United States       OSWER (OS-230)     OERR 9200.6-303 (92-1)
          Environmental Protection  ORD (RD-689)      NTIS No. PB92-921199
          Agency                     March 1992


svEPA    Health Effects Assessment

          Summary Tables



          Annual

          FY 1992

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                                    OHEA ECAO-CIN-821
                                           March 1992
        HEALTH EFFECTS ASSESSMENT

              SUMMARY  TABLES


              FY-1992  Annual
    Office  of Research  and  Development
Office of Emergency and Remedial Response
  U.S.  Environmental Protection Agency
          Washington,  DC  20460

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                            DISCLAIMER


     This  report  has  been  prepared by  the U.S.  Environmental
Protection Agency.  The information contained herein has been taken
from final documents prepared by the Office  of Health and Environ-
mental  Assessment  for the Office  of Solid Waste and  Emergency
Response and the Office of Water, Washington, DC and the Office of
Air Quality  Planning and  Standards,  Research Triangle  Park,  NC.
These documents were reviewed in accordance  with Agency policy and
approved  for  publication.   Mention  of  trade names or commercial
products does not constitute endorsement or recommendation for use.
                                11

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                         TABLE OF CONTENTS

                                                              Page
INTRODUCTION   	     1

WHAT'S NEW IN  THE  ANNUAL FY92 HEAST	     9

USER'S GUIDE:  CHEMICAL TOXICITY AND CARCINOGENICITY   ...     21

USER'S GUIDE:  RADIONUCLIDE CARCINOGENICITY  	  35

HEAST TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)   	    1-1

HEAST TABLE 2:   ALTERNATE METHODS - SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)  	    2-1

HEAST TABLE 3:   CARCINOGENICITY	    3-1

HEAST TABLE 4A:  RADIONUCLIDE CARCINOGENICITY -  SLOPE
FACTORS  (IN PICOCURIES)  	   4A-1

HEAST TABLE 4B:  RADIONUCLIDE CARCINOGENICITY -  SLOPE
FACTORS  (IN BECQUERELS)  	   4B-1

REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC
TOXICITY  (OTHER  THAN CARCINOGENICITY)     	  ....   Rl-1

REFERENCES FOR HEAST TABLE 2:  ALTERNATE METHODS -
SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY) R2-1

REFERENCES FOR HEAST TABLE 3:  CARCINOGENICITY   ......   R3-1

APPENDIX  A:  TECHNICAL INFORMATION   	 A-l
                                111

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                           INTRODUCTION








     This document is the FY92  annual update of the Health Effects



Assessment  Summary  Tables  (HEAST)  prepared by  EPA's  Office  of



Health and  Environmental Assessment,  Environmental  Criteria and



Assessment Office, Cincinnati,  OH for use at both  Superfund and



RCRA sites.   It completely  replaces  all former editions  of the



HEAST.



     The  HEAST  is   a comprehensive  listing  consisting  almost



entirely of  PROVISIONAL  RISK ASSESSMENT  INFORMATION relative  to



oral and inhalation  routes for  chemicals  of interest to Superfund,



the Resource Conservation and Recovery Act (RCRA),  and the EPA in



general.  These entries in the  HEAST are  limited to chemicals that



have undergone review and have the concurrence of individual Agency



Program Offices,  and each  is  supported  by an Agency reference.



This risk  assessment  information has not,  however,  had  enough



review to  be recognized  as high quality, Agency-wide consensus



information.



     The Integrated  Risk  Information System (IRIS) is the Agency's



official repository of Agency-wide consensus chronic human health



risk information.  IRIS evaluations are conducted by the Agency's



Work Group Review process,  i.e.,  they have been examined by either



the Reference Dose/Reference Concentration (RfD/RfC)  Work Group or



the Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work



Group.   These Agency  Work  Groups conduct a process  that leads to



internal Agency scientific  consensus  regarding risk  assessment



information on a chemical.  This information is recorded on IRIS,

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is considered to be  "Work Group Verified", and does not appear on

the HEAST.   Thus,  provisional risk assessment information on the

HEAST is  subject  to  possible review and revision by these Agency

Work Groups.

     There are two exceptions to the above discussion.  The HEAST

also  contains  information  on chemicals that  are  a part  of the

National  Ambient  Air  Quality Standards (NAAQS)  or  the Drinking

Water Criteria Document (DWCD) series.  In each of these cases, the

chemicals are subject to extensive scientific peer review processes

of extremely high quality.



CHEMICAL STATUS DEFINITIONS

     Chemicals reviewed by  the Agency  Work Groups are classified

according to their status as  either "verified", "not verifiable",

or "under review".   The toxicity values  (other than NAAQS or DWCD

values)  listed  on the  HEAST  are considered  to be "provisional".

The Agency  has  no official definitions  for  these  terms,  but the

HEAST user may interpret them as follows:


     Provisional:    A  toxicity value  or a cancer  value  is
     "provisional" if  the value  has had some form of Agency
     review, but it does not appear on the IRIS system.  These
     values  are generated  in several  ways.   Often they are
     determined in the course  of developing an Agency document
     on a chemical or on a class of chemicals.   Some have been
     generated through the  Work  Group  process, but have not
     yet  been  input to the  IRIS  system.  At  the  time each
     value  was  derived,  all  available  information  on  the
     chemical was  evaluated,  the  value was calculated using
     the most current methodology, and a consensus was reached
     on the value by Agency scientists.

     These "provisional" values are found on  the HEAST.  They
     do not appear on  IRIS.
                               -2-

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     Verified:   A toxicity value or a cancer value is  "Work
     Group Verified" if all available information on the  value
     has  been examined by an Agency Work Group,  the value has
     been calculated using current Work Group methodology, and
     a  unanimous consensus has been reached on the value by
     the  Work Group.

     These values have been, or shortly will be added to  IRIS.
     Some "verified" numbers may appear  on the HEAST  for a
     short time until  they are loaded onto  IRIS.   During the
     interim, they are considered to be "provisional" values.

     Not  verifiable:  A toxicity value is "not verifiable" if
     an Agency Work Group has considered all available data on
     a  chemical and has  unanimously determined  that data are
     inadequate to generate a value  that would be suitable for
     inclusion  on IRIS.   No toxicity value  is calculated.

     No toxicity values  are available for IRIS  or  the HEAST.
     This "not  verifiable"  status,  however,  has been,  or
     shortly will be noted  on IRIS, and is often found on the
     HEAST,  with a  pointer to the IRIS  system.

     Under Review:   A  toxicity value  is  "under review"  if an
     Agency  Work Group is  in the process of  considering all
     available  data on a chemical.  No  conclusions have been
     drawn thus far by the Work Group.   Toxicity values that
     have been  withdrawn from IRIS  by a  Work Group will have
     this status.

     This status may be  indicated  on  IRIS  or  on  the HEAST.
     During  this time,  "provisional"  toxicity  values  may
     appear  on  the HEAST.

     In all  cases, the status of a chemical  may  change as  new data

become available, and  the assessment  is revisited.
CAUTION

     It is imperative for each user of the HEAST to recognize that

the values listed in the toxicity tables and the cancer table are

generally considered to be PROVISIONAL RISK ASSESSMENT INFORMATION.

The user is referred to  IRIS  for  "Work Group Verified" values.  It

is also  important to remember that  the numbers in  these tables

alone tell very little about the adverse effects of a chemical or


                               -3-

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the quality  of evidence on which  risk  assessment information is

based.  Original assessment documents must be consulted by users of

the HEAST  in  order to fully  appreciate  the strengths and limita-

tions  of  a specific  data  base.    Original  source documents will

allow for the most complete characterization of potential toxicity

associated with the range of  exposure pathways generally evaluated

at Superfund and RCRA sites.  The  Reference Tables point the user

to these sources.



CONTRIBUTORS
                                               •
     Chemicals  commonly  found  at  RCRA  sites as identified by the

Office  of Solid  Waste's  (OSW)  Technical  Assessment Branch are

included  in  the  HEAST.    The  Office  of Radiation  Programs has

provided data on radionuclide carcinogenicity for  Tables 4A and 4B

of the HEAST.   Finally,  the Office of  Air Quality  Planning and

Standards  (OAQPS)  has provided information on chemicals for which

Air Quality  Criteria Documents and National  Ambient Air Quality

Standards have  been developed.



CHEMICALS LISTED

     Most  of  the  chemicals  included  on the  toxicity tables and

carcinogenicity table are those  for which  at least one  of the

following EPA documents  has been written:  Health Effects Assess-

ment  Document  (HEA),  Health  and  Environmental  Effects  Profile

(HEEP), Health  and Environmental  Effects Document (HEED), Health

Assessment Document  (HAD), Air Quality Criteria Document (AQCD),

Drinking Water  Criteria Document (DWCD).  A description of each is


                               -4-

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provided in Appendix .A,  Section I.   In a few cases, the values are

supported by other  written material,  such as Work  Group meeting

notes or Carcinogen Assessment Group (CAG)  Profiles.  Radionuclides

included are those  believed to  be most  commonly encountered at

Superfund sites.

     The  names  of  criteria  pollutants  that  are  regulated  as

National Ambient Air Quality Standards  (NAAQS) under the Clean Air

Act  are listed  in  the  main body  of the HEAST,  but  the actual

criteria  are  included  as  Section V  of  Appendix  A:  Technical

Information. The NAAQS were not included in the  tables  in  order to

distinguish them from the reference concentration ([RfC]) values.
                                        *
The  NAAQS  and  [RfC]s  represent different  levels of  review and

different methods of calculation and thus, must  be interpreted and

used differently.



HIERARCHY OF SOURCES

     It  is recognized  that  at  any point in  time  there may be

multiple old and new Agency  documents  or  data bases that present

different values on a specific  chemical.   For chemicals other than

those represented by the NAAQS or DWCDs,  the following hierarchy of

sources  is  recommended  in  evaluating  chemical  toxicity  for

Superfund sites:


      1. The Agency's Integrated Risk Information System (IRIS) and
         cited references.  Changes are made in this data base on
         a monthly  basis,  but  there may be data gaps.   Call IRIS
         USER  SUPPORT at  513/569-7254  (FTS 684-7254)  for further
         information.

     2.  The Health Effects Assessment Summary  Tables  (HEAST) and
         cited references.
                               -5-

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     3.  Consultation  with the  Superfund Health  Risk Technical
         Support Center  (TSC) at  (513)569-7300; FTS 684-7300.

     4.  Do not consult either the toxicity tables  (Appendix A) in
         the Superfund Public Health Evaluation Manual  (SPHEM, U.S.
         EPA,  1986)   or  the  September  1988  Public  Health  Risk
         Evaluation Data Base  (PHRED) as these sources are likely
         to contain numerous values that have  since become out-of-
         date.
QUESTIONS

     Chemical Toxicity and Carcinogenicity

     Regional EPA  Superfund  Staff may direct questions regarding

the contents of the chemical toxicity and carcinogenicity tables on

the HEAST  (e.g.,  chemicals  not covered, chemicals  with  pending

[RfD]s) to  EPA's Superfund Health  Risk Technical Support Center

(TSC)   in  Cincinnati,  OH  at   (513)   569-7300   (FTS   684-7300).

Questions from other users must be submitted to  the TSC  in writing

and must contain the following  information:

     -     Superfund site name,  site  location and twelve-digit
           site number;

     -     Name and phone number of the site Remedial Project
           Manager (RPM) or Regional  Risk Assessor/Toxicologist;

     -     Detailed description of the  risk assessment  related
           question.

     Please send requests via mail or FAX to:

     Superfund Health Risk Technical  Support Center
     US EPA
     26 W. ML King Dr.
     Environmental Criteria and Assessment Office
     MS 114
     Cincinnati,   OH  45268
     FAX#:    (513) 569-7159
                                -6-

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     RCRA Chemicals



     Questions about RCRA chemicals may be addressed by calling the



Health Assessment Section  of  the Office of Solid Waste  at (202)



260-4761 (FTS 260-4761).



     Radionuclide Carcinogenicity



     Questions concerning radionuclide carcinogenicity should first



be  addressed by  contacting the  appropriate Regional  Radiation



Program Manager.   A listing of these managers and several contacts



in the  Office  of Radiation Programs  can be found in  the User's



Guide - Radionuclide Carcinogenicity on pages 46-48.








REFERENCES



     Most cited Agency references (e.g., HEAs,  HEEPs, HEEDs),  are



(or  will  soon  be)   available   through  the  National  Technical



Information Service (NTIS), 5285 Port Royal Road, Springfield, VA



22161 (703/487-4650 or 800/336-4700).  Carcinogen Assessment Group



(CAG) Profiles cited  in Table  3 are available  through  the  RCRA



docket  (202/260-9327).








ORDERING INFORMATION



     Limited copies of the HEAST are available  for EPA Superfund



staff, State Superfund programs  and other Federal agencies working



on Superfund sites,  and  EPA contractors working for the EPA Super-



fund program.  Users  in these groups can  call  Syracuse Research



Corporation  (703) 769-1880 to be put on the mailing list.



     EPA's Office of  Solid Waste (OSW)  requests  that their users



(i.e., OSW staff,  contractors, State solid waste programs)  call the






                               -7-

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Health Assessment Section  (202) 260-4761 (FTS 260-4761) to obtain

copies of the HEAST.  Regional OSW staff are reminded that copies

are sent to all EPA Regional libraries.

     Users of the HEAST in EPA's  Office of Air and Radiation and

State air programs should call Rick Mattick of EPA's Office of Air

Quality Planning and Standards at  (919) 541-3990.

     All other users must  purchase the document from:

         National Technical Information Service (NTIS)
         5285 Port Royal Road
         Springfield, VA   22161
         (703) 487-4630

     For  ordering   information,   call  the  NTIS  Subscriptions

Department at (703)487-4630.  NTIS normally ships 4th class United

States  mail.    Therefore,  users  may wish  to  consult  with  NTIS

concerning the  use of  an  overnight  delivery service.   The  NTIS

order number is PB92-921100.
                               -8-

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                  WHAT'S NEW IN THE FY92 HEAST



GENERAL CHANGES - CHEMICAL TOXICITY AND CARCINOGENICITY

     Several  changes  in  presentation,  information,  and  data

availability have been made since  the  FY91  version  of the HEAST.

The most significant change is that IRIS values will no longer be

found in the HEAST.   Instead of listing the IRIS values associated

with a given chemical, these tables will direct the user to IRIS

for that  information.   This  modification is in keeping, with the

policy of the Office of Emergency and Remedial Response that risk

assessors consult IRIS as their first source for toxicity values.

     The changes in  this version of the HEAST  reflect changes in

IRIS through January 1,  1992.  It is also current with RfD/RfC and

CRAVE Work Group activities through this same date.

     The information contained in each table  and  their designations

have been changed as follows:

     HEAST TABLE 1:   SUBCHRONIC  AND  CHRONIC TOXICITY (OTHER
     THAN CARCINOGENICITY)
     Table 1, formerly Table A,  lists subchronic and chronic
     non-cancer toxicity values that were calculated  using the
     current methodology practiced  by the RfD/RfC Work Group.

     HEAST TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND
     CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
     Table 2 is a new table that lists subchronic and chronic
     non-cancer  toxicity  values that  are  found in  Agency
     documents,  but  were  calculated by  alternative methods
     that are  not currently practiced by the  RfD/RfC Work
     Group.    These  values are  considered  to be  adequate
     provisional  values  for  risk assessment  purposes  at
     Superfund  and  RCRA  sites,  but  are  subject  to being
     reviewed  by the RfD/RfC  Work Group  and  revised when
     necessary to reflect current work group practices.

     HEAST TABLE 3:  CARCINOGENICITY
     Table 3, formerly Table B,  lists carcinogenicity values
     that were calculated using the current methodology of the
     CRAVE Work Group.

                               -9-

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     HEAST TABLES 4A AND 4B:  RADIONUCLIDE CARCINOGENICITY -
     SLOPE FACTORS
     Tables  4A and  4B, formerly  Table C,  list ingestion,
     inhalation and  external exposure carcinogenicity slope
     factors for radionuclides in two equivalent, but differ-
     ent units, picocuries and becquerels, respectively.

     HEAST  TABLE  1  REFERENCES:    SUBCHRONIC  AND  CHRONIC
     TOXICITY  (OTHER THAN CARCINOGENICITY)
     The references for Table 1  are  now numerically coded to
     associate  each  toxicity value  clearly  with its corre-
     sponding reference.

     HEAST TABLE 2 REFERENCES:  ALTERNATE METHODS - SUBCHRONIC
     AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
     The references for Table 2  are  now numerically coded to
     associate  each  toxicity value  clearly  with its corre-
     sponding reference.

     HEAST TABLE 3 REFERENCES:   CARCINOGENICITY
     The references for Table 3  are  now numerically coded to
     associate  each  toxicity value  clearly  with its corre-
     sponding reference.

     The format of Tables 1,  2 and 3  has been changed to allow for

the  inclusion of more information.    Enhancements of  the HEAST

include  the  addition  of  the Chemical  Abstract Service Registry

Number  (CASRN)  for each chemical,  the identification of the dose

level (e.g.,  NOAEL, meaning "No-Observed-Adverse-Effect Level") on

which the  toxicity  value is based,  the identification  of target

organs,  and  a description  of  the critical  effects  and cancers.

Additionally, footnotes at the end  of the tables have been replaced

by presenting  relevant information regarding a specific toxicity

value in the comment section after each chemical entry.

     The nomenclature  has  also  changed.   Brackets are now placed

around the names of toxicity and carcinogenicity values to distin-

guish these  "provisional"  values  from  information on  IRIS.   The

following names are  affected:   RfD to [RfD], RfC to [RfC], slope
                               -10-

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factor to [slope  factor], EPA group to [EPA Group] and unit risk to

[unit risk].

     Finally, a  technical appendix  (Appendix A)  has  also  been

developed with the  following  sections  available  for information:

I.    Data Sources and Selection Criteria Used in HEAST

II.   Dose Conversions on HEAST

III.  Chemical Name and Chemical Abstracts Service
      Registry Number Cross Reference

IV.   Effect Level Definitions

V.    National Ambient Air Quality Standards (NAAQS)

CHEMICAL-SPECIFIC CHANGES - CHEMICAL TOXICITY AND CARCINOGENICITY

    The major  chemical-specific  changes  that have occurred  on

Tables 1,  2  and  3 since  the FY91  HEAST are listed  below.   Due to

the large  extent  of modifications,  consistency changes that were

made  in  these  tables are  not detailed  in this  section.   For

example,   modifications  on  the description  of the administered

doses, critical  effects,  critical studies,  and effect levels are

not discussed.

    Recent activity by  the  RfD/RfC  and  CRAVE  Work  Groups has

changed the status of several  chemicals in Tables 1, 2  and  3.  For

chemicals  that  are  currently  under review by  the  Work Groups,   a

comment simply  indicates that the toxicity value  is under review

and may be subject  to change.
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A.  CHEMICAL-SPECIFIC CHANGES ON  HEAST TABLE 1:   SUBCHRONIC AND
CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)

1.  Additional Chemicals listed on Table 1

    Boron trifluoride                 Carbon monoxide
    Formaldehyde                      Heptachlor epoxide
    Phorate                           Selenium
    Strontium, stable                 Sulfur dioxide
    Tetrachloroethane, 1,1,1,2-       Warfarin

2.  Chemicals that were  considered to be Not Verifiable  for the
    Chronic Inhalation RfC by the RfD/RfC Work Group

    Acrylamide                        Benzidine
    Biphenyl, 1,1-                    Carbaryl
    Cresol,  m-                        Cresol, o-
    Cresol,  p-                        Dinitrophenol, 2,4-
    Ethylene diamine                  Hexachloroethane
    Isophorone                        Methyl isocyanate
    Phenol                            Propylene  glycol
    Propylene glycol monoethyl ether  Trichlorophenol, 2,4,5-
    Trichlorophenol,  2,4,6-           Xylene, m-
    Xylene,  mixture                   Xylene, o-
    Xylene,  p-

3.  Chemicals that were  withdrawn from IRIS by  the RfD/RfC Work
    Group (provisional values remain on Table 1)

    Barium cyanide                    Cresol, p-
    Formic acid                       Methyl ethyl ketone
    Methyl isobutyl ketone            Selenourea
    Simazine                          Trichloroethane, 1,1,1-
    Trichlorobenzene,1,2,4-

4 .  Chemicals listed in the National Ambient Air Quality Standards
    (NAAOS)  (Appendix A)

    Carbon monoxide
    Lead  (and Lead compounds)
    Nitrogen dioxide (Nitrogen oxide,  Nitric oxide)
    Ozone
    Particulate matter
    Sulfur dioxide (Sulfur oxide)

5.  Chemicals that are also  listed in Table 2:  Alternate Methods -
    Subchronic and Chronic Toxicitv (Other Than  Carcinogenicity)

    Acetone cyanohydrin               Acetonitrile
    Acetophenone                      Barium
    Chloro-1,3-butadiene              Chlorobenzene
    Cyclopentadiene                   Dichlorobenzene, 1,2-
    Dichlorodifluoromethane           Dichloroethane, 1,1-
    Dicyclopentadiene                 Ethoxyethanol acetate,2-

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   Ethylene diamine                   Furfural
   Methacrylonitrile                  Methoxyethanol  acetate,  2-
   Methyl acrylate                    Methyl  ethyl  ketone
   Methyl isobutyl ketone             Methyl  styrene,  alpha-
   Methyl styrene  (mixed isomers)     Methylene  bromide
   Nitrobenzene                       Trichlorobenzene,  1,2,4-
   Trichloroethane, 1,1,1-            Trichlorofluoromethane

6.  Additional Changes in Table 1 include:

   Acetone cyanohvdrin
   The chronic  [RfC] value was moved  to  Table 2.   (See  section B
   below.)

   Acrolein
   The subchronic  and  chronic oral [RfD]s were added to  reflect
   the 1985 KEEP.  The subchronic inhalation [RfC]  was changed to
   reflect the recently verified chronic RfC on IRIS.

   Aldicarb
   The subchronic oral [RfD]  was changed to reflect the conversion
   from the recently verified chronic RfD on IRIS.

   Ammonia
   The  subchronic inhalation  [RfC]  was changed  to  reflect  the
   recently verified chronic RfC on IRIS.

   Arsenic, inorganic
   The subchronic  oral  [RfD]  was changed to  reflect the adoption
   of the recently verified chronic RfD  on IRIS.

   Barium
   The subchronic oral [RfD] was added to reflect the adoption of
   the recently verified chronic oral RfD on IRIS.

   Barium cyanide
   The subchronic  and chronic oral  [RfD] values reflect the  1985
   Drinking Water  Criteria Document.  The  chronic  oral  [RfD]  was
   withdrawn from  IRIS.

   Benzyl alcohol
   The  uncertainty  factor  for  the  subchronic oral  [RfD]   was
   changed to reflect the 1989 HEED.  The [RfD]  value remains the
   same.

   Boron
   The  subchronic and  chronic  inhalation  [RfC]s  were added to
   reflect the  1991 HEED.

   Bromomethane
   The chronic  inhalation  [RfC] was  changed  to  reflect  the value
   under review by the RfD/RfC Work Group  (1991).
                              -13-

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Captan
Expression of the subchronic oral  [RfD] was changed from one to
two  significant digits  to  reflect  the presentation  of the
chronic RfD on IRIS.

Chlorophenol. 2-
The  subchronic  oral  [RfD]  and  its uncertainty  factor  were
changed because an uncertainty  factor  of 10  given  for  sub-
chronic to chronic conversion was removed.

Chloropropane. 2-
The chronic  and subchronic inhalation [RfC]s were changed to
reflect the 1987 HEED.

Chromium(III)
The inhalation  [RfC]s were removed pending resolution of the
Agency's  position.    The  subchronic [RfD] was  changed to be
consistent with information on IRIS.

Chromium(VI)
The inhalation  [RfC]s were removed pending resolution of the
Agency's position.

Dichloropropane. 1.2-
The  subchronic   inhalation  [RfC]  was  added  to  reflect the
conversion from the recently verified chronic RfC on IRIS.

Diethylformamide
The chronic and subchronic oral [RfD]s were changed to  reflect
the 1986 KEEP.

Dimethyl phthalate
The chronic  and subchronic oral  [RfD] values were changed to
reflect the  1987 HEEP.  These  values are  also  under review by
the Work Group.

Endosulfan
The subchronic oral  [RfD]  was  changed to  reflect  the adoption
of the chronic RfD on IRIS.

Endrin
The subchronic oral  [RfD]  was  changed to  reflect  the adoption
of the chronic RfD on IRIS.

Epichlorohydrin
The subchronic oral  [RfD]  was  changed to  reflect  the adoption
of the chronic RfD on IRIS.  The  chronic  inhalation [RfC] was
changed to reflect the value under  review  by the  RfD/RfC Work
Group (1991).

Ethoxyethanol. 2-
The subchronic  inhalation  [RfC] was changed because an uncer-
tainty factor of  10  for subchronic to chronic  conversion was
removed.

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Ethyl ether
The subchronic oral  [RfD] was changed to reflect the conversion
from the recently verified chronic RfD on IRIS.

Ethylene thiourea
The subchronic  oral  [RfD]  was added  to reflect the  recently
verified chronic RfD on IRIS.

Lead
The user is asked to refer to IRIS.

Lead alkyls
The oral  [RfD]  values  were removed and  the  user is  asked  to
refer to IRIS.

Malononitrile
The uncertainty factor for the chronic oral  [RfD] was changed
to reflect the 1986 KEEP.  The [RfD] value remains the same.

Methomyl
Expression of the subchronic  oral  [RfD] was changed from one  to
two  significant digits  to reflect  the presentation of the
chronic RfD on IRIS.

Methylcyclohexane
The  subchronic  and chronic  inhalation  [RfC]s  were   added  to
reflect the 1991 HEED.

Methylenediphenyl isocyanate, 4.4'-
The chronic inhalation [RfC] was  changed to  reflect  the  value
under review by the RfC/RfD Work  Group (1990).   The subchronic
[RfC] was adopted from the chronic [RfC].

Molybdenum
The  chronic  oral  [RfD]  and the  subchronic oral  [RfD]  were
changed to reflect the value under review by the RfD/RfC Work
Group (1991).

Naphthalene
The chronic oral [RfD] was  changed to reflect the evaluation  by
the  RfD/RfC  Work Group  (1989).    For the  chronic   [RfD],  an
uncertainty factor of 1000 represents  10 each for intraspecies
and  interspecies  extrapolation and cataract  formation.   The
subchronic [RfD] was adopted from the chronic  [RfD].

Nitroaniline. o-
The oral and inhalation values were added to reflect the 1991
HEED.

Nitrobenzene
The subchronic and chronic [RfC]s were moved to Table 2.   (See
section B below.)
                           -15-

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Phenylenediamine, p-
The chronic oral  [RfD] was added to reflect the 1985 KEEP.

Phosphine
The uncertainty factors for the subchronic and chronic  inhala-
tion  [RfC]s were  changed  to  reflect the  1989  HEED.  The  [RfC]
values remain the same.

Profluralin
The uncertainty  factors  for the  subchronic  and chronic  oral
[RfD]s were changed to reflect  the 1984 HEEP.   The [RfD] values
remain the same.

Pronamide
Expression of the subchronic  oral  [RfD] was changed from one to
two  significant  digits  to  reflect  the  presentation  of the
chronic RfD on IRIS.

Propylene glycol monmomethyl ether
The  subchronic  inhalation [RfC]  was changed  to reflect the
conversion from the recently verified chronic RfC on IRIS.

Selenious acid
The subchronic oral  [RfD] was  changed to reflect the recently
verified chronic RfD on IRIS.

Silver
The subchronic  oral  [RfD] was  changed to reflect adoption of
the recently verified chronic RfD on IRIS.

Terbufos
The subchronic and chronic oral  [RfD] were changed  to  reflect
the 1987 HAD.

Thallium (in soluble salts)
The oral [RfD]  values were removed from Table 2 and the  user is
asked to refer to IRIS for other thallium salts.

Thiram
The chronic oral  RfD reflects  input on  IRIS.   The  subchronic
oral  [RfD] reflects the 1989 HEED.

Toluene
The chronic inhalation  [RfC] was changed to  reflect the  value
under review by the RfD/RfC Work Group.

Trichloro-1.2.2-trifluoroethane. 1.1,2-
The  chronic  RfD  reflects IRIS input.   The  subchronic  [RfD]
value was from a recent source document, the 1990 HEED.

Trichlorobenzene. 1,2,4-
The subchronic  and chronic  oral  [RfD]  values  reflect recent
evaluation by the Work Group (1991).   The chronic oral  RfD was
withdrawn from IRIS.

                           -16-

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B.  CHEMICAL-SPECIFIC  CHANGES  ON  HEAST  TABLE  2:    ALTERNATIVE
    METHODS  - SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER  THAN
     CARCINOGENICITY)
1.
Chemicals with values moved from Table 1.
    Table  2  was created to list subchronic and chronic non-cancer
toxicity  values that  are found  in Agency  documents,  but  were
calculated by alternative methods  that are not currently practiced
by  the  RfD/RfC Work Group.   These values  are considered  to be
adequate  provisional  values  for  risk  assessment  purposes  for
Superfund and RCRA sites, but  are  subject to being reviewed by the
RfD/RfC Work Group and revised  when necessary to reflect current
work group  practices.    The  following  chemicals had  values that
could be categorized as such,  and these were moved to Table 2.
    Acetone  cyanohydrin
    Acetophenone
    Chloro-1,3-butadiene
    Cyclopentadiene
    Dichlorodi fluoromethane
    Dicyclopentadiene
    Ethylene diamine
    Methacrylonitrile
    Methyl aerylate
    Methyl isobutyl ketone
    Methyl styrene (mixed isomers)
    Nitrobenzene
    Trichloroethane,  1,1,1-
                               Acetonitrile
                               Barium
                               Chlorobenzene
                               Dichlorobenzene,  1,2-
                               Dichloroethane,  1,1-
                               Ethoxyethanol acetate,2-
                               Furfural
                               Methoxyethanol  acetate,  2-
                               Methyl ethyl ketone
                               Methyl styrene,  alpha- .
                               Methylene bromide
                               Trichlorobenzene,  1,2,4-
                               Trichlorofluoromethane
2.  Additional  Changes in Table 2  include:

    Acetone cyanohydrin
    The chronic inhalation  [RfC]  was changed  because  the uncer-
    tainty factor  in the  1988 HEED document was incorrectly cited.
    An uncertainty factor of 10 was added for  subchronic to chronic
    conversion.  The value was  formerly  listed in Table  1.

    Nitrobenzene
    The uncertainty factors for the subchronic and chronic inhala-
    tion [RfC]s were changed to reflect  the  1987 HEA.   The  [RfC]
    values remain the  same.   The values were  formerly  listed in
    Table 1.
C.  CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 3:

1.  Additional Chemicals Listed on Table 3

    Ethylnitrosourea
    Hexachlorocyclohexane,  delta-
    Hexachlorocyclohexane,  epsilon-
    Methylnitrosourea
                                            CARCINOGENICITY
                               -17-

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Additional Changes to Table 3 include;

Alachlor
The oral  [slope  factor] was changed  to  reflect  the  evaluation
by the CRAVE Work Group (1988).

Benzo[a]pyrene
The oral  [slope  factor]  and [unit risk] was added  to  reflect
the values under review by the CRAVE Work Group (1991).

Bisf2-Chloroisopropyl) ether
The inhalation [slope factor] and  [unit risk] were  changed  to
reflect a 50% absorption factor  for the conversion from the
oral [slope factor].

Bromoethene
The inhalation [unit risk] was changed  to  reflect the  conver-
sion from the inhalation  [slope factor].

Carbazole
The oral [unit risk]  was changed to reflect conversion from the
oral [slope factor].

Carbon Tetrachloride
The  inhalation   [slope factor]  was changed  to  reflect a 40%
absorption  factor for  the conversion  from the  oral  [slope
factor].

Chloronitrobenzene. o-
The oral [unit risk]  was changed to reflect the conversion from
the oral  [slope  factor].

Chrysene
A footnote was  added to refer the reader to the RCRA  program
for numeric risk assessments  for RCRA activities.

Dibromo-3-chloropropane.  1.2-
The oral and inhalation [slope factor]s and [unit risk] values
were changed  to  reflect values under review by  the  CRAVE Work
Group  (1990).  The oral values were also cited in the Drinking
Water Criteria Document (1989).

1.1-Dimethylhydrazine
The oral and inhalation [slope factor] and [unit risk]  values,
as well as the cancer [EPA group]  classification,  were  changed
to reflect values under review by the CRAVE Work Group  (1988).

1.2-Dimethylhydra2ine
The oral and inhalation [slope factor] and [unit risk]  values,
as well as the cancer [EPA group]  classification,  were  changed
to reflect values under review by the CRAVE Work Group  (1990).

Direct Black  38
The oral  [slope  factor] was changed  to  reflect  the  1987 KEEP.

                           -18-

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Direct Blue 6
The oral [slope factor] was changed to reflect the 1987 KEEP.

Ethylene Oxide
The oral [slope factor] and [unit risk] were added to  reflect
the 1984 HEEP.

Ethylene thiourea
The oral [slope factor] and [unit risk] were changed to  reflect
the recent OPP evaluation of newer data.

Furium
The oral [unit risk] was changed to reflect the conversion from
the oral [slope factor].

Methvlaniline hvdrochloride.  2-
The oral [unit risk] was changed to reflect conversion from the
oral [slope factor].

Propylene oxide
An inhalation  [slope factor]  was added.

Styrene
The quantitative  risk  assessment values were  removed  pending
resolution of  the Agency's position.   Contact the  Superfund
Health Risk Technical Support Center for more  information (see
page 6).

Tetrachloroethylene
The quantitative  risk  assessment values were  removed  pending
resolution of  the Agency's position.   Contact the  Superfund
Health Risk Technical Support Center for more  information (see
page 6).

Toluidine. p-
The oral [unit risk] was changed to reflect conversion from the
oral [slope factor].

Trichloroethylene
The quantitative  risk  assessment values were  removed  pending
resolution of  the Agency's position.   Contact the  Superfund
Health Risk Technical Support Center for more  information (see
page 6).

Vinvl Chloride
The inhalation  [slope  factor] was added to reflect conversion
from the inhalation [unit risk].
                           -19-

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D.  CHANGES ON  HEAST TABLES  4A AND  4B:    RADIONUCLIDE CARCINO-
    GENICITY - SLOPE FACTORS

1.  Ingestion, inhalation and external exposure slope factors for
    radionuclides,   formerly  reported  in HEAST  Table C,  are now
    listed in the new HEAST Tables  4A  (in customary activity units
    of picocuries (pCi))  and 4B (in the International System (SI)
    activity units of becquerels (Bq)).

2.  Radionuclide  data have  been   rearranged  alphabetically  by
    element for easier reference.

3.  Over 200 new radionuclides  have been added  to provide a more
    comprehensive data set for risk calculations.

4.  Additional guidance and slope factor values have been included
    for important decay chain radionuclides: A radionuclide marked
    with the  suffix "+D"  in Tables 4A and  4B  indicates that its
    inhalation,   ingestion  and  external exposure slope  factors
    include the  added risks from associated  radioactive decay chain
    products in  equilibrium with  the parent in  the environment.
    (Slope factors for all radionuclides always account for decay
    products created within the body after  intake.)

5.  A Chemical Abstract Service Reference Number  (CASRN) has been
    assigned to  each radionuclide for identification and reporting
    accuracy..

6.  Radioactive half-lives have been added  for  reference.

7.  Pathway specific unit  risk values are no  longer  reported.
    Instead, a list of EPA documents that provide guidance on the
    use of slope factors  in radiation risk assessment calculations
    has been included in  the User's Guide.

8.  Slope factors for external  exposure to radionuclides in soil
    have been recalculated.  New values are expressed in terms of
    lifetime cancer incidence risk per unit exposure to a source of
    uniform activity per  unit  mass in  soil  (e.g.,  risk/yr per
    pCi/g), assuming a thick layer  of uniformly contaminated soil.
    [The previous slope factors were  for exposure to a source of
    uniform activity per  unit surface  area.]

9.  Slope factors for inhalation and ingestion have been  revised to
    be consistent  with  recent  EPA Science Advisory  Board  (SAB)
    recommendations for the regulation of radionuclides in drinking
    water.   These changes, which primarily  affect alpha-emitters,
    include a  reduction in the GI absorption  factor (f^) for uranium
    radionuclides from 0.2 to 0.05; incorporation of sinus carci-
    nomas in  Ra-226 risk estimates; adjustment  in  the  doses and
    resultant risks of bone cancer  and leukemia risk for Ra-228; a
    reduction in  the leukemia  risk from  alpha  radiation;  and a
    recalculation of the urinary system cancer risk based on both
    the dose to the kidneys and the urinary bladder.

                               -20-

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                USER'S GUIDE:  CHEMICAL TOXICITY







     The  Health  Effects  Assessment  Summary  Table  summarizes



provisional toxicity and  cancer values as well as values developed



for the NAAQS and DWCD chemicals.   The provisional  status of the



toxicity and cancer  values  is indicated by placing brackets around



the  title  of  the  value.   These  include provisional  reference



concentrations ([RfC])  and  provisional reference doses ([RfD]) for



toxicity from subchronic and chronic inhalation and oral exposure



(Tables 1 and 2) and provisional  slope  factors ([slope factor]),



provisional cancer  classifications  ([EPA  Group])  and provisional



unit  risk  values  ([unit  risk])  for  carcinogenicity,  based  on



lifetime inhalation and oral exposure (Table 3).  Brackets should



be included with the acronym whenever a user quotes the value in an



assessment document, and  the provisional nature of  the value should



be noted.  A more complete discussion of how Superfund develops and



considers the toxicity  assessment  in hazardous  waste sites  is



presented in Chapter 7 of Risk Assessment Guidance for Superfund:



Human Health Evaluation Manual,  Part A.



     The references listed  for  each chemical  in  the  Reference



Tables for Tables 1, 2 and 3 represent  the study  or studies that



are the basis for the [RfC], [RfD], [slope factor],  [EPA Group], or



[unit risk], as well as the EPA reference that is the source of the



Agency analysis or  risk  assessment information.   In  some cases,



additional EPA documents  are also listed as a source  of information



on the chemical.  Work Group verified values  found on IRIS are not
                               -21-

-------
found on the  HEAST,  but are indicated  in  the  tables by the word

"IRIS" in place of the number.

     The following documents cited in this  section may be obtained

from their respective sources:


     From  the  Center  for  Environmental  Research  Information
     (513)569-7562.

      Risk  Assessment  Guidance:  Volume  1,   Human  Health
      Evaluation Manual, Part A.  EPA/540/1-89/002.

      Air Quality Criteria Documents.

     From  the  National  Technical   Information  Service   (NTIS)
     (703)487-4780.

      Interim Methods for Development of Inhalation Reference
      Doses.  EPA/600/8-88/006F.  Order number PB90-145723.
      The price is $31.00.
TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINO-
          GENICITY)

     The [RfC] or [RfD]  is a provisional estimate (with uncertainty

spanning perhaps  an order  of magnitude)  of the daily exposure to

the human population (including sensitive subgroups) that is likely

to be without an  appreciable  risk of deleterious effects during a

portion  of  the lifetime,  in the case of a  subchronic [RfC]  or

[RfD] ,  or  during a  lifetime,  in  the case of  a chronic [RfC]  or

[RfD].  The [RfC] and [RfD] values are listed in Tables  1 and 2 in

columns  with  the  headings   "Subchronic11  and  "Chronic".     The

critical  dose or  concentration  level is  usually  a No-Observed-

Adverse-Effect  Level (NOAEL)  or a Lowest-Observed-Adverse-Effect

Level  (LOAEL)  (See Appendix  A, Section  IV:  Effect Level Defini-

tions,  for  more information)  .  The  [RfC]  or [RfD] is derived by
                               -22-

-------
dividing the NOAEL or LOAEL by an uncertainty factor  (UF) times a

modifying factor (MF):

                 [RfC] or  [RfD] = NOAEL or LOAEL
                                      UF x MF
In Tables 1 and 2, the information listed is the following:
Chemical
Level
Dose
Route
Species
Experiment Length
Target
Critical Effect
Subchronic [RfC]

UF

Subchronic [RfD]
UF

Chronic [RfC]
UF

Chronic [RfD]
UF

Reference
= Chemical Name/CASRN
= Effect Level
= Administered Dose or Concentration
= Route of Administration
= Tested Species
= Length of Exposure
= Target Organ(s) Affected at Critical Level
= Effect(s) Observed at Critical Level
= Subchronic Inhalation [Reference Concen
  tration]
= Uncertainty Factor for the Subchronic
  Inhalation [Reference Concentration]
= Subchronic Oral [Reference Dose]
= Uncertainty Factor for the Subchronic Oral
  [Reference Dose]
= Chronic Inhalation [Reference Concentration]
= Uncertainty Factor for the Chronic Inhalation
  [Reference Concentration]
= Chronic Oral [Reference Dose]
= Uncertainty Factor for the Chronic Oral
  [Reference Dose]
= Reference Identification Number for All
  Toxicity Values on the Same Line.
An example of this  information is shown in Figure 1,  HEAST Table  1:
Chemical
Level
Dose
Route
Species
Experiment Length
Target
Critical Effect

Subchronic [RfC]
UF
Subchronic [RfD]
UF
Chronic [RfC]
UF
Chronic [RfD]
UF
Reference
= GLYCIDALDEHYDE/000765-34-4
= NOAEL
= 10 PPM
= INHALATION:  INTERMITTENT
= RAT
= 12 WEEKS
= WHOLE BODY, BLOOD, KIDNEY
= DECREASED WEIGHT GAIN, HEMATOPOIETIC EFFECTS,
  EFFECTS
= 1E-2 mg/cu.m
= 300
= 4E-3 mg/kg/day
= 300
= 1E-3 mg/cu.m
= 3000
= IRIS
= IRIS
= 005968
                               -23-

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                                                                FIGURE  1

                                  Example  Data and  References  for Chemical Toxicity
                        HEAST  TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
GLYCIDALDEHYDE
NOAEL   10 PPM
       INHALATION:
       INTERMITTENT
     RAT
     12 WEEKS
000765-34-4

 WHOLE BODY
 BLOOD
 KIDNEY
                 CRITICAL EFFECT
DECREASED WEIGHT GAIN
HEMATOPOIETIC EFFECTS
EFFECTS
                                 Subchronic             Chronic
                             [RfC]       [RfD]      [RfC]      [RfD]
                            (mg/cu m) (ing/kg/day) (mg/cu m)  (mg/kg/day)
                                UF         UF       UF         UF
                              1E-2
                              300
4E-3
300
1E-3
3000
                                                                                          IRIS
                                                                                                       January 1992
                                                                                      REFERENCE
005968
       SUBCHRONIC  [RfD]  COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
       CHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
       GENERAL COMMENT:  ALSO SEE TABLE 3: CARCINOGENICITY.
                                 REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                     (OTHER  THAN  CARCINOGENICITY)
                                                                                                       January 1992
GLYCIDALDEHYDE                000765-34-4
       005968  HINE CH,  RJ GUZMAN, MK DUNLAP, R LIMA AND GS LOQUVAM.  1961.  STUDIES ON THE TOXICITY OF GLYCIDALDEHYDE.  ARCH ENVIRON HEALTH.
               2: 23-30.

               US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENTFOR GLYCIDALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

-------
Notice that a Chronic RfD for Glycidaldehyde is available on IRIS,
so it is not listed here.  Also notice that there are footnotes for
this  chemical  that  indicate  a route-to-route extrapolation  was
performed  and  that  there  is   information available  on  Table  3:
Carcinogenicity.

     Also given in Figure 1 is an example of  the  References  for

Table 1 for the same  chemical.  The reference is identified by the

chemical name  (Glycidaldehyde),  the CASRN  (00765-34-4),  and  the

reference number that links it with the toxicity values  (005968).

     The uncertainty  factor used  in calculating the [RfC] or [RfD]

reflects scientific  judgment regarding  the various  types of data

used to estimate [RfC] or [RfD] values.  An uncertainty factor of

10 is usually used to  account  for variation  in human sensitivity

among populations.  An additional 10-fold factor is usually used to

account for  each of  the  uncertainties assumed  when extrapolating

from animal  data to  humans, when  extrapolating from  a LOAEL to a

NOAEL, and when extrapolating  from subchronic to chronic exposure.

In order to reflect professional assessment of the uncertainties of

the study and the data base not explicitly  addressed by the above

uncertainty factors (e.g.,  completeness of the overall data base),

an additional uncertainty factor or modifying factor ranging from

greater than 0  to less than or equal to 10 is applied.  The default
         •
value for this modifying factor is 1.

     For chemicals  for which a  chronic  [RfC] or [RfD] is presented

in Tables 1 and 2,  a  subchronic [RfC] or  [RfD] is usually derived,

if not previously derived in the Agency documents that originally

addressed  the  chemical.    Subchronic  toxicity  values  are  not

evaluated by the RfD/RfC Work Group.   The subchronic [RfC] or [RfD]

is derived in either  of two ways:   1)   If an uncertainty factor was


                               -25-

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used  to  account  for  extrapolation  from  subchronic  to  chronic

exposure in the derivation of the chronic [RfC] or [RfD] , then, the

subchronic  [RfC]  or  [RfD]  is  derived  from the  same benchmark

concentration or dose without applying the uncertainty factor for

subchronic to chronic exposure extrapolation.  2)  If the chronic

[RfC] or [RfD]  was derived without use of an uncertainty factor for

extrapolating from subchronic to chronic exposure (e.g., if chronic

data were available), then,  the chronic  [RfC] or  [RfD] is adopted

as the subchronic [RfC]  or [RfD].

     Tables  1  and  2  list  the  uncertainty  factor  and modifying

factor, multiplied  together, to  form a single  factor under the

heading "Uncertainty Factor."  For example, the uncertainty factor

of 3000 listed for the chronic  inhalation [RfC] for Glycidaldehyde

reflects an uncertainty  factor of 1000  (10 for human sensitivity,

10 for extrapolation from animal to human, and 10  for extrapolation

from subchronic  to  chronic) and a modifying factor  of 3  (for an

inadequate data base);   the uncertainty factor of 500 listed for

the  subchronic oral  [RfD]  for  cyanide reflects  an uncertainty

factor of 100  (10 for human sensitivity, and 10  for extrapolation

from animal to human) and a modifying factor of  5  (to account for
                                                       •
tolerance to cyanide when ingested by food  rather than administra-

tion by gavage or by drinking water).

     [RfC] and [RfD] values are specific for  the  route of exposure

for which they are listed on Tables 1 and 2.   In  the few instances

where an  [RfD] or [RfC]  has been determined  from  another exposure

route, route-to-route extrapolation  is indicated  by a footnote.
                               -26-

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     The current methodology for the derivation of inhalation RfCs



is detailed in the document,  "Interim  Methods  for Development of



Inhalation Reference Doses"  (U.S.  EPA,  1990,  EPA/600/8-88/066F).



These methods are different from those used for oral RfDs because



of (1) the  dynamics  of the respiratory system  and  its diversity



across  species,  and  (2)  differences  in  the  physicochemical



properties  of  contaminants  (such as  the  size and  shape of  a



particle  or whether the  contaminant  is  an aerosol  or  a gas) .



Parameters  such  as  deposition,   clearance  mechanisms  and  the



physicochemical properties of the inhaled agent are considered in



the determination of the  effective dose delivered  to  the target



organ.



     An RfC value calculated  using  this interim methodology is



generally reported as a concentration in air (mg/m3) ,  although it



may be converted  to  a  corresponding inhaled dose  (mg/kg/day) by



dividing by 70 kg (an  assumed  human  body  weight),  multiplying by



20 m3/day  (an assumed human inhalation rate),  and adjusting by an



appropriate absorption  factor.  This conversion,  however, may often



be technically  incorrect,  and the appropriateness  of  doing this



must be evaluated on  a  case-by-case basis.  It is recommended that



HEAST  users that  plan  to  use  this  technique  read  a  further



discussion  of  the difficulties inherent in this  dose  conversion



that can be found in Appendix  A,  Section  II:  Dose Conversions On



HEAST.



     Inhalation [RfC] values reported in HEAs and early HEEDs that



were finalized prior to the implementation of the interim methods



were calculated using methods similar in concept to those used for





                               -27-

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oral [RfD]s.  These values are reported both  as a concentration in

air  (in  mg/m3 for continuous,  24 hours/day exposure)  under the

column [RfC],  and as  a corresponding inhaled dose  (in mg/kg/day) in

the footnotes called, Chronic  (Subchronic) [RfC]  Comment.   These

chemicals are listed in  Table 2: Alternate Methods - Subchronic and

Chronic Toxicity  (Other Than Carcinogenicity).

     [RfD] values for oral exposure are reported  as mg/kg/day.  An

oral [RfD] value can be  converted to a  corresponding concentration

in drinking water, assuming  human body weight  of 70 kg and water

consumption of 2  £/day, as follows:

     mg/£  in  water = oral FRfD]  (in mg/kg/day) x 70 kg
                                 2 £/day


     The  [RfC] or [RfD] is used as a  reference point for gauging

the potential effects of other exposures.   Usually, exposures that

are less than the [RfC] or [RfD] are  not likely  to be associated

with health risks.   As the  frequency  of exposures  exceeding the

[RfC] or  [RfD] increases  and as  the size of the excess increases,

the  probability  increases that  adverse  health  effects may  be

observed in a human  population.   Nonetheless, a clear distinction

that would  categorize all exposures below the [RfC]  or [RfD]  as

"acceptable"  (risk-free)  and all  exposures in excess of the  [RfC]

or  [RfD]  as  "unacceptable"  (causing   adverse  effects)  cannot  be

made.  In addition,  [RfC]  and [RfD] values, and particularly those

with limitations in the  quality or quantity of supporting data, are

subject to change as additional  information becomes available.

     When  [RfC]  or  [RfD]  values  are listed  in Tables  1  or 2 for

chemicals that are carcinogens, a footnote will refer to Table 3 if


                               -28-

-------
additional information concerning carcinogenicity is available in

that table.   [RfC]  .and  [RfD]  values that have been  derived for

carcinogens are based on noncancer endpoints only and should not be

assumed to be protective against carcinogenicity.


TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
          (OTHER THAN CARCINOGENICITY)

     Chemicals are listed in Table  2  when  the  [RfD] or [RfC] was

derived from alternative methods that are not currently practiced

by  the  RfD/RfC  Work Group.    The  table  consists primarily  of

inhalation [RfC] values determined from methodology that does not

follow the interim inhalation  methods adopted  by  the Agency, and

[RfC] or  [RfD] values based  on route-to-route  extrapolation with

inadeguate pharmacokinetic and  toxicity data.  A footnote is added

to each chemical  to  provide  a  short  explanation  of the specific

methodology used in calculating these  provisional toxicity values.

Most of these toxicity values were formerly listed  in Table 1.  In

some instances, the chemical  may be listed in both Tables 1 and 2

if the chemical has more  than one toxicity  value.  Table 2 follows

the same format as Table 1 (refer to Figure 1).



TABLE 3:  CARCINOGENICITY

  In assessing the carcinogenic potential of a chemical, the Human

Health Assessment Group  (HHAG)  of EPA  classifies the chemical into

one of the following  groups, according to  the  weight of evidence

from epidemiolbgic and animal studies:


    Group  A - Human Carcinogen  (sufficient evidence of carcino-
              genicity in humans)


                               -29-

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    Group B - Probable Human Carcinogen (Bl - limited  evidence
              of carcinogenicity  in humans;  B2  -  sufficient
              evidence  of  carcinogenicity  in  animals   with
              inadequate or lack of evidence in humans)

    Group C - Possible Human  Carcinogen (limited evidence  of
              carcinogenicity in animals and inadequate or lack
              of human data)

    Group D - Not  Classifiable as  to  Human  Carcinogenicity
              (inadequate or no evidence)

    Group E - Evidence of Noncarcinogenicity  for  Humans  (no
              evidence of carcinogenicity in adequate studies) .


These classifications  are shown under  [EPA Group] on Table 3.

    Quantitative carcinogenic  risk  assessments are  performed for

chemicals  in Groups  A and  B,  and on a case-by-case basis for

chemicals  in Group C.   Cancer [slope  factors]  (formerly called

cancer potency  factors in the Superfund Public Health Evaluation

Manual) are estimated through the use of mathematical extrapolation

models,  most   commonly   the   linearized  multistage  model,  for

estimating  the  largest   possible  linear  slope  (within   the 95%

confidence limit) at low  extrapolated doses that is consistent with

the data.  The [slope  factor] or risk is characterized  as  an upper-

bound estimate, i.e., the true risk to humans,  while not  identifi-

able, is not likely to exceed the  upper-bound estimate and in fact

may be lower.

    Quantitative carcinogenic estimates listed in Table  3 include

the following:

    [slope factor]   = risk per unit dose = risk per  mg/kg/day

    [unit risk] for inhalation exposure = risk per concentration
    unit in air = risk per
    [unit risk] for oral exposure = risk per concentration unit in
    water = risk per
                               -30-

-------
[Unit  risk]  estimates  for inhalation  and oral  exposure  can be

calculated by dividing the appropriate [slope factor] by 70 kg and

multiplying  by  the  inhalation rate  (20  m3/day)   or  the  water

consumption rate (2 £/day), respectively, for risk associated with

unit concentration  in air or  water.  Hence,

risk per jig/m3  (air) =  (risk per mg/kg/day) x    1   x 20 m3/day x  10"3(mg/jig)
                                       70 kg

risk per jjg/C (water)  = (risk  per mg/kg/day) x  1   x  2 (!/day x 10"3 (rag/jig)
                                        70 kg


Quantitative estimates of carcinogenic risk are listed under [Unit

Risk] or  [Slope  Factor] in  Table 3.  Information on the study and

data set used for estimation of the [slope factor] is given in the

other columns of Table 3.

    In Table  3,  the information listed is the following:

Chemical                   =  Chemical  Name/CASRN
Route                      =  Route  of  Administration
Species                    =  Tested Species
Experiment Length          =  Length of Exposure
Target                     =  Target Organ(s) Affected at Critical
                              Level
Cancer                     =  Tumors Observed  at  Critical  Level
                              (Not Specified  if More Than One Type
                              of Tumor)
[EPA Group]                =  EPA   Classification  by  Weight  of
                              Evidence
Oral  [Slope Factor]        =  Risk Per  Unit  Dose
Inhalation [Slope Factor]  =  Risk Per  Unit  Dose
Oral  [Unit Risk]           =  Risk Per  Concentration Unit in Water
Inhalation [Unit Risk]     =  Risk Per  Concentration Unit in Air
Reference                  =  Reference Identification  Number for
                              All Toxicity Values on the Same Line.


An example of this  information is shown in Figure 2, HEAST Table 3:

Chemical                   =  DIMETHYLHYDRAZINE,  1,2-/000077-78-1
Route                      =  ORAL:  DRINKING WATER
Species                    =  MOUSE
Experiment Length          =  LIFETIME
Target                     =  CARDIOVASCULAR SYSTEM
Cancer                     =  TUMORS
                               -31-

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                                                                FIGURE  2

                                   Example  Data  and  References  for  Carcinogenicity
CHEMICAL ROUTE
EXPERIMENT LENGTH
     SPECIES     TARGET
                                                   HEAST TABLE  3: CARCINOGENICITY
CANCER
           [SLOPE FACTOR]
 [EPA     ORAL     INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)-'
                                                                                                        January 1992
  [UNIT RISK]
 ORAL  INHALATION  REFERENCE
(ug/L)'1 (ug/cu m)'1
DIMETHYLHYDRAZINE,1,2-
       ORAL: DRINKING   LIFETIME
       WATER
                      MOUSE
                000077-78-1
                                 CARDIOVASCULAR
                                 SYSTEM
                                                    TUMORS
                                                   82
                       3.7E+1
                   3.7E+1
       Inhalation [Slope] Comment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
 1.1E-3
1.1E-2  009993
                                         REFERENCES FOR  HEAST TABLE 3:   CARCINOGENICITY
                                                                                                        January 1992
DIMETHYLHYDRAZINE,  1,2-                  000077-78-1
       009993  TOTH B AND K PATEL. 1982. CARCINOGENICITY DOSE-RESPONSE STUDY BY CONTINUOUS ADMINISTRATION OF  1,2-DIMETHYLHYDRAZINE
              DI-HYDROCHLORIDE IN MICE. I. LIGHT AND TRANSMISSION ELECTRON MICROSCOPIC STUDY OF COLONOIC NEOPLASMS. AM. J.  OF PATH.
              84:69-86.

              US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

-------
[EPA Group]                = B2
Oral [Slope Factor]        = 3.7E+1 (MG/KG/DAY)-1
Inhalation [Slope Factor]  = 3.7E+1 (MG/KG/DAY)-!
Oral [Unit Risk]           = 1.1E-3 (UG/LJ-1
Inhalation [Unit Risk]     = 1.1E-2 (UG/CU M)-l
Reference                  = 009993

Notice that  the inhalation values  for  1,2-Dimethylhydrazine was
extrapolated from the oral data.


   Also given in Figure  2 is an example of the References for Table

3  for  the same chemical.    The reference  is  identified  by the

chemical name (Dimethylhydrazine, 1,2-), the CASRN (000077-78-1),

and the  reference  number that links it  with the toxicity values

(009993)  .

   Quantitative carcinogenic estimates are specific for the route

of. exposure  for which they  are  listed  on Table 3.   Footnotes are

used to indicate those instances in which the values for inhalation

or oral exposure are based on extrapolation from another route of

exposure.    The route-to-route  conversion required  to  present

inhalation [slope factors]  in the units  of mg/kg/day is considered

by  the CRAVE  Work Group  to be  technically   incorrect.    It is

recommended that HEAST users who plan to use this information  read

a  further  discussion of the  difficulties  inherent in  this  dose

conversion which  can be  found  in  Appendix A, Section  II:   Dose

Conversions On HEAST.

   To estimate risk-specific concentrations in air from the  [unit

risk] in air as presented in Table 3,  the specified level of  risk

is divided by the [unit risk] for air.  Hence,  the air concentra-

tion (in jitg/m3)  corresponding to an upper-bound increased lifetime

cancer risk of IxlO"5 is calculated as follows:
                               -33-

-------
in air =
                                    IxlO'5
                          [unit risk]  in (jug/m)
                                              3 "1
     To estimate risk-specific concentrations  in drinking water

from the  oral  [slope factor] values  presented  in  Table 3,  the

specified level  of risk  is multiplied  by  70 kg  and divided by the

[slope  factor]   times  2  £/day.   Hence,  the  water  concentration

corresponding to an upper-bound increased lifetime cancer risk  of

IxlO"5 is calculated as follows:


     mg/£ in water =  _ IxlO'5 x  70  kg _
                    [slope factor]  in  (mg/kg/day) ~1   x 2 £/day
                               -34-

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             USER'S GUIDE:  RADIONUCLIDE  CARCINOGENICITY

INTRODUCTION

   EPA classifies  all radionuclides as  Group A carcinogens.   HEAST

Tables 4A  and 4B  list  ingestiori, inhalation and external exposure

cancer slope factors for radionuclides in units of picocuries and

becquerels,  respectively.1  Ingestion and inhalation  slope  factors

are  best estimates (i.e.,  median or 50th  percentile values)  of the

age-averaged, lifetime excess cancer incidence (fatal and nonfatal

cancer) risk per unit of activity inhaled or ingested, expressed  as

risk/pCi  or  risk/Bq.   External  exposure  slope factors  are  best
                                                        4
estimates  of lifetime excess cancer incidence risk  for each  year  of

exposure to external radiation from photon-emitting  radionuclides

distributed uniformly  in a  thick layer of soil,  and  are expressed

as  risk/yr per  pCi   (or  Bq)/gram soil.   When  combined  with  site-

specific   media  concentration   data   and   appropriate  exposure

assumptions2,  slope  factors  can be used to estimate lifetime cancer

risks  to   members  of  the  general  population  due  to  radionuclide

exposures.
   1 Slope factors are reported in Tables 4A and 4B in two different units of activity. Table 4A presents slope
factors in the customary units of picocuries (1 pCi = 10"12 curies (Ci) = 3.7xlO"2 nuclear transformations per
second) for consistency with the system used for radionuclides in the IRIS database; Table 4B presents slope
factors in the International System (SI) units of becquerels (1 Bq = 1 nuclear transformation per second;
approximately 27 pCi). Users can calculate cancer risks using slope factors expressed in either customary units
or SI units with equivalent results,  provided that they also use air, water and soil concentration values in the same
system of units.

    Agency standardized default exposure scenarios and assumptions for use in baseline risk assessment
are provided in EPA (1991), Risk Assessment Guidance for Superfund, Vol. I, Human Health Evaluation Manual,
Supplemental Guidance: "Standard Default Exposure Factors" (Interim Final), Office of Emergency and Remedial
Response, OSWER Directive 9285.6-03. [NTIS order number: PB 91-921314.]

                                    -35-

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INTENDED USERS AND APPLICATIONS

   HEAST users  include  individuals  from the  EPA,  other Federal

agencies,  States  and contractors  who  are  responsible  for the

identification, characterization and remediation of  sites contami-

nated with radioactive materials.  Radionuclide slope factors are

calculated by EPA's  Office of Radiation Programs (ORP)  to assist

HEAST users  with  risk-related evaluations and decision-making at

various stages of the remediation process.  During site assessment,

for example, slope factors are used in EPA's Hazard  Ranking System

(HRS)  to  assign  toxicity  factor  values  to radionuclides  to

calculate  site  scores.    During  the  remedial  investigation and

feasibility  study (RI/FS),  slope  factors are  used to  determine

baseline site risk,  to develop preliminary remediation goals, and

to evaluate  cleanup  alternatives.   For  further  examples  on the

application  of  radionuclide  slope factors in risk evaluations,

users are referred to the  following EPA  documents:


   •  Hazard  Ranking System  (HRS),   Federal  Register  (55   FR
     515320), December  1990.

   •  Risk  Assessment Guidance for Superfund;  Volume I - Human
     Health  Evaluation Manual  (RAGS/HHEM) , Part  A,  Baseline
     Risk  Assessment (EPA/540/1-89/002).

   •  RAGS/HHEM  Part  B,  Development  of Risk-Based  Preliminary
     Remediation  Goals   (OSWER  Directive 9285.7-01B).  [NTIS
     order number:   PB  92-963333.]

   •  RAGS/HHEM Part  C, Risk Evaluation of Remedial Alternatives
     (OSWER  Directive 9285.7-01C).  [NTIS order number:  PB 92-
     963334. ]


   Copies of RAGS/HHEM Parts A, B and C are available to the public

from the National Technical  Information Service  (NTIS)  at  (703)
                               -36-

-------
487-4650.   Copies  are available  to  EPA  staff  by calling  the



Superfund Documents Center at FTS 260-9760.








RADIATION EFFECTS



   Ionizing radiation has been shown to be a carcinogen, a mutagen,



and a teratogen.  At sufficiently high doses, radiation acts as a



complete carcinogen,  serving as both an initiator and promoter, and



can induce cancers in nearly any tissue or organ in both humans and



animals.  At lower doses and dose rates, radiation produces delayed



responses in the form of increased incidence of cancer long after



the exposure period.   These delayed responses have been documented



extensively in  epidemiological  studies  of  Japanese atomic bomb



survivors, underground uranium  miners, radium dial  painters,  and



patients subject to a variety of radiation treatments.  Laboratory



animal research and mammalian tissue culture studies have provided



additional, collaborative data.



   Mutagenic effects of radiation have been demonstrated primarily



in animal and tissue culture studies; limited data from studies of



A-bomb survivors indicate that humans may be as sensitive or less



sensitive than animals to radiogenic mutagenicity.  Data are also



available from  both  human  and animal studies on  the teratogenic



effects  of  radiation.  These data show that  the fetus  is most



sensitive to  radiation injury  during  the  early stages  of organ



development  (between  8 and  15  weeks  for  the  human  fetus).



Resultant radiation-induced malformations depend on which cells are



most actively differentiating at the time of exposure.
                               -37-

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   EPA classifies all radionuclides as Group A carcinogens, based



on  their  property  of  emitting  ionizing radiation  and  on  the



extensive weight of  evidence provided by epidemiological studies of



radiogenic cancers  in  humans.   At Superfund radiation sites,  EPA



generally  evaluates potential  human health  risks based  on  the



radiotoxicity,  i.e.,  adverse  health  effects caused  by  ionizing



radiation, rather than on the chemical toxicity,  of each radionuc-



lide present.  These evaluations consider the carcinogenic effects



of radionuclides only.  In  most  cases, cancer risks are limiting,



exceeding both mutagenic and teratogenic  risks.







DERIVATION OP RADIONUCLIDE  SLOPE FACTORS



   EPA's Office of Radiation Programs (ORP) calculates radionuclide



slope factor values using  health effects data  and dose  and risk



models  from a  number of  national  and  international scientific



advisory  commissions and  organizations,  including  the  National



Academy  of  Sciences   (NAS),  the National Council  on Radiation



Protection and Measurements (NCRP), the  United Nations Scientific



Committee  on the Effects of Atomic  Radiation  (UNSCEAR),  and the



International  Commission on Radiological Protection  (ICRP).   A



detailed discussion of ORP's approach and assumptions  is provided



in Risk  Assessment Methodology.  Environmental  Impact Statement,



NESHAPS for Radionuclides.  Background Information Document - Volume



X (EPA 520/1-89-005: September  1989).



   Radionuclide slope factors are calculated for  each radionuclide



individually, based  on its unique chemical, metabolic and radio-
                               -38-

-------
active  properties.    The  calculation  uses  EPA's  computer  code

RADRISK3, life table analyses  (described  in EPA 520/1-89-005), and

cancer  risk estimates  based largely on  the results of  the NAS BEIR

III report.4  Ingestion  and inhalation slope factors  for radionu-

clides  account for:

   •  the amount  of radionuclide  transported  into  the  blood-
      stream from  either  the gastrointestinal (GI) tract follow-
      ing ingestion, or  from the lungs  following inhalation;

   •  the ingrowth  and  decay  of  radioactive progeny  produced
      within the body subsequent to intake;

   •  the distribution and  retention  of each radionuclide (and
      its associated progeny,  if  appropriate)  in  body  tissues
      and organs;

   •  the radiation dose delivered to  body tissues  and  organs
      from  the  radionuclide  (and  its  associated progeny,  if
      appropriate); and

   •  the sex, age,  and  organ-specific risk  factors  over  the
      lifetime of  exposure.


   The  slope  factors  are  the  average risk  per  unit  intake  or

exposure  for  an individual  in a stationary population with vital

statistics   (mortality rates)  of the  United  States  in 1970.  (The

expected  lifetime for  an individual in  this population is about 70

years.)   Consequently, radionuclide ingestion and inhalation slope

factors are not expressed  as  a  function  of body weight  and time,

and do  not  require corrections  for gastrointestinal absorption or

lung  transfer efficiencies.
   3 Dunning, D.E. Jr., Leggett, R.W., and Yalcinatas, M.G. (1980). "A Combined Methodology for Estimating
Dose Rates and Health Effects from Exposure to Radioactive Pollutants," ORNL/TM-7105.

   4 National Academy of Sciences (1980). The Effects on Populations of Exposure to Low Levels of Ionizing
Radiation. Report of the Committee on the Biological Effects of Ionizing Radiation (BEIR III). National
Research Council, Washington, D.C. EPA anticipates that the slope factors for radionuclides in HEAST will
be modified in the future to incorporate the results of BEIR V (1990) and/or other relevant sources.

                                 -39-

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  NOTE:  The GI absorption values  (f,) . ICRP lung classifications
  (D,  w,  Y)  and radioactive half-lives  are provided  in HEAST
  Tables 4A  and 4B for reference  only  and should not be used  to
  correct, modify, or in any way adjust  radionuclide slope factors
  or intake  assumptions in risk calculations.
   External  slope factors  provide cancer risk  estimates per unit

exposure  to  a uniform  radionuclide concentration  in  soil.   These

factors,  which  account  for photon  energy  flux  attenuation  and

buildup in soil,  are calculated for each radionuclide using volume

and surface  dose factors derived  using the computer code DFSOIL.5

     Because  of  the  radiation  risk  models   employed  for  both

internal  and external  exposures,  slope factors for radionuclides

are characterized as best estimates  (i.e.,  median or 50th percen-

tile  values)  of the age-averaged  lifetime  total excess  cancer

incidence risk per unit intake  or exposure.



ABOUT THE INFORMATION PROVIDED  IN TABLES  4A AND 4B:

   Tables 4A  and   4B  list  ingestion,  inhalation  and  external

exposure  slope factors of principal radionuclides, and provide key

parameter values  used in the derivation of slope factor values.  In

both tables, radionuclides are presented alphabetically by element

and atomic weight.

   Selected  radionuclides and radioactive decay chain products are

designated in  the HEAST tables with the suffix "+D"  (e.g., U-238+D,

Ra-226+D,  Cs-137+D)  to indicate  that cancer  risk estimates  for
   5 Sjoreen, A.L., Kocher, D.C., Killough, G.G. and Miller C.W. (1984). "MLSOIL and DFSOIL - Computer
Codes to Estimate Effective Ground Surface Concentrations for Dose Computations," Oak Ridge National
Laboratory, Oak Ridge, TN, ORNL-5974.


                                -40-

-------
these  radionuclides  include  the contributions  from  their  decay

products,  assuming equal  activity  concentrations  (i.e.,  secular

equilibrium)  with  the parent nuclide  in the  environment.6   Decay

chains are identified in Exhibit 1,  and members of these chains are

noted in  the HEAST  tables with  a  dagger ("t").

   In most  cases, site-specific analytical data  should  be  used to

establish the  actual  degree  of  equilibrium  between  each  parent

radionuclide  and   its  decay  products  in  each  media sampled.

However,  in  the absence  of  empirical  data,  the "+D"  values  for

radionuclides should  be used unless there are compelling  reasons

not to.  For  example,  the external slope factors  for Cs-137  and Cs-

137+D are 0.0 and 2xlO"6 (risk per year per pCi/gram) , respectively.

The  value  for  Cs-137-t-D  is  higher  because it  includes the  risk

contribution from cesium's short-lived gamma-emitting decay  product

Ba-137m  (half-life, 25.5  minutes) which, under most environmental

conditions,  will be in secular  equilibrium with  Cs-137.

   Note  that  there may be  circumstances,  such  as  long disposal

times  or  technologically  enhanced concentrations  of  naturally

occurring radionuclides,  that may necessitate the  combination of

the  risks of a  parent radionuclide  and its  decay  products  over

several contiguous subchains. For example, Ra-226 soil  analyses at

a site  might  show  that  all   radium  decay  products  are  present in

secular  equilibrium down to  stable  Pb-206   (See Exhibit 1) .   In
   6 There is one exception to the assumption of secular equilibrium: For the inhalation slope factor for Rn-
222+D reported in HEAST Tables 4A and 4B, ORP assumes a 50% equilibrium value for radon decay products
(Po-218, Pb-214, Bi-214 and Po-214) in air. ORP also used a slightly different risk model to calculate the
inhalation slope factor for Rn-222 + D based on human health risk estimates from recent epidemiological studies.
Consequently, users should not be concerned that the Rn-222+D inhalation slope factor in the HEAST tables
does not equal numerically the summation of individual inhalation factors for Rn-222 plus radon decay products.

                                 -41-

-------
this  case,  Ra-226 risk  calculations  should  be  based  on   the



ingestion,  inhalation  and  external  exposure slope  factors for the



Ra-226+D  subchain,  plus  the  ingestion,  inhalation and external



exposure  factors  for  the  Pb-210+D subchain.    For actual sites,



users should consult with a health physicist or radiochemist  (1) to



evaluate the site-specific analytical data to  determine the degree



of equilibrium  between parent radionuclides and decay members of



contiguous  decay chains and  (2) to assist in the combination of



appropriate  slope factor values.   For  health physics and radio-



analytical   support,   HEAST users  may  contact   EPA's  Regional



Radiation  Program  Managers,   ORP's National  Air  and  Radiation



Laboratory   (NAREL)  in Montgomery,  Alabama,  ORP's  Las  Vegas



Laboratory  (ORP-LV) in Las  Vegas, Nevada,  or the ORP staff at EPA



Headquarters in  Washington, D.C., listed  in Exhibit 2.



   A Chemical Abstract System Reference Number (CASRN) is assigned



to each radionuclide  for  identification  and  reporting  accuracy



during  risk assessments.  Users should report  a  CASRN  for  all



radionuclides   (both   parent   and   decay   product  radionuclides)



included in risk calculations.  Radioactive half-lives are provided



in the HEAST tables for reference.



   The designations "D", "W",  and "Y" presented under the heading



"ICRP Lung Class"  in the tables  refer to  the lung  clearance times



for inhaled particulate radionuclides, expressed as days (D), weeks



(W) ,  or years (Y), as  recommended by the  International Commission



on Radiological  Protection (ICRP).   Gaseous radionuclides,  e.g.,



Rn-222, are designated with  an asterisk  ("*").   "GI Absorption



Factors, f," are the fractional amounts of each radionuclide that





                               -42-

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may be absorbed  from the gastrointestinal  (GI)  tract  into blood



following an oral intake.  The ICRP lung clearance classifications



and GI absorption factors provided in  Tables  4A and  4B  are the



default  values  that  EPA used  to  calculate radionuclide  slope



factors for inhalation and ingestion exposures, respectively. These



factors are provided for  reference  only (see the Note  Box on the



previous page).








WHERE TO ADDRESS QUESTIONS ABOUT RADIONUCLIDE SLOPE FACTORS



   EPA continuously reviews  the  scientific literature on radiation



effects to ensure that the Agency's risk assessment methodologies



are  consistent  with  current models  and assumptions.    As  risk



assessment methodologies are refined,  the slope factors in Tables



4A and 4B will be revised and updated.



   HEAST  users  with  questions  about  radionuclide slope factor



values and their use in radiation risk assessments should contact



the Remedial Guidance Section of the Radiation Assessment Branch of



ORP  at  (202) 260-9630  or  FTS  260-9630.   Written requests for



assistance can be sent by fax to (202) 260-6918 or FTS 260-6918.
                               -43-

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Exhibit 1: Radioactive Decay Chains Included in HEAST Tables 4A and 4B:
Principal Decay Chain
Uranium-238
Uranium-235
Thorium-232
Subchain3
U-238 + D
U-234
Th-230
Ra-226 + D
Pb-210 + D
Pb-206
U-235 + D
Pa-231
Ac-227 + D
Pb-207
Th-232
Ra-228 + D
Th-228 + D
Pb-208
Members'*
U-238
Th-234
Pa-234
U-234
Th-230
Ra-226
Rn-222tf
Po-218
Pb-214
Bi-214
Po-214
Pb-210
Bi-210
Po-210
Pb-206
U-235
Th-231
Pa-231
Ac-227
Th-227 [99%]
Ra-233
Rn-219
Po-215
Pb-211
Bi-211
Tl-207
Pb-207
Th-232
Ra-228
Ac-228
Th-228
Ra-224
Rn-220
Po-216
Pb-212
Bi-212
Po-212 [64%]
Tl-208 [36%]
Pb-208
Half-life0
4.468E + 09 Y
2.410E + 01 D
1.170E + OOM
2.445E + 05 Y
7.700E+04 Y
1.600E+03 Y
3.823E + OOD
3.050E + 00 M
2.680E + 01 M
1.990E + 01 M
1.637E-04 S
2.226E + 01 Y
5.013E + OOD
1.384E + 02 D
[Stable]
7.038E+08 Y
2.552E + 01 H
3.726E + 04 Y
2.177E + 01 Y
1.872E + 01 D
1.143E + 01 D
3.960E + OOS
1.778E-03 S
3.610E + 01 M
2.130E + 00 M
4.770E + 00 M
[Stable]
1.405E+10 Y
5.750E + 00 Y
6.130E + 00 H
1.913E + 00 Y
3.620E + 00 D
5.561E + 01 S
1.460E-01 S
1.064E + 01 H
6.055E + 01 M
2.980E-07 S
3.053E + 00 M
[Stable]
                               -44-

-------
      Exhibit 1: Radioactive Decay Chains Included in HEAST Tables 4A and 4B
                                         (Continued)*
Principal Decay Chain
Neptunium-237












Americium-243

Cesium-137

Strontium-90

Subchain51
Np-237 + D

U-233
Th-229 + D








Bi-209
Am-243 + D

Cs-137 + D

Sr-90 + D

Members'*
Np-237
Pa-233
U-233
Th-229
Ra-225
Ac-225
Fr-221
At-217
Bi-213
Po-213 [98%]
Tl-209 [2%]
Pd-209
Bi-209
Am-243
Np-239
Cs-137
Ba-137m
Sr-90
Y-90
Half-life0
2.140E + 06 Y
2.700E + 01 D
1.592E + 05 Y
7.340E + 03 Y
1.480E + 01 D
l.OOOE + 01 D
4.800E + 00 M
3.230E-02 S
4.565E + 01 M
4.200E-06 S
2.200E + 00 M
3.253E + OOH
[Stable]
7.380E + 03 Y
2.355E + OOD
3.017E + 01 Y
2.552E + OOM
2.860E + 01 Y
6.410E + 01H
* See the discussion on radioactive decay chains in the User's Guide.
a Radioactive decay chains included in HEAST Tables 4A and 4B. Radionuclides marked with the suffix
" + D" include risks from decay chain members, assuming secular equilibrium (i.e., equal activity concentra-
tions) in the environment.
 The chain of decay products of a parent radionuclide extends to (but does not include) members of the
next subchain (e.g., U-238 + D includes U-238, Th-234 and Pa-234, but not U-234). Note that there may be
circumstances when it  may be necessary to combine the risks for a parent radionuclide over several
contiguous subchains, depending on the conditions of equilibrium. Branches in the decay chain are
indicated in square brackets with branching percentages in parentheses.
tt A radon-222 decay subchain, Rn-222 + D, is also included in the HEAST tables, comprised  of ingestion,
inhalation and external exposure slope factors for Rn-222 plus the corresponding slope factors for each of
its decay products (Po-218, Pb-214, Bi-214 and Po-214).  For  the ingestion and external exposure slope
factors for Rn-222 + D, decay products are assumed to be in secular  equilibrium.  For the inhalation  slope
factor, decay products  are assumed to be in 50% equilibrium.
0 Radioactive half-life in years (Y), days (D), hours (H), minutes (M) or seconds (S).
                                             -45-

-------
                            Exhibit 2 EPA Radiation Program Staff
Tom D'Avanzo
Radiation Program Manager, Region 1
U.S. Environmental Protection Agency
John F. Kennedy Federal Building
Room 2311
Boston, MA 02203

Paul A. Giardina
Radiation Program Manager, Region 2
U.S. Environmental Protection Agency
Room 1005 (AWM-RAD)
26 Federal Plaza
New York, NY 10278

Lewis Felleisen
Radiation Program Manager, Region 3
Special Program Section (3AM12)
U.S. Environmental Protection Agency
841 Chestnut Street
Philadelphia, PA 19107

Chuck Wakamo
Radiation Program Manager, Region 4
U.S. Environmental Protection Agency
345 Courtland  Street, ME
Atlanta, GA 30365

Gary V. Gulezian
Radiation Program Manager, Region 5
(5AR26)
U.S. Environmental Protection Agency
230 S. Dearborn Street
Chicago, IL 60604

Donna Ascenzi
Radiation Program Manger, Region 6
U.S. Environmental Protection Agency
Air Enforcement Branch (6T-E)
Air, Pesticides  and Toxics Division
1445 Ross Avenue
Dallas, TX 75202-2733

Gale Wright
Radiation Program Manager, Region 7
U.S. Environmental Protection Agency
726 Minnesota Avenue
Kansas City, KS 66101
FTS: 835-4502
COMM: (617) 565-4502
FTS: 264-4110
COMM: (212) 264-4110
FTS: 597-8326
COMM: (215) 597-8326
FTS: 257-3907
COMM: (404) 347-3907
FTS: 886-6258
COMM: (312) 353-2206
FTS: 255-7223
COMM: (214) 655-7223
FTS: 276-7600
COMM: (913) 551-7600
                                             -46-

-------
                     Exhibit 2. EPA Radiation Program Staff  (Continued)
Milton W. Lammering                              FTS: 330-1709
Radiation Program Manager, Region 8                COMM: (303) 293-1713
(8HWM-RP)
U.S. Environmental Protection Agency
Suite 500
999 18th Street
Denver, CO 80202-2405

Michael S. Bandrowski                              FTS:484-1048
Radiation Program Manager, Region 9                COMM: (415) 744-1048
(AM)
U.S. Environmental Protection Agency
75 Hawthorne Street
San Francisco, CA 94105

Jerry Leitch                                        FTS: 399-7660
Radiation Program Manager, Region 10               COMM: (206) 442-7660
(AT-082)
U.S. Environmental Protection Agency
1200 Sixth Avenue
Seattle, WA 98101

Samuel T. Windham, Director                        FTS: 228-3400
National Air and Radiation                          COMM: (205) 270-3400
Environmental Laboratory (NAREL)
Office of Radiation Programs
U.S. Environmental Protection Agency
1504 Avenue A
Montgomery, AL 36115-2601

Jed Harrison, Acting Director                        FTS: 545-2476
Office of Radiation Programs-                        COMM: (702) 798-2476
Las Vegas Facility (ORP/LVF)
U.S. Environmental Protection Agency
P.O. Box 98517
Las Vegas, NV 89193-8517

Robert S. Dyer,  Chief                               FTS: 260-9630
Office of Radiation Programs - HQ                   COMM: (202) 260-9630
Radiation Assessment Branch
Radiation Studies Division (ANR-461)
U.S. Environmental Protection Agency
401 M Street, SW
Washington, DC 20480
                                             -47-

-------
                     Exhibit 2. EPA Radiation Program Staff (Concluded)
Anthony B. Wolbarst, Chief                         FTS: 260-9630
Office of Radiation Programs - HQ                  COMM: (202) 260-9630
Remedial Guidance Section
Radiation Assessment Branch
Radiation Studies Division (ANR-461)
U.S. Environmental Protection Agency
401 M Street, SW
Washington, DC 20480
                                             -48-

-------
                          HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC  TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                                 January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                          SPECIES
                    EXPERIHENT  LENGTH TARGET
                                                     CRITICAL EFFECT
                                  Subchronic             Chronic
                                [RfC]      [RfD]      [RfC]       [RfD]
                              (mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                 UF         UF        UF         UF
ACENAPHTHENE
NOAEL   175     MG/KG/DAY  MOUSE
        ORAL:  GAVAGE       90 DAYS
                                   000083-32-9

                                     LIVER
                                                     HEPATOTOXICITY
                                          6E-1
                                          300
                     IRIS
ACENAPTHYLENE                  000208-96-8
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ACEPHATE
LOAEL   2      PPM        RAT
        ORAL:  DIET         13 WEEKS
                                   030560-19-1
                                     BRAIN
DECREASED CHOLINESTERASE
ACTIVITY
4E-3
30
                               REFERENCE
010165
                                                                                                                             005202
                                                                                                                   IRIS      005833
        GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

                                   000067-64-1
ACETONE
NOEL    100   MG/ KG/0 AY    RAT
        ORAL:  GAVAGE       90 DAYS
ACETONE  CYANOHYDRIN
NOEL    10.8  MG CN/KG/DAY RAT
        ORAL:  DIET         104 WEEKS
                                    LIVER
                                    KIDNEY
                                    KIDNEY

                                   000075-86-5

                                     WHOLE  BODY
                                     THYROID
                                     CENTRAL
                                     NERVOUS  SYSTEM
                                                     INCREASED WEIGHT
                                                     INCREASED WEIGHT
                                                     NEPHROTOXICITY
                                                     ALTERED WEIGHT
                                                     EFFECTS
                                                     EFFECTS
                                                                                               1E+0
                                                                                               100
                                          7E-2
                                          500
                                                              IRIS      005204
                    7E-2       005776
                    500
        SUBCHRONIC  [RfD] COMMENT:  CALCULATED  BY ANALOGY TO FREE CYANIDE  BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.
        CHRONIC  [RfD] COMMENT:  CALCULATED BY  ANALOGY TO FREE CYANIDE BY  CORRECTING FOR DIFFERENCES IN  MOLECULAR WEIGHT.
        SUBCHRONIC  [RfC] COMMENT:  ALSO SEE HEAST TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC  [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS,  ERA'S  INTEGRATED RISK  INFORMATION  SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254,  FTS 684-7254.
                                                                                                                                         1-1

-------
                          HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)       January 1992

                                                                                         Subchronic             Chronic
CHEMICAL  DOSE             SPECIES                                                     [RfC]       [RfD]      [RfC]        [RfO]     REFERENCE
LEVEL     ROUTE      EXPERIMENT LENGTH TARGET           CRITICAL  EFFECT                 (mg/cu m) (mg/kg/day) (mg/cu m)  (na/kg/day)
                                                                                        UF          UF        UF          UF


ACETONITRILE                    000075-05-8
NOAEL   100     PPM        MOUSE                                                                 6E-2                  IRIS       005210
        INHALATION:        92 DAYS     ERYTHROCYTES     DECREASED CELL COUNT                       300
        INTERMITTENT
                                      BLOOD            DECREASED HEMATOCRIT
                                      LIVER            HEPATIC LESIONS

        SUBCHRONIC  [RfD] COMMENT:  BASED  ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF  0.5.
        CHRONIC [RfD]  COMMENT:  BASED ON  ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.  UNDER REVIEW, CURRENT NUMBER SUBJECT TO
        CHANGE.
        SUBCHRONIC  [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC [RfC]  COMMENT:  ALSO SEE  HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)


ACETOPHENONE                    000098-86-2
NOAEL   10,000   PPM        RAT                                                                    1E+0                 IRIS       005212
        ORAL: DIET         17 WEEKS                    NONE  OBSERVED                               300

        SUBCHRONIC  [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC [RfC]  COMMENT:  ALSO SEE  HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

ACROLEIN                         000107-02-8
LOAEL   0.917 MG/CU M
                          RAT         NASAL EPITHELIUM RHINITIS                         2E-4                 IRIS                 010429
        INHALATION:        13 WEEKS    NASAL EPITHELIUM NEUTROPHILIC INFILTRATION        100

NOAEL   15.6    MG/KG/DAY  RAT                                                                    2E-1                  2E-2       010390
        ORAL: WATER        90 DAYS                                                                100                  1000

        GENERAL COMMENT:  ALSO SEE HEAST  TABLE 3: CARCINOGENICITY.

ACRYLAMIDE                       000079-06-1
NOEL    0.2  MG/KG/DAY    RAT                                                                    2E-3      IRIS       IRIS       005835
        ORAL: DRINKING    90 DAYS     NERVE            DAMAGE                                      100
        WATER

        CHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (11/1/91) BY  THE RfD/RfC WORKGROUP.
        GENERAL COMMENT:  ALSO SEE HEAST  TABLE 3: CARCINOGENICITY.
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER  SUPPORT: (513) 569-7254,  FTS 684-7254.           1-2

-------
                         HEAST TABLE 1:  SUBCHRONIC  AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                January 1992
CHEMICAL DOSE
LEVEL     ROUTE
          SPECIES
     EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
                                                   Subchronic             Chronic
                                                 [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
                                               (mg/cu m) (mg/kg/day) (cng/cu m)  (mg/kg/day)
                                                                                     UF
                                                                                 UF
                                                                       UF
                                                                UF
ACRYLIC  ACID
LOAEL   5          PPM
        INHALATION:
        INTERMITTENT
          HOUSE
          13- WEEKS
NOAEL   83     MG/KG/DAY  RAT
        ORAL: DRINKING    3 MONTHS
        WATER
000079-10-7

  NASAL MUCOSA
                     WHOLE BODY
                     ORGANS,  MAJOR
                                     LESIONS
                 DECREASED WEIGHT
                 ALTERED WEIGHT
                               3E-3
                               100
ADIPONITRILE                    000111-69-3
        DATA  INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
ALACHLOR
NOEL    1     MG/KG/DAY   DOG
        ORAL: CAPSULE     1 YEAR
                    015972-60-8

                     BLOOD           ANEMIA
                     SITES,  MULTIPLE  HEMOSIDEROSIS
        SUBCHRONIC [RfD]  COMMENT:  THE  CHRONIC ORAL [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST  TABLE 3: CARCINOGENICITY.
ALDICARB
LOAEL   0.02
MG/KG/DAY
        ORAL: DIET


ALDRIN
LOAEL   0.025  MG/KG/DAY

        ORAL: DIET
          DOG
          1 YEAR
          RAT
          2 YEARS
000116-06-3


  BLOOD

000309-00-2


  LIVER
CHOLINESTERASE INHIBITION
                                                    LESIONS
        SUBCHRONIC [RfD]  COMMENT:  THE  CHRONIC ORAL [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST  TABLE 3: CARCINOGENICITY.

ALLIDOCHLOR                     000093-71-0
        DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
ALLYL  ALCOHOL
NOEL    50      PPM
        ORAL: DRINKING
        WATER
                    000107-18-6
          RAT
          15 WEEKS
  LIVER
  KIDNEY
EFFECTS
EFFECTS
                                                           8E-1
                                                           100
                                                           1E-2
                                                           100
2E-4
100
                                         3E-5
                                         1000
5E-2
100
          IRIS
                                                                                                   IRIS
                                                              IRIS
                                                                                                                  IRIS
                                                                                                   IRIS
                                                                                                   IRIS
010346
                                                                                                             005836
                                                                                                             005157
                                                                        005837
                                                                        010433
                                                                                                             005159
                                                                                                             005838
                                                                                         005839
IRIS,  EPA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER  INFORMATION: IRIS USER  SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                                        1-3

-------
                        HEAST TABLE 1:  SUBCHRONIC  AND  CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)      January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
                                                  CRITICAL EFFECT
                                                  Siixhronic            Chronic
                                               [RfC]      [RfO]      [RfC]       [RfD]     REFERENCE
                                             (ms/cu m) (mg/kg/day) Cmg/cu m)  (mg/kg/day)
                                                 UF         UF       UF         UF
ALLYL  CHLORIDE
NOAEL    17    MG/CU M
        INHALATION:
        INTERMITTENT
     RABBIT
     5 MONTHS
000107-18-6

  NERVOUS SYSTEM   NEUROTOXICITY
                              1E-2
                              300
       SUBCHRONIC  [RfD]  COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
       CHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.

ALUMINUM                        007429-90-5
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ALUMINUM PHOSPHIDE
NOAEL   0.43 MG/KG/DAY

       ORAL:  DIET
AMETRYN
NOEL     10     MG/KG/DAY
        ORAL: GAVAGE
               020859-73-8
     (0.51 MG/KG OF FOOD)
     RAT
     2 YEARS     WHOLE  BODY
                UNSPECIFIED
     RAT
     13 WEEKS
               000834-12-8
  LIVER
                                                  ALTERED WEIGHT
                                                  ALTERED CLINICAL PARAMETERS
EFFECTS
AMINO-2-NAPHTHOL,  1-         002834-92-6
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

AMINO-2-NAPHTHOL HYDROCHLORIDE,  1-    001198-27-2
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
AMINOPHENOL,  M-
NOAEL    1300   PPM        RAT
        ORAL: DIET         13 WEEKS
               000591-27-5

                WHOLE  BODY
                THYROID
                 ALTERED WEIGHT
                 ALTERED WEIGHT
AMINOPHENOL,  0-               000095-55-6
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

AMINOPHENOL,  P-               000123-30-8
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
5E-3
300
                                                         4E-4
                                                         100
                                                         9E-2
                                                         100
                                                         7E-1
                                                         100
                                                                                 IRIS
5E-2
3000
                                                                                                     010369
                                                                                                     005162
                                                            IRIS       010255
                                                                                           IRIS      005841
                                                                                                     005842
                                                                                                     005843
                                                            7E-2       005844
                                                            1000
                                                                                                     005845
                                                                                                     005846
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                 1-4

-------
                          HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
                                                                                                                                   January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                          SPECIES
                    EXPERIMENT LENGTH TARGET
                                                      CRITICAL EFFECT
                                                   Sifcchronic             Chronic
                                                 [RfC]      [RfO]      [RfC]        [RfD]     REFERENCE
                                               (mq/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                  UF          UF       UF         UF
AMINOPYRIDINE,  4-
NOAEL   3       PPM        RAT
        ORAL:  DIET         90 DAYS
                                    000504-24-5

                                      LIVER
                                      BRAIN
                                                      INCREASED WEIGHT
                                                      INCREASED WEIGHT
                                                           2E-4
                                                           1000
2E-5
10000
005847
        CHRONIC [RfD] COMMENT:  UNDER REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.

