI)
103-90-2
CS-H9-S-02
BS 151. 16, 9t 169-170.5 C
                                                                                       (COHTIROED)
1
1
Tissns
»6»5
Urine
««96
Urine
1 9697
1 Urine
r
0618
Heine
«6M
flriae
EXPOSURE ROUTE m»ITTIC»l ITOHBSB
HETHOD 07 CiSSS
Ingestion HPLC 8
1
1
Tngestion IP 17
1

Tngestion


1
1
1
1
1

1
13
12
1
<
1
» 1
8JBGE
a) 7.«-27. 3 mg
b) 13. 0-25. » og
C) 26.5-171.0 ig
»2. 0-255.0 »g
1.30-122.00 •g/dl
137-425 ig/dl
a) 0.90-3. 89* of dose
b) 4.6-16. 8* of dose
0) 36.7-61.8' of dose
i) Not applicable
b) Dot applicable
;) not applicable
BE* I | GIIEB&L IHFOBB1TIOH I BEFE2EHCE
1 1
a) 16.5 mg
b) 17.6 >g
c) 81.7 mg
d> 170.8 ig
27.01 » oc - 36.29
•g/dl
1 1
1 a) Free, 6-3.5 hr after 11 dose I shively, C.I.
I b) Tree, 0-8 hr after IS dose 1 resell, E.S.
j c) Gluoironidate. 0-3.5 hr after IS I 1975
1 dose | clinical pharmacology
1 c) Glucutonidate. 0-8 hr after a* ! and Therapeutics
1 dose | 18 (»|: it 13-1121
1 CmulatiTe cicretion after 975-1,300 I
I «q. t
l i
I tcfore stqdy. t
1 1
I HUGS; 1ET1BCLISH; ADMITS; EIOOD I
1 ClftSHA |
1 1
1 |
1 Deitroorof oifphene poisoning | Carson, D.J.L.
1 fatalities. Alcohol and/or ether j Carson, E.D.
1 drags is tost cases. 1 1977
1 1 Lancet 1 ( 80 17) :89«-897
1 Ccroneus1 cases, ages 16-67 yr, I
1 northern Ireland |
1 1
1 Coia, death. (
1 scie, cerebral edeaa. |
1 I
I BEaGS: B100C: HEIST; SUICIDE; DHUG |
I IECISE: IBEUHD |
I 1
221.54 t or - 83.19
«g/dl
a) 2.43^ of dose
b) 12. 8« of Hose
c) »7.6% of dose
a) 0.06 ig
b) 0.58 ig
c) 1.03 ig
1 textrapropoiYphene poisoning | Carson, B.J.L.
I fatalities. Other drags found in r Carson, E.D.
•cst sablects. | 1977
1 lancet 1 (8017) :89«-897
Coroners1 cases, ages 16-67 jr. \
northern Ireland \
I
Coaa, death. |
Congestion and edeia of laogs. In I
sate, cerebral edeia. I
!
ESOGS; BLOOC; HEINE; SUICIDE; DBDS I
IEOSZ: I5ILJBD |
1
1
a) Onietabolized drug | LeTy, G.
b) acetaiinopben qlacuronide f Khanna* N.N.
c) acetiiinochen salfate I Soda. D.n.
It hr cuinlatire excretions after 12 1 Tsuzaki, o.
• g/itg ( stern, L.
f 1975
Healthy 2-3 day old, foil-ten I Pediatrics
infants. | 55(6) :818-825
1
ISOSS; OBI1I; SEHBOIISS; HESBOBM; I
StI I
1
a) AcetaBinophen \ Levy, G.
1:) acetaainophen glucaronide I Garrettson, L.K.
c) lcetaiino;hen salfate I Soda, D.n.
CuiQlative eicretlons 1st 1».75 hr of I 1975
life. Aether ingested 0.3 g I Pediatrics 55(6) :89S
phenacetin S.5 hr before delirery. t
t
Healthy nevbcrn |
1
osncs: MidBcts: osm-, -(ET»BCIISB; i
EBEGBiSCl; CUSE HISTORIES \
1
                                                                                                                                                                                           Ul
-------
Ice tic acid. {2,J-alchloro-0-(2-thienylcarbonyl) phenoxy) -
00180-00-9
C13-H8-C12-04-S
US 331.17
TISSUE
4700
Blood,
sera a



BIPOSOHS BOQTE
Zogestlon



avainicu
BETHOD
ec



BOUSES
OF C»SSS
6



BiBGE
_
a) 0.63-0.55 ng/nl
b) 2.35-H.68 ng/ul
e) 1.01-3. 6B ng/al
4) lot given
el Hot given
fj Sot given



•Ell
a) lot given
b) Rot given
c) Hot given
4) 0.34 • or - 0.17
(SI) og/nl
e) 0.55 « or - 1.20
(SB) cg/al
fl 2.83 * or - 0.59
(SB) aq/il



GB1EMI, IBFOBIUTIOH
e) Days 3 and 4
b) alcohol Mtabollte. days 2 and 4
c) Diaeld aetaboUt«, days 2 and 4
d) Dncnanged drag
e) llcohol Mtabolite
{) Dlacld netabollte
a)-e), 8 11, fasting saaple before
250 ig. d)-f), attar 5 hi
henoaialvsis on day 4
Inephcic 21-50 vr olds, on
beiodlalrsis >12 aoBtha, controlled
diet
lo effect o« else in serno gcic acid
after dialTSis
DIOOS; DBDS THEBIPT; ISROBIUTSIS:
DIOBETICS; 8IUBOLITES: KDBZT
tlSMSIS; StCOD SERDB; PEBB3TH»1IH
BBFZBEHCE
•array. T.«.
Brovn, S.
Dnbb. 3.9.
Bvang, B»t»
Stote, B.B.
1460
Clinical Tharnaeology
and Therapeutics
2T(5|s««6-«89



acetic acid,  («-
-------
  acetic tell. (a-{allTloxr)-3-cklacopae;irl|-  C*  CI)
  BeBzeawcetie acid.  3-calorc-«-(2-prope»jloirt- t» d)
  J2131-7»-»
  C11-«1t-Cl-03
  Rf 22C.CS,  IF M-93  C
TlSSVt
•783
Oriae

mosns JODTJ
lt«**U«»

ininicit
8C

imBJS
OF CaSSS
*) 32
14 W

met
a) lat glvea
b) «.8-»S.7 eg
I
mi
a) 50.4 a?
b) 4*. 2 eg

etinai ziFOBamoi
a] SOD «7 a* nspeuiai, overalgfct
faat
t) 1000 n la cipnle at aeiltlee
Caaalatin 2« be ezcnetiaaa,
EvalthT adelta
BtWSS; IBTX-lrFlftaflafOBI A€ZVTS:
trtiPTsnics: BICOD plasm; aeitt
IERCSTCZ
SeueUe, L.t.
Sa&dera, B.C.
Frieiaaa, 1.
Clielcal PkacMacolagr
aad Tk«np« Hot 9itea
f) rat ?i»a












6FIIBH ZrFOIIlTIOI

•1 2 kepatoaa petleats, dase a5 ao/cq
a
t| a aoa-kepataea patimta, dese
ac-as nj/sq a
c| 3 fcepatoia patients, deM 30 ao/«j
t
d| a noa-baratoat patieata, dase 30
ae/aa •
e) a hevataaa patieats, dase 15 ag/aq
a
f) 1 aaa-lwpata»a patleat, daee 14
0 «»J 25 kr, estiaated Dcoa qrapk*
Cata availatle far eetabolite.
*<-71 re aide >itk kepatoaaa aid
«tkec aeoplaua
»I6S; CBlgOlBSaaPT: CIBIBCSIS;
IIOFIISIS; EtOOB t>I»SHa: COBP1BITITE
•11101TIOIS; BRtBOIITZS; IDOITS
BIIISCTCI

Ckaa, It.S.
Cklebeeski, I.T.
Tong, 8.
Ckea, B.-S.G.
Croas, J.F.
Bateaaa, J.I.
1980
Cancer Beaeacch
«0:1263-126«









-------
tUiia*. 3-(B-(bls(2-cUero*tBrl1aBlao)p>eiirl-. I- <» CI)
1-PkeirlalailM, a-(W*(J-cbloro«tkTl.|aal«o)-  (9 CI)
1M~82~3
C13-V18-C12-I2-O2
HI 305.20, BP nppcox 177 C (decOBp)

»706
Blood.
plasaa






B70T
Blood,
plasaa.







»78B
TJEiBe









*709
Vrtae








ntosan sooti
Injection






Xagestlon







Injection










IneeetloB








tlliTTICaL
HETflOD
IndloaetCT






BPLC







BPLC










BFIC








mnns
or CUES







11


















11








IMSE
3.0-0. OSS «g/Bl






a) 0.07-0.63 ag/nl
b) 0.18-0.31 ag/nl







1.5-21.6^ «f dose










•I 2.»-21.»« of dose
b) S-1CX of do*e








•Ell
lot give*






a) 9.29 « or - 0.15
b) 0.31 * or - 0.11
•1/Bl






13.0 * or - S.a« of
Aoae









a) 10.9 » or - *.9f
of dose
b) 13.2 « or - 3.7*
of dose






et limit motiaiioi
ladlau. 0-6 hr attac 0.6 •«/»« IT.
Ilexponeitlal decay. Ertiaated fton
4Upk.
Cancer patl«Bts, aqa* M-70 IT, *t
a3— §6 kg
E«I«S; CIE10TBEI4PT; 9UEE: HOOD
illSBl: IEOPI1SBS; IISEISES:
IftMOLITES

a) 11 nblectc. nftar 0.6 ag/tq, aa
t) 3 aubleeta. nftec O.t B^Aa. a*
aclatlon
Vaake

29-70 yr old cancer patients, *t
«a-|* k«
tines: CMicnBiin: itomsBS; nooi
(iisii: it HI: conautiTE
tfiinitiois
24 kc accretion aft«r 0.6 a^/kq

caaeer patient*. a«w *«-70 it. at
as-a« k«

MOOS; cmoTBztini VIIIE; noon
CI1SI1; ISOH1SBS! DISMISS ;
tKlBOtlTES



a) 11 aab-|«cts. after 0.6 ag/tq as
tablets
b) 3 a abject i, after 0.6 sa/k« as
aelitlon
2«-ne exccetioBs
29-70 TE old cucec patienta. «t
««-«< kg

DfOSSt CBnOTIEBMT: KOPLaSBS: B100B
msti: mm: COI*BUTI«E
ZTllVHIOVS
BETSIEICI
llberts. B.S.
Chang, S.T.
Cken. B.-S.O.
Evans, T.I.
rarner, t.U
Ilsnelatein. K.
Cross, J.r.

Cliaeal Paarucolofr
and Tberapevtlcs
26O):73-M
tlberts. b.S.
Cku?. S.T.
Chen, H.-S.B.
CTBBS, l.l.
Boon, T.E.
1979
Clinical Phacnacologj
and Thecapaatics
2t(6(:7J7-7«5


tlberts. D.S.
Ghana, S.T.
Cken, B.-S.5.
BOOB, I.E.
Evans, l.i.
ram*r, B.t.
Blanelstel*. I.
Gross, 3.1,
1979
Clincal Pnarnacology
and Therapeutics
26(1): 73-10
alberts, b.S.
Chang, S.T,
C&ea, f.-S.S.
I rans. I.L.
BOOB, T.I.
Clinics 1 CharMcologr
and Therapeutics
26(6):737-TI5



-------
  alDna-f t-n-Olo-I-isoiDdolinjDphenrllpropioaic acid (go postings in CREILXR) .
TISSIJB
(710
aiooa.
plasea










IIPOSUOT BOOTS
Ingestion









I
i Mi-men,
SET HOD
GC










BWWSB
OF CiSIS
1










MUGS
a) 1.0-7.5 ng/al
b) 6.0-0.7 ag/«l










Hill
a) lot applicable
b) Hat applicable










eziiMi, moBUTiai
a) d-enantiover* 0.5 and 1.5 lie
after 200 mg cacaiic aiKtare. Final
leatnnaent, 1.8 ug/il at 10 hr
H 1-enantloier. 1 ud 10 hr after
200 • as btoiida. 61/iaf

iTastkenic patieot. U.S.

MOGS; BLOOD 9USU; SSiSDSIKIT
8ITBODS: OflTID KIISD01




EHFESIBCB
DlTison, S.C.
Ffman, f.
Prentis, S.I.
Dehqhan. 1.
Chan, K.
1980
Methods and Findings IB
experimental and
Clinical Pharmacology
* <2) -.77-62
                                                                                                                                                                                           Ui
liiontai,  (o-bro«obeniTl)sth7ldi«etbfl-, p-tolaenesilfonate  (8 CI]
I«neB«etkaraainin«, 2-bro»o-Ii-et!>Tl-».1l-4i«etiTl-, salt »itb a-Mtkilbenienes»lloi.lc  acid  11:1)  [9 CI>
«1-75-6
C 11-B17-Br-».C7-ll7-03-S
«« «!».», HP approi 98 C
IISSOE
•712
BlOOl,
scna










EIPOSDE? SOOTF
Tnjection
laoestioa











illtlTlCil
KETIOB
SC












IDBBn
OF ClStS
10












B1WGE
a| 38-1*3 «?/«i
b| 1134-2«36 nq/al











I»1W
a) 76 ng/al
b) 1896 oq/ll











GEiieii T»ro«ai7io»
•) Feat after 5 «o/*g, oral
t| Peak after 30 «ln IT. 5 i^Ag

lealthT. 20-«7 rr olis, Michigan

iniietTr fleshing, eiclteaent.
increased blcod pressare and heart
rate, liTTio«ss, nasal congestion.
transient headache aid nausea in
EC a*.
(ICBIGIH; 1DDLTS; BLOOD SEIOfl; IT5I1E;
IITTHTPnTIlSITf 16ERS; DHOGS;
CCIPlBlTItl ETJUOlflOKS
BBFEREBCE
Inlerson, J.L.
Patterson. 1.
(aaner. J.G.
Stevart, J. B.
Beha, n.l.
Incchesi, B.3.
19BO
Clinical Fnamacolog7
•ad Therapeutics
23(«):««8-«7»



                                                                                     (HIT P1GE)
-------
insoiinn, ro»l>e«nietnTl4lBethTl-. p-tolaenesnllonate (6 CI)
BeareneaetlLanaBlnivB, 2-broao-*-etn7l-t,*-dinetBTl-. salt with 1-neUiTlbanzeiwsalfonic add (1:1)  <9 CI)
61-75-8
C11-H1T-Br-».CT-HT-03-S
n »1».a. IF appro* »8 C
                                                                                      (COtTMMDJ
TISSSS

• 713
Blood
aerui












»7ta
UriM











nposuas ROJII

Inlection
Tngastioo













Zn faction
Inaestion











IHITTIC11
HRHCD
ec-sc














EC












WDHBIB 1
or cisss
aj 6
M 7













10












I USE

a] 2.5-0. 08 og/sl
b) 72-»61 ag/ll












..
a) 0.3-0.9* DC dosa
b) 0.1-P.2* of dose











BSII

a) lot applicable
b) 1»« tg/ml













a) lot giYen
b) lot glTBB











GIKBIL xnOlMIIOI

») Initial muuaMat av4 2n hi
altar 5 >g/k tosTlate

Ociiae patients, «*-77 ji all, oral
thecapr after 3-7 days ol IT thicapy.

Tulabla, aostlT postural.
bytoteaslon litb oral tkarapy.
ItDlTS: CilBIOTISCTUlB BISHSSS;
t!IST DISUSIS; BLOOD SIBDB;
iiTiiBEaiianjc lerats: DBOG TSBBIPI:
CllSntKHR IREOOS
a) Beak a IMC 3D ala IT. S aa/kg
t) P«at aftet S t-ci/k-?. oral

HtaltM. 279



                                                                                                                                                                                            OJ
 InillM, a.a'-salfonTlil-  (8 CI)
 Mni«Mailn«. «.*>-siilfonTl1>ls-  (9 CI)
 SO-08-0
 C12-H»i-»2-02-S
 H 2»».30, »P !75-t7« C
TISSDt
•715
31ool,
scrat

















EXCOStnt! BODtE
In«eatlon



















tlUTTICU
IWHOB
riioroaetty



















gOSBIB
OF C1SES
6



















1»GI
a) 2.5-0.1 19/1
b) 3,0-0.02 »g/\
cf 2.0-0.07 •?/!
fl) Z.S-0.03 «g/l
a) 15-0.5 mg/l
I) 10-0.34 *j/l














Kll
j.
a) vot giTeo
b> Tot gi¥en
el Tot gli«n
}) lot giren
e) lot giten
I) lot gireo














CtltUI. HFOBHITIOI
al Dapaan* dose 100 ag/day, 5 dars
-------
  iBiliae, «,«I-sslfo«Tl4i-  (> CII
  Beimteaslae, »,a'-salfonTlbl»-  (9 CI)
  (0-08-0
  CTJ-»12-»2-02-S
  If 2*8.30, IP 17S-17S C
nssn
»7M
Or IBS
cxposm IODTB
laeestios
aiaimcii
•craoi)
rlioroeetry
•HUB
OF C1SIS
«
Hies
i) lot given
b) lot given
e| lot gina
d) lot given
*) tot applicable
f) (at applicable
szi» i GintiL iirotnnoi
I
i
•) 16.C » or - 1.1* | •) tavsoae. «o*e 199 eg/daT, S dar*
of Aw* | (ttam 1)
b) 9.9 » or - O.SS of I 1} after 118 9 activated charcoal
lorn | 10-58 he after last dapsoae dose
e) 6.3 « or - O.M of | (rkase 2)
too* | c) 9oaa>»tTiaapaoa«, phaaa 1
i) *.2 * or - t.ZX of | l| amote*tTld*f>s-*-clil0ro-2-((2-facaaylMt)iTl)"li'O>- (9 CT)

C12-»f1-cl-»2-O5-J
9> 330.77, BP 20C C
CO
Ui
oo
IIJSOB
«7I7
Blood,
plasaa
nrlae

Exrosras torn*
Injeetloa
laJeetioB

8TTIOD
DC
SC-JC

JOBBBS
or cuss
c
16

1IICB
a) 750-604 nq/al
b) 7SO-tS8» ng/al
a) 22. « 0-73 .4*. of lose
b) 3.]-ao.*« of dose
c) 0.13-3.92* of lose
inn
BUI i GEKUI urotnnoi
1
i
a) lot gives I a] Initial acasareaent aid 2.5-3 fcr
b) Hot given I after IT kolas of TO ag, then
1 coBtlneons lafnsioa of 8 ag/hr
1 b) Initial eeasareaeat and several hr
I attar 1 gs crobexcid IT 2.5-3 hr
1 after start of iufnsioa
I !«se valves tstlwted fro* gnph.
1 BtalthT 22-2t rt olds, welqkinq 7« «
t or - 8 kg, fasted before dose.
1
1 sacked diuresis
1
I noes; SVZDEI; TUIIE; BLOOD 111911;
1 BlntmCS; BIOS IREMCTIOI; lOfllTS
1
a) 56. 0* of dose | a) Oichaiged faroaealda
b) 10.784 of dose I t) Contagated fvroseaide
c) 1.88* of doae | c) Icid aetabolite
aadlans 1 21-hr caaelatlv* ezeretions after
1 2C-UO «g farosuid* Iseaa dose *
1 «7.2» *gl.
1
1 2t-88 Tr olds «ith ante pvlaoaarT
1 edesa, «t »*.»-100 kg, sose OB other
1 liags, soae with acote avocardlal
1 itfacction.
1
1 tunes; atTiBcusa: BCTIBOLITIS;
1 CIIIOI; DI01RICS: tM5TOE»n
1 EitMDS: BBIIT oiSBisss: aim:
1 ccapitHTUt EuimTiois: IDUITS; MUG
I Tinivr
(
•a6B|
fiBTSBERCX
Odllad, B.
Beernaan, S,
1980
Clinical pharaacology
and Thenpentlcs
27(«)s78S-790
Fetei, J.
Sltar, D.S.
Ogilvie, (.1.
1979
Drag Retabolisa aid
Disposition
7(«J:383-38T

-------
littmllle acid, a-chloro-B-farfnryl-S-selfaeojl- |« CI)
ieaiole acta. *-faeiaonlfoiyl)-*-chloro-2-((2-feraaylnethyl)aBiao)- (9
5«-31-9
C12-B11-C1-BS-OS-S
81 330.77, 8P 20C C
CI)
tlSSBl
•719
Brine



nposviB ton*
Injection



IMITTICH.
BSTHOD
ec



BOBBES
or cisss
6



1UGI
a) 2.86-3.21 ng/30 ill
b) 1.75-1.25 if/30 (in



mi
*) not given
b) lot given.


i
Gzitaii iiroiitnoi
.
i) Initial Btasicmeat and 2.9-3 hr
•ft«t IT bolus of 10 ng, then
contlnnons infnsion of 8 ng/hr
b) Initial aaanreaeat and several ir
after 1 qm probenecia IT 2.5-3 he
aftur start of lifasloB
Sea* Tala«« catlaat*! £COB qraph.
I«althT 22-21 re <>14», nlgUaq T« *
or - B *a, fasted before flos*.
sar*«4 ainreals
Dines; sinzi; nr»; BLOOD ntan;
D MIMICS: DSOS mnicnoi: IBOITS
nnmci
oaiiaa, B.
Beermii, B.
1980
Clinical Phanacology
ai8 Tk*rap««tlcs
27(«)s7M-790



            (• CI)
3H-rrr»»ol-3-on«, 1>2-ai>raro-1.5-aiMthrl-2-pbmrl-  (9 CD
$0-80-0
C11-B12-12-0
81 188.22.  RP 111-113 C
1ISS8S
«720
Blool.
plasaa












»721
Bloo4,
plBSBB







»722
Saliva








Mfosoits toon
Isolation
'












lB4*StiOB









lagastioB









•IlLTIICaL
1OTBOD
HI












OC









ec







,

IOBBBS
or cisss
10












11









11







.

Hies
a) tot given
b| Bat gl*an
c) lot giT«B
A) Bot giT«B
•) BOt giT«B
f) lot given











11.5-26.0 ng/Bl









12.5-29 ag/il








(BUT
n*i
a) 2.21 ag/al
b) 2.18 «g/al
O 1.M »9/sl
4) 1. M ag/il
e) 0.*5 ng/al
f) 0.35 ag/Bl











Bot given









Bot given








MG1)
6SBI1U IITOIBMIOI
a) Control ai«t - 3 hr
r) trnssels cpoBte «»4 catbage aiat -
3 nr
c) Coatrol diet - 9 hr
i) Erv*sels tpronts a*4 cabbage 41et
- 9 hr
e) Coatrol diet - 30 hr
f) Brassels (pouts «n4 catbage aiet -
30 hr
1) Dose »as 1.8 nq/kg
9-30 hr valves sigalficantly
aiffereat
21-32 vt old*. »t 50-79 Itg.
icnaaokers, fasted before and after
dose.
mass; gins; BIOOB PLISBI;
inuoinis: coBPUtnvx imainoBs
Peaks. 3 hr afer 18 ngA?
Talne* hiqhlr correlated vlth saliva
valves. BoBoezponeatial decline.
Istlnated froB graphs.

Eaalthr adnlts. aqes 22-30 rr.

ItOHS: BtOOD PLIS81; SUITt;
iiiicesics: jiTiPTsmcs: Dives:
CClMBlllrj CTIlIITIOfS
Peaks, 3 hr after 18 ag/kg.
BOBoexponential dec 1 lie. Zstlaated
fres graphs.

(ealthv adalts. aqes 22-30 vr.

ltD»s; BIOOC PltSITl; S11IT1;
liaiGBSICS; anipnZTICS; MUGS;
CCTtlBITITS Et»LO»TIO5S

KniEBCB 1
I
PantocV, B.J.
Pantack. C.B.
Garland, B.a.
Bll, B.H.
Batten berg. 1.1.
anderion, K.I.
Kappas, 1.
Conner. »-H-
1979
Clinical Pharaacology
and Therapeutics
25(1): 88-95





Vesell, E.s.
Passananti. G.T.
Glenvrlght. P. ».
Dvorehik. B.H.
1975
Cllaleal Pharaaeologf
and Therapeutics
18 (3) -.259-272


Vesell. Z.S.
Passananti, G.T.
Glenniqht, P.I.
Dvorehik, B.H.
1975
Clinical Pharaacologv
and Therapeatics
18(3): 259-272


                                                                                                                                                                                         Ol
                                                                                                                                                                                         VO
-------
 latipyriie  (8 CX)
 3B-Pyra*ol-3-one. 1.2-dih7dro-1,S-dinetkTl-2-pkeiiyl- (9 Cl)
 60-80-0
 cn-ai2-»2-o
 HI 188.22, HP 111-113 C
                                                                                       (COITIIOED)
TISSUE
«723
Brine














EIPOSI1BT ROUTE
Tngestion















lIUlTTICm
HETHOD
TIC
<3C














•DHBS1I
OF C»SES
1















H1ISE
a) lot applicable
b) lot applicable
c) lot applicable













•Ell
at 33* of dose
b) 17* of dose
c) 17* of dose













GEMIU IIFO1BITI01
i) la •-kydrexrantierrine
t) Is 3-aydroxyMtliylantlpyrine
c) Is lorantipyrine
0-50 ar cneelatlre excretion after 1
g

70 kg, vkite asle pkenotyped as "poor
•ataboliier" according to capacity to
t-kydroxylat* debrisoguine aid
sparteine.
DSDSS; ggttBOllSn: gSTUOlXTES;
OII«I: COSP151TITE ET»10»TIO»S:
SfDITITBS; BTPBOTICS; iBTIPIBETICS;
IITIHT?WTE»SIYE 16MTS;
IITHFBBIIHBIC 1GKITS
1
BEFZRBRCI
Inaba, T.
Of ton, 5.T.
Kalov, V*
1980
Clinical Pkariacologr
and Therapeatics
27t«):5»7-5»9









IBtlpyTlae. »-(di«ethTlaaino)-  (8 CI)
3B-Prrazol-3-one, H-5-aiaet]iTl-2-phaa7l-  (9  CD
58-1S-1
C13-B17-113-0
HI 231.2». BP 107-109 C
TISSOB
«72»
Blood,
plasia
»T25
eiood.
plasia
•726
Saliva
3XPOSm>I FOOT
lagestioo
Ingest ioa
laqestlon
KlXTTICItl
MTHOB
GC
oc
sc
iOHBSS
OF C1SES
12
«
11
FJKGB
». 5-6. 2 ng/Bl
a) lot gireo
b) lot glTeo
1.7-7.6 og/»l
mil | GEtiui iiroiflinoi
I
i
Hot glrea | 3 be after 9 Bg/kg. 3stiiated froa
| gtapfc,
| KaltkT adults, ages 22-30 jl.
| 1 EDITS; BIOOD PllSHl! SUITl;
| H»ieiSICS: MTIPTBETICS; BBOGS;
| CC'PIFITITE irilffHtORS
|
a) 8.01 » or • 2.52 1 a) Dose, 2 ig/lcg at 8 >.H. aftec
•g/1 kr | 12-hr fast
b) 7.96 * or - 1.13 I b) Dose, 2 igAl at 8 P.B. after
•g/1 kr j itnal aeal at 5 P. a.
I liea under tbe carve for free * bound
I drug
| ffcalthr 22-31 yr olds, wt 59-85 kg
| PHKSTLTiKU: »DOLTS; BIOOD FllSlil;
I IHIGtSICS; IITIPIKBTICS: DHOGS;
I CCIPIRITITE miomofs: DIRS
1
1
Hot given | 3 hr after 9 eg/kg. Honoexpoaential
| decline. Rstieated fron grapk.
I ecaltkr adults, ages 22-30 rr.
1
I It HITS; BIOOD PUSH; SUITl:
I IHlGtSICS; HTIPIFETICS: BFOTS;
| CC8PI1ATITJ mlOlTIOIS
BKFEBEBCE
resell, l.S.
Passanantl, G. T.
GleaRlght. P. a.
Drorchilt, B.B.
1975
clinical Pkariaeologr
and Therapautics
18 (3>t 259-272
Sbirelj, C.I.
sinons, B.J.
Passaaant, O.T.
DTorekik, B.F.
Tesell. t.S.
1981
Clinical Pbaraacology
and Tkerapentics
29{1):«5-73
Vesell, t.S.
Passanantl, G.T.
Glenvrigkt, P.I.
DTorekik, B.H.
1975
Clinical Pkanacology
and Tkerapeatics
18 (3) J 259-272
-------
Barbitaclc acid. 5-(1-eyclohe«en-1-Tl)-1,5-dl»ethvl- (6 CI>  nil)
2,l.«(1».3H,5in-PTrlsidinatrione, 5-(1-evclahex«n-1-yll-1.S-diMthrl-  (9  CI)
C 12-B1S-I2-03
•I 238.26, SP 1*5-1*7 C
1ISS1!

*727
Blood,
plasaa







«728
urine









txrosoif soon

Injection








.
Infection










II1LTTIC1L
WTHOD
GC









GC










IOBBIS
O? C15BS
1









at 6
b> 11









BUS!
_
a) 4.3-12.8 »g/l
b) 12.8-2.0 ig/1








a) lot given
b) tot given
cj lot given
d) lot given







mi

a) lot applicable
b) lot applicable








a) 02.3 * or - 13.6 *
of dose
b) 12.6 » or - «.1 «
of dose
O 0.31 t or - 0.13 *
of dose
d) 0.33 » or - 0.2« t
of dose




GEI1B1L tirOIBlTIOl

al 5-60 a la infusion
D) 0-720 aia post-lafasioa
Cose, 556. 2 ig (7.32 ng/tql as sooin
salt. Biezponentlal decay.

60 vr old hepatitis patient.

DSTISS: BCTaBCLISB; IDOITS;
CCHP«B1TIVE HVIIOITIOSS: OBIITi BLOOD
PUSItl: LlttB DISUSES
a) controls, 3>-fcetohexobarbital
t) Patients, 3*-ketohexobarbital
c) Controls, nnchAaged dreg
dj patients, snchanged drne
2*-hr cuniilative excretions after
i. 97-7. 32 eg/kq as sodium salt. TV.

17-t2 vc oil patients *lth ante
kepatitis, healtbr controls.
5S1SS; BtTkBOLlSH: 1DOLTS;
CC9P181TIVE rrilnitlOKS; tISHE: BLOOD
PtlSSl: 1ITIB DISUSES
tmsEici

Breiaer, B.O.
I ill*. «.
Richter, 1.
1975
Clinical Pharnacologv
and Therapeutics
18(»t :»33-»»0



Breiaer, D. D.
ZillT. *.
Itichter, I.
1975
Clinical Phanacology
and Therapeutics
18(«):*33-aao





EarBitaric  acid,  5-ethTl-5-(1-nathflb«tTl)- (8 CI)
2.«,B(19.3R,5H)-CYrlliiiiietriOB.e,
7e-7»-»
C11-H18-I2-03
US  226.31
UJ
1ISS9!
«7»
Blood








a730
Blood.
plasu







8731
liver








riposns! soari
._









- . -









-










1IH.TTICAL
KETEOD










SC



















HHHBI5
OF CiSES
1








-
«









1








— --
BlIGE
lot givei









2-7 aaoles/1









lot given









BE1I
1 »g/ml









S. 25 uiolee/1









52 ug/g









eiifiiL iiroRnnoi
titopsT staple

** Tr old pharaacist, suicide.
cverdose of ether drags

OB3GS; DSTC IBIS!! 3DTCIDE;
1DTO95TE3: ClSZ BISTOBtES;
tUS11BlB»I RETHO9S; IEV ZEIllXI;
EIOOD: LtTEl; OSIIE; ItlDNSIS; BDIIK;
ItCCHOLS
36 he after last of tea, 0.1 q daily
doses at bedtiae.

»OBS«okinq 23-37 TC olds, «lth no
evidence of disease or drag intake.

DUDES: HWH8O11SH: SKTSES:
BiPEiinisioi: BIOOD PUSH*; DBOG
IlrnaCTTOI; 1DOLTS; COHPi»a«TE
imoaiiois
AntopST aaaples

44 yr old pharaacist, saicide.
overdose of ether drags

CETCS: DBUG IB3SI! SltlCIBZ;
lOTOpsus; CSSE HISTOSIES;
!ftlSDBE!(!1fT BETBO95: DEI ZEItMl;
iiocD: LiTti; D?I»E: KIBIITS: BRII*!
IICOHOLS
ixjsastcs
.
Qneree, E.a.
Oickson, S.J.
Ussen, i.e.
Pannell, L.K.
1979
Journal ol inalytlcal
Toxicologv 3:253-255



Collate, p.
Seideean, P.
Borg, r-O.
H&gltno, I.
von Bahr, c.
1979
Cliaical Pharaacologr
and Therapeutics
25<«):*23-127

Oneree, K.I.
Dicfcson, S.J.
nlssen. 1.7.
Pannell, I.It.
1919
Journal of Inalrtical
Toiicology 3:253-255



-------
larbitarlc add, S-ethvl-5-lsopentvl-  (8 CI)
2,a.C(lB,3H.SR)-PvrinldiBetrlone. 5-ethjl-S- (3-nethylbllt

C11-B18-B2-03
If 22C.2T. BE 156-158 C
)- J9 CI)

•732
Blood.
plasna
«733
urine
*T3«
Brine



ngeatioa
aiunzcit
anioD
or/as

ec/ss
IBBBSB
0? CUBS
a) S
b| 5
el 5
9) 5
1
67
11151 ' "MB 1 B1IIS1I, nrOSBUIOf
1 1
1 1
b) or3S-5."2 Jig/al | b) 2." 53 If/Il [ I) iMnatls (coVds} *of ^ *" 1"' "*
c) 0,59*1.5 ng/al I e| 1.16 ng/al | c) lothecs, 60-110 nq phenobarbital
8) 0.26-1.2 ug/«l | d) 0.82 .g/nl | daily » 1 dose asobarbital aoring
1 | labor
f 1 d) Weonates (cords) of e).
1 1
1 I 17-42 IT olds, treated «ith
I | tartltarates for hypertension in
I | pregnancy, and their nenbora.
I | »OGS; SBWBOBB; PBEGUBCT;
I | BTPBBTBBSIOI; SEDHITSS
t 1
1 1 	
a) tot applicable 1 a) S9t of dose (70. « | a) Is 3-hTdrczTuobarbltal
b) lot applicable | at) I t) Is anobartUal-I-glncopymnoside
1 b) 12< of dose (1«.» | 0-100 hr cotolatii* excretion after
I ag) | 120 ng
t I
1 | 10 kg, unite nale pbenotvped as "poo
1 I Mtabollxer" according to capacity t
I t 1 i-hrdrozvlate debrisoqnine and
1 I icarteine.
1 1
1 | DBBG5; RBTlBOLISa; »ST1901ITIS:
1 | OlIIE; COBPIIITITB ITIIDITIOIS;
1 | SfOaTITBS; BIMOTICS: »»TIPHBin:S:
1 I UTiBiPiBTiisiyE tsnrs:
1 I I«IH!»HTTB!!IC 1SCTIS
1 1
a) lot given 1 a) »6.1 * or - «.7 | a) 29 Orientals,
b) lot given I nnoles/1 1 3«-nrdroiyasobarbital (aetabolite)
c) lot given | b) 59.3 * or - 2.1 | t) 13S Caucasians,
d) lot given I aaoles/1 | 3<-hrdroTTaiobarbltal
e) tefsiven | c) 39.1 * or - 3.1 | c) 29 Orientals,
f) lot given | inoles/1 j l-(beta-D-glacopTranosrl) anobarbital
g) lot given I d) 29.2 * or - 1.5 I (aetabollte)
1) lot give* ( neoles/1 | a) 138 Caucasians,
1 e) 59.5 * or - 2.8 I l-(beta-t-glocopTraaosrl) anobarbital
1 aaoles/1 1 e) 93 Caucasian sales,
t t) 58.9 * or - 3.8 | 3<-nTdroxya»abartltal
1 anoles/1 | f) «5 Caucasian sales,
1 g) 27.3 * or - 1.6 I 3l'hTdroxyanobarbital
1 ONles/1 | g) 93 Caucasian nales.
1 h) 33.0 + or - 3.0 | 1-dMta-g-glneenyranosyl) aiobarbltal
1 uaoles/l 1 b) *5 Caacasiaa females,
1 s.B. | t-(beta-o-glocopyraaosyl) anobarbital
1 | lto«t 36 hr aftec 60 ag anobarbital.
t | Oriental and Caucasian Mdical
1 | stadents.
< 1
1 | CBBGS; *ICIK STOBIBS: SKIBOLISIT;
1 | CCRrillTITZ miVlTIOIS; OHIBJ StTC;
1 | IITABOLITZS: C1B(D1
' 1
«««,«
Draffan, S.H.
Dollery, C.T.
Daiies, D.s.
Kraner. B.
tllliass, r.E.
Clare. S.»,
Trndiager, B.J.
Darling, 1.
Serial, B.
Havkins, D.E.
197C
Clinical Pharaacology
and Therapeatics
19(1)t271-275
Inaba, T.
Of ton, S.T.
Kalov, V.
1980
Clinical Pharmacology
and Therapeatics
27 («): 5*7-5*9
Tang. B.C.
radar, 9.
Bndrenyi, 1.
Chan, T.-1.
1979
Clinical Pharaacology
and Therapeutics 26(6) :
7*6-776
1
-------
larbitarlc aclJ, S-etafl-S-PaenTl-  (> CIJ
Z,a,«(IH,3H,W)-PTri«idi»etrionB, S-ethyl-S-paeByl- (9 CIJ
50-06-6
C12-EI2-B2-03
•I 232.23, SP 1T4-1T* C
1XSS1B
»735

Slool.
plasaa

*737
Blood,
Btasaa
•73*
BlOOd,
plasaa

B731
Blood,
serna

1IEOSOS3 BOOTS




Ingest IOB
Tngestion



1BH.7TICM.
iznoo


EC

sc
ec/is

HPLC

»OS8BB
or cuss
i

36

a| 70
b) 39
6

12

B»ez
cot given

10-37 ng/sl

a) lot given
b) lot gives
a) 1.38-2. »0 ag/al
b) 1.23-2.25 ttg/al

a] 12. 0-25. » ng/1
b) 13.3-24.7 ng/1
c) 17.6-23.1 ag/1

Bill
B BS/Bl

vot given

a) 11.05* » or -
H.89 ng/il
b) 9.097 * or - 10.10
ng/nl
a) 1.90 * or - 0.36
b) 1.68 * or - 0.38

a) *ot applicable
b) lot applicable
c) Tot applicable

6IIZU1 IiroiBlTIOl
totopsy saaple
• 4 yr old pnaraaclst, salclde,
overdoses of other drags
DSB6S: BSOG ISO 51: SUICIDE:
imopsits; cist msiosixs:
BHSmtmiT RETRO9S: in IIIUID;
nooi: IITBI; DBI1I; KIDIETS; BKUi;
ITCOTOtS
Paspeclfted dally dosages.
pegvtlvelv correlate* «itb plasaa
reala concentration, r» -O.a«7, p <
O.D05.
15-55 yr old epileptics, on
pkeBobarbital > 3 • oaths.
CBies; inicosTOisaits: BLOOD tusxa:
iiscoisn
a} Rales. 2-> he after 1.15 * or -
1.»H aq/tq
t) resales, 2-* kr after 1.16 * oc -
1.703 aq/tq
tatients on aainteaanee doses for
selzues.
iBiiconTDtsarrs; woe IHIBIPI; BLOOD
EIJSFH: S»; DEOS inSBlCTIOl;
a) thcBobacbital, 60 ng
%) Pbenobarbital, 60 ag, plas
valprolc acid 4250 ag 2x/day starting
• flays before)
a) «ad b) not different, p > 0.05.
loraal 2VMO hr old Caucasians, free
cf any drag.
tines; aim; inHacnot: isous:
S1CCD PLlSRti SIBIIITSS; ITPKTICS;
mTCOITVLStRS; IRT&3OLIS!!
a) Means, after 1.J-1. * eg/kg/May,
IVflay regiaan, 10 snMects
t) Beans, after 1.3-5.6 ngAg/day,
11/day reginen, 10 subjects
c| Beans, after 3.«-5.6 ng/tg/day.
31/dar reginen, 2 snbjects
1-3.3 yr olds, infrequent seizures
mm; BIOOC SCSOR: CBILBE!>; DBTSS
ainmcE
Qneree, E.a.
Olckson, 5.J.
Blssen, a.I.
Pannell, L.K.
Jonrnal of Inalytical
Toxicology 3:253-255
Booker, H.!.
Gooatrlena. T.I.
Tevksbory, D.a.
1S7»
Clinical Pkanacology
and Iherapeatics

Schaeffer, 9.J.
Janardan, (E.G.
Sonani, S.fl.
Zaston, O.
Sbernaa, D.
1980
Toxicology and Applied
Pbarnacology 53:35*- 36*
Fatal, I.H.
Levy, R.B.
Cntler. B.I.
1980
Clinical EKarnacology
and Therapentics
27 W.S 15-521

Valsoa, t.D.
Rliaki, T.
earless, P.
nayersohn, 1.
Perrler, 0.
19SO
Journal of Pediatrics
97 (2) : 303-305

(HIT PaGZ)
                                                                                                                                                                                            LO
-------
larbltaric acid, 5-
1 1 Dickaoa, S.J.
f *• jt oia th*n»dat, sniciie, | Hlssaa. l.'-
1 o«rlo3«s of other drags t Pann«ll, L.K.
1 1 1979
1 HOGS: D*0S 1BHSI; SDTCIDE: I Jaurmal ol Inalftica).
1 IOTOP5ISS: CIS! RTSTOHISS; I ToiicOlogT 3:253-255
I nusmsmT IRHODS; in ZEILJBD; i
i siooD: LITSR: mm; KIDIIIS: smii; i
1 tICOBOlS |
1 1
1 t
) Rot applicable | a) Mans, after 1.3-a.a .g/ig/iaT, I Salson, P.O.
) »ot Applicable I 21/aay r«qi«e», 11 subjects I RiaaU, T.
1 rot applicable t t) Beans, after 1.3-5. « a4/t4/lar, f Cnrless, I.
1 1V4a? r«gi»««. 11 anhjeetB | Rarersohn, •-
1 e) Beans, after 3.4-5.6 •g/kg/Aar. 1 Perrier, D.
1 31/itj Ttgiftn. 3 subjects | 1980
1 1 Joacnal of Peaiatrlcs
1 1-8.8 ft olds, infrequent seizures I 97 (2): 303-305
1 SHTTi; BlOOt SZ10R; CBIlDSKi; D»IG$ I
1 . |
                                                                                                                                                                                               OJ
Eeazaaite.  a-(acetTlaaino) -»-(?-{diethylaaino) ethrll-
327»5-a»-1
C15-S23-B3-02
• I 277.11
1 TISSUE
1
I--
1
•7«3
siooJ.
elasaa









ETPOS088 B00TB
1 0 1ec t ion









lutnmi i insBM
BFTHOD | OF C1SSS
HPLC









$









BliGE
24-45 n?/«l









SZ4M
30.7 ag/aj.









6EIEBU IfFOKIaTIOl
(caks, 30 ain after 15 ag/kg, IT.
TciezponeBtial decltae. Istiaated
froe graph. Dialysis increased total
clearanc* a-fold.

FnactioaiallT ««phric 33-5« TT olds.

lo side effects.

DB1GS; BLOOD PL1S91; 1DDIIS;
CISnS!Sl TI1IKOIS; COSPIBITITE
MtlDtTIOIS
tun USB) 	 	 	
tmttfcx
stec, G.P.
ItUison, l.J*
Kevin. S.J.
Theaot, J-P.
EUO, T.I.
Sitsoa. T.P.
IianoTich, F.
del Greco, T.
1979
Clinical Pharmacology
and Therapeutics
26(51:618-628

-------
Eennside. «- (tcctrlulao) _»- (2-g at 50
ig/iii, IT. contlaooBS axponentlal
tecllne. !«tii»t«d fcoi frapb
Coge as hi4rochlorl4e.

35-38 rr oldl, fasted before aid
after dose*
to effect on pvlce rate, blood
preasmra at electrocarlio^taa.
CftUGS; BLOOD PLISSI; TL1IIOIS;
«lSlT»ME!rl HFTBODS: DBUI; 1DDITS
2* tr urines after «2«-(«3 *q, oral.
and 5 tin 11 o£ 2SO aq. Dose as
hylroelilarlde.

35-38 yr olds« fasted befoze and
after dose.

lo effect on pnlse rate, blood
picH«re or eleetneardlograi.
ipifGS: BIOOD ptisni: ILLI>OIS:
giismism Hitnos; OHIII; IDUITS
pinmct
strong, J.n.
Oa tclier, 3.S.
Lee, B-K.
Itllnson, 1. J. . Jc.
1975
Clinical Phareacolocji
aal Therapeatlcs
18(S)<.613-«22





Stroncj, J.H.
Ditcher. J.S.
lee, «-!(.
ttkinson, k.J. , Jr.
1*75
clinical fharaacoloqj
and Tlerapeotics
1« (5) J« 13-622



Eeitlenepropaaaelna,
?a« 10-89-3
C17-B18-'3-«-O
81  309.33
TISSUE
»7B6
Blood,
plasaa












titosatt tone
-
Ingestion














immcu
BBTHOD
SC-JC














•DBBE3
OF CUES
4













-
SHOE
a) lot given
b) lot given













-
a) 1«7 ng/sl
til 87.5 ng/nl














a) forflmietine Mtebolite. days
17-30
tl fluoxetioe, dars 20-30
tose, 30 aa/daT for dars 1-7 and 20
ng/dar foe days 23-30. Steady state
levels.

loraal, 21-50 Tr olds on nodified.
enteeholaiine-free diet.

Vedaced platelet serotonin levels and
uptake. lo adverse side effects and
no bekavioral effects.
INKS; IBDIln: B10OB PIISHI;
mmms; IIVLTS: SBIG inEncnoi
_ _ _
Lenbetger, 1.
Sonet B.
Cartlchael, 
-------
   Eencanesilfonnlfe, 2-chloro-5-(1-hTlroxr-3-oxo-1-isoini!ollnTlt- fs CI)
   leat«a*silfonaaide, 2-chloro-5-(2.3-dikrdro-1-lijarorr-3- i esiEML iwroiamom i swEiBircs
l i
i i
a) O.t27« ng/1 1 i) SO •4 6 he after t Tv«e£4ale, B.C.
1 tto 190 ig tablata. Oet«ctabla at 1 I Oglltle, E.I.
1 he. rival Masnieieat, 1.5 »g/l at 5 I 1*7)
1 s. | 1979
1 1 Clinical Pbaciacologr
1 8«altBT 20-32 rr oils, rt «5-88 tg, I ani T),erapc«tics
1 fasted OTenight. | 25<«) : 806-812
I icnss; Diapmcs: IETHIBHIDS; i
1 iroLTS: OBIVZ: BLOOD PUSH i
i i
i |
at given I Daily «zccetlan after 190 ig/dar for I Tweeddala. I, G.
1 > 1 math. { OqllTie. I.I.
1 I 197«
I Reapitalized lea. | Journal of
1 | Mtaraacentlcal Sciences
1 C1HDI; OS1GS: RIlSITHBIirT BET HODS : | «3(7) 1 1065-1068
1 EIOOI; VRIIE; 1 BOLTS |
	 _ _l )
Emolc acid, p-(Uproprlsalfa>arD- (8 CI)
teizaic acid, a-((dlproprlaalno|salfonrl>- (» CI)
81 285. 3«.  «F 191-196 C
1 TI5SVE
• T51
Slool.
serai



ElfOSDE! IODTI
Inoestioo



1 AR11TTICU
RETiioD




or CISES
3



HVGX
a) 21-116 ag/al
b} 25-154 ay/ml



Mil
a) 58.7 ag/al
b) 71.7 ig/al



EE«mt ITPOtnTIOl
a) Before •et«otrecat«
b) Ifter 15 ila IT of 3.0 g/sg a
aethotrexate sttrtlno on day <
steady state geoaetrle aeaas 12 hr
before - 21 fcr after aethotrexate.
1.7 g/sq n prebeneeld giTe* la t
Jl Tided doses.
Cancer oatlents, ages 20, 2«, and *7
Ti.
la toxic effects.
csoss; Dins incitcTioi;
-------
Kittle ada. p- «ipi«JTls«li»»OTll - (8 CI)
Msolc acid. 4-f(41proprlaaliio)s«lfoiiTlI-  (» Cfl
C13-1H-1-O4-S
If J85..3S, BC 194-1« C
IISSOI
4T!2
urine



EXTO31BS KODTft
'
Ineestion



lIlLTTIClt
3KTOOD
_




iinsa
or cisss
3



I1IGE
12-34* of dallr «
lot given




tally excretion ou 1.7 q/sij a in 4
aoses/lay. unaffected daria  2-c*rtairph«iTX eater
 !«2-9»-J
 C1»-«1»-OS
 II 256.23. HI 230 C
ilSSDS
4753
Blood,
plasaa





SIPOSBW tout! 1
1
laoertio.







llltRICtl
.
BPLC







•IJBB!S
or c«s!s
i







UISE
- -
0-33.4 aa/>l







SUI
-----
•at gives







ei«i«i iiroMiiici i
1
« &m« 1 kr after 1000 a-3.>-dit>rdEoxT-,  [-)-  (9 CI)
                                                ffl-  (9 CI)
 S1-4I-2
 C8-«11-»
 Bl 16*. 16, IF HI C  (Jecoap)
tISSSI
475*
Blood.














f
I
I

BIPOSBH lodtl



















iiumcii.
RET8OD
.

Intyiatlc

















OF CASK
_. .
12


















sues
•
a) Cot ?lven
b) lot gi*«a
















(Will
mi
a) T50 » or - 66
na/Bl
b) 349 * or - 34
n^/el
e> 51 » «r - S a^/al
sx












PIGt)
eiicut iiroiunoi t
a) 4 kr after Hose
b) « kr aftet dose
el 24 hr after dose
Simile 100~a9 dose

BcaltkT 20-21 Tt oVfls, no carilac.
renal, kapatic oc absorptive
ataarsalitie*. 10 eeiicatlon > tS
aars. fasted oveiDlght.

lelaetia* 1« sfstollc blool pressvre.
beart rate, and plaaaa real*
activltT. Increases la plasaa
acrepincpkrise at rest and daring
exercise, tttectf correlate »lth ing
level aaf last at least 24 hr.
giTiGS: stooc pus^i: BIOOB ;nssmt^:
IDVLTS; ROEIOnS

nmtiCE
liner, 1.
HasoB, l.D.
Carter, c.R.
SllloaqhbT, T.I.
Koctak. G.I.
Coken, I.
Sell. S.H.S.
1979
Clinical HiaraacologT
and Therapeutics
"26 (3V 1 3 15-325








-------
teazrl alcohol.  alpha-(aalnonethvl1-3.4-Uhviroxv-.  (-)- (8 ci)
t.2-Be»*MdioI,  4-(2-a*.iiLO-1-nrdtarvetlivl|~.  {81- {• Ct>

C8-H11-1-03
B> t«9. ia, Rf  19! C  (decosp)
                                                                                        (Coming)
IISSOS
•T5S
Blood,
plasaa
»75€
Bio**.
plan a
557
e loo.l,
• note
*758
Ovarr
81 POSHES 10

Inlectlon
njection
lection
alllTTICal
HIT BOD
Radiosetrr
Xnvsatic
Bnzynatie
ladlonetrv
ilonetry
BDHBEB | BtUSI I HS»I I CIIIEIL IlfOBHlTIOJ t BZfJfBESCB
or cisis i f i i
lit i
1 II I
1 a) lot 9iven I a) 29S pg/»l I a) Controls, supine I lake. C.E.
1 b) lot given 1 b) 4*8 pg/*l I b) Controls, standing ( Hikkeisec, J.J.
1 c) lot given 1 c) 232 ft/ml I c) Tnuretics, seplne I Bapoport, J.I.
1 fl) lot given 1 3| S15 pg/ll | 4) Entireties, standing I Zavadil, 1. P.
1 el lot given 1 e) 293 pg/al I «l Rmretie*. supine, ox 75 *g/l*r 1 Kopin, I.J.
1 f) lot given 1 f) 667 pg/»l | iiipraiine at nedtiae I 1979
| | j f) Snare tics, standing, on 75 ig/diy 1 Clinical Phamcologv
| f | isinraaine at bedtiae | and Therap«atics
III 1 26(5) : 697-653
1 | | t* nacetic tors, *em me 9.8 » or - 1
1 it 1.9 yr. 16 controls, nean age 9,7 * 1
1 | | or - 2.* yr. 1
III 1
1 | f unties: csiiDBM: BLOOD PBESSTTPB; i
| | | HCO0 PLI5IH; OFffS TBIS1PT |
1. 1 1 .... 1
III 1
S | »J *>t gi»«a t a) 0. 19 * or - 0.07 | a) Prelose | Htzo«rald. 6. 1.
I b) lot given I uoVl I t) 0.01 og/*q/«it I Rossunn. T.
I c| »ot giTea I b| 0.239 * ot - 0.1 I c| 0.92 vj/kq/min | Ha«llto«, C.I.
| 4| Hat glrett I aa/l t J' 8-*3 »«/*9/»i« 1 Beld. J.I.
t «) lot glTan | c» 0.212 * « - O.OS | «J 0.05 nq/kg/vin I Diti«s. D.S.
I f) »ot gl»e« I »g/M 1 *» 0.075 ugykg sin | Dollery, c.t.
1 I 1) 0.219 » or - 0.08 | 10 sin Infusion rates I 1979
t I ng/1 1 1 Clinical Flianacologj
I f e) O.SJS » or - 0.09 1 BcalthT Caacaslaos. ages 32.* » or - 1 and Therapeutics
I | ng/1 | 1.9 yr, nonssokers, no caffeinated I 26 (6) :669-675
I | q 1.34 * or - 0.4 j drinks For «S hr (
1 1 ag/1 1 t
j | j Incrcaseil blood nnssare and reJaced I
j j j heart rate correlated vita dose |
III 1
i i i rsaes: BLOOD ptisii: BIOOD VKSSSDB:; i
| | ) "ITT) 1CHG3CB: 10BLTS I
1 1 1 1
III 1
) 5 I a) lot given | a) 2.8 nCi/g I a) lea-pregnant, peak. 1 iln after 1 Saarlkoslcl, 5.
1 12 | VI tot given | b) 1.65 nCi/g I deae I 1980
| c} Tot jiT«n I c) 0.27 ncl/g j fc) Pcexnant, peak, 1 mi« after dose I tseriean Journal of
I d) (ot gi*en I 3) 0.20 nCi/g I c) lon-pregnant. 5 sin after dose I obstetrics and
I e) Jot give* | e) 0.05 oci/g I i} Pcegnant, 5 aia after lose I Grneealogr
I f) lot given I f) O.OS nci/q | e) Son-pregnant, 2*0 lin alter lose I 136(8) : 10*1-10*4
I | |f) Precrnant, 2*9 nin after dose 1
j i | Zctinated frcn graph. Dose. 50 net I
I | | (1.1 ngl in-labelled 3r«q, IT I
111 1
I \ i Patients nospltalizel for 1
1 | | sterilization or abortion. Dean »t, r
I | | 63, 2-65.2 kg. I
III t
I i | CFVGS; *acc»iircT: BIOOO; rin»»; t
I i i IITMDS: n*ni: OTHBIBS; OTIDOCT: t
1 i i ccHPiimn tritattiois f
i i i i
III 1
* I a) lot given 1 a( 0. 7 » or - 0. 1 (a) (os-pregnant t Saarlkoskl, S.
* | b) lot givtn | nCi/g | b) Pregnant | 19RO
I t b| 0.3 « or - 0.1 j ? a in after 50 uct (1.1 ug| I HmecictD Joarosl of
1 1 nCi/g | 13-linelled dng, TT 1 Obstetrics and
III 1 Gvneeologv
| | | Patient* nosFitalitel for I 136(8) : 10*1-10**
I | | aterlltiatton or abortion. Ke» vt, |
I | | €J.2-«5.2 kg. I
III 1
1 i i DSUGS; pifeiiKT; BIOOO: riKimi); i
| | | !TE*J
-------
e«»rl alcohol, alpha-(asisosetkTl)-3,4-Uhy4rozr-. ft- (* CXI
1.2-geuenedlol, 4-(2-aBlno-1-hrdroxTethrll-, ffl- ft CI|

C8-H11-1-03
B« 169.18. BV 191 c (decosB)
IlSSt)!
4759
OTidnct









4760
Vrlii*









4761
otens








KiMsnB loot*
XBjectlon









TaJectioB









lajectloa








nitmcu
BCTflOB
ladioMtrr









xadiOMtry









ladioaetrr








man
or cases
a) 5
b) 2









10









») 5
b) 12








CHOC
a) 3.5-2.2 BCl/g
b) 1.1-0.6 «Ci/g









a) lot given
b) lot given









•1 1.4-1.2 nCl/fl
b) 0.8-0.5 DCi/g








a»>
al lot given
b! lot glm









at 39.3 » oc - 1.3t
of 4o»
b) »3.1 » or - «.OK
of flow







•1 lot given
b) lot glrao








GEI1U1 HTO1BITI01
•1 Im-pccgnuit
b) Praqaant
8H9* of Mat*. S «»d 30 li> after 50
nCi (1.1 nq) U-Ubellei drwj. IT

Tatieats fcospitiliiea for
«t«ttliTitica oc abortion. Baan »t.
C3.2-«f.2 ka.
muss: TIIGIIKT; BIOOD; Fimio:
OISI03; Htlll: OTUIE5J OTIDOCT;
ccflPMtiirt rfiiuitiois
«1 loa-preqmaat
b) rreqwit
2«-hr axeretion*. *ftec 50 »C1 (1.1
aa) H3-l*bell«a dnj. IT

Patients bospitalixel for
atarllliattoa at abortion. Ben *t.
63.2-«5.2 kg.
ones; «Bfci»icT: Biooti: THHHD;
ntlBus: 08iit: OT»IES; OTICWTT;
CC8P1BITITB BTILOmoiS
a) loa-preqnant
t) Preqiant
lange of Mans. 5 ana 30 ai> after SO
aCi (1.1 aa] B3- labelled drna, IT

fatlents kotpitalizea for
•terilixatien or abortion, lean «t.
6J.2-«5. 2 da.
tVKSSl *tE6IMCT; BLOOD; nitWD;
BTtBUSi UBIll; OTUIES; OTIDBCT;
CCgPHkTITT mLIKIOlS
BEFB ESICE
saarikoski. S.
19BO
laerlcan Joarnal of
Obstetrics and
Grnecologjr
136(8) :10*1-10»»





saarikoski, S.
1980
taeclcan Jonrnal of
obstetrics and
Grnecologf
13« (8) : 10*1-10«»





saarikosU, S.
1980
» aerie an Journal of
Obstetrics and
GTaecoloay
136 (»)t 10*1-1044




                                                                                                                                                                                          LO
 beti-^aittcocrraioiidaroaic acid,  CTanoptenTleethrl. (E)-
 1332-94-1
 C1«-«15-1-07
 «« 309.77, tir 214-216 C
TISSO?

4762
Blood.





4763
Trine






SIPOSOBE BOOTE

Ingest ion
Injection





iBgestlon
iBlectloB






1IILTTIC1L
RETROD
OC/HS





SC/IIS







ROBBZB
OF CISIS
1




-
1







BUGS

180-60 ng/sl





•ot given






	
	 Bill 	

Vot given




-
IS sg/al






	
CtllllL IITOBHTIOI

teak at 1.25 hr aafl 7.75 ir, after
(.0 g til.

Cancer patient.

CEIGS; TTOPIISRS: BLOOD PllSBl!

2.25 >r after 6.0 g 11. 717 of doae
recovered in 24 kr.

Cancer pitient.

DIIIGSl 1K>PUS*S: BLOOD FLlSBl;
Will. CBEPOTHEB1PT

ntzvttct

lines, fl.H.
Kovach, J.S.
flora, K.P.
1973
Research Cononicatlons
in Cheaieai Satloloqy
22(1):*75-1»5OSJ
lees, fl.B,
Kovach. J.S.
riora, J.r.
197*
Research Coananicatioaa
in Chemical Pathology
and Pharnacologr
22(1): 175-1 85
-------
  Bctanwnlde, »-(3-ecetrl-»- fZ-hydro»T-3-1 (1-MthTlethTl> aaiao) neoDoxy) pheaTl) -, (»-(-
  37517-30-9
  CH-B28-I2-O*
  II J3«.«3, ft 119-123 C
TISS3S

•7«»
Blood,
plasna






«7«5
Orlaw











ntOSOIS BOOT!

Infection








Injection












IIUTTICIL
BXTBOD
•rac







-
HPLC












•tfSBSB
or CISBS
5







-
5












BUM

13*C-»C*2 oj/1








a> lot oiF«B
b) lot giro
c) lot give*
It lot given









Bill

2700 » or - 1323 «g/l








a) 30.3 » or - «.«S
of dOM
b) 30.8 * or - *.5F
of dose
c) 1».9 » or - 3.3*
of dose
1) tT.e * oc - I.Of
of Sow





6i»tu urosHinoi

teaks, after 0.35 «gA?. IT

B«*lthr 29-«« rr olaa, wt 65-82 k7.
fasted before lose.

D10CS: «»TIHtPMTEISITI 1SKJTS:
loons; FIIIC:; iioot pusm; usiiri;
BITHOIITIS

a} VncbaBge& drea, 0-2K br excratioa
t) VBChanqeit dr«9, 0-T2 br excretion
c) «-«cetTl «et«l>olit«, 0-2* hr
ezcretloe
d) l-acetrl Mtabolite. 0-72 hr
eiccetton
rose, 0.35 ca/ki, IT.

