United States OSWER (OS-230) OERR 9200.6-303 (92-1)
Environmental Protection ORD (RD-689) NTIS No. PB92-921199
Agency March 1992
svEPA Health Effects Assessment
Summary Tables
Annual
FY 1992
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OHEA ECAO-CIN-821
March 1992
HEALTH EFFECTS ASSESSMENT
SUMMARY TABLES
FY-1992 Annual
Office of Research and Development
Office of Emergency and Remedial Response
U.S. Environmental Protection Agency
Washington, DC 20460
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DISCLAIMER
This report has been prepared by the U.S. Environmental
Protection Agency. The information contained herein has been taken
from final documents prepared by the Office of Health and Environ-
mental Assessment for the Office of Solid Waste and Emergency
Response and the Office of Water, Washington, DC and the Office of
Air Quality Planning and Standards, Research Triangle Park, NC.
These documents were reviewed in accordance with Agency policy and
approved for publication. Mention of trade names or commercial
products does not constitute endorsement or recommendation for use.
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TABLE OF CONTENTS
Page
INTRODUCTION 1
WHAT'S NEW IN THE ANNUAL FY92 HEAST 9
USER'S GUIDE: CHEMICAL TOXICITY AND CARCINOGENICITY ... 21
USER'S GUIDE: RADIONUCLIDE CARCINOGENICITY 35
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) 1-1
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) 2-1
HEAST TABLE 3: CARCINOGENICITY 3-1
HEAST TABLE 4A: RADIONUCLIDE CARCINOGENICITY - SLOPE
FACTORS (IN PICOCURIES) 4A-1
HEAST TABLE 4B: RADIONUCLIDE CARCINOGENICITY - SLOPE
FACTORS (IN BECQUERELS) 4B-1
REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC
TOXICITY (OTHER THAN CARCINOGENICITY) .... Rl-1
REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -
SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) R2-1
REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY ...... R3-1
APPENDIX A: TECHNICAL INFORMATION A-l
111
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INTRODUCTION
This document is the FY92 annual update of the Health Effects
Assessment Summary Tables (HEAST) prepared by EPA's Office of
Health and Environmental Assessment, Environmental Criteria and
Assessment Office, Cincinnati, OH for use at both Superfund and
RCRA sites. It completely replaces all former editions of the
HEAST.
The HEAST is a comprehensive listing consisting almost
entirely of PROVISIONAL RISK ASSESSMENT INFORMATION relative to
oral and inhalation routes for chemicals of interest to Superfund,
the Resource Conservation and Recovery Act (RCRA), and the EPA in
general. These entries in the HEAST are limited to chemicals that
have undergone review and have the concurrence of individual Agency
Program Offices, and each is supported by an Agency reference.
This risk assessment information has not, however, had enough
review to be recognized as high quality, Agency-wide consensus
information.
The Integrated Risk Information System (IRIS) is the Agency's
official repository of Agency-wide consensus chronic human health
risk information. IRIS evaluations are conducted by the Agency's
Work Group Review process, i.e., they have been examined by either
the Reference Dose/Reference Concentration (RfD/RfC) Work Group or
the Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work
Group. These Agency Work Groups conduct a process that leads to
internal Agency scientific consensus regarding risk assessment
information on a chemical. This information is recorded on IRIS,
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is considered to be "Work Group Verified", and does not appear on
the HEAST. Thus, provisional risk assessment information on the
HEAST is subject to possible review and revision by these Agency
Work Groups.
There are two exceptions to the above discussion. The HEAST
also contains information on chemicals that are a part of the
National Ambient Air Quality Standards (NAAQS) or the Drinking
Water Criteria Document (DWCD) series. In each of these cases, the
chemicals are subject to extensive scientific peer review processes
of extremely high quality.
CHEMICAL STATUS DEFINITIONS
Chemicals reviewed by the Agency Work Groups are classified
according to their status as either "verified", "not verifiable",
or "under review". The toxicity values (other than NAAQS or DWCD
values) listed on the HEAST are considered to be "provisional".
The Agency has no official definitions for these terms, but the
HEAST user may interpret them as follows:
Provisional: A toxicity value or a cancer value is
"provisional" if the value has had some form of Agency
review, but it does not appear on the IRIS system. These
values are generated in several ways. Often they are
determined in the course of developing an Agency document
on a chemical or on a class of chemicals. Some have been
generated through the Work Group process, but have not
yet been input to the IRIS system. At the time each
value was derived, all available information on the
chemical was evaluated, the value was calculated using
the most current methodology, and a consensus was reached
on the value by Agency scientists.
These "provisional" values are found on the HEAST. They
do not appear on IRIS.
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Verified: A toxicity value or a cancer value is "Work
Group Verified" if all available information on the value
has been examined by an Agency Work Group, the value has
been calculated using current Work Group methodology, and
a unanimous consensus has been reached on the value by
the Work Group.