                                    007664-41-7

                          HUMAN
AMMONIA
NOAEL    6.4 MG/CU M
NOAEL
        INHALATION:
        INTERMITTENT
        34      MG/L
        ORAL:  DRINKING
        WATER
                          HUMAN
                                      NASAL CAVITY
                                      LUNGS
                                      LUNGS
                                      SENSORY
                RHINITIS
                PNEUMONIA
                LESIONS
                                                      TASTE  THRESHOLD
                                                                                      1E-1
                                                                                      30
                                                                                                           IRIS
                                                           34 mg/L
                                                           1
34 mg/L
1
                                                                                          010392
005166
        SUBCHRONIC  [RfD] COMMENT:  GIVEN AS CONCENTRATION IN DRINKING WATER.  SPECIFICALLY RELATED  TO ORGANOLEPTIC THRESHOLD.  SAFE CONCENTRATION MAY
                                  BE  HIGHER, BUT DATA ARE INADEQUATE TO ASSESS.
        CHRONIC [RfD] COMMENT:  UNDER  REVIEW BY  [RfD] WORK GROUP. GIVEN AS CONCENTRATION IN DRINKING WATER. SPECIFICALLY RELATED TO ORGANOLEPTIC
                               THRESHOLD. SAFE CONCENTRATION MAY BE HIGHER,  BUT DATA ARE INADEQUATE TO ASSESS.
ANILINE
NOAEL   19 MG/CU M

        INHALATION:
        INTERMITTENT

NOAEL   19  MG/CU M

        INHALATION:
        INTERMITTENT

NOAEL   19  MG/CU M

        INHALATION:
        INTERMITTENT
                                    000062-53-3
                          GUINEA PIG
                          20-26
                          WEEKS
                          RAT
                          20-26
                          WEEKS
                          MOUSE
                          20-26
                          WEEKS
SPLEEN
SPLEEN
SPLEEN
                PATHOLOGY
                PATHOLOGY
                PATHOLOGY
                                                 1E-2
                                                 300
                                                                                                           IRIS
          010370
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS,  EPA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254,  FTS  684-7254.
                                                                                                                                            1-5

-------
CHEMICAL  DOSE
LEVEL     ROUTE
                          HEAST TABLE  1:  SUBCHRONIC  AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)       January 1992
                  SPECIES
            EXPERIMENT LENGTH TARGET
                                                     CRITICAL EFFECT
                                                              Sifcchronic             Chronic
                                                           [RfC]      [RfO]       [RfC]       [RfD]
                                                         (rng/cu m)  (mg/kg/day) (mg/cu ro)  (mg/kg/day)
                                                             UF         UF       UF         UF
                                                                                          REFERENCE
ANTHRACENE
NOEL    1000   MG/KG/DAY  MOUSE
        ORAL:  GAVAGE       90 DAYS

ANTIMONY  (METALLIC)
LOAEL   0.35 MG SB/KG/DAY  RAT
        ORAL:  DRINKING     LIFETIME
        WATER

ANTIMONY  PENTOXIDE
LOAEL   0.46  MG/KG/DAY    RAT
        ORAL:  DRINKING     LIFETIME
        WATER
                            000120-12-7
                            007440-36-0

                             WHOLE BODY
                             BLOOD

                            001314-60-9

                             WHOLE BODY
                             BLOOD
                                             NONE OBSERVED
                           INCREASED MORTALITY
                           ALTERED CHEMISTRIES
                           INCREASED MORTALITY
                           ALTERED CHEMISTRIES
                                                                     3E+0
                                                                     300
                                                            4E-4
                                                            1000
                                                                     5E-4
                                                                     1000
                                                                                                            IRIS
                                                                                          IRIS
                                                                                5E-4
                                                                                1000
                                                                                           010166
                               005170
                               005174
        SUBCHRONIC  [RfD] COMMENT:  CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.
        CHRONIC  [RfD] COMMENT:   CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING  FOR DIFFERENCES  IN  MOLECULAR WEIGHT.
ANTIMONY  POTASSIUM TARTRATE
LOAEL   0.91  MG/KG/DAY     RAT
        ORAL:  DRINKING     LIFETIME
        WATER
                                      000304-61-0
                             WHOLE BODY
                             BLOOD
                           INCREASED MORTALITY
                           ALTERED CHEMISTRIES
                                                            9E-4
                                                            1000
                     9E-4
                     1000
                                                                                                                      005234
        SUBCHRONIC  [RfD] COMMENT:  CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.
        CHRONIC  [RfD] COMMENT:   CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING  FOR DIFFERENCES  IN  MOLECULAR WEIGHT.
ANTIMONY  TETROXIDE
LOAEL
0.44 MG/KG/DAY
ORAL: DRINKING
WATER
RAT
LIFETIME
001332-81-6

  WHOLE BODY
  BLOOD
                                                     INCREASED MORTALITY
                                                     ALTERED CHEMISTRIES
4E-4
1000
4E-4
1000
                                                                                                                              005238
        SUBCHRONIC  [RfD] COMMENT:  CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.
        CHRONIC  [RfD] COMMENT:   CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING  FOR DIFFERENCES  IN  MOLECULAR WEIGHT.
ANTIMONY  TRIOXIDE
LOAEL   0.42  MG/KG/DAY
        ORAL:  DRINKING
        WATER
                  RAT
                  LIFETIME
          001309-64-4

           WHOLE BODY -
           BLOOD
                  INCREASED MORTALITY
                  ALTERED CHEMISTRIES
                                                            4E-4
                                                            1000
                     4E-4
                     1000
                                                                                                                      005242
        SUBCHRONIC  [RfD] COMMENT:  CALCULATED BY  ANALOGY TO ANTIMONY BY CORRECTING  FOR DIFFERENCES  IN MOLECULAR WEIGHT.
        CHRONIC [RfD] COMMENT:   CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING  FOR DIFFERENCES IN  MOLECULAR WEIGHT.
IRIS,  ERA'S  INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                                  1-6

-------
                          HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
                                                                                                                                   January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                          SPECIES
                     EXPERIMENT LENGTH TARGET
                                                      CRITICAL EFFECT
                                                               SiiKhronic             Chronic
                                                            [RfC]      [RfO]       [RfC]       [RfO]     REFERENCE
                                                          (mg/cu m)  (mg/kg/day) (mg/cu m)  (cnq/kq/day)
                                                              UF         UF        UF         UF
ARAMITE
NOAEL   100     PPM
        ORAL:  DIET
                                    000140-57-8
NOAEL
                          RAT
                          104 WEEKS
                                      LIVER            INCREASED WEIGHT

        CHRONIC [RfD] COMMENT:  UNDER REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.
        500     PPM
        ORAL: DIET
DOG
52 WEEKS
                                      LIVER
DEGENERATION
1E-1
100
                                                                                           5E-2
                                                                                           100
                                                                                                                                005850
                                                                          005849
        GENERAL COMMENT:  ALSO SEE HEAST  TABLE 3: CARCINOGENICITY.

                                    007440-38-2
ARSENIC,  INORGANIC
NOAEL   0.009 MG/L         HUMAN
        ORAL
                                      SKIN
                                      SKIN
                            KERATOSIS
                            HYPERPIGMENTATION
        SUBCHRONIC  [RfD] COMMENT:  THE  CHRONIC ORAL [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST  TABLE 3: CARCINOGENICITY.
ATRAZINE
NOEL    10       PPM
        ORAL: DIET
                                    001912-24-9
                          RAT
                                      PUPS
                            DECREASED WEIGHT
                                           3E-4
                                           3
                                                                      5E-3
                                                                      100
                                                                                                                     IRIS
                                                                                                                      IRIS
                                                                                                                                010434
                                                                                                                                010435
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  [RfD]  WAS DETERMINED FROM A TWO-GENERATION REPRODUCTION STUDY WITH EXPOSURES PRIOR TO MATING.
BARIUM
NOAEL   0.21  MG/KG/DAY

        ORAL: WATER
                                   007440-39-3
                          HUMAN
                          10 WEEKS
            CARDIOVASCULAR
            SYSTEM
                            INCREASED BLOOD PRESSURE
                                                                      7E-2
                                                                      3
                                                                                                                      IRIS
                                                                          010348
        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        SUBCHRONIC [RfC] COMMENT:  ALSO SEE  HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY)
        CHRONIC [RfC]  COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION: IRIS USER SUPPORT: (513)  569-7254, FTS 684-7254.
                                                                                                                                            1-7

-------
                         HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)      January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
                                                  Subchronic             Chronic
                                               [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
                                             (mg/cu m) (na/kg/day) (cng/cu m)  (mg/kg/day)
                                                                                      UF
                                                                                                 UF
                                                                                                          UF
                                                                                                                     UF
BARIUM CYANIDE
NOAEL    0.21    MG/KG/DAY   HUMAN
        ORAL: WATER
               000542-62-1

                 CARDIOVASCULAR
                 SYSTEM
                                                     INCREASED BLOOD PRESSURE
                                                         1E-1
                                                         3
        CHRONIC  [RfD]  COMMENT:  WITHDRAWN FROM IRIS (3/1/91). UNDER  REVIEW, NUMBER SUBJECT TO CHANGE.

BENEFIN                          001861-40-1
NOAEL    25      MG/KG/DAY  DOG
        ORAL: DIET        1 YEAR      ERYTHROCYTE     DECREASED COUNT

        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

BENZAL CHLORIDE                000098-87-3
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                          3E-1
                                                                          100
BENZALDEHYDE
NOEL     200  MG/KG/DAY     RAT
        ORAL: GAVAGE       13 WEEKS
               000100-52-7

                 KIDNEY
                 FORESTOMACH
                                                    EFFECTS
                                                    LESIONS
                                                         1E+0
                                                         100
BENZALDEHYDE  CYANOHYDRIN          000532-28-5
        DATA  INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
BENZIDINE
LOAEL    2.7 MG/KG/DAY

        ORAL: DRINKING
        WATER
               000092-87-5
      MOUSE
      33 MONTHS
BRAIN
LIVER
CELLULAR CHANGES
CELLULAR CHANGES
3E-3
1000
                                                              1E-1
                                                              3
                                                                              IRIS
                                                              IRIS
                                                                    IRIS
                                                                              IRIS
        SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC  [RfC] COMMENT:  THE CHRONIC INHALATION  [RfC] IS CONSIDERED NOT VERIFIABLE (7/1/91) BY THE RfD/RfC WORKGROUP.
        GENERAL  COMMENT:   ALSO SEE HEAST  TABLE 3: CARCINOGENICITY.
BENZOIC ACID
NOAEL    312     MG/DAY
        ORAL: DIET
               000065-85-0
      HUMAN
                                                    NONE OBSERVED
                                                         4E+0
                                                         1
                                                                                               IRIS
                               010393
                                                                        005852
                                                                                                         005853
                               005854
                                                                                                         005781
                                                                                        005830
                                                                                                         005260
        SUBCHRONIC [RfD]  COMMENT:  THE HUMAN DAILY PER  CAPITA INTAKE WAS USED AS THE CRITICAL DOSE LEVEL.   THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE
                                 SUBCHRONIC  [RfD].
        CHRONIC  [RfD] COMMENT:  THE HUMAN DAILY PER CAPITA INTAKE WAS USED AS THE CRITICAL DOSE  LEVEL.
IRIS,  EPA'S INTEGRATED  RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                     1-8

-------
                         HEAST TABLE  1:  SUBCHRONIC  AND  CHRONIC TOXICITY  (OTHER THAN  CARCIN06ENICITY)       January 1992
CHEMICAL  DOSE            SPECIES
LEVEL     ROUTE      EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
                                                  Subchronic             Chronic
                                               [RfC]      [RfD]      [RfC]       [RfO]     REFERENCE
                                             (mg/cu n) (ro/kg/day) (na/cu m)   (na/kg/day)
                                                 UF         UF        UF         UF
BENZYL ALCOHOL
NOAEL    143 MG/KG/DAY
                                   000100-51-6
                         RAT
                                                    DECREASED WEIGHT
        ORAL: GAVAGE       13 WEEKS    WHOLE BODY

LOAEL    286 MG/KG/DAY
                          RAT
        ORAL: GAVAGE       103 WEEKS   FORESTOMACH     EPITHELIAL  HYPERPLASIA
                                                                                              1E+0
                                                                                              100
                                                                                                                  3E-1
                                                                                                                  1000
                                                                                                                            005856
                                                                                        005855
BERYLLIUM
NOAEL    0.54 MG/KG/DAY

        ORAL: DRINKING
        WATER
                                   007440-41-7
                          RAT
                          LIFETIME
                NONE OBSERVED
        SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
        GENERAL COMMENT:   ALSO SEE HEAST  TABLE 3: CARCINOGENIC1TY.
BIPHENYL,  1,1'-
NOAEL   50 MG/KG/DAY

        ORAL: DIET
                                   000092-52-4
                          RAT
                          700 DAYS
KIDNEY
                DAMAGE
                                                         5E-3
                                                         100
                                                         5E-2
                                                         1000
                                                                                                                  IRIS
          005262
                                                                                                        IRIS
                                                                                                                  IRIS
                                                                                                                            005857
        SUBCHRONIC  [RfD]  COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC  [RfC] COMMENT:  THE CHRONIC  INHALATAION  [RfC] IS CONSIDERED NOT  VERIFIABLE (11/1/90) BY THE RfD/RfC WORKGROUP.
BIS(Z-CHLOROISOPROPYL)  ETHER
NOAEL   35.8   MG/KG/DAY  MOUSE
        ORAL:  DIET         2  YEARS     ERYTHROCYTES
                                               039638-32-9

                                                     DECREASED HEMOGLOBIN

        GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGEN I CITY.

                                            000117-81-7
                                                         4E-2
                                                         1000
IRIS
          010257
BIS(2-ETHYLHEXYL)PHTHALATE
LOAEL   19  MG/KG/DAY
                          GUINEA PIG
        ORAL:  DIET         1  YEAR      LIVER
                                                     INCREASED RELATIVE WEIGHT
                                                                                              2E-2
                                                                                              1000
                                                                              IRIS
                                                                                        005612
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS, EPA'S  INTEGRATED RISK  INFORMATION  SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT: (513)  569-7254, FTS 684-7254.
                                                                                                                                        1-9

-------
                         HEAST TABLE 1:  SUBCHRONIC  AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                      January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                 SPECIES
            EXPERIMENT LENGTH TARGET
                                                   CRITICAL EFFECT
                                                            Subchronic             Chronic
                                                         [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
                                                        (mg/cu m) (mg/kg/day)  (mg/cu m)  (mg/kg/day)
                                                                                    UF
                                                                                        UF
                                                                               UF
BISPHENOL  A
LOAEL    50 MG/KG/DAY
                           000080-05-7


tlOAEL

BORON
LOAEL




ORAL
750 PPM
ORAL

4.5 MG/CU M
INHALATION:
INTERMITTENT

RAT
103 WEEKS
RAT
13 WEEKS

HUMAN




WHOLE BODY

WHOLE BODY
007440-42-8

RESPIRATORY
TRACT
BRONCHUS

DECREASED WEIGHT

DECREASED WEIGHT


IRRITATION

BRONCHITIS
                                 UF
                                                                                                                 IRIS
                                                                                            6E-1
                                                                                            100
                                                                                  2E-2
                                                                                  100
                                                                                               2E-2
                                                                                               100
        SUBCHRONIC [RfC] COMMENT:  THE SUBCHRONIC [RfC]  IS SPECIFICALLY FOR  ANHYDROUS BORAX.
        CHRONIC [RfC] COMMENT:  THE CHRONIC  [RfC] IS SPECIFICALLY  FOR ANHYDROUS BORAX.
NOAEL
                         DOG
                         2 YEARS
8.8 MG/KG/DAY

ORAL: DIET        2 YEARS    TESTIS          LESIONS

SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL [RfD]  WAS ADOPTED  AS THE SUBCHRONIC ORAL  [RfD].

                           007637-07-2

                            KIDNEY          NECROSIS
                                                                   9E-2
                                                                   100
                               IRIS
BORON  TRIFLUORIDE
NOAEL    6       MG/CU M
        INHALATION:
        INTERMITTENT
RAT
13 WEEKS
7E-3
300
7E-4
3000
BROMINATED DIBENZO-P-DIOXINS
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

BROMINATED DIBENZOFURANS
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

BROMOACETONE                   000598-31-2
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

BROMOCHLOROETHANES
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                   005268
                                                                                                                   005266
                                                                                                 005269
                     005272
                                                                                                 010395
                                                                                                                   005858
                                                                                                                   005859
                                                                                                                   005860
                                                                                                                   005861
IRIS, EPA'S INTEGRATED RISK INFORMATION  SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                              1-10

-------
                         HEAST TABLE  1:  SUBCHRONIC  AND  CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                                        January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                  SPECIES
            EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
                                                                               Sifcchronic             Chronic
                                                                            [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
                                                                          (mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                                                     UF
BROMODICHLOROMETHANE
LOAEL    17.9 MG/KG/DAY
                           000075-27-4
        ORAL: GAVAGE
                  MOUSE
                  102 WEEKS
                                    KIDNEY
                                                    CYTOMEGALY
                                                                                                UF
                                                                                      2E-2
                                                                                      1000
        SUBCHRONIC [RfD]  COMMENT:  THE  CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
        GENERAL COMMENT:   ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
BROMOFORM
NOEL    17.9 MG/KG/DAY
                           000075-25-2
                         RAT
                         13 WEEKS
BROMOMETHANE
LOAEL    26.6
ORAL:  GAVAGE       13 WEEKS    LIVER            EFFECTS

GENERAL  COMMENT:  ALSO SEE HEAST  TABLE 3: CARCINOGENICITY.

                           000074-83-9

                             NERVOUS SYSTEM   NEUROTOXICITY
                                                                                      2E-1
                                                                                      100
                  PPM
LOAEL
INHALATION:
INTERMITTENT

0.3       PPM
INHALATION:
INTERMITTENT
                         RABBIT
                         8 MONTHS
6E-2
300
                         RAT
                         29 MONTHS
                                    NASAL CAVITY
                                                    LESIONS
NOAEL
CHRONIC  [RfC] COMMENT:  UNDER REVIEW, CURRENT  NUMBER SUBJECT TO CHANGE.

1.4 MG/KG/DAY
                  RAT
ORAL:  GAVAGE       13 WEEKS    FORESTOMACH      HYPERPLASIA
                                                                                                         UF
                                                                                                                     UF
                                                                                                                  IRIS
                                         005718
                                                                                                          IRIS
                                         005722
                                                                                                5E-3
                                                                                                 100
                                                                                                                    005863
                                        905863
                                                                                              1.4E-2
                                                                                              100
                                                                                                          IRIS
BROMOPHENYL  PHENYL  ETHER,4-           000101-55-3
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                    005862
                                                                                                                    005864
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                               1-11

-------
                         HEAST  TABLE  1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                               January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                         SPECIES
                    EXPERIMENT LENGTH TARGET
BROMOPHOS                        002104-96-3
NOAEL    5       MG/KG/DAY  RAT
        ORAL: DIET        3 GENERA-   BLOOD
                         T10NS
                                    LIVER
                                                    CRITICAL EFFECT
                                                    DECREASED CHOLINESTERASE
                                                    ACTIVITY
                                                    DECREASED CHOLINESTERASE
                                                    ACTIVITY
    Sifcchronic             Chronic
  [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
(cng/cu m) (mq/kg/day) (mg/cu m)  (mg/kg/day)
                                                                                     UF
        SUBCHRONIC [RfD] COMMENT:   BASED ON A REPRODUCTION STUDY.
        CHRONIC [RfD]  COMMENT:  BASED ON A REPRODUCTION STUDY.
BROMOXYNIL
NOEL     5 MG/KG/DAY
                                   001689-84-5
                         RAT
                         2 YEARS
        ORAL: DIET

        SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL  [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

BROMOXYNIL OCTANOATE          001689-99-2
NOEL     7.3 MG/KG/DAY
                         RAT
        ORAL: DIET        2 YEARS

        SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL  [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

BUSAN  77                         031512-74-0
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT

BUSAN  90                         002491-38-5
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
BUTANOL,  1-
NOAEL    125     MG/KG/DAY  RAT
        ORAL: GAVAGE      13 WEEKS
                                   000071-36-3

                                    CENTRAL NERVOUS  HYPOACTIVITY
                                    SYSTEM
                                    CENTRAL NERVOUS  ATAXIA
                                    SYSTEM
                                                                                                UF
            5E-2
            100
                                                                                                         UF
            2E-2
            300
                                                                                             2E-2
                                                                                             300
            1E+0
            100
                                                                                                                    UF
5E-3
1000
                                                                                                                            005865
                                                                                                                  IRIS
                                                                                                                            005866
                                IRIS
                                          005867
IRIS
                                                                                                                            005868
                                                                                                                            005869
          005870
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                       1-12

-------
                         HEAST TABLE  1:  SUBCHRONIC  AND  CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
                                                                                                                                January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
                         SPECIES
                    EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
                                                             Subchronic             Chronic
                                                          [RfC]      [RfO]       [RfC]       [RfD]     REFERENCE
                                                         (mg/cu m)  (mg/kg/day) (mg/cu ro)  (mg/kg/day)
                                                                                     UF
BUTYL  BENZYL  PHTHALATE,  N-
NOAEL    159 MG/KG/DAY
                         RAT
        ORAL: DIET        26 WEEKS
                                           000085-68-7
                                     LIVER           ALTERED WEIGHT

        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.

                                   002008-41-5

                                                    INCREASED RELATIVE WEIGHT

        SUBCHRONIC [RfD]  COMMENT:  THE  CHRONIC ORAL  [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfO].
BUTYLATE
NOEL     5  MG/KG/DAY
        ORAL: CAPSULE
DOG
12 MONTHS   LIVER
                                                                                                UF
                                                                                              2E+0
                                                                                              100
5E-2
100
                                                                                                          UF
                                                                                                                     UF
                                                                                         IRIS
                                                                                         IRIS
BUTYLCHLORIDE, t-             000507-20-0
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

BUTYROLACTONE, GAMMA-        000096-48-0
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CACODYLIC  ACID
NOEL     9.2  MG/KG/DAY    RAT
        ORAL: DIET        90 DAYS
                                   000075-60-5
                                                    NONE OBSERVED
                                                                    3E-2
                                                                    300
                    3E-3
                    3000
                                                                                                   005616
                                                                                                   005871
                                                                                                                            005810
                                                                                                                            005872
                                                                                                                            005873
        SUBCHRONIC [RfD]  COMMENT:  CALCULATED BY ANALOGY TO ARSENIC BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
        CHRONIC  [RfD]  COMMENT:  CALCULATED BY ANALOGY  TO ARSENIC BY CORRECTING  FOR DIFFERENCES IN MOLECULAR WEIGHT.  UNDER REVIEW,  CURRENT NUMBER
                              SUBJECT  TO CHANGE.
CADMIUM
                                   007440-43-9
                                                                                                                  IRIS
                                                                                                                            005280
        CHRONIC  [RfD]  COMMENT:  TWO SEPARATE REFERENCE DOSES VERIFIED FOR FOOD AND WATER.
        SUBCHRONIC [RfD]  COMMENT:  BECAUSE OF BACKGROUND DIETARY EXPOSURE, AN ORAL SUBCHRONIC  [RfD] WAS NOT ESTIMATED.
        CHRONIC  [RfC]  COMMENT:  UNDER  REVIEW.
        GENERAL  COMMENT:   ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS,  EPA'S  INTEGRATED  RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT: (513) 569-7254,  FTS 684-7254.
                                                                                                                                       1-13

-------
                          HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)       January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
                                                      CRITICAL EFFECT
                                                     Sifcchronic             Chronic
                                                  [RfC]       [RfD]      [RfC]       [RfD]     REFERENCE
                                                (mg/cu m) (mg/kg/day) (mg/cu m)   lag/kg/day)
                                                    UF         UF        UF         UF
CALCIUM  CYANIDE
NOAEL   19.1    MG/KG/DAY  RAT
        ORAL:  DIET         2 YEARS
               000592-01-8

                 WHOLE  BODY
                 THYROID
                 NERVE
                  DECREASED WEIGHT
                  EFFECTS
                  MYEL1N DEGENERATION
4E-2
500
                                                                                  IRIS
           010258
        SUBCHRONIC  [RfD] COMMENT:  CALCULATED BY ANALOGY TO  FREE CYANIDE BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.  THE CHRONIC ORAL  [RfD]
                                  WAS  ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.
CAPROLACTAM
               000105-60-2
NOAEL 50 MG/KG/DAY
ORAL: DIET
CAPTAFOL
LOAEL 2 MG/KG/DAY
ORAL: CAPSULE
RAT
90 DAYS KIDNEY
002425-06-1
DOG
12 MONTHS KIDNEY
BLADDER
EFFECTS
EFFECTS
EFFECTS
        SUBCHRONIC  [RfD] COMMENT:   THE  CHRONIC ORAL [RfD]  WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
        GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CAPTAN
NOEL    12.5 MG/KG/DAY
        ORAL: DIET
      RAT
000133-06-2

  WHOLE BODY
                                 DECREASED  WEIGHT
        SUBCHRONIC  [RfD] COMMENT:   THE  CHRONIC ORAL [RfD]  WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
        CHRONIC  [RfD] COMMENT:  BASED ON A MULTI-GENERATION REPRODUCTION STUDY.
        GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CARBARYL
NOAEL   9.6 MG/KG/DAY

        ORAL:  DIET
               000063-25-2
      RAT
      2 YEARS
                                      KIDNEY
                                      LIVER
                                 TOXICITY
                                 TOXICITY
                                                                                                5E-1
                                                                                                100
                                                                                                2E-3
                                                                                                1000
1.3E-1
100
                                                             1E-1
                                                             100
                                                                                                                     IRIS
                                                                                                 IRIS
                                                                                            005284

                                                                                            005282



                                                                                            005874
                                                                                                 IRIS
          005875
           IRIS
IRIS
005876
        SUBCHRONIC  [RfD] COMMENT:   THE  CHRONIC ORAL [RfD]  WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
        CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION  [RfC]  IS CONSIDERED NOT VERIFIABLE (11/1/91) BY THE RfD/RfC  WORKGROUP.
IRIS,  ERA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS  UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                      1-14

-------
                          HEAST TABLE  1: SUBCHRONIC  AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                                 January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                          SPECIES
                    EXPERIMENT LENGTH TARGET
                                                     CRITICAL  EFFECT
                                                              Subchronic             Chronic
                                                           [RfC]      [RfD]      [RfC]        [RfO]     REFERENCE
                                                         (mg/cu m) (TO/kg/day)  (mg/cu m)  (mg/kg/day)
                                                             UF         UF       UF         UF
CARBOFURAN
NOEL    0.5  MG/KG/DAr     DOG
        ORAL:  DIET         1  YEAR
                                   001563-66-2

                                     BLOOD
                                     TESTIS
                                     UTERUS
                           CHOLINESTERASE INHIBITION
                           EFFECTS
                           EFFECTS
                                                                     5E-3
                                                                     100
                               IRIS
                                         005877
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].

                                   000075-15-0

                          RABBIT
CARBON DISULFIDE
NOEL    11  MG/KG/DAY
        INHALATION:
        INTERMITTENT
                                     FETUS
                                                     TOXICITY
                                                                                               1E-1
                                                                                               100
                                                                                          IRIS
                                                                                                    010259
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL  [RfD] WAS DETERMINED FROM A TERATOLOGY STUDY  WITH EXPOSURES  BEFORE AND DURING THE ENTIRE  GESTATION
                               PERIOD.         .                   •  •
NOAEL
        10 MG/CU M
        INHALATION:
        INTERMITTENT
RAT
GESTATION
                                                                                                                              010430
                                     FETUS
                                                     TOXICITY
1E-2
1000
1E-2
1000
        SUBCHRONIC  [RfC] COMMENT:  THE CHRONIC INHALATION [RfC]  WAS ADOPTED AS  THE SUBCHRONIC INHALATION [RfC].
        CHRONIC  [RfC] COMMENT:   UNDER REVIEW,  CURRENT NUMBER SUBJECT TO CHANGE.

CARBON MONOXIDE               000630-08-0
        CHRONIC  [RfC] COMMENT:   REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
CARBON TETRACHLORIDE
NOAEL   0.71  MG/KG/DAY
                                    000056-23-5
                          RAT
                          12 WEEKS
        ORAL:  GAVAGE       12 WEEKS    LIVER           LESIONS

        GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.

                                    000075-87-6

                                     LIVER
CHLORAL
LOAEL   15.7 MG/KG/DAY
        ORAL: DRINKING
        WATER
MOUSE
90 DAYS
                                                     EFFECTS
                                                                     7E-3
                                                                     100
          2E-2
          1000
                                                                                                                    IRIS
                                                                                                                              910430
                                                                                                                              005288
                                                                                          IRIS
                                                                                                    005290
        SUBCHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                         1-15

-------
                         HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)       January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
                                                   CRITICAL EFFECT
                                                                                    Subchronic             Chronic
                                                                                  [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
                                                                                Cmg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                                                   UF         UF       UF         UF
CHLORDANE
NOEL     0.055 MG/KG/DAY

        ORAL: DIET
               000057-74-9
     RAT
     130 WEEKS
                                    LIVER
                                                   HYPERTROPHY
                                                                                           6E-5
                                                                                           1000
IRIS
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL  [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
        CHRONIC [RfD] COMMENT:  UNDER REVIEW.
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
CHLORINE CYANIDE
NOAEL    25.3    MG/KG/DAY  RAT
        ORAL: DIET         2 YEARS
               000506-77-4

                WHOLE  BODY
                THYROID
                NERVE
                                                   DECREASED WEIGHT
                                                   EFFECTS
                                                   MYELIN DEGENERATION
                                                                                           5E-2
                                                                                           500
IRIS
CHLORO-M-CRESOL,  P-
NOAEL    200     MG/KG/DAY  RAT
        ORAL: GAVAGE       28 DAYS
                                                                        2E+0
                                                                        100
       SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL  [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

                                  000059-50-7

                                    WHOLE BODY       DECREASED WEIGHT GAIN

CHLORO-1.3-BUTADIENE,  2-    000126-99-8

       GENERAL COMMENT:  SEE  HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

CHLOROACETALDEHYDE            000107-20-0
       DATA INADEQUATE FOR  QUANTITATIVE RISK ASSESSMENT
CHLOROACETIC ACID
LOAEL   30  MG/KG         RAT
       ORAL: GAVAGE       13 WEEKS
               000079-11-8

                HEART           MYOCARDITIS
                                                                                           2E-2
                                                                                           1000
2E-3
10000
CHLOROANILINE,  2-             000095-51-2
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

CHLOROANILINE,  3-             000108-42-9
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005296
010261
          005366
                                                                                                                         005342
005346
                                                                                                      005347
                                                                                                                         005348
IRIS, EPA'S INTEGRATED RISK  INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                1-16

-------
                          HEAST  TABLE  1: SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)       January 1992

                                                                                        Subchronic             Chronic
CHEH1CAL  DOSE             SPECIES                                                     [RfCD      [RfD]       [RfC]       [RfD]     REFERENCE
LEVEL     ROUTE     EXPERIMENT LENGTH TARGET          CRITICAL EFFECT                (mg/cu m)  (na/kg/day) (mg/cu m)  (mg/kg/dav)
                                                                                       UF         UF       UF         UF


CHLOROANILINE,  4-              000106-47-8
LOAEL   12.5 MG/KG/OAY
                          RAT       SPLEEN          PROLIFERATE LESIONS                      4E-3                 IRIS      005349
        ORAL: DIET          78 WEEKS                                                            3000

        SUBCHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

CHLOROBENZENE                   000108-90-7
NOAEL   19.5 MG/KG/DAY
                          DOG                                                                  2E-1                 IRIS       005354
        ORAL: CAPSULE      90 DAYS     LIVER           EFFECTS                                   100

        SUBCHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        SUBCHRONIC  [RfC] COMMENT:   ALSO SEE HEAST  TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC [RfC] COMMENT:  ALSO  SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

CHLOROBENZILATE                000510-15-6
NOEL    5    MG/KG/DAY     RABBIT                                                                2E-2                 IRIS       010260
        ORAL: GAVAGE       13 DAYS     GASTROINTES-     DECREASED STOOL QUANTITY                    300
                                     TINAL SYSTEM
                                     WHOLE BODY       DECREASED FOOD CONSUMPTION
                                     WHOLE BODY       DECREASED WEIGHT GAIN
                                     NERVOUS SYSTEM   HYPERIRRITABILITY

        SUBCHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC [RfD] COMMENT:  BASED ON A TERATOLOGY STUDY WITH EXPOSURES DURING DAYS 7-19 OF GESTATION.

CHLOROBENZOIC  ACID,  P-       000074-11-3
NOAEL   26 MG/DAY          RAT                                                                  2E+0                 2E-1       005360
        ORAL: DIET         5 MONTHS                                                             100                  1000

CHLOROBENZOTRIFLUORIDE,  4-           000098-56-6
NOAEL   15      MG/KG/DAY  RAT                                                                  2E-1                 2E-2       005364
        ORAL: GAVAGE                  KIDNEY          TUBULAR DEGENERATION                       100                  1000

        SUBCHRONIC  [RfD] COMMENT:   BASED ON A 2-GENERATION REPRODUCTION STUDY WITH  EXPOSURES 4 WEEKS PRIOR TO MATING, DURING GESTATION, AND FOR 90
                                  DAYS POST-WEANING.
        CHRONIC [RfD] COMMENT:  BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES 4 WEEKS  PRIOR TO MATING, DURING GESTATION, AND FOR 90 DAYS
                               POST-WEAN ING.
IRIS, EPA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.         1-17

-------
                         HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)      January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                        SPECIES
                   EXPERIMENT LENGTH TARGET
                                                   CRITICAL EFFECT
                                  Subchronic             Chronic
                               [RfC]      [RfD]      [RfC]       [RfO]     REFERENCE
                             (mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                                                    UF
                                                                                              UF
                                                                                                       UF
                                                                                                                  UF
CHLOROBUTANE,  1-
NOAEL    43 MG/KG/DAY

        ORAL: GAVAGE
                                  000109-69-3
                         RAT
                         103 WEEKS
NOAEL
       86 MG/KG/DAY

       ORAL: GAVAGE
                         RAT
                         13 WEEKS
                                    WHOLE BODY
                                    CENTRAL
                                    NERVOUS SYSTEM
                                    BLOOD
                                    CENTRAL
                                    NERVOUS SYSTEM
                                    WHOLE BODY
                                    SPLEEN

                                  000078-86-4
                                                   INCREASED MORTALITY
                                                   EFFECTS

                                                   HEMATOLOGIC EFFECTS
EFFECTS

DECREASED WEIGHT GAIN
HEMATOPOIESIS
                                                             4E-1
                                                             100
9E-1
100
CHLOROBUTANE,  2-
       DATA INADEQUATE FOR  QUANTITATIVE  RISK ASSESSMENT

CHLOROCYCLOPENTADIENE        041851-50-7
       DATA INADEQUATE FOR  QUANTITATIVE  RISK ASSESSMENT

CHLORODIBROMOMETHANE  (See  DIBROMOCHLOROMETHANE)

                                  000067-66-3
CHLOROFORM
LOAEL    12.9 MG/KG/DAY

        ORAL: CAPSULE
                         DOG
                         7.5 YEARS
                                    LIVER
                                                   LESIONS
                                         1E-2
                                         1000
                    IRIS
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
        CHRONIC [RfC] COMMENT:  UNDER REVIEW.
        GENERAL COMMENT:  ALSO SEE HEAST  TABLE 3:  CARCINOGENICITY.

CHLOROMETHANE                  000074-87-3
        DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT

        CHRONIC [RfD] COMMENT:  UNDER REVIEW.
        CHRONIC [RfC] COMMENT:  UNDER REVIEW.
        GENERAL COMMENT: FORMERLY LISTED  AS METHYL CHLORIDE..ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

CHLORONITROBENZENE,  M-       000121-73-3
        DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
                              005808
                                                                       005806
                                                                                                                         005809
                                                                                                                         005297
005372
                                                                                                                         010005
                                                                                                                          005879
IRIS,  EPA'S INTEGRATED RISK  INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                    1-18

-------
                        HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)       January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                        SPECIES
                   EXPERIKENT LENGTH TARGET
CHLOROPHENOL,  2-
NOAEL    50      PPM
        ORAL: DRINKING
        WATER
                         RAT
000095-57-8

  REPRODUCTION
                                                  CRITICAL EFFECT
                                                  REPRODUCTIVE EFFECTS
                                                  Subchronic             Chronic
                                               [RfC]      [RfDl      [RfC]       [RfO]     REFERENCE
                                             (rng/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/dav)
                                                 UF        UF       UF         UF
                                        5E-2
                                        100
                                                                                                              IRIS
                                       010436
       SUBCHRONIC  [RfO]  COMMENT:  BASED ON A REPRODUCTIVE STUDY WITH EXPOSURE 10 WEEKS PRIOR TO AND DURING MATING, GESTATION AND WEANING.
       CHRONIC [RfD] COMMENT:  BASED ON A REPRODUCTIVE STUDY WITH EXPOSURE 10 WEEKS PRIOR TO AND DURING MATING, GESTATION AND WEANING.
CHLOROPHENOL,  3-              000108-43-0
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

CHLOROPHENOL,  4-              000106-48-9
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

CHLOROPRENE (See CHLORO-1,3-BUTADIENE,2-

                                  000075-29-6
CHLOROPROPANE,  2-
NOAEL   91.4 MG/KG/DAY

       INHALATION:
       INTERMITTENT
                         RAT
                         4 WEEKS
  LIVER
EFFECTS
CHLOROPROPRENE,3-  (See  ALLYL CHLORIDE)

CHLOROTOLUENE,  M-             000108-41-8
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHLOROTOLUENE,  0-
NOAEL   20   MG/KG/DAY     RAT
       ORAL: GAVAGE       103 DAYS
                                  000095-49-8

                                   WHOLE  BODY      DECREASED WEIGHT GAIN
CHLOROTOLUENE,  P-             000106-43-4
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHLORPYRIFOS
NOEL     0.03  MG/KG/DAY
        ORAL: CAPSULE
                         HUMAN
                         20 DAYS
                         OR 9 DAYS
002921-88-2

  BLOOD
DECREASED CHOLINESTERASE
ACTIVITY
1E+0
100
                                                                  1E-1
                                                                  1000
                                                         2E-1
                                                         100
                                                            IRIS
          3E-3
          10
                                                                                                              IRIS
                                                                                                                       005309
                                                                                                                       005310
                                                                                                                       010444
                                                                                                                       005880
                                                                     010167
                                                                                                                       010200
                                                                     005881
        SUBCHRONIC  [RfD]  COMMENT:   THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].


IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                  1-19

-------
                         HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                                January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                         SPECIES
                    EXPERIMENT LENGTH TARGET
                CRITICAL EFFECT
                                  Subchronic             Chronic
                                [RfC]       [RfD]      [RfC]       [RfD]     REFERENCE
                              (mg/cu m) (tng/kg/day) (mg/cu m)  (mg/kg/day)
                                                                                      UF
                                                                                                 UF
                                                                      UF
                                                                 UF
CHLORPYRIFOS METHYL 005598-13-0
NOAEL 1 MG/KG/DAY DOG
ORAL: DIET 2 YEARS LIVER
NOAEL 1 MG/KG/DAY
ORAL: DIET
RAT
3 GENERA-
TIONS
REPRODUCTION
                                                     EFFECTS


                                                     DECREASED FERTILITY


        CHRONIC  [RfD]  COMMENT:  UNDER REVIEW, CURRENT NUMBER SUBJECT  TO CHANGE.

                                   001897-45-6
CHLORTHALONIL
NOEL     1.5  MG/KG/DAY

        ORAL: DIET
                          DOG
                          2 YEARS
KIDNEY
EFFECTS
        SUBCHRONIC [RfD]  COMMENT:  THE  CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        GENERAL COMMENT:   ALSO SEE HEAST  TABLE 3: CARCINOGENICITY.
CHLORTHIOPHOS
NOAEL    0.08 MG/KG/DAY

        ORAL: DIET

CHROMIUM  (III)
NOEL    5      %
        ORAL: DIET
                          RAT
                          2 YEARS
                          RAT
                          840 DAYS
                                   060238-56-4
                                    016065-83-1
                NONE OBSERVED
                                                                                              1E-2
                                                                                              100
1.5E-2
100
                                                          8E-4
                                                          100
                                          1E+0
                                          1000
        CHRONIC/SUBCHRONIC  [RfC] COMMENT:   INHALATION ISSUES ARE UNDER REVIEW BY THE RfD/RfC WORK GROUP
        SUBCHRONIC [RfD]  COMMENT:  THE  CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHROMIUM  (VI)
NOAEL    2.4  MG/KG/DAY

        ORAL: DRINKING
        WATER
                                   018540-29-9
                          RAT
                          1 YEAR
                                                     NONE OBSERVED
                                                          2E-2
                                                          100
        CHRONIC/SUBCHRONIC [RfC] COMMENT:   INHALATION ISSUES ARE UNDER REVIEW BY THE RfD/RfC WORK  GROUP

CHRYSENE                         000218-01-9
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
        GENERAL COMMENT:   ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                                                                              1E-2
                                                                              100
                                                                                                                             005882
                                                                                                                   IRIS
                                                                                                                             005883
                                                              8E-4
                                                              100
                                                                                                                   IRIS
                                                                                                                             005884
                                                                                                                             005731
                                                              IRIS
                               005522
                                                                                                                             005885
IRIS,  EPA'S  INTEGRATED  RISK INFORMATION SYSTEM,  IS  UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                        1-20

-------
CHEMICAL DOSE
LEVEL ROUTE
COPPER
LOAEL 5.3
ORAL
SPECIES

EXPERIMENT LENGTH TARGET
MG HUMAN
SINGLE
DOSE
007440-50-8
GASTROINTES-
TINAL SYSTEM
                          HEAST TABLE  1:  SUBCHRONIC  AND CHRONIC  TOXICITY  (OTHER THAN  CARCIN06ENICITY)       January 1992

                                                                                                                                REFERENCE
                                                      CRITICAL EFFECT
                                                      IRRITATIOM
                                                     Subchronic             Chronic
                                                  [RfC]       [RfD]      [RfC]        [RfO]
                                                 (mg/cu m) (cng/kg/day)  (mg/cu m)  (mg/kg/day)
                                                    UF          UF       UF          UF
                                                                                                 1.3 mg/l
                                                                                  1.3mg/l   005374
        CHRONIC [RfD]  COMMENT:  CURRENT DRINKING WATER STANDARD OF  1.3 MG/L. DWCD (1987)  CONCLUDED TOXICITY DATA WERE INADEQUATE FOR  CALCULATION OF
                               AN [RfD]  FOR COPPER.
        SUBCHRONIC  [RfD] COMMENT:  CURRENT DRINKING WATER STANDARD  OF 1.3 MG/L. DUCD (1987) CONCLUDED TOXICITY  DATA WERE INADEQUATE  FOR CALCULATION
                                  OF AN [RfD]  FOR COPPER.
COPPER CYANIDE
NOAEL   5       MG/KG/DAY  RAT
        ORAL:  GAVAGE       90 DAYS
CRESOL,  M-
NOAEL   50      MG/KG/DAY  RAT
        ORAL:  GAVAGE       90 DAYS
000544-92-3

  LIVER
  KIDNEY
  WHOLE BODY
  ORGANS

000108-39-4

  WHOLE BODY
  NERVOUS SYSTEM
                                                      HISTOPATHOLOGY
                                                      HISTOPATHOLOGY
                                                      DECREASED WEIGHT
                                                      DECREASED WEIGHT
                                                      DECREASED WEIGHT GAIN
                                                      NEUROTOXICITY
                                           5E-2
                                           100
                     IRIS
           010262
                                           5E-1
                                           100
                     IRIS
          005380
        CHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE  (12/11/91) BY THE  RfD/RfC WORK GROUP.
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENIC!TY.
CRESOL,  0-
NOAEL   50      MG/KG/DAY  RAT
        ORAL:  GAVAGE       90 DAYS
000095-48-7

  WHOLE BODY
  NERVOUS SYSTEM
DECREASED  WEIGHT GAIN
NEUROTOXICITY
5E-1
100
                                                                IRIS
                                                                          005384
        CHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE  (12/11/91) BY THE  RfD/RfC WORK GROUP.
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGEN I CITY.
CRESOL,  P-
NOAEL   50      MG/KG/DAY  RAT
        ORAL:  GAVAGE       90 DAYS
000106-44-5

  WHOLE BODY
  NERVOUS SYSTEM
DECREASED  WEIGHT GAIN
NEUROTOXICITY
5E-1
100
5E-2
1000
                                                                          005388
        CHRONIC [RfD]  COMMENT:  WITHDRAWN FROM  IRIS (8/1/91).  UNDER  REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
        CHRONIC [RfC]  COMMENT:  THE CHRONIC  INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE  RfD/RfC WORK GROUP.
        GENERAL COMMENT:  ALSO SEE HEAST TABLE  3: CARCINOGENICITY.
IRIS,  EPA'S  INTEGRATED RISK INFORMATION  SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254,  FTS 684-7254.
                                                                                                       1-21

-------
                          HEAST  TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN  CARCIN06ENICITY)       January 1992
CHEMICAL DOSE
LEVEL     ROUTE
                          SPECIES
                    EXPERIMENT LENGTH  TARGET
                                                      CRITICAL EFFECT
                                                               Subchronic             Chronic
                                                            [RfCJ      [RfD]       [RfC]       [RfD]     REFERENCE
                                                          (mg/cu m) (mg/kg/day) (mg/cu ro)  (mg/kg/day)
                                                                                        UF
                                                                                                   UF
                                                                                   UF
                                                                                                                UF
CUMENE
NOAEL   105.1
                PPM
        INHALATION:
        INTERMITTENT
RAT
4 WEEKS
                            000098-82-8

                                              INVOLVEMENT

                                              IRRITATION

CHRONIC [RfC] COMMENT:  UNDER REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.
                                     CENTRAL
                                     NERVOUS SYSTEM
                                     NOSE
9E-2
1000
NOAEL
        154  MG/KG/DAY
        ORAL: GAVAGE
CYANAZINE
NOEL    0.625  MG/KG/DAY

        ORAL:  DIET
RAT
194 DAYS
                          DOG
                          1 YEAR
                                     KIDNEY
                                              INCREASED WEIGHT
                                         021725-46-2
           WHOLE BODY      DECREASED WEIGHT GAIN
           BLOOD           INCREASED PLATELET  COUNT
           BLOOD           ALTERED CLINICAL CHEMISTRY
                           PARAMETERS
        SUBCHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].

                                    000057-12-5
CYANIDE  (CN-)
NOAEL   10.8   MG/KG/DAY  RAT
        ORAL:  DIET
                          104 WEEKS
                                     WHOLE BODY
                                     THYROID
                                     NERVE
                            DECREASED WEIGHT
                            EFFECTS
                            MYELIN DEGENERATION
        SUBCHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].

                                    000460-19-5
CYANOGEN
NOAEL   21.6  MG/KG/DAY    RAT
        ORAL:  DIET         2 YEARS
                                     WHOLE BODY
                                     THYROID
                                     NERVE
                            DECREASED WEIGHT
                            EFFECTS
                            MYELIN DEGENERATION
          4E-1
          300
                                                                                        2E-3
                                                                                        300
                                                                                                2E-2
                                                                                                500
                                                                                                4E-2
                                                                                                500
9E-3
10000
005908
                                                                                                                     IRIS
                                                                                                                     IRIS
                                                                                                                        005392
                                                                                                     010411
                                                                                           IRIS
                                                                                                                        005396
                                                                                           IRIS
                                                                                                     010263
        SUBCHRONIC  [RfD] COMMENT:   CALCULATED BY ANALOGY  TO  FREE CYANIDE BY  CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC ORAL [RfD]
                                  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC  [RfD] COMMENT:  CALCULATED BY ANALOGY TO  FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR  WEIGHT.
IRIS,  EPA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS  UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                                           1-22

-------
                         HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER  THAN CARCIN06ENICITY)       January 1992

                                                                                       Subchronic             Chronic
CHEMICAL  DOSE            SPECIES                                                    [RfC]      [RfO]      [RfC]       [RfO]     REFERENCE
LEVEL     ROUTE      EXPERIMENT LENGTH TARGET          CRITICAL EFFECT                (mg/cu m) (mq/kq/day) (mg/cu m)   (mg/kg/day)
                                                                                      UF         (If        UF         UF


CYANOGEN  BROMIDE               000506-68-3
NOAEL   44      MG/KG/DAY  RAT                                                                  9E-2                IRIS      010264
        ORAL: DIET        2 YEARS     WHOLE BODY      DECREASED WEIGHT                           500
                                     THYROID         EFFECTS
                                     NERVE           MYELIN DEGENERATION

        SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC ORAL [RfD]
                                 WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].
        CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY  TO FREE CYANIDE  BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.

CYCLOATE                         001134-23-2
        DATA  INADEQUATE  FOR QUANTITATIVE  RISK ASSESSMENT                                                                        005886

        CHRONIC [RfO] COMMENT:  UNDER REVIEW.

CYCLOHEXANOL                    000108-93-0
        DATA  INADEQUATE  FOR QUANTITATIVE  RISK ASSESSMENT                                                                        005887

CYCLOHEXYLAMINE                000108-91-8
                                                                                                                  IRIS      005400

NOAEL   30      MG/KG/DAY  RAT                                                                  3E-1                           005398
        ORAL: DIET        90 DAYS     WHOLE BODY      DECREASED WEIGHT GAIN                      100
                                     TEST IS          DECREASED WEIGHT

CYCLOPENTADIENE                000542-92-7

        GENERAL COMMENT:  ALSO SEE HEAST  TABLE 2: ALTERNATE METHODS -  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

DACTHAL                          001861-32-1
NOEL    50    MG/KG/DAY     RAT                                                                  5E-1                 IRIS      005888
        ORAL: DIET        2 YEARS     KIDNEY          INCREASED WEIGHT                           100
                                     ADRENAL         INCREASED RELATIVE WEIGHT

        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED  AS THE SUBCHRONIC ORAL [RfD].
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT: (513)  569-7254, FTS 684-7254.         1-23

-------
                         HEAST  TABLE  1: SUBCHRONIC  AND  CHRONIC  TOXICITY  (OTHER THAN  CARCINOGENICITY)      January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
                                  Sifcchronic             Chronic
                               [RfC]      [RfO]       [RfC]       [RfO]     REFERENCE
                              (mg/cu ro) (mg/lcg/day) (mg/cti ro)  (mg/kg/day)
                                 UF         UF       UF         UF
DALAPON
NOEL    8.45  MG/KG/DAY    RAT
        ORAL: DIET        2 YEARS
               000075-99-0

                 KIDNEY           INCREASED  RELATIVE UEIGHT
                                         3E-2
                                         300
                    IRIS
          005889
        SUBCHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO DALAPON SODIUM BY CORRECTING  FOR DIFFERENCES IN MOLECULAR WEIGHT.  THE CHRONIC ORAL  [RfD]
                                 WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC [RfD]  COMMENT:  CALCULATED BY ANALOGY TO DALAPON SODIUM BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.

DB,2,4-  (See  DICHLOROPHENOXY)BUTYRIC  ACID,4(2,4-)

                                   000050-29-3
DDT
NOEL



0.05 MG/KG/DAY

ORAL: DIET


RAT
27 WEEKS
                                    LIVER
                                                    LESIONS
        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
DECABROMODIPHENYL ETHER
NOEL    1    MG/KG/DAY    RAT
        ORAL: DIET        2 YEARS
               001163-19-5

                 LIVER
                                                    INCREASED WEIGHT
        SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
DIAZINON
NOAEL    0.09 MG/KG/DAY

        ORAL: DIET
               000333-41-5
      RAT
      35-42 DAYS  BLOOD
DECREASED CHOLINESTERASE
ACTIVITY
        CHRONIC  [RfD]  COMMENT:  UNDER  REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.

DIBENZOFURAN                   000132-64-9
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
DIBROMOBENZENE,  1,4-
NOAEL   10     MG/KG/DAY   RAT
        ORAL: GAVAGE       45 OR 90
                          DAYS
               000106-37-6

                 LIVER
                 LIVER
INCREASED RELATIVE  WEIGHT
ALTERED ENZYME ACTIVITIES
                                                                          5E-4
                                                                          100
                                          1E-2
                                          100
9E-4
100
                                          1E-1
                                          100
                                                                                                                  IRIS
                                                                        005408
                    IRIS
          005891
9E-4      005892
100
                     IRIS
                                                                                                        005409
          005893
IRIS,  EPA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER  INFORMATION: IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                   1-24

-------
                         HEAST TABLE  1:  SUBCHRONIC  AND  CHRONIC  TOXICITY  (OTHER THAN  CARCIN06ENICITY)      January 1992

                                                                                      Subchronic             Chronic
CHEMICAL  DOSE            SPECIES                                                   [RfC]       [RfO]       [RfC]       [RfO]     REFERENCE
LEVEL     ROUTE      EXPERIMENT LENGTH TARGET          CRITICAL EFFECT                (mg/cu m) (mg/kg/day) (na/cu m)  (mg/kg/day)
                                                                                     UF         UF       UF         UF


DIBROMOCHLOROMETHANE         000124-48-1
NOEL    21.4 MG/KG/DAY
                         RAT                                                                  2E-1                 IRIS      005894
        ORAL: GAVAGE      13 WEEKS    LIVER           LESIONS                                   100
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.

DIBUTYL  PHTHALATE             000084-74-2
NOAEL   125 MG/KG/DAY     RAT                                                                  1E+0       IRIS       IRIS      005622
        ORAL: DIET        52 WEEKS    WHOLE BODY       INCREASED MORTALITY                         100

        CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION  [RfC]  IS CONSIDERED NOT VERIFIABLE (10/1/90)  BY THE RfD/RfC WORKGROUP.

DICHLOROBENZENE,  1,2-        000095-50-1
NOAEL   89  MG/KG/DAY      RAT                                                                  9E-1                 IRIS      005828
        ORAL: GAVAGE      13 WEEKS    LIVER           EFFECTS                                   100

        SUBCHRONIC [RfC]  COMMENT:   ALSO SEE HEAST  TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
        CHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

DICHLOROBENZENE,  1,3-        000541-73-1
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT                                                                       005414

DICHLOROBENZENE,  1,4-        000106-46-7
NOAEL   454.6   MG/CU M   RAT                                                       7E-1                 7E-1                005787
        INHALATION:       76 WEEKS    LIVER           EFFECTS                        100                  100
        INTERMITTENT
                                     KIDNEY          EFFECTS

        SUBCHRONIC [RfC]  COMMENT:   THE CHRONIC INHALATION [RfC]  WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
        CHRONIC [RfC] COMMENT:  UNDER REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.

DICHLOROBUTENES
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT                                                                       005415
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.         1-25

-------
                          HEAST TABLE  1: SUBCHRONIC  AND  CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
                                                                                                              January 1992
CHEMICAL DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
     Subchronic             Chronic
  [RfC]      [RfD]      [RfC]       [RfO]     REFERENCE
(mg/cu m) (mg/kg/day)  (mg/cu m)  (mg/kg/day)
    UF         UF       UF          UF
DICHLORODIFLUOROMETHANE
NOAEL   90     MG/KG/DAY  DOG
        ORAL:  DIET         90 DAYS
               000075-71-8
                                 NONE OBSERVED
                                          9E-1
                                          100
                                                                                                                    IRIS
                                           005496

                                           005498
        SUBCHRONIC  [RfC]  COMMENT:  ALSO SEE HEAST  TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC  [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY)
DICHLOROETHANE,  1,1-
NOEL    115 MG/KG/DAY
               000075-34-3
        INHALATION:
        INTERMITTENT
                          RAT
                          13 WEEKS
                                                     NONE OBSERVED
                                                                           1E+0
                                                                           100
                                                               1E-1
                                                               1000
                                           005790
        SUBCHRONIC  [RfD]  COMMENT:  BASED ON ROUTE  TO ROUTE EXTRAPOLATION.
        CHRONIC  [RfD] COMMENT:  BASED ON ROUTE TO  ROUTE EXTRAPOLATION. UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
        SUBCHRONIC  [RfC]  COMMENT:  ALSO SEE HEAST  TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC  [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY)
        GENERAL  COMMENT:   ALSO  SEE HEAST TABLE 3:  CARCINOGENICITY.
DICHLOROETHYLENE,  1,1-
LOAEL   9 MG/KG/DAY
                          RAT
        ORAL:  DRINKING     2 YEARS
        WATER
               000075-35-4
                 LIVER
                                 LESIONS
                                                                           9E-3
                                                                           1000
                                                               IRIS
                                                                         005419
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC  [RfD] COMMENT:  UNDER REVIEW,  CURRENT NUMBER SUBJECT TO CHANGE.
        GENERAL  COMMENT:  ALSO  SEE HEAST TABLE 3:  CARCINOGENICITY.
DICHLOROETHYLENE,  1,2-C-
NOAEL   32  MG/KG/DAY      RAT
        ORAL:  GAVAGE       90 DAYS
                  000156-59-2
                                     BLOOD
                                     BLOOD
                                 DECREASED HEMATOCRIT
                                 DECREASED HEMOGLOBIN
                                                                           1E-1
                                                                           300
                                                               1E-2
                                                               3000
                                                                                                          005420
        CHRONIC  [RfD] COMMENT:   UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
IRIS,  EPA'S  INTEGRATED RISK  INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254,  FTS  684-7254.
                                                                                                                     1-26

-------
CHEMICAL  DOSE
LEVEL    ROUTE
HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY)       January 1992


                                                                                               REFERENCE
     SPECIES
EXPERIMENT LENGTH TARGET
                                                   CRITICAL EFFECT
    Subchronic             Chronic
  [RfC]      [RfD]      [RfC]       [RfD]
(mg/cu m) (mg/kg/day)  (mg/cu m)  (mg/kg/day)
   UF         UF       UF        UF
DICHLOROETHYLENE,  1,2-T-
NOAEL    17 MG/KG/DAY
                         HOUSE
        ORAL: DRINKING     90 DAYS
        WATER
            000156-60-5
           BLOOD
                          INCREASED ALKALINE
                          PHOSPHATASE
                                                                  2E-1
                                                                  100
                                                                                           IRIS
DICHLOROPHENOL,  2,3-         000576-24-9
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DICHLOROPHENOL,  2,4-         000120-83-2
NOEL     3    PPM          RAT
        ORAL: DRINKING     2 GENERA-    IMMUNE SYSTEM
        WATER             TIONS
                          ALTERED IMMUNE FUNCTION
                                                                       3E-3
                                                                       100
                                                                                      IRIS
                                                                                                    005895
                                                                                               005315
                                                                                               005314
        SUBCHRONIC  [RfD] COMMENT:    THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC [RfD] COMMENT:  BASED ON A 2-GENERATION  REPRODUCTION STUDY WITH EXPOSURES BEFORE AND DURING GESTATION, PARTURITION, AND WEANING OF
                             PUPS.
DICHLOROPHENOL,  2,5-         000583-78-8
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DICHLOROPHENOL,  2,6-         000087-65-0
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DICHLOROPHENOL,  3,4-         000095-77-2
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DICHLOROPHENOL,  3,5-         000591-35-5
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DICHLOROPHENOXY  ACETIC  ACID,  2,4-
NOAEL    1       MG/KG/DAY  RAT
        ORAL: DIET         91 DAYS    BLOOD          TOXICITY
                                   LIVER          TOXICITY
                                   KIDNEY         TOXICITY

        SUBCHRONIC  [RfD]  COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
                          000094-75-7
                                                                  1E-2
                                                                  100
                                                                                           IRIS
                                                                                               005316
                                                                                               005317
                                                                                               005318
                                                                                               005319
                                                                                                    010265
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT: (513) 569-7254.  FTS 684-7254.
                                                                                                                                  1-27

-------
CHEMICAL  DOSE
LEVEL     ROUTE
                 HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGEN I CITY)       January 1992


                                                                                                                 REFERENCE
     SPECIES
EXPERIHENT LENGTH TARGET
DICHLOROPHENOXY)BUTYRIC ACID,  4-(2,4-
NOAEL    8       MG/KG/OAY  DOG
        ORAL: DIET         90 DAYS     CARDIOVASCULAR
                                    SYSTEM
                                    WHOLE BODY

        GENERAL COMMENT:  FORMERLY LISTED AS 2.4-DB.

DICHLOROPROPANE,  1,1-        000078-99-9
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                           CRITICAL EFFECT



                                                000094-82-6

                                           HEMORRHAGE

                                           INCREASED MORTALITY
DICHLOROPROPANE,  1,2-
NOAEL    69.3 MG/CU M       RAT
        INHALATION:        13 WEEKS
        INTERMITTENT
                          000078-87-5

                            NASAL MUCOSA     HYPERPLASIA
DICHLOROPROPANE,  1,3-        000142-28-9
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DICHLOROPROPANE,  2,2-        000594-20-7
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DICHLOROPROPENE,  1,3-
NOAEL    5       PPM        MOUSE
        INHALATION:        2 YEARS
        INTERMITTENT
                          000542-75-6

                            NASAL MUCOSA
                            NASAL MUCOSA
                                HYPERTROPHY
                                HYPERPLASIA
    Subchronic  •           Chronic
  [RfC]      [RfDJ      [RfC]       [RfD]
(mg/cu m) (ing/kg/day) (mg/cu m)   (mg/kg/day)
                                                                                   UF
                                                                          UF
                                                                        8E-2
                                                                        100
                       UF
                                                              1.3E-2
                                                              100
                     IRIS
                                                              2E-2
                                                              30
                                                                                  IRIS
        SUBCHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
NOEL
3      MG/KG/DAY  RAT
ORAL: DIET        90 DAYS     ORGANS          INCREASED WEIGHT

GENERAL COMMENT:  ALSO SEE HEAST  TABLE 3: CARCINOGENICITY.
DICHLORPROP                    000120-36-5
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

        CHRONIC [RfD] COMMENT:  UNDER REVIEW.
                                                                        3E-3
                                                                        1000
                                                                                                                  UF
                               IRIS
                                                                                                               IRIS
005890
                                                                                                                 005897
                                         005898
                                                                                                                 005899
                                                                                                                 005900
                                                                                                      010351
                                                                                                                         005901
                                                                                                                 005896
IRIS,  EPA'S INTEGRATED RISK  INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER  INFORMATION: IRIS USER SUPPORT: (513)  569-7254,  FTS 684-7254.
                                                                                                                            1-28

-------
                         HEAST TABLE 1:  SUBCHRONIC  AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)       January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                         SPECIES
                    EXPERIMENT LENGTH TARGET
                                                   CRITICAL EFFECT
                                                 Subchronic             Chronic
                                              [RfC]      [RfO]      [RfC]       [RfD]     REFERENCE
                                             (mg/cu m)  (mg/kg/day)  (mg/cu m)  (tng/kg/day)
                                                UF         UF       UF         UF
DICYCLOPENTADIENE
NOEL     32 MG/KG/DAY

        ORAL:-DIET
                                  000077-73-6
                         RAT
                         3 GENERA-
                         TIONS
                                                   NONE OBSERVED
                                                        3E-1
                                                        100
                                                             3E-2
                                                             1000
                              005425
        SUBCHRONIC [RfD] COMMENT:    BASED  ON A 3-GENERATION REPRODUCTION STUDY.
        CHRONIC [RfD] COMMENT:   BASED ON A  3-GENERATION REPRODUCTION STUDY.
        SUBCHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC [RfC] COMMENT:   ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
DIELDRIN
NOAEL    0.005 MG/KG/DAY

        ORAL: DIET
                         RAT
                         2 YEARS
                                  000060-57-1
LIVER
LESIONS
5E-5
100
                                                                                                                IRIS      005429
        SUBCHRONIC [RfD] COMMENT:    THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DIETHYL PHTHALATE
NOAEL    750 MG/KG/DAY

        ORAL: DIET
                                  000084-66-2

                         RAT
                         16 WEEKS    WHOLE BODY
                                    ORGANS
                                                   DECREASED GROWTH
                                                   DECREASED WEIGHT

                                                000311-45-5
                                                        8E+0
                                                        100
                                                             IRIS       005620
DIETHYL-P-NITROPHENYL  PHOSPHATE
         (PARAOXON)
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DIETHYLANILINE, N,N-         000091-66-7
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DIETHYLENE  GLYCOL  MONOBUTYL  ETHER          000112-34-5
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                          005922
                                                                                                                          005903
                                                                                                                          005482
IRIS,  EPA'S INTEGRATED RISK INFORMATION  SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS  USER SUPPORT: (513)  569-7254,  FTS 684-7254.
                                                                                                                                     1-29

-------
                         HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                                              January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
                         SPECIES
                   EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
                                                            SiAchronic             Chronic
                                                          [RfC]      [RfO]       [RfC]      [RfD]     REFERENCE
                                                        (na/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                                                    UF
                                                                                               UF
                                                                                                        UF
                                                                                                                   UF
DIETHYLENE GLYCOL  MONOETHYL  ETHER
NOEL     200 MG/KG/DAY      RAT
        ORAL: DRINKING                KIDNEY
        WATER
        CHRONIC [RfD] COMMENT:  BASED ON A 3-GENERATION REPRODUCTION STUDY.
                                                    000111-90-0

                                                   HISTOPATHOLOGY
NOEL
        500  MG/KG/DAY
        ORAL: DIET
RAT
90 DAYS
DIETHYLFORMAMIDE
NOEL     0.546 MG//DAY, 5 DAYS/WEEK
                         RAT
        ORAL: GAVAGE       73 WEEKS
  KIDNEY
  TEST IS

000617-84-5
                                                    IMPAIRED FUNCTION
                                                    INCREASED WEIGHT
                                                    NONE OBSERVED
DIETHYLHYDRAZINE,  1,2-      001615-80-1
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DIMETHOATE
NOEL     0.05 MG/KG/DAY

        ORAL: DIET
                         RAT
                         2 YEARS
                                  000060-51-5
           BRAIN
                 DECREASED CHOLINESTERASE
                 ACTIVITY
        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

                                  000131-11-3
DIMETHYL  PHTHALATE
NOEL     1000 MG/KG/DAY

        ORAL: DIET
                         RAT
                         2 YEARS
                                    KIDNEY
                          EFFECTS
5E+0
100
                                                                                            1.1E-2
                                                                                            100
2E-4
300
                                                                    1E+1
                                                                    100
                                                                                        2E+0
                                                                                        100
                                                                                        1.1E-2
                                                                                        100
                                                                                                                 IRIS
                                                                                                       IRIS
                                                                              1E-H
                                                                              100
        CHRONIC [RfD] COMMENT:   UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
        CHRONIC [RfC] COMMENT:   THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE  (10/1/90)  BY THE RfD/RfC WORKGROUP.
DIMETHYLANILINE,  N,N-        000121-69-7
LOAEL    22.32 MG/KG/DAY
                         MOUSE
        ORAL: GAVAGE       13 WEEKS    SPLEEN
                                                   EFFECTS
                                                                                            2E-2
                                                                                            1000
                                                                                        IRIS
                                                                                        005478
                                                                                        005476
                                                                                        010437
                                                                                                                          005921
                                                                                                                          005923
                                                                                                                          010267
                                                                                                 005924
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION: IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                     1-30

-------
                         HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN  CARCINOGENICITY)
                                                                                                                            January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
                         SPECIES
                   EXPERIHENT LENGTH TARGET
                                                   CRITICAL EFFECT
                                 Subchronic            Chronic
                              [RfC]      [RfD]      [RfC]       [RfD]    REFERENCE
                             (mg/cu m)  (mg/kg/day) (mg/cu m)  (ing/kg/day)
                                UF         UF       UF        UF
DIMETHYLFORMAMIDE,  N,N-
NOAEL    96 MG/KG/DAY
                         RAT
                         119 DAYS
        ORAL: DIET
                                  000068-12-2
                                    LIVER
EFFECTS
                                                                                           1E+0
                                                                                           100
                                                            1E-1
                                                            1000
LOAEL
                                                                                 3E-2
                                                                                 300
        SUBCHRONIC  [RfC] COMMENT:  THE CHRONIC INHALATION  [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION  [RfC].
22 MG/CU M HUMAN
INHALATION:
INTERMITTENT
LIVER
GASTROINTES-
TINAL SYSTEM
EFFECTS
EFFECTS
                                                                                                     IRIS
DIMETHYLPHENOL,  2,3-
                                  000526-75-0
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

                                  000105-67-9
DIMETHYLPHENOL,  2,4-
NOAEL    50   MG/KG/DAY     MOUSE
        ORAL: GAVAGE       90 DAYS
                                   NERVOUS SYSTEM
                                   BLOOD
EFFECTS
ALTERATIONS
                                        2E-1
                                        300
DIMETHYLPHENOL,  2,5-         000095-87-4
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DIMETHYLPHENOL,  2,6-
NOEL     0.6  MG/KG/DAY     RAT
        ORAL              8 MONTHS
DIMETHYLPHENOL,  3,4-
NOEL     1.4  MG/KG/DAY     RAT
        ORAL              8 MONTHS
DIMETHYLTEREPHTHALATE
LOAEL    125 MG/KG/DAY
                         RAT
        ORAL: DIET         103 WEEKS
                                  000576-26-1

                                   WHOLE BODY
                                   ORGANS,  MAJOR

                                  000095-65-8

                                   WHOLE BODY
                                   ORGANS,  MAJOR
                                   CARDIOVASCULAR
                                   SYSTEM

                                  000120-61-6
INCREASED WEIGHT
LESIONS
DECREASED WEIGHT
LESIONS
ALTERED BLOOD PRESSURE
6E-3
100
                                        1E-2
                                        100
                                   KIDNEY
                                                   INFLAMMATION
                                                                                           1E-1
                                                                                           1000
                                                                                                               IRIS
                                                            IRIS
                    IRIS
                                                                                                               IRIS
                              005925


                              010352
                                                                                                                        005926
                                                                                                                        010266
                                                                                                                        005928
                                                                      005431
                              005437
                                                                                                                        005930
        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].


IRIS,  EPA'S INTEGRATED RISK  INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                   1-31

-------
                        HEAST  TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)       January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
    Subchronic             Chronic
  [RfC]     [RfO]      [RfC]       [RfO]    REFERENCE
(mg/cu m) (na/lcg/day) (na/cu m)  (ma/kg/day)
   UF         UF       UF        UF
DIMETHYLUREA, N,N-           000598-94-7
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DI-N-OCTYL  PHTHALATE
LOAEL    175  MG/KG/DAY     RAT
        ORAL: DIET         7-12
                         MONTHS
              000117-84-0

                KIDNEY
                LIVER
                LIVER
                LIVER
INCREASED WEIGHT
INCREASED WEIGHT
INCREASED SCOT ACTIVITY
INCREASED SGPT ACTIVITY
       CHRONIC [RfD] COMMENT:  UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.

DINITRO-0-CRESOL, 4,6-      000534-52-1
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DINITRO-P-CRESOL, 2,6-      000609-93-8
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DINITROBENZENE,  1,2-         000528-29-0
         (o-DINITROBENZENE)         000528-29-0
NOAEL    0.4     MG/KG/DAY RAT
        ORAL: DRINKING    16 WEEKS    SPLEEN
        WATER
                               INCREASED WEIGHT
        SUBCHRONIC  [RfD]  COMMENT:   DERIVED BY ANALOGY  TO 1,3-DINITROBENZENE.
        CHRONIC [RfD] COMMENT:  DERIVED BY ANALOGY TO  1,3-DINITROBENZENE.
DINITROBENZENE,  1,3-
         (m-DINITROBENZENE)
NOAEL    0.4     MG/KG/DAY  RAT
        ORAL: DRINKING
        WATER
              000099-65-0
                SPLEEN
                               INCREASED WEIGHT
           2E-2
           1000
2E-2
1000
                                        4E-3
                                        100
                               4E-4
                               1000
                                                                                                    005931
                                                                     010275
                                                                                                    008883


                                                                                                    005934




                                                                                                    010201
                                                                       1E-3
                                                                       100
                                                           IRIS
                                         008884
IRIS,  ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                               1-32

-------
                         HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                         January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
                                                   CRITICAL EFFECT
    Subchconic             Chronic
  [RfC]      [RfO]      [RfC]       [RfD]     REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu a) (mg/kq/day)
                                                                                   UF
                                                                          UF
                       UF
            UF
DINITROBENZENE,  1,4-         000100-25-4
         (p-DINITROBENZENE)
NOAEL    0.4     MG/KG/OAY  RAT
        ORAL: DRINKING     16 WEEKS    SPLEEN
        WATER
                                INCREASED WEIGHT
           4E-3
           100
          4E-4
          1000
        SUBCHRONIC [RfD] COMMENT:  DERIVED BY ANALOGY TO 1,3-DINITROBENZENE.
        CHRONIC [RfD] COMMENT:  DERIVED BY ANALOGY TO 1,3-DINITROBENZENE.

DINITROPHENOL,  2,3-          000066-56-8
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINITROPHENOL,  2,4-
LOAEL    2       MG/KG/DAY  HUMAN
        ORAL
               000051-28-5

                EYE
                                                   CATARACT
           2E-3
           1000
IRIS
IRIS
        SUBCHRONIC [RfD] COMMENT:  THE  CHRONIC [RfD] WAS ADOPTED AS THE SUBCHRONIC [RfD].
        CHRONIC [RfD] COMMENT:  BASED ON A THERAPEUTIC DOSE.
        CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (10/1/91) BY THE  RfD/RfC WORKGROUP.

DINITROPHENOL,  2,5-          000329-71-5
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DINITROPHENOL,  2,6-          000573-56-8
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DINITROPHENOL,  3,5-          000586-11-8
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DINITROTOLUENE,  2,3-         000602-01-7
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINITROTOLUENE,  2,4-
              000121-14-2
                                                                                                     IRIS
        CHRONIC [RfD] COMMENT:  UNDER REVIEW.
        CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (3/1/91) BY THE RfD/RfC WORKGROUP.
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
                                                                                                     010202
                                                                                                     005936
010438
                                                                                                     005937
                                                                                                     005938
                                                                                                     005939
                                                                                                     005940
                                                                                                     005941
IRIS,  EPA'S INTEGRATED RISK  INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER  INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                1-33

-------
                         HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)      January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
                CRITICAL EFFECT
                                  Sifcchronic             Chronic
                               [RfC]      [RfD]      [RfC]       [RfO]     REFERENCE
                             (mg/cu m) (mg/kg/day) (ma/cu m)  (mg/kg/day)
                                 UF         UF        UF         UF
DINITROTOLUENE,  2,5-         000619-15-8
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

DINITROTOLUENE,  2,6-         000606-20-2
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

        CHRONIC [RfD]  COMMENT:  UNDER REVIEW.
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

DINITROTOLUENE,  3,4-         000610-39-9
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINOSEB
LOAEL    1  MG/KG/DAY      RAT
        ORAL: DIET        29 WEEKS
               000088-85-7
                                    FETUS
                                                    DECREASED WEIGHT
                                                                         1E-3
                                                                         1000
        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
        CHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL  [RfD]  WAS DETERMINED FROM A 3-GENERATION REPRODUCTION STUDY.
DIPHENYLAMINE,N,N-
NOEL    2.5 MG/KG/DAY

       .ORAL: DIET
     DOG
     2 YEARS
               000122-39-4
WHOLE  BODY
LIVER
KIDNEY
DECREASED WEIGHT  GAIN
INCREASED WEIGHT
INCREASED WEIGHT
2.5E-2
100
        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD],

DIRECT LIGHTFAST  BLUE        004399-55-7
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
DISULFOTON
LOAEL    0.04 MG/KG/DAY

        ORAL: DIET
                    000298-04-4
      RAT
      2 YEARS
                                    EYE
                                    BLOOD
                DEGENERATION
                CHOLINESTERASE INHIBITION
                                                         4E-5
                                                         1000
        SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
                                                                             IRIS
                                                                                             IRIS
                                                                                             IRIS
                                                                                                       005942
                                                                                                       005943
                                                                                                       005944
                                                                       005945
                                                                                                       005946
                                                                                                       005947
                                                                                                       010412
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT: (513) 569-7254,  FTS 684-7254.
                                                                                                                  1-34

-------
                          HEAST TABLE  1: SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)      January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                          SPECIES
                    EXPERIMENT LENGTH TARGET
                                                     CRITICAL EFFECT
     Subchronic             Chronic
  [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
    UF         UF       UF         UF
ENDOSULFAN
LOAEL   0.15 MG/KG/DAY

        ORAL: DIET
                                   000115-29-7
                          RAT
                          2 GENERA-   KIDNEY
                          TIONS
                                                     LESIONS
            5E-5
            3000
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC  ORAL  [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].
        CHRONIC  [RfD] COMMENT:   BASED ON A 2-GENERATION REPRODUCTION STUDY.
ENDOTHALL
NOEL    2 MG/KG/DAY

        ORAL:  DIET
                                   000145-73-3
                          DOG
                          2 YEARS
                                     STOMACH          INCREASED WEIGHT
                                     SMALL INTESTINE  INCREASED WEIGHT
            2E-2
            100
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC  ORAL  [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].

                                   000072-20-8
ENDRIN
NOEL    0.025  MG/KG/DAY

        ORAL:  DIET
                          DOG
                          2 YEARS
                                     CENTRAL          CONVULSIONS
                                     NERVOUS  SYSTEM
                                     LIVER           LESIONS
            3E-4
            100
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC  ORAL  [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].
IRIS
          010439
IRIS
005948
IRIS
005445
IRIS,  EPA'S  INTEGRATED RISK  INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT: (513)  569-7254, FTS 684-7254.
                                                                                                                                         1-35

-------
                          HEAST  TABLE  1: SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN CARCINOGENICITY)       January 1992

                                                                                         Subchronic             Chronic
CHEMICAL  DOSE             SPECIES                                                      [RfC]      [RfD]       [RfC]       IRfO]     REFERENCE
LEVEL     ROUTE      EXPERIMENT LENGTH TARGET          CRITICAL EFFECT                (mg/cu m) (mg/kg/day)  (ro/cu •)  Caa/kg/day)
                                                                                        UF         UF       UF         UF


EPICHLOROHYDRIN                000106-89-8
NOEL    0.25   MG/CU M     MOUSE                                                       3E-3                                     005950
        INHALATION:        87-88 DAYS  NASAL TURBINATE  INJURY                           100
        INTERMITTENT

NOAEL   0.5    PPM         RAT                                                                              1E-3                905950
        INHALATION:        90 DAYS     NASAL EPITHELIUM LESIONS                                               300
        INTERMITTENT

        CHRONIC  [RfC] COMMENT:  UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.

LOAEL   37.8  MG/CU M
                          RAT                                                                   2E-3                 IRIS       010440
        INHALATION:        136 WEEKS   KIDNEY          LESIONS                                    1000
        INTERMITTENT

        SUBCHRONIC [RfD] COMMENT:  BASED ON ROUTE-TO-ROUTE EXTRAPOLATION.  THE CHRONIC ORAL [RfD] WAS ADOPTED AS  THE  SUBCHRONIC ORAL  [RfD].
        CHRONIC  [RfD] COMMENT:  BASED ON ROUTE-TO-ROUTE EXTRAPOLATION.
        GENERAL  COMMENT:  ALSO SEE  HEAST TABLE 3: CARCINOGENICITY.

EPIC                               000759-94-4
NOEL    2.5 MG/KG/DAY
                          RAT                                                                   2.5E-2             '  IRIS       005959
        ORAL: DIET         2 GENERA-   HEART           DEGENERATIVE CARDIOMYOPATHY                 100
                          TIONS

        SUBCHRONIC [RfD] COMMENT:    THE CHRONIC  ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC  ORAL [RfD].
        CHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS DETERMINED FROM A 2-GENERATION  REPRODUCTION STUDY.

ETHOPROP                          013194-48-4
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT                                                                          005951
IRIS,  ERA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.         1-36

-------
                         HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                                     January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
                 SPECIES
            EXPERIMENT LENGTH TARGET
                                                   CRITICAL EFFECT
                                                            Subchronic            Chronic
                                                         [RfC]      [RfD]      [RfC]      [RfD]     REFERENCE
                                                       (mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
ETHOXYETHANOL,  2-
NOAEL    380 MG/CU M

        INHALATION:
        INTERMITTENT
                           000110-80-5
LOAEL
NOEL
357 MG/KG/DAY

ORAL:  GAVAGE

50 UL/KG/DAY
ORAL:  GAVAGE
                 RABBIT
                 13 WEEKS
RAT
103  WEEKS

RAT
21 DAYS
                            BLOOD
                                    WHOLE BODY
                                    FETUS
                          ALTERED  HEMATOLOGY
DECREASED WEIGHT
SKELETAL MALFORMATIONS
                                                                                    UF
                               2E+0
                               30
                                                                                              UF
                                                                                                UF
                                                                                              IRIS
                                                                                         UF
                    4E-1
                    1000
5E-1
100
010441




005470


00546S
        SUBCHRONIC [RfD] COMMENT:  BASED  ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS 1-21 OF GESTATION.

ETHOXYETHANOL  ACETATE,  2-   000111-15-9

        CHRONIC [RfC] COMMENT:  UNDER REVIEW.
        SUBCHRONIC [RfD] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
        CHRONIC [RfD] COMMENT:  ALSO SEE  HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ETHOXYETHYL ACRYLATE,  2-          000106-74-1
        DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT

ETHOXYETHANOL  DODECANOATE,  2-           000106-13-8
        DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT

ETHOXYETHANOL  PHOSPHATED,  2-            068554-00-7
        DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT

ETHOXYETHYL METHACRYLATE,  2-            002370-63-0
        DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
ETHYL  ACETATE
NOEL    900  MG/KG/DAY     RAT
        ORAL: GAVAGE       90 DAYS
                           000141-78-6

                            WHOLE BODY
                            WHOLE BODY
                          INCREASED MORTALITY
                          DECREASED WEIGHT
                                         9E+0
                                         100
                                                                                       IRIS
                                                                                                                  005953
                                                                                                                  005956
                                                                                                                  005955
                                                                                                                  005954
                              005957
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                            1-37

-------
                          HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN CARCINOGENICITY)       January 1992

                                                                                       Subchronic             Chronic
CHEMICAL  DOSE             SPECIES                                                     [RfC]      [RfD]      [RfC]       [RfO]     REFERENCE
LEVEL     ROUTE      EXPERIMENT LENGTH TARGET           CRITICAL EFFECT                (mg/cu m) (mg/kg/dav) (mg/cu ro)  (ma/kg/day)
                                                                                      UF         UF        UF         UF


ETHYLBENZENE                    000100-41-4
NOAEL   434 HG/CU M                                                                   1E+0                 IRIS                005446
                                                                                     300
                          RABBIT
        INHALATION:        24 DAYS     FETUS            DEVELOPMENTAL  TOXICITY
        INTERMITTENT

                          RAT
        INHALATION:        19 DAYS     FETUS            DEVELOPMENTAL  TOXICITY
        INTERMITTENT

        SUBCHRONIC [RfC]  COMMENT:  THE CHRONIC  INHALATION  [RfC] WAS ADOPTED AS THE SUBCHRONIC  INHALATION  [RfC].
        CHRONIC [RfC] COMMENT:  BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURE DURING GESTATIONAL DAYS 1-19 (RAT) OR 1-24 (RABBIT).

NOEL    97.1 MG/KG/DAY
                          RAT                                                                   1E+0                 IRIS      005447
        ORAL: GAVAGE       182 DAYS    LIVER            HEPATOTOXICITY                             100
                                     KIDNEY           NEPHROTOXICITY

ETHYL  CHLORIDE                 000075-00-3
NOAEL   1504 PPM           MOUSE                                                       1E+1                 IRIS                010371
        INHALATION:        10 DAYS     FETUS            DELAYED OSSIFICATION              300
        INTERMITTENT

        SUBCHRONIC [RfC]  COMMENT:  THE CHRONIC  INHALATION  [RfC] WAS ADOPTED AS THE SUBCHRONIC  INHALATION  [RfC].
        CHRONIC [RfD] COMMENT:  BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS  6-15 OF GESTATION.

ETHYL  DIPROPYLTHIOCARBAMATE,2-  (See  EPTC)

ETHYL  ETHER                     000060-29-7
NOAEL   500    MG/KG/DAY  RAT                                                                   2E+0                 IRIS      010396
        ORAL: GAVAGE       13 WEEKS    WHOLE BODY       DECREASED WEIGHT                            300

ETHYL  METHACRYLATE            000097-63-2
NOEL    7.5 MG/KG/DAY     RAT                                                                   9E-2                 9E-2      005961
        ORAL: DRINKING     2 YEARS     KIDNEY           INCREASED RELATIVE WEIGHT                   100                  100
        WATER

        CHRONIC [RfD] COMMENT:  CALCULATED FROM METHYL METHACRYLATE DATA  BY MULTIPLYING BY THE RATIO OF THE MOLECULAR
                              WEIGHTS (114.5/100.13). UNDER REVIEW,  CURRENT NUMBER SUBJECT TO CHANGE.



IRIS, EPA'S INTEGRATED  RISK INFORMATION  SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT:  (513)  569-7254, FTS 684-7254.         1-38

-------
                         HEAST  TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCIN06ENICITY)      January 1992

                                                                                     Subchronic             Chronic
CHEMICAL  DOSE            SPECIES                                                    [RfC]      [RfO]       [RfC]      [RfD]     REFERENCE
LEVEL    ROUTE      EXPERIMENT LENGTH TARGET          CRITICAL EFFECT                (mg/cu m) (mg/kg/day) (ng/cu m)  (na/kg/day)
                                                                                     UF         UF       UF         UF


ETHYL-0-XYLENE  ,4-            000934-80-5
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT                                                                      008882

ETHYLANILINE,  N-               000103-69-5
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT                                                                      005958

ETHYLENE CYANOHYDRIN          000109-78-4
NOEL     30   MG/KG/DAY     RAT                                                                 3E-1                 3E-1      005780
        ORAL: DRINKING     90 DAYS     HEART            DECREASED WEIGHT                           100                  100
        WATER                        BRAIN            DECREASED WEIGHT

ETHYLENE DIAMINE               000107-15-3
NOAEL   22.6  •  MG/KG/DAY  RAT                                                                 2E-1       IRIS       2E-2      005796
        ORAL: DIET        3 MONTHS   HEART            DECREASED WEIGHT                           100                  1000
                                    BLOOD            HEMATOLOGIC CHANGES

        CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE  (5/1/91) BY THE RfD/RfC WORKGROUP.
        SUBCHRONIC [RfC] COMMENT:   ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)

ETHYLENE GLYCOL                000107-21-1
                                                                                                                 IRIS      00545A
NOEL     200     MG/KG/DAY  RAT                                                                 2E+0                          005452
        ORAL: DIET                   FETUS            FETOTOXICITY                              100

        SUBCHRONIC [RfD] COMMENT:   BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS  6-15 OF GESTATION.

ETHYLENE GLYCOL MONOBUTYL ETHER          000111-76-2
NOAEL   121     MG/CU M    RAT                                                       2E-1                 2E-2                010353
        INHALATION:       13 WEEKS   BLOOD            ALTERED HEMATOLOGY               100                  1000
        INTERMITTENT

        CHRONIC [RfC] COMMENT:  UNDER REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER  SUPPORT:  (513) 569-7254, FTS 684-7254.        1-39

-------
                         HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)       January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
    Sifcchronic             Chronic
  [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
(mg/cu m) (mg/lcg/day) (mg/cu m)  (mg/lcg/day)
                                                                                   UF
                                                                           UF
                                                    UF
                                  UF
ETHYLENE THIOUREA
LOAEL    0.25 MG/KG/DAY

        ORAL: DIET
               000096-45-7
     RAT
     24 MONTHS
                                    THYROID
                                                   HYPERPLASIA
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST  TABLE 3:  CARCINOGENICITY.

ETHYLTOLUENE,  M-              000620-14-4
        DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT

ETHYLTOLUENE,  0-              000611-14-3
        DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT

ETHYLTOLUENE,  P-              000622-96-8
        DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
FLUORANTHENE
NOAEL    125     MG/KG/DAY  MOUSE
        ORAL: GAVAGE       90 DAYS
FLUORENE
NOAEL    125     MG/KG/DAY  MOUSE
        ORAL: GAVAGE       13 WEEKS
               000206-44-0

                KIDNEY
                LIVER
                BLOOD

               000086-73-7

                ERYTHROCYTES
NEPHROPATHY
INCREASED WEIGHT
HEHATOLOGICAL  CHANGES
DECREASED COUNTS
                                         8E-5
                                         3000
                                         4E-1
                                         300
                                         4E-1
                                         300
                                IRIS
                                IRIS
                                IRIS
010397
                                                                                                      005963
                                                                                                      005962
                                                                                                      005964
010168
010169
FLUORIDE
NOAEL    0.06 MG/KG/DAY

        ORAL: DRINKING
        WATER
      HUMAN
               007782-41-4
                TOOTH
                                FLUOROSIS
                                         6E-2
                                         1
                                                                                            IRIS
                                                                                                      005965
IRIS,  EPA'S INTEGRATED RISK  INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                 1-40

-------
CHEMICAL  DOSE
LEVEL      ROUTE
FLURIDONE
NOEL     200 PPM
        ORAL: DIET
                         HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)      January 1992


                                                                                                                            REFERENCE
     SPECIES
EXPERIMENT LENGTH TARGET
                          RAT
                          2  YEARS
               059756-60-4

                 KIDNEY
                 TEST IS
                 WHOLE BODY
                 ORGANS
                                                     CRITICAL EFFECT
                                                     GLOMERUIONEPHRITIS
                                                     ATROPHY
                                                     DECREASED WEIGHT
                                                     DECREASED WEIGHT
                                  Subchronic             Chronic
                               [RfC]      [RfD]      [RfC]        [RfD]
                             (mg/cu m) (qg/kg/day) (na/cu m)  (ing/kg/day)
                                                                                      UF
        SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED  AS THE SUBCHRONIC ORAL [RfD],

                                   000133-07-3
FOLPET
NOEL     10     MG/KG/DAY  DOG
        ORAL: CAPSULE      1  YEAR
                                     WHOLE BODY
                                     BLOOD
                                                     ALTERED WEIGHT  GAIN
                                                     ALTERED CHEMISTRY
        SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL {RfD] WAS ADOPTED  AS THE SUBCHRONIC ORAL [RfD],
        GENERAL COMMENT:   ALSO SEE HEAST  TABLE 3: CARCINOGENICITY.
FORMALDEHYDE
NOAEL    15      MG/KG/DAY  RAT
        ORAL: DRINKING     2  YEARS
        WATER
                                   000050-00-0

                                                     LESIONS

                                                     DECREASED WEIGHT GAIN

        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
                 GASTROINTES-
                 TINAL SYSTEM
                 WHOLE BODY
FORMALDEHYDE  CYANOHYDRIN           000107-16-4
        DATA  INADEQUATE FOR  QUANTITATIVE RISK ASSESSMENT
FORMIC ACID                     000064-18-6
NOAEL    200    MG/KG/OAY  RAT
        ORAL: WATER        MULT I-      WHOLE BODY
                          GENERATION
                                                     DECREASED GROWTH
                                                                                                 UF
                                         8E-2
                                         100
                                                                                                          UF
                                                                                              1E-1
                                                                                              100
                                                                          2E-1
                                                                          100
                                                                                              2E+0
                                                                                              100
                                                                                                                     UF
                                                                                                                   IRIS
                                                                                                                             005966
                                                                                               IRIS
                                                                        005967
                                                              IRIS
                                                                        010398
                                                                                               2E+0
                                                                                               100
                                                                                                                             005782
                                                                                                                             010268
        CHRONIC  [RfD] COMMENT:  BASED ON A  MULT I-GENERATION  STUDY. WITHDRAWN FROM IRIS (12/1/90).  UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.

                                   000110-00-9

                                                                                                                   IRIS       005462
FURAN
NOAEL   1.4 MG/KG/DAY
        ORAL:  GAVAGE
                          MOUSE
                          13 WEEKS
                 LIVER
LESIONS
                                                                          1E-2
                                                                          100
IRIS,  EPA'S  INTEGRATED RISK  INFORMATION  SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS  USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                        1-41

-------
                         HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)      January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
                                                     CRITICAL EFFECT
                                                    Subchronic             Chronic
                                                 [RfC]       [RfD]      [RfC]       [RfDJ     REFERENCE
                                                (mg/cu m) (mg/kg/day) (mg/cu m)   (mg/kg/day)
                                                   UF          UF        UF         UF
FURFURAL
LOAEL    7.9  MG/KG/DAY

        ORAL: GAVAGE
               000098-01-1
      RAT
      13 WEEKS
                                     LIVER
                                                     HEPATOTOXICITY
                                                            3E-2
                                                            300
                               IRIS
                                         005466
        SUBCHRONIC [RfC]  COMMENT:  ALSO SEE  HEAST TABLE 2:  ALTERNATE METHODS  - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)
        CHRONIC  [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
GLYCIDALDEHYDE
NOAEL    10 PPM
        INHALATION:
        'INTERMITTENT
      RAT
      12 WEEKS
000765-34-4

 WHOLE BODY
 BLOOD
 KIDNEY
                                 DECREASED WEIGHT GAIN
                                 HEMATOPOIETIC EFFECTS
                                 EFFECTS
1E-2
300
4E-3
300
        SUBCHRONIC [RfD]  COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION  FACTOR OF 0.5.
        CHRONIC  [RfD] COMMENT:  BASED ON ROUTE  TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
        GENERAL  COMMENT:   ALSO SEE HEAST TABLE  3: CARCINOGENICITY.
HEPTACHLOR
NOEL    0.15  MG/KG/DAY     RAT
        ORAL: DIET         2 YEARS
               000076-44-8
                 LIVER
                  INCREASED WEIGHT
                                                                           5E-4
                                                                           300
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL  [RfD]  WAS  ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
HEPTACHLOR  EPOXIDE
LOAEL   0.0125  MG/KG/DAY   DOG
        ORAL: DIET         60 WEEKS
               001024-57-3

                 LIVER
                  INCREASED RELATIVE WEIGHT
          1.3E-5
           1000
        SUBCHRONIC  [RfD] COMMENT:    THE CHRONIC ORAL [RfD]  WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
1E-3
3000
                                                                                                IRIS
005968
                                                                                IRIS
                                         005506
                                                                               IRIS
                              010399
HEPTANE,  N-                     000142-82-5
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
HEXABROMOBENZENE
NOAEL   2      MG/KG/DAY  RAT
        ORAL:  DIET         12 WEEKS
               000087-82-1

                 LIVER
                                                     INDUCED  CARBOXYLESTERASE
                                                     ACTIVITY
                                                            2E-2
                                                            100
                               IRIS
                                                                                                          005969
                                         005970
IRIS,  EPA'S  INTEGRATED RISK  INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                     1-42

-------
                         HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY)
                                                                                                                               January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                         SPECIES
                    EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
     Subchronic             Chronic
  [RfC]      [RfO]      [RfC]       [RfD]     REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu ro)  (mg/kg/day)
   UF        UF        UF         UF
HEXACHLOROBENZENE             000118-74-1
NOAEL    0.08    MG/KG/DAY  RAT
        ORAL: DIET        130 WEEKS  LIVER
                                                    EFFECTS
                                                                                             8E-4
                                                                                             100
                                                   IRIS
                                                             IRIS
                                          005510
        SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL  [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC [RfD]  COMMENT:  THE CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (3/1/91) BY THE RfD/RfC WORKGROUP.
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGEN!CITY.
HEXACHLOROBUTADIENE
NOAEL    0.2     MG/KG/DAY  RAT
        ORAL: DIET        2 YEAR
                                   000087-68-3

                                    KIDNEY
                                                    TOXICITY
                                         2E-3
                                         100
        SUBCHRONIC [RfD] COMMENT:     THE CHRONIC  ORAL [RfD]  WAS ADOPTED  AS THE SUBCHRONIC ORAL [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

HEXACHLOROCYCLOHEXANE,  DELTA- AND  EPSILON-
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT

        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

                                           000058-89-9
HEXACHLOROCYCLOHEXANE,  GAMMA-
NOAEL    0.33    MG/KG/DAY  RAT
        ORAL: DIET        12 WEEKS   LIVER
                                    KIDNEY
                                                    TOXICITY
                                                    TOXICITY
                                                                                             3E-3
                                                                                             100
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.