MaltliT 2»-«« TC oils, wt 65-82 k«
fasted before dose.
ciues : jtmnnBTMSiri »GB»TS:
tBoiTS: rtticB; BLOOD ntsui nni:;
XtltBOHTIS
I BIIB»EfCS

Bom. 1.
Floant, B.
Cbaa, B.P.
letic, s.
Lnesko, I.
t»S9
British Journal ot
Clinical Fhan«colo4T
9s2tS-217
Boar, t.
noerat, B.
Chan, «.P.
tetae, B.
lacsko, fl.
19»0"
British Jonrnal of
Cll&lcal pharmacology
«t 215-217




latiroaln
12T7J-JS-S
met coaposittot oinoii OB CIDITEISIIID
U)
^j
o
TISS9C
«7C<
Blood,
pinna




Ttiae


IIPOSMS BOUT
Injection




Injection


IH1TTICJI
BITBOD
Bicrobloloeical







•DBI2X
or CISBS
6




6


mes
a) 32-5 ng/al
b) 20-2 ng/nl
c) »ot glvei
d) tot given




«ft-123« of dose/2» hr


mi
a) (ot given
b) lot given
c| 9.6 ag/tl
d) 16.3 ug/al




•At of d«e/2a hr


GEIflat I«*OSSITIOI
•) 1 anl 8 be after slnale IB dose,
12 ng/tg, peak at 1 hr
b) 1 and 8 kr after single IB dose, 8
•9/k peak at 1 be
c) lean peak. Jar 1, dose, 300-900
» lean peak, day* 2-7, dose, 300-90C
(a tints, aoes 5S-82 yr. *t 92-190
11.
transient dirtiness
Ilavated liver ensyies
> CHITS: ntficTioi: BLOOD; BLOOD
eiisBi; UBIWB; HHBIOHCS
Base, ISO-900 ng/day.
F«tle«ts, ages 59-82 vr. *t 92-190
Ib.
Transient dizziness
Ilevated liver enxyaes
ItSITS: IirrlCTTOB; BIOOD; 1IOO9
Piism: win: IITIBIOTICS
Birnncc
Keener, B.E.
Coodler. i.l.
1975
Journal of Clinical
Pnaraa oology
15{1»):«9S-S99




Keener, B.E.
Coodley, C.L.
197S
Journal of Clinical
Pnaraacologr
1S(TO) 8«95-S99


-------
            en
1«-Pvria«-2.6-dioM, 3.7-dlh}aro-1,3.7-triMtlTl- (9 CI)
SB—0*-1
C8-B11MM-O2
81 191.19, HP 23B C
TUJIl

«7««
Blood




»769
Blood.
alaaaa







• 770
B1004.
plasaa
















»T?1
Bleo4v
Sana










»772
Cerebrosp
iaal
fla.14






ciposm icon

laoMtioTi





Xalactioa









Insertion































iBleetioB









alUTRCIL
BII7JOD
nc















BPIC


















mjc






















mm
or CISBS
1





,









a


















2












,









MM*

lot applicable





6. %- 12. 6 a 9/1









•j 0.00-0. 18 na/al
b] 5.90-10.93 os/al
c) 5.99-8.95 ag/Bl
d) 6.97-7.60 a«/«l
a) 6.BO-7.10 ag/al
ft 3.92-7.04 eo./al
q) 2.80-5.97 a«/al
h) 2.0S-l.ao ij/al
1) I.D7-I.19 tKI/Bl










a) lot gi*ea
b) lot glues











6.5-13.3 •«/!









Bill

1B.1 ig/100 Bl





e.9 .,/j








_
a) fl.08 » or - 0.05
ag/Bl
b) 7.75 » or - 1.12
B9/BL
c) 7.86 * or - 0.65
aq/al.
d) T.M * or - O.la
a^/al
•) S.82 * or - 0.15
•7/al
fl 5.70 * or - 0.69
Ba/Bl
ql ». 53 * oc - 0.69
Uq/Bl
111 3. 1« » or - O.S6
aq/al
i) 0.«S * or - 0.63
ai/al
(S.B.)
a) 9.16 * or - 2.aa
•9/1
b> 1.3* * or - 1.71.
•9/1









8. SB aq/1









eiimi nvoiMtxor

UtopST. Sasttic contents caatalaad
11 4 of drnq

19 jc old
cues; camm: ILOOB: aowpsns;
tTBS 1BH3I
Saaav of aaaas, after 7-16 day* OB
aalBteBancv do^e of 2. 5 Bo/lco/day.
Plaaaa aad CSP caffelae correlated.
c-0.92, KO.OOt.

Ipaelc pceaatvre Ufaata, gestatloaal
ade* 25-32 «k. poctaatal ages 3-96
dayt.
citiim: nines: CIMDI: BLOOD
fiiSHi; CBSiitosprni THJIB: IBTUTS
•I It tlae ot dose
b) If ME 0.5 ac
c) after 1 hr
d) If tec 1.5 hr
el after 2 hr
fl lft« 3 bt
el after 5 kr
a1 after 7. S ar
11 kfter 3« ar
I«llovl*« 300 a
-------
   caffeine  (8 ci)
   1l-»ici»e-2.<-diaae, 3.7-dihTilro-1,3.7-trl*«th*l- (9 CI)
   58-08—2
   C8-S10-1M-02
   Of m.1«. BF 23» C
                                                                                         (CORXIDXD)
tissng

«773
Carebras
Iral/ren
ricalar
{laid












«TT«
7rl*«













MPOSSSI ROM

































million.
SZTBOB
«PLC
















sue














•ma:*
OF CISIS
2














.

•) »
b) 11
0 3
« 2
•1 2










IMGZ

•} tot given
bl lot given















•] (at glT«n
b) *ot giro
e) lot give*
4) nit lirtv
e) fat gir«t










mi i GEIEMI npoiuTio*
1
t
l) 8. «2 « or - 2.42 | •) Caffeine
•4/1 | b) Tfceopbrlliiw
b) t. 00 » or - 1.54 t Steady state aft*t eatfalva: 15
•4/1 I •«/*« loaJlm doa«, 5 ig/kg/12 hr
t Miateuiiee
1 Data also glv«D Cor th«opliTlli&e
1 See**.
1
1 Freiatm 5-» 4ai olds, 30 >k
I gestational *«•. birth «t 1,13t-1,6»«
1 9-
1
I iHKin; c»iFrr»t: TRaranLitcs;
t BIOOD SIBVt; CEKIBIOSPItlt FIIID;
1 Hies ; OBB5 TBIB1PI
1
1
a) 17.5 mg/l fO.66) | *) 0-1 «o
b) 21.* »5/l (0. f 2) t *> t-2 »o
d 15. » 19/1 (0.511) | e) 2-3 mo
t) 15.3 ag/1 (9,23) 1 a) 3-* 10
e) 1*.2 ag/1 (0.02) I «) T-* «o
I Values la pareataases ar« nlar
I Ccaetloa ot elaaranca. Plaraa lervls
1 aatatalMd bctvaaa 5-20 ag/1.
1 ia»boci», aqad « daya-f ao, tcaatai
1 vita caffalna for apnaa or naar-alss
1 sudden Infant death.
1
I cross; gave tsniti-. ICTBOBS;
1 C»TFBI1?: VBXR: tDBTIBULItfS:
i BltlDOlISB: H»SVRE»n IET8C9S; 1SI
UFESnCE

soaail. S.B.
»tiaa»«, I.I.
Bada, U.S.
I960
Journal of Pediatrics
96 («)! 1091-1093











lldrldoe, I.
traada, J. r.
•ai», I.I.
t«79
clinical Pbaraacologr
aait Ikerapaatlc*
2S{«| :«»7-*S3








7MO-TJ-J
C*
Itt (O.OB, BJ 850 C, SP 1««0 C, TV 10 la Hq at  1»3 C
USSOK
»775
nrloa





1
1
t
1




zxposim tovri
Tafasttoii














t IHLTTICsL
I rarioD
us














HTBBSB
OF CISIS
10














timt
«) lot fir«a
6) lot gtrao













BE* I
 0.26 » or - 0.08
9/dar











sfiiut ntrog«irro»
a) Prenatal npplaaant «itk ieaa of
0.2«5 q/dar, total lltate of 1.37
a/dar. Data froa 2* T-d«r
ciparlcaatal periods
E) Dns«apl««atcd diet, total intake
of 1.39 eVdaT. Data fro* 23 T-dar
eiperlaegtal periods

calTetsltT stndeats a*d eaplOT««s. a
n«ca« aad a teacher. Itlliparou*,
ages 19-2S JT.
Ca nteitio* the «a« OK bolt diets.
itmssn; unit; no*: cucwi:
iieizstgii: nil in is: »nospimi I.S.
1979
t*«rtc<* Jounal of
Cllateal latritioa
32:286-291








-------
caaahor (8 CI)
ElCTelo(2.2.1)heptas-2-OM. 1,7,7-triaethTl-  19 CI)
76-22-2
C10-H1«-0
(« 132.23. at 179.75 C (corr., op«m capillary, 2  »  diai), BP  20* C
TISSUE
•778
Blood.



EXPQSVIV ROOTS
Ingest ion



IIILTTXCH
SCTHOD
GC



RIBBEB
OF CliSSS
a) 1
b) 1



BUGS
a) Rot glT«n
b) lot give*



Bill
a) 1.95 ig/100 al
bl 0.0015 ag/100 al



GSIEB1L XITOBUTTOI
a) 3 yr old 7 hr after 11.79 al Ticks
Taporub (0.7 ga eaiptorl
b) 2 yr old, 20 ala after U.79-29.tS
il Caapho-Pheniqne (0.5-1.0 ga
caaphoc)
Bichigaa chiUrem hospitalized alter
Ingesting toxic aaonnts of
Bill rhlaortM, covgh, lov-giada
ferer, confusion ««d irritability.
eaatric apset and projectile voaiting
fcllo«e4 by conTolaions.
<1ICBX.SU; CISE HISTOSIIS; CBILDaill;
ELOOD snail; DBBCS
BE7EBSICC
Phelan. B.J.. XXX
19T«
Pediatrics
57(3):«28-»31



 Carbaate acla,  (2-(«»(2-hTdro»T-3-( t1-a«thylethyl)aaiiio)
                                                                              -, Mtkrl ester,  (<•-)-
 C1«-B26-I2-0»
 Ra 278. M
TISSUE
-.
•777
31004,
plasaa
EIMSHS1 »OOU
lB«astioa
IMlTTICll,
HITHOD
8C-IC
IMS!?
or CISKS
at «
b| 2
c| »
UIGB
a) 1*2-251 ng/al
b) J10-350 ng/al
C) 616-850 iq/al
HEll
a) 19S.5 * or - 51. »
n 7*3.75 * or- 91. «
»9/»l
GtltUL HTO5BITIOI
a) Peaks, 0.5-1.S kc after SO ag
b) Peaka. 1.5 kr after 100 ag
c) teaks, 0.5-2.0 ar after 200 aq-
BcalttT 18-29 Tt olds
tSOSS; BLOOD PLaSn: IOOLTS;
CCHPlUHITt ITltOlTIOIS
sznmcE
Carrrtlurs, S.G.
Pentikainen. t.
Coaler, J.P.
RzarnofC, 0*L.
1979
clinical Pharaicology
and Therapeutics
26(S);«82-«65
                                                                                                                                                                                            u>
  cefotatiae do postinqs  la CBMLIII).
I 115301
1
1778
Blool.
serve

»77?
Slool,
sera a
HXPOS1F! BOOTE
Injeetioi

In lection
IIJITTICM,
BE? HOD
licrobielogietl

Ucrobiological
•tnBss
or cisss
a) 5
b) 5
c) 5

12
B1IGE
a) 37.9-1.0 og/al
b) 102.»-1.9 ng/al
c) 21». 1-3.3 ng/al

9.1-1.9 ug/al
Bill
at 7.65 «g/al
b) 17.5 ng/al
O 33. S ag/al

lot glren
6E1RII laTOBBtTICI
-
a) SOO a? 4c»
b) 1000 ag lese
c) 2000 aq dose
ti»e-aTerag« Beans after S all IT.
laak at 5 tic
lata also far aultiple IT and 19
doses
22-33 Tf olda, wt 75-81 kg.
UlIISIOTtCS; BLOOD S15BH; >BU1TS;
U»ME! COilPlBlTITI! ZTaLOaTIOIS: BEOBS
1 aad 3 kr after 1 g
Haige of leans
1 CHITS; BLOOD SEIDH: IILK;
IITIBIOTICS; DKOGS; UCT1TIOI
BETEtEECB
(en, B.C.
Asvapokee , P.
ra, s.*.
Catthijisei, c.
1980
Clinical Iharaacologr
and Therapeutics
27 (5): 677 -685
Kafetlis, r.«.
Siafas, C.I.
Geoigakoponloa, P. ».
Papadatos, c.J.
1981
Jet* Paediatrica
Scaa4inaTlca 70:285-268
                                                                                       (IBXT PAGE)
-------
 Cefotarla*  (Bo porting* la CKUIH).
                                                                                      (CORIIOBD)
iissai
»780
•ilk
»7B1
drill*
1XHS1HE BOOT!
Injection
In lectio*
IBUITICIL
HIOTOD
BicTODlolofleal
Ricrobloloaical
nun
OF C1SSS
12
•t s
bj S
ct S
BUSS
0.32-0.13 *g/*l
» lot «.l«ei
b) Vat gi»«
c) lot ffi»*i
mi
lot ;i*en
at 5»* of doee (295
••»)
b) 52* of do** (520
Hi
e| *M of dose (9*0
•0)
GBBHiL iBroiunoB
2 and 6 kr after 1 «. Initial
aeaaiTeient. 0.15 ag/*l at 0.5 ir
Baig* of MIBS
JCTJITS; B1OCD S»m ; BIIK;
IKiBtovics; D*nss; ticiinoir
•1 590 19 ioa«
b) 1000 W) «o«*
e) 2000 •« Acs*
2« kr •xcrctioKS after S ill IT
22-33 TC oldi, «t 7S-»« k«.
HUSIOIICS: BLOOD SUITS; JIDUIIS;
DIII8; COSMMtlfB EVllflltlOtS: DBOGS
1
BRtmCE
Kaf«txi«, 0.1.
slafas, C.I.
Georqaltopoolos, ?.i.
Papaftatos, C.J.
•Mtf
»cta Pacdlatrlea
$cuiina*ica 70:2S5-283
>*o. I.e.
>*«apot«*. t.
Ta. K.f.
Bo. I.
Battkijsn*. C.
1960
Clitlcal Pbaraacologr
and Th«rapeotics
2T(5):6T7-«iS
Celcnlcine (9 CI|
leetaside, B-<5,«,7.9-t*tnh]4ro-1>2,3>10-t*traMtfcoz7-9-on>baazo(a}heptalea-7-Tl]-.  (S|-  (9 CIJ
(•-86-9
C22-B2S-B-06
II 399.13, If 1*2-150 C
ixssn
IT>2
Blood,
•«r»«











nrosn: torn
Ih4»stloa





••







IHLTTIC1L
BTSCB
HI













IOBBBI
or cisjs
*> •
t>) 2
o) 3
d> 1










Buei
a) 1-2.5 *g/al
i) »-U Bj/»l
c) 1.5-S.5 ag/il
d) 9-13 ag/»l










rej«
*) Bot ji»«B
b) Hot gir«
cl lot giT»B
d] lot gir«a










eciiBii nroiBino*
a) 30-1*9 fit aft*r 1 K doa*
b) 11-210 ill) aft»r 2 (4 d«».
rtsponlero
e) »S-21» »li after 2 •? do«.
B«»«SVOBd«ri
d) 15-210 til after 3 ag dose.
B0acespoik4«r
nta also for IT Solas

Catieats with faallial Hediterraaean
f«»«r
Diiss: isFiii; BIOOD snaa;
iiismnnt IBTRODS; gisiisxs;
slime BFFKTS: rare raisin
BiniEICE
Balkia, B.
9aaT. S.
Cree»ald, 1.
Shiaps, T.
Tirosh. B.
1980
clinical pbaraacologr
and Taerapeutlcs
2B(1):S2-«7





                                                                                                                                                                                        CO
Cctinlae  (B CI|
J-PTrroli
-------
CdtimlM (8 CD
J-FyrroliaiBCae,, 1-tethyl-5-(3-pyrldlayl-,, (S)- (*  CI)
•16-56-6
C10-B11-12-0
Bl 176.21, 210-211 C at 6 » Hg
                                                                                      (COBTIIOZ91
«SS9«
B78S

»78S
Brlae

•716
Brine

SIP03UK MRS
IBhalatiOB

lahalatloa

IBhalatiOB

IBIIRICIL
HRBOD
til

BI1

oc

BOMB
or cists
a

a) 21
b) 30

58

MBGB
a) l.t-a.] eg/24 hx
b) I.S-S.a ag/2« hr

a) Bot gltea
b) 0-t Bg/dar

lot gi»ea

nil
a) 3.0 + or - 1.0
b) 3.18 » or - 1.6«
•9/2* he

a) 0
b) Bot givea

106 * or - 13 (SB)
sq/100 Bl

GBIZ11L IBFOBB1TIOI
a) » days OB 22.5 » or - 6.3%
b) * days on 27.25 * or - 10.5
clq«ett«s/d*7» *-*• ag Bicotlne each
20-30 TT old saokersi IB good health,
aalatalalag noraal *ao)tUg habits
StOKITC; IICCTIBB; BIOOO 711SHI;
lOBKCOS; CCBMBimi BTUOMIOBSi
It SITS; EBBOCI.OBI1S; IUBE
a) BoB-saokcn
c) Saokers
Bospital patieats vithoat renal or
JtOntS; BICOTIMs BRtSOtltSS;
J1CLB; ^lITtS BllSBSZRm BITBOSS;
TCB1CC03
laadoi saaplcs. IB subgroup *lth
coBBtaat dally cigarette coBnaftion,
a«Bber SBOked correlates strongly
•1th cottaiaetcreatialne ratio
Begalar saoker* atteBdlaq Infarction
clinic. O.K.
iCfllTSt BX1BT DISC1SK; DBIBZ:
CCBPIBITITZ miOlTlOBS; BE1SVHIBIBT
BBTBODS; HCCnii; BBTIBOIITZS;
SBORIIG
ssrzUBCi
Bill. ?.
Bargaardt. B.
1*80
Cllalcil Elaraacology
ani Therapeutics
27(5):«52-«5S

Batsacara, S.
Sakaaoto. 1.
Selno. I.
Taaada, I.
1979
Clinical Bhataacolog}
and Therapeatics 25(5
lilcoi, B.O.
Bvghee, 3.
Xelasd, J.
1979
British Bedical Journal
2 (6197): 1026-1028

CCBBazlB. 3-(alpH-ac»toiiylb«iiyl)-a-l1Tdroiy-  (8 CI)
2B-1-aaaxopyraB-2-«B«. a-ijaro»r-3- (J-oio-1-pk«Bylb«tyl) -
81-81-2
C1»-B16-O*
Bl 308.32, BB 161 C
                                                               CI)
IISSOl
»787
Blood,
plasaa















xirosns MVtz
iBjectloi
iBgestioa
















iBiinicu.
BZTBOD
BftC
















-
BOBBSK
OF CISSS
,
















--
t tarns
a) B.7-0.2B ug/al
b) 5.8-0.17 ag/al
e) 0.76-1.99 ag/Bl
a) O.S6-1.89 Bg/al













- . -.

a) Bot applicable
b) Bot applicable
e) 1.3S ag/al
d) 1.11 aa/al













-
CBItBU. IfFOBHTIOB
a) 0.25-100 hr after ao ag I?.
Biexponential decline
b) 0.25-100 he after ao aq It plas 2
I Ig/laf elofibrate, oral, starting 3
iik preceding larfario dose.
BletpOBeatlal decline
c) Steady state levels OB 5-10 ag
narfarlB dally
d) steady state lerela oa 5-10 aq
•arfaria dally plat 2 I Iq/day
clofibrate starting > 3 *ks before
varfarlo treataent
c) lad d) different p < 0.05
Healthy 22-35 tr olds, no BBdicatloBS
for 2 preeedlBg irk.
ones; ciiifcwii; BLOOD nism; DRUG
IEfSI»T: I30ITS; COB?1UTITE
ZTIIUTIO'S; BIT1B011TSS; CB1OSIBB
BZrSlEBCE
Biornason, T.D.
Neffla, P.J.
S*ez«y, S.
Blaschke, T.7.
1979
Journal of Ph&raaeoloqy
Bad 5iperli«ntal
Therapeeties
210(31 :316-321









                                                                                        (Birr
-------
Ccaanrlft, 3- (alpb.-a-eeton JHWHITD -1-hraroiT-
2B-1-Be»Toj>Tran-2-on«, *-hT4»X7-
cw-ms-oa
11 308.32, III  161 c
                                                                                  (cortmreo)


IISSB
«78t
Blood.
riant
•7«9
Blood,
plasaa
•7»0
Blood.
plama
»7«1
Blood,
5«m
ZlfOSOSB BO
Inoistliu
Ingest lot
tnqestion
[eat lot
IHtniCll
HBTBOB

Tluoroaetry
t
1

0?°CtSSS ' "*" ' *MI1 ' eilHttl IITOS8»TIOS ( BWE8MCZ
	 - - « ! ! ,'
W ! M J!*£V«"9/il, ' M S>1 •9/>1 ' "' M S(*> «•"«<»« «•>»• 1 Una.!*. l-B.
t b) O-W-1.6 m/al | b) O.W og/il | t\ Dos« as Sf-» cMatlowr I O'lellly, I.».
1 c) 1.3-2.7 njy«l I c) 2.1 a«x.l | c| Dan M ricmlc lixtvr* | l»»j, G.
J I I I«»«ls at vklch tfco sritliesia rate of I 19"»8
' 1 1 protbrosiln caspl** sctlrlty r««che3 | clinical M»r»col<»97
J 1 1 59* of l>re-dos« rit«. »ft«r 1.5 | and Then|wotics
• J 1 •«/»?• | 2 J (2) .-212-217
< 1 1 Kiltkr 21-'1 yr olds. |
'II |
1 I I moss; »iiico»GOLi»tsj BLOOD rtmt; I
I l i ccariBiTin miBiTiois: »BOITS i
....... 1. . . i t 1
1 . i i 	 	 , 	 	
« r aj «.8-2.5 ««/»l | a) lot apflic.bl. | a) Infarla, coatrol qcoqp I | «l«so», C.».
! b? M"!w? 99/ml ' "' *ot »PPlicaHl« I b) lactarU » 80 n/iar faroM»Ite | Horton. B.S.
1 c) «.«-2.2 ng/«l » (:^ »ot applicable | «) iarfarl«, control qcoap II | Eobloaon, D.S.
1 d) 5.7-2.8 «4/«l | j) Hot «pplic«bl« | « lacfacla « 2 aq/Jar boMtantde | 147»
J 1 1 • "4 »* be Man*- after 50 »g {aring | Jontul of Clinical
' 1 1 central period and oa Stb i*j ot I Piariacologr
1 1 1 Mantle alaUlstratloaj. I 18 (2-3) :91-9«
1 t 1 1
1 1 1 lornl 18-2S jr olds, onUeraltT of 1
1 1 | T«rio»t. |
1 1 1 CtOSS; 9106 TIEMPT; TIBBOrT; SHUTS; 1
1 1 1 HCCD niSKl; OIIJ»IIICS; COHPUITTTI |
1 I r f»»if»Tio»sj «rrico»CTi»»js i
1 1 1 1
1 (--. .,...!..- 	 	 1 	
1 ?' !i27S "9/>1 br ' •' 21T * « - 2« 1 a| H-«acfart». 1.5 M/t5 | o«»«lllr. ».».
1 b) 127-35* nj/al hr I »a/«l hr | b) e->arfarla. l.s aVkiJ »0.23 g I 1981
! ?i ?JTJ?? "9/*,1 br ' b> 2*9 * or * 2» ' dis«lflra./aaT | Cli.ieal Pbar.acologr
1 3) 39-117 ag/al ar | «g/»l lr | cl S-warfarln, 0.75 »»/1tg | aad Tatrapeatics
1 1 el 70 » ec - 11 Bg/ail | dl S-«acfaciD, fl.75 afl/kTFOPiot1iToatlacala |
1 1 1 >c«a onl«r tba concantEatloa-tla* |
1 1 I ctt»« data |
I 1 1 B«my 21-30 Tt olds t
1 ' 1 I
1 1 1 Bisnltlraa a*o««at1 ' a| 2'61 * ot " °-35 1 «1 »tfot« lapcam. Mai of Jars 7-11 | Jala. ».
J i*!2"l'J3 m9/'J ' *l/"1 1 ll "«*»4 •aprot«t, ma« of 4ar» I RcXahon, r.s.
c} 2.3*-3.S2 Bj/ail | b) 2.»e * or - 0.»5 | n-2i , sia.tt*cj, J.'.
1 au/al | c] »ft«t aaproien, am a of days 2«-2« I I«Tf. e.
1 c) 2.«0 » or - 0.»7 | steadT-stat* l«T«la (fn« * { 1979
t nu/al | protein-brand) prior to daily dos< of I Clinical Pharaacologr
1 I llqnlficaat affact of Mproitn. | 25(1): 6 1-66
t I ««althr 25-65 rr olds, »t 7».1-«8.5 |
1 1 »9- |
1 1 1
1 i cti8S: imcciGDiins; t
1 | l|TI-T*ni«41TOBT ICIITS; 31COB |
t 1 snm: *oni!; COIPUJUTE i
1 | IT»m«TIO»3 |
_ ..i . ...,.- t ( |
-------
Cauarln, 3-(alpha-aeetonylbrazylJ-4-iirdroxi'->  sodian salt (8 at
2I-1-Se»*opyra»-2-oae, t-hyaroxrO-O-oxo-l-phenylfcatrl)-. aollai  salt (9 CI)
129-OS-S
C19-DKr-Ot.il
ill 331.34
nssn-g

4792
Blood.
plasna














4793
Blood,
plasaa













4794
Blool,
plasaa













tttOSmt BODIB

Ingestioa
















inqestioii













Ingest Ion














imTTIClL
»ST«0»
•PIC
















colorlietry













Colorlnetry














ITJBBIS
or cisss
9















_ .. ._ -
10













1














BUGS

a) 0.25-0. 51 •g'/l
b) 0.16-8.61 »g/l














_
a) 15-2 m/el
b) 15-0.3 wj/sl
c) 14-0.9 ng/el













8-0.9 oq/el














mi 6!»mi irrosBiTiot

) 0.40 nq/1 a) Snokers, after 0.032 if/kg, 1H
b) 0.45 ng/1 I dose, 2 »*
I t) Sablects and dose as In a) , after
1 1 no abstention fron sacking
j Steady state levels. Means
1 elaniflcaatly different.
i
1 Bealthy 19-60 yr olds, sacked at
I least 1 pack of ciqarettva/day.
1
I Itticoaqnlant effects (lengthened
1 protnroebln tines) .
1
1 IBISS: SROKITC: TOBICCOS; BIOOD
| S11S1M COSe»BMIT« ITliniTIOIlS;
1 imcoasntaiis: RnisoLisi: MIYMSS-.
\ TPIOCTUl^IS: iDOlTS
1
a) lot applicable | a) 0 and 1«9 he after 1.5 ag/kg of
b) lot applicable 1 S|-> evantioaorpn
e) lot applicable | t) 0 and 168 he after 1.5 ng/kg of
| t \+) evantlcaorph
| c) 0 ud 168 hr after 1.5 lo/ki) of
1 «,S(»,-) raccnte
| locaal 21-51 yr olds
1 Crothrovtln tine >as highest 48-72 hr
1 fcllovlnii adilnlitratlon. S(-) forn
j above] greatest effect in increasing
1 prothroebtn tine and In decreasing
| ccothrom&in activity.
1
I itiirs: Btooc piisBj; saves
t
I
lot giren I 24 and 144 hr after 1.5 »Vk?>
j tatinated free graph.
j Spiroitolactone, 200 nq/day, 7 flays.
1 had no significant effect on
1 axea-ander-tle-cnrfe of (arfarln.
j lata also for other sablects.
j Healthy snblect. no other drug foe 2
I ao.
1
I Increased prothronbln tiles. Effect
j aiiinlshed by splronolactone-liduced
I aiotesii.
I CSOGS: 1BDG IKTmCTIOR;
| 1ITIC01CH1KTS; BLOOD °L15H1:
| BIOFFTICSj IC01.TS: CC«P»t»TITt
. ,. 1- ....... ... .
BzreiEicz

Bachnann, K.
Shapiro, 8.
Fulton, B.
Carroll, r.T.
SalliTan. T.J.
1979
Clinical PhamacologT
and Therapeutics
25 C3f. 309-3 IS








O'Beilly. 1.1.
1974
cllaical Pharnacology
and Therapeutics
16 (2) : 348-354











0'P.eilly, S.».
1980
Clinical Fbarnacology
and Therapeutics
2712)5198-201











                                                                                        (IEIT  PtSE)
-------
  Ce»MTt», J-f»lpk«-»c«tonTl!>e««rU-«-lLTdla salt  (« CI)
  39-t-ae»opruB-2-oae. •-lrdrffir-3-fS-oio-'-PliejyllMjll-.  xodloa salt  (9  CI)
  129-W-*
  C1«-816-oa.ia
  1« 331.3*
                                                                                        (COITflDED)
1ISSDS

»lt>oj.
plasaa

















srrosvn ROHM



















• MLTTTCH.
HWHOD



















Of C1SE5

9

















8MU

a) 3**-5.2* tag/si
b] 1.03-1.81 aj/ed
c) 1.C2-2.5C a9/*l
a) 0.88-1.22 og/.l
e] 0.79-1.25 »g/Bl

















mi i amtu iiromnoi
1
l
ii| 1.275 oayil I »«/a»T
c) 2.158 «g/il 1 b] 5 eautloeec, » patients, t. S-10
A) 1. 108 ag/al I tj/4»T
•) 0.978 ag/al 1 c) laeeaiie (arfacia. ( patleatx.
1 5.5-12 ag/atr

1 leyda?
| e) s eaa.e timer, • Taluteers, 5
f Steady state lerels
i
1 coinlettiq inticoaqalant taerapf for
1 leep vet* ttieabofls. lo other
I «Slcvtloss. laer 28-70 71.
1
1 Doses fot qood aaticwaalait coatrol
1 qceater Cor t warfarin tbaa far 5
1 vwfarla {• < 0.005).
1
I noes: iiriccicDHns: BIOOB nisai:
l tismiss nisi ersuses; centntstn
- ^
BUEIHCI
Sreckeirid < 1
OCM, 8.
Le«is. S.J.
«ibbcMs, I.
197^
Clinical Pharaacology
and Thecapeetics
tS(*)i«2a-«o













                       B,.lphi-4ia«thTl-  (S CI)
                       I.tlpla-diistkyl-  (« ci|
CW-K1-S
n t^.2«, B» WS c at Ttg *• 85,
                                        c at 20 •• :« (11 foci)
u>
-J
00
flJSOI
«7»«
Bile
















RJTFOSW BOOT
Inject IOB

















imirncu JOSBSI
UTTBOD OF CISS5
ec a) i
b) 1
































jiiss i mi
a) lot applicable 1 a) 0.44 ag/dl
b) (ot applicable I bl 0.57 eg/dl
1






























GJIJHI nroiimo*
a) CY«rdos« death
b) Delta 1>i haaqUe

It- 23 TT old blacks, histories of
-------
CTClokexaaeethvlailae, f.alpha-diaethrl- f« CI)
CvelolexaDeetaiiiaaliie, I.alpha-diaettTl- (9 CI]
101-W-*
CW-MI-I
» 155.28, SP 205 C  tt 760  •• Vg. 92-93  C at 20 •• B«  
-------
      ycoeianeeT' ». alpta-diMt ayl-  (» CI|
     Cjclol>e»aj>eeth»«aai««, ».alpto-4i»etaTl-  (9 CI)
     101-M-S

     B» 155. It, B? 205 C at 760 » Ha, 92-93 C at 20 •• 89  |dl Con)













tISSfl!


•tot
3ria*








1






HB01
Tltreoaa
1 humor
1
1
1
1
1
1
1
I
f
1







TMfosmt BODM t imnmt
f HBTBOB
1
t
!»-)ection
















To -faction

















ac
















ec

















XTRBSS
o? cu:s


i
















•) 3
B) 1











tins'!


tot applicable
















a) 0.05-9.22 aq/dl
b) tot applicable
















	
WM 1 GBinii irroMitios
1
i
1
*.95 ag/41 | cterdose death
1
1 14 TT old black, history of 4m«
1 aktise.
I
1 Basslve deaeeasatloa of alveolar
1 lialnq cells, focal litre-alveolar
1 lesorrhaoe, *ad ante passive
1 congestion. Increased Anabcx of
f aononaclear cells IE aortal «re» of
1 liver.
1
j c»oes: siii: Btooo; nnns: Lira;
l mm TiTPFons sanof; stae JBUSI;
1 C1SI ItrSTOBItS; CORFHlTIfE
I min-novsi THIS
i
\ 	 — -
a| 0.12 ag/dl I a) Orertose deatas
b) 0.05 a?/dl t t) Death tf tai^iag
1
1 11-27 vr old blacks, histories of
1 9tog abuse.
f
1 BypeYaetlvltv. vsconffcioasness death
1
1 caresehTsa coafested. eoBsist»Bev of
1 rotfcec. severe aedical hrpertropiir
1 aad iatisa kfperplasla of the saall
1 aoscalar arteries of the lanqs.
1 llveolar septa Utekaiied, aecoadarr
1 to diffuse f Ibrosis and acote passive
1 cetaestioa.
1 BMSS; BIlBs BI.OOD: KHKEIS; UT»B;
I otri*: VITJICOS BBHOS; !>*rs tsist;
f cisi nsnntst cmtntmis
1 tTHtOlTIOHS: TK1S
1
VI'BKSHCS


DiKlio. T.J.B.
Harriott, J.c.

Joaraal of forensic
Science* 22ni:«2-1Si












Bilalo, T.J.I.
earriatt. J.c.
1977
Joarnal of Forensic
Sciences 22(1) :IS2-15B














                                                                                                                                                                                             OJ
                                                                                                                                                                                             00
                                                                                                                                                                                             o
              oiane,  2,2.»,S.*,8-lieMaetaTl-t.8-dlplienrl-, cia-
HI «2». BJ
TtSSUS
Blool,
»«i»a






riPostrM BOOTB
Icjastion






iHilTtlCH
5BTHOD
as






or cisw
T






»MO!
1.1-5.0 ag/1






SSI I
3.5 mg/1






eiHUl HJO^llTlOl
teaks, *-8 hr after 102 ag. slagle
Jose. Sleiieseatlal decline.
4ea ettfc nrostatle carciaoaa aad
• etasti«es (toae, liver) .
fieneral lipraveseat, relief ef pain
ft 100 iq 3I/dav. la aUe effects.
B»&eS: 9R"S mmpT; CBEHOTWIUPT;
>EOn»15; SIX; 1DOITJ; 5>tDI>; B10OD
STJOf
(EltSXBCE
T libra at. 1.
Striadberg. B.
let a PaaraacDlojiea et
Tosicolojlca 36(S«ppl
lit} 1 139-1*7




-------
D-streptaelie,
37517-28-5
B» 585. 92, BP 203-204 C fsesguihrlntel
TISSH
4803
aloe*.
sens









BIPOSMB ROUTI
Injectloa











IfUTTICll
1BTHOD
BadloaetrT
IniyaatLc










meat
OF C1SSS
t











HIGH
•) lot applicable
bj lot applicable










JEII
a) 21.5 ag/mi
b) 18.3. us/ml









__ .
GKIIHl MTOSIMIOI
•} teak. 1 Ir after 30 «i» IT of 5
ng/*g
t} Teak, 1 be after «» aim It of 5
s«/*g
Total of IS ig/kg/2* »r diTided la 3
loses.

53 TC old leoteai* patient lit*
noraal renal fa net Ion.
csnes: BSUG TBisi?!-. miBioncs;
CHiiO'SE't: THIS; nonaSRS; HOOD
SIBBS
SBrSKBCS
Fraaer, I.G.
Clearr, T.
Fraakel, I.S.
Kohl, S.
Pickering, t.r.
I*"1?
Cli«ical Phactacologr
&nd Therapeatics
26 (5]: 635-640



D-Strvptaaine,
C18-B3«-I»-011
n  •i«.S8
TISSdl
»80»
BlOOi,
sera*


1IPOSTO? EOOfB
Inlectlon


ammcil
HETHOD
aicrobiological


BOBBIE
OT CISSS
16


EtIGI
15. 1-20. » ng/»l
b] 0.7-2.6 aq/al
c) 15.0-22.* «9/«l
d) 0.9-1.8 i?/al


n»
al 17.1 ng/al
b) l.a ocj/al
c) 17.4 ng/il
d) l.a ag/al


C'lISll I»TOBBSIIO« |
!
a) IB, peaks. Peak tUe 1 hr
t) IB, tcovqks at 8 hr
el 20 ain TV. peaks. Peak tiae 30
il«
4) 20 ait IT, tr»«(jha, at 8 lr
10 aqAg/8 hr for 2* dr.
1-1S fr olds, Texas
HTlatQTICS; BLOOD SIB 11; CBHDSU;
tltJS: COXFaMTIR TTSI1HTIOIS;
nmm; imciion; STIRGBET
BEFESEJCE
Tile bar, J.t.
fassiesz, H.
«elso«, J.D.
1980
Joacaal of "ejiatrlcs
««(<): 1981-1 091


                                                                                                                                                                                           CO
Dlbeii«(b,e)oxepla-aelta(11{6in,gaHa)-propTlaalae.
1-?ropaBaaiie, 3-Albat (b,«) oiepln-H («B|-rliaene-I,B-llaetkyl-. hjiSrochloclde
1S2»-2?-»
CW-B21-1-O.C1-E
B1 If. 91, ft IBa-185 c, 189-189 C
                                                                                   8 cl)
                                                                                    CT)
tissm
(80S
Blool,
plana
















IIPOS8SE lOtTTE |
1
Xngestlon


















UllTTIClt
HETBOD
oc/ir


















"OHBIS
or CISES
1


















mot
Sot applicable


















8EII 1
1
2123 >a/»l


















GTimt moiaanoi
Gaak. Data for aixed doKepia-RCl and
aaitrlptTliae-HCl oTerdose also
available.

Ciecdose patient, a?« 23 Tr.

QS; o? 100 asec or ateater en roatine
•C5, »nl one or nore of tie folltnicq
atnoraal Setf tendon r«flei«s.
ventriolar rate of 120 beatc/nin or
greater, riqht handle tranch block.
atrial and ventrlcalar preaatare
ccatractlona, lanctional and
idioventlicalar arrhTthalas,
ttaconsclansness, respiratory support
>«cessacT, ocaad «il seizures, and
acath.
IOVGS; HKTIt'PfESSITE 1CEHTS; BW03
ftisii: IFQG masi: IISSODBI
SEFEKFCB
Erlggs, J.T.
Spilt er, D.G.
Petit, J.«.
Zieglec, T.E.
W77
Animal of the aaerican
Kedlcal association
238|2)s135-13S











-------
 tlqitosll  (» Ct)
 Card- JO fI2) -enolide, 3- ( (0-2,6-aideoxy-lieta-B-ribo-kejtopyeaiiosyl- (1-»)-O-2, 6-dideo*T-»«ta-D-ribo-a«,ropyranosil- (1-« ) -2,6-aideojT-beta-D-rlbo-heiOBTraaosrl) OIT) -1«-hT4roxr-.
 <3b*ta.5beta)-  (9 Ct>
 HI 76S.92, HP 256-257 C  (anhydrons)
TTSSJS
MO*
nooi.
pla»a

ixeosms ROUTE
Ingest Ion

tutrrrcai
BEIHOD
RU

BtUBXB
OF C1SSS
21

EJICE
9.5-1S» »al/l

MUI
_
fot applicable

GEVEB1I, IIFOSUHOI
.
ICter aaititenaice doss or ussiie
overdo 98
Cardiac patients and siBjects ritJt
digltaiin peiBoninq.
»8»»C«; IDIIITS: C»8»TOTISC9HB
tlSMS^S; &1000: BLOOD P1ISB1; DRUG
TBII1JT; C08MB1HTI STSL01ITO1S; I»
tITBO triITSIS
EIFtBESCE
Scherciann, J.B.
Boarloc, B.
1980
Clinical Chttcistrr
26:670-671

Ciqoxla  (8  CT)
C*r4-20(2?l-eni>lll«,  J-((O-Z,«-M4eo*y-b«la-B-ril»-»e»opjraiiosjl-{1-a) -o-2
                       (« CI)
ITI 780.12, IIP about JS5 C  (4ecoip>
IISSB!



• 807
Unlotic
flnl4







«898
Bile












«609
Slool,
fetal










EIPOSU5E ROOT



iBlectioa









Tn-Jecttoa













n1«ctlo«












ililTTICIL
RETBOD


Btl









CC
s«4lo«etry












BT1












»n»BSi
OF C1SES


5









a) t
» 1












a] 3
b) 12











BUSS



lot detectibla -1.5
nq/il








a| fat applicable
b) Wot applicable












a> 0.85 - 3.99 ng/«l
b) 0.20-1.10 nq/il











BE»P | client urosaiTioi
t
1
1
lot applicable I at Selirair, after 0.2 >q IT.
|
1 Italians ql«n digital Is dnrlig
1 Tceqnaicf.
|
I EIOGS: ITlIt; PEEGS1ICT; BLOCS SEBDR:
I imOTIC TIHW. 01BIIICH. COED; TC1ST
1 tisHSfs; DBoe TUJPIPT
i -
l
a| f. l« of dose I 9> « of In -tec ted radioacti-ritr in 50
b) 10. 7< of dose I il after 38 hr. nose, 150 aci
1 31-digoiin-12alph«. >90"= «as
J ai90* «M dlqciin.
1
1 Tatieats vith aeate reoal failure, on
1 faintenance doses.
C
1 cities; ORoe TBXE1PT: nrriBoiiT^s;
1 DBI«»; Bill; C»I»D1; CO>IP»B»TIT-
1 I»JHO»TI01iS; BISB1SSS; SST»BOI,ISI»
1
a) 1.SS * or - 0.35 1 a) < 1 kc after dose. Tallies lower
(SE) ao;/il f tian latenal serai, ? < 0.001
b) 0.55 * or - 0.08 | b| 74-690 tit after lose
(S«) nq/«l I Cord bloal at dellrerr. after 4.2 kg
1 IT to withers.
t
1 Ttaliaas qiT«n digitalis iSncinq
( vreoaaacr.
1
1 cmes; iTitT; PPEGVUCT; Btoco siaon;
1 lesioiic riuio: OHBIUCAI COED; RSIAT
1 tlSFlS^S; DFTO TSEtlCT
1
IinSESC!



Podeletti, 1.
Porciani, H.c.
Sciaooe, G.
1979
International Journal
of Clinical
Pltarfeaeologr and
Bioj>har«acT t7 (2): 32-83


Caolt, n.R.
Sagdan, D.
Haloaey, C.
Ihwd, a.
Twee Wale. s.
1979
Clinical Phariacolo9T
and Therapeutics 25 [S
pt 1):»99-513




•
Padeletti, L.
Porciani, I.e.
Sciaoae, G.
197«
Internatiotial Joarnal
of Clinical
Pharmacology and
BiopliarMcr 17 (2| :82-83





(HIST PUSH
                                                                                                                                                                                              00
-------
Clvoxin  (B CD
Cira-20(22)-«olide, 3-(
(3k«t*,5beti,121>*ta)-  f9 CI)
20830-75-5
-D-clbO"-heiopyranosyl)oi7)-12,1t-dihrar<»r-»
•I 180.92, U a boat 265 C  (ieco«p)
1IS3VS


«10
ood.
plasca















• 811
lass*.












»812
Blool,
vlasaa












• 913
Blood,
sens








BTJOS01B BOTH


lection
nvestian
















ftgestloa













Injection













Injection










IBUTTICat
HETHOD

Ell

















laataoassay













m.













Rla










TO BOSI
0? C1SZS

3

















) 21
b) 11













*













5










11ISE


J.3-7.5 naoles/1
6.3-13.9 naoles/1
0.7-5.1 nnoles/1
7.2-18.8 iaolas/1














] 0.38-1.20 naol/1
b) 5.24-22.C6 nnol/1













a] 3*-0.3 «a/nl
b) 16-0.42 *g/nl













3.18-10.67 ng/nl










mi i etiisit itroiuTioi
1
i
1
%.* naol«s/l t a) teaks, n.5-75 nin after 50 sg
10.5 moles/1 | (oral), joanger patients
2.6 »aoles/l | t) Pea*a. 15 nin after SO »g IT,
11.* naoles/1 I TC«q«r patients
1 c) Beats, 1-a hr after 25 nq (oral).
I tlderlT patents
I a) Peaks, 13 nin after 25 ng IT,
1 elaerlT patients
1
I 6 tenales, aoea 31-61 yr, and a group
| of ! feesles and 2 sales, a-ees 72-91
I jr. til rlth eecdiomegalT aid on
I ctfcer nedications.
1
1 ewes: tett BETJBOIISH; BLOOD ;usi»:
| 111VT DISMSIS
i
1
1 Int applicable | a) Talue* by Ell. tercemt of
b) lot applicable t cto«s-r«icti»ity to dlgltaiin
1 ) Initial •easaranttnt snS 76 hr
b) lot girei 1 alter 15 og/*g IT bolus
I t) initial seasarment and 80 nr
t after 10 eg/kg IT boles and after 8
I lays on 200 *J aainUlne. 2t/day
I T«tlBate9 fro* graph
I
1 IKaltay 21-26 yr olds.
1
t fosltive inotroplc effect of diooxln.
1 ainUished bT gnlnldine.
1
1 DIOGS: nipimit: noon PUSH; MOLTS;
1 KOCB >KTSSmt: VtIS UTEBJCTIOS
1
8.2* ng/nl 1 Calculated 0 hr (peak! ralaes
1 adlastel to b«laa IT lose after *> nin
1 11 of e.8-«.« ag/kg. Biextonential
1 dfdlaa.
1
I 3^-76 yr old patieata, serere renal
1 iapairnent, congestive heart failare.
1
| CH1G5: 1)806 TWE19T; BIOOD SESOII;
| 1ITH.TS; DISUSES
t
lErErarct


Cusack, 3.
Kelly. J-
3*Halley, K.
loel, J.
^aTftn, J.
Horgan, J.
1979
Clinical Pharaacologr
and Therapentics
25 (6): 772-776








Schvrrnau, I. B.
Bcnrdon, B.
1939
Clinical Cheaistry
36J619-671










stelness, I.
laUorff. S.
Bansen, P. 8.
Klaergard, B.
tack, S.
Eqebla.d, B»
1984
clinical Vharaacology
and Therapeutics
27 [61 s7^1— 79S





Koap, J.S.
Jasko, *i.J.
fl.ool, C.B.
Kaali, 9.1.
197?
Cllaical ?baraac
-------
ligoxin (8 CD
Card-20(22)-enoli4e, 3-{(O-2,«-diaeojtj-beta-D-ribo-hexopyranosyl- (1-«)-O-2,«-dideoxy-beta-D-ribo-l«>xo{>yranosyl- (1-»
Ubeta,5bet>,12beta)-  (9 CI)
20830-75-5
C41-H6 4-014
as 780.92, BP about 265 c  (deconp)
                                                                                      (COKTIKHED)
-2,6-dideoxy-beta-D-ribo-heilopyranosyl)oxy)- 12,14-dlhydroxy-,
TISSUE
181*
Blood ,
serai
4815
Blooi,
•era •
4816
Blooi,
am*
4817
Blood,
serai
1818
Urine
EXPOSURE BOO
Ingestion

Tngestian
n -feet Ion
ngestion
IRllRICU.
HETHOD
HI1
BI»

Ell
CC
adioaetry
RUBBER
or CISES
11
a) W
b) 55
c) 8
1
al 6
b) 12
2
HIKES
a) 0.4-1.4 ng/sl
b) 0.4-1.1 ng/sl
c) 0. »-1.3 ng/»l
a) 0.0-0.7 ng/al
b) 0.8-2.3 ng/nl
c) 2.4-4.9 ng/nl
a) Hot applicable
b) lot applicable
c) Hot applicable
) 1.10-4.30 ng/al
) 0.20-0.95 ng/al
(at given
Hat given
lot given
lot given
lot given
Hot given
REIR | GERIB1L IBPOBHiTIOK I BHERERCB
1 1
1 I
a) 0.736 * or - 0.3ft I a) Before bias sappleaent 1 Roods. H.V.
ng/il 1 i) litter 9 days on bran supplement | Ingelfinger. J.I.
b) 0.736 * or - 0.19 j c) 10 days after bran discontinuation I 1979
ng/al 1 22 g bran/day In 2 servings. »o { Clinical Pharaacology
c) 0.74 t or - 0.29 1 significant effect oa digoiin. I aad Therapeatlcs
ng/al 1 I 26(1): 21-23
1 libalatocy residents of I
I rehabilitation center taking digoxlo |
1 > 1 nonth. iges 79-81 yr. veights I
1 99-80 k9
1 | Zaropean Journal of
I 22-94 yr olds on digozln or I Clinical Pharmacology
1 aialtorin. 1 1S:»11-»15
1 1
1 DJOGS: 9KDG TH5B1PT; K1XS1S; BLOOD I
I snai: IEIBT DISEISES i
i i
I i
a) 11. C ng/nl I a) after overdose I Rovett, D.I.
b) 6.0 ng/al I t) ICter charcoal henoperfasion I 1980
c) 1.4 ag/nl 1 c> 3 days later 1 Journal of the laerican
1 I Medical association
1 82 yr old 1 299 (14) r 1558
1 Cizziness, venltlag, atrial I
1 fibrillation I
1 1
1 BRITGSt BLOOD S«D5: HSRODIILTSIS 1
1 1
a) 1.87 » or - 0.36 I a) llthln 1 hr of dose I Padeletti, L.
(3 EJ ng/il 1 b) 75-690 nln after dose I Porclani, B.C.
bl 0.54 « or - 0.07 | it delivery, after 0.2 eg. IT. 1 Scinone, G.
(SE) ag/nl 1 I 1979
1 Italians given digitalis daring I International Journal
1 cr«goancy. 1 of clinical
I I Pharnacology and
1 c«oes; rrnT; PRESWIRC?: BLOOD srann: i fiopdarnacy 17<2):82-S3
1 I9RIOTTC FIOID! OSBIIIC1L COBDJ 9S1ET )
1 DISBISIS; OSOS TB881PV |
i 57.86* of dose 1 a) Total radioactivity. 6 controls I Gaalt, 9.B.
13.4** of dose 1 b) Total radioactivity, 6 patients 1 Sngden. D.
54. 50* of dose I c) Diooxla, 6 controls I Raloney. C.
14.70* of dose 1 d) Digoxin. 6 patients 1 lh«el, n.
3. 36' of dose I •) Total netabolltes. « controls f Tveeddale, !I.
0.79* of dose | f) Total Mtabolitos. « patients 4 1979
1 5 day cnanlatlve eicretlon after 150 I Clinical Pharnacology
1 aCi (« ag) 3B-dlgoxin-12 alpha daring I and Therapeutics 25(5
1 fasted state. 1 pt 1): 499-513
1 1
1 « healthy 24-51 yr olds. « 38-70 yr 1
1 cH patients ilth •iniial renal I
1 function, on henodialysis 3s/**. 1
1 1
1 O'lSS; DBVe TRB»T: K!T1BOLR«S: |
1 0*1*1; Btl?: C1R1D1; CO4P1BITIVE I
1 ITtlTIlTIORS: DISEISES: 1ET1BOIISK |
1 1
                                                                     U)
                                                                     oo
-------
Iplpodophrllotoxln,  4«-deset«rl-, •-r4,C-O-2-thenvlideae-bata-D-glacopyrana«ide)  f»  CI»
!!f JJ' r V : 'i't!? Plli*0,f2;3"2ir 1 •i:2.1?.I01-:S 'S!?' ""**•  S> * • te • »-t«t«»rdro-5- f t-hydroiv-3, 5-di«etho«yphenTl) -»- {(4. 6 - 0- 2-th lenrlse thylene) -beta- D-gluoopTranosTl) oxy-.
f 5R~ (^atLpbAy 3afwt •« DttalPJl41cVDttCB CM*) 11 ~  f 9 CT1
2»7*7-29-2
C32-B32-013-S
HI «5«.7»
TISSVI
Ml*
B1004,
plasaa

4*20
Urine


BirosoK HOOTB
I«1ectloii

iB-Jwrtloa


a mmcii
SETHOD
JtaUontrr

SadioMtET


IUBEH
or c»sis
s

s


illGI
20.96- 39. 1« og/il

lot given


U*l
26.3* ug/mi

««.** * or - 8.2K of
dose


SEIIUI IIFOSK1TIOI
f«»k». 0 hi after 30 «Ln IT of «7
mq/H *, tritium-labelled draq.
Iriexponentlal decline
Patients vith adTanced cancer
tenkopemia. antiaeoplaotie response
in 2 patieitt
CSOSS; DBOG THBEIPT; CHEHOTaiBlPT;
I'OPLisHS; Lttmesii: BLOOD nisu:
nviwi; CEPtBBOspiiit rLoin; nets;
ICOLTS; DISIISIS
CMalatlTe 72 he excretion after 30
•In IT of 67 «q/aq • tritiui labelled
drnq. 78.7t of adnacT radieactiTitr
it eetabolite
Catients Kith advanced cancer
lenkopenia Intineoplaatie response
in 2 patients.
CHUGS: «B5« THZS1PT: CHEHO'BIBIPT;
piopiisis: Ltomii; BLOOD nisii;
nin«: C!PtB»ospi«i TWID: nets;
ItOlTS; BISIISIS
BiriEEFCE
Cceaven, P.J.
alien. L.B.
19751
Clinical Pharnacologr
and Therapeutics
18(2):227-233

Creaven, t.3.
alien, 1.1.
197Sb
Clinical PhanacologT
and Therapentics
18(2):227-233


                                                                                                                                                                                                00
  latcadiol (8 CI)
  lstEa-1.3.S(10)-triene-3,17-diol. (ITbeta)-  (9 CI)
  ?0-28-2
  C18-R2I-02
  « 272.»2. SP 173-179 C
1ISS01
4821
Blool,
plasna








«822
Illk








^tpososs Botrac
Vaginal









vaginal








aialTlICU.
HFTBOD
*ia









ma








B01BJB
OF C1SIS
a) 3
b> 3









a) 3
b) 3








SUE!
a) 30-3000 pg/nl
b) 45-2590 pg/nl









a) 27-1050 pg/nl
b) 40-259 pg/nl








mi i
i
I
&) Hot applicable
b) lot applicable









a) lot applicable
b) lot applicable








Gzmat iiroasaTioi
a) Initial ncasnrenent and 3 hr after
SO «q suppository. 23 hr values
caaged Iron 5C 100 pg/nl
b) Initial neasurenent and 3 hr after
100 ng soppository. 23 hr values
ranged fron 65 400 pg/nl. Istinated
Iron graph.

Bealthv laetating volunteers.
SKSOTDS: BOBHOKM: «LK: LaCiaTIOB;
-------
    Ethane, 2-broao-2-cklor»-1,1.1-triflaoro-
    151-67-7
    C2-B-Br-Cl-F3
    e« 147.31,  BP 50.2 C. 20 C at 2W H »q
TISSUE



M23
Blool











*82«
Breath
























BIPOSOBE SOOT



Inhalation












Inhalation

























aElLYTICIL
BETROD


OC-EC












SC/HS

























IOBBEE
OF CiSSS


•1 10
b) 10











1C

























IMS!



•) 12.55-33.40 ««/•!
bj 16.55-36.95 ag/nl











a) 0.01-0.15 ppa
b) 0.05-0.56 ppa
C) 0.02-0.42 pps
d) 0.07-0.55 pps
e) 0.2-0.5 ppa
f) 4.0-5.0 ppa




















•Ml | GEIEUL I1FOTHTIOI
1
1
I
a) lot given | •) Inestketlsed *ltk » Vain nitrous
b) lot given j oiifl«, 8 I/Bin oxygen and 0.<*
| halothane vapor
| b) iMstkctind >ltm 8 1/ain nitrons
1 oiia«. « 1/iin orr?«n, and 0.*8.32 C, TP «0  aa  -hj  at 19 C
iissm
Ilool



ETPOSOBJ BOOTE
lagestioa



atalYTICll
HZTBOD
Breath analrxer



B0HBZS
OF CISSS
10



iiies
a) Hot given
b) lot given


(Ittt
BS1B
a) 1.0 g/1
b) 0.95 g/1


Pllt)
esiiut rifosHnioi
a) 1 hr after 1 gAq ethanol in
orange i«ice * 1 ^locose capsvle
t) t hr after 200 sq cannabidiol • 1
?/*g etaaaol in oranqe jnice
fitisatel fron graph.
««altiY 21-33 rr oils, *t 52-85 kg.
Broesiaiss, dizziness, relaxation,
f««linqs of dreaainq, abnornal
>«arlng.
tMIIL: IDQIIS: BIOOD: DB06
IITniCTIOl; 05063; XLCOHOtS

BEFESBfCI
Consroe, P.
Carliai, 8.1.
Zulclter, 1. P.
laoeria, L.I.
1979
Psrehopkarnacologr



-------
m»l aleokol (8 Cl)
ttnaaol  (9 CD
St-17-S
C2-BC-0
PI 46.07, I* -117.3 C, BP  71.32 C.  TP BO •• Bg at 19 C
                                                                                       (COBflBDED)
TISSUE

4826
Blood





4827
Blood






















4828
Bloo«






















nrosms Boots

aqestlon






ageatloa























laqestlOB























lurrtrcil
HETBOD







SC























Breath aaalrrer























BOBBSB
or CASES
*






























11























BIBGB

0-430 ag/100 ml






) Bat given
) Bat givea
) Bat given
) Bat given




















•1 0.38-0.06 ng/al
bj 0.3-0.63 ag/al
e) 0.*2-0.88 ag/al






i»














§111

71.1 mg/mi






) 0.44 * or - 0.05
mg/mi
b> 0.30 + or - 0.02
•d/«l
c| 0.»8 « oc - 0.08
•q/«i
4) 0.67 * oc - 0.08
•q/«l
(S.B.)















a) Bot gi*et
b) Bat glTea
c) Bot glraa





















GIBIUL IBrOBBlTIOB

llcakol and pcopoxyphaoe fond.