These values have been, or shortly will be added to IRIS.
Some "verified" numbers may appear on the HEAST for a
short time until they are loaded onto IRIS. During the
interim, they are considered to be "provisional" values.
Not verifiable: A toxicity value is "not verifiable" if
an Agency Work Group has considered all available data on
a chemical and has unanimously determined that data are
inadequate to generate a value that would be suitable for
inclusion on IRIS. No toxicity value is calculated.
No toxicity values are available for IRIS or the HEAST.
This "not verifiable" status, however, has been, or
shortly will be noted on IRIS, and is often found on the
HEAST, with a pointer to the IRIS system.
Under Review: A toxicity value is "under review" if an
Agency Work Group is in the process of considering all
available data on a chemical. No conclusions have been
drawn thus far by the Work Group. Toxicity values that
have been withdrawn from IRIS by a Work Group will have
this status.
This status may be indicated on IRIS or on the HEAST.
During this time, "provisional" toxicity values may
appear on the HEAST.
In all cases, the status of a chemical may change as new data
become available, and the assessment is revisited.
CAUTION
It is imperative for each user of the HEAST to recognize that
the values listed in the toxicity tables and the cancer table are
generally considered to be PROVISIONAL RISK ASSESSMENT INFORMATION.
The user is referred to IRIS for "Work Group Verified" values. It
is also important to remember that the numbers in these tables
alone tell very little about the adverse effects of a chemical or
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the quality of evidence on which risk assessment information is
based. Original assessment documents must be consulted by users of
the HEAST in order to fully appreciate the strengths and limita-
tions of a specific data base. Original source documents will
allow for the most complete characterization of potential toxicity
associated with the range of exposure pathways generally evaluated
at Superfund and RCRA sites. The Reference Tables point the user
to these sources.
CONTRIBUTORS
•
Chemicals commonly found at RCRA sites as identified by the
Office of Solid Waste's (OSW) Technical Assessment Branch are
included in the HEAST. The Office of Radiation Programs has
provided data on radionuclide carcinogenicity for Tables 4A and 4B
of the HEAST. Finally, the Office of Air Quality Planning and
Standards (OAQPS) has provided information on chemicals for which
Air Quality Criteria Documents and National Ambient Air Quality
Standards have been developed.
CHEMICALS LISTED
Most of the chemicals included on the toxicity tables and
carcinogenicity table are those for which at least one of the
following EPA documents has been written: Health Effects Assess-
ment Document (HEA), Health and Environmental Effects Profile
(HEEP), Health and Environmental Effects Document (HEED), Health
Assessment Document (HAD), Air Quality Criteria Document (AQCD),
Drinking Water Criteria Document (DWCD). A description of each is
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provided in Appendix .A, Section I. In a few cases, the values are
supported by other written material, such as Work Group meeting
notes or Carcinogen Assessment Group (CAG) Profiles. Radionuclides
included are those believed to be most commonly encountered at
Superfund sites.
The names of criteria pollutants that are regulated as
National Ambient Air Quality Standards (NAAQS) under the Clean Air
Act are listed in the main body of the HEAST, but the actual
criteria are included as Section V of Appendix A: Technical
Information. The NAAQS were not included in the tables in order to
distinguish them from the reference concentration ([RfC]) values.
*
The NAAQS and [RfC]s represent different levels of review and
different methods of calculation and thus, must be interpreted and
used differently.
HIERARCHY OF SOURCES
It is recognized that at any point in time there may be
multiple old and new Agency documents or data bases that present
different values on a specific chemical. For chemicals other than
those represented by the NAAQS or DWCDs, the following hierarchy of
sources is recommended in evaluating chemical toxicity for
Superfund sites:
1. The Agency's Integrated Risk Information System (IRIS) and
cited references. Changes are made in this data base on
a monthly basis, but there may be data gaps. Call IRIS
USER SUPPORT at 513/569-7254 (FTS 684-7254) for further
information.
2. The Health Effects Assessment Summary Tables (HEAST) and
cited references.
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3. Consultation with the Superfund Health Risk Technical
Support Center (TSC) at (513)569-7300; FTS 684-7300.
4. Do not consult either the toxicity tables (Appendix A) in
the Superfund Public Health Evaluation Manual (SPHEM, U.S.
EPA, 1986) or the September 1988 Public Health Risk
Evaluation Data Base (PHRED) as these sources are likely
to contain numerous values that have since become out-of-
date.
QUESTIONS
Chemical Toxicity and Carcinogenicity
Regional EPA Superfund Staff may direct questions regarding
the contents of the chemical toxicity and carcinogenicity tables on
the HEAST (e.g., chemicals not covered, chemicals with pending
[RfD]s) to EPA's Superfund Health Risk Technical Support Center
(TSC) in Cincinnati, OH at (513) 569-7300 (FTS 684-7300).