HEXACHLOROCYCLOPENTADIENE   000077-47-4
NOAEL    0.15    PPM       RAT
        INHALATION:       13 WEEKS    RESPIRATORY     LESIONS
        INTERMITTENT                  TRACT


                                     FORESTOMACH     LESIONS

                                   000067-72-1

                                     KIDNEY          EFFECTS
                                                                                   7E-4
                                                                                    100
NOAEL    7.1     MG/KG/DAY  RAT
        ORAL: GAVAGE      13 WEEKS

HEXACHLOROETHANE
NOAEL    1    MG/KG/DAY     RAT
        ORAL: DIET        16 WEEKS
                                         7E-2
                                         100
                                         1E-2
                                         100
                                IRIS
0055H
                                                             IRIS
                                                                                                                           002222
                                                                       005537
                                                   7E-5
                                                   1000
                                                                                                                 IRIS
                                IRIS
                                          010445
                                                                                                                           005299
005518
        CHRONIC  [RfC] COMMENT:  THE CHRONIC INHALATION  [RfC]  IS CONSIDERED NOT VERIFIABLE, IRIS INPUT PENDING.
        GENERAL  COMMENT:   ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
IRIS,  EPA'S  INTEGRATED  RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS  USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                      1-43

-------
                         HEAST  TABLE  1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)       January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
                 SPECIES
            EXPERIMENT LENGTH TARGET
                                            CRITICAL EFFECT
                                  Subchronic             Chronic
                               [RfC]      [RfO]       [RfC]      [RfO]     REFERENCE
                              (mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                                                     UF
                                                                                                UF
                                                                                                 UF
                                                                                                            UF
HEXACHLOROPHENE
LOAEL    0.75   MG/KG/DAY   DOG
        ORAL: DIET        13 WEEKS
                           000070-30-4
                             NERVOUS SYSTEM   EFFECTS
                                                                                     3E-3
                                                                                     300
                                                                                                          IRIS
HEXAMETHYLENE  DIAMINE        000124-09-4
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
HEXANE,  N-
LOAEL    570  MG/KG/DAY
        ORAL: GAVAGE
LOAEL
73    MG/CU M
INHALATION:
INTERMITTENT
                 RAT
                 90 DAYS
                         HUMAN
                           000110-54-3

                             NERVOUS SYSTEM
                             TESTIS
                             WHOLE BODY
NEUROPATHY
ATROPHY
DECREASED WEIGHT GAIN
                                         6E-1
                                         1000
6E-2
10000
                                    NERVOUS SYSTEM   NEUROTOXICITY
                                                                           2E-1
                                                                           300
                                                                                                       IRIS
        SUBCHRONIC [RfC] COMMENT:   THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].

HEXANONE,  2-                    000591-78-6
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
HYDROGEN  SULFIDE
NOAEL    42      MG/CU M
        INHALATION:
        INTERMITTENT
                  MOUSE
                  13 WEEKS
NOAEL    3.1     MG/KG/DAY  PIG
        ORAL: DIET        105 DAYS
                           007783-06-4
                             NASAL MUCOSA
                             GASTROINTES-
                             TINAL SYSTEM
                                            INFLAMMATION
                                            DISTURBANCE
                                                                           9E-3
                                                                           100
                                                                                                IRIS
                                                                                     3E-2
                                                                                     100
                                                                                                                  IRIS
HYDROQUINONE
NOAEL    4.29    MG/KG/DAY  HUMAN
        ORAL: DIET        3-5 MONTHS  BLOOD
                                                                                                IRIS
                           000123-31-9

                                            HEMATOLOGICAL EFFECTS

CHRONIC  [RfC] COMMENT:  THE CHRONIC INHALATION  [RfC]  IS CONSIDERED  NOT VERIFIABLE (10/1/90)  BY THE RfD/RfC WORKGROUP.
                                         4E-1
                                         10
4E-2
100
IRON                              007439-89-6
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
                                                                                                                    005972
                                                                                                                    005973
005974
                                                                        010273
                                                                                                                    005976
                                                                                                                    010354
                                                                                                                           010269
                                                                                                                    005526
                                                                                                                    005527
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                      1-44

-------
                         HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN  CARCINOGENICITY)
                                                                                                                                January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                         SPECIES
                    EXPERIMENT LENGTH TARGET
                                                     CRITICAL EFFECT
                                                    Subchronic             Chronic
                                                 [RfC]      [RfD]      [RfC]        [RfD]     REFERENCE
                                               (mg/cu m)  (mgAg/day) (mg/cu m)  (mg/kg/day)
                                                   UF         UF       UF         UF
ISOBUTYL  ALCOHOL
NOEL    316   MG/KG/DAY     RAT
        ORAL: DIET         13 WEEKS
ISOPHORONE
NOEL    150   MG/KG/DAY     DOG
        ORAL: CAPSULE      90 DAYS
                                   000078-83-1

                                     NERVOUS SYSTEM
                                     NERVOUS SYSTEM

                                   000078-59-1

                                     KIDNEY
                                                     HYPOACTIVITY
                                                     ATAXIA
                                                     LESIONS
                                                           3E+0
                                                           100
                                                           2E+0
                                                           100
          IRIS
                    IRIS
IRIS
        CHRONIC  [RfC] COMMENT:  THE CHRONIC  INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (3/1/91)  BY THE RfD/RfC  WORKGROUP.
        GENERAL  COMMENT:   ALSO SEE HEAST TABLE 3: CARCINOGEN I CITY.
ISOPROPALIN
NOEL    15   MG/KG/DAY
        ORAL: DIET
LACTONITRILE
                         RAT
                         90 DAYS
033820-53-0

  BLOOD
  ORGANS,
  UNSPECIFIED

000078-97-7
                                                     HEMATOLOGICAL EFFECTS

                                                     ALTERED WEIGHTS
1.5E-1
100
                                                                                                                   IRIS
        DATA  INADEQUATE FOR  QUANTITATIVE RISK ASSESSMENT

LEAD                              007439-92-1
        CHRONIC  [RfC] COMMENT:  REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
        CHRONIC  [RfD] COMMENT:  REFER TO IRIS.
        GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGEN I CITY.

LEAD  ALKYLSCDIMETHYLETHYL LEAD, METHYLTRIETHYL LEAD, TETRABUTYL LEAD, TETRAETHYL LEAD, TETRAHETHYL LEAD,
                TETRAPROPYL  LEAD, TRIETHYL LEAD, TRIMETHYL   LEAD, TRIMETHYLETHYL LEAD,  AND TRIPROPYL  LEAD)

        CHRONIC  [RfC] COMMENT:  REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
        CHRONIC  [RfD] COMMENT:  REFER TO IRIS.

LINDANE  (See HEXACHLOROCYCLOHEXANE,  GAMMA)

                                   000330-55-2
LINURON
LOAEL    0.625 MG/KG/DAY   DOG
        ORAL: DIET        2 YEARS
                                     BLOOD
                                                     ABNORMAL PIGMENTATION
                                                                                               2E-3
                                                                                               300
                                                                                IRIS
        SUBCHRONIC  [RfD]  COMMENT:  THE CHRONIC ORAL [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
        GENERAL  COMMENT:   ALSO  SEE HEAST TABLE 3: CARCINOGENICITY.
                              005977
                               005910
                                                                                                                             005978
                                                                                                                             005783
                                                                                                                             910447
                                                                                                                             010447
                                                                                                                             910448
                                                                                                                             010448
                               005990
IRIS, EPA'S  INTEGRATED RISK  INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                                        1-45

-------
                         HEAST  TABLE  1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN  CARCINOGENICITY)
                                                                                                                       January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
                 SPECIES
            EXPERIMENT LENGTH TARGET
                           CRITICAL EFFECT
    Sifcchronic             Chronic
  [RfC]      [RfDJ      [RfC]       [RfD]     REFERENCE
(mg/cu m) (mg/kg/dav) (mg/cu m)  (mg/kg/day)
                                                                                     UF
                                                                                        UF
                                                                                UF
                                   UF
MALATHION                        000121-75-5
NOEL    0.23    MG/KG/DAY  HUMAN
        ORAL: CAPSULE     47 DAYS    ERYTHROCYTES     DECREASED CHOLINESTERASE
                                                    ACTIVITY

        SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL  [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC [RfC] COMMENT:  UNDER REVIEW.
MALEIC  ANHYDRIDE
NOAEL    10    MG/KG/DAY
       ORAL: DIET
                           000108-31-6

                             KIDNEY          LESIONS

SUBCHRONIC [RfD]  COMMENT:  THE  CHRONIC ORAL  [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].

                           000123-33-1

                             KIDNEY          ALTERED  FUNCTION

SUBCHRONIC [RfD]  COMMENT:  THE  CHRONIC ORAL  [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].

                           000109-77-3
MALEIC  HYDRAZIDE
LOAEL   500  MG/KG/DAY
       ORAL: DIET
RAT
2 YEARS
RAT
2 YEARS
MALONONITRILE
LOAEL    0.21   MG/KG/DAY   RAT
        ORAL: GAVAGE      120 DAYS
MANCOZEB
NOEL     2.9  MG/KG/DAY     RAT
        ORAL: DIET        90 WEEKS

MANEB
NOEL     5    MG/KG/DAY     MONKEY
        ORAL: DIET        6 MONTHS
                             LIVER
                             SPLEEN

                           008018-01-7

                             THYROID

                           012427-38-2

                             THYROID
                           EFFECTS
                           EFFECTS
                           GOITROGENIC EFFECTS
                                            INCREASED WEIGHT
                                                                                      2E-2
                                                                                      10
            1E-1
            100
            5E-1
            1000
                                                                                      2E-4
                                                                                      1000
                                                                    3E-2
                                                                    100
                                                                    5E-2
                                                                    100
                                                                                         IRIS
IRIS
                                                                                         IRIS
                                                                                        2E-5
                                                                                        10000
                                3E-2
                                100
                                IRIS
                                          005991
005992
                                                                                                  005993
                                          005994
          005995
          005996
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                               1-46

-------
                          HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER  THAN CARCIN06ENICITY)
                                                                                                                                  January 1992
CHEMICAL   DOSE
LEVEL     ROUTE
                          SPECIES
                    EXPERIMENT LENGTH TARGET
                                                     CRITICAL EFFECT
                                   Subchronic             Chronic
                                [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
                              (mg/cu m)  (mg/kg/day) (na/cu m)  (mg/kg/day)
                                                                                       UF
                                                                                                   UF
                                                                                                            UF
                                                                                                                       UF
MANGANESE
LOAEL    0.97    MG/CU M   HUMAN
        INHALATION:
        INTERMITTENT
                                    007439-96-5

                                     LUNG
                                     CENTRAL
                                     NERVOUS SYSTEM
RESPIRATORY EFFECTS
PSYCHOMOTOR DISTURBANCES
4E-4
900
                                                     IRIS
                                                                         010355
                          HUMAN
                                     CENTRAL         EFFECTS
                                     NERVOUS SYSTEM
NOAEL    0.14 MG/KG/DAY

        ORAL: DIET

        SUBCHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC  ORAL  [RfD]

                                    000950-10-7
MEPHOSFOLAN
NOEL    0.09 MG/KG/DAY     RAT
        ORAL: DIET         17 WEEKS
MERCURY,  INORGANIC
NOAEL   0.009   MG/CU M    HUMAN
        INHALATION:
        INTERMITTENT
                                     LIVER
                                     KIDNEY
                                     BLOOD

                                     ERYTHROCYTES

                                     BRAIN
DECREASED WEIGHT
DECREASED WEIGHT
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
                                    007439-97-6

                                     NERVOUS SYSTEM    NEUROTOXICITY
                                3E-4
                                30
                                          1E-1
                                          1
                                                                                                9E-4
                                                                                                100
                     3E-4
                     30
                                                                                                                     IRIS
                                                               9E-5
                                                               1000
                                                                                                                               010356
                                         005997
010270
        SUBCHRONIC  [RfC] COMMENT:   THIS VALUE IS SPECIFICALLY FOR ELEMENTAL MERCURY.
        CHRONIC [RfC] COMMENT:  THIS  VALUE IS SPECIFICALLY FOR ELEMENTAL  MERCURY. UNDER  REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
                          RAT
        ORAL,
        PARENTERAL
                                     KIDNEY
                                                      EFFECTS
        CHRONIC [RfD] COMMENT:  UNDER  REVIEW, CURRENT  NUMBER SUBJECT TO CHANGE.

MERPHOS                           000150-50-5
NOEL    0.1     MG/KG/DAY  HEN
        ORAL:  CAPSULE      3 MONTHS    NERVOUS SYSTEM    ATAXIA
                                      NERVOUS SYSTEM    DELAYED NEUROTOXICITY
                                      WHOLE BODY       DECREASED WEIGHT
                                          3E-4
                                          1000
                                                                                                3E-4
                                                                                                300
                               3E-4
                               1000
                                                               IRIS
                                                                                                                               005800
                                                                         005998
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                          1-47

-------
CHEMICAL  DOSE
LEVEL     ROUTE
                          HEAST  TABLE  1: SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)      January 1992
     SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
     Siixhronic             Chronic
  [RfC]      [RfD]      [RfC]        [RfD]
(mg/cu m) (TO/kg/day) (mg/cu m)  (mg/kg/day)
    UF         UF       UF          UF
                                                                         REFERENCE
MERPHOS  OXIDE
NOEL    0.1    MG/KG/DAY   HEN
        ORAL:  CAPSULE      3 MONTHS
METHACRYLONITRILE
NOAEL   3.2 PPM            DOG
        INHALATION:        90 DAYS
        INTERMITTENT
               000078-48-8

                 NERVOUS  SYSTEM
                 NERVOUS  SYSTEM
                 WHOLE  BODY

               000126-98-7

                 LIVER
                 LIVER
                                                     ATAXIA
                                                     DELAYED NEUROTOXICITY
                                                     DECREASED WEIGHT
INCREASED SCOT
INCREASED SGPT
                                          3E-4
                                          300
            1E-3
            300
                                 IRIS
005999
                                                               IRIS
005812
        SUBCHRONIC  [RfD] COMMENT:  BASED ON ROUTE  TO ROUTE EXTRAPOLATION.
        CHRONIC  [RfD] COMMENT:   BASED ON ROUTE TO  ROUTE EXTRAPOLATION.
        SUBCHRONIC  [RfC] COMMENT:  ALSO SEE HEAST  TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY)
        CHRONIC  [RfC] COMMENT:   ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHANOL
NOEL    500     MG/KG/DAY  RAT
        ORAL:  GAVAGE       90 DAYS
               000067-56-1

                 BLOOD

                 BLOOD
                 BRAIN
                                                     INCREASED ALKALINE
                                                     PHOSPHATASE
                                                     INCREASED SGPT
                                                     DECREASED WEIGHT
                                          5E+0
                                          100
                                 IRIS
                                           010271
METHOMYL
NOEL    2.5   MG/KG/DAY     DOG
        ORAL:  DIET         24 MONTHS
               016752-77-5

                 KIDNEY
                 SPLEEN
LESIONS
LESIONS
            2.5E-2
            100
                                                               IRIS
                                                                         005802
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
METHOXYCHLOR                    000072-43-5
NOEL    5.01     MG/KG/DAY  RABBIT
        ORAL:  GAVAGE       13 DAYS     REPRODUCTION
                                                     LOSS OF LITTERS
                                                                           5E-3
                                                                           1000
                                                               IRIS
                                           010357
        SUBCHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC  [RfD] COMMENT:   BASED ON A TERATOLOGY STUDY WITH EXPOSURES DURING DAYS 7-19 OF GESTATION.
        CHRONIC  [RfC] COMMENT:   THE CHRONIC [RfC]  WAS CONSIDERED NOT VERIFIABLE,  IRIS INPUT PENDING.
IRIS,  EPA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                     1-48

-------
                         HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)      January 1992

                                                                                    Sifcchronic             Chronic
CHEMICAL  DOSE            SPECIES                                                   [RfC]      [RfO]      [RfCl       [RfO]     REFERENCE
LEVEL    ROUTE     EXPERIMENT LENGTH TARGET          CRITICAL EFFECT                (na/cu m) (ing/kg/day)  (tng/cu m)  (mg/kq/day)
                                                                                   UF         UF       UF         UF


METHOXYETHANOL,  2-           000109-86-4
NOAEL  93      HG/CU M    RABBIT                                                    2E-1      4E-2      IRIS      4E-3      010372
        INHALATION:        13 WEEKS    TESTIS          LESIONS                         100       100                 1000
        INTERMITTENT

       SUBCHRONIC [RfO] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
       CHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. UNDER REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.

METHOXYETHANOL  ACETATE,  2-  000110-49-6

       GENERAL COMMENT:  SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

METHYL  ACETATE                 000079-20-9
NOEL     1156 MG/KG/DAY     RAT                                                                1E+1                1E+0      010002
       ORAL: GAVAGE       90 DAYS     LIVER           INCREASED ALKALINE                        100                 1000
                                                   PHOSPHATASE
                                    LIVER           INCREASED SGPT
                                    LIVER           INCREASED WEIGHT

       CHRONIC [RfD] COMMENT:  UNDER REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE. CALCULATED FROM DATA OBTAINED  WITH METHANOL BY
                             MULTIPLYING BY THE MOLECULAR  WEIGHT RATIO (74.08/32.04)

METHYL  ACRYLATE               000096-33-3

       GENERAL COMMENT:  SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)

METHYL  BROMIDE  (See BROMOMETHANE)

METHYL  CHLORIDE (See  CHLOROMETHANE)

METHYL  CHLOROCARBONATE      000079-22-1
                                                                                                                         010006
       GENERAL COMMENT:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513)569-7300; FTS 684-7300.
       CHRONIC [RfD] COMMENT:  WITHDRAWN FROM IRIS  (5/1/89)
METHYL ETHYL  BENZENES  (See ETHYL  TOLUENE,  m-,  o-  or p-)
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT: (513) 569-7254,  FTS 684-7254.         1-49

-------
                          HEAST TABLE  1: SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)       January 1992
CHEMICAL DOSE
LEVEL     ROUTE
                          SPECIES
                    EXPERIMENT  LENGTH TARGET
                                                     CRITICAL EFFECT
                                                   Subchronic             Chronic
                                                [RfC]      [RfD]       [RfC]       [RfO]     REFERENCE
                                              (mg/cu m)  (mg/kg/day) (cng/cu m)  (mg/kg/day)
                                                                                       UF
                                                                                                  UF
                                                                                                            UF
                                                                                                                       UF
METHYL ETHYL KETONE
NOAEL   693     MG/CU M    RAT
        INHALATION:        12 WEEKS
        INTERMITTENT
                                   000078-93-3
                                                       NONE OBSERVED
                                                          5E-1
                                                          100
                     5E-2
                     1000
                                                                                                                              005558
        CHRONIC  [RfD] COMMENT:  WITHDRAWN FROM IRIS  (8/1/91). UNDER REVIEW, CURRENT NUMBER SUBJECT  TO CHANGE.
        SUBCHRONIC  [RfC] COMMENT:  ALSO SEE HEAST  TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC  [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE  METHODS - SUBCHRONIC AND CHRONIC  TOXICITY (OTHER  THAN CARCINOGENICITY)
METHYL ISOBUTYL  KETONE
NOEL    50    MG/KG/DAY     RAT
        ORAL:  GAVAGE       13 WEEKS
                                   000108-10-1

                                     LIVER
                                     KIDNEY
                                                     EFFECTS
                                                     EFFECTS
                                                          5E-1
                                                          100
                     5E-2
                     1000
005563
        CHRONIC  [RfD] COMMENT:  WITHDRAWN FROM IRIS (3/1/91).  UNDER REVIEW, CURRENT NUMBER SUBJECT  TO CHANGE.
        SUBCHRONIC tRfC]  COMMENT:  ALSO SEE HEAST  TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC  [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE  METHODS - SUBCHRONIC AND CHRONIC  TOXICITY (OTHER  THAN CARCINOGENICITY)
METHYL ISOCYANATE
                                   000624-83-9
                                                                                                          IRIS
        CHRONIC  [RfC] COMMENT:   THE CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (3/1/91) BYT THE RfD/RfC  WORKGROUP.

                                   022967-92-6

                                                     EFFECTS
METHYL MERCURY
LOAEL   0.003 MG HG/KG/DAY  HUMAN
        ORAL
CENTRAL
NERVOUS  SYSTEM
3E-4
10
                                                                               IRIS
        SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
        CHRONIC  [RfD] COMMENT:   THE ADMINISTERED  DOSE WAS CALCULATED FROM 200 NG HG/ML OF BLOOD.
METHYL METHACRYLATE          000080-62-6
NOEL    7.5  MG/KG/OAY     RAT
        ORAL:  DRINKING     24 MONTHS   KIDNEY
        WATER
                                                     INCREASED  RELATIVE WEIGHT
                                                                                               8E-2
                                                                                               100
                                                                               8E-2
                                                                               100
        CHRONIC  [RfD] COMMENT:   UNDER REVIEW,  CURRENT NUMBER SUBJECT TO CHANGE.
                                                                                                                              010013
                                                                                         005547
                               0100H
IRIS,  EPA'S  INTEGRATED RISK  INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER  INFORMATION: IRIS  USER SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                                          1-50

-------
                         HEAST  TABLE 1:  SUBCHRONIC  AND  CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY)
                                                                                                                      January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
                 SPECIES
            EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
                                                            Subchronic             Chronic
                                                         [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
                                                        (mg/cu m)  (mg/kg/day)  (mg/cu m)   (mg/kg/day)
                                                           UF         UF       UF         UF
METHYL  PARATHION
NOEL   0.25   MG/KG/DAY   RAT
       ORAL: DIET        2 YEARS
                           000298-00-0

                            BLOOD
                            BLOOD
                            ERYTHROCYTES
                            BLOOD
                          DECREASED  HEMOGLOBIN
                          DECREASED  HEMATOCRIT
                          DECREASED  COUNT
                          DECREASED  CHOLINESTERASE
                          ACTIVITY
                                         2.5E-4
                                         100
                                                                                       IRIS
                                                                                                 010015
        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].

METHYL STYRENE, ALPHA-        000098-83-9

        GENERAL COMMENT:  SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
METHYL  STYRENE (MIXED ISOMERS)
                                         025013-15-4
        GENERAL COMMENT:  SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
        CHRONIC [RfD] COMMENT:  UNDER REVIEW.  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
        CARCINOGENICITY)
METHYL-4-CHLOROPHENOXYACETIC  ACID,2-
         (MCPA)
                                               000094-74-6
NOEL
0.15  MG/KG/DAY
ORAL:  DIET
DOG
52 WEEKS
                                    KIDNEY
                                    LIVER
EFFECTS
EFFECTS
                                         5E-4
                                         300
                                                                                                                IRIS
                                                                                                                          010007
        SUBCHRONIC [RfD] COMMENT:
                           THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
METHYL-4-CHLOROPHENOXY)BUTYRIC ACID,4-
         (MCPB)
NOEL     12  MG/KG/DAY      DOG
        ORAL: DIET        13 WEEKS    REPRODUCTIVE
                                    SYSTEM
                                                 000094-81-5
NOEL
12  MG/KG/DAY
ORAL:  DIET
RAT
13 WEEKS
                                    LIVER
                                    KIDNEY
                                            TOXICITY
EFFECTS
EFFECTS
                                                                                     1E-1
                                                                                     100
                                                                                       IRIS
                                                                                                 010008
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254,  FTS 684-7254.
                                                                                                                             1-51

-------
                        HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)       January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                 SPECIES
            EXPERIMENT LENGTH TARGET
               CRITICAL EFFECT
                                 Subchronic             Chronic
                               [RfC]      [RfD]       [RfC]       [RfD]     REFERENCE
                             (mg/cu m) (mq/kg/day) (mg/cu m)  (mg/kg/day)
                                UF         UF       UF         UF
METHYL-4-CHLOROPHENOXY)PROPIONIC ACID,2-(2-
         (MCPP)
NOEL    3    MG/KG/DAY     RAT
                         90 DAYS     KIDNEY
                                                         000093-65-2
ORAL: DIET
METHYLCYCLOHEXANE
NOAEL   287 MG/CU M
       INHALATION:
       INTERMITTENT
                           000108-87-2
                 RAT

                 1 YEAR
KIDNEY
KIDNEY
                INCREASED RELATIVE
                WEIGHT
MINERALIZATION
PAPILLARY HYPERPLASIA
                                         1E-2
                                         300
                                              3E+0
                                              100
METHYLENE-BIS(2-CHLOROANILINE),  4,4'-
LOAEL    7.3     MG/KG/DAY  DOG
        ORAL: CAPSULE      9  YEARS     LIVER
                                    BLADDER
                                                 000101-14-4
                                            EFFECTS
                                            INFLAMMATION
                                                                                    7E-4
                                                                                    10000
                                                  3E+0
                                                  100
                                                                                                        IRIS
                                                                            7E-4
                                                                            10000
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.

METHYLENE  BROMIDE             000074-95-3
         (DIBROMOMETHANE)

        CHRONIC [RfC] COMMENT:  UNDER REVIEW.
        GENERAL COMMENT:  SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHYLENE  CHLORIDE
NOAEL    694.8   MG/CU M    RAT
        INHALATION:        2 YEARS
        INTERMITTENT
                           000075-09-2

                            LIVER           TOXICITY
                                              3E+0
                                              100
                                                   3E+0
                                                   100
        CHRONIC [RfC] COMMENT:  UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
        GENERAL COMMENT:  ALSO SEE HEAST  TABLE 3:  CARCINOGENICITY.
NOAEL    5.85    MG/KG/DAY  RAT
        ORAL: DRINKING     24 MONTHS   LIVER
        WATER
                                            TOXICITY
                                                                                    6E-2
                                                                                    100
                                                                            IRIS
        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS  ADOPTED AS  THE SUBCHRONIC ORAL  [RfD].
                                                                                      010009
                                                                                                                  010431
                                                                      010413
005552
                                                                       005553
IRIS,  EPA'S INTEGRATED RISK  INFORMATION SYSTEM,  IS UPDATED  MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                             1-52

-------
                         HEAST TABLE  1:  SUBCHRONIC  AND  CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                                                January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                         SPECIES
                    EXPERIMENT LENGTH TARGET
                                                    CRITICAL  EFFECT
                                                   Subchronic             Chronic
                                                 [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
                                               (mg/cu m) (mg/kg/dav) (mg/cu m)  (mg/kg/day)
                                                  UF         UF        UF         UF
METHYLENEDIPHENYL  ISOCYANATE,  4,4'-
NOAEL    0.2     MG/CU M   RAT
        INHALATION:       24 MONTHS   NASAL CAVITY
        INTERMITTENT
                                                        000101-68-8

                                                    LESIONS
                                                 2E-5
                                                 300
        CHRONIC [RfC]  COMMENT:  UNDER  REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.

                                   002385-85-5
MIREX
LOAEL    0.015  MG/KG/DAY

        ORAL: DIET
                         VOLE,
                         PRAIRIE
                         MULTI-     OFFSPRING
                         GENERATION
                  INCREASED MORTALITY
        SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
MOLINATE
NOEL    0.2  MG/KG/DAY
        ORAL: GAVAGE
                         RAT
002212-67-1

  REPRODUCTIVE
  SYSTEM
                                                    TOXICITY
        SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD],
        CHRONIC  [RfD]  COMMENT:  BASED ON A REPRODUCTION STUDY.
MOLYBDENUM
LOAEL    0.14    MG/KG/DAY  HUMAN
        ORAL: WATER,  DIET
                                   007439-98-7
                                    URINE
                                    JOINTS
                                    BLOOD
                  INCREASED URIC ACID
                  PAIN, SWELLING
                  DECREASED COPPER LEVELS
        CHRONIC  [RfD]  COMMENT:  UNDER  REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
        SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC [RfD] WAS ADOPTED AS THE SUBCHRONIC [RfD].
MONOCHLOROBUTANE  (See CHLOROBUTANE,!-)
                                                           2E-6
                                                           10000
2E-3
100
                                                                                              5E-3
                                                                                              30
          2E-5
          300
010449
                                                                                                                  IRIS
                                                                                                                            005569
                                                                                                                  IRIS
                                                                                                                            010017
                                                                               5E-3
                                                                                 30
                              910414
IRIS,  ERA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER  SUPPORT: (513) 569-7254,  FTS 684-7254.
                                                                                                                                       1-53

-------
CHEHICAL  DOSE
LEVEL     ROUTE
                  HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)      January 1992


                                                                                                                    REFERENCE
     SPECIES
EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
    Subchronic             Chronic
  [RfC]      [RfD]      [RfC]       [RfO]
(mg/cu 01) (mg/kg/day) (mg/cu m)  (mg/kg/day)
    UF         UF        UF         UF
NAPHTHALENE
NOEL    50     MG/KG/DAY  RAT
        ORAL: GAVAGE      13 WEEKS
                           000091-20-3

                             WHOLE BODY      DECREASED WEIGHT

CHRONIC  [RfD] COMMENT:  UNDER REVIEW, CURRENT NUMBER SUBJECT  TO CHANGE.
                                                                          4E-2
                                                                          1000
                                4E-2
                                1000
NAPHTHOQUINONE,   1,4-        000130-15-4
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
NICKEL
NOAEL    100   PPM         RAT
        ORAL: DIET        2 YEARS
                           007440-02-0

                             WHOLE BODY
                             ORGANS, MAJOR
                                                    DECREASED WEIGHT
                                                    DECREASED WEIGHT
                                                                          2E-2
                                                                          300
                                IRIS
        SUBCHRONIC [RfD]  COMMENT:    THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].
        CHRONIC [RfC]  COMMENT:  UNDER REVIEW.

        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY  (UNDER NICKEL REFINERY DUST AND NICKEL  SUBSULFIDE).

NICOTINONITRILE                000100-54-9
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

NITRIC OXIDE                    010102-43-9
        REFER TO APPENDIX A:  TECHNICAL  INFORMATION, SECTION V ON  NATIONAL AMBIENT AIR QUALITY STANDARDS.
NITRITE
NOEL    10   PPM
        ORAL: DRINKING
        WATER
                  HUMAN
               014797-65-0

                 BLOOD           METHEMOGLOBINEMIA
            1E-1
            10
                                                                                                           IRIS
010446
                                                                                                                     010020
                                          005579
                                                                                                                     005584
                                                                                                                     905584
010021
        SUBCHRONIC [RfD]  COMMENT:  THIS  VALUE IS BASED ON NITRATE  (NITROGEN) DATA FROM THE MOST SENSITIVE  HUMAN POPULATION (INFANTS).
                                 THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
        CHRONIC  [RfD]  COMMENT:  THIS VALUE  IS BASED  ON NITRATE (NITROGEN) DATA  FROM THE MOST  SENSITIVE HUMAN POPULATION  (INFANTS).

NITROANILINE,  M-              000099-09-2
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT                                                                        010400
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT: (513)  569-7254,  FTS 684-7254.
                                                                                                                                1-54

-------
CHEMICAL  DOSE
LEVEL     ROUTE
                          HEAST TABLE  1: SUB CHRONIC  AND  CHRONIC TOXICITY  (OTHER  THAN CARCIN06ENICITY)      January 1992
     SPECIES
EXPERIMENT LENGTH TARGET
                                                     CRITICAL EFFECT
                                                   Subchronic             Chronic
                                                [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
                                              (na/cu m) (mg/kq/day) (mg/cu m)   (mg/kg/day)
                                                 UF         UF        UF         UF
NITROANILINE, 0-
LOAEL   9.8 MG/CU M
        INHALATION:
        INTERMITTENT
      RAT
      4 WEEKS
               000088-74-4
BLOOD
                                                                                                         010022
                                 HEMATOLOGICAL EFFECTS
2E-3
1000
6E-4
1000
2E-4
10000
6E-5
10000
        SUBCHRONIC  CRfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
        CHRONIC  [RfD] COMMENT:  BASED ON ROUTE  TO ROUTE EXTRAPOLATION.

NITROANILINE,  P-              000100-01-6
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
NITROBENZENE
LOAEL   25 MG/CU M
               000098-95-3
INHALATION:
INTERMITTENT



INHALATION:
INTERMITTENT



MOUSE
90 DAYS



RAT
90 DAYS




BLOOD
ADRENAL
KIDNEY
LIVER

BLOOD
ADRENAL
KIDNEY
LIVER
                                                                                               5E-3
                                                                                               1000
                                                                                               IRIS
                                                                                                         010024
                                                                                         005589
                                                     HEMATOLOGICAL EFFECTS
                                                     LESIONS
                                                     LESIONS
                                                     LESIONS
                                                     HEMATOLOGICAL EFFECTS
                                                     LESIONS
                                                     LESIONS
                                                     LESIONS

        SUBCHRONIC  [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
        CHRONIC  [RfD] COMMENT:   THE ORAL [RfD], WHILE STILL AVAILABLE ON IRIS,  IS BEING RECONSIDERED BY THE  [RfD] WORKGROUP. BASED ON ROUTE
                               TO ROUTE EXTRAPOLATION.
        SUBCHRONIC  [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC  [RfC] COMMENT:   UNDER REVIEW.  ALSO SEE HEAST  TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
        CARCINOGENICITY)
NITROFURANTOIN
NOAEL   300     PPM        MOUSE
        ORAL:  DIET         13 WEEKS
               000067-20-9
                                     TESTIS
                                                     DEGENERATION
                                                                           7E-1
                                                                           100
                                                                              7E-2
                                                                              1000
                                         005593
IRIS,  EPA'S  INTEGRATED RISK  INFORMATION SYSTEM, IS UPDATED  MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                    1-55

-------
                         HEAST TABLE  1:  SUBCHRONIC  AND  CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)       January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
                 CRITICAL EFFECT
    Sifcchronic             Chronic
  [RfC]      [RfO]      [RfC]       [RfD]     REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
   UF        UF        UF         UF
NITROGEN  DIOXIDE
NOEL    10 PPM
        ORAL: DRINKING
        WATER
      HUMAN
010102-44-0

  BLOOD           METHEMOGLOBINEMIA
            1E+0
            1
                                                                                               IRIS
010402
        SUBCHRONIC [RfD]  COMMENT:  THIS VALUE IS BASED ON NITRATE  (NITROGEN) DATA FROM THE MOST SENSITIVE  HUMAN POPULATION (INFANTS).
                                 THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
        CHRONIC  [RfD]  COMMENT:  THIS VALUE  IS BASED ON NITRATE (NITROGEN) DATA FROM THE MOST  SENSITIVE HUMAN POPULATION  (INFANTS).
        CHRONIC  [RfC]  COMMENT:  REFER TO APPENDIX A:  TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT  AIR QUALITY  STANDARDS.

NITROGEN  OXIDES
        CHRONIC  [RfC]  COMMENT:  REFER TO APPENDIX A:  TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT  AIR QUALITY  STANDARDS.      910402

NITROMETHANE                   000075-52-5
        DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT                                                                        010026

NITROPHENOLS
        DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
NITROPROPANE,  2-
LOAEL    78    MG/CU M
        INHALATION:
        INTERMITTENT
               000079-46-9
      RAT
      22 MONTHS
                 LIVER
                                LESIONS
                                                 2E-2
                                                 1000
                      IRIS
        SUBCHRONIC [RfC]  COMMENT:  THE CHRONIC INHALATION [RfC]  WAS ADOPTED AS THE SUBCHRONIC  INHALATION  [RfC],

NITROSODIPHENYLAMINE,  P-    000156-10-5
        DATA  INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
NITROTOLUENE,  M-
LOAEL   200  MG/KG/DAY     RAT
        ORAL: GAVAGE      6 MONTHS
               000099-08-1
                                     SPLEEN
                                 LESIONS
                                                                          1E-1
                                                                          1000
                                                                               1E-2
                                                                               10000
        SUBCHRONIC [RfD]  COMMENT:  BASED  ON DATA OBTAINED WITH 0-NITROTOLUENE.
        CHRONIC  [RfD] COMMENT:  BASED ON  DATA OBTAINED WITH 0-NITROTOLUENE.
NITROTOLUENE,  0-
LOAEL   200  MG/KG/DAY     RAT
        ORAL:  GAVAGE       6 MONTHS
               000088-72-2
                 SPLEEN
                 KIDNEY
                 LESIONS
                 LESIONS
                                                                          1E-1
                                                                          1000
                                                                               1E-2
                                                                               10000
                                                                                                        005594
                                          010374
                                                                                                        010027
                                          010029
                                          010028
IRIS,  EPA'S  INTEGRATED  RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                   1-56

-------
                         HEAST  TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY)
                                                                                                           January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT LENGTH  TARGET
                                                    CRITICAL EFFECT
    Subchronic             Chronic
  [RfC]      [RfD]      [RfC]       [RfO]     REFERENCE
(mg/cu m) (ing/kg/day) (mg/cu m)  (mg/kg/day)
   UF        UF       UF        UF
NITROTOLUENE,  P-
LOAEL    200  MG/KG/DAY     RAT
        ORAL: GAVAGE      6 MONTHS
               000099-99-0
                                    SPLEEN
                                                    LESIONS
                                                                         1E-1
                                                                         1000
                                1E-2
                                10000
        SUBCHRONIC [RfD] COMMENT:   BASED ON DATA OBTAINED WITH 0-NITROTOLUENE.
        CHRONIC [RfD]  COMMENT:  BASED ON DATA OBTAINED WITH 0-NITROTOLUENE.
OCTABROMODIPHENYL ETHER
NOAEL    2.5     MG/KG/DAY  RAT
        ORAL: GAVAGE      90 DAYS

OCTAMETHYLPYROPHOSPHORAMIDE
NOAEL    0.02    MG/KG/DAY  HUMAN  '
        ORAL              AT LEAST
                         30 DAYS
               032536-52-0

                 LIVER           ENZYME  INDUCTION

                      000152-16-9
                BLOOD
                                DECREASED CHOLINESTERASE
                                ACTIVITY
            3E-2
            100
                                                                         2E-3
                                                                         10
IRIS
                                2E-3
                                10
        CHRONIC [RfD]  COMMENT:  UNDER REVIEW,  CURRENT NUMBER  SUBJECT TO CHANGE.

OZONE                             010028-15-6
        CHRONIC [RfC]  COMMENT:  REFER TO APPENDIX A: TECHNICAL  INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

PARALDEHYDE                     000123-63-7
        DATA  INADEQUATE  FOR QUANTITATIVE RISK  ASSESSMENT
PARATHION
NOAEL    0.064 MG/KG/DAY    HUMAN
        ORAL: CAPSULE     28 DAYS
               000056-38-2

                ERYTHROCYTES
                                                    DECREASED CHOLINESTERASE
                                                    ACTIVITY
            6E-3
            10
6E-3
10
        CHRONIC  [RfD]  COMMENT:  UNDER REVIEW,  CURRENT NUMBER  SUBJECT TO CHANGE.
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.

PARTICULATE  MATTER
        CHRONIC  [RfC]  COMMENT:  REFER TO APPENDIX A: TECHNICAL  INFORMATION, SECTION V ON NATIONAL AMBIENT  AIR QUALITY STANDARDS.
PEBULATE
NOEL    5   MG/KG/DAY
        ORAL: DIET
               001114-71-2
      RAT
      SUBCHRONIC  BLOOD
                                                    INCREASED CLOTTING TIME
            5E-2
            100
5E-2
100
          010030
          010032
          010031
                                                                                                       910031
                                                                                                       010033
005598
                                                                                                       905598
010036
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT: (513)  569-7254,  FTS 684-7254.
                                                                                                                  1-57

-------
                         HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCIN06ENICITY)       January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                         SPECIES
                   EXPERIMENT LENGTH TARGET
                                                   CRITICAL EFFECT
                                 Sifcchronic             Chronic
                               [RfC]       [RfD]      [RfC]       [RfO]     REFERENCE
                             (mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                                                    UF
                                                                                              UF
                                                                                                       UF
                                                                                                                  UF
PENDIMETHALIN
NOEL     12.5 MG/KG/DAY     DOG
        ORAL: CAPSULE      2 YEARS
                                  040487-42-1
                                    LIVER
                                    LIVER
                                    LIVER
                                                   LESIONS
                                                   INCREASED ALKALINE PHOSPHATASE
                                                   INCREASED WEIGHT
        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].

                                      032534-81-9

                                    LIVER           ALTERED ENZYME ACTIVITIES

                                  000608-93-5
PENTABROMODIPHENYL ETHER
NOAEL    1.8     MG/KG/DAY  RAT
        ORAL: GAVAGE       90 DAYS
PENTACHLOROBENZENE
LOAEL    8.3  MG/KG/DAY     RAT
        ORAL: DIET        100 DAYS
                                    LIVER
                                    KIDNEY
TOXICITY
TOXICITY
PENTACHLOROCYCLOPENTADIENE          025329-35-5
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PENTACHLORONITROBENZENE
NOEL     0.75    MG/KG/DAY  DOG
        ORAL: DIET        2 YEARS
                                       000082-68-8

                                    LIVER           TOXICITY
        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST  TABLE 3:  CARCINOGEN I CITY.
PENTACHLOROPHENOL
NOEL     3       MG/KG/DAY  RAT
        ORAL: GAVAGE       62 DAYS
                                  000087-86-5

                                    FETUS
                                                   FETOTOXICITY
                                                                                            4E-2
                                                                                            300
                                         2E-2
                                         100
                                                                                            8E-3
                                                                                            1000
                                         3E-3
                                         300
                                         3E-2
                                         100
                                                            IRIS
IRIS
                                                            IRIS
IRIS
IRIS
          010037
          010038
          010039
                                                                                                                         005302
          010040
          005600
        SUBCHRONIC [RfD] COMMENT:  BASED ON A TERATOLOGY STUDY WITH EXPOSURE 62 DAYS PRIOR TO MATING AND THROUGHOUT GESTATION AND LACTATION.
        CHRONIC [RfC] COMMENT:  UNDER REVIEW.
        GENERAL COMMENT:  ALSO  SEE HEAST TABLE 3:  CARCINOGEN!CITY.
PENTACHLOROPROPENE,  1,1,2,3,3-          001600-37-9
        DATA INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT
                                                                                                                         010041
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED  MONTHLY.  FURTHER INFORMATION:  IRIS USER  SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                    1-58

-------
CHEMICAL  DOSE
LEVEL     ROUTE
                         HEAST TABLE  1:  SUBCHRONIC  AND  CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)      January 1992


                                                                                                                           REFERENCE
     SPECIES
EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
    Subchronic            Chronic
  [RfC]      [RfD]      [RfC]       [RfD]
(mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
   UF        UF        UF         UF
PENTANE,  N-                     000109-66-0
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

PHENANTHRENE                    000085-01-8
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PHENOL
NOAEL    60      MG/KG/DAY  RAT
        ORAL: GAVAGE
                                   000108-95-2

                                     FETUS
                                DECREASED WEIGHT
            6E-1
            100
                                                                                              IRIS
                                                                                                                            005603
                                                                                                                            005604
005824
        SUBCHRONIC [RfD]  COMMENT:  BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.  THE CHRONIC ORAL [RfD]  WAS
                                 ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
        CHRONIC  [RfD]  COMMENT:  BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
        CHRONIC  [RfC]  COMMENT:  THE CHRONIC INHALATION  [RfC] IS CONSIDERED  NOT VERIFIABLE.
PHENYLENEDIAMINE,  M-
NOEL    6   MG/KG/DAY     RAT
        ORAL: DRINKING     90 DAYS
        WATER
                                   000108-45-2

                                     LIVER
                                     LIVER
                                LESIONS
                                INCREASED RELATIVE WEIGHT
            6E-2
            100
                                                                                              IRIS
PHENYLENEDIAMINE,  0-         000095-54-5
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.

                                   000106-50-3

                                    WHOLE BODY       EFFECTS

                                   000062-38-4

                                    KIDNEY          DAMAGE
PHENYLENEDIAMINE,  P-
NOAEL    18.7 MG/KG/DAY     RAT
        ORAL: DIET         103 WEEKS
PHENYLMERCURIC ACETATE
NOAEL    0.0084  MG/KG/DAY  RAT
        ORAL: DIET        2 YEARS
                                                                         8E-5
                                                                         100
                                                                                              1.9E-1
                                                                                              100
                                IRIS
                                                                                                        010044
                                                                                                                            010042
                                          010043
                                          010277
        SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].  CALCULATED  BY ANALOGY TO MERCURY BY
                                 CORRECTING FOR  DIFFERENCES IN MOLECULAR  WEIGHT.
        CHRONIC  [RfD]  COMMENT:  CALCULATED BY ANALOGY TO MERCURY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
IRIS.  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED  MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                      1-59

-------
                         HEAST  TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)       January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                         SPECIES
                    EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
                                                             Subchrom'c             Chronic
                                                          [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
                                                        (mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                                                     UF
                                   000298-02-2
PHORATE
NOAEL    0.033   MG/KG/DAY  RAT
        ORAL: DIET        13 WEEKS    BLOOD           CHOLINESTERASE INHIBITION
                                                                                                UF
                                                                                             2E-4
                                                                                             200
                                                                                                         UF
                                                                                                                    UF
                                                                                        2E-4
                                                                                        200
        SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL [RfD]  WAS ADOPTED FOR SUBCHRONIC EXPOSURE.
        CHRONIC [RfD]  COMMENT:  UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
PHOSGENE
                                   000075-44-5
                                                                                                       IRIS
        CHRONIC [RfC]  COMMENT:  THE  CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (10/1/90) BY THE  RfD/RfC WORKGROUP.

                                   007803-51-2

                                    WHOLE BODY       DECREASED WEIGHT

        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
PHOSPHINE
NOEL     0.026 MG/KG/DAY
        ORAL: DIET
RAT
2 YEARS
                                         3E-4
                                         100
                              IRIS
NOAEL    1.4     MG/CU M
        INHALATION:
        INTERMITTENT

PHOSPHORUS, WHITE
                         RAT
                         24 WKS
           KIDNEY
                                   007723-4-0
EFFECTS
3E-4
1000
3E-5
10000
                                                                                                                 IRIS
        GENERAL COMMENT:  FORMERLY  LISTED AS PHOSPHORUS (INORGANIC COMPOUNDS).

PHOTOCHEMICAL  OXIDANTS
        DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT

PHTHALIC ACID,  M-              000121-91-5
        DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT

PHTHALIC ACID,  0-              000088-99-3
        DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
                                                                        010403
                                                                                                                           010045
                    010174
                                                                                                  010173
                                                                                                                           010452
                                                                                                                           010172
                                                                                                                           010047
                                                                                                                           010046
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                      1-60

-------
                          HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)       January 1992

                                                                                                                              REFERENCE
                                                                                                                              010048
                                                                                                                              010049
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
PHTHALIC ACID, P- 000100-21-0
NOEL 142 MG/KG/DAY RAT
ORAL: DIET 2 YEARS BLADDER
PHTHALIC ANHYDRIDE 000085-44-9
LOAEL 1562 MG/KG/DAY MOUSE
ORAL: DIET 104 WEEKS LUNG
KIDNEY
CRITICAL EFFECT
HYPERPLASIA
HISTOPATHOLOGY
HISTOPATHOLOGY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE
POLYBROMINATED BIPHENYLS
LOAEL 0.07 MG/KG/DAY RAT
ORAL: GAVAGE 25 WEEKS LIVER
LIVER
INCREASED WEIGHT
LESIONS
[RfC] [RfD) [RfC]
(mg/cu ro) (mg/kg/dav) (mg/cu m)
UF UF UF
1E+0
100
2E+0
1000
SUBCHRONIC ORAL [RfD].
7E-5
1000
[RfD]
(mg/kg/day)
UF
1E+0
100
IRIS

7E-6
10000
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
POTASSIUM CYANIDE 000151-50-8
NOAEL 27 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
5E-2
500
IRIS
                                                                                                                              010050
                                                                                                                              010278
        SUBCHRONIC  [RfD] COMMENT:  CALCULATED  BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC
                                 ORAL [RfD]  WAS ADOPTED AS THE SU8CHRONIC ORAL  [RfD].
        CHRONIC  [RfD] COMMENT:   CALCULATED BY  ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
POTASSIUM SILVER CYANIDE
NOAEL    82.7   MG/KG/DAY  RAT
        ORAL: DIET         2 YEARS
                000506-61-6
                                     WHOLE  BODY
                                     THYROID
                                     NERVE
                           DECREASED WEIGHT
                           EFFECTS
                           MYELIN DEGENERATION
                                                                     2E-1
                                                                     500
                     IRIS
                               010279
        SUBCHRONIC  [RfD] COMMENT:  CALCULATED  BY ANALOGY TO FREE  CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC
                                 ORAL [RfD]  WAS ADOPTED AS THE  SUBCHRONIC ORAL  [RfD].
        CHRONIC  [RfD] COMMENT:   CALCULATED BY  ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
PROFLURALIN
NOEL    3 MG/KG/DAY
        ORAL:  DIET
          026399-36-0
RAT
SUBCHRONIC
                           NONE OBSERVED
6E-3
500
6E-3
500
                                                                                                    010051
IRIS,  EPA'S  INTEGRATED RISK  INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                         1-61

-------
                         HEAST  TABLE  1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGEN 1CITY)       January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
                         SPECIES
                    EXPERINENT LENGTH TARGET
                                            CRITICAL EFFECT
                                  SiAchronic             Chronic
                               [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
                             (mg/cu in)  (mg/kg/day)  (mg/cu ml  (mg/kg/day)
                                                                                     UF
                                                                                                UF
                                                                                                         UF
                                                                                                            UF
PRONAMIDE
NOEL    7.5 MG/KG/DAY
        ORAL: DIET
                         DOG
                         2 YEARS
                           023950-58-5

                                          • NONE OBSERVED

SUBCKRON1C [RfD]  COMMENT:  THE  CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

                           001918-16-7
PROPACHLOR
NOEL    13.3 MG/KG/DAY     RAT
        ORAL: DIET        90 DAYS
PROPAZINE
NOEL     5    MG/KG/DAY     RAT
        ORAL: DIET        2 YEARS
                                    WHOLE BODY
                                    LIVER

                                   000139-40-2

                                    WHOLE BODY
                                            DECREASED WEIGHT GAIN
                                            INCREASED RELATIVE WEIGHT
                                            DECREASED WEIGHT GAIN
        SUBCHRONIC [RfD] COMMENT:   THE CHRONIC ORAL  [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

PROPIONITRILE                  000107-12-0
        DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT

PROPYL ALCOHOL,  N-            000071-23-8
        DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
PROPYLENE  GLYCOL
NOEL    50,000 PPM
        ORAL: DIET
NOEL
        6 %
        ORAL: DIET
                 RAT
                 2 YEARS

                 RAT
                 20 WEEKS
                                   000057-55-6

                                    BLOOD
HEMATOLOGICAL EFFECTS
                                         7.5E-2
                                         100
                                         1.3E-1
                                         100
                                         2E-2
                                         300
                                         3E+1
                                         100
IRIS
                                                                                                                 IRIS
                                                                                                          IRIS
2E+1
100
                                                                                                                 IRIS
                                    KIDNEY          LESIONS

        CHRONIC [RfC]  COMMENT:  THE  CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE (6/1/91) BY THE RfD/RfC WORKGROUP.

                                                   052125-53-8

                                                    DECREASED WEIGHT GAIN
PROPYLENE  GLYCOL  MONOETHYL  ETHER
NOEL    680  MG/KG/DAY     RAT
        ORAL: DRINKING     30 DAYS    WHOLE BODY
        WATER
                                                                                     7E+0
                                                                                     100
                                                   IRIS
7E-1
1000
010280
                                                                                                                    010175
          010052
                                                                                                                           010053
                                                                                                                           005627
                                                                       005631
                                                                                                                           005629
005488
        CHRONIC [RfC]  COMMENT:  THE  CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (6/1/91) BY THE RfD/RfC WORKGROUP.
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                      1-62

-------
                         HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER  THAN CARCINOGENICITY)
January 1992
                                                                                     Subchronic            Chronic
                                                                                                                         REFERENCE
                                                                                                                          010276
                                                                                                                          005486
                                                                                                                          010375
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
PROPYLENE GLYCOL MONOMETHYL ETHER 000107-98-2
NOAEL 1000 PPM RAT,
RABBIT
INHALATION: 13 WEEKS CENTRAL EFFECTS
INTERMITTENT NERVOUS SYSTEM
NOEL 947 MG/KG/DAY RAT
ORAL: GAVAGE 35 DAYS LIVER
KIDNEY
PROPYLENE OXIDE 000075-56-9
LOAEL 71 MG/CU M RAT
INHALATION: 2 YEARS NASAL
INTERMITTENT EPITHELIUM
HISTOPATHOLOGY
HISTOPATHOLOGY
EFFECTS
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
PYRENE 000129-00-0
NOAEL 75 MG/KG/DAY MOUSE
ORAL: GAVAGE 13 WKS KIDNEY
PYRIDINE 000110-86-1
NOAEL 1 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER
RDX (CYCLONITE) 000121-82-4
NOEL 0.3 MG/KG/DAY RAT
ORAL 105 WEEKS PROSTATE
EFFECTS
INCREASED WEIGHT
INFLAMMATION
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
RONNEL 000299-84-3
NOAEL 5 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LIVER
EFFECTS
[RfC] [RfD] [RfC]
(mg/cu m) (ing/kg/day) (mg/cu m)
UF UF UF
2E+1 IRIS
30
7E+0
100
3E-2 IRIS
100
AS THE SUBCHRONIC INHALATION [RfC].
3E-1
300
1E-2
100
3E-3
100
SUBCHRONIC ORAL [RfD] .
5E-2
100
[RfD]
(mg/kg/day)
UF

7E-1
1000


IRIS
IRIS
IRIS

5E-2
100
                                                                                                                          010176
                                                                                                                          010055
                                                                                                                          010056
                                                                                                                          010057
       CHRONIC [RfD] COMMENT:  UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                    1-63

-------
                          HEAST TABLE  1: SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)       January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                          SPECIES
                    EXPERIMENT LENGTH TARGET
                                                     CRITICAL EFFECT
     Subchronic             Chronic
  [RfC]      [RfD]      [RfC]        IRfD]     REFERENCE
(mg/cu m) (ns/kg/day) (rag/cu m)  (ing/kg/day)
    UF         UF       UF          UF
                          HUMAN
SELENIOUS ACID                  007783-00-8
NOAEL    0.046  MG/KG/DAY  HUMAN
        ORAL: DIET                    WHOLE BODY       SELENOSIS,  CLINICAL

        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

                                    007782-49-2

                                     WHOLE BODY       SELENOSIS,  CLINICAL

        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].

                                    000630-10-4

                                                     SELENOSIS

        CHRONIC  [RfD] COMMENT:  WITHDRAWN FROM IRIS  (5/1/91). UNDER REVIEW, NUMBER  SUBJECT TO CHANGE.

                                    007440-22-4

                                     SKIN            ARGYRIA
SELENIUM
NOAEL    0.853     MG/DAY
        ORAL: DIET
SELENOUREA
        0.072 MG/KG/DAY
SILVER
LOAEL   0.014 MG/KG/DAY
        IV
                          HUMAN
                                                                                               5E-3
                                                                                               3
            5E-3
            3
            5E-3
            15
                          HUMAN
                          2-9 YEARS
            5E-3
            3
        SUBCHRONIC  [RfD] COMMENT:   THE CHRONIC ORAL  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC [RfD] COMMENT:  BASED ON A TOTAL IV  DOSE OF 1 GRAM.
SILVER CYANIDE
NOAEL   55.7    MG/KG/DAY  RAT
        ORAL:  DIET         2 YEARS
                                    000506-64-9

                                     WHOLE BODY
                                     THYROID
                                     NERVE
                                                     DECREASED  WEIGHT
                                                     EFFECTS
                                                     MYELIN DEGENERATION
                                                                                                1E-1
                                                                                                500
                                                                                                                    IRIS
                                           010415
IRIS
010404
5E-3
15
                                                                                                                    IRIS
008880
                                                                                                                              010453
                                 IRIS
          010283
        SUBCHRONIC  [RfD] COMMENT:   CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES  IN MOLECULAR  WEIGHT. THE CHRONIC ORAL
                                  [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
        CHRONIC [RfD] COMMENT:  CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING  FOR DIFFERENCES IN  MOLECULAR WEIGHT.
IRIS, EPA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                          1-64

-------
                          HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)       January 1992
CHEMICAL DOSE
LEVEL     ROUTE
                  SPECIES
            EXPERIMENT  LENGTH TARGET
                                                     CRITICAL EFFECT
                                                                               Subchronic             Chronic
                                                                             [RfC]      [RfO]      [RfC]       [RfO]     REFERENCE
                                                                           (na/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                                              UF         UF        UF         UF
SIMAZINE
NOEL    0.52  MG/KG/DAY   RAT
        ORAL: DIET         2 YEARS
                           000122-34-9

                             WHOLE BODY
                             BLOOD
                                                     DECREASED WEIGHT GAIN
                                                     HEMATOLOGICAL EFFECTS
                                                                                       2E-3
                                                                                       300
                     2E-3
                     300
          010177
        CHRONIC  [RfO] COMMENT:  WITHDRAWN FROM  IRIS (9/1/91). UNDER REVIEW,  CURRENT NUMBER SUBJECT TO CHANGE.
        GENERAL  COMMENT:  ALSO  SEE HEAST TABLE  3: CARCINOGENICITY.
SODIUM CYANIDE
NOAEL    20.4  MG/KG/DAY     RAT
        ORAL: DIET         2 YEARS
                           000143-33-9

                             WHOLE BODY
                             THYROID
                             NERVE
                                             DECREASED WEIGHT
                                             EFFECTS
                                             MYELIN DEGENERATION
4E-2
500
                                                                                                           IRIS
                                                                                                                     005640
        SUBCHRONIC  [RfD]  COMMENT:  CALCULATED  BY ANALOGY TO FREE CYANIDE BY  CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.  THE CHRONIC
                                 ORAL [RfD]  WAS ADOPTED AS THE SUBCHRONIC  ORAL  [RfD].
        CHRONIC  [RfD] COMMENT:  CALCULATED BY  ANALOGY TO FREE CYANIDE BY CORRECTING FOR  DIFFERENCES IN  MOLECULAR WEIGHT.
SODIUM DIETHYLDITHIOCARBAMATE
NOEL    30    MG/KG/DAY     RAT
        ORAL: GAVAGE       90 DAYS
                                        000148-18-5
                                     EYE
                                     WHOLE  BODY
SODIUM METAVANADATE
NOAEL   10     PPM        RAT
        ORAL: DRINKING     3 MONTHS
        WATER

STRONTIUM,   STABLE
NOAEL   263.1   MG/KG/DAY  RAT
        ORAL: DRINKING     3 YEARS
        WATER
                           013718-26-8

                             KIDNEY


                           007440-24-6

                             BONE
                                             CATARACTS
                                             DECREASED WEIGHT
                                             IMPAIRED FUNCTION
                                             RACHITIC CHANGES
                                                                                       3E-1
                                                                                       100
1E-2
100
                                                                                                           IRIS
1E-3
1000
                                                                                                           8.8E-1
                                                                                                           300
                                                                                                                     005644
                                                                                                                     005735
                               010406
NOAEL
CHRONIC  [RfD] COMMENT:  BASED ON RACHITIC CHANGES IN  BONE IN A 3-YEAR STUDY IN RATS. UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.

                                                                                                                     010405
524.6  MG/KG/DAY  RAT
ORAL: DRINKING     9 WEEKS
WATER
                                     BONE
                                                     RACHITIC CHANGES
1E+0
300
        SUBCHRONIC  [RfD]  COMMENT:  BASED ON RACHITIC CHANGES  IN BONE IN A 9-WEEK STUDY IN RATS.
IRIS,  EPA'S  INTEGRATED RISK  INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER  SUPPORT: (513)  569-7254, FTS 684-7254.
                                                                                                                                1-65

-------
                         HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY)      January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
     Subchronic             Chronic
  [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
(mg/cu m) Cmg/kg/day)  (mg/cu m)  (mg/kg/day)
   UF         UF       UF         UF
STRYCHNINE
LOAEL/  .2.5  MG/KG/DAY    RAT
PEL     ORAL: GAVAGE      28 DAYS
               000057-24-9

                 UNSPECIFIED
                 UNSPECIFIED

               000100-42-5
STYRENE
NOAEL    200     MG/KG/DAY  DOG
        ORAL: GAVAGE      19 MONTHS   ERYTHROCYTES
                                     LIVER
TOXICITY
H1STOPATHOLOGY
                                 EFFECTS
                                 EFFECTS
            3E-3
            1000
                                          2E+0
                                          100
                                                              IRIS
                                                                                               IRIS
        CHRONIC {RfD]  COMMENT:  UNDER REVIEW, CURRENT  NUMBER SUBJECT  TO CHANGE.
        GENERAL COMMENT:   ALSO SEE HEAST  TABLE 3: CARCINOGENICITY.

SUCCINONITRILE                 000110-61-2
        DATA  INADEQUATE FOR QUANTITATIVE  RISK ASSESSMENT   .

SULFUR OXIDES
        CHRONIC [RfC]  COMMENT:  REFER TO  APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

SULFUR DIOXIDE             007446-09-5
        CHRONIC [RfC]  COMMENT:  REFER TO  APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
SULFURIC  ACID
NOAEL   0.066-  MG/CU M
        0.098
        INHALATION
      HUMAN
               007664-93-9
                 RESPIRATORY
                 SYSTEM
EFFECTS
        CHRONIC  [RfC]  COMMENT:  REPORTED  EFFECTS OCCURRED AT PORTAL OF  ENTRY. ESTIMATES OF MG/DAY REFERENCE DOSES ARE INAPPROPRIATE
                              BECAUSE EFFECTS AT PORTAL OF ENTRY DEPEND ON CONCENTRATION IN AIR. AN ACCEPTABLE AIR CONCENTRATION
                              OF 0.07 MG/CU M WAS ESTIMATED BY CARSON ET AL (1981)  FROM AVAILABLE DATA.
THIOCYANOMETHYLTHIO)-BENZOTHIAZOLE,  2-
         (TCMTB)
NOEL    25   MG/KG/DAY     RAT
        ORAL: DIET         SUBCHRONIC  STOMACH
                                         021564-17-0
                                 LESIONS
                                                                          3E-1
                                                                          100
                                                              3E-2
                                                              1000
        SUBCHRONIC [RfD]  COMMENT:  BASED ON  CONFIDENTIAL  BUSINESS INFORMATION DATA.
        CHRONIC  [RfD] COMMENT:  BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA.
010285
                                           010059
                                                                                                         005585
                                                                                                         910059
                                                                                                         905585
                                                                                                         005647
                                           010068
IRIS,  EPA'S INTEGRATED  RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                    1-66

-------
                        HEAST  TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
                                                                                                                          January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
TEMEPHOS
NOAEL    200     PPM
        ORAL: DIET
                        SPECIES
                   EXPERIMENT LENGTH TARGET
                        RAT
                        99 DAYS
TERBUFOS
NOAEL    0.0025  MG/KG/DAY  DOG
        ORAL: DIET        6 MONTHS
003383-96-8



013071-79-9

  CHOLINESTERASE
                                                  CRITICAL EFFECT
                                                  NONE OBSERVED
                                                  INHIBITION
                                                 Subchronic            Chronic
                                               [RfC]      [RfD]      [RfC]      [RfD]     REFERENCE
                                             (mq/cu m) (mg/kg/day) (ng/cu m)  (mg/kg/day)
        CHRONIC [RfD] COMMENT:  UNDER REVIEW, CURRENT NUMBER SUBJECT  TO CHANGE.

TEREPHTHALIC ACID            000100-21-0
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

TETRACHLOROAZOXYBENZENE     021232-47-3
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TETRACHLOROBENZENE,  1,2,4,5-
NOAEL    0.34    MG/KG/DAY  RAT
        ORAL: DIET        13 WEEKS    KIDNEY
                                            000095-94-3

                                                  LESIONS
TETRACHLOROCYCLOPENTADIENE          000695-77-2
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TETRACHLOROETHANE,  1,1,1,2-
NOAEL   89.3    MG/KG/DAY  RAT
       ORAL: GAVAGE      103 WEEKS   LIVER
                                   KIDNEY
                                          000630-20-6
                                                  LESIONS
                                                  LESIONS
                                                                                  UF
        SUBCHRONIC  [RfD]  COMMENT:  THE CHRONIC ORAL  [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].

                                 000127-18-4

                                   LIVER           HEPATOTOXICITY

        GENERAL  COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGEN 1CITY.
TETRACHLOROETHYLENE
NOAEL    14     MG/KG/DAY  MOUSE
        ORAL             6 WEEKS
TETRACHLOROHYDRAZOBENZENE          071753-42-9
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                            UF
                                                                                                     UF
2E-1
100
2.5E-5
100
                                                        3E-3
                                                        100
                                                                                         3E-2
                                                                                         3000
                                                        1E-1
                                                        100
                                                                                                                UF
2E-2
1000
2.5E-5
100
                    IRIS
                                                                            IRIS
                   IRIS
                                                                                                                       010060
                                                                                                                       010408
                                                                                                                       008881
                                                                                                                       010064
          010286
                                                                                                                      005303
                             010407
                             005650
                                                                                                                      010065
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER  SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                                 1-67

-------
                        HEAST  TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGEHICITY)
                                                                                                                           January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                        SPECIES
                   EXPERIMENT LENGTH TARGET
                                                  CRITICAL EFFECT
    Subchronic             Chronic
  [RfC]     [RfO]      [RfC]       [RfD]     REFERENCE
(mg/cu m) (mg/kg/day)  (mg/cu ro)  (mg/kg/day)
                                                                                  UF
                                                                                             UF
                                                                                                      UF
                                  UF
TETRACHLOROPHENOL,  2,3,4,5-        004901-51-3
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TETRACHLOROPHENOL,  2,3,4,6-
NOAEL   25      MG/KG/DAY  RAT
       ORAL: GAVAGE      90 DAYS
                                         000058-90-2
                                   LIVER
                                   LIVER
                                                  INCREASED WEIGHT
                                                  CENTRILOBULAR HYPERTROPHY
TETRACHLOROPHENOL,  2,3,5,6-        000935-95-5
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

TETRACHLOROPROPENE,  1,1,2,3-       010436-39-2
       DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TETRACHLORVINPHOS  (STIROFOS)
NOEL    3.1  MG/KG/DAY    DOG
       ORAL: DIET        2 YEARS     LIVER
                                   KIDNEY
                                   WHOLE BODY
                                             000961-11-5
                                                  INCREASED WEIGHT
                                                  INCREASED WEIGHT
                                                  DECREASED WEIGHT
       SUBCHRONIC  [RfD]  COMMENT:   THE CHRONIC ORAL [RfO] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
       GENERAL  COMMENT:  ALSO SEE  HEAST TABLE 3: CARCINOGENICITY.
TETRAETHYL  DITHIOPYROPHOSPHATE
NOEL    0.5  MG/KG/DAY    RAT
       ORAL: DIET        3 MONTHS    ERYTHROCYTES

                                   BLOOD
TETRAETHYL  LEAD  (See LEAD ALKYLS)

                                001314-32-5
                                               003689-24-5

                                                  DECREASED CHOLINESTERASE
                                                  ACTIVITY
                                                  DECREASED CHOLINESTERASE
                                                  ACTIVITY
THALLIC  OXIDE
NOAEL   0.22 MG/KG/DAY    RAT
       ORAL:GAVAGE       90 DAYS
                                   LIVER
                                   BLOOD
                                                  INCREASED SCOT
                                                  INCREASED SERUM LDH
           3E-1
           100
           3E-2
           100
           5E-3
           100
           7E-4
           300
       CHRONIC [RfD] COMMENT:  WITHDRAWN FROM IRIS (5/1/89). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
                                                                                                              IRIS
                                                                                                              IRIS
IRIS
7E-5
3000
                                                                                                                       005324
          005323
                                                                                                                       005325
                                                                                                                       010066
          010067
010287
                                                                                                                       005660
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                  1-68

-------
                          HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
                                                                                                                                  January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                          SPECIES
                    EXPERIMENT LENGTH TARGET
                           CRITICAL EFFECT
     Subchronic             Chronic
  [RfC]      [RfD]      [RfC]        [RfD]     REFERENCE
(mg/cu m) (ing/kg/day)  (mg/cu m)  (mg/kg/day)
    UF         UF       UF         UF
THALLIUM (I)  ACETATE          000563-68-8
NOAEL   0.26 MG/KC/DAY     RAT
        ORAL:  GAVAGE       90 DAYS     LIVER
                                     BLOOD
                                                      INCREASED SCOT
                                                      INCREASED SERUM LDH
                                                                      9E-4
                                                                      300
                                                                                                                    IRIS
        SUBCHRONIC  IRfD] COMMENT:   CALCULATED
        CHRONIC  [RfD] COMMENT:   CALCULATED BY
                                            BY ANALOGY TO THALLIUM  SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
                                            ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR  WEIGHT DIFFERENCES.
THALLIUM  (I)  CARBONATE
NOAEL   0.23   MG/KG/DAY  RAT
        ORAL:  GAVAGE       90 DAYS
                                    006533-73-9

                                     LIVER
                                     BLOOD
                            INCREASED SCOT
                            INCREASED SERUM LDH
            8E-4
            300
                                                                                          IRIS
        SUBCHRONIC  {RfD] COMMENT:   CALCULATED
        CHRONIC  [RfD] COMMENT:   CALCULATED BY
                                            BY ANALOGY TO THALLIUM  SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
                                            ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR  WEIGHT DIFFERENCES.
THALLIUM  (I)  CHLORIDE
NOAEL   0.23  MG/KG/DAY    RAT
        ORAL:  GAVAGE       90 DAYS
                                    007791-12-0
                                     LIVER
                                     BLOOD
                                                      INCREASED SCOT
                                                      INCREASED SERUM LDH
                                                                                                8E-4
                                                                                                300
                                                                                          IRIS
                                                                                                                               005664
                                                                                                     005668
                                           005672
        SUBCHRONIC  (RfD] COMMENT:   CALCULATED
        CHRONIC  [RfD] COMMENT:   CALCULATED BY

THALLIUM  (IN SOLUBLE  SALTS)
                                            BY ANALOGY TO THALLIUM  SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
                                            ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR  WEIGHT DIFFERENCES.
        CHRONIC  [RfD] COMMENT:   REFER TO IRIS FOR OTHER THALLIUM SALTS.

                                    010102-45-1
THALLIUM(I)  NITRATE
NOAEL
        0.26 MG/KG/DAY
        ORAL:  GAVAGE
RAT
90 DAYS
                                     LIVER
                                     BLOOD
                                     HAIR
                                                      INCREASED SCOT
                                                      INCREASED SERUM LDH
                                                      ALOPECIA
            9E-4
            300
                                                                                                                    IRIS
                                                                                                                               010458
                                                                                                                               005676
        SUBCHRONIC  [RfD] COMMENT:   CALCULATED
        CHRONIC [RfD] COMMENT:   CALCULATED BY
                                            BY ANALOGY TO THALLIUM  SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
                                            ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR  WEIGHT DIFFERENCES.
IRIS,  ERA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER  SUPPORT: (513)  569-7254, FTS 684-7254.
                                                                                                                                          1-69

-------
                          HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER  THAN CARCINOGENICITY)      January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
     Subchronic             Chronic
  [RfC]      [RfD]       [RfC]       [RfO]     REFERENCE
(mg/cu m) (mg/kg/day) (ma/cu m)  (ma/kg/day)
    UF         UF       UF         UF
THALLIUM SELENITE
NOAEL   0.28  HG/KG/DAY    RAT
        ORAL:  GAVAGE       90 DAYS
               012039-52-0
                 LIVER
                 BLOOD
INCREASED SCOT
INCREASED SERUM LDH
            9E-4
            300
                                                                                                IRIS
                                                                          005680
        SUBCHRONIC  [RfD] COMMENT:   CALCULATED BY ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
        CHRONIC  [RfD] COMMENT:  THE ORAL  [RfD], WHILE  STILL AVAILABLE ON  IRIS, IS BEING RECONSIDERED BY THE  [RfD] WORK GROUP. CALCULATED BY ANALOGY
                               TO THALLIUM SULFATE  BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM(I)  SULFATE
NOAEL   0.25    MG/KG/DAY  RAT
        ORAL:  GAVAGE       90 DAYS
THIOFANOX
NOAEL   0.025   MG/KG/DAY  DOG
        ORAL:  GAVAGE       8 DAYS
               007446-18-6

                 LIVER
                 BLOOD

               039196-18-4

                 CHOL1NESTERASE
INCREASED SCOT
INCREASED SERUM LDH
DECREASED CHOLINESTERASE
ACTIVITY
            8E-4
            300
            3E-4
            100
                                                               IRIS
3E-4
100
        SUBCHRONIC  [RfD] COMMENT:   BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA.
        CHRONIC  [RfD] COMMENT:  UNDER REVIEW, CURRENT NUMBER SUBJECT  TO CHANGE. BASED ON CONFIDENTIAL  BUSINESS INFORMATION DATA.
THIRAM
NOAEL   0.61    MG/KG/DAY  FERRET
        ORAL               24 WEEKS

TIN AND  COMPOUNDS
NOAEL   2000    PPM        RAT
        ORAL:  DIET         2 YEARS
               000137-26-8
                 REPRODUCTION
                 LIVER
                 KIDNEY
                                                                                                                     IRIS
                                 EFFECT
LESIONS
LESIONS
                                                                           6E-3
                                                                           100
            6E-1
            100
6E-1
100
        SUBCHRONIC  [RfD] COMMENT:   CALCULATED BY ANALOGY TO STANNOUS  CHLORIDE BY CORRECTING FOR DIFFERENCES  IN MOLECULAR WEIGHT.
        CHRONIC  [RfD] COMMENT:  CALCULATED BY ANALOGY  TO STANNOUS CHLORIDE BY CORRECTING FOR DIFFERENCES  IN  MOLECULAR WEIGHT.
          005682
                                                                          010069
                                                                         010459

                                                                         010070



                                                                         005688
IRIS,  EPA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER  SUPPORT: (513)  569-7254, FTS 684-7254.
                                                                                                                      1-70

-------
                         HEAST  TABLE  1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY)       January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
                 SPECIES
            EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
                                                             Sifcchronic            Chronic
                                                          [RfC]      [RfO]      [RfC]       [RfD]     REFERENCE
                                                        (cng/cu ro) (cng/kg/day) (mg/cu m)  (mg/kg/day)
                                                                                     UF
                                                                                                UF
                                                                                                         UF
                                                                                                                    UF
TOLUENE
NOAEL    223
       MG/KG/DAY  RAT
ORAL:  GAVAGE       13 WEEKS
NOAEL
LOAEL
40     PPM
INHALATION
88     PPM
INHALATION
HUMAN
                         HUMAN
000108-88-3

  LIVER
  KIDNEY

  CENTRAL
  NERVOUS SYSTEM
  EYES
  NOSE

  CENTRAL
  NERVOUS SYSTEM
ALTERED WEIGHT
ALTERED WEIGHT

EFFECTS

IRRITATION
IRRITATION

NEUROLOGICAL
EFFECTS
        CHRONIC [RfC]  COMMENT:  UNDER REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.

TOLUENE-2,3-DIAMINE           002687-25-4
        DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
TOLUENE-2,5-DIAMINE
NOAEL    56      MG/KG/DAY  RAT
        ORAL: DIET     '   78 WEEKS
                           000095-70-5
                                            NONE OBSERVED
                                                                                             2E+0
                                                                                             100
                                                                                        IRIS
2E+0
100
                                                                                                       4E-1
                                                                                                       300
                                                                    6E-1
                                                                    100
        SUBCHRONIC [RfD] COMMENT:   DETERMINED FROM DATA OBTAINED WITH THE SULFATE SALT.
        CHRONIC [RfD]  COMMENT:  DETERMINED FROM DATA OBTAINED WITH THE SULFATE SALT.
TOLUENE-2,6-DIAMINE
NOAEL    16      MG/KG/DAY  RAT
        ORAL: DIET        2 YEARS
                           000823-40-5
                                                    NONE  OBSERVED
                                                                                     2E-1
                                                                                     100
        SUBCHRONIC [RfD] COMMENT:   DETERMINED FROM DATA OBTAINED WITH THE DIHYDROCHLORIDE.
        CHRONIC [RfD]  COMMENT:  DETERMINED FROM DATA OBTAINED WITH THE DIHYDROCHLORIDE.  '

TOLUENE-3,4-DIAMINE           000496-72-0
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT

TOLUIDINE, M-                  000108-44-1
        DATA  INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
                                                                              6E-1
                                                                              100
                                                                                        2E-1
                                                                                        100
                                                                       010469
005915
                                                                                                  905915
                                                                                                                    010071
                                                                                                                    010073
                                                                                         010074
                                                                                                                    010072
                                                                                                                    010075
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS  684-7254.
                                                                                                                              1-71

-------
                         HEAST TABLE  1:  SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER  THAN CARCIN06ENICITY)       January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
                         SPECIES
                    EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
                                  Subchronic              Chronic
                               [RfC]       [RfD]      [RfC]       [RfO]     REFERENCE
                              (tng/cu ro) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                                                      UF
                                                                                                 UF
                                                      UF
                                                                                                                     UF
TRIALLATE                        002303-17-5
NOAEL   1.275   MG/KG/DAY  DOG
        ORAL: DIET        24 MONTHS   SPLEEN
                                     LIVER
                                                    EFFECTS
                                                    EFFECTS
                                          1.3E-2
                                          100
                                                                                                                   IRIS
        SUBCHRONIC [RfO]  COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].

                                   000615-54-3
TRIBROMOBENZENE,  1,2,4-
NOAEL   5       MG/KG/DAY   RAT
        ORAL: DIET         45 OR 90
                          DAYS
                                     LIVER
                                     LIVER
INCREASED RELATIVE  WEIGHT
ENZYME  INDUCTION
5E-2
100
                                                                                                                   IRIS
TRIBROMETHANE (See  BROMOFORM)
TRICHLOROBENZENE,  1,2,4-
NOAEL    100       PPM     RAT
        ORAL: DRINKING
        WATER
                                         000120-82-1

                                     ADRENAL          INCREASED WEIGHT
                                          1E-2
                                          1000
                    1E-2
                    1000
                                                                                                                             010076
                                                                                                                             010077
008885
        SUBCHRONIC [RfD]  COMMENT:  BASED ON A MULTIGENERATION REPRODUCTION STUDY.
        CHRONIC [RfD]  COMMENT:  BASED ON A MULT I GENERATIONAL REPRODUCTION STUDY. WITHDRAWN FROM IRIS (10/1/89). UNDER REVIEW, NUMBER  SUBJECT TO
                              CHANGE.
        SUBCHRONIC [RfC]  COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC [RfC]  COMMENT:  ALSO SEE HEAST TABLE  2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
TRICHLOROCYCLOPENTADIENE          077323-84-3
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TRICHLOROETHANE,  1,1,1-
NAOEL    500     PPM       GUINEA PIG
        ORAL              6 MONTHS    LIVER
                                        000071-55-6

                                                     HEPATOTOXICITY
                                         9E-1
                                         100
                    9E-2
                    1000
                                                                                                                             005304
005700
        SUBCHRONIC [RfD]  COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION
        CHRONIC  [RfD]  COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. WITHDRAWN  FROM IRIS (8/1/91). UNDER  REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
        SUBCHRONIC [RfC]  COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC  [RfC]  COMMENT:  UNDER REVIEW.  ALSO SEE HEAST TABLE 2: ALTERNATE  METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
        CARCINOGENICITY)
                                                                                                                                       1-72

-------
                         HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
                                                                                                                    January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                 SPECIES
            EXPERIMENT LEMGTH TARGET
                                                   CRITICAL EFFECT
                                                           Subchronic             Chronic
                                                         [RfC]      [RfD]      [RfC]       [RfO]     REFERENCE
                                                       (tng/cu m) (mg/kg/day)  (cng/cu m)  (mg/kg/day)
                                                                                   UF
                                                                                              UF
                                                                                                       UF
                                                                                                                 UF
TRICHLOROETHANE,  1,1,2-
NOAEL    3.9     MG/KG/DAY  MOUSE
        ORAL: DRINKING     90 DAYS
        WATER
                               000079-00-5
                            BLOOD
                                           CLINICAL CHEMISTRY
                                           ALTERATIONS
                                                                  4E-2
                                                                  100
                                                                                                       IRIS
                                                                      005702
        CHRONIC [RfC] COMMENT:  UNDER REVIEW.
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3:  CARCINOGENICITY.
TRICHLOROFLUOROMETHANE
                              000075-69-4
                                                                                                               IRIS
LOAEL
1000 MG/KG/DAY
ORAL: GAVAGE
RAT
6 WEEKS
                                    WHOLE BODY
DECREASED WEIGHT
                                        7E-1
                                        1000
                                                                                                005502

                                                                                                005500
        SUBCHRONIC [RfC] COMMENT:  ALSO SEE HEAST  TABLE 2:  ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
        CHRONIC [RfC] COMMENT:  ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY)
TRICHLORO-2'-HYDROXYDIPHENYL  ETHER, 2,4,4'-          003380-34-5
NOEL     500  MG/KG/DAY     RAT
        ORAL: GAVAGE       4 WEEKS     WHOLE BODY      DECREASED WEIGHT

TRICHLOROPHENOL,  2,3,4-          015950-66-0
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

TRICHLOROPHENOL,  2,3,5-          000933-78-8
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT

TRICHLOROPHENOL,  2,3,6-          000933-75-5
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                    4E+0
                                                                                    100
TRICHLOROPHENOL,  2,4,5-
NOEL    1000       PPM     RAT
        ORAL: DIET        98 DAYS
                                000095-95-4
                            LIVER
                            KIDNEY
                          EFFECTS
                          EFFECTS
                                        1E+0
                                        100
                                                                                              IRIS
                                                                                      IRIS
        CHRONIC [RfC] COMMENT:  THE CHRONIC INHALATION  [RfC]  IS CONSIDERED NOT VERIFIABLE  (7/1/91) BY THE RfD/RfC WORKGROUP.
                                                                                                005492
                                                                                                                 005330
                                                                                                                 005331
                                                                                                                 005332
005329
IRIS,  EPA'S INTEGRATED RISK  INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254,  FTS 684-7254.
                                                                                                                            1-73

-------
                        HEAST TABLE  1: SUBCHRONIC  AND  CHRONIC TOXICITY  (OTHER THAN CARCINOGEN I CITY)      January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                        SPECIES
                   EXPERINENT LENGTH TARGET
                                                  CRITICAL EFFECT
                                Subchronic            Chronic
                              [RfC]     [RfD]      [RfC]       [RfO]     REFERENCE
                            (mg/cu m) (mg/kg/day)  (mg/cu m)  (mg/kg/dav)
                                                                                 UF
                                                                                            UF
                                                                                                    UF
                                                                                                               UF
TRICHLOROPHENOL,  2,4,6-
                                      000088-06-2
                                                                                                   IRIS
       CHRONIC  [RfC]  COMMENT:   THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE  (7/1/91) BY THE RfD/RfC WORKGROUP.

TRICHLOROPHENOL,  3,4,5-          000609-19-8
       DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT

TRICHLOROPHENOXY)  PROPIONIC ACID,  2(2,4,5-          000093-72-1
NOEL    0.75  MG/KG/DAY  DOG
       ORAL: DIET        2 YEARS     LIVER          HISTOPATHOLOGY
                                                                                         8E-3
                                                                                         100
       SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS  THE SUBCHRONIC ORAL [RfD].

                                                     000093-76-5
TRICHLOROPHENOXYACETIC ACID,  2,4,5-
NOEL     10   MG/KG/DAY    RAT
        ORAL: DIET        90 DAYS     KIDNEY
                                   LIVER
                                                  WEIGHT EFFECTS
                                                  WEIGHT EFFECTS
TRICHLOROPROPANE,  1,1,1-          007789-89-1
       DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
TRICHLOROPROPANE,  1,1,2-
NOEL     100      MG/L    RAT
        ORAL: DRINKING    13 WEEKS
        WATER
                                       000598-77-6
                                   LIVER
                                   KIDNEY
                                   THYROID
LESIONS
LESIONS
LESIONS
TRICHLOROPROPANE,  1,2,2-          003175-23-3
       DATA INADEQUATE  FOR QUANTITATIVE RISK ASSESSMENT
TRICHLOROPROPANE,  1,2,3-
NOAEL   8  MG/KG/DAY      RAT
       ORAL: GAVAGE      120 DAYS
                                       000096-18-4
                                   ERYTHROCYTES
                                   BLOOD
                                                  DECREASED COUNT
                                                  ALTERED CHEMISTRIES
                                       1E-1
                                       100
5E-2
300
                                       6E-2
                                       100
                                                           IRIS
                                                                                                            IRIS
                                                                                                            IRIS
                                                                                                            IRIS
                                                                                                                      010461
                                                                                                                      005333
                             010284
                                                                                                                      010179
                                                                                                                      010178
                                                                                                                      005705
                                                                    005708
                                                                                                                      005706
                                                                                                                      005714
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                1-74

-------
                         HEAST  TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY)
                                                                                                                      January 1992
CHEMICAL  DOSE
LEVEL    ROUTE
                 SPECIES
            EXPERIMENT LENGTH  TARGET
                                                    CRITICAL EFFECT
                                       Siijchronic             Chronic
                                     [RfC]      [RfD]      [RfC]      [RfD]     REFERENCE
                                   (mg/cu m) (TO/kg/day) (mg/cu m)  (na/kg/day)
                                                                                    UF
                                                                                               UF
                                                                                                        UF
                                                                                                                   UF
TRICHLOROPROPENE,  1,2,3-
NOEL     18     MG/CU M     DOG
        INHALATION:       66 WEEKS
        INTERMITTENT
                                 000096-19-5

                             EYE             IRRITATION
                                               5E-3
                                               100
        SUBCHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR  OF 0.5.
        CHRONIC [RfD]  COMMENT:   BASED ON ROUTE TO ROUTE  EXTRAPOLATION USING AN ABSORPTION  FACTOR OF  0.5.
TRICHLOROTOLUENE,  ALPHA,2,6-
LOAEL    0.5      PPM      RAT
        ORAL: DIET
                  28 DAYS
                                    LIVER
                                    KIDNEY
                                    THYROID
002014-83-7

      LESIONS
      LESIONS
      LESIONS
TRICHLOROTOLUENE,  2,3,6-
LOAEL    0.5       PPM      RAT
        ORAL: DIET        28 DAYS
                                 002077-46-5
                             LIVER
                             KIDNEY
                             THYROID
      LESIONS
      LESIONS
      LESIONS
5E-5
1000
5E-5
1000
TRICHLORO-1,2,2-TRIFLUOROETHANE,  1,1,2-
                                                    000076-13-1
NOEL
2000  PPM
INHALATION:
INTERMITTENT
                         RAT
                         24 MONTHS
                                    WHOLE BODY
                                                   DECREASED WEIGHT
                                     27E+0
                                     100
3E+0
100
        SUBCHRONIC [RfD] COMMENT:  BASED ON  ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.2.
        CHRONIC [RfC]  COMMENT:   UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
TRIFLURALIN
NOEL     0.75   MG/KG/DAY   DOG
        ORAL: DIET        12 MONTHS
                           001582-09-8
                            LIVER
                            BLOOD
                                                    INCREASED WEIGHT
                                                    METHEMOGLOBINEMIA
                                               7.5E-3
                                               100
        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE  SUBCHRONIC ORAL [RfD].
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY..

TRIMETHYLBENZENES
        DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                    5E-3
                    100
                                                                                                                 IRIS
27E+0
100
                                                                                                         IRIS
                    010078
                                                                                                                   005339
                                                                                                                   005335
010460

010376
                              010080
                                                                                                                   005727
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION: IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                             1-75

-------
                         HEAST  TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY  (OTHER  THAN CARCIN06ENICITY)
                                                                                                                       January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
                 SPECIES
            EXPERIMENT LENGTH TARGET
                                                    CRITICAL EFFECT
                                  Subchronic             Chronic
                               [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
                             (mg/cu m) (ma/kg/day)  (rog/cu m)  (mg/kg/day)
                                                                                     UF
                                                                                        UF
                                                     UF
                       UF
TRINITROBENZENE,  1,3,5-
NOAEL    0.51 MG/KG/DAY     RAT
        ORAL: DRINKING     16 WEEKS
        WATER
                           000099-35-4

                            SPLEEN
INCREASED WEIGHT
        CHRONIC [RfD] COMMENT:   CALCULATED FROM DATA OBTAINED WITH 1,3-DINITROBENZENE.
        SUBCHRONIC [RfD] COMMENT:  CALCULATED  FROM DATA OBTAINED WITH  1.3-DINITROBENZENE.

TRINITROPHENOLS
        DATA INADEQUATE FOR QUANTITATIVE RISK  ASSESSMENT
TRINITROPHENYLMETHYLNITRAMINE
NOAEL    125     MG/KG/DAY  RABBIT
        ORAL: GAVAGE       9 MONTHS
                                        000479-45-8

                             LIVER           HISTOPATHOLOGICAL  EFFECTS
                             KIDNEY          HISTOPATHOLOGICAL  EFFECTS
                             SPLEEN          HISTOPATHOLOGICAL  EFFECTS
TRINITROTOLUENE,  2,4,6-
LOAEL    0.5     MG/KG/DAY  DOG
        ORAL: CAPSULE      26 WEEKS
                                000118-96-7

                             LIVER           EFFECTS
        SUBCHRONIC [RfD] COMMENT:  THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD],
        GENERAL COMMENT:  ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
VANADIUM
NOAEL    5       PPM
        ORAL: DRINKING
        WATER
                           007440-62-2
                 RAT
                 LIFETIME
NONE OBSERVED
VANADIUM  PENTOXIDE
NOAEL    17.85   PPM       RAT
        ORAL: DIET        2.5 YEARS
5E-4
1000
                                         1E-1
                                         1000
                                         5E-4
                                         1000
                                         7E-3
                                         100
CHRONIC  [RfD]  COMMENT:  UNDER REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.

                           001314-62-1

                             HAIR            DECREASED CYSTINE

SUBCHRONIC [RfD]  COMMENT:    THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].