Co toners' ca««s tro« 3 Calitornla
cea*tl«*.

tivra: osnes: BLOOD: IICOHOLS; CISB
BISTCBI1S; SOICIBB; 9RV6 1BHSB
B«» p«ak. 0.* be after 0.2S q/tq
cttaiol, pcetceatMnt vlth 0.7 aq/kg
Ca carblaide
t) leas neat, 0.75 hr after 0.25 q/k«
• thanol, prvtraatMBt nith placebo
c) Rean peak, O.S kr after 0.5 g/kg
ethaBot, pretreataeat vttli 0.7 *gAg
ca carblaid*
i\ Bea* peak, 0.5 kr after 0.5 g/kg
etkanol, prctreataent >itb placebo
f«ak tlaes estlaateJ fraa qrapk.
tleokelles, ages 23-*« TC. Iraq-free.
noraal cardiovaacclar, kepatic, aad
renal faictioi.
Ithaaol-CB carblilde interactloa
caused Increased bleol aeetaldekrie.
tackrcacdla, fecnaiei ataatolic
tlool pre>8«re, aad decreased etkaael
attabolts* (at 0.5 qAq etkaml
dose) .
tSOSS; D30G IRIBtCTIOB: JOTITS;
I1COBOIIC BE«ni>GBS: BlOOBi
BIlkBOlISH; BBT1B01ITBS; BLOOD
ffZSSIIBB
a) 60 BBd 1BO a IB after O.»1 g/kq.
iBltlal a«aa«reaent, 0.2 aq/al at 20
>la
t| 20 aa4 60 atn after 0.«3 g/kg.
Tlaal •easoreaent. 0.38 aq/Bl at 180
Bla
c) 20 aafl CO aU after 0.85 gAq.
final aeasareaeot, O.S8 mg/mi at 180
BtB
EctiBBted freB graph
fioae alataistered as vodka, tonic.
liae. aad sugar.
Bealtky, PSTcaalogr st««ents IB
Sleden, aqes 20-32 Tr, «t 60-70 kg.
l«»n cOBSvaptloB of pare alcohol, *5
cl/ao.
Core fmliaga of euphoria, lessenlig
of tension at kigkest dose. Bore
aegatln feeliBqs at Lover doses.
Treqaeat coisvaers derlred greater
affective benefits than rare
drinkers.
S»EBK»: BLOOD: PSTCBOT*OPIC DB153:
HPH>T'»»T«L PSYCHOIOGT; ILCOROLS
BBfEBSBCB

Crarey. B.R.
Shav, 9.T.
Bakaaara, G.S.
197*
Journal of Forensic
Sciences 19(11:72-80

Erien, J.r.
Peackey, J.B.
looals, C.I.
Eogers, B.J.
1979
Clinical PharaacologT
and ?kerapeatics
25 («) : as* -463
















Perssoa, L.
sioberg, 1.
STCBSSOB, 5.
19SO
Psrckopkaraaco log T
(8:295-299


















                                                                                                                                                                                               oo
                                                                                                                                                                                               -J
                                                                                         (HIT P1I3E)
-------
Itbyl aleobol (8 en
Itfcanol (9 CI)
Ct-17-f
tt~lt.ll. BP -117.3 C. BP 78.32 C. »P « » «« •*
~«5I5i niosm MOTI «»£"£"
«829
Blool
• 830
Blood
•831
Slooi
• 832
Blool
• 833
BlOOl.
plasna

Ingestlon
Ingest ion
Ingest ion
____ 	
Ingest ion
Injection



. — ~~
	 	 • — •
GC
BMC

19 C
iflBBSB
or cisss
i
i
"
a) 7
b| »
	
a) 6«
b) «7
c) 18
5

ICOBT
	 "~ iiioi
a) lot applicable
b) Bot applicable
Hot given
a) 0.622-1.098 mi/ml
b) 0.672-0.889 ng/»l
a) 120-5*0 sg/il
b) 120-5*0 19/11
c) 1*0-360 ng/dl
•ot given
HOED)
mi
a) a. 98 g/1
b) 0
3«0 ng/al
a) 0.833 » or - 0.162
ma /ml
H 0.793 * or - 0.10S
	
a) 268 * or - 10
b) 272 » or - «3
ng/dl
cj 260 » or - 13
	 __ 	
110 * or - 11 ng/100
•1
— 	 etBHttl IBTOBBlTIoi
t) 16 fcr after dialysis
•Icohol-intoiicated 6 yr old, »t 20.2
ccaatose at 3 fcr, hypotkeEnia. «eak
noise aad unfletectable blood
pceuare, respiratorr arrest.
HCCBOtS; IBSWIlI CTIIDBBBi C»SE
BISTOBTSSS l»T»e«
II yr old pbarsacist, salcide,
overdose of ether drags
BSUCS; BBUO UBS>; SHICIDB:
insn^nn BETBOBS; «••""•!.„.
eiooo; ITTW: aim: KIBBKS; B«»I».
• ICOHOLS
	 — 	 • 	 • —
a) Dose, 0.5 g/tg, 12 hr after 0.7
",/kg ci carblaide. Peak tine, 0.58
t,°Bo»e?'"5'Ig/kg. • kr after 0.7
no/kg ca carbialde. Peak tine 0.«7 «
or - 0.07 kr
lleokolles, »ean age 32 » or - '*• JT
yi. nean body »t 68.7* » or - zz.»J
kg, Canada.
ClIaDa: OISEISZSi BIOOO; DB96
IMEBICTIOB: DSO« TBSB1PI:
CC1MB1TTTE ET»H»*IO»S: HCOHOIIC
IHIBISW: BiTiBoiiss: HETIBOIITES
a) Total saacle
t) Ben
c) «oeea
CllnicallT scber patieatB adaittel at
a kospital emergency roo«
it BITS: sst; BMKJD: onus tpossj
ucosots
peak, 60-75 nin after dose of 0.8
B«althT 22-39 rr olds. Tennessee
Tt»?s»i: icw.TS: BLOOD P«SIU: BFBG
IlTEftkCTtOB; CORPkBlTITE EVklBATIOWS.
	 iSRSEBCE"
ernbbaner. B.B.
schvarz, ».
irckives of Toxicology
•3:317-320
_« —
Qaeree, E.».
Dickson, S.J.
Hissen. »•*.
Panaell. L.K.
1979
joanal of analytical
Toxicology 3:253-255
peacney, J.X.
caglana, S.
Bobinson, G.I.
Re»y, R.
Brian, 3.T.
19B1
clinical Piamacology
and Tkerapevtics
Drso, 1*
Gavaler, J.S.
taa Tfciel, B.H.
19S1
life sciences
28:1053-1056
Desaond, P.T.
Patvardhan. R.T.
Schenker, S.
Roriapa, »•'•
1980
European Journal of
Clinical Phariacology
18:275-278
|IEIT *.»*»
U)
00
00
-------
 Ithyl alcohol  (8  en
 tthanol  (» CI)
 60-17-5
 C2-B6-0
 BS US.07. HP -117.3  C,  BP  78.32 C,  VP 90 »
                                                at 19 C
                                                                                       (COmilVED)

08 3»
Blool ,
•hole




Ingestion



SBTHOD
GC



OF CASES
0



B1BGB
a) 0.2910-0.551 ag/sl
b) 4.05-12. SO ao/ul



»B»B
a) 0.019 ng/nl
b) 8. DO ag/al



GBBMiL IBTOBMTIOH
a) tthanol. lean peaks. Peak tines,
O.B13-O.S27 lir
h) acetaldehyde, lean peaks. Peak
Uses. 0.33-0. 59 hr
Beans of 3 eiperinnts. Ethanol
dose, 0.25 q/kq as 15t solution 12 hr
after 0.7 igAg Ca earbiiide.
Iraq-free alcoholics, ages 00-52 yr,
»t 66.5-96.0 k«. *lth norul
cardiovascular, hepatic, and renal
function.
Tachycardia caused br ethanol and
Ca-carbliide interaction.
CBOGS; alCOROLS; IDHLTS; CM1DI:
BIOOD; OBD6 IBTBBaCTIOH; DBOG SBUSE
BEFBBEBCE
Brian, J.r.
feachey, J.B.
loonis, c.I.
1990
Clinical PharaacologT
and Therapeatics
27(3):»26-K33



IthTlailne, 2-(diphenylnethoiy)-H,B-aiaethyl-  (8 CI)
Ithanailne, 2-(dipheDyl«ethoiy)-H,H-aiBethyl-  (9 CI)
55-73-1
C17-H21-K-0
BS 2^.35. BP 150-185 C at 2.0  n Hg
TISSTJE
81004,










eXPOSBEB BOOTE
Injection
Ingestion










AFilTTICiL
BCTBOD
	
GC
GC/HS










BOB BBS
OF CiSBS











BUGS
a) 99-196 ng/«l
b) 37-83 ng/al










HBAS
a) 100 ng/nl
b) 55 ng/al
SE









GEIZBU IHPOBfliTIOB
a) Peaks, after SO eg IT. Continuous
decline froa 1st saaple at 1 hr.
Bean of 37 ng/al at 8 hr
b) Peaks, 2-3 hr after SO ng, oral.
(lean of 22 ng/nl at 8 hr.
Bealthy 22-33 yr olds, light neal
before All dose.
sedation and antihistaBine effects
positively correlated vith plasia
level. Intlhistanlne effect but no
sedation at 25-50 ng/nl.
CHUGS: SSMtlVBS; » DOITS; BIOOD
Fitsni: HEiPcioGic HIIIIFESTITTOBS
1ETEBEBCE
Carrnthers, S.G.
shoeaan, D.R.
Hignite, C.Z.
•zarnoff. D.I.
1978
Clinical Pharnacoloqy
and Therapeutics
23(0): 375-392






                                                                                                                                                                                           oo
 clic acid (8 CI)
 -Glntaalc acid. B- (»-(((2-a>ino-1,O-dlhydro-O-ojo-S-pterialnyl)lethyl)aiino)benioyl)- (9 CI)

 19-B19-H7-0«

0836











EIPOSUBE POOtB
Ingestion











•HalyTICiL
1BTHOD












RDBBH
or cisEs
40












Bot given










(BUT
HE1H
138.9 * or - 11.5
lu/nl









PtOE)
GEBSBii iirosntnov
Prior t-> follc acid treatment. Ifter
3 X 10 iq per day for 30 days, levels
increased about 5 fold.

lorao- and cligosperaic patients.

Bo change in spern count, V gotile
item, or ONI content per cell after
folic acid treataent.
IS91EL; 9B1GS; DBOG THBSJPT;
TiT«ni
-------
   To lie Kit  (8 CT)

           c *CM'
   CH-S1»-»7-C6
   II M1.»0
                                                                                     - i*
                                                                                     (Commit)
tissue
«837
Blood.
sene








•838










Exrosms loot
Iioestion








I B 90S t 100










IfilTTXCaU
METHOD
Bicroblological



















•HIBES
OF C1SBS
<








«o










t»ei
a) 106-261 «g/il
b) 7«-m eg/ml
c) 300- « 80 ng/.l
d) 170-330 ng/nl








lot given










01*1
l) 167 ng/el
b) 122 B9/»l
C) «1« «g/ll
d) 263 ng/sl








•«.S « or - 7.1 Itl/Bl










eiinit immuTio*
•I Predinlrsls, 1 ng/dnr dose
b) FostaialTsis, 1 iq^Aay dose
c) PraillslTSis. S loylaT dose
4) PostdlalMis, S «a/aay dow
Cialysis stittcd 1 kr «ft«r do««.
D«clt»« during dialysis was 26-53?

Stable ancphrlc pattats aailtained
tj h«*o41alT»is 6 hi. 3I/*k.
CB06S; D90S TBBI1PT; BIOOD SISOH;
CISHSBS; COW1SJT1TE ETltNTIOIS;
TIT1HI1S
~
Prior to folic acid treataent. Jft«r
3 T 10 >?/daT for 30 days, lerels
ion about 3 fold.

lorao- and oligospetaic pattats.

lo chaa
-------
Cntiiicla
1»03-«6-3
iMCt COIPOSXTXOI BIKtOVI 0* BIDITElglllD
It 102-IOf C
                                                                                     (COIYIIOKD)

Mil
senn


Saspirtto
secretion


Urine

UOS9U sootB
Peritoneal


iBlectloa
Ingest ion
Inhalation


Injection
lagestlon

iMLTTiciL
RRBOD
m





Ucrobiologlcal

lOHBH
or cisis
7


8




11MS
3.9-l.a ng/nl


a) ». 6-42.0 ag/sl
b) 13.6-22.0 ag/el
c) aao-12 aq/nl
4) 0.30-1. M ug/nl


•) 12.6-95.8 ag/nl
b) lot given

mi
lot given


a) 22.0 ng/nl
b) 17. » nq/al
c) lot applicable
4) lot applicable


a) 35.7 ag/Bl
b) 19.3 ag/sl

6BIM1L HFOMHXOI
6 and as br after too sg dose added
to 6 kr, 2 liter peritoneal dialvsate
{1.5< deitrose). Initial
aeasareneBt, 1.7 09/1! at 1 kr
Binge of aaans
Chronic renal failure patients
undergoing continuous anbvlatory
ceritonenl dialysis, 27-67 yr old, vt
57.3-89.3 kg.
IIDin DISE1S1S: BLOOD SBKOK:
miBiotics; DS«C Ttmipi;
HlSTBlUBltT IR80DS
a) Traekeal aspirate, 1 hr after »0
nq, aerosol
B) spatas indvxrea by tracheal
aspiration. 1 hr after *0 sg, aerosol
c) Bronchial secretions, 0.5 and 6 hr
scans after 2 eqAg, eadotrackeally
n Bronckial secretlOBS, O.S and 1 kr
Mans after 2 nq/kg, II. Final
aeaaorenent, O.S aq/sl at C hr. c)
and d) estisated fron graph.
• tracheotonized 51-63 yr olds, la
searosargieal nait and « adults vhose
tronchlal secretions were tested for
aeoplastic cells. Belgian.
BtieiOl; 1B011S; BIOOD; B1OOB SnOH;
•ITIBIOTICSi nSPIllTOBT SBCBRIOIS
a) 0-C hr levels after 2 nq/kg HI
b) 0-< br levels after 2 nq/kg,
endotracbeally
51-63 vr olds, hospitalized for
cranial traaaa, tracheotoaized.
IIlGItll; 1DIHTS: BLOOD; BLOOt SSSOU;
1RIBIOTICS; IESPIRHOP.y SZCCRIO1S
CEFEtEICB
Pancorbo, S.
Conty, c.
1*81
Intinicrobial igeats
and Ckesotherapy


Odio, t.
Tan Laer, !.
Klastersky, J.
1975
Journal of clinical
Fharnacology 15:518-524


Odio, W.
Tan Laer, !.
Klastersky, J.
1975
Joanal of clinical
Pharnacology 15:518-52*

-------
   Glocttol.  1,4:3.«-dianhvdro-, dinitrate.  0* (« CI)
   t-eioeitol,  l.ttS.t-dianhrdro-. dinitrate (9 CI)
   81-33-2
   C«-B8-»2-08
   B» 236.1«, IF 70 C
TISSUE

48**
Blood,
serua




















•8*5
Brine











El POSHES BOUT

Snbllngnal






















Ingestion












iBiinieii
HETHOD
SC






















Badionetry












BOBBSS
OF CISBS
10






















2












I1BGB

a) Bot givei
b) Rot given
c) Bot given




















8-97* of dose












BBil | SElISal IB'OBBITIOB
J
1
a) 17.9 * or - 3. 1 I a) after 5 ig. Peak time 10.0 » or
ng/nl | 1.8 ein
b) 9.0 * or - 0.8 | b) 2-isosorbide dinitrate
na/il I (netabollte) after 5 eg isosorblde
c) 38.* * or - 3.* I dinitrate. Peak tine 52. 1 « or - 9.
ng/nl 1 sin
s« | c) S-lsosorblde diaitrate
I detabolite) after 5 ig isosorbid*
| dinitrate. Peak tine tl.t » or -
I 1«.« atn
| leaks
I
I Bealthv volinteers. Federal Republic
1 of Gcriaiv
1
1 Beadache, nausea, light-beadednesa.
1 decrease in Hood pressure, increase
I In neart rate. Severe hypotension
j and reversible bradvcarlla in 3
1
| G1P.MBT: AUDITS ; BiOOD SEBDB: DTOGS:
I innBOLisH; aETiBoixras
1
Bot applicable I 4-120 hr emulative excretion after 5
I ig UC- labelled drug. Ixcretioa 92*
I coiplete by »8 hr. 80* excreted as
I colar naterial. Vncliaaged drag
I detected oily in 0-3 hr ncines, as
1 <1* of dose. Boat polar nateriel vas
1 conjugated isosorbide.
1
1 Volunteers with narnal renal and
I hepatic function.
1
I OBOGS: HETIBOIISB: IRlBOimS;
I OB HE: ADMITS
SEFEBEBCZ

Sporl-Badnn, S.
tetxien, G.
Kantian, B.
liede, T.
Ibsbagen, D.
1980
European Journal of
Clinical Pharnacology
18:237-2**














Down, ».B.
Chasseand. i.T.
Groady, E.K.
197*
Journal of
Pharmaceutical Sciences
63f7):1W7-11»9






                                                                                                                                                                                            UJ
                                                                                                                                                                                            VD
                                                                                                                                                                                            ro
Glatanic acid, »-(P-(( (2,n-aiaaino-«-pteriSinTl)net»rl)»»ino)beiixoTl)-. L- (8 CI)
t-eietaaic acid, »-|t- (((2,«-diaaino-«-pteriiii>7l)BetliTl)aaino)benzorl) - (9 CI)
C19-H20-B8-OS
HI *«0.(3
HSS9B

• 9n$
Blool,
serai


















FTSOsms Botrri

In -feet ion




















illlTTICJL
fIBTBOB
J.._L_J..L 	 _, 	 j_ _| 	 ll_ !!_.!_!





















I
HOB SIB
OF CISBS

12




















MBSB

a| 10{E-aj-1.SI10(B-7)
noles/1
b) Bot given
c) lot given
d) Bot given
e) Bot given















RE1S | GBI1HI IBP01B1TT.OB
1
t
a) lot applicable I a) Baiqe 0 and 2* hr after
b) 3. 6 » or - | aaspectfiel dose. Biexponential
2.0X10(E-6) noles/1 | eliilnation c| Bephrotoxlc
c) 1.6 » or - 1 c) Bonvephrotoxle
1.0:iO(£-6) noles/1 | d) Systeiicallv toxic
d) 3.2 * or - | e) Bontoxlc
t.8I10(E-6) noles/1 ( t)-e) toiicity after 250-350 ig/sq •
e) 1.6 * or - I followed by leocovorla rescue
1.2X10(E-<) noles/1 I
I 2?-69 vr olds with ndvaaced
j aetastases.
1
I lanoea aad/oi vositing, aococitis.
1 Itukocrtopenia. platelet count
I suppression, nephrotoxicitv.
t lyelosappression, elevated serai
I creatlntne.
1
I DRUGS'! ORTG IBSBaPT: SEOPLISHS; BLOOD
t SIKH^; aOOLTS; aBHOnTIB COBPQVBOS;
\ CBMOTS^llPt
IB'EBEBCZ

Glode, l.B.
Fitnan. S.S.
Fnsainoer, f.P.
Posowsky, A.
Papathanasopoalos. B.
frei, T.., Ill
1979
Cancer 'Sesearch
39:3707-371*












-------
C20-R22-I8-05
il 454.46. gP 185 C (decoBp)
f ISSOB

Mood.
plasn






4848
Blood.
seres







-
4849
Cecebrosp
Inal







18-50
Orine




	

EXfOSOR ROUTE

Injection






Talectlon








injection







Tn lection







HBTBOD
BPIC
tnxy.atic






RH








m







HPLC







BDBB31
OF C1SES
3






3








3







4




.


81(01
a) 0.6X19(1-3) -
0.5X10(E-6) soles/1
b) 0.8X10(B-3) -
1X10 O-C| soles/1
c) 1X10 (S-4| -
0.8X10 (S-51 coles/1






a) 8X10|E-4t-9X1»(E-8)
•oles/1
b| SX10(B-4) -3X10(1-8)
aoles/1








•oles/1
b| 4X10(B-6)-7X10(B-8)
aoles/1







at 6,986-16,633 ag
b) 230-984 ag







RBIB
at lot givei
b) lot givea
c) lot given






at lot given
b) lot given
_







a| lot given
b) not given







») 10,952 + or - 4079
b) 486.5 * or - 337.9
aq







GBIEUL IBPOIMTIOI
at 6 aid 48 kr after 6 br IT, HPLC
c| 6 aid 48 kr after 6 kr IT, eazvse
Inhibition aetfcod
e) Metabolite. 7-Hyaraxynetkotrexate.
12 and 48 kr efter 6 br IT, BPIC
aetkoa
Cose, 290 >g/kq
latiaated ft on qrapb
«-22 yr old osteosarcona patients
CCRPHHITE miOlTIOBS:
CBITOTRBllPT; VBRBO ST1TIS; BOW
tISIlSTC; BBOVLaSSS; 910OD PUSH
a| with proteaecid, 1.7 g/sq s
orally, in 4 doses/day
bl lithont probeaecid
Talaes are 1-120 hr levels alter 15
•In IT of 3.0 q/sq n. Coatlnnoas
b {exponential aecllae. Data also for
constant infusion.
Cancer oatients. ages 20, 24, and 47
Ti.
lo toxic effects.
tines; t»us nrrmctioi:
CRIROmSlPI; »K>«l»SBS: BLOOD SBBUfl:
ciREStostiiiL riniB: SJTIBOIISII:
IID1TS! CB1IOREI
a) Bith proteaecia. 1.7 q/sq • orally
in 4 ao«es/diT
b) without fcobenecid
24-72 kr qeonetrie aeaas after 3.0
g/sg B IT over 15 aln. Large
standard deviations. Data also for
continuous In fa 3 ion.
Cancer natieats, ages 20, 24, ana 47
lo toxic effects.
HBSS; SRDG WTESJCTIO!!;
CBIHOTHMIPT; KOPlaSHS; BIOOD STSV1;
CtlZBROSPTftU. n,BIB; ICKlBCtlSH;
1B1ITS; cmiE8»W
a) (letkotrexate *
7-hTaroxy-sethotrexate t
2 . 4-aianino-R (1 0) -aethylpterolc acid
b) 2,4-Pla«ino-1l(10) -aethvlpterolc
acid
0-48 hr cneqlative excretions a'ter
ttart of >50 aq/kq, «-hr IT. Total
aeses 11.5-22.1 q.
Cancer patients
CF1GS: CHIHOTH'El'T: IT Sim ;
IIUBOLItrS; BBJS3SB1HIIT HETHODS;
ITOPLiSIS; ElStlSZS
——"——•

IBTEEEICB
Bovell. S.K.
•anq, T.-B.
Rosoya. B.
Satov. D.v.
1«80
Clinical Chenistry
26:734-737






Bovell. S.8.
Olskea. B.I.
Rice, J.I.
1979
Clinical Vharsacology
and Therapeutics
26 (S) :641-«««







Bovell, S.B.
Olshen, B.».
Pice, J.I.
1979
Clinical Phanacology
and Therapeatics
26l5):*41-6»6
-





Donekover, B.C.
Rande, K.E.
DraXe, J.c.
Cbabner, B.I.
1974
Clinical Pharaacoloqy
an4 Tkerapeatlcs
2f(1):53-72





                                                                                                                                                                                        OJ
                                                                                                                                                                                        VO
-------
6014
TMO-57-5
l*f 19«.»«5
iissSi
»8S1
BlOOd.
plasia
91oo4.
••ran
Betas
irla«

, HP W«*.7C C. V
"EXPOSOM soots
Injcetlo.
I.tactlot
I.loctlo.
Tajoctloa

p 2700 C. 1* 1 •• •«
	 auimcu
us
US
us
MS

at 186* C. 1
*'siao»i
aim
_— — — 	 • 	 " ~~~~~
810 .4 e«.alatl»« 4os« °*Bj.«»atol4 patlnt
Llf«-thr«at«.U9 tfcro.boeTtop.ala.
»«COT«CT att«r pr^alsoa* ana
«l.«rcaprol tkorapT-
SCIB: BSISOIIIBBBT nmoosi »«!"«!?"
mBBT-IS: SFMl POTSOBTW6; tISMSIS:
J"«sT I" »»«»5 BWOB SraOT:
BMM
- 	
a) 1st 2« kr
Pa*l««t« •«» cfc.taatol4 arthritis.
•fan aq« 57.1 • or - 11.3 Tr.
sen: WHS: «»«"»'"» "'"ISi'
etoeo s^soii: ITKBI: nets: BI«M»I
tmnBOLtsi: aDOtTS

— — 	 UTBBMCB
ClUlc.1 Pb«r»acolo9T
and Tb«rap««tics
15|»»s35»-3«0
pal.«r, »i6.
1979
JOBTBB! of »nalrtl«al
Toilcology 3:2«2-2a5
Crennan, D.B.
pal.er. D.G.
1979 , ,
aoacnal ot inalytical
Tolieologr 352B2-2B5
Cll.le.1 Pkar.acol09T
an 4 Tknapevties
«{t)!35a-3«0

to
-------
C10-S16-I6-S
If 252.38


Biooa,
plasma



Xageatlo*


SBTBOB
	 	 	 __
BPIC


OF CISES
6


MISS
	
a) 0.02-O.S og/al
b) 0.3-1.5 ag/al


BUI
a) tot givea
b) lot glTen


GEIElll IfPOlBaTXOi ""
a) 60 aia after 200 eg dose
t) 300 ain after 200 ag dose
Istiaated froa qrapk
Realthr 2»-3fl yr old*. wt 65-78 kg
50* Inhibition of gastric acid
secretion with aean plasaa level of
0.78 ag/al.
IC11TS; B100T PL1SI1; IBTOIOMC
noes; nines


IEFESMCE
Gagler. 8.
Pocks, e.
Diekaann, B.
19S1
clinical Paaraacologr
and Therapeutics
29(6)s7*a-7»8

        lazolidiaedione.

C8-BC-I«-05
n 238.16. II 270-272 C  (deconp)
                                                                    CT)


*85*
plasaa



-
4857





Uttae






lalectloa
Ingest ton




Inoastioa





laqestloa





«TBOD
me




Colorleetrj





•PIC





OF cms





6





a) c
b) 6





UIGE
a) 51.9-75.5 ag/al aia
b) 56.8-76.1 no/al aia
c) 59.5-75.5 og/al ain



	
a) 10.59-34.58% of dose
b) 3.67-U.13K of dose





a) 26-320 ag/al
b) 18-8* ag/al





Bill
~
a) 63.2 » or - 10.3
ng/al ain
b) 68.0 4 or - 6.6
c) 66.6 « or - 6.5
ag/al ain



a) 22.2* * or - 8.*3t
of dose
b) 9.52 4 or - 3.69*
of dose





a) 132 » or - 116
nq/al
b) 59 * or - 23 og/nl





6111111 IIFOllaTIOi 	
a) Oral, fasting. 50 ag dose
r) Oral. «ltk food, 40 ag dose
c) IT, 47.0-56.0 Bin infusion.
area ender concentration/tine carre
data
Healthy 25-35 yr olds, wt S2-80 kq.
itniTS; BIOOD PUSH; DBDGS-. osi»-;
cntBOUKS
— 	 	 	
a) 100 ag dose. Peek at 3.0 » or -
1.6* ar
•1 100 ng wltk "> g B
-------
Bydantoln. 5,5-diphenyl-  (8 CI|
2.4-IniaazoUalnedione, 5.5-4iphenyl-  (9  CI)
57-41-0
C.H-B12-112-02
B« 252.28, 8P 295-298 C
TlSSUg

4B59
Blood,
plasma














4860
91001.
plasta










4W1
BlooJ,
plasna








48S2
B lool.
plasia







(863
Blood,
plassa










ITWSHBS HOOTS

Tnqestion
















Ingestion












Ingestion




















1 11 lection










-

mumcu
BETBOB
SS
















BM.C
Badionetry











sc










ColorinetrT








,__,
colorivetry










-

B0BB8B
or CISBS
7
















2












a) 70
b) 39








.
10









12












BABGB

a) 1.13-1.11 nq/»l
b) 0.013-0.112 ag/al
c) 0.56-7.31 ng/«l
9) 1. OS- 3. 03 nq/ol
e) 0.011-0.053 ug/sl
f) 0.22-0,72 ag/il











a) 2.16-2.46 ug/nl
b) 0.0429-0.0554 og/«l
C) 0.560-0.602 nq/ll










a) Rot givofl
b) lot given








.
a) 0-32.5 ug/ll
b) 0-29.0 og/ul








a) 7-0.4 ag/al
111 4-0.38 ug/ol








/
-
(BUT
8E»S

a) Hot giTan
b) trot glren
O Hot given
d) lot given
ej Bat given
f) dot given











a) 2.31 ug/il
b) 0.0492 ag/ml
c) 0. 983 ll!J/»l










a) 14.134 » or -
10.987 no/ml
b( 12.90 > or - 9.152
lld/Bl







a) 15.4 »g/»l
b) Not given








a) sot applicable
b) not applicable










P»GF)
G1BSB11 IBFOBH1TTOB

a) pheaTtoinf oreaics
b) Tree 4-OB Ktabolite, uteiica
e) Conlngated 1-OH letabollte.
nteaics
d) Pkenrtoln, controls
e) nee 4-OB n«tabollt«, controls
f) Conjugated 4-OB «etabolite3.
controls (0-7 lays)
0-11 flays, 6 hr after 0.1 q/day, an
dose.
28-67 yt olda vith chronic renal
failure, nealtby 28-37 vr olds.
D11GS; DISD1SKS; HmcOHVOlSitlTS;
E100D ?t>5K>t OEIBE; COIIPAEHTHE
tVSimTIOBS; KIDIBT DISEaSIS:
BITaBOlISK; XBIJBOIITBS; SSEDBB;
I CUTS
,
a) Malta, at 1 hr, dlphenvlhTAantlon
c) Peats, at 0.5 and 6 hr.
p-bTdrotTphenyl vetaholite
c) Pe»*3, st 12 hr, p-hTdroiyphenTl
letabollte as qlocnronlde conlagate
Cose, 80.8 nq 14-c- labelled
dlphenTlhrdantoin acid.

B«althy 24 and 32 Tr olds, tasted
c«(ore and after dose.
ICOlTSi BtOOd PllSlla:
HTICOHVDLSIirtS; DBTOS; BBTiHOllSB :
KtTiBOHTRS
a) Bales, 2-4 hr after 5.68 • or -
6.24 nq/Vg
It Tenales, 2-4 hr after 4.37 » or -
2.90 iq/kq

Patients on nalntenance doses for
seizures.

IflTCOIVtlLSaBTS: DBBS THEBIPI: BLOOD
V11SHI; SET; DRBG IRT5BHCTIOB;
tlPBCHTlBTDanOIlS
.
a) Deternined by
alcrospectrofhotonetrie nethod. (lean
ditference between duplicate
dgternlnations, 1.0 aq/nl
t) fy a Mcro-nethod at a pabllc
hospital laboratory, 12 specinens
lean difference between nethols, 1.3
oq/il.
DBH6S; aBTTCCBVnLSanS; HKtSBfERKT
BFtBODS; B10QD PlUSBa
a) 10 nln and 72 hr after 250 ng IT
at K nq/iln. Blaiponential decline
b) 15 an] 120 hr after SOO >g IB In 4
sites. Initial seasnrenent, 1.6
oq/nl. tstlBated froe qraph.

Sealthv 20-31 ft olds nt. 57.9-79.5
*g.

DBOI55; KBTtCOBTni.SaB1S: BIOOO PtiSIU;
HOtTS; OBIBI: CONPaBITITI
fvumnoBs: RITUOIISB

BE?E«EBCE

Borqa, 0.
Boppel. c.
odar-cederlof, I.
Garle, 9.
1979
clinical Pharmacology
and Therapeutics
26(3) : 306-314








.
Albert, K.s.
Ralinark. a.f..
Saknan, E.
«e Idler, D.J.
Vaqner, J.s.
1974
Besearch Costtanicat'ions
In Cheslcal Pathology
and Pharnacology
9(3)!4«3-4«9



Schaeffer, D.J.
Janardao, K.G.
Soiani, S.
-------
 BTdantoiB,  5,5-dlpheBjrl- (I CIt
                                     - c»
C15-B12-»2-02
II 252.26. DP 295-29* C
                                                                                      (COITIIVED)


»86»
Blood,
plasaa










•865
Blood.
plasaa









• 866
Blood,
plassa










1867
11004,






— 	


Injection
Ingestlon











Inqestion









Injection










Infection








alaLRTCll
HBTBOD
Colorlsetry











GC









GC










GC
Badlonetry






- - 	
lOHEES
or cisis
i











6









1










1






„ 	 .
MICE
108.5-0 og/al











a) 9.0-3.9 ug/al
b) 7.6-3.3 nq/Bl









a) 11. 9-10. « og/al
b) 11.1-10.3 Bg/al










9.5-3.75 BBOles/1







SHI
lot applicable











a) lot given
b| lot given









a) lot applicable
b) lot applicable










lot applicable







(MIT P.GB)
GEIIB1L IirOSBlTIOI
2« hr aad 11 days after last dose of
. Soae data estiaated froa
graphs.
tealthy 22-32 yr olds, fasted 8 kr
before-3 hr after pheaytoin .
ttoes; BIOOD FUS«I: JDTLTS:
CC1PIB»TITE EVllOUIOIS
a) Entering heaodialyzer
t) leaving heeodialyzec
Talves are froa 90-330 Bin of
heaodialysis starting 12 hr after a
fourth daily dose of 900 >g 17. S3.6
•9 total drug in dlalysate after 9
hr. 31-38« of plasaa drag
Frotein-boand.

21 yr old unite nale with history of
renal failure, essentially annric.
hospitalized for renal transplant.
DIMS; DHOG T.BEH1PT; BIOOD PLISHlJ
1COLTS; DISUSES; imCOIVOLElIITS
«-20 hr after 10 ain It, 100.21 »g,
labelled dose. IT infasioa of 100
•g. para-hydrozyphenyl aetabollte
over 1« hr.
Healthy snblect. nonnedicated >« «k.
MUGS; RET1EOLISR; (miBOHTES;
EltT«E3; 4DOLTS; H1IITED KIBGEOB;
HOOD BtaSHl: alTICOITOLSIITS; OTOG
IITmciIOl
— — — — — ______ ___ — _
" BEnancl
Praltt, l.».
Zsiren, G.T.
Patterson. J.B.
Dayton, P.e.
Cook, c.E.
•all. B.E.
1975
Clinical Fharaacology
and Therapeutics
18(H:112-120






Fraser, D.G.
ladien, T.H

Sotherland^ E.v.
1980
Clinical Pbanacology
and Therapeutics
27 (Z): 165-169






Idler, D.S.
Hart la, t.
Gaabertoglio, J.G.
Tozer, T.H.
$pire, j-p.
1975
Cllalcal Pharnacology
aa« Therapeutics
18(1):65-69





Peracca. E.
Bakkl, X
Bichens. ».
1978
Clinical Pharaacology
and Therapeutics
2«(1).»6-51



	 _. 	 „
                                                                                                                                                                                            CO
-------
Bydaatola. S.S-4i»heayl-  (8 CD
2,*-I*llexoUdI.M41oM.
C 15-112-12-02
fl 252.26. «r 255-2*8 C
TISSUB EIPOSOBB BOOTE | 1BU.TTIC1I
1 BVTBOD
1
1
»i68 lagestion OC/iS
Blood.
Beraa


1
1
1
1 |
1

«IC9 f lagestiaa BI1
Blooi. 1
sent I
1
1
1 1
1 1
1





•870
Saliva





f

1
1
1 «871



ITOBBSB
OF CISSS


W










7










MICE U1B | EBIBUI, nWIBMIOI
1
1
1
a) O.i-23.2 *g/l a) Vat «i*ea I t) taaae of 'peaks
b) 0.33-22 ao/1 fe| fat give* 1 »( Baaea of *eaa«
1 C, *, 8. <>d 12 kr after doses
1 raiflaa trot 4,0-17.9 ag/kg/day.
1
1 IpproxiMtvly 2 ao-20 yr olds
I lospitalizad for seinres.
1 itnss; DIHC IBEUPT: ciiiDBEf;
( TiPirtS; imooirOLSutS: BLOOB smrn
i
1
a) 9-22 "iolos/1 a) fat given ( a) 2* kr after 300 a?
b) O.SB-3.C aioles/1 b| Bat giren 1 t) 72 kr attar 300 a*
I 1550 aa aspitla at 72 hr loirered
1 plteavtoin by 2T.*t otec 2 hr values.
j fitleated free ?rapk.
1
1 lealtkv 23-3« yr olds, Tt 50-80 kg.
1
I tioss: Dene trtitictioi: BEOOD snoa:
I IBBITS: SHItl: tniCOBTOlSlBTS;
I iBuetstcs: JUIPTIIIICS; BIB
I I fflllBB! VRiBOUSB
1 -------- J
laoestio* Bit 7 a] 0.«8-l. i vaoleayl a} Vot given I a) 2» he after 300 eq
1 b| 0.055-0.18 i*ol«a/l b) »ot aivea I k) 72 kr after 300 •«
j I Eatieated frca grapk
1 1
1 Sealtky 23-36 re olds, »t 50-80 kg.
1 1
1 i tnss; one insBicnoB; BIOOB SEBIIB:
I I jstJiTS; siiiri: i»ricoiTtn.s»rrs;
| I MllGFSICS: imPTBETICS; »U
1 THIUV: miMtXSI
1

XaeestioD
1 Urins |
1 1
1 1
1 1
1 1
1
1
1
•
1




«872
Vriae














lafectioa











BS « a) O.M-1.2JT of lose a) 0.92* ot dase | a) tkeeytoia














sc











b) 0.78-2.01 of dose
c) S2-9VX af dose












12




















_____

a) 156. 1-22«.3 •<_
b) 183. t-«25.3 aq









_ .
b) l.ac of lose I b| Ree <-OB letabollte, e)
lETEIEtCE



DOdCOB, f.S.
1990
Clinical Pkaraacology
and T*erapea.tic9
27(5)s70»-7«7






Paiton, J.I.
1980
Cllaical Phanacology
and Rierapeatics
27 (2fs 170-178








taiton, J.».
i9»a
Clialcal Pharaacology
aad Tkerapeatics
27 (2>! 170-178




. .

orga, O.
ippel. c.
c) 77« of doae | Conjugated a-OB aetabolite f odar-cederlof, I.
1 steady state artaary recovery fraa t Carle, B.
1 12-kr daytiae collections. Beaas af r t979
t * days after 0.1 agxdar, IB dos*.
1
1 Bealtkr 28-37 yr olds.
i
I cues; DISUSE! kiriconnisuts;
i ficco tttsii; OB in; coirutiraTt
t ETltnilOBS; KDIBT DISS15B5:
1 BttlBOLISIJ UTkBOlITSS; S»IEEWJ
1 ItfllTS
1
a) 187.« >q | a) 2S8 aa IT at 25 aq/ala
b) 3*1.8 *g I t| 509 a? Tlf ia » sites
1 120-kr eaealatlve excretloaa of
1 9-p— hydroxypbeayl-5-pkeaylkydafttoin.
1
1 Icalttiy SO- 31 yr olis et. 57.9-79.5
1 *fl.

1 ISMS; irricoaTJisins: BLOOD HaSRt;
i HOLTS; ntm: ccwmtiTE
1 ITIM1TTOHS; BnkBOlISfl
1
Cliaical ?haraacology
and nerapeatiea
2«f3|:30«-31*







Kosteabaader, B.B.
Bapp, t.P.
RcSovera. J.P.
roster. T.S.
Terrier, 0.6.
Blacker. B.B.
guloa. B.C.
riakel. l.«.
1*75
Clialcal Fharaacolo^y
ana Ttenpeatics
18 (») j »»9-«56
































VO
00
































-------
Bydaatola, 5,S-dipl«Byl-  (8 CI)
2.«-Isl4azolidlMdione. 5.5-dlphenrl-  K CI)
57-«1-0
C1S-B12-B2-02
if 252.26, » 295-2*8 C
                                                                                     (CORIIVED)
tissni
4873
Crime














EXMSVBE BOUTS
r»1«etioB
Tngestioa











.


aMZTtlCll
BRBOD
ec














BOBBER
OF C»SBS
1














I1I6E
261.*-38.« na/dar














Ull
tat applicable














6EIIUL ZTF01B1TXOI
Car 1 *nd « after last dose of 500
•q/dar, (101 precrllMd dose), falves
iKlaa* •- »d p- hTdcoiT phenyl
•.

5.S re oU, *t 19 *taqna aad lateral
qaie aystaqaas foe T 4*ra or leas
after last «o»«.
BROGS; CHILBBCT; USOH5I1;
itnoowToisiRs: BLOOD msti; mm;
eisttotiTESiniL SISTSS: BBUS TBIB»PT
BEFEREICE
froitt, l.».
Iwiren, S.T.
Patterioa, 3.E.
Darton, P. 6.
Cook, C.E.
wall. a. I.
1975
Cllalcal Pharaacolo^r
and Therapeutics
18(1):112-120






Ijdraiia*
302-01-2
H-I2
B1  32.05.  »  2.0 C. BF 113.5 C at 760 n Bg, SC C at 71 aa 89. 170 C at 5 ata
1ISSBE
Htlne



EXMsuts soun




MUniCU.
HBXBOD
ec



E0BBES
0? cisss




IIB6E
a) lot given
b) Bot given
c) lot given
d) lot given



HE.B
a) 0. 48K of dose
b) 0.075S of dose
et 1.0* of dose
d) 0.21% of dose



GVItltli XBFOSfl&TlOB
a) Slo* acetylators. 100 sg dose. 7
a«b -Jests
h) ?ast aetrlatots. 100 sg dose, 13
aeblects
e) Slow acetrlators. 200 nq dose, 9
cableets
d) Fast acetTlators, 200 aq dose. 11
2* br nrlnes. Sim and fast
acetTlators differed at both doses.
p<0,02 and 0.001. resBeetiTelT
(TpecteaslTe patieata
HTJS3; 18111; BIITBS KIB6DOI;
BflSinVHBR BBTBOOS; BIZTflXS;
SITIBOITSH; IRtBTFSRElSIVI 169RS:
ccsp.sativz mtaiTiois
KFEBEBCE
Tlnbrell. J.I.
Bar-land. S.J.
1*79
Cllalcal Pharaacoloqj
and Therapeatics
26(1): 81-88



                                                                                                                                                                                          OJ
                                                                                                                                                                                          VO
                                                                                                                                                                                          VO
-------
co-sc-o
B« m.17, in
nssit
»8T>
Blool.
glasia
M76
•lool.
plasaa
1
1
> 1B*-1«8 C, BP 2
EIPOSHBB BOOTS
Ingestlon
Ingestian

DO C (sole decoap)
imYTICU.
BOTBOD
HP 1C
-
BPIC
	 	
BOSSES
OF C1SBS
15
*

~~ 	 iiiss"
a) 0.7-0.17 «g/nl
b) 1.8-0.5 nj/sl
e) 0. 1-0.65 ug/nl
, 	 	 	
0.03-4.3 »g/»l
'

BEaB
a) Rat 9 Iran
b) Wot given
c) Bot glren
Hot jlTOB

— 	 GZHSII iBPOBBiTioi
al 2 and 8 ar Mans after 69 »g
S^S'S's.'LSS'SSc M .,
r".e"&~Kon£.toi.. 2 ..* 12
hi after 60 iq »ethiM*ole. 1 patient
tt«.lo«l7 "treated '»-f7.JrKo" ,
.,p«rt»iroU patients. «t »».5-SS.8
kg. United «io-"•
Bclsrty, B.C.
Kalk, »-J-
1980
British Journal of
clinical P»ar«acologr
9:137-1»3
Knight . B.I.
Otter. B.
to*. L.C.K.
lleiander. "-B-
1980
British Joarual of
Clinical Phar»acolo»T
9!l«5-1»7

                                        -..t*xr2-.etj7tl-y(. °»a,
                                                                                                                                                                                         o
                                                                                                                                                                                         o

- ttsg,g —
• 177
Jlool.
pla-na







•878
Blool,
plasaa




p different forss
flfOSVB! BOOTS
Ingest ion








Ingestion




155 C, 16Z c
lialTTIcil
»rTBOD
ec-sc








us





BBBBSl
OF CaSBS
«> 1
M 1








5



.1 	 _ 	

	 B1BSI
•) 68-7.2 ag/nl
b) 390-120 ng/nl








0.31-0.63 ng/Bl



	 l«r
	 . 	 . 	 — — 	 	
gin 1
., ,ot applicable I •> Change ^^^'H"^.
b> Bot applicable 1 »s™;| Vstag error (2.0 sg/*»)
! Presatvre Infants »ith patent dnctns
I arterlosas. 27-28 »k qestational age.
! Failare to achieve permanent d«otal
1 elosare.
T ereaaed senn bilimbin. aecreased
J iriaarr e«tp«t, redooea platelet
I aggregation. SI bleeding.
! tsnss: WOG TBSBIPT; IBFIBIS:
| fUBSTtflMIl; CIBDIOTISCUL18
| TX9I&SBS: B1COO PLISnfc
« .1. .«m 1 Stead* state levels after 25 ng
O.K79 «g/nl J 3T/anT for «-» 4«T»-
' BealthT 22-29 yr oH nedical
students, on no other arags for >1»
I dat«-
1 D11GS- WDSB; CEinXTOID IOTHSITIS-.
1 BIOOB *USM: coaniKttB
| IftlOmtTOHS; CHIOSW OTS111C
t vmn
BERBBCE

rriednan. I.
Whltaan. T.
Balsels. B.J.
Sersan. B«. Jr.
Harks. K.B.
T«sell. Z>s.
1976
Joarnal of Clinical
Pharnacologv
18 (S-«): 272-279





llvan, G.
orne, ••
Pertilsson, 1.
rkstrand. t.
Palner. L.
Clinical Pnaraacology
•«d Therapeatlc*
1«(3)s36»-373
1
«____ 	 	

-------
C19-H1S-C1-B-0*
•• 357.81, M diffsrest fora* 155 C. 162 C
                                                                     CIJ
ixssn

»B79
Blool,
plena







••80
Blool,
clasaa









*mi
a«r«n







BlfOSBBB R001E
.
IngestioB







Inject Ion









Inlectlon








BBTHOD
BC-BC







CC-BC









OC-BC








BUBB3B
OF CUBS
at 2
b) «
c| 3







aj 8
bt 9









37








MICE
•t 0.027-0.052 «
-------
  ItOD
 It" 5S.S«7,  BP 1535 C  (pore),  1000-1300 C  (cast). 1500 C  (novgfct).  1300 C  (steal), BP 3000 C. TP  1  u  Hg at  1787 C.  10 ••  Hg at 20«0 C
TISSOB

4882
Brine











BXPOSOBE BOUTS

Ingest ion











IU1TTTC11.
BBTROD
us











IVHB2B
OF CASES
10











sues

•) lot given
b) Hot given











mi

a) < 2 ppn
b) < 2 ppn











CIIEB1L IIFOBBaTIOI

•) lean daily intake (supplemented)
ef 66 mg, fecal lass af 111 sg, Jata
froi 2* 7-dav experimental periods
t) Bean daily intake (nnsepplenented)
of 18 mi, fecal lass af 16 sg, iata
Iron 19 7-day experimental periods

University stadents and enpleyees, a
narse and a teacher. Unlliparous,
ages 19-Z9 yr.
TIIfESSEE; 01IIZ; ISOW; calCIOH;
B1S>BSIQH: BIREBUS; PHOSPHORUS;
CUTS; IHtBiL BBMBOIISB; PEEGMlICT
SiriSEHCE

iste, j.e.
Schofield. r.E.
Gran, R«B*
1979
ineriean Joaroal of
Clinical Intcition
32:2««-291






leonicotlnic acid hvdraziie (8 CI)
V-PTridineeatbezrlie add, kydrazide (9 CD
5»-85-3
C6-H7-»3-0
II 137.15, RE 171.* C
TISSU!



0883
Blood,
vhole







EIPOSDH RODTE IHLTTTClt BOBBBS
ItETHOB 0? CASES


In-tection Flaoronetry a) 1
b) 1

|

1
1
1

|
i I
I
«88«
tJriB*
























1
Digestion

























Sadiosetrv



























~
7
























8»GB



a) 28-0.9 ag/nl
b) 22-3.0 ag/nl









a) 2. 2- 3. 61 of dose
b) 9.0-12. »t of dose
c) 2.0-5.1* of dose
d) 16. 1-32. S* of dose
e) ««.0-52.«S of dose
f) 32.6-3».3T of dose
9) 37.2-51.0' of dose
h) 25.5-38.7* of dose


















Mil 1 "SEBIBIL tiroBBltlOI
1
1
1
a) lot applicable 1 a) Rapid aeetylator. 10 and 250 nln
b) Mot applicable I after f..2 sin IT of 670 nq
I b) Slo. acetylator, 10 and 425 nin
1 after •!.» nin IT of 681 nq
1 Tiezponential elinlnation. Estinated
1 fro* graph.
1 Healthy Caucasians, 29 and 50 yc old.
1
1 DBUGS: I'TiBClITES: RlSOREIEirT
1 5E1BODS: OSIIB; BtOOD; JLDILTS;
1 PITIBOLIS1; COBPJRITTTE ETlLtHTIOItS
1
a) 2. OT of dose 1 a) Isoniazid, 3 fast acetylatocs
b) 10.91 of dose 1 b) Isoniazid, 4 slov acetylators
c) 3.6* of dose I c) Isoniazid kydcazones. 3 fast
d) 26.51 of dose I acetylators
e) 09.2* of dose I d) Isoniazid hydrazoaes, « slow
f) 32. I1 of dose | acetylators
g) sa.«« of dose I e) leetrliseniazid, 3 fast
h) 30.5* of dose 1 acetylators
1 f) Icetrllsoniazid. « slov
1 neetylators
1 g| Isonicotlnic acid netabolites of
1 acetylisoniazld, 3 fast acetylators
1 b) Iscnicotinic add setabolites of
1 acetylisonlazid, * sloe acetylators
I Values for 2«-hr urines after •>
1 sg/kg.
1
1 Bealtky 26-39 yr aids, on nornal
1 diets and taking no nelications. to
1 hepatic or renal disease, fasting 12
1 br before and after lose.
1
1 CBTCS: OSVG THSS4PT; HRtB01IS8:
IIUYtltO: UBIBC; COBP1B1TI?!
1 ITlLOiTIOKS: tDOLTS
1
HMEBESCE



Boxenbann, R.G.
Biegelnan. S.
197*
Joarnal of
Pharmaceutical sciences
63(8|:1191-1197





Hitchell, J.K.
Thorgeirsson, 0. P.
Black, B.
Tinbrell, J.5.
Snodgrass, ».P.
Potter. t.Z.
Jollov, D.J.
Feiser. H.5.
1975
Clinical Phamacology
and Therapeotics
18(1): 70-79














inn *»sei
                                                                                                                                                                                          O
                                                                                                                                                                                          ro
-------
Keaieotiaic acid  hydras-lde  (8 d}
4-PrrlllBocartnxTllc acid, hrdrazldei  (» ci)
S4-B5-3
C8-H7-I3-0
CI 137.t5, HP 171.4 C
                                                                                      (COITIIOBD)

4885
Urine





BlfOSDBE BOOT!
Injection





1111 IT 1C U.
BBTBOD
	 — 	
Colorisetrr





IVIBra
or cisss
a) 1
b) 1





1U«B
a) 0.8-0.025 ag/ain
b) 1.0-0.15 Bg/ala




- -
BB1I
a) lot applicable
b) lot applicable





Giinii moBUTioi
a) Bapil acetrlator, 10 and 570 aia
after 5.2 ain IT of 670 ng
t> Slow acetrlator, 10 and 570 aia
after 5.4 aia IT of 681 ag
values for Isoaiarld plus its
brdrazoaes. Bstlaated fros graph.
Bealthr caaeaslass, 29 and 50 yr old.
BBAIGS; 1BTIBOIITBS: M1SOBBBEBT
RI1B093: QBIIE; BIOOO; »6tltS;
RETHOIISB; COBPHWITB ETIUJITIOIS
BETEBEICB
Boxeabaaa, B.e.
Klegelaan, s.
1174
Journal of
Pharaaceatical Sciences
63(8):1191-1197




I«oalp«cotic acid. 1->«tb}l-«-pae>fl-. atari «at«t H ci)
J^'i?*? iUMearbonrlle acid. 1-aethil-a-phenyl-. ethyl «»t«r  (9 CI)
5 f™«»2— »
C15-B21-I-02
R« 2«7.35. flt 196-189 C
1
1
«886
Blood




»8«7
Blool,
plasia







«8S8
91001.
acna








EICOS4BS MVTB

lalMtlan




I«1«ctlon







r«i«ctioR




•



1BU.TTIC11
imoD

ec




9C







OC








•DBBSB
Of CiSES

«) 2*
b| 13




a) 1
b) 1







a) 6
b) 8
c) 6








BUSS |
	 1
•) 11-162 ag/»l
b) 40-99 ag/al




a) »-0.3 «*/•!
b) 30-0.* aq/al







a) lot applicable
b) lot applicable
c) lot applicable







(HIT
Mai

a) 95 » or - «3 ng/al
b) 6* + or - 22 nq/al




a) lot applicable
b) lot applicable







a) 12* » or - 11
nq/al
b) 13* « or - 24
»a/»l
c) 130 » or - 22
nq/Bl







PICI)
GCItlal IIFOBBaTIOB 	

al ViBllleal cord. TeaoBS, at birth
*) Uablllcal cord, arterial, at birth
Bothers received 50 mg darlag labor
levels decreased as drag-birth
Intervals lacreased
14 black. It caacaslaa Beoaates. BOBB
4*atatlOBal age 39.4 wk, eeaa birth
at 3310 g.
OBIGS; pirsiiKT: BIOOO: OKIE:
SWlBOlTtlS; 0«IO; 7HBIHCH COBD:
IMB01»
a) 15 all aad 9 hr after 5 aq/kq
S»se. laitial eeasareaent 3 aq/al at
5 all. irterial vessel clasped
tetveea 1st and 2nd hr
t) Initial aeasBreaeat and 9 hr after
5 aa/ka dose, irterial vessel
clasped betveea 1st aad »tn hr
Sargieal patieats vith peripheral
vascBlar disease
ClSDIOTlSCIJtlB DISUSES) BIOOD
E11SH1; IIIIGESICS; DBQG TBIB1OT:
oancs
a) Bea, peak at 1 hr follovlag 50 sg
II of the hrdEochloride
t) losea. peak at 1 hr follovlag 50
ag IB of the h7drachlorlde
c) Vosea OB regiaea of
eatrogea-progestia oral
contraceptive, peak at 1 hr folloninq
50 sg It of the hTdrochlorlde
lealthv 21-2* ft olds
IC01TS; BIOOD: BtOOD SBBUB;
II1LGESICS; CBVG HTCT1CTIOB; OB1L
ccnticBPTiTis: DBDG TBEIIPT:
IIICOTTCS; VBIIB

lETBIIEtCZ

Kahaert. B.I.
Rvhaert, t.s.
Ta, 1-S.l.
LIB, D.C.K.
1979
laerican Joarcal of
Obstetrics aad
Srnecologr
133 (8): 909-91*



Koska, I.J., III
Kraaer, t.6.
Rosagaoli. i.
Sabavala, P.B.
1981
laesthesla aai
laalgesia 60(1): 8-11



-
Stasbaagh. J.I.
Vaiaec, I.w.
1975a
Jonraal of Clinical
Pharaacologr 15:46-51







	
                                                                                                                                                                                           O
                                                                                                                                                                                           LO
-------
S7-82-1
C 15-B21-I-02
II 2*7.35. SP 186-189 C
TISSUE ~ IIKSnl MOTE
• 889
orlne
•890
Drlne
«891
Urine
1
'
*-plperiainec
77-17-8
Bl 233.3*
IISSOB
«892
Blool

Injection
Injection
Injection
•xrosots tome
Injection

IHLTTICtL
RETBOD
«C
ec
oc
ilUTTICIL
flSTBOD
«C/»S

IBB BIS
b) 8
el 8
2*
8
r (9 CI)
b) 10

(COBT
8 USE
a) »o* applicable
b) lot applicable
c) lot applicable
lot applicable
0.5- 1H. 25 ag/»g
creatlnlne
	 "~ MISS
a) 5-38 ng/sl
b) 2-*2 ng/al
HUSO)
IE1I
a| 3.17 ng
b) 3.66 ag
e) 3.67 ag
3.27 ng
lot given
	 GBMlll IIPOtBaTion
a| 6.3t of aose, sen
b) 7.3^ of aoae, iionon
e) 7.«« of aese, »onen taking
eatrogen-progestin oral
contraceptives
*l hr ensalatlve excretion after so
•<) in of the hrarocliloriae.
Bealthf 21-28 yr ol«»
1B01TS- OBIIE; HllGESICS; DBOS
IRBIICTIOB: osn corrtiCErnvES:
DIBS IBBtaPTi BtOOD» BWOD SBROH!
IIICOTTCS
— — 	 	 • 	 : — —~—^~~~
«l hr c«nnlatlve excretion, following
50 ng« IB as hyacocbloriae
B«althv 21-30 yr oias
n|T|£. alKl'CZSTCSS COHPftBaTITB
EV»HJ»TIO»S: B»*coTics; oaoss
— 	 	 	
Bothers recelvea SO ng anriag l«bo'-
revels (estlnatea froa graph) anMag
first 3 aays of life. l*"»J* '•Fj;fll
•1th aay of collection ana arag-blrth
Interval. Clearance not conplete at
lays.
1* black, 16 Cascaslan neonates, nean
aestatlonal age 39.* «k. nean birth
•t 3310 g.
nines- PiBSilicy; BIOOD: OBIIE;
BII1BOLTTE3: OHO: OSSI1.IC1L COBD:
IKBOII
	 tEFEUICZ
Stanbangh. 3.t.
(alner, !•••
Journal of Clinical
pkarnaeologr 15s»«-51
Stanbangh, J.E.
•alner, I.I.
19T5b
Jonraal of Clinical
Pbacnacology 15:269-271
Knhnert, B.B.
Knbnert, P.B.
to, t-s.l.
tin. D.C.K.
anerlean Jonrnal of
Obstetrics aaa
Gynecology
133(8) :909-91»

iizii
a| 17 * or - 1* ng/nl
b) 15 » or - 13 ng/al
GSIIBII. IIPOSB1TI01
•t Onblllcal eora. venoos. at "jfjj|
c "•blllcml coci, arterial, at birth
nothers received 50 ng noperiaine
Jnrlnq labor
levels nnrelatea to arag-blrth
Interval.
1* black, 16 caacaslan neonates. jean
qestatlonal age J9.» vfc, nean birth
•t 3310 g.
CBOGS: PII6IMCT; BtOOOS OBI*!:
BtTWOtlKS; OHIO; niiBiliCM COID:
IIWBOPI
fBCZBB**-*
Knhaart, B.S.
irahnert. P.B.
IB, »-s.t.
Lin, D.C.K.
1979
Inerlcan Jonrnal of
Obstetrics ana
Gynecology
133(1): 909-91*
	 litir PNSBI
-------
XsoBlpscotIc acid, a-Bhearl-,  «tfcrl ester (» CD
                       ac"' «-H"«Tl-.  etkrl ester  f> CI)
C1I-B19-I-O2
It 233.3*
   tissm
 *M3
 OrlB*
 •89B
 flrlae
  urine
 S7W-77-*
 «-OT-C12-»
 M  239.55
    TISS1I
   »89«
   Blood,
   )>!•*•«
             ETFOSVIE BOOIB
                                                                                    fCOMIIVED)
iBJeCtlOB
Injection
              lajectioa
                 OC
                              ee/ns
                                       •tUBBI
                                     OF cms
                                    a) 8
                                    b» 8
                                    3 8
                                     2*
a) lot applicable
b) fot applicable
c) lot applicable
                                                 lot
                                                               0.6-3.75
                                                                             cnatlala*
                                                                                                  Mil
                                                                                          a)  3.3* mg
                                                                                          b)  a. oi 19
                                                                                          c)  2.53 19
                                                                                          3.69 ag
                                                                                          lot giT«n
 7.e-dlckloro-1.2,3,*-tetrakTdro-, hydrocklorUe

1-B
              BXPOSOn 1O01B
                                  aiutncu
                                    BETBOD
                                       »BB!B
                                      or caszs
                                                                                    (BIT* •!<:•)
                                                                                                                           esiiui  TiroBiitioi
a) C.7* of dose, eea
b) 8.01 of dose, woaea
c) 5.1* cf dose, loaan taking

contraceptives
•8 fcr caanlative excretion after  50
BO, IB of aevexldlne kydrocklorlde.

BealtkT 21-28 Tr olds
                                                                                                                         ami: iiucMics; OBOG
                                                                                                                         •I0»; 0111 CORS1CBPTITES;
                                                                                                                 «JO« MSBMTJ aiOOD; BMOB 31108:
                                                                                                                 HtCOTJCS
                                                                                                                  «« kr cnanlatlve excretion follovlao
                                                                                                                  50 ag. M as kvdrocklorlde

                                                                                                                  BealtkT 21-30 jt olds
                                                                                                                               iiic«Tics; ranes
                                                                                                     Cotkers received 50 «q dose
                                                                                                     Beperldlie daring labor,  levels
                                                                                                     leitlaated froa grapk) daring first 3
                                                                                                     days of life,  levels varied with dav
                                                                                                     of collection  and dr«g-birtk
                                                                                                     Interval.   Clearance not cotplete at
                                                                                                     3 days.

                                                                                                     1* black.  1C Caacaslan neoaates, aean
                                                                                                     geatatloaal age 39.* »k, B«aa blrtk
                                                                                                     vt 3310 g.

                                                                                                     Dines; -piisiucy: SIOOD; nun:
                                                                                                     ertiBoiiTss; onio;  ntsnicii coiv;
                                                                                                     •IIBOBl
                                                                                                                                                                BWMIJCS
Staabangh. J.E.
•alaer. 1.1.
1975a
Joaraal of Clinical
PkarBacologr 15:«<5-51
                                                                                                                                            Staabangk. J.!.
                                                                                                                                            •alner. l.B.
                                                                                                                                            1975b
                                                                                                                                            Journal of Clinical
                                                                                                                                            narnacologr 15:269-271
                                                                                                                                                         Kahnert, B.I.
                                                                                                                                                         Knkaert. p.B.
                                                                                                                                                         19. l-S.l.
                                                                                                                                                         IlB, D.C.K.
                                                                                                                                                         1979
                                                                                                                                                         laerlcaa Journal of
                                                                                                                                                         Obstetrics and
                                                                                                                        O
                                                                                                                        Ul
                                                                                                                                                          133(8):909*91«
                                                                                                                           6s»ui iirosuTioi
                                                                                                                           .,.   X.UU1
                                                                                                                               ° s Kt
                                                                                                                  lealtby 21-33 yr olds,  vt 59-95 *g.

                                                                                                                  llld gastrointestinal effects  attec
                                                                                                                  kr.  Fatlgae or sleepiness after  2
                                                                                                                       ! «KT«S: BLOOD PLISHI,
                                                                                                                                                         Clinical fkarsacologr
                                                                                                                                                         and Therapeutics
                                                                                                                                                         25(6): 837-8»3
-------
IT987-77-6
C9-B9-C12-B.C1-B
BB 238.55
(COBTIBOBD)
                                                                                                                     Kalthy  J1-33 Tr oias.  «t  59-95  kg

                                                                                                                     •114 gastroi«testlaal effects after 1
                                                                                                                     Ji.   ?atig«e. or sleepiness after 2
                                                                                                                     br.
                                                                       Dabb, J.*«
                                                                       State, H.B.
                                                                       llexanaer, T.
                                                                       latoccia. ».P.
                                                                       GeeiT. ••
                                                                       pe»ai«ton. B.G.

                                                                       clinical Jharaacology
                                                                       B»a Therapeatics
                                                                       25 («J : 837-8*3
I-lscorblc acii
50-81-7
tissoB
•898













*899
plassa









BIPOSOBS tOVTt"
	
ingestiOB













I.gestlo*









	 illtTTIC«i
























or cisss i
i 	 	 • 	 	 	
, J a) 5».89-7J.83 ug/10(B*8|
i b)"*. 19-77.97 ug/10(B*8)
l cells
cTi*. 88-60. IS ug/10(B»8)
1 cells
i d) *S.07-*3>85 ag/10|B»8)
j '•71M.61-al.13 «g/10|B*8)
i f) BS. 95-37.8* ag/10|B»8)
| cells
1
1
1
1
1

t
1
1
s ! a) .57-2.16 ag/100 .1
6 J w -6»-2.83 ag/100 al
I el . aa-2.63 ag/IOOal
d .13-2.17.9/100 al
. .36-2.60 .g/100 .1
| f) .30-2.66 .g/100 al
1
1
1

1
1
I
1
1
1
t
\ \
» 	 	 — l 	 — 	 "
	 sir 	 r «««" »""""•
b) Bot gi»ea j Jf*!0I*,!a'12*Br*aft«r*W« ag plas 300
e) Bot girea J» .^^.licylic acid (»s«.
4) Bot gi«. j J^JHe talae. 63.7* ug/10(E«8) cells
?! It ai»en 1 c' '•' *** * *r **J*r «S g|
II ™ » I 19 *S1. Preocse Tane. *
I na/10(l«8) c«ll«^r iflM M plnj M0
I ag aS(. Predose »alue, *3.»8
1 «00 ag »S». Predose Tain*. «3.«1
1 09/'j"(" ' , after 2000 .g plas
i 600 ag »S»- Predose »alne, «2.7S
I 09/10(^*8) cells
1 leukocytes
I B«althy stadents. aoasaokers,
! S.iJersitT of 9«bUa. Trela.a.
! T»n»iii): »D«IS: WOOD; SIOOD PIIS»»!
1 ItDKOCTTZS; II116BSICS; VBOG
j ii?mc*ioi; Tir.gBS; TitMnr c
ii05 u<3 2 hr after 500 • , IMKOCTTBS; »'^*^!:,I"BH c
*( 	 . 	 \ 	 — 	 "~

	 lEFEBEBCE
•>_«, • 5
J,O n f n»*«
(ilsoa, C.S.B-
journal of Clijical
Ffcaraacology 15:36-45












loh, U.S.
vilsoa. c.».s.
joaraal of clinical
Pharaacology 15: 36-* 5




|
J
t
1
1


-------
t-PcsllM,  1-(3-Bereapto-2-«ethvt-1-o*opropyl)-.  (S)-
«2571-8S-2
C9-B1S-I-03-S
II 217.31
TISSOt

»900
Blood











*901
urine











nrosBBS soon

Inqestion












Inqestion












alUTTICll
BETHOD
ILC
Badiocetry











ttc
Sadiovetry











ITTBBKI
OF C»SBS
10












10












EIIGB

a) lot given
b) lot given











a) lot qivea
bj lot give*
c) lot given
4) lot given









BUI

a) 800 » or - 7(
ng/al
b) 1580 » or - 90
ag/al









a) 38.1 » or - 1.99*
of dose
b) 1.»8 » or - 0.15*
of dose
e) 26.2 * or - 1.11*
of dose
Jim ff JM f.M JIAMM
Q| W.Vn OZ QOSv
(S.E.)