Questions from other users must be submitted to the TSC in writing
and must contain the following information:
- Superfund site name, site location and twelve-digit
site number;
- Name and phone number of the site Remedial Project
Manager (RPM) or Regional Risk Assessor/Toxicologist;
- Detailed description of the risk assessment related
question.
Please send requests via mail or FAX to:
Superfund Health Risk Technical Support Center
US EPA
26 W. ML King Dr.
Environmental Criteria and Assessment Office
MS 114
Cincinnati, OH 45268
FAX#: (513) 569-7159
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RCRA Chemicals
Questions about RCRA chemicals may be addressed by calling the
Health Assessment Section of the Office of Solid Waste at (202)
260-4761 (FTS 260-4761).
Radionuclide Carcinogenicity
Questions concerning radionuclide carcinogenicity should first
be addressed by contacting the appropriate Regional Radiation
Program Manager. A listing of these managers and several contacts
in the Office of Radiation Programs can be found in the User's
Guide - Radionuclide Carcinogenicity on pages 46-48.
REFERENCES
Most cited Agency references (e.g., HEAs, HEEPs, HEEDs), are
(or will soon be) available through the National Technical
Information Service (NTIS), 5285 Port Royal Road, Springfield, VA
22161 (703/487-4650 or 800/336-4700). Carcinogen Assessment Group
(CAG) Profiles cited in Table 3 are available through the RCRA
docket (202/260-9327).
ORDERING INFORMATION
Limited copies of the HEAST are available for EPA Superfund
staff, State Superfund programs and other Federal agencies working
on Superfund sites, and EPA contractors working for the EPA Super-
fund program. Users in these groups can call Syracuse Research
Corporation (703) 769-1880 to be put on the mailing list.
EPA's Office of Solid Waste (OSW) requests that their users
(i.e., OSW staff, contractors, State solid waste programs) call the
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Health Assessment Section (202) 260-4761 (FTS 260-4761) to obtain
copies of the HEAST. Regional OSW staff are reminded that copies
are sent to all EPA Regional libraries.
Users of the HEAST in EPA's Office of Air and Radiation and
State air programs should call Rick Mattick of EPA's Office of Air
Quality Planning and Standards at (919) 541-3990.
All other users must purchase the document from:
National Technical Information Service (NTIS)
5285 Port Royal Road
Springfield, VA 22161
(703) 487-4630
For ordering information, call the NTIS Subscriptions
Department at (703)487-4630. NTIS normally ships 4th class United
States mail. Therefore, users may wish to consult with NTIS
concerning the use of an overnight delivery service. The NTIS
order number is PB92-921100.
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WHAT'S NEW IN THE FY92 HEAST
GENERAL CHANGES - CHEMICAL TOXICITY AND CARCINOGENICITY
Several changes in presentation, information, and data
availability have been made since the FY91 version of the HEAST.
The most significant change is that IRIS values will no longer be
found in the HEAST. Instead of listing the IRIS values associated
with a given chemical, these tables will direct the user to IRIS
for that information. This modification is in keeping, with the
policy of the Office of Emergency and Remedial Response that risk
assessors consult IRIS as their first source for toxicity values.
The changes in this version of the HEAST reflect changes in
IRIS through January 1, 1992. It is also current with RfD/RfC and
CRAVE Work Group activities through this same date.
The information contained in each table and their designations
have been changed as follows:
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER
THAN CARCINOGENICITY)
Table 1, formerly Table A, lists subchronic and chronic
non-cancer toxicity values that were calculated using the
current methodology practiced by the RfD/RfC Work Group.
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
Table 2 is a new table that lists subchronic and chronic
non-cancer toxicity values that are found in Agency
documents, but were calculated by alternative methods
that are not currently practiced by the RfD/RfC Work
Group. These values are considered to be adequate
provisional values for risk assessment purposes at
Superfund and RCRA sites, but are subject to being
reviewed by the RfD/RfC Work Group and revised when
necessary to reflect current work group practices.
HEAST TABLE 3: CARCINOGENICITY
Table 3, formerly Table B, lists carcinogenicity values
that were calculated using the current methodology of the
CRAVE Work Group.
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HEAST TABLES 4A AND 4B: RADIONUCLIDE CARCINOGENICITY -
SLOPE FACTORS
Tables 4A and 4B, formerly Table C, list ingestion,
inhalation and external exposure carcinogenicity slope
factors for radionuclides in two equivalent, but differ-
ent units, picocuries and becquerels, respectively.
HEAST TABLE 1 REFERENCES: SUBCHRONIC AND CHRONIC
TOXICITY (OTHER THAN CARCINOGENICITY)
The references for Table 1 are now numerically coded to
associate each toxicity value clearly with its corre-
sponding reference.