                           036907-42-3
                                         9E-3
                                         100
VANADIUM  SULFATE
        2.24  MG/KG/DAY
        ORAL: DRINKING
        WATER
                 RAT
                 LIFETIME
                                         2E-2
                                         100
                                                             IRIS
                    1E-2
                    10000
                    IRIS
                    7E-3
                    100
                    IRIS
                    2E-2
                    100
010081
                                                                                                                   010082
010377
010416
005739
005743
                                                                                                                   008886
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER  SUPPORT: (513) 569-7254,  FTS 684-7254.
                                                                                                                              1-76

-------
CHEMICAL  DOSE
LEVEL     ROUTE
                  HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN CARCINOGENICITY)

                                                                                                      Chronic
                                                                             [RfC]      [RfD]      [RfC]
                                             CRITICAL EFFECT
                                                                                                                                 January 1992
                  SPECIES
            EXPERIMENT  LENGTH TARGET
     Subchronic
  [RfC]      [RfD]      [RfC]       [RfD]     REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/dav)
                                                                                      UF
                                                                                                 UF
                                                                                                           UF
                                                                                                                      UF
VERNAM
NOEL    1     MG/KG/DAY
        ORAL:  DIET
                  RAT
                           001929-77-7

                             WHOLE BODY       DECREASED WEIGHT

COMMENT:   FORMERLY LISTED AS VERMOLATE.
                                                                                       1E-2
                                                                                       100
VINYL  ACETATE                  000108-05-4
NOAEL    176    MG/CU M    MOUSE
        INHALATION:
        INTERMITTENT
                  104 WEEKS   NASAL  CAVITY
                                             LESIONS
                                                                             2E-1
                                                                             30
                                                                                                         IRIS
        SUBCHRONIC [RfC]  COMMENT:  THE CHRONIC  INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION  [RfC].
NOAEL    100    MG/KG/DAY  RAT
        ORAL: DRINKING     2  YEARS     WHOLE  BODY       ALTERED WEIGHT
        WATER                         KIDNEY          ALTERED WEIGHT

VINYL-1-CYCLOHEXENE,  4-     000100-40-3
        DATA  INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
                                                                                       1E+0
                                                                                       100
WARFARIN
LOAEL    2     MG/DAY
        ORAL
                  HUMAN
                           000081-81-2

                             BLOOD           INCREASED PROTHROMBIN TIME

SUBCHRONIC  [RfD] COMMENT:  THE CHRONIC  ORAL [RfD]  WAS ADOPTED AS THE SUBCHRONIC ORAL  [RfD].
            3E-4
            100
                                IRIS
                                                                                                           1E+0
                                                                                                           100
                                                                                                           IRIS
XYLENE, M-                      000108-38-3
        CHRONIC  [RfC] COMMENT:  THE CHRONIC INHALATION [RfC]  IS CONSIDERED NOT VERIFIABLE  (12/11/91)  BY THE RfD/RfC WORK GROUP.
NOAEL   250    MG/KG
        ORAL:  GAVAGE
                  RAT
                  103 WEEKS   CENTRAL          HYPERACTIVITY
                             NERVOUS  SYSTEM
                             WHOLE BODY       DECREASED WEIGHT
                             WHOLE BODY
                                                                                                           2E+0
                                                                                                           100
NOEL
500     MG/KG
ORAL:  GAVAGE
                  RAT
                  13 WEEKS
                                                     NONE OBSERVED
            4E+0
            100
                                           0100S3
                                                                                                                     010418
                                           010417
                                                                                                                             010084
010409
                                           010468

                                           005755
005755
IRIS,  EPA'S  INTEGRATED RISK  INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER  SUPPORT: (513)  569-7254,  FTS 684-7254.
                                                                                                                                1-77

-------
                       HEAST TABLE  1: SUBCHRONIC AND CHRONIC  TOXICITY  (OTHER THAN CARCIN06ENICITY)
January 1992
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT
XYLENE, MIXTURE 001330-20-7
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT
NOEL 500 MG/KG RAT
ORAL: GAVAGE 13 WEEKS WHOLE BODY DECREASED WEIGHT
XYLENE, 0- 000095-47-6
NOEL 250 MG/KG RAT
ORAL: GAVAGE 103 WEEKS CENTRAL HYPERACTIVITY
NERVOUS SYSTEM
WHOLE BODY INCREASED MORTALITY
NOEL 500 MG/KG RAT
ORAL: GAVAGE 13 WEEKS WHOLE BODY DECREASED WEIGHT
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT
XYLENE, P- 000106-42-3
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT
ZINC (METALLIC) 007440-66-6
LOAEL 2.14 MG/KG/DAY HUMAN
ORAL BLOOD ANEMIA
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
ZINC CYANIDE 000557-21-1
NOAEL 24.3 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT
THYROID EFFECTS
NERVE MYELIN DEGENERATION
[RfC] [RfD] [RfC]
(mg/cu m) (mg/kg/day) (mg/cu m)
UF UF UF
VERIFIABLE (12/11/91) BY THE RfD/RfC WORK
4E+0
100

4E+0
100
VERIFIABLE (12/11/91) BY THE RfD/RfC WORK
VERIFIABLE (12/11/91) BY THE RfD/RfC WORK
2E-1
10

5E-2
500
[RfD]
(mg/kg/day)
UF
GROUP.
IRIS
2E+0
100

GROUP.
GROUP.
2E-1
10

IRIS
REFEREI
005918
005763
005751
005751
010467
010378
005767

010289
SUBCHRONIC [RfO] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
ZINC PHOSPHIDE 001314-84-7
LOAEL 3.48 MG/KG/DAY RAT
ORAL: DIET 13 WEEKS WHOLE BODY DECREASED WEIGHT
WHOLE BODY DECREASED FOOD INTAKE
3E-3
1000
IRIS
010290
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.
       1-78

-------
                         HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN  CARCINOGEN 1CITY)       January 1992

                                                                                       Subchronic             Chronic
CHEMICAL  DOSE            SPECIES                                                    [RfC]       [RfD]      [RfC]       [RfD]     REFERENCE
LEVEL     ROUTE      EXPERIMENT LENGTH TARGET           CRITICAL EFFECT                (mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                                                      UF         UF        UF        UF


ZINEB                             012122-67-7
LOAEL   25    MG/KG/DAY    RAT                                                                   5E-2                 IRIS       010085
        ORAL: DIET        2  YEARS     THYROID          HYPERPLASIA                                500

        SUBCHRONIC [RfD]  COMMENT:  THE CHRONIC ORAL [RfD]  WAS ADOPTED  AS  THE SUBCHRONIC  ORAL [RfD].

        5       PPM       RAT                                                                   7E-3                 7E-3       005739
        ORAL: DRINKING    LIFETIME                    NONE OBSERVED                               100                  100
        WATER
IRIS,  EPA'S INTEGRATED  RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.         1-79

-------
                                HEAST TABLE 2:  ALTERNATE  METHODS -  SUBCHRONIC AND  CHRONIC TOXICITY
                                                          (OTHER THAN CARCINOGENICITY)                                      January 1992

                                                                                          Subchronic             Chronic
CHEMICAL  DOSE             SPECIES                                                      [RfC]      [RfO]       [RfC]       [RfD]     REFERENCE
LEVEL     ROUTE      EXPERIMENT LENGTH TARGET          CRITICAL EFFECT                (mg/cu m) (ing/kg/day) (mg/cu m)  (ma/kg/day)
                                                                                         UF         UF       UF         UF
ACETONE  CYANOHYDRIN           000075-86-5
NOEL    4.0  MG/KG/DAY
                          RAT                                                          1E-1                 1E-2                 010432
        INHALATION:        14 WEEKS    CENTRAL          EFFECTS                          100                  1000
        INTERMITTENT                   NERVOUS  SYSTEM

        SUBCHRONIC [RfC] COMMENT:  4E-2 MG/KG/DAY (SEE APPENDIX A-II,  DOSE CONVERSIONS ON HEAST). AN ERROR IN THE UNCERTAINTY FACTOR THAT WAS
                                  REPORTED IN  HEED (1988) WAS CORRECTED.
        CHRONIC [RfC] COMMENT:  4E-2 MG/KG/DAY  (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC]  VALUES WERE DERIVED FROM METHODOLOGY THAT  IS  NOT CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY.

ACETONITRILE                    000075-05-8
NOAEL   100     PPM        MOUSE                                                        5E-1                 5E-2                 005208
        INHALATION:        92 DAYS     LIVER           INCREASED RELATIVE WEIGHT         300                  3000
        INTERMITTENT

        SUBCHRONIC [RfC] COMMENT:  1E-1 MG/KG/DAY (SEE APPENDIX A-II,  DOSE CONVERSIONS ON HEAST).
        CHRONIC [RfC] COMMENT:  1E-2 MG/KG/DAY  (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). UNDER REVIEW,  CURRENT NUMBER SUBJECT TO CHANGE.
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC]  VALUES WERE DERIVED. FROM METHODOLOGY THAT  IS  NOT CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY.

ACETOPHENONE                    000098-86-2
NOAEL   0.007   MG/CU M    RAT                                                          2E-4                 2E-5                 005211
        INHALATION:        70 DAYS     BLOOD VESSEL     CONGESTION                       100                  1000
        CONTINUOUS                    LIVER           DYSTROPHY
                                      BLOOD           DECREASED AlBUMIN/GLOBULIN
                                                      RATIO

        SUBCHRONIC [RfC] COMMENT:  5E-5 MG/KG/DAY (SEE APPENDIX A-II,  DOSE CONVERSIONS ON HEAST).
        CHRONIC [RfC] COMMENT:  5E-6 MG/KG/DAY  (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC]  VALUES WERE DERIVED FROM METHODOLOGY THAT  IS  NOT CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.          2-1

-------
                                HEAST TABLE 2: ALTERNATE  METHODS -  SUBCHRONIC  AND CHRONIC  TOXICITY
                                                          (OTHER THAN  CARCINOGENICITY)
                                                                                                           January 1992
CHEMICAL  DOSE             SPECIES
LEVEL     ROUTE      EXPERIMENT LENGTH TARGET
                            CRITICAL EFFECT
                                                      Subchronic              chronic
                                                   [RfC]      [RfD]       [RfC]       [RfD]
                                                 (mg/cu m)  (mg/kg/day) (mg/cu m)   (mg/kg/day)
                                                     UF         UF        UF         UF
                                                                                                       REFERENCE
BARIUM
NOEL    0.8 MG/CU M

        INHALATION:
        INTERMITTENT
         007440-39-3
RAT
4 MONTHS
            FETUS
                            FETOTOXICITY
                                                   5E-3
                                                   100
                                                      5E-4
                                                      1000
                                          005249
        SUBCHRONIC [RfC] COMMENT:  1E-3 MG/KG/DAY  (SEE APPENDIX A-II,  DOSE  CONVERSIONS ON HEAST).  BASED ON A REPRODUCTION  STUDY.
        CHRONIC [RfC]  COMMENT:  1E-4 MG/KG/DAY  (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).  BASED  ON A REPRODUCTION  STUDY. UNDER REVIEW, CURRENT
                               NUMBER SUBJECT  TO  CHANGE.
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC  INHALATION [RfC]  VALUES WERE DERIVED FROM  METHODOLOGY THAT IS NOT  CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY.
CHLORO-1,3-BUTADIENE,  2-
NOAEL   10      PPM       RAT
        INHALATION:        2 YEARS
        INTERMITTENT
          000126-99-8

            HAIR
            WHOLE BODY
                  ALOPECIA
                  DECREASED WEIGHT GAIN
                                                   1E-1
                                                   100
                                           2E-2
                                           100
                     1E-1
                     100
           2E-2
           100
005878
        SUBCHRONIC [RfC] COMMENT:  4E-2 MG/KG/DAY  (SEE APPENDIX A-II,  DOSE  CONVERSIONS ON HEAST).
        CHRONIC [RfC]  COMMENT:  4E-2 MG/KG/DAY  (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).   UNDER  REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.
        SUBCHRONIC [RfD] COMMENT:  BASED ON ROUTE  TO ROUTE EXTRAPOLATION ASSUMING AN INHALATION ABSORPTION FACTOR OF 0.5.
        CHRONIC [RfD]  COMMENT:  BASED ON ROUTE  TO  ROUTE EXTRAPOLATION  ASSUMING AN INHALATION ABSORPTION  FACTOR OF 0.5.
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC]  VALUES WERE DERIVED FROM  METHODOLOGY THAT IS NOT  CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.  NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE
                         EXTRAPOLATION TO THE  ORAL  [RfD] VALUES.
CHLOROBENZENE
LOAEL   75 PPM
        INHALATION:
        INTERMITTENT
RAT
120 DAYS
000108-90-7

  LIVER
  KIDNEY
EFFECTS
EFFECTS
2E-1
1000
2E-2
10000
                                                                                                       005353
        SUBCHRONIC [RfC]  COMMENT:  5E-2 MG/KG/DAY  (SEE APPENDIX A-II,  DOSE  CONVERSIONS ON HEAST).
        CHRONIC [RfC]  COMMENT:  5E-3 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). UNDER  REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.
        GENERAL COMMENT:   THE SUBCHRONIC AND CHRONIC  INHALATION [RfC]  VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
                          INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY.
IRIS,  EPA'S INTEGRATED RISK INFORMATION  SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS  USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                   2-2

-------
CHEMICAL
LEVEL
DOSE
ROUTE
                                HEAST TABLE 2:
     SPECIES
EXPERIMENT LENGTH TARGET
                                          ALTERNATE METHODS -  SUBCHRONIC AND CHRONIC  TOXICITY
                                                (OTHER  THAN CARCINOGENICITY)
                                                                                                                                    January 1992
                                                      CRITICAL  EFFECT
     Sifcchronic             Chronic
  [RfC]      [RfD]       [RfC]       [RfD]
Crog/cu m)  (mg/kg/day) (mg/cu m)  (mg/kg/day)
    UF         UF       UF          UF
                     REFERENCE
CYCLOPENTADIENE
NOEL    87.3 MG/KG/DAY
        INHALATION:
        INTERMITTENT

        SUBCHRONIC  [RfC]
        GENERAL COMMENT:
                 RAT
                 194 DAYS
               000542-92-7

                 LIVER
                 KIDNEY
                                            LESIONS
                                            LESIONS
  3E+0
  100
                     005401
               COMMENT:  9E-1 MG/KG/DAY  (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
                THE SUBCHRONIC INHALATION  [RfC] VALUE WAS DERIVED FROM METHODOLOGY THAT IS NOT  CURRENT WITH THE INTERIM
                INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.
DICHLOROBENZENE,
NOEL    49      PPM
        INHALATION:
        INTERMITTENT
             1,2-
                RAT
                UP TO 7
                MONTHS
               000095-50-1
                 WHOLE BODY
                                 DECREASED  WEIGHT GAIN
  2E+0
  100
2E-1
1000
                                                                                                           005412
        SUBCHRONIC  [RfC] COMMENT:  4E-1  MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
        CHRONIC [RfC] COMMENT:  4E-2 MG/KG/DAY (SEE APPENDIX  A-II, DOSE CONVERSIONS ON HEAST).
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION  [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT  CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE  RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY.
DICHLORODIFLUOROMETHANE      000075-71-8
LOAEL   482.3 MG/KG/DAY    GUINEA PIG
        INHALATION:        6 WEEKS     LIVER
        INTERMITTENT
                                            LESIONS
                                                                            2E+0
                                                                            1000
                                                                                      •2E-1
                                                                                      10000
                                           005497
        SUBCHRONIC  [RfC] COMMENT:  5E-1  MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
        CHRONIC [RfC] COMMENT:  5E-2 MG/KG/DAY (SEE APPENDIX  A-II, DOSE CONVERSIONS ON HEAST).
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION  [RfC] VALUES WERE DERIVED FROM  METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE  RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY.
DICHLOROETHANE,
NOEL    138 MG/KG/DAY

        INHALATION:
        INTERMITTENT
            1,1-
                CAT
                13 WEEKS
               000075-34-3
                            KIDNEY
                                            DAMAGE
                                                                 5E+0
                                                                 100
                      5E-1
                      1000
                                                                                                                      005789
        SUBCHRONIC  [RfC] COMMENT:  1E+0  MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
        CHRONIC [RfC] COMMENT:  1E-1  MG/KG/DAY (SEE APPENDIX  A-II, DOSE CONVERSIONS ON HEAST).  UNDER  REVIEW, CURRENT  NUMBER SUBJECT TO CHANGE.
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION  [RfC] VALUES WERE DERIVED FROM  METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
                         INHALATION  METHODOLOGY USED BY THE  RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY AND TABLE 3:
                         CARCINOGENICITY.
IRIS,  EPA'S  INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                                  2-3

-------
                                HEAST  TABLE  2:  ALTERNATE  METHODS - SUBCHRONIC  AND CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)
                                                                                                               January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT  LENGTH TARGET
                                                      CRITICAL EFFECT
                                                     Siijchronic              Chronic
                                                  [RfC]       [RfD]      [RfC]       [RfD]      REFERENCE
                                                (mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                    UF         UF        UF         UF
DICYCLOPENTADIENE
LOAEL   1        PPM
        INHALATION:
        INTERMITTENT
                                    000077-73-6
                          RAT
                          90 DAYS
                                      LIVER
                                                      DYSFUNCTION
                                                                  2E-3
                                                                  1000
                                                                       2E-4
                                                                       10000
                                          005424
        SUBCHRONIC  [RfC] COMMENT:  6E-4  MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
        CHRONIC [RfC] COMMENT:  6E-5 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM  METHODOLOGY THAT IS NOT  CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.  ALSO SEE TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY.
ETHOXYETHANOL  ACETATE,  2-   000111-15-9
NOEL    30.1   G/KG/DAY     RAT
        INHALATION:        DAY 6-18    FETUS
        INTERMITTENT       OF
                          GESTATION
                                 DECREASED OSSIFICATION
                                                            3E-1
                                                            100
                               3E-1
                               100
                                                                                                            005952
        SUBCHRONIC  [RfD] COMMENT:   BASED ON ROUTE TO ROUTE  EXTRAPOLATION. THE ORAL  [RfD] WAS BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS
                                  6-18 OF GESTATION.
        CHRONIC [RfD] COMMENT:  BASED  ON ROUTE TO ROUTE EXTRAPOLATION. THE ORAL  [RfD] WAS BASED ON A REPRODUCTION STUDY  WITH EXPOSURES DURING DAYS 6-
                               18 OF  GESTATION.
        GENERAL COMMENT:  NO PHARMACOK1NETIC DATA WERE PROVIDED TO JUSTIFY ROUTE  TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.  ALSO SEE TABLE 1:
                         SUBCHRONIC AND CHRONIC TOXICITY.
ETHYLENE  DIAMINE
NOAEL   59 PPM
        INHALATION:
        INTERMITTENT
      RAT
      30 DAYS
000107-15-3

  WHOLE BODY

  KIDNEY
  LIVER
                                  INCREASED MORTALITY

                                  LESIONS
                                  LESIONS
1E+0
100
                                                                                                                                005793
        SUBCHRONIC  [RfC] COMMENT:  3E-1  MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
        GENERAL  COMMENT:  THE SUBCHRONIC INHALATION [RfC]  VALUE WAS DERIVED FROM  METHODOLOGY THAT  IS NOT CURRENT WITH THE  INTERIM INHALATION
                         METHODOLOGY USED BY THE RfD/RfC  WORK GROUP.  ALSO SEE TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY.
IRIS,  EPA'S  INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION: IRIS  USER SUPPORT: (513)  569-7254, FTS 684-7254.
                                                                                                                        2-4

-------
                                HEAST TABLE  2: ALTERNATE  METHODS - SUBCHRONIC  AND CHRONIC  TOXICITY
                                                          (OTHER THAN  CARCINOGENICITY)
                                                                                                          January 1992
CHEMICAL  DOSE            SPECIES
LEVEL     ROUTE      EXPERIMENT LENGTH TARGET
                                                      CRITICAL EFFECT
                                                               Subchronic             Chronic
                                                             [RfC]      [RfD]       [RfC]       [RfD]
                                                           (mq/cu ro) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                                              UF          UF       UF         UF
                                          REFERENCE
FURFURAL
NOAEL   20      PPM
        INHALATION:
        INTERMITTENT
HAMSTER
13 WEEKS
          000098-01-1
            NASAL CAVITY
                            OLFACTORY  DEGENERATION
5E-1
100
5E-2
1000
005465
        SUBCHRONIC [RfC]  COMMENT:  1E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE  CONVERSIONS ON HEAST).
        CHRONIC [RfC]  COMMENT:  1E-2 MG/KG/DAY (SEE  APPENDIX A-II, DOSE CONVERSIONS ON HEAST).  UNDER  REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.
        GENERAL COMMENT:   THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES  WERE DERIVED FROM  METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
                          INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY.
METHACRYLONITRILE
NOAEL   3.2 PPM
        INHALATION:
        INTERMITTENT
DOG
90 DAYS
          000126-98-7
            LIVER
                                      LIVER
                            INCREASED  SCOT
                                                       INCREASED SGPT
7E-3
300
7E-4
3000
005812
        SUBCHRONIC [RfC]  COMMENT:  2E-3 MG/KG/DAY (SEE APPENDIX A-II,  DOSE  CONVERSIONS ON HEAST).  THE  [RfC] VALUE DIFFERS FROM THE VALUE CITED IN THE
                                  1987 HEED BECAUSE  THE UNCERTAINTY FACTOR WAS CHANGED TO CORRESPOND  TO THAT USED FOR THE ORAL  [RfD] BY IRIS.
        CHRONIC [RfC]  COMMENT:  2E-4 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).  THE [RfC] VALUE DIFFERS FROM THE  VALUE CITED IN THE
                               1987 HEED BECAUSE THE UNCERTAINTY FACTOR WAS  CHANGED TO CORRESPOND TO  THAT USED FOR THE ORAL [RfD] BY IRIS.
        GENERAL COMMENT:   THE SUBCHRONIC AND CHRONIC  INHALATION [RfC]  VALUES  WERE DERIVED FROM  METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
                          INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY.
METHOXYETHANOL ACETATE,  2-
NOAEL   10 PPM             RABBIT
        INHALATION:        13 WEEKS
        INTERMITTENT
                   000110-49-6
            TESTIS
                            DEGENERATION
           2E-2
           100
                                                                                            2E-3
                                                                                            1000
                     010001
        SUBCHRONIC [RfD]  COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR  OF  0.5. CALCULATED FROM  DATA OBTAINED WITH
                                  METHOXYETHANOL CONVERTED BY MULTIPLYING BY THE MOLECULAR WEIGHT RATIO  (118.13/76.09).
        CHRONIC [RfD]  COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF  0.5.  CALCULATED FROM  DATA OBTAINED WITH
                               METHOXYETHANOL CONVERTED BY MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (118.13/76.09).
        GENERAL COMMENT:   NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD) VALUES.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER  INFORMATION:  IRIS  USER SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                   2-5

-------
                                HEAST  TABLE  2:  ALTERNATE METHODS - SUBCHRONIC  AND CHRONIC  TOXICITY
                                                         (OTHER THAN CARCINOGENICITY)
                                                                                                         January 1992
CHEMICAL  DOSE             SPECIES
LEVEL     ROUTE      EXPERIMENT LENGTH TARGET
                            CRITICAL EFFECT
                                   Sifcchronic             Chronic
                                [RfC]       [RfD]      [RfC]        [RfD]
                              (mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                  UF          UF        UF         UF
                                                                                                     REFERENCE
METHYL ACRYLATE
NOEL    15 PPM
        INHALATION:
        INTERMITTENT
          000096-33-3
RAT
2 YEARS
NONE OBSERVED
3E-2
100
3E-2
100
                                                                          010003
        SUBCHRONIC  [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
        CHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
        GENERAL COMMENT:  NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
METHYL ETHYL KETONE
NOAEL   693     MG/CU M    RAT
        INHALATION:        12 WEEKS
        INTERMITTENT
          000078-93-3
                             NONE OBSERVED
                                                            3E+0
                                                            100
                                                     3E-1
                                                     1000
                               005558
        SUBCHRONIC  [RfC] COMMENT:  9E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
        CHRONIC [RfC] COMMENT:  9E-2 MG/KG/DAY (SEE APPENDIX  A-II, DOSE CONVERSIONS ON HEAST).  UNDER REVIEW, CURRENT  NUMBER SUBJECT TO CHANGE.
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM  METHODOLOGY THAT IS NOT  CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE  RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY.
METHYL  ISOBUTYL KETONE
NOEL    50 PPM            RAT
        INHALATION:        90 DAYS
        INTERMITTENT
          000108-10-1

           LIVER
           KIDNEY
INCREASED WEIGHT
EFFECTS
                                8E-1
                                100
          8E-2
          1000
          005562
        SUBCHRONIC  [RfC] COMMENT:  2E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
        CHRONIC [RfC] COMMENT:  2E-2 MG/KG/DAY (SEE APPENDIX  A-II, DOSE CONVERSIONS ON HEAST).  UNDER REVIEW, CURRENT  NUMBER SUBJECT TO CHANGE.
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM  METHODOLOGY THAT IS NOT  CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE  RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY.
METHYL STYRENE,  ALPHA-
NOEL    970  MG/CU  M       RAT
        INHALATION:        197 DAYS
        INTERMITTENT
           000098-83-9

           LIVER
           KIDNEY
INCREASED WEIGHT
INCREASED WEIGHT
                                           7E-1
                                           100
                     7E-2
                     1000
          010016
        SUBCHRONIC  [RfD] COMMENT:  BASED ON ROUTE TO ROUTE  EXTRAPOLATION USING AN ABSORPTION FACTOR  OF 0.5.
        CHRONIC [RfD] COMMENT:  BASED  ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF  0.5.
        GENERAL COMMENT:  NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL  [RfD] VALUES.
IRIS,  EPA'S  INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT: (513)  569-7254, FTS 684-7254.
                                                                                                                  2-6

-------
                                HEAST TABLE 2:  ALTERNATE METHODS  - SUBCHRONIC  AND CHRONIC TOXICITY
                                                         (OTHER THAN CARCIN06ENICITY)                                     January 1992

                                                                                         Subchronic              Chronic
CHEMICAL  DOSE             SPECIES                                                     [RfC]       [RfD]      [RfC]       [RfO]     REFERENCE
LEVEL     ROUTE      EXPERIHENT LENGTH TARGET           CRITICAL EFFECT                (mg/cu m) (mg/kg/day) (rog/cu in)   (mg/kg/day)
                                                                                        UF         UF        UF         UF


METHYL  STYRENE   (MIXED  ISOMERS)            025013-15-4
LOAEL   11.2 MG/KG/DAY     MOUSE                                                       4E-2                 4E-2                 005566
        INHALATION:        103 WEEKS   NASAL CAVITY     LESIONS                          1000                 1000
        INTERMITTENT

        SUBCHRONIC  [RfC] COMMENT:   1E-2 MG/KG/DAY (SEE APPENDIX A-ll, DOSE CONVERSIONS ON HEAST).
        CHRONIC [RfC] COMMENT:  1E-3 MG/KG/DAY (SEE APPENDIX  A-II, DOSE CONVERSIONS ON HEAST). UNDER  REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION  [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE  RfD/RfC WORK GROUP.

LOAEL   5.6  MG/KG/DAY    . MOUSE                                                                  6E-3                 6E-3       005567
        INHALATION:        103 WEEKS   NASAL CAVITY     LESIONS                                     1000                 1000
        INTERMITTENT

        SUBCHRONIC  [RfD] COMMENT:     BASED ON ROUTE TO ROUTE  EXTRAPOLATION WITH AN ABSORPTION FACTOR  OF 0.5.
        CHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION WITH AN ABSORPTION FACTOR OF 0.5. UNDER REVIEW, CURRENT NUMBER SUBJECT TO
                               CHANGE.
        GENERAL COMMENT:  NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.

METHYLENE BROMIDE              000074-95-3
          (DIBROMOMETHANE)
NOAEL   11      MG/KG/DAY  RAT                                                                    1E-1                 1E-2       010011
        INHALATION:        90 DAYS     BLOOD            INCREASED CARBOXYHEMOGLOBIN                  100                  1000
        INTERMITTENT

        SUBCHRONIC  [RfD] COMMENT:     BASED ON ROUTE TO ROUTE  EXTRAPOLATION, INCLUDING AN ABSORPTION FACTOR OF 0.5.
        CHRONIC [RfD] COMMENT:  BASED ON ROUTE TO ROUTE EXTRAPOLATION, INCLUDING AN ABSORPTION FACTOR OF 0.5. UNDER REVIEW, CURRENT NUMBER  SUBJECT TO
                               CHANGE.
        GENERAL COMMENT:  NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
IRIS,  EPA'S  INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.          2-7

-------
                                HEAST TABLE  2:  ALTERNATE METHODS  - SUBCHRONIC  AND CHRONIC  TOXICITY
                                                          (OTHER THAN CARCINOGENICITY)
                                                                                                               January 1992
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT  LENGTH TARGET
                                                      CRITICAL EFFECT
                                                    Subchronic             Chronic
                                                 [RfC]      [RfO]       [RfC]       [RfO]
                                               (mg/cu m) (ing/kg/day) (mg/cu m)  (ng/kg/day)
                                                   UF         UF       UF          UF
                                                                          REFERENCE
NITROBENZENE
LOAEL   25 MG/CU M
        INHALATION:
        INTERMITTENT
      MOUSE
      90  DAYS
               000098-95-3
BLOOD
ADRENAL
KIDNEY
LIVER
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
2E-2
1000
2E-3
10000
                                                                                           005589
        INHALATION:
        INTERMITTENT
      RAT
      90 DAYS
                                      BLOOD
                                      ADRENAL
                                      KIDNEY
                                      LIVER
                                 HEMATOLOGICAL EFFECTS
                                 LESIONS
                                 LESIONS
                                 LESIONS
        SUBCHRONIC  [RfC] COMMENT:  6E-4  MG/KG/DAY (SEE APPENDIX  A-II, DOSE CONVERSIONS ON HEAST).
        CHRONIC [RfC] COMMENT:  6E-4 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).  UNDER REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION  [RfC] VALUES WERE  DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.   ALSO SEE TABLE 1:   SUBCHRONIC AND CHRONIC TOXICITY.
TRICHLOROBENZENE,  1,2,4-
NOEL    22.3  MG/CU  M      RAT
        INHALATION:        3 MONTHS
        INTERMITTENT
                      000120-82-1

                 LIVER           PORPHYRIA
                                                 9E-2
                                                 100
                                                     9E-3
                                                     1000
                                          010360
        SUBCHRONIC  [RfC] COMMENT:  3E-2  MG/KG/DAY (SEE APPENDIX  A-II, DOSE CONVERSIONS ON HEAST).
        CHRONIC [RfC] COMMENT:  3E-3 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION  [RfC] VALUES WERE  DERIVED FROM METHODOLOGY THAT IS NOT CURRENT .WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.   ALSO SEE TABLE 1:   SUBCHRONIC AND CHRONIC  TOXICITY.
TRICHLOROETHANE,  1,1,1-
NAOEL   500     PPM       GUINEA PIG
        ORAL              6 MONTHS
                     000071-55-6
                                      LIVER
                                                      HEPATOTOXICITY
                                                                  1E+1
                                                                  100
                                                                      1E+0
                                                                      1000
                                                                          005700
        CHRONIC [RfC]  COMMENT:  3E-1  MG/KG/DAY  (SEE APPENDIX A-II, DOSE CONVERSIONS  ON  HEAST). UNDER REVIEW, CURRENT NUMBER  SUBJECT TO CHANGE.
        SUBCHRONIC [RfC] COMMENT:  3E+0 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS  ON HEAST).
        GENERAL COMMENT:  THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
                         INHALATION  METHODOLOGY USED BY THE RfD/RfC WORK GROUP.
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED  MONTHLY. FURTHER INFORMATION: IRIS USER  SUPPORT: (513) 569-7254, FTS 684-7254.
                                                                                                                        2-8

-------
                               HEAST TABLE 2:  ALTERNATE  METHODS -  SUBCHRONIC  AND CHRONIC TOXICITY
                                                        (OTHER THAN CARCIN06ENICITY)
CHEMICAL  DOSE
LEVEL     ROUTE
     SPECIES
EXPERIMENT LENGTH TARGET
                                                                                                             January 1992
                                                     CRITICAL EFFECT
                                  Subchronic              Chronic
                               [RfC]       [RfD]      [RfC]       [RfD]
                              (mg/cu m) (mg/kg/day) (mg/cu m)  (mg/kg/day)
                                 UF         UF        UF         UF
                                                                                                         REFERENCE
TRICHLOROFLUOROMETHANE
LOAEL    1940 MG/KG/DAY    DOG
        INHALATION:        90 DAYS
        CONTINUOUS
                   000075-69-4
                 KIDNEY
                 LUNG
INCREASED BUN
INFLAMMATION
7E+0
1000
                                                                                     7E-1
                                                                                     10000
                                                                        005501
        SUBCHRONIC [RfC]  COMMENT:  2E+0 MG/KG/DAY (SEE APPENDIX A-II,  DOSE CONVERSIONS ON HEAST).
        CHRONIC  [RfC]  COMMENT:  2E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE  CONVERSIONS ON HEAST).
        GENERAL COMMENT:   THE SUBCHRONIC AND CHRONIC INHALATION [RfC]  VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
                         INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.  ALSO SEE TABLE 1:
                         SUBCHRONIC AND CHRONIC TOXICITY.
IRIS,  EPA'S INTEGRATED RISK INFORMATION  SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254,  FTS 684-7254.
                                                                                                                     2-9

-------
                                                        HEAST  TABLE 3: CARCINOGENICITY
                                                                                                                                   January 1992
CHEMICAL ROUTE
                   EXPERIMENT LENGTH
                        SPECIES    TARGET
                                                        CANCER
                                                                                    [SLOPE  FACTOR]
                                                                         [EPA      ORAL     INHALATION
                                                                        GROUP] (mg/kg/dayr'Cmg/kg/day)-
                                                   [UNIT RISK]
                                                  ORAL   INHALATION  REFERENCE
                                                 (ug/L)'1 (ug/cu m)'1
ACEPHATE                         030560-19-1
                                                                          IRIS    IRIS                      IRIS
        General  Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
ACROLEIN
                                    000107-02-8
                                                                          IRIS

        General  Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

                                    000079-06-1
ACRYLAMIDE
        ORAL: DRINKING   2 YEARS
        WATER           RAT
                                                                          IRIS
                         IRIS
           4.5E+0
IRIS
                                                                                                                            010086
                                                                                                                            005001
IRIS    010087
                                    MAMMARY               TUMORS
                                    THYROID               TUMORS
                                    UTERUS                TUMORS
                                    ORAL CAVITY           TUMORS
                                    CENTRAL NERVOUS       TUMORS
                                    SYSTEM

        Inhalation [Slope] Comment:   SEE APPENDIX A-II,  DOSE CONVERSIONS ON  HEAST.
        Inhalation [Unit Risk] Comment:  BASED ON ROUTE  TO  ROUTE EXTRAPOLATION.
        General  Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ACRYLONITRILE
        ORAL
                                    000107-13-1
                                                                          IRIS

                                                                          IRIS

                        HUMAN       LUNG                  TUMORS

        Inhalation [Slope] Comment:   SEE APPENDIX A-II,  DOSE CONVERSIONS ON  HEAST.
                         IRIS
                                                                                                           IRIS
        INHALATION:
        OCCUPATIONAL
                                                                                            2.4E-1
                                                            IRIS
                                           005004

                                           005003
ALACHLOR
        ORAL:DIET
                                    015972-60-8
                                    MULTIPLE SITES
TUMORS
                 B2
8E-2
2.3E-6
       010180
        Oral [Slope] Comment:  UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
        General  Comment:'  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS,  EPA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS  UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                           3-1

-------
                                                       HEAST TABLE 3:  CARCINOGENICITY
                                                                                                                                   January 1992
CHEMICAL ROUTE
                  EXPERIMENT LENGTH
                        SPECIES     TARGET
                                                        CANCER
                                                            [SLOPE FACTOR]
                                                 [EPA      ORAL     INHALATION
                                                GROUP]  (mg/kg/dayr'dng/kg/day)
                                                   [UNIT RISK]
                                                  ORAL   INHALATION  REFERENCE
                                                 (ug/L)-1 (ug/cu m)'1
ALDRIN
        ORAL:  DIET
                        MOUSE
           000309-00-2
           LIVER
CARCINOMA
IRIS
IRIS
1.7E+1
IRIS
IRIS    005006
        Inhalation  [Slope] Comment:  SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        Inhalation  [Unit Risk]  Comment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
        General  Comment:  ALSO SEE  HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ALLYL  CHLORIDE
                                    000107-05-1
                                                                         IRIS
                                                                                                                            010181
        General  Comment: FOR RCRA ACTIVITIES ONLY,  CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 OR (202) 260-4761) FOR RCRA APPROVED NUMERIC
                        ASSESSMENT  OF THIS COMPOUND.
ANILINE
                                    000062-53-3
                                                                          IRIS    IRIS                      IRIS

        General  Comment:  ALSO SEE  HEAST TABLE 1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY).

                                    000140-57-8

                                    LIVER                TUMORS
ARAMITE
        ORAL:  DIET
104 WKS
RAT
                                                                          IRIS
                                                                                 IRIS
                                    2.5E-2
                                 IRIS
                                    IRIS
                                                                                                                             010088
                                010206
        Inhalation  [Slope] Comment:   BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        General  Comment:  ALSO SEE  HEAST TABLE 1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY).
ARSENIC,  INORGANIC
        INHALATION:
        OCCUPATIONAL     HUMAN
                                    007440-38-2

                                    RESPIRATORY SYSTEM
                                                 IRIS
                                                                    5.0E+1
                                                                                   IRIS
                                                                                             IRIS
                                                                    005007
                                                        TUMORS
        Inhalation  [Slope] Comment:   ASSUMED A 30% ABSORPTION OF INHALED ARSENIC. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
          General Comment:  ALSO SEE  HEAST TABLE 1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY).
ASBESTOS
        INHALATION

        ORAL
                                    001332-21-4
                                                                          IRIS

                                                                          IRIS
                                                                                             IRIS
                                                                    005919

                                                                    005010
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT:   (513) 569-7254,  FTS 684-7254.
                                                                                                                                            3-2

-------
                                                       HEAST TABLE 3:  CARCINOGENICITY
                                                                                                                                 January 1992
CHEMICAL ROUTE
                  EXPERIMENT  LENGTH
                       SPECIES
                                   TARGET
                                                       CANCER
                                                           [SLOPE FACTOR]
                                                [EPA      ORAL    INHALATION
                                               GROUP] (mg/kg/dayr'dng/kg/day)-
                                  [UNIT RISK]
                                ORAL   INHALATION  REFERENCE
                                
-------
                                                      HEAST  TABLE 3:  CARCINOGENICITY
                                                                                                              January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
     SPECIES    TARGET
CANCER
            [SLOPE FACTOR]
 [EPA     ORAL     INHALATION
GROUP]  (mg/kg/dayr'dng/kg/dayr1
  [UNIT RISK]
 ORAL   INHALATION  REFERENCE
(ug/L)-1 (ug/cu m)'1
BENZO[A]PYRENE                 000050-32-8
        ORAL: DIET      RAT.MOUSE   FORESTOMACH          TUMORS            IRIS    5.8E+0

        Oral  [Slope]  Comment:  UNDER  REVIEW, NUMBER  SUBJECT TO CHANGE.

        INHALATION:     96.4 WEEKS                                        IRIS
        INTERMITTENT     HAMSTER     RESPIRATORY TRACT     TUMORS
                                                                                      1.7E-4
                                                                        6.1E+0
                                                                   005016
                                                           1.7E-3  007777
        General Comment:  FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION  (FTS 260-4761 or (202) 260-4761) FOR RCRA APPROVED NUMERIC
                        ASSESSMENT OF THIS COMPOUND.
BENZO[B]FLUORANTHENE

BENZO[K]FLUORANTHENE
                 000205-99-2


                 000207-08-9
                 IRIS
                                                                        IRIS
                                                   010183
                                                                                                                         010090
        General Comment:  FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH ASSESSMENT SECTION  (FTS 260-4761 or (202)  260-4761) FOR  RCRA APPROVED NUMERIC
                        ASSESSMENT OF THIS COMPOUND.
BENZOTRICHLORIDE

BENZYL  CHLORIDE
BERYLLIUM
        ORAL

        INHALATION:
        OCCUPATIONAL
                       HUMAN
                 000098-07-7


                 000100-44-7


                 007440-41-7


                 LUNG
                 IRIS     IRIS



                 IRIS     IRIS



                 IRIS     IRIS

                 IRIS
                                                 IRIS
                                                                                                        IRIS
                                  IRIS
                   8.4E+0
                  010092


                  010093


                  005018

           IRIS    005017
TUMORS
        Inhalation [Slope] Comment:   SEE APPENDIX  A-II, DOSE CONVERSIONS ON  HEAST.
        General Comment:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY).
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED  MONTHLY. FURTHER  INFORMATION: IRIS USER SUPPORT:   (513) 569-7254,  FTS 684-7254.
                                                                                                                      3-4

-------
                                                      HEAST TABLE 3:  CARCINOGENICITY
                                                                                                                               January 1992
CHEMICAL ROUTE
                  EXPERIMENT LENGTH
                       SPECIES     TARGET
                                                      CANCER
            [SLOPE FACTOR]
 [EPA     ORAL     INHALATION
GROUP]  (rag/kg/day)-'(mg/kg/day)-
  [UNIT RISK]
 ORAL   INHALATION  REFERENCE
(ug/L)-1 (ug/cu m)'1
BIS(CHLOROMETHYL)  ETHER      000542-88-1
        INHALATION:      10-100
        INTERMITTENT     DAYS
                       RAT         RESPIRATORY SYSTEM    TUMORS
                                                                       IRIS    IRIS
                                                                                         2.2E+2
                                                                                                       IRIS
                                           IRIS   005077
        Oral  [Slope]  Comment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION
        Inhalation [Slope] Comment:  SEE APPENDIX A-II, DOSE  CONVERSIONS  ON HEAST.
BIS(2-CHLOROETHYL)  ETHER    000111-44-4
        ORAL            560 DAYS
                       MOUSE       LIVER
                                                                       IRIS   IRIS
                                                                                         1.1E+0
                                                                                                       IRIS
                                           IRIS   005076
                                                       TUMORS

        Inhalation [Slope] Comment:  BASED ON  ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
BIS(2-CHLOROISOPROPYL)  ETHER 039638-32-9
        ORAL: GAVAGE     2 YEARS
                       MOUSE      LIVER                TUMORS
                                  LUNG                 TUMORS
                                                                              7E-2
                   3.5E-2
 2E-6
1E-5    005080
        Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE  EXTRAPOLATION (50% RESPIRATORY ABSORPTION).
        General Comment:  FORMERLY LISTED AS BIS(2-CHLORO-1-METHYL(ETHYL)ETHER). ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
        CARCINOGENICITY).
BIS(2-ETHYLHEXYL)PHTHALATE  000117-81-7
                                                                       IRIS    IRIS                     IRIS

        General Comment:  ALSO SEE  HEAST TABLE  1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY).

BROMODICHLOROMETHANE          000075-27-4
                                                                       IRIS    IRIS
                                                                                                       IRIS
                                                                                                                        005120
                                                                                                                        005148
        General Comment:  ALSO SEE  HEAST TABLE  1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY).


                                   000590-60-2


                       2 YEARS                                         B2                1.1E-1

                       RAT         LIVER                TUMORS
BROMOETHENE
        (VINYL  BROMIDE)
        INHALATION:
        INTERMITTENT
                                                                                                                 3.2E-5  010094
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT:  (513)  569-7254,  FTS 684-7254.
                                                                                                                                       3-5

-------
                                                        HEAST  TABLE 3: CARCINOGENICITY
                                                                                                                 January 1992
CHEMICAL  ROUTE
EXPERIMENT  LENGTH
     SPECIES     TARGET
                    CANCER
            [SLOPE FACTOR]
 [EPA      ORAL    INHALATION
GROUP]  «ng/kg/day) '(mg/kg/dayr
                                                                                                            [UNIT RISK]
                                                                                                           ORAL   INHALATION  REFERENCE
                                                                                                          (ug/L)-1 (ug/cu m)'1
BROMOFORM
        ORAL:  GAVAGE
      2 YEARS
      RAT
000075-25-2

INTESTINE, LARGE
                                                                          IRIS
         IRIS
                                                                                            3.9E-3
IRIS
IRIS    005150
                                                        ADENOMATOUS POLYP
                                                        AOENOCARCINOMA
        Inhalation  [Slope] Comment:   BASED ON ROUTE TO ROUTE EXTRAPOLATION.  SEE APPENDIX A-I1,  DOSE CONVERSIONS ON HEAST.
        General  Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
BUTADIENE,1,3-
        INHALATION:
        INTERMITTENT
                                                       IRIS
                                                         1.8E+0
                                                                                                   IRIS
                                                     009991
                                    000106-99-0

                        MOUSE       MULTIPLE SITES       TUMORS

        Inhalation  [Slope] Comment:   SEE APPENDIX A-II,  DOSE CONVERSIONS ON  HEAST.

BUTYL  BENZYL PHTHLATE, N-   000085-68-7
                                                                          IRIS

        General  Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).

CADMIUM                           007440-43-9
                                                                                                                             005020

        Oral  [Slope] Comment:  THERE  IS INADEQUATE EVIDENCE TO QUANTITATIVELY EVALUATE THE CARCINOGENICITY OF THIS COMPOUND BY THE ORAL  ROUTE.
                                                                                                                             005122
        INHALATION:
        OCCUPATIONAL
                                                       IRIS
                                                         6.1E+0
                                             IRIS    005019
      HUMAN
                 RESPIRATORY SYSTEM
                     TUMORS
        Inhalation  [Slope] Comment:   SEE APPENDIX A-II,  DOSE  CONVERSIONS ON HEAST.
        General  Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CAPTAFOL
        ORAL:  DIET
      MOUSE
002425-06-1
LYMPHATIC SYSTEM
                                      LYMPHOSARCOMA
                                                               8.6E-3
                                   2.4E-7
                                                                                                                             010095
        Oral [Slope] Comment:  UNDER REVIEW, NUMBER SUBJECT  TO CHANGE.
        General  Comment:  ALSO SEE HEAST  TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS  USER SUPPORT:  (513)  569-7254, FTS 684-7254.
                                                                                                                         3-6

-------
                                                       HEAST TABLE 3:  CARCINOGENICITY
                                                                                                                                 January 1992
CHEMICAL ROUTE
                  EXPERIMENT LENGTH
                        SPECIES     TARGET
                                                       CANCER
                                                           [SLOPE FACTOR]
                                                [EPA      ORAL    INHALATION
                                               GROUP] (mg/tg/day)-'(mg/kg/day)-
                                  [UNIT RISK]
                                ORAL   INHALATION  REFERENCE
                                (ug/L)-1 (ug/cu •)-'
CAPTAN
                                   000133-06-2
                                   MULTIPLE SITES
        ORAL:  DIET                  MULTIPLE SITES        TUMORS           B2      3.5E-3

        Oral  [Slope] Comment:  UNDER REVIEW, NUMBER SUBJECT TO CHANGE.

        General Comment:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY).

                                   000086-74-8

                                                        TUMORS
                                                                                 1.0E-7
                                                  010184
CARBAZOLE
        ORAL: DIET
96 WEEKS
MOUSE
82
2E-2
CARBON TETRACHLORIDE
        ORAL:  GAVAGE
                                   LIVER

                                   000056-23-5
                                   LIVER
                                                        TUMORS
                                                                        IRIS
                                                                                IRIS
                                                                   5.3E-2
5.7E-7
                                                                                                         IRIS
010096
                                           IRIS    005022
        Inhalation  [Slope]  Comment:  SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        Inhalation  [Unit Risk] Garment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. INCORPORATES AN ABSORPTION FACTOR OF 0.4.
        General Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN CARCINOGENICITY).
CHLORANIL
        ORAL: DIET
CHLORDANE
        ORAL:  DIET
                        82 WEEKS
                        MOUSE
                        MOUSE
           000118-75-2

           LIVER
           LUNG

           000057-74-9
           LIVER
                                                        TUMORS
                                                        TUMORS
                                                        CARCINOMA
                                                                        IRIS
       4.03E-1
                                                                                IRIS
                   1.3E+0
                         1.2E-5
                                                                                                         IRIS
                  010097
                                   IRIS    005024
        Inhalation  [Slope]  Comment:  BASED ON ROUTE TO ROUTE  EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON  HEAST.
        General Comment:  ALSO SEE HEAST TABLE  1: SUBCHRONIC  AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHLORO-2-METHYLANILINE HYDROCHLORIDE,  4-
        ORAL:  DIET       18 MONTHS
                        MOUSE      CARDIOVASCULAR
                                   SYSTEM
                                   CARDIOVASCULAR
                                   SYSTEM
                                                           003165-93-3
                                                                        B2
                                                        4.6E-1
                                 1.3E-5
                                           010419
                                                        HEMANGIOMA

                                                        HEMANGIOSARCOMA
IRIS,  ERA'S  INTEGRATED RISK  INFORMATION  SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                                         3-7

-------
                                                      HEAST TABLE  3:  CARCINOGENICITY
                                                                                                                              January 1992
CHEMICAL ROUTE
                  EXPERIMENT LENGTH
                       SPECIES     TARGET
                                                      CANCER
            [SLOPE FACTOR]
 [EPA     ORAL     INHALATION
GROUP]  (mg/kg/dayr'(mg/kg/day)
  [UNIT RISK]
 ORAL   INHALATION  REFERENCE
(ug/L)-1 (ug/cu m)'1
CHLORO-2-METHYLANILINE,  4-   000095-69-2
        ORAL: DIET      18 MONTHS
                       MOUSE      CARDIOVASCULAR
                                  SYSTEM
                                  CARDIOVASCULAR
                                  SYSTEM
                                                                       B2
         5.8E-1
 1.6E-5
                                                                                                                        010098
                                                       HEMANGIOMA

                                                       HEMANGIOSARCOMA
        Oral  [Slope]  Comment:   BASED ON VASCULAR TUMORS IN MICE TREATED WITH 4-  CHLORO-2-METHYLANILINE  HYDROCHLORIDE.

CHLORODIBROMOMETHANE  (See DIBROMOCHLOROMETHANE)

CHLOROETHENE  (See  VINYL  CHLORIDE)

                                  000067-66-3
CHLOROFORM
        ORAL: DRINKING
        WATER

        ORAL: GAVAGE
                       78 WEEKS
                       MOUSE
                                                                       IRIS
                                                                       IRIS
         IRIS
                                                                                                       IRIS
                                                                                         8.1E-2
                  005036
                                           IRIS    005035
                                  LIVER
                                                      CARCINOMA
        Inhalation [Slope] Comment:  BASED ON  ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        General Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOX1CITY (OTHER THAN CARCINOGENICITY).
CHLOROMETHANE
        INHALATION:      24 MONTHS
        INTERMITTENT     MOUSE
                                  000074-87-3
                                  KIDNEY
                                                                              1.3E-2
                                                                                         6.3E-3
                                 3.7E-7
           1.8E-6  005038
                                                       TUMORS
        Oral  [Slope]  Comment:   BASED ON ROUTE  TO ROUTE EXTRAPOLATION.
        General Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHLOROMETHYL  METHYL  ETHER  000107-30-2
                                                                       IRIS
                                                                                                                        005081
        General Comment: FOR RCRA ACTIVITIES ONLY, CONTACT  THE HEALTH ASSESSMENT  SECTION (FTS 260-4761 OR (202) 260-4761) FOR RCRA APPROVED NUMERIC
                       ASSESSMENT OF THIS COMPOUND.
CHLORONITROBENZENE, 0-      000088-73-3
        ORAL: DIET       18 MONTHS
                       MOUSE      LIVER
                                                                       B2
         2.5E-2
 7.1E-7
                                                                                                                        010099
                                                       TUMORS
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT:   (513) 569-7254,  FTS 684-7254.
                                                                                                                                      3-8

-------
                                                      HEAST TABLE  3:  CARCINOGENICITY
                                                                                                              January 1992
CHEMICAL  ROUTE
EXPERIMENT LENGTH
     SPECIES    TARGET
                                                       CANCER
                                                                                  [SLOPE FACTOR]
                                                                       [EPA     ORAL     INHALATION
                                                                       GROUP] (ng/kg/dayr'dog/kg/dayr
                          [UNIT RISK]
                         ORAL   INHALATION
                        (ug/L)'1 (ug/cu m)'1
                                                                                                                          REFERENCE
CHLORONITROBENZENE,  P-       000121-73-3
        ORAL: DIET       18 MONTHS
CHLORTHALONIL
        ORAL: DIET
                        MOUSE
      27-32
      MONTHS
      RAT
                 CARDIOVASCULAR       TUMORS
                 SYSTEM

                 001897-45-6
                                   KIDNEY               TUMORS
                                                      B2
                                                                        B2
                                                                               1.8E-2
1.1E-2
                         5.1E-7
3.1E-7
                  010100
010384
        Oral  [Slope] Garment:  UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
        General Comment:   ALSO SEE HEAST  TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
CHROMIUM(VI)
        INHALATION:
        OCCUPATIONAL
                                                      IRIS
                                   018540-29-9

                        HUMAN       LUNG                 TUMORS

        Inhalation [Slope] Comment:  SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.

CHRYSENE                         000218-01-9
                                                                        IRIS
           4.1E+1
                                                                                                IRIS
                                                                                                        005091
                                                                                                                          010185
        General Comment:   FOR RCRA ACTIVITIES ONLY,  CONTACT THE HEALTH'ASSESSMENT  SECTION (FTS  260-4761 OF  (202) 260-4761)  FOR RCRA APPROVED NUMERIC
                         ASSESSMENT OF  THIS COMPOUND. ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
COKE OVEN  EMISSIONS
        INHALATION:
        OCCUPATIONAL     HUMAN
                 008007-45-2

                 LUNG
                                                                                          2.2E+0
                                   IRIS
                 005039
                                                       TUMORS
        Inhalation [Slope] Comment:  SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        General Comment:   FORMERLY LISTED UNDER COAL TARS.
CREOSOTE,  COAL TAR
                 008001-58-9
                                                                        IRIS
                                                                                                       .005042
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                      3-9

-------
                                                      HEAST TABLE 3:  CARCINOGENICITY
                                                                                                                                 January 1992
CHEMICAL ROUTE
CRESOL, M-
                  EXPERIMEMT LENGTH
                       SPECIES     TARGET
                               CANCER
                                   000108-39-4
            [SLOPE FACTOR]
 [EPA      ORAL     INHALATION
GROUP]  (ing/kg/day) '(mg/kg/day)
                                                                        IRIS
  [UNIT RISK]
 ORAL   INHALATION  REFERENCE
(ug/L)-1 (ug/cu •)-'
        General Comment:   ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER  THAN CARCINOGENICITY).

CRESOL, 0-                      000095-48-7
                                                                         IRIS

        General Comment:   ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER  THAN CARCINOGENICITY).

CRESOL, P-                      000106-44-5
                                                                         IRIS

        General Comment:   ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER  THAN CARCINOGENICITY).

                                   000123-73-9

                                   LIVER                TUMOR

        Oral  [Slope] Comment:  UNDER REVIEW, NUMBER SUBJECT TO CHANGE.

                                   000072-54-8
CROTONALDEHYDE
        ORAL: DRINKING   113 WKS
        WATER            RAT
                                                 IRIS    1.9E+0
                                  5.4E-5
ODD


DDE


DDT
        ORAL: DIET
            000072-55-9

            000050-29-3
MOUSE,  RAT   LIVER
                                                        TUMORS
                                                                         IRIS    IRIS
                                                                         IRIS    IRIS
                                                                         IRIS    IRIS
                                                                                           3.4E-1
                                                                                  IRIS
                                  IRIS
                                  IRIS
        Inhalation [Slope]  Comment:  BASED  ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        General Comment:   ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                                                           010187
                                                                                                                           010186
                                                                                                                           010188
                  010190
                                                    010291
                  010292
           IRIS   005044
IRIS,  EPA'S  INTEGRATED  RISK INFORMATION  SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER  SUPPORT:  (513)  569-7254, FTS 684-7254.
                                                                                                                                         3-10

-------
                                                     HEAST TABLE  3: CARCINOGENICITY
                                                                                                                              January 1992
CHEMICAL ROUTE
                  EXPERIMENT LENGTH
                       SPECIES     TARGET
                                                      CANCER
                                                          [SLOPE FACTOR]
                                               [EPA      ORAL     INHALATION
                                              GROUP]  (rag/kg/dayr'dng/kg/dayr
                          [UNIT RISK]
                         ORAL   INHALATION  REFERENCE
                        (ug/Lr1 (ug/cu n)'1
DECABROMODIPHENYL  ETHER     001163-19-5
        (DECABROMODIPHENYL  OXIDE)
                                                                       IRIS
        General Conment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

                                  002303-16-4
                                                                       B2
                                                      TUMORS

DIBENZO[A,H]ANTHRACENE      000053-70-3
                                                                       IRIS
DIALLATE
        ORAL
19 MONTHS
MOUSE       LIVER
6.1E-2
1.7E-6
                                                                                                                       010102
010103
                                                                                                                       010191
        General Comment:  FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 OR (202) 260-4761) FOR RCRA APPROVED  NUMERIC
               ASSESSMENT OF THIS COMPOUND.
DIBROMO-3-CHLOROPROPANE,  1,2-    000096-12-8
        ORAL: DIET      RAT        STOMACH             TUMORS
                                  KIDNEY               TUMORS
                                  LIVER               TUMORS
        INHALATION:
        INTERMITTENT
                       RAT, MOUSE  NASAL CAVITY
                                                      TUMORS
        [EPA Group]  Comment:  UNDER REVIEW,  NUMBER SUBJECT TO CHANGE.
DIBROMOCHLOROMETHANE         000124-48-1
        ORAL: GAVAGE    105 WEEKS
                       MOUSE      LIVER
                                                                       B2
                                                                       B2
                                                                       B2
                                                       1.4E+0
                         4E-5
                                                                  2.4E-3
                                                       8.4E-2
                         2.4E-6
                 010294
                                  6.9E-7  009994
                 005152
                                                      TUMORS
        General Comment:  FORMERLY LISTED AS  CHLORODIBROMOMETHANE.  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER  THAN
        CARCINOGENICITY).
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION: IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                     3-11

-------
                                                      HEAST TABLE 3:  CARCINOGEN1CITY
                                                                                                                       January 1992
CHEHICAL ROUTE
          EXPERIMENT LENGTH
               SPECIES    TARGET
                                                      CANCER
            [SLOPE FACTOR]
 [EPA     ORAL     INHALATION
GROUP] (mg/kg/day)-'(B9/kg/day)
  [UNIT RISK]
 ORAL   INHALATION  REFERENCE
(U3/L)-1 (ug/CU •»-'
DIBROMOETHANE,  1,2-
        ORAL
                           000106-93-4
                                                               IRIS    IRIS

                                                               IRIS

                          NASAL CAVITY          TUMORS

Inhalation [Slope] Comment:  SEE APPENDIX A-II, DOSE  CONVERSIONS ON HEAST.
        INHALATION:      88-103
        INTERMITTENT     WEEKS
                       RAT
                   7.6E-1
DICHLORO-2-BUTENE,  1,4-      000764-41-0
        INHALATION:      90 DAYS
        INTERMITTENT    RAT         NASAL PASSAGES        TUMORS

        General Cotnnent:   FORMERLY  LISTED UNDER DICKLOROBUTENES
                                                               B2
                   9.3E+0
DICHLOROBENZENE,  1,4-        000106-46-7
        ORAL: GAVAGE     103 WEEKS
                       MOUSE       LIVER
                                                                      2.4E-2
                                               TUMORS
                                 IRIS
                                 6.8E-7
        Oral  [Slope]  Comment:  UNDER REVIEW,  NUMBER SUBJECT TO CHANGE.
        General Comment:  ALSO SEE  HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY).
DICHLOROBENZIDINE,3,3'-      000091-94-1

DICHLOROETHANE,  1,1-          000075-34-3
                                                               IRIS    IRIS
                                                                       IRIS
                                                                                               IRIS
        General Comment:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHROMIC TOXICITY  (OTHER THAN  CARCINOGENICITY).
DICHLOROETHANE,  1,2-         000107-06-2
        ORAL: GAVAGE    78 WEEKS
                       RAT        CIRCULATORY SYSTEM    SARCOMA
                                                               IRIS    IRIS
                                                                                 9.1E-2
                                                                                               IRIS
           IRIS
005818

005071
           2.6E-3  005053
        Inhalation [Slope] Comment:  BASED ON  ROUTE TO ROUTE EXTRAPOLATION. SEE  APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
                  005050
                                                                                                                 005815
                                                                                                                 005055
                                           IRIS    005058
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                              3-12

-------
                                                       HEAST  TABLE 3: CARCINOGENICITY
                                                                                                                                 January 1992
CHEMICAL ROUTE
                  EXPERIMENT  LEHGTH
                        SPECIES     TARGET
                    CANCER
                           [SLOPE FACTOR]
                [EPA      ORAL     INHALATION
               GROUP] (mg/kg/dayr'dng/kg/day)-
  [UNIT RISK]
 ORAL   INHALATION  REFERENCE
(ug/L)'1 (ug/cu a)'1
DICHLOROETHYLENE,  1,1-
        ORAL
                                   000075-35-4
        INHALATION
                        12 MONTHS
                        MOUSE
                                     IRIS

                                     IRIS
                                                                                IRIS
                                                                                                         IRIS
                                                                                           1.2E+0
                                                            IRIS
                  005060

                  005059
                                   KIDNEY
                                                        ADENOCARCINOMA
        Inhalation  [Slope]  Comment:  SEE APPENDIX A-II, DOSE  CONVERSIONS ON  HEAST.
        General Comment:  ALSO SEE HEAST TABLE  1: SUBCHRONIC  AND CHRONIC TOX1CITY (OTHER THAN CARCINOGENICITY).
DICHLOROMETHANE  (See  METHYLENE  CHLORIDE)

                                   000078-87-5

                                   LIVER                TUMORS

        Oral  [Slope] Comment:  UNDER REVIEW,  NUMBER SUBJECT TO CHANGE.
DICHLOROPROPANE,  1,2-
        ORAL: GAVAGE
                        MOUSE
                                     B2
                        6.8E-2
 1.9E-6
005062
DICHLOROPROPENE,   1,3-        000542-75-6
        ORAL:  GAVAGE     104 WEEKS
                        RAT        FORESTOMACH           TUMORS
                                   LIVER                TUMORS
                                   ADRENAL              TUMORS
                                   THYROID              TUMORS

        Oral  [Slope] Comment:   UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
                                                                         IRIS
                                             1.8E-1
                                                                                                         5.1E-6
                                                                   010105
        INHALATION:
        INTERMITTENT
                        2 YEARS
                        MOUSE
                                                                         IRIS
                                                                                           1.3E-1
                                                                                3.7E-5  010104
LUNG
ADENOMA
        Inhalation  [Unit Risk]  Comment:  BASED  ON BENIGN LUNG TUMORS IN MICE.
        General  Comment:  ALSO SEE HEAST TABLE  1: SUBCHRONIC.AND CHRONIC TOXICITY (OTHER THAN  CARCINOGENICITY).
DIELDRIN
        ORAL:  DIET
                        MOUSE
                                   000060-57-1

                                   LIVER
                                      IRIS
                                             IRIS
                                    1.6E+1
 IRIS
                                                                                IRIS    005816
                                                        CARCINOMA
        Inhalation  [Slope] Comment:  SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        Inhalation  [Unit Risk]  Comment:  BASED ON ROUTE-TO-ROUTE  EXTRAPOLATION.
        General  Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND  CHRONIC TOXICITY  (OTHER THAN  CARCINOGENICITY).
IRIS, EPA'S  INTEGRATED RISK  INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                         3-13

-------
                                                    HEAST  TABLE 3:  CARCINOGENICITY
                                                                                                                           January 1992
CHEMICAL ROUTE
                 EXPERIMENT LENGTH
                      SPECIES     TARGET
CANCER
           [SLOPE FACTOR]
 [EPA     ORAL    INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)-
  [UNIT RISK]
 ORAL   INHALATION  REFERENCE
(ug/L)-1 (ug/cu m)'1
DIETHYLSTILBESTEROL
       ORAL:DIET        MOUSE
                                  000056-53-1
                                  MAMMARY  GLAND
DIMETHOXYBENZIDINE,  3,3'-   000119-90-4
       ORAL: DIET       LIFETIME
                       HAMSTER     FORESTOMACH
                                                     CARCINOMA
                                                     PAPILLOMA
DIMETHYLANILINE  HYDROCHLORIDE,  2,4-    021436-96-4
       ORAL: DIET       18 MONTHS
                       MOUSE      LUNG                TUMORS
DIMETHYLANILINE,  2,4-        000095-68-1
       ORAL: DIET       18 MONTHS
                       MOUSE       LUNG
                                                                     B2
                       4.7E+3
                       1.4E-2
                                                                            5.8E-1
                                                                            7.5E-1
                                1.3E-1
                                4E-7
                                               1.7E-5
                                               2.1E-5
                                                     TUMORS

       Oral [Slope] Comment:  BASED ON A STUDY USING 2,4-DIMETHYLANILINE HYDROCHLORIDE RESULTING IN LUNG TUMORS IN MICE.

DIMETHYLBENZ[A]ANTHRACENE, 7,12-        000057-97-6
                  010296
                  010106
                                                 010108
                                                 010107
                                                                                                                     010297
       General  Comment:   FOR RCRA ACTIVITIES ONLY, CONTACT THE  HEALTH ASSESSMENT SECTION (FTS 260-4761 OR (202) 260-4761) FOR  RCRA APPROVED NUMERIC
                        ASSESSMENT OF THIS COMPOUND.
DIMETHYLBENZIDINE,  3,3'-    000119-93-7
       ORAL: GAVAGE     30 DAYS
                       RAT         MAMMARY
                                                                     B2
                       9.2E+0
                                2.6E-4
                  010109
                                                     TUMORS
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT:  (513)  569-7254,  FTS 684-7254.
                                                                                                                                  3-14

-------
                                                      HEAST TABLE 3:  CARCINOGENICITY
                                                                                                            January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
     SPECIES    TARGET
                                                      CANCER
            [SLOPE FACTOR]
 [EPA     ORAL     INHALATION
GROUP]  (mg/kg/day)-'(og/kg/day)
  [UNIT RISK]
 ORAL   INHALATION  REFERENCE
(ug/L)' (ug/cu n)'
DIMETHYLHYDRAZINE,   1,1-      000057-14-7
        ORAL: DRINKING   LIFETIME
        WATER           HOUSE       CARDIOVASCULAR
                                   SYSTEM
                                                     B2
        INHALATION:
        INTERMITTENT     MOUSE
                                  RESPIRATORY
                                  SYSTEM
                                     SARCOMA
                                     TUMORS
        [EPA Group]  Comment:  UNDER REVIEW, NUMBER SUBJECT  TO CHANGE.
DIMETHYLHYDRAZINE,1,2-       000077-78-1
        ORAL: DRINKING   LIFETIME
        WATER           MOUSE       CARDIOVASCULAR
                                   SYSTEM
                                                     B2
                                     TUMORS
        Inhalation [Slope] Comment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.

DIMETHYL  SULFATE              000077-78-1
DINITROTOLUENE,  2,4-
                 000121-14-2
         2.6E+0
                   3.5E+0
        3.7E+1     3.7E+1
                                                                       IRIS
                                                                       IRIS   IRIS
 7.4E-5
                                                                                                       IRIS
010110
           1E-3    009992
 1.1E-3     1.1E-2  009993
                                                                                                      010112
                                                                                                                        005066
        General Comment:  LISTED AS "DINITROTOLUENE MIXTURE 2,4-/2,6-" ON IRIS.  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
        CARCINOGENICITY).
DINITROTOLUENE,  2,6-
                 000606-20-2
                                                                       IRIS   IRIS
                                                                                                       IRIS
                                                                                                                        005068
        General Comment:  LISTED AS  "DINITROTOLUENE MIXTURE, 2,4-/2,6-" ON IRIS.  ALSO SEE HEAST TABLE 1: SUBCHRONIC  AND CHRONIC TOXICITY  (OTHER THAN
        CARCINOGENICITY).
DIOXANE,  1,4-
                 000123-91-1
                                                                       IRIS   IRIS
                                                                                     IRIS
                                                  010298
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                    3-15

-------
                                                       HEAST TABLE 3:  CARCINOGENICITY
                                                                                                                                 January 1992
CHEMICAL ROUTE
                  EXPERIMENT LENGTH
                       SPECIES     TARGET
                               CANCER
            [SLOPE FACTOR]
 [EPA      ORAL     INHALATION
GROUP]  (mg/kg/day)-'(mg/kg/day)-
  QJNIT RISK]
 ORAL   INHALATION  REFERENCE
(ug/L)-1 (ug/cu m)'1
DIPHENYLHYDRAZINE,  1,2-     000122-66-7
        ORAL: DIET       2 YEARS
                        RAT         LIVER
                                                                        IRIS    IRIS
                                                                                           8.0E-1
                                                                                                         IRIS
                                                                                            IRIS    005070
                                                        TUMORS

        Inhalation [Slope]  Comment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
DIRECT BLACK  38                001937-37-7
        ORAL: DIET       93 DAYS
                        RAT         LIVER                 TUMORS

        Oral  [Slope]  Comment:  UNDER REVIEW, NUMBER SUBJECT TO CHANGE.

                                   002602-46-2

                                                        TUMORS

        Oral  [Slope]  Comment:  UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
                                                                                8.6E+0
                                                                                 2.4E-4
DIRECT BLUE  6
        ORAL: DIET
91 DAYS
RAT        LIVER
         8.1E+0
 2.3E-4
DIRECT BROWN  95                016071-86-6
        ORAL: DIET       91 DAYS
                        RAT         LIVER                 TUMORS

        Oral  [Slope] Comment:  UNDER REVIEW, NUMBER SUBJECT TO CHANGE.

DIRECT SKY BLUE  6B            002610-05-1
                                                                                9.3E+0
                                                                                 2.6E-4
                                                                        B2
                                                   010113
010114
                                                    010115
                                                                                                                           010116
        [EPA Group] Comment:  BASED ON THE  FACT THAT 3,3-DIMETHOXYBENZIDENE, A KNOWN EPA GROUP 82 CARCINOGEN, IS A METABOLITE OF DIRECT SKY BLUE 6B.

                                   000106-89-8
EPICHLOROHYDRIN
        ORAL: DRINKING
     •   WATER
        INHALATION:      30 DAYS,
        INTERMITTENT     OBSERVED
                        FOR
                        LIFETIME
                        RAT
                                                                        IRIS    IRIS

                                                                        IRIS
                                                                                                         IRIS
                                                                   4.2E-3
                                                   010198

                                            IRIS   010117
                                   NASAL  CAVITY
                                TUMORS
        Inhalation [Slope]  Comment:  SEE APPENDIX A-II,  DOSE CONVERSIONS  ON HEAST.
        General Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC  TOXICITY (OTHER  THAN CARCINOGENICITY).
IRIS,  EPA'S  INTEGRATED RISK  INFORMATION  SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER  SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                                        3-16

-------
                                                      HEAST  TABLE 3:  CARCINOGENICITY
                                                                                                                               January 1992
CHEMICAL ROUTE
                  EXPERIMENT LENGTH
                       SPECIES    TARGET
                                                       CANCER
                                                                                  [SLOPE FACTOR]
                                                                       [EPA     ORAL     INHALATION
                                                                      GROUP]  (mg/kg/day)-'(tng/kg/day)-
                                                  [UNIT RISK]
                                                 ORAL   INHALATION  REFERENCE
                                                (ug/L)-1 (ug/cu m) '
ETHYL  ACRYLATE                 000140-88-5
        ORAL: GAVAGE     104 WEEKS
                        RAT         FORESTOMACH          TUMORS

        [EPA Group] Comment:  UNDER REVIEW, NUMBER SUBJECT TO CHANGE.

ETHYLENE CHLORIDE   (See  DICHLOROETHANE,  1,2-)

ETHYLENE DIBROMIDE  (See  DIBROMOETHANE,1,2-)

                                   000075-21-8
                                                                       B2
ETHYLENE OXIDE
        INHALATION:      2 YEARS
        INTERMITTENT     RAT
                                                                       B1
                                   BLOOD
                                   BRAIN
LEUKEMIA
GLIOMA
        Inhalation [Unit  Risk] Comment:  UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
        ORAL: GAVAGE
                        LIFETIME,
                        TWICE
                        WEEKLY
                        RAT
                81
                                   STOMACH              TUMORS

        Oral  [Slope]  Comment:  UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
ETHYLENE  THIOUREA             000096-45-7
        ORAL: DIET       2 YEARS
                        MOUSE       LIVER
                                                                       B2
                                                       TUMORS
                        4.8E-2
                         1.4E-6
                 010118
                                   3.5E-1
                                   1E-4    010422
1.02E+0
2.9E-5
                                                                                                                         010421
                        6E-1
                         1.7E-5
                 010423
        Oral  [Slope]  Comment:  UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
        General Comment:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ETHYLNITROSOUREA
                                   000759-73-9
                                                                       B2
                                                                                                                         010426
        [EPA Group] Comment:  THE CRAVE WORK GROUP VERIFIED A B2 CANCER CLASSIFICATION
        General Comment:   FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 OR (202) 260-4761)  FOR RCRA-APPROVED NUMERIC
                         ASSESSMENT OF THIS COMPOUND.  UNDER REVIEW.
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED  MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT:   (513) 569-7254, FTS 684-7254.
                                                                                                                                      3-17

-------
                                                       HEAST  TABLE  3: CARCINOGENICITY
                                                                                                                                  January 1992
CHEMICAL  ROUTE
                  EXPERIMENT LENGTH
                        SPECIES     TARGET
                                CANCER
            [SLOPE FACTOR]
 [EPA      ORAL     INHALATION
GROUP]  (mg/kg/dayr'dng/kg/dayr1
                           [UNIT RISK]
                         ORAL   INHALATION  REFERENCE
                         (ug/L)-' (ug/cu m)'1
FOLPET
FORMALDEHYDE
        INHALATION
                                   000133-07-3
                                                                         IRIS    IRIS                      IRIS

        General Comment:  ALSO  SEE KEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

                                   000050-00-0

                                   NASAL CAVITY          TUMORS
24 MONTHS
RAT
 IRIS
           4.5E-2
        Inhalation [Slope]  Comment:
        General Comment:   ALSO SEE
                                   SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
                                 HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
FURAZOLIDONE
        ORAL: DIET
FURIUM
                                   000067-45-8

                                   MAMMARY               TUMORS

        General Comment:   FORMERLY LISTED UNDER NITROFURANS

                                   000531-82-8

                                   BLOOD                LEUKEMIA

                                 LISTED UNDER NITROFURANS

                                   000765-34-4
        ORAL: DIET
45 WEEKS
RAT
28 WEEKS
MOUSE
 B2
3.8E+0
1E-4
                                                                         B2
         5.0E+1
                         1.4E-3
        General Comment:  FORMERLY

GLYCIDALDEHYDE
                                                                         IRIS
        General Comment:   ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

                                   000076-44-8

                                   LIVER                CARCINOMA
HEPTACHLOR
        ORAL: DIET
                                                                         IRIS    IRIS
                                                                   4.5E+0
                                                                                                          IRIS
                        MOUSE
                                                                                                                           010120
          IRIS    010121
        Inhalation  [Slope]  Comment:
        General Comment:  ALSO  SEE
                                   BASED ON  ROUTE TO ROUTE EXTRAPOLATION.  SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
                                 HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
005106
                  005108
                                                                                                                           010122
                                            IRIS    005820
IRIS,  EPA'S  INTEGRATED RISK  INFORMATION  SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                         3-18

-------
                                                       HEAST TABLE 3:  CARCINOGENICITY
                                                                                                                         January 1992
CHEMICAL  ROUTE
          EXPERIMENT LENGTH
               SPECIES     TARGET
CANCER
            [SLOPE FACTOR]
 [EPA      ORAL     INHALATION
GROUP]  (mg/kg/day)-'(mg/kg/day)-
  [UNIT RISK]
 ORAL   INHALATION  REFERENCE
(ug/L)-1 (ug/cu m)'1
HEPTACHLOR  EPOXIDE
        ORAL:  DIET       18-24
                        MONTHS
                        HOUSE
                           001024-57-3
                                   LIVER
                                                                 IRIS
                                                                         IRIS
                                                                                    9.1E+0
                                                                                                  IRIS
                                                             IRIS    010424
                                                        CARCINOMA
        Inhalation  [Slope]  Comment:  BASED ON  ROUTE TO ROUTE  EXTRAPOLATION.  SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        General Conment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC  AND CHRONIC TOXIC1TY (OTHER THAN CARCINOGEN I CITY).
HEXACHLOROBENZENE
        ORAL: DIET       2 YEARS
                        RAT
                           000118-74-1

                           LIVER
                 IRIS
                         IRIS
                                    1.6E+0
                                                  IRIS
                                            IRIS    010365
                                                        TUMORS
        Inhalation  [Slope]  Comment:  BASED ON  ROUTE TO ROUTE EXTRAPOLATION.  SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
          General Comment:   ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENIC!TY>.
HEXACHLOROBUTADIENE
        ORAL:  DIET       22-24
                        MONTHS
                        RAT
                           000087-68-3
                           KIDNEY
                                                                 IRIS
                         IRIS
                                                                                   7.8E-2
                                                                                                 IRIS
                                                            IRIS    005088
TUMORS
        Inhalation  [Slope]  Comment:  BASED ON  ROUTE TO ROUTE EXTRAPOLATION.  SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        General  Comnent:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
HEXACHLOROCYCLOHEXANE-TECHNICAL
        ORAL:  DIET       6-20
                        MONTHS
                        MOUSE       LIVER
                                          000608-73-1
                                                                 IRIS    IRIS        1.8E+0         IRIS       IRIS

                                                TUMORS

Inhalation  [Slope]  Comment:  BASED ON  ROUTE TO ROUTE  EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.

                                          000319-84-6
                                                                 IRIS    IRIS        6.3E+0         IRIS
                                                TUMORS

Inhalation  [Slope]  Conment:   BASED ON ROUTE TO ROUTE EXTRAPOLATION.  SEE APPENDIX  A-II, DOSE CONVERSIONS ON HEAST.
                                                                   010127
HEXACHLOROCYCLOHEXANE,  ALPHA-
        ORAL:  DIET       24 WEEKS
                        MOUSE       LIVER
                                                            IRIS   010123
IRIS, EPA'S INTEGRATED RISK  INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                3-19

-------
                                                      HEAST TABLE 3:  CARCINOGENICITY
                                                                                                                               January 1992
CHEMICAL ROUTE
                  EXPERIMENT LEHGTH
                       SPECIES     TARGET
CANCER
            [SLOPE FACTOR]
 [EPA     ORAL     INHALATION
GROUP] (mg/kg/day)-'
-------
                                                      HEAST  TABLE 3: CARCINOGEN1CITY
                                                                                                                       January 1992
CHEMICAL ROUTE
          EXPERIMENT LENGTH
               SPECIES    TARGET
                                                       CANCER
            [SLOPE FACTOR]
 [EPA     ORAL     INHALATION
GROUP] (mg/kg/dayX'dng/kg/day)-
               [UNIT RISK]
              ORAL   INHALATION  REFERENCE
             (ug/L)-1 (ug/cu •)-'
HYDRAZINE
        ORAL
                           000302-01-2
        INHALATION:
        INTERMITTENT
                1 YEAR

                RAT         NASAL CAVITY         TUMORS

Inhalation [Slope] Comment:   SEE APPENDIX A-I1, DOSE CONVERSIONS ON HEAST.

                           010034-93-2
 IRIS    IRIS

 IRIS
                                                                                          1.7E+1
HYDRAZINE  SULFATE
        ORAL

        INHALATION:
        INTERMITTENT
                1 YEAR
                RAT
 IRIS    IRIS

 IRIS
1.7E+1
                                   NASAL CAVITY
                                                       TUMORS
        Inhalation [Slope] Comment:   SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        General Comment:  LISTED AS  "HYDRAZINE" ON IRIS.
INDENO[1,2,3-CD]PYRENE       000193-39-5
                                                                        IRIS
                                                                                                        IRIS
                               010129

                        IRIS    010128
                                                                                                IRIS
       010131

IRIS    010130
                                                                                                                 010192
        General Comment:   FOR RCRA ACTIVITIES ONLY, CONTACT THE  HEALTH ASSESSMENT SECTION  (FTS 260-4761 OR (202)  260-4761) FOR  RCRA APPROVED NUMERIC
                         ASSESSMENT OF THIS COMPOUND.
ISOPHORONE
                           000078-59-1
                                                                        IRIS    IRIS                      IRIS

        General Comment:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

LEAD                              007439-92-1
                                                                        IRIS

        General Comment:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

LINDANE  (See  HEXACHLOROCYCLOHEXANE,  GAMMA-)
                                                                                                                         005094
                                                                                                                 005096
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER  INFORMATION: IRIS USER  SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                               3-21

-------
                                                    HEAST TABLE 3: CARCINOGENICITY
                                                                                                          January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
     SPECIES     TARGET
                                                     CANCER
           [SLOPE FACTOR]
 [EPA     ORAL    INHALATION
GROUP] 
-------
                                                      HEAST TABLE 3:  CARCIN06ENICITY
                                                                                                                              January 1992
CHEMICAL ROUTE
                  EXPERIMENT LENGTH
                       SPECIES     TARGET
                                                      CANCER
                                               [SLOPE FACTOR]          [UNIT RISK]
                                    [EPA      ORAL     INHALATION      ORAL   INHALATION  REFERENCE
                                   GROUP]  (mg/kg/day) '(tng/kg/day)-1    (ug/L) ' (ug/cu m)-1
METHYLENE  CHLORIDE
        INHALATION
                                   000075-09-2
                                                                       IRIS

        ORAL                                                        .    IRIS    IRIS                     IRIS

        General Comment:  ALSO SEE  HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGEN I CITY).
METHYLENE-BIS(N.N-DIMETHYL)  ANILINE, 4,4'-
                                                                  000101-61-1
                                                                       IRIS    IRIS
                                                                                                       IRIS
        General Comment:  ALSO SEE  HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGEN I CITY).
METHYLENE-BIS(2-CHLOROANILINE),  4,4'-    000101-14-4
        ORAL: DIET      2 YEARS                                         B2
                       RAT        LUNG                TUMORS
                                                                              1.3E-1
                                                       1.3E-1
        Inhalation [Slope] Comment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.

                                                000101-77-9

                                                      TUMORS

METHYLNITROSOUREA            000684-93-5
METHYLENEBISBENZENAMINE,  4,4'-
        ORAL: DRINKING   2 YEARS
        WATER           RAT        LIVER
                                            2.5E-1
                                7.1E-6
                                                                       B2
                                                                                                                 IRIS    005904

                                                                                                                        005100
                                                                                                                        010137
                                3.7E-6     3.7E-5  010425
                                          010136
                                                                                                                        010427
        [EPA Group]  Comment:  UNDER REVIEW.  THE CRAVE WORK GROUP VERIFIED A B2 CANCER CLASSIFICATION.
        General Comment:  FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 OR (202)  260-4761) FOR RCRA-APPROVED NUMERIC
                        ASSESSMENT  FOR THIS COMPOUND.
MIREX
        ORAL: DIET
                       2 YEARS
                       RAT
002385-85-5

LIVER
ADRENAL
62
1.8E+0
5.1E-5
                                                                                                                        005102
                                                       TUMORS
                                                       TUMORS
        [EPA Group]  Comment:  UNDER  REVIEW, NUMBER SUBJECT  TO CHANGE.
        General Comment:  ALSO SEE HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION:  IRIS USER SUPPORT:   (513) 569-7254, FTS 684-7254.
                                                                                                                                     3-23

-------
                                                       HEAST TABLE 3:  CARCINOGENICITY
                                                                                                              January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
     SPECIES    TARGET
                                                       CANCER
                                                [SLOPE FACTOR]
                                     [EPA      ORAL     INHALATION
                                    GROUP]  (mg/kg/day)-'(mg/kg/day)
                          [UNIT RISK]
                         ORAL   INHALATION  REFERENCE
                        (ug/L)-1 (ug/cu m)'1
NIAGARA BLUE  4B
                 002429-74-5
                                                                        B2                                                010141

        [EPA Group] Comment:  BASED ON  THE  FACT THAT 3,3-DIMETHOXYBENZIDENE, A KNOWN  EPA GROUP B2 CARCINOGEN,  IS A METABOLITE OF NIAGARA BLUE  4B.
NICKEL REFINERY  DUST
        INHALATION:
        OCCUPATIONAL     HUMAN
                                                      IRIS
                                                                         8.4E-1
                                                                                IRIS    005103
                                   RESPIRATORY SYSTEM   TUMORS
        Inhalation [Slope]  Comment:  SEE APPENDIX A-II,  DOSE CONVERSIONS ON HEAST.
        General Comment:   FORMERLY LISTED AS NICKEL. ALSO  SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC  TOXICITY (UNDER NICKEL).
NICKEL SUBSULFIDE
        INHALATION:
        OCCUPATIONAL
                        HUMAN
                 012035-72-2
                 RESPIRATORY SYSTEM
                                                      IRIS
                                                        1.7E+0
                                   IRIS    005768
                                                        TUMORS
        Inhalation [Slope]  Comment:  SEE APPENDIX A-II,  DOSE CONVERSIONS ON HEAST.
        General Comment:   FORMERLY LISTED AS NICKEL.  ALSO  SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (UNDER NICKEL).
NITROFURAZONE
        ORAL: DIET
      46 WEEKS
      RAT
NITROPROPANE,  2-
        INHALATION:      22 MONTHS
        INTERMITTENT     RAT         LIVER
000059-87-0

MAMMARY

000079-46-9
1.5E+0
                                                       TUMORS
                                     TUMORS
NITROSO-DI-N-BUTYLAMINE, N-    000924-16-3
        ORAL: DRINKING   LIFETIME
        WATER            MOUSE       BLADDER               TUMORS
                                   ESOPHAGUS             TUMORS
B2
                                                      B2
                                                      IRIS    IRIS
A.3E-5
                                                        9.4E+0
                                                                         5.4E+0
                                                                                       IRIS
005110
                                   2.7E-3  010142
                                                                                IRIS    010143
        Inhalation  [Slope]  Comment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE  CONVERSIONS ON  HEAST.
IRIS,  EPA'S INTEGRATED  RISK INFORMATION SYSTEM, IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT:   (513) 569-7254,  FTS 684-7254.
                                                                                                                      3-24

-------
                                                    HEAST TABLE 3:  CARCINOGENICITY
                                                                                                                         January 1992
CHEMICAL ROUTE
                 EXPERIMENT LENGTH
                      SPECIES     TARGET
                                                    CANCER
NITROSO-DI-N-PROPYLAMINE,  N-   000621-64-7

NITROSODIETHANOLAMINE, N-       001116-54-7

                                     000055-18-5
           [SLOPE FACTOR]
 [EPA     ORAL     INHALATION
GROUP] (mg/kg/day)-'(mg/kg/d8y)-
                                                                    IRIS   IRIS
                                                                    IRIS   IRIS
  [UNIT RISK]
 ORAL   INHALATION REFERENCE
(ug/L) ' (ug/cu m)-'
                                                                                                   IRIS
                                                                                                   IRIS
NITROSODIETHYLAMINE,  N-
       ORAL:  DRINKING  6 OR 12
       WATER           MONTHS
                      RAT
NITROSODIMETHYLAMINE,  N-    000062-75-9
       ORAL: DRINKING
       WATER          RAT        LIVER
                                                                    IRIS    IRIS
                                                                                      5.1E+1
                                                                                                   IRIS
                                                    TUMORS

        Inhalation [Slope] Comment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-1I, DOSE CONVERSIONS ON HEAST.

NITROSODIPHENYLAMINE,  N-    000086-30-6
NITROSOMETHYLETHYLAMINE,  N-   010595-95-6
NITROSOMETHYLVINYLAMINE,  N-   004549-40-0
       ORAL:  DRINKING  RAT        UPPER               CARCINOMAS
       WATER                      DIGESTIVE
                                 TRACT
                                                                    IRIS    IRIS
                                                                    IRIS    IRIS
                                                                    82
                                                                                                   IRIS
                                                                                                   IRIS
        INHALATION
                      RAT
                                 UPPER
                                 RESPIRATORY
                                 TRACT
                                                    CARCINOMAS
                                                                                                                    010147
                                                                                                                    010144
                                                                    IRIS   IRIS       1.5E+2        IRIS       IRIS    010145

                                 LIVER               TUMORS

        Inhalation [Slope] Comment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON  HEAST.
                                          IRIS   010146
                                                005112
                                                                                                                    010148
                                                010149
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                3-25

-------
                                                     HEAST TABLE  3:  CARCINOGENICITY
                                                                                                            January 1992
CHENICAL ROUTE
EXPERIMENT LENGTH
     SPECIES    TARGET
                                                      CANCER
            [SLOPE FACTOR]
 [EPA     ORAL     INHALATION
GROUP] (mg/kg/day)-'(mg/kg/day)
  [UNIT RISK]
 ORAL   INHALATION  REFERENCE
(ug/L)-1 (ug/cu or1
NITROSOPYRROLIDINE, N-         000930-55-2
        ORAL: DIET      LIFETIME
                       RAT         LIVER               TUMORS
                                                     IRIS    IRIS
                   2.1E+0
                                                                                     IRIS
           IRIS    010300
        Inhalation [Slope] Comment: BASED ON  ROUTE TO ROUTE EXTRAPOLATION. SEE  APPENDIX A-II, DOSE CONVERSIONS ON  HEAST.

PARATHION                       000056-38-2
                                                                       IRIS

        General Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                                      005116
PCBs  (See  POLYCHLORINATED BIPHENYLS)

PENTABROMO-6-CHLORO-CYCLOHEXANE,  1,2,3,4,5-      000087-84-3
        ORAL: DIET
     2 YEARS
     RAT
        2.3E-2
                                                                                                       6.6E-7
                                  INTESTINE, LARGE     TUMORS

        Oral [Slope] Comment:   BASED ON RESULTS WITH THE ALPHA ISOMER.
PENTACHLORONITROBENZENE     000082-68-8
        ORAL            72 WEEKS
                       MOUSE      LIVER
                                                            2.6E-1
                                 7.4E-6
                                                      TUMORS
        Oral  [Slope]  Comment:  UNDER REVIEW,  NUMBER SUBJECT TO CHANGE.
        General Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
PENTACHLOROPHENOL
                 000087-86-5
                                                                       IRIS    IRIS
                                                                                                       IRIS
                  010150
                  010151
                                                                                                      010381
        General Comment:  TECHNICAL GRADE PENTACHLOROPHENOL AND DOWCIDE EC-7 WERE TESTED.  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY
        (OTHER THAN CARCINOGENICITY).
PHENYLENEDIAMINE,  0-         000095-54-5
        ORAL: DIET      548 DAYS
                       RAT        LIVER
                                                     B2
        4.7E-2
 1.3E-6
010152
                                     TUMORS
        Oral  [Slope]  Comment:  BASED ON LIVER  TUMORS IN  RATS TREATED WITH 0-PHENYLENEDIAMINE DIHYDROCHLORIDE.
        General Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY  (OTHER THAN CARCINOGENICITY).
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                    3-26

-------
                                                     HEAST TABLE 3: CARCINOGENICITY
                                                                                                            January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
     SPECIES    TARGET
                                                      CANCER
                                               [SLOPE FACTOR]
                                    [EPA     ORAL     INHALATION
                                   GROUP]  (mg/kg/dayr'dng/kg/day)'
                          [UNIT RISK]
                        ORAL   INHALATION  REFERENCE
                        (ug/L)-1 (ug/cu o)-1
PHENYLPHENOL,  2-              000090-43-7
        ORAL: DIET      637 DAYS
                       RAT        URINARY BLADDER

POLYBROMINATED BIPHENYLS
        ORAL: GAVAGE     25 WEEKS
                       RAT        LIVER
                                  LIVER
                                     TUMORS
                                                     B2
                                                            1.94E-3
                                            8.9E+0
                                    CARCINOMA
                                    NEOPLASTIC NODULE
POLYCHLORINATED BIPHENYLS  (PCBs)        001336-36-3


PROPYLENE  OXIDE               000075-56-9
        ORAL
        INHALATION:      2 YEARS
        INTERMITTENT     MOUSE      NASAL  CAVITY
                                                     IRIS    IRIS


                                                     IRIS    IRIS

                                                     IRIS
                                                       1.3E-2
                                                      TUMORS
                                                                    5.5E-8
                        2.5E-4
                                                                                     IRIS
                                                                    IRIS
        Inhalation [Slope] Comnent:  SEE APPENDIX A-II, DOSE CONVERSIONS ON  HEAST.
        General Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
QUINOLINE
        ORAL: DIET
RDX (CYCLONITE)
     20-40
     WEEKS
     RAT
000091-22-5

LIVER

000121-82-4
1.2E+1
3.5E-4
                                                      TUMORS
                                                                       IRIS    IRIS                      IRIS

        General Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

SELENIUM  SULFIDE              007446-34-6
                                                                       IRIS

        Oral  [Slope]  Comment:   STUDY RESULTS WERE CONSIDERED INCONCLUSIVE FOR QUANTITATIVE RISK ASSESSMENT.
                 010153



                 010154




                 005118


                 010156

          IRIS   010155
010158
                                                                                                                        010157
                                                                                                      010194
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER  INFORMATION: IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                   3-27

-------
                                                       HEAST TABLE 3:  CARCINOGENICITY
                                                                                                                January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
     SPECIES     TARGET
                                                CANCER
            [SLOPE FACTOR]
 [EPA      ORAL     INHALATION
GROUP]  (ng/kg/dayr'dng/kg/day)-1
                           [UNIT RISK]
                         ORAL   INHALATION  REFERENCE
                         (ug/L)-1 (ug/cu n>r'
SIMAZINE
        ORAL:  DIET
      2  YEARS
      RAT
                            000122-34-9

                            MAMMARY
         1.2E-1
                         3.4E-6
                                010195
                                                        CARCINOMA
        Oral  [Slope] Comment:  UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
        General  Comment:  ALSO SEE  HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY (OTHER  THAN CARCINOGENICITY).
SODIUM DIETHYLDITHIOCARBAMATE
        ORAL:  DIET       77 WEEKS
                        MOUSE      LIVER
                                                              2.7E-1
                                          000148-18-5
                                                                 c
                                                TUMORS

General  Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                                  7.7E-6
                                           005126
STYRENE
                 000100-42-5
        General Comment:  CONTACT  THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300; FTS 684-7300.
                         ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY (OTHER THAN CARCINOGENICITY).
TCDD,  2,3,7,8-
        ORAL:  DIET
      720 DAYS
      RAT
                            001746-01-6

                            RESPIRATORY           TUMORS
                            SYSTEM
                            LIVER                 TUMORS
 B2
1.5E+5
1.5E+5
4.5E+0
                                                                                                          009994
 3.3E-5  005128
(pg/cu m)'1
        Oral  [Slope] Comment:  UNDER REVIEW, NUMBER  SUBJECT TO CHANGE.
        Inhalation  [Unit Risk]  Comment:  UNDER REVIEW,  NUMBER SUBJECT TO  CHANGE. BASES  ON ROUTE TO ROUTE EXTRAPOLATION.  AN ABSORPTION FACTOR OF 75%
                                       IS USED TO  CALCULATE THE UNIT  RISK FROM THE SLOPE FACTOR.
        EPA Comment:  B2 CLASSIFICATION IS FOR TCDD  ALONE. MIXTURES OF  PHENOXY HERBICIDES AND/OR CHLOROPHENOLS WITH 2,3,7,8-TCDD AS A CONTAMINANT
                     ARE CLASSIFIED AS B1 CARCINOGENS.
TETRACHLOROETHANE,  1,1,1,2-      000630-20-6
        ORAL:  GAVAGE     103 WEEKS
                        MOUSE      LIVER                TUMORS
                                                       IRIS
                                                                         IRIS
                    2.6E-2
                          IRIS
                         IRIS    010302
        Inhalation  [Slope] Comment:  BASED ON ROUTE  TO  ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
IRIS,  EPA'S  INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED MONTHLY.  FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                        3-28

-------
                                                     HEAST TABLE 3:  CARCINOGENICITY
                                                                                                                           January 1992
CHEMICAL ROUTE
                 EXPERIMENT LENGTH
                       SPECIES
                                 TARGET
                                                     CANCER
           [SLOPE FACTOR]
 [EPA     ORAL    INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)
  [UNIT RISK]
 ORAL   INHALATION  REFERENCE
(ug/L)' (ug/cu m)"'
                                                                      IRIS
                                                                             IRIS
                                                                                       2.0E-1
                                                                                                     IRIS
TETRACHLOROETHANE,  1,1,2,2-     000079-34-5
       ORAL: GAVAGE     75  WEEKS
                       MOUSE       LIVER               CARCINOMA

       Inhalation [Slope] Comment:   BASED ON ROUTE TO ROUTE EXTRAPOLATION.  SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.