GZIISlI IIFO1I1TIOI

a) Bean peaX at 0.93 * or - 0.08 kr.
»cliaa4*d ietg
t] B«as peak at 1.05 » or - 0.08 hr.
total caaioactlTitj (as captopril
•qaivalanta)
Ifter 100 mq. labell«4 dos«

laalthr, 18-35 ft old eancaslaaa. »t
S». 2-85.0 ka, fasted before and after
dose.
IITIRTPSHTBISITX 1GERS: BLOOD:
I1III: FICIS; RR1BOLITIS;
BIDIOISOIOPfS; UOI.TS
a) Captopril
b) Captopril dlsalflde
e) 
-------
 •7-22-7
rasa—
»»OJ
Bll*
•*0»
91004,
plama
(905
Vrla«
	
tifoson BOOM"
Injection
In1«ctioa
ln-)«ction

	 illlTTICil
SSTHOD

taaloMtn/BWC
	 	 —
BaBioaet rr/9*1*

I01BR
or casts
i
1
i

»»••»
21.7-1. •< «* a°**
28-0.5 •»ol««^
21.6-1.5* of «o««

                                                                                           •at  applic«til«
                                                                                           lot applicable
                                                                                           tot  applicable
                                                                                                                                                         jaekoom. ».*•
                                                                                                                                                         S«ad«r,


                                                                                                                                                         Cllmical WiaraacoloaT

                                                                                                                                                         and
                                                                                                                                                          JacfcsoB, D.T.

                                                                                                                                                          castl*. 9-c-
                                                                                                                                                         Cl la leal SharaacologT
                                                                                                                                                         and Tk*r»p»aticB

                                                                                                                                                         2»|1) ! 101-107
Jackson. O.V

castl*> B-C-
Bm««c, B.I.


Clialcal

and
2» (1)-101-
                                                                                                                                                                                        o
                                                                                                                                                                                        00
titkia'
    -93-


    6.9«1.  «* «°-5» C< BP  '"*



             •>i»*on »""
-------
•-BeBxeBedlsalfoBaalde. 4-CBloro-f(t)-MthTl-»O)-(tetra»7dro-2-BethTl farfsryD- (8 CI|
1,3-Benzenedlsulfanaaide, 4-chloro-»f1|-a«thrl-»(1|-{(tetrai7aro-2-setByl-2-faranyljBethrl)-
719S-27-*
C 13-B 19-C1-B2-05-S2
N 382.90, 8? (41- foraj  1*9-150 C,  (d-  for*)  1*6 C.  (1- for*)  146  C
CT|
1 nssnB
i
i
t 4907
1 Blood,
1 cells
1
I

1

1
1

1

|

1
I
1
1 4908
| tlool.
1 plasaa
I
1
I
1
1
1
I
I
1
1
I

I 4909
1 Oriae

1
|

•
•
1

•
•
1
I
1
I
1
1
POSHES SOtTTE

gestion
















ngeatioB














Ingestioa

















iiaimcii
HMHOD
oc
















oc














QC

















IOBSB1 | 81ISI
or cisss i
i
1 a) 1.82-3.53 sg/1
1 b) 1.49-2.51 sg/1
I c) 0.83-1.05 ug/al
I d) 0.11-0.54 ug/al
•
I
1
1
1

1
1
1
1
1
1
1
t
I a) 68-128 ng/al
| b) 76-84 ag/al
1 c) < 5 Bg/al

1
1
1
1
1
|
|
1
1
I
1
8 1 a) 0.3-1.11 of dose
| b) 12. 0-14. W of dose
I c) 34.6-54.2% of dose
t
1

1
1
1
1
1

I
1
1
1
1
1
ISM | GBiniL nrOIBITIOI
!
•ot gives 1 a) Peaks, 1.0-5.5 hr after 50 ag, 6
•ot givea 1 subjects
•ot givea 1 t) Peaks, 2 hr after 25 ag, 2
lot given I subjects
1 c) Peaks, S-ozo-aefroslde after 50 mq
1 aafrusida, 3 subjects
I d) Peaks, open acid aetabolite, S-8
1 tr after SO ag Befraside. 3 subjects
1
1 Bealthy 21-24 yr olds, vt 61-84.5 kg.
I no other aedleatioa at least 1 aoath
1 and fasted before dose.
1
1 OSDGS; DIBFtTICS; XlalY; BtOCD
| IllSRa; EBRBBOCITES; BSIIE;
I tttaBOLlTES: 1DD1IS
1
|
) lot given I a) Peaks. 1.5-5.5 hr after 50 ag
) 80 ng/al I b) Peaks. 2-2.5 hr after 25 ag
c) lot applicable I c) S-oxo-aefruslde and its open acid
1 analogue. Dose route and tisa of
1 saaple not specified.
1
1 Healthy 21-24 rr olds, vt 61-84.5 kg.
1 BO other abdication at least 1 soath
I and fasted before dose.
t
I Itnes; DIOBETTCS; ITaLT; B1OCD
I fll$*>; BUTTHBOCTTES; TOIIJ;
I IIllBOLITZS; 19OHS
1
1
a) 0.49* of dose I a) Excretion of anehaaged drag
b) 13.1* of dose I extrapolated to infinite tiae after
c) 46.2% of dose I '0 or 25 ag, 8 sabjects
1 b) Bxcretioa of 5-oxo-aefrnside
1 aetabolite at infinite tine after 50
1 ag. 4 subjects
1 c> Excretion of open acid aetabolite
1 at infinite tiae after 50 sg, 4
1 subjects
1
1 lealthT 21-24 rr olds, vt 61-84.5 kg.
1 ac other aedicatioa at least 1 sonth
1 and fasted before dose.
i
I BWGS; DIURETICS; ITU.T: BIOOD
| ?l»S«lj EBTTBROCTT1S; BSISSj
I B'TIBOVtTIS: IDOLTS
1
SBTSSIBCB

'leuren, H.L.J.
vervey-vaB Viaaea,
C.P.v.
Tan Bossna. J. H.
1930
European Journal of
Clinical Pharaacology
17sS9-69










Fleurea, H.L.J.
Tervey— van Hissen.
C.P.I.
fan Eossun, J. a.
1980
European Journal of
Clinical Pharaacology
17:59-69







Tleuren. B. l.J.
vervey-van Tissea,
C.P.u.
Van Koaaua, J. M.
19«0
European Journal of
Clinical Pharaacology
17:59-69










-------
BetnaaesalfoMBilide. »'-f1-hydroxT-2-(iBoproprta«lno|«tliTl)- (8 CI)
Bethnnesalfonanlde. *- (•-O-hyaraxT-2-((1-metIiylethyl|a»!lno)etByl)phenylJ- (9 Cl)
3930-20-9
C12-MO-I2-03-S
81 272. IS


1
!

tISSD!
Mio
Blood
•911
BlOO],
plasaa
1
1
1
»912
91004,
plasu
«913
Blood.
sens
91»
tain
BIPOSUSJ BOOT
Ingestion
Ingestlon
1
1 I n lac t too
1
1
1
1
I
1
Ingestion
Ingestlon
I
1
1
E iMinicii
HETHOD
GC-EC
flaoroeetry
Plaorontry
'laoronetry
9C-EC
108 BIB
OF C1SS
1


12
1
HUGE
»ot given
•C70-450 nioles/1
3-5* of dose
1.4-1.7 «9/l
lot given
given
Ssli T e*Bii»i nMtunoi I BMBMCS
,'
I I
10.0 ng/sl 1 lotopsy, alter 3.2 g 1 Bontagna, H.
I I Groppi. 1.
| 47 yc old subject I I960
1 | irehlTM of Toxicology
| Si otic, aqltatvd. Convulsions, 1 «3: 221-226
I ttaarcacflia, abnocaal KG. reinced |
1 tlood pcessqr*, cardiac arrest, 1
1 fibrillation, death. I
1 1
| 1ITTRTPERTIISITE 1GEWTS; SUICIDE; I
1 IT1LT; nsns IBVSI: IOTOPSIES; t
I HISmiBWT BITHOffS; 9MII; HURT; I
I I01ICS; LITEF; KieiTETS; BLOOD; tTBIUS; I
| C15E 8ISTOIXES 1
-1 1 	 	
lot giT«n I 2 and 40 hr waia after 320 ng/dar 1 Johansson, S.S.
| I Recall, 8.
I Healthy 20-30 rr olds, vithin 10* of 1 (ilhelBSson, c.
1 nornal weight. 1 Tea in, J.l.
| I 1980
| fttJnced restioq and exercise heart 1 Clinical Pharaacologr
j Tates. ledvced blood pressure. 1 and Tkerapentics
| I 27(5|sS93-601
| ElffSS: SIID1I; BIOOD PllSRi; t
| 1RIRTPEBTIIS1TE JGSHTS; COHPJS4TITI |
I IT>LOatIOHS; 1DU1IS; B1000 PSESSTOE I
1 1
1 1
lot given 1 Beans, 0 and 1(5 nin after 1 ng/kg. I Schnelle. X.
I IT. Dose preceded by stimulation of I Kiel*. G.
I teta-receptors *lth isoproterenol. I Schisz, A.
| | 1979
I BealtkT 22-35 yr olds. | Journal of Clinical
I 1 Flarnacology 19:516-522
I eeta-adrenerglc blocking effects on 1
j heart rate, diastollc pressure, and I
| plasm lactate, glvcos*, pycavate, 1
| and free fatty acids. j
1 1
I HOGS; sfBRin; BLOOD Plisiu: BLOOD I
I fsissngs: IIIIHTPBFTHSITB »GE»TS t
l - t
1 t
1.C8 * or - 0.07 | a) Peaks, 2-3 hr after 160 ag. I Snndgnist, H.
/I | Elexponential decline 1 Unttila, 8.
1.»5 * or - 0.09 I t) lean peak, at 3.4 * or - 0.2 hr, 1 Sison, t.
/I | after 160 sg nith 25 ng I Feich. J.!.
I hiiroeUorothiazid*. 1 1979
j 1 Journal of Clinical
| 8«althy 25-57 yr olds, rt 53-86 kg. 1 Pharnacology 19:557-5«»
I 1
| CHUGS; iRTiaTPEF.T»SITS aGHIS; 1
I BIOBETICS; BIOOD SK10!l; OBIRZ; 1
I CC<)P»8»IT< ETI1QITIOI5; 1DDL*S |
1 1 .
1 1
59 »n yr old satject 1 1990
| | archives of Toxicology
| Clotic, agitated. Convulsions, 1 *3: 221-226
1 biadycardia, abnornal ECG, redacod I
1 tlood press»re, cardiac arrest, 1
1 fibrillation, death. 1
1 t
I miHTPTBTNSIVE IGtRS; SUIC1DI; 1
| IllLT; BBUG 1BDS1; 1TIOPSIES; 1
1 BIISOSMSIIT BET HODS; BB&II; B115T: I
I IIIIGS; LlflB: KID«ETS: BIOOD; U8I1E; 1
1 CIS! 1ISTOST1S I
1 1
(KTt lint)
                                                                                                                                                                                          -c-
                                                                                                                                                                                          h-'
                                                                                                                                                                                          O
-------
-------
   MthanesBlfcBanilide. »•- f l-hTdroxy-2-(isopropylanlBO) ethyl)- 16 CI)
   Rethaaesnlfonanide, B-{a-(l-avdroTy-2-| (l-aethylethvl) asiao) «thrl> phony 1) - |9 CH
   3*30-20-*
   C12-H20-I2-03-3
   n 272.36
                                                                                         (COITIBVED)
TISSUE



«ei»
orlne














•*20
Urine







1
EXPOSURE BOOT!



Ingestlon















Ingestlon I
1








IBaLTTICAl '
SETBOD


ee- EC















riaoroeetry









fmBBB
or CISES


i















12









sites



Wot given















Rot given









•EIF | GEIZB1L moSHTIOI
1
1
I
»15.7 ag/ll | letopsy, after 3.2 q
|
1 47 rr old subject
1
1 Hiotic, agitated. Convulsions,
1 bradyeardia, abnornal ECO. redncel
I Hood pressure, cardiac arrest.
1 fibrillation, death.
1
1 IBtlBTPElTSSSIYI 16SITS; SUICIDE;
I mil; DIVS isnsi; itrropsiBS;
I IIISmnZIT BBTHODS; BR1IH: BUST;
I -tOISS; IITEH: KIDRTS; BLOOD; TUQUE:
I CISE BISTOBIIS
1
1
TDK of dose | 72 hr enialatlve eicr«tion after 160
1 14. Slight IT higher Tallies rtth 25
1 19 hTdrochlorothiaxlde.
1
| H«althr 25-57 rr oils, vt 53-86 kg.
1
I DBBGS: IWTIHTPISTBJSITB »GSfTS:
| CIDBBT1CS; BtOOO SB BUS; OBIS!;
I COHrUJkfXVE ZT1101TIOIS; ID BITS
1
BETEEEICE



HoDtagaaf V.
Groppl. 1.
1*80
Archives of Toiicologi
13:221-226











Sondgoist, B.
inttlla. B.
Slaon. 1.
Belch. J.I.
1979
Jotmal of clinical I
Pharnacologr 19: 557-56 a |
1
1
I
9orphlMH-3-ol,  17-nethrl-
77-07-S
C17-B23-I-O
HI 257.3S. "IP »«-19» C
IISSVS

1*21
Bile















«922
Blool













A
| ETFOSORS BOUTE

Ingestion
















TngeatioB













\
\
1IUTTIC11
BETBO9
TLC
















nc















RV83EI
or cisss
1
















i















Hives

Mot 9! rea
















Hat given















mi | czuniL urosBiTioB
J
t
24.0 ag/«l |
1
I «1 vr old, ht ICO ci, »t 61.23 kg.
1 CiliforBia.
1
1 Boderate aioait of frothT heiorrhagic
1 flail in tracbeobronctal tree.
1 tolerate pnl*oaarr ed«ni and liiiial
I evphrseaa. vaftcnlar engorgeaent of
1 liver, spleen, kidneTs. «odnlla, and
1 sflaal cord.
1
1 tBlSS; BtOOD; IITSB; BB4II; LDIGS;
1 KiDiiis: mitt: BUB; CISE HISTOEUS;
I E«OG *•«$!; CUIrORni; SDICIDB
1
1
2.7 ng/nl I Eiazepa* alsc detected.
1
1 M vr oil. ht 160 en. «t 61.23 kg.
1 California.
1
1 Boderate aaonnt of frothy aesorrhaqic
1 fluid in tracheobroBChlal ttee.
t BoSerate palioaarr edesa and nlninal
t cnvnTseaa. vascnlar enqorqenrat of
1 liver, spleen, kilneTa, nedilla, and
1 atl»»l cord.
1
I osiss; BLOOD: LTTM: BBMI; io»5s;
1 niDIETS; USI1B; BTLB; C1SI BISTOSIUS;
I t«a« IB1SE-. calttOBlIa: St)lCIS«
I
SSrEBEBC!

Tnrner, J.I.
Pichards. E.G.
1977
Journal of Inalrtical
Toiicologj 1:103-104












Turner, J.E.
Plchards, B.G.
1977
Journal of Analytical
Toxicology 1:103-10*











-------
Berphlaae-J-ol,  17-Mtfcyl-
77-07-S
C17-B23-I-0
81 257. It, OP m-m C
tissue
«»23
Br*l>
MM
Kidney
eifosoBE jotrii
Xageatioa
Xngeation
M2S |
line I
*«6
t«ng
Ingestlon
Ingestion
» III TTICH
BETBOD
nc
TIC
TIC
TIC
IDRBSI
F C1SKS



1
B1BGE
t giren
Ot glV«n
•ot gl*«n
lot given
8B1I | 6EIMAI nrOBBlTXOI 1 BETEBEBCE
1 f
1 1
8 ng/g 1 I Turner, J.S.
| I Bt chard*, B.C.
I 41 yr oU. ht 1«0 en. »t 61.23 kg. 1 1*77
j California. 1 Journal of analytical
I 1 Toxicology Is 103-10*
j Boderate aaoant of frothy henorrhnglc 1
I flaid li tracheobcottCial tr««, I
1 iod«rat« pnlaoaarr «4eia and linlaal I
1 «i(itT3aia. vascilar enqorqeient of I
| li»«r, splcei, kilnefs, aadalla, and I
| «$laal cord. I
1 1
| B1HSS; BLOOD; IITEB: B81II; tOI6S; 1
| tlftlETS; DIIIX; BTL1; C»SE BISTOEI1S: 1
1 tsns iBosz; citirosin; SOICIDJ i
» >
1 1
% ag/g 1 1 Turner, J.E.
| I Blehards. P.G.
| 11 yr old, ht ICO ca, «t 61.23 kq. 1 1977
| California. I Journal of analytical
| . ) Toxicology 1: 103-10*
1 8o8«rata aacgnt of frothy bcaorrhaqlc 1
| (laid l» tcacbeobconclal tr««, 1
I io4«rato palaonary edeaa and ainlaal j
1 •aviyseaa. *a>c«lac eagorgeaent of i
1 liT«r, spleen, kidneys, nadnlla. and j
I tflnal cord. I
1 I
| DSDCS; B1OOB; LITEB; Bill I; LBKSS; |
1 KIDBBTS; DBIK; BILE; C1SE BISTOBIZS; I
I cios lensi: citiroBm; SOICIDE i
. . . . i i
1 I
5.* ng/g I Ilaxepaa also d«teet«d. 1 Tomer, J.E.
1 1 Blcharda, B.C.
I *1 yr old. ht 160 ca. «t 61.23 k
-------
  Rerphinan-3-al.  17-«ethyl-
  77-07-6
  C17-H23-R-0
  8* 257.JS, IP 191-199 C
                                                                                        (COITIRTED)
1ISS3B
•927
Urine













BXPOS1TBE ROUTE
Ingestlox











1
I
aRUYTICal
HBTHOD
MC













BOSBZ3
or c»sss
i
I
I











sues
lot giTen













§EiI
2.3 B»/al













CEIZBAl XnOlIWIOl

«1 rr old, lit 1«0 ca. wt 61.23 kg.
California.

floderate aaOQBt of frothy heaorrhagic
fluid in tracheobroaeial tree.
•derate pnlsonarr edeaa and ainiaal
espnyseaa, Tascnlar engorgesent of
liTer, spleen, kidneys, aedalla, and
spinal cord.
DROSS; 81000: LITER; BBIIB; IDRGS;
KTDRST.S: OB HE: BITE; CISE HISTOFIIS:
IBIS *30SE; CILIFOBRIl; 5HICIDB

IETEREICB
Tacner, I.E.
Eicharda, E.G.
1977
Journal of Inalftical
Toticologi 1:103-104










Borphiii»«-3,1«-diol,17-(crelob«tTlaethTlJ-
«2«08-S2-2
CZ1-B29-I-02
»I 327.51
                                              CI)
1 TISSUE EXPOSURE BOOT! I IHLTTICil I ETOBS3 I BARGi
I METHOD J Or CASES I
1 1 1
1 ... .1 	

f «928 Injection BPLC 6 a) 0.15-1.* ng/sl
1 Blood, Ingestion b) 0.75-2.1 ng/al
| plassa c) O.U-O.W ng/al
1 d> 0.19-1.0 ng/sl
-
.
• j
. 1
1 I

1 1

• 1
1
1
1
r
1 1929
urine
















In-fectioa













BPLC














BEAR 6ERBBA1 IBFOSR1HOH 1 SEFE8EKCB
1
1
a) Rot giTen a) tfter 1 ag as tartrate, IT I Garer, B.C.
c) Rot gireo c) HTdroxybatorphanol (wtaballte) 1 Bong, R.
1) Rot giTen I after 1 ag as tartrate, IT 1 HonkoTic. I.
I dl Bylroxwbatorphanol (aetabolite) I Svigor, J.E.
t after 2 ag as tartrate, IB I Tan Barken, D.R.


1








a) «
b) <












1
1






a) 12- set
bj 29-67"


















a| Rot giTen
b) Rot giTen












labelled doses 1 Sayth. E.D.
Ectisated fro* graph 1 1980
I Drag Setaboliss and
B«althr 22-28 Tr olds, wt 56-86 kg, I Disposition
Canada 1 8(0) :230-235
1
C1RAD1; ADDItS; BLOOD ttlSBA; DEIWB; |
UIICSSICS: COflMRATITE ETIltHTIORS; 1
RfTABOLISB; RET1BOLITES |
1
1
a) 10 ail 96 hr after 1 aq as I Garer, B.C.
tartrate, IT I TasiljeT, B.
h) 10 aad 120 ar after 2 ag as | Rong, R.
tartrate, IB 1 Honkoric, I.
labelled doses 1 Snigor, J.E.
l«aa cnaolatlTe percentage of 1 Tan Harken, D. B.
radioactiTitr 1 Sayth, B.D.
1 1980
BealthT 22-28 Tr olds, »t 56-86 kg, I Drag Betaboliea and
Canada I Disposition
1 8(9) :230-23S
C1WID1: ADVLTS; BLOOD PLASBA: ORIRE: 1
IRtLCESICS; OMPIBATITE ETRLOATIORS; 1
nrtiBOLis-i: IETABOLITIS i
-------
57-27-2
CT7-BW-B-03
•I 28S.33, up 197 c rtetastable plase), 25* C  (decosp)
- (»
TISSUE

•930
Blood,
Plena







•931
Blood.
plassa







EtPOSVn 80DTE
	 .
Injection







Injection







IBM met i,
BETBOO
^— — — — — —
m







SC-EC







i — i5ii 	
or CISES
	 	
8







30








	
B) 320-700 ag/nl
b) 51-62 ag/Bl






.
a) 1.900-3 ng/nl
b) 60.3-72.2 ag/Bl








flllV
•1 555 ng/nl
b) SS ag/sl







-
a) Bot given
b) 6«.5 ag/al








GIBEB11 IBFOBBITIOB
	 — 	 . 	 	 	
a) Peaks, issedlately after 10 sg IT
to 4 ssbleets. estlsated fros graphs
rj Peaks 15 SB after 10 Bg IB to 5
t objects
adBialstered as solfate.
Beamy 26-32 yr olds. «t 62-100 kg.
oapleasaat, dyspaorlc seasatloa
terslstlBq »-« kr after infusion. 1
ssbject aaeseated aad waiting.
(f(«cts less severe after
iBtraaascnlar injection.
MUSS; IttlBOLISB; BtOOO PllSftl;
SISSICHOSBTTS; CONPlBtTIVE
lUtOlTIOMS
- — 	 	 _ 	
a) 2.S and B to after 0.15 sgAg
single dose before sargery to 2
gioops, ages 1-6 yr and 7-15 yr. Bo
effect of age
b) BUiaon concentration necessary
foi sapprestUg clinical slges of
(aln daring nrgery, ages as IB a)
aad ages 0-1 yr
Bat a available for seltlple doses.
S.edU. calldrea. ages 1-15 yr
laalgeslc effect disappeared at
«6.3-«2.7 ag/al.
DIV63; DBOG TBTBlpy; tBllGESICS;
piis5iri«"mBi! snBHi BIOOI)
- — •-• 	 	 	 .

BEFEBEBCS
Staaski. O.R.
Sreeablatt, D.J.
LomnstelB, E.
Clinical Pharaacology
ud Therapeatics
2* (1): 52- 59





_
Dahlstros. B.
Bolae. P.
reychtiag, H.
woack. G.
Paalzo*, I.
1979
Clinical Pharaacology
ana Therapeatics
2€(3):35»-365






                                                                                                                                                                                          Ui
llCOtlM (« CIt

SJ!"!?" 3'"''**fcTl-2-"E«Ual«TH-. (S>- (9 CI)

C10-B1»-»2

.. H..II. « <-eo c. BP 2,7 e .partial d«o.P) .t 7« .. „. 123-,25 e .t ,7 ..
TIS19B
<932
Blood
BXPOSnS BOOTE
Inkalatlon
kBURIClt
BETHOB
"
Badioaetry
BOSBBS 	
or c»sss
•1 6
b) 1
                                                                 a) 0-66.a «g/i
                                                                 b) I.S-K.a
                     a) 21.18 «?/l
                     b) Bot applicabU
                                                                                      (BEIT P*SE)
                                                                                                                             QEBIBtL IlfOMlTIOI
                                                                                                                     b)  1«»n,  IkC-cotlBlse level  10-60 «in
                                                                                                                     after  saoklng began.  Kxceeded
                                                                                                                     nicotine  levels at 30 and «0 Bin
                                                                                                                     tata OB arlne and feces levels also*
                                                                                                                     29-60  TT  old habltnal snokers.
                                                                                                                     Itstalned frcs sioklng fros sldnlgtt
                                                                                                                     ptior  to  stvdy.

                                                                                                                     0-13 beats/Bis Iscrease  IB heart
                                                                                                                     ««t«.   Carbozyhesoglobla increase!
                                                                                                                     fros 2.9« to «.«2%.
                                                                                                                               lirnoiBS; SBOKIBS;
                                                                                                                     IIlsO    SDOII:  BIOCDI  HBTIBOlISBj
                                                                                                                                                                    SEPEBEBCE
Irnltage. i.
Bollery. c.
Roasesaa, T.
Kehner, E.
le»i», p.j.
Turner, D.
1978
Clinical Pharaacology
and Tketapeutlcs
23(2):1*3-151
-------
  •933
  Blood,
  plan*
  Blood.
  plasaa
 • 935
 BlOOl.
 plana
 «»36
 float,
 plama
«937
alool,
plant
»93i
              lahalatlOB
             XaaalatiOB
             InhalatioB
            XaaalatioB
            iBhalatin
             Bhalatioa
                              m
                              sc
                             Hm
                             GC
                             m
                                                  11
                                                 10
                                                 150
                                                 11
 a)  lot applicable
 b)  Hot applicable
 a)  9B.«-286.7 aeol/1
 b)  52.4-326. 6 BBOl/1
 C)  2». 7-77.1 BBOl/1
at 10-30 B9/al
b) «-22 Bf/Bl
                                                              3-63
a)  lot «iT«ii
b)  tot gl««B
 »)  6.5 +  oc -  1-«

 b)  9.9 +  ot -  2-2
a)  1*S.« * or - «.0
BIO 1/1
b)  180.0 « oc - 90.0
BBOl/1
cl  52. » » or - 17.3
mol/1
                                                                                                         «.13
a) 1».25 * or
_ — y_l

b) 13.0 » ot - 7.07
M/Bl
                                                                                         19.5 nq/il
a)  252 » or - 1M
B,/15 alB
b)  25«7 « or - 122*
nq/15 Bin
                                                    SBOKIfSs •»»""'

                                                    g^
                                                    BII1FOS
a     r.> -—  «- »
•in
H.bit«l neton, .««»  20-39 T*. »"«
had aot sao1t«a «IBC« pt«»io««
«i«nlaq.
SMICIIG; ncennt wiiccos: jinn
BUMS:  »OTMS8 BtOOD Pl»SB»
i
|  natsnyaaa.
                                                                                                                                                         CJ
                                                                                                                                                       , an
                                                                                                                                                       j pt i|ts-
                                                                                                                                                       1
                                                                                                            25(5
                                                                                                      S«
                                                                                                                  „  S.3kl., ...al br.Bd. 10.7
                                                                                                                                                 ,7

                                                                                                                                      5 hr

                                                                                                                 Stokers, raqlaad

                                                                                                                 B«ITEB KI»5DOg: IMlMs BLOOt
                                                                                                                       »
                                                                                                                        : TOB»CCOS
                                                                                                                 20-39 »r aU «o*«. 1. flood health,
                                                                                                                 Baiit*lBi»
                                                   •  sMMdWl*  ItlCGTTWs  TCBICCOS * JXc»w5
                                                   \  Inm VOTtlS! BIOOB TUSHl
                                                                                                                                                        1

                                                                                                                                                        -
                                                                                                     pharBacoloqr
                                                                                         I
                                                                                         I
                                                                                         t
                                                                                        _l
-------
 BlcOtlBO (S CI)
C10-B1*-B2
BB 162.23. BF <-•» c. BP 247 C (partial decoap) ,t 745 aa Rg. 123-125 C at 17 aa Bj. n , .. „„ „.«,,„
TISSBB
4939



4940
orln





BXM3VBS BOOTB
iBkalatioa


"
iBtalatlom





IBUYTXCll
oTTBOO
_
III


-
CC




.. 	
BVBBSS
or CISBS




so





(COVT
11BCB
•) 1.0-2.8 ao/24 kc
b) 0.6-2.1 Bg/24 kc



lot giToa





IBDED)
BB1B
•I 1.7 * or - 0.84
•9/24 kr
b> 1.78 » or - 1.02
•9/24 kr


133 * or - 19 (SB
aq/100 al






SEHBIL iBrosBtnoB 	 —
•1 9 days oa 22.5 * or - 6.34
M » Says OB 27.25 * 51 - ".5** **°h
ciq»ratte«/a«T. o.«0 mo BicotiB« each
20-30 TC old aaoker* IB good haaltk,
aaUtalaloq aoraal saoklnq habits
StCnBS; BICCTIBB; BLOOD PI1S81-
1QBICCOS; COHfraVaTITB BTAlniTTna^*
IMITS; BMOCIOBIIS; BMBI
SaBdoa saaplea. Bo correlation with
dvclarol naabac of clqarettea saok«d
n _
I « » * *tteB.alBq iafarctiw
ItULTS; BE1PT DISWSBS; OBIBB;
SwaSSJ'1!? mi«w»BS: BEiSOBEBBBT
IHS™ ' "ICCTI*1! BlTaSOlITISs
SDVKIV3

BBFBUBCB
Bill. P.
flarqaardt, B.
1980
Clinical PharaacolooT
•ad Therapeutics
27(5):6S2-658


_
IllCOZ, B.G.
Haqhes, J.
Bolaad. J.
1979
British Bvdical Journal
2 (6 197): 1026-1 021


	 	 	 J
«a.3B-I-03
It 13».7«. n 110 c U.co.p) . B? tecoip to S.203 at 200 C
rani
4941
Blood.
Plena
4942
Otlae

EXMSVU BORS~
_.
01


tBatRIClL
1BTBOD
Coloriaetrr
•
	 — __
Coloriactrr

BOBBSB
or c»sis
M 2
hi 2
-
8

SIMS
— ____
•J 68-9.0 llg/Bl
b) 30-2.3 ««/•!
15.0-71, n of dOM

BEtB
-
M Bot sirea
b) Bot qiren
lot glT«B

CEBIBII IBfOBBHIOB
•» roso of 600 a,/aq B. IT
t) DOS* of 300 *q a, IT
Initial aeaaarea«Bt and 24 he after
latlaatet froa orank
DBncS; CBBflOTBBB&PT: BBOfLkSBS; 9LOOD
BTT1MTS; 01SB&SBS *
	 	 	 	 	 	
30C-SOO aq/aq B
J5"I!.Ir.01* C«><*E P»tl«at». »t
57.3-90.9 *q
B»BSS; CBCBOTBSBtPT: «EOPLlSiS- BLOOB
J""»s WIBU umisi oittum
«IT»»T«S; DISMSBS
	 •- 	
BEKBEBCE
Ball. S.B.
Toang. K.
Ben]aBlB, B.S.
Stevart, 0.
ValdiTl«ao, B.
Bolikiaa, ».T.
loo, T.I.
1979
Cliaieal Phanacology
aad Thenpeatica
2S(1j:*2-87
Ball. s.v.
Tonag, S.
Bealaala, U.S.
Stewart, p.
Taldl*l«so, n.
Bollklaa, l.T.
loo, T.I.
1979
Clinical Phanacologr
aad Therapeutics
2S(1):S2-87

-------
     litrogeu
     7727-37-9
     II
     »t» H.0067. « -210.01 C, BP -195.79 C. TP 3« at a at -1*6.9 C
TISSUE
»9«3
flrine


EIPOSOBE EOffTB
Ingestion


llalTTIClt
BBTBOD
Chea


ins BIS
OF C1SSS
19


| RUSE
I
1
lot given


nut
7.6 » or - 1.6 g/4ar


SIirSIL nFOSfllTIOft
Expressed as teaa of 59.3 9
protein/day. Data fro* «7 7-day
experisental periods.
University stndenta and employees, a
nurse and a teacher. fnlliparons,
ages 19-29 yr.
ill sebleets In positive nitrogen
balance.
TIR*:SS:E: nji»E; IBOII; CIICIDI;
BIGBESITSs IMWatS: PHOSpaOBBS;
OtSIS; RIKEtll BETIBOITSB: PFEC!H»CT
BEFEBEBCB
Ishe, J.8.
Schofield. F.I.
Grsa, B.B.
19T9
Aaecican Journal of
Clinical littritioa
32:286-291


   Iltroglyeerin  (8 CT|
   1,2.1-Sropanetriol, trlnitrate  (9 ci)
   5?-63-0
   C3-B5-B3-09
   Sf 227.09, SP 2.8 C (labile), 13.5 C  fstable)
| TISSB!
1
I
|
f I9»«
1 91ool
I
1
1
1
1
1
1
1
| ETPOSDRE BOUTB
1
1

1 Incest Ion
I
1
1
1





1 mimcm
I 1ETHOD
r
I GC-EC
1
I
1


|
1
1
t
1 BOH BBS
I OF C1S5S
1

a) 10
b) 10







1
| I1IGE
1
|
I a) 0-0.3 ag/sl
I b) 0.1-10.0 ng/al



1
1
1
1
1
I BEil

a) Not applicable
b) Rot applicable








1 GBHEBiL IIFOSgiTIOS
1

I a) 9.S-H he after 7.5 »q
I mstained-release dose. Vone
I detected at E hr
t) 0.5-« tr after 10 19 sastained
release dose, lone detected at 5 hr
Cardiac patients

ISR1EI: DISIiSTS; HII8T DISElSBSi
BIOOB; DBOG 1HMIPT: BBTSS

SEKRMCB

Girant, I.
Salaac, F.G.
1978
Ezperientia
3«(5):«U-64«





                                                                                                                                                                                                00
Oftocin
«0-5S-6
C«3-!M«-I12-C12-S2
t\ 1007.23
TISSfB
• MS
Blood.
plasna


f.WOSOE* ROOtE
Tnvestion


alitTTIClt
BET BOO
Bit


•OHMS
OF C1SES
13


B1RSS
a) 1.S-10E.9 M/al
b) 27.5-181.3 pa/1
c) 0.2-9.9 po/nl
d) 2».5-31.5 pg/«l


l!ll
a) Rot g ire a
b) Bat given
c) Bat given
i) Hot given


6en
O and 1) range of neans
9oaen betireen 35 and '0 vk gestation.
flealthv 20-59 Tr old ten, lit 55-70 kq
D8HGS; »S"1«1»CY; 8100B PUSH;
CCHP»H!ITI»« HltOiTIOHS
| BEFEBEFCE
1
Darood, I.T.
Tlilcarkala, O.
Fachs, F.
1980
American Journal of
Obstetrics and
Gynecology 138(1) :20-2»

1
1
-------
c-aeetophenetidiae  (8 CI1
leetailde. «-(0-ethoiyphenyl)-  (9 CI)
€2-911-2
C10-H13-B-02
H 179.21, HP 139-135 C

1906
Blood,
plasaa
4917
Blood,
plasna
»9»8
Blood.
plasia
«9»9
Saliva
W50
flrlne

Invest ion
Ingestlon
Ingestlon
In 
-------
   ehenothlaziie, 10-f2-t1-*etkyl-2-plperiaTl)«tliYl»-2-(aethyltU,o}-  (8 CI>
   10H-PfcBnotki»zlne,  10-(2-C1-«et»yl-2-piperiainyUethyl)-2--
   50-52-2
   CZ1-B26-B2-S2
   •I 370.56. BP T2-TI C.  BP 230 C at 0.02 •• Bg
1ISS1B

MSI
Bloat,










KTPOSQYS BOOT!
.
T&g«stloa










1HLTTICAL
ttCTBOfi
Che..
Finer o»et rj










IOHBKX
OF CaSSS
19









-
UB6B

1100-»000 ng/nl










SMI

lot applicable









-
etiiui IIFOSUTIOI

Ifter increasing doses of 1-10 ng/kg
e«et 9 >k
21-65 yr old psychiatric patients

la correlation betveen plasia levels
and clinical affects. Plasia levels
correlated «ltk dose.
S1EDBB: aDIJITS: IERTOUS SYSTEM
DISEASES; BLOOD; BLOOD P1»SB1; DBOC
IZEtlPT; TailQtJIlItraS; COBPIRHITE
iniffiTioiiSi punos
i
IETZBEICE

B«rgllng, E.
Bjornaal, I.
(Ireland, t.
Papp, ».
(old, S.
ms
Journal of clinical
Pharaacologr 15:178-1»«





Pkenotklizim. 2-chloco-ia-|3-(dl»ethTla«in«)pcoprl)- («
10B-?fc««athlaliB«-10-prop»n«aln«, 2-cklora-l,l-4iMthrl-
SO-53-3
CTT-B19-C1-B2-S
                                                               CI)
TISSUE
BlOOl,


!iPos»B! tours
I.,esti.n


a*lLRIC*l
HETBOD
QC-SC


ffOIBEB
Of CISES
a) 10
b) a
c> •


M«SB
a) lot gives
b) Bot given
c) lot given


BE1I
at 8.0 * or - 2.3
b) 13. S * or - 2.7
ng/sl
c) 20.3 * or - 2.3


6BBM1L IBPOBBlTICI
a) 0.8-3.0 sg/ka/day
c) 6.1-11.0 sg/kg/day
•-1S yr olds iltk psychosis, lental
retardation or schizophrenia
Siae effects: salivary drooling.
drossiness. urinary incontinence.
tlld seizures, sedation, withdrawal,
lild treiors, rigidity. Inproveient
in target syiptons at plasia levels >
30 nq/il (op tia» «0-*0 ng/il) .
CBHSS: BSOG TREBIPT: 51000 PUSH:
CBTLDIIW: B!B TOBH; BMT1L
•TTIBDITIOB: IEBV90S STSTE1 DISUSES:
BfBBOlOSIC BlBirESTaTIOWS
BEFEBEVCI
Rivera-Caliilli, L.
erlesbach, P.E.
Perlintter, B.
1979
Clinical Pharmacology
and Therapeutics


Iktlialazine, 1-krdrazino-  (« CI)
1(?Bl-Pktkalazinone, krdrazooe  (9 CI)
e€-s«-«
C8-H8-M
BI 1«0.1«. ft 172-173 C
TISStT!

»9*J3
Blool,
plasia










\
\
1
!XPOSOm 5OOTE

Tn lection














•
ABILTrTCal.
BETBOB

BP1C














t
B1SBM
or cisss

2














i
11 BSB

a) 0.02-0.9 UB
b) 0.02-2.8 vB
c) 0.8-1.9 nB
4) 0.6-1.2 OK











1
«E»»

a) Bot given
b) Bot given
c) Vat given
d) Bot given










1
I
GEtmt IirOENaTIOI I (ZTEREBCE
1
1
1
a) Sapid acetylator I Hidden, T.I.
b) Slo* acetylator 1 Shepherd. l.B.B.
e) Bydralazine pyravic acid kydrazone 1 BOay. J.I.
(aetabolite). rapid acetylator 1 tin, B-S.
d) Bydralazine pyravic acid bydrazone | 1980
(aetabolite) , slow acetylator 1 Clinical Phanacology
Itter 0.1 ag/kg IT as hydrochloride 1 an! Therapeutics
txtiiated froa graph 1 28 (M : 736-7*2
1
Hypertensives in TT I
1
1ITIS; UDOllS; BT»»5T?1SIOI; BtOOO 1
ELiSflftt aBTIBTPrHTElSIWS ftGBBTS; I
1 CC*91*\TTTI ITHITUTIOHS: BSTIBOITSB; 1
I «W»BOtTT!S 1
1 1
-------
fhthalallne,  1-nvdraziao- f8 CI)
t(2B)-Pktkalail«<»«,  hydraxow  ft  CI)
a«-54-«
C8-B8-I4
If 160.18. IP 172-173 C
                                                                                       (COITIIOBD)
TISSUE
MS*
Urine

EinSOlE BOOTS


1B11TTXCA1.
METHOD
oc
EPIC

BOHBSB
OF CISES
a) 29
b) 18

MICE
a) 8.0-11.7*
*) 10.4-1*. 1*

Rill
a) lot given
b) lot given

GEBZm IirOSBlTIOI
a) 2* hr excretloas (including
aetabolltes) after 50-150 sg/day
t) 24 hr ezcretians (inelnding
netabolltes) after 200-300 sg/day
Slow an* rapid acetylators
Hypertensives, United Kingdos
tcuus; BTBBBTZirsios: roiiB;
»1TIHI?MTE»SIVE aGEBTS; 0196
THIiaCT; ItllBOLXTES
BSFB8ESCS
TUbrell. J.I.
Rarland, S.J.
FaccklBi, T.
1981
clinical Pharnacology
an! Therapeutics
29 (3): 237-3*3

•iperaTlne.  1-(»-aninc»-6.7-dlnetl>oxv-2-«i»inazolinyH-4-(2-f»roil)-  (8 CI)
Mperaziae.  1-<»-aniwi-«.7-disetliozy-2-«.alnazolinvl)-4-(2-fara.nvlcarboiijlJ- (9 CI)
 1921*-56-9
 C19-H21-B5-04
 n 382.*2, SB 278-280 C
1ISSDI
MIS
Blooi.
Tlasaa
I
•956
Blooi,
plaaia
posnm BOUTS

Inq«stlon
HHLTI3C1L
S FT HOD
HPLC
laoroa«trr
HP1C
IOTBJX
or cms
7
7
HTCS | RSI* 1 GEIIB1I IIFOBRtTIOl
1 1
1 1
1 1
a) 8.6-3.2 ng/al I a) lot given 1 a) 5 control*, 3 and 8 hr alter 1-2
b) a.3-1.9 ng/nl 1 b) lot given I *g, single 4ose. 5.9 ag/nl at 1 hr
e) 12.3-1.3 ng/il I c) lot given | H 12 renal fatient*, 3 ana 8 he
1) 6.7-0.8 ag/nl 1 9) lot given t afttr 1-2 *j, slnqle Jose. ». 1 nq/ml
e) »2-18 ng/nl 1 e) lot given I at 1 hr
f) 3»-» ng/nl 1 f| Cot given 1 c) Controls, 1 an4 10 hr after 3-8
1 1 «q/4»T at steadv state. 1.8 nq/nl at
» 1 0-hr
I I 4) Benal patient*, 1 and 10 hr after
| 1 3-8 ng/dar at steady state. 1.2
I I ng/al nt 0-hr
1 1 e) Controls, 1 and 10 hr after 9-20
I I ao/da? at steadv state, 31 ng/al at
1 1 0-hr
1 1 t) lenal patients, 1 and 10 fcr after
I I 9-20 eg/day at steadT state. 19
1 1 ng/el at 0-hr
| | e)-d), 11 sablects. Xstinated fron
( I graphs.
1 1
1 1 21-67 vr olds vita hypertension and
1 1 varying degrees of renal function.
1 t
I I lovered Hoed pressure
1 1
I | ernes; 9*ne iBBtm; KIIIEI DISUSES;
1 | BTPERTIHSIOl; SIOOO PBESSTJIE: BIAOO
1 I tllSRl: COHP»S»TIT! MHH1TIOSS;
I 1 ItOlTS
1 t
a) Bot given ( a) ».0 * or - 1.4 la) 1 ng dcse
b) Wot giv«tt I ig/nl It) 1 ng dos« * 80 ng propranolol
c) Bot given I b) 4.8 * or - 0.8 I c) 1 ng dose * 100 ng prinidolol
1 ng/nl 1 (eats
1 c) 2.7 » or - 0.7 I
1 ng/nl I Healthy, nornotensive 25-35 yr olds
1 1
t 1 UUtTS: B1CCD VlKHt;
I | »fTIFTP!BT»»SIV! jr.ETTS; DUG
1 | IRCBICTIO*
I 1
tlFESEBCE
oxenthal. D.T.
'obbs, D.
ffrise, R.B.
«oeey. T.I.
artinez, E.(.
Oaesti. e.
1980
Clinical Ihamacology
and Therapeutics
27 (6): 779-783
Elliott, B.I.
IM, r.
Snsner, D.J.
Hera llth, P.I.
Fell, J.I.
1981
Clinical pharaacology
an 4 Therapeutics
29 (3) l 303-309
                                                                                                                                                                                               N)
-------
        e, 1-(1-pb«aylcyclofc«yl)
77-10-1
C17-B25-1
B« 2B3.3!,  «f »< <
   plasia
   M59
   Blool.
   viol*
  Brain
  Heart
  Kidney
   :.  BP 135-137 C at  1 •• Bg


BIPOSOBB BOTTTB
                              sc
                              OC/IIS
                             9C
                             ec
                                                 IS
                                                 SO
                                                             10-812 »9/l
                                                             10-180 ag/al
                                                             lot a«*«et«a-12.»00 ag/a
                                                            0,050-0.060 og/g
                                                            0.060-0.190 ag/«
                                                                                       ,35
                                                                                       73  3 ma/ml
                                                                                       .Ot
                                                                                       not
                                                                                 	l^_
                                                                                 (1KI PWM
                                                                                                                                   I Bailey.
                                                                                                	                                1 Shan  -

                                                                                                a;rr..?9^.trpb..cyriiai^.si.r.a s

                                                                                                B^rSW-S-S*. ? car
                                                                                                •cciaent.  1 «lciae.
                                                                                                                                                  .
                                                                                                                                                  joaraal of .nalytical
                                                                                                                                                  £"™lo,T 3:235-237
                                                                                                             cuiTOBti*:
                                                                                                                                  MOOD: BRM»:

                                                                                                                       »UTOPS1«S
                                                                                              ! BBtisSi  nane  »B«SB, if THBO UUTSXS: I
                                                                                              i SWOB!  BIOOD —««                  '
                                                                                              I	_i.

                                                                                             "t                                     I Claray.
                                                                                              I                                     I Crarey.
                                                                                                                                                           eh«iattT
                                                                                                            |  attrlbatad to araq.

                                                                                                                         MBITIBS:  BIOOB8 BSU«S
                                                                                                                                                 3:235-237
                                                                                                            1 C»1ITO*»I»1  C»»«BS! M.COB:  BSHi;
                                                                                                                                     I Bailey,
                                                                                                                                      Sfca», -
                                                                                                                                     i
                                                                                                                                     i

                                                                                                                                     ! ?oS"io,; 5^34:537-
                                                                                                             1 ilBICIira: aOTOPSlSS
                                                                                                                                                                               N5
                                                                                                                                                                               N5
-------
Fiperlllne,  t-(l-pbenylcrclohexyl)-
77-10-1
C17-B25-1
If 2*3.38. IP 46 C. B? 135-137 C at 1 •• Hg
                                                                                      (CO«TI>VEO)
1ISSVE

4963
liter









4964
tang








EXPOSBBE EODII






















«IIirrlC«t
BET BOD
6C










«c









•raBBB
or CASES
6










4









BIKE

0.028-5.100 ug/g










0.090-0.640 ag/g









IE* I

lot given









_
Bot gir«n









6E1TEB1L IIFOB91TIOI

Eese anknomi

aatopsies, 18 ft old vonan, 17-26 IT
cia ten. Death pheneyelidlne-Eelat«a
bat not attributed to Iraq. 3
hanicides, 2 Sr«g OTerdoses, 1 car
accident. 1 soicHa.
CailTOHlIk; ClDftTZBS: BLOOD; BR»I»;
KIDIZTS; 1TT1S; WIGS;
BIOICC01UL»TIO»: 9BOS iBOSI; fOBEISIC
HZtlCIlE; JOTOPSIIS
-
tese nakaovB

latopsies, 11 yr oil vocan, 17-2* Tr
oH «•». Death pheacrclldine-relited
knt not attritrat«4 to druq.

CtllfOSUta: C1D1TE8S: BIOOD: BSklll;
KIDIETS; iiTti: mes;
tlOlCCQSDtlTIOIt; OBOS iBOSI; FOHCTSIC
1IDICI1S
BEFEBEBCE

Ball«T. O.R.
Shaw, H.F.
EobinsoB, P.I.
Cuba, J.J.
1979
Joaroal of Analytical
Tolicoloqj 3:235-237




Bailey, D.I.
Shaw. R.F.
Pobinson, P.T.
Gabaf J.J.
1979
Journal of inalytical
Toilcoloqy 3:235-237



 t Iparidln*.  3- ((1,3-b«niodioiol-5-yloxT> »«tayl) -*- («-f laoroplwnyl) -,  trans- (-) -
 t1B6»-08-7
 C19-B20-T-I-C3
 II  329.39
K3
LO
1ISSBB
• 965
BlooS.
plasma

















•irosom IOBTE
Tnqestlon



















1»»ITTICH
RETBOD
QC



















HJBB!S
OF C1SES
6



















BUG!
a) 1-11 ng/il
b) 19-47 ng/al
c) 55-106 nqAil
d) <3-8 ng/d
e) 8-37 ng/al
f) 35-86 ng/al














B:IB
al 7.67 ng/«l
b) 33.7 ng/il
c) 72.0 ng/al
1) lot gl*e«
e) lot given
n Bot given














GEBtBIl IBFOBB11IOI
a) PeaVs, 0.38 ngAq
c) P«a\ir 0.77 agAq
c) teaks, 1.14 ag/kq
a) StealT state, 0.14-0.18 ag/kg/9aT
e) Steady state, 0.34-0.45 iq /leg/day
f) Stealy state. 0.68-0.89 «g/ltg/aay.
(2 sublects)
Single-4os« stady («-c) , 3 cases.
peats at 2-8 hr. laltlple-dose study
(d-f) , 3 cases, steady state reached
< 1 
-------
 PlperlftlM,  3-lt»-«ethorypheiK«y)«ethyl»-1-sethyl-»-phe«yl-. (3H-tr»»s)-

 5S8S9-S8-*
 CZO-«25-B-02
 If 311.»S

1ISSWS

Blood,
plasaa






«9«7
Vriae








EIPOSOBE ROUTE

Ingestlon
Injection






Ingest Ion








IBalYTICal
HRBOO
sc






ladioaetry








tOIBSB
or casss
•1 '
b) i






2








Bal6<

a) 40-3.5 ng/al
b) 55-5.8 ng/al






a) 61-8 K of
radioactivity
b) 3-7.2 ag
c) lot given








RCtl

a) fot applicable
b) lot applicable






a) Bot gives
b) Bot given
c) 0.0*2 ag










a) 5 aln and 27 hr after 20 Bin If of
2*. 5 eg. continuous blexpoaential
decliae
I) 3 Bad 50 hr after (00 eg, oral.
Initial valae, »1 ag/al at fl.S hr.
Bealthy volaateers oa BO other dregs.
lealting 1.5 hr after SOO ag dose.
DBOGS: HST1BC1ISB; »KIDEPSESSITE
I6CTTS; BtOOt PUSH; CORP*B1TITE
lYUVmOfS; BSTIBOtltBS; OKlBI
a) cnsvlatlve ercretion op to SO hr
after «»0 eg of 1*C-labelled drag.
lost as eetatolites. laoant
iadepeadent cf arine acidity (pB
*.f-7.9)
b) Is fesoxetiae, pH 4.8-5.3
c) ts feaoietiB*, pB 7.2-7.9.
Healthy 37 yr olds, BO other dregs.
Toaltiag 1.5 hr after COO ag dose.
mass: siTitciiss; IBTIOCPIESSIT:
1GBWTS; BIOOD P11SII1: COHPM1TITI
It»initIO»S; HZT1BOIITJS) OBIWB

~ nrzB2Bci


IMd, J.
Christeasea. J.I.
Beehgaard. (.
flolaader, L.
Larssoa, B.
acta Pharsacologica et
foxicologlca 44s 177-184




land. J.
ChriBteasen. J-»-
Bechgaard, I.
HolBBder, L.
larsson, B.
1979
acta pharBacologica et
Toxicologica 4»s177-1«4






                                                                                                                                                                                            NJ
PIati»a, dia»ai«edichloro-, cia-  f8 CI)
tlatlaaa. dlasBlBedichloro-, (SP-«-2J-  (9
C12-H«-M-Pt
lit 300.01;
tlSUB!

«««e
BlOOi.
plasaa







«9««
giool.





EXPOSOSK BOBTI

In lection







iBlectioB





---
aminictt
ISTWD
us







us






10R8ES
or cisis
8







1








a) 30.*-13.3 iaoles/1
b) lot givea







Rot applicable





IIITT


a) lot glrea
i) 1.S + or - 0.6
moles/1







8.69 ag/Bl





PIG1)
| GEIMiL IBPOtHTICI

a) 1 aa4 B hr after start of 1-hr IT
of 70 ag/sq a. Biphaslc decline
b) 21 days after 1-hr IT Of 70 eg/so.
•
Icn-protelB-Boand Pt < 0.5 aaoles/1
ty 45 hr

Patients vith breast aad ovariaa
carciBoaa, with aoraal renal and
hepatic fnactloB.
tSUSS; CHEBOTBBB1PT: ISOP1JSBS; BLOOD
iiisifii npltff: PHT1WB
_T 	 — 	
it ead of 15 aia IT. Bose, 17S ag
(100 ag/84 a). BiexpoBential
d«elt*e.

a« yr 914 «ith ovariaa
aJenocarclnoia.
MOSS: ciMonretm: PIITIIOB; BIOOO
titsiii: RtopiisRs; atniSi cwcmoits

BIFEESHCi

Goraley. P.!.
Bull, J.R.
leEoy, l.P.
cysyt. B.
1979
Clinical Pharaacology
and Therapeutics
25(31:311-357




Tenorkea. J.E.
ran der Tijgh. D.J.F.
Pinedo. H.B.
1980
Research Cosaanicatlons
in Cheaical Pathology
and Pharaacology
28 (21 '. 3 19-3 28


-------
Platlaaa,  dlauinediehloEO-, ci«-  (8 ci)
Platlaia,  diassinedirtloro-, (SP-»-2|- (»
1J««3-27-1
CI)
C12-B6-»2-Pt
Rl 300.05
                                                                                      (COITXVffED)
TISSUE

4970
Brine








4971
Brine








EIMSUn BOOH

Injection








Injection








iMtTTIClL
a ETHOS
us








cc
us








IBBBSS
OF C15S5
8








1








MI6I

2-23.5* of dose








21-0 nq/nl








nil

lot given








lot given








GEimi nvciiiTioB

B«an cnnvlativw excretion 0.5-24 hr
after 1 hr IV of 70 nq/sq n. 1».8«
excrete! bv 2 hr.

Patients vith breast and ovarian
carclnona, vith nocnal r«aal an4
tepatlc function .

OITieS; CIZBOTBEIaPT; MOPHSBS; BLOOD
E11SH1? UBIVZ* PL&TIVQ1
S and 50 hr after start of 6 hr IV of
131 nq (V aq/sq n). Initial
•easnrenent, 3.4 aq/al. SatinateS
fion qraph.

lestienlar cancer patient, Barvland.

piiTinx: nzTais; DKHS THZIIPT;
CBZBOTHERaPT; B10PLJIS11S! QBIVES
RlBTlalD: *ZlSDSt!tEIT SBTEODS
BEPEIIVCE

Gornler, P.I.
Boll, J.H.
LettOT, A. P.
CysTk, B.
1979
Clinical Pharaaeoloqr
and Therapeutics
25 13) : 351-357


tetoy, ».?.
Vehlinq, I.
Cornlev, I.
Eqoria, H.
ostrov, s.
Bachar. V.
viernik. P.
1980
cancer Treatnent
Teports 64(1): 123-132
 fctassina:
 •>a
 I
     39.098. IP 63.2 C, BP 765.5 C, TP  100 an  Hq  at 590 C
                                                                                                                                                                                             ro
TISSOS
•972
irlae



IIPOSORE BODT5
Taqestloa



i«»inie»i
BETHOD
Plane photonetr?



lUBBIB
or cisss
12



sues
a) 12.3-56.0 a!q
b) 19.6-61.9 aEq
c) «1. 6-65.1 ntq
3) «1.«-6«.7 alq



R<>«
a) 43.0 * or - 11. a
aEq
b> *0.6 * or - 11.«
aEq
c) 50.5 » or - 7.6
al
-------
  *tegna-1,4-aien«-3.20-aione.  11beta.17.21-trlhvdroiT-  (8  CI)
  Piegna-1,4-«ene-3.20-dione.  11.17,21-trihydrorv-.  (llbeta)-  (9 CI>
  50-24-8
  M 360. «». n 240-241  C (decoap)

1ISSBE
4973
Blood,
sera*


BTPOSORI B001S
Injection
Ingest ion


1MIYTXCU
HBTHOD
1
EH


HOBBSB
or cisss
a) 12
b) 3
O «
d) 4


S1IGE
a) Rot given
b) lot given
c) lot given
4) 2.200-90 ng/nl


IBAR
a) 198 * or - 9 ng/il
b) 299 » or - 27
ng/nl
c) 761 « or - 177
ng/nl
3) lot applicable

	 • —

a) lean peak after 10 nc"

TISSOB
•97»
Blood,
plasia


EIJOSBK ROOTI
Inject Ian
tngestion


ilAiniCll
BITHOB
SadioeetEf


I OB BIS
or CISES
3


B11GE
a) 2.32-3.49 ng/nl
b) «.2-».7« ng/nl
c) 0.35-1. SS ng/nl
d) 3.86-».59 ng/»l


BEII
a) 2.90 ng/nl
b) ».»5 ng/»l
c) 0.85 ng/nl
a) *. 21 ng/nl



a) rlaniaolide, IT
b) «8eta-OB netabolite after
flnnisolide, IT
c) flanlsolide. Oral
d| «B9ta-OB netabolite after
flanUallde, oral
0-8 hr average level (area under the
cnrv*/t) after 2 ng.
Healthv nen, 68.2-95.9 kg, no other
n«dicatlon > 2 vk.
riDES; IHTI-IITUBBITOBT 1CI»TS:
COFKCOSIHOIBS: SBT»BOIISB;
BtMBOtlTIS: BIOOB PI»SH»; BBIM:
CC»P»»IITITI BTatOaTICSS; iBOITS

BET£B£BCB

Chaplin, B. D.
Rooks, «•» II
Strenson, S.H.
Cooper, S.C.
Herenberg, C.
Cha. *.I.
1980
Clinical Pharnacologr
and Therapeutics
27(3);»02-«13
-

                                                                                                                                                                                          to
                                                                                     ,. ,.  «,
50-02-2
C22-B29-r-05
Bl 392.«5. DP 262-2«« C,  2S8-271 C (Irth  patent]

1TSSOE
Blood.
plasna



'


\
\
\
\
\ .- —

EXPOSOBB BOOTS
Ingestion






1
1
\
\
—\ 	

llALTTICAl
BETBOD
BIl








V
\
—\ 	 	

BtJBBEB
or CISBS
1











B1RGS
a) 0. 5-4.4 ng egaiv/nl
b) 15.5-35 ng/nl
c) 185-38 ng/nl
a) 63-40 ng/nl








I
tirr

BEAR
a) Rot given
b) Rot applicable
c> »ot applicable
a) Rot applicable









E 9161)

1
1 	 _ 	
*) Pretreatnent valaes 1 Baggan, D-B.
t) 10 nin ana 1.5 hr after eight 1 Teh, F.C.
1.5-ng tablets, rinal value. 35 1 Batalia, B.
mynl at 10 hr 1 Ditzler, C.A.
c) 10 nin ana 10 hr after 10-30 nin 1 BcBahon, P.O.
« oVana'lO hr after 12 ng as 1 Clinical Pharnacologv
eliiir. Initial value. 63 ng/nl at ) »»d Therapeutics
10 nin ' * l J
Intinated fro* graph. 1
1
normal 1S-26 It olds. fast«d 1
overnight. '
1
Dines: COH?»BMITS STIWWIOIS; BLOOD i
PtlSSV; TJUIBt; WTltS; H!?i>OLIS8 1

-------
Pr*gna-1,«-cJiene-3,29-dione, 9-flaoro-t1b«ta,17,2t-trikrdroij-16alpha-«eth/l- (8 CI)
rTe«na-1,*-g»a-1,0-dtene-3,20-aione, 9-tlnoro-l1,n-aihjarory-16-aethjl-21-(pKosphonootj)-,  (11bet».16alpha)- (9 CI)
312-93-S
C32-H30-T-08-P
II *72.*«
TISSUE
»977
Bloal,
plisai









KieOSnffE BOOT!
Inlectlon











llURICal
HETBOB
BI1











imiBSS
or cisss
*) 8
b) 8
c) 8
«) 9








BUGS
a) 22.7-78.0 ag/al
b) T7.0-158 ag/al
c) 157-207 ng/»l
d) 6*5-1,217 ng/al








BE A I
») *9.1 «g/*l
b) 117 oq/«l
C) 187 ng/al
d) 896 ng/al








GZIIB1L IITOBHITIOI
a) 0.03 aq/kg dose
b) 0. 1 aq/kg dose
c) 0.20 aq/kg dose
9) 1.0 ag/kg dose
^-intercepts of seai-log plats of
dcxaaethasoae alcohol concentration
»« tiae after indicated doses.

Horaal 18-26 yr olds.
D3UGS: G10COCOBTICOIBS: STIBOIDS;
I1COD P11SR1; IDOLTS; aBTlBOHSB;
ItTkBOlIIES
SCrt&EHCE |
Hare, I.E.
Teh, K.c.
Ditzler, C.I.
RcRahon, F.G.
Hugger, D.S.
1975
Clinical Pharaacologr
and Therapeutics
18 (3) : 330-337



  VxopionaniliOe.  «-{1-phenethTl-»-piperLdTll-, citrate  (1:1)  (« CI)
  tiopaaauide. «-»he«Tl-"-{1-(2-phenTlethIl)-»-piperidlBTl)-,  2-ajdroxr-1.2,3-propanetricarbx»Tlate (1:1)  (9  CI)
  MO-73-8
  C 22-R28-12-O.CC-H8-07
   II 528.*S, 1?  1*9-151 C
ITS SHE
*»78
Blood.
9«t«u







EIIOStltE BOOH
Injection









liilTTICil
HETBOD
Ilk









108 BBS
or cuss
a) 5
b) t
e) 3







Bivei
a) 352.8-8 ng/al
b) 91.6-5 ng/al
c) 55.3*1 ng/al







am
a) lot applicable
b> Kot applicable
c) lot applicable







GE11S1L IirOBRlTIOl I
1
a) 1.0 ug/sq a
b) 0.5 ag/sq a
e) 0.1 »g/sg, a
tinge of Beau, 0-2 hr after dose
•
28-C9 fr olds, vita nearo- or neck
cancer surgery.