HEAST TABLE 2 REFERENCES: ALTERNATE METHODS - SUBCHRONIC
AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
The references for Table 2 are now numerically coded to
associate each toxicity value clearly with its corre-
sponding reference.
HEAST TABLE 3 REFERENCES: CARCINOGENICITY
The references for Table 3 are now numerically coded to
associate each toxicity value clearly with its corre-
sponding reference.
The format of Tables 1, 2 and 3 has been changed to allow for
the inclusion of more information. Enhancements of the HEAST
include the addition of the Chemical Abstract Service Registry
Number (CASRN) for each chemical, the identification of the dose
level (e.g., NOAEL, meaning "No-Observed-Adverse-Effect Level") on
which the toxicity value is based, the identification of target
organs, and a description of the critical effects and cancers.
Additionally, footnotes at the end of the tables have been replaced
by presenting relevant information regarding a specific toxicity
value in the comment section after each chemical entry.
The nomenclature has also changed. Brackets are now placed
around the names of toxicity and carcinogenicity values to distin-
guish these "provisional" values from information on IRIS. The
following names are affected: RfD to [RfD], RfC to [RfC], slope
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factor to [slope factor], EPA group to [EPA Group] and unit risk to
[unit risk].
Finally, a technical appendix (Appendix A) has also been
developed with the following sections available for information:
I. Data Sources and Selection Criteria Used in HEAST
II. Dose Conversions on HEAST
III. Chemical Name and Chemical Abstracts Service
Registry Number Cross Reference
IV. Effect Level Definitions
V. National Ambient Air Quality Standards (NAAQS)
CHEMICAL-SPECIFIC CHANGES - CHEMICAL TOXICITY AND CARCINOGENICITY
The major chemical-specific changes that have occurred on
Tables 1, 2 and 3 since the FY91 HEAST are listed below. Due to
the large extent of modifications, consistency changes that were
made in these tables are not detailed in this section. For
example, modifications on the description of the administered
doses, critical effects, critical studies, and effect levels are
not discussed.
Recent activity by the RfD/RfC and CRAVE Work Groups has
changed the status of several chemicals in Tables 1, 2 and 3. For
chemicals that are currently under review by the Work Groups, a
comment simply indicates that the toxicity value is under review
and may be subject to change.
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A. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 1: SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
1. Additional Chemicals listed on Table 1
Boron trifluoride Carbon monoxide
Formaldehyde Heptachlor epoxide
Phorate Selenium
Strontium, stable Sulfur dioxide
Tetrachloroethane, 1,1,1,2- Warfarin
2. Chemicals that were considered to be Not Verifiable for the
Chronic Inhalation RfC by the RfD/RfC Work Group
Acrylamide Benzidine
Biphenyl, 1,1- Carbaryl
Cresol, m- Cresol, o-
Cresol, p- Dinitrophenol, 2,4-
Ethylene diamine Hexachloroethane
Isophorone Methyl isocyanate
Phenol Propylene glycol
Propylene glycol monoethyl ether Trichlorophenol, 2,4,5-
Trichlorophenol, 2,4,6- Xylene, m-
Xylene, mixture Xylene, o-
Xylene, p-
3. Chemicals that were withdrawn from IRIS by the RfD/RfC Work
Group (provisional values remain on Table 1)
Barium cyanide Cresol, p-
Formic acid Methyl ethyl ketone
Methyl isobutyl ketone Selenourea
Simazine Trichloroethane, 1,1,1-
Trichlorobenzene,1,2,4-
4 . Chemicals listed in the National Ambient Air Quality Standards
(NAAOS) (Appendix A)
Carbon monoxide
Lead (and Lead compounds)
Nitrogen dioxide (Nitrogen oxide, Nitric oxide)
Ozone
Particulate matter
Sulfur dioxide (Sulfur oxide)
5. Chemicals that are also listed in Table 2: Alternate Methods -
Subchronic and Chronic Toxicitv (Other Than Carcinogenicity)
Acetone cyanohydrin Acetonitrile
Acetophenone Barium
Chloro-1,3-butadiene Chlorobenzene
Cyclopentadiene Dichlorobenzene, 1,2-
Dichlorodifluoromethane Dichloroethane, 1,1-
Dicyclopentadiene Ethoxyethanol acetate,2-
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Ethylene diamine Furfural
Methacrylonitrile Methoxyethanol acetate, 2-
Methyl acrylate Methyl ethyl ketone
Methyl isobutyl ketone Methyl styrene, alpha-
Methyl styrene (mixed isomers) Methylene bromide
Nitrobenzene Trichlorobenzene, 1,2,4-
Trichloroethane, 1,1,1- Trichlorofluoromethane
6. Additional Changes in Table 1 include:
Acetone