TETRACHLOROETHYLENE           000127-18-4
       (PERCHLOROETHYLENE)

       General Comment: CONTACT THE SUPERFUND  HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300; FTS 684-7300.
                       ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TETRACHLOROTOLUENE,  P,  a,a,a-
       ORAL: GAVAGE     17.5 WEEKS
                       MOUSE       ADENOCARC1NOMA

TETRACHLORVINPHOS  (STIROPHOS)
       ORAL: DIET       560 DAYS
                       MOUSE       LIVER
                                                 005216-25-1

                                                     TUMORS

                                               000961-11-5

                                                     TUMORS
                                                                     B2
        2.0E+1
                                                                             2.4E-2
 5.7E-4
                                6.9E-7
        [EPA Group] Comment:  UNDER REVIEW, CLASSIFICATION SUBJECT  TO CHANGE.
        General Comment:  ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TOLUENE-2,4-DIAMINE
        ORAL: DIET       84-103
                       WEEKS
                       RAT
                                  000095-80-7
                                                                     B2
                                                                             3.2E+0
                                9.1E-5
                                  MAMMARY

TOLUIDINE,  0-  (See  METHYLANILINE,2-)

                                  000106-49-0
                       18 MONTHS
                       MOUSE       LIVER
                                                     TUMORS
TOLUIDINE,  P-
       ORAL: DIET
                                                                             1.9E-1
                                5.4E-6
                                                                                                              IRIS   005130
                                                                                                                      009995
005028
                  010159
                  010160
                  010162
                                                     TUMORS
IRIS, EPA'S INTEGRATED RISK  INFORMATION SYSTEM,  IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT:  (513) 569-7254, FTS 684-7254.
                                                                                                                                   3-29

-------
                                                      HEAST TABLE 3:  CARCINOGENICITY
                                                                                                             January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
     SPECIES    TARGET
                                                      CANCER
                                               [SLOPE FACTOR]
                                    [EPA     ORAL    INHALATION
                                    GROUP] (mg/kg/dayr'dng/kg/day)-1
                                 (UNIT RISK]
                                ORAL   INHALATION REFERENCE
                               (ug/L)"1 (ug/cu n)~'
TOXAPHENE
        ORAL: DIET
      18 MONTHS
      MOUSE
008001-35-2

LIVER
IRIS
IRIS
1.1E+0
                                                       TUMORS
        Inhalation [Slope] Comment:  SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        Inhalation [Unit Risk] Comment:  BASED ON ROUTE TO ROUTE EXTRAPOLATION.
TRICHLOROANILINE,  2,4,6-     000634-93-5
        ORAL: DIET      18 MONTHS
                       MOUSE       VASCULAR SYSTEM
                                     TUMORS
TRICHLOROANILINE  HYDROCHLORIDE,  2,4,6-  033663-50-2
        ORAL: DIET       18 MONTHS
                      .  MOUSE      VASCULAR SYSTEM       TUMORS
TRICHLOROETHANE,  1,1,2-      000079-00-5
        ORAL: GAVAGE    78 WEEKS
                       MOUSE       LIVER
                                                      IRIS
                                                             3.4E-2
                                                             2.9E-2
                                                             IRIS
                                                       5.7E-2
                                                       CARCINOMA
IRIS
IRIS    005134
                                                                     1E-6
                                                                     8.2E-7
                                                                                      IRIS
                                                 0011.11
                                                 005142
                                          IRIS   005144
        Inhalation [Slope] Comment:   BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        General Comment:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

TRICHLOROETHYLENE             000079-01-6

        General Comment:  CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER:  (513) 569-7300; FTS 684-7300.
TRICHLOROPHENOL,  2,4,6-      000088-06-2
        ORAL: DIET       107 WEEKS
                        MOUSE       BLOOD
                                                      IRIS
                                                             IRIS
                                                                        1E-2
                                                                                      IRIS
                                                                                                       009996
                                                                               IRIS   010428
                                                       LEUKEMIA
        Inhalation [Slope] Comment:   BASED ON ROUTE TO ROUTE  EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
        General Comment:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TRIFLURALIN
                 001582-09-8
                                                                        IRIS    IRIS                      IRIS

        General Comment:  ALSO SEE HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
                                                                                                                         010163
IRIS,  EPA'S INTEGRATED RISK INFORMATION SYSTEM,  IS UPDATED  MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT:   (513) 569-7254, FTS 684-7254.
                                                                                                                     3-30

-------
                                                        HEAST TABLE 3:  CARCINOGENICITY
                                                                                                                                    January 1992
CHEMICAL ROUTE
                   EXPERIMENT LENGTH
                        SPECIES     TARGET
CANCER
            [SLOPE  FACTOR]
 [EPA      ORAL     INHALATION
GROUP]  (mg/kg/dayr'dng/kg/day)-
  [UHIT RlSd
 ORAL   INHALATION  REFERENCE
(ug/L)-1  (ug/cu m)'1
TRIMETHYL  PHOSPHATE
        ORAL: GAVAGE      103 WEEKS
                         MOUSE
                                    000512-56-1
                                    UTERUS
                                                                          B2
                         3.7E-2
                                   1.1E-6
TUMORS
TRINITROTOLUENE,2,4,6  (TNT)    000118-96-7
                                                                          IRIS    IRIS                      IRIS

        General  Comment:  ALSO SEE HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).

VINYL  BROMIDE  (See BROMOETHENE)

                                    000075-01-4
                   010164
                                                                                                                              009990
VINYL  CHLORIDE
        ORAL: DIET
                        1001 DAYS
                        RAT         LUNG
                                    LIVER
                         1.9E+0
                                   5.4E-5
                                                         TUMORS
                                                         TUMORS
        Oral [Slope]  Comment:  UNDER REVIEW,  NUMBER SUBJECT TO CHANGE.

                        1 YEAR

                        RAT
        INHALATION:
        INTERMITTENT
                                                                                             3.0E-1
                   010368
                                                             8.4E-5  010367
                                    LIVER
                                                         TUMORS
        Inhalation [Unit Risk] Comment:   UNDER  REVIEW, NUMBER SUBJECT  TO CHANGE.
        General  Comment:  THE MOST RECENTLY REVIEWED QUANTITATIVE TOXICITY VALUES LISTED HERE APPEAR IN EPA DOCUMENTS PUBLISHED IN 1984 AND 1985.
        USE OF THESE VALUES ON AN INTERIM BASIS WAS VALIDATED BY CRAVE (04/05/90).  THE AGENCY  IS AWARE THAT THESE VALUES DO NOT INCORPORATE
        CONSIDERABLE INFORMATION THAT IS NOW AVAILABLE.  THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT'S POSITION IS THAT THESE TOXICITY VALUES
        DO NOT REFLECT STATE-OF-THE-ART  SCIENCE FOR VINYL CHLORIDE.  EPA NOW HAS INDIVIDUAL  ANIMAL DATA, NOT AVAILABLE WHEN THE ORAL UNIT RISK WAS
        CALCULATED, THAT MAY  INFLUENCE THIS VALUE.  ADDITIONAL INFORMATION THAT MAY BE FACTORED INTO A REVISED  QUANTITATIVE TOXICITY VALUE INCLUDES
        DATA ON  INCREASED SENSITIVITY OBSERVED  IN YOUNG ANIMALS AND  DATA ON METABOLISH/PHARMACOKINETICS.  A UNIT  RISK FOR AIR THAT CONSIDERS
        INFORMATION ON YOUNG AGE EXPOSURE INCREASES THE RISK (I.E.,  LOWERS THE RISK SPECIFIC DOSE) BY AT LEAST  3-FOLD.  THE CONSIDERATION OF
        METABOLISM PHARMACOKINETICS WILL FURTHER INCREASE THE RISK.  ONE UNPUBLISHED PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL PREDICTION RESULTS
        IN A 100-FOLD  INCREASED RISK.
IRIS,  EPA'S INTEGRATED RISK INFORMATION  SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION:  IRIS USER SUPPORT:  (513) 569-7254,  FTS 684-7254.
                                                                                                                                            3-31

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                         Table 4A:  Radionuclide  Carcinogenicity --  Slope  Factors'
                                                     (In  Units  of Picocuries")
                                                                                                                                 JANUARY 1992
Element
(Atomic Number) Isotope6
Actinium (89) Ac-225'
Ac-227t
Ac-227+D
Ac-228f
Americium (95) Am-241*
Am-242
Am-242m
Am-243f
Am-243+D
Antimony (51) Sb-122
Sb-124
Sb-125
Sb-126
Sb-126m
CASRN"
014265-85-1
014952-40-0
014952-40-0(4-0)
014331-83-0
014596-10-2
013981-54-9
013981-54-9(m)
014993-75-0
014993-75-0(+D)
014374-79-9
014683-10-4
014234-35-6
015756-32-8
015756-32-8(m)
Radioactive
Half-life8
1.000E+01
2.180E+01
2.180E+01
6.130E+00
4.320E+02
1.600E+01
1.520E+02
7.380E+03
7.380Et03
2.700E+00
6.020E+01
2.770E-I-00
1.240E+01
1.900E+01
D
Y
Y
H
Y
H
Y
Y
Y
D
D
Y
0
M
ICRP
Lung
Class1
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
G!
Absorption
Factor (f,)9
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.7E-11
2.8E-10
3.5E-10
5.0E-13
2.4E-10
3.6E-13
2.3E-10
2.4E-10
2.4E-10
2.0E-12
2.9E-12
8.4E-13
2.8E-12
7.2E-14
Inhalation
(Risk/pCi)
2.4E-09
8.0E-08
8.8E-08
2.6E-11
3.2E-08
1.2E-11
2.8E-08
3.2E-08
3.2E-08
3.4E-12
2.2E-1 1
1.1E-11
8.8E-12
2.6E-14
External Exposure
(Risk/yr per pCi/g soil)
7.6E-09
2.6E-1 1
8.5E-07
2.9E-06
4.9E-09
5.8E-09
1.2E-10
2.4E-08
2.5E-07
1.4E-06
6.5E-06
1.2E-06
9.1E-06
5.1E-06
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10" Ci.
c For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a *f are members of a decay chain.
" Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second,  M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by  the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the User's Guide for instructions.
                                                                                                                                             4A-1

-------
                        Table  4A:  Radionuclide  Carcinogenicity  -- Slope  Factors'
                                                    (In  Units  of Picocuries5)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)

Argon (18)
Astatine (85)
Barium (56)





Beryllium (4)
Bismuth (83)


Isotope*
Sb-127
Sb-129
Ar-41
At-217f
Ba-131
Ba-133
Ba-133m
Ba-137mt
Ba-139
Ba-140
Be-7
Bi-206
Bi-207
Bi-210f
CASRNd
013968-50-8
014331-88-5
014163-25-8
017239-90-6
014914-75-1
013981-41-4
013981-41-4(m)
013981-97-0(m)
014378-25-7
014798-08-4
013966-02-4
015776-19-9
013982-38-2
014331-79-4
Radioactive
Half-life6
3.850E+00
4.400E+00
1.830E+00
3.230E-02
1.180E+01
1.050E+01
3.890E-I-01
2.550E-fOO
8.310E+01
1.280E+01
5.340E+01
6.240E+00
3.340E+01
5.010E+00
D
H
H
S
D
Y
H
M
M
D
D
D
Y
D
ICRP
Lung
Class'
W
W
*
D
0
D
D
D
D
D
Y
W
W
W
Gl
Absorption
Factor (f,)fl
1.0E-01
1.0E-01
1.0E+00
1.0E+00
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
5.0E-03
5.0E-02
5.0E-02
5.0E-02
Ingestion
(Risk/pCi)
2.0E-12
5.9E-13
4.5E-18
4.8E-13
1.2E-12
6.2E-13
2.4E-15
2.1E-13
2.7E-12
3.0E-14
2.2E-12
1.4E-12
1.6E-12
Inhalation
(Risk/pCi)
4.1E-12
5.1E-13
5.8E-16
5.6E-17
3.6E-13
3.6E-12
3.5E-13
6.0E-16
1.5E-13
2.0E-12
2.7E-13
4.3E-12
1.8E-11
8.0E-1 1
External Exposure
(Risk/yr per pCi/g soil)
2.1E-06
4.9E-06
4.4E-06
7.7E-10
1.2E-06
8.4E-07
9.5E-08
2.0E-06
7.7E-08
5.4E-07
1.5E-07
1.1E-05
4.9E-06
O.OE+00
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10'12 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also induded.  Radionudides designated with a T are members of a decay chain.
" Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream.  Lung dassifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the User's Guide for instructions.       4A-2

-------
                        Table 4A: Radionuclide  Carcinogenicity  •- Slope  Factors'
                                                    (In  Units of Picocuriesb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)




Bromine (35)
Cadmium (20)


Calcium (20)

Carbon (6)
Cerium (58)
Isotope0
81-211*
Bi-212f
Bi-213f
Bi-214f
Br-82
Cd-109
Cd-115
Cd-115m
Ca-45
Ca-47
C-11
C-14
C-15
Ce-141
CASRN"
015229-37-5
014913-49-6
015776-20-2
014733-03-0
014666-69-2
014109-32-1
014336-68-6
014336-68-6(01)
013966-05-7
001439-99-2
014333-33-6
014762-75-5
015929-2*4
013967-74-3
Radioactive
Half-life8
2.130E+00
6.055E+01
4.570E+01
1.990E+01
3.530E+01
4.640E+02
5.350E+01
4.460E+01
1.630E+02
4.540E-I-00
2.050E+01
5.730E+03
2.450E+00
3.250E+01
M
M
M
M
H
D
H
D
D
D
M
Y
S
D
ICRP
Lung
Class'
W
W
W
W
D
Y
Y
Y
W
W
D
•
D
Y
Gl
Absorption
Factor (f,)9
5.0E-02
5.0E-02
5.0E-02
5.0E-02
1.0E+00
5.0E-02
5.0E-02
5.0E-02
3.0E-01
3.0E-01
1.0E+00
1.0E+00
1.0E+00
3.0E-04
Ingestion
(Risk/pCi)
1.2E-14
3.1E-13
2.3E-13
1.3E-13
1.1E-12
7.9E-12
1.7E-12
5.2E-12
9.9E-13
2.0E-12
4.9E-14
9.0E-13
8.1E-16
8.3E-13
Inhalation
(Risk/pCi)
1.9E-13
6.6E-12
3.0E-13
2.1E-12
8.7E-13
6.5E-11
2.6E-12
3.9E-1 1
5.1E-12
4.6E-12
2.1E-14
6.4E-15
2.1E-16
8.4E-12
External Exposure
(Risk/yr per pCi/g soil)
1.3E-07
5.9E-07
4.1E-07
5.3E-06
8.9E-06
7.3E-10
6.3E-07
7.5E-08
5.8E-18
3.6E-06
3.2E-06
O.OE+00
1.3E-07
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10"'2 Ci.
0 For each radionuclide listed, corresponding sbpe factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D* to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
9 Radioactive half-lite: S = Second, M = Minute, 0 = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclido.
1 Lung clearance classification recommended by the International Commission on  Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope fadors. See the User's Guide for instructions.       4A-3

-------
                       Table 4A:  Radionuclide  Carcinogenicity - Slope Factors'
                                                    (In  Units  of Picocuriesb)
JANUARY 1992
Element
(Atomic Number)


Cesium (55)







Chlorine (17)

Chromium (24)
Cobalt (27)
Isotope0
Ce-143
Ce-144
Cs-131
Cs-134
Cs-134m
Cs-135
Cs-136
Cs-137t
Cs-137+D
Cs-138
CI-36
CI-38
Cr-51
Co-57
CASRNd
014119-19-8
014762-78-8
014914-76-2
013967-70-9
013967-70-9(m)
015726-30-4
014234-29-8
010045-97-3
010045-97-3(+D)
015758-29-9
013981-43-6
014158-34-0
014392-02-0
013981-50-5
Radioactive
Half-life9
3.300E+01
2.840E+02
9.690E+00
2.060E+00
2.900E+00
2.300E+06
1.320E+01
3.020E+01
3.020E+01
3.220E+01
3.010E+05
3.720E+01
2.770E+01
2.710E+02
H
0
D
Y
H
Y
D
Y
Y
M
Y
M
D
D
ICRP
Lung
Class'
Y
Y
D
D
D
D
D
D
D
D
D
D
Y
Y
Gl
Absorption
Factor (f,)9
3.0E-04
3.0E-04
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E-01
3.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.3E-12
6.1E-12
1.4E-13
4.1E-11
4.1E-14
4.0E-12
6.7E-12
2.8E-11
2.8E-11
1.9E-13
1.8E-12
2.3E-13
4.3E-14
5.8E-13
Inhalation
(Risk/pCi)
2.2E-12
3.4E-10
1.0E-13
2.8E-1 1
3.9E-14
2.7E-12
4.6E-12
1.9E-11
1.9E-11
9.6E-14
1.4E-12
1.3E-13
3.0E-13
8.2E-12
External Exposure
(Risk/yr per pCi/g soil)
6.7E-07
2.5E-08
2.8E-09
5.2E-06
2.0E-08
O.OE+00
7.2E-06
O.OE+00
2.0E-06
8.3E-06
O.OE+00
5.7E-06
9.2E-08
1.9E-07
 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10'1Z Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D* to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+0), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided (or reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the User's Guide for instructions.       4A-4

-------
                        Table  4A:  Radionuclide  Carcinogenicity  - Slope Factors'
                                                     (In  Units  of  Picocuriesb)
JANUARY 1992
Element
(Atomic Number)



Copper (29)
Curium (96)






Dysprosium (66)

Erbium (63)
Isotope6
Co-58
Co-58m
Co-60
Cu-64
Cm-242
Cm-243
Cm-244
Cm-245
Cm-246
Cm-247
Cm-248
Dy-165
Dy-166
Er-169
CASRNd
01381-38-9
01381-38-9(m)
010198-40-0
013981-25-4
015510-73-3
015757-87-6
013981-15-2
015621-76-8
015757-90-1
015758-32-4
015758-33-5
013967-64-1
015840-01-4
015840-13-8
Radioactive
Half-life6
7.080E+01
9.150E+00
5.270E+00
1.270E+01
1.630E+02
2.850E+01
1.810E+01
8.500E-I-03
4.750E+03
1.560E+07
3.390E+05
2.330E+00
8.160E+01
9.400E+00
D
H
Y
H
D
Y
Y
Y
Y
Y
Y
H
H
D
ICRP
Lung
Class'
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f ,)fl
3.0E-01
3.0E-01
3.0E-01
5.0E-01
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
3.0E-04
3.0E-04
3.0E-04
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.6E-12
3.2E-14
1.5E-11
1.7E-13
1.3E-11
1.9E-10
1.6E-10
2.4E-10
2.4E-10
2.2E-10
9.1E-10
1.5E-13
1.9E-12
4.4E-13
Inhalation
(Risk/pCi)
9.8E-12
7.3E-14
1.5E-10
2.0E-13
3.9E-09
2.6E-08
2.2E-08
3.2E-08
3.2E-08
3.0E-08
1.2E-07
1.1E-13
5.0E-12
1.5E-12 .
External Exposure
(Risk/yr per pCi/g soil)
3.3E-06
4.8E-11
8.6E-06
6.0E-07
3.4E-11
1.6E-07
3.0E-1 1
5.3E-08
2.7E-11
9.2E-07
2.2E-1 1
5.7E-08
2.7E-08
8.4E-12
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
" A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10" Ci.
c For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a *+D* to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
" Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
9 Radioactive  half-life: S = Second, M = Minute. D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply  or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.      4A-5

-------
                        Table  4A:  Radionuclide  Carcinogenicity - Slope  Factors'
                                                     (In  Units  of Picocuries")
                                                                                                                                 JANUARY 1992
Element
(Atomic Number)

Europium (63)



Fluorine (9)
Francium (87)

Gadolinium (64)

Gallium (31)

Germanium (32)
Gold (79)
Isotope0
Er-171
Eu-152
Eu-154
Eu-155
Eu-156
F-18
Fr-221'
Fr-223f
Gd-153
Gd-159
Ga-67
Ga-72
Ge-71
Au-196
CASRN"
014391-45-8
014683-23-9
015585-10-1
014391-16-3
014280-35-4
013981-56-1
015756-41-9
015756-98-6
014276-65-4
014041-42-0
014119-09-6
013982-22-4
014374-81-3
014914-16-0
Radioactive
Half-life0
7.520E+00
1.360E+01
8.800E+00
4.960E+00
1.520E+01
1.100E+02
4.800E+00
2.180E+00
2.420E+02
1.860E+01
3.260E+00
1.410E+01
1.180E+01
6.180E+00
H
Y
Y
Y
D
M
M
M
D
H
D
H
D
D
ICRP
Lung
Class*
W
W
W
W
W
D
D
D
W
W
W
W
W
Y
Gl
Absorption
Factor (f,)9
3.0E-04
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E+00
1.0E+00
1.0E+00
3.0E-04
3.0E-04
1.0E-03
1.0E-03
1.0E+00
1.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pd)
4.6E-13
2.1E-12
3.0E-12
4.5E-13
2.5E-12
9.8E-14
5.9E-14
1.7E-13
3.1E-13
5.9E-13
2.1E-13
1.3E-12
6.8E-15
3.9E-13
Inhalation
(Risk/pCi)
3.9E-13
1.1E-10
1.4E-10
1.8E-11
1.1E-11
7.1E-14
9.2E-13
4.2E-13
5.8E-12
6.3E-13
3.6E-13
1.2E-12
1.3E-13
8.7E-13
External Exposure
(Risk/yr per pCi/g soil)
9.4E-07
3.6E-06
4.1E-06
5.9E-08
4.8E-06
3.1E-06
6.2E-08
4.1E-08
7.3E-08
8.9E-08
3.3E-07
9.8E-06
2.3E-1 1
1.3E-06
 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10'" Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN  should be reported for the parent radionuclide and each chain member.
6 Radioactive  half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay  products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionuclide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the User's Guide for instructions.
                                                                                                                                            4A-6

-------
                         Table 4A:  Radionuclide Carcinogenicity - Slope Factors'
                                                      (In  Units of Picocuries")
JANUARY 1992
Element
(Atomic Number)

Hotmium (67)
Hydrogen (1)
Indium (49)




Iodine (53)





Isotope0
Au-198
Ho-166
H-3
ln-113m
ln-114
ln-114m
ln-115
ln-115m
1-122
1-123
1-125
1-126
1-129
1-130
CASRN"
010043-49-0
013967-65-2
010028-17-8
014885-78-0(01)
01398-55-0
01398-55-0(m)
014191-71-0
014191-71-0(m)
018287-75-7
015715-08-9
014158-31-7
014158-32-8
015046-84-1
014914-02-4
Radioactive
Half-life*
2.700E+00
2.680E+01
1.230E+01
1.660E+00
7.190E+01
4.950E+01
4.600E+15
4.360E+00
3.620E+00
1.310E+01
6.010E+01
1.290E+01
1.570E+07
1.240E-I-01
D
H
Y
H
S
D
Y
H
M
H
D
D
Y
H
ICRP
Lung
Class'
Y
W
*
W
W
W
W
W
D
D
D
D
D
D
Gl
Absorption
Factor (f,)8
1.0E-01
3.0E-04
1.0E+00
2.0E-02
2.0E-02
2.0E-02
2.0E-02
2.0E-02
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00 .
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.2E-12
1.7E-12
5.4E-14
4.9E-14
5.5E-15
5.4E-12
3.2E-11
1.2E-13
2.5E-14
1.0E-12
7.9E-12
1.5E-11
1.9E-10
9.1E-12
Inhalation
(Risk/pCi)
2.1E-12
2.2E-12
7.8E-14
2.9E-14
1.5E-15
4.2E-11
2.2E-10
9.4E-14
7.9E-15
5.7E-13
5.3E-12
9.8E-12
1.2E-10
5.1E-12
External Exposure
(Risk/yr per pCi/g soil)
1.2E-06
6.5E-08
O.OE+00
7.0E-07
1.0E-07
1.8E-07
O.OE-t-00
3.9E-07
3.0E-06
2.4E-07
2.9E-09
1.3E-06
4.1E-09
7.0E-06
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10" nudear transformations per second. 1 picocurie (pCi) = 10'" Ci.
c For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also induded.  Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
e Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year. W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.       4A-7

-------
                        Table  4A:  Radionuclide Carcinogenicity  - Slope Factors'
                                                     (In  Units of  Picocuriesb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure

Element
(Atomic Number) Isotope6
1-131
1-132
1-133
1-134
1-135
lr-190
Indium (77) lr-192
lr-194
Iron (26) Fe-55
Fe-59
Krypton (36) Kr-83m
Kr-85
r\i ^o J
Kr-85m
Kr-87

CASRNd
010043-66-0
014683-16-0
014834-67-4
014914-27-3
014834-68-5
014981-91-0
014694-69-0
014158-35-1
014681-59-5
014596-12-4
013965-98-5(m)
013983-27-2
013983-27-2(m)
014809-68-8


Radioactive
Hall-life8
8.040E+00
2.300E-I-00
2.080E+01
5.260E+01
6.610E+00
1.180E+01
7.400E+01
1.920E+01
2.700E+00
4.460E+01
1.830E+00
1 .070E+01
4.480E+00
7.630E+01
D
H
H
M
H
D
D
H
Y
D
H
V
1
H
M
ICRP
Lung
Class'
D
D
D
0
D
Y
Y
Y
W
W
*
*
•
•
Gl
Absorption
Factor (f,)g
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E-02
1.0E-02
1.0E-02
1.0E-01
1.0E-01
1.0E+00
1 OF+00
1 .VCTW
1.0E+00
I.OE-t-00

Ingestion
(Risk/pCi)
3.6E-1 1
1.0E-12
2.1E-11
2.8E-13
4.2E-12
1.4E-12
1.7E-12
1.6E-12
2.7E-13
2.8E-12








Inhalation
(Risk/pCi)
2.4E-1 1
5.8E-13
1.2E-11
1.6E-13
2.4E-12
4.8E-12
2.7E-1 1
1.8E-12
8.4E-13
9.7E-12
6.2E-17
A 7C.17
•r. I C 1 '
4.9E-16
2.2E-15

External Exposure
(Risk/yr per pCi/g soil)
1.5E-06
7.7E-06
2.0E-06
9.0E-06
5.5E-06
4.2E-06
2.4E-06
2.8E-07
O.OE+00
4.1E-06
3.4E-1 1
7.0E-09
3.4E-07
2.8E-06
0 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10'2 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
9 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
'  Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the User's Guide for instructions.
           4A-8

-------
                        Table 4A: Radionuclide Carcinogenicity -- Slope Factors'
                                                    (In Units of Picocuriesb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Lanthanum (57)
Lead (82)






Lutetium (71)
Manganese (25)

Isotope0
Kr-88
Kr-89
Kr-90
La-140
Pb-203
Pb-209f
Pb-210t
Pb-210+D
Pb-211r
Pb-212T
Pb-214T
Lu-177
Mn-52
Mn-54
CASRN"
014995-61-0
016316-03-3
015741-13-6
013981-28-7
014687-25-3
014119-30-3
014255-04-0
014255-04-0(+D)
015816-77-0
015092-94-1
015067-28-4
014265-75-9
014092-99-0
013966-31-9
Radioactive
Half-life"
2.840E+00
3.160E+00
3.230E+01
4.020E+01
5.200E+01
3.250E+00
2.230E+01
2.230E+01
3.610E+01
1.060E+01
2.680E-H01
6.710E+00
5.590E+00
3.130E+02
H
M
S
H
H
H
Y
Y
M
H
M
D
D
0
ICRP
Lung
Class'
*
*
•
W
D
D
D
D
0
D
D
Y
W
W
Gl
Absorption
Factor (f,)9
1.0E+00
1.0E+00
1.0E+00
1.0E-03
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
3.0E-04
1.0E-01
1.0E-01
Ingestion
(Risk/pCi)



2.3E-12
3.2E-13
8.5E-14
5.1E-10
6.6E-10
1.8E-13
5.5E-12
1.7E-13
6.2E-13
2.2E-12
1.1E-12
Inhalation
(Risk/pCi)
4.7E-15
2.6E-15
2.4E-15
3.0E-12
2.6E-13
7.0E-14
1.3E-09
4.0E-09
2.8E-12
4.3E-1 1
2.9E-12
1.9E-12
3.7E-12
5.3E-12
External Exposure
(Risk/yr per pCi/g soil)
7.3E-06
6.5E-06
4.2E-06
8.0E-06
5.9E-07
O.OE+00
1.3E-10
1.6E-10
1.6E-07
2.8E-07
6.4E-07
6.7E-08
1.2E-05
2.9E-06
8 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 1010 nuclear transformations per second. 1 picocurie (pCi) = 10" Ci.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
0 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by  the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
8 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.       4A-9

-------
                       Table  4A:  Radionuclide Carcinogenicity -  Slope  Factors8
                                                   (In  Units of  Picocuries")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)

Mercury (80)

Molybdenum (42)
Neodymium (60)

Neptunium (93)






Nickel (28)
Isotope0
Mn-56
Hg-197
Hg-203
Mo-99
Nd-147
Nd-149
Np-236
Np-237t
Np-237+D
Np-238
Np-239r
Np-240
Np-240m
Ni-59
CASRN"
014681-52-8
013981-51-6
013982-78-0
014119-15-4
014269-74-0
015749-81-2
015700-36-4
013994-20-2
013994-20-2(+D)
015766-25-3
013968-59-7
015690-84-3
015690-84-3(m)
014336-70-0
Radioactive
Half-life"
2.580E+00
6.410E+01
4.660E+01
6.600E+01
1.100E+01
1.730E+00
1.150E+05
2.140E+06
2.140E+06
2.120E+00
2.360E+00
6.500E-f01
7.400E-t-00
7.500E+04
H
H
D
H
D
H
Y
Y
Y
0
D
M
M
Y
ICRP
Lung
Class'
W
W
W
Y
Y
Y
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)8
1.0E-01
2.0E-02
2.0E-02
8.0E-01
3.0E-04
3.0E-04
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
5.0E-02
Ingestion
(Risk/pCi)
4.0E-13
2.7E-13
6.6E-13
1.5E-12
1.3E-12
1.9E-13
2.3E-13
2.2E-10
2.2E-10
1.1E-12
9.4E-13
1.3E-13
2.9E-14
9.1E-14
Inhalation
(Risk/pCi)
2.8E-13
4.5E-13
4.8E-12
2.6E-12
5.5E-12
1.6E-13
3.9E-12
2.9E-08
2.9E-08
3.3E-12
1.5E-12
6.5E-14
9.0E-15
7.0E-13
External Exposure
(Risk/yr per pCi/g soil)
6.1E-06
5.5E-08
5.7E-07
4.9E-07
3.0E-07
9.8E-07
8.9E-08
7.8E-09
4.3E-07
1.7E-06
2.3E-07
3.2E-06
9.3E-07
O.OE+00
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to tfie User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10" Ci.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a'+ D' to indicate that the
risks from radioactive decay chain products are also included.  Radionudides designated with a T are members of a decay chain.
" Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
e Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
 Lung clearance classification recommended by the International Commission  on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
8 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) Inhalation or ingestion slope factors. See the User's Guide for instructions.      4A-10

-------
                         Table 4A: Radionuclide Carcinogenicity --  Slope  Factors'
                                                     (In  Units of  Picocuries")
JANUARY 1982
Element
(Atomic Number) Isotope0
Ni-63
Ni-65
Niobium (41) Nb-93m
Nb-94
Nb-95
Nb-95m
Nb-97
Nb-97m
Osmium (76) Os-185
Os-191
Os-191m
Os-193
Palladium (46) Pd-100
Pd-101
CASRN"
013981-37-8
014833-49-9
007440-03-1 (m)
014681-63-1
013967-76-5
013967-76-5(m)
018496-04-3
018496-04-3(m)
015766-50-4
014119-24-5
014119-24-5(m)
016057-77-5
015690-69-4
015749-54-9
Radioactive
Half-life0
1.000E+02
2.520E+00
1.460E+01
2.030E+04
3.510E+01
8.660E+01
7.210E+01
6.000E+01
9.360E+01
1.540E+01
1.300E+01
3.000E+01
3.640E+00
8.480E+00
Y
H
Y
Y
D
H
M
S
D
D
H
H
D
H
ICRP
Lung
Class*
W
W
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Gl
Absorption
Factor (f,)9
5.0E-02
5.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
5.0E-03
5.0E-03
Ingestion
(Risk/pCi)
2.4E-13
2.6E-13
1.5E-13
2.1E-12
6.5E-13
6.6E-13
1.2E-13
2.4E-15
6.3E-13
6.7E-13
1.2E-13
9.6E-13
1.0E-12
1.2E-13
Inhalation
(Risk/pCi)
1.8E-12
1.9E-13
1.9E-11
2.1E-10
5.1E-12
1.6E-12
6.9E-14
1.1E-15
8.9E-12
3.6E-12
2.1E-13
1.2E-12
2.3E-12
1.1E-13
External Exposure
(Risk/yr per pCi/g soil)
O.OE+00
1.9E-06
5.3E-1 1
5.4E-06
2.6E-06
8.1E-08
2.2E-06
2.5E-06
2.2E-06
8.5E-08
3.4E-09
1.7E-07


a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci). the customary unit of activity, is equal to 3.7 x 10" nudear transformations per second. 1 picocurie (pCi) = 10'<: Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a '+0* to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day,' = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.       4A-11

-------
                        Table 4A: Radionuclide Carcinogenicity -  Slope  Factors8
                                                     (In  Units of Picocuries")
JANUARY 1982
Element
(Atomic Number) Isotope0
Pd-103
Pd-107
Pd-109
Phosphorus (15) P-32
P-33
Platinum (78) Pt-191
Pt-193
Pt-193m
Pt-197
Pt-197m
Plutonium (94) Pu-236
Pu-238
Pu-239
Pu-240
CASRN"
014967-68-1
017637-99-9
014981-64-7
014596-37-3
015749-66-3
015706-36-2
015735-70-3
015735-70-3(m)
015735-74-7
015735-74-7(01)
015411-92-4
013981-16-3
015117-48-3
014119-33-6
Radioactive
Half-life*
1.700E+01
6.500E+06
1.350E+01
1.430E+01
2.540E+01
2.710E+00
5.000E+01
4.330E+00
1.830E+01
9.440E+01
2.850E+00
8.780E+01
2.410E+04
6.570E+03
D
Y
H
0
D
D
Y
D
H
M
Y
Y
Y
Y
ICRP
Lung
Class'
Y
Y
Y
D
D
D
D
D
D
0
Y
Y
Y
Y
Gl
Absorption
Factor (f,)8
5.0E-03
5.0E-03
5.0E-03
8.0E-01
8.0E-01
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-03
1.0E-03
1.0E-03
1.0E-03
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
2.2E-13
4.4E-14
7.9E-13
3.5E-12
5.6E-13
3.8E-13
3.5E-14
5.3E-13
4.9E-13
1.2E-13
5.0E-11
2.2E-10
2.3E-10
2.3E-10
Inhalation
(Risk/pCi)
1.4E-12
6.4E-12
8.1E-13
3.0E-12
4.6E-13
3.0E-13
8.2E-14
4.0E-13
3.2E-13
8.7E-14
2.4E-08
3.9E-08
3.8E-08
3.8E-08
External Exposure
(Risk/yr per pCi/g soil)
7.3E-10
O.OE+00
2.2E-09
O.OE+00
O.OE+00
6.3E-07
O.OE+00
7.6E-09
3.1E-08
1.6E-07
3.4E-11
2.8E-1 1
1.7E-11
2.7E-11
 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
6 A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10" Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a %-D" to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
a Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission  on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the User's Guide for instructions.       4A-12

-------
                         Table 4A:  Radionuclide Carcinogenicity  - Slope Factors'
                                                      (In Units of  Picocuriesb)
JANUARY 1992
Element
(Atomic Number)




Polonium (84)






Potassium (19)

Praseodymium (59)
Isotope0
Pu-241
Pu-242
Pu-243
Pu-244
Po-210f
Po-212f
Po-213f
Po-214f
Po-215r
Po-216'
Po-218'
K-40
K-42
Pr-142
CASRNd
014119-32-5
013982-10-0
015706-37-3
014119-34-7
013981-52-7
015389-34-1
015756-57-7
015735-67-8
015706-52-2
015756-58-8
015422-24-9
013966-00-2
014378-21-3
014191-64-1
Radioactive
Half-life"
1.440E+01
3.760E+05
4.960E+00
8.260E-f07
1.380E-f02
2.980E-07
4.200E-06
1.640E-04
1.780E-03
1.460E-01
3.050E+00
1.280E-f09
1.240E+01
1.910E+01
Y
Y
H
Y
D
S
S
S
S
S
M
Y
H
H
ICRP
Lung
Class'
Y
Y
Y
Y
W
W
W
W
W
W
W
D
D
Y
Gl
Absorption
Factor (f,)9
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E+00
1.0E+00
3.0E-04
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
3.6E-12
2.2E-10
1.1E-13
2.2E-10
1.5E-10
2.2E-23
3.2E-22
1.0E-20
2.8E-19
3.0E-17
2.8E-14
1.1E-11
8.9E-13
1.6E-12
Inhalation
(Risk/pCi)
2.3E-10
3.6E-08
1.0E-13
3.6E-08
2.6E-09
6.1E-22
8.0E-21
2.8E-19
5.7E-18
4.8E-16
5.8E-13
7.6E-12
1.2E-12
1.8E-12
External Exposure
(Risk/yr per pCi/g soil)
O.OE+00
2.3E-1 1
1.8E-08
1.9E-11
2.9E-1 1
O.OE+00
1.0E-10
2.8E-10
4.6E-10
5.0E-11
O.OE-fOO
5.4E-07
9.6E-07
2.1E-07
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 1012 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
9 Radioactive half-life: S = Second, M = Minute, 0 = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International  Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
8 Gl absorption factors are the fractional amount of the radionuclide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the User's Guide for instructions.       4A-13

-------
                        Table 4A: Radionuclide Carcinogenicity  - Slope Factors'
                                                     (In  Units of  Picoburiesb)
JANUARY 1992
Element
(Atomic Number)



Promethium(61)



Protactinium (91)



Radium (88)


Isotope0
Pr-143
Pr-144
Pr-144m
Pm-147
Pm-148
Pm-148m
Pm-149
Pa-231T
Pa-233f
Pa-234
Pa-234mf
Ra-223t
Ra-224f
Ra-225f
CASRN"
014981-79-4
014119-05-2
014119-05-2(m)
014380-75-7
014683-19-3
01 4683-1 9-3(m)
015765-31-8
014331-85-2
013981-14-1
015100-28-4
015100-28-4(m)
015623-45-7
013233-32-4
013981-53-8
Radioactive
Half-life0
1.360E+01
1.730E+01
7.200E+00
2.620E+00
5.370E+00
4.130E+01
5.310E+01
3.730E+04
2.700E+01
6.700E+00
1.170E+00
1.140E+01
3.620E+00
1.480E+01
D
M
M
Y
D
D
H
Y
D
H
M
D
D
D
ICRP
Lung
Class'
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
Gl
Absorption
Factor (f,)9
3.0E-04
3.0E-04
3.0E-04
3.0E-04
3.0E-04
3.0E-04
3.0E-04
1.0E-03
1.0E-03
1.0E-03
1.0E-03
2.0E-01
2.0E-01
2.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.4E-12
9.5E-14
3.7E-14
3.1E-13
3.1E-12
2.5E-12
1.2E-12
9.2E-11
1.0E-12
6.8E-13
5.8E-15
6.4E-11
3.8E-1 1
5.1E-11
Inhalation
(Risk/pCi)
7.0E-12
3.6E-14
1.6E-14
3.0E-1 1
7.9E-12
4.8E-1 1
1.9E-12
3.6E-08
8.6E-12
5.4E-13
1.6E-15
3.1E-09
1.2E-09
1.5E-09
External Exposure
(Risk/yr per pCi/g soil)
3.0E-14
1.2E-07
2.1E-09
6.0E-12
1.9E-06
6.5E-06
3.3E-08
2.6E-08
4.2E-07
5.9E-06
3.6E-08
2.3E-07
2.3E-08
1.9E-09
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10" nuclear transformations per second. 1 picocurie (pCi) = 10'12 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionudide only, except when marked with a %-D" to indicate that the
risks from radioactive decay chain products are also included.  Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute. D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission  on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
8 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.       4A-14

-------
                        Table 4A:  Radionuclide Carcinogenicity  - Slope Factors'
                                                    (In Units of Picocuries")
                                                                                                                                JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope6
Ra-226*
Ra-226+D
Ra-228*
Ra-228+D
Radon (86) Rn-219'
Rn-220'
Rrt-222T
Rn-222+D
Rhodium (45) Rh-103m
Rh-105
Rh-105m
Rh-106
Rubidium (37) Rb-82
Rb-86
CASRN"
013982-63-3
013982-63-3(-fD)
015262-20-1
01 5262-20-1 (+D)
014835-02-0
022481-48-7
014859-67-7
014859-67-7(+D)
007440-16-6(m)
014913-8*4
014913^89-4(m)
013967-48-1
014391-63-0
014932-53-7
Radioactive
Half-life0
1.600E+03
1.600E+03
5.750E-1-00
5.750E+00
3.960E+00
5.560E+01
3.820E+00
3.820E+00
5.610E+01
3.540E+01
4.500E+01
2.990E+01
1.250E+00
1.870E+01
Y
Y
Y
Y
S
S
D
D
M
H
S
S
M
D
ICRP
Lung
Class'
W
W
W
W
*
•
*
*
Y
Y
Y
Y
D
D
Gl
Absorption
Factor (f,)9
2.0E-01
2.0E-01
2.0E-01
2.0E-01
1.0E+00
1.0E-fOO
1.0E+00
1.0E+00
5.0E-02
5.0E-02
5.0E-02
5.0E-02
1.0E+00
1.0E+00
Ingestion
(Risk/pCi)
1.2E-10
1.2E-10
1.0E-10
1.0E-10

1.4E-12
1.7E-12
6.9E-15
4.3E-13
6.2E-16
4.4E-15
1.2E-14
5.9E-12
Inhalation
(Risk/pCi)
3.0E-09
3.0E-09
6.6E-10
6.9E-10
4.6E-14
1.2E-13
7.3E-13
7.7E-12
3.9E-15
5.9E-13
3.4E-16
1.2E-15
3.5E-15
4.5E-12
External Exposure
(Risk/yr per pCi/g soil)
1.2E-08
6.0E-06
O.OE+00
2.9E-06
1.6E-07
1.7E-09
1.2E-09
5.9E-06
7.9E-11
2.2E-07
2.2E-08
6.7E-07
3.5E-06
3.3E-07
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10" nudear transformations per second. 1 picocurie (pCi) = 10 '2 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a %D" to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each -chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1                                                                                                                     *
  Lung dearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestibn slope factors.  See the User's Guide for instructions.
                                                                                                                                          4A-15

-------
                        Table 4A:  Radionuclide Carcinogenicity  -- Slope  Factors'
                                                    (In Units of Picocuries")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)



Ruthenium (44)



Samarium (62)


Scandium (21)


Selenium (34)
Isotope0
Rl>87
Rb-88
Rb-89
Ru-97
Ru-103
Ru-105
Ru-106
Sm-147
Sm-151
Sm-153
Sc-46
Sc-47
Sc-48
Se-75
CASRNd
013982-13-3
014928-36-0
. 014191-65-2
015758-35-7
013968-53-1
014331-9&4
013967-48-1
014392-33-7
015715-94-3
015766-00-4
013967-634
014391-96-9
014391-86-7
014265-71-5
Radioactive
Half-life0
4.730E+10
1.780E+01
1.540E+01
2.900E+00
3.940E+01
4.440E+00
3.680E+02
1.060E+11
9.000E+01
4.670E+01
8.380E+01
3.420E+00
4.370E+01
1.200E-f02
Y
M
M
D
D
H
D
Y
Y
H
D
D
H
D
ICRP
Lung
Class'
D
D
D
Y
Y
Y
Y
W
W
W
Y
Y
Y
W
Gl
Absorption
Factor (f,)9
1.0E+00
1.0E+00
1.0E+00
5.0E-02
5.0E-02
5.0E-02
5.0E-02
3.0E-04
3.0E-04
3.0E-04
1.0E-04
1.0E-04
1.0E-04
8.0E-01
Ingestion
(Risk/pCi)
3.4E-12
1.7E-13
9.3E-14
1.7E-13
9.0E-13
3.7E-13
9.5E-12
1.6E-11
1.1E-13
8.7E-13
1.6E-12
6.4E-13
1.9E-12
5.8E-12
Inhalation
(Risk/pCi)
2.4E-12
7.9E-14
3.9E-14
2.6E-13
8.4E-12
3.3E-13
•4.4E-10
7.2E-09
8.7E-12
1.3E-12
2.7E-11
1.2E-12
2.3E-12
6.0E-12
External Exposure
(Risk/yr per pCi/g soil)
O.OE+00
2.4E-06
7.4E-06
4.2E-07
1.5E-06
2.6E-06
O.OE+00
O.OE-fOO
4.0E-13
4.6E-08
6.9E-06
2.3E-07
1.2E-05
8.1E-07
3
 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10'12 Ci.
c For each radionuclide listed,  corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D* to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a 'f are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive  half-life: S = Second, M = Minute, D = Day, Y = Year. For ttiose radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionuclide absorbed across the Gl tract into the bloodstream. Lung classifications  and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.      4 A- 16

-------
                        Table  4A:  Radionuclide Carcinogenicity  -- Slope  Factors'
                                                     (In  Units of Picocuriesb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Silicon (14)
Silver (47)





Sodium (11)

Strontium (38)



Isotope0
Si-31
Ag-105
Ag-108
Ag-108m
Ag-109m
Ag-110
Ag-110m
Ag-111
Na-22
Na-24
Sr-82
Sr-85
Sr-85m
Sr-89
CASRN"
014276-49-4
014928-14-4
014391-65-2
014391-€5-2(m)
014378-38-2(m)
014391-76-5
014391-76-5(m)
0157690-04-0
013966-32-0
013982-04-2
014809-50-8
013967-73-2
013967-73-2(m)
014158-27-1
Radioactive
Half-life6
1.570E+02
4.130E+01
2.370E+00
1.270E+02
3.960E+01
2.460E-.-01
2.500E+02
7.460E+00
2.600E+00
1.500E+01
2.500E+01
6.480E+01
6.770E+01
5.060E+01
M
0
M
Y
S
S
D
D
Y
H
D
D
M
D
ICRP
Lung
Class'
W
Y
Y
Y
Y
Y
Y
Y
D
D
D
D
0
D
Gl
Absorption
Factor (f,)9
1.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
1.0E+00
1.0E+00
3.0E-01
3.0E-01
3.0E-01
3.0E-01
Ingestion
(Risk/pCi)
2.2E-13
7.3E-13
8.5E-15
3.5E-12
3.3E-16
3.0E-15
4.7E-12
1.6E-12
6.8E-12
1.0E-12
7.5E-12
7.7E-13
1.2E-14
3.0E-12
Inhalation
(Risk/pCi)
1.7E-13
4.0E-12
2.4E-15
1.5E-10
8.9E-17
8.1E-16
6.9E-1 1
4.8E-12
4.8E-12
9.6E-13
6.9E-12
1.0E-12
6.1E-15
2.9E-12
External Exposure
(Risk/yr per pCi/g soil)
3.0E-09
5.1E-08
5.0E-06
1.3E-09
1.0E-07
9.3E-06
7.7E-08
7.2E-06
1.6E-05
1.3E-10
1.4E-06
4.8E-07
4.7E-10
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
" A curie (Ci). the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 1012 Ci.
c For each radionuclide listed,  corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a m+D" to indicate that the
risks from radioactive decay chain products are also included.  Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year. W = Week, D = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.      4A-17

-------
                        Table 4A:  Radionuclide  Carcinogenicity -- Slope Factors'
                                                     (In Units  of Picocuriesb)
JANUARY 1992
Element
(Atomic Number) Isotope0
Sr-90t
Sr-90+D
Sr-91
Sr-92
Sulfur (16) S-35
Tantalum (73) Ta-182
Technetium (43) Tc-95
Tc-95m
Tc-96
Tc-96m
Tc-97
Tc-97m
Tc-99
Tc-99m
CASRNd
010098-97-2
010098-97-2(-fD)
014331-91-0
014928-29-1
015117-53-0
013982-00-8
014809-56-4
014809-56-4(m)
014808-44-7
014808-44-7(m)
015759-35-0
015759-35-0(m)
014133-76-7
014133-76-7(m)
Radioactive
Half-life*
2.860E-I-01
2.860E+01
9.500E+00
2.710E+00
8.740E+01
1.150E+02
2.000E+01
6.100E+01
4.280E+00
5.150E+01
2.600E+06
8.900E+01
2.130E+05
6.020E+00
Y
Y
H
H
D
D
H
D
D
M
Y
D
Y
H
ICRP
Lung
Class'
D
D
D
D
D
Y
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)9
3.0E-01
3.0E-01
3.0E-01
3.0E-01
8.0E-01
1.0E-03
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
3.3E-1 1
3.6E-11
8.5E-13
5.7E-13
2.2E-13
1.7E-12
5.6E-14
1.8E-12
1.8E-12
2.3E-14
1.5E-13
1.1E-12
1.3E-12
5.0E-14
Inhalation
(Risk/pCi)
5.6E-11
6.2E-11
6.9E-13
4.5E-13
1.9E-13
4.3E-11
2.3E-14
4.0E-12
2.1E-12
2.1E-14
9.8E-13
5.0E-12
8.3E-12
£7E-14
External Exposure
(Risk/yr per pCi/g soil)
O.OE+00
O.OE+00
2.4E-06
4.6E-06
O.OE+00
4.1E-06
2.4E-06
1.9E-06
8.3E-06
7.0E-08
3.5E-10
3.7E-10
6.0E-13
2.3E-07
" Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
6 A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10" Ci.
c For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a %-D' to indicate that the
risks from radioactive decay chain products are also included.  Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
a Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on  Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
8 Gl absorption factors are the fractional amount of the radionuclide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.      4A-18

-------
                        Table 4A: Radionuclide Carcinogenicity -  Slope  Factors'
                                                     (In Units of Picocuriesb)
JANUARY 1992
Element
(Atomic Number) Isotope0
Tellurium (52) Te-125m
Te-127
Te-127m
Te-129
Te-129m
Te-131
Te-131m
Te-132
Terbium (65) Tb-158
Tb-160
Thallium (81) TI-202
TI-204
T\-20r
11-208*
CASRN"
014390-73-9(m)
013981-49-2
013981-49-2(m)
014269-71-7
014269-71-7(m)
014683-12-6
014683-12-6(m)
014234-28-7
015759-55-4
013981-29-8
015720-57-7
013968-51-9
014133-67-6
014913-50-9
Radioactive
Half-life0
5.800E+01
9.350E+00
1.090E+02
6.960E+01
3.360E+01
2.500E+01
3.000E+01
7.820E+01
1.500E-t-02
7.230E+01
1.220E+01
3.780E+00
4.770E+00
3.050E+00
D
H
D
M
D
M
H
H
Y
D
D
Y
M
M
ICRP
Lung
Class'
W
W
W
W
W
W
W
W
W
W
D
D
D
D
Gl
Absorption
Factor (f,)B
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
3.0E-04
3.0E-04
1.0E+00
1.0E+00
1.0E+00
1.0E+00
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
8.5E-13
2.3E-13
2.2E-12
1.1E-13
3.2E-12
2.8E-13
3.8E-12
3.0E-12
1.2E-12
1.8E-12
8.4E-13
1.7E-12
1.3E-14
1.8E-14
Inhalation
(Risk/pCi)
5.4E-12
2.3E-13
1.6E-11
6.8E-14
2.0E-1 1
1.4E-13
5.4E-12
5.3E-12
9.4E-1 1
1.9E-11
6.0E-13
1.3E-12
4.5E-15
5.0E-15
External Exposure
(Risk/yr per pCi/g soil)
2.6E-09
1.4E-08
8.4E-10
1.3E-07
6.3E-08
1.2E-06
4.7E-06
4.0E-07
3.6E-06
1.3E-06
8.7E-10
7.5E-09
1.3E-05
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
6 A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10'12 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D* to indicate that the
risks from radioactive decay chain products are also included.  Radionudides designated with a "t" are members of a decay chain.
" Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second,  M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
f Lung clearance classification recommended by the International Commission on Radiological Protection  (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.      4A-19

-------
                         Table 4A: Radionuclide Carcinogenicity -- Slope Factors'
                                                     (In  Units of  Picocuriesb)
JANUARY 1982
Element
(Atomic Number) Isotope0
11-209*
Thorium (90) 171-227*
111-228'
Th-228+D
Th-229f
Th-229+D
111-230'
Th-231f
Th-2321
Th-234*
Thulium (69) Tm-1 70
Tm-171
Tin (50) Sn-113
Sn-121
CASRNd
015690-73-0
015623-47-9
014274-82-9
014274-82-9(+D)
015594-54-4
015594-54-4(+D)
014269-63-7
014932-40-2
2007440-29-1
015065-10-8
013981-30-1
014333-45-0
013966-06-8
014683-06-8
Radioactive
Half-life*
2.200E+00
1.870E+01
1.910E+00
1.910E+00
7.340E+03
7.340E+03
7.700E+04
2.550E+01
1.410E+10
2.410E+01
1.290E+02
1.920E+00
1.150E+02
2.710E+01
M
D
Y
Y
Y
Y
Y
H
Y
D
D
Y
D
H
ICRP
Lung
Class'
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
W
Gl
Absorption
Factor (f,)g
1.0E+00
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
3.0E-04
3.0E-04
2.0E-02
2.0E-02
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.4E-14
4.5E-12
1.1E-11
5.5E-11
2.1E-11
8.9E-11
1.3E-11
4.0E-13
1.2E-11
4.0E-12
1.5E-12
1.2E-13
8.7E-13
2.7E-13
Inhalation
(Risk/pCi)
4.3E-15
4.9E-09
7.7E-08
7.8E-08
7.3E-08
7.7E-08
2.9E-08
4.9E-13
2.8E-08
3.2E-11
2.1E-11
3.1E-12
9.4E-12
3.2E-13
External Exposure
(Risk/yr per pCi/g soil)
6.9E-06
1.6E-07
5.5E-10
5.6E-06
5.8E-08
6.8E-07
5.4E-1 1
2.3E-09
2.6E-11
3.5E-09
3.8E-09
3.3E-10
3.3E-09

a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10'12 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a '+D' to indicate that the
risks from radioactive decay chain products are also included.  Radionudides designated with a "f" are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.       4A-20

-------
                         Table 4A: Radionuclide  Carcinogenicity  - Slope Factors'
                                                     (In  Units  of Picocuries")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Sn-121m
Sn-125
Sn-126
Tungsten (74) W-181
W-185
W-187
Uranium (92) U-232
U-233
U-234'
U-235'
U-235+D
U-236
U-237
11-238*
CASRN"
014683-06-8(m)
014683-08-0
015832-50-5
015749-46-9
014932-41-3
014983-48-3
014158-29-3
013968-55-3
013966-29-5
015117-96-1
015117-96-1(+D)
013982-70-2
014269-75-1
007440-61-1
Radioactive
Half-life0
5.550E+01
9.640E+00
1.000E+05
1.210E+02
7.510E+01
2.380E+01
7.200E+01
1.590E+05
2.450E-f05
7.040E+08
7.040E+08
2.340E+07
6.750E+00
4.470E+09
Y
D
Y
D
D
H
Y
Y
Y
Y
Y
Y
D
Y
ICRP
Lung
Class1
W
W
W
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Gl
Absorption
Factor (f,)fl
2.0E-02
2.0E-02
2.0E-02
3.0E-01
3.0E-01
3.0E-01
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
Ingestion
(Risk/pCi)
5.4E-13
3.6E-12
5.6E-12
8.3E-14
4.7E-13
6.3E-13
3.7E-11
1.6E-11
1.6E-11
1.6E-11
1.6E-11
1.5E-11
8.9E-13
1.6E-11
Inhalation
(Risk/pCi)
9.3E-12
1.2E-11
7.7E-1 1
6.4E-14
3.0E-13
3.9E-13
6.0E-08
2.7E-08
2.6E-08
2.5E-08
2.5E-08
2.5E-08
2.6E-12
2.4E-08
External Exposure
(Risk/yr per pCi/g soil)

1.1E-06
3.3E-08
2.2E-08
4.7E-1 1
1.5E-06
4.6E-11
4.2E-11
3.0E-1 1
2.4E-07
2.4E-07
2.4E-11
1.3E-07
2.1E-11
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10'" Ci.
c For each radionuclide listed, corresponding slope /actors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also induded.  Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
9 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year. W = Week, D = Day. * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e.. multiply  or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.      4A-21

-------
                        Table 4A: Radionuclide Carcinogenicity -- Slope Factors'
                                                    (In Units of Picocuries")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
U-238+D
U-240
Vanadium (23) V-48
Xenon (54) Xe-122
Xe-123
Xe-125
Xe-127
Xe-129m
Xe-131m
Xe-133
Xe-133m
Xe-135
Xe-135m
Xe-137
CASRNd
007440-«1-1(+D)
015687-53-3
014331-97-6
015151-09-4
015700-10-4
013994-18-8
013994-19-9
013965-99-6(m)
014683-11-5(01)
014932-42-4
014932-42-4(m)
014995-62-1
014995-62-1(01)
014835-21-3
ICRP Gl
Radioactive Lung Absorption Ingestion
Half-life* Class* Factor (f,)9 (Risk/pCi)
4.470E+09
1.410E+01
1.600E+01
2.010E+01
2.140E+00
1.680E+01
3.640E+01
8.890E+00
1.180E+01
5.250E+00
2.190E+00
9.110E+00
1.540E+01
3.830E+00
Y Y 5.0E-02 2.8E-11
H Y 5.0E-02 1.2E-12
D W 1.0E-02 2.2E-12
H* 1 OF+QO
H* 1 nFinn
H* 1 OF i on



D* 1 nF inn
D* 1 OFj-OO
H* 1 OFifJO
M* 1 nF i nn
M* 1 nF ion

Inhalation
(Risk/pCi)
5.2E-08
1.2E-12
7.6E-12
3.3E-15
7.4E-16
4.2E-16
4.0E-16
6.0E-16
4.3E-16
4.3E-16
5.4E-16
8.0E-16
2.1E-16
1.8E-15
External Exposure
(Risk/yr per pCi/g soil)
3.6E-08
1.5E-10
9.9E-06
8.4E-08
1.7E-06
4.7E-07
5.0E-07
1.3E-08
4.5E-09
2.3E-08
3.3E-08
6.2E-07
1.3E-06
6.0E-07
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10'12 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided tor reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the User's Guide for instructions.      4A-22

-------
                        Table 4A: Radionuclide Carcinogenicity - Slope Factors8
                                                    (In  Units of  Picocuries")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake Of Exposure
Element
(Atomic Number)

Yttrium (39)




Zinc (30)


Zirconium (40)


Isotope0
Xe-138
Y-90'
Y-91
Y-91m
Y-92
Y-93
Zn-65
Zn-69
Zn-69m
Zr-93
Zr-95
Zr-97
CASRNd
015751-81-2
010098-91-6
014234-24-3
014234-24-3(m)
015751-594
014981-70-5
013982-39-3
013982-23-5
013982-23-5(m)
015751-77-6
013967-71-0
014928-30-4
Radioactive
Half-life0
1.410E+01
6.410E+01
5.850E+01
4.970E+01
3.540E+00
1.010E+01
2.440E+02
5.560E+01
1.380E+01
1.530E+06
6.400E-t-01
1.690E+01
M
H
D
M
H
H
D
M
H
Y
0
H
ICRP
Lung
Class'
*
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
Gl
Absorption
Factor (f,)g
1.0E+00
1.0E-04
1.0E-04
1.0E-04
1.0E-04
1.0E-04
5.0E-01
5.0E-01
5.0E-01
2.0E-03
2.0E-03
2.0E-03
Ingestion
(Risk/pCi)
	
3.2E-12
2.8E-12
2.2E-14
7.1E-13
1.4E-12
8.5E-12
5.6E-14
4.3E-13
1.7E-13
9.9E-13
2.4E-12
Inhalation
(Risk/pCi)
2.8E-15
5.5E-12
4.8E-1 1
3.5E-14
5.8E-13
1.4E-12
1.6E-11
3.2E-14
5.7E-13
6.5E-12
1.0E-11
2.5E-12
External Exposure
(Risk/yr per pCi/g soil)
4.0E-06
O.OE+00
1.2E-08
1.7E-06
8.6E-07
3.0E-07
2.0E-06
1.8E-11
1.3E-06
O.OE+00
2.5E-06
6.1E-07
8 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 1010 nudear transformations per second. 1 picocurie (pCi) = 1012 Ci.
c For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+0" to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a T are members of a decay chain.
0 Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive  half-life: S = Second, M = Minute, 0 = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission  on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionuclide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.       4A-23

-------
                         Table 4B:  Radionuclide  Carcinogenicity -  Slope  Factors'
                                                     (In Units of  Becquerelsb)
JANUARY 1992
Element
(Atomic Number) Isotope6
Actinium (89) Ac-225'
Ac-aa^
Ac-227+D
Ac-228
Amerlcium (95) Am-241t
Am-242
Am-242m
Am-243*
Am-243+D
Antimony (51) Sb-122
Sb-124
Sb-125
Sb-126
Sb-126m
CASRN"
014265-85-1
014952-40-0
014952-40-0(+D)
014331-83-0
014596-10-2
013981-54-9
013981-54-9(m)
014993-75-0
014993-75-0(+D)
014374-79-9
014683-10-4
014234-35-6
015756-32-8
015756-32-8(m)
Radioactive
Half-life*
1.000E+01
2.180E+01
2.180E+01
6.130E+00
4.320E+02
1.600E+01
1.520E+02
7.380E+03
7.380E+03
2.700E+00
6.020E+01
2.770E+00
1.240E+01
1.900E+01
D
Y
Y
H
Y
H
Y
Y
Y
D
D
Y
D
M
ICRP
Lung
Class*
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)fl
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
4.6E-10
7.6E-09
9.5E-09
1.4E-11
6.5E-09
9.7E-12
6.2E-09
6.5E-09
6.5E-09
5.4E-1 1
7.8E-11
2.3E-11
7.6E-1 1
1.9E-12
Inhalation
(Risk/Bq)
6.5E-08
2.2E-06
2.4E-06
7.0E-10
8.6E-07
3.2E-10
7.6E-07
8.6E-07
8.6E-07
9.2E-1 1
5.9E-10
3.0E-10
2.4E-10
7.0E-13
External Exposure
(Risk/yr per Bq/g soil)
2.1E-07
7.0E-10
2.3E-05
7.8E-05
1.3E-07
1.6E-07
3.2E-09
6.5E-07
6.8E-06
3.8E-05
1.8E-04
3.2E-05
2.5E-04
1.4E-04
8 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
" A becquerel (Bq). the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a *+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second,  M = Minute, D = Day, Y = Year. For those radionudides with decay products (+0), half-lives are listed for the parent radionuclide.
1  Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the User's Guide for instructions.
          4B-1

-------
                        Table  4B:  Radionuclide Carcinogenicity  -- Slope Factors'
                                                    (In  Units of  Becquerelsb)
JANUARY 1992
Element
(Atomic Number)

Argon (18)
Astatine (85)
Barium (56)





Beryllium (4)
Bismuth (83)


Isotope"
Sb-127
Sb-129
Ar-41
At-ai^
Ba-131
Ba-133
Ba-133m
Ba-137mf
Ba-139
Ba-140
Be-7
Bi-206
Bi-207
Bi-210T
CASRN1*
013968-50-8
014331-88-5
014163-25-8
017239-90-6
014914-75-1
013981-41-4
013981-41-4(m)
013981-97-0(m)
014378-25-7
014798-0&4
013966-02-4
015776-19-9
013982-38-2
014331-79-4
Radioactive
Half-life*
3.850E+00
4.400E+00
1.830E+00
3.230E-02
1.180E+01
1.050E+01
3.890E+01
2.550E+00
8.310E+01
1.280E+01
5.340E+01
6.240E+00
3.340E+01
5.010E+00
D
H
H
S
D
Y
H
M
M
D
D
D
Y
D
ICRP
Lung
Class'
W
W
*
D
D
D
D
D
D
D
Y
W
W
W
Gl
Absorption
Factor (f,)9
1.0E-01
1.0E-01
1.0E+00
1.0E+00
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
5.0E-03
5.0E-02
5.0E-02
5.0E-02
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
5.4E-1 1
1.6E-11
1.2E-16
1.3E-11
3.2E-11
1.7E-11
6.5E-14
5.7E-12
7.3E-11
8.1E-13
5.9E-11
3.8E-11
4.3E-1 1
Inhalation
(Risk/Bq)
1.1E-10
1.4E-11
1.6E-14
1.5E-15
9.7E-12
9.7E-11
9.5E-12
1.6E-14
4.1E-12
5.4E-11
7.3E-12
1.2E-10
4.9E-10
2.2E-09
External Exposure
(Risk/yr per Bq/g soil)
5.7E-05
1.3E-04
1.2E-04
2.1E-08
3.2E-05
2.3E-05
2.6E-06
5.4E-05
2.1E-06
1.5E-05
4.1E-06
3.0E-04
1.3E-04
O.OE+00
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a VD" to indicate that the risks
from radioactive decay chain products are also inducted.  Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across  the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided tor reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the User's Guide for instructions.        4B-2

-------
                        Table 4B: Radionuclide Carcinogenicity -  Slope  Factors'
                                                   (In  Units  of Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)




Bromine (35)
Cadmium (20)


Calcium (20)

Carbon (6)
Cerium (58)
Isotope0
Bi-211T
Bi-212t
Bi-213f
Bi-214f
Br-82
Cd-109
Cd-115
Cd-115m
Ca-45
Ca-47
C-11
C-14
C-15
Ce-141
CASRN"
015229-37-5
014913-49-6
015776-20-2
014733-03-0
014686-69-2
014109-32-1
014336-68-6
014336-68-6(m)
013966-05-7
001439-99-2
014333-33-6
014762-75-5
015929-23-4
013967-74-3
Radioactive
Half-life0
2.130E+00
6.055E+01
4.570E+01
1.990E+01
3.530E+01
4.640E+02
5.350E+01
4.460E+01
1.630E+02
4.540E+00
2.050E+01
5.730E+03
2.450E+00
3.250E+01
M
M
M
M
H
D
H
D
D
D
M
Y
S
D
ICRP
Lung
Class'
W
W
W
W
D
Y
Y
Y
W
W
D
*
D
Y
Gl
Absorption
Factor (f,)g
5.0E-02
5.0E-02
5.0E-02
5.0E-02
1.0E+00
5.0E-02
5.0E-02
5.0E-02
3.0E-01
3.0E-01
1.0E+00
LOE-t-00
1.0E-I-00
3.0E-04
Ingestion
(Risk/Bq)
3.3E-13
8.4E-12
6.2E-12
3.5E-12
3.0E-11
2.1E-10
4.6E-1 1
1.4E-10
2.7E-11
5.4E-11
1.3E-12
2.4E-1 1
2.2E-14
2.2E-11
Inhalation
(Risk/Bq)
5.2E-12
1.8E-10
8.1E-12
5.7E-11
2.4E-1 1
1.8E-09
7.0E-1 1
1.1E-09
1.4E-10
1.2E-10
5.7E-13
1.7E-13
5.7E-15
2.3E-10
External Exposure
(Risk/yr per Bq/g soil)
3.6E-06
1.6E-05
1.1E-05
1.4E-04
2.4E-04
2.0E-08
1.7E-05
2.0E-06
1.6E-16
9.7E-05
8.6E-05
O.OE+00
3.5E-06
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a *+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive  half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.        4B-3

-------
                        Table 4B: Radionuclide  Carcinogenicity -  Slope  Factors'
                                                   (In  Units of  Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Ce-143
Ce-144
Cesium (55) Cs-131
Cs-134
Cs-134m
Cs-135
Cs-136
08-137*
Cs-137+D
Cs-138
Chlorine (17) CI-36
CI-38
Chromium (24) Cr-51
Cobalt (27) Co-57
CASRNd
014119-19-8
014762-78-8
014914-76-2
013967-70-9
013967-70-9(m)
015726-30-4
014234-29-8
010045-97-3
010045-97-3(+D)
015758-29-9
013981-43-6
014158-34-0
014392-02-0
013981-50-5
Radioactive
Half-life0
3.300E+01
2.840E+02
9.690E-I-00
2.060E+00
2.900E+00
2.300E+06
1.320E+01
3.020E+01
3.020E+01
3.220E+01
3.010E+05
3.720E+01
2.770E+01
2.710E+02
H
D
D
Y
H
Y
D
Y
Y
M
Y
M
D
D
ICRP
Lung
Class'
Y
Y
D
D
D
D
D
D
D
D
D
D
Y
Y
Gl
Absorption
Factor (f,)a
3.0E-04
3.0E-04
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E-01
3.0E-01
Ingestion
(Risk/Bq)
3.5E-1 1
1.6E-10
3.8E-12
1.1E-09
1.1E-12
1.1E-10
1.8E-10
7.6E-10
7.6E-10
5.1E-12
4.9E-11
6.2E-12
1.2E-12
1.6E-11
Inhalation
(Risk/Bq)
5.9E-11
9.2E-09
2.7E-12
7.6E-10
1.1E-12
7.3E-11
1.2E-10
5.1E-10
5.1E-10
2.6E-12
3.8E-11
3.5E-12
8.1E-12
2.2E-10
External Exposure
(Risk/yr per Bq/g soil)
1.8E-05
6.8E-07
7.6E-08
1.4E-04
5.4E-07
O.OE+00
1.9E-04
O.OE+00
5.4E-05
2.2E-04
O.OE+00
1.5E-04
2.5E-06
5.1E-06
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
" A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq • 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, 0 = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the User's Guide for instructions.        4B-4

-------
                        Table 4B: Radionuclide Carcinogenicity  - Slope Factors'
                                                    (In  Units  of  Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)



Copper (29)
Curium (96)






Dysprosium (66)

Erbium (63)
lsotopec
Co-58
Co-58m
Co-60
Cu-64
Cm-242
Cm-243
Cm-244
Cm-245
Cm-246
Cm-247
Cm-248
Dy-165
Dy-166
Er-169
CASRN*
01381-38-9
01381-38-9(m)
010198-40-0
013981-25-4
015510-73-3
015757-87-6
013981-15-2
015621-76-8
015757-90-1
015758-32-4
015758-33-5
013967-64-1
015840-01-4
015840-13-8
Radioactive
Half-life*
7.080E+01
9.150E+00
5.270E+00
1.270E+01
1.630E+02
2.850E+01
1.810E-t-01
8.500E+03
4.750E+03
1.560E+07
3.390E+05
2.330E+00
8.160E+01
9.400E+00
D
H
Y
H
D
Y
Y
Y
Y
Y
Y
H
H
D
ICRP
Lung
Class'
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)9
3.0E-01
3.0E-01
3.0E-01
5.0E-01
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
3.0E-04
3.0E-04
3.0E-04
Ingestion
(Risk/Bq)
4.3E-11
8.6E-13
4.1E-10
4.6E-12
3.5E-10
5.1E-09
4.3E-09
6.5E-09
6.5E-09
5.9E-09
2.5E-08
4.1E-12
5.1E-11
1.2E-11
Inhalation
(Risk/Bq)
2.6E-10
2.0E-12
4.1E-09
5.4E-12
1.1E-07
7.0E-07
5.9E-07
8.6E-07
8.6E-07
8.1E-07
3.2E-06
3.0E-12
1.4E-10
4.1E-11
External Exposure
(Risk/yr per Bq/g soil)
8.9E-05
1.3E-09
2.3E-04
1.6E-05
9.2E-10
4.3E-06
8.1E-10
1.4E-06
7.3E-10
2.5E-05
5.9E-10
1.5E-06
7.3E-07
2.3E-10
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq). the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a *+D" to indicate that the risks
from radioactive decay chain products are also included.  Radionudides designated with a "t" are members of a decay chain.
a Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.       4B-5

-------
                        Table 4B: Radionuclide Carcinogenicity  -- Slope  Factors'
                                                    (In Units of Becquerelsb)
JANUARY 19ffi
Element
(Atomic Number)

Europium (63)



Florin (9)
Francium (87)

Gadolinium (64)

Gallium (31)

Germanium (32)
Gold (79)
Isotope0
Er-171
Eu-152
Eu-154
Eu-155
Eu-156
F-18
Fr-221f
Fr-223f
Gd-153
Gd-159
Ga-67
Ga-72
Ge-71
Au-196
CASRN"
01 4391 -45-8
014683*3-9
015585-10-1
014391-16-3
014280-35-4
013981-56-1
015756-41-9
015756-98-6
014276-65-4
014041-42-0
014119-09-6
013982-22-4
014374-81-3
014914-16-0
Radioactive
Half-life*
7.520E+00
1.360E+01
8.800E+00
4.960E+00
1.520E+01
1.100E+02
4.800E+00
2.180E+00
2.420E+02
1.860E+01
3.260E+00
1.410E+01
1.180E+01
6.180E+00
H
Y
Y
Y
D
M
M
M
D
H
D
H
0
D
ICRP
Lung
Class'
W
W
W
W
W
D
D
D
W
W
W
W
W
Y
Gl
Absorption
Factor (f,)g
3.0E-04
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E+00
1.0E+00
1.0E+00
3.0E-04
3.0E-04
1.0E-03
1.0E-03
1.0E+00
1.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
1.2E-11
5.7E-11
8.1E-11
1.2E-11
6.8E-11
2.6E-12
1.6E-12
4.6E-12
8.4E-12
1.6E-11
5.7E-12
3.5E-1 1
1.8E-13
1.1E-11
Inhalation
(Risk/Bq)
1.1E-11
3.0E-09
3.8E-09
4.9E-10
3.0E-10
1.9E-12
2.5E-11
1.1E-11
1.6E-10
1.7E-11
9.7E-12
3.2E-11
3.5E-12
2.4E-11
External Exposure
(Risk/yr per Bq/g soil)
2.5E-05
9.7E-05
1.1E-04
1.6E-06
1.3E-04
8.4E-05
1.7E-06
1.1E-06
2.0E-06
2.4E-06
8.9E-06
2.6E-04
6.2E-10
3.5E-05
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
" A becquerel (Bq). the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure tor that radionuclide only, except when marked with a"+D' to indicate that the risks
from radioactive decay chain products are also included.  Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+0), half-lives are listed for the parent radionudide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide tor instructions.        4B-6

-------
                        Table 4B: Radionuclide  Carcinogenicity  - Slope  Factors'
                                                    (In  Units  of Becquerelsb)
JANUARY 1992
Element
(Atomic Number)

Holmium (67)
Hydrogen (1)
Indium (49)




Iodine (53)





lsotopec
Au-198
Ho-166
H-3
ln-113m
ln-114
ln-114m
ln-115
ln-115m
1-122
1-123
1-125
1-126
1-129
1-130
CASRN"
010043-49-0
013967-65-2
010028-17-8
014885-78-0(m)
01398-55-0
01398-55-0(m)
014191-71-0
014191-71-0(m)
018287-75-7
015715-08-9
014158-31-7
014158-32-8
015046-84-1
014914-02-4
Radioactive
Half-life6
2.700E+00
2.680E+01
1.230E+01
1.660E+00
7.190E+01
4.950E+01
4.600E+15
4.360E+00
3.620E+00
1.310E+01
6.010E+01
1.290E+01
1.570E+07
1.240E+01
D
H
Y
H
S
D
Y
H
M
H
D
D
Y
H
ICRP
Lung
Class'
Y
W
*
W
W
W
W
W
D
D
D
D
D
D
Gl
Absorption
Factor (f,)9
1.0E-01
3.0E-04
1.0E+00
2.0E-02
2.0E-02
2.0E-02
2.0E-02
2.0E-02
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
3.2E-11
4.6E-1 1
1.5E-12
1.3E-12
1.5E-13
1.5E-10
8.6E-10
3.2E-12
6.8E-13
2.7E-11
2.1E-10
4.1E-10
5.1E-09
2.5E-10
Inhalation
(Risk/Bq)
5.7E-1 1
5.9E-1 1
2.1E-12
7.8E-13
4.1E-14
1.1E-09
5.9E-09
2.5E-12
2.1E-13
1.5E-11
1.4E-10
2.6E-10
3.2E-09
1.4E-10
External Exposure
(Risk/yr per Bq/g soil)
3.2E-05
1.8E-06
O.OE+00
1.9E-05
2.7E-06
4.9E-06
O.OE+00
1.1E-05
8.1E-05
6.5E-06
7.8E-08
3.5E-05
1.1E-07
1.9E-04
 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionudide only, except when marked with a *+D* to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
1 Lung clearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications  and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.       4B-7

-------
                        Table 4B:  Radionuclide Carcinogenicity --  Slope  Factors'
                                                   (In Units of Becquerelsb)
JWUARY1S92
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)






Indium (77)

Iron (26)
Krypton (36)
Isotope0
1-131
1-132
1-133
1-134
1-135
lr-190
lr-192
lr-194
Fe-55
Fe-59
Kr-83m
Kr-a5
Kr-flSm
Kr-87
CASRNd
010043-66-0
014683-16-0
014834-67-4
014914-27-3
014834-68-5
014981-91-0
014694-69-0
014158-35-1
014681-59-5
014596-12-4
t 013965-98-5(m)
013983-27-2
013983-27-2(m)
014809-68-8
Radioactive
Half-life8
8.040E+00
2.300E+00
2.080E-I-01
5.260E+01
6.610E+00
1.180E+01
7.400E+01
1.920E+01
2.700E+00
4.460E+01
1.830E+00
1.070E+01
4.480E+00
7.630E+01
D
H
H
M
H
D
D
H
Y
D
H
Y
H
M
ICRP
Lung
Class'
D
D
D
D
D
Y
Y
Y
W
W
*
*
*
*
Gl
Absorption
Factor (f,)fl
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E-02
1.0E-02
1.0E-02
1.0E-01
1.0E-01
1.0E+00
1.0E+00
1.0E-I-00
1.0E+00
Ingestion
(Risk/Bq)
9.7E-10
2.7E-11
5.7E-10
7.6E-12
1.1E-10
3.8E-11
4.6E-11
4.3E-1 1
7.3E-12
7.6E-1 1




Inhalation
(Risk/Bq)
6.5E-10
1.6E-11
3.2E-10
4.3E-12
6.5E-1 1
1.3E-10
7.3E-10
4.9E-11
2.3E-1 1
2.6E-10
1.7E-15
1.3E-15
1.3E-14
5.9E-14
External Exposure
(Risk/yr per Bq/g soil)
4.1E-05
2.1E-04
5.4E-05
2.4E-04
1.5E-04
1.1E-04
6.5E-05
7.6E-06
O.OE-MX)
1.1E-04
9.2E-10
1.9E-07
9.2E-06
7.6E-05
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also included.  Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP):  Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across  the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.       4B-8

-------
                        Table 4B:  Radionuclide  Carcinogenicity  -- Slope Factors'
                                                    (In Units of  Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Lanthanum (57)
Lead (82)






Lutetium(71)
Manganese (25)

Isotope1
Kr-88
Kr-89
Kr-90
La-140
Pb-203
Pb-209f
Pb-210'
Pb-210+D
Pb-211f
Pb-212f
Pb-214f
Lu-177
Mn-52
Mn-54
CASRN"
014995-61-0
016316-03-3
015741-13-6
013981-28-7
014687-25-3
014119-30-3
014255-04-0
014255-04-0(+D)
015816-77-0
015092-94-1
015067-28-4
014265-75-9
014092-99-0
013966-31-9
Radioactive
Half-life"
2.840E+00
3.160E+00
3.230E+01
4.020E+01
5.200E+01
3.250E+00
2.230E+01
2.230E+01
3.610E+01
1.060EH-01
2.680E+01
6.710E+00
5.590E+00
3.130E+02
H
M
S
H
H
H
Y
Y
M
H
M
D
D
D
ICRP
Lung
Class'
*
*
•
W
D
D
D
D
D
D
D
Y
W
W
Gl
Absorption
Factor (f,)9
1.0E+00
1.0E+00
1.0E+00
1.0E-03
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
3.0E-04
1.0E-01
1.0E-01
Ingestion
(Risk/Bq)



6.2E-11
8.6E-12
2.3E-12
1.4E-08
1.8E-08
4.9E-12
1.5E-10
4.6E-12
1.7E-11
5.9E-1 1
3.0E-11
Inhalation
(Risk/Bq)
1.3E-13
7.0E-14
6.5E-14
8.1E-11
7.0E-12
1.9E-12
3.5E-08
1.1E-07
7.6E-11
1.2E-09
7.8E-1 1
5.1E-11
1.0E-10
1.4E-10
External Exposure
(Risk/yr per Bq/g soil)
2.0E-04
1.8E-04
1.1E-04
2.2E-04
1.6E-05
O.OE+00
3.5E-09
4.3E-09
4.3E-06
7.6E-06
1.7E-05
1.8E-06
3.2E-04
7.8E-05
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
" A becquerel (Bq), the Sl.unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also included.  Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+0), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, 0 = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream.  Lung dassifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply  or divide) inhalation or ingestion slope factors. See the  User's Guide for instructions.       4B-9

-------
                       Table 4B:  Radionuclide Carcinogenicity -- Slope Factors'
                                                   (In Units of Becquerels")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)

Mercury (80)

Molybdenum (42)
Neodymium (60)

Neptunium (93)






Nickel (28)
Isotope0
Mn-56
Hg-197
Hg-203
Mo-99
Nd-147
Nd-149
Np-236
Np-237*
Np-237+D
Np-238
Np-239'
Np-240
Np-240m
Ni-59
CASRN"
014681-52-8
013981-51-6
013982-78-0
014119-1S4
014269-74-0
015749-81-2
015700-36-4
013994-20-2
013994-20-2(+D)
015766-25-3
013968-59-7
015690-84-3
015690-84-3(m)
014336-7CW)
Radioactive
Half-life8
2.580E+00
6.410E+01
4.660E+01
6.600E+01
1.100E+01
1.730E+00
1.150E+05
2.140E-I-06
2.140E+06
2.120E+00
2.360E+00
6.500E+01
7.400E+00
7.500E+04
H
H
D
H
D
H
Y
Y
Y
D
D
M
M
Y
ICRP
Lung
Class
W
W
W
Y
Y
Y
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)fl
1.0E-01
2.0E-02
2.0E-02
8.0E-01
3.0E-04
3.0E-04
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
5.0E-02
Ingestion
(Risk/Bq)
1.1E-11
7.3E-12
1.8E-11
4.1E-11
3.5E-11
5.1E-12
6.2E-12
5.9E-09
5.9E-09
3.0E-1 1
2.5E-11
3.5E-12
7.8E-13
2.5E-12
Inhalation
(Risk/Bq)
7.6E-12
1.2E-11
1.3E-10
7.0E-11
1.5E-10
4.3E-12
1.1E-10
7.8E-07
7.8E-07
8.9E-11
4.1E-11
1.8E-12
2.4E-13
1.9E-11
External Exposure
(Risk/yr per Bq/g soil)
1.6E-04
1.5E-06
1.5E-05
1.3E-05
8.1E-06
2.6E-05
2.4E-06
2.1E-07
1.2E-05
4.6E-05
6.2E-06
8.6E-05
2.5E-05
O.OE+00
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D* to indicate that the risks
from radioactive decay chain products are also included.  Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D). half-lives are listed for the parent radionudide.
1 Lung clearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year. W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.      4B-10

-------
                        Table 4B:  Radionuclide  Carcinogenicity  - Slope Factors2
                                                   (In  Units  of  Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Ni-63
Ni-65
Niobium (41) Nb-93m
Nb-94
Nb-95
Nb-95m
Nb-97
Nb-97m
Osmium (76) Os-185
Os-191
Os-191m
Os-193
Palladium (46) Pd-100
Pd-101
CASRN*1
013981-37-8
014833-49-9
007440-03-1 (m)
014681-63-1
013967-76-5
013967-76-5(m)
018496-04-3
018496-04-3(m)
015766-50-4
014119-24-5
014119-24-5(m)
016057-77-5
015690-69-4
015749-54-9
Radioactive
Half-life6
1.000E+02
2.520E+00
1.460E+01
2.030E+04
3.510E+01
8.660E+01
7.210E+01
6.000E+01
9.360E+01
1.540E+01
1.300E+01
3.000E+01
3.640E+00
8.480E+00
Y
H
Y
Y
D
H
M
S
D
D
H
H
D
H
ICRP
Lung
Class'
W
W
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Gl
Absorption
Factor (f,)fl
5.0E-02
5.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
5.0E-03
5.0E-03
Ingestion
(Risk/Bq)
6.5E-12
7.0E-12
4.1E-12
5.7E-1 1
1.8E-11
1.8E-11
3.2E-12
6.5E-14
1.7E-11
1.8E-11
3.2E-12
2.6E-1 1
2.7E-1 1
3.2E-12
Inhalation
(Risk/Bq)
4.9E-11
5.1E-12
5.1E-10
5.7E-09
1.4E-10
4.3E-11
1.9E-12
3.0E-14
2.4E-10
9.7E-11
5.7E-12
3.2E-11
6.2E-11
3.0E-12
External Exposure
(Risk/yr per Bq/g soil)
O.OE+00
5.1E-05
1.4E-09
1.5E-04
7.0E-05
2.2E-06
5.9E-05
6.8E-05
5.9E-05
2.3E-06
9.2E-08
4.6E-06
	

 Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
 A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a *+D" to indicate that the risks
from radioactive decay chain products are also included.  Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
 Lung clearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year,  W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the  User's Guide for instructions.      4B-11

-------
                       Table  4B:  Radionuclide Carcinogenicity -- Slope Factors'
                                                   (In  Units  of Becquerelsb)
JANUARY 1992
Element
(Atomic Number) Isotope0
Pd-103
Pd-107
Pd-109
Phosphorus (15) P-32
P-33
Platinum (78) Pt-191
Pt-193
Pt-193m
Pt-197
Pt-197m
Plutonium (94) Pu-236
Pu-238
Pu-239
Pu-240
CASRN"
014967-68-1
017637-99-9
014981-64-7
014596-37-3
015749-66-3
015706-36-2
015735-70-3
015735-70-3(m)
015735-74-7
015735-74-7(m)
015411-92-4
013981-16-3
015117-48-3
014119-33-6
Radioactive
Half-life6
1.700E+01
6.500E+06
1.350E-I-01
1.430E+01
2.540E+01
2.710E+00
5.000E+01
4.330E+00
1.830E+01
9.440E+01
2.850E+00
8.780E+01
2.410E+04
6.570E+03
D
Y
H
D
D
D
Y
D
H
M
Y
Y
Y
Y
ICRP
Lung
Class'
Y
Y
Y
D
D
D
D
D
D
D
Y
Y
Y
Y
Gl
Absorption
Factor (f,)9
5.0E-03
5.0E-03
5.0E-03
8.0E-01
8.0E-01
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-03
1.0E-03
1.0E-03
1.0E-03
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
5.9E-12
1.2E-12
2.1E-11
9.5E-1 1
1.5E-11
1.0E-11
9.5E-13
1.4E-11
1.3E-11
3.2E-12
1.4E-09
5.9E-09
6.2E-09
6.2E-09
Inhalation
(Risk/Bq)
3.8E-1 1
1.7E-10
2.2E-1 1
8.1E-11
1.2E-11
8.1E-12
2.2E-12
1.1E-11
8.6E-12
2.4E-12
6.5E-07
1.1E-06
1.0E-06
1.0E-06
External Exposure
(Risk/yr per Bq/g soil)
2.0E-08
O.OE+00
5.9E-08
O.OE+00
O.OE+00
1.7E-05
O.OE+00
2.1E-07
8.4E-07
4.3E-06
9.2E-10
7.6E-10
4.6E-10
7.3E-10
8 Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionudide only, except when marked with a VD' to indicate that the risks
from radioactive decay chain products are also included.  Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
' Lung dearance dassification recommended by the International Commission on Radiological Protection (ICRP):  Y = Year,  W = Week, D = Day, * = Gas.
8 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.       4B-12

-------
                        Table  4B:  Radionuclide Carcinogenicity  -- Slope  Factors8
                                                    (In  Units  of Becquerelsb)
JANUARY 1932
Element
(Atomic Number)




Polonium (84)






Potassium (19)

Praseodymium (59)
Isotope6
Pu-241
Pu-242
Pu-243
Pu-244
Po-210r
Po-212f
Po-213t
Po-214f
Po-215f
Po-216f
Po-218'
K-40
K-42
Pr-142
CASRN"
014119-32-5
013982-10-0
015706-37-3
014119-34-7
013981-52-7
015389-34-1
015756-57-7
015735-67-8
015706-52-2
015756-58-8
015422-24-9
013966-00-2
014378-21-3
014191-64-1
Radioactive
Half-life0
1.440E+01
3.760E+05
4.960E+00
8.260E+07
1.380E+02
2.980E-07
4.200E-06
1.640E-04
1.780E-03
1.460E-01
3.050E+00
1.280E+09
1.240E+01
1.910E+01
Y
Y
H
Y
0
S
S
S
S
S
M
Y
H
H
ICRP
Lung
Class'
Y
Y
Y
Y
W
W
W
W
W
W
W
D
D
Y
Gl
Absorption
Factor (f,)g
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E+00
1.0E+00
3.0E-04
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
9.7E-11
5.9E-09
3.0E-12
5.9E-09
4.1E-09
5.9E-22
8.6E-21
2.7E-19
7.6E-18
8.1E-16
7.6E-13
3.0E-10
2.4E-1 1
4.3E-1 1
Inhalation
(Risk/Bq)
6.2E-09
9.7E-07
2.7E-12
9.7E-07
7.0E-08
1.6E-20
2.2E-19
7.6E-18
1.5E-16
1.3E-14
1.6E-11
2.1E-10
3.2E-1 1
4.9E-1 1
External Exposure
(Risk/yr per Bq/g soil)
O.OE+00
6.2E-10
4.9E-07
5.1E-10
7.8E-10
O.OE+00
2.7E-09
7.6E-09
1.2E-08
1.4E-09
O.OE+00
1.5E-05
2.6E-05
5.7E-06
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
" A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionudide only, except when marked with a "+D* to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
0 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
' Lung dearance dassification recommended by the International Commission on Radiological  Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided (or reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.       4B-13

-------
                        Table  4B:  Radionuclide  Carcinogenicity - Slope Factors
                                                    (In Units of  Becquerels")
JANUARY 1982
Element
(Atomic Number)



Promethium (61)



Protactinium (91)



Radium (88)