DBDGS: OBOG TBSB1PT; BUMS SEBUI;
cnniostint rtaio; asiiii; isutis
nrnEBCE
Schleiier, 9.
Benfaalni, B.
Eisele, 3.
Henderson. 6.
1978
Clinical Pharaacology
and Therapeutics
23<2):188-194


                                                                                         
-------
                                                             .  ^U-1.2.3-pr0p»«tri«rb«Tl.t. ,1,1,  (, CD
   990-73-8,
   C22-B28-I2-O.C6-B8-07
11 528. »5. BP 1»V151 C (COITIBVE9)
*!»«
•979
Cerebrosp
inal
fluid
•989
urine

EMOSSBE 80HTE
Injection
Injection

IMiTTIClL
BETBOD
BIk
BI1
	 —
BBBBSR
OF CIS3S
1
1

B1WGE
0.1-3 ng/nl
tot applicable
Bill
Wot applicable
21 * of dose
GEIEBAL i«rUKB«IiV>«
5 and 30 ala after 1.0 ng/sg •.
final neasmrenent, 1.25 ng/nl at »
BE.
leorosnrgical patients
DBDGS; DBD6 tBZRWT; BIOOD SEBOS:
CEBEBEOSPIBIL FlCWS BBHB; kDOITS
C«e«lati*e excretion in M-hr nrines
after 1.0 ng/sg n
lenrosvrgical patient
OBOGS: DBOG THEBIPT; BIOOD SEBOB;
CEBtBBOSPIBtl FIBIB! USIBBS IDBWS
_. 	 	 — 	
Schleimr, K.
Senfanini. E.
Eisele, 3.
Henderson. S.
1978
Clinical pkarnacology
end Therapeutics
23(2)t188-19»
Schleiner, a.
Benfailni. E.
Eisele, J.
Henderson, C.
1978
Clinical Pharnacology
and Therapeutics
23(2):188-19«
... 	

  propionic acid, 2-rp-c»loroplie»orTl-2-net»yl- J8
  Frcpanoic acid, 2-<»-chloropbenorr)-2-nethyl- C9
  862-09-7
  C10-B11-C1-03
  II 21«.66. HP 118-119 C

tISSWE
• 981
Blood,
pi a ana


EIPOSDBX BOOTE
Ingestion


»»»tmc«i
B ETHOS
9PLC


tmess
or cisis
*


I1I6E
lot giren


am
96.1 * or - 17.7
«1/nl



lean steady state valves, 2 I Iq/day
for « «k.
Bealtkr 22-35 TT olds, no nedieations
for 2 preceding »*.
EiOGS: eturcmii: BIOOB PI»SB»: DSOS
IHBBIJT: »BBWS: CORPIMTITE
tf»lB»TIO»S: BE11BOLITES: CB1OIME
CBSAHC COIPCIIIIDS

BEFEHEBCE

Bjornssoa, T.D.
Reffin, P.J.
Svezey. S.
BlaschVe, T.F.
1979
Jonrnal of Phamacology
and Experlnental
Tterapeotics
210(3) :316-321
	 — —

                                                                                                                                                                                           to
                                                                                                                                                                                           00
Propionitrile, 3-anino-  (8 Cl)
Fropnnenltrile, 3-anino-  (9 CII
151-18-8

£f ToTo!. BP 185 C at 760 nn Hg. 87-89 C «t 20 nn Hg, «6-«9 C at 5  ..  Hg.  50-55  C at  3  n.  Bg

TISSOE

•9«2
Vrine



^

BTPOSJB! FOOT*

Ingest ion





kllllTTICkl
BE? ROD
Photoaetry


\
\ 	 . — 	

BOBBSB
OF CISES
1





8i»G!

Hot given





9E>B

16.3 « or - 0.6* of
dose





GIBIB1L IBTOBBinOB

Steady state excretion, days 2-U on
2?0 »g/6 lir. Brine collected at drag
aanintstratlon.
1< yr old blaclt »ltn nassive *e lo ids
renoved surgically.
WIGS; 99.UG IBSBkPI; OBI1E:
BRUCLISBl BETkBOlIIES; EBITUSS

BETEBEBCE


Fleisher, J.R.
Peacock. I.B.
Ctvapil. B.
1978
Clinical Pharnacology
ana Therapeutics
23(5)i« 29-52*



-------
pyridiae,  2-(alpha-(2-r 1
1
sires
a) 0.01-0.14 ag/al
b) lot gives
c) lot given
Sot given
Rot given
a) lot qiT«n
b) lot given
lot given
HEIR
a) 0.112 * or - 0.062
«g/Bl
bl 1.9 ug/al
c) 30 ng/al
5.3 ag/g
.
4.0 ng/g
a) «.« ng/g
b) 115 ug/g
1*9 ng/il
Givnti nroBunoi
a) 3 Ml«s. 3 f«t*l«s, n«ta »t £7.17
» or - 8.2 Itg. 2 hr after IS «g of
the lalaatc
b) Ivtopsv, It yr oil »al«, possible
o*cc4ose
e) Jutopsj, ** yr old, snlclte
Dunes; DSOS unsi; SUICIDE:
iiriopsigs: cisi BisTOtiis;
«iis»«tliyl)-, hydroxide, later salt, <«B-trans) - ?9 CT)
  iO-59-9
  CW-B17-I3-0*-S2
  ill MS. 50
TISSUS
>988
Blood,
plassa

Ttposns? gonre
Injection

aHLTTICIL
RETBOD
WLC

BORBIB
or CISES
t

BlIGE
a) 32.8-40.* ng/al
b) 0.9-2.6 ag/al
(SETT
HZll
a) 36.8 ng/»l
b) 1.65 ag/al
P»Ct)
GIlEBat IHPOailTIOS
a) If tec 5 iln
t) after 7 hr
Dose, 10 sin IT of 1 g
Healthy 27-*7 yr olds
tBBCS; IMTIEIOTICS; S»EDK; DliTin!;
EICOB pusiu; HDUITS

SEFEEERCE
Rrvldsson, &.
Borga, O.
alvan, G.
1979
clinical Fliaraacology
and Therapeutics
25(«):870-87$

-------
 lyridlnivn. 1-a2-c»rtory-8-oio-7-(2-(2-thi*iiyl) aeetMl4o-)-S-thla-1-aTabicjclo(a.2.0) oct-2-en-3-yl) »ethyl|-,  hydroxide, tuer salt (« CD  (T»»)
 PyrHiBiaa. 1-(f2-carborr-8-oio-7-{{2-tnienrlacetTl|«Bi»oJ-S-thl»-1-a«biciclO'(».2.0)oct-2-en-3-rl) ««t*yl)-, hydroxide, liner salt, (6S-tr»nsJ - (9  CD
 50-59-9
 C19-H17-I3-0«-S2
 R« »15.50
                                                                                       (COITIIDEO)
Tissue
•989
urine





SIPOSOBt BOOTS
In -(set Ion






alaLTlICal
nTHOD
RPLC






IVIBEB
or CUBS
*






IM6I
•at giTon






Mil
_
71 * or - 1OT of dose






SB* Hll I»K»BalIOI
30 hr excretion after 10 »in IT of 1
9

Healthy 27-m yr olds

usffss; iHTrpiDircs; SWBDB»J mire;
EtOOD PLlSai; 1 DOITS
BSKBWCE
IrTidssoa, i.
Bocga. 0.
HT»B. s.
1979
Clinical Fbariacologr
ana Tkerapentics
±5 (6) 1 870-876
_
trriainiiiB, 2-fociTl-1-ietbrl-> chloride, oxin  (8 CI)
tTridinlm, 2-(CBTac«Ti«i"o]«ethyl|-t-iethTl. chloride  (9 CI)
51-15-0
C7-H9-»2-O.Cl
«« 172,«3, 8« 235-238 C (decoap)
IISSD3

•990
Blood,
plasna











t
1
1
• 991
urine
















ntOSHBB B00TB

Tn-tectlon
















Inlection

I















ilALTTICll
HSTHOD



































BIIBBSB
or cisis
6
















5

















B1ISB

at 18-0.6 ag/nl
b) 18-t.D ag/nl















a) «ot given
b) lot glTen
















•Eat | GEIER1L IlFORHaTIOl
J
1
a) tat applicable f at after 5 sg/kg IT. < subjects
b| tot applicable I t) Ifter 5 nqAa * 2.5 hr IT of 100
j ng/hr thiaaine, * snblects
j Bange of leans, 0.05 and «,0 hr.
I Beans significantly different after 6
1 tin
1
I 20-27 yr olds
1
1 Rild to noderate risnal synptons
t lasting 5-10 nin
1
1 rtires; mva HTESJCTIOJI; BIOOD
r »L«SB»: 08111; COWPMlTXTE
1 ITliaHTIOWS; IDOLT5
1

a| 72.4 t or - 3.3? I a| 0-1.5 hr excretions after 5 eg/kg
b> 38.2 * or - 9. Of I IT, 5 snblects. 97.0 * or - 1.0^ by
1 6 br
1 bt 0-1.5 br excretions after 5 ng/kg
1 « 2.5 hr IT of 100 ng/hr thia*ine. «
1 subjects. 75.9 * or - «.6X by « hr
1 1} and b| significantly different, P
1 < 0.001 in 0-1.5 hr excretions and t>
1 < 0.01 in 0-6 hr excretionsi
1
1 20-27 ft olds
1
1 Rild to noderate Tisnal synptons
1 lasting 5-10 «ln
1
1 c^iGS; oias IITEBICTIOI: BLOOD
1 SIIS11: USIBE; CORPtBHTITl
1
BETEBEBCE

Josselson, J.
Sidell, F.R.
197«
Clinical Phatnacology
and Therapeutics
2*(1|;»5-100











Josselson, J.
Sidell, F.B.
1978
Clinical Pharnacology
and Therapeatics
2« (1|: 95- 100












                                                                                                                                                                                           U)
                                                                                                                                                                                           O
-------
                                                               «.
C9-H13-R2-02
HB 181.2*
IISSJE
-
«992
Blood.
Plassa






»«3
Blood.
Sena







EXMSVRB BOOTH

Ingestioa






Tn-fection








SETHOD
8C






GC





.

—
BOBBER
or casss
	 	
i






5








Biiei
2.7-18.* ng/sl






-
a) 700-1800 no/si
bj aO-60 sg/sl








RB1R
lot giren






"
a) lot given
b) Rot given








Giimi iRFOBEitioR
Dose. 60 sg as broaide, 31 daily
flyasthenie patient. U.K.
BBTTSS; 3LOOD PL1SU; BEaSOBZBEBT
RtTRODS; OR1TO KIR«D09



— — — — — ^_^__ 	 . 	
a) Initial Icrala
n) iftac 3-a kr
rose. 2 ain IT of 0.35 ag/lcg «ith
0.03 ig/kg atropia*.

2«-»7 yr old surgical patients »itK
nonal r««al fraction.
B1CCO SIBOH; DRUGS; DS05 TltBHI:
BBttS tRTIPaCTTOR: STI*SE»t


fi£7EBEHC8
DS»i900, S.C.
Preatis. B.».
Dchghan. *.
Chan, K.
1980
H«thoas and Findings in
Experimental and
Clinical PkacaacologT
2(21:77-82
Cronnelly, B.
Miller* R.D.
Sheiner, L.B.
1900
Clinical Pharaacology
and Tberapeatics
2B(1):78-61


Eyridoiol (8 CI)
                        5-hTdro«T-«-««tajl-  (9 CI)
CS-ill-R-03
H* 164.18. BP 1«0 C
 ?TCimiiln«,  2,a-diaalno-S-(3.»(5 .
 CK-B18-H-03
 e« 290.32, DP 199-203 C
TISSTJE j
1
Sil*
1
	 .1
Ingestion
BETROD
Blcroblological
HOBB58
or Casss
-
a) «
b) 8
e» S
BUG!
-'
a) 67-177 ug/1
b) 189- 3«8 sg/1
c) 2S«-«S« ng/1
	 . 	
«S»R
a) 129 * or - 39 ug/1
b) 239 * or - 51 ag/1
c) 31» » or - 52 ng/1
GIRIUt IRFORRITIoi"
a) < 2.5 sg C-6/day
fc) 2.5-5.0 sq »-6/a«y
c) > 5.0 sq B-t/day
Bo effect of stage of lactation.
Healtby. lactatlag 2»-«2 yr olds.
ITIK; Tieilll; TXTimaS; DIMS;
I ICIaTTOR
IEFBBBRCB
«e«t, F.O.
Urfcsey. 4.
1976
Aseriean Joamtl of
Clinical Ratrltion
                                                                                                                                                                                          LO
TISSO!
-
Blool,
Plassa
ETPOSOBE BOOTE

Ingestioa

kRlLTTIC4t
RBTB09
BPLC

                                                      ROBB3T
R1RGE
a)
b)
c)
d)
f)
Rot
Rot
Rot
Rot
Rot
Rot
applicable
applicable
applicable
applicable
applicable
applicable
1BII
a)
b)
c>
»
e)
f)
0.
0.
0.
0.
0.
0.
57
92
6*
36
10
01
vg/sl
og/al
«g/sl
«g/sl
ig/sl
»g/sl
(REW ?4GE|
GCRERll IRFOSfliflOR
a) 0.5 »r
b) 2 fcr
c) « kr
d) 12 he
•I 2« kr
ft as KE
Tlaes after dose of 100 sg
Rcraal sablects
HICflD: BT.OOO P11SB1; OSIRE:
»RTIBIOIICS: BP06SJ CORPIBITITE
HAIOITIOHS; HEaSOEBWlT BETBOBS
1EFEBERCE
Seinfeld, P.E.
Racasleb. T.C.
1979
Journal of
Ctroaatography
1«»:73-8«


-------
738-70-5
   nssvt
                                                                                     (COIfIIOB»)
   •996
   BlOOfl.
   plasm
   »997
   Blood,
   serna
   »998
   K«r flaia
   •999
   orlae
tiposnm BOOTB
Ingestion
Xngettion
InqestioB
I«g«stio«

iJltlTICIL
BRBOD
	 , 	
TLC
Coloriietry
_ 	
HPtC
mix
mix

inasBH
or cuss
i
-
6
«
1

	 BWSB
. 	 . 	 • 	 	
1.95-0.29 «g/«l
•ot gi»«n
-
0.20-2, 7 C •«/•!
a) »ot applicable
1,) »ot «PP"«"«
c) »ot appli SS.O ag
b) 31.7 >4
c> 3.0 ag
4) 89.7 ag

                                                                                                                    O.S and 2-i .r      B
                                                                                                                    «i»«tboprt» and 800
                                                                                                                    stlfaaetboiaxol*
                    BLOOD
IMSUBBMIT
                                                                                                                                           •*»• 20 "/1tg
,-!.? hr after »
s«lfa»«tHoMiole.

2-6 rr olfls «ith chronic serous
otltis sedla.

HIIBTOTICSi
BIOOB SSBOB; si*
                                                                                                                                            CSI1BPT!*:
,-I.S hr after « ag/»g «ith 20
s«lfaaetboxa»le.

2-6 TT ol«s »i*b chronic setoas
otltis »e«la.

                        CBXIBMI:
                                                                                                                     »«ti8io«cs:
                                                                                                                     MOOD SSOTB! «»« fLOID
                                                                                                                     a)  0-2« hr
                                                                                                                     b|  2»-»8 hr
                                                                                                                     c)  |«-72 »r)
                        tl.es  sbo«
                                                                                                                     eose,
                                       Siqel, C.t.
                                       Grace. B.I.
                                       lichol. C.I.
                                       Bitchlngs, S.H.
                                        197«
Ph.r.,C«C.
S3 {I): 1202- «05
Kllaek, 3-J-
Bates, *•*•
nightingale, C.
l«haann, B.B.
Ziemiak, J.I'
Qolntillanl, B.

journal of pediatrics
96(«):1087-toe9
Kliaek. J.J.
Bates. T.B.
•Ightlngale, C.
lehaann.  S.B.
Zlesniak, J-».
Qnintlll»ni. H.
1980
journal of  Pediatrics
96 (6) s 1087-1089
 *einfeld,  B.B.
 facasieb,  T.C.
 1979
 journal of
 ChronatographT
 1S»:73-S»
 26171-2J-
|«. 257.30, BJ
-«5i5B—
1*00
Blool.
plasna





1
1
1
\
\ 	

"CIPOSOBS BOOM"
	 - ,
Imgestion





\
1
t
\
\
\
	 l_ 	 •

	 IWlTTIClt "
KITBOD
RtdiOMttT
H.C





1
1
t
\
\
\
\ 	 —

iOBBBB
or cisss
s




I
I
I
I
t
I
\
\


	 IHGB
a) 31.88-19.26 ag/nl
b) S.21-8.97 »g/»l
c) 3.93-7.11 «g/nl
4J 1.22-2.22 «g/sl




1
1
1
1
1
1
I
1

	 '

a) 38.88 + or - 6.62
ug/al
b) 6.72 + or - 1.W
ng/sl _ «c
c| 5.26 » or - 1-2«
ag/nl
d) 1.75 » or - 0.37
•g/sl
1
1
1
1
1
t
I
\
1



21
tl
t
I
I
1 C
1 1
*
' *
1
1
|
t

                                                                                                                                                             Srlatel, J. *.
                                                                                                                                                             Hlgdalof. S.H.
                                                                                                                                                             Clostnieks. J.

                                                                                                                                                             Cllalcal Pharaacologr
                                                                                                                                                             and  Tb«tape«tics
                                                                                                                                                             26 (Us 122-128
                                                                                                                                                                                      I
                                                                                                                                                                                      I
                                                                                                                                                                                       I
                                                                                                                                                                                       t
                                                                                                                                                                                       I
                                                                                                                                                                                       1
                                                                                                                                                                                       I
                                                                                                                                                                                        t
-------
BTrrole-2-ac«tic acid, l-sethyl-S-p-tolnoyl- (8 CI)
IB-frrrole-2-aeeti.e *="« 1-s*tnTl-5-<«-setarlben«>n>-
2*171-23-3
C15-B15-B-03
BB 257.38. B? 155-157 C  (dec)

TISSUE

5001
nrlne










EZPOSHBE BOUTS

lagestion










IBilTTXCU.
•IWHOD
Sadiosetry
nc










BOBBBH
or CASKS
5










B1BGI

•1 24.3-5.73 ng
b) 191-2*0 sg
c) 2«.3-57.0 ng












a) 32.5 * or - 13.9
sg
b) 216 * or - 18 sg
c) »1.» * or - 13.S









GiBEBii 1 1 retain os

_ 	 — — —
a) Tolnetin
b) Balor setabolite
c) Tolsetln con 1 agates
0-2* hr excretions after 300 ng
C1*-labelled dose
idnlnlstered as sodlvn salt

Patients vith rheenatoid arthritis >
1 TT, fasted before and after dose
BBBGS; »BD6 TBSSlMs JISEISES;
BHZIWTOIB 1RBBITIS;
• 1OTT— TBFLaBBWOBT aGXVTSj BX>OOD
PIIS1U; BETIBOLITES; OBIBE

BEFIBEHCJ


Grindel, J.B.
Blgd&lof, B.a.
Blostitieks, 3.
1979
Clinical Pharnacology
and Therapeatics
26 (1)t 122-128







 fwtole-2-a«tic acid. 5-|p-cl>loEOb«»»Tl)-n»-dlii«tarl-  (8 «»
 1«-?Trrole-2-ac«tlc acid, 5-(*-ehlorobe»*OTl|-1.«-ai»«thyl-  19 CI)
 33369-31-2
 C15-H1«-C1-I-03
 II  291.75
nssn

5002
Blood,






5003





riposora BOOTE

<.,„«,.






Xngestioa





liiiiricaL
BETBOD
BPLC






BW.C





BUB BEX
OF CISSS
2*






2*





iiioi i

a) Bot glren
b) Vet giren
c) Hot gi*en






a) Wot given
b) Bot given
c) Bat given





Bill 1

a) 2.47 » or - 1.15
b) *.*2 * or - 2.2*
c) 7.9* « or - X.07





a) 23.16 * or - 5.87
b) »3.80 » or - 19.55
c) 83.93 * or - 26.95




GSBIBU IBTOBBKIOB

O «ean peak. «* » or - *7 sin after
50 ng
E) Bean peak, 57 • or - *5 nln after
100 ag
c) Bean peak. SO » or - 66 sin after
200 sg
Peaks significantly different, p <
0.0001.
BealthT sales, scan age 2* yr. fasted
> 12 hr.
DB96S; BLOOD S11SB1; 1&01TSJ
miGBSXCS; HBI«S
a) after SO ig, 3»< as vnchanged drog
ft) after 100 sg. 19.3V as nschaBged
a tug
c) after 200 ag. 23. M as unchanged
drag
0-12 hr cnnnlatlve excretion of
unchanged and coalnqated drug.
BealthT sales, ne»n age 2* rr. fasted
> 12 hr.
taOGS: BLOOD PLaSBt; IBOITS;
BEFEBEICE

Bayak. S.K.
»g, K.T.
Gottlieb, S.
Plostnleks. 0.
1980
clinical Pharaacology
and Therapeutics
27 (3): 395-401




Barak, B.K.
Bg, K.T.
Gottlieb, S.
Plostnleks, J.
19 SO
Clinical Pharmacology
and Therapeatics
27 C3) : 395-401





OJ
OJ












-------
«6-5«-2
C20-H2«-«2-02
ia 12*. m. m
ussnE
500*
BlOOl,
plasna
5005
Blood,
plasna
5006
Blood,
plasma
5007
urine

? 17«-173 C
EX MISUSE BO TIT J
Ingestion
Injection

Injection


IB»ITTIC»I
Tluoronetry
ILC
Tlnoronetry
flBoroaetry
TIC
Fluor osetry


BOBBER
OF CiSBS
5
«) 9
b) 8
6
a» »
b) 8


	 itIGE
a) 1.6-3.6 «g/«l
b) 1.5-3.7 ng/nl
a) a. 3-0. 26 ng/1
b) 2.75-0. 165 «g/l
Mot 4lr«n
a) lot qirea
6) Bot gi»en


' »E»»
a) 2.3 * or - 0.7
n
-------
Salicylic acid  (8 ci)
Eentoic acid. 2-hydrory-  (9 CI)
€9—72—7
C7-II6-03
Hi 138.12. tt 157-159 C, B? about 211 C at  29 •• Eg
TISSUE

5008
Biood.
Plasaa
5009
Blool.
Plasaa
5010
Blool.
plasaa
5011
Urine

BIPOSDSB BOOH

Ingestion
Ingestion
Ingestion
	 .
Ingest ion

Amnicii
HBT HOD

BPIC
•
HPtC
8PLC
ec
HPIC

BMBsa

18

a) 7
b) 7
18

B1BGE

a) 0.098-33.1 ng/nl
b) 0.69S-36.5 ng/*l
c) 0.783-37.5 ng/sl
0-55.2 ng/sl
aj 0-7» ng/1
b) 106-276 ag/1
a) Dot giren
b) >ot glTsu
c) Sot glrm

1 	 ————__
HEIR

a) 21.9 ng/«l
b) 22.9 og/al
c) 22.7 ug/»l
lot given
a) lot applicable
b) 1S7 »g/l
al «07 * or - 90.5 ag
b) 393 * or - 69.3 ag
e) 369 » or - 77.7 ig



?j '«« «« »9 aspiria
t) Ifter aei », Bg-sallcylate
c) Ifter 500 a? caoliae
Bg-trisalicylate
leid**1*** °f abOBt ^°° "* salicrli<=
0»ec 16 l>r.
filial £? ?ol"t~"' « «»-« *«.
iissoni; loowsj BIOOD nasiut
J?I«i »!;l6E««i »WI-lm»B!»T08T
BFass COBPMMITB muiTMtss
0 «ai a hr after 1000 ma
MlicylaalicTlic aci«. Clearance by
2* hr. Ijtlaated fro* graph.
SIJ.*!!01" IBBI*S: WOOD H.1SB*!
iiilSEsics; ini-iiniBnioti IG-HTS-
BI1SBBMMT BETBOBS; DOTGS 15!"S>
a) lo.est a»4 highest nlaes o»er 2»
hr following tngeation of a single a
9 dose. ieT«is peaked at 2 hr and
, « ff511'*4- Considerable
indiTH.al variation, dne to
"'Sand'5*9 U •€t»bolls" o£ P"»«»
dUirliL'l,5^ *•! f0110'1'" *-i«
aally dase of 3 g of benorylate.
Bealtliy 21-67 yr oUs. nt »«-100 kg
FBIBCE; IBDItS; BWOOj BIOOD PllSBi-
DMGSJ II fluo HllySIS
' 	 __
Jj «*« «9« ., aspirin
"*«r *81 •« «
-------
salicylic *ei« acetate (8 CI)
BensolC »eia. 2-<«cetyloxy)- (9 CH
50-TS-2
C9-B8-0*
SI 180.2, IIP
5012
Blood,
plana
	
135 C
EXPOSUBB BOUIE
Ingestion

liunicu
METHOD
-


OF CASES
. 	
6

	 Silos
- — ~
a) lot gi»en
bl lot gl»«n

nil
a) 81 ug/el
b) 76 ag/nl

— 	 "etimi HFOSBiiioB
.) Bean pea* at 1 hr. 1200 »g aspirin
t\ Bean peak at 2 hr. 1200 «g * 500
sg naproxen
IstUated from graph. „„-__,.
Irea-«naer-the-cnr»e not different
•it* naproxen. P>0.05.
Healthy 23-«fl tr «!««. fastefl
oiexolqht.
rsnesj Datre nweaicTioi:
MM-iin»Bawosi »GHTS: »BJt«:
flCIS; BtOOD PIIS81: CO«P»S«1VB
IfllVkTXOIS

— 	 MrtBEBCS
	 	 . — . — •
Segre. !.J.
Chaplin. B.
rocckielli. I.
Hankel. B.
SeTelias. B.
197*
Clinical Pharnacology
ani therapeutics
15<«»8i7»-379

Salicylic  acia,  ionf1-1  (8 CI)
Eentoic acid,  2-hydroxy-. ion(l-)  (9  CI>  (T1U
S3-36-S
cl~**?°?.  	  ..,  ,rn ^  «n .hnnt  211 C at  20 aa Bg
HI 13«.t2, «
TISSBS
5013
«lood,
pla*n«
50 1«
Blool,
plasaa
S01S
Blood.
plaava

p 15V159 C, BP a
EIPOSME SOBTB
Tnfe*tion

Invest ion

Boat zii •«• »l «« ••
allirTXCll
NZTBOB

.
-
ColoclMtrr

loissa
OF C1SSS
2

6

	 BUGS ~"
a} »ot applicable
b) lot applicable

10»-157 «4/al
	 • 	 (BUT
iili
a) 25.7 ng/100 »1
b) IS. 7 ng/100 «1

lot given
«aSI)
— 	 SEBBB1L IBFOSBlTICra
a| *«born, ««bllical cord rein
U birt" after «.S -MO
rcaser, D.G.
London. T.B.
iTens, B.P.
Sntherland, E.B.
1980
Clinical Pharnacology
and Therapentics
27{2):16S-1«9

-------
Salicylic «cld. load-)  (9 CI)
Beazoie acid, 2-hydroxy-, ion(l-)  (9 CI|  (MI)
63-36-5
CT-B5-03
it 138.12. HP 157-159 C, BP abovt 211 C at 20 » Bg
                                                                                      (COBTMDBD)
TISSOB
5016
Blood,
plasma






5017
Blood,
seram









5018
Blood.
senm






5019
Blood,
sera*





••020
BlooJ,
seram







EXPOSURE SODTE
Ingestion





.
IngestiOB









Ingestion






iBgestiom





Ingest Ian







imtTICII
HBTBOD

















rlaorometry






colorlietry





riaorosetry







BBBBJB
or cists
a) 1
b) 1
C) 1
d) 6
«> 6






12









7






20





9







81BQE
a) 9-0.2 og/al
b) 20-2 ug/Bl
c) 28-7.5 ag/al
d) 28.8-73.2 ag/ml
e) 54-120 ag/ml






a) 7.13-34.6 ag/100 ml
b) 0.582-6.06 ag/100 ml









Bot given






4.4-33.0 ag/100 ml




_ .
a) 10-26 mg/1
b) 29-58 ag/1
c) 106-181 ag/1
d) 122-236 ag/1
«) 175-286 sg/1
f) 215-292 ag/1






(BEIT
HE»S
a) Bot applicable
b) Bot applicable
c) Bot applicable
d) 40.1 » or - 17.3
ug/al
e) 77 + or - 24 ug/al





_ ....
a) 19.67 » or - 7.62
•g/100 al
b) 2.73 * or - 1.69
•g/100 ml








-
0.53 + or - 0.08
mmoles/1






14.47 mg/1 00 al





a) 15.44 ag/1
b) 44.56 ag/1
c) 147.89 ag/1
3) 189.56 ag/1
e) 243.78 ag/1
f) 254.50 ag/1






P«GI)
6E1ZB1L IBFOSUnOB
a) 0.5 aad 6 hr after 15 al dose
b) 2 and 9 ht after 30 ml dose.
Initial leasorvmeat, 11 ug/al at 0.5
e) 3 and 9 hr *f ter 60 ml dose.
Taltial aeasare*eat. 12 ag/sl at 0.5

d) 1.9 hr after «0 ml (peak meaB
level)
e) Peak level after 60 al/6 hr for 5
doses
8.77 sg sallcyelie acid/al
Bealthy 28-38 yr olds, »t 50-82 kg
• DOITS; BBIBIi BLOOB TUSB1; DSOGS;
IBatBtStCS
*) Total, correlatioa with saliva
levels, r-0.708
t) Free, correlation «lth saliva
levels, r-0.944
Tise-averaged steady-state levels.
nsval dose 8C aqykg/day.
7-17 yr olds with rheamatoid
arthritis.
I»B« TBVK1PT; 1MIGESICS; SatlTI;
BIOOD swan; CHUBSSB: B.MBSMOIB
1BIBBI1IS: Dm.SBS; COMmirfB
miOMIOBS; ILIIBOIS; HBlSBBBnBIT
flITBODS
Beaa peak at 0.5 hr after 900 ag plus
one 6*0- eg sustained release tablet
of phenytoin. 27.4* redaction of
phenytoia IB 2 hr.
Bcalthy 23-36 yr olds. »t 50-80 kg.
ttOSS; DSB6 TBTEBkCTIOB; BIOOD SfBO»:
»t BITS; sum; aBTicoBvoisirrs;
mtGEStcs: IBTIPTBETICS: m
ZtallBt; HEI1BOLISB
Ifter 5 days on 50 sg/kg/day buffered
acptriB in 5 doses.
Bheamatold arthritis patients, ages
20-86 yr.
D10CS; BflnRlTOID lETHHITIS; BIOOB
sisoa: nini; jBBttSs BISEJSIS:
fllTlBOlISH; BITlBOtlTSS
a) 0.66 B4/kg/hr
b) 1.0 mg/kg/hr
c) 1.8 ag/kg/hr
C) 2.1 eg/kq/hr
e) 2.7 ag/kg/hr
f) 3.0 ag/kg/hr, 6 snb-lects
Steady state levels
Scalthy 25-40 yr olds, OB no
aedlcation >2 wk and ao sallcylates
'3 VIE*
rtTJSS; HHTI-HriilHAtOBT 1GIBTS;
1B116ESICS; BIOOD PUStl: PMTEIBS-
OSI«E: C01>P>BITITE ITHLDtTlOlCS:
BITlBOtlSHj 1D01TS
- J 	
SIPEBEUCE
reldaan, S.
Chen. S.-l.
Pickering. L.E.
Cleary. T.G.
Ericsson, C.D.
Raise. B.
1931
Clinical Pharmacology
and Therapeaties
29 (8)5 7 88-792




Levy, G.
Procknal, J.I.
Olafs. B.
1980
Clinical Pharmacology
and Therapeaties
27 (5) j 6 19-627






Pazton, J.B.
1980
Clinical Pharmacology
amd Therapeaties
27(2):170-178




Gapta. B.
Sarklssiaa. I.
Paalns, B.e.
1975
Clinical Pharmacology
aad Therapeaties
18 (3): 3 50-355


rarst. D.E.
Tozer, T.I.
Relmon, K.L.
1979
Clinical Pharmacology
«md Therapeaties
26(3):380-389







                                                                                                                                                                                         U)
                                                                                                                                                                                         -J
-------
(3-36-5
L7-B5-UJ
10 138.12. It
TISSOB
5021
Salira
5022
Urine
5023
Or ioe
502*
Drine
5025
Brine

157-159 C. BP al
"EHOSTOB «o55F
Ingestioa
Ingestion
Ingestion
Ingestion
Ingestion

oat 211 C at 20 •• I
	 1I1LITIC11
HETBO*

Color iietry
Coloriaetry
coloclsetcy

_ 	
tg
BUSBIB
or cases
12
2
-
-
20
9
a) C
b) 6

(com
~ Hies
O.M6-3.58 sg/100 nl
5«0.7-603.2 ag
1.28-1.86 sgAg/ac
92.4-105-8* of dose
_— -^— ^— 	 • 	 ~
a) 87.0-103.9X
b) 56.0-94.1*

»OBD>
BBlt
1.67* or - 1-03
mg/100 il
581.95 sg
1.51 ag/kg/br
96.83* of dose
a) 95 » or - «.«
b) 77.2 * or - 13.0*



Iia«-a»eraged steady state levels.
nsnal dose 8C sq/kg/day
7-17 yr olds with rheaaatoid
arthritis.
BIOOBTSBBOB;'cHItBB««S »*""!!??)
MIBBITIS: BISZiSBS; COHPlBlTItB
!T»HI1TM!IS: ItlHOIS; WaSOMSWT
BZTHO9S
ticretia* in 2»-hr orlaes. after 300
•g buffered aspirin. Talues
deternlaed by ne» aethod coapare to
>6«.0-a53.9 ag. deterained by
often-ased colorinetric aethod.
aealtliy 22 and 24 yr olis.
HBTI-TWlfcNRlTOTTT ACSBTS
*«-ret:ion of total salicylic acid
afSr 5 da?s on 50 .gAl/«»f battered
asririn in 5 doses. Boderately
correlated »ith »eraa le»els, r-0.50.
Bhenaatoid arthritis patients, ages
20-<« yr.
BMGS: BBW!I»TOI» aBTBBITIS: BIOOD
sci>Qfl; ?Bl*r.; ADOLTS; DISBASSS;
imBOttSB: BfTlBOlITSS
Daily ariae reco»ery. neans alter
1.0. 1.8. 2.1, 2.7. 3.0. and ».0
sg/kg/hr at steady state.
BHlthr 2^-«0 yr olis, on no
abdication >2 -k and «o salicylates
tsosst m-i-nriasHiTOH »<•«*;;:
naiGEStcs: EIOOD w**";,""?115-
m*f: cospaMTirt entMTiois;
BITIB01ISB: aBDXTS
	 	 — 	 	 	 — 	 	 *
,1 Total oatsat after 60 ml dose
b{ Total oatrnt after 60 si erery 6
br for fiTe doses
6.77 aq salicyclic acid/al
Bealthy 28-36 Tr olds, «t 50-82 tg
IIUITS: im««: BIOOB Piassa: ososs:
»1«16ISTCS

~ 	 BZmEBCE

leyy, G.
Procknal. J.*-
Olafs, B.
pachaan, !••••
1980
Clinical Pharaacology
and Therapeutics
27 (5) -.6 19-627
— 	 —
chioa, >.l.
oayenelakve, I.
197»
joarnal of
Pharnaceatical Sciences
63(»):630-632
Gupta, I.
Sarkissia*. !-
Paulas, H.B.
1975
Clinical Pharaacology
and Therapeutics
18(3)t350-355
Tnrst, D.I.
Toier. T.».
Kelson. K.L.
1979
Clinical pharaacology
and Therapeatics
26(31:390-389
reldaan. S.
Chen, S.-l.
Pickering, l-K-
cleary. '-G.
Bricsson. C.P.
Boise. B.
19S1
Clinical Pharaacology
and Therapeatics
29(6)5788-792





CO
oo



-------
Salicylic acid. *-aaiao-  (« ci)
Erazoic acid. «-anltto-2-avdroxv- (9 Cl)
€_"*4i^6
C7-B7-1-03
81 153.13. IP 150-151 C
IISSQB

5026
Blood,
plaaia







5027
Uxine






Ingestios







Ingest ion





BPTB08














•OB BIB
OF CUES
12






-
12





B11GE
a) »-»9.98 ug/al
b) 155.M-* ug/il
c) 121.09-5 ng/sl
d) 139.51-6 ag/«l






-
a) lot given
b) lot given
c) lot given
d) Rot given





1111
a) lot applicable
1) Rot applicable
c) Rot applicable
d) Rot applicable







a) 77.2* of dose (3.1
9)
b) 92.8% of dose (3.7
q)
c) 98.55 of dose (3.9
g)
d) 98.21 of dose (3.9
g)





SEIIMI nrosBiTioi
a) 0.25 and 3.5* hr after
aaiaosalicylic acid. 21 ag/al at S
hi. b) 0.83 and 6 hr after la
aninosalicylate. 57 «g/al at 0.25 hr
cj 1. 10 and 6 hr after K
aalaosalicylate. 32 aq/nl at 0.25 hr
3) 1.02 and £ hr after Ca
aninosalicylate. 30 «g/»l at 0.25 hr
Corrected to 70 leg vt and * g
free-acid-eqaivaleat dose.
lealthy volunteers, no drags or
alcohol for 3 «k, fasted overnight
before and S hr after dose.
D*nBS{ CO-P1B1TIT! mint-IMS; BLOOD
EUSHl; UBTM
a) *BlnosalicyUc acid
b) la aninosalieylate
c) K-asinosalicylate
d) Ca-aiinosalieylate
2* hr cnsalative excretions after * g
doses 1» forns In a)-«). 52.3-56.7*
of dote excreted In aeetylated £or«.
Healthy volunteers, no drags or
alcohol for 3 «*. fasted overnight
cefore and 5 hr after dose.
WOSS; C08P1SIHVE STMnwiORS: BlOOfl


tEFEBElCE
Ran, S.a.
Pentlkainen, P.J.
azarnoff. D.I.
197*
Journal of
Pharnacvntical Sciences
63(5):709-711






Van, S.3.
Peatikainen, P.J.
azarnoff, a.i.
Journal of
Pharuceatical Sciences




                                                                                                                                                                                        CO
                                                                                                                                                                                        VO
Salicylic acid. 5-( (p-(2-pTriaTlsulfaaoTl) pheayl) azo>- (SCI)
155^5^1**    2-n7a«*I-5-({«-((2-PjridiiijlasinoJsnlfonTl)phenjlJa»o)-  (9 Cl)
cie-m«-i«-os-s
BI 398.39, BP 2*0-2*5 C (decoap)
1ISSO!

5028
lenlotic
fluid







JIPOSOSI BODTB

Ingest ion







IHalTTICJt
RCTBOD
- -








BTIBBI8
or CASES
5







BUGS -'

a) lot given
b) lot given
c) tot given
d) lot given
e) lot given






-------
^sa^^                "
il 398.39: « "0-2« C taecosp) (COITMOM) 	 	 	
| II3SOK
5029
Blool,
fetal







5030
Blood.
sena







5031
lilk








"'mosrai BOTJM '
Xnqestion







Xngestios







Xngestion








-
IHLTTICIL


























or C»SBS
5







5







3








-
	 ~ IHeT"
b) lot gi*an
c) wet given
4) Sot given
e) <0.5 ng/sl







a| lot given
b) lot gives
c) »ot given
8) lot given
e) <0.5 ng/sl







a) Wot given
b) tot given
c) Cot given
a} »ot given








BEftl
a) a. 2 * or - 3.0
b) 11.0 * or - ».0
c) «.9 » or - 1.8
4) 0.6 * or - O.S
ag/sl
e) lot applicable






a) 7.3 » or - «.0
b) 10.6 « or - «•*
o) 3.T » or - 2.»
ag/sl . ,
1) 0.5 * or - 0.3
e) Hot applicable






a) 2.7 » or - 1.8
ag/sl
b) 10.3 » or - 1.6
c) l.» » or - 0.7
Bg/m









_ 	 — 	 	 	 	 • 	
a) Salphasalaxine
b) Total salthapyriaiB*
e| icetylatea snlphaprriaise
3) acetylatea svlphapTriaine
glocaroniae
«1 Total S-aniaosalicrlic acia
Reasarea at aeliverr- »ose. 0.5 g.
pwerperiav. Blooa froa OBbilical
cocas.
Salients with nlceratlve colitis who
tscac* preonaBt while oa therapy.
HHIOTTC rtniD: BIOOB SBEOH:
eistsoimisTiMi STSTBBI »J"» _.
giBXlTC*! COBBS »S96 IHSS1M8 BB06S;
iRlBOLIS": BRIB01OTS: MBCntCt;
I1CMTIOW
a) salphasalazin*
b) Total salphaprriaine
e) ac*trlatea sslphaprriaine
a) acetvlateJ s«lphapTriaine
2)U»t™"-ani«o»UcTUc acia
•easirea at aelirerT. Oose. 0.5 g.
•i/aav anriag preanancr ana
EierperitiB.
Fatleats with olcerative colitis Bho
bacaae pregnant aorinq therarr.
HSIOTIC FIOID: BIOOB SEBBSs
SISTFOIWtfSIIMt STSKB: HXU:
nazxiicii coFD: DSBS iBBHaK; DBWS;
llama*'' "ErlBOlIT1!Si P"CT*
a) SBlphasalaiine
b) Total salphapTriaUe
et ieetflatea s«lphapTrtai»«
a) acetrlatea snlphaprriaiM
C.5 i »«/aar aaring pregnancy »•*
paerperias.
patients »lth olceratit* colitis who
heeane pregnant while on therapy.
UIIOTIC ?l«Ds BWOO SZ80II:
sSrSrs.s'.sniWS^Dio.i,
aiTiBoixsii! BR»BOIIT*S: PBSGWUCT:
t»CT»TIO«
BZTVBBld

Troelove, S.C.
British Beflical Joornal
2{620«):1S53







nan, I.X.I.
Troelove, S.C.
1979
British Beaical Journal
2(«20»):1551







Khaa. l.I.A.
Trnelove. S.C.
1979
British Bedical Journal
2(620»):15S3








	 -_ 	 ""'"
-------
frarteine  (8 CI)
7.1«-aetkaBO-2I.CI-aipyrido(1.2-a:t'.2<-e) (t.S)diazocice. lodecahydro-,  (7S-(7alpha,7aalpha.14alpha. 14abeta))-  (9 CI)
90-39-1
C15-826-12
Bf 23*.37. IP 173 C at 8 an Bg
US-HE
5033
Brine










mason BOOTS
-~«"










AI1LTTIC1L
HSIBOD
GC










BOSSES
or CASES
1










BAM:
a) lot applicable
b) lot applicable










BSAB
__^____________— __^-^-_
a) 85% of dose (170
aa)
b) < « of dose (< 2
aq)









GtllSIL IIFOBBATIOI
Is sparteiae
b) As 2- and 5- denydrosparteiBe
0-2* br emulative excretion after
200 Bq as salfate

70 kq, vaite sale pbenotyped as "poor
setabolizer" according to capacity to
t-hydroxylate aebriso-aine and
sparteine.
C?OS3; IB-lBCLIsa; BTriBOlIIES;
01IK; COSPltltlVB ETllaKIOIS:
SID1TITK; BTMOtlCS! AMIPICMICS;
AHIETPEBTEISXTE IGMfS;
BEFEBEICB
Inaba, 1.
Often, S.T.
Fa Ion, i.
1980
Clinical Pharmacology
aad Therapeatics
27 (4) : 5*7-549






 S»lfa»ila»ia«, H1)-(3.«-di«ethTl-5-isoiaiolTl)-  J8 CI)
 z«Bzm«sulfcuiid«, B-a.iBo-1-(3,»-di»thrl-Vlso«axolTl) -  19 CI)
 127-89-5
 C11-H13-13-03-S
 II 267.30. IP 19* C (also reported 195-198 C. 192-195 C)
iissas
5033
a ilk


Birosm: aom
Tl^eation


llainiCAl
HRBOB



BUN BBS
OF CASES
6


11*88
-
a) lot gives
b) lot given
c) lot given
d) Hot given


Mil
a) 18 + or - 8.4 >g
b) 0.45 » or - 0.21%
c) 22.8 + or - 11.51!
d) 77.1 t or - 11.5X


GBI1SU IIFOilUTItm
i) Total salfisoxazole
b) t of laternal dose
c) * of total svlfisoxazole recovered
as snlfisoxazole
3) * at total snlfisoiazole recovered
as >*-acetvl salfisoxazole
tos« 1.0 q every 6 hr for 2* br. 48
III collection period
Caucasians, ages 19-27 yr
EOlKHHfllD'S; BI01CCD1DIATXOI;
HCMtlOl; KT1BOUTK; KAISAS;
IBUUS; ^IH; DKOSS
.
5IFEHEHCE
Kauffsaa. B.E.
O'Brien. C.
Gilford. P.
1980
Pediatrics
97 (5): 839-841


  Snlfaailaiide. ltt)-(4.6-ai»ethyl-2-PTri«iaiBrl)-  (8 CI)
  Bea«nes«lfooaai4e, 4-a»ino-I-(«,«-Si«thTl-2-PTri»iaiiiyl)-  (9 CI)
178-1T9 C,  198-199 C. 205-207 C)
  C12-B14-14-02-S
  Si 718.32. BS 17* C  (also reported:
| TISSUE 1
1 1
1 1
503*
Blood.
plassa

iiposms BOUTS i
Ingest ion

»»nmcAi
!!Z?SOI


BOBBER
cr CASES
5

BUG:
a) 30.8*60.4 qg/»l
b) 73.3-122.5 ug/sl
(IEXT
Bill
a> 41.2fi 4 or - 11.53
»q/»l
b) 103.84 » or -
11.58 ag/al
._ . ..
PACE)
GE«iB*L iironnATioi
a) Peaks, 1-3 lir after 10 igYkq. b)
leaks. 1-6.6 hr after 40 aq/kq.
t«altby 2?-3« rt olds. »t 7»-96 kg,
fasted 12 hr before to 2 kr after
dose.
01IIE; BLOOD PLKSH; DB7BS;
miAaoiisa: IETABOIITSS

BEFESBItCE
da Soaicb. ?.
lalka, D.
Slaughter. E.
Elvin. A.T.
HcLeaa. A.J.
1979
clinical Pharaacology
and Therapeutics
25(2):172-193

-------
  Snlfanilasidc, H<1)-{*.6-diaethyl-2-pyrini
-------
Silranilanidc,  «<1|-
C10-B11-I3-03-S
Bl 253.31. HP 187 C
                                                      -  (9


5039
Blood,
plasna
50*0
Blood,
eer»
50*1
Far fluid



Ingestlon
	 	 ____.
	 __
Ingestion
	 	


BETHOD
TLC
coloriietry
HWC
BPIC


OF C1SBS
1
.
7
7


BUGS
--
26.33-1*.* ng/nl
Hot given
,
2.81-25.7 Og/ll


BE*1
Mot given
»».6 « or - 22 ng/sl
8.21 * or - 7.0 ug/nl


SE1IUL IIFOX8HIOI
0.5 and 25 hr after 160 nq
ttlMtnoprl* and 800 ng
smtaiettoxazole.
CBHGS; 11TIBIOIICS; BLOOD PL1SH1-
BMSBSEHIT HETBOSS
— 	 — 	 — 	 __ 	 ._
, T^ olds vith chronic serovs
otltis sedla.
BIOOB SMDB; F»B THUD* **'
" ' ' ~ 	 	
'
2tlti' Ol4s *it!l CBronic s««'os
— _rt » iHrECTIOHj CBUDBZX j


BEFBBBICE
Sigel. C.H.
Grace. S.s.
vienol, C.».
Hltchings. G.B.
197*
Jonrnal of
Phariaceatical Sciences
63 (8): 120 2-1205
Kliiek, J.J.
Bates, T.B.
nightingale, C.
letnann. ».B.
zieniak, J.I.
Qnintiliani, P.
1980
Jonrnal of Pediatrics
96 («) :1087-10B9
Klinek, J.J.
Bates, T.B.
Hlgntlngale. C.
lehninn. «.B.
zienniak, J.I.
fluintillani, P.
1980
Joarnal of Pediatrics
96 (6): 1087-1089

£il«»silaiid€. I(1)-2-pTridrl- IB CI|
                    a-aniBO-B-2-pyridinTl-  (9 CI)
                                                                                                                                                                                          OJ
C11-B11-I3-02-S
El 2*9.29. HP 191-193 C

50*2
Blood,
sera*

	 	



BX?BOD



IDBBEB
OF CiSSS
15


~~ B1IGE
0.8—28.6 vg/el


BUI
18.17 ng/sl



1
s
e
at
a<
1
D
1]
r«
CI
CI
                                                                                                                              SHIBJL IIF01MTIOI
                                                                                                                      and 9 hr after 22-68 ng/*a
                                                                                                                    snlfasalaziiic in doses divided
                                                                                                                       jllY 2t or «/lay.  Inclodes
                                                                                                                       trlat«a and glacuronidized
                                                                                                                    netabalites.  10 rapH acet7lators,
                                                                                                                    12 raT»id hydroiylators.

                                                                                                                           yr olds, «lth Crohn disease or
                                                                                                                    olcerative colitis.

                                                                                                                    ill b«t one in coaplete clinical
                                                                                                                    r»ls«ion after >1 vk Uerapy.

                                                                                                                         ;  onus IBEBIW; umBoiHEss
                                                                                                                    CETIDSEl;  ?LCOD SntBB; BrUSOLISH
                                                                                                                                                                   BEFE5EICE
Goldstein, p.p.
llpers, D.B.
Keating, J.p.
1979
Joatnal of Pediatrics
95«):638-6*0
-------
                  .. 3.7-di.Tdro-3.7-dl.eth,l- f*

t3-67-0

Si~ieo!l7?2B* 357 C. BP 290 C (Bubli.es)

1ISSOI
50*3
filooJ,
Flaasa
50M
Rilk
504 S
SlllTI


IIPOSOBE aOBTE
Ingest ion
Ingest ion
Ingestion


Iliimcit
HETHOD
BPIC
BPLC
BPLC


»OHBEB
OT CiSIS
6
•
<
6


| B»GB
».5-7.8 sg/1
3.7-7.5 ag/1
a. 5-8. 2 ng/1



5.7 »g/l
5.3 «g/l
5.7 sg/1

                                                                                                                             GB1IS1L HFOTBatltH
                                                                                                                    Hter  113  
-------
ineopbviiine  (a cq
1F-Puriae-2,S-dioiM, 3.7-aibvdro-1.3-aisethjl- (9

C7-B8-B4-02
El 180.17, BE 270-27* C
                                                                                     (COBTIBHED)

5047
Blooa.
plasaa






5048
Blood,
plasaa







5049
Blooa.
plasaa








5050
Blool.
plasaa










Ingestion






IngestiOB







Ingestlon








In lection









BETBOO
BPLC






BS1C







GC








BPLC









or cisss
14






4







12








1










a) 9.3-17.1 ng/1
b) 4.3-8.9 ag/1
c) 13.3-51.3 ng/1
4) 7.9-20.4 ag/1






a) 0-135 ng/nl
b) 45-110 ng/nl
ct 60-165 ng/Bl
d| 70-195 ng/al
e) 95-185 nf/nl
g) 125-190 ng/al
f) 145-195 ng/Bl
h) 45-160






a) 9.7-4.9 ng/sl
b) 21.1-11.6 ng/al








a) 8.25-0.6 ng/al
b) 17.5-0.85 ng/Bl
ct 12.0-0.50 ng/al
dl 17-0.7 ug/nl









BUI
at 12.8 ag/1
b) 6.5 ag/1
ct 25.2 ng/1
at 13.2 ng/1






at 49 » or - 30 ng/nl
b) 79 * or - 15 ag/al
c) 106 » or - 22
nq/nl
d) 118 * or - 27
ng/Bl
e| 133 * or - 19
nq/al
ft 16314 ng/nl
g| 173 » or - 11
ng/al
hi 99 » or - 6 ng/al
(S.E.I


a| «ot giv«a
b| Bot given








at lot given
b) Bot given
c) Bot given
at Bot given









SlIMll XBrOBSmOB
at Peaks after 5.6 *g/kg. total body
vt basis
It Peaks after 5«6 ng/kg. ioeal body
•t basis
c| Stealy states, 0.9 ag/kg/hr. total
tody «t basis
at steal? states. 0.9 ng/kg/hc. Heal
Ccee as aainophvlliae.
Cbese 23-5H yr olds
tBtJSS; BLOOD PLaSHI; TBIOPBtltlBIS:
CCBPIB1TIYE PfltOSTIOIS
~
a| Ifter O.«i hr
I) ifter 1 hr
c| Ifter 1.S hE
at Ifter 2 hr
e| Ifter 3 hr
fl Ifter 5 hr
9) Ifter 7.5 hr
h| Ifter 24 hr
relieving 300 ng aose of caffeine.

volunteers. Canada

C1BIDI; ID01TS: BIOOD PIISB1;
mBETTCS: DEOGS; ROSCLB BELITJUTS;
CCB.PM1TIVI ETILOITIOBS: BCTIBOUTBS
a| Beaas after 225 ng/12 hr
t) Beaas after 450 ag/12 hr
Administered as aalnophvlline,
sustained-release capsale
Healthy 20-33 yr oias, one snoker.
Bo caffeine-containing beverages for
24 hr ana tasted overnight before
etndy.
ion dose effects: nild headaches.
anxiety, and palpitations. High aose
effects: naisea, voaltiog, insoania.
aaiiety, headache. Syaptoas nore
likely at plasna levels of >1? o^/al.
tlHTBD KIBG9CB: IDOLTS; BIOOD Pl»S»I-
MOGS
a| Control trial (no antibiotic)
b| Orng * tetracycline
c) tmg » etnhronycin
4) Drug * cephalexln
*> nln ana 2» hr post-infusion.
latibioUcs given as loading dose of
•!00 no DIBS 250 nq/6 hr, oral. « nin
IV of 5 nq/kq aninopliTliine after 4th
antibiotic dese.
flealthy 21 tc 33 vr oias. no
lanthine-eontalnlnq foods t beverages
t store and after dose.
Tachycardia and slid treanloasness.
tSOGS; 1BTISIOTICS: TBlOPHTtLIHSS:
E1COD PllSBD; 1 DOITS
(KIT P»SE) 	
8IWBEBC3
Gal. P.
Jnsko, B.J.
Tnrchak. i.g.
Franklin. B.I.
1978
Clinical Phamacology
and Therapeutics
23 (4) : 438-«44



Sved, S.
Bossle, B.D.
BcGilveray, i.j.
1976
Pesearcb Conaaoications
in Chenlcal Pathology
and Pharaacology
13 (2t: 1*5-192






Trenbath. ?.P.
Boobis. S.».
1979
Clinical Pharmacology
and Therapeutics
26(51:654-659







Pfeifer, H.J.
ereenblatt, D.J.
Frie4aan. p.
1979
Clinical Pharaacology
and Therapeutics
26 (It : 36-40









                                                                                                                                                                                         Ui
-------
theophylline (9 CI)
1B-Puri.n«-2,6-dione
5E-S5-9
C7-BS-I4-O2
II 180.11, »B 270-274 C
3.7-dihydro-l,3-ainethyl-  (9
                                                                                      (CORIROED)
	 T m' 	
TISSUE
5051
Blood.
plasma









5052
Blood,
tlasaa












Hood,
plasna



S05»
Blood,
serai






KXPOSOKS SOOTI
Ingest ion









Ingest ion











-




Infection






nunicii
BETHOC



























BPLC






HOMES
OF C1SES
18









1























~" JMGB
a) 0-14.9 «g/»l
b) 0-12.0 ug/nl
c) 1.5-14.3 «g/nl
1) 1.5-14.0 «g/nl
«) 7.7-11.6 ng/nl
f) 6.5-11-9 ug/nl









a) lot applicable
b) 120-31 mg/1
















a) 0-24.0 ng/1
b) 3.9-17.0 ug/nl
c) 8.1-35.2 ag/ml






a) 6.3 * or - 4.7
uq/ml
b) 6. 3 + or - «.S
ag/»l
c) 10.2 * or - ».*
ag/ml
1) 9.2 * or - «.3
ag/»l
e) 9.S » or - 1.1
na/al
f) d.8 + or - 1.9
ag/il





a) 1*6 ig/1
b) Rot given
















a) 6.7 ag/al
b) 8. 3 ag/il
c) 15.2 ug/«l






a) Tablet, 0.5 hr
t) Elixir, 0.5 hr
e) Tablet, 1 hr
6} Eliiir, 1 hr
e) Tablet, 0 hr
f) Eliiir, » hr
I lies after 375 >g dose in fora
stated
patients vith chronic obstrgctiTe
long disease, lean age 59.4 re.
IDEtralla
Significant tronchodilation
JDStSltli; &EOITS; DISEJSES; BLOOD
PtaSHl: BUTBETICS: DBOGS; nSCS.1
RIUT11TS; CCUPiSlTITE BT»LB»TIOKS :
E!S«B»TOFI ETSTEI
a) 16 hr after 1.S75 g as
sustained-release tablet
t) 0 and 170 ain of charcoal
heioperfnsion
15 yr old, 43 kg overdose patient
iTpotension and tachycardia after 10
ir, then cardiorespiratory arrest.
icldosls, hypokaleaia, cardiac
arrhTthaias, tachycardia after
resascitation. aspiration pnennonia
and acute renal failure after
teaoperfnsio.
IEWJPBTLL1HES; L»»IGE; HTJCTE»SIOI;
BHLT1 1»?»StS: DSOG 1BOSEJ OHTED
KI*SBO'!: 91CCD PlaSHi; DFOSS
BeTiew
Chronic dose torieity: anoreria,
nausea, voaiting, abdoninal
disconfoct. Serious toaieity
(cerebral seiznres, oardiac
arrtrthliss cr respiratory or cardiac
arr«st) is infrequent.
mm: TBEOPHTLLIIES; DISE.SES
a) Tine 0
t) Change following 6.0 ng/kg IT
aninophylline
e) Peak levels
isthnatie 0.5 to 20.9 yr olds, on
2.7-9.S no/kg oral tbeophylline
lailting, trenors
III YORK: CHIIOSI*: BLOOD SIB01I; DPBG
**niPTl THfOPHTLUMS
	 	 	 	
BEfEBEKCE

Hartnett, B.J.S.
Darlin, G.E.
Grahaa, G.
1974
nedical Joarn&l of
lastralia 1 (14) ;532-53S









Jefferys. D.B.
Baper, S.B.
Helliwell, B.
Berry, St. 3.
Crone, ?.
1980
British Redical Journal
280(6224) :1167









Piafsky, K.!!.
Ogilrie, B.I.
1975
Rev England Jonrnal of
eeflicine
292(23) :1218-1222



canavan, J. V.
Ellerstein, B. S.
Soil IT an. T.D.
1980
Journal of Pediatrics
97(2) :3C1-303




(HIT PUGS)
-------
Iheophylline  (8 ci)
                   ' 3'7-*illTa™-1.3-"»«thyl- f9 en
C7-H8-1»-02
•I 180.17, HP 270-274 C


5055
Blood,
sera*



5056
Blood,
sera*





S057
Blood,
sera*













5058
Blood,
sera*














lagestion












	 	
Ingestion


-
VRHOD
IPLC



CC





Enzyne
Inmnoascay













HPLC



(COITIlUfD)
ttUSBfB
OF CASES




20





21













20



B1VGE
a) not given
b) Sot given



a) 1.7-26.2 ng/1
b) 1.7-26.6 ng/1





a) 0-44 unoles/1
b) 20-65 aaoles/1
c) 27-70 aacles/1













6.7-23.5 aval



Bill
a) 5.92 * or - 2.»
•g/i
b) 2.52 * or - 0.96



a) 9.27 » or - 6.2
•q/1
b) 9.26 * or - 6.2
•
-------
                     3.7-ailTdro-1.3-«i.eth,l- (9 en
•8-55-9
rl 180.17, H
TISSUE
5059
Blood,
sens
5060
Blood,
seraa
50*1
eiooi,
serai
5062
carebrasp
iBal/TSBt
ricslar
flail

P 270-27* C
~ EISOSUBB 80ME
lBlectlo»
lBge*tioD
Injection


	 "~»B_1TTIC1L
KTBOD
HPLC
snc
ac
HPIC

IDS BBS
OF CISBS
4) «
b) 7
14
15
S
	 —
(C01TJ
"~ iiicl
a) 0-12.* BO./B!
b) 0-8.? BO/sl
a) 11.5-0.5 B«/sl
b) 15. 1-0. « «9/»l
3.9-19.5 a«/Bl
4) let giTen
b) lot o,i«n
• IEDI
sir "~
	 . —
a) Mot giTen
b) Hot gi»en
. . ____ 	
a) lot gireft
b) Hot gl»«»
11.0 * or - 5.1 «J/nl
a) 5. 25 « or - 3.5
b) 2.16 » or - 1.06
•1/1
	 	 -GHSB11 nWiiWIOI
a) 0 «B« 20 tin .ftet lOBdiiiq lose of
6.0 •g/fc9 (20 •!» I»I »«a then 0.9
.,/kq/hr for 100 B!B. SteaflT state
of 11 B<|/il at «0-2«0 Bin
b) 0 »»« 20 BiB after loading lose of
t ma/Ya (20 BiB IT) aB< theB
,.I!t«aBCe dose of 0..5 .,/lc,/hr to
»chl«»8 s«rn« letel of 5 n^/Jl-
Stea«T at«»« of 7 •O'"1 •' 3
•ealthT 22-33 yr olds, fasted 8-12 hr
before, aad duriB? BtqlT-
080SS; TBZOPHmiKS: B100D SfSOH:
HEOHS
a) Basse of B«aBS, I-2*™* 2* hr
after 300 Bg as aonalcotolic
BBiBOpirUl"* "olrtioj. ^I;lt}»1
.easoreaent, 1.8 «
-------
                                       Mtkn- C9
;«-S5-9
C7-B8-M-02
Ct 180.17. « 270-27* C
                                                                                     (COITI19BO)

USSM
50*3
9riB*















nnsaHS BORE
lBl«CtiOB















AlLLYTlClt
RET BOD
BaAlOeMtCT
cc















•BflBBB
or C»SBS
3















I1BGE
a) a.7-10.7*
b) 5.3-11. 2*
c) 16.0-18.M
d) 19.0-23.2*
e) 26.1-33.2?
f) 33.9-38.3*
q) 13.1-25.3*
k) 10.6 20.5?














1 	 • 	
a) 7.3* 1 a) TkeopkylllBe. asaal diet
b) 9.0* 1 b) TkeopkvlliM. BethTl*aatkine-rEe«
2 2UT* 1 c| 3-SetkTliaatkiae {Betabolite) ,
e) 29. *« 1 !•««! diet
fi 35.9* I d) 3-»et»Tl«atiia« (Betabolite).
a) 18.3* 1 •«thTl»aithi««-fr«e diet
k) 17.7* 1 e) 1.3-DiBetkYlacic acid
1 (setabolUe) . eseal diet
1 f| 1.3-BlBetkTluic acid
1 (aetabolitel, B«tkTl««»tkiBe-fEee
1 diet
1 B»al diet
1 k) 1-HethTl»tie acid (Betabolite) ,
1 a
-------
 tl,lo»«thene-2-s«lfosanide,  I.I-
-------
 *«boc«rari»e
C37-BM-I2-CC
•1 609.80
                 "I  (T.ij

                 Tf'12f-ai»*««'T-«.«'-«i««t*«r-2.2.,2.-trl-tbIl-  19 CD
TISSUE

5967
Blood.
Flassa

BIPOSOBB BOOTI

Injection
— _____ 	


BETBOD
— 	
in


BOSSES
OF CASKS
10


B1B6B
•) 5-6 ag/ml
b) 0.45-0.95 aa/Bl
e) «-«.« «g,sl
4) 0.5-1.5 ag/Bl


Bill
a) lot given
b) lot glTen
c) Mot given
d) Rot given


" SSBIBII isTomnoi 	 ~
•1 tornals. 3 lit
t) local*. 120 Bin
c) Imal f« Hares. 3 sin
Jl Benal failares. 120 tin
J«?f ^J'J* aos" of °'5 "*^' "•
I8tl»t«9 fro« gcapki. Data alao
9iT«» foe 0.3 iq/tg dose.
!.J*?*1:.'l*Ctllr* "C^'r patt««ts
«2.? J'lH**** wltt <*w>»ie «»«-«ta^
r««al fallira, prior to !ciaBeT
traa*pu>t.
IciporatT patalyaU correlated »ith
flr«9 I*T«I. Half laitnl effect at
0.3i . ,t - 0.03 nq/il.
jsnss; one Tnnm: gnscis
!S«lnS' BIOOD 1»*»»l KIBKI
CISMSIS; COWIBITIT8 ET»lniTIO»S


BIFEBHCE
Sketaer. l.B.
Stanskl. D.B.
Toieh. s.
Hiller. S.D.
Haa, J.
1979
Clinical Phariacologr
and Tkerapeatics
25(31:358-371

      . 5-flioro- (g ci|
C«-B3-f-12
•» 130.0». HP 282-283 c (iecomp)
IISSV8
S068
Hood.
Flasu
--
S069
Blood.
plasu

BXVOSOBS IOOTC
IP dialyais
-
Injection
Invest ion

1IHTTICII
RTBOD
BPIC
— — — — — ^_—
BPLC

•OEBSI
OF CiSIS
1
11

B1ICB
3. 2110(2-5) -1110(8-71
•olea/1
a] 6.4-29.5 og/nl
b) 3.2-17.8 ug/nl
c) lot detectable-0. 1
ug/al
d) 1.2-11.3 «g/nl
e) 2.9-12.2 ng/al
f) 0.1-0.9 uq/nl
(IIR
iili
lot applicable
a) 13.4 » or - 9.«
>q/nl
b| 7. a * or - 6.1
nq/al
c» 0 «g/il
11 5.6 * or - ».9
«q/«l
«» 7. a 4 or - 3.9
nq/Bl
f) 0.3 + or - 0.3
«0/Bl
P1GE)
	 	
S'lIJlL nrCBMTIOI
1? "J,180 •i* *«•' start of » hr.
" «J»j7Sl« contalnln, * nnoles dri,.
Initial eeaiuenent. 6X10 (E-6)
?S«"!/Jl ''•titoneal lenls about
ta'k »ia»«- Batinated froi
Jatient «ith MliqaaBt disease in
IntraaMoniaal space.
Eo«e-ltBitiB9 tojiclty:
Ii;i«?;?rr""l8B' """^Ttopenia.
»cositis. laasea, rash, alopecia.
CoiBlete or partial mission IB 2
•ith OTarian caacer.
MOM! CHHOT1EB4PT: IHTIMB; BtOOD
PltS-ll; PniTOHMl FIOIBj IECPLISBS
a) 5 Bin after 250 ag. IT
t» 10 Bin after 250 ag. IT
e) «0 Bin after 250 aql IT
! « "J" after 50° •>• oral
e) 20 Bin after 500 aq. oral
f) 60 ala after 500 aq. oral.
CarciBoaa r«tl«nts, after
•attectoaies, Enoland.
01ME9 RKVCR; I9BWSJ ClSCHOtlS;
HCOD VLISIl; DBOGS; CO!)P»B»TITt
If»ln»TIOIIS: CHBOTBIB1PI


Sper«r. J.I.
Collins, J.».
Deflriek, B.I.
Brennaa, B.T.
Baeltpitt, i.B.
Lander. R.
BeTita, T.T.. Jr.
"Ters, c.E.
19SO
Cancer Research
»0t 567-572
Phillips. T.I.
Powell. 1.
Griere. F.J.
Belling. P.S.
1980
Journal of
Pkaraaeeotlcal Sciences
C9(12|:U28-ia3i

-------
 Oracll, 5-flooro- (8 CIJ  t»lt)
 S.a(1B,3H)-Pvrimidi*edione. 5-fl«oro-  (9 CIJ

 51-21-8
 Ca-IJ-?-B2
 Bt 130.08, IP 282-283 C  (decoapl
                                                                                       (C01TIIOED)

1ISSBB
5070
peritonea
1 fluid


BIPOSOM BOOT!

-

lllLTTIClL
RTHCD
BP1C


BOB BBS
or cisss
10


811GB
VOt $iYiM


1B1I
17.6 » or - 7.9* of
instilled
concentration



a br after 21 dialysate containing 5
aB-i BK drag. Bonoexponentlal
decline
Patients «lth aallgaant disease ia
intzaabdoslnal space.
rose-Halting toxicity:
•yelosappression, tbroabocytopeaia,
ancositis. laasea. rash, alopecia.
cosplete or partial reslssioa la 2
i 1th ovarian cancer.
91D6S; CHIBOTBBH1PT; S1BTHBB; BLOOD
SUSHI-. PEBITOHBAL EUJ1D; BECPIASBS

EirEBEBctt
	 	
Speyer, J.L.
Collins. J.B.
Dedrlck. t.L.
Brennan, 8. P.
Eackpitt. I.E.
Lender. B.
DeYita, ».t.. Jr.
Hyers. C.E.
1980
Cancer Besearch
•0:5*7-572

                                                       CI,
51-52-5
C7-B10-B2-0-S
BI 170.25
tISSBB
S071
Blood,
seraa
5072
Bilk

BZPOSVM SOOTS
Ingestion
Ingestion

numcit
SETBOD
Badioa«try
Sadioaetry

or CISES
1
1
~ 	

0.0018-0. OC02*
radioactive dose/al
0.000 3-O.OOOW
radioactive dose/al

Bot given
(at given

C and 2* hr after 100 sg
Fropyltkionracil containing 100 nCi
labelled drag
m*: seras aoa-protela boand S
activity ratio » 0.55.
lactating aether
CBDCS; BSOS THIBIM! BLOOB S1BUK:
BIIK; LICTlTIOBi SCOTIMD
6 and 2» kr after 100 ag
ciopylthioacacil containing 100 ncl
latellel drag
Bilk: serna non-protein bound s
activity ratio - 0.55.
tactatiag sother
D51JGS; BB06 TIBS1M; BLOOD S1EBS;
•IK! HCT1IIOB; SCOtl»IB
	 	 	 	 	
BZrEREKtt

lov. L.C.I.
Lang, 3.
Alexander. ".0.
1979
Lancet 2(8150) :1011
Ion, I.e. K.
Lang, J-
llexander, 1.0.
1979
Lancet 2(8150) : 10 11

.£>
ro
Orea. 1-|(p-chloropke«yl|snlfonTl»-3-propyl-  (8 CD
EenMnes.lfoaaaide. a-ckloro-«-{fpropTla»ino) carbonyl)-  |9 CI)

9«-20-2

CI 276.75, •? 127-129 C (also reported 125-127 C|

IISSO!
5073
Blood,
aeraa


SIFOSVIS B01TTZ
laqestian


1I1LTTIC11
SET BOD
OC


ROBBER
or CASSS
97



34-667 ttBOl/1

. . _

tot giT«o



Cese* of 125-500 ng
33-90 n old patients «itb
•atartty-oaaet diabetes
tJOGS; DMBWSS: BLOOD SIBU8; SUDSK

BirEBEICS

Becgaan, 0.
Cbristensen, I.
Jansson, B.
nihola, B.-B.
ostaan, J.
1990
European Journal of
Clinical Pharnacology
18: 1«-1*9

-------
 Valeric add. 2-propyl-  n CZI
          'cla'          '
CC-B16-02
If 1M.21,  IP 120-121 c ,t  t« ..  fg.  ,2..l3o e at 20 ..  B,
nssm

son
Blood.
plama








ilood.
plasea





Blood,
aeraa






lagestloa








lagestloa





tagestloa





1I1LTTICU.
ntBos
«e







— 	 	 _
DC





ec





ntstft
or cists
76








6





6





Hisi
a) lot givea
b) Mot glvea
c) lot girea
41 Bot girea
•1 tot gir«a
f) lot givea








31.8-S2 ag/al





a) Bot glTea
b) Bot glvea





Mil
a) 65.1 + or - 20.3
b» 91.7 * or - 35.2
e) 5*. 6 » or - 26.5
4) 33.8 » or - 28.2
ag/al
e) 63.1 » or - 51.9
ag/al
f) "3.8 « or - 2«.e
ag/al





not gi»«a





aj 3*.* « or - 5.1
b) 27.1 * or - ».«




veittii nrotuTioi 	 	
	 	 	
a) ifter 785 * or - 259 mg/day.
atlzares eettrolled
h) ifter 785 + or - 259 ag/day.
aeizares aot controlled
c» after 1002 * or - « 15 ag/day »
Fheaobarbltal. Hlztna coatrolled
u) izter 1002 * or - 415 *a/A«v *
P.«»ob.rblt.l. ^1,.«. .,? T
controlled
el tfter 12«8 » or - S18 ag/day »
coBtroll*d e*ft*Bl**ata. aeizairas
1} ifter 1268 * or - SIS ag/day »
Ifileptlc chlldrea. Federal Mvablle
of Seraaay «-P«DI.IC
laereaaad appetite aad might gala.
jaatcoiateatiaal diatarbaacea.
tiaaaleat hair loss, fatlgae
CH1E1T; CB11DRKM; CBBTB1L BnyoOS
ITlLVaYIOlS
2."day2 b%S*It218 " 2V2*T f°r
at 10 hr. Tatlaated froa graph.
_ ^
ef aay drag. ** °la C*"e*sl"ul' fc««
trass ; BROS nrnicrioi; IBTJMS;
liSSE."*8"1* SSBWItSSj ByfBOTICS:
imcarynsiBTs: WTWOIISB
a) Bay «
b) Day 22
il^lll"f a*«»4y-atate levela ea 250
ag/12 hr oa daya 1-22 aad 200 ag/day
carbaaazaplae days 5-22. Day * V ?J
levels dlffereat. P<0.0005.
* T^ oLfls^ BO othcc dcvos
SBOOS: D»5C UtraiCTlOl:
iittconvoisins: H.OOB SHBB; »ootts


B2FZBBBC1
Klotzff 0.
1980 *"*
lateraatlanal Journal
of Clinical
Pharaacology. Therapy
aad Toxicology
I8(l0):«61-ae5







Patel. I.B.
le»y, ».H.
Co tier, I.E.
1980
Clialcal Pharaaeology
aal Therapeatlcs
27(»>:515-521

Bondle, T.I.
l*»y, I.B.
Cutler. e.E.
19T»
Clialcal Pharaacology
aad Therapeatlcs
2«(5|s« 29-63*













JS










-------
».i«ic .en. 2-propyi-.       .
Pentanoic acid. 2-propyl-, sodlm
Kf 9-66-5
C8-B16-02.*a
II 1*7.23

1ISSOB
	
50TT
Blood.
plasna



BIPOSU1S toori"
Inoestlon



iBumcu
METHOD
_
ec



•OBBEB
or cuts
10




	 	 	
a) 2»2-«11 oaoles/1
b) «62-11»2 unoles/1
c) 335-842 asoles/1
..


~ BBAI

a) 397 + or - 109
nsoles/1
b) 679 * or - 235
aaoles/1
C) SOS * or - 157
nsoles/1


	 QliUll ISrOBBmOB
	 	 	 • 	
• ) Banqe Of llnimaS
t) Banoe o( sa«is«es
c) Baoqe ol teans
ifter si* s««tbs o« daily nalntenance
doses calculated (fro. single-dose
(«00 a,) data) to yi*!* •""• °J 5"
»oleg/l. «•• to peak after sinale
dose. 1.8 » et - 1.0 hr.
9-67 T* old «pileptics. vt 27-91 kg.
JS08SS D»DO «EB»*f: IHTICOBTCISISTS;
BIOOD nisn: »osn»ui: COBS»«»TITB
IT»LO»TIOBS: DXSUSCS


BEFIBBIICB
	 	 — . 	 	
Schapel. S.J.
Bera*. B.C.
Doeclte, C.J.
O'MillT. '-a-
Bcecer »•»•
Bisckbletk. B.B.C.
SaftSXW, L.».
Stanley. *.«•
1980
European Journal of
Clinical Pharaacologi
17:71-77


                                                                                                                 - (9
5J-I3-9
C27-B38-B2-C

"MSSOE
5078
classa








t 2*3-2*6 C at 0.

ETPOSOBE- B001B
•
Inlectlon







- —

91 SB Bg

HETIOO
Plnoronetry











BOTBZS
or USES
a) 9
b) 6







	



	 BIB6B
a) lot given
b) »ot giv«n












a) 52 * or - 7 ng/nl
b) 95 + or - 16 ng/nl
SB










	 gilEBll IBTOBilHOB
	 . 	 • 	 •
a) Besponder*. dose 0.066 *or- 0.099
t)9/»on-respe.ders. dose 0.189 *or-
Sesnonders kad ventricular rate of <
100/nin after < 5 eg. Boj-responders
kad ventricular rate > 100/iin after
dese of «p te 5 nq.
20-70 yr old patients vitl atrial
fibrillation or atrial natter.
tecraase in ventricular rate.
Transient decrease in systolic blood
treasure In sone.
MD65: B100B PllSSl! HE1BT 01SE1SSS;
IIOCD PBBSSOSI; 1501TS



BEWBEBCE

Doalnie, 3.
eclllister, E.G.
f«o, c.-S.
•eddy. C.P.
Snravicz, B.
1979
Clinical Pharnacology
and Therapeutics
26 f6): 7 10-71*





	 	 	 	

7«8-9«-5

C1I-B17-I
11 151. ZO, 9f
1ISSOE
S079
BlOOi,
plasna
1
\
\
\
\

"BMOS9BB BOKt"
laqestioa


~~ iB»tyticii
RETBOD
ec
i 	 .

BOBBSB
or CISBS
al «
bl »
ej 5
1
.1 	


a) 65-13* ng/»l
b) 275- »67 nq/nl
c) 597-1373 ng/nl
1

	 SB»I~ 	 ~~

a| 103 ng/nl
b) 32* ng/nl
c) 1282 ng/nl
nelians
I
1
.« _.. 	 	

	 GBBEBll IBrOB»»TIOB

a) Dose of 0.39-0.»7 nq/kq/12 hr
bl Dose of 1.29-1.6* ng/*«/12 nr
C) Dose of 2.07-2. «0 ng/1tg/12 »r
levels tkronqliont dose interval at
tteady state
lealtky 19-3€ vr olds, vt 51-79.5 *g.
fasted before and after dose
| B»1<5S: BICOD Pl»S1l? UBIBS; ClBWk!

BirEKBCE

»o*.i, J.T.
Sitar, U.S.
cqilvle. B.I.
1979
Clinical Pharaacologv
and Tbecapentics
26 (6): 7 29-7 36

-------
 1-ldauatanaalne  f§ CD
Tricvcl3<3.3.1.1(J,7))decan-f-aaine  f» CT)
7*8-94-*
C10-I17-I
N 151.2*. B* 160-1*0 C. 180-192 C
                                                                                     ICOITIIIBD)
TISSOB
5080
urine







Birosni soni
Img«stioa








lIUTTXCn
SETSWB
GC








posses
OF C»SBS
») 4
b) 4
cj S






iiiee
«| 0.68-1. 8W of dose
b) 0.85-1.41* of dose
C) 0.11-1.4T* of dose






Mil
a) 1.07 « or - 0.53%
of dose
b) 1.075 » or - 0.2»<
of dose
e) 0.««6 » ot - O.SSt
Of dOSe



CEItBlL IIF08I1TIOI
•) Bose of 0.39-0.47 19/119/12 kc
b) Dose of 1.29-1.64 iqyltq/12 br
c) DOM of 2.07-2.80 *q/koyi2 br
!i««tio> OB dir '5

BMltbT 19-3« rr olds, *t 51-79.5 kg.
f»»t«a b«forc and after dos«
IHD6S; BLOOD PUSH; OKIE: CilUk;
1 COLTS
IERBKIC!
aoki, T.I.
Si tar, D. S.
OqllTie, B.I.
1979
Clinical Pharmacology
aad Tberapentics
2«(6):729-73«


1-ttopaftOM,  1-t4-(a-bTdro*ipb««Tl-l-1-»«tbTl-a-plp«ridTl)-  (8 CI1
1-ftopamOB«,1-|»-(3-brdroxjpb»«Tl>-1-»^bTl-4-plp«riaiBil)-  (9 CI)
•69-19-4
C1S-B21-1-02
11  247.33,  H 156-157 C
ussni i
5081
Blood,
plasnn

I
j
1
1
\
1
1
I
1
1

EXPOS18B BOOTS 1
1
Injection
InqestioB











aliLTttciL
SC/1S




1
1
1
1
1
1
1
I
IDHBSB
or OSES
5
1








1
1
U16E
a) 20.7-49.8 ««/•!
b) 8.97-12.69 ng/al











BBal
a) 35.1 * or - 5.92
ng/nl
b) 10.79 » or - 1.86
nq/nl









1
5MIEJ.L ItTOBBMIOl
a) 0-6 br averaqe levels. 10 mg IT
after recovery from anesthesia, 4
patients
b) 0-8 hr averaqe levels. 10 mg.
crallv. 2 davs post-surgery. 3
patients
Coapatel from area-nnder-tbe-cnrve
data.
Hoee-svrgery patients, ages 20.7-48.0
yi. Heights 55-82 kg.

StlBEI; BIOCE PlaSHl; MU.6ZSICS;
evoes; xtsconcsi SUECBBT

BETEBEBCE
Bondessen, 0.
arner, 5.
anderson. P.
Boreas, i.o.
BartTlg. P.
1930
European Journal of
Pharmacology 17:45-50






   1,2-»ropaaediol, 3-lp-cbloropbe»oxy)-. 1-eacbanate (8 CI)
   1.2-Pcopanediol. 3-<4-cbloipb«no»y|-, 1-carbanate (9 CI)
   886-74-8
   eiO-B12-Cl-»-04
   •1 24S.61, HP 89-91 C
HSSOS
5082
flood,
acrnn

ET.MSOR BOOT! 1
1
Inqestlon

HtllTIClL
RE7HOD
GC

BOS BE!
OF CISSS
4

HUGE
9.29-3.4 ag/nl

BBlI
Rot applicable

GI1IB1L ItrOSH&TIOl
fanqe of Kans 1 and 8 br after last
ef multiple dose regimen (400 mg/6
hr). Initial value, 5.35 aq/«i at 0
t>r.
lor Hi 28-37 yr olds.
tHIGS: ItlSBSEBIIT B1TBODS; ILOOD
snmii: itnLTS: CBLOSI^E oiciinc
ccusoims
BITBBSBCI
Kaiser, D.6.
Sba«, S.R.
1974
Journal of
Pharmaceutical Sciences
*3C7)5 1094-1097

-------
1,t-B«phtkalaaedlone, 2- l3,3-dlchloro-2-rropenTl)-3-kTdroxT-
36»17-1«-0
C13-B8-C12-03
n 283.11

IISSOE
5083
Blood.
plnsna
SOB*
Drine
EIKSBll BOOTE
Injection
Injection
tBU.YT.XCU
RZTHOV
BadlonetcT
Badlonwtry
B01BEB
or ctsss
3
at «
bl <

2.9-0.88 ag/nl
a) 23.5-18.7* of dose
b) 7.4-1*. « of dose

Bet applicable
a) 33.1 » or - 3.5*
of dos*
b) 11.7 » or - 5.9*
Of dOM

Initial neasvrenent and 2« hi after
14 nq/sq n, IT.
Cancer patients
MUSS; BIOOB Pl»SH»; VBIBI;
BIOPLlSBSi CBIBOTBEB1PT
at Cnn«lati*e ercretlon of labelled
draq, 0-* hr after 10 nq/sq n, IT
• b) c»9lati*e excretion of anckanqed
draq 2» kr after 10 nq/sq n, IT
Cancer patients
DBDC.S; BLOOD PIlSBti OBIBE;
BIOP11S8S; CBMOTBIii?!
aisais^rara <7,s,-,i.iph..2b,t..»b«t,,5.ipk.,7D.t.,»- fs ^
CT7-S21-B-0»
Bl 303.35, RI 59 C
TISSBS
5085
Urine

ZIPOSOBS BOOTE
Injection
Serial

aBlLTTICtl
RETROD
	 —

BOB1SB
or CUBS

— — — — —
11BGB
a) 7.8-1.0 aq/hr
b) O.S2-0.»5 nq/kr
BE1B
at Bat qiren
bt Bat qiren
__._ 	
a| 2-3 and 5 hr after 200 nq 19 as
kTirobroeide
t) 12 and 72 hr dnrinq transdernal
application, estinated dose 0.5 nq
over 3 daws
Ittinated fron graph
HealthT 16-55 rr olds with kistories
of notion sickness
Side effects: dry noith, drowsiness.
Blurred Tisicn
•BOttSs tISIBZ; DBOO THIS1PT: BSOGS
KFEBIfCB

BcKelvey, E.B.
Lonedlco, B.
in. I.
cbadwick, B.
loo, T.I.
1979
Clinical pkarnacoloqr
and Therapeutics 25(5
pt 11:586-590
HcKelTey, I.B.
toned ico. R.
In, I.
Chadvtek. B.
loo, T.I.
1979
Clinical PharnacoloqT
and Therapeatics 25(5
pt 1)jS8«-590
SSYZSEffCS
	 	
Price, B.B.
schnltt, 1.6.
ncsalre, J.
Shaw, J.E.
Trobonqh, 6.
1981
Clinical Pharnacoloqy
and Tkerapeetics

                                                                                                                                                                                        Ui
-------
M 303.35. If 98 C, BP 187-188 C »t 0.1 ••
                                           89
nssvs

SOB*
Bioo4,
plena

BuosdBE MBfB
	 • 	 _
iBgestioa
Xatraaacal


»8TBCI>
8C


or cms
7


•1MB
a) lot giTen
b) lot glT«a
c) lot glTea
<1) lot given
e> lot giTen


iii*
aj 12.9 + or - 2.2
ag/al
b) 31.3 » or - 3.0
«g/»l
O W.9 * or - «.«
ag/sl
1) 170.* + oc - 62.5
ag/ai
a) 2*2.0 « or - «7.3
ag/al
SB


czimi nroBBHioi
a> *1.2 lie «ft«r 0.19 iq/kg.
1»*««»»1 «oltitioB. * sob tacts
k) »7.1 ,1. after 0.38 .q/k,.
1»*™«»«J *clitio«, 7 subjects
c| 35.0 Big after 0.38 aq/kg.
J?*™»"«J {CTTStals). 3 sabjects
«) 90.7 sla aftec J.O BqAq.
lBtr»asal Mlitiai. 5 sBbjects
rapme/l's^t.-0 -^ "Utl"
^.SrlSiS.!.?"'*" -"•*"••
SlgJiBq^-'ft ?r"' "" M'33 Tt'
JJ^'J81^'1™*10 M08S' »»»wsi
ir.mmn>! "°t"! cos""Tln


BIKBBHCS
•lUiasoa. P.
TBB »rk«. C.
JatlM, p.
Barash, p.
BfClt, ».
1980
Cllaieal mnacology
acd Therapeutics
27(3):386-39«

CI1-B2S-02
B» 312.BB. gp 238-2«2 C (* fora). 239-2*1 C (- fora)
                           3
1ISSH8

5087
Blood,
plasaa








EHOSVBE BOOTE
-
laqestloa









BETBOD
	 	 	 .
Bit









OF CISSS
15






	


BlBGB
a) 1.55-7.55 ag/al
b) 0.95-2.90 ag/al
c) 1.52-«.Bfl ag/al
4) 0.24-1.20 ag/al
e> 0.2»-0.87 ag/al
f) 0.12-0.20 ag/al







(BBR

BUI -
a) 3.90 ag/nl
fc) 1.90 ag/al
c) 3.10 ng/Bl
4> 0.79 ng/Bl
e) 0.*3 ag/al
ft 0.16 ag/al







PISB)

GBinil IBPOBB1TIOB
• 	 ' 	 . 	 	 	
dl 43 K
ettraiiol ** * 3" *' «thiayl
e) 3 br after 30 nq
<) 23 br after 30 ng
lactatiag feaalea la Snedea
!I«BH: IDITITS: BLOOD PL»S1»- ^n.|f
t'CCISTOGHS; COBPtlMITE '
"*11V1TIOBS; UCTKTIOH


MPESBBCB
Bllsson, s.
Hygrao. it.
Jolansson, B.D.B.
1977
laerican Journal of
obstetrics and
Gyaecologr 129:178-18*





— 	 ,. , _
                                                                                                                                                                                       Ui
                                                                                                                                                                                       vj
-------
i^o-t1^.^;^^!:'^?.^,^1^
S533-00-2
SS1"^?***2 sr •>••• f*f r '+ '"«••>• 'v»-2«1 c '- fo™> irowTTiBHi .. 	 --...,n.r; 	
B • J 1* e ^^» •*«
TISSUE
5088
Rilll











BIWSBBS BOBM












Hitmen
SSTHCD
__ 	
Ilk











ioiia
or cis is
15











— iiisi
	 . 	 — 	
a) 0.16-1.50 Bg/Bl
b) 0.29-2.50 ag/al
c) 0.08-0. «5 Bg/Bl
d) 0.16-0.63 Bg/al
f) ol22-ll 10 Bg/Bl
2} Q.06-0.20 Bg/al
) 0.10-0.30 ag/al
it Bone detected
}) lone detected










BE»»
a) 0.51 ag/al
b) 1.05 ag/il
c) 0.22 ag/ll
d) 0.38 ng/al
e) 0.3» Bg/Bl
f) 0.5* ag/al
g) 0.11 ag/Bl
b) 0.17 ag/Bl
1) Hot applicable
j) lot applicable










~ " GIlIBal IirOBBWIOl
,) freaarsiag. 3 hr after 250 ag » SO
ag ethlayl ettradlol
50 ag ethiayl estradlol
c) Prenar.lBg. 23 hr after 250 ag *
50 ag ethlByl estradiol
i? UostBarsiag, 23 hr after 250 ag »
'0 OQ ethlayl estradiol
if Wea.relig. 3 hr after 150 «g » 30
an ethiayl estradiol
fl po«tB«rsiBg. 3 hr after 150 ag »
30 ag ethlayl estradiol
9) Piea.rslag, 23 hr after 150 ag *
30 aq ethia-yl estradiol
i) pistaarsiBg, 23 hr after 150 ag *
30 ag ethiayl estradiol
I) P?eBar»iig, 3 hr after 30 ag
1 Postaaraiag. 3 hr after 30 ag
811* erpr«a«ed before aBd after
feediaa tiae
tactatiag feaale* ia swedea
s«BM: atons: BLOOD PUSH: units
PBOGJSTOSISS; COSPlSlTllS

lilssoa, s.
Johansson, E.D.B.
1977 ,
laerieaa Journal of
Obstetric* aad 	
eyaecology 129:178-18«











                                                                  Ul
                                                                  00
C10-H13-B3

IISSOB
5089
Orlae




5090




1
1
i


"BXPOSBSB soo«
	 -
lagestioa




lagestioa




1
.\ 	 —


1IU.TTIC11
RgTBOD
ec-ic




sc




1
1 	 „_ 	


IBSBIl
or cisBS
80




i




I
i
•' 	 	


	 IlnSS
a) 1.6-56.*" of dose
b) 0.»-37.9» of dose
c) 3.0-88.3* Of do«e




a) Wot applicable
b) lot applicable




1
I
1 	



at 1S.2»« » or -
12. 0« of dose
b| 8.260 » or -
6.9T6^ of dose
cl 23.515 » or -
15.026* of dose


a) »H of dos« (9.6
b) < 1* of dose (<
0.2 ag)




1
1


	 — 6111111 MTOMMI01

a) Debrisoqala
ti «-OH debrisoqnla
c) BebrisoqaiB « »-0!I debrisogaia
0-8 hr eicreticm* after 12.8 ag as
salfate.
Healthy, 18-«5 rr old Ghanaians.
(asted before dose.
CHUGS- saa*i; u«I": RnkBOllsn:
tfTlBCtltfS! IDSltS
a) is debriscojaiBe
H is a-hydrorydebrlswgalne
0-8 hr ca«l»tiTe eicretioa after 20
ag as heiisalfate
70 *g, white aale phmotypel as "poor
,€t»bollter" accotdiBg to capacity to
«-hydroiylate debrlsogaUe BBd
Sfartelne.
BMGS: 1STXSCLISB! SFtlSOLIIIS!
mini coi!»«wi«* BT»W»TIO»S;
"SlTItSSS ITPWOtTCS: WriIPTllMXCS;
ilTHT««t*isi»i wins:
1 IMIMMttSBlC »6SWTS
1 	 . 	 	 	 	

	
BcnsnrcE

woolhoase. >.B.
ILadoh, B.
Hahgoab, 1.
Slcxin, T.P.
Idle, J.B.
Salth, B.I.
1979
Clinical Pharaacology
aad Therapeatics
2€<51S58«-591

laaba, T.
OftOfl, S.T.
Falov, w.
1980
Clinical Pharaacology
aBd Therapeatics
27(«):5»7-5»9


1
•

-------
C22-B29-»-O2
II 339.«8, II 75-76 C
                                                        ea.
                                                                     ,-  „.„


5091
Blood


5092
Flood







5093
Blood,
plasaa












509*
Blood.
plasaa







Ing«stion
'

lagestloa







lagestioa











	
lagestloa






BETBOD
	 . 	 ,
GC

.
oc







sc











	 	 	 .
GC/HS



-


BHIBZ3
OF CiSIS
16


30







14











	 .
8






1MSS
0.15-5.8 ag/100 al


0.13-2.** ag/ai







a) 150-7 ag/1
b) 78-3 .« ag/al
c) 280-95 ng/al
d) 180-38 ng/al












a) 290->1000 aaoles/1
b) 620-920 naoles/1




flEIT

liii
1.03 ag/100 al


0.60 + or - 0.51







a) 63.5 ag/al
b) 36.17 ng/al
c| 170.8 ng/al
d) 109.17 ng/al












- -
a) lot giren
b) lot giren




MGI)

GB I III! IITOBBHIOI ~~
fatal cases ia which only
ttopoxyphene fonad.
Coroners' cases, ages 2-62 yr, froa 3
California counties, cause of death.
sticlde, accidental, or aadeterained.
lltEl; BtUSS; BLOOD; IlCOBOlSj C»S»
•Tsmncs; sncxoE; BBOS IBBSE;
Cextroprapoxypheao poisoning
latalities. ilcohol and/or other
drugs la aost cases.
Coroaers eases, ages 16-67 yr.
lorthera Ireland
Coaa, death
Congestion and edeaa of laags. la
lose, cerebral edeaa.
"JOS; BtOOB: OBIIB; SHICIBBJ »BD«
IBHS8; ItmiB; CUB RISTOBIES-
fCBIISIC 8BDICIM
a) 7 anephrics, 1 aad 2» hr after
dose. Initial aeasnreaeat. 135 ng/al
*J 7 controls. 1 and 2* hr after
dose. Initial aeasnreaeat. SO ag/al
cj lororopoxyphene in 7 aaepnrics, 3
nad 2a hr after dose. Initial
aeasnreMiit. 57 ag/al
d) lorpropoxypheae in 7 controls. 2.5
and 2» hr after dose. Initial
aeasureaent. 40 ng/al
rose, 130 a
-------

C22-B29-B-02
II 339. »8. IF 75-76 C
                                                                                     (COBTIIOED)

TISSUE

5095
Blood,
plasaa


5096
Hood,
•hole







5097
liver







5098
Urine







5099
nine






BXjosoBS BOOT:

IngestlOB



IngestioB







Ingestion







Ingestion







Injection
IngestlOB






mimcii
BIT BOD
GC



GC







TIC
IB
ec






«







Sadioaetry






BOB BIB
OF CaSSS
10



a







a) 16
b) 6*







17







8






B1BGB

85-10 ng/nl



a) 93.75-338.75 ng/nl
b) 99.38-318.75 ag/nl
c) 618.75-1362.5 ag/al
d) 647.5-1*50 ng/nl







a) 1.2-35.3 ag/100 g
b] 0.2-38.* ag/100 g







O.OB-6.99 ng/dl







55-75* of total
radioactivity








lot applicable



a) 217.5 Bg/nl
b) 217.5 ng/sl
c) 1013.75 ng/nl
d) 1025.0 ng/nl







a) 11.78 ag/100 g
b) 9.32 ag/100 g







1.61 * or - 2.0*
ag/dl







lot givea






1 GSBIBiL IBTOE nation

1 and 12 hr after 65 ag dose as
hydrochlorlde 1z/»k. 10 vk
Bcalthy 25-3* yr old sea. average »t
8».« kg
ElOOD; BLOOD PL1SI1: inlGESICS: OBOG
TIZBaPT; COSPmtm 1T110MIDBS
a) ProBoxyphene, before heBodinlysis
b) Propoxyphene, daring henodia lysis
•c| lorpropoxypheae, before
d) lorpropoxypheae, during
130 ng propoxyphene/8 hr, 7 doses.
3-6 hr dialysis following each dose.
Idainistered as hydroehloride.
Inephric 36-55 yr olds.
EBOGS; BLOOD: COBPlBKItB
ITitWlTTOWS; IDBITSS HETlBOtlTfiS:
IBJIBMCmS; KIBWEI DISUSES;
BEBODI1T.TSIS
a) ratal cases in which only
b) llcohol and proporypheae found
Inltipl* drags found in nany canes.
In 9 cases of known dosage, fatal
dose vas 15-65 ng/kg.
Coroners' cases, ages 2-62 yr, froa 3
California counties. Canse of death.
suicide, accidental, or ondeterained.
IT.VIJ. 9BBGS: BLOOB; 1LCOSOLS; USE
•ISTOBIES: SOICIDS: OSOG »BBSZ;
CBILDIM; 19ULTS
textropropoifphene poisoning
fatalities, alcohol and/or other
drags in nost cases.
Coroners* cases, ages 16-67 yr.
lorthern Ireland
cena, death.
Congestion and edeaa of lungs. In
ccne, cerebral edeaa.
BB3GS; BLOOD; UBin; SUICIDE; DBUG
lEOSS; IBEUIB
0-7 dav cnnnlative excretion after
deses of K5, 130 aad 190 aq, oral,
aad 65 ng IT of »»C-la1)elled drug |3
uCl) .

Healthy 21-29 yr old*.
ttUSS; tlalGCSICS: BLOOD pLaSBt;
ItQlYS; CO^PIB&TITB BTlLOh?IOVS:
n«iB: nn.ina.nui »aoioisoropis

~~" B27EBBBCE


Slyvka, G.«.l.
Belikian, l.P.
Ihyatt, P.l-
Beyer, B.C.
Journal of Clinical
Pharnacology
15(8.9) : 598-60*
Giaconini, IC.fl.
Gibson, T.P-
levy, G.
1980
clinical Pharnacology
and Therapeutics
27{») :508-51»






Cravey, R.R.
Shaw, 9.F.
Kakaenra, G.B.
197*
Journal of Forensic
Sciences 19(1) :72-80





---
Carson, D.J.L.
Carson, S.I>.
1977
lancet If 80 17) :8M-897







Gran. L.r.
Scaoa, J.
lay. «.l.
Beltberg, J.
Bodin, l.o.
1979
Clinical Pharnacology
and Therapeatics
26(»l:B73-«82


-------
2-aapfctkaleaeacetlc add. 6-eetJroxy-alpha-aetkyl-.  {•)-  (9 en
  '***"***6 •""' «-~tk««r-«W-~tkTl-.  (3)-  (9 CIt
C1«-B1«-03
H 230. 2C, n 155. J C
TISSUE
5100
Blood.
plaaaa








5101
Blood.
•eraa








EifosatE xomz
lagestioa








lagestioa









i Batmen
BRIOfi
oc








BPIC









•OBBH
or CISBS








-
5









FUSE
a) lot glvea
b) Bot given







	
lot given









mi
a) 67 ng/mi
b| 62 a«/al








»6. 1 * or - 5.6 ng/al









eiEERlt IRrOSRlVIOB
a) Deaa peak at 1 kr, 500 ag doae
b) Beav pea* at 2 kr. 500 ag doae
Flaa 1200 ag aaplrla
tatiMtel froa grapk.
aapirla. KG.!?!""* " T

Bealthy 23-»fl yr olds, faated
everalgkt.
Fines : BIDS mmcrioR:
im-nru«BiioiT touts; IDOITS;
HCtS; BLOOg tLkSBa; CORPllaTITE
FVUOKIORS
Steadv state level* folio v lag 3T5
ag/12 kr on 4avs 11 to 20 of
•atateuaco dose of mtfarla (10 ag
dally). RO effect OB boud or free
(taadv-state varfarin levels. Wo
effect oa protkroabla tlaes.
Eealtky 25-C< yr olds, «t 7».1-88.5
tg.
muss: iniccismins:
IBTI-TmiBRtTOBT 1GERTS; BtOOB
SIRO^; IDDITS; COBPUaTITt
tvjtnttiois

BBnBBBCI
	
Segr«, E.O.
ckaplla. B.
Forcklelli. B.
sevelios. H.

aad Tkerapeattc*
15 «) : 37B-379




Jala, 1.
Deflation, r.6.
Slattery. J.T.
1979*
Cliaical Pharaacology
aad Tberapeatlcs
25(1):61-«6





2-pipccliiaeaoetlc adl,

C13-H17-I-02
Bf 219.31
iissg:

5102
Bloo4,
aeraa










5103
Blood,








MMSORS BODTB

lageatloa










Taqeatioa








lllLTTICkL
RXTBOD
	
BPIC









	
HPIC








•OBBSB
or CISBS
2










1










a) 590-200 ag/1
b) 0-320 ng/1









	
0-85 vg/1










a) lot given
b) lot given










lot applicable









Cintll IirOHMTlOi
a) 1.0 »ad 3.S kr after
aetkylpkealdate. 35 ag 3x/day.
iBltlal aeasareaeat. 220 ag/1
tl Initial aeasoreaeat aad 2.2S kr
after aetkylrkealdate. 10 ag 3T/day.
Tlaal aeaavreaeat, 210 ag/1 at 4 kr
latlaated froa grapk
Sltalinic acid aetabolite of
aetkylpkeallate
Bfperactlve 9 aad 1* yr olda
CHT10SBI; SU»VIOS BISOEDEBS; BLOOD
SIBO»: »RTIMPRJSS1TE IGEBTS; DSOGS:
«laSO»E«E»I HITBOBS: RETiBOLISN;
BlllBOlITfS
Initial valae and 2.0 kr after 15 ag
dc»« of aetkylpkanldate. Fljial value
25 ag/1 after 8.5 kr. Vstlaated froa
grapk. Bitallalc acid aetabolite of
aetkylpkenidate.
Byperactlve 12 yr old
CBTimER; BEB1TIOB DISORDERS; BLOOD
SIBOH: MTIBEPBESSITE AGESTS; DBDGS:
H«S»BE9StT HE»BO»S; 1BMBOUSH:
BITIBCIITIS

BErEBERCB
Soldla. S.j.
Bill, B.B.


BUI. J.G.
1979
Cllalcal Chealstry
25(1)s51-S»





	 	 _
Soldia. 5.J.
Ckaa, 7.—P.H.
Bill, B.B.
Svaasoa. J.».
19T9
Clinical Ckeaistry
25(3):«01-«0<




-------
2-PiperldiBeacetic «dd. al»ba-pb«Byl-. ""tkyl ester
113-M-1
C14-B19-B-O2
II 233.10. U 7«-7S C
TISSU!
510*
Blood.
serai
EIPOSHB BODTB
InOeSt iOB

1M1TTIC1I
RETBOD
BPLC
•

BOSSES
or cisis
1

B1B6E
a| CS-0 09/1
b) 82-21 Bg/1
,,_ 	 , — — 	
1B1I
a) lot girea
b) Rot glren

GEBEB1L IBTOSHBTIOB
<) 30 Bin and T he after IS *J
t) BItaliBic «cid (Betabollta) . 2.5
and 8.5 hr after IS ag
aethrlphenidate
istlBBted trca graph
Byparactt*e 12 re old
CBIIDBEB: BEB1TIOK OISOBDBBS: BXOOD
SIBOS: aSTIDmESSITE WlltSj DBtJGS;
«»SBFBiBBT IBTHODS; RRIBOIIS*;
•nUOLXflS
BEFEBEBCE
soldln. S.J.
Chan, Y.-P.B.
till, B.B.
SwaBSOB, J. 8.
19T9
Cllalcal Cheslstrr
25 (3): 401-404
C1«-B21-«-02
   259.3«, » 96 C

1ISSOB
5105
Blood,
plasaa
5106
Blood,
plasaa
5107
Blood.
» 	

BXPOSOBS BOOTE
Ingestlon
lagestloB
ngestion
n lection


IBllRICli
IBTBOD
rlBoroBCtry

oc/as
\
1
\
—\ 	

BOIBEB
or cisss
12





a) 17-140 ng/nl
b) Bot gi»«B
c) »ot gi»en
a) 571-2* BBOles/1
b) 79-44 BBOles/1
a) 13-1.4 ng/nl
b) 8.0-1.1 ng/nl
c) S5-3.7 B9/B1
— (Bt,r

	
a) 48.6 ng/nl
b) 77.2 * or - 11.1
c) 41.4 » or - 9.4
a) tot glrea
b) Cot 9i»en
a) Bot glrea
b) lot giTen
c) lot glyea
t tiif\


a) Before s«rgery " "c.lllster. E.G., Jf.
r) it the end of surgery, corrected 1 Bonrne, D.w.
for dilation 1 *«' T- «• ,
c) 10 alB after bypass dlacontisned 1 Ericteon. J.L.
Dose. 40-320 aq/oay to 12 hr before 1 VBchtal. C.C.
surgery, b) different froB a) and 1 T|**' !>p-
Waits OB long-tew propraaalol 1 and TherapeBtics
therapy for angina pectoris. 1 25(1) n-7
tndargoing aorta to coronary t
•rtery-saphenons »ein bypass sargery. 1
CBUGS; o^ne 7BSBi?T; siooo nisii; 1
ITOITS: BBlBt DISUSES: SOBGEBI 1
a) 2 BBd 24 hr neans after 16 ng/days I Johansson, S.B.
t) 16 and 24 br Beans after 160 1 •=C»1J» "•
US/day la slcn-release fors. 6S 1 WllhelsssoB, C.
iioles/1 at 2 hr J *|*Jn' 3' '
Bealthy 20-30 Tr olds, rithln 1M of 1 CliBical Pbarjacology
---—-I fjalnlifr 1 •&« TftBjr4p*tttiCS
Bcrsal .eight. f 27fS).M3.601
Bcdaced resting heart rate and 1
cierclse-lBdnced tachycardia. 1
reduced tlood pressare. I
ETOGS; SIECIBi BLOOD PLlSHt; t
•STIBieWTIBSlTE 1SSWTS: COSPISWITE 1
nitoiiions: molts: BLOOD PBESSBRB i
•) Initial Bcasaresent and T2 hr 1 walle, T.
after 0.05 sg/Xq IT. 3 soblects 1 Conradl. I.e.
t| 2 and 1* he after 20 ag, oral. 1 Halle. O.K.
Initial aeaeorenent. 1.3 nq/al 1 Tagan. T.C.
e) 2 and 16 hr after «0 Bg, oral. 1 Gaffney. T.J.
Initial aeasareBeBt* 5.4 ng/Bl 1 *979a
B«ge of «.« "rtliated fros graphs. I Clinical Pharaacology
tata also available for loag-ters 1 and Thera pent Ics
aoses «« for napthoiylactlc acid 1 26(5) :548-SS»
(Bitabolite) . <
\
KcalthT. 22-30 yr olds. »t 6J-S3 lq. t
IGWtS; »lOOt PI.BSBM TOIBE 1
1 	 	 	 .» 	

-------
2-Propanol, 1-(isopropylasinol-3-(1-naphthyloiy) -  (8 CI)
2-Propanel, 1-<(1-iethylethTl|asino)-3-(1-na)>hthalenyloxr)-  (9  CI)
525—66-6
C 16-B21-I-02
II 259.34, BP 96 C
                                                                                      (COHTIHDED)
HSSOB

5108
Blood.
plasoa






5109
Blood,
plasma








5110
Blood,
Flasaa























5111
Blood,
plssoa







.



El POSH BE ROUTE

Inqestion



















Inqestion

























Inqestion












aULYTICAL
HETHOD
Fluorometry








GC










HP1C

























Pluoronetry












mjHBBH
OF C«SBS
s








25




































7












sues
-
a) 45-222 ng/al
b) 37- 28J no/«l







5-121 ng/Bl










a) 2-7 ng/Bl
b) 13-51 aq/ll
C) 57-279 ng/Bl
4) 19-174 ng/nl
e) 534-170 ng/nl
f) 1667-509 ng/Bl
9) 15-8 ng/Bl
h) 4372-4288 ng/ml

















_. _ . . . _
a) lot given
b) Dot given
e) Dot given










-
IBM

a) 169 » or - 72
nq/Bl
b) 169 « or - 79
nqyul





lot given










a) Hot give
b) Hot give
c) Sot give
d) Hot give
el Hot give
f) Hot give
q1 Hot applicable
h) Rot applicable



















ng/Bl
b) 93. S * or - 44.8
nq/ll
o) 115. 1 » or - 56
nq/ml








SSHSBit IHFOSBaTIOH

a) Propcanolcl
h) Propranolcl 4. qnlnldlne
Ivecaaa steady state 0-6 he after
80-«q dose. Qainldine dose, 200 mq.

aealthy 22-H6 yr olds.

CHUGS; DRUG IRTERaCTIOH; BLOOD
PH31J: JHTIIHBHTTHHIC JGESTS: >DH1TS
tcse, 1$0 oq/day.

Thrcotoilc 17-65 yr olds.

nausea, lethargy, insoania.
ligbtheadedness, and diarrbea.
Cecreased neart rate, vt change
sl9nlf Icantly related to plasma
levels.
D1ITED KIHCDCI: BLOOD PUS HI; DBBG
TEEB1PT; DBDG5
a) 0.5 and 2 he after 20 nq. 3 ng/sl
at 8 hr
b) O.S and 2 br after 80 ng. 18
nq/al at 8 hr
c) 0.5 and 2 hr after 320 mq. 118
nq/il at 8 hr
d) Raphtboxy lactic add (HIA) ,
letabollte, 0.5 and 2 hr after 20 ing.
40 nq/nl at 8 hr
«) HL> 2 and 8 he after 80 19. 242
&9/B1 at 0.5 hr
f) Hit 2 and 8 br after 320 nq. 705
ng/nl at 0.5 hr
g) Before and after heBodialysls,
unspecified doses
h) H.I before and after heiodialvsis
Given as hydrochlorlde
a)-f| locial dales. Other
•etabolltes also aeasured.
6 nornal 23-32 yr old Bales, fasted
before and after dose. 14 21-65 yr
o!4s on long-term hemodlalysis.
IHTIHTPSBTIRSIVB aSBHTS; DRUGS;
BIT1BOI.ITBS: BLOOD PtSSIS; PPOTMHS;
tPISB: KTIRET DISEtSES: HEBODIiLTSIS;
ItOlTS

hydralazlne
e) Peak, propranolol * SO aq
kydralazice
Cata also for absorption studies.

Horootensive 19-31 yr olds, vt 4«-90
kg, fasted before dose.
Decreased pulse rate, blood pressure.
Faintness with hyiralazine plus drag.
imttYPBRTtHSIVB IGBBTS; BLOCD
pitsii: 1BDITS: Ditne IBTEB»CTIOS:
ELOOD P!tESSnKE: EHZTKES: ltiSTBM.Il
BEFEBEHCE

Fenster, P.
Perrier, D.
Hayersobn, H.
Rarcns, F.I.
1980
Clinical Pharmacology
and Therapeutics
27(») :4SO-4S3

Feely, J.
Stevenson. I.R.
Crooks, J.
1980
Clinical Pharmacology
and Therapeutics
28(1): 40-44




Schneck, D.H.
?ritchard, J.r.
Gibson, T.p.
Vary. J.B.
Bayes, S.B.. Jr.
1980
Clinical Pharmacology
and Therapeutics
27 (6): 744-755

















ffdean , &.J.
Skevs, R.
Eobik, 1.
Dudley, P.J.
1980
Clinical Pharmacology
and Therapeutics
27(6):726-732






                                                                                      (H3IT
                                                                                                                                                                                            OJ
-------
2-Ptopaaol. 1-oJ-3-t1-Baphthal«Byloir»- 19 CI)
525-66-6
CK-B21-I-02
II 25*.3». IP 96 C

TISSUE
5112
Blood.
plasaa









5113
Slood,
plasaa









Blood.



5115
Blood,




nposniB BOOTB
Injection









lagestioa









Ingest Ion



iBlOCtlOB
Tagestloa




• MlYTICAl
BCTBOD
Flaoroaetry









ec









Flaoroaetry
ladioMtry



Sadlosetry
Flaorosetry




BDRBBB
OF CASES
10









24









IS



5





•) 25.4-24.3 Bg/al
b) 31.3-31.7 Bg/sl









a) 5.5-152.5 ag/al
b) 56-290.0 sg/sl
c) 97.5-580.0 ng/al
d] 67.5-1,330.0 ag/al









3.2-15.6 ag/al



a) 30-63 Bg/»l
b) 39-142 eg/si




a) Vot glvea
b) lot girea









a) 69.4 ng/al
b) 158. 1 eg/al
c) 339.0 ng/al
d) 607.6 ag/al









5.40 ng/al



i) 41.5 ag/al
b) 79.2 ag/al




a) d-Propraaolol after iafMloa of
d-fora
b) dl-Propranolol after infusion of
dl-fora
1-4 br range during 4-hr Infusion of
0.04 ag/kg/hc
Data shov that propraaolol depresses.
•ithovt altering the glucose carve.
glacose-stitalated insulin levels.
lealthy. noa-obe»e 25-37 vr elds, oa
SCO g carbohydrate diets >3 days.
dl-fora redaeed blood pressure
rsoes! BLOOD PLUIA: CMIOI:
BITISOII5B: ELOOO SEBDB: BOtBOHBS;
HOOD P»«SSOBB; ABBTTS
a) 40 eg 2i/day
b) «0 ag 2x/daT
c) 169 ag 2i/dar
d) 2*0 ag 2 I/day
t.*-2.S hr after aornlag dose

2«-62 yr olds, «ith essential
hypertension.
lever blood trestares and pulse
rates. Fatigue, di«laess. chaage in
tovel habits, algbtsares.
IS9SS1 91106 TBBPaPT: ABTIBTPBBTESSIVE
leiirs: SIOCB PBISSOBS: BTFIPTEISXOI;
It BITS: MItIB HBGBOS; CO»P»BIH»E
tmOkTTOWS; MUSES
	 — 	 — 	
Steady state levels after 7tb dose of
«0 ag/8 br. aad 40 ad of
3B-propraBOlel IT
Icraal 23-55 yr olds, vt 56-92 kfl.
esucs: BsriBoiisi: IDCLTS; BIXXJE:
BtOOD P11S!11; AICOROLS; SSISBSSBWT

a) stealy state, 80 ag/8 hr
r| Stealy state, 80 ag/8 hr plas
eblorprosailBe. 50 aq/8 hr
Idalts, 4 aoraal aad 1 hypertensive,
ages 21-33 yr.
giOGSt 9B3G laTEHCTTOI; TZ*nSS!3;
ctocQ pits'i: aooiTS: BT?tsrt«slol;
ilFEBEfCB

Brers, B.C.
Bope-eill, B.P.
1979
clinical Pbaraacology
and Therapeaties
25t3):303-308









Serlin. B.J.
OrM, B.l'B.
Baber. l.S.
SibeoB, fi.G.
Lavs, t.
BreclceBridge, A.
1990
Clinical Phanacology
and Therapeaties
27 {•!): 586-592






xonha«s«r, 9. B.
vood, l.J.J.
yestal. B.E.
Wilkinson, c.e.
Branch. B.A.
Sband, D.6.
1978
Clinical Pharmacology
and Therapeaties
23 (2): 165-174
vestal, B.E.
Korabaaser. 3.8.
Bollifield, 3.9.
Shand, B.C.
1979
Clinical Pharaacology
and Therapeaties
25 (1»: 19- 24
	 	 	
(•Bit PIGI)
-------
Bl 2S».3«.
IBSM
S11C
Blood.
»!•*••
5117
Moo4,
5118
BlooA.
5114
Mood.
*«r»«
5120
Blool,
whol«
"BIPOSIB BORI


Hontloi
	 	


luiTTIOU 	
HBTBOD
ec/is
BUG
n»oroi«try
B»LC

or cuts
-
5
3
35
_
•1 S
»l 2
ct 1
4) 1
IS
(con
	 file? 	 	
b) 75-2*9 »o/»l
c| 73-2SO mq/ml

•- 	 	 	 	 	 .
C-31C n»/.l
•) >0-57 ng/ol
b) 50—80 kf/ol
c) lot «pplie«bl«
<) *ot cppliabla
33-1W sg/tl
II KIT
'Itno)
~ JB1B f
	 	 	 	 __l.
•1 63.6 ig/.l j
b) U2.2 •«/•! !
Cl 1*2.2 4/.1 {
1
I
Wot 9iVM *
1
i
i
|
Bot giT*» !
'
!
1
j
J
1
1
1
	 	 _!.
«l Bot given i
b) Bot givoft |
c) 120 Bq/il i
d) 212 no/il i
J
J
•
J
	 	 	 	 1.
72 nj/,1 J
1
1
I
1
Bleu! " • — 1—
                                                                                «inu
                                                                                                         MFBBBICE
                                                                          assrsatr— ••—
                                                                                       itpzmisioi:
                                                                                       M; CO«»lB*Ttl
                                                                                      nts»: OBIM
                                                                          SSL
I i^*SrCk CO"»«iC«tiOB
'  " i^Iif?1 ?«t««oio,,

                                                                         co.plTi.,
                                                                                                                      Ln
-------
-Baphtbyloxy)- (8
JSS-6S-6
C16-B21-I-02
II 259.3*, BP 96 C (COIIIIBBD)
iissns
5121
Urine


5122
urine







5123
urine





EtfOSUSI KOOTB
Ingestion



Ingestion







Ingest log





IMLTTICIL
BBTBOD
GC/BS



HM.C







ec/ss





or cisis
5











2«





B1IKB
lot given



a) lot girea
b) lot given
c) lot giT«n
d) lot girea
a) lot given
C) lot giTCB







a) lot gives
b) lot giv«B
c) lot given
d) lot given




BE1I
Ik* it dose



a) 8. 3 * or - 1.6* of
dose
b) 13.5 * or - 2.S*
of dose
c) 15.0 * or - 6.5*
of dose
d) 39.2 » or - 2.8*
of dose

£) aa.6 * or - 5.2*
of dose




a) 3. 1* of dose
b) 9.2* of dose
c| 16.0* of dose
d) 18.0* of dose





tally excretion OB chronic therapy of
eo to 960 ng/day (every 6 kr) .
Hypertensive patients.
DB0GS: SSTIBOJ.ITBS: IBTIHYSBBTEISIfB
IEEITS; BLOOD PtlSBI; OBIIB

a) Propraoolcl, 67 naole dose
B) Propranolol, 268 ««ole dose
e) Propranolcl, 1072 nnole dose
d) Propranolcl » setaboUtes. 67
anole dose
e) Propranolol * aetabolites, 268
f" Propranolcl » setabolites, 1072
stole dose
Given as hydroehloride
•8 hr excretions
lorsal 23-32 yr olds, fasted before
and after dose.
MTIBYPESTBISiyE IGBSTSi DBOGSs
JITtBOlITIS; BtOOB P11SB1; PBOTEIISj
OBIIB; KIOlEy DISEtSIS: BEBOBI1LTSIS;
lEOlTS
— 	 — 	 " "~
a) «0 ng/day
b) 160 sg/day
ci 2*9 eg/day
d) 320 ng/day. * excreted daily as
the glnearonide after long-tern
tterapy *ith dose indicated.
Bypertension or coronary artery
disease patients.
CBGGS: B8UG TBTTglPT: BTPEBTBBSIOWi
C»SBIOT»SCTO»B OISEAS^SJ COBPIBITITE
M»IIHTIO*S: BIOOD pisssi: OBIIB
	 	 — — • 	
~ TirEBEHCE
	 — 	
walls, T.
conradi, B.C.
•alle, O.K.
Fagaa, T.c.
Gaffney, T.S.
1979 a
Clinical Pharaacologv
and Tkerapeoties
26 (5) : 5«8-«»
Schneck, D.«-
Pritchard, J.P.
Gibson, T.J.
Tary, J.B-
Bayes, 1.8., Jr.
1980
Clinical Pharsacology
and Therapeotics
27{6):7»«-755







Halle, T.
Conradi, B.C.
valle. U.K.
ragaa, T.C.
Gaffney, T.E.
1979b
clinical Pharnacology
and Therapeutics 26(6):
686-695




-------
13*55-52-2
C 1S-B23-W-02
II 2«9.39
            i-co-BllylpheBoxT)-3-{i*opropTlaBiBO|-  (8 d)
            1-}<1-BeihTlethrlU«i«o)-3-(2-{2-propeBrl|phe»«r}-  C»CI)
tissai
512»
Blood,
plana
5125
Blood,
plasaa

IZIOSnC SOBTB
Inqestioa
Infection
laqestion

iiiinicu
nraoD
ec
GC-SC

•DHBIS
r cisss
1
1
«

iiiii '
a) 29-90 BBOlAS/1
b) 8-9 » aaoles/1
C) «-122 BBOles/1
4) 22-9* BMles/l
a) 100-15 FBoles/g
b) 37-12 psoles/g
c) 115-3* caoles/q
4) 125-12 naoles/g
e) 200-6. 5 pnoles/g

	 5Ii 	 i "" GEitMi nrosHttioi i SEfEBEics
i j
a) «0 BBOles/1 ! •) alprenolcl. 90 .la after 0.2 q 1 «"f*«; p'
b) 38 ».ol«8Xl 1 b) Ilpra«olol, 90 .i» «ft«r 0.2 g. 36 !«"«»• p-
c) 80 naoles/1 1 »t after last ot 10 doses J Borg. K-o.
?> ss »«ol*a/l 1 i«atobacbltal (0.1 g/Say) » "aglanfl. K.
4) 55 .iol.s/1 1 *«"™j;4ro)tj..ipl.1. 90 ai. after 1 »« Bahr. C.
l fl 2 a ^ i9'9
«i 1 a?kTae8«I-al|,r.»olol. 90 ai; after 1 "Vi"!^?"01*"
i 0.2 q. 3« ar alter last of 10 loses 1 «a.;k!"*«£ie8
| peatobarbltal (0,1 g/«aT) 1 25(«) :«23-«27
| t«*tobarbital effect OB Beaas 1
| siqviflcant. P<0.01. 1
i «
I ICBsaolciaq 23-31 TT olds, nith BO 1
1 «Tl4euce of iis«ase or flrog Intake. 1
| iBhibltloB of exercise tacblcardU 1
I taring » 7 he period vas reduced froa I
I «.0 to 10.7* br peatobarbltal 1
| (redectloB correlated »lth plasma 1
1 levels). '
tines; HBTIBCLISB: BWTSIS; I
BTTn^nsToi: BLOOD PLISHI: C« In eierclse heart rate 1
correlated «ith log plasaa lerel. 1
CSIGS: stfMii: JLDHWS: HIPEBIBSSIOH; i
HTlBOtltlS: BLOOB PLtSHl; IBOTIUS 1


     2S839-7S-8
     C13-H«-i»-03-S
     II  31«.»Z. HJ 71.5-72.5 C

1ISSHI
512«
ElOOd,
plasna

sxrosnfts some
-
lagestloB

alliniOL
HCTBOO
OC-BC

IOHBSK
OT CaSSS


BMGB
173-3 BBOlesA
i»1
Rot giTen
GIlIBlL Iir08»»TtOS 1
2 «aS ao he «eins after 20 eg/day
Sealtby 20-30 Tr olds, within 10« of
noisal weight.
Seduced resting aad exercise heart
tates. Seduced tlood pressure.
Etaes: snosi: BIOOD PUSIII:
laTIHTPIITWSITI 4GEMTS; COnflKWTYE
gt»LUlTIO*S) 1DQ11S: BtOOD IBESSttSI