Isotope0
Pr-143
Pr-144
Pr-144m
Pm-147
Pm-148
Pm-148m
Pm-149
Pa-231'
Pa-233'
Pa-234
Pa-234mT
Ra-223f
Ra-224'
Ra-225*
CASRN"
014981-79-4
014119-05-2
014119-05-2(m)
014380-75-7
014683-19-3
01 4683-1 9-3(m)
015765-31-8
014331-85-2
013981-14-1
015100-28-4
015100-28-4(m)
015623-45-7
013233-32-4
013981-53-8
Radioactive
Half-life"
1.360E+01
1.730E+01
7.200E+00
2.620E+00
5.370E+00
4.130E+01
5.310E+01
3.730E+04
2.700E+01
6.700E+00
1.170E+00
1.140E+01
3.620E+00
1.480E+01
D
M
M
Y
D
D
H
Y
D
H
M
D
D
D
ICRP
Lung
Class'
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
Gl
Absorption
Factor (f,)g
3.0E-04
3.0E-04
3.0E-04
3.0E-04
3.0E-04
3.0E-04
3.0E-04
1.0E-03
1.0E-03
1.0E-03
1.0E-03
2.0E-01
2.0E-01
2.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
3.8E-11
2.6E-12
1.0E-12
8.4E-12
8.4E-1 1
6.8E-11
3.2E-11
2.5E-09
2.7E-11
1.8E-11
1.6E-13
1.7E-09
1.0E-09
1.4E-09
Inhalation
(Risk/Bq)
1.9E-10
9.7E-13
4.3E-13
8.1E-10
2.1E-10
1.3E-09
5.1E-11
9.7E-07
2.3E-10
1.5E-11
4.3E-14
8.4E-08
3.2E-08
4.1E-08
External Exposure
(Risk/yr per Bq/g soil)
8.1E-13
3.2E-06
5.7E-08
1.6E-10
5.1E-05
1.8E-04
8.9E-07
7.0E-07
1.1E-05
1.6E-04
9.7E-07
6.2E-06
6.2E-07
5.1E-08
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq). the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a *+D" to indicate that the risks
from radioactive decay chain products are also included.  Radionudides designated with a T are members of a decay chain.
" Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
8 Radioactive  half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.       4B-14

-------
                        Table  4B:  Radionuclide  Carcinogenicity  - Slope Factors8
                                                    (In Units of  Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)



Radon (66)

Rhodium (45)



Rubidium (37)

Isotope0
Ra-226t
Ra-226+D
Ra-228'
Ra-228+D
Rn-219f
Rn-220f
Rn-222f
Rn-222+D
Rh-103m
Rh-105
Rh-105m
Rh-106
Rb-82
Rb-86
CASRN"
013982-63-3
013982-63-3(+D)
015262-20-1
01 5262-20-1 (+D)
014835-02-0
022481-48-7
014859-67-7
014859-67-7(+D)
007440-1 6-6(m)
014913-89-4
014913-89-4(m)
013967-48-1
014391-63-0
014932-53-7
Radioactive
HalMife*
1.600E+03
1.600E+03
5.750E+00
5.750E+00
3.960E+00
5.560E+01
3.820E+00
3.820E+00
5.610E+01
3.540E+01
4.500E+01
2.990E+01
1.250E+00
1.870E+01
Y
Y
Y
Y
S
S
0
D
M
H
S
S
M
D
ICRP
Lung
Class1
W
W
W
W
*
*
*
•
Y
Y
Y
Y
D
D
Gl
Absorption
Factor (f,)B
2.0E-01
2.0E-01
2.0E-01
2.0E-01
1.0E+00
1.0E+00
1.0E+00
1.0E+00
5.0E-02
5.0E-02
5.0E-02
5.0E-02
1.0E+00
1.0E+00
Ingestion
(Risk/Bq)
3.2E-09
3.2E-09
2.7E-09
2.7E-09

3.8E-11
4.6E-1 1
1.9E-13
1.2E-11
1.7E-14
1.2E-13
3.2E-13
1.6E-10
Inhalation
(Risk/Bq)
8.1E-08
8.1E-08
1.8E-08
1.9E-08
1.2E-12
3.2E-12
2.0E-1 1
2.1E-10
1.1E-13
1.6E-11
9.2E-15
3.2E-14
9.5E-14
1.2E-10
External Exposure
(Risk/yr per Bq/g soil)
3.2E-07
1.6E-04
O.OE+00
7.8E-05
4.3E-06
4.6E-08
3.2E-08
1.6E-04
2.1E-09
5.9E-06
5.9E-07
1.8E-05
9.5E-05
8.9E-06
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D* to indicate that the risks
from  radioactive decay chain products are also included.  Radionudides designated with a f are members of a decay chain.
" Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors.  See the User's Guide for instructions.      4B-1S

-------
                        Table 4B: Radionuclide Carcinogenicity --  Slope  Factors
                                                   (In  Units  of Becquerelsb)
JANUARY 1992
v Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope6
Rb-87
Rb-88
Rb-89
Ruthenium (44) Ru-97
Ru-103
Ru-105
Ru-106
Samarium (62) Sm-147
Sm-151
Sm-153
Scandium (21) Sc-46
Sc-47
Sc-48
Selenium (34) Se-75
CASRN"
013982-13-3
014928-364
014191-65-2
015758-35-7
013968-53-1
014331-95-4
013967-48-1
014392-33-7
015715-94-3
015766XXM
013967-63-0
014391-96-9
014391-86-7
014265-71-5
Radioactive
Half-life"
4.730E+10
1.780E+01
1.540E+01
2.900E+00
3.940E+01
4.440E+00
3.680E+02
1.060E+11
9.000E+01
4.670E+01
8.380E+01
3.420E+00
4.370E+01
1.200E+02
Y
M
M
D
D
H
D
Y
Y
H
D
D
H
D
ICRP
Lung
Class'
D
D
D
Y
Y
Y
Y
W
W
W
Y
Y
Y
W
Gl
Absorption
Factor (f,)9
1.0E+00
1.0E+00
1.0E+00
5.0E-02
5.0E-02
5.0E-02
5.0E-02
3.0E-04
3.0E-04
3.0E-04
1.0E-04
1.0E-04
1.0E-04
8.0E-01
Ingestion
(Risk/Bq)
9.2E-11
4.6E-12
2.5E-12
4.6E-12
2.4E-1 1
1.0E-11
2.6E-10
4.3E-10
3.0E-12
2.4E-1 1
4.3E-1 1
1.7E-11
5.1E-11
1.6E-10
Inhalation
(Risk/Bq)
6.5E-1 1
2.1E-12
1.1E-12
7.0E-12
2.3E-10
8.9E-12
1.2E-08
1.9E-07
2.4E-10
3.5E-1 1
7.3E-10
3.2E-1 1
6.2E-1 1
1.6E-10
External Exposure
(Risk/yr per Bq/g soil)
O.OE+00
6.5E-05
2.0E-04
1.1E-05
4.1E-05
7.0E-05
O.OE+00
O.OE+00
1.1E-11
1.2E-06
1.9E-04
6.2E-06
3.2E-04
2.2E-05
" Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a *f are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
9 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.      4B-16

-------
                     Table 4B: Radionuclide Carcinogenicity --  Slope  Factors'
                                              (In Units of Becquerels")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0












Silicon (14) Si-31
Silver (47) Ag-105
Ag-108
Ag-108m
Ag-109m
Ag-110
Ag-110m
Ag-111
Sodium (11) Na-22
Na-24
Strontium (38) Sr-82
Sr-85
Sr-85m
Sr-89
CASRN"
014276-49-4
014928-14-4
014391-65-2
014391-65-2(m)
014378-38-2(m)
014391-76-5
014391 -76-5(m)
0157690-04-0
013966-32-0
013982-04-2
014809-50-8
013967-73-2
013967-73-2(m)
014158-27-1
Radioactive
Half-life0
1.570E-1-02
4.130E+01
2.370E+00
1.270E+02
3.960E+01
2.460E+01
2.500E+02
7.460E+00
2.600E+00
1.500E+01
2.500E-I-01
6.480E+01
6.770E+01
5.060E-H01
M
D
M
Y
S
S
D
D
Y
H
D
D
M
D
ICRP
Lung
Class'
W
Y
Y
Y
Y
Y
Y
Y
D
D
D
D
D
D
Gl
Absorption
Factor (f,)9
1.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
1.0E-I-00
1.0E+00
3.0E-01
3.0E-01
3.0E-01
3.0E-01
Ingestion
(Risk/Bq)
5.9E-12
2.0E-1 1
2.3E-13
9.5E-11
8.9E-15
8.1E-14
1.3E-10
4.3E-1 1
1.8E-10
2.7E-1 1
2.0E-10
2.1E-11
3.2E-13
8.1E-11
Inhalation
(Risk/Bq)
4.6E-12
1.1E-10
6.5E-14
4.1E-09
2.4E-15
2.2E-14
1.9E-09
1.3E-10
1.3E-10
2.6E-1 1
1.9E-10
2.7E-1 1
1.6E-13
7.8E-11
External Exposure
(Risk/yr per Bq/g soiO
8.1E-08
1.4E-06
1.4E-04
3.5E-08
2.7E-06
2.5E-04
2.1E-06
1.9E-04
4.3E-04
3.5E-09
3.8E-05
1.3E-05
1.3E-08
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
" A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq • 27 pCI.
c For each radionudide listed, corresponding slope factors are the risks per unit Intake or exposure for that radionuclide only, except when marked with a % D" to Indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
Or*f4'ir\^r*ti\ta holfJifa* Q — C^w-snrtrl M _ Mirtirttf* H _ Hot* V _ VA**«> CA» U«A/.A *++*£*. MiMi:*Jjt*» i»M* Am+n\t n«w4< i ***«•> / . F\\ hotf IIWAO 4m lietfvJ fnr #Ka no rant ror4i/ini i/-lirta
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent
1 Lung clearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.      4B-17

-------
                       Table  4B:  Radionuclide Carcinogenicity --  Slope Factors8
                                                   (In Units of Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per UnR Intake or Exposure
Element
(Atomic Number)




Sulfur (16)
Tantalum (73)
Technetium (43)







lsotopec
Sr-90'
Sr-90+D
Sr-91
Sr-92
S-35
Ta-182
Tc-95
Tc-95m
Tc-96
Tc-96m
Tc-97
Tc-97m
Tc-99
Tc-99m
CASRN"
010098-97-2
010098-97-2(+D)
014331-91-0
014928-29-1
015117-53-0
013982-00-8
014809-56-4
014809-56-4(m)
014808-44-7
014808-44-7(m)
015759-35-0
015759-35-0(m)
014133-76-7
014133-76-7(m)
Radioactive
Half-life*
2.860E+01
2.860E+01
9.500E+00
2.710E+00
8.740E+01
1.150E-I-02
2.000E+01
6.100E+01
4.280E+00
5.150E+01
2.600E+06
8.900E+01
2.130E+05
6.020E+00
Y
Y
H
H
D
D
H
D
D
M
Y
0
Y
H
ICRP
Lung
Class1
D
D
D
0
D
Y
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)8
3.0E-01
3.0E-01
3.0E-01
3.0E-01
8.0E-01
1.0E-03
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
Ingestion
(Risk/Bq)
8.9E-10
9.7E-10
2.3E-11
1.5E-11
5.9E-12
4.6E-1 1
1.5E-12
4.9E-11
4.9E-1 1
6.2E-13
4.1E-12
3.0E-1 1
3.5E-11
1.4E-12
Inhalation
(Risk/Bq)
1.5E-09
1.7E-09
1.9E-11
1.2E-11
5.1E-12
1.2E-09
6.2E-13
1.1E-10
5.7E-11
5.7E-13
2.6E-11
1.4E-10
2.2E-10
7.3E-13
External Exposure
(Risk/yr per Bq/g soil)
O.OE+00
O.OE+00
6.5E-05
1.2E-04
O.OE+00
1.1E-04
6.5E-05
5.1E-05
2.2E-04
1.9E-06
9.5E-09
1.0E-08
1.6E-11
6.2E-06
 Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
 A becquerel (Bq). the SI unit of activity, is equal to one nudear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit Intake or exposure for that radionudide only, except when marked with a VD" to Indicate that the risks
from radioactive decay chain products are also induced.  Radionudides designated with a "f are members of a decay chain.
 Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and eadi chain member.
" Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
 Lung clearance classification recommended by the International Commission  on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e.. multiply or divide) inhalation or ingestion slope factors. See the  User's Guide for instructions.      4B-18

-------
                        Table  4B:  Radionuclide  Carcinogenicity -  Slope  Factors'
                                                    (In  Units of  Becquerelsb)
JANUARY 1992
Element
(Atomic Number)
Tellurium (52)






Terbium (65)
Thallium (81)



Isotope'
Te-125m
Te-127
Te-127m
Te-129
Te-129m
Te-131
Te-131m
Te-132
Tb-158
Tb-160
Tl-202
71-204
^-207*
TI-208T
CASRN"
014390-73-9(m)
013981-49-2
013981-49-2(m)
014269-71-7
01 4269-71 -7(m)
014683-12-6
01 4683-1 2-6(m)
014234-28-7
015759-55-4
013981-29-8
015720-57-7
013968-51-9
014133-67-6
014913-50-9
Radioactive
Half-life"
5.800E+01
9.350E+00
1.090E+02
6.960E+01
3.360E+01
2.500E+01
3.000E+01
7.820E+01
1.500E+02
7.230E+01
1.220E+01
3.780E+00
4.770E+00
3.050E-t-00
D
H
D
M
D
M
H
H
Y
D
D
Y
M
M
ICRP
Lung
Class'
W
W
W
W
W
W
W
W
W
W
D
D
D
D
Gl
Absorption
Factor (f,)fl
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
3.0E-04
3.0E-04
1.0E+00
1.0E-I-00
1.0E+00
1.0E+00
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
2.3E-1 1
6.2E-12
5.9E-11
3.0E-12
8.6E-11
7.6E-12
1.0E-10
8.1E-11
3.2E-11
4.9E-11
2.3E-1 1
4.6E-11
3.5E-13
4.9E-13
Inhalation
(Risk/Bq)
1.5E-10
6.2E-12
4.3E-10
1.8E-12
5.4E-10
3.8E-12
1.5E-10
1.4E-10
2.5E-09
5.1E-10
1.6E-11
3.5E-1 1
1.2E-13
1.4E-13
External Exposure
(Risk/yr per Bq/g soil)
7.0E-08
3.8E-07
2.3E-08
3.5E-06
1.7E-06
3.2E-05
1.3E-04
1.1E-05
9.7E-05
3.5E-05
2.4E-08
2.0E-07
3.5E-04
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionudide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also included.  Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second. M = Minute, D = Day. Y = Year.  For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year. W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount  of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the  User's Guide for instructions.      4B-19

-------
                        Table  4B:  Radionuclide Carcinogenicity -- Slope  Factors'
                                                    (In  Units  of Becquerels")
JANUARY 1992
Element
(Atomic Number) Isotope0
11-209*
Thorium (90) 171-227*
Th-228f
Th-228+D
171-229*
Th-229+D
Th-230*
Th-231*
Th-232*
171-234*
Thulium (69) Tm-1 70
Tm-171
Tin (50) Sn-113
Sn-121
CASRN*
015690-73-0
015623-47-9
014274-82-9
014274-82-9(+D)
015594-54-4
015594-54-4(+D)
014269-63-7
014932-40-2
2007440-29-1
015065-10-8
013981-30-1
014333-45-0
013966-06-8
014683-06-8
Radioactive
Half-life*
2.200E+00
1.870E+01
1.910E+00
1.910E+00
7.340E+03
7.340E+03
7.700E+04
2.550E+01
1.410E+10
2.410E+01
1.290E+02
1.920E+00
1.150E+02
2.710E+01
M
D
Y
Y
Y
Y
Y
H
Y
D
D
Y
D
H
ICRP
Lung
Class'
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
W
Gl
Absorption
Factor (f,)9
1.0E+00
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
3.0E-04
3.0E-04
2.0E-02
2.0E-02
Slope Factor
Lifeline Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
3.8E-13
1.2E-10
3.0E-10
1.5E-09
5.7E-10
2.4E-09
3.5E-10
1.1E-11
3.2E-10
1.1E-10
4.1E-11
3.2E-12
2.4E-1 1
7.3E-12
Inhalation
(Risk/Bq)
1.2E-13
1.3E-07
2.1E-06
2.1E-06
2.0E-06
2.1E-06
7.8E-07
1.3E-11
7.6E-07
8.6E-10
5.7E-10
8.4E-1 1
2.5E-10
8.6E-12
External Exposure
(Risk/yr per Bq/g soil)
1.9E-04
4.3E-06
1.5E-08
1.5E-04
1.8E-05
1.5E-09
6.2E-08
7.0E-10
9.5E-08
1.0E-07
8.9E-09
8.9E-08

a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a VD" to indicate that the risks
from radioactive decay chain products are also included.  Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second. M = Minute, D = Day, Y = Year.  For those radionudides with decay products (+D), half-lives are listed tor the parent radionuclide.
' Lung clearance dassification recommended by the International Commission on Radiological  Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream.  Lung dassifications and Gl absorption values
are provided (or reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.      4B-20

-------
                        Table 4B: Radionuclide  Carcinogenicity - Slope  Factors'
                                                     (In Units of  Becquerels")
JANUARY 19B2
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Sn-121m
Sn-125
Sn-126
Tungsten (74) W-181
W-185
W-187
Uranium (92) U-232
U-233
U-234'
U-235'
U-235+D
U-236
U-237
U-238f
CASRN11
014683-06-8(m)
014683-08-0
015832-50-5
015749-46-9
014932-41-3
014983-48-3
014158-29-3
013968-55-3
013966-29-5
015117-96-1
01 511 7-96-1 (+D)
013982-70-2
014269-75-1
007440-61-1
Radioactive
Half-life*
5.550E+01
9.640E+00
1.000E+05
1.210E+02
7.510E+01
2.380E+01
7.200E+01
1.590E+05
2.450E+05
7.040E+08
7.040E-I-08
2.340E+07
6.750E+00
4.470E+09
Y
0
Y
D
0
H
Y
Y
Y
Y
Y
Y
0
Y
ICRP
Lung
Class'
W
W
W
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Gl
Absorption
Factor (f,)8
2.0E-02
2.0E-02
2.0E-02
3.0E-01
3.0E-01
3.0E-01
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
Ingestion
(Risk/Bq)
1.5E-11
9.7E-11
1.5E-10
2.2E-12
1.3E-11
1.7E-11
1.0E-09
4.3E-10
4.3E-10
4.3E-10
4.3E-10
4.1E-10
2.4E-1 1
4.3E-10
Inhalation
(Risk/Bq)
2.5E-10
3.2E-10
2.1E-09
1.7E-12
8.1E-12
1.1E-11
1.6E-06
7.3E-07
7.0E-07
6.8E-07
6.8E-07
6.8E-07
7.0E-1 1
6.5E-07
External Exposure
(Risk/yr per Bq/g soil)
	
3.0E-05
8.9E-07
5.9E-07
1.3E-09
4.1E-05
1.2E-09
1.1E-09
8.1E-10
6.5E-06
6.5E-06
6.5E-10
3.5E-06
5.7E-10
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens.  For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq • 27 pCi.
c For each radionudide listed, corresponding slope factors are trie risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the risks
from  radioactive decay chain products are also included.  Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year.  For those radionuclides with decay products (+D), half-lives are listed for (tie parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream.  Lung classifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.      4B-21

-------
                        Table  4B:  Radionuclide  Carcinogenicity -  Slope  Factors'
                                                    (In  Units  of Becquerelsb)
JANUARY 19G2
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
U-238+D
U-240
Vanadium (23) V-48
Xenon (54) Xe-122
Xe-123
Xe-125
Xe-127
Xe-129m
Xe-131m
Xe-133
Xe-133m
Xe-135
Xe-135m
Xe-137
CASRN*
007440-61-1 (+D)
015687-53-3
014331-97-6
015151-09-4
01 5700-1 0-4
013994-18-8
013994-19-9
013965-99-6(m)
014683-1 1-5(m)
014932-42-4
014932-42-4(m)
014995-62-1
014995-62-1(m)
014835-21-3
ICRP
Radioactive Lung
Half-life" . Class'
4.470E+09
1.410E+01
1.600E+01
2.010E+01
2.140E+00
1.680E+01
3.640E+01
8.890E-fOO
1.180E+01
5.250E+00
2.190E+00
9.110E+00
1.540E-f01
3.830E+00
Y Y
H Y
D W
H
H
H
D
D
D
D
D
H
M
M
Gl
Absorption Ingestion
Factor (f,)9 (Risk/Bq)
5.0E-02 7.6E-10
5.0E-02 3.2E-1 1
1.0E-02 5.9E-11
1 OF 1 00 	
1 OEiOO
1 OFiOO 	
1 nFion
1 flF.ifin 	 	
1 QFiOO 	
1 OFiflft
i fiFinn
1 fiFiHO
1 HFifln
1 OF 4 00

Inhalation
(Risk/Bq)
1.4E-06
3.2E-1 1
2.1E-10
8.9E-14
2.0E-14
1.1E-14
1.1E-14
1.6E-14
1.2E-14
1.2E-14
1.5E-14
2.2E-14
5.7E-15
4.9E-14
External Exposure
(Risk/yr per Bq/g soil)
9.7E-07
4.1E-09
2.7E-04
2.3E-06
4.6E-05
1.3E-05
1.4E-05
3.5E-07
1.2E-07
6.2E-07
8.9E-07
1.7E-05
3.5E-05
1.6E-05
a Calculated by the EPA Office of Radiation Programs (ORP).  EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq « 27 pCI.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionudide only, except when marked with a VD" to indicate that the risks
from radioactive decay chain products are also included.  Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only.  Do not use these factors to adjust (i.e., multiply or divide) inhalation or  ingestion slope factors. See the User's Guide for instructions.       4B-22

-------
                        Table 4B: Radionuclide Carcinogenicity  - Slope Factors'
                                                   (In  Units  of  Becquerels")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Xe-138
Yttrium (39) Y-90T
Y-91
Y-91m
Y-92
Y-93
Zinc (30) 2n-65
Zn-69
Zn-69m
Zirconium (40) Zr-93
Zr-95
Zr-97
CASRN"
015751-81-2
010098-91-6
014234-24-3
014234-24-3(m)
015751-59-4
014981-70-5
013982-39-3
013982-23-5
013982-23-5(m)
015751-77-6
013967-71-0
014928-30-4
Radioactive
Half-life"
1.410E+01
6.410E+01
5.850E+01
4.970E+01
3.540E+00
1.010E+01
2.440E+02
5.560E+01
1.380E+01
1.530E+06
6.400E+01
1.690E-I-01
M
H
D
M
H
H
D
M
H
Y
D
H
ICRP
Lung
Class'
•
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
Gl
Absorption
Factor (f,)fl
1.0E+00
1.0E-04
1.0E-04
1.0E-04
1.0E-04
1.0E-04
5.0E-01
5.0E-01
5.0E-01
2.0E-03
2.0E-03
2.0E-03
Ingestion
(Risk/Bq)

8.6E-1 1
7.6E-11
5.9E-13
1.9E-11
3.8E-1 1
2.3E-10
1.5E-12
1.2E-11
4.6E-12
2.7E-1 1
6.5E-1 1
Inhalation
(Risk/Bq)
7.6E-14
1.5E-10
1.3E-09
9.5E-13
1.6E-11
3.8E-11
4.3E-10
8.6E-13
1.5E-11
1.8E-10
2.7E-10
6.8E-11
External Exposure
(Risk/yr per Bq/g soil)
1.1E-04
O.OE+00
3.2E-07
4.6E-05
2.3E-05
8.1E-06
5.4E-05
4.9E-10
3.5E-05
O.OE+00
6.8E-05
1.6E-05
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also inducted. Radionudides designated with a 'f are members of a decay chain.
d Chemical Abstract Service Reference Number.  For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day. Y = Year. For those radionudides with decay products (+D), half-lives are listed for the  parent radionudide.
'  Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day,  * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided (or reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.      4B-23

-------
                                   REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


ACENAPHTHENE                    000083-32-9
        010165  US  EPA. 1989. MOUSE ORAL SUBCHRONIC STUDY  WITH ACENAPHTHENE.  STUDY CONDUCTED BY  HAZELTON LABORATORIES,  INC., FOR THE  OFFICE OF SOLID
                WASTE AND EMERGENCY RESPONSE, WASHINGTON,  DC.

ACENAPTHYLENE                   000208-96-8
        005202  US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ACENAPHTHYLENE.  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
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ACEPHATE                          030560-19-1
        005833  CHEVRON CHEMICAL COMPANY. 1987. CONFIDENTIAL BUSINESS INFORMATION UNPUBLISHED DATA. MRID NO. 40504819

                US  EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACEPHATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
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ACETONE                           000067-64-1
        005204  US  EPA. 1986. NINETY-DAY GAVAGE STUDY IN ALBINO  RATS USING ACETONE. OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE, WASHINGTON,
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                US  EPA. 1988. UPDATED HEALTH EFFECTS ASSESSMENT  FOR ACETONE.  PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT,
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ACETONE  CYANOHYDRIN           000075-86-5
        005776  HOWARD, JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS  OF  FOOD TREATED WITH HYDROGEN CYANIDE.  J AGRIC FOOD CHEM 3:325-329.
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                US  EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ACETONE CYANOHYDRIN.  PREPARED BY THE OFFICE  OF HEALTH AND
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                US  EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  CYANOHYDRINS. PREPARED BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL
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ACETONITRILE                    000075-05-8
        005210  NATIONAL TOXICOLOGY PROGRAM (NTP). 1983. 90-DAY  SUBCHRONIC TOXICITY STUDIES OF ACETONOTRILE IN RATS  AND MICE. REPORT  TO
                NATIONAL TOXICILOGY PROGRAM.

                US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ACETONITRILE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.



                                                                                                                                           R1-1

-------
                                    REFERENCES FOR  HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY
                                                          (OTHER  THAN  CARCINOGENICITY)                                      January 1992


ACETOPHENONE                    000098-86-2
        005212  HAGAN.  EC, WH HANSEN, OG FITZHUGH, ET AL. 1967. FOOD  FLAVORINGS AND COMPOUNDS OF RELATED STRUCTURE.   II.  SUBACUTE AND
                CHRONIC TOXICITY. FOOD COSMET. TOXICOL. 5(2): 141-157.

ACROLEIN                         000107-02-8
        010390  NEWELL  GW.   1958.  ACUTE AND  SUBACUTE TOXICITY OF ACROLEIN.  STANFORD RESEARCH INSTITUTE.  SRI PROJECT NO. 5-868-2.
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              •  US EPA.   1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR ACROLEIN.   PREPARED BY THE OFFICE OF  HEALTH  AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINATI, OH FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

        010429  FERON VJ, A  KRUYSSE, HP TIL,  HR  IMMEL. 1978. REPEATED EXPOSURE TO ACROLEIN VAPOR: SUBACUTE STUDIES IN HAMSTERS, RATS AND
                RABBITS.  TPXICOLOGY 9:47-57.

                KUTZMAN,  RS. 1981. A SUBCHRONIC  INHALATION STUDY OF FISCHER  344 RATS EXPOSED TO 0, 0.4, 1.4 OR 4.0 PPM ACROLEIN. BROOKHAVEN
                NATIONAL  LABORATORY, UPTON, NY,  NATIONAL TOXICOLOGY PROGRAM. INTERAGENCY AGREEMENT NO. 222-401-65-90043.

ACRYLAMIDE                       000079-06-1
        005835  BUREK JD, RR ALBEE, JE BEYER, ET AL. 1980. SUBCHRONIC TOXICITY OF ACRYLAMIDE ADMINISTERED TO RATS  IN  THE  DRINKING WATER
                FOLLOWED  BY  UP TO 144 DAYS OF RECOVERY. J ENVIRON PATHOL  TOXICOL. 4: 157-182.

                US EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR ACRYLAMIDE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

ACRYLIC  ACID                    000079-10-7
        005836  DEPASS  LR, MD WOODS IDE, RH GARMAN AND CS WEIL. 1983.  SUBCHRONIC AND REPRODUCTIVE TOXICOLOGY STUDIES ON ACRYLIC ACID IN
                DRINKING  WATER OF THE RAT. DRUG  CHEM TOXICOL. 6(1): 1-20.

                US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR ACRYLIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

        010346  MILLER,  RR,  JA AYERS, GC JERSEY  AND MJ MCKENNA. 1981. INHALATION TOXICITY OF ACRYLIC ACID. FUND APPL  TOXICOL. 1(3):271-277.

                MILLER,  RR,  JA AYRES, GC JERSEY. 1979. ACRYLIC ACID 90-DAY VAPOR INHALATION  STUDY WITH RATS AND MICE. FINAL REPORT #79 RC-
                1024. TOXICOLOGY RESEARCH LABORATORY, HEALTH AND ENVIRONMENTAL SCIENCE, DOW  CHEMICAL COMPANY, MIDLAND MI.

ADIPONITRILE                    000111-69-3
        005157  US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  ADIPONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.
                                                                                                                                            R1-2

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                                   REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


ALACHLOR                         015972-60-8
        005837  MONSANTO COMPANY. 1984. CONFIDENTIAL BUSINESS  INFORMATION, UNPUBLISHED STUDY.  ACCESSION NO. 255953. MRID NO. OOH8923.

                US  EPA. 1984. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR ALACHLOR. PREPARED  BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE  OFFICE OF SOLID  WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

ALDICARB                         000116-06-3
        010433  RHONE-POULENC AG COMPANY, 1988. MRID NO. 40695901. UNPUBLISHED STUDY.

                US  EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR ALDICARB.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF DRINKING WATER, WASHINGTON DC.

ALDRIN                            000309-00-2
        005159  FITZHUGH, OG, AA NELSON AND ML QUAIFE. 1964. CHRONIC ORAL  TOXICITY OF ALDRIN AND  DIELDRIN IN RATS AND DOGS. FOOD COSMET.
                TOXICOL. 2: 551-562.

                US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ALDRIN. PREPARED  BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,  WASHINGTON, DC.

ALLIDOCHLOR                     000093-71-0
        005838  US  EPA. 1984. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR ALLIDOCHLOR. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID  WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

ALLYL  ALCOHOL                   000107-18-6
        005839  CARPANINI FMB, IF GAUNT,  J HARDY, ET AL. 1978. SHORT-TERM  TOXICITY OF ALLYL ALCOHOL IN RATS. TOXICOLOGY. 9: 29-45.

                US  EPA. 1985. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR ALLYL ALCOHOL. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND
                EMERGENCY RESPONSE,  WASHINGTON, DC

ALLYL  CHLORIDE                 000107-05-1
        010369  BOQUIN, L, D SHUWEI, Y AIRU, .ET AL.  1982. STUDIES ON THE TOXICITY OF ALLYL CHLORIDE. ECOTOXICOL ENVIRON SAF 6:19-27.

                US  EPA. 1986. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR ALLYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE  OFFICE OF SOLID  WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

ALUMINUM                         007429-90-5
        005162  US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ALUMINUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.



                                                                                                                                           R1-3

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                                   REFERENCES FOR  HEAST TABLE  1:  SUBCHRONIC  AND CHRONIC TOXICITY
                                                         (OTHER  THAN CARCINOGENICITY)                                     January 1992


ALUMINUM PHOSPHIDE            020859-73-8
        010255  HACKENBURG U.  1972. CHRONIC INGESTION BY RATS OF STANDARD DIET TREATED  WITH ALUMINUM PHOSPHIDE. TOXICOL APPL PHARMACOL.
                23(1): 147-158.

AMETRYN                           000834-12-8
        005841   CIBA-GEIGY CORPORATION. 1961. CONFIDENTIAL BUSINESS INFORMATION,  UNPUBLISHED STUDY.  MRID NO. 00034843.

                US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMETRYN.  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

AMINO-2-NAPHTHOL,  1-          002834-92-6
        005842  US EPA. 1986.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1- AMINO-2-NAPHTOL AND 1-AMINO-2-NAPHTOL HYDROCHLORIDE. PREPARED
                BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE
                OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

AMINO-2-NAPHTHOL HYDROCHLORIDE, 1-        001198-27-2
        005843  US EPA. 1986.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1- AMINO-2-NAPHTOL AND 1-AMINO-2-NAPHTOL HYDROCHLORIDE. PREPARED
                BY THE OFFICE  OF  HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE
                OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

AMINOPHENOL, M-                 000591-27-5
        005844  RE TA, RF LOEHR,  SC RODRIGUEZ, ET AL. 1984. RESULTS OF TERATOGENICITY TESTING OF M-AMINOPHENOL IN SPRAGUE-DAWLEY RATS. FUND
                APPL TOXICOL.  4(1): 98-104.

                US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMINOPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

AMINOPHENOL, 0-                 000095-55-6
        005845  US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMINOPHENOLS.  PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

AMINOPHENOL, P-                 000123-30-8
        005846  US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR AMINOPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY
                RESPONSE, WASHINGTON, DC.
                                                                                                                                          R1-4

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                                    REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC  AND CHRONIC  TOXICITY
                                                          (OTHER THAN  CARCINOGENICITY)                                      January 1992


AMINOPYRIDINE,  4-             000504-24-5
        005847  KOHN FE.  1968.  FOUR-WEEK SUBACUTE ORAL  TOXICITY OF COMPOUND  1861  HYDROCHLORIOE -- ALBINO RATS.  (UNPUBLISHED STUDY).  PREPARED
                BY INDUSTRIAL BIOTEST LABORATORIES,  INC. UNDER 224-12. SUBMITTED  BY  PHILLIPS PETROLEUM CO., BARTLESVILLE, OK. CDL: 229844-E.

                US EPA.  1980. 4-AMINOPYRIDINE. AVITROL  PESTICIDE REGISTRATION  STANDARD. PREPARED BY THE OFFICE  OF PESTICIDE PROGRAMS, US EPA,
                WASHINGTON, DC. NTIS PB84-209907

                US EPA.  1989.   HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4- AMINOPYRIDINE. PREPARED BY THE  OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
                WASHINGTON, DC.

AMMONIA                           007664-41-7
        005166  CAMPBELL,  CL, RK OAWES, S DEOLALKAR  AND MC MERRITT. 1958.  EFFECT  OF  CERTAIN CHEMICALS IN WATER  ON THE FLAVOR OF BREWED
                COFFEE.  FOOD RES.  23: 575-579. CITED  IN US EPA, 1981.

                WHO (WORLD HEALTH ORGANIZATION). 1986.  ENVIRONMENTAL HEALTH  CRITERIA. 54. AMMONIA. WHO, GENEVA, SWITZERLAND.

                US EPA.  1981. AMBIENT WATER QUALITY  CRITERION FOR THE PROTECTION  OF  HUMAN HEALTH:  AMMONIA. PREPARED BY THE OFFICE OF HEALTH
                AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR  THE OFFICE OF WATER
                REGULATIONS AND STANDARDS, WASHINGTON,  DC.

                US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR AMMONIA. PREPARED  BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR  THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.

        010392  HOLNESS  DL, JT  PURDHAM AND JR NETHERCOTT.  1989.  ACUTE AND  CHRONIC  RESPIRATORY EFFECTS OF OCCUPATIONAL EXPOSURE TO  AMMONIA.
                AM IND  HYG ASSOC J.  50: 646-650.

                BRODERSON, JR,  JR LINDSAY AND JE CRAWFORD.  1976.  THE ROLE  OF ENVIRONMENTAL AMMONIA IN RESPIRATORY MYCOPLASMOSIS OF RATS.
                AM J PATHOL 85: 115-130.

ANILINE                           000062-53-3
        010370  OBERST  FW, E HACKLEY, C COMSTOCK. 1956. CHRONIC TOXICITY OF  ANILINE  VAPOR (5PPM) BY INHALATION. ARCH IND HEALTH 13:379-384.

                US EPA.  1985. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR ANILINE.  PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,  WASHINGTON, DC.

ANTHRACENE                       000120-12-7
        010166  US EPA.  1989. SUBCHRONIC TOXICITY IN MICE WITH ANTHRACENE. FINAL  REPORT. HAZELTON LABORATORIES  AMERICA, INC. PREPARED FOR
                THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON,  DC.

                US EPA.  1987. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR ANTHRACENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,  WASHINGTON, DC.


                                                                                                                                             R1-5

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                                   REFERENCES  FOR HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                       January 1992


ANTIMONY  (METALLIC)           007440-36-0
        005170  SCHROEDER, HA, M MITCHENER AND AP NASON. 1970.  ZIRCONIUM, NIOBIUM, ANTIMONY AND LEAD  IN RATS: LIFE-TIME STUDIES. J. NUTR.
                100: 59-66.

                US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

                US  EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR ANTIMONY OXIDES. PREPARED  BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

ANTIMONY  PENTOXIDE            001314-60-9
        005174  SCHROEDER, HA, M MITCHENER AND AP NASON. 1970.  ZIRCONIUM, NIOBIUM, ANTIMONY AND LEAD  IN RATS: LIFE-TIME STUDIES. J. NUTR.
                100: 59-66.

                US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

                US  EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR ANTIMONY OXIDES. PREPARED  BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

ANTIMONY  POTASSIUM TARTRATE          000304-61-0
        005234  SCHROEDER, HA, M MITCHENER AND AP NASON. 1970.  ZIRCONIUM, NIOBIUM, ANTIMONY AND LEAD  IN RATS: LIFE-TIME STUDIES. J. NUTR.
                100: 59-69.


                US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

                US  EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR ANTIMONY OXIDES. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.
                                                                                                                                           R1-6

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                                    REFERENCES  FOR HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC  TOXICITY
                                                          (OTHER THAN  CARCINOGENICITY)                                       January  1992


ANTIMONY TETROXIDE             001332-81-6
        005238  SCHROEDER,  HA, H KITCHENER AND AP NASON.  1970. ZIRCONIUM, NIOBIUM, ANTIMONY AND LEAD IN  RATS:  LIFE-TIME STUDIES.  J. NUTR.
                100:  59-69.

                US EPA.  1987. HEALTH  EFFECTS ASSESSMENT  FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL
                RESPONSE, WASHINGTON, DC.

                US EPA.  1985. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES. PREPARED BY  THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON. DC.

ANTIMONY TRIOXIDE              001309-64-4
        005242  SCHROEDER,  HA, M MITCHENER AND AP NASON.  1970. ZIRCONIUM, NIOBIUM, ANTIMONY AND LEAD IN  RATS:  LIFE-TIME STUDIES.  J. NUTR.
                100:59-69.

                US EPA.  1987. HEALTH  EFFECTS ASSESSMENT  FOR ANTIMONY AND COMPOUNDS. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL
                RESPONSE, WASHINGTON, DC.

                US EPA.  1985. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR ANTIMONY OXIDES. PREPARED BY  THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON. DC.

ARAMITE                            000140-57-8
        005849  OSER  BL,  M  OSER. 1962. 2-
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                                   REFERENCES FOR HEAST TABLE  1: SUBCHRONIC  AND CHRONIC  TOXICITY
                                                          (OTHER  THAN CARCINOGENICITY)                                      January 1992


ARSENIC,  INORGANIC            007440-38-2
        010434  TSENG, WP. 1977. EFFECTS AND DOSE-RESPONSE RELATIONSHIPS OF SKIN CANCER AND BLACKFOOT DISEASE  WITH ARSENIC. ENVIRON.  HEALTH
                PERSPECT.  19:109-119.

                TSENG, UP, HM CHU, SU HOU,  JM  FONG, CS LIN, S YEH.  1968. PREVALENCE OF SKIN CANCER IN AN ENDEMIC AREA OF CHRONIC ARSENICISM N
                TAIWAN.  J. NATL. CANCER INST.  40: 453-463.

ATRAZINE                          001912-24-9
        010435  C1BA-GEIGY CORPORATION.  1987.  CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO.  40431301.

                US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ATRAEINE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

BARIUM                            007440-39-3
        010348  WONES, RG, BL STADLER,  LA FROHMAN. 1990. LACK OF EFFECT OF DRINKING WATER BARIUM ON CARDIOVASCULAR RISK FACTOR.  ENVIRON
                HEALTH PERSPECT. 85:1-13

                BRENNIMAN, GR, PS LEVY. 1984.  HIGH BARIUM LEVELS IN PUBLIC DRINKING WATER AND ITS ASSOCIATION  WITH ELEVATED BLOOD PRESSURE.
                IN:  ADVANCES  IN MODERN  TOXICOLOGY  IX, EJ CALABRESE, ED. PRINCETON SCIENTIFIC  PUBLICATIONS, PRINCETON, NJ. P 231-249.

                US EPA.  1985. DRINKING  WATER CRITERIA DOCUMENT FOR  BARIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA  AND  ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF DRINKING WATER,  WASHINGTON, DC. EXT REVIEW
                DRAFT. FINAL DRAFT (ON  PUBLIC  COMMENT). NTIS PB 86-118031/AS.

BARIUM  CYANIDE                 000542-62-1
        010393  WONES, RG, BL STADLER,  LA FROHMAN. 1990. LACK OF EFFECT OF DRINKING WATER BARIUM ON CARDIOVASCULAR RISK FACTOR.  ENVIRON
                HEALTH PERSPECT. 85:1-13

                BRENNIMAN, GR, PS LEVY. 1984.  HIGH BARIUM LEVELS IN PUBLIC DRINKING WATER AND ITS ASSOCIATION  WITH ELEVATED BLOOD PRESSURE.
                IN:  ADVANCES  IN MODERN  TOXICOLOGY  IX, EJ CALABRESE, ED. PRINCETON SCIENTIFIC  PUBLICATIONS, PRINCETON, NJ. P 231-249.

                US EPA.  1985. DRINKING  WATER CRITERIA DOCUMENT FOR  BARIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF DRINKING WATER,  WASHINGTON, DC. EXT REVIEW
                DRAFT. FINAL DRAFT (ON  PUBLIC  COMMENT). NTIS PB 86-118031/AS.

BENEFIN                          001861-40-1
        005852  ELI  LILLY  AND CO. 1972.  CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO. 00037678.

                US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS.PROFILE FOR BENEFIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,  WASHINGTON,  DC.
                                                                                                                                            R1-8

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                                   REFERENCES  FOR  HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                         (OTHER  THAN  CARCINOGENICITY)                                      January 1992


BENZAL CHLORIDE                000098-87-3
        005853  US  EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZAL CHLORIDE. PREPARED  BY THE OFFICE  OF  HEALTH AND
                ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON,  DC.

BENZALDEHYDE                    000100-52-7
        005854  KLUUE WM, CA MONTGOMERY, HD GILES AND  JD PREJEAU.  1983. ENCEPHALOPATHY  IN RATS AND  NEPHROPATHY IN RATS  AND MICE AFTER
                SUBCHRONIC ORAL EXPOSURE TO BENZALDEHYDE. FOOD CHEM TOXICOL. 21(3):  245-250.

                US  EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZALDEHYDE. PREPARED  BY  THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON,  DC.

BENZALDEHYDE CYANOHYDRIN     000532-28-5
        005781  US  EPA. 1988.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS. PREPARED  BY  THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

BENZIDINE                        000092-87-5
        005830  LITTLEFIELD, NA, CJ NELSON AND CH FRITH. 1983. BENZIDINE DIHYDROCHLORIDE: TOXICOLOGICAL ASSESSMENTS  IN  MICE DURING CHRONIC
                EXPOSURE. J. TOXICOL. ENVIRON. HEALTH. 12:671-68.

BENZOIC  ACID                    000065-85-0
        005260  FDA (FOOD AND  DRUG ADMINISTRATION).  1973. EVALUATION  OF THE HEALTH ASPECTS OF BENZOIC  ACID AND SODIUM BENZOATE AS FOOD
                INGREDIENTS. DHEW, WASHINGTON, DC. REPORT NO. SCOGS-7 NTIS PB-223 837/6. P. 17.

                US  EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BENZOIC ACID. PREPARED  BY  THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

BENZYL ALCOHOL                 000100-51-6
        005855  NTP (NATIONAL  TOXICOLOGY PROGRAM). 1988. TOXICOLOGY AND CARCINOGENESIS  STUDIES OF BENZYL ALCOHOL (CAS NO  100-51-6) IN F344/N
                RATS AND B6C3F1 MICE  (GAVAGE STUDIES). NTP TECHNICAL  REPORT, NTP TR 343. P 1-161.

        005856  US  EPA. 1989.   HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BENZYL  ALCOHOL. PREPARED  BY THE OFFICE  OF  HEALTH AND
                ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON,  DC.

BERYLLIUM                        007440-41-7
        005262  SCHROEDER, HA  AND M MITCHNER. 1975.  LIFE-TERM STUDIES IN RATS: EFFECTS  OF ALUMINUM,  BARIUM, BERYLLIUM AND TUNGSTEN.  J NUTR.
                105:421-427.
                                                                                                                                         R1-9

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January  1992


BIPHENYL,  1,1'-                000092-52-4
        005857  AMBROSE AM,  AN  BOOTH, F DE EDS AND AJ COS JR.  1960. A TOXICOLOGICAL STUDY OF BIPHENYL, A CITRUS FUNGISTAT. FOOD RES.
               25:328-336.

               US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1,1'-  BIPHENYL. PREPARED BY THE OFFICE  OF  HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE  OF SOLID WASTE  AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

BIS(2-CHLOROISOPROPYL)  ETHER           039638-32-9
        010257  MITSUMORI K, T  USUI, K TAKAHASHI, AND Y SHIRASU.  1979. TWENTY-FOUR MONTH CHRONIC TOXICITY STUDIES OF DICHLORODIISOPROPYL
               ETHER IN MICE.  NIPPON NOYAKU GAKKAISHI. 4(3) 323-335.

BIS(2-ETHYLHEXYL)PHTHALATE           000117-81-7
        005612  CARPENTER, CP,  CS WEIL AND HF SMYTH. 1953. CHRONIC ORAL TOXICITY OF DK2-ETHYLHEXYL) PHTHALATE FOR  RATS, GUINEA PIGS  AND
               DOGS. ARCH IND  HYG OCC MED  8: 219-226.

BISPHENOL  A                     000080-05-7
        005266  NTP (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENESIS BIOASSAY OF BISPHENOL A IN  F344 RATS AND B6C3F1 MICE (FEED STUDY).
               NTP TECH REP SER. NO. 80-35 NTIS PB 84-1555308 P. 192.

               US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BISPHENOL- A. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

BORON, ELEMENTAL              007440-42-8
        005272  WEIR, RJ, JR AND RS FISHER. 1972. TOXICOLOGIC STUDIES ON BORAX AND BORIC ACID.  TOXICOL APPL PHARMACOL  23(3):351-364.

               US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR BORON AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE  OFFICE OF  EMERGENCY AND REMEDIAL  RESPONSE,
               WASHINGTON,  DC.

        005269  GARABRANT DH, L BERNSTEIN, JM PETERS ET AL.  1985.  RESPIRATORY EFFECTS OF BORAX DUST.  BR J IND MED.  42: 831-837.

               US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BORON  AND BORON COMPOUNDS. PREPARED BY  THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE  OF SOLID WASTE  AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

BORON  TRIFLUORIDE             007637-07-2
        010395  RUSCH GM, GM HOFFMAN, RF MCCONNELL ET AL.  1986.  INHALATION TOXICITY STUDIES WITH  BORON TRIFLUORIDE.  TOXICOL APPL
               PHARMACOL. 83:  69-78.

               US EPA.  1991.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BORON AND BORON COMPOUNDS.  PREPARED  BY  THE OFFICE OF HEALTH
               AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE
               AND EMERGENCY RESPONSE, WASHINGTON, DC.



                                                                                                                                        R1-10

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                                   REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January  1992


BROMINATED  DIBENZO-P-DIOXINS
        005859 US EPA. 1985.  HEALTH  AND ENVIRONMENTAL  EFFECTS PROFILE FOR  BROMINATED DIBENZO-P-DIOXINS. PREPARED BY THE OFFICE  OF HEALTH
               AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON. DC.

               US EPA. 1985.  HEALTH  AND ENVIRONMENTAL  EFFECTS PROFILE FOR  BROMINATED DIBENZOFURANS. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON. DC.

BROMINATED  DIBENZOFURANS
        005859 US EPA. 1985.  HEALTH  AND ENVIRONMENTAL  EFFECTS PROFILE FOR  BROMINATED DIBENZOFURANS. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

               US EPA. 1985.  HEALTH  AND ENVIRONMENTAL  EFFECTS PROFILE FOR  BROMINATED DIBENZO-P-DIOXINS. PREPARED BY THE OFFICE  OF HEALTH
               AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON. DC.

BROMOACETONE        .             000598-31-2
        005860 US EPA. 1986.  HEALTH  AND ENVIRONMENTAL  EFFECTS PROFILE FOR  BROMOACETONE.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

BROMOCHLOROETHANES
        005861  US EPA. 1985.  HEALTH  AND ENVIRONMENTAL  EFFECTS PROFILE FOR  BROMOCHLOROETHANES. PREPARED BY THE OFFICE OF HEALTH  AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

BROMODICHLOROMETHANE          000075-27-4
        005718 NTP (NATIONAL TOXICOLOGY PROGRAM).  1986.  TOXICOLOGY AND CARCINOGENESIS STUDIES OF BROMODICHLOROMETHANE IN F344/N  RATS AND
               B6C3F1 MICE (GAVAGE  STUDIES). NTP TECH REPORT, SER NO 321, NIH PUBL NO 87-2537.

        005715 US EPA. 1987. HEALTH EFFECTS ASSESSMENT  FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON, DC.

BROMODIPHENYL ETHER,  P-      000101-55-3
        005864 US EPA. 1986.  HEALTH  AND ENVIRONMENTAL  EFFECTS PROFILE FOR  4- BROMOPHENYL PHENYL ETHER. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.
                                                                                                                                         R1-11

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                                    REFERENCES  FOR HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY
                                                          (OTHER THAN  CARCINOGENICITY)                                       January 1992


BROMOFORM                        000075-25-2
        005722  NTP (NATIONAL TOXICOLOGY PROGRAM).  1989.  TOXICOLOGY AND CARCINOGENICITY  STUDIES OF TRIBROMOMETHANE AND  BROMOFORM IN F344 RATS
                AND B6C3F1 MICE (GAVAGE STUDIES).  NTP-350.

                US EPA.  1989. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR BROMOFORM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

                US EPA.  1987. HEALTH AND ENVIRONMENTAL  ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  EMERGENCY AND
                REMEDIAL RESPONSE, WASHINGTON,  DC.

BROMOMETHANE                    000074-83-9
        005862  DANSE  LH, FL VAN VELSEN AND CA VAN  DER  HEIJDEN.  1984. METHYL BROMIDE: CARCINOGENIC EFFECTS IN THE RAT FORESTOMACH. TOXICOL
                APPL PHARMACOL. 72: 262-271.

                US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR BROMOMETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,  DC.

                US EPA.  1986. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR METHYL BROMIDE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

        005863  RUSSO  JM, WK ANGER, JV SETZER AND  WS BR1GHTWELL. 1984. NEUROBEHAVIORAL ASSESSMENT OF CHRONIC LOW-LEVEL  METHYL BROMIDE
                EXPOSURE IN THE RABBIT. J TOXICOL  ENVIRON HEALTH. 14: 247-255.

        905863  REUZEL,  PGJ, CF KUPER, HC DREEF-VAN DER MEULEN AND VMM HOLLANDERS. 1987.  CHRONIC (29-MONTH) INHALATION  TOXICITY AND CARCINOGENICITY
                STUDY  OF METHYL BROMIDE IN RATS.   REPORT  NO. V86.469/221044. NETHERLANDS ORGANIZATION FOR APPLIED SCIENTIFIC RESEARCH, DIVISION  FOR
                NUTRITION AND FOOD RESERACH, TNO.   EPA/OTS DOCUMENT #86-8700001202.

                REUZEL,  PGH, HC DREEF-VAN DER MEULEN, VMM HOLLANDERS, CF KUPER, VJ FERON, CA VAN DER HEIJDEN. 1991. CHRONIC INHALTION TOXICITY AND
                CARCINOGENICITY STUDY OF METHYL BROMIDE IN WISTAR RATS.  FOOD CHEM. TOXICOL.  (29(1): 31-39.

BROMOPHOS                        002104-96-3
        005865  LEUSCHNER F, A LEUSCHNER AND E POPPE. 1967. CHRONISCHER REPRODUKTIONSVERSUCH UBER 3 GENERATIONEN AN WISTAR-RATTEN 8EI
                FORTDAUERNER VERABREICHUNG VON BROMOPHOS. REPORT CH BOEHRINGER SOHN. (UNPUBLISHED).
                      o

                US EPA.  1986.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR BROMOPHOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY
                RESPONSE, WASHINGTON, DC.
                                                                                                                                            R1-12

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC  TOXICITY
                                                          (OTHER  THAN  CARCINOGENICITY)                                      January 1992


BROMOXYNIL                       001689-84-5
        005866  UNION  CARBIDE AGRICULTURE PRODUCTS, INC. 1982.  CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED  STUDY. MRID NO.  00096521.

                US EPA.  1984.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOXYNIL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

BROMOXYNIL  OCTANOATE         001689-99-2
        005867  UNION  CARBIDE AGRICULTURE PRODUCTS, INC. 1982.  CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED  STUDY. MRID NO.  00096521.

                US EPA.  1984. HEALTH AND  ENVIRONMENTAL EFFECTS  PROFILE FOR BROMOXYNIL OCTANOATE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR  THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

BUSAN  77                          031512-74-0
        005868  US EPA.  1984.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR BUSAN 77. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

BUSAN  90                          002491-38-5
        005869  US EPA.  1984.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR BUSAN 90. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

BUTANOL,  1-                     000071-36-3
        005870  US EPA.  1986. BUTANOL: RAT ORAL SUBCHRONIC TOXICITY STUDY. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

                US EPA.  1989.  HEALTH  AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1- BUTANOL.  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

BUTYL  BENZYL  PHTHALATE,  N-          000085-68-7
        005616  NTP (NATIONAL TOXICOLOGY  PROGRAM). 1985. PROJECT NO 12307-02,  - 03.  HAZELTON LABORATORIES AMERICA, INC, UNPUBLISHED STUDY.

                US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED  PHTHALIC ACID ESTERS. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

                US EPA.  1991. DRINKING WATER CRITERIA DOCUMENT  FOR PHTHALIC ACID ESTERS (PAE)S. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR  THE OFFICE OF DRINKING WATER,
                WASHINGTON, DC.

                US EPA.  1989. HEALTH AND  ENVIRONMENTAL EFFECTS  DOCUMENT FOR BUTYL BENZYL  PHTHALATE. PREPARED BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR  THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

                                                                                                                                          R1-13

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                                   REFERENCES FOR  HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


BUTYLATE                         002008-41-5
        005871   STAUFFER CHEMICAL COMPANY. 1987.  CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO.  40289101.

                US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  BUTYLATE. PREPARED  BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

BUTYLCHLORIDE,t-              000507-20-0
        005810   US EPA. 1988.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  MONOCHLOROBUTANES.  PREPARED BY THE OFFICE OF HEALTH AND
             .   ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

BUTYROLACTONE,  GAMMA-        000096-48-0
        005872   US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  BUTYROLACTONE, GAMMA. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

CACODYLIC ACID                 000075-60-5
        005873   NEES PO. 1968. REPORT ON CACODYLIC ACID TOXICITY TO ANIMALS. WISCONSIN ALUMNI RES FOUND. EPA PESTICIDE PETITION NO OF0911.

                US EPA. 1989.   HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CACODYLIC ACID. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

CADMIUM                          007440-43-9
        005280   US EPA. 1985.  DRINKING WATER CRITERIA DOCUMENT ON CADMIUM. OFFICE  OF DRINKING WATER, WASHINGTON, DC. FINAL DRAFT.

                US EPA. 1980.  AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CADMIUM. PREPARED BY  THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS,
                WASHINGTON,  DC. EPA-440/5-80-025.

CALCIUM CYANIDE               000592-01-8
        010258   HOWARD JW AND  RF HANZAL. 1955.  CHRONIC TOXICITY FOR RATS OF  FOOD TREATED WITH HYDROGEN CYANIDE.  AGRIC FOOD CHEM. 3: 325-329.

                PHILBRICK DJ,  JB HOPKINS, DC HILL, JC ALEXANDER AND RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING
                IN RATS. J TOXICOL ENVIRON HEALTH. 5: 579-592.
                                                                                                                                         R1-U

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                                    REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                          (OTHER THAN  CARCINOGENICITY)                                       January  1992


CAPROLACTAM                     000105-60-2
        005282  POWERS,  WJJ, JC PECKHAM, KM SI I NO AND  SC GAD. 1984. EFFECTS  OF  SUBCHRONIC DIETARY CAPROLACTUM ON RENAL FUNCTION. PROC SYMP
                IND APPROACH CHEM RISK ASSESSMENT.  CAPROLACTAM RELAT COMPD CASE STUDY 77-96 IND HEALTH  FOUND, PITTSBURGH,  PA.

                US EPA.  1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  CAPROLACTAM. PREPARED BY  THE OFFICE OF HEALTH  AND  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

        005284  SEROTA,  DG, AM HOBERMAN AND SC  GAD.  1984. A THREE GENERATION REPRODUCTION STUDY WITH  CAPROLACTAM IN RATS.  PROC SYMP IND
                APPROACH CHEM RISK ASSESSMENT:  CAPROLACTAM RELAT COMPD CASE  STUDY  191-204 IND,  HEALTH FOUND  PITTSBURGH, PA.

                US EPA.  1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  CAPROLACTAM. PREPARED BY  THE OFFICE OF HEALTH  AND  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

CAPTAFOL                         002425-06-1
        005874  ORTHO-CHEVRON CHEMICAL COMPANY.  1985.  CONFIDENTIAL BUSINESS  INFORMATION, UNPUBLISHED  STUDY. ACCESSION NO 260671, MRID NO.
                00149488, 00155196.

                US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  CAPTAFOL. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

CAPTAN                            000133-06-2
        005875  CHEVRON  CHEMICAL COMPANY. 1982.  CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED  STUDY. MRID NO. 00125293.

                STAUFFER CHEMICAL COMPANY. 1982  CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED  STUDY. MRID NO. 00120315

                US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  CAPTAN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

CARBARYL                         000063-25-2
        005876  CARPENTER CP, CW WEIL, PE POLIN,  ET  AL. 1961. MAMMALIAN TOXICITY OF 1-NAPHTHYL-N-METHYLCARBAMATE (SEVIN INSECTICIDE). J AGRIC
                FOOD CHEM. 9: 30-39.

                US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  CARBARYL.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE. WASHINGTON, DC.
                                                                                                                                           R1-15

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


CARBOFURAN                      001563-66-2
        005877  FMC CORPORATION.  1983. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 250740-250755. MRID NO.  00129507.

               US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBOFURAN.  PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE,  WASHINGTON, DC.

CARBON DISULFIDE              000075-15-0
        010259  HARDIN BD, GP  BOND, MR SIKOR,  FD ANDREW, RP BELILES AND RW NIEMEIR.  1981. TESTING OF SELECTED WORKPLACE CHEMICALS  FOR
               TERATOGENIC POTENTIAL. SCAND J WORK ENVIRON HEALTH. 7CSUPPL 4):  66-75.

        010430  TABACOVA S,  LA HINKOVA, L BALABAEVA. 1978.  CARBON DISULFIDE TERATOGENICITY AND  POSTNATAL EFFECTS IN RATS. TOXICOL  LETT
               2(3):129-133.

               TABACOVA S,  B  NIKIFOROV, L BALABAEVA. 1983. CARBON DISULFIDE INTRAUTERINE SENSITIZATION. J APPL TOXICOL 3(5): 233-239.

               US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBON  DISULFIDE. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
               WASHINGTON,  DC.

CARBON MONOXIDE                000630-08-0
        910430  REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL  AMBIENT AIR QUALITY STANDARDS.

CARBON TETRACHLORIDE         000056-23-5
        005288  BRUCKNER,  JV,  WF  MACKENZIE, S MURALIDHARA,  ET AL. 1986. ORAL TOXICITY OF CARBON TETRACHLORIDE: ACUTE, SUBACUTE AND
               SUBCHRONIC STUDIES  IN RATS. FUND APPL TOXICOL 6<1):16-34.

CHLORAL                          000075-87-6
        005290  SANDERS, VM, BM KAUFFMANN, KL WHITE, JR. 1982. TOXICOLOGY OF CHLORAL HYDRATE IN THE MOUSE. ENVIRON  HEALTH PERSPECT
               44:146-173.

               US EPA. 1988.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORAL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE,  WASHINGTON, DC.

CHLORDANE                       000057-74-9
        005296  VELSICOL CHEMICAL CORP. 1983. ACC  NO 252267, MRID NO. 00138591,  00144313. AVAILABLE FROM EPA UNDER  FOI.

CHLORINE  CYANIDE              000506-77-4
        010261  HOWARD JW AND  RF  HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.

               PHILBRICK DJ,  JB  HOPKINS, DC HILL, JC ALEXANDER AND RG THOMSON.  1979. EFFECTS OF PROLONGED CYANIDE  AND THIOCYANATE FEEDING
               IN RATS. J TOXICOL  ENVIRON HEALTH. 5: 579-592.



                                                                                                                                        R1-16

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                     January 1992


CHLORO-M-CRESOL,  P-           000059-50-7
        005366 MADSEN, C, PH ANDERSEN, 0 MEYER  AND G UURTZEN.  1986. 4-CHLORO-E-METHYLPHENOL:  SALMONELLA/MAMMALIAN-MICROSOME MUTAGENICITY
               TEST AND SUBACUTE TOXICITY TEST  IN RATS. BULL ENVIRON CONTAM TOXICOL 37(5):651-654.

               US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR  P-CHLORO-M-CRESOL. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

CHLORO-1.3-BUTADIENE,  2-           000126-99-8
        REFER  TO REFERENCES FOR  HEAST TABLE 2.

CHLOROACETALDEHYDE             000107-20-0
        005342 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR  CHLOROACETALDEHYDE.  PREPARED BY THE OFFICE OF  HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

CHLOROACETIC  ACID              000079-11-8
        005346 IRDC (INTERNATIONAL RESEARCH AND DEVELOPMENT CORPORATION).  1982. SUBCHRONIC  ORAL TOXICITY TEST WITH MONOCHLOROACETIC ACID IN
               RATS. NATIONAL TOXICOLOGY PROGRAM, BETHESDA, MD P 1-101.

               US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR  CHLOROACETIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
              ' ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE,
               WASHINGTON, DC.

CHLOROANILINE,  2-              000095-51-2
        005347 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR  CHLOROANILINES.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

CHLOROANILINE,  3-              000108-42-9
        005348 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR  CHLOROANILINES.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

CHLOROANILINE,  4-              000106-47-8
        005349 NCI (NATIONAL CANCER  INSTITUTE). 1979. BIOASSAY OF P-CHLOROANILINE FOR POSSIBLE CARCINOGENICITY. NCI CARC.  TECH. REP. SER.
               NO. 189. NTIS PB-295896.

               US EPA. 1987. HEALTH AND ENVIRONMETNAL EFFECTS  DOCUMENT FOR  CHLOROANILINES.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.
                                                                                                                                        R1-17

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                                   REFERENCES FOR  HEAST  TABLE  1: SUBCHRONIC  AND CHRONIC  TOXICITY
                                                         (OTHER  THAN  CARCINOGENICITY)                                      January 1992


CHLOROBENZENE                   000108-90-7
        005354  MONSANTO COMPANY.   1967.  13-WEEK ORAL ADMINISTRATION—DOGS. MONOCHLOROBENZENES. FINAL REPORT. PROJECT NO.  241-105.
               FEBRUARY 24.  PREPARED BY HAZELTON LABORATORIES.

               KNAPP, WK, UM BUSEY, AND W KUNDZINS.  1971. SUBACUTE ORAL TOXICITY OF MONOCHLOROBENZINE IN DOGS AND RATS.  TOXICOL. APPL. PHARMACOL.
               19: 393 (ABSTRACT).

               US EPA. 1985. HEALTH ASSESSMENT DOCUMENT  FOR CHLORINATED BENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH. EPA 600/8-84-015F.NTIS PB85-150332.

               US EPA. 1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHOLOROBENZENE. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
               ASSESSMENT,ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON, DC.

CHLOROBENZILATE                 000510-15-6
        010260  CIBA-GEIGY CORPORATION. 1984. MRID NO 00144691.

CHLOROBENZOIC ACID, P-       000074-11-3
        005360  KIECKEBUSCH,  W,  W  GRIEM AND K LANG.  1960. THE TOLERABILITY OF P- CHLOROBENZOIC ACID. ARZNEIMI  HEL-FORSCH  10:999-10001.

               US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR  P-CHLOROBENZOIC ACID. PREPARED BY  THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

CHLOROBENZOTRIFLUORIDE, 4-           000098-56-6
        005364  HOOKER CHEMICAL  CORP. 1981. MODIFIED 90-DAY GAVAGE AND REPRODUCTION STUDY  IN RATS PCBTF.  CONDUCTED BY ELARS BIORESEARCH
               LABORATORIES, INC,  FORT COLLINS, CO, US EPA/OPTS PUBLIC  FILES. MICROFICHE  #OTS0508148.

               US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR  4- CHLOR08ENZOTRIFLUORIDE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

CHLOROBUTANE, 1-               000109-69-3
        005806  NTP (NATIONAL TOXICOLOGY PROGRAM), 1986.  TOXICOLOGY AND  CARCINOGENESIS STUDIES OF N-BUTYL CHLORIDE IN F344/N RATS AND

        005808  B6C3F1 MICE (GAVAGE STUDIES). CAS NO  109-69-3. NTP-TR-312,  198 P.

               US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR  MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

CHLOROBUTANE, 2-               000078-86-4
        005809  US EPA. 1988. HEALTH  AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR  MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

                                                                                                                                         R1-18

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                                   REFERENCES  FOR  HEAST  TABLE  1: SUBCHRONIC  AND CHRONIC TOXICITY
                                                         (OTHER  THAN  CARCINOGENICITY)                                     January 1992


CHLOROCYCLOPENTADIENE        041851-50-7
        005297  US EPA. 1987. HEALTH  AND ENVIRONMETNAL  EFFECTS DOCUMENT  FOR  CHLORINATED  CYCLOPENTADIENES.  PREPARED BY THE OFFICE OF HEALTH  AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

CHLOROFORM                       000067-66-3
        005372  HEYWOOD, R, RJ SORTUELL, PRB NOEL ET AL.  1979. SAFETY EVALUATION OF TOOTHPASTE CONTAINING  CHLOROFORM. III.  LONG-TERM STUDY  IN
                BEAGLE DOGS. J. ENVIRON. PATHOL. TOXICOL. 2: 835-851.

CHLOROMETHANE                   000074-87-3
        010005  US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR  METHYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

CHLORONITROBENZENE,   M-          000121-73-3
        005879  US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR  CHLORONITROBENZENES. PREPARED  BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

CHLOROPHENOL, 2-               000095-57-8
        010436  EXON, JH, LD KOELLER. 1982. EFFECTS  OF  TRANSPLACENTAL EXPOSURE TO CHLORINATED PHENOLS. ENVIRON HEALTH PERSPECT 46:137-140.

                US EPA. 1987. HEALTH  EFFECTS ASSESSMENT FOR 2-CHLOROPHENOL AND 2,4- DICHLOROPHENOL. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  EMERGENCY AND
                REMEDIAL RESPONSE, WASHINGTON, DC.

                US EPA. 1987. HEALTH  AND ENVIRONMENTAL  EFFECTS DOCUMENT  FOR  CHLORINATED  PHENOLS. PREPARED  BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

                US EPA. 1990. HEALTH  AND ENVIRONMENTAL  EFFECTS DOCUMENT  FOR  2- CHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY
                RESPONSE, WASHINGTON, DC.

CHLOROPHENOL, 3-               000108-43-0
        005309  US EPA. 1987. HEALTH  AND ENVIRONMENTAL  EFFECTS DOCUMENT  FOR  CHLORINATED  PHENOLS. PREPARED  BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

CHLOROPHENOL, 4-               000106-48-9
        005310  US EPA. 1987. HEALTH  AND ENVIRONMENTAL  EFFECTS DOCUMENT  FOR  CHLORINATED  PHENOLS. PREPARED  BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE. WASHINGTON, DC.



                                                                                                                                         R1-19

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                                   REFERENCES FOR HEAST  TABLE  1: SUBCHRONIC  AND CHRONIC TOXICITY
                                                        (OTHER  THAN  CARCINOGENICITY)                                     January 1992


CHLOROPROPANE,  2-             000075-29-6
        010444  GAGE, JC.  1970. THE SUBACUTE  INHALATION TOXICITY OF 109 INDUSTRIAL CHEMICALS. BRJ INO MED 27(1):1-18.

               US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  2-CHLOROPROPANE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF  SOLID WASTE  AND
               EMERGENCY  RESPONSE, WASHINGTON, DC.

CHLOROTOLUENE,  M-             000108-41-8
        005880  US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  CHLOROTOLUENES. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF  SOLID WASTE  AND
               EMERGENCY  RESPONSE, WASHINGTON, DC.

CHLOROTOLUENE,  0-             000095-49-8
        010167  GIBSON, WR,  FO GOSSETT,  GR KOEN1G, F MARROQUIN. 1974. THE  TOXICITY OF DAILY ORAL DOSES OF 0-CHLOROTOLUENE IN THE RAT.
               TOXICOLOGY DIVISION, LILLY RESEARCH LABORATORIES.  SUBMITTED  TO TEST RULES DEVELOPMENT BRANCH, OFFICE OF TOXIC SUBSTANCES,
               US EPA, WASHINGTON, DC.

CHLOROTOLUENE,  P-             000106-43-4
        010200  US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  CHLOROTOLUENES. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF  SOLID WASTE  AND
               EMERGENCY  RESPONSE, WASHINGTON, DC.

CHLORPYRIFOS                    002921-88-2
        005881  DOW CHEMICAL COMPANY. 1972. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 112118.

               US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  CHLORPYRIFOS AND CHLOROPYRIFOS-METHYL. PREPARED BY THE OFFICE OF
               HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID
               WASTE AND  EMERGENCY RESPONSE, WASHINGTON, DC.

CHLORPYRIFOS  METHYL          005598-13-0
        005882  US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  CHLORPYRIFOS AND CHLORPYRIFOS-METHYL. PREPARED BY THE OFFICE OF
               HEALTH AND  ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  SOLID
               WASTE AND  EMERGENCY RESPONSE, WASHINGTON, DC.

CHLORTHALONIL                  001897-45-6
        005883  DIAMOND SHAMROCK CHEMICAL COMPANY. 1970. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION  NO 111253, MRID NO.
               00057702,  00114034.
                                                                                                                                       R1-20

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                                   REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC  AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


CHLORTHIOPHOS                   060238-56-4
        005884  WORTHING CR AND SB WALKER, ED. 1983. THE PESTICIDE MANUAL, 7TH ED. BRITISH  CROP PROTECTION  COUNCIL, THE LAVENHAM PRESS LTD.
                SUFFOLK, ENGLAND.  P 130.

                US  EPA. 1986.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE  FOR  CHLORTHIOPHOS.  PREPARED BY THE  OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

CHROMIUM (III)                  016065-83-1
        005731  IVANKOVIC, S AND R PREUSSMAN. 1975.  ABSENCE OF TOXIC AND CARCINOGENIC EFFECTS AFTER ADMINISTRATIONS OF HIGH DOSES OF CHROMIC
                OXIDE PIGMENT IN SUBACUTE AND LONG-TERM  FEEDING EXPERIMENTS  IN RATS.  FOOD COSMET TOXICOL 13: 347-351.

                US  EPA. 1984. HEALTH EFFECTS ASSESSMENT  FOR TRIVALENT CHROMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

CHROMIUM (VI)                   018540-29-9
        005522  MACKENZIE, RD, RU  BYERRUM, CF DECKER ET  AL. 1958. CHRONIC TOXICITY STUDIES, II.  HEXAVALENT AND TRIVALENT CHROMIUM
                ADMINISTERED IN DRINKING WATER TO RATS.  AM MED ASSOC ARCH IND HEALTH   18: 232-234.

                US  EPA. 1984. HEALTH EFFECTS ASSESSMENT  FOR HEXAVALENT CHROMIUM. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

CHRYSENE                         000218-01-9
        005885  US  EPA. 1984.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE  FOR  CHRYSENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

COPPER                            007440-50-8
        005374  US  EPA. 1987. DRINKING WATER CRITERIA DOCUMENT FOR COPPER. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE  OFFICE OF DRINKING WATER, WASHINGTON, DC.

COPPER CYANIDE                 000544-92-3
        010262  US  EPA. 1986. 90 DAY ORAL TOXICITY STUDY OF COPPER CYANIDE.  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

CRESOL,  M-                       000108-39-4
        005380  US  EPA. 1986. 0,M,P-CRESOL. 90-DAY ORAL  SUBCHRONIC TOXICITY  STUDIES IN RATS. OFFICE OF SOLID WASTE, WASHINGTON, DC.

                US  EPA. 1987. 0,M,P-CRESOL. 90-DAY ORAL  SUBCHRONIC NEUROTOXICITY STUDY IN RATS. OFFICE OF SOLID WASTE, WASHINGTON, DC.
                                                                                                                                         R1-21

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                                   REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


CRESOL,  0-                       000095-48-7
        005384  US  EPA. 1986. 0,«,P-CRESOL. 90-DAY ORAL SUBCHRONIC TOXICITY  STUDIES  IN RATS. OFFICE OF SOLID WASTE,  WASHINGTON, DC.

                US  EPA. 1987. 0,M,P-CRESOL. 90-DAY ORAL SUBCHRONIC NEUROTOXICITY  STUDY IN RATS.  OFFICE OF SOLID WASTE, WASHINGTON, DC.

CRESOL,  P-                       000106-44-5
        005388  US  EPA. 1986. 0,M,P-CRESOL. 90-DAY ORAL SUBCHRONIC TOXICITY  STUDIES  IN RATS. OFFICE OF SOLID WASTE,  WASHINGTON, DC.

                US  EPA. 1987. 0,M,P-CRESOL. 90-DAY ORAL SUBCHRONIC NEUROTOXICITY  STUDY IN RATS.  OFFICE OF SOLID WASTE, WASHINGTON, DC.

CUMENE                            000098-82-8
        005392  WOLF, MA, VK ROWE,  00  MCCOLLISTER, RL HOLLINGSWORTH AND F  OYEN. 1956. TOXICOLOGICAL STUDIES OF CERTAIN ALKYLATED BENZENE AND
                BENZENES. AHA ARCH  IND HEALTH  14:387-398.

                US  EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  CUMENE.  PREPARED BY  THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

        005908  MONSANTO COMPANY.  1986. ONE MONTH STUDY OF  CUMENE VAPOR ADMINISTERED TO MALE AND FEMALE SPRAGUE-DAWLEY RATS BY INHALATION.  US
                EPA/OTS PUBLIC FILES,  80 SUBMISSION. MICROFICHE  # OTS 0513229.

                US  EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  CUMENE.  PREPARED BY  THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

CYANAZINE                        021725-46-2
        010411  E.I. DU PONT DE NEMOURS AND COMPANY, INC.   1986.  CONFIDENTIAL BUSINESS INFORMATION,  UNPUBLISHED STUDY.   MRID NO. 40081901
                AND 40229001.

                US  EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYANAZINE.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

CYANIDE  (CN-)                   000057-12-5
        005396  HOWARD, JW AND RF  HANZAL.  1955. CHRONIC TOXICITY FOR RATS  OF FOOD TREATED WITH HYDROGEN CYANIDE. J AGRIC  FOOD CHEM 3:325-329.


                US  EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR CYANIDE. PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR  THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.

CYANOGEN                         000460-19-5
        010263  HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY  FOR RATS OF  FOOD  TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.
                                                                                                                                          R1-22

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                                   REFERENCES FOR  HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                         (OTHER  THAN  CARCINOGENICITY)                                      January  1992


CYANOGEN  BROMIDE               000506-68-3
        010264  HOWARD JU AND RF  HANZAL; 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE.  AGRIC  FOOD CHEM. 3:  325-329.

CYCLOATE                          001134-23-2
        005886  US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYCLOATE. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

CYCLOHEXANOL                    000108-93-0
        005887  US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYCLOHEXANOL. PREPARED  BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

CYCLOHEXYLAMINE                000108-91-8
        005398  GAUNT, IF, M SHARRATT, PG GRASSO,  AB LANSDOWN AND SD  GANGOLLI. 1974. SHORT-TERM TOXICITY OF CYCLOHEXYLAMINE HCL IN THE RAT.
                FOOD COSMET TOXICOL   12:609-624.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOHEXYLAMINE. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

        005400  GAUNT, IF, J HARDY, P GRASSO, SD  GANGOLLI AND KR BUTTERWORTH.  1976.  LONG-TERM TOXICITY OF CYCLOHEXYLAMINE HYDROCHLORIDE IN
                THE RAT. FOOD COSMET TOXICOL 14(4):255-268.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOHEXYLAMINE. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

CYCLOPENTADIENE                000542-92-7
        REFER  TO REFERENCES FOR HEAST TABLE 2.

DACTHAL                             001861-32-1
        005888  DIAMOND SHAMROCK  AGRICULTURAL CHEMICALS.  1963. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO. 00083584.

                US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DACTHAL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC
                                                                                                                                        R1-23

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                                   REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


DALAPON                           000075-99-0
        005889  PAYNTER OE, TU TUSING, DD MCCOLLISTER AND  VK ROUE. 1960.  TOXICOLOGY OF DALAPON  SODIUM (2,2-DICHLOROPROPIONIC ACID, SODIUM
                SALT). J AGRIC FOOD  CHEM. 8: 47-51.

                US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  DALAPON. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

DDT                                000050-29-3
        005408  LAUG, EP, AA NELSON, OG FITZHUGH AND FM KUNZE. 1950. LIVER CELL ALTERATION AND  DDT STORAGE IN THE FAT OF THE RAT INDUCED BY
                DIETARY LEVELS OF  1-50 PPM DDT. J PHARMACOL EXP THERAP  98:268-273.

DECABROMODIPHENYL  ETHER      001163-19-5
        005891  KOCIBA RJ, LO FRAUSON CG HUMISTON, ET AL.  1975. RESULTS OF A TWO- YEAR DIETARY  FEEDING STUDY WITH DECABROMODIPHENYL OXIDE
                (DCDPO) IN RATS. COMBUST TOXICOL. 2(4): 267-285.

                NORRIS JM, JW EHRMANTRAUT, CL GIBBONS, ET  AL. 1975. TOXICOLOGY OF OCTABROMOBIPHENYL AND DECABROMODIPHENYL OXIDE. ENVIRON
                HEALTH PERSPECT. 11:  153-161.

                US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  BROMINATED DIPHENYL ETHER. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

DIAZINON                          000333-41-5
        005892  DAVIES DB AND BJ HOLUB. 1979. COMPARATIVE  SUSCEPTIBILITY OF  MALE AND FEMALE RATS TO DIETARY DIAZINON TOXICITY. J NUTR.
                109(6): XXVIII.

                DAVIES DB AND BJ HOLUB. 1980. COMPARATIVE  SUBACUTE TOXICITY  OF DIETARY DIAZINON IN THE MALE AND FEMALE RAT. TOXICOL APPL
                PHARMACOL. 54(3):  359-367.

                DAVIES DB AND BJ HOLUB. 1980. TOXICOLOGICAL EVALUATION OF DIETARY DIAZINON IN THE RAT. ARCH ENVIRON CONTAM TOXICOL. 9(6):
                637-650.

                US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  DIAZINON. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE, WASHINGTON, DC.

DIBENZOFURAN                    000132-64-9
        005409  US EPA. 1987. HEALTH  EFFECTS ASSESSMENT FOR DIBENZOFURAN.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.
                                                                                                                                          R1-24

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                                   REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


DIBROMOBENZENE,  1,4-          000106-37-6
        005893  CARLSON GP AND RG TARDIFF. 1977. EFFECT OF  1,4-DIBROMOBENZENE  AND 1,2,4-TRIBROMOBENZENE ON XENOBIOTIC METABOLISM.  TOXICOL
                APPL PHARMACOL. 42(1):  189-196.

                US  EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  BROMOBENZENES.  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

DIBROMOCHLOROMETHANE          000124-48-1
        005894  NTP (NATIONAL TOXICOLOGY PROGRAM). 1985.  TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORODIBROMOMETHANE IN F344/N RATS AND
                B6C3F1 MICE (GAVAGE  STUDIES). NTP TR282.  NTIS PB86-166675.

                US  EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  BROMOCHLOROMETHANES. PREPARED BY THE OFFICE OF HEALTH  AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

                US  EPA. 1989.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DIBROMOCHLOROMETHANE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

DIBUTYL  PHTHALATE              000084-74-2
        005622  SMITH, CC. 1953. TOXICITY OF BUTYL STEARATE, DIBUTYL SEBACATE, DIBUTYL PHTHALATE AND METHOXYETHYL OLEATE. ARCH HYG OCCUP MED
                7:  310-318.

                US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC  ACID ESTERS.  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE,
                WASHINGTON, DC.

DICHLOROBENZENE,   1,2-        000095-50-1
        005828  NTP (NATIONAL TOXICOLOGY PROGRAM). 1985.  TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1,2-DICHLOROBENZENE IN F344/N  RATS AND
                B6C3F1 MICE (GAVAGE  STUDIES). US DHHS, NIK TECH REP SER NO 255. ALSO PUBL AS NIH PUBL NO 86-2511 AND PB86-144888.

                US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR DICHLOROBENZENES.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA  AND ASSESSMENT  OFFICE, CINCINNATI,  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,  WASHINGTON,
                DC.

DICHLOROBENZENE,   1,3-        000541-73-1
        005414  US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR DICHLOROBENZENES.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE,
                WASHINGTON, DC.
                                                                                                                                         R1-25

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                                   REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


DICHLOROBENZENE,  1,4-        000106-46-7
        005787  RILEY, RA, IS CHART,  A DOSS, ET AL.  1980. PARA-DICHLOROBENZENE: LONG-TERM INHALATION STUDY IN THE  RAT. ICI REPORT NSO
                CTL/P/447. AUGUST,  1980.

                US EPA. 1987. HEALTH  EFFECTS ASSESSMENT  FOR DICHLOROBENZENES.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,  WASHINGTON,
                DC.

DICHLOROBUTENES
        005415  US EPA. 1987. HEALTH  AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  DICHLOROBUTENES. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

DICHLORODIFLUOROMETHANE           000075-71-8
        005496  CLAYTON, WJ,  JR.  1967. FLUOROCARBON  TOXICITY AND BIOLOGICAL  ACTION. FLUORINE CHEM REV  1(2): 197-252.

                US EPA. 1987. HEALTH  EFFECTS ASSESSMENT  FOR FULLY HALOGENATED  METHANES. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

        005498  SHERMAN, H. 1974.  LONG-TERM FEEDING  STUDIES IN RATS AND DOGS WITH DICHLORODIFLUOROMETHANE (FREON 12 FOOD FREEZANT). HASKELL
                LABORATORY REPORT  NO  24-74, UNPUBLISHED, COURTESY DU PONT  DE NEMOURS CO.

                US EPA. 1987. HEALTH  EFFECTS ASSESSMENT  FOR FULLY HALOGENATED  METHANES. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

DICHLOROETHANE, 1,1-          000075-34-3
        005790  HOFMANN, HT,  H BIRNSTIEL AND P J08ST. 1971. ON THE INHALATION  TOXICITY OF 1,1- AND 1,2-DICHLOROETHANE. ARCH TOXIKOL
                27:248-265.

                US EPA. 1984. HEALTH  EFFECTS ASSESSMENT  FOR 1,1-DICHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

DICHLOROETHYLENE,  1,1-           000075-35-4
        005419  QUAST, JF, CG HUMISTON, CE WADE, ET  AL.  1983. A CHRONIC TOXICITY AND ONCOGENICITY STUDY IN RATS AND SUBCHRONIC TOXICITY STUDY
                IN DOGS ON INGESTED VINYLIDENE CHLORIDE. FUND APPL TOX1COL  3(1):55-62.

                US EPA 1988.  UPDATED  HEALTH EFFECTS  ASSESSMENT FOR 1,1-DICHLOROETHYLENE (VINYLIDINE CHLORIDE). PREPARED BY THE OFFICE OF
                HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF EMERGENCY
                AND  REMEDIAL RESPONSE, WASHINGTON, DC.
                                                                                                                                          R1-26

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                                   REFERENCES  FOR  HEAST TABLE  1: SUBCHRONIC  AND  CHRONIC TOXICITY
                                                         (OTHER  THAN  CARCINOGENICITY)                                      January 1992


DICHLOROETHYLENE,  1,2-C-           000156-59-2
        005420  MCCAULEY PT, M ROBINSON, LW CONDIE,  ET AL. NO DATE.  THE EFFECTS OF SUBACUTE AND SUBCHRONIC ORAL EXPOSURE  TO
               CIS-1.2-DICHLOROETHYLENE IN RATS.  HEALTH EFFECTS RESEARCH  LABORATORY,  US EPA, CINCINNATI, OH.

               US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 1,2-C-DICHLOROETHYLENE.  PREPARED BY THE OFFICE OF HEALTH  AND  ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF EMERGENCY  AND  REMEDIAL RESPONSE,
               WASHINGTON, DC.

DICHLOROETHYLENE,  1,2-T-           000156-60-5
        005895  BARNES DU, UM SANDERS, KL SHITE JR,  ET AL. 1985. TOXICOLOGY OF TRANS-1,2-DICHLOROETHYLENE IN THE MOUSE. DRUG CHEM TOXICOL. 8:
               373- 392.

               US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 1,2-T-DICHLOROETHYLENE.  PREPARED BY THE OFFICE OF HEALTH  AND  ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF EMERGENCY  AND  REMEDIAL RESPONSE,
               WASHINGTON, DC.

DICHLOROPHENOL,  2,3-         000576-24-9
        005315  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

DICHLOROPHENOL,  2,4-         000120-83-2
        005314  EXON, JH, AND LD KOLLER. 1985.  TOXICITY OF 2-CHLOROPHENOL, 2,4- DICHLOROPHENOL AND  2,4,6-TRICHLOROPHENOL. IN: WATER
               CHLORINATION: CHEM, ENVIRON IMPACT AND HEALTH EFF,  JOLLEY  ET AL.,  ED.  VOL. 5.

               US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

               US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR 2-CHLOROPHENOL AND 2,4-  DICHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  EMERGENCY AND
               REMEDIAL RESPONSE, WASHINGTON,  DC.

DICHLOROPHENOL,  2,5-         000583-78-8
        005316  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

DICHLOROPHENOL,  2,6-         000087-65-0
        005317  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.
                                                                                                                                         R1-27

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                                  REFERENCES FOR  HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY
                                                        (OTHER THAN  CARCINOGENICITY)                                     January 1992


DICHLOROPHENOL,  3,4-         000095-77-2
        005318  US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED  BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

DICHLOROPHENOL,  3,5-         000591-35-5
        005319  US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED  BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

DICHLOROPHENOXY  ACETIC  ACID, 2,4-           000094-75-7
        010265  DOW CHEMICAL CO. 1983. ACC NO.  251473.

DICHLOROPHENOXY)BUTYRIC ACID,  4-,  (2,4-           000094-82-6
        005890  RHODIA INC. 1969.  CONFIDENTIAL BUSINESS  INFORMATION, UNPUBLISHED STUDY. MRID NO. 0092165.

               US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2,4- DB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON,  DC

DICHLOROPROPANE,  1,1-        000078-99-9
        005890  US EPA.  1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES. PREPARED BY  THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

DICHLOROPROPANE,  1,2-        000078-87-5
        005898  NITSCHKE,KD,,A JOHNSON, DL WACKERLE,  JE PHILLIPS AND DA DITTENBER. 1988. PROPYLENE DICHLOR1DE: A 13 WEEK  INHALATION
               TOXICITY STUDY WITH RATS, MICE  AND RABBITS. DOW CHEMICAL CO. MAMMALIAN AND  ENVIRONMENTAL TOXICOLGY RESEARCH LABORATORY,
               MIDLAND,MI.

               US EPA.  1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES. PREPARED BY  THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

DICHLOROPROPANE,  1,3-        000142-28-9
        005899  US EPA.  1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES. PREPARED BY  THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

DICHLOROPROPANE,  2,2-          000594-20-7
        005900  US EPA.  1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES. PREPARED BY  THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.



                                                                                                                                      R1-28

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                                   REFERENCES  FOR HEAST  TABLE  1: SUBCHRONIC  AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


DICHLOROPROPENE,  1,3-          000542-75-6
        005901   DOW CHEMICAL CO. 1973. MRID NOS. 00067977, 0039684. US EPA,  WASHINGTON,  DC.

                US EPA. 1989. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENTFOR 1,3-DICHLOROPROPENE. PREPARED BY  THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

        010351   LOMAX, LG, WT STOTT, KA JOHNSON, ET  AL. 1989. THE CHRONIC  TOXICITY AND ONCOGENICITY OF INHALED TECHNICAL-GRADE
                1,3-DICHLOROPROPENE IN RATS AND MICE. FUND APPL TOXICOL. 12:418-431.

                US EPA. 1989. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR  1,3-DICHLOROPROPENE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

DICHLORPROP                     000120-36-5
        005896   US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  DICHLOROPROP.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

DICYCLOPENTADIENE             000077-73-6
        005425   LITTON BIONETICS,  INC. 1980. MAMMALIAN  TOXICOLOGICAL EVALUATION OF DIMP AND DCPD, (PHASE 2). LITTON BIONETICS, INC.,
                KENSINGTON, MD CONTRACT DAMB. 17-77-C-7003. NT IS AD-A082685.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR  CYCLOPENTADIENE AND DICYCLOPENTADIENE. PREPARED BY THE OFFICE OF
                HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID
                WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

DIELDRIN                         000060-57-1
        005429   WALKER, AIT, DE STEVENSON, J ROBINSON,  ET AL. 1969. THE TOXICOLOGY AND PHARMACODYNAMICS OF DIELDRIN (HEOD): TWO-YEAR ORAL
                EXPOSURE OF RATS AND DOGS. TOXICOL APPL PHARMACOL  15:345-373.

DIETHYL  PHTHALATE             000084-66-2
        005620   BROWN, D, KR BUTTERWORTH, IF GAUNT ET AL. 1978. SHORT-TERM ORAL TOXICITY STUDY OF DIETHYL PHTHALATE IN THE RAT. FOOD COSMET
                TOXICOL  16: 415-422.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS. PREPARED BY THE  OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND
                REMEDIAL RESPONSE, WASHINGTON, DC.

DIETHYL-P-NITROPHENYL PHOSPHATE          000311-45-5
        005922   US EPA. 1989.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DIETHYL-P-NITROPHENYL PHOSPHATE.  PREPARED BY THE OFFICE OF
                HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID
                WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC..



                                                                                                                                         R1-29

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


DIETHYLANILINE,  N,N-         000091-66-7
        005903  US EPA. 1987.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  N,N-  DIETHYLANILINE.  PREPARED BY THE  OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

DIETHYLENE  GLYCOL  MONOBUTYL  ETHER           000112-34-5
        005482  US EPA. 1984.  HEALTH EFFECTS ASSESSMENT FOR GLYCOL  ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE,
               WASHINGTON,  DC. EPA 540/1-86-052.

DIETHYLENE  GLYCOL  MONOETHYL  ETHER            000111-90-0
        005476  HALL, DE, FS LEE, P AUSTIN AND  FA  FAIRWEATHER. 1966. SHORT-TERM FEEDING STUDY WITH  DIETHYLENE GLYCOL MONOETHYL ETHER IN RATS.
               FOOD COSMET  TOXICOL  4: 263.

               US EPA. 1984.  HEALTH EFFECTS ASSESSMENT FOR GLYCOL  ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFF ICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
               WASHINGTON,  DC. EPA 540/1-86-052.

        005478  SMYTH, HF, CP  CARPENTER AND CB  SHAFFER. 1964.  A 2-YEAR STUDY OF DIETHYLENE GLYCOL MONOETHYL ETHER IN RATS. FOOD COSMET
               TOXICOL 2: 641-642.

               US EPA. 1984.  HEALTH EFFECTS ASSESSMENT FOR GLYCOL  ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE,
               WASHINGTON,  DC. EPA 540/1-86-052.

DIETHYLFORMAMIDE              000617-84-5
        010437  ARGUS MF, JC ARCOS AND C HOCH-LIGETI. 1965. THE CARCINOGENIC ACTIVITY OF PROTEIN-DENATURING AGENTS: HEPATOCARCINOGENICITY OF
               DIOXANE. J.  NATL CANCER INST. 35:  949-958.

               US EPA. 1986.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIETHYLFORMAMIDE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

DIETHYLHYDRAZINE,  1,2-           001615-80-1
        005921  US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1,2-  DIETHYLHYDRAZINE.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

DIMETHOATE                      000060-51-5
        005923  AMERICAN CYANAMID COMPANY. 1986. MRID NO 00164177.  US EPA, WASHINGTON DC.

               US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHOATE. PREPARED BY  THE OFFICE OF  HEALTH AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.


                                                                                                                                        R1-30

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                                   REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                     January 199Z


DIMETHYL  PHTHALATE            000131-11-3
        010267  LEHMAN AJ. 1955.  INSECT REPELLANTS.  ASSOC  FOOD DRUG OFFICE,  US QUART BULL.  19:87.

                US EPA. 1987. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR PHTHALIC ACID. ALKYL, ARYL, AND ALKYL/ARYL ESTERS.  PREPARED BY THE
                OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE  OF
                SOLID WASTE AND EMERGENCY RESPONSE,  WASHINGTON, DC.

DIMETHYLANILINE, N,N-          000121-69-7
        005924  ABDO K, M WOLFE AND R  HILES. 1984. SUBCHRONIC TOXICITY OF N,N- DIMETHYLANILINE TO F-344 RATS AND B6C3F1 MICE.  FED PROC.
                43(3): 1698.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR N.N-DIMETHYLANILINE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

DIMETHYLFORMAMIDE,  N,N-           000068-12-2
        005925  BECCI, PJ, KA VOSS, WD JOHNSON, ET AL.  1983. SUBCHRONIC FEEDING STUDY OF N.N-DIMETHYLFORMAMIDE IN RATS AND MICE. J AM COLL
                TOXICOL 2(6): 371-378.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR N.N-DIMETHYLFORMAMIDE. PREPARED BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

        010352  CIRLA, AM, G PISATI, E INVERNIZZI ET AL. 1984. EPIDEMIOLOGICAL STUDY ON  WORKERS EXPOSED TO LOW DIMETHYLFORMAMIDE
                CONCENTRATIONS. G ITAL MED LAV. 6(3-4):149-156.

                CATENACCI, G, D GRAMPELLA, R TERZI,  ET  AL.  1984. HEPATIC FUNCTION IN SUBJECTS EXPOSED TO ENVIRONMENTAL CONCENTRATIONS OF DMF
                LOWER THAN THE ACTUALLY PROPOSED TLV. G ITAL MED LAV. 6(3-4):157-158.

DIMETHYLPHENOL,  2,3-          000526-75-0
        005926  US EPA. 1986.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR  DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH  AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

DIMETHYLPHENOL,  2,4-          000105-67-9
        010266  US EPA. 1989. NINETY-DAY GAVAGE STUDY IN ALBINO MICE USING 2,4-DIMETHYLPHENOL. STUDY NO. 410-2831, PREPARED  BY DYNAMAC
                CORPORATION, ROCKVILLE, MD, FOR THE OFFICE  OF SOLID WASTE AND  EMERGENCY  RESPONSE, WASHINGTON, DC.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR DIMETHYLPHENOLS.  PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.
                                                                                                                                         R1-31

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                        (OTHER THAN  CARCINOGENICITY)                                      January 1992


DIMETHYLPHENOL,  2,5-         000095-87-4
        005928  US EPA.  1986.   HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

DIMETHYLPHENOL,  2,6-         000576-26-1
        005431  VELDRE,  IA AND  HJ JANES. 1979. TOXICOLOGICAL  STUDIES OF SHALE OILS, SOME OF THEIR COMPONENTS AND  COMMERCIAL PRODUCTS. ENVIRON
               HEALTH PERSPECT  30:141-146.

               US EPA.  1987. HEALTH EFFECTS  ASSESSMENT FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
               DC.

DIMETHYLPHENOL,  3,4-         000095-65-8
        005437  VELDRE,  IA AND  HJ JANES. 1979. TOXICOLOGICAL  STUDIES OF SHALE OILS, SOME OF THEIR COMPONENTS AND  COMMERCIAL PRODUCTS. ENVIRON
               HEALTH PERSPECT  30:141-146.

               US EPA.  1987. HEALTH EFFECTS  ASSESSMENT FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
               DC.

DIMETHYLTEREPHTHALATE        000120-61-6
        005930  NCI (NATIONAL CANCER INSTITUTE).  1979. BIOASSAY  OF DIMETHYL  TEREPHTHALATE FOR POSSIBLE CARCINOGENICITY. DHEW/PUB/NIH 79-1376,
               NCI-CG-TR121.

               US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYL AND METHYL  TEREPHTHALATE. PREPARED BY THE OFFICE OF
               HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA  AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID
               WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

DIMETHYLUREA,  N,N-            000598-94-7
        005931  US EPA.  1984.   HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  N,N- DIMETHYLUREA.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

DI-N-OCTYL  PHTHALATE         000117-84-0
        010275  PIEKACZ H. 1971. EFFECT OF DIOCTYL AND DIBUTYL PHTHALATES ON THE ORGANISM OF RATS AFTER ORAL ADMINISTRATION IN PROLONGED
               EXPERIMENT. II. SUBACUTE AND  CHRONIC TOXICITY. ROCZ PANSTW ZAKL  HIG. 22(3): 295-307.

               US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACID, ALKYL, ARYL, AND ALKYL/ARYL ESTERS. PREPARED BY
               THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE
               OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,  WASHINGTON, DC.
                                                                                                                                         R1-32

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                                   REFERENCES FOR HEAST TABLE  1:  SUBCHRONIC  AND CHRONIC TOXICITY
                                                        (OTHER THAN  CARCINOGENICITY)                                     January 1992


DINITRO-0-CRESOL,  4,6-      000534-52-1
        008883  US EPA. 1986.   HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  OINITROCRESOLS. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

DINITRO-P-CRESOL,  2,6-      000609-93-8
        005934  US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  2,6- DINITRO-P-CRESOL. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

DINITROBENZENE,  1,2-         000528-29-0
        010201  CODY TE, S WITHERUP, L HASTINGS, K STEMMER  AND RT CHRISTIAN.  1981. 1,3-DINITROBENZENE: TOXIC EFFECT IN VIVO AND IN VITRO. J
               TOXICOL ENVIRON HEALTH. 7(5):829-847.

               US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  DINITROBENZENES (0-, M-, P-). PREPARED BY THE OFFICE OF HEALTH
               AND ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
               AND EMERGENCY  RESPONSE, WASHINGTON, DC.

DINITROBENZENE,  1,3-         000099-65-0
        008884  CODY TE, S WITHERUP, L HASTINGS, K STEMMER  AND RT CHRISTIAN.  1981. 1,3-DINITROBENZENE: TOXIC EFFECT IN VIVO AND IN VITRO. J
               TOXICOL ENVIRON HEALTH. 7(5):829-847.

DINITROBENZENE,  1,4-         000100-25-4
        010202  CODY TE, S WITHERUP, L HASTINGS, K STEMMER  AND RT CHRISTIAN.  1981. 1,3-DINITROBENZENE: TOXIC EFFECT IN VIVO AND IN VITRO. J
               TOXICOL ENVIRON HEALTH. 7(5):829-847.

               US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  DINITROBENZENES (0-, M-, P-). PREPARED BY THE OFFICE OF HEALTH
               AND ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
               AND EMERGENCY  RESPONSE, WASHINGTON, DC.

DINITROPHENOL,  2,3-          000066-56-8
        005936  US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  DINITROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

DINITROPHENOL,  2,4            000051-28-5
        010438  HORNER WD.  1942.  DINITROPHENOL AND ITS RELATION TO FORMATION OF CATARACTS. ARCH OPHTHALMOL. 27: 1097-1121.

               US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  DINITROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON DC.
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                                  REFERENCES  FOR  HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                        (OTHER  THAN  CARCINOGENICITY)                                     January 1992


DINITROPHENOL,  2,5-           000329-71-5
        005937  US EPA.  1984.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE  FOR DJNITROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

DINITROPHENOL,  2,6-           000573-56-8
        005938  US EPA.  1984.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE  FOR DIN1TROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

DINITROPHENOL,  3,5-           000586-11-8
        005939  US EPA.  1984.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE  FOR DINITROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

DINITROTOLUENE,  2,3-         000602-01-7
        005940  US EPA.  1986.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE  FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

DINITROTOLUENE,  2,4-         000121-14-2
        005941  US EPA.  1986.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE  FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

DINITROTOLUENE,  2,5-         000619-15-8
        005942  US EPA.  1986.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE  FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

DINITROTOLUENE,  2,6-         000606-20-2
        005943  US EPA.  1986.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE  FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

DINITROTOLUENE,  3,4-         000610-39-9
        005944  US EPA.  1986.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE  FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF -HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.
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                                   REFERENCES  FOR HEAST  TABLE  1: SUBCHRONIC AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


DINOSEB                           000088-85-7
        005945   DOW CHEMICAL COMPANY.  1981. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED  STUDY. MRID NO 00152675.

                US EPA. 1984. HEALTH  AND ENVIRONMENTAL  EFFECTS PROFILE FOR DINOSEB. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

DIPHENYLAMINE,N,N-            000122-39-4
        005946   THOMAS JO, WE RIBELIN, JR WOODWARD AND  F DEEDS. 1967.  THE CHRONIC TOXICITY  OF DIPHENYLAMINE FOR DOGS. TOXICOL APPL PHARMACOL.
                11: 184-194.

                US EPA. 1985. HEALTH  AND ENVIRONMENTAL  EFFECTS PROFILE FOR N.N-DIPHENYLAMINE. PREPARED BY THE  OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

DIRECT LIGHTFAST BLUE        004399-55-7
        005947   US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  DIRECT LIGHTFAST BLUE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

DISULFOTON                   000298-04-4
        010412   MOBAY CHEMICAL COMPANY.  1985.  MRID NO.  00129456, 00146873, 41115401. AVAILABLE FROM EPA. WRITE TO FOI, EPA, WASHINGTON, DC
                20460.

                US EPA.  1990.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR OISULFOTON. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON DC.

ENDOSULFAN                       000115-29-7
        010439   AMERICAN HOESCHT.  1984. MRID NO. 00147196, 00148264. AVAILABLE FROM EPA.  WRITE TO FOI, EPA, WASHINGTON, DC 20460.

                US EPA. 1987. HEALTH  EFFECTS ASSESSMENT FOR ALPHA- AND 8ETA-ENDO-SULFAN.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

ENDOTHALL                        000145-73-3
        005948   PENNWALT AGCHEM. ND MRID NO 00101735. AVAILABLE FROM US EPA. WRITE TO FOI.  EPA, WASHINGTON, DC 20460.

                US EPA. 1989. HEALTH  AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR  ENDOTHALL. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA ANDASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.
                                                                                                                                         R1-35

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                                   REFERENCES FOR HEAST TABLE  1: SUBCHRONIC AND CHRONIC TOXICITY
                                                          (OTHER  THAN  CARCINOGENICITY)                                       January 1992


ENDRIN                            000072-20-8
        005445  VELSICOL CHEMICAL CORPORATION.  1969. MRID NO. 00030198. AVAILABLE FROM EPA.  WRITE FOI, EPA, WASHINGTON  DC,  20460.

                US  EPA. 1991. DRINKING WATER  CRITERIA DOCUMENT FOR  ENDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE  OF  DRINKING WATER, WASHINGTON,  DC.

                US  EPA. 1987. HEALTH EFFECTS  ASSESSMENT FOR ENDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL  ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE  OF  EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.

EPICHLOROHYDRIN                000106-89-8
        010440  LASKIN S, AR SELLAKUMAR,  M KUSCHNER, ET AL. 1980.  INHALATION CARCINOGENICITY OF EPICHLOROHYDRIN IN NON-INBRED SPRAGUE-DAWLEY
                RATS. J NATL CANCER INST. 65(4): 751-757.

                US  EPA. 1984. HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RESEARCH TRIANGLE PARK, NC. EPA 600/8-83-032F. NTIS PB85-132363.

        005950  QUAST JF, JW HENCK, BJ POSTMA,  ET AL. 1979. EPICHLOROHYDRIN  SUBCHRONIC STUDIES. I. A 90-DAY INHALATION  STUDY IN LABORATORY
                RODENTS. 80 SUBMISSION. MICROFICHE #206200.

                US  EPA. 1984.  HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYDRIN. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RESEARCH TRIANGLE PARK, NC. EPA 600/8-83-032F. NTIS PB85-132363.

        905950  QUAST, JF, BJ HENCK, POSTMA,  DJ SCHUETZ AND MJ MCKENNA. 1979. EPICHLOROHYDRIN - SUBCHRONIC STUDIES. I.  A 90-DAY INHALATION
                STUDY IN LABORATORY RODENTS (FISCHER 344 RATS, SPRAGUE-DAWLEY RATS AND B6C3F1 MICE). DOW CHEMICAL USA,  MIDLAND, MI.

EPTC                               000759-94-4
        005959  PPG INDUSTRIES, INC. 1986. CONFIDENTIAL BUSINESS INFORMATION: UNPUBLISHED STUDY. ACCESSION NO. 263695,  262696. MRID NO.
                00161597.

                US  EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR EPTC. PREPARED BY THEOFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND  EMERGENCY
                RESPONSE, WASHINGTON,  DC.

ETHOPROP                         013194-48-4
        005951  US  EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  ETHOPROP. PREPARED  BY THE OFFICE OF HEALTH  AUD  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND  EMERGENCY
                RESPONSE, WASHINGTON,  DC.
                                                                                                                                           R1-36

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


ETHOXYETHANOL,  2-             000110-80-5
        005468  STENGER, EG,  A  LISLOTT, D MUELLER  ET AL. 1971.  TOXICOLOGY OF ETHYLENE GLYCOL MONOETHYLETHER. ARZNEIM-FORSCH  21(6): 880-885.

               US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE,
               WASHINGTON, DC. EPA 540/1-86-052.

        010441  BARBEE, SJ, JB  TERRILL, DJ OESOUSA AND CC CONAWAY. 1984. SUBCHRONIC INHALATION  TOXICOLOGY OF ETHYLENE GLYCOL MONOETHYL ETHER
               IN THE RAT AND  RABBIT. ENVIRON HEALTH PERSPECT   57: 157- 163.

               US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE,
               WASHINGTON, DC. EPA 540/1-86-052.

        005470  MELNICK, RL.  1984. TOXICITIES OF ETHYLENE GLYCOL AND ETHYLENE  GLYCOL MONOETHYL  ETHER IN FISCHER  344/N RATS AND B6C3F1 MICE.
               ENVIRON HEALTH  PERSPECT  57: 147-155.

               US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR 2-ETHOXY-ETHANOL. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

ETHOXYETHANOL ACETATE,  2-  000111-15-9
        REFER TO REFERENCES FOR HEAST TABLE 2.

ETHOXYETHANOL DODECANOATE,  2-                 000106-13-8
        005956  US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2- ETHOXYETHANOL ESTERS. PREPARED  BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

ETHOXYETHANOL PHOSPHATED,  2-                  068554-00-7   .
        005955  US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2- ETHOXYETHANOL ESTERS. PREPARED  BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

ETHOXYETHYL ACRYLATE,  2-    000106-74-1
        005953  US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2- ETHOXYETHANOL ESTERS. PREPARED  BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

ETHOXYETHYL METHACRYLATE,  2-       002370-63-0
        005954  US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2- ETHOXYETHANOL ESTERS. PREPARED  BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.
                                                                                                                                        R1-37

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                                   REFERENCES FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                        (OTHER THAN  CARCINOGENICITY)                                     January 1992


ETHYL-0-XYLENE,  4-                    000934-80-5
        008882  US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  METHYL ETHYL BENZENES. PREPARED  BY THE OFFICE OF  HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY  RESPONSE, WASHINGTON, DC.

ETHYL  ACETATE                  000141-78-6
        005957  US EPA.  1986. RAT ORAL SUBCHRONIC  STUDY WITH  ETHYL ACETATE.  OFFICE OF SOLID  WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

               US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYL ACETATE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
               AND EMERGENCY RESPONSE, WASHINGTON, DC.

ETHYL  CHLORIDE                 000075-00-3
        010371  SCORTICHINI  BH, KA JOHNSON,  JJ MOMANY-PFRUENDER  ET AL. 1986.  ETHYL CHLORIDE:  INHALATION TERATOLOGY STUDY IN CF-1 MICE. DOW
               CHEMICAL CO. EPA 86-870002248.

ETHYL  ETHER                     000060-29-7
        010396  AMERICAN BIOGENICS CORP.  1986.  90-DAY GAVAGE STUDY IN RATS USING ETHYL ETHER. STATUS REPORT  FOR ABC STUDY NO. 410-2343
               3/18/86.

               US EPA.   1987.  HEALTH EFFECTS ASSESSMENT FOR ETHYL ETHER. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE  OF SOLID WASTE AND EMERGENCY RESPONSE,
               WASHINGTON,  DC.

ETHYL  METHACRYLATE            000097-63-2
        005961  BORZELLECA JF, PS LARSON, GR HENNIGAR, ET AL. 1964. STUDIES  ON THE CHRONIC ORAL TOXICITY OF  MONOMERIC ETHYL ACRYLATE AND
               METHYL METHACRYLATE. TOXICOL APPL  PHARMACOL.  6:  29-36.

               US EPA.  1986.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  ETHYL METHACRYLATE. PREPARED BY  THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY  RESPONSE, WASHINGTON, DC.

ETHYLANILINE, N-              000103-69-5
        005958  US EPA.  1986.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  N- ETHYLANILINE.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY  RESPONSE, WASHINGTON, DC.
                                                                                                                                        R1-38

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC  AND  CHRONIC TOXICITY
                                                          (OTHER THAN  CARCINOGENICITY)                                       January 1992


ETHYLBENZENE                    000100-41-4
        005447  WOLF, MA, VK ROUE, DO  MCCOLLISTER, RL HOLLINGSUORTH AND F OYEN.  1956. TOXICOLOGICAL STUDIES OF CERTAIN ALKYLATED BENZENE AND
                BENZENES. AMA ARCH IND HEALTH  14:387-398.  CITED IN US EPA,  1985.

                US  EPA.  1984. HEALTH EFFECTS ASSESSMENT FOR ETHYLBENZENE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.

                US  EPA  1986. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR ETHYLBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

        005446  ANDREW,  FD, RL BUSHCOHBOM, WC CANNON, ET AL. 1981. TERATOLOGIC ASSESSMENT OF ETHYLBENZENE AND 2-ETHOXYETHANOL. BATTELLE
                PACIFIC  NORTHWEST LABORATORY, RICHLAND, WA. NTIS PB83-208074.  P 108.

                HARDIN BD, GP BOND, MR SIKOV, ET AL. 1981.  TESTING OF SELECTED WORKPLACE CHEMICALS  FOR TERATOGENIC POTENTIAL. SCAND J WORK
                ENVIRON  HEALTH 7:66-75.

ETHYLENE  CYANOHYDRIN          000109-78-4
        005780  SAUERHOFF, MW, WH BRAUN, JC RAMSEY ET AL. 1976.  TOXICOLOGICAL  EVALUATION AND PHARMACOKINETIC PROFILE OF B-
                HYDROXYPROPIONITRILE IN RATS. J. TOXICOL. ENVIRON. HEALTH. 2(1): 31-44.

                US  EPA.  1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS. PREPARED  BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
                AND  EMERGENCY RESPONSE, WASHINGTON, DC.

ETHYLENE  DIAMINE               000107-15-3
        005796  YANG, RS, RH CARMAN, RR MARONPOT, ET AL. 1983. ACUTE AND SUBCHRONIC TOXICITY OF ETHYLENEDIAMINE IN LABORATORY ANIMALS. FUND
                APPL TOXICOL  3(6):512-520

                US  EPA.  1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ETHYLENEDIAMINE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.
                                                                                                                                          R1-39

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                                  REFERENCES  FOR HEAST  TABLE  1: SUBCHRONIC  AND CHRONIC TOXICITY
                                                        (OTHER THAN  CARCINOGENICITY)                                     January 1992


ETHYLENE  GLYCOL                000107-21-1
        005452  MARONPOT,  RR, JP ZELENAK, EV WEAVER AND NJ  SMITH. 1983.  TERATOGENICITY  STUDY OF ETHYLENE GLYCOL IN RATS.  DRUG CHEM TOXICOL
               6(6):  579-594.

               US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR ETHYLENE GLYCOL. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE, WASHINGTON,
               DC.

        005454  DEPASS,  LR, RH GARMAN, MD WOODSIDE ET AL.  1986. CHRONIC  TOXICITY AND ONCOGENICITY STUDIES OF ETHYLENE  GLYCOL IN RATS  AND
               MICE.  FUND APPL TOXICOL 7:547-565.

               US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR ETHYLENE GLYCOL. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE, WASHINGTON,
               DC.

ETHYLENE  GLYCOL  MONOBUTYL  ETHER           000111-76-2
        010353  DODD DE, WM SWELLINGS, RR MAROMPOT, ET AL.  1983. ETHYLENE  GLYCOL MONOBUTYL ETHER: ACUTE, 9-DAY AND 90-DAY VAPOR INHALATION
               STUDIES  IN FISCHER 344 RATS. TOXICOL APPL  PHARMACOL 68:405-414.

ETHYLENE  THIOUREA             000096-45-7
        010397  GRAHAM SL, KJ DAVIS, WH HANSEN AND CH GRAHAM.  1975.  EFFECTS OF PROLONGED ETHYLENE THIOUREA INGESTION ON THE THYROID OF
               THE RAT. FOOD COSMET TOXICOL.  13: 493-499.

ETHYLTOLUENE,  M-              000620-14-4
        005963  US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR  METHYL ETHYL BENZENE. PREPARED BY THE OFFICE  OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE  OF  SOLID WASTE  AND
               EMERGENCY  RESPONSE, WASHINGTON, DC.

ETHYLTOLUENE,  0-              000611-14-3
        005962  US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR  METHYL ETHYL BENZENE. PREPARED BY THE OFFICE  OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE  OF  SOLID WASTE  AND
               EMERGENCY  RESPONSE. WASHINGTON, DC.

ETHYLTOLUENE,  P-              000622-96-8
        005964  US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR  METHYL ETHYL BENZENE. PREPARED BY THE OFFICE  OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE  OF  SOLID WASTE  AND
               EMERGENCY  RESPONSE, WASHINGTON, DC.

FLUORANTHENE                    000206-44-0
        010168  US EPA.  1988. 13-WEEK MOUSE ORAL SUBCHRONIC TOXICITY STUDY.  PREPARED BY TOXICITY RESEARCH LABORATORIES, LTD, MUStCEGON, MI FOR
               THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
                                                                                                                                        R1-40

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                                   REFERENCES FOR  HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                         (OTHER  THAN  CARCINOGENICITY)                                      January  1992


FLUORENE                          000086-73-7
        010169 US EPA. 1989.  MOUSE ORAL SUBCHRONIC STUDY. PREPARED BY TOXICITY RESEARCH LABORATORIES, LTD, MUSKEGON, MI, FOR THE OFFICE OF
               SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

FLUORIDE                          016984-48-8
        005965 HODGE HC. 1950. THE CONCENTRATION OF  FLUORIDES IN DRINKING WATER TO  GIVE THE POINT  OF MINIMUM CARIES WITH MAXIMUM SAFETY. J.
               AM. DENT. ASSOC.  40: 436.

               US EPA. 1989.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR FLUORIDE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA ANDASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

FLURIDONE                        059756-60-4
        005966 ELANCO PRODUCTS COMPANY, DIVISION OF  ELI LILLY AND COMPANY.  1980.  CONFIDENTIAL  BUSINESS INFORMATION, UNPUBLISHED STUDY.
               ACCESSION NOS  070933, 070939.  MRID NO. 00103251, 00103305.

               US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FLURIDONE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
               AND EMERGENCY  RESPONSE, WASHINGTON, DC.

FOLPET                            000133-07-3
        005967 CHEVRON CHEMICAL  CORPORATION.  1986. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED  STUDY. ACCESSION NO 263772. MRID NO.
               00161315.

               US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FOLPET. PREPARED BY  THE  OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

FORMALDEHYDE                     000050-00-0
        010398 TIL HP, RA WOUTERSEN, VJ FERON ET AL.  1989.  TWO-YEAR DRINKING WATER STUDY OF  FORMALDEHYDE IN RATS. FOOD CHEM TOXICOL. 27:
               77-87.

               US EPA.  1989.  DRAFT DRINKING WATER  HEALTH ADVISORY  FOR FORMALDEHYDE.  OFFICE  OF DRINKING WATER,  WASHINGTON, DC.

FORMALDEHYDE  CYANOHYDRIN     000107-16-4
        005782 US EPA. 1988.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS. PREPARED  BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
               AND EMERGENCY  RESPONSE, WASHINGTON, DC.

FORMIC ACID                      000064-18-6
        010268 MALORNY G. 1969.  ACUTE AND CHRONIC TOXICITY OF FORMIC ACID AND FORMATE. Z ERNACHRUNGSWISS. 9: 332-339.
                                                                                                                                        R1-41

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                                  REFERENCES  FOR  HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC  TOXICITY
                                                        (OTHER  THAN  CARCINOGENICITY)                                      January 1992


FURAN                             000110-00-9
        005462  SRI (SOUTHERN RESEARCH  INSTITUTE). 1982.  SUBCHRONIC TOXICITY REPORT  ON FURAN (CS6202) IN B6C3F1  MICE. PREPARED  FOR NATIONAL
               TOXICOLOGY PROGRAM UNDER CONTRACT NO.  1-CP-95641-01.  BETHESDA, MD.

               US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR FURAN. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

FURFURAL                         000098-01-1
        005466  SRI (SOUTHERN RESEARCH  INSTITUTE). 1981.  90 DAY RAT REPORT.  UNPUBLISHED STUDY PERFORMED FOR NTP.

GLYCIDALDEHYDE                 000765-34-4
        005968  HINE CH, RJ GUZMAN, MK  DUNLAP, R LIMA  AND GS LOQUVAM.  1961.  STUDIES  ON THE TOXICITY OF GLYCIDALDEHYDE. ARCH ENVIRON HEALTH.
               2: 23-30.

               US EPA.  1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENTFOR GLYCIDALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

HEPTACHLOR                      000076-44-8
        005506  VELSICOL CHEMICAL CORP. 1955. MRID NO  00062599. AVAILABLE UNDER FOI.

HEPTACHLOR EPOXIDE            001024-57-3
        010399  DOW CHEMICAL CO.  1958. MRID NO 00061912.  AVAILABLE  FROM EPA. WRITE TO FOI, EPA,  WASHINGTON, DC 20460.

HEPTANE,  N-                     000142-82-5
        005969  US EPA.  1989.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N HEPTANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

HEXABROMOBENZENE              000087-82-1
        005970  MENDOZA  CE, HM VIJAY, JB SHIELDS AND GW LAVER. 1977.  EFFECTS OF HEXABROMOBENZENE ON THE MALE RAT. TOXICOL APPL  PHARMACOL. 41:
               127- 130.

               US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOBENZENES. PREPARED  BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

HEXACHLOROBENZENE             000118-74-1
        005510  ARNOLD,  DL, CA MOODIE,  SM CHARBONNEAU, ET AL. 1985. LONG-TERM TOXICITY OF HEXACHLOROBENZENE IN THE RAT AND THE  EFFECT OF
               DIETARY  VITAMIN A. FOOD CHEM  TOXICOL  23(9):779-793.
                                                                                                                                       R1-42

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                        (OTHER THAN  CARCINOGENICITY)                                     January 1992


HEXACHLOROBUTADIENE          000087-68-3
        005514  KOCIBA, RJ,  DG KEYS, GC JERSEY,  ET AL. 1977.  RESULTS OF A 2-YEAR CHRONIC TOXICITY STUDY WITH HEXACHLOROBUTADIENE IN RATS.
               AM IND HYG ASSOC  J  38: 589-602.

HEXACHLOROCYCLOHEXANE, DELTA- AND  EPSILON-
        002222  US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROCYCLOHEXANES.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

HEXACHLOROCYCLOHEXANE, GAMMA-          000058-89-9
        005537  ZOECON CORPORATION. 1983.  MRID  NO 00128356. AVAILABLE UNDER  FOI, EPA, WASHINGTON, DC, 20460.

HEXACHLOROCYCLOPENTADIENE   000077-47-4
        0010445 BATTELLE NORTHWEST LABORATORIES. 1984. INHALATION CARCINOGENESIS BIOASSAY STUDY: SUBCHRONIC STUDY REPORT ON
               HEXACHLOROCYCLOPENTADIENE  IN RATS. SUBMITTED  TO THE NATIONAL TOXICOLOGY PROGRAM.

               US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR HEXACHLOROCYCLOPENTADIENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL
               RESPONSE, WASHINGTON, DC.

        005299  ABDO, KM, CA MONTGOMERY, WM KLUWE, ET AL.  1984. TOXICITY OF  HEXACHLOROCYCLOPENTADIENE: SUBCHRONIC (13-WEEK) ADMINISTRATION  BY
               GAVAGE TO F344 RATS AND B6C3F1  MICE. J APPL TOXICOL  4:75-81.

               US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR HEXACHLOROCYCLOPENTADIENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON,  DC.

HEXACHLOROETHANE              000067-72-1
        005518  GORZINSKI, SJ, RJ NOLAN, SB MCCOLLISTER, ET AL. 1985. SUBCHRONIC ORAL TOXICITY, TISSUE DISTRIBUTION AND CLEARANCE OF
               HEXACHLOROETHANE  IN THE RAT. DRUG CHEM TOXICOL  8(3): 155-169.

               US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  HEXACHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

HEXACHLOROPHENE               000070-30-4
        005972  NATIONWIDE CHEMICAL CORPORATION. 1974. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO 00055365.

               US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXACHLOROPHENE.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE. WASHINGTON,  DC.
                                                                                                                                        R1-43

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                                   REFERENCES FOR  HEAST  TABLE  1: SUBCHRONIC  AND CHRONIC  TOXICITY
                                                         (OTHER  THAN  CARCINOGENICITY)                                      January 1992


HEXAMETHYLENE DIAMINE         000124-09-4
        005973  US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR  HEXAMETHYLENEDIAMINE. PREPARED  BY  THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

HEXANE,  N-                       000110-54-3
        005974  KRASAVAGE WJ,  JL  O'DONOGHUE, GD  DIVINCENZO AND TERHAAR.  1980. RELATIVE NEUROTOXICITY OF METHYL-N-BUTYL KETONE, N-HEXANE AND
               THEIR METABOLITES. TOXICOL APPL  PHARMACOL. 52(3): 433-441.

               US EPA. 1989.   HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N- HEXANE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

        010273  SANAGI S, Y SEKI,  K SUGIMOTO AND M HIRATA. 1980. PERIPHERAL  NERVOUS SYSTEM  FUNCTIONS OF WORKERS EXPOSED TO N-HEXANE AT A
               LOW LEVEL. INT ARCH OCCUP ENVIRON HEALTH. 47: 69-79.

HEXANONE,  2-                     000591-78-6
        005976  US EPA. 1989.   HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N- HEXANONE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

HYDROGEN  SULFIDE               007783-06-4
        010269  WATTERAU H, W  OCKERT AND UG KNAPE. 1964-1965. IN: TOXICITY OF HYDROGEN SULFIDE IN ANIMAL FEEDING. SURVEY OF THE LITERATURE.
               (WESTERMANN ET AL, 1975. LANDWIRTSCH  FORSCH. 28: 70-80.

        010354  CUT. 1983. 90 DAY VAPOR INHALATION TOXICITY STUDY OF HYDROGEN SULFIDE IN B6C3F1 MICE. EPA  OTS PUBLIC FILES. FICHE NO
               0000255-0. DOCUMENT NO  FYI-OTS-0883-0255.

HYDROQUINONE                     000123-31-9
        005526  CARLSON, AJ AND NR BREWER. 1953. TOXICITY STUDIES ON  HYDROQUINONE. PROC SOC EXP BIOL MED 84:  684-688.

               US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR  HYDROQUINONE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

IRON                               007439-89-6
        005527  US EPA. 1984.  HEALTH EFFECTS ASSESSMENT FOR IRON (AND COMPOUNDS). PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON, DC.
                                                                                                                                         R1-44

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                                   REFERENCES  FOR  HEAST TABLE  1: SUBCHRONIC  AND  CHRONIC TOXICITY
                                                         (OTHER  THAN CARCINOGENICITY)                                      January 1992


ISOBUTYL  ALCOHOL               000078-83-1
        005977 US EPA. 1986. RAT  ORAL SUBCHRONIC TOXICITY WITH ISOBUTYL ALCOHOL. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON,
               DC.

               US EPA. 1986. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE  FOR ISOBUTANOL.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

ISOPHORONE                       000078-59-1
        005910 NOR-AM AGRICULTURAL PRODUCTS, INC.  1972. MRID NO.00123976. AVAILABLE UNDER FOI, EPA,  WASHINGTON, DC,  20460.

               NTP (NATIONAL TOXICOLOGY PROGRAM).  1986. TOXICOLOGY AND CARCINOGENESIS  STUDIES OF ISOPHORONE (CAS NO  78-59-1) IN F344/N  RATS
               AND B6C3F1 MICE (GAVAGE STUDIES). NTPTECH REPORT SER  NO 291, NIK PUBL NO 86-2547, NTP 83-168.

ISOPROPALIN                      033820-53-0
        005978 ELANCO PRODUCTS COMPANY. 1969.  CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRIO NO. 00002472.

               US  EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ISOPROPALIN.  PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

LACTONITRILE                     000078-97-7
        005783 US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI, OH FOR
               THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE WASHINGTON DC.

LEAD                               007439-92-1
        010447 REFER TO IRIS.

        910447 REFER TO APPENDIX  A:  TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS

LEAD  ALKYLS
        010448 REFER TO IRIS.

        910448 REFER TO APPENDIX  A:  TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS


LINURON                           000330-55-2
        005990 DU PONT DE NEMOURS AND COMPANY,  INC.  1962. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO  00018374.

               US EPA. 1984. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE  FOR LINURON. PREPARED BY THE OFFICE OF HEALTH  AND  ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.



                                                                                                                                         R1-45

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC TOXICITY
                                                          (OTHER THAN  CARCINOGENICITY)                                      January 1992


MALATHION                        000121-75-5
        005991  MOELLER HC AND JA RIDER.  1962. PLASMA AND RED BLOOD CELL- CHOLINESTERASE ACTIVITY AS INDICATIONS OF THE THRESHOLD OF
                INCIPIENT TOXICITY OF  ETHYL-P-NITROPHENOL THIONOBENZENEPHOSPHORATE  (EPN) AND MALATHION IN  HUMAN BEINGS. TOXICOL APPL
                PHARMACOL. 4: 123-130.

                US EPA. 1984. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR MALATHION. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY
                RESPONSE, WASHINGTON,  DC.

MALEIC ANHYDRIDE               000108-31-6
        005992  JESSUP DC, D ALDRIDGE,  JL SCHARDEIN AND M BLAIR. 1982. THREE-  GENERATION REPRODUCTION STUDY IN RATS (MODIFIED  TO A
                2-GENERATION STUDY). MALEIC ANHYDRIDE IR-79-358. INTERNATIONAL RESEARCH AND DEVELOPMENT CORP. FOR MONSANTO  CO., ST. LOUIS,
                MO.  UNPUBLISHED 80 SUBMISSION. MICROFICHE NO OTS 0206655. DOCUMENT  ID 878214777

                PREACHE M. 1983. CHRONIC  DIETARY ADMINISTRATION OF MALEIC ANHYDRIDE. VOL. 1: NARRATIVE. FYI-OTS SUBMISSION  1283-0277.
                PREPARED BY ITT RESEARCH  INSTITUTE FOR CHEMICAL INDUSTRY INSTITUTE  OF TECHNOLOGY, RESEARCH TRIANGLE PARK, NC.

                US EPA. 1986. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR MALEIC ANHYDRIDE. PREPARED BY THE OFFICE OF HEALTH  AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE
                AND  EMERGENCY RESPONSE, WASHINGTON, DC.

MALEIC HYDRAZIDE               000123-33-1
        005993  UNIROYAL CHEMICAL CO.  1981. ACCESSION NO. 250523.

                US EPA. 1989. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR MALEIC  HYDRAZIDE. PREPARED BY  THE-OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE
                AND  EMERGENCY RESPONSE, WASHINGTON, DC.

MALONONITRILE                   000109-77-3
        005994  PANOV  I, M ZLATEVA AND G  ANTOV. 1972. TOXICOLOGICAL CHARACTERISTICS OF DICYANOMETHANE. CHRONIC EFFECTS IN WHITE RATS. KHIG.
                ZDRAVEOPAZVANE. 15(6):  553-562.

                US EPA. 1986.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR MALONONITRILE. PREPARED  BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

MANCOZEB                         008018-01-7
        005995  US EPA. 1984.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR MANCOZEB. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY
                RESPONSE,  WASHINGTON,  DC.
                                                                                                                                           R1-46

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                                    REFERENCES  FOR HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC  TOXICITY
                                                          (OTHER THAN  CARCINOGENICITY)                                      January 1992


MANEB                              012427-38-2
        005996  MANEB DATA TASK  FORCE. 1986. MRID NO 00161552.  (CITED IN US EPA 1987.)

                ROHM AND HAAS  CO.  1977. HRID NO 00129980.  (CITED  IN US EPA 1987.)

                US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR MANEB.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,  WASHINGTON, DC.

MANGANESE                         007439-96-5
        010355  ROELS,  H,  R  LAWERYS, J-P BUCKET, ET AL. 1987. EP1DEMIOLOGICAL  SURVEY AMONG WORKERS EXPOSED TO  MANGANESE: EFFECTS ON LUNG,
                CENTRAL  NERVOUS  SYSTEM, AND SOME BIOLOGICAL  INDICES. AM J IND  MED.  11:307-327.

                US EPA.  1984.  HEALTH EFFECTS ASSESSMENT FOR MANGANESE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC. ECAO-CIN-H057.

                US EPA.  1984.  HEALTH ASSESSMENT DOCUMENT FOR MANGANESE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH.  EPA  600/8/83-013F. NTIS PB84-229954.

        010356  NRC (NATIONAL  RESEARCH COUNCIL). 1989. RECOMMENDED DIETARY ALLOWANCES, 10TH ED. FOOD AND NUTRITION BOARD, NATIONAL RESEARCH
                COUNCIL, NATIONAL  ACADEMY PRESS, WASHINGTON, DC. P 230-255.

                SCHROEOER,  HA, DD  BALASSA. 1H TIPTON. 1966. ESSENTIAL TRACE  METALS IN MAN: MANGANESE, A STUDY  IN HOMEOSTASIS. J CHRON DIS.
                19:545-571.

                WHO (WORLD HEALTH  ORGANIZATION). 1973. TRACE ELEMENTS IN HUMAN NUTRITION: MANGANESE. REPORT OF A WHO EXPERT COMMITTEE.
                TECHNICAL  REPORT SERVICE, 532. WHO, GENEVA, SWITZERLAND. P 34-36.

                US EPA.  1984.  HEALTH EFFECTS ASSESSMENT FOR MANGANESE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC. ECAO-CIN-H057.

                US EPA.  1984.  HEALTH ASSESSMENT DOCUMENT FOR MANGANESE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH.  EPA  600/8/83-013F. NTIS PB84-229954.

MEPHOSFOLAN                      000950-10-7
        005997  US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  MEPHOSFOLAN.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,   WASHINGTON, DC.
                                                                                                                                            R1-47

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                                    REFERENCES FOR  HEAST  TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                          (OTHER THAN  CARCINOGENICITY)                                       January 1992


MERCURY,  INORGANIC            007439-97-6
        010270  FAWER  RF, V DERIBAUPIERRE, MP GUILLEMIN,  ET AL. 1983. MEASUREMENT OF HAND TREMOR INDUCED  BY  INDUSTRIAL EXPOSURE TO METALLIC
                MERCURY. J IND MED. 40: 204-208

                PIIKIVI  L. 1989. CARDIOVASCULAR REFLEXES  AND LONG-TERM EXPOSURE  TO MERCURY VAPOR.  INT  ARCH OCCUP ENVIRON HEALTH.  61:
                391-395.

                PIIKIVI  L AND H HANNINEN. 1989. SUBJECTIVE SYMPTOMS AND PSYCHOLOGICAL PERFORMANCE OF CHLORINE-ALKALI WORKERS.  SCAND J WORK
                ENVIRON  HEALTH. 15: 69-74.

                PIIKIVI  L AND V TOLONEN. 1989. EEC FINDINGS IN CHLOR-ALKALI  WORKERS SUBJECTED TO LONG-TERM EXPOSURE TO MERCURY VAPOR. BR J
                IND  MED. 46: 370-375.

                US EPA.  1984. HEALTH EFFECTS ASSESSMENT FOR MERCURY. PREPARED  BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF EMERGENCY  AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

        005800  ANDRES P. 1984. IGA-IGG DISEASE IN THE  INTESTINE OF BROWN  NORWAY RATS INGESTING MERCURIC  CHLORIDE. CLIN IMMUNOL IMMUNOPATHOL
                20:488-494.

                BERNAUDIN JF, E DRUET, P DRUET, R  MASSE.  1981. INHALATION  OR INGESTION OF ORGANIC OR INORGANIC MERCURIALS PRODUCE AUTOIMMUNE
                DISEASE  IN RATS. CLIN IMMUNOL IMMUNOPATHOL 20:129-135.

                DRUET  P, E DRUET, F POTDEVIN, C SAPIN.  1978. IMMUNE TYPE GLOMERULONEPHRITIS INDUCED BY HG CL2 IN THE BROWN NORWAY RAT. ANN IMMUNOL.
                129C:777-792.

                US EPA.  1987. PEER REVIEW WORKSHOP ON MERCURY ISSUES. OCTOBER  26-27, 1987. SUMMARY  REPORT. ENVIRONMENTAL CRITERIA AND ASSESSMENT
                OFFICE,  CINCINNATI, OH.

MERPHOS                           000150-50-5
        005998  ABOU-DONIA MB, DG GRAHAM PR TIMMONS AND BL REICHERT. 1980. LATE  ACUTE, DELAYED NEUROTOXIC AND CHOLINERGIC EFFECTS OF S,S,S-
                TRIBUTYLPHOSPHOROTRITHIOITE (MERPHOS)  IN  HENS. TOXICOL APPL  PHARMACOL. 53: 439-457.

                US EPA.  1984. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR MERPHOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

MERPHOS  OXIDE                  000078-48-8
        005999  ABOU-DONIA MB, DG GRAHAM, KM ABDO  AND AA  KOMEIL. 1979. DELAYED NEUROTOXIC, LATE ACUTE  AND CHOLINERGIC EFFECTS  OF  S,S,S-
                TRIBUTYLPHOSPHOROTRITHIOATE (DEF): SUBCHRONIC (90 DAYS) ADMINISTRATION IN HENS. TOXICOLOGY.  14: 229-243.

                US EPA.  1984. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR MERPHOS OXIDE. PREPARED  BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.
                                                                                                                                            R1-48

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                                   REFERENCES  FOR  HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                        (OTHER  THAN  CARCINOGENICITY)                                     January 1992


METHACRYLONITRILE             000126-98-7
        005812  POZZANI,  UC, CR KINKEAD AND JM KING. 1968. THE MAMMALIAN TOXICITY OF METHACRYLONITRILE.  AM  IND HYG ASSOC  J  29(3):202-210.

               US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES, PREPARED  BY  THE OFFICE OF  HEALTH AND
               ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND  ASSESSMENT  OFFICE, CINCINNATI, OH FOR  THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

METHANOL                         000067-56-1
        010271  US EPA. 1986. RAT ORAL SUBCHRONIC TOXICITY STUDY WITH METHANOL.  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.

METHOMYL                         016752-77-5
        005802  E.I. DU PONT DE NEMOURS AND COMPANY, INC. 1968. MRID  NO. 00007091, 00009012.

               US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHOMYL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR  THE OFFICE  OF  SOLID WASTE AND EMERGENCY
               RESPONSE,  WASHINGTON, DC.

METHOXYCHLOR                    000072-43-5
        010357  KINCAID ENTERPRISES, INC.  1986. MRID NO 0015992. AVAILABLE FROM  EPA. WRITE TO FOI, EPA,  WASHINGTON, DC 20460.

METHOXYETHANOL,  2-            000109-86-4
        010372  MILLER RR, LL CALHOUN,  BL  YANO. 1982. ETHYLENE GLYCOL MONOMETHYL ETHER. 13-WEEK VAPOR INHALATION STUDY IN MALE RABBITS.
               REPORT PREPARED FOR THE CMA MARCH 25, 1982.

               MILLER RR, JA AYRES, JL YOUNG, ET AL. 1983. ETHYLENE  GLYCOL MONOMETHYL ETHER. I. SUBCHRONIC VAPOR INHALATION STUDY WITH RATS
               AND RABBITS. FUND APPL TOXICOL 3(1):49- 54.

METHOXYETHANOL ACETATE,  2-          000110-49-6
        REFER TO REFERENCES FOR HEAST TABLE 2.

METHYL ACETATE                 000079-20-9
        010002  TOXICITY  RESEARCH LABORATORY. 1986.  RAT ORAL SUBCHRONIC TOXICITY STUDY WITH METHANOL. SPONSORED BY OFFICE OF SOLID WASTE AND
               EMERGENCY  RESPONSE, US EPA, WASHINGTON, DC.

               US EPA. 1986.  HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ACETATE. PREPARED BY  THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND  ASSESSMENT  OFFICE, CINCINNATI, OH FOR  THE OFFICE OF  SOLID WASTE AND
               EMERGENCY  RESPONSE, WASHINGTON, DC.

METHYL ACRYLATE                000096-33-3
        REFER TO REFERENCES FOR HEAST TABLE 2.
                                                                                                                                      R1-49

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                                   REFERENCES  FOR HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                       January 1992


METHYL CHLOROCARBONATE       000079-22-1
        010006  US EPA. 1989.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHYLCHLOROCARBONATE.  PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

METHYL ETHYL KETONE           000078-93-3
        005558  LABELLE, CW AND H BRIEGER. 1955. VAPOUR TOXICITY OF A COMPOSITE  SOLVENT AND ITS PRINCIPAL COMPONENTS. ARCH  IND HEALTH  12:
                623- 627.

                US EPA.  1989. UPDATED  HEALTH EFFECTS ASSESSMENT FOR METHYL  ETHYL KETONE. PREPARED  BY THE OFFICE OF HEALTH  AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF  EMERGENCY AND
                REMEDIAL RESPONSE,  WASHINGTON, DC

METHYL ISOBUTYL KETONE       000108-10-1
        005563  MICROBIOLOGICAL ASSOCIATES. 1986. SUBCHRONIC  TOXICITY OF METHYL  ISOBUTYL KETONE IN  SPRAGUE-DAWLEY RATS. PRELIMINARY REPORT
                FOR  RESEARCH TRIANGLE  INSTITUTE, RTP, NC STUDY NO 5221.04 JANUARY.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR METHYL  ISOBUTYL  KETONE. PREPARED BY THE  OFFICE OF HEALTH AND  ENVIRONMENTAL
                RESPONSE, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

METHYL ISOCYANATE              000624-83-9
        010013  US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  METHYL  ISOCYANATE. PREPARED BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

METHYL MERCURY                  022967-92-6
        005547  CLARKSON, TW, L AMIN-ZAKI, SK AL-TIKRITI. 1976. AN  OUTBREAK  OF METHYL MERCURY POISONING DUE TO CONSUMPTION  OF CONTAMINATED
                GRAIN. FEDERATION PROCEEDINGS. 35(12):2395-2399.

                NORDBERG, GF, P STRANGERT. 1976. ESTIMATIONS  OF A DOSE-RESPONSE  CURVE FOR LONG-TERM  EXPOSURE TO METHYLMERCURIC COMPOUNDS IN
                HUMAN BEINGS TAKING INTO ACCOUNT VARIABILITY  OF CRITICAL ORGAN CONCENTRATIONS AND BIOLOGICAL HALF- TIME:  A  PRELIMINARY
                COMMUNICATION. IN:  EFFECTS AND DOSE-RESPONSE  RELATIONSHIPS OF TOXIC METALS. GF NORDBERG, ED. ELSEVIER, AMSTERDAM. P. 273-282.

                WHO  (WORLD HEALTH ORGANIZATION). 1976. ENVIRONMENTAL HEALTH  CRITERIA FOR MERCURY. IN: ENVIRONMENTAL HEALTH  CRITERIA 1. WHO,
                GENEVA.

                US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR MERCURY. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.

                US EPA. 1980. AMBIENT WATER QUALITY CRITERIA  DOCUMENT FOR MERCURY.  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS,
                WASHINGTON, DC.



                                                                                                                                          R1-50

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                                  REFERENCES FOR HEAST TABLE  1: SUBCHRONIC AND CHRONIC  TOXICITY
                                                       (OTHER THAN  CARCINOGENICITY)                                     January 1992


METHYL METHACRYLATE           000080-62-6
        010014  BORZELLECA JF, PS LARSON, GR HENNIGAR, ET AL.  1964. STUDIES  ON THE CHRONIC ORAL  TOXICITY OF MONOMER 1C ETHYL ACRYLATE AND
               METHYL  METHACRYLATE.  TOXICOL APPL  PHARMACOL. 6:  29-36.

               US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  METHYL METHACRYLATE.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

METHYL PARATHION               000298-00-0
        010015  MONSANTO CO. 1984. ACCESSION NO  252501-252503, 253346, 253372- 253374. MRID NO.  000139023, 00143965,  00145507. US EPA,
               WASHINGTON, DC.

               US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL PARATHION. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

METHYL STYRENE, ALPHA-        000098-83-9
        REFER TO REFERENCES FOR HEAST TABLE 2.

METHYL STYRENE  (MIXED  ISOMERS)          025013-15-4
        REFER TO REFERENCES FOR HEAST TABLE 2.

METHYL-4-CHLOROPHENOXYACETIC  ACID,  2-           000094-74-6
         (MCPA)
        010007  INDUSTRY TASK FORCE ON MCPA RESEARCH DATA.  1986. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO 00164352,
               00152152.

               US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MCPA AND MCPB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

METHYL-4-CHLOROPHENOXY)BUTYRIC  ACID,  4-(2-           000094-81-5
           (MCPB)
        010008  RHODIA, INC. 1970. CONFIDENTIAL  BUSINESS INFORMATION, UNPUBLISHED  STUDY. MRID NO 00116345.

               RHODIA, INC. 1970. CONFIDENTIAL  BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO  00116344.

               US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MCPA AND MCPB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.
                                                                                                                                     R1-51

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                                  REFERENCES  FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                        (OTHER  THAN  CARCINOGENICITY)                                     January 1992


METHYL-4-CHLOROPHENOXY)PROPIONIC  ACID,2-(2-           000093-65-2
           (MCPP)
        010009  BASF AKTIEGERELLSCHAFT.  1985. CONFIDENTIAL BUSINESS INFORMATION,  UNPUBLISHED STUDY. MRID NO 00158359.

               US EPA.  1984. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR MCPP.  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE. CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE,  WASHINGTON,  DC.

METHYLCYCLOHEXANE             000108-87-2
        010431  KINKEAD  ER, CC HAUN MG SCHNEIDER, ET AL.  1985. CHRONIC INHALATION EXPOSURE OF EXPERIMENTAL ANIMALS TO METHYLCYCLOHEXANE.  GOVT
               REPORTS  ANNOUNCEMENTS AND INDEX, ISSUE  21. 29 P.

               US EPA.   1991.  HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR METHYLCYCLOHEXANE.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY  RESPONSE, WASHINGTON, DC.

METHYLENE-BIS(2-CHLOROANILINE),  4,4'-           000101-14-4
        010413  STULA EF,  JR BARNES, H SHERMAN, CF RE1NHARDY AND JA ZAPP, JU.  1977.  URINARY BLADDER TUMORS IN DOGS FROM
               4,4'-METHYLENE-BIS(2-  CHLOROANILINE) (MOCA). J ENVIRON PATHOL TOXICOL. 1(1): 31-50.

               US EPA.   1990.  HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR 4,4'- METHYLENE-BIS(2-CHLOROANILINE). PREPARED BY THE OFFICE
               OF HEALTH  AND ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF
               SOLID WASTE AND EMERGENCY RESPONSE,  WASHINGTON DC.

METHYLENE BROMIDE             000074-95-3
        REFER TO REFERENCES FOR HEAST TABLE 2.

METHYLENE CHLORIDE            000075-09-2
        005552  NITSCHKE,  KD, JD BURED,  TJ BELL, ET  AL.  1988. METHYLENE CHLORIDE: A 2-YEAR INHALATION TOXICITY AND ONCOGENICITY STUDY IN
               RATS. FUND APPL TOXICOL   (IN PRESS).

        005553  NATIONAL COFFEE ASSOCIATION. 1982. 24-MONTH CHRONIC TOXICITY AND  ONCOGENICITY STUDY OF METHYLENE CHLORIDE IN RATS  FINAL
               REPORT.  PREPARED BY HAZLETON LABORATORIES AMERICA,  INC., VIENNA,  VA. UNPUBLISHED

               US EPA.  1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR METHYLENE CHLORIDE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON, DC.

METHYLENEDIPHENYL  ISOCYANATE,  4,4'-           000101-68-8
        010449  REUZEL PGJ, JHG ARTS,  MHM KUYPERS, ET AL. 1990. CHRONIC TOXICITY/CARCINOGENICITY  INHALATION STUDY OF POLYMERIC
               METHYLENEDIPHENYL DIISOCYANATE AEROSOL  IN RATS. FINAL REPORT.  PREPARED BY CIVO INSTITUTE FOR THE INTERNATIONAL ISOCYANATE
               INSTITUTE.
                                                                                                                                       R1-52

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                                   REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCIN06ENICITY)                                      January  1992


MIREX                             002385-85-5
        005569  SHANNON, VC. 1976.  THE  EFFECTS OF MIREX ON  THE REPRODUCTIVE  PERFORMANCE AND BEHAVIORAL DEVELOPMENT  IN THE PRAIRIE VOLE
                (MICROTUS OCHROGASTER).  PHD DISSERTATION,  IOWA STATE UNIVERSITY, AMES, IA. DISS  ABSTR. B. (3716): 2712-2713.

MOLINATE                         002212-67-1
        010017  STAUFFER CHEMICAL COMPANY. 1981. MRID NO 00079209. US EPA, WASHINGTON, DC.

                US  EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MOLINATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

MOLYBDENUM                       007439-98-7
        910414  KOLVAL'SKIY, W,  GA YAROVAYA AND DM SHMAVONYAN.  1961. CHANGES  OF PURINE METABOLISM IN MAN AND  ANIMALS UNDER CONDITIONS OF
                MOLYBDENUM BIOGEOCHEMICAL PROVINCES. ZH. OBSHCH. BIOL. 22: 179-191. (IN RUSSIAN, TRANSLATION)

NAPHTHALENE                      000091-20-3
        010446  NTP (NATIONAL TOXICOLOGY PROGRAM). 1980. UNPUBLISHED SUBCHRONIC TOXICITY STUDY:  NAPHTHALENE (C52904), FISHER 344 RATS.
                PREPARED BY BATTELLE'S  COLUMBUS LABORATORIES UNDER SUBCONTRACT NO 76-34-106002.

                US  EPA. 1988. HEALTH EFFECTS ASSESSMENT FOR NAPHTHALENE.  PREPARED BY THE OFFICE  OF HEALTH AND  ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,  WASHINGTON,
                DC.

                US  EPA. 1990. DRINKING  WATER HEALTH ADVISORY FOR NAPHTHALENE.  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT,
                OFFICE OF DRINKING  WATER, WASHINGTON, DC, DRAFT.

                US  EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NAPTHALENE. PREPARED  BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

NAPHTHOQUINONE,   1,4-        000130-15-4
        010020  US  EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  1,4- NAPHTHOQUINONE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.
                                                                                                                                         R1-53

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


NICKEL (METALLIC)             007440-02-0
        005579  AMBROSE, AM,  OS  LARSON, JR BORZELLECA AND GR HENNIGAR, JR. 1976.  LONG-TERM TOXICOLOGIC ASSESSMENT OF NICKEL IN RATS AND DOGS.
               J GOOD SCI  TECHNOL   13: 181-187.

               US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR NICKEL. PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR  THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,  WASHINGTON,
               DC.

NICOTINONITRILE                000100-54-9
        005584  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON,  DC.

NITRIC OXIDE                    010102-43-9
        905584  REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

NITRITE                          014797-65-0
        010021  WALTON G. 1951.  SURVEY OF LITERATURE RELATING TO INFANT METHEMOGLOBINEMIA DUE TO NITRATE-CONTAMINATED WATER. AM J PUB
               HEALTH. 41: 986-996.

               US EPA.  1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR NITRITE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

NITROANILINE, M-              000099-09-2
        010023  US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROANILINE (0-, M-, P-). PREPARED BY  THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

        010400  US EPA.  1991.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 3-  NITROANILINE.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.
                                                                                                                                         R1-54

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                                   REFERENCES  FOR HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


NITROANILINE,  0-               000088-74-4
        010022  BIODYNAMICS.  1983a.   A FOUR-WEEK INHALATION  STUDY OF ORTHO-NITROANILINE IN HALE RATS.  FINAL REPORT.   SUBMITTED BY MONSANTO
                CO.

                BIOOYNAMICS.  1983b.   A FOUR-WEEK INHALATION  TOXICITY STUDY OF 0-NITROANILINE IN THE RAT.  FINAL REPORT.  SUBMITTED BY
                MONSANTO CO.

                US  EPA. 1985.  HEALTH  AND ENVIRONMENTAL EFFECTS  PROFILE FOR NITROANILINE (0-, M-, P-). PREPARED BY THE  OFFICE OF HEALTH  AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

                US  EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2-NITROANILINE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

NITROANILINE,  P-               000100-01-6
        010024  US  EPA. 1985.  HEALTH  AND ENVIRONMENTAL EFFECTS  PROFILE FOR NITROANILINE (0-, M-, P-). PREPARED BY THE  OFFICE OF HEALTH  AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

NITROBENZENE                    000098-95-3
        005589  CUT  (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY). 1984. NINETY- DAY  INHALATION STUDY OF NITROBENZENE IN F-344 RATS, CD RATS
                AND B6C3F1 MICE WITH COVER  LETTER DATED 6/24/84  AND EPA RESPONSE DATED 8/06/84,  UNPUBLISHED STUDY. FYI-OTS-0784-0333 AND
                COMPUTER PRINT-OUT OF  PATHOLOGY FINDING.

                US  EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR NITROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.

NITROFURANTOIN                  000067-20-9
        005593  SRI (SOUTHERN RESEARCH INSTITUTE). 1980. SUBCHRONIC TOXICITY REPORT ON NITROFURANTOIN (C55196) IN FISCHER-344 RATS AND B6C3F1
                MICE. TRACOR JIT CO,  INC, ROCKVILLE, MD, CONTRACT NOS N01-CP-  43350 AND 78-65-106002 US EPA.

                US  EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR NITROFURANS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.

NITROGEN  DIOXIDE               010102-44-0
        010402  WALTON G.  1951.  SURVEY OF LITERATURE RELATING  TO INFANT METHEMOGLOBINEMIA DUE  TO  NITRATE-CONTAMINATED WATER.  AM J PUBLIC
                HEALTH. 41: 986-996.

                REFER TO APPENDIX A:  TECHNICAL  INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS

NITROGEN  OXIDES
        910402  REFER TO APPENDIX A:  TECHNICAL  INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS

                                                                                                                                          R1-55

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                                   REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


NITROMETHANE                    000075-52-5
        010026  US EPA. 1985.   HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR  NITROMETHANE.  PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

NITROPHENOLS
        005594  US EPA. 1987.  HEALTH EFFECTS ASSESSMENT  FOR NITROPHENOLS.  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI,  OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE,  WASHINGTON,
                DC.

NITROPROPANE,.2-               000079-46-9
        010374  ANGUS CHEMICAL CO.  1985. FINAL REPORT: CHRONIC INHALATION  EXPOSURE TO RATS TO VAPORS OF 2-NITROPROPANE AT 100 PPM.  PREPARED
                BY COULSTON INTERNATIONAL CORP FOR ANGUS CHEMICAL CO. OTS  NO 204292. DOC NO  8EHQ-0985-0170. FICHE NO 0200504.

                ANGUS CHEMICAL CO.  1985. CHRONIC INHALATION OF 200 PPM OF  2-NITROPROPANE IN  RATS. PREPARED BY COULSTON INTERNATIONAL CORP
                (MAY 1978) FOR ANGUS CHEMICAL CO. OTS  NO 204292. DOC NO 8EHQ-0985-0170.  FICHE NO 0200504

                GRIFFIN TB, F  COULSTON AND AA STEIN. 1980. CHRONIC INHALATION EXPOSURE OF  RATS TO VAPORS OF 2-NITROPROPANE AT 25 PPM.
                ECOTOXICOL ENVIRON  SAF 4(3):267-281.

                GRIFFIN TB, AA STEIN, F COULSTON. 1981.  HISTOLOGICAL STUDY OF TISSUES AND  ORGANS FROM RATS EXPOSED TO VAPORS OF 2-
                NITROPROPANE AT 25  PPM. ECOTOXOCOL ENVIRON SAF 5(2):194-201.

NITROSODIPHENYLAMINE,  P-           000156-10-5
        010027  US EPA. 1986.   HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR  NITROSAMINES.  PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

NITROTOLUENE, M-               000099-08-1
        010029  CISS M, N HUYEN, H  DUTERTRE, N PHU-LICH  AND R TRUHAUT. 1980.  TOX1COLOGICAL STUDY OF NITROTOLUENES: LONG-TERM TOXICITY.
                DAKAR MEDICAL. 25:  293-302.

                US EPA. 1986.   HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR  NITROTOLUENES  (0-, M-, P->. PREPARED  BY THE OFFICE OF HEALTH
                AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE
                AND EMERGENCY  RESPONSE, WASHINGTON,  DC.

NITROTOLUENE, 0-               000088-72-2
        010028  CISS M, N HUYEN, H  DUTERTRE, N PHU-LICH  AND R TRUHAUT. 1980.  TOXICOLOGICAL STUDY OF NITROTOLUENES: LONG-TERM TOXICITY.
                DAKAR MEDICAL. 25:  293-302.

                US EPA. 1986.   HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR  NITROTOLUENES  (0-, M-, P-). PREPARED  BY THE OFFICE OF HEALTH
                AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE
                AND EMERGENCY  RESPONSE, WASHINGTON,  DC.




                                                                                                                                          R1-56

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                                   REFERENCES FOR  HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


NITROTOLUENE,  P-               000099-99-0
        010030  CISS M, N HUYEN,  H DUTERTRE, N PHU-LICH AND R TRUHAUT. 1980. TOXICOLOGICAL STUDY  OF NITROTOLUENES: LONG-TERM TOXICITY.
                DAKAR MEDICAL.  25: 293-302.

                US  EPA. 1986.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROTOLUENES (0-,  M-, P-). PREPARED BY THE OFFICE  OF HEALTH
                AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
                AND EMERGENCY  RESPONSE, WASHINGTON, DC.

OCTABROMODIPHENYL  ETHER           032536-52-0
        010032  CARLSON GP. 1980. INDUCTION OF XENOBIOTIC METABOLISM IN RATS BY BROMINATED DIPHENYL ETHERS ADMINISTERED FOR 90  DAYS.
                TOXICOL LETT.  6:  207-212.

                US  EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL  ETHERS. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

OCTAMETHYLPYROPHOSPHORAMIDE           000152-16-9
        010031  RIDER JA, HC MOELLER, EJ PULETTI AND  JI SWADER. 1969. TOXICITY OF PARATHION, SYSTOX, OCTAMETHYLPYROPHOSPHORAKINE AND METHYL
                PARATHION IN MAN. TOXICOL APPL PHARMACOL. U(3>:  603-611.

                US  EPA. 1989.   HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR OCTAMETHYLPYROPHOSPHORAMINE. PREPARED BY THE OFFICE OF HEALTH
                AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
                AND EMERGENCY  RESPONSE, WASHINGTON, DC.

OZONE                              010028-15-6
        910031  REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

PARALDEHYDE                      000123-63-7
        010033  US  EPA. 1986.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PARALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

PARATHION                        000056-38-2
        005598  US  EPA. 1987.  HEALTH EFFECTS ASSESSMENT FOR PARATHION. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.

PARTICULATE  MATTER
        905598  REFER TO APPENDIX A: TECHNICAL 1NFORMATIO, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

PEBULATE                          001114-71-2
        010036  US  EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PEBULATE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.


                                                                                                                                        R1-57

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                                  REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                        (OTHER  THAN CARCINOGENICITY)                                      January 1992


PENDIMETHALIN                  040487-42-1
        010037  AMERICAN CYANAMID COMPANY.  1979. CONFIDENTIAL BUSINESS  INFORMATION,  UNPUBLISHED STUDY. MRID NO 0058657.

               US EPA.  1984. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE  FOR PENDIMETHALIN. PREPARED  BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE,  WASHINGTON,  DC.

PENTABROMODIPHENYL  ETHER           032534-81-9
        010038  CARLSON  GP. 1980. INDUCTION OF XENOBIOTIC METABOLISM  IN RATS BY 8ROMINATED DIPHENYL ETHERS ADMINISTERED FOR 90 DAYS. TOXICOL
               LETT. 6(3): 207-212.

               US EPA.  1983. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE  FOR BROMINATED  DIPHENYL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY  RESPONSE,  WASHINGTON, DC.

PENTACHLOROBENZENE            000608-93-5
        010039  LINDER R,  T SCOTTI J GOLDSTEIN AND K MCELROY. 1980. ACUTE AND SUBCHRONIC TOXICITY OF PENTACHLOROBENZENE. J ENVIRON  PATHOL
               TOXICOL. 4(5-6): 183-196.

               US EPA.  1989. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR PENTACHLOROBENZENE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY  RESPONSE,  WASHINGTON, DC.

PENTACHLOROCYCLOPENTADIENE          025329-35-5
        005302  US EPA.  1988. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES.  PREPARED  BY THE OFFICE OF HEALTH
               AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND
               EMERGENCY  RESPONSE,  WASHINGTON, DC.

PENTACHLORONITROBENZENE           000082-68-8
        010040  OLIN CORPORATION. 1968. MRID NO. 000114201. US EPA, WASHINGTON, DC.

               US EPA.  1986. HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE  FOR PENTACHLORONITROBENZENE. PREPARED BY THE  OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY  RESPONSE,  WASHINGTON, DC.
                                                                                                                                       R1-58

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                                   REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCIN06ENICITY)                                      January 1992


PENTACHLOROPHENOL              000087-86-5
        005600  SCHWETZ, BA,  JF QUASI, PA KEELER,  ET AL.  1978. RESULTS OF  TWO- YEAR TOXICITY AND REPRODUCTION  STUDIES ON PENTACHLOROPHENOL IN
               RATS. IN: PENTACHLOROPHENOL: CHEMISTRY,  PHARMACOLOGY AND ENVIRONMENTAL TOXICOLOGY, KR RAO,  ED.  PLENUM PRESS, NEW YORK, P 301.
               CITED IN US EPA, 1985.

               US EPA. 1986. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR PENTACHLOROPHENOL. PREPARED BY THE  OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR  THE  OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

               US EPA. 1984. HEALTH  EFFECTS ASSESSMENT  FOR PENTACHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
               DC.

PENTACHLOROPROPENE,  1,1,2,3,3-            001600-37-9
        010041  US EPA. 1983.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR  CHLOROPROPENES. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR  THE  OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

PENTANE,  N-                      000109-66-0
        005603  US EPA. 1987. HEALTH  EFFECTS ASSESSMENT  FOR N-PENTANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
               DC.

PHENANTHRENE                     000085-01-8
        005604  US EPA. 1987. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENANTHRENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

PHENOL                            000108-95-2
        005824  NTP (NATIONAL TOXICOLOGY PROGRAM). 1983.  TERATOLOGIC EVALUATION OF PHENOL IN CD RATS. REPORT PREPARED BY THE RESEARCH
               TRIANGLE INSTITUTE, RESEARCH TRIANGLE PARK, NC. NTIS PB83-247726. GOVT. REP. ANNOUNCE. INDEX 83(25): 6247.

               US EPA. 1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR PHENOL.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
               DC.

PHENYLENEDIAMINE,  M-          000108-45-2
        010044  HOFER H, R HRUBY,  ET  AL. 1982. NINETY-DAY TOXICITY STUDY WITH M- PHENYLENEDIAMINE ON RATS.  OESTRR FORSCHUNGSZENT SEIBERSDORF
               (BER.) OEFZS BER.  NO. 4155. P 50.

               US EPA. 1985. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENYLENEDIAMINES (0-, M-, P-).  PREPARED BY THE OFFICE OF HEALTH
               AND ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR  THE OFFICE OF SOLID WASTE
               AND EMERGENCY RESPONSE, WASHINGTON,  DC.
                                                                                                                                         R1-59

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                        (OTHER THAN  CARCINOGENICITY)                                      January 1992


PHENYLENEDIAMINE,  0-         000095-54-5
        010042  US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  PHENYLENEDIAMINES  (0-, M-, P-).  PREPARED BY THE OFFICE OF
               HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID
               WASTE AND EMERGENCY RESPONSE, WASHINGTON,  DC.

PHENYLENEDIAMINE,  P-         000106-50-3
        010043  NCI.  1979.  BIOASSAY OF P-PHENYLENEDIANINE D1HYDROCHLORIDE  FOR POSSIBLE CARCINOGENICITY.  NCI CARCINOGENESIS TECHNICAL
               REPORT SERIES NO. 174.  46 PP.

               US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  PHENYLENEDIAMINES  (0-, M-, P-).  PREPARED BY THE OFFICE OF
               HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID
               WASTE AND EMERGENCY RESPONSE, WASHINGTON,  DC.

PHENYLMERCURIC  ACETATE       000062-38-4
        010277  FITZHUGH OG, AA NELSON, EP LAUG AND IM KUNZE.  1950. CHRONIC  ORAL TOXICITIES OF MERCURIC PHENYL AND MERCURIC SALTS. ARCH IND
               HYG OCCUP MED.  2: 433-442.

PHORATE                          000298-02-2
        010403  TUSING TW.  1956.  13-WEEK SUBACUTE THIMET FEEDING STUDY IN  MALE AND FEMALE RATS.  UNPUBLISHED REPORT OF THE AMERICAN
               CYANAMID CO. INITIAL SCIENTIFIC AND MINI-ECONOMIC REVIEW OF  PHORATE (THIMET). OFFICE OF PESTICIDE PROGRAMS, US EPA,
               WASHINGTON, DC.

               US EPA.  1985.  SUMMARY OF ACCEPTABLE DAILY INTAKES (ADIS) FOR ORAL EXPOSURE.  PREPARED BY ENVIRONMENTAL CRITERIA AND
               ASSESSMENT OFFICE, CINCINNATI, OH.  INTERNAL REVIEW DRAFT, MAY, 1985.  ECAO- CIN-432.

               NAS (NATIONAL ACADEMY OF SCIENCES).  1977.  DRINKING WATER AND HEALTH.   SAFE DRINKING WATER  COMMITTEE, NATIONAL RESEARCH
               COUNCIL. NAS, WASHINGTON, DC.  P 613-620.

PHOSGENE                         000075-44-5
        010045  US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR  PHOSGENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.
                                                                                                                                        R1-60

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                                   REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


PHOSPHINE                        007803-51-2
        010173  KLIMMER, OR. 1969.  CONTRIBUTION TO THE STUDY OF ACTION OF  PHOSPHINE (PH3).  OH THE QUESTION OF SO-CALLED CHRONIC PHOSPHINE
                POISONING. ARCH TOXICOL 24:164-187.

                US EPA. 1989. HEALTH  AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  PHOSPHINE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

        010174  HACKENBERG, U. 1972.  CHRONIC INGESTION BY  RATS OF STANDARD DIET TREATED WITH ALUMINUM PHOSPHATE. TOXICOL APPL PHARMACOL
                23:147- 158.

                US EPA. 1989. HEALTH  AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  PHOSPHINE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

PHOSPHORUS,  WHITE              007723-14-0
        010452  CONDRAY JR. 1985. ELEMENTAL YELLOW PHOSPHORUS ONE-GENERATION REPRODUCTION STUDY  IN RATS. IR-82-215;  IRD NO. 401-189. MONSANTO
                CO. ST. LOUIS, MO.

PHOTOCHEMICAL OXIDANTS
        010172  US EPA. 1986. AIR QUALITY CRITERIA FOR OZONE AND OTHER PHOTOCHEMICAL OXIDANTS. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, RESEARCH TRIANGLE PARK, NC. EPA  600/8-84-020F. NTIS PB87-142949.

PHTHALIC  ACID,  M-              000121-91-5
        010047  US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  PHTHALIC ACIDS. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

PHTHALIC  ACID,  0-              000088-99-3
        010046  US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  PHTHALIC ACIDS. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

PHTHALIC  ACID,  P-              000100-21-0
        010048  CUT (CHEMICAL INDUSTRY INSTITUTE OF TECHNOLOGY). 1982. A  NINETY- DAY STUDY OF TEREPHTHALIC ACID-INDUCED UROLITHIASIS AND
                REPRODUCTIVE PERFORMANCE IN WISTAR AND CD  RATS. CUT, RESEARCH TRIANGLE PARK,  NC

                GROSS, J.  1974.  THE  EFFECTS OF PROLONGED  FEEDING OF TEREPHTHALIC ACID (TPA) TO  RATS. PROJECT FG-IS-175. AGRICULTURAL
                RESEARCH SERVICE, US  DEPARTMENT OF AGRICULTURE, WASHINGTON,  DC.

                US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR  PHTHALIC ACIDS (0-,  M-, P-). PREPARED BY THE OFFICE OF HEALTH
                AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
                AND EMERGENCY RESPONSE, WASHINGTON,  DC.
                                                                                                                                          R1-61

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                                   REFERENCES  FOR HEAST  TABLE  1: SUBCHRONIC  AND  CHRONIC TOXICITY
                                                        (OTHER THAN  CARCINOGENICITY)                                      January 1992


PHTHALIC  ANHYDRIDE            000085-44-9
        010049  NCI (NATIONAL CANCER INSTITUTE). 1979.   BIOASSAY OF PHTHALIC ANHYDRIDE  FOR POSSIBLE CARCINOGENICITY.  NCI  CARCINOGENESIS
               TECH REP SER NO. 159. NTIS  PB293594.

POLYBROMINATED  BIPHENYLS
        010050  NTP (NATIONAL TOXICOLOGY PROGRAM).  1983.  CARCINOGENESIS  STUDIES OF POLYBROMINATEO BIPHENYL MIXTURE  IN F344/N RATS AND
               B6C3F1 MICE (GAVAGE STUDIES). FIREMASTER FF-1. CASE NO 67774-32-7. NTP, RESEARCH TRIANGLE PARK,  NC.

               US EPA. 1989.  HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR POLYBROMINATED BIPHENYLS. PREPARED  BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

POTASSIUM CYANIDE             000151-50-8
        010278  HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF  FOOD TREATED WITH HYDROGEN CYANIDE.  AGRIC FOOD CHEM. 3: 325-329.

               PHILBRICK DJ, JB HOPKINS, DC HILL, JC ALEXANDER AND RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING
               IN RATS. J TOXICOL ENVIRON  HEALTH. 5: 579-592.

POTASSIUM SILVER CYANIDE    000506-61-6
        010279  HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF  FOOD TREATED WITH HYDROGEN CYANIDE.  AGRIC FOOD CHEM. 3: 325-329.

               PHILBRICK DJ, JB HOPKINS, DC HILL, JC ALEXANDER AND RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING
               IN RATS. J TOXICOL ENVIRON  HEALTH. 5: 579-592.

PROFLURALIN                     026399-36-0
        010051  US EPA. 1984.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR  PROFLURALIN. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE,  WASHINGTON, DC.

PRONAMIDE                       023950-58-5
        010280  ROHM & HAAS, CO. 1970. ACC  NOS 000967, 004417. MRID NOS. 00085508, 00107949, 00133113.

PROPACHLOR                      001918-16-7
        010175  MONSANTO COMPANY. 1964. CONFIDENTIAL BUSINESS INFORMATION  UNPUBLISHED STUDY. MRID NO. 0093270.

               US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPACHLOR.  PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE,  WASHINGTON, DC.

PROPAZINE                       000139-40-2
        010052  CIBA-GEIGY COMPANY.  1980.  CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 243353. MRID NOS. 00041408,
               00076955,  00087893.
                                                                                                                                       R1-62

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                                   REFERENCES FOR  HEAST TABLE  1: SUBCHRONIC  AND  CHRONIC TOXICITY
                                                         (OTHER  THAN CARCINOGENICITY)                                      January 1992


PROPIONITRILE                   000107-12-0
        010053  US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR PROPIONITRILE. PREPARED BY  THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

PROPYL ALCOHOL,  N-             000071-23-8
        005627  US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR N-PROPYL  ALCOHOL. PREPARED  BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

PROPYLENE GLYCOL               000057-55-6
        005629  GUERRANT,  NB,  GP WHITLOCK, ML WOLFF AND RA DUTCHER.  1947.  RESPONSE OF RATS TO DIETS CONTAINING VARYING AMOUNTS OF GLYCEROL
               AND PROPYLENE  GLYCOL. BULL NATL  FORMULARY COMM  15:  204-229. CITED IN INFORMATICS,  INC,  1973.

               US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR PROPYLENE GLYCOL. PREPARED  BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

        005631  GAUNT, IF, RMB CARPANINI, P GRASSO AND ABG LANSDOWN.  1972. LONG- TERM TOXICITY OF PROPYLENE GLYCOL IN RATS. FOOD COSMET
               TOXICOL 10: 151-162.

               US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR PROPYLENE GLYCOL. PREPARED  BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

PROPYLENE GLYCOL MONOETHYL  ETHER             001569-02-4
        005488  SMYTH, HF, JR  AND  CP CARPENTER.  1948. FURTHER EXPERIENCE WITH THE RANGE FINDING TEST IN THE INDUSTRIAL TOXICOLOGY LABORATORY.
               J IND HYG TOXICOL  30:63-68.

               US EPA. 1984.  HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE,
               WASHINGTON, DC. EPA 540/1-86-052.
                                                                                                                                         R1-63

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                                   REFERENCES  FOR HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


PROPYLENE GLYCOL MONOMETHYL  ETHER              000107-98-2
        005486   ROWE, VIC, DD MCCOLLISTER,  HC  SPENCER, ET AL. 1954. TOXICOLOGY OF MONO-, DI-, AND TRI-PROPYLENE GLYCOL METHYL ETHERS. ARCH IND
                HYG OCCUP MED  9:  509-525.

                US EPA. 1984. HEALTH EFFECTS  ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND EMERGENCY RESPONSE,
                WASHINGTON, DC. EPA 540/1-86-052.

        010276   LANDRY TD, TS GUNSHOW AND  BL  YANO. 1983. PROPYLENE GLYCOL MONOMETHYL ETHER: A 13-WEEK INHALATION STUDY IN RATS AND  RABBITS.
                FUND APPL TOXICOL. 3: 627-630

                MILLER RR, EA HERMAN, JT YOUNG, ET AL. 1984. ETHYLENE GLYCOL MONOMETHYL ETHER: METABOLISM, DISPOSITION, AND SUBCHRONIC
                INHALATION TOXICITY STUDIES.  ENVIRON HEALTH PERSPECT. 57: 233-239.

                US EPA. 1984. HEALTH EFFECTS  ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE.
                WASHINGTON, DC. EPA 540/1-86-052.

PROPYLENE OXIDE                000075-56-9
        010375   KUPER CF, PGJ REUZEL, VJ FERON, ET AL. 1988. CHRONIC INHALATION TOXICITY AND CARCINOGENICITY OF PROPYLENE OXIDE IN  WISTAR
                RATS. FOOD CHEM TOXICOL 26(2):159-167.

                US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PROPYLENE OXIDE. PREPARED  BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

PYRENE                            000129-00-0
        010176   US EPA. 1989. MOUSE ORAL SUBCHRONIC  TOXICITY STUDY OF PYRENE. STUDY CONDUCTED BY TOXICITY RESEARCH LABORATORIES, MUSKEGON, MI
                FOR  THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

                US EPA. 1984. HEALTH EFFECTS  ASSESSMENT FOR PYRENE. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.

PYRIDINE                          000110-86-1
        010055   US EPA. 1986. PYRIDINE. 90-DAY SUBCHRONIC ORAL TOXICITY  IN RATS. SPONSORED BY OFFICE  OF SOLID  WASTE AND EMERGENCY RESPONSE,
                WASHINGTON, DC.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PYRIDINE. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON,  DC.
                                                                                                                                           R1-64

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                                   REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January  1992


RDX  (CYCLONITE)                  000121-82-4
        010056  US DEPARTMENT OF DEFENSE.  1983. AD-A160-774.

                US EPA. 1989. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR  RDX  (CYCLONITE). PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

RONNEL                            000299-84-3
        010057  MCCOLLISTER DD, F OYEN AND VK ROWE.   1959.  TOXICOLOGICAL  STUDIES OF 0,0-DIMETHYL-0-(2,4,5-TRICHLOROPHENYL)PHOSPHOTH10ATE
                (RONNEL) IN LABORATORY ANIMALS. J AGRIC FOOD CHEM. 7: 689.

                US EPA. 1984.  HEALTH AND  ENVIRONMENTAL EFFECTS PROFILE FOR  RONNEL. PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL  CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

SELENOUREA                       000630-10-4
        008880  YANG C, S WANG, R ZHOU, AND S SUN. 1983.  ENDEMIC SELENIUM  INTOXICATION OF HUMANS IN CHINA. AM. J.  CLIN. NUTRI. 36:  872-888.

SELENIOUS ACID                  007783-00-8
        010415  YANG C, S YIN, L ZHOU, ET  AL. 1989.  STUDIES OF SAFE MAXIMAL  DAILY DIETARY SE-INTAKE IN A SELENIFERGUS AREA IN CHINA.  II.
                RELATION BETWEEN SE-INTAKE AND THE MANIFESTATION OF CLINICAL SIGNS AND CERTAIN BIOCHEMICAL ALTERATIONS IN BLOOD AND URINE. J.
                TRACE ELEM.   ELECTROLYTE  SHEALTH DIS.  3:  123-130

                US EPA.  1989.  HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT  FOR SELENIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH  AND
                ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND
                EMERGENCY RESPONSE, WASHINGTON DC.

SELENIUM                          007782-49-2
        010404  YANG C, S YIN, L ZHOU, ET  AL.  1989.  STUDIES OF SAFE MAXIMAL DAILY DIETARY SE-INTAKE IN A SELENIFEROUS AREA IN CHINA.   II.
                RELATION BETWEEN SE-INTAKE AND THE MANIFESTATION OF CLINICAL SIGNS AND CERTAIN BIOCHEMICAL ALTERATIONS IN BLOOD AND URINE.
                J TRACE ELEM ELECTROLYTES  HEALTH DIS.  3:  123-130.

                US EPA.  1989.  HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT  FOR SELENIUM AND COMPOUNDS.  PREPARED BY THE OFFICE  OF HEALTH
                AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE
                AND EMERGENCY RESPONSE, WASHINGTON,  DC.

SILVER                            007440-22-4
        010453  GAUL LE AND AN STAUD.  1935. CLINICAL SPECTROSCOPY. SEVENTY CASES OF GENERALIZED  ARGYRIA FOLLOWING ORGANIC AND COLLOIDAL
                SILVER MEDICATION. J AM MED ASSOC. 104: 1387-1390.
                                                                                                                                          R1-65

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                                   REFERENCES FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                        (OTHER THAN  CARCINOGENICITY)                                     January 1992


SILVER CYANIDE                 000506-64-9
        010283  HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY  FOR RATS OF  FOOD TREATED WITH  HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.

               PHILBRICK DJ, JB HOPKINS,  DC  HILL, JC ALEXANDER  AND RG THOMSON. 1979. EFFECTS  OF PROLONGED CYANIDE AND THIOCYAMATE FEEDING
               IN RATS.  J TOXICOL ENVIRON HEALTH. 5: 579-592.

SIMAZINE                         000122-34-9
        010177  CIBA-GEIGY CORPORATION. 1988. MRID N-40614405.

               US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SIMAZINE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE,  WASHINGTON, DC.

SODIUM CYANIDE                 000143-33-9
        005640  HOWARD, JW AND RF HANZAL.  1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. J AGRIC FOOD CHEM  3:
               325-329.

               US EPA. 1984. HEALTH EFFECTS  ASSESSMENT FOR SODIUM CYANIDE.  PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE  OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
               DC.

SODIUM DIETHYLDITHIOCARBAMATE    000148-18-5
        005644  SUNDERMAN, FW, OE PAYNTER  AND RB GEORGE. 1967. THE EFFECTS OF THE PROTRACTED ADMINISTRATION OF THE CHELATING AGENT, SODIUM
               DIETHYLDITHIOCARBAMATE (DITHIOCARB). AM J MED SCI  254: 46-56.

               US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  SODIUM DIETHYLDITHIOCARBAMATE. PREPARED BY THE OFFICE OF HEALTH
               AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE.  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

SODIUM METAVANADATE          013718-26-8
        005735  DOMINGO,  JL, JL LLOBET, JM TOMAS AND J CORBELLA. 1985. SHORT- TERM TOXICITY  STUDIES OF VANADIUM IN RATS. J APPL TOXICOL 5(6):
               418-421.

               US EPA. 1987. HEALTH EFFECTS  ASSESSMENT FOR VANADIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON,  DC.
                                                                                                                                        R1-66

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                                   REFERENCES  FOR  HEAST  TABLE  1: SUBCHRONIC  AND CHRONIC  TOXICITY
                                                         (OTHER  THAN  CARCINOGENICITY)                                      January 1992


STRONTIUM,  STABLE              007440-24-6
        010405  MARIE PJ, MT GARBA,  M  HOTT AND L MIRAVET.  1985.  EFFECT OF  LOW DOSES OF  STABLE STRONTIUM ON BONE METABOLISM  IN RATS.
               MINER ELECTROLYTE  METAB. 11: 5-13.

               US EPA.  1990.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR STABLE STRONTIUM.  PREPARED BY THE OFFICE OF  HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

        010406  SKORYNA SC.  1981.  EFFECTS OF ORAL  SUPPLEMENTATION WITH STABLE STRONTIUM.  CAN MED ASSOC J. 125:703-712.

               US EPA.  1990.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR STABLE STRONTIUM.  PREPARED BY THE OFFICE OF  HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

STRYCHNINE                       000057-24-9
        010285  SEIDL I AND G ZBINDEN. 1982. SUBCHRONIC ORAL TOXICITY OF STRYCHNINE IN RATS.  ARCH TOXICOL. 51(3): 267-271.

STYRENE                           000100-42-5
        010059  QUAST JF, CG HUMISTON, RT KALNINS,  ET  AL.  1979. RESULTS OF A TOXICITY STUDY OF MONOMERIC STYRENE ADMINISTERED TO BEAGLE DOGS
               BY ORAL INTUBATION FOR 19 MONTHS. TOXICOLOGY RESEARCH LABORATORY, HEALTH  AND  ENVIRONMENTAL SCIENCES, DOW CHEMICAL CO.,
               MIDLAND, MI. FINAL REPORT.

               US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STYRENE. PREPARED  BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
               ASSESSMENT,.ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH  FOR  THE OFFICE OF SOLID WASTE, WASHINGTON, DC.

               US EPA. 1989. HEALTH EFFECTS ASSESSMENT FOR STYRENE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI,  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
               DC. ECAO-CIN-H115.

SUCCINONITRILE                  000110-61-2
        005585  US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  SELECTED NITRILES. PRPEPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

SULFUR OXIDES
        910059  REFER TO APPENDIX  A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.

SULFUR DIOXIDES                007446-09-5
        905585  REFER TO APPENDIX  A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
                                                                                                                                         R1-67

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


SULFURIC  ACID                  007664-93-9
        005647 CARSON, BL, BL  HERNOON, HV ELLIS  III, ET AL. 1981.  SULFURIC ACID  HEALTH EFFECTS.  PREPARED UNDER CONTRACT 68-03-2928 BY
               MIDWEST RESEARCH  INSTITUTE, KANSAS CITY, MO.  PREPARED FOR EMISSION CONTROL TECHNOLOGY DIVISION,  OFFICE OF MOBILE  SOURCE AIR
               POLLUTION CONTROL.  US EPA, ANN ARBOR, MI  EPA 460/3-81-025. NTIS PB82-113135.

               US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR SULFURIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE,  WASHINGTON,
               DC.

TEMEPHOS          '               003383-96-8
        010060 GAINES TB, RD KIMBROUGH AND ER LAW, JR.  1967.  TOXICOLOGY OF ABATE IN LABORATORY ANIMALS. ARCH ENVIRON HEALTH.  14: 283-288.

               US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TEMEPHOS. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID  WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

TERBUFOS                           013071-79-9
        010408 MORGAREIDGE K,  S  SISTNER, M DANIELS, ET AL.  1973.  FINAL REPORT: SIX-MONTH FEEDING STUDY IN DOGS ON AC-92,100.  LABORATORY
               NO. 1193. FEBRUARY 14. UNPUBLISHED STUDY. FOOD AND  DRUG LABORATORIES, INC. MRID NO. 41139.

               US EPA. 1987.   HEALTH ASSESSMENT  DOCUMENT FOR  TERBUFOS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE,  WASHINGTON,
               DC.

TEREPHTHALIC  ACID             000100-21-0
        008881  US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TEREPHTHALIC ACID.  PREPARED BY THE OFFICE OF HEALTH  AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

TETRACHLOROAZOXYBENZENE           021232-47-3
        010064 US EPA. 1985.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCAB, TCAOB AND TCHB. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

TETRACHLOROBENZENE,  1,2,4,5-           000095-94-3
        010286 CHU I, DC VILLENEUVE, VE VALLI AND VE SECOURS. 1984. TOXICITY OF  1,2,3,4-, 1,2,3,5- AND 1,2,4,5-TETRACHLOROBENZENE IN THE
               RAT: RESULTS OF A 90-DAY FEEDING  STUDY. DRUG CHEM TOXICOL. 7:  113-127.

TETRACHLOROCYCLOPENTADIENE          000695-77-2
        005303 US EPA. 1988.   HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES.  PREPARED BY
               THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT.  ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH  FOR
               THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON,  DC.
                                                                                                                                        R1-68

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                                  REFERENCES  FOR HEAST TABLE 1:  SUBCHRONIC  AND  CHRONIC  TOXICITY
                                                       (OTHER THAN  CARCINOGENICITY)                                     January 1992


TETRACHLOROETHANE,  1,1,1,2-           000630-20-6
        010407  NTP (NATIONAL TOXICOLOGY PROGRAM).  1983.  CARCINOGENESIS STUDIES OF 1,1,1,2-TETRACHLOROETHANE IN F344/N RATS AND B6C3F1
               MICE.  NTP,  WASHINGTON, DC.

TETRACHLOROETHYLENE          000127-18-4
        005650  BUBEN, JA, EJ 0'FLAHERTY. 1985. DELINEATION OF THE  ROLE OF METABOLISM IN  THE HEPATOTOXICITY OF TRICHLOROETHYLENE AND
               PERCHLOROETHYLENE: A DOSE-EFFECT STUDY.  TOXICOL APPL PHARMACOL 78:105-122.

TETRACHLOROHYDRAZOBENZENE          071753-42-9
        010065  US EPA. 1985.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR TCAB, TCAOB AND TCHB. PREPARED BY  THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

TETRACHLOROPHENOL,  2,3,4,6-           000058-90-2
        005323  US EPA. 1986. 2,3,4,6-TETRACHLOROPHENOL.  90-DAY SUBCHRONIC ORAL TOXICITY  STUDY IN  RATS. OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

TETRACHLOROPHENOL,  2,3,4,5-           004901-51-3
        005324  US EPA. 1987.  HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR CHLOROINATED  PHENOLS.  PREPARED BY
               THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE, CINCINNATI, OH FOR
               THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE, WASHINGTON, DC.

TETRACHLOROPHENOL,  2,3,5,6-           000935-95-5
        005325  US EPA. 1987.  HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR CHLORINATED  PHENOLS.   PREPARED BY
               THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE, CINCINNATI, OH FOR
               THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE, WASHINGTON, DC.

TETRACHLOROPROPENE,  1,1,2,3-           010436-39-2
        010066  US EPA.  1983.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES.  PREPARED BY THE  OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

TETRACHLORVINPHOS             000961-11-5
        010067  SHELL CHEMICAL COMPANY. 1968. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION  NO 115684.

               US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STIROFOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.

TETRAETHYL DITHIOPYROPHOSPHATE          003689-24-5
        010287  KIMMERLE G AND OR  KLIMMER. 1974. ACUTE AND SUBCHRONIC TOXICITY OF SULFOTEP. ARCH TOXICOL. 33(1): 1-16.
                                                                                                                                    R1-69

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                                   REFERENCES  FOR HEAST TABLE 1:  SUBCHRONIC  AND  CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)
                                                                                                January 1992
THALLIC  OXIDE                   001314-32-5
        005660  US EPA. 1986. SUBCHRONIC  (90 DAY) TOXICITY OF  THALLIUM (I) SULFATE  (CAS NO. 7446-18-6)  IN SPRAGUE-DAULEY RATS.   FINAL REPORT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE,  WASHINGTON, DC.

                US EPA. 1988. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,   WASHINGTON, DC.

THALLIUM (I) ACETATE          000563-68-8
        005664  US EPA. 1986. SUBCHRONIC  (90 DAY) TOXICITY OF  THALLIUM (I) SULFATE  (CAS NO. 7446-18-6)  IN SPRAGUE-DAWLEY RATS.   FINAL REPORT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE,  WASHINGTON, DC.

                US EPA. 1988. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,   WASHINGTON, DC.

THALLIUM (I) CARBONATE       006533-73-9
        005668  US EPA. 1986. SUBCHRONIC  (90 DAY) TOXICITY OF  THALLIUM (I) SULFATE  (CAS NO. 7446-18-6)  IN SPRAGUE-DAWLEY RATS.   FINAL REPORT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE,  WASHINGTON, DC.

                US EPA. 1988. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,   WASHINGTON, DC.

THALLIUM (I) CHLORIDE        007791-12-0
        005672  US EPA. 1986. SUBCHRONIC  (90 DAY) TOXICITY OF  THALLIUM (I) SULFATE  (CAS NO. 7446-18-6)  IN SPRAGUE-DAWLEY RATS.   FINAL REPORT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH OFFICE OF SOLID WASTE AND  EMERGENCY RESPONSE,  WASHINGTON, DC.

                US EPA. 1988. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,   WASHINGTON, DC.

THALLIUM (IN SOLUBLE  SALTS)
        010458  US EPA. 1988. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,   WASHINGTON, DC.
THALLIUM(I)  NITRATE
010102-45-1
        005676   US EPA.  1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CAS NO. 7446-18-6)  IN  SPRAGUE-DAWLEY RATS.   FINAL
                REPORT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH OFFICE OF SOLID WASTE  AND EMERGENCY RESPONSE,
                WASHINGTON, DC.