Johansson, S.F.
HcCall, II .
wil&elasson , C.
Tedln. J.I.
1930
clinical Pharaacology
and Therapeutics
27(5) : 593-601
(IE1T PISE)
-------
                                     ^^
J6839-75-8
C 13-B2»-««-03-S
81 316.»2. BS 71.5-72.5 C

1ISSOC
5127
Blood,
sera*







5128
Urine







EtPosnBS SOOTI
Inaestion







IngestioB







ilaLTTICIL
BETBOD
GC-SC







GC/HS
Radionetry





_____ _— — —

BOBBBI
OF C1SES
IS







3







IMSB
a) 0-86 ng/ll
b) 30-156 ng/n.1
c) 39-171 ng/«l







lot giTen







Bill
a) 42 ng/al
b) 77 ng/*l
c) 96 ng/nl







77 * or - »% of dose






J__._ 	 ' " —

a) 20 *g/aay
t) ao sg/day
e) CO nq/day
Ifter 3rd week. 2-« hr after M dose.
23-56 yr olds, slid to soderate
etsential hypertension , » no-25 yr.
C black. 11 unite.
flood pressure, heart rate, and
plasia renin actirtty decreased.
EBDGS; oans THSR»PT: HTPMTIISIOK:
IIOCD SE^OB; conPatwiys iy»toatio»s
lose. 10 nq C1«-ttnolol
2* hr excretions
Bealthy yolnntears
I)BIR«: 1TT1BCLISS; SMS; DSOCS





SEFESEHCE

Slnoa, 6.
Kiowski, >.
Julias, s.
1978
Clinical Pharnacologl
and Therapeutics 23 (2) :
152-157





Tocco, D.J.
Duncan, i.E.V.
delnna, F.I.
snith, J.L.
Falker, S.».
TandenheaTel. S.J.*.
1980
Drag Hetaboliss and
DispositiOB
8(«) : 2 36-240

2-eropaBOl,  1-(2-CTClop«tilpliei»»r»-3-( d.
3«507-aa-9
C18-B29-»-02
R« 291.*
                                                                                                                                                                                  00

ussm
5129
Bloo4,
plaaia
5130
Urine


IIPOSDIE BOOTS
InoestloB
Inoestlon


»»»tmc»i
CETHOC
HaoroKtrT
Flvoroietrr


ID8BES
OF C1SSS
12
12


MICE
a) 403-3*56 ng/il
b) 37«-2191 »g/«l
c) 283-661 ng/»l
a) Rot given
bj lot gl«en
e) lot gi»en


> ' \
a, ,239., . or - 225 j »*J.;«e'«.Ti.^S,tta" \ ~">,
7 * °' - '" oS^r'.^.r,^^,— ^ ! SSK.^.
SS" * or - 31-7 i ?-^s- ^."i^.1"1 ""* i SFt! J:T-
1 HsalthT 21-«S yr olds. »t 160-180 I Joarual of =li=ic«l
! lb""o iruqs > 10 4ars. fasted 1 Phar.acolo, y 19:«15-a23
I before and after dose. 1
j HeJnctlon in restinq and eserciae 1
i heart rates and systolic pressure. 1
1 giastolic effects less consistent. 1
1 EFUSS! »ITIHIPWT!»SITI »SI»TS: BLOOD I
| H'SSflBS: BLCO9 PllSBi: OBUI; IDOITS 1
1 	 _ 	 	 	 	 ] 	 	 	
Swis ilH-lL .,„»... liife,.
. • t HOTOSt *• E«
•ealrty 21-»5 yr olds. «t 160-130 t ftevart, J.T.
1 Its. «o *r«gs > 10 ««ys. fasted 1 1979
before a.« a«.r do«. . *:~^,^;^t«l
I telnctioa IE restlaq and eiercise 1
I heart rates and systolic pressure. 1
I Clastollc effects less consistent. 1
i '
1 C*0es-. MTlSWCTtWISTT! \G!«TS: BIOOD 1
1 H'SSHT1!: ?1COB M.»S^\: T!SI*t; WOltS I I
1 	 	 	 — — 	 ' 	 '

-------
CH-B25-B-03
It 267.3*
TISSOX i nrosBBB Boni"

5131
Blood.
Plasaa





5132
Blood.
plasaa











5133
Plasaa








513*
Plassa









iBoestioB





Ingestloa











iBOestioa








Tagestioa








lUlTTICal
HBTBOO
SC





8C











SC-BC








9C-SC









or CISBS






5











a) 12
b) 8

















lues
•I 1237-20 Beoles/1
b) 605-56 BBOl.s/1





a) 27.1-76.1 paole/g
b) 53.5-1*7.7 paole/g
c) 162.6-aio.S piole/g
4) 130.6-199.B peole/g










	 , ...
a) Bet given
b) 111-325 eg/el








a) 68.1-«67.1 ag/sl
b) 120.S-1C66.7 ng/sl








OESI
a| Bot gives
b) Bot gives





a) 60.0 psole/g
b) 106.1 paole/g
c) 265.8 psole/g
4) 166.5 paole/g











a) 323 « or - 98
b) Bot given








a) 198.9 « or - 37.7
b) «26.1 + or - M.I

(S.S.J






(MIT Pas*)
SBBHB.1 I,™.,™,
a) 2 aad 2a lr seaas after 200 tg/day
b) 2 aad 2* hr seaas after 200 sg/day
a» slov-relcase fors
Bealthy 20-30 yr olds, withia 10« of
•orsal velght.
tadaced resting aad exercise heart
rates. Seduced blood pressure.
MOSS; StIDZI; BIOOO PLlSfll;
• RlBt*EBTI(SiyZ iGtltS; COBPlBaTIVB
iTaLn*no«s; iDviTs; HOOD PKSSTOZ
a) 25 ag/day, 2-5 days
b) SO eg/day, 3-7 days
c) 100 ag/day, a-9 days
d) 50 ag 3z/day. 25-72 days
iverage levels for 1st 7.5 br after
dose, (area-aBder-tae-coxve/tlae) .
30-«6 yr olds, witk hyperteasloB
0.5-3 vr.
iBtlByperteasive at all doses, p <
0.05, lomred palsa rate, all doses.
c < 0.01. B.Hi pi. doses lomred
Flasaa renin activity IB a of 5
eases.
tlOGS; OIOG TBKSiPI; BIOOO nESSQBB-
lIlIHTPBBTtBSITZ KBITS; SVBDEB;
atTltS; COaplBlTITE ?T»LU»TIOIS;
XTCOD msvi
— — 	 	 	 	
a) after 1 «k oa 200 ag/day.
tiastollc iressere responsive to low
dose (qroap t)
b) 1 and * vk. Dose 200 sg/day 1st
«k, 300- BOO eg/day *th vk. Olastollc
rtessere respoasive oaly at higher
doses (qroBC B>
Ul s«*1ects given 50 ag 2I/day
hydrocBlorotUazide > 9 vk before
ictoprolol.
21-« yr olds. »t 55-105 kg, vith
tlld to soderate hypertension.
It diced blocd pressare, redacel heart
late aad plassa reain activity.
tlzzlaess aad fatlgae.
rsness BTPS»TBBSIO»; 91000 pizssnas-
BWSBTICS: IBTlBIPEBTEllsiyi 1C! UTS;
BIOOB PHS1I; 1DDITS
a) Jfter single, 100-ag lose. Peak
at 1.7 » or - 0.2 hr

10C-600 ag/day. Peak at 1.6 * or -
0.2 hr
adsialstered ai tartrate.
Rynerteisive 30-69 yr olds, fasted
before first dose.
Elaed pressure and heart rate
decreased .
EBOSS: DIDO TBMIPTS »BTiBtsz»TWsiyi
16SBTS; HYPmiBSIOII: BtOOD PllSKt;
EICCD PMSSIJUE; CIMIDI; 1DVLTS

BBTESERCB
-
Johansson, S.E.
Recall, a.
Vilhelsssoa. C.
Vedia, J.i.
mo
Clialcal PharsacologT
and Therapeutics
27 (5): 593-601



Collste, F.
Baglaad, (.
VOB Bahr. c.
1980
Clinical Pharaacology
aad Tierapeatics
27(«):aai-a«9









yelasgnei, a.T.
Van, S.R.
Haroade, B.r.
1979
Clialcal tharaacology
and Therapeutics
2«(5):'!5?-561








Ryers, U.S.
Thiessen, J.J.
1980
Clinical Pharaacology
and Therapegtics
27(6)8756-762







                                                                                                                                                                                     vO
-------
2-Propa.ol. ,
37310-58-t
C1«-H25-«-03
•I 267.J«
(COiTHBED)
1ISSOB
5135
Blool,
Flasia
-
5136
Blood.
plasaa
5137
urine

1IPOSDJK HOOTB
In oast ion
Inoestion
-
Inoestion

IMLTtlCtl
HRBOB
ec
OC
ec
Saaioaetrr

IDIBSB
or cisss
C
B
10

	 HteB
a) «ot applicable
b) lot applicable
e) lot applicable
a) 360-1200 naoles/1
b) 230-1100 moles/1
a) lot applicable
b) lot applicable
c) let applicable
4) lot applicable
	 — 	


a) 135 »J/»1
b) 77 ng/al
c) B9 »g/«l
a) tot glten
b) tot giten
a) 2.7« of dose
b) 3.5* of dose
c) 97.5V of dose
4) 99.6? of dose

                                                                                                                   a)  Bean pea*. 87 »u'
                                                                                                                               . 2*0 "i
                                                                                                                   tablet  (59«  released by 2 »«
                                                                                                                   e*  lean pea*. 28i .i», slo. release
                                                                                                                   tablet  (3»«  teleased b» 2 hr>  -
                                                                                                                   180 ml. single «««• •• tartrate.
                                                                                                                   Be.lthT  23-2J »«•"
                                                                                                                   bt b«for«  ana » fcr aft«t

                                                                                                                              caused MXia»  17-
                                                                                                                   rat*
                                                                                                                   Iffwt.
                                                                                                                   l*r*ls.  r>9.9«.  K0.001.

                                                                                                                   DB»«$! 9100B tlURll 3SHJ
                                                                                                                   CC9VM1TITI IT110HIOSS:
                                                                                                                   SKBEir;  BlOOt PSZSSBRB
                                                                                                                   a)  ?eak».  1-3 »' «"« «-' *   JS hr
                                                                                                                   t  P«ak«.  1-2 *r alter 0.1 9.  36 hr
                                                                                                                   aft«r 10  «aT« i««tobarbUal 10.1

                                                                                                                   Ke.-U«l«-t»e-c,rT. r.4«rt by
                                                                                                                   after paatobartital  treat««nt.

                                                                                                                   BealthT Swedish «t«d«it8. ages 2*-37
                                                                                                                   ", no«*ao*er«. tast.a OTetalqht to 2
                                                                                                                   it after «OS€.
                                                                                                                   tunes-  DSOS nrwictioi:
                                                                                                                   "MD MisS»: BIOOD misson:  S«B»M:
                                                                                                                   IC1LTS
                                                                                                                                «toprolol.  slo«-r.lease
                                                                                                                            ^e  aetoprolol.
                                                                                                                            riatoactiTitT. slo.-r.lease
                                                                                                                         *  raaioactiTitT.
                                                                                                                   72 fcr etcretloas after 50  •«
                                                                                                                   ttitl««-labelle4 d«» as tartrate

                                                                                                                   10 lieaXtiT 25-*6 Tr oias.  fastea
                                                                                                                   10-12 hr 1-«t<:r« » • fcr aftet aose

                                                                                                                              caaael «aiiia»  17-19t
                              rate.  »•*«  »!»» »»
                              J«ects eorr.late4.ith
                              ItTels. r>0.96. P<0.001

                              E»ieS! BIOOB Pl»S8»:
                              cei«»i»TiT!  miowt
                              SISDIW, BtOOB  PHZSSOW
                                                                                                                                               »»loes-
                                                                                                                                              m.,,
                                                                                                                                            »BOHS:
                                                                                                                                                                   c-s.
                                                                      icta  pharsacoloqlea et
                                                                      toiieol09lca36(Suppl
                                                                               I.
                                                                      seiaeian. P.
                                                                      Collste. S.
                                                                      Borq, r.-O.
                                                                      von Bahr. C.
                                                                      «79
                                                                      Clinical Phar«acol09T
                                                                      as3 th«tapeatlcs
                                                                      26 (3) s 326-329
                                                                      teqaraii. C-B.
                                                                      johasson, 6.
                                                                      Jordo, 1.
                                                                      SoUsll. 1.

                                                                      »cta ?iar«acologica et
                                                                      Tozlcoloqica 3*
-------
2-tropes-1

C1«-B1T-Br-B2
•1 317.25
3- C-broaopV..,!, -..„,,..«,,„_ ,3.pyttai.rl, _, (J),
                                                                                     •ot glre.
                                                                                                           lft.r  50 a, HeeUdiB.. 31/dar. 3-6
                                                                                                                        "Uh
                                                                                                                                 °*
                                                                                                           ..  *---	r--*-*^f aaasea.
                                                                                                           bioclMBlcal «Mects la lii«r   5
                                                                                                           r«cor«T*d froa depression.  '
                                                                                                                                                Baasea. l.B.
                                                                                                                                                Tboasea, I.s.
                                                                                                                                                Testergard. P.
                                                                                                                                                larsea.
  5139
  Blood.
            ec
                                                IOBBSH
                                               or cisss
                                               10
C21-B29-B3-0
«I 339.»7, HC
                 :: ^SfflSs-cTO.^.^-.^^
ni«B ' 	
	 • 	 	
50-300 aaol/1
"mi ~—
•ot gi*«B
                                                                      (9 CI)
                                                                                    26.6
                                                                              c»«t nair
                                                                                                          !"« •"> »«. M/«aT.  3-6 .k
                                                                                                          S*«a4i-atat«s
                                                                                                          Istlaatsi (to. qr*pi»


                                                                                                                     ** *itt
                                                                                                                     B«aiark
                                                                                                               ™:,         88 o
                                                                                                           ?: u  ?stlpttl<>B' »a»««a.
                                                                                                          tloch«.ic.l «tf«ct» i» lll
                                                                                                          r«co».r.i  fret d.pr.sslo"
                                                                                                                                  BISOBBEBS-
                                                                                                                               Baasaa, l.B.
                                                                                                                               Thoisen. I.s.
                                                                                                                               Testergard, p.
                                                                                                                               larsen.

                                                                                                          C«atli  fro.

                                                                                                          *« TT  «U f«nle

                                                                                                          Car4iopillan(tT arrest

                                                                                                          «oes; siooD; oBns IBBSE-

                                                                                                          '
                                                                                                                                     ,  ..
                                                                                                                              Stafford, tt.T.
                                                                                                                              tell. j.s.
                                                                                                                              19SO
                                                                                                                              Joarnal of Forensic
                                                                                                                              Sciences 25(11:33.39
-------
2-PyrldlMacetaaite.
2-Pyriilaeacetanide,
1737-09-5
C21-H29-B3-0
BB 339.»7. IF 9*.5-95.0 C
                                                                          -  c. ex,

IXSSBB
51*1
Blood.



Blood.
elassa




51*3
Blood.
seraa







BIMSDB3 BOBIZ
--
Xagestion



lagestioa




•
lalection







AULTTXCiL
BETBOB
BM.C



me




ec





-

BOBBEB
OF C1SBS
a) 5
bt 6



6




9








a) *.5-S.» sg/al
b) 5.0-7.1 ag/nl



3-0.2 v«/nl




at 2.6*-1.85 ng/al
b) 1.71-1. »0 «g/al
c| 0.66-9.«0 og/al
dl 1.9-0.1 «g/sl







1 BEIB
a) *.9 • or - 0.6
b) 5.9 * or - 0.2
«g/sl


Bot given




a) Bat applicable
B) lot applicable
e) Bot applicable
1) Bot applicable







. _
t) 200 ng « i/Jay aainteaance dose
Byocardlal iafarctloa patients, ages
««-73 yr. «t 62-90 kg.
Bpocs; inmiiii: RSIBT DXSEISBS:
BICOD nisii: sine TBSBIPT; iftttiis
2 and 58 ir after 200 sg dose as
Tbospaate. Initial aeasareneat. 1.8
ag/nl at 0,5 ar
Baage of seals, estiaated froa grapb
Fatients vltb renal Insaffleleacy
regnirlng loig-tera aenodlalysis
ItlllTS: BBMT PKB»SIS; IIBBR
EISM5M: HniBBBTtmic IGIITS: OBVG
ICEBIPT
a) 150 sg dcse. followed by 8 «r If
b| 75 sg dose, folloned by 8 or If of
cj 25?sg dose, followed by 8 »r If of
2.5 aq/hr
d) 2 and 30 fcr after 2 ag/kg bolus
IT, 8 sab-teets. Bstisated fron graph
at -e) 0.5 and B br after start of
dcse, 1 snblect.
Borsal volunteers
BBitw KiBeec"; IDBHSJ BLOOS SIBBB:
iBTiisaananc iciBts; DXTOS

ttnazfcs

Ilett. I.F.
Badsen, B.B.
foods. J.D.
1979
Clinical Pbanaeology
and Tberapeatics

.
Sevka, B.J.
Ratthews. S.J.
Blghtiagale. C.H.
Izard. B.f.
Fiellsan. 1.
cho«, a.s.s.
1981
Clinical Fbarnacology
aad Therapeutics
29(3):322-326
	
Lawrence. J.H.
Brysoa, S.B.
Snsner. D.J.
1979
Biopharnaceatics and
Drag Disposition
1:51-57

















•-J
N)







137-5B-6
              68-69 C.  BP 180-181  C at  » an Bg,  159-160 C at 2 an Bg

TISSVK
S14»
Blood,
plasaa


BXPaSBBS BOOTB
Injection
Inaestion
(octal


1I1ITTIC1I
arraoo
oc


HlflBtS
OF C1SSS



B1ISB
a) 0.3»0-0.59« ng/1
b) 0.085-0. «60 sg/1
c) 0.2*3-0.829 ng/1
(Ittt

RIB
	
a) 0.«9« + or - 9.09*
ng/1
b) 0.26* * or - 0.11&
c| 0.529 + or - 0.22J
nq/1
ntsi)


at «0 aln Tf
11 oral lone (capsale)
c) Kectal dene (agaeoas solatioal
0-8 kr average levels conpated fton
aiea-«nler-tbe-cnrre/«90 nla. 5os«,
200 aq If, 300 ag oral or rectal.
lealtar 23 to 26 »r olds. «t 65-85
kg, fasted before dose.
vsoesj ^BT»»Bla»DS: 81003 fi»S"»;
CC>m»iTTf» lfHO»TIO!IS; iBWlTS;
ftOCO

BEFB9BHCE

de Boer. *.G-
freiner. D.9.
Battle. H.
Prosit, 3-
Gabbens-Stibbe, J.R.
1979
Cliaical Pharaacology
aad Therapaatics
2«t*):701-709

-------
fI;f.'"fr*°JT^U**' *-Mi«t»rl««l.o)- (8 CD
m-sJT* 2-'dl«t^1"1"»-«-».«-«l"t»riS«rii- (9 CD
CU-B22-B2-0
•• 23«.33. BP 68-69 C. BP 180-181 c .t •  .. B,. 159-160 C at 2 .. Bg
T1SSBB
51*5
Blood,
Flana
-
Blood,
•hole

B&PQSOU 1OOH
iBjeetloB
iBJeCtlOB
Ingest ion
lectal

IBURICil
BZTBOB
as
ec

ttriBft
or cms

6

" iiifii ~~
	 	 	 	
1.8-3.2 ag/al
•) 0.30-0.57 Bg/1
b) 0.079-0.35* Bg/1
c) 0.206-0.60 ag/1

! BBll
2.5 ag/sl
a) 0.398 » or - 0.098
Bg/1
b) O.m » or - 0.102
Bg/1
c) 0.377 » or - 0.1*2
ag/1

GJItUl IBFOIBITIOB
— 	 • 	 _
§2 'I0?*1** *••»• followed hT°12 kr
IT °" 30 Qg/kg/sin. Levels of 2
aetabolites also aeamred.
leaal failure patients OB caroaic
heaoaialrsis. either anephric or «ith
creatiaiae clearances of < 5 al/»in.
Bo congastive heart failure or liver
»c central nervoBS avsten toxic itr or
changes in heart rate or Mood
pressure.
BOTGS: BBTIBOHSB; B10OB PIISB1;
DISBftSBS
a) 60 Bin IT
r) Oral dose (capsule)
c) Beet a 1 dose (aqneovs solution)
9-9 hr average levels coaputed froa
area-nnaer-tbe-c«rve/«SO ain. Dose.
200 Bg If. 300 a
-------
 28-1,2,»-BenzothladialIiie-7-salfOBaaid«.  «-chloro-3,»-dihTdro-2-nethrl-3-(((2,2.2-trlf laoroathrl) thio) Methyl)-, 1.1-diozide
 3»6-18-»
 C11-B13-Cl-F3-l3-0«-S3
 tl  «3*.*0,  He  202.5 C, also  reported  as 207-217 C
tISSOS

$1*8
Blood.
plasia





51*9
Urine





EXMSOBB BOOM

Ingestion






iBgestioB





aUiniClL
(1ST BOD
OC






GC





IDHBE8
OF C1SBS
18






13





MWI

0.61-1.0* ng/ml






11.62-32.5m of dos*





mi

lot applicable






20.3*1 of dose





GEIEMI IBFOBHTIOI

Bange of seans, 1-48 hr after 1 »q.
Peaks at 5 hr in nost patients.
83.5V protein-bound at 10 ng/nl.
Bcnoexponential eliiiaation.

Serial 16-*S rr oils, fasted
etetniqlit before and 2 hr after dose.
BBOGS; DIOPFIICS; BBiSOSEBBHT
RITDODS; B10CD PUSH; UPIHE
0**6 hr cuialatife excretion after 1
• »q-
Xorial 18-45 TT olds, fasted
oierniqht before and 2 hr after dose.
|
DBOSS; DIUSTTICS; flElSHBES!KT
NtTBODS; BLOCD PUS!I1; UBI»! I
FEfEFSJCE

Potts, D.C.
TVOI6T, T.B.
1978
Clinical Pbaraacologr
and Therapeutics
23 (2): 2*1-2*6



Robbs, B.C.
Tvoney. T.B.
1978
Clinical Pharmacology
and Therapeutics
23 (2): 2*1-246


2R-1.*-Beazodiaz«pin-2-one,
2B-1,a-B«nzodiazepii-2-one, 5-{2-chlorophe«fl|-1,3-dibrdro-7-nltro-
U22-61-3
C15-H10-C1-I3-03
II 315.72, IF 236.5-236.5 C
TISSUE

51EO
Blood





5151
Blood,
plasia





EIFOSOIB aottrt

Ingest ioa





Ingestion






aUlYTTCU
BBTHOD
rac
BalioMtry
SC-EC





RadlOMtrr
nc






BOHBIS
or cis is
i





i






niei

12-1.0 ag egnlT/sl





a) 17-6.2 ag eqoif/al
b) 17-1.0 ig egdiT/il






IE1I

lot applicable





a) Rot applicable
b) lot applicable






G!»!B»t IIFOaUIIOR

1 and 96 hr after 2 19 of aicronized
clonaTepai-2-14C, deternined by
GC-ZC. Aqreed vith TIC, cadioiettr
valaes. Biezeooential decline.

DBOGS; IMSOJEBIIT SFTHODSJ BIOOD;
iiTico»Tnts»iras: connaiTife
EfaiuaTiows; BLOOD PUSIA
a) Total 1»C
b) 1*C-clona2epan
1 and 120 br after 2 ag of licxoniled
clonaiepan-2-1*C

BB1SS; 1EIS01ENMT HTT80DS; BIOODj
UTTCOWTBlSalTS: COHP»B»T1T!!
MatViTtOllS; BLOOD PU51J
SZFEIEICE

de SilTa, 3.1.7.
fnglisi, C.T.
HQnno, 1.
197*
Journal of
Pharnacentical Sciences
«3(«): 520-527

de Silva, J.J.F.
Pnqlisl. C.T.
Banco, I.
197»
Journal of
Pharmaceutical Sciences
63(4): 520-527

-------
C t»-Bf 7-C1-I2-0
•I J2».«3, BE t*s-l«« c («l«o
                                      '- CcycJopropvl.,*,,!, -t,3-dl.Taro-S-pa«rl-

                                        t*«-i*7 q
TISSUE
-
5152
BlooJ.
Plasaa
5153
uriw

KIMSntS MBTB
	
Iage*tioa
Inqwtio.

1M1RIC11
BRBOD
«C
«C

imtat
or cists
— 	
5
-
5

flS5 i 	 ~ 	 	 	
I **** 1 SMERal IIFOlaaTIOf
	 f l'
S! £ gJS - B'USI * " - 10° / S rtete
?! s &:.• i .bur • « - » ?,*
3 - #= 22" ' — "• <
BKK i £§••-- jg«
i HI . r " 11 ! s~ ~^«rs'sr.r -
1 f) 179 * or - 33 | prazepaa
1 ng/nl j
1 2U2i5 * ot ' " ! SESV"""*"'- " 56"H *9> "e
1 h) M * oc - 38 «,/.! |
1 1 «1»»IKEPI1M5 OIITSD KH6DO1I:
j 1 IBUlTSi LlfSSj D81IE! HWIBOIISI
8 !:K:S S S t5 : S : ^:S i \\ SKss-^-
j | Betabolltes In 2» hr speciieits »£tec
J 1 30 •« PCazepM, * dose excreted
| 1 rasttnq non-sBoken, vt S6-«» kq. age
1 1 20—%1 yr
| 1
' 1 BMZODttZMHES; DKTSB KIWSDOB:
• 1 IMITS; ITT«; D8IIII; «W1%OIISS


nrnacs
Chasseaod, i.f.
Taylor. 7.
Eroate, E.E.
1980
Jooraal of «tariacr anl
Phanacologj 32:652-653
Chaaseana, L.T.
Taylor. T.
Brolie. E.E.
1990
Joarual at ?karaacy anl
Phanacoloqj 32:652-653

il 2B».7S. at 125-126 C
                                                                                                                                                                                           Ul
1ISSOI
515*
eiooa
S155
Bloe4,
plasu
5156
Blood.
plasia

IIPOSBBE tOUTE
Ingest ion
laqestloi
Tnoestlon

Jllirticu,
•mcB
ec
	 . — 	 	
ac
sc

	 !•• • L 	 _
IVUBSB
or ciszs
5
5
5

B1BGZ
1M-130 .9/11
225-20» »g/al
	
25-22 ag/al
(MIT
isii
lot gi»«»
lot given
lot glTen
PISE)
G'llgll IiroBBlTIOi
	 	
10 «q, 2.5 hr later, 1000 1 heparln
Reaaued before »ad 15 »in after
teparln. corresponilnij free icnq
values. 3.6-6.9 x)/al.
•craal 23-»0 »r olds.
IIPIUS; "BOMIWSi SBT«BOLISB: B1OOD:
31COB PUSH; i»oe I«T8E»CIIOII:
CHD5S; HOSC1I PELAT1TIS
10 aq, 2.5 hr later. 1000 0 heparln.
««a«rel before and 15 aln after
hcvarlft. Corresponding free droo
values, J.S - S.9 aq/al.
Ior.il 23-HO yr oils.
1TPIBS; PROTIMS; SET»B01IS»: BIOOD-
steoo ntsui; BUDS i»TE»icTi6ii-
MUGS; IUSCIE EPUltlHTS
10 aq, -1. 5 hi later 1000 0 heparln.
neasnrel before and 15 .In after
teparin. Cocrespondlnq free 4rnq
values, 0. 42-1. 01 nq/al.
loraal 23-»0 yr olds.
IT?IBS: PPOMIIIS; BWUBOIISB; S1OO3:
BtCOO ?t»S1S: DBOG IHTEMCTIOK;
tS!IGS; IIHSCIB TIIHTiirrS
— 	 _ 	
SlriBUCE
Footledge. p.A.
rltchell. S.B.
IlornssoE, T.B.
Sltloner, 1.
llnnolla, •!.
Shan a, D.G.
1480
Clinical Phar.acology
an! Therapeutics
27(4)!528-532
Tontledge, ».».
Kitchen, B.B.
Blornsson, T.D.
Skinner, T.
linnoila, n.
Shand, B.G.
1980
Clinical Phariacology
and Therapeutics
27(»):52«-532
Toutledge, P.I.
Fitchell. B.B.
Bjornsson, T.P.
Skinner, T.
linnoila, R.
Shanil, D.G.
1930
clinical Pharaacoloar
a»d Therapeutics
21 m: 528-532

-------
2B-1, »-B«B*oaiazepU-2-oaa. 7-chloro-1,3-dihydro- 1-nethyl-5-pheBil-



C16-B13-C1-12-0
HI ZV«. », n
TISSUE
5157
Bleed,
plasaa


















5158
Blood,
plasma








5159
Blood.
plasma









El POSHES BOOTE
In lection


















Ingestiea








Ingestiot









UllTTICja
BBTBCD
OC-EC


















GC








oc









IOBBSS
or CASES
*


















2*








1








(con
iaVSB
at «00-2.5 mg/ml
bl 290-6 ng/al
c) «50-« ag/al
At 520-8 ng/al
e) 3.5-«7 ng/al
f) 3.5-16 ng/al
g) 3.5-36 ag/s.1
h) 7.7-28 ng/al


















a) lot glvea
b| lot given
e) lot gives
d) lot gives








a) lot applicable
b) lot applicable
ct lot applicable







fill!

mi
at lot given
b| let given
c) lot given
d) lot given
e) lot gives
ft let given
gt let given
h) lot given


















at Hi ag/al
b) 97 ng/al
cl 102 ng/ml
d| 76 ag/al








a) 1007 ag/al
b) 1250 ng/al
e| 2*30 ag/al






	
rial)


at Initial eeasanaent and 6 days, 2*
it Initial aeasnreaent and 9 dnys, 69
yt eld male
ct Initial aeasareaent and 7 days, 29
yr old female
d| Initial meaaareaent and 8 days, 62
yr eld female
e| DesaethyldiaTepaa, initial
measurement and 2 days. 7.0 ng/al at
7 days, 2» yr old aale
f| Desmethyldiaiepaa, 0.25 and *
days, "lateaa » 9 days, 69 yr-old
•ale , . .
q) Desmethyldiazepam. initial
measurement and 3 days. 22 ng/ml at
7 days, 29 yr old feaale
h) Desmethyldiazepaa. Initial
measurement and 2 days. 20 ng/al at 8
days, 62 yr old female'
9ose. 5-10 sg. IT
Sacking associated with higher
clearance valaes
Healthy snblects
BSDGS: DltZIPMS; BEIZODIiZEPlSBS;
IGI: six; MCOD Plasm; SSOKIIS:
BF'BBOlISllj HBTaBOHTBS; COSPIBMTVE
EVal9ATIQlV5t aDtfLTS
at Snblects, high nenroticism, 1.5 hr
after dose
tt Controls, 1.5 hr after dose
c) sabjeets, high nearoticisn, 6.0 hr
after dose
d) controls, 6.0 hr after dose
s mg dose. Controls differed
significantly at 1.5 hr.
Healthy 19-21 yr old Japanese, no
ether drags, evaluated for
nenroticisa, dosed after aeal.
rmres; as»zotnti?ii!s; sBDMtyss;
HOOD P11SH1; 1DOLTS; I30BOXOGIC
Hlf TF^STITIOV5; CO^PIS&TITZ
IllLUflOFS; J»P"
a) nay 1 of 7 days on placebo
b) Day 1 on 10 ng ilazepaa
«1 9ay 1* OB 10 a? diazepan
tata also for H-desaethyldiaiepaa
• 1 yr old dlazepaa abnser.
Iisalraent of eye-hand coordination.
performance la tasks requiring
sustained areasal. information
ctecesslng, and short tern e«sory.
MUGS! StCOO Slim; HBMB01ITES; DUDS
lt«S«; BHMfitS

BtrUBEBCE

Greeablatt, D.J.
Ulen, B.D.
Baraatz, J.S.
Skadar, B.I.
1980
Clinical Pharmacology
and Therapeutics
27f3ls301-312


















Vakano, S.
Ogawa, 1.
Kavazn, Y.
1990
Clinical Pharmacology
and Therapeutics
27 (3) : 370-37*







	 	 	 — , —
tinnoila, H.
Ervin, C. ».
Erendle, 1.
Skinner, T.
Bovtledge, P.I.
1980
Icta Pharaacologica et
Toticologica *7:75-77






-------
C16-H13-C1-I2-0
•I 28*. 7«, BF 125-12C C
TISSBE
— 	
5169
Blood,
plaasa





5161
Blood.
Flasna




SK2
Hood,
Plasaa








51«3
Blood,
sems














	
EXMSOtS tOOIB

Injection





Injection




iBaestioB








IB -lection














— 	
AfaLTTlCAL '"""
•RHOD
ac





GC



--
CC-BC








SC
















or CASSS
i





23



.
a> 12
b) 14








7















H-U«TJ.» yea)

B) 240-12.5 ng/al
b) 1750-28 ng/al





0.09-2.73 ug/Bl




a) 1*0-12.5 ng/nl
b) CO-IS ng/nl








a) 350-2*5 ng/nl
b) 400-325 ng/nl
c) 410-3*0 ng/nl
dj 105-100 ng/nl















•Ell
a> lot aivei
b» lot given





0.96 uq/al




a) lot applicable
b) tot applicable








a) lot given
b) lot given
e) Rot qlvea
d) lot given















(•EXT PAG1)
SEIEE1L IfFOBRATIOV
a) Initial icasarenent and 72 hr
b) Initial seasurenent and 9« hr.
pro treated «ith C.O aq cisetldlne
Istlnated fron graph
Dese. 0.1 nq/kq.
Bealthy volunteer, fasted before
dose.
Sedation when pretreated nits
cinetidine.
BMJSS; DBTJC inrSACIIOR;
Tp.AiQon.itns; eissiHT; BIOOS PLASHA:
SIEATITSS
level required for sedation. Dose,
3-70 acj IT. Dose- and
level-correlated r>0.84«, p<0.001.
»»•- and dose-related, r— 0.«S.
f U.wDl.
Cardiac patients »lth arrhythnUs
treated by elective cardioversion.
C906S; BKW5 THSBIPY; SEDATITBS; BLOOD
ELASflA; AGV; 88 AST DISUSES
-
a) Controls. Peak at 2 hr
t| Alcoholics. Peak at 2 hr
•eans. 2-«8 hr after 10 ig. Peaks
differed. P<0.01. 3.5-hr values
differed, P 5 yr.
On hypnotics and neuroleptic draqs.
DiaCS ; D«B6 THIFA?!: AljCOHOLIC
B1VEBA6ES; FIILAID; BLOOD PIAS«A:
CCSPARATIfS JVAIOATI01S; ADDWS;
vflSCLE REIAIMTS
a| Reans at 4 and 8 hr. aineral
•ater given at 5 hr
tl (leans at 6 and 8 hr. Initial
icasurenent, 380 nq/nl at » hr.
Carbohydrate neal at 5 hr
cl deans at C and 8 hr. Initial
•easnrenent. 390 ng/nl it « hr.
Tatty neal at 5 hr. i)
l-aessethyldlazepan neans at * and 8
•r. Initial neasurenent, 10* ng/nl
at « hr. patty neal at 5 hr
tstlaated fron graph. Dose, 0.3
•9/kq diazepaa. IT.
Bealthy volunteers, neaa aqe 21.4 *
or - 1.7 yr, no previous diazepan
eee, Finland.
latique after fool 6 hr after dose.
Ability to dlscrialnate flickering
light not correlated •ith sernn
levels.
caass: ?IKLI»; BUSCLI RELAXAOTS-
S10CD SB81B; CO'CHATTY* EVAlnitIO»S-
»1TABO'.IS?I; IOTTOLOSIC 1AIIPISTATIOHS

IEPEEERCE
Klotz, 0.
Beinaan, I.
1980
Rev England Journal of
Bedicine
302(18): 1012-1014



tiaidenberg, a. B.
Levy, H.
varner, H.
Continho, C.B.
Sckvirtt, R.A.
In. s.
Cheripko. J.
1978
Clinical Pkarnacology
anl Therapeutics
23(«):371-37«
Sellnan. B.
PeMarlnen, A.
Kangas, L.
Raijola. E.
1975
Aeta Pharaacologica et
Toricologica 36:25-32






tinnoila. 1.
rorttila. r.
Rattila. R.J.
1975
Acta Ptiarucologica et
Toricologica 3*:181-18«















-------
2B-1.«-B.«odi.T.pi.-2-on,. 7-c.loro-1 ,3-di.ydro-1-.ethrl-5-,*e.rl-

«29-1»-5
C16-B13-C1-B2-0
11 2e«.7«. BI
1ISSOB
51«»
Blood,
Ser«

125-126 C
EirosvBB looiz
	
Injection

iHLiticii.
BETHOD
oc-ec

IOBBM
or cisss
2S

(coBTi
" iiiG!
•) 750-35 •«/•!
b) 600-55 ng/al
e) 25-«0 ng/nl
4) 3O-60 ng/ml

IDE91
BMB
	 	
a) Hot giv«ft
b) Bot 9-i«n
c) lot gi»en
d) Bot gi»«n

	 GEBEBll IBFOBHaTIOH
a) Initial neasnreneat and 72 ht
after 0.2 nq/kq. « Canscasians
tl Initial measurement anfl 72 hr
after 0.2 nq/k
-------
6M-7S-1
C15-I11-C1-H-02
•I 286.71. |( 205-206 C
                   .B-2-OM. T-CBloro-l,3-dihrir«-3-«7«rorr-S-p»e«rl-
1135(1
5167
Blood.
Flasaa
51CS
Brine

Bifosnts toots
Ingastioa
laqeatioa

IMtnmi
RRBOB
6C-EC
6C/BS

ImiBSH
or cisss
...
a) It
b| 20
3

BAKB
	 	 	
») «27-1«17 ng/Bl
•) lot given
b) lot given
c) lot given
A) lot given

BE1I
a) «22 « or - 37
Bg/Bl
b| 837 « or - 51
Bg/nl
SE
a) 5. 2 * or - 0.5*
(520 * or - 50 tig)
b) M.7 + or - 9.0*
(»170 » or - 900 agi
c) 7.7 » or - 0.5«
(770 » or - 50 ng)
4) 67.3 * or - 1.7*
(6730 » or - 170 og|

GEXISAt XlfOKBiTIOl
a) Bei
b) Voaea
leaks. 2-3 hr after 30 aq, single
dosd
Peaks negatlvelT correlated «ith body
• t »r - -0.«3. P < .01). Higher
clearance also associated vith heavy
clqarette snoUnq.
lenlthr 22-«« yr olds fasted
oveniqht and 3 hr after dose. B».
aiSSACBBSMTS; *BBHS: AGE; SET;
ELCOD PllSBl; DCDCS; SEBA1IVES:
IfAlOATIOBS: SBOKIIS
a) Unchanged drag, 0-8 hr
t) Conjugate. 0-8 hr
c) Onchanged drag, 0-24 hr
S) Con1«gate, 0-2» hr
Dose. 10 nq
JIPll; BIOOB PllSPU; OBIIE; DRBGS;
	 — 	 — 	 	 	
BEfEBElTCE
Greeablatt, D.J.
Bivoll, 9.
Rarafttz. J.S.
Shaier, B.I.
1980
Journal of Pharnacologv
and Szperineatal
Therapeutics
215(11:86-91
Biqnchi. S.
nrabe, g.
shlobara. T.
1979
Jonraal of
Chronatographr
16 «: 55-61

                                     ' ,3-ai»Tdto-5-phe.rl-
C15-B11-C1-1J-0
1«  270.73
-P-
•vj
vd
HSSOS 	

5169
Mood
S170
Blood

cirosoB*. ionii

tigestlon
laoestlon

iiiLnicu.
RTBOD
ec
	 . — . 	 -


niBEt
OT CISZS
S
-
1



15-H U9/«1
— — , 	
•ot give*
(KIT

HB1I
lot glYeu
0.7« ng/al
PtSS)

SilCUL IIFOSfllTXOI ~
10 wj. 2.5 hr later 1000 B heparla.
fcasurei before and 15 Bin after
aenarln. Cocrespooding free 4ruq
values, 0.62-1.01 aq/nl.
Iccaal 23-«0 yr olds.
IIPIBS; p»oiti»S: SEnioiisa: BWOD:
StCOD Pl»S«»: 9»BG IKTSFlCTIOJ;
HISS: aoscii BEL»S»IITS
	 -
ivtopsr saeple
«< jf old pharmacist, suicide.
cverdose of other dcaqs
BSBSS; 9B!JG 18HSI; SUICIDE:
itnopsits; CISF Bisiowfs;
llSSOSSHIilt METHODS; |EW ZE»1»1ID'
"5"' 11T'*! »P1IIS! itmaETsj BBHM:
SL CO BOL5


IEFEIERCE
-
Soatledge. p. A.
rttehell, B.3.
Bjocnason, T.O.
Skinner, T.
Hanoi la, n.
Shand, D.G.
1980
Clinical Pharnacologr
and Therapeutics
2T(»): 528-5 32
Oaeree, E.I.
Clckson, S.J.
(lissen, ».».
Pannell, 1, it.
1979
Journal of Inalftical
Toiicaloqj 3:253-255

-------
2B-1.a-Be»«>«iaz«pli>-2-one. 7-ehloto-l .S-dihTaro-S-phenjl-
lflM-11-5
C15-B11-C1-I2-0
11 270.73
TISSUE
5171
Blood,
5172
Blood,
nlasM
.
•173
Blood.
plasna
	

BIFOStllE ROBTI
	
Inoestlon
Invest Ion
Ingest ion


ISAI.TTICAL
BETHOD
GC
8C-BC
«C-BC


BOBJM
OF CASES
"
1
8
"
12

(CORJ
JAKE
	
a) lot applicable
b) lot applicable
e) lot applicable
— 	 "
759-37«8 ttg/1
72-16S ng/nl

BUEDI
	
a) UOO ng/al
b) 990 ng/nl
c) 3110 ng/nl
.
Bot gi»en
138 »or- 8.8 ng/nl
SE

	 GEBIBA1 IBFOBHATI01
_ 	 	 	 	 	 ' 	 ~
a) DnT 1 of 7 days on placebo
b) Day 1 OB 10 ng diaiepaa
e) Bay 1« OB 10 ag diazepaa
M yr old diazepaa abnser
lapairaent of efe-haBd cooraination .
cerfornance in tasks requiring
sustained arousal, infornation
processing, and short tern nenory.
EB06S: BLOOD SMBU; BOTABOLITES: DUOS
IBOSE: 9IAZMMS
Rean steady state values after
1.0-3.1 nq/kq.
lEllepsy patients
BICBTS11; HBBfOOS SYSTEM BISZASBS!
nooo: BIOOB PLASM: IBTICO»WLS»BTS!
CBBB THESMTs BKOSSi TaMOKW««»S
IB tI»«O »«1IISIS: SEASOBEBEBT
BITHOBSi BMtOSIAtSSHBS
Peaks, at 2.S-72 hr (nean 13.1 hrj
after 20 ng irazeoan.
Eealthr 22-«2 Tr olds, »t S6.8-88.*
kg. Tasted before and after dose.
SB1SS: DIAZIFAHS: BEBZOBIASIPISIS;
USE- SBf! SICItJIS: BIOOD PL»S»AS
BITABOLISB: CO1?ABATI« STAtBATJOBS

1 SETBRBirCB
	 	 	 < 	
linnolla, B.
Ervin, C.B.
Brenlle. A.
Skinner, T.
Foutledge, S.A.
1980
Acta fharaacologica et
Toiticologica HI: 75-77
Paidnke«7ch, D.
Bodin, B.A.
DaTeaport, F.
1980
Clinical Chenistry
Allen. H.D.
Greeablatt, D.J.
Haraatz, J.S.
Shader, B.I.
1979
Journal of Clinical
Pfcaraacology 19!«as-a50





00
0

                    ;: ?3L«S=ffiMZ'^^
  -.
C15-BIO-C12-B2-02
81 321.1«« Hf
IISSDE
517«
Blood.
plnsna







166-16* c
HIFOSMB BODII
IB-tectiOB
Ing«*tion








aiURicii
RETROD
8C-BC








BOHflSl
or CASES
10








— 	 BABSE^
n) 17.6-60.7 ng/nl
b) 18.0-36.4 LJ/al






	 • 	 " IBBIT

— BEAB
al 38.»2 » or - 13.25
ng/nl , „
b) 28.85 * or - 6.13
ng/nl






US I)
	 	 	 • 	
	 —
a) Peaks, elderly. Peak tine, 0.9" »
cr - 0.19 tst) nr after 1.95 » or -
0.83(SD) ng orally, 10 subjects
M Peaks, elderly- Peak tine. 1.03 »
or - 0.16ISI) «r after 1.85 • or -
0.7a(S01 nq IB, 10 sublects
Seae data for TT doses.
Bcalthy 60-8« tr alas, vt W.s-111.«
Crovsiness. sedntion. sleep for 1 to
6 fcr.
tBOSS: 111IIOtIA''WItBS: A6t: BtOOB
I1AS1A: 1«Ilti SBOKItS; COISABAtlfB
ItAllATIOBS

Wrssnct

Greenblatt, tt. J.
»11«B, B. 9.
locslskar. A.
flaraatz, J- S.
Staler, P.I.
1979
Clinical Pharaacology
and Therapeutics
2e(1)s103-113




1 	 	 . 	

-------
C1S-B10-C12-12-02
•t 121.i«. n 166-168 c
TISSUE
5175
Blood.
Plan*
5174
Win
5177
nrlae

nmssn torn
lageatioa
iB-Jectioa
lageatioa

auinioii
HFfBOD
QC/IS
«C-IC
ec/is

OF CUES
3
9
3

BIB6I
a) 28-6 i,/.i
b) 18-1 ag/al
*) lot give*
b) Bot given
e) Bot gl*«
	 _ 	
a) Bot given
b) Bot given
e) Bot give*
d) Bot given

BSaB
a) Bot given
b| Bot given
a) 835 of dose
b) 80*1 of done
c) 67V of doae
a) 0.10 « or - 0.02*
«1-5 » or - 0.3 ng)
bj 26.1 * or - 3.6T
(391.5 » or - SO «g|
e| 0.59 * or - 0.2*t
(8.85 » or - 3.6 «g|
dj 68.3 .or - 5.2*
(1024.5 * or - 78 eg)

CEBEMt momTIOB
".•'i!*? of ****** anchanged drug. 2
and 2* hr after 1.5 aa. Initial
BCBBweaeBt. 2» Bq/al at 1.5 hr
*'*"*? °f aean«, conjagated drug, 3
!««£ ht :fttf 1>S '«• I»itial
acainreaeot. u »g/«i «t 1 hr
tatinated fien graph.
«P1»: BtOOt FL19U; 01IBE: tSOGS;
inllQUttltCTS ; HE1SOB? BEHT HETEODS
a| IT
II Oral
c| In
72 br emulative excretioa of
glncacoBlde in elderly vol.nteers.
lecoasted for 80-90* of totnl
clearance.
Browaineas. sedation, sl^p tm , to
«B8S: BinOBIKEPIBBS: iSE; BLOOD
* DBI VE$ SHOK3V5 : COHPIBITTTE
a| Onchaaged drag. 0-6 hr
>) Con1«g>te. 0-8 hr
cj OBchanaed drag. 0-2« hr
«) Conlvgate, 0-2a hr
Ccae. 1.5 eg
IBIVQUmms; BEtSOTESEBr'aWFODS

BETSRBBCB
Rigachl. s.
Orabe. B.
Shiobara. T.
Journal of
Chroaatographr
16»: 55-61
-
Greenblatt, B.J.
Allea. B.D.
Locniskar. 1.
Haraatz, j.s.
Shador. E.I.
1979
Clinical PhireacolooT
and Therapeatlcs
26 (IJs 103- 113
fligachl. S.
Qrabe, E.
Shiobara, t.
1979
Journal of
Chronatographr

                                                                                                                                                                                         00
 CS3-B31-I-O2
 M  353. •».  Bt  193-217 C
                                                                                         „
    iissm
5178
Blood,
flaaaa
              BHOSms 10011
               laqestlon
                                    BITHOD
 rants
or cisss
                                                                          BIBGB
                                                                a) 0.023-0.118 ««/•!
                                                                b) 0.055-0.193 ao/al
                                                                c| O.OST-0.123 nj/al
                                        at 0.060 og/ml
                                        b) 0.1ia »,/,!
                                        e) 0.069 ng/al
                                                                                                                                     I»FOBH»TIO»
•» »J«tTlaet«adol.   Peak at * hr.
0-a«d »»-hr. none detected
II lorieetTlaetaatol.   »ealc at a-8
hr.  Oatectatl. «t 0 aad »8 hr
cl BUoracetTlaethadol.  Pl.teau at
hr.  Only sliqht teclUe at «8 hr
B«»a males .fter «o-«» «,. 72 hr
after preTlcm doae.
                                                                                                                    »4
-------
3-BeptanOD«,
C2'HB27-1-0
81 309. »9

TISSUE
5179



5180
Mood,









5181
Blood,
seres











5182
liver





BIPOSOBS SOOtE
legation



Ingest Ion









Ingest Ion












Xagestion





1I1LTTIC1L
BSTHOD




GC









BIl


















•MBSE
or CISES
1



a) 6
b) <









a












1





««ISB
lot given



a) 138-220 ng/sl
b) 311-580 ng/nl









32-7.3 ««/•! Oeoeatrlc
•cans












lot given



(HIT


0.36 ng/nl



a) 182 ng/al
b) "20 ng/*l









lot given












19 ng/g



MSEJ


aatopsy sample
II yr old pharmacist, suicide
EBOG5: BBIJG IE9SI; SUICIDE;
10TOPSTSS: CIS! HISTOSIES;
qiaSTBMMT BETHODS; »E» ZT1UID;
BtOOD; U»W! UP HI; KIDIEIS; BRall;
I1COBOLS
a) lean daily levels vith maintenance
dcse of »0 tg/day. Level before
dose, 116 nq/nl
t) Rean daily levels »ith inintenanoe
dcse of 80 »g/d»y. level before
dose. 2(5 ng/»l
qenoexponential decay.
20-37 yr olds, fron Tt State Drug
abuse control coulssion. Oa«d
heroin S-22 yr b«t, no druqs for 2-8
•onths.
fo Increased niosla.
BM6S; BIOOB PLiSMj TJSIIE: ISCES:
tt» TOSI; C05PiR»TITE ETaLOKIOSS:
asiiBoiisiij srriBOiiTss
2 hr an! «8 hr after 15.2 » or - 1
• g/kg/1.79 sq * body surface area.
Initial neasnrecent, 28 ng/*l at 1 hr
Estimated frcn graph.
Healthy, nonpregnaat 21-29 T' oUs,
In folllcalat phase of secstmal
cycle, on.
Hethadone-indnced respiratory
devres«lon and nlosis lasted > IS hr.
Staadv state ventilatory response
carve for CC2 inhalation «as
Usplaeed, and papillary constriction
Increased.
COZGOl; atttlTS: BIOOB rZEOS;
IttlSSSTCS; CBOSS; BOB ROUES:
ii?eoTicS) ii TITO tiiirsis;
1* yr old pharcaclst, suicide
DBOGS : DRUS UUSE: saiciDi;
IOTOPSHS; CiS^ HISIOBI5S:
BtOCB! tTVS?: DBHJ: «B«ETSS Bsil*:
iiccnoi-s

" 	 BEFEBeBCE

Oaeree, E.I.
Dickson. s.J.
Rissen. 1.*.
Pannell. l.K-
1979
Journal of analytical
Toxicology 3:253-255


verebely, K.
Tolavka, J.
Rale. s.
Besnick, B.
1975
Clinical Sharsacology
and therapeutics
18(21:180-190








olsen, G.D.
vilson, J.:.
Robertson. G.E.
Clinical Pharnacology
and Therapeutics
29 (3): 373-3 60










Queree, S.a.
Dickson, S.J.
Pannell, L.K.
Joarcal of analytical
Toxicology 3:253-255



                                                                                                                                                                                            CX>
                                                                                                                                                                                            NJ
-------
c:i-§27-i-o
Bi JM.tf
TISSUE
-
5183
Or ice


izfvsnn SODTE
T rtlon



lIUTTXCal
HBTBOD




nriBn
OF C1SKS

C


~~ iiiei "
	 	 	 —
a) 13.2-25.3 X of doee
b) 28. 9- 60. « X of dose

                                                                                     (COITIIOID)
                                                                                           B)  19.16* Of dOM
                                                                                           b)  «1.M  of  dose
CH-B20-I2-02
M 308.37, IF 105 C
                                                                                                                               PIH«L
                    •1 tfter single «0 or 80 no dose.
                    3" erereted as pTrrolidine
                    *) Chronic •tlateuaca dose o» »o or
                    8« •g/J»T.  ««f ercretoj as
                                                                                                                    2«-hr seines.

                                                                                                                    20-37 Tr olds, from It State Drug
                                                                                                                    1!>VM coatrol Coamisaloa.  Use!

                                                                                                                                                 for 2'8
                                                                                                                    >o increased iloits.
                    "ires-. BICOD
                    "  «>««
                                                                                                                                BRiBOtltBS
                                                                                                                                         DS«E: IECIS-
                                                                                                                                          IT.LHllaiS
                                                                                                                                                                    BEPEfiEITCE
                                              K.
                                    TolaTka.  j.
                                    Hale,  s.
                                    Penick,  B.
                                    1975
                                    Clinical  Phutacologr
                                    and tberapeatlcs
TISSUE
518*
Blood.
plnsna

BXPOSmg tOBTE1
Ingeation

aiunicu.
IETBCO
ec

BOBBEB
OF CaSES
<
1
1

~~ iliei
a) 12.48-17.05 ag/il
*) 30.77-«(.33 ag/nl
c) 51.18-88.11 ag/nl

UtB
--
»» ;»•« «,/.!
b) 38. ai ag/nl
c) 75.20 ag/nl

6BIEBAI IIPOBMiTIOR " """""
a) Ifter 100 M
t) after 300 nq
c) Ifter fOO nq
Peak lorels
Bealthr 23-29 vr olds. Trance
^***CE: 1DOLTS; BLOOD PLaStta;

FEFSSE9C2
Sioofi. ».
Colossi, D.
Caudal, T.
Schoeller. J.r.
Hasslas, P.
1980
Journal of
Pharmaceutical Sciences

                                                                                                                                                                                         00
 58-25-3
 C16-B1*-C1-I3-0
 !I  299.75,  BP 23C-236.S C
                          .e-
TISS1!
-
S18S
Clool.
Flasia
MPOSUEE 100TC
lalection

IMITTICU
BfTBOC
-
BPIC

HgSBB
OF CISBS
5

                                                                 a)  C500-200 no/«l
                                                                 b)  6800-180 n-j/al
                                                                 c)  0-1000 ng/al
                                                                 d)  0-2000 ng/nl
lot given
Hot given
Rot given
lot given
                                                                                      (fEIt pact)
 » A  J "•»».  1  "« 30 hr after
«.n.
1980
Enropaan Journal of
Clinical PtarnacolwiT
18:275-278
-------
                                                   banrl-. «-oxid« IB CI)
                                                        .-. *-oxid« |9 CI)
St-25-3
It 2OT.75. 1*
113301
s«6
Blool.
pla«M
5187
Bleoa,
ser»

234-23*. 5 C
HMSntS BOMB
IB Action
Inlectlon
I notation

kMlTTICkl
HETHOD
Ha


imsn
OF C1SSS
•I 11
H 11
c)7
a

(COIM
•" ilies
•} 3.6-0.03 »g/»l
b) J.6-0.16 ««/»l
e) 2.0-0.2 o«/»l
— 	 '
at 1.0T-1.TT «g/»l
b) 1.00-1. SO »g/«l
c) 0.2»-0.8« «9/«l
d) 0.20-1.15 ag/»l

•USD)
SB»1
a) »ot applicable
b) lot applicable c)
lot applicable
a) 1.32 «g/«l
b) 1.»2 ng/al
c) 0.56 «g/«l
d) 0.«« ug/al

	 — 	 SIStHL IITOBIMIOI
	 ^ 	 ~ 	
•1 Hen
c! •«••£ on oral contr«ceptlT«s
!«.,« of «a««. iBiti.l .e.s«r«»ent
ail 56 hr after 0.6 iq/kf. IT.
Il«rpoii««tial elUlnation.
17-39 rr old »n. 21-«2 yr «W «ro»«B-
J«-29 it oW «o««o. o« or»l
contraceptive > 6 •«
111 norial.
BHZOtliZroHIS; DS06S; OBll
ecm»c5wt«si irnnts: s«i: BIOOD
Misa.rww»»"*« w*"*"0"8'
§M»EOHSB: miHK
a) 1 hr aft«c oral lose
il 2 br after oral dose
c) 1 br after I" io»e
i) 2 br after III flose
Do«e. 2? aq a« hTar««"oria«-
CealtbT «en, t»stln:«28-831
Gottschalk. 1- I-
Biener. 3-
DinoTO, B.C.
research Coiaanicationa
in Cbepieal Pathology
anl fhaciacologr
8(1) :697-702

                                                                                                                                                                                           oo

 2S232-5»-8
 C7-B10-I2-02-S
Kf 186.23, «

fissni
5188
Hood.
•ecu
S1OT
•ilk

E 122-125 C

"EHOSOH ioo«
Ingestlon
_
tB^estio*
_ — . —


immcu.
9, J.
Alexander, V.D.
1979
lancet 2(8150): 1011

-------
SSSSSSfc
JC«e«-S6-2
«S«-H27-Cl-f5-«-0
II 523-99, W 105-107 C
                                                te
^

| lISSQt
1
1 	
I 5190
I 11004,
| DlUia
s
1
1
1
1
1
1
1

EIPOSOH IOWE
Tmqestioa
1
«

tmnicai.
nSTBOB
	 	 	
SC-BC
I
I
i 	 __

•nun
or cisss
•I 7
W e
c) 8
I
I
I


EIIGI
«) 3.75-9 «9/»l
b) 6.25-12 »g/*l
cj 8.75-25 »$/•!
1
1
1
1
1
1
1


BED
al 6.25 »g/»l
b) 9.2 ng/ml
c) 18.75 ng/»l
1
1
1
1
I 	



at 30 «q weekly
b) SO iq »««1ilT
c) 120 «q »e€*lT
•tealT state leTela. «sti»ated £ro»
cr&ph. te»«ls corr«latefl «ith Sose.
r-0.81. ?<0.05.
Bcspitaltiea 27-59 Tr oli
sckiiophcenics in qooi phT«ic»l
1 k *«»*s. 13-15 hr after 250-aq
3 o:"o 5/S i «b^». »-« kr •«« *~ "°-ti
S oil! 3/S • ^5- 2™ hc a£t" fo"r 250"9
! «fcpea*s, 12-28 «r after «ll tablets
1 e) teatv 8-12 hr after 500 wi in
i | aqaeovs suspension.
i
I tolnnteers, 21-»5 yr old. dosed 2-3
1 ht after llqold, 360-calorle
I tteakfast.
| CSBSS; liTTBIOTICS; »B01TS; BLOOD;
I USISICT Of COMBBII; COHP»SITIT!
1 IW1WITI01IS: I»*ECT1O*
1 	 __ 	


Cesjardins, B. E.
Eaaplin. C.L.
»o« 3re4o«, 3.
Sarry, K.G.
Canfleld, C.J.
1979
clinical Pharaacology
and therapeutics
26{3):372-379
, . ., i 	 1 	
                                                                                                                          CX3
-------
  ,-Thi.-1-«.cicyclo(3.2.0) h.pt._e-2^.rbo,ylic acid. 3.3-di,.t.,l-6-«C n3-|^l1Tl..lfo.,l|-2-O«-1-i.iaazoUai.rl)<:«bo,Tl)a.l««)Pl.«TlacetTl) .a»o)-7-oxo-.

  <2S-»alpha.5alp_a.6beta(S«)))-
  51*81-65-3
  C21-B25-IS-08-S2
  II  S39.63

1ISSOB

5192
Blood.
plasia









5193
Blood.







519»
nriae







EXtOSOBE 800TI

Injection









' Injection







	
Inaction








1I11YTIC11
BETHOD
Bicrobiological









Microbiological







Microbiological








BOB BIS
OF C1SSS
27









10







10








MIGB

a) <1-253 * or - 129 »g/l
b) <1-20« » or - 81 ng/1
c) <1-252 * or - 75.4
•g/1
d) <1-23» t or - 66. a
•g/1








a) lot givci
b) lot given
c) lot given
d) lot given







lot given










a) lot given
b) lot given
c) Bot given
d) lot give*









a) 30*.* * or - 56.2
•g/1
b) 78.3 * or - .7.1
•g/i
c) 7.2 * or - 2.5
•q/1
d) 0.22 * or - 0.17
WJ/1





53.9 * or - 8. SOU of
dose










a) sableets »ith creatlnine clearance
greater tlan or equal to 60 al/ain
t) Sableets «ith creatinine clearance
30-59 ml/ail)
c) Snbleets *ith ereatlnine clearance
10-29 nl/.in
d) Sttbleets with creatinine clearance
<10 nl/ain
Bange of neans over 24.5 hr
Ifter 30 ain IT of 3 g
•Idolts with varying renal function.
age 32. » » cr - 11.5 to 57.7 + or -
21.5 yr, Indiana.
immil; aTHlITS; KIOIBT DISUSES;
BICOB SUSHI; HTiBioTics: DBOGS:
CC"!?»H»TITE iTAin.IIOWS
a) 0 hr
b) 1 hr
c) 4 hr
d) 1C hr
Ifter 33 Bin IT of »000 »g. Values
adlusted to 70 kg body Height.

Bealthy 20-H9 yr olds, »t 66.9 » or -
£.0 kg.
CIDeS; DUOS IBIE1PY: HTIBIOTICS;
HOOD SSBDS; U8IBB; GJBMST.;
UTK-IOB: CCBP1BITIT! BTitO»TIO»S:
jtnws
1 	 	 	
0-2« hr atcretion after 30 nln IT of
(000 aq.