                US  EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR  THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.
                                                                                                                                          R1-70

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                                   REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND CHRONIC TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January  1992


THALLIUM SELENITE              012039-52-0
        005680  US EPA. 1986. SUBCHRONIC  (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CAS NO.  7446-18-6) IN SPRAGUE-DAWLEY RATS.   FINAL REPORT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE,  WASHINGTON, DC.

                US EPA. 1988. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND
                EMERGENCY RESPONSE,   WASHINGTON, DC.

THALLIUM (I) SULFATE          007446-18-6
        005682  US EPA. 1986. SUBCHRONIC  (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CAS NO.  7446-18-6) IN SPRAGUE-DAWLEY RATS.   FINAL REPORT.
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE,  WASHINGTON, DC.

                US EPA. 1988. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND
                EMERGENCY RESPONSE,   WASHINGTON, DC.

THIOCYANOMETHYLTHIO)-BENZOTHIAZOLE,2-(  (TCMTB)            021564-17-0
        010068  US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCMTB. PREPARED  BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND  EMERGENCY
                RESPONSE, WASHINGTON,  DC.

THIOFANOX                        039196-18-4
        010069  US EPA. 1989.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THIOFANOX. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND  EMERGENCY
                RESPONSE, WASHINGTON,  DC.

THIRAM                            000137-26-8
        010070  HORNSHAW TC, RJ AULERICH  AND RK RINGER.  1987.  TOXICITY OF THIRAM (TETRAMETHYLTHINORAM DISULFIDE) TO MINK AND  EUROPEAN
                FERRETS. BULL ENVIRON CONTAM TOXICOL. 38(4): 618-626.

                US EPA. 1989. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR THIRAM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL'CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID  WASTE AND  EMERGENCY
                RESPONSE, WASHINGTON,  DC.

        010459  E.I. DU PONT DE NEMOURS AND COMPANY, INC. 1954. MRID NO. 0045162.

TIN AND  COMPOUNDS
        005688  NTP  (NATIONAL TOXICOLOGY  PROGRAM). 1982.  CARCINOGENESIS BIOASSAY OF STANNOUS CHLORIDE (CAS NO 7772-99-8) IN F344/N  RATS AND
                B6C3F1/N MICE (FEED  STUDY). NCI/NTP TECH REP SER NO 231. ALSO PUBL AS DHHS (NIH) PUBL ISS NIH 82-1787 AND NTIS  PB 82-242-553

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR TIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL
                CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
                                                                                                                                          R1-71

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC  AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                      January 1992


TOLUENE                           000108-88-3
        005915   ANDERSEN I, GR LUNDOVIST,  L MOLHAVE, ET AL.  1983. HUMAN RESPONSE TO CONTROLLED LEVELS OF TOLUENE  IN SIX-HOUR EXPOSURE.
                SCAND J WORK ENVIRON HEALTH 9:405-418.

                CUT (CHEMICAL INDUSTRY  INSTITUTE OF TOXICOLOGY). 1980. A TWENTY-FOUR MONTH INHALATION TOXICOLOGY STUDY IN FISCHER-344 RATS
                EXPOSED TO ATMOSPHERIC TOLUENE. EXECUTIVE SUMMARY AND DATA TABLES.  EXECUTIVE SUMMARY AND DATA  TABLES. OCTOBER 15,  1980.
                CITED IN US EPA,  1985.

                US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR  TOLUENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,  WASHINGTON,
                DC.

        010469   NTP (NATIONAL TOXICOLOGY PROGRAM). 1989. TOXICOLOGY AND CARCINOGENESIS STUDIES OF TOLUENE IN F344 RATS AND B6C3F1  MICE.
                TECHNICAL REPORT  SERIES NO 371.

                US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR  TOLUENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,  WASHINGTON,
                DC.

        905915   FOO, S, J JEYARATNAM AND D KOH. 1990. CHRONIC  NEUROBEHAVIORAL EFFECTS OF TOLUENE. BR. J. IND.  MED. 47(7): 480-484.

                NTP. 1990. TOXICOLOGY AND  CARCINOGENESIS STUDIES OF TOLUENE IN F344/N RATS AND B6C3F1 MICE (INHALATION STUDIES). NTP TR 371.
                253 P.

TOLUENE-2,3-DIAMINE           002687-25-4
        010071   US EPA. 1984.  HEALTH AND  ENVIRONMENTAL EFFECTS  PROFILE FOR SELECTED TOLUENEDIAMINES. PREPARED BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

TOLUENE-2,5-DIAMINE           000095-70-5
        010073   NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY  OF TOLUENE-2,5- DIAMINE SULFATE FOR  POSSIBLE CARCINOGENICITY. NCI
                CARCINOGENESIS TECH  REP SER NO  126.

                US EPA. 1984.  HEALTH AND  ENVIRONMENTAL EFFECTS  PROFILE FOR SELECTED TOLUENEDIAMINES. PREPARED BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

TOLUENE-2,6-DIAMINE           000823-40-5
        010074   NCI (NATIONAL CANCER INSTITUTE). 1980. BIOASSAY  OF 2,6- TOLUENEDIAMINE DIHYDROCHLORIDE FOR POSSIBLE CARCINOGENICITY. NCI
                CARCINOGENESIS TECH  REP SER NO  200.

                US EPA. 1984.  HEALTH AND  ENVIRONMENTAL EFFECTS  PROFILE FOR SELECTED TOLUENEDIAMINES. PREPARED BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.



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                                   REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC AND  CHRONIC  TOXICITY
                                                        (OTHER  THAN CARCINOGENICITY)                                     January 1992


TOLUENE-3.4-DIAMINE          000496-72-0
        010072 US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR SELECTED TOLUENEDIAMINES. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

TOLUIDINE, M-                  000108-44-1
        010075 US EPA. 1984.   HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR TOLUIDINES. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE AND  EMERGENCY
               RESPONSE, WASHINGTON, DC.

TRIALLATE                       002303-17-5
        010076 MONSANTO COMPANY. 1979.  CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 242057.

TRIBROMOBENZENE,   1,2,4-     000615-54-3
        010077 CARLSON GP AND RG TARDIFF.  1977. EFFECT OF  1,4-DIBROMODIBENZENE AND 1,2,4-TRIBROMOBENZENE ON XENOBIOTIC METABOLISM. TOX1COL
               APPL PHARMACOL. 42: 189-196.

               US EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOBENZENES. PREPARED  BY THE OFFICE OF HEALTH  AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
               AND EMERGENCY  RESPONSE,  WASHINGTON,  DC.

TRICHLOROBENZENE,  1,2,4-    000120-82-1
        008885 ROBINSON KS, RJ KAVLOCK. N  CHERNOFF  AND E GRAY. 1981. MULT I GENERATION STUDY OF  TRICHLOROBENZENE IN RATS. J. TOXICOL. ENVIRON.
               HEALTH. 8:489-500.

TRICHLOROCYCLOPENTADIENE           077323-84-3
        005304 US EPA. 1988.   HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES.  PREPARED BY
               THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR
               THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON,  DC.

TRICHLOROETHANE,   1,1,1-           000071-55-6
        005700 TORKELSON. RR,  F OYEN,  DD MCCOLLISTER AND VK ROWE. 1958. TOXICITY  OF 1,1,1-TRICHLOROETHANE AS  DETERMINED ON LABORATORY
               ANIMALS AND  HUMAN SUBJECTS. AM  IND HYG ASSOC J  19: 353-362.

               US EPA. 1984.  HEALTH EFFECTS ASSESSMENT FOR 1,1,1-TRICHLOROETHANE. PREPARED BY  THE  OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON,  DC.

TRICHLOROETHANE,   1,1,2-           000079-00-5
        005702 WHITE,  KL JR,  VM SANDERS, VW BARNES, GM SHOPP AND AE  MUNSON. 1985. TOXICOLOGY OF  1,1,2 TRICHLOROETHANE IN THE MOUSE. DRUG
               CHEM TOXICOL  8(5): 333-355.

               SANDERS, VM, KL WHITE JR, GM SHOPP JR AND AE MUNSON.  1985. HUMORAL AND CELL MEDIATED IMMUNE STATUS OF MICE  EXPOSED TO 1,1,2
               TRICHLOROETHANE. DRUG CHEM  TOXICOL 8(5): 357-372.


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                                   REFERENCES  FOR HEAST TABLE  1: SUBCHRONIC  AND CHRONIC TOXICITY
                                                        (OTHER THAN  CARCINOGEN I CITY)                                     January 1992


TRICHLOROFLUOROMETHANE           000075-69-4
        005502  NCI  (NATIONAL CANCER INSTITUTE). 1978.  BIOASSAY OF TRICHLOROFLUOROMETHANE FOR POSSIBLE  CARCINOGENICITY.  NCI CARCINOGENESIS
        005500  TECH REP SER NO 106. ALSO PUBL AS DHEW (NIH>  78-1356.

               US EPA. 1987. HEALTH EFFECTS ASSESSMENT  FOR FULLY HALOGENATED METHANES.  PREPARED BY THE  OFFICE OF HEALTH  AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE  OF EMERGENCY AND  REMEDIAL RESPONSE,
               WASHINGTON, DC.

TRICHLORO-2'-HYDROXYDIPHENYL  ETHER,  2,4,4'-   003380-34-5
        005492  LYMAN, FL AND T FURIA. 1969. TOXICOLOGY  OF  2,4,4'-TRICHLORO-2'- HYDROXYDIPHENYL ETHER.  IND MED  38:  45-52.

               US EPA. 1987. HEALTH EFFECTS AND ENVIRONMENTAL DOCUMENT FOR  HALOETHERS.  PREPARED BY THE  OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE, WASHINGTON, DC.

TRICHLOROPHENOL,  2,3,4-           015950-66-0
        005330  US EPA. 1987.  HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR CHLORINATED PHENOLS.  PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH  FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

TRICHLOROPHENOL,  2,3,5-           000933-78-8
        005331  US EPA. 1987.  HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR CHLORINATED PHENOLS.  PREPARED BY
               THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR
               THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE, WASHINGTON, DC.

TRICHLOROPHENOL,  2,3,6-           000933-75-5
        005332  US EPA. 1987.  HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR CHLORINATED PHENOLS.  PREPARED BY
               THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR
               THE OFFICE OF SOLID WASTE AND EMERGENCY  RESPONSE, WASHINGTON, DC.

TRICHLOROPHENOL,  2,4,5-           000095-95-4
        005329  MCCOLLISTER, DD, DT LOCKWOOD AND VK ROWE.  1961. TOXICOLOGIC  INFORMATION  ON 2,4,5-TRICHLOROPHENOL. TOXICOL APPL PHARMACOL
               3:63-70.

               US EPA. 1984. HEALTH EFFECTS ASSESSMENT  FOR 2,4,5- TRICHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE  OF EMERGENCY AND  REMEDIAL RESPONSE,
               WASHINGTON, DC.

               US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  CHLORINATED  PHENOLS. PREPARED BY THE OFFICE OF  HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH  FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.
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                                   REFERENCES FOR HEAST  TABLE  1:  SUBCHRONIC  AND CHRONIC TOXICITY
                                                        (OTHER THAN  CARCINOGENICITY)                                     January 1992


TRICHLOROPHENOL,  2,4,6-          000088-06-2
        010461  US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  CHLORINATED  PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH  FOR THE OFFICE OF  SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON, DC.

TRICHLOROPHENOL,  3,4,5-          000609-19-8
        005333  US EPA. 1987.   HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS.  PREPARED BY
               THE OFFICE OF  HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR
               THE OFFICE OF  SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

TRICHLOROPHENOXYJPROPIONIC ACID,  2(2,4,5-           000093-72-1
        010284  GEHRING PJ AND JE BETSO. 1978. PHENOXY ACIDS: EFFECTS AND  FATE IN MAMMALS.  IN: CHLORINATED PHENOXY ACIDS  AND THEIR DIOXINS,
               VOL 27. C RAMEL ED. ECOL BULL, STOCKHOLM. P.  122-133

               MULLISON WR. 1966. SOME TOXICOLOGICAL ASPECTS OF SILVEX. IN: PROC 19TH ANN MEET SOUTHERN WEED CONFERENCE, JACKSONVILLE, FL.
               P. 420-435.

TRICHLOROPHENOXYACETIC ACID,  2,4,5-           000093-76-5
        010178  KOCIBA, RS, DG KEYES, RW LISOWE, ET AL. 1979. RESULTS OF 2-YEAR CHRONIC  TOXICITY AND ONCOGENICITY STUDY OF RATS INGESTING
               DIETS CONTAINING 2,4,5-T. FOOD COSMET TOXICOL 17:205-222.

               SMITH FA, FJ MURRAY, JA JOHN, ET AL. 1981.  THREE-GENERATION  REPRODUCTION STUDY OF RATS  INGESTING 2,4,5-TRICHLOROPHENOXYACETIC
               ACID IN THE DIET. TOXICO. RES. LAB., DOW CHEMICAL, MIDLAND,  MI.

               US EPA. 1989.  HEALTH EFFECTS ASSESSMENT FOR 2,4,5-TRICHLOROPHENOXY ACETIC ACID. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH  FOR THE OFFICE OF  EMERGENCY AND
               REMEDIAL RESPONSE, WASHINGTON, DC.

        010179  GEHRING,  PJ, AND JE BETSO. 1978. PHENOXY ACIDS: EFFECTS AND  FATE IN MAMMALS. ECO BULL 27:122-123.

               US EPA. 1989.  HEALTH EFFECTS ASSESSMENT FOR 2,4,5-TRICHLOROPHENOXYACETIC ACID. PREPARED BY THE OFFICE OF  HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH  FOR THE OFFICE OF  EMERGENCY AND
               REMEDIAL RESPONSE, WASHINGTON, DC.

TRICHLOROPROPANE,  1,1,1-           007789-89-1
        005705  US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR  TRICHLOROPROPANES. PREPARED BY THE OFFICE OF  HEALTH AND
               ENVIRONMENTAL  SSESSMENT ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.
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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                         (OTHER  THAN CARCINOGENICITY)                                      January 1992


TRICHLOROPROPANE,  1,1,2-           000598-77-6
        005708  VILLANEUVE,  DC,  I CHU, VE SECOURS. HG COTIE, GL PLAA  AND VE VALLI.  1985. RESULTS OF A 90-DAY TOXICITY  STUDY ON 1,2,3- AND
               1,1,2-TRICHLOROPROPANE ADMINISTERED VIA THE DRINKING  WATER. SCI  TOTAL ENVIRON  47:  421-426.

               US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROPROPANES.  PREPARED BY THE OFFICE  OF  HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE  OF  SOLID WASTE AND
               EMERGENCY RESPONSE,  WASHINGTON,  DC.

TRICHLOROPROPANE,  1,2,2-           003175-23-3
        005706  US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROPROPANES.  PREPARED BY THE OFFICE  OF  HEALTH AND
               ENVIRONMENTAL  ASSESSMENT ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

TRICHLOROPROPANE,  1,2,3-           000096-18-4
        005714  NTP (NATIONAL  TOXICOLOGY PROGRAM). 1983. FINAL REPORT 120-DAY TOXICITY GAVAGE STUDY OF 1,2,3-TRICHLOROPROPANE IN FISCHER 344
               RATS. PERFORMED  BY HAZELTON LABORATORIES.

               US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROPROPANES.  PREPARED BY THE OFFICE  OF  HEALTH AND
               ENVIRONMENTAL  ASSESSMENT ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

TRICHLOROPROPENE,  1,2,3-           000096-19-5
        010078  MCKENNA MJ,  JF QUASI AND GA STEVENS.  1978.  RESULTS  OF A 90-DAY INHALATION TOXICITY STUDY OF 1,2,3-TRICHLOROPROPENE  IN
               LABORATORY ANIMALS. TOXICOL APPL  PHARMACOL. 45: 249.

               US EPA. 1983.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES. PREPARED BY THE OFFICE OF  HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE  OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

TRICHLOROTOLUENE,  ALPHA,2,6-           002014-83-7
        005339  CHU, I, SY SHEN,  DC VILLENEUVE, VE SECOURS AND VE VALLI. 1984. TOXICITY OF TRICHLOROTOLUENE ISOMERS:   A 28-DAY FEEDING STUDY
               IN THE RAT.  J  ENVIRON SCI HEALTH  PART B PESTIC FOOD CONTAM AGRIC WASTES 19(2):183-192.

               US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED TOLUENES. PREPARED BY THE OFFICE  OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE  OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.

TRICHLOROTOLUENE,  2,3,6-           002077-46-5
        005335  CHU, I, SY SHEN,  DC VILLENEUVE, VE SECOURS AND VE VALLI. 1984. TOXICITY OF TRICHLOROTOLUENE ISOMERS:   A 28-DAY FEEDING STUDY
               IN THE RAT.  J  ENVIRON SCI HEALTH  PART B PESTIC FOOD CONTAM AGRIC WASTES 19(2):183-192.

               US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED TOLUENES. PREPARED BY THE OFFICE  OF HEALTH AND
               ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE  OF  SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON, DC.



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                                                         (OTHER  THAN  CARCINOGENICITY)                                      January 1992


TRICHLORO-1,2,2-TRIFLUOROETHANE,  1,1,2-   000076-13-1
        010376  TROCHIMOWICZ HJ,  GM  RUSCH, T CHIU,  ET AL. 1988. CHRONIC  INHALATION TOXICITY/CARCINOGENICITY STUDY IN RATS EXPOSED TO
                FLUOROCAR80N 113  (FC-113). FUND APPL TOXICOL 11(1):68-75.

                US  EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR  1,1,2- TRICHLORO-1,2,2-TRIFLUOROETHANE.  PREPARED BY THE OFFICE
                OF  HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF
                SOLID WASTE AND EMERGENCY RESPONSE,  WASHINGTON, DC.

        010460  INBUS HR AND C ATKINS.  1972. PHYSICAL EXAMINATION OF  WORKERS EXPOSED TO  TRICHLOROTRIFLUOROETHANE. ARCH. ENVIRON. HEALTH.
                24(4): 257-261.

TRIFLURALIN                     001582-09-8
        010080  HOECHST AKTIENGESELLSCHAFT.  1984.   CONFIDENTIAL BUSINESS  INFORMATION, UNPUBLISHED  STUDY. MRID NO 00151908.

                US  EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIFLURALIN.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

TRIMETHYLBENZENES
        005727  US  EPA.  1987. HEALTH  AND ENVIRONMENTAL ASSESSMENT,  FOR TRIMETHYLBENZENES.  PREPARED  BY
                THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,
                CINCINNATI, OH FOR THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC.

TRINITROBENZENE,  1,3,5-           000099-35-4
        010081   CODY TE, S WITHERUP, L  HASTINGS, K  STEMMER AND RT CHUSTION.  1981. 1,3-DINITROBENZENE:  TOXIC EFFECTS  IN VITRO. J TOXICOL
                ENVIRON HEALTH. 7: 829-847.

                US  EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR  1,3,5-TRINITROBENZENE.  PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

TRINITROPHENOLS
        010082  US  EPA. 1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR  TRINITROPHENOLS. PREPARED  BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

TRINITROPHENYLMETHYLNITRAMINE           000479-45-8
        010377  FATI S, E DANIELE. 1965. HISTOPATHOLOGICAL CHANCES  IN EXPERIMENTAL CHRONIC TETRYL POISONING. FOLIA MED 48(4):269-276.

                US  EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR  TRINITROPHENYLMETHYLNITRAMINE. PREPARED  BY THE OFFICE OF HEALTH
                AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
                AND EMERGENCY RESPONSE, WASHINGTON,  DC.
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                                   REFERENCES FOR  HEAST  TABLE  1: SUBCHRONIC  AND CHRONIC TOXICITY
                                                         (OTHER  THAN  CARCINOGENICITY)                                      January 1992


TRINITROTOLUENE, 2,4,6-           000118-96-7
        010416  US DOO (DEPARTMENT OF DEFENSE).   1983.  AD-A157-002.   DEFENSE TECHNICAL  CENTER, CAMERON STATION, ALEXANDRIA,  VA.

               US EPA.  1990.   HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT  FOR 2,4,6-TRINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON DC.

VANADIUM                          007440-62-2
        005739  SCHROEDER, HA,  M MITCHENER AND AP NASON. .1970. ZIRCONIUM,  NIOBIUM, ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES. J. NUTR.
               100: 59-69.

               US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR VANADIUM  AND COMPOUNDS. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON, DC.

VANADIUM  PENTOXIDE           001314-62-1
        005743  STOKINGER, HE,  WD WAGNER, JT MOUNTAIN, ET AL. 1953. UNPUBLISHED RESULTS. DIV OCCUP HEALTH,  CINCINNATI, OH. CITED IN
               STOKINGER, 1981.

               US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR VANADIUM  AND COMPOUNDS. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON, DC.

VANADYL SULFATE                027774-13-6
        008886  SCHROEDER, HA,  M MITCHENER AND AP NASON.  1970. ZIRCONIUM,  NIOBIUM, ANTIMONY AND LEAD IN RATS: LIFE-TIME STUDIES. J. NUTR.
               100: 59-69.

               US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR VANADIUM  AND COMPOUNDS. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON, DC.

VERNAM                            001929-77-7
        010083  STAUFFER CHEMICAL COMPANY. 1983. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NOS 249703-249704.

               US EPA. 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR VERNOLATE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF  SOLID WASTE AND EMERGENCY
               RESPONSE, WASHINGTON, DC.
                                                                                                                                         R1-78

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                                    REFERENCES  FOR HEAST TABLE  1:  SUBCHRONIC AND  CHRONIC TOXICITY
                                                          (OTHER THAN  CARCINOGENICITY)                                       January  1992


VINYL ACETATE                  000108-05-4
        010417  SHAW DC.   1988.  VINYL ACETATE: 104-WEEK ORAL (DRINKING WATER)  COMBINED CHRONIC TOXICITY AND CARCINOGENICITY  STUDY  IN THE
                RAT FOLLOWING  IN VITRO EXPOSURE,  VOLUME  i.  HAZELETON LABORATORIES, UK. REPORT NO. 5531-5/16. EPA DOC. NO.  86-0000265. FICHE
                NO OTS0514156.

                US EPA.   1989.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR VINYL ACETATE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR  THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON DC.

        010418  OWEN, PE.  1988.  VINYL ACETATE:  104 WEEK INHALATION COMBINED CHRONIC TOXICITY AND  CARCINOGENICITY STUDY IN THE RAT AND
                MOUSE.  REPORT PREPARED BY HAZELTON LABORATORIES EUROPE, LTD., HARROGATE, ENGLAND FOR THE SOCIETY OF THE PLASTICS INDUSTRY,
                INC., NEW YORK. REPORT NO. 5547-51/15. NOVEMBER, 1988.

                BEEMS,  RB.   1988.  REPORT NO V88-133:  HISTOPATHOLOGY OF THE  RESPIRATORY TRACT OF MICE USED  IN A 104-WEEK INHALATION STUDY
                (OWEN,  1988) WITH VINYL ACETATE.   (TNO-  CIVO INSTITUTES, APRIL, 1988).

                DREEF,  VAN DER MEULEN, HC. 1988.  REPORT  NO. V88, 033/270836: HISTOPATHOLOGY OF THE  RESPIRATORY TRACT OF RATS  USED IN A 104
                WEEK INHALATION STUDY (OWEN, 1988) WITH  VINYL ACETATE: REVISED  VERSION (TNO-CIVO INSTITUTES, OCTOBER, 1988).

VINYL-1-CYCLOHEXENE, 1-      000100-40-3
        010084  US EPA.  1983.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR  4-  VINYL-1-CYCLOHEXENE.  PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR  THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

WARFARIN                          000081-81-2
        010409  HUFF, SB, EO. 1985. PHYSICIANS DESK  REFERENCE, 39TH ED. MEDICAL ECONOMICS CO, INC,  ORADELL, NJ.

XYLENE,  M-                        000108-38-3
        010468  HAKE CL,  RD STEWART, A WU, ET AL. 1981.  DEVELOPMENT OF A BIOLOGIC STANDARD FOR THE  INDUSTRIAL WORKER BY BREATH ANALYSIS.
                NIOSH-MCOW- ENUM-XY-77-3. NTIS-PB82-152844.

                US EPA.  1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR XYLENES. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI,  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

        005755  NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND  CARCINOGENESIS OF XYLENES (MIXED) (60.2%
                M- XYLENE,  13.6% P-XYLENE, 17.0% ETHYLBENZENE AND 9.1% 0-XYLENE) (CAS NO. 1330-20-7) IN F344/N RATS AND B6C3F1 MICE (GAVAGE
                STUDIES). US DHHS, PHS, NIH, NTP, RESEARCH  TRIANGLE PARK,  NC, NTP TR 327, NIH PUBL  NO 86-2583.

                US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR XYLENES (0-, M-, P-). PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR  THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.
                                                                                                                                            R1-79

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                                    REFERENCES  FOR HEAST  TABLE  1:  SUBCHRONIC  AND CHRONIC  TOXICITY
                                                          (OTHER THAN  CARCINOGENICITY)                                      January 1992


XYLENE,  MIXTURE                001330-20-7
        005763  NTP (NATIONAL TOXICOLOGY PROGRAM).  1986.  NTP TECHNICAL REPORT  ON  THE  TOXICOLOGY AND CARCINOGENESIS OF XYLENES (MIXED) (60.2%
                M-XYLENE,  13.6% P-XYLENE, 17.0% ETHYLBENZENE AND 9.1% 0-XYLENE)   (CAS NO. 1330-20-7) IN F344/N RATS AND B6C3F1 MICE (GAVAGE
                STUDIES).  US DHHS, PHS, NIH, NTP,  RESEARCH TRIANGLE PARK,  NC,  NTP  TR 327, NIH PUBL NO 86-2583.

                US EPA.  1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR XYLENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR  THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

        005918  HAKE CL, RD STEWARD, A WU, ET AL.  1981.  DEVELOPMENT OF A BIOLOGIC STANDARD FOR THE INDUSTRIAL WORKER BY BREATH ANALYSIS.
                NIOSH-MCOW-ENUM-XY-77-3. NTIS PB82-152844.

                US EPA.  1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR XYLENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR  THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

XYLENE,  0-                       000095-47-6
        010467  HAKE CL, RD STEWART, A WU, ET AL.  1981.  DEVELOPMENT OF A BIOLOGIC STANDARD FOR THE INDUSTRIAL WORKER BY BREATH ANALYSIS.
                NIOSH-MCOW- ENUM-XY-77-3. NTIS PB82-152844.

                US EPA.  1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR XYLENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR  THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

        005751  NTP (NATIONAL TOXICOLOGY PROGRAM).  1986.  NTP TECHNICAL REPORT  ON  THE  TOXICOLOGY AND CARCINOGENESIS OF XYLENES (MIXED) (60.2%
                M- XYLENE, 13.6% P-XYLENE, 17.0% ETHYLBENZENE AND 9.1% 0-XYLENE)  (CAS NO. 1330-20-7) IN F344/N RATS AND B6C3F1 MICE (GAVAGE
                STUDIES).  US DHHS, PHS, NIH, NTP,  RESEARCH TRIANGLE PARK,  NC,  NTP TR  327, NIH PUBL NO 86-2583.

                US EPA.  1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR XYLENES  (0-, M-, P-). PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY  RESPONSE, WASHINGTON, DC.

XYLENE,  P-                       000106-42-3
        010378  HAKE CL, RD STEWART, A WU, ET AL.  1981.  DEVELOPMENT OF A BIOLOGIC STANDARD FOR THE INDUSTRIAL WORKER BY BREATH ANALYSIS.
                NIOSH-MCOW- ENUM-XY-77-3. NTIS PB82-152844.

                US EPA.  1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR XYLENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR  THE  OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
                WASHINGTON, DC.
                                                                                                                                            R1-80

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                                   REFERENCES FOR HEAST TABLE 1:  SUBCHRONIC AND CHRONIC  TOXICITY
                                                         (OTHER THAN  CARCINOGENICITY)                                     January 1992


ZINC  (METALLIC)                007440-66-6
        005767  PRASAD, AS, EB SCHOOMAKER, J ORTEGA, ET AL. 1975. ZINC DEFICIENCY  IN SICKLE CELL DISEASE. CLIN CHEM  21:582-587. PORIES,  WJ,
                JH HENZEL, CG ROB AND UH STRAIN.  1967. ACCELERATION OF WOUND HEALING IN HAN WITH ZINC SULFATE  GIVEN BY MOUTH.  LANCET
                1:121-124.

                US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR ZINC. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.

ZINC  CYANIDE                   000557-21-1
        010289  HOWARD JW AND RF HANZAL. 1955.  CHRONIC TOXICITY  FOR RATS OF  FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.
                PHILBRICK DJ, JB HOPKINS, DC HILL, JC ALEXANDER  AND RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING
                IN RATS. J TOXICOL ENVIRON HEALTH. 5: 579-592.

ZINC  PHOSPHIDE                 001314-84-7
        010290  BAI KM, MK KRISHNAKUMARI, JP RAMESH, T SHIVANANDAPPA AND SK  MAJUNDER. 1980. SHORT-TERM TOXICITY STUDY OF ZINC  PHOSPHIDE IN
                ALBINO RATS.  INDIAN J EXPTL BIOL.  18: 854-857.

ZINEB                            012122-67-7
        010085  BLACKWELL-SMITH RJ JR,  JK FINNEGAN, PS LARSON, ET AL.  1953. TOXICOLOGIC STUDIES ON ZINC AND
                DISODIUMETHYLENEBISDITHIOCARBAMATES. J PHARMACOL EXP THER. 109: 159-166.

                US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ZINEB.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,  WASHINGTON, DC.
                                                                                                                                        R1-81

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                      REFERENCES FOR  HEAST  TABLE 2: ALTERNATE METHODS  -  SUBCHRONIC AND CHRONIC  TOXICITY
                                                         (OTHER THAN CARCIN06ENICITY)                                      January 1992

ACETONE  CYANOHYDRIN           000075-86-5
        010432  BLANK, TL AND DC THAKE. 1984. THREE-MONTH  INHALATION TOXICITY OF ACETONE  CYANOHYDRIN IN MALE AND FEMALE SPRAGUE-DAWLEY RATS.
                MONSANTO REPORT NOP.  MSL- 4423. TSCA 8(D)  SUBMISSION 878216397 (OTS0510325).

                US  EPA. 1988. HEALTH  AND ENVIRONMENTAL  EFFECTS DOCUMENT  FOR CYANOHYDRINS. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

ACETONITRILE            •        000075-05-8
        005208  COATE WB. 1983. 90-DAY SUBCHRONIC TOXICITY STUDY OF ACETONITRILE IN B6C3F1 MICE.   FINAL REPORT (REVISED).

ACETOPHENONE                    000098-86-2
        005211  IMASHEVA, NB. 1966. THRESHOLD CONCENTRATIONS OF ACETOPHENONE DURING SHORT- AND LONG-TERM INHALATION. IN:  NUTTONSON, M.Y.,
                AICE SURVEY OF USSR AIR POLLUTION LITERATURE, VIII, 1971, A COMPILATION OF TECHNICAL REPORTS OF THE BIOLOGICAL EFFECT AND  THE
                PUBLIC HEALTH ASPECTS OF ATMOSPHERIC POLLUTANTS, MY NUTTONSON, ED.  P.  79-93.

                US  EPA. 1987. HEALTH  AND ENVIRONMENTAL  EFFECTS DOCUMENT  FOR ACETOPHENONE. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

BARIUM                            007440-39-3
        005249  TARASENKO, M, 0 PROMIN AND A SILAYEV. 1977. BARIUM COMPOUNDS AS INDUSTRIAL POISONS (AN EXPERIMENTAL STUDY).  J. HYG. EPIDEM.
                MICROBIOL. IMMUNOL. 21:361.

                US  EPA. 1984. HEALTH  EFFECTS ASSESSMENT FOR BARIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.

CHLORO-1.3-BUTADIENE,  2-           000126-99-8
        005878  DU  PONT DE NEMOURS AND COMPANY, INC. 1985. 2-YEAR INHALATION'CARCINOGENICITY STUDY OF CHLOROPRENE IN RATS. El DU PONT DE
                NEMOURS AND CO., INC., WILMINGTON, DE.

                US  EPA. 1989.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2- CHLORO-1.3-BUTADIENE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF  SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

CHLOROBENZENE                   000108-90-7
        005353  DILLEY, JV. 1977. TOXIC EVALUATION OF INHALED CHLOROBENZENE. NIOSH, DHEW, CINCINNATI, OH CONTRACT 210-76-0126. CITED IN US
                EPA, 1985.

                US  EPA. 1989. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLOROBENZENE.  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF EMERGENCY AND  REMEDIAL RESPONSE,
                WASHINGTON, DC.
                                                                                                                                          R2-1

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                      REFERENCES FOR HEAST TABLE 2:  ALTERNATE HETHODS - SUBCHRONIC AND  CHRONIC TOXICITY
                                                         (OTHER THAN CARCIN06ENICITY)                                     January  1992


CYCLOPENTADIENE                000542-92-7
        005401  DOW. 1987. UNPUBLISHED DATA.  DOW CHEMICAL. USA,  MIDLAND, MI.

               US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCLOPENTADIENE.  PREPARED BY THE  OFFICE OF
               HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF SOLID
               WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

DICHLOROBENZENE,   1,2-        000095-50-1
        005412  HOLLINGSWORTH,  RL, VK ROWE, F OYEN, TR TORKELSON AND EM ADAMS.  1958. TOXICITY OF 0-DICHLOROBENZENE. AM MED ASSOC ARCH  IND
               HEALTH 17(1):180-187.

               US EPA. 1987.  HEALTH EFFECTS  ASSESSMENT FOR DICHLOROBENZENES. PREPARED BY THE OFFICE OF HEALTH  AND  ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
               DC.

DICHLORODIFLUOROMETHANE           000075-71-8
        005497  PRENDERGAST, JA, RA JONES, LJ JENKINS AND J SIEGAL. 1967. EFFECTS ON EXPERIMENTAL  ANIMALS OF LONG-TERM INHALATION OF
               TRICHLOROETHYLENE, CARBON TETRACHLORIDE, 1,1,1-TRICHLOROETHANE, DICHLORODIFLUOROMETHANE AND 1,1-DICHLOROETHYLENE. TOXICOL
               APPL PHARMACOL   10: 270-289.

               US EPA. 1987.  HEALTH EFFECTS  ASSESSMENT FOR FULLY HALOGENATED METHANES. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON,  DC.

DICHLOROETHANE,  1,1-         000075-34-3
        005789  HOFMANN, HT, H  BIRNSTIEL AND  P JOBST. 1971. ON THE INHALATION TOXICITY OF 1,1- AND 1,2-DICHLOROETHANE. ARCH TOXIKOL
               27:248-265.

               US EPA. 1984.  HEALTH EFFECTS  ASSESSMENT FOR 1,1-OICHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL
               ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON,  DC.

DICYCLOPENTADIENE             000077-73-6
        005424  DODD, DE, LC LONGO AND DL EISLER.  1982. DICYCLOPENTADIENE VAPOR NINETY-DAY INHALATION STUDY ON  RATS AND MICE. BUSHY RUN
               RESEARCH CENTER, EXPORT, PA,  TSCA 8E SUBMISSION  BY EXXON CHEM AMER DOC ID 88-8300464, ODD DOC ID  8EHQ-0283-0364, MICROFICHE
               NO. OTS204864.

               US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCLOPENTADIENE.  PREPARED BY THE  OFFICE OF
               HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI,  OH FOR THE OFFICE OF SOLID
               WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
                                                                                                                                         R2-2

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                      REFERENCES FOR  HEAST  TABLE  2: ALTERNATE METHODS -  SUBCHRONIC  AND CHRONIC  TOXICITY
                                                         (OTHER THAN CARCINOGENICITY)                                     January 1992


ETHOXYETHANOL  ACETATE,  2-   000111-15-9
        005952  UNION CARBIDE. 1984.  A TERATOGENIC EVALUATION OF CELLOSOLVE ACETATE IN FISHER 344 RATS AND  NEW ZEALAND WHITE RABBITS
                FOLLOWING INHALATION  EXPOSURE. BUSHY RUN RESEARCH CENTER, EXPORT, PA,  OCTOBER 1984. FYI-AX-1184-0360.

                US  EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR 2- ETHOXYETHANOL ESTERS. PREPARED BY THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE  OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

ETHYLENE  DIAMINE               000107-15-3
        005793  POZZANI UC AND CP CARPENTER, 1954. RESPONSE OF RATS TO REPEATED INHALATION OF ETHYLENE DIAMINE VAPORS. ARCH. IND. HYG. OCCUP.
                MED. 9: 223-226.

                US  EPA. 1988. HEALTH  AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR ETHYLENEDIAMINE. PREPARED BY  THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE  OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

FURFURAL                          000098-01-1
        005465  FERON, VJ, A KRUYSSE  AND HC DREEF VANDER MEULEN. 1979. REPEATED EXPOSURE TO  FURFURAL VAPOR:  13 WEEK STUDY  IN SYRIAN GOLDEN
                HAMSTERS. ZENTRASE.   BAKTEVIOL PAVASITEN KD  INFECTION SKV HYG AST 1 ORIG REIHE B 168(5-6):  442-451.

                US  EPA. 1988. HEALTH  AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR FURFURAL.  PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF  SOLID WASTE AND  EMERGENCY
                RESPONSE, WASHINGTON, DC.

METHACRYLONITRILE              000126-98-7
        005812  POZZANI, UC, CR KINKEAD AND JM KING. 1968. THE MAMMALIAN TOXICITY OF METHACRYLONITRILE. AM  IND HYG ASSOC J   29(3):202-210.

                US  EPA. 1987. HEALTH  AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR SELECTED NITRILES, PREPARED BY  THE OFFICE  OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE  OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

METHOXYETHANOL ACETATE,  2-           000110-49-6
        010001  MILLER RR, LL CALHOUN AND BL YANO. 1982. ETHYLENE GLYCOL MONOMETHYL ETHER: 13-WEEK VAPOR  INHALATION STUDY IN MALE RABBITS.
                REPORT PREPARED FOR THE CHEMICAL MANUFACTURERS ASSOCIATION, MARCH 25,  1982.

                US  EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR 2- METHOXYETHANOL ACETATE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE  OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.
                                                                                                                                          R2-3

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                      REFERENCES FOR HEAST TABLE 2:  ALTERNATE  METHODS -  SUBCHRONIC AND CHRONIC  TOXICITY
                                                        (OTHER THAN CARCINOGENICITY)                                      January 1992


METHYL ACRYLATE                000096-33-3
        010003  KLIMISH HJ AND U REIN INCHAUS.  1984. CARCINOGENICITY OF ACRYLATES: LONG-TERM  INHALATION STUDIES ON METHYL ACRYLATE (MA) AND
               N-BUTYL ACRYLATE (BA) IN RATS.  TOXICOLOGIST.  4(1): 53.

               US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR METHYL ACRYLATE.  PREPARED BY THE  OFFICE OF HEALTH  AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

METHYL ETHYL  KETONE          000078-93-3
        005558  LABELLE, CW AND H BRIEGER. 1955. VAPOUR TOXICITY OF A COMPOSITE SOLVENT AND  ITS PRINCIPAL COMPONENTS. ARCH IND HEALTH  12:
               623- 627.

               US EPA.  1989. UPDATED HEALTH  EFFECTS ASSESSMENT FOR METHYL ETHYL KETONE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND
               REMEDIAL RESPONSE, WASHINGTON,  DC

METHYL ISOBUTYL  KETONE       000108-10-1

        005562  UNION CARBIDE CORP. 1983. NINETY-DAY INHALATION  STUDY IN RATS  AND MICE SPONSORED BY CMA. US EPA/OTS PUBLIC FILES 0750507469.

               US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR METHYL ISOBUTYL KETONE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               RESPONSE, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
               WASHINGTON, DC.

METHYL STYRENE,  ALPHA-         000098-83-9
        010016  WOLF MA, VK ROWE, DO MCCOLLISTER,  ET AL. 1956. TOXICOLOGICAL STUDIES OF CERTAIN ALKYLATED BENZENES AND BENZENE. ARCH IND
               HEALTH. 14: 387-398.

               US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR ALPHA- METHYL STYRENE. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

METHYL STYRENE  (MIXED  ISOMERS)           025013-15-4
        005566  FINAL CHRONIC REPORT PERFORMED FOR THE NTP UNDER CONTRACT NO N01-ES- 38042.

               US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHYL STYRENES.  PREPARED BY THE  OFFICE OF HEALTH  AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

        005567  MRI (MIDWEST RESEARCH INSTITUTE).  1984. STUDY OF THE INHALATION CARCINOGENICITY (BIOASSAY) OF VINYL TOLUENE IN B6C3F1 MICE.
                                                                                                                                         R2-4

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                      REFERENCES  FOR  HEAST TABLE 2: ALTERNATE METHODS  - SUBCHRONIC  AND CHRONIC TOXICITY
                                                         (OTHER THAN CARCINOGENICITY)                                     January 1992


METHYLENE BROMIDE              000074-95-3
        010011   KEYES DG, JU HENCK,  GC JERSEY, RJ KOCIBA, OJ SCHUETZ AND  TO LANDRY. 1982. METHYLENE BROMIDE: A 90-DAY REPEATED INHALATION
                TOXICITY STUDY IN RATS AND DOGS WITH  A SUBSEQUENT TWO-YEAR HOLDING PERIOD FOR RATS. TOXICOLOGY RESEARCH LAB, HEALTH AND
                ENVIRONMENTAL SCIENCES, DOW CHEMICAL  CO., MIDLAND, MI.

                US EPA. 1987.  HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYLENE BROMIDE. PREPARED BY  THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR  THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

NITROBENZENE                    000098-95-3
        005589   CUT (CHEMICAL INDUSTRY INSTITUTE OF  TOXICOLOGY). 1984. NINETY- DAY INHALATION STUDY OF NITROBENZENE IN F-344 RATS, CD RATS
                AND B6C3F1 MICE WITH COVER LETTER DATED 6/24/84 AND EPA RESPONSE DATED 8/06/84, UNPUBLISHED STUDY. FYI-OTS-0784-0333 AND
                COMPUTER PRINT-OUT OF  PATHOLOGY FINDING.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR NITROBENZENE. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.

TRICHLOROBENZENE,  1,2,4-    000120-82-1
        010360   WATANABE,PG, RJ KOCIBA, RE HEFNER, ET AL. 1978. SUBCHRONIC TOXICITY STUDIES OF 1,2,4-TRICHLOROBENZENE IN EXPERIMENTAL
                ANIMALS. TOXICOL APPL  PHARMACOL  45(1):  322-333.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR 1,2,4-TRICHLOROBENZENE. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

TRICHLOROETHANE,   1,1,1-           000071-55-6
        005700   TORKELSON, RR, F OYEN,  DD MCCOLLISTER AND VK ROWE. 1958.  TOXICITY OF 1,1,1-TRICHLOROETHANE  AS DETERMINED ON LABORATORY
                ANIMALS AND HUMAN SUBJECTS. AM IND HYG ASSOC J  19: 353-362.

                US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 1,1,1-TRICHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.

TRICHLOROFLUOROMETHANE           000075-69-4
        005501   JENKINS, LJ, RA JONES,  RA COON AND J  SIEGAL. 1970. REPEATED AND CONTINUOUS EXPOSURES OF LABORATORY ANIMALS TO
                TRICHLOROFLUOROMETHANE. TOXICOL APPL  PHARMACOL  16: 133-142.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATEO METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF  EMERGENCY AND REMEDIAL RESPONSE,
                WASHINGTON, DC.
                                                                                                                                          R2-5

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                                              REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY
January 1992
ACEPHATE                                         030560-19-1
        010086  CHEVRON CHEMICAL  COMPANY. 1982. MRID NO 00105197

                US EPA. 198A.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR ACEPHATE. PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,  WASHINGTON DC.

ACROLEIN                                         000107-02-8
        005001  US EPA. 1987.  HEALTH EFFECTS ASSESSMENT FOR ACROLEIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
                WASHINGTON,  DC.

ACRYLAMIDE                                      000079-06-1
        010087  JOHNSON K,  S GORZINSKI, KM BODNER, ET AL.   1986.   CHRONIC TOXICITY AND ONCOGENICITY STUDY ON ACRYLAMIOE INCORPORATED  IN THE
                DRINKING WATER OF FISCHER 344 RATS. DOW CHEMICAL,  USA,  MIDLAND, MI.

                US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR ACRYLAMIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,  WASHINGTON, DC.

ACRYLONITRILE                                  000107-13-1
        005004  BIO/DYNAMICS,  INC.  1980. A 24-MONTH ORAL TOXIC!TY/CARCINOGENICITY STUDY OF ACRYLONITRILE ADMINISTERED IN DRINKING WATER TO
                FISCHER 344  RATS.  FINAL REPORT, VOL 1-4.  PREPARED BY BIO/DYNAMICS, INC.,  DIVISION OF BIOLOGY AND SAFETY EVALUATION, EAST
                MILLSTONE,  NJ, UNDER PROJECT NO 77-1744 (BDN-77-27)  FOR MONSANTO COMPANY,  ST LOUIS, MO.

                BIO/DYNAMICS,  INC.  1980. A 24- MONTH ORAL  TOXICITY/CARCINOGENICITY STUDY OF ACRYLONITRILE ADMINISTERED BY INTUBATION TO
                SPARTAN RATS,  FINAL REPORT, VOL 1 AND 2. PREPARED  BY BIO/DYNAMICS, INC.,  DIVISION OF BIOLOGY AND SAFETY EVALUATION,
                EAST MILLSTONE, NJ, UNDER PROJECT NO 77- 1745  FOR  MONSANTO COMPANY, ST LOUIS,  MO.

                QUAST,  JF,  CE  WADE, CG HUMISTON ET AL. 1980. A 2-YEAR TOXICITY AND ONCOGEN I CITY STUDY WITH ACRYLONITRILE INCORPORATED IN
                THE DRINKING WATER  OF RATS.  PREPARED BY THE TOXICOLOGY RESEARCH LABORATORY, HEALTH AND ENVIRONMENTAL RESEARCH,
                DOW CHEMICAL USA, MIDLAND, MI FOR THE CHEMICAL MANUFACTURERS ASSOCIATION,  WASHINGTON, DC.

                US EPA. 1983.  HEALTH ASSESSMENT DOCUMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, RESEARCH TRIANGLE PARK, NC.

                US EPA. 1987.  HEALTH EFFECTS ASSESSMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
                WASHINGTON,  DC.
                                                                                                                                             R3-1

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                                             REFERENCES FOR HEAST TABLE 3:    CARCINOGENICITY                          January 1992
ACRYLONITRILE                                 000107-13-1, continued
        005003  O'BERG,  M.  1980. EPIDEMIOLOGIC STUDY OF WORKERS EXPOSED TO ACRYLONITRILE. J OCCUP MED   22: 245-252.

                US  EPA.  1983. HEALTH ASSESSMENT DOCUMENT FOR ACRYLONITRILE.  PREPARED BY THE OFFICE OF  HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE,  RESEARCH TRIANGLE PARK, NC.

                US  EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR ACRYLONITRILE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFflCE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               'EMERGENCY RESPONSE, WASHINGTON, DC.

ALACHLOR                                        015972-60-8
        010180  US  EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ALACHLOR. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON DC.

                US  EPA.  1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP.

ALDRIN                                           000309-00-2
        005006  EPSTEIN, SS. 1975. THE CARCINOGENICITY OF DIELDRIN, PART I.  SCI TOTAL ENVIRON  4: 1-52.

                NCI  (NATIONAL CANCER INSTITUTE).  1978. BIOASSAYS OF ALDRIN AND  DIELDRIN FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS
                TECH REP SER NO 21. NCI-C6-TR-66 DHEW PUBLICATION NO. (NIH)  78-821.

                DAVIS, KJ,  OG FITZHUGH. 1962. TUMOR I GEN 1C POTENTIAL OF ALDRIN AND DIELDRIN FOR MICE. TOXICOL APPL PHARMACOL  4:  187-
                189.

                DAVIS, KJ.  1965. PATHOLOGY REPORT ON MICE FED ALDRIN, DIELDRIN, HEPTACHLOR, OR HEPTACHLOR EPOXIDE FOR TWO YEARS.  INT  FOOD
                DRUG ADMIN.

                US  EPA.  1986. CARCINOGENICITY ASSESSMENT OF ALDRIN AND DIELDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, CARCINOGEN ASSESSMENT GROUP, WASHINGTON, DC.

ALLYL CHLORIDE                                000107-05-1
        010181  US  EPA.  1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
                AND EMERGENCY RESPONSE, WASHINGTON, DC.

ANILINE                                          000062-53-3
        010088  CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY).  1982.  104-WEEK CHRONIC TOXICITY STUDY IN RATS: ANILINE HYDROCHLORIDE.
                FINAL REPORT.

                US  EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ANILINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.
                                                                                                                                             R3-2

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                                              REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                           January  1992



ARAMITE                                          000140-57-8
        010206  OSER. BL, M OSER. 1962.  2-(P-TERT-BUTYLPHENOXY)ISOPROPYL 2-CHLOROETHYL SULFITE (ARAMITE). II.CARCINOGENICITY. TOXICOL APPL
                PHARMACOL 4:70-88

                POPPER, H, SS STEINBERG,  BL OSER, H OSER. 1960. THE CARCINOGENIC  EFFECT OF ARAMITE IN RATS.  CANCER 13<5):1035-1046.

                US EPA. 1989. HEALTH AND  ENVIRONMENTAL EFFECTS DOCUMENT FOR ARAMITE.  PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

ARSENIC,  INORGANIC                           007440-38-2
        005007  BROWN, CC AND KC CHU. 1983. APPROACHES TO EPIDEMIOLOGIC ANALYSIS  OF PROSPECTIVE AND RETROSPECTIVE STUDIES:  EXAMPLE OF LUNG
                CANCER AND EXPOSURE TO ARSENIC.  IN: RISK ASSESSMENT:   PROC SIMS CONFERENCE ON ENVIRONMENTAL  EPIDEMIOLOGY, JUNE 28-JULY2,
                1982, ALTA UT.  SIAM PUBLICATION.

                BROWN, CC AND KC CHU. 1983. IMPLICATIONS OF THE MULTISTAGE THEORY OF  CARCINOGENESIS APPLIED  TO OCCUPATIONAL ARSENIC
                EXPOSURE. J NAT CANCER INST   70: 455- 463.

                LEE-FELDSTEIN, A. 1983. ARSENIC  AND RESPIRATORY CANCER IN MAN:  FOLLOW-UP OF AN OCCUPATIONAL  STUDY.  IN:  ARSENIC:
                INDUSTRIAL, BIOMEDICAL, AND ENVIRONMENTAL PERSPECTIVES, W LEDERER AND R FENSTERHEIM,  EDS,  VAN NOSTRAND REINHOLD, NEW YORK.

                BROWN, CC AND KC CHU. 1983. A NEW METHOD FOR THE ANALYSIS OF  COHORT STUDIES: IMPLICATIONS OF  THE MULTISTAGE THEORY OF
                CARCINOGENESIS APPLIED TO OCCUPATIONAL ARSENIC EXPOSURE. ENVIRON  HEALTH PERSP 50:293-308.

                HIGGINS, I. 1982. ARSENIC AND RESPIRATORY CANCER AMONG A SAMPLE OF ANACONDA SMELTER WORKERS.  REPORT  SUBMITTED TO THE
                OCCUPATIONAL SAFETY HEALTH ADMINISTRATION IN THE COMMENTS OF  THE  KENNECOTT MINERALS ON TH ElMORGAN 1C ARSENIC RULEMAKING,
                EXHIBIT 203-5.

                ENTERLINE, PE AND CM MARSH. 1982. MORTALITY AMONG WORKERS EXPOSED TO  ARSENIC AND OTHER SUBSTANCES IN A COPPER SMELTER. AM J
                EPIDEMIOL 116: 895-911.

                US EPA. 1984. HEALTH EFFECTS  ASSESSMENT FOR ARSENIC.  PREPARED BY  THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR  THE  OFFICE OF EMERGENCY AND  REMEDIAL RESPONSE,
                WASHINGTON, DC

                US EPA. 1980. HEALTH ASSESSMENT  DOCUMENT FOR INORGANIC ARSENIC. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RESEARCH TRIANGLE PARK, NC.
                                                                                                                                              R3-3

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                                             REFERENCES FOR  HEAST  TABLE  3:   CARCINOGENICITY                           January 1992



ASBESTOS                                        001332-21-4
        005919  US EPA.  1986. AIRBORNE ASBESTOS HEALTH ASSESSMENT UPDATE. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, RESEARCH TRIANGLE PARK, NC. EPA 600/8-84/003F.

        005010  NTP (NATIONAL TOXICOLOGY PROGRAM). 1985.  TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHRYSOTILE ASBESTOS (CAS  NO  1200-29-5) IN
                F344/N RATS  (FEED STUDIES). TECHNICAL  REPORT SERIES NO 295.

                US EPA.  1988. DRINKING WATER CRITERIA  DOCUMENT  FOR ASBESTOS. PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER, WASHINGTON,  DC.

ATRAZINE                                        001912-24-9
        010380  CIBA-GEIGY.  1986. TWO- YEAR FEEDING STUDY IN THE RAT. CONDUCTED BY AMERICAN BIOGENICS CORP. EPA MRID NO 262714-262727.

                US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR ATRAZINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY
                RESPONSE,  WASHINGTON DC.

AZOBENZENE                                      000103-33-3
        010089  NCI (NATIONAL CANCER INSTITUTE).  1979.  BIOASSAY OF AZOBENZENE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS TECHNICAL
                REPORT SERIES.  NO.  154. US DHEW PUBL NO.  (NIH)  79-1710. P 112.

                US EPA.  1985. HEALTH AND ENVIRONMENTAL EFFECTS  PROFILE FOR AZOBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH  FOR THE OFFICE OF SOLID WASTE AND  EMERGENCY
                RESPONSE,  WASHINGTON, DC.

BENZENE                                          000071-43-2
        005011  WONG. 0,  RW  MORGAN  AND MD WHORTON. 1983.  COMMENTS ON THE NIOSH STUDY OF LEUKEMIA IN BENZENE WORKERS. TECHNICAL REPORT
                SUBMITTED  TO GULF CANADA, LTD, BY ENVIRONMENTAL HEALTH ASSOCIATES, AUGUST 31. CITED IN US EPA, 1985.

                OTT, MG,  JC  TOWNSEND, WA FISHBECK AND  RA  LANGNER. 1978. MORTALITY AMONG WORKERS OCCUPATIONALLY EXPOSED TO BENZENE. ARCH
                ENVIRON HEALTH   33: 3-10.

                RINSKY,  RA,  RJ  YOUNG AND AB SMITH. 1981.  LEUKEMIA IN BENZENE WORKERS. AM  J IND MED  2: 217-245.

                US EPA.  1987. MEMORANDUM FROM J. ORME  HEB,  CSD/OOW  TO C. VOGT, JUNE, 1987. CRITERIA AND STANDARDS DIVISION, ODW.

                US EPA.  1985.  INTERIM QUANTITATIVE CANCER UNIT  RISK ESTIMATES DUE TO INHALATION OF BENZENE. OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSEMENT, CARCINOGEN  ASSESSMENT GROUP, WASHINGTON, DC. OFFICE OF AIR QUALITY PLANNING AND  STANDARDS,
                WASHINGTON,  DC.
                                                                                                                                              R3-4

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                                             REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                          January 1992



BENZIDINE                                      000092-87-5
        0050U  ZAVON, HR, U HOEGG AND E BINGHAM. 1973.  BENZIDINE EXPOSURE AS  A CAUSE OF BLADDER TUMORS. ARCH ENVIRON  HEALTH  27: 1-73.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

                US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR  BENZIDINE. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF WATER REGULATIONS AND
                STANDARDS, WASHINGTON, DC.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT  FOR  BENZIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI,  OH FOR  THE OFFICE OF EMERGENCY AND REMEDIAL  RESPONSE,
                WASHINGTON, DC.

BENZO[A]ANTHRACENE                          000056-55-3
        010182  REFER TO IRIS.

BENZO[A]PYRENE                                000050-32-8
        005016  NEAL J, RH RIGDON. 1967. GASTRIC TUMORS IN MICE FED BENZOCA]PYRENE. A QUANTITATIVE  STUDY. TEX REP BIOL MED 25:553.


                BRUNE  H, RP DEUTSCH-WENZEL, M  HABS, S IVANKOVIC AND D SCHMAHL.  1981.   INVESTIGATION OF  THE TUMOR I GEN 1C  RESPONSE  TO
                BENZO[A]PYRENE IN AQUEOUS  CAFFEINE APPLIED ORALLY TO SPRAGUE-DAWLEY  RATS.   J CANCER RES  CLIN ONCOL 102:  153-157.

                US EPA. 1991. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.

                US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR  POLYNUCLEAR AROMATIC HYDROCARBONS. PREPARED  BY THE OFFICE OF
                HEALTH AND ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE OF
                WATER REGULATIONS AND STANDARDS, WASHINGTON, DC.

        007777  THYSSEN, JJ ALTHOFF, G KIMMERLE AND U MOHR.  1981.  INHALATION STUDIES WITH BENZOCA1PYRENE IN SYRIAN  GOLDEN HAMSTERS.
                J NATL  CANCER INST 66(3);  575-577.

                US EPA.   1984.  HEALTH  EFFECTS ASSESSMENT FOR  BENZO(A)PYRENE.   PREPARED  BY  THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR  THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,  WASHINGTON,  DC.

BENZO[B]FLUORANTHENE                        000205-99-2
        010183  REFER TO IRIS.

BENZO[K]FLUORANTHENE                        000207-08-9
        010090  REFER TO IRIS.
                                                                                                                                           R3-5

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                                             REFERENCES  FOR  HEAST  TABLE  3:   CARCINOGENICITY                          January 1992



BENZOTRICHLORIDE                              000098-07-7
        010092   FUKUOA K, H METSUSHITA AND  K  TAKEMOTO.  1978.   CARCINOGENICITY OF BENZOTRICHLORIDE BY THE ORAL ROUTE OF ADMINISTRATION
                (J-4774). IN: PROC 52ND ANN MEET JAPANESE INDUSTRIAL HEALTH ASSOC.  TSCA 8E SUBMISSION DOCUMENT NO 88-8000360, FICHE  #
                204867. P 516-517.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZOTRICHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

BENZYL CHLORIDE                               000100-44-7
        010093   LIJINSKY W.  1986.  CHRONIC BIOASSAY OF BENZYL CHLORIDE IN F344 RATS AND  (C57BL/6J X BALB/OF1 MICE. J NATL CANCER  INST.
                76:  1231- 1236.

                US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BENZYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

BERYLLIUM                                       007440-41-7
        005018   SCHROEDER, HA AND M MITCHNER.  1975. LIFE-TERM  STUDIES IN RATS: EFFECTS OF ALUMINUM, BARIUM, BERYLLIUM AND TUNGSTEN.  J.
                NUTR. 105: 421-427.

        005017   WAGONER, JK, PF INFANTE AND OL BAYLISS. 1980.  BERYLLIUM:  AN ETIOLOGIC AGENT IN THE INDUCTION OF LUNG CANCER, NONNEOPLASTIC
                RESPIRATORY DISEASE, AND HEART DISEASE AMONG INDUSTRIALLY EXPOSED WORKERS. ENVIRON RES  21: 15-34.

                US EPA. 1987. HEALTH ASSESSMENT DOCUMENT FOR BERYLLIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  RESEARCH TRIANGLE PARK,  NC.

BIS(CHLOROMETHYL)  ETHER                    000542-88-1
        005077   KUSCHNER, M, S LASKIN, RT DREW, ET AL. 1975. INHALATION CARCINOGENICITY OF ALPHA HALO ETHERS:  III.  LIFETIME AND LIMITED
                PERIOD INHALATION STUDIES WITH BIS(CHLOROMETHYL) ETHER AT 0.1 PPM.  ARCH ENVIRON HEALTH 30(2): 73-77.

BIS(2-CHLOROETHYL)  ETHER                   000111-44-4
        005076   INNES, JRM, BM ULLAND, MG VALERIO ET AL. 1969. BIOASSAY OF PESTICIDES AND INDUSTRIAL CHEMICALS FOR TUMOR!GEN I CITY IN MICE:
                A PRELIMINARY NOTE. J NATL  CANCER INST  42: 101-1114.

                US EPA. 1987. HEALTH EFFECTS  ASSESSMENT FOR BIS(2-CHLOROETHYL)ETHER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL
                RESPONSE, WASHINGTON, DC.

                US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLOROALKYL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER REGULATIONS
                AND  STANDARDS, WASHINGTON,  DC.
                                                                                                                                            R3-6

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                                             REFERENCES  FOR HEAST  TABLE  3:   CARCINOGENICITY                          January 1992



BIS(2-CHLOROISOPROPYL)  ETHER              039638-32-9
        005080  NTP  (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENIC BIOASSAY OF BIS(2-CHLORO-1-METHYLETHYL)  ETHER (70%) CONTAINING
                2-CHLORO-1- ETHYLETHYL-(2-CHLOROPROPYL) ETHER (30%)  IN B6C3F1 MICE (GAVAGE STUDY). NCI CARCINOGEN TECH REP SER NO 239.
                105  P. ALSO PUBL AS DHHS (NIH) 83-1795

                US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR HALOETHERS.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

BIS(2-ETHYLHEXYL)PHTHALATE                000117-81-7
        005120  NTP  (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENESIS  BIOASSAY OF  DK2-ETHYLHEXYL) PHTHALATE (CAS NO 117-81-7)  IN F344
                RATS AND B6C3F1 MICE (FEED STUDY). NTP TECH REPORT SER NO 217, NIH/PUB-  82-1773. NTP-80-37,  NITS PB82-184011.

                US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC  ACID ALKYL, ARYL AND ALKYL/ARYL ESTERS. PREPARED  BY THE
                OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE
                OF SOLID WASTE AND EMERGENCY  RESPONSE, WASHINGTON, DC.

                US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID  ESTERS. PREPARED BY THE  OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

BROMODICHLOROMETHANE                         000075-27-4
        005148  NTP  (NATIONAL TOXICOLOGY PROGRAM). 1987. NTP TECHNICAL REPORT ON THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF
                BROMODICHLOROMETHANE (CAS NO  75-27-4) IN F344 RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP, RESEARCH TRIANGLE PARK, NC.
                NTP  TR 321. US DEPT OF HEALTH AND HUMAN SERVICES, PUBLIC HEALTH SERVICE, NATIONAL  INSTITUTE  OF HEALTH.

                US EPA.  1987. HEALTH EFFECTS  ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC. ECAO-CIN-H083.

BROMOETHENE                                    000590-60-2
        010094  BENYA TJ, WM BASEY, MA DORATO AND PE BERTEAU.  1982.   INHALATION CARCINOGENICITY BIOASSAY OF VINYL BROMIDE IN RATS. TOXICOL
                APPL PHARMACOL. 64: 367-379.

                US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR BROMOETHENE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.
                                                                                                                                            R3-7

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                                             REFERENCES  FOR HEAST TABLE 3:   CARCINOGENICITY                           January 1992



BROMOFORM                                       000075-25-2
        005150  NTP  (NATIONAL TOXICOLOGY PROGRAM).  1988. TECHNICAL REPORT  ON  THE TOXICOLOGY AND CARCINOGENESIS STUDIES OF TRINALOMETHANE
                (BROMOFORM) (CAS NO 75-25-2)  IN  F344 RATS AND B6C3F1  MICE  (GAVAGE STUDIES). NTP-TR  350.

                US EPA.  1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BROMOFORM. PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

BUTADIENE                                       000106-99-0
        009991  NTP  (NATIONAL TOXICOLOGY PROGRAM).  1984. TOXICOLOGY AND CARCINOGENESIS STUDIES OF 1,3-BUTADIENE (CAS. 106-99-00)  IN
                B6C3F1 MICE (INHALATION STUDIES).

                US EPA.  1985. MUTAGENICITY AND CARCINOGENICITY ASSESSMENT  OF  1,3-BUTADIENE. OFFICE  OF HEALTH AND ENVIRONMENTAL  ASSESSMENT,
                WASHINGTON, DC. EPA 600/8-85-004F.  NTIS-PB86-125507.

                US EPA.  1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1,3-BUTADIENE.  PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID  WASTED AND
                EMERGENCY RESPONSE, WASHINGTON,  DC.

BUTYL  BENZYL PHTHALATE,  N-                 000085-68-7
        005122  US EPA.  1987. HEALTH EFFECTS  ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS.  PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID  WASTE
                AND  EMERGENCY RESPONSE, WASHINGTON, DC.

CADMIUM                                          007440-43-9
        005020  US EPA.  1984. HEALTH EFFECTS  ASSESSMENT FOR CADMIUM.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
                WASHINGTON, DC.

                US EPA.  1988. UPDATED HEALTH  EFFECTS ASSESSMENT FOR CADMIUM.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
                WASHINGTON, DC.

        005019  THUN, MJ, TM SCHNORR, AB SMITH AND  WE HALPERIN. 1985. MORTALITY AMONG A COHORT OF US CADMIUM PRODUCTION WORKERS:  AN
                UPDATE.  J NATL CANCER INST  74(2):  325-333.

                US EPA.  1985. UPDATED MUTAGENICITY  AND CARCINOGENICITY ASSESSMENT OF CADMIUM: ADDENDUM TO THE HEALTH ASSESSMENT DOCUMENT
                FOR  CADMIUM. (MAY 1981, EPA 600/8-81-023) EPA 600/8-83-025F.

CAPTAFOL ,                                       002425-06-1
        010095  US EPA.  1984.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAFOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA  AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.



                                                                                                                                             R3-8

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                                              REFERENCES  FOR  HEAST  TABLE  3:   CARCINOGENICITY                           January 1992



CAPTAN                                           000133-06-2
        010184  NCI (NATIONAL CANCER  INSTITUTE). 1977. BIOASSAY OF  CAPTAN FOR POSSIBLE CARCINOGENICITY. CAS NO.  133-06-2. NTIS PB-273475.
                CHEVRON. 1982.  UNPUBLISHED STUDY.

                BIOOYNAMICS.  1983.  SUBMITTED CHEVRON CHEMICAL CORPORATION. UNPUBLISHED STUDY.

                US EPA. 1984. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAN. PREPARED  BY  THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,  WASHINGTON, DC.

                US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK  GROUP.

CARBAZOLE                                       000086-74-8
        010096  TSUDA H, A HAZIWARA,  M SHIBATA, M OHSIMA AND N ITO.  1982. CARCINOGENIC EFFECT  OF CARBAZOLE IN THE  LIVER OF  (C57BL/6N X
                C3G/HEN)F1.MICE.  J  NATL CANCER INST. 69: 1383-1389.

                US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBAZOLE. PREPARED BY THE OFFICE OF HEALTH  AND  ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,  WASHINGTON, DC.

CARBON  TETRACHLORIDE                        000056-23-5
        005022  DELLA PORTA,  GB,  B  TERRACINI AND KP SHUBIK.  1961. INDUCTION WITH CARBON TETRACHLORIDE OF LIVER CELL CARCINOMAS IN HAMSTERS.
                J NATL CANCER INST  26: 855-863.

                EDWARDS, J,  WE  HESTON AND HA OALTON. 1942.  INDUCTION OF THE CARBON TETRACHLORIDE HEPATOMA IN STRAIN L MICE.  J NATL CANCER
                INST  3: 297-301.

                NCI (NATIONAL CANCER  INSTITUTE). 1976. REPORT ON CARCINOGENESIS BIOASSAY OF  CHLOROFORM. NTIS PB264-018.  NCI-CG-TR-3.

                US EPA. 1984. HEALTH  ASSESSMENT DOCUMENT FOR CARBON TETRACHLORIDE. PREPARED  BY  THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH.

                US EPA. 1984. HEALTH  EFFECTS ASSESSMENT FOR  CARBON  TETRACHLORIDE. PREPARED BY THE OFFICE OF HEALTH  AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL
                RESPONSE,  WASHINGTON, DC.

CHLORANIL                                       000118-75-2
        010097  BRL (BIONETICS  RESEARCH LABS, INC.).  1968.   EVALUATION OF CARCINOGENIC, TERATOGENIC AND MUTAGENIC  ACTIVITIES OF SELECTED
                PESTICIDES AND  INDUSTRIAL CHEMICALS. VOLUME  I: CARCINOGENIC STUDY. NTIS PB 223159.

                US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORANIL. PREPARED BY THE OFFICE OF HEALTH  AND  ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,  WASHINGTON, DC.



                                                                                                                                             R3-9

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                                             REFERENCES FOR  HEAST TABLE  3:   CARCINOGENICITY                           January 1992



CHLORDANE                                      000057-74-9
        005024  VELSICOL. 1973. EIGHTEEN MONTH ORAL CARCINOGENIC STUDY IN MICE,  DECEMBER  14, 1973. MRID  NO. 00067568.

                NCI  (NATIONAL CANCER  INSTITUTE). 1977. BIOASSAY OF  CHLORDANE  FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS  TECH REP SER
                NO 8. ALSO PUBL AS DHEW PUBL NO (NIH)  77-808.


                US EPA. 1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLORDANE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH  FOR THE OFFICE  OF EMERGENCY AND REMEDIAL
                RESPONSE, WASHINGTON, DC.

                US EPA. 1986. CARCINOGENICITY ASSESSMENT OF CHLORDANE AND HEPTACHLOR/HEPTACHLOR EPOXIDE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, CARCINOGEN ASSESSMENT GROUP, WASHINGTON, DC.

CHLORO-2-METHYLANILINE  HYDROCHLORIDE, 4-                    003165-93-3
        010419  WEISBURGER EK, AB RUSSFIELD, F HOMBURGER, ET AL.  1978.  TESTING OF  TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES
                FOR  LONG-TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.

                US EPA. 1986. HEALTH  AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-CHLORO-2-METHYLANILINE AND  4-CHLORO-2-METHYLANIL1NE
                HYDROCHLORIDE. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,
                CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.

CHLORO-2-METHYLANILINE,  4-                000095-69-2
        010098  WEISBURGER EK, AB RUSSFIELD, F HOMBURGER, ET AL. 1978.  TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES
                FOR  LONG- TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL  TOXICOL.  2:  325- 356.

                US EPA. 1986.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4-  CHLORO-2-METHYLANILINE AND 4-CHLORO-2-METHYLANILINE
                HYDROCHLORIDE. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,
                CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
                                                                                                                                          R3-10

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                                             REFERENCES FOR  HEAST TABLE 3:   CARCINOGENICITY                          January 1992



CHLOROFORM                                         000067-66-3
        005036  JORGENSON,  TA, EF MEIERHENRY, CJ RUSHBROOK ET AL. 1985. CARCINOGENICITY OF CHLOROFORM IN DRINKING WATER TO HALE OSBORNE-
                MENDEL  RATS AND  FEMALE B6C3F1 MICE.  FUND APPL TOXICOL (USA) 5(4):  760-769.

                US EPA.  1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLOROFORM.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL
                RESPONSE, WASHINGTON, DC.

        005035  NCI  (NATIONAL CANCER INSTITUTE). 1976.  REPORT ON CARCINOGENESIS  BIOASSAY OF CHLOROFORM. NTIS  PB264-018.

                US EPA.  1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR CHLOROFORM.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL
                RESPONSE, WASHINGTON, DC.

                US EPA.  1985. HEALTH ASSSESSMENT DOCUMENT FOR CHLOROFORM. PREPARED BY  THE OFFICE OF HEALTH AND  ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CIN, RES TRIANGLE  PARK,  NC.

CHLOROMETHANE                                  000074-87-3
        005038  CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXICOLOGY). 1981. FINAL REPORT ON 24-MONTH INHALATION STUDY ON METHYL CHLORIDE.
                PREPARED BY BATTELLE-COLUMBUS LABORATORIES,  COLUMBUS, OH  DECEMBER 31.

                NIOSH (NATIONAL  INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH). 1984. CARCINOGENIC RISK ASSESSMENT FOR OCCUPATIONAL EXPOSURE
                TO MONOHALOMETHANES. NTIS PB85-111623.

                US EPA.  1986. HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR METHYL  CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON,  DC.

                US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR  CHLOROMETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND  REMEDIAL RESPONSE, WASHINGTON,
                DC.

CHLOROMETHYL  METHYL  ETHER                  000107-30-2
        005081  US EPA.  1987. HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR HALOETHERS. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

CHLORONITROBENZENE,  0-                      000088-73-3
        010099  WEISBURGER  EK, AB RUSSFIELD, F HOMBURGER, ET AL.  1978.  TESTING OF TWENTY-ONE ENVIRONMENTAL  AROMATIC AMINES OR DERIVATIVES
                FOR LONG-TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.

                US EPA.  1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORONITROBENZENES. PREPARED BY  THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT  OFFICE, CINCINNATI, OH FOR THE  OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON,  DC.


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                                            REFERENCES  FOR HEAST TABLE  3:   CARCINOGENICITY                          January 1992



CHLORONITROBENZENE,  P-                     000121-73-3
        010100  WEISBURGER EK,  AB  RUSSFIELD, f HOMBURGER, ET AL.  1978.   TESTING OF  TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES
               FOR LONG-TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2:  325-356.

               US EPA. 1985.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR CHLORONITROBENZENES. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.

CHLORTHALONIL                                 001897-45-6
        010384  1RDC. 1985. TUMORIGENICITY STUDY IN  RATS. CHLOROTHALONIL.  099-5TX-80-234-008.

               US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR CHLORTHALONIL. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENCY RESPONSE, WASHINGTON,  DC.
CHROMIUM(VI)                                   018540-29-9
        005091  MANCUSO, TF. 1975.  INTERNATIONAL CONFERENCE ON HEAVY METALS IN THE ENVIRONMENT, TORONTO,  CANADA, OCT 27-31. CITED IN US
               EPA, 1984.

               US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR HEXAVALENT  CHROMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL
               RESPONSE, WASHINGTON, DC.

               US EPA. 1984. HEALTH ASSESSMENT  DOCUMENT FOR CHROMIUM.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI,  OH FOR THE US  ENVIRONMENTAL PROTECTION AGENCY, RESEARCH TRIANGLE
               PARK, NC.

CHRYSENE                                        000218-01-9
        010185  REFER TO IRIS.

COKE  OVEN EMISSIONS                         008007-45-2
        005039  MAZUMDAR, S, C  REDMOND, W SOLLECITO  AND N SUSSMAN. 1975.  AN EPIDEMIOLOGICAL STUDY OF EXPOSURE  TO COAL-TAR-PITCH VOLATILES
               AMONG COKE OVEN WORKERS. APCA J   25(4):  382-389.

               LAND.CE. 1976.  PRESENTATION AT OCCUPATIONAL SAFETY AND  HEALTH ADMINISTRATION HEARINGS ON COKE  OVEN STANDARDS.

               US EPA. 1984. CARCINOGEN ASSESSMENT  OF COKE OVEN EMISSIONS. PREPARED BY  THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
               CARCINOGEN ASSESSMENT GROUP, WASHINGTON, DC.

CREOSOTE, COAL  TAR                          008001-58-9
        005042  REFER TO IRIS.
                                                                                                                                         R3-12

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                                             REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                           January  1992



CRESOL,  M-                                      000108-39-4
        010187  US EPA.  1985.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR CRESOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
                WASHINGTON,  DC.

                US EPA.  1990.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP.

CRESOL,  0-                                      000095-48-7
        010186  US EPA.  1985.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR CRESOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,  WASHINGTON, DC.

                US EPA.  1990.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP.
CRESOL,  P-                                      000106-44-5
        010188  US EPA.  1985.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR CRESOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE,  WASHINGTON, DC.

                US EPA.  1990.  CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP.

CROTONALDEHYDE                                000123-73-9
        010190  CHUNG,  FL, T TAMAKA, SS HECHT. 1986.  INDUCTION OF LIVER TUMORS  IN  F344 RATS BY CROTONALDEHYDE. CAN RES 46:1285-1289.

                US EPA.  1989.  HEALTH AND ENVIRONMENTAL  EFFECTS DOCUMENT FOR CROTONALDEHYDE. PREPARED BY THE OFFICE OF HEALTH  AND
                ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY  RESPONSE, WASHINGTON,  DC.

ODD                                               000072-54-8
        010291 .-TOMATIS, L,  V  TURUSOV, RT CHARLES AND M BOICCHI.  1974.  EFFECT OF LONG-TERM EXPOSURE TO
                1,1-DICHLORO-2,2-BIS(P-CHLOROPHENYL)ETHYLENE, TO 1,1-DICHLORO-2,2-BIS(P-CHLOROPHENYL)ETHANE, AND TO THE TWO CHEMICALS
                COMBINED ON  CF-1 MICE.  J NATL CANCER INST.  52(3): 883- 891.

DDE                                               000072-55-9
        010292  TOMATIS, L,  V  TURUSOV, RT CHARLES AND M BOICCHI.  1974.  EFFECT OF LONG-TERM EXPOSURE TO
                1,1-DICHLORO-2,2-BlS(P-CHLOROPHENYL)ETHYLENE, TO 1,1-DICHLORO-2,2-BIS(P-CHLOROPHENYL)ETHANE, AND TO THE TWO CHEMICALS
                COMBINED ON  CF-1 MICE.  J NATL CANCER INST.  52(3): 883- 891

                NCI (NATIONAL  CANCER INSTITUTE). 1978.  BIOASSAY OF DDT, TDE AND P,P'-DDE FOR POSSIBLE CARCINOGENICITY. NCI REPORT NO 131.
                DHEW PUBL  NO (NIK) 78-1386.

                ROSSI  L, 0 BARBIERI, M SANGUINETI, JRP  CABRAL, P BRUZZI AND L SANTI.  1983. CARCINOGENICITY STUDY WITH TECHNICAL-GRADE DDT
                AND DDE  IN HAMSTERS. CANCER RES. 43:  776-781.



                                                                                                                                           R3-13

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DDT                                               000050-29-3
        005044  US  EPA.  1986. THE CARCINOGEN ASSESMENT GROUP'S EVALUATION OF THE CARCINOGENICITY OF DICOFOL (KELTHANE), DDT, DDE, AND ODD
                (TDE). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,  CARCINOGEN ASSESSMENT GROUP, WASHINGTON, DC, FOR THE
                HAZARD EVALUATION DIVISION, OFFICE OF PESTICIDE PROGRAMS, OFFICE OF PESTICIDES AND TOXIC SUBSTANCES, WASHINGTON, DC.

                US  EPA.  1988. UPDATED HEALTH EFFECTS ASSESSMENT FOR DDT. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.  EPA  540/1-86-026.

DECABROMODIPHENYL  OXIDE                    001163-19-5
        010102  US  EPA.  1987.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DECABROMODIPHENYL OXIDE. PREPARED BY  THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

                US  EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE  AND
                EMERGENCY RESPONSE, WASHINGTON, DC.

DIALLATE                                        002303-16-4
        010103  BRL (BIONETICS RESEARCH LABS, INC.).  1968.  EVALUATION OF CARCINOGENIC, TERATOGENIC, AND MUTAGENIC ACTIVITIES OF SELECTED
                PESTICIDES AND INDUSTRIAL CHEMICALS, VOL 1, CARCINOGENIC STUDY. PREPARED FOR NATIONAL CANCER INSTITUTE, US DEPARTMENT OF
              '  COMMERCE, WASHINGTON, DC. NTIS PB-223159.
                INNES,  JRM, BM ULLAND,  MG VALERIO, ET AL.  1969.  BIOASSAY OF PESTICIDES AND
                MICE: A PRELIMINARY NOTE. J  NATL CANCER  INST. 42: 1101-1114.
                                       INDUSTRIAL CHEMICALS  FOR TUMOR I GEN 1C ITY IN
                US EPA.  1983.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE  FOR DIALLATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR  THE OFFICE OF SOLID WASTE, WASHINGTON, DC.
DIBENZO[A,H]ANTHRACENE
        010191  REFER  TO  IRIS.
000053-70-3
                                                                                                                                           R3-14

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                                             REFERENCES FOR HEAST TABLE 3:   CARCINOGENICITY                          January 1992



DIBROMO-3-CHLOROPROPANE,  1,2-            000096-12-8
        010294  HAZELTON  LABORATIES, INC. 1977.  104 WEEK DIETARY STUDY IN RATS,  1.2-DIBROMO-3-CHLOROPROPANE  (DBCP). FINAL REPORT. UNPUBLISHED
                REPORT SUBMITTED TO DOW CHEMICAL CO.,  MIDLAND, MI. OCTOBER 29,1977.

                US EPA.  1988. DRINKING WATER CRITERIA  DOCUMENT FOR DIBROMOCHLOROPROPANE. PREPARED BY THE OFFICE OF HEALTH AND  ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER, WASHINGTON, DC.
                ECAO-CIN-410.

                US EPA.  1988. ASSESSMENT OF THE  CARCINOGENIC POTENTIAL OF 1,2-DIBROMO-3-CHLOROPROPANE (DBCP).  PREPARED BY THE  CARCINOGEN
                ASSESSMENT GROUP. AVAILABLE THROUGH RCRA/SUPERFUND DOCKET.

        009994  NTP (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENES1S BIOASSAY OF 1,2-DIBROMO-3-CHLOROPROPANE (CAS NO. 96-12-8) IN  F344 RATS
                AND B6C3F1 MICE (INHALATION STUDY). NTP-TR-NO 81-21.

                US EPA.  1989. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR  (CRAVE) WORK GROUP.

DIBROMOCHLOROMETHANE                           000124-48-1
        005152  NTP (NATIONAL TOXICOLOGY PROGRAM). 1985. TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLOROOIBROMOMETHANE (CAS NO 124-48-1) IN
                F/344/N  RATS AND B6C3F1 MICE. NTP TECH REP SER NO 282, DHHS NO  NIH 85-2538.

                US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE  OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL
                RESPONSE, WASHINGTON, DC.

DIBROMOETHANE, 1,2-                          000106-93-4
        005818  NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF 1,2-DIBROMOETHANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS
                REPORT SERIES NO 86. PB-288- 428.

                US EPA.  1987. HEALTH EFFECTS ASSESSMENT FOR ETHYLENE  DI BROMIDE.  PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL
                RESPONSE, WASHINGTON, DC.

                US EPA.  1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1,2-DIBROMOETHANE. PREPARED BY THE  OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND  ASSESSMENT  OFFICE, CINCINNATI,  OH FOR THE OFFICE OF SOLID WASTE,
                WASHINGTON,  DC.

        005071  NTP (NATIONAL TOXICOLOGY PROGRAM). 1982. CARCINOGENESIS BIOASSAY OF 1,2-DIBROMOETHANE (ETHYLENE OIBROMIDE)  (CAS NO
                106-93-4)  IN F3444 RATS AND B6C3F1 MICE (INHALATION STUDY). NTP  TECH REP SER NO 210, NIH PUBL  NO 82-1766.
                                                                                                                                            R3-15

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                                            REFERENCES FOR HEAST TABLE  3:   CARCINOGENICITY                          January 1992



DICHLORO-2-BUTENE,  1,4-                   000764-41-0
        005053  El DUPONT  DE NEMOURS AND CO. 1986. LONG-TERM INHALATION  STUDY WITH 1.4-DICHLOROBUTENE-2 (DCB) IN RATS. FINAL REPORT OTS
               8(E) FICHE 0509754.

               US EPA.  1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT  FOR DICHLOROBUTENES. PREPARED BY THE OFFICE OF HEALTH AND
               ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND  ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
               EMERGENY RESPONSE, WASHINGTON, DC.

DICHLOROBENZENE,  1,4-                      000106-46-7
        005050  NTP (NATIONAL TOXICOLOGY PROGRAM). 1986.  TOXICOLOGY AND  CARCINOGENESIS STUDIES OF 1,4-DICHLOROBENZENE IN F344/M RATS AND
               B6C3F1  MICE -- GALLEY DRAFT. US DHHS,  PHS, NIK TECH REP  SER NO 319.
               CONTAMINANTS. 1987. FR (JULY 8). 52:25690-25717.

DICHLOROBENZIDINE.3,3'-                   000091-94-1
        005815  STULA.  EF, H SHERMAN, JA ZAPP, ET AL.  1975. EXPERIMENTAL NEOPLASIA IN RATS FROM ORAL ADMINISTRATION OF
               3,3'-DICHLOROBENZIDINE,  4,4'-METHYLENE-BIS(2- CHLOROANILINE) AND 4,4'-METHYLENE-BIS (2-METHYLANILINE). TOXICOL APPL
               PHARMACOL  31:159-175.

DICHLOROETHANE,  1,1-                        000075-34-3
        005055  US EPA.  1984. HEALTH EFFECTS ASSESSMENT FOR  1,1-DICHLOROETHANE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE,  CINCINNATI, OH  FOR THE OFFICE OF EMERGENCY AND REMEDIAL
               RESPONSE,  WASHINGTON, DC.

DICHLOROETHANE,  1,2-                        000107-06-2
        005058  NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF 1,2-  DICHLOROETHANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS
               TECH REP SER NO 55, DHEW PUBL  NO (NIH) 78-1361.

               US EPA.  1985. HEALTH ASSESSMENT DOCUMENT FOR 1,2-DICHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
               ASSESSMENT, WASHINGTON,  DC. EPA 600/8-84-006F.
                                                                                                                                       R3-16

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                                              REFERENCES  FOR  HEAST  TABLE 3:   CARCINOGENICITY                           January 1992



DICHLOROETHYLENE,  1,1-                      000075-35-4
        005060  NTP (NATIONAL  TOXICOLOGY PROGRAM). 1982.  TECHNICAL  REPORT ON THE CARCINOGENESIS BIOASSAY OF VINYLIDENE CHLORIDE
                (CAS NO 75-35-4)  IN  F344 RATS AND B6C3F1  MICE (GAVAGE STUDY). NTP TECH REP  SER NO 228, DHHS NO NIH 82-1784.

                US EPA. 1985.  HEALTH ASSESSMENT DOCUMENT  FOR VINYLIDENE CHLORIDE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RES. TRIANGLE PARK, NC.

                US EPA. 1988.  UPDATED HEALTH EFFECTS ASSESSMENT  FOR 1,1- DICHLOROETHYLENE.  PREPARED BY THE OFFICE OF HEALTH  AND
                ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND
                REMEDIAL RESPONSE, WASHINGTON, DC.

        005059  MALTONI, C,  G  LEFEMINE, P CHIECO ET AL. 1985. EXPERIMENTAL RESEARCH ON VINYLIDENE CHLORIDE CARCINOGENESIS.  IN: ARCHIVES OF
                RESEARCH ON  INDUSTRIAL CARCINOGENESIS, VOL 3, C. MALTONI AND M. MEHLMAN, ED, PRINCETON SCIENTIFIC PUBLISHERS, PRINCETON, NJ.

                US EPA. 1985.  HEALTH ASSESSMENT DOCUMENT  FOR VINYLIDENE CHLORIDE. PREPARED  BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RES. TRIANGLE PARK. NC.

DICHLOROPROPANE,   1,2-                        000078-87-5
        005062  NTP (NATIONAL  TOXICOLOGY PROGRAM). 1986.  NTP TECHNICAL REPORT ON THE CARCINOGENESIS STUDIES OF 1,2-DICHLOROPROPANE
                (PROPYLENE DICHLORIDE).  (CAS NO. 78-87-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP-82-092,  NIH  PUBL NO
                84-2519, NTP TR 263. US DHHS, PHS, NIH.  AUGUST, 1986 DRAFT.

                US EPA. 1987.  HEALTH EFFECTS ASSESSMENT FOR 1,2-DICHLOROPROPANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
                ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
                RESPONSE, WASHINGTON, DC.

DICHLOROPROPENE,   1,3-                        000542-75-6
        010105  NTP (NATIONAL  TOXICOLOGY PROGRAM). 1985.   TOXICOLOGY AND CARCINOGENESIS STUDIES OF TELONE II IN F344/N RATS  AND B6C3F1
                MICE.  (GAVAGE  STUDIES) US DEPT HEALTH AND HUMAN  SERVICES, TECHNICAL REPORT  SER NO. 269. NIH PUBL. NO. 85-2525.

                US EPA. 1989.  HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR 1,3-DICHLOROPROPENE. PREPARED BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.

        010104  LOMAX  LG, WT STOTT,  KA JOHNSON, LL CALHOUN,  BL YANO AND JF QUASI. 1989.  THE CHRONIC TOXICITY AND ONCOGENICITY OF INHALED
                TECHNICAL GRADE 1,3-DICHLOROPROPENE IN RATS AND  MICE. FUND APPL TOXICOL. 12: 418-431.

                US EPA. 1989.  HEALTH AND ENVIRONMENTAL EFFECTS  DOCUMENT FOR 1,3-DICHLOROPROPENE. PREPARED BY THE OFFICE OF  HEALTH AND
                ENVIRONMENTAL  ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE,  WASHINGTON, DC.
                                                                                                                                            R3-17

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DIELDRIN                                         000060-57-1
        005816  NCI   (NATIONAL CANCER INSTITUTE).  1978.  BIOASSAYS OF ALDRIN AND DIELDRIN  FOR POSSIBLE CARCINOGENICITY. NATIONAL CANCER
                INSTITUTE CARCINOGEN TECH REP SER  NO 22   NCI-CG-TR-22. ALSO PUBL AS  DHEU  PUBL NO (NIH) 78-882.

                WALKER, AIT, E THORPEAND DE STEVENSON. 1972. THE TOXICOLOGY.OF DIELDRIN (HEOO): I. LONG-TERM ORAL  TOXICITY STUDIES IN MICE.
                FOOD  COSMET TOXICOL  11:415-432.

                MEIERHENREY, EF, BH REUBER, ME GERSHWIN  ET AL. 1983. DIELDRIN INDUCED  MALLORY BODIES IN HEPATIC  TUMORS OF MICE OF DIFFERENT
                STRAINS. HEPATOLOGY  3:90-95.

                TENNEKES, HA, AS WRIGHT, KM DIX AND  JH KOEMAN. 1981. EFFECTS OF DIELDRIN, DIET AND BEDDING ON ENZYME  FUNCTION AND TUMOR
                INCIDENCE IN LIVERS OF MALE CF-1 MICE. CANCER RES 41:3615-3620.

                THORPE, E AND AIT WALKER. 1973.  THE  TOXICOLOGY OF DIELDRIN (HEOD).  II. COMPARATIVE LONG-TERM ORAL  TOXICITY STUDIES IN MICE
                WITH  DIELDRIN, DDT, PHENOBARBITONE,  BETA-BHC AND GAMMA-BHC. FOOD COSMET TOXICOL  11:433-442.

                DAVIS,  KJ. 1965. PATHOLOGY REPORT  ON MICE FED ALDRIN, DIELDRIN, HEPTACHLOR OR HEPTACHLOR EPOXIDE FOR  TWO YEARS. INTERNAL
                FDA MEMORANDUM TO DR. AJ LEHMAN,  JULY 19.

                US EPA. 1987. HEALTH EFFECTS ASSESSMENT  FOR DIELDRIN. PREPARED BY THE  OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
                ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
                DC.

DIETHYLSTILBESTEROL                          000056-53-1
        010296  GASS, ET AL. 1964. CARCINOGENIC DOSE-RESPONSE CURVE TO ORAL DIETHYLSTILBESTEROL. J. NATL. CACER  INST. 33:971-977.

                US EPA. 1988. EVALUATION OF THE POTENTIAL CARCINOGENICITY OF DIETHYLSTILBESTEROL. PREPARED BY THE  CARCINOGEN ASSESSMENT GROUP,
                OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, WASHINGTON, DC FOR THE  OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, OFFICE OF
                SOLID WASTE AND REMEDIAL RESPONSE, WASHINGTON, DC.

DIMETHOXYBENZIDINE,  3,3'-                  000119-90-4
        010106  SELLAKUMAR AR, R MONTESANO AND A SAFFIOTI.   1969.  AROMATIC AMINES CARCINOGENICITY IN HAMSTERS.  PROC  AM ASSOC CANCER RES.
                10: 78.

                OSHA/NIOSH (OCCUPATIONAL SAFETY AND  HEALTH ADMINISTRATION/NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY  AND HEALTH). 1980.
                HEALTH HAZARD, ALERT BENZIDINE,  0-TOLIDINE AND 0-DIANISIDINE BASED DYES.  DHHS (NIOSH) PUBL NO. 81-106.

                US EPA. 1987.  HEALTH AND ENVIRONMENTAL  EFFECTS PROFILE FOR 3,3'-DIMETHOXYBENZIDINE. PREPARED BY THE  OFFICE OF HEALTH AND
                ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL  CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
                EMERGENCY RESPONSE, WASHINGTON,  DC.
                                                                                                                                            R3-18

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DIMETHYLANILINE HYDROCHLORIDE,  2,4-    021436-96-4
        010108 WEISBURGER EK,  AB  RUSSFIELD,  F HOMBURGER, ET AL.   1978.  TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR  DERIVATIVES
               FOR  LONG-TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.

               US EPA. 1987.  HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2,4- DIMETHYLANILINE  AND 2,4-DIMETHYLANILINE HYDROCHLORIDE.
               PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,  ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH
               FOR  THE OFFICE  OF  SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC. .

DIMETHYLANILINE,  2,4-                      000095-68-1
        010107 WEISBURGER EK,  AB  RUSSFIELD,  F HOMBURGER, ET AL.   1978.  TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR  DERIVATIVES