Bealtby 20-49 yr olds, »t 56.9 * or -
6.0 kg.
BFOGS: nans THISIPT; irpiBiorics:
HOOD 5!Sni: DUIE: 8339111;
IS«I«IO»; CCBP»B»TIT? BTitHlTIO*S:



	 — 	 -
Ironoff, G.B.
Sloan, B.S.
10ft, F.C.
Belson, P.I.
nanell, D.B.
Ilelt, S.i.
1980
Clinical Pharaacology
and Therapeutics
28(») : 523-528






Lode, H.
Toaas, «.
Foeppe, P.
Wagner, J.
1980
chemotherapy 26:81-90







lode, n.
Toaas, V.
Foeppe, P.
eaqner, J.
chemotherapy 26:81-90




                                                                                                                                                                                            oo
,-,hi.-1-.»«CTClo 13.2.0, n.pt.-e-2-c.rboxylic ^id, 3,3-di_^hTl-7-«o-6- «((,(2-oxo- 1-iU..i.lUt.,l| carbonyl. a.im,,pbenylacetyl,a.ino, -.  (2S- (2.1Pha.Salpha, .beta (S«,,, -

37011-«6-0
c;0-B23-IS-0€-S
at ««1.5«
TISSOB

5195
Blood,






BTPOSOBS IOD1E

Tnlection







numcii
RET BOD
licrobiological







IDICBB
07 C1SIS
7







BHGB

260-17 ng/*l







	 BE1B

lot given







CIIEB1L I»rO«»aTIO»

deans, 5 iln and 0 hr after 2.0 g,
I«. Continuous biezponential decline.
•stiaated frcn graph.

22-72 yr old henoiialysis patients,
lost with end-stage renal disease.
Dew Turk.
HOGS: viTnioncs: BIOOD S^PBI:
KIB1IST »TS-«SIS; HEIIOMilTSIS: 1CT
ICHK
BEFEB!I!CE
	
Aletta, J.!!.
•eu, B.C.
1980
Clinical Pharmacology
an] Therapeutics
27 (»): 563-566


	
-------
                 2.0J b.pt...-2-c.EboiTUc
                                                                                                                 o.,l| a.
C2S-B2S-I6-0«-S
HI CTO.C3
BRBOB Ot CaSSS
.1 lot qi*en *) 3*5.0 * or ~ *5-5
•t1*l£ XB^ftCtiOA HlCTODlOlO^iCetl •» *• tjjfc* 4v«*k BQ/1
Blooo. CJ «ot ii,«, b) 102.5 * OE - 21.8
""' «> 10t «1'- c?'lO.« * or - ..3
d) 0.92 » or - 0.50
nq/1
1 , ' '
'
i i
i 	 _ — i 	 • 	
5197 Lotion 1 Slcrobiolooical | 10 1 »ot qlyen 32^ * or - «.3« of
urine I ,
'
1 1
1
I
1
1
1 !
! ._ .
i , ... 	 -' 	

j
;i ? s i --»."•
e> 1 nr ' X0*™*' p-
Ifter JO .in W of WOO «q. Talnes 1 "^"^ ,6.B,-90
ad*1iiste4 to body *t of 70 Kg* i **° "
i
1 sir loos infections caused bj Bay 1
1 «-senslti»e orqanisns. Seraany. 1
1 "
1 Soft stool, aiarraea. nausea, eaesis. I
| headache, vectiqo. exanthe aatoas 1
1 rash, Secreased thronbocytes. 1
1 exhaustion, tachycardia, aeteorisn. 1
I 1
tBOGS; D«US TBBB1»I: »«lBIt«ICS; I
B100D SB3WI: DBIIB; SESSHt: J
IITBCTIOIl! CCBSHatlTI BTaLOWIOTS: 1
	 — 	 ____———— |
0-2« hr excretion in healthy suMects I Lo4e. H.
alter 30 »in IT of »000 nq. K«Bpe P.
I wealthy 20— a9 yr olds, wt 66.9 * or - Waqaer, J«
l-sensiti»e orqanisns. Germany.
Soft stool, diarrhea, nausea, esesls,
headache, Tertiqo, erantheiatous
rash, lecreased throsboeytes.
exhaustion, tachycaraia. neteorisn.
MUSS: DUOS tHIBlPT! HTIBI01ICS:
I1TICTIOI: CC»?»BaTIT! STalOWIOBS;
UOtTS




1
1
1
1
1
1
1
1
1

                                                                                                                                                                                         oo
                                                                                                                                                                                         -j
                                                     6.|nt(^thyl-2.3-dloxo-1-,iSer.xi.yl,carbo,Tl)..i.o,phe.,lac9tyl,a.l,o,-3.3-di«thyl-7-oxo..  (2S- ,2alpha.5alpha. 6beta (S-, „-
6H77-96-1
CS3-B27-15-07-S

Rl 517.«1

IISS5B
5198
Blood,
sernn

SttOSOBE BOUT I
In-Veetion
alalTTlCal
BETHOD
Bicrobioloqical
1
I
BOHEEB
01 CaSSS
b) 6

IUGS
b) 353-22 uq/nl
aim
a> lot given
b) lot qiven

al Beans. 0 and 270 ain after en4 of
30 nln IT of »q/8 hr. day 1. Day »
peaks -lignificantly hiqher
t) leans, 0 and 270 ain after end of
'a nin IT of 6q/6 hr on day 1. Day »
oeak, »10 uq/nl
»9ainister«a as sodiua salt
licalthy 18-50 yr olds, within 10* of
Heal lit
t«1SS: 11TIBIOTICS; B1OOO SEBU1:
	
Catra, T.K.
"orrison, J.X.
lasseter, K.C-
1979
Clinical Pharnacoloqy
and Therapeutics
26(1) -.H1-53
(IEIT *IGI)
-------
«1*77-9«-1
Ci3-B2Vi
If S17.«1
                                               acia.6-,«,(,*-«t,,l-2.3-diox0-1-piP«..i.,l,«:arbo.vl,..i-o,phenyl.c.tn.»i.o,-3.3-di.ethyl-7-oxo-. (2S-«2.1pk..5.1pha.6»>eta ,*.,„-

IISSOI
5W9
OriM


siposraB IOOTI
IB-faction


aliLYTXCU,
RETHCD
Sicrobio logical


IOHBBS
or CISBS
£


cuei
*) 89. 73-80.05* of dose
b) 66.92-8C.9S* of oo«e



a) 76.03 + or - 8.98*
of low
b) 73.02 * or - 7.15*
of dose

Jm, 	 B 	 . — — 	 — 	 —

» Day 1
C-8 hr cumulative excretions at tor 30
•In TV of »g/8 hr
Bcalthy 18-50 jt olds, nithin 10« of
Ideal »t
tSOGS: SHTTBIOTICS; BIOOD SBBOS:
OMR; CO»P»8lTI»B BT113AIIOHS

FZriBEHCZ

Batra, T.K.
Morrison, J.I.
lasseter, K.C.
JOT, v.l.
1979
Clinical Pharaacologi
an! Therapeatics
26(1)s»1-53


26787-79-0
                    (beta-lap»thale»es«lfoii«t« trihvdratej

IISSHE
5200
Blood.
plasma









5201
Blood.
sens






5202
Flood.

5203
Bilk





EUOSHRS BOOH
Ingestion









- -
Injection






iBqestioI

Iaq«*tlon





aiumcu
RB9BCB










. 	 	 	
Sierobiological






licrobioloqical







lOIBSB
OF C1SSS










8






6

6






a) 0.9-0.1 ug/Bl
b) 1.8-0.15 og/al
c) 3-0.1 ug/»l









a) 86-332 ug/il
b) 57.7-19,3 ug/Bl
e] (5.6-14.8 ug/al






7.0-1*. « «9/al

9.10-0.81 og/al






a) lot give*
b) lot given
c) lot givei









a) 1*1 » or - 26
og/sl
b) Not gives
c) Rot given






tot givea

lot gives





..._
a) iBtaet prodrng, sethoij»etliyl
«tt«r. at 0.5 and 1.5 hr. Initial
value. 0.12 ng/Bl. Unspecified dose
if prodraq
I) laoricillin. at 1.2 and 8 hr.
Initial value 0.3 uq/sl. Unspecified
dese of pcodraq
C) laoxieilliD. 1.* and 8 hr.
Initial value, 0.1 nq/al, unspecified
{ese of anoiicillia
lstiaat«d frca qraph.
I1TIBIOT1CS: BL009 P1»S»1:
ccapiviTifi EV»LO»iio»5: BBTIBOIISI;
rces
«) PaaVs. P«ak tine gear 5 ain
b) 30 anl 2*0 (in levels, arterial
serua
C) 30 and 2*0 ain levels, venous
lft«r 1 » »a aaoxicillin IT at start
of 5 he dialysis
17-7* vr olds. »t «3-6B kq. vith
renal insufficiency.
riiics: ttTiBicrics: DISE»S»S; SIOOB
SI501; ID HITS
1 and 2 hr after 1 g. final
icasnrenent. 9.3 nq/al at 3 hr
1>-288


                                                                                                                                                                                           00
                                                                                                                                                                                           00
-------

                                                                                                                          ,  Iboat $ br
                                                                                                                                         nul4
                                                                                                                                                 »«rr
                                                                                                                                                    T
                                                                                                                   CkroBle circhosla patiaata
                                                                                                                              BIOOD SBSOS;
                                                                                                                                   "«"'
a)  Fatleat 1
b)  PatUat 2
c)  Fatlaat 3
                                                                                                                       5 of 150
                                                                                                                                          bT costlwous
                                                                                                                                       * SLOOD SSBn8!
                                                                                                                   a) Cirthotlcs. 542-639 aq IT
                                                                                                                   t) Conttols. .boat 600 a? IT
                                                                                                                   .«,
                                                                                                                   act aaasaall  iapalt«a.  loona.
                                                                                                                                     f.sted
mo^r"1'*"'  '-''-""tbn-.  dichloria,
t12-B1«-.2.2Cl
«1 «08. HP 300 c (teeo.p)
                                                                                                                                                          le.is. s.S.
                                                                                                                                                          Jasko, w. j.
                                                                                                                                                          1975
                                                                                                                                                          Clinical Pharaaeologr
                                                                                                                                                          an! Thetapentics
                                                                                                                                                           lavla, 6. t.
                                                                                                                                                           Juslo. B.j.
                                                                                                                                                           1975
                                                                                                                                                           Clinical Pharmacology
                                                                                                                                                           a»3 Tberapeotics
                                                                                                                                                          EooTet,  s.
                                                                                                                                                          Gilbert,  c.
                                                                                                                                                          Ganleboot, C.
                                                                                                                                                          faction,  p.
                                                                                                                                                          19«o
                                                                                                                                                          British  B«iical  Journal
                                                                                                                                                          280(622«)s1l6»-iis?
                                                                                                                                                                                         00
                                                                                                                                                                 S.p.
                                                                                                                                                          Jnslto,  v.j.
                                                                                                                                                          1975
                                                                                                                                                          Clinical PhacaacologT
                                                                                                                                                          and Therapeutics
                                                                                                                                                          18(«):475-«B«
TISStJt
5208
Biooa


tlPOSOSB ROUTE
— 	
Inqeatloa

.
aiuTtfcii 	
RITBOD
Colortaetcy


ROHBES
OF C1SIS
a| 1
b) 1
c) 1
aiisi
aj lot applicable
b) lot applicable
c| lot applicable

a) l.t pp.
b) 3.7 pp.
C) 19. » pp.
                                                                                                                                '" 3 ht
                                                                                                                                         hr
                                                                                                                        *r«»: BIO°D; TO1"5 S03CTDE;
                                                                                                                        TTSTOBIKs MSTHMUKOS
                                                                                                                                                                  BEFZIERCE
                                                                                                                                                                  ...
                                                                                                                                                           Orost. S.H.
                                                                                                                                                           Dome. J.d.c.
-------
                               -,  4ichlori«»
1» 10-42-5
C12-B14-M.2C1
t» 408. IP 300 C (decoap)
                                                                                     (COITIWUED)
 J9-B32-014
 1 €04.81
   «SSBE
  5,0,
                       BOWB
                                IIIMMCU,
                                  BETBOJ)
                               C.lorl.etrT
 IMB™
OP C1SSS
                                                                                                                           'GEH11I. IBFOBBaTIOB
                                                                C)  lot
                                                                                          ..  f,  „
                                                                                          g  »'
                                                               a)  25 rt old (an 3 hr after inqestion

                                                                        '" -0'" 2* te '"«
                                                                        „„ .„.„ 5 hr aft«

                                                                            for days 1-7 for ,).
                                                                                                                   Talnes

                                                                                                                   PISTICIDBS;  B1OOD:  BRIIS:  SBICIDE;
                                                                                                                   CISE HISTOBIIS;  IBTHEBIMBS
 i-B*«eth»l«PiPOdophyllotoxin ethyliaeiw-beta-B-glaeosida
   1ISSQB
 S210
 Blood.
 Tlana
5211
Cerebcasp
inal
fluid
              EIPOSHBI BOBTB
              Inj«etion
             Infection
                                1UITTIC11
                                  RZTBOD
                               Balloietrr
                              BaiiomttT
 BBBSBK
or ctsss
                                                                         I1B6I
                                                               2*. 31-45. 88 ug/al
                                                               0.015-0.13 «g/al
                                                                                           31.11 ng/al
                                                                                           lot  applicable
                                                               teaits, after 1 hr IT of 363-5*0 mg.
                                                               tritiatel dose.  Bierponential decar.

                                                               lonresponding cancer patients, aqes
                                                               •1-63 ye, *ith adequate renal
                                                               function, 2-8 *1t after preTions
                                                               ch««otharapT.

                                                               shite blood cell conn* decreased
                                                               0-63* at da? 8.

                                                               MOSS: MIS TBWAOT; CBSHOTBIEHT;
                                                               ««CPt»SlS: EtOOD P&AS11;
                                                               CMEBSOSPlml F1BIB; TECM
                                                               2-26 hr after 1 hr IT of 363-130 aq,
                                                               tritiated dose.

                                                               Rourespoadinq cancer patients,  aqes
                                                               «1-S3 TC. «ith adequate renal
                                                               function, 2-8 v* after prerions
                                                               clecetharapT.

                                                               «ite blocd cell count decreases
                                                               0-63* at dar 8.

                                                               BSBSS;  1SOS IHER»PI;  CH!HOTHES»Pt:
                                                               ifcpusis;  BIOOB ptusai:
                                                               C«EE9tlOSPT!l»l FLOID;  TECES
»an Bij*,  ».

KUl. Yi '
Do«e. J.B.C.
        t. l.S.P.
                                                                                                                                                                5 of Toxicology
                                                                                                                                                         31:129-136              I

                                                                                                                                                                      	I
                                                                                                                                                                 SEKSEBC!
                                                                                                                                                         Crearen, P.J.
                                                                                                                                                         alien,  L.a.
                                                                                                                                                          Clinical Pharmacolo^j
                                                                                                                                                          and Therapeutics
                                                                                                                                                          18 (2): 221-226
                                                                                                                                                         Createn,  P.J.
                                                                                                                                                         Allen,  L. fl.
                                                                                                                                                          Clinical Pharaacology
                                                                                                                                                          and Therapeutics
                                                                                                                                                          18(21:221-226
-------
                                      ^^«^«5-!,
5212
Mool.
vlasna
Iigeation
nc
tellometrr
ec/HS
                                                  »>  S.52-U.71
                                                  *>  2.68-10.22  ng»
                                                  c)  2.06-9.17 ng/«l
                                                                                         «•  8.72  » or  -  1.4»

                                                                                               13  * ot  -  1J»
                                                                                               u  . or  -  1.05
                                                                              (SI)
                                                                                     a)  Peaks
                                                                                                     21-«8  Tr  oia«,  Biciigan
                                                                                                                             Iberts, 7.5.. Jr.
                                                                                                                             Pbiloponlos. B.S.
                                                                                                                             Feineke, I.g.
                                                                                                                             »lick. S.B.
                                                                                                                             1981

                                                                                                                             Clinical Pharmacology
                                                                                                                             ana Th«npeutica
                                                                                                                             29(1)! 81-93
                                                                                                                                  
-------
 5-Thia-1-«abicyclo(«.2.0)oct-2-ene-2-carboxyllc acid. 3-(((5-Mthyl-1.3,a-thiadiazol-2-yl)thio)i«tliyl)-8-oxo-7-|2-(1B-tetratol-1-yl) aeetanido)- (8 CI)
 5-Thia-1-a*aticyclo(».2.0)oct-2-ette-2-c«rboxylic add. 3-(((5-iethyl-1,3,«-thiadiazol-2-yl)tbio)Bethyl)-8-oxo-7-((1S-tetraxol-1-ylacetTl)aiino|-, (6F-trans)- [9 CI)

 C«-B1»-I8-O»-S3
 RS «««.5, «P 198-200 C
                                                                                       (CORIIISD)
TISSDI

5216
Orln









5217
OtiM













EIPOSUSS BOOH

Injection










Inflection














AEALYTICAI,
BETBOD
Rierobiological










EPIC














IDHBEK
OF CASES
IS










6














HISS

a) «1-7M of dose
b) 17.3-56.2* of dose









n) Bot given
b) lot given
c) lot given












RE1I

a) Rot applicable
b) lot applicable









a) 801 of dose
b) 51 + or - 8t of
dose
O 83 * or - It* of
dose










GEXCF.II. IIFOBRiTIOR

a) Controls
b) Breiics
emulative excretions »-»8 hr after
500 ig 11. Data also for iiltiple
doses*
I
loriai 25-»0 yr olds. »0-73 yr old
ureiic mi vith cardiac and renal
diseases.
rBBGS; ABTIBIOTICS; BLOOD SEBUR;
DSIIIE; ADOL1S; DISEASES; CORPABAtXTE
IfllBlTTOHS
a) Freoperative, 1 snblect
t) During surgery
c) Postoperative
5 hr emulative excretion after 7-10
•in IT of 1 or 2 g (exact dose not
given) .

•8-71 yr olds. 52.7-197.S kg, »ith
cardlopnlsonary bypass surgery.

EfiUGS; ARTIBIOTICS; REASOBEHnT
RITBODS: DBIIE; BLOOD SEED!!: ADOITS;
SDBGEBT: BII5T DISEASES: COHFABATIYE
tTAIOATIOHS
1
BEFEBSRCE I

Belling, P.O.
Craig. t.A.
Anidon, G.L.
Kunin, C.R.
197»
Clinical Fhariacology
and Therapeutics
15(»):3M-353



Riller, K.s.
"ecoy, B.C.
Chan. K.K.B.
Fischer, E.P.
lindsay, V.G.
Seifert, B.D.
Zaske, D.F..
1980
clinical Fhariacology
and Therapeutics
27 («): 550-556.




5-Thla-1-azabicyclo(*.2.0)oct-2-ene-2-carboxylic acid.  3-flirdroxy«etIiyl)-»-o)B>-7-(2-|2-thieBTl)*eetamido)- acetate (ester)  (3 CT)
;-Tkla-1-axatieyelo(«.2.0)oct-2-ene-2-earboxylic acid,  3-({acetyloxy)Hthrl)-8-oxo-7-((2-thienylacatyl)anino)-.  (CD-trans)- (9 CI)
113-61-7
Cie-H16-I2-oe-S2
BB 396.«»
                                                                                                                                                                                          NJ
llSSdl

S218
eiood.
serai













5219
Blood,
sent




EXPOSURE B001I

Injection















Infection






IIILTTICII
BETBOD
BPLC















Bicrobiologlcal






»0g BEX
or cisis
i















«






J1IGE

a) 60-12 nq/al
b) 100-23 ug/nl
c) 30-3.7 ug/nl
a> 1«.5-7.7 og/nl
e) 68-1*. 5 ug/al
f) 9.0-1.H 09/1!










5.9-0.7 qq/tl





-
HEIR

a) Rot given
b) Wot given
c) Rot given
d) lot given
e) Rot given
f) Rot given










lot given






GEItBkL IRFOSIUTIOI

a) Cephalothin. day before surgery
t) Cephalotkln, day of surgery
c) Cephalothin, day after surgery
d) Deacetylcephalothin, day before
surgery
e) Deacetylcephalotbin* day of
surgery
f) Deacetyleephalotliin, day after
surgery
30 and 120 sin after 2 g cepbalothin.
IT. Other patient data available.
5« yr old patient. «t 8» kg.
cardiopulsonary bypass snr'gery.
CBtISS; TODS tB!BA?T; IRTIBtOTICS;
»IOOD SEBHH; BElSTOJIJirT HMHODSj
SntGIHT: NNIB01ITES
1 and 1 hr after 1 g
Vange a! leans

iruLTS: Bioct s»soi; BTIK;
11TI3IOT1CS; DBDGS; HCTWIOB


BEFE5ERCE

Killer. 1C.».
Chan, K.K.K.
McCoy, H.G.
Fischer, B.P.
lindsay, U.S.
Zaske, D.E.
1979
Clinical Pharmacology
and Therapeutics
26(1):S«-62






Kafetzis. D.H.
Siafas, C.It.
Georgakoponlos , P. i.
Papadatos, C.J.
1981
let a ?aediatrica
Scanainavlca 70:295-288
                                                                                     (Itlt Fast)
-------
5-TW«-l-«MUCTClo(«.2.ff|oct-2-«.e-2-c«rlx>rrlle acid. 3-fhTaro*7»etBrl»-8-o*»-7-(2-f2-tBleByl|aceta.ido) - acetate fester) 18 CI|
S-TBia-1-«afeicrclo <«. 2.0) oct-2-«'Be-2-earlx«|rlic acid, 3-«(ac«tjlo*r)Beth7l|-e-o*»-7-((2-tBieBTlacetTl)aBi»o>-, (8S-tran9)- (9 CI)
1S3-41-7
C«-H1«-»2-0«-S2

11 "«•"
TISSOB

5220




. . . _
SKPOSOBS BOVte

In1«ctiatt





1H1TTICIL
BITSOB
licrobiological





ITTBSIH
or cists






11IGI

0.0-0.16 iig/Bl





BS1I

Bot giren





GZIZBaL HFOSB1TIOI
	
2 an! 6 he after 1 9. Initial
aeasureeent , 0. 27 uq/al at 0.* he
?a>ge of Mi us

HCOUS ; BIOO9 SZB1IR: HILK:
IITIBIOTICS; DBDGS; IKCTktlOI

SEfEHISCE

Fa fell Is, D.I.
Siafas. C.K.
C*otqakopoaloE. P.I.
?apadatos, C.J.
1981
Icta Paediatrica
SciBlinaTica 70:285-288
S-»i»-1-axaUcTCl»<».J.O)oet-J-«fte-2-carb
-------
5-Ihi.-1-.»Ucyqlo«,.2.0>oct-2-e.e-2-carb<»nic.cid. 7-
«0»25-«1-3
CSO-B21-»"MJe-S2
eg 51*. «o
                                                                                                      1- (c.rto.T«thTl,-1-H-tetr«.l-5-rl)thic, .ethTl)-8-oro-. <68-tra«s>-
TISSUE
5225
Blood,
Tlasia
_
EIPOSOEE none
Inflection
IfalTTICU
HETHOD

•OBBEB
OF C1SES
_
Hiss ~
210-8 09/1!

lot given
"GE1IML IIFOMWIO*
C.S an« 12.5 hr after 32.3 ig/kg IT
Istiiated frci graph
Eata also foi logs, rabbits.
1ITT"IOTIC5: B1O09 PlASIiJ
CCBP18MITE mi.O»TIO»S: IBTaBOlISB;
COGS
EEFEBEFCE
Siyth, S.D.
Rottendorf, G.H.
1980
Toiicoloay and Applied
Phariacology 53:179-195
•i-t.i.-1-.x.tlcyclo (•>. 2.0) oct-2-e,e-2-c.rbo«Tlic .cid. 7- (
SC370-12-2
C16-H1T-I3-CE-S
Hi 3«3.*2
                                                                                              » -3-ietnTl-8-«o-.  (6K- C6alpha.7bet» (**) ) ) -

TISSUE
5226
flood.
serai
522T
Blool.
serai
5228
Blood,
serai
5229
Bilk
5230
Urine


EIPOSDEI ROD1B
Tngestion
Ingestion
Ingest ion
Ingest Ian
Ingestion


lillTTICil
HETHOD
•icrobiological
lierob iological
Dicrobiological
Hierobiological
Hierob iological


ID8EIB
OF CiSSS
13
20
6
6
13
.


U»GB
a) 8.981-0.298 ag/il
b) t7.841-C.619 ag/il
a) 0.3-33.4 ig/1
b) 12.0-56.5 ig/1
c) 0.1-3».8 ig/1
11.6-21.6 ag/il
0.10-1.6* ag/il
a) lot given
b) lot given


1 sii»
a) lot given
bt Hot given
a) 5.92 ig/1
b) 27.38 ig/1
c) 10.8* ig/1
-
fot given
dot given
a) 89.92* of dose
(221.8 ig)
b) 86.3*^ of dose
(«31.7 ig)
VISE)


a) leans, 1.5 and 7 hr after 250 ig.
Initial value, 3.282 ag/»l at 0.5 hr
b> Beans, 1.5 and 7 hr after ?00 «g.
Initial value, 6.369 og/il at 0.5 hr.
Health T 20-29 yr olds, «t 62-85 kg,
fasted before and daring stady.
TSOGS; UTIBIOTICS: BIOOD SIFU1;
•cons: iTkiu nsmE
a) 0.5 hr after 1 g
t) 2 hr after 1 g
c) 12 hr aft« 1 g
feaV nithin 2 hr in 70^ of patients.
26-77 yr olds, »t 43.8-130.2 kg,
fasted overnight-* hr after dose.
C»BGS: USTIBIOTICS; 1301TS; UHISE;
UCOD PLtSill
1 and 3 nr after 1 g
lange of leans
icni'S; B100D SEB1J9; SItK:
1ITIEIOIICS; DE06S; tlCT»TIO»
1 and 6 after 1 g. Final
•easnreient, 1.16 ug/il at 9 hr
Cange of leans
t CULTS; BIOOE SEBOB: SILK;
urtisroTicsj DRBGS: HCTITIOI
a) 259-ig icse
t) 500-ig dose
0-2« hr excretions
Bealthy 20-29 yr olds, «t 62-85 kg,
fasted before and luring study.
ttUGS; »«TTBIOTICS: BLOOD S5B11:
SEtltTS: ITalt; UBISB



Prenna, R.
Eipl, S.
1980
Cieaotherapy 26:98-102
Catter, P..E.
Blair, *.D.
Kelly, B.B.
1979
Clinical Phanacology
an! 'herapentics 25(5
pt 11:511-521
F.afetzis, O.A.
Siafas, C.a.
Georga^opoulos, P.i.
Papadatos, C.J.
1981
»cta Paediatrica
Scandinavica 70:285-283
Fafetzis, D.t.
Siafas, C.a.
Georgakopoalos, P. a.
Papadatos, C.J.
1981
acta Paediatrica
scandlnavica 70:285-288
Prenna, B.
Fipa, S.
1980
Cheiotherapy 16:98-102

-------
S-Thia-1-atabiCTClo («. 2.0) oct-2
5C370-12-2
C16-B17-I3-CS-S
gi 363.«2
                               -•w-2-c.rbo.rlic add. 7-{(ami»c(*H,raEO«rpl«arl)ac«trl>a.i.o|-3-.eT:l,yl-8-oxo-. {6«-<«.lP»».7bet.OI«)»-
                                                                                      (COITIMED)

TISSUE
S231
Brine


Bitosvis BOOII
Insertion


illlCTICaL
RVTHOD
_ 	
licrobioloq-ieal


mm
OF CUSS
19


B11CJ
'
10.6-105.81 of dose


Bill
68.3* * or - 26. 8* of
dos«



0-«8 hr cuanlatlre excretions after 1
9
2S-77 YT «"«. «» »3.8-130.2 *I significantly different. 1
1 Healthy cancasian 19-28 yr olds. »o 1
1 Etrennoas exercise. 1
• 1
1 CSHGS' 1ITIBTOTICS; aQDLTS; SEX: 1
1 BIOCO SEBOS; COBPa»»TITB EVMDWIOHS; 1
1 nine J
i 	 _ 	 	 ' 	 	 	
a) 88< of dose (»18 I a) Bales, ^•JJJ^J'ljJj",, J Erannick, llj!
bl 73% of dose (3*7 • | c) "ales, *ej*°^*14 \ seis"*E!s*'1'
I?' 80* of dose (380 ! J«-S"cZi«Utiv«*.xcr«tlOBB j 18 (2)": 215-220
flNo* of dose (332.5 ' Bealthv Caucasian 19-2S rr olds. Ho 1
lqt | Etrennoas eiercise. 1
i 1
1 t'BBS: HtlBIOTleS; JBB1TSJ SSI; 1
1 noco ««u«; eovsnvnn EV»to»Tio»s; i
I «M« J
1 1 	 .—•-—. — ' —II 1 — — ...

                                                                                                                                                                                              Ln
-------
                                                                                                                                  -e-«o-. ,6B-(6alpha.7beta (*.)!)-
Cl8-B18-»«-OS-S2
11 "62. 5»
IISSBI

523«
Blood.
plasna






5235
Brine









Birosnts BOOT i

Injection






Injection









AlALTTICAl
HETBCO
BPLC






BPLC









BOHBEB
OF casss
12






at 1
b) 1









5-,.l.-l-.t.blcyclo(..2.0,oct-2^..-2-c.rbo«,lic acid. 7-t2-,.l
ilB6S

a) 70-126 ug/«l
b> 46-80 ng/1
c) 21-37 agynl
d) lot given
e) lot given






a) 600-100 »g/»l
b) 350-100 ag/nl











a) Bot given
b) Bot given
c) Bot given
d) 81.68 » or - 1«.5»
ag/nl
e) 3. S3 * or - 1.2»
ag/nl






a) Bot given
b) Bot given











a) After 10 lin, daring dialysis, 6
catlents
*) After 30 ain. daring dialysis. 6
catlents
c) After ».5 hr of dialysis, 6
patients
d) 28 hr aean, interdialyeis, 3
patients
«) 28 hr neat, 6 controls
tese, 15 ng/kg.
52-52 yr olds, «t 5»-68 kg. »ith
chronic renal failure, on
heaodialTsis. Healthy controls.
IBU6S: ANTIBIOTICS; BIOOD P1AS1J:
tlSBASKS; 9HIBE: CORPABATITI
a) 22 yr old »lth *rlne ontpat of 600
•I/day, 2-hr and 12-2» hr eicretlons
after 15 ag/kg
t) 52 yr old »lth nrlne ontpot of
<100 nl/day, »-hr aad 15-20 ir
eicretlons after 15 ng/Xg

f.3.6 and 68.2 kg patients, lith
chronic renal failure.

ElOeS; AWIBIOTICS; BLOOD ?LASHA:
tTSEASK; OSIBS; CO«PASATIT1
IVILOATIOBS: ADULTS
1 	 — 	 • 	 — —
BEFEBEBCE


Ganbertoglio, J. 6.
Aziz, B.S.
lin. 2.1.
Graasz, B.
Baughton, J.L.
Eenet, L.Z.
1979
Clinical Pharaacology
and Therapentics
26(5):592-599





GaaDertoglio, J.S.
Aziz, B.S.
lin, E.T.
Grausz, E<
Paaghton, 'J.L.
Benet, I.Z-
1979
Clinical PharnacologT
and Therapeutics
26 (5) : 592-599



onbenylacetyll aninol — 3— nethyl— 8— ozo*. (6B— (6alpha. 7beta(R*)))— (' C!}
C16-B17-I3-C«-S
II 3»7.«
HSSHB
5236
Blood,
a«rna
.
S237
Bilk

EtfOSVn ROOTB
Ingestlon
Ingestlon
--
1I11TTIC11
HITIOD
licrobloloqical
Bicroblologieal

BOBBH
OF ClSIS
S
«

OICI
.
22.9-13.6 uq/al
0.20-0.50 uq/il

8EiI
lot given
Wot given

GtlEBaL IIFOaBaTIO*
1 a«d t hr after 1 g. Final
aeaanranent, 2.7 ng/al at 3 hr
-------
            z) az«pi..-s-e.rbo«.ta.
C1S-I12-V2-0
•t 23*.2«. IF 204-20C C
1ISSVI
S23t
Blood
523*
Biooa.
tiasi*
S2»0
float.
Plan*
Jlool.
s*mi
crnsna MO*B —

lB,qej«tioB
	
-' 	
1IU.TTICIL
ratsas

•s
cc
OC/BS
•onn
or cisss
2
S
10
6
HfGI
•1 lot giTm
b) lot give*
c) lot given
41 lot given
•1 lot glvci
f) lot gives
9) lot given
h) lot given
1) lot gives
J) lot give*
-
7.80-3.10 ag/Bl
•) ».6-7.7 Bg/1
b) 0.31-1.01 ig/l
a) 1.55-3. 12 ng/il
b) 1.79-2. tO ng/Bl
C) 1.33-2.10 «g/Bl
BMI 1 GSIEMl Iiro«l»TIO»
	 _ 	 1— 	 	 	
b! »'s5 ".i?^1 ! I.1 c«"«««Fl»«. "tier, 2nd d.r
« 5'S !»l^t * CjcbawMFl... child, 2nd d.T
2 7 . HJ ' c) 1(>."-ePo*T c«rba.»T«pin«
« i'J *°KJ ' «««t«l»Ht«). .otker. 2nd da;
S S:i ::i;i | !ia1S;;''ei>OIT *«»••*««*". =«id.
!! o'2 !^J^J ' t1 C«rt«»»«Pl««. "ether. 3rd «.T
l! !; n ( , ' f| c«>»««*«Fi»«. cllld. 3rd day
i! "sv.:^1 i Ua's.;1-'0" «*•""-*«. •«-.
1 b) 10,11-cpory carbaHz*piB«. child,
1 3id day
1 t| Catbaiazcplae. mother. 30th day
1 jl CacbaaaicFlne. child, 30th day
1 »»liea for «tt«r delirerT-
1 Patient took 8 «flA« cacbauzepine
1 aid « «q/*
-------
«B-eib«M Cb.fl «xepi»e-S-c«rtox»mia«


115-B12-I2-0
CI 23C.26. » 204-206 C

1ISSIS
5242
lllk






5243





5244
ori»e









BiroSOBE BOflTB













Ingest ion







-

IBILTTICU.
BETBCD







OC





CC









BOBBEE
OF C1SBS
1






7





5









IIKS
a) lot gi»«n
b) lot given
c) (ot given
d) lot given
e) lot given
t) lot given






1.17-1.7* as/1





a) 0.35-0.87* of dose
b) 1.02-1.41* of dose
c) 32.7-60.6* of dose
d) 5. 17-8. SOT of dose









BEIB
at 7.5 a Ml/1
b) 2.6 u nol/1
e) 5.5 n aol/1
d) 1.8 u aol/1
e) 7.5 a aol/1
f) 4. 4 n sol/1






1.37 ag/1





"
a) 0.52* of dose
b) 1.14* of dose
c) 49.9* of dose
d| 6.80* of dose








. 	 — 	

a] carbaiazecine, 2nd day
t| 10,11-epoiy carbanazepine
(tetabolite), 2nd day
c) Carbasazecine, 3rd day
d) 10,11-epoiy carbaaazepine, 3rd day
e) carbatazeplne, 30th day
f) 10,11-epory carbanazepine, 30th
day
Patient took 8 ng/k? carbanazepine
and 6 ig/kg dlphenylhydantion daily
durinq gestation and lactation.
DROSS; BIOOD; lactmos; BEWSOBI:
IIT1BOIITES: BIIK
U— 	 — 	 — 	
liter daily doses of 5.3-21.0 ng/kg.
Saliva and plasaa levels r-0.991,
ratio-0.26 + or - 0.01.
17-63 yr olds on lonq-tern treatment
for epilepsy.
IS06S; slTICOBVUlSMTS; BIOOD PUSH*:
SS1TTR* CO^Plfi4'I^S BYUi U1HO1VS »
-------
SO-*7-S
C18-B22-I2
Bl 2<«.37. B* 172-17* C at 0.02 aa  Ba

TISSUE
52«
Blood,
plasaa
1
1
1
1
|
1 	

neoson BOOTS
Ingest Ion


iiunicit
HETBOD
Sit
1
1
I
1
1
1
1
1
1
1. 	 	 	

IOHBSS
OF CIStS
al 1
14 1
c| 1
1
1
1
t

max
a) 43-30 ng/nl
b) 18-1.9 aij/al
c) 7-0.4 ng/nl
1
1


BB1I
a) lot given
b) lot given
c) lot given
1
1
1
1
1
1
1
i

GEVEBaL IITOBBaTIOB 1

a) 7.5 and 72 hr, patient »lth lo«
Beta phase values
b) 7.5 and 72 hr, patient «lth »edinn
Eeta phase values
e» 7.5 and »8 hr. patieat «ith hiqh
Beta phase values
liter 50 nq as the hydrochloride.
ictinated £ron qraphs •
leta phase, aonoexponential tecninai
decline
tegtessed patients, in qood rhyaical
health, fasted overnight and » hr
after I.*, dcse.
MOSS- 0»lJG T.BBBUI: IBMBEWBSSXTE
a«EITS; S100D Pl»S«l; SBTUOLITES

BEVEBERCE

Brnnsvick, D.J.
Aasterdaa. J.D.
nendels, J.
Stern, S.I.
1979
Clinical Pharaacology
and Therapeutics 25(5
pt 1): €05-610


i Jibe Ib tlazepine-5-propananine. 10,1vaihl4ro-»-nethvl-, nononT«irocBi.oiitt« »> v-^i
««-28-S
C18-B22-I2.C1-1



C« 302.88, » 214-218 C
1 iissni

52»7
Blood.
plaaia
1
1
1
1
l_ 	
1
Blood.
pla*aa



	 _— 	 "UBCII 	 1 "" ' bliinai. iiruan.-*-.
1W | BETBCD » O» C»SBS 	 _ 	 _
	 	 9 m) 12_30 mfl/ml ., 21.,, »,/.! a> 3 hr after M> aq <
Injection w- 1^. fo-28 no/*l hi 19. n ng/ai =1 uc a
lose

Healthy 20-59 yr olds. London.
1 tnq la *

1 1 IB9SS; B100D Pt»S1l»: IDtJWS;
1 | CCS91BMIVJ »f»m»TIOIS: 01ITED
1 1 1 micnoi
1 .1 	 _ 	
1
Inqestion 1 5C
1







_ 	 — 	 |
J b) lot given 1 b) 71 « or - 37 ng/al 1 « ^j^atter1?1^
1 ! 1 bedtlse.
I | 'aaretie boys, sean

I Increase in plasaa
I staadln?. Sise in
I Eiy aoath.
i

caainc
» 7* no/day at
aqe 9.8 » or -

norepinephrine on
sopine pulse rate


1 D*nes; canwEi: SLOOB ?BESSOSB;
I neon ptissi: DFOS
i 	
TBtBlPI



| BirESERCE 1
5
1 Ehsannllah, F..S.3-
I Qhose, K.
1 Flrby. B.J.
1 Turner, ?.
1 altts. D.
1 1977
1 PsychopharaacoloqT
1 52:73-77
1
1 lake, C.5.
1 l!i*kelsec. S.J.
1 Papoport, J.I.
1 Fopin, I.J.
1 1979
1 Clinical Pharaacoloqy
1 an9 Therapeutics
1 2«C5):««7-€53
. 1


' '
!
	 — 	 — 	 (MIT B»B«
                                                                                                                                                                                           .O
                                                                                                                                                                                           vO
                                                                                                                                                                                           VO
-------

C18-H22-B2.C1-B
II 392.18, IP 21«-21B C
                                                                      (CORIIVED)
                                                 15SO-1580 »g/«l
                                                                             1570 ng/«l
                                                                                                              GE1EB1L
                                                                                                                    Ccaks.  Data for nlied
                                                                                                                    desipr*iine-BCl and iilprailne-BCl
                                                                                                                    overdose also aTallable.

                                                                                                                    Overdose patients, ages 17 an* 22 Y*-

                                                                                                                    OJS Interval of 190 nsec or greater
                                                                                                                    on ro«tin« ECS, aaa o«o or lore of
                                                                                                                    tb« follovlng
                                                                                                                    atnornal deef tendon reflexes,
                                                                                                                    ventricular rate of 120 beats/Bin or
                                                                                                                    
-------
                                                                    CD
CW-B2«-«2

1ISSOI

5252
Slood,
flasma

I
1
1
1
1
1
I 5253
I Hood,
1
I
1
1
I
1
1
1
I


Bitoson -ow« tinmen
BRBOB

Ingestion OC

1
1
•
1
1
1 1
I 1
| Ingest ion 1 Bit
1
1




1

IOSBM
or etas







1





i
i
i
	 . 	
	 __.-_ , .-„ miiti zmsuTKH
28 « or - 21 ng/ml It » »S after 2 «k on 7S mo/day at
bedtime.
lincetic boys, mean aqe 9.8 » or -
1.9 yr.
try month. Increases In sapine and
1 standing p«lse rate, diastollc blood
1 pressure, and plasma norepinephrine.
1 cizziness on standing, seduced
1 ecvresis.
| MUSS; C-119S-B: B100B PBESSOSE;
1 U.COD eilSUl: B806 TBSBa»I
I 	 1 	 — 	 	 ~ 	
1 . t m\ mi** MI won 1 al -t alp rM -.!»€• Bio-tponfintlal acclln
| a) 20-0.8 ng/-l «1 »* 9£« t> Deseethylinipramlne (aetabolite) .
| bl 13-* ng/ml BI sot given i goBOeIpl>seiltial decline
1 | 7.S an* 90 hr after single dcse of i
1 l mq as th« hydrochlorile
1 | titlmatea from graph.
I ncalthy -tolnnteer fasted o-ernight
1 and » hr after US. dose.
I '. nsoss: BBHG IBBHUT; MTIBBPBESHTB
t J leiins: sices ntsats B-TtBOLiiss

~j EEFESUCI
1
1 	 ____
1
I Lake, C.B.
1 MlUelsen. l.J.
I Sapoport, J.I.
I Fopin, I.J.
| 1979
1 Clinical Pharmacology
1 and Therapeutics
I 26(5)s«»7-653
1
1
1
• 1
,
e 1 Brnnsvick. D.J.
I tisterdai. J-0.
I Rendels. J.
0 | Stern, S.L.
| 1979
I clinical Pharmacology
and Therapeutics 25(5
pt 1):605-610




                                                                                                                                                                                          Ln
                                                                                                                                                                                          O
    113-52-0
    C«-B2m-«2.Cl-H
                                                       ^
"
l~













I
Hood,
tlasma

1
1









iXIOSVR. S001I
,.,-sUo,












iinmcu.
HIIHOD
ec/sr









1
1
i 	

or c-sss
1












BUGS 1
1
Bot applicable












1
	 1 	 	 	
1950 -a/ml 1 leak. Bata for mixed i.ipraalne-HCl
1950 »g/ml i ^ aesipramlne-HCl orerdose also
I available.
| Cterdose patient, age 29 yr.
1 CIS of 100 msec or greater en routine
| ICS. an! one or nore of the following
1 atnormal de«p tendon refleies.
1 ventricular rate of 120 beats/iin or
| greater, right handle branch block,
| atrial and ventricnlar premature
I contractions. Innctional and
I Idioventricnlar arrhythmias.
i unconsciousness, respiratory support
I necessary, grand aal seizures, ana
1 death.
1 CB«GS; M-I3M1BSS1TB ICMTS: 3MO9
1 imsnt: trvc, IBOSE; ntssoosi
i 	 — 	



Biggs, J.I.
Spiker. D.G.
Petit. 3.S.
Zleqler. 7.B.
19T7
Journal of the amerlcan
Fedical Issociatloa
238(2) : 135- 138






1
1
1 	 	 	

-------
SB-mbe«o{a.« ciclok«pt«.«-«.lt.<5,.J»..a)-propll«.i»«.  1.
1-Propaaa*lae, Vt19,11-dibydro-5H-dib«««o(a.a)CTclob«pt«B-5-Tli dene) -»-aetByl-  C»
C 19-H21-1
11 263.37. IP 213-215 C

tXSSBE
S255
Blood,
plasaa
5256
Blood,
plasaa
_
5257
Blood,
seen •


BIKS9BE BOOTS
iBoestioa
IngestiOB
iBjectioB
lagestioa


uitmcn
HETHOD
SC
"
Badioaetry
GC
...

itnBEB
or cms
12
c
9


I1IGI
	 — 	
a) 31-38 aa/Bl
b) 52-38 ag/al
a) 670-1500 br a«/l
b) 1430-3030 br ug/1
50-B50 ag/al



a) lot applicable
b) lot applicable
a) lot gi»en
b) lot given
lot gives
--

	 GiilBii iKosamoB
	 	 	
a) 0 and 2« br after 6 daj regleeB of
3 1 25 eg/da? as tablets. 36 ng/«l
at 7 hr
tl 7 and 2» br alter S Say re«iBen of
7« BO/Say slB^le tablet. laitial
Btasnceaent, »1 »<1/»1 at 0 hr.
B«altliT 18-60 Jl Ol4s
«I1T!D KIIGDCE: BLOOD; BtOOD Pl»S«»;
icons: niHtons STSIOT DISMSSS; DSDS
THIg»PT; COMlBiTITE gT»lOWIO»S;
IITIDBPMSSITE »SS»TS
a) Jfter SO *j iac-labellea dose.
t) after *0 Bq 1«c-labelled dose, IT
Irea nnder the carre data
BtalthT. 21-28 ft olds OB »o otber
i«dicatioi>.
SCM sedative effect in Boat.
HFBSS: Di»a»fK: BLOOD FllSHi;
COHP»B»TITI IfllHTIOSSj IDOLTS
— — — 	 ' ' —————— —^
12 be after last dose of 50 *j 3x/«ay
fcr 2 »*. Talnea estiaatefl froa
qtapb.
Jcspitalired patients.
D10SS; BIISOSBBIIT BITHODS; CE»B»BK;
IIOOD SBHOS: »»TIDJPFBSSITI »SSITIS

tEKSEHCI

Hacker, H.B.
staaffer, S.c.
Clayton, F.G.
lakra, B.B.S.
Gaind, B.B.
1975
Journal ot Clinical
Pbartacologi 15:168-172
	 	 	 — — 	
Graa, L.F.
OTero, K.T-
1975
Clinical Fbaraacology
and Tberapeatics
18(31:305-314
Jorgensea* &•
1975
Acta Pbaraacoloqica et
Toricologica 36:79-90

                                                                                                                                                                                           o
                                                                                                                                                                                           ro
                                 ^^^^
•l°277?39, at Hydrocbloride 196-H7 C
   1ISSOB
  52S8
  Blood.
  plasBa
EHOS0B3 SOOTB
IngestiOB
	 .
IHLTTIClt
RBTBOD
'"
sc/as

OF CiSSS
12

SatSE
a) 29-151 ng/al
b) 5-179 ag/al
c) 5-21 ag/al
d) 53-130 ag/al
e) 26-112 og/al
f) 12-258 Bg/Bl
(BUT
flBll
a) 81 * or - «o ng/al
b) 71 + or - 57 ag/al
c) 12 « or - 5 ng/al
4) 91 « or - 30 ng/al
e) 82 + or - 27 ng/al
f) 176 » oc - 6»
nq/«l
?15B)
                                                                                                                             GIBZBll IIPOBHKIOS
   laitriptTliBe
   nortriptiliii*
   10-Hy^ro*yaaitriptyliBe
   10-lTlroxyaaitriptTlihe conlogate
   10-Hyiroiynortriptyline
.,  10-MTdro»yBortriptyline connate
HlaiaaB steady state Tallies on SO ag
aaitriptyline, 3r/day.

61. «-10». 1 kg aen.
                                                                                                                    EBBGS; SBMBCIITES;  WlStJBSB'BT
                                                                                                                    BJ18OBS! BiCCD  PL»SH»:  WTIDIPBISSItB
Garland, t.».
Boccino, K.B.
Bin, B.9.
Capano, J.
Fann, ».t.
1979
Clinical Phar»acology
and Tberapeatics
25(6):8«»-856
-------
•O-M-6

it rn.39, n «TdrocM.oria« »6-m c

1ISSVI
5259
Blood,
plaaaa




1
I 52*0
I Blood.
I plaaaa
1

1
1





5261
Blood,

1
1


1
i

inoson BOOTS i«M--«i i«
SBTBOD Of C
Ingestioi 6C 12




1 	 __ _____
I Xagestloa 1 8C/BS 20
i i
i
!
i


(
1
! lagestioa 1 8C »{
I 1 D>
1
1
1
1
1 1
1
I
1
1
I 	

BJS Bines
ISIS
a) (0-50 ng/al
b) 90-*5 ng/al



1 {
1 ... ,
1 a) 25.6-58.6 ng/al 1
1 b) 11.a-27.« ng/al
| c) 29-151 ag/al
| d) 5-179 ng/al
'
1
1
1
1
1
1
1

2 a) »7.5-7 ag/al
9 b) 20-2*0 aq/al
1
1







a) lot applicable a) » a»a 2» hr after 6 aaT reglaen of
b) Bot applicable ..LareaSn^SO^/.l'^1'"^^ 6
ana 2» hr after 6 daY regiaen of 75
ag/day single tablet. Initial
xasaremnt, 50 ng/al at 0 hr.
Healthy 18-60 IT olds
i
1 flllTIB KlUStOS; BLOOI; B100D fllSKl;
1 HUMS; DBtIG TEEBWT; COBPiBATIT!
M»1UWIOIIS; HTID*»BSSSIT! 1GISIS
a) 39.» ng/al •) Peaks about » hr after 75 ag as
at 71 t « - 57 ag/S 75 •^•'tphule^for.' Irt'SlT"
i dose of 50 aq 35t/day for aoath. 12
I :
-------

                                                                                                   8 3
SM-M-8
CJO-823-B.C1-B
tl 313.85. if 19S-M7 C

TISSUE
52(2
Hood.
Tlasea











EXPOSmi BOOTS
_ 	
Ingest ion












BITBOD
oc/Tir












BUBBEB
or c»SBS
7












BHGS
11M-2190 ng/nl












mi
1639. »3 ag/nl











	 eilEBll IIFORlATIOl

lean peaks. Data for slxed
anitriptyline-SCl ana doxepin-8Cl
overdose alsc available.
Overdose patients ages 19-»5 yr.
OSS of 100 ssec or greater en routine
ICG. and one or sore of the follooing
abnornal deep tendon reflexes,
ventricular rate of 120 beats/sin or
gieater. right bundle branch block,
atrial and ventricular prenatare
contractions, luactional and
idioventricular arrhythnlas.
unconsciousness, respiratory support
necessary, grand nal seizures, and
death.
BUSS; WtltfPBESSITt IGEIIS: BLOOD
EIASm; BS06 aBOSEj 1ISSOOSI

                                                                                                                                                                   SIFEBEBCE
                                                                                                                                                            Biggs.  J.t.
                                                                                                                                                            splker, B.G.
                                                                                                                                                            Petit,  J.I.
                                                                                                                                                            fleqler, T.B.
                                                                                                                                                            UTT
                                                                                                                                                            Journal of the aaerlcan
                                                                                                                                                            Eeaical Association
                                                                                                                                                            238f2) s 135-138
                      I-ol. 3-(1,2-di«thylheptyl)-7,8.9,10-tetrahidro- 6,«,9-trl«ithyl-
C25-B38-02
*f 370.63
ussas
52«3
SlOOd.
Flassa

ElfOSIB! BOBtl
injection

UllTTICiL
BBTBOD
tic
Sadlonetry

BDK8SH
or cists
3

BIKE
"
a) 1800-30 dpa/al
b) 1*00-11 Ip«/«l
(Itll
IISaB
a) lot applicable
b) lot applicable
—

                                                                                                                             GUISll IfTOEUTIOI
                                                                                                                    a) total radioactivity 0 and 72 hr
                                                                                                                    after dose
                                                                                                                    tj Unaltered drug 0 and »8 hr after
                                                                                                                    lose
                                                                                                                    range of leans after 200 nq
                                                                                                                    1»C-latelled drag. It. Estimated fro.
                                                                                                                    graph.

                                                                                                                    lornal 21-23 yr °w casnal larihaana
                                                                                                                    stokers,  to habitaal drag usage.

                                                                                                                    TachycarSia starting ID ^-20 aln and
                                                                                                                    lasting »-« hr after dose.
                                                                                                                    Hypotension peaking at 1 hr, listing
                                                                                                                    > 12 hr.  Dininess on standing.  Dry
                                                                                                                    •ooth and dcovslaess after 2 hr.
                                                                                                                    tnthoria in 1 patient.

                                                                                                                    CBBGS; S5TJ9CIISS: ILOOD PL1SBI;
                                                                                                                             (rai»B: Fscis;
                                                                                                                                                                   5EFESSKCI
                                                                                                                                                                                          U1
                                                                                                                                                                                          O
lenterger, L.
HcHahOD, B.
Archer, B.
Ratsaaoto, !C.
Bowe, F.
197*
Clinical Pharnacology
and Therapeutics
-------
                                                -7.8.9.10-t.tr.n,d,o- 6.6.,-trl.t.yl-
Bl 370.63
JISSBB
•rlne
cirosoii BOOTS
-
Injection
iliimcit 	
BRBCD
Badionetry
iolSS
OF CISSS
3
(COIT
iiiei 	
a) 2-3* of dose
b) 5-8* of dose
c| *-16* of dose
[BUBO)
nai
— 	
a) Bet given
b) lot given
c) (ot given

" SBIJWL IBFOmTIOB ' 	
a) » hr
b) 2* hr
c) 7 days
Cnnulatiye excretions as S of total
""J»;t}»ity. after 200 ng IT
HC-laeelled drog. Ha-|or excretion
•as in feees (53-61* in 7 days) .
Bornal 21-23 yr old casual narihuana
nokers. 10 hahitnal drtig Bsage.
Tachycardia starting in 5-20 ni. and
lasting «-6 hr after dose.
Sypotension peaking at 1 hr. lasting
L . ""inass on standing. Dry
south and drevsiness after 2 hr.
loihoria in 1 patient.
BBMGSs IBTIBCIISB: B100B PUSHi;

BSFZBEBCZ "
lenberger, I.
HcRahon, a.
Ircher, B.
Hatsnnoto. K.
Eo»e. H.
197»
clinical ?harnacology
and 7herapeotics
15 (») -360-386

C«-H11-«5-o3
II 225.2»
1ISS1S
52,. ¥lth
aJvanced cancer
WSS! CIMCTTOa.Wr; BLOOD rUSBk;
jsKSLiSr-siiois,?' "WIMW!
a) 0.5 «g/)tq
b) 1.0 ng/*,
c) 2." ng/Xg
J) 5.0 ng/*q
Cviulative 72 hr excretion of
fluchan^ea drag after 1 hr IT
»9-82 yr oia,. ,t 41-117 *q. ,lth
a<]>anc->l caacer
MUSS; CRVBOTHnin; BIOOB H»S1*-
ffisstjur.ga-jss?"""""
	 ———_____ 	 	 	

de nlranda, p.
•hitley. S.J.
Blon. H.E.
Keeney, B.I.
Barton, ».
Cocchetto. o.f.
Good, s.
Penstreet, 15. p. HT
Mrk, l.s.
Page. s.\,
Hlion, 5.B.
1979
Clinical Pharnacology
and Therapeutics
26(6):718-728
de Miranda, p.
mtlev. S.J.
Elan. n.t.
reeney, R.».
Barton. 1.
Cocchetto. O.F.
eool. s.
Reistreet, s.p. in
rirt, I.B.
Page, D.A.
Zlion, G.B.
197«
Clinical Pharnacology
»»d Therapeutics
26(5) ; 7 (8-723
-
                                                                                                                                                                                        O
                                                                                                                                                                                        Ui
-------
7B-»uro(3,2-o» |1)beMopTr»n-7-o»e.  f-»etlor»-
218-61-7
C12-B8-0*
El 2U.1I. ft 1*8 C

USSUE
S2«7
Blood,
plasia








Blood,








tlPOSOBE BODTE
iBgestiot

















iBitnxcai
BRBOD
00 BC







8C-EC







_____ _ — — —

BVB8SB
or CUBS
5







5










a) 6*-2t* Bg/sl
b) 180-590 Bg/sl







-
J50-700 na/Bl









BMB
a) 177 ag/Bl
b) 32« no/nl







lot given










a) Peaks, fasting. Peak tines V2.5
hr
t) Peaks, after intake of standard
breakfast. Peak tines 1-2.5 kr
liter 40 aq as 10 »q tablets. Peaks
in a) and b) differed significantly.
tealthy sales vith noraal renal and
hepatic function, fasting 10 kr
before dose and on no other drags.
OSOGS; SKIB DISEASES; SWSDEB;
D1IBITI01ET BiPIltlOB; JOODS; BWOB
PIISHI; COIPIBltlTB SV11U1TIOBS
Bang* of peaks 0.5-2 hr after about
0.6 so/kg as fast-release tablets.
Ill had < 30 na/Bl bT 5 hr.
SllghtlT pigvented, adults vith
fcorlasis.
Irrthen* in response to ov exposure.
leniitivitT related to sens levels.
r«0.78, p<0.001.
tinos; a SO^EIEBT H7TBQPS;
SItlTITIS; iBTTDEPFSSSIT! aGMTS;
PICOD M.ISSI; FIEBItS; BBT»BOt«SS
.


Jlndal, S.P.
Vestergaard, P.
1980
Journal of
Pharsaceutical sciences

-------
J.10-Secoc»ol«st»-5.7,10(19)-ttl»»«-3b«ta.2S-aiol (g CI)
«.tO-S«cochel«st«-S,7,10|W)-trie»«-3.2S-diol. (3beta,5Z,7!)- <9 CI)
H3S6-17-3
C27-HM-02
BE •oo.fi';
IISSOI

5270
Blood








1
1
1 5271
I Blood,
plas»









titosns soots aiunicu IQBBSI »»•« »111
RETROD OF CaSIS
b) lot give! b) 32ls nnol/1
c) lot giT« <=) 28.0 MOl/1
4) lot given d) 20.0 n.ol/1
f) lot given f) 29.3 naol/1
I
I 1


a) »t delivery. fro« nothers on
vitaiin supplement
b) Fron control lothets. at aelirery
c) Fro« cora. «ith vitania s«pple»ent
a) Fron cora controls
e) Fro* lnfants-»ith vitanio
:
-------
                                                  509
     5087?-IQ1
     REPORT DOCUMENTATION   i... REPORT NO.
                             EPA 560/5-81-008 A and B
4. Till* and Subtitle
Chemicals Identified in Human  Biological Media,  A Data
Base, Third Annual  Report, October 1981
 2' EIS-163/V3/
_li _and_P2
                                                                                 Accession No.
                                                                           | 5. Report Oat*
     7. Author(i)
    M. Virginia Cone.  Margaret F.  Baldauf, and  Fay M. Martin
    •. Performing Organization Name end Address
    Chemical Effects  Information Center
    Information Center  Complex/Information Division
    Oak Ridge National  Laboratory
    Oak Ridge,  Tennessee  37830
    12. Sponsoring Organization Nam* and Address
    U.S. Environmental Protection Agency
    Office of  Toxic Substances
    Exposure Evaluation Division (TS-798)
    Washington. D.C.  20460	
    IS. Supplementary Notes
                                                                            8. Performing Organization Rept. No.
                                                                       10. Proiect/Task/Work Unit No.
                                                                       11. Contract(C) or Grant(G) No.
                                                                       (O EPA IAG No. 78-D-X383

                                                                       (C)
                                                                       13. Type of Report & Period Covered

                                                                       Annual Report 9/80-9/81
                                                                       14.
   1«- Abstract (Limit: 200 words)
         A comprehensive data base of chemicals  identified in  human biological media
    (tissues and body fluids) has  been established under the direction of the Environmental
    Protection Agency's Office of  Toxic Substances Exposure Evaluation Division.   This
    centralized resource of body-burden information was inspired  by the concern of government
    scientists over continuing reports of toxic chemicals in human  tissues and body fluids.

        Body burden is  a reflection of exposures to  food, air, and water contaminants,
    ae well  as Pharmaceuticals.   The  systematic acquisition of body-burden data will facil-
    itate a more relevant assessment  of human exposure  to toxic chemicals and xenobiotics
    than was  previously  possible using  environmental contamination levels.

        Data  were  obtained primarily from the open literature  through manual  searches of
   selected  journals.  Retrospective searching to 1974 is complete and has yielded over
   3800 pertinent  documents of which approximately 1600  have been entered into  the data
   base as of this report.   These  sources identify over  800 chemicals which  have  been
   found in human  biological media.
  17. Document Analyst!  a. Descriptors

   Body burden
   Human tissues/body fluids
   Residues

    b. Identlflers/Open-Ended Termi
    e. COSATI Field/Group
 18. Availability Statement


  RELEASE TO PUBLIC
                                                     19. Security Class (This Report)
                                                      UNCLASSIFIED
                                                     20. Security Clan (This Page)
                                                      UNCLASSIFIED
                       21. No. of Page*
                         944
                                                                              22. Price
(S**ANSI-Z3».18)
                                     See Instruction! on Reverse
                      OPTIONAL FORM 272 (4-7
                      (Formerly NTiS-35)
                      n«n*rtm*nt o* Commerce
-------
                                     511
                                                         EPA 560/5-81-008B
                                                         ORNL/EIS-163/V3-P2
                           INTERNAL  DISTRIBUTION
      1.   S.  I.  Auerbach
      2.   M.  F.  Baldauf
      3.   M.  V.  Cone
      4.   J.  T.  Ensminger
      5.   W.  Fulkerson
      6.   H.  B.  Gerstner
      7.   F.  M.  Martin
      8.   C.  R.  Richmond
      9.   G.  D.  Robbins
   10.  Biology  Library
11-12.  Central  Research Library
   13.  Document Reference  Section
   14.  ICC Publications Office,  2001
15-24.  ICC Resource Center,  2001
25-26.  Laboratory Records
   27.  Laboratory Records, RC
   28.  ORNL Patent Office
                          EXTERNAL DISTRIBUTION
   29.   Philip L.  Johnson, Executive Director, Oak Ridge Associated
         Universities,  P.O. Box 117, Oak Ridge, Tennessee 37830.
   30.   Office of  Assistant Manager, Energy Research and Development,
         Department of  Energy,  Oak Ridge Operations Office, Oak Ridge,
         Tennessee.
31-57.   Technical  Information  Center,  Department of Energy, Oak Ridge,
         Tennessee  37830.
                                             oU.S. GOVERNMENT PRINTING OFFICE: 1981-546-067/347
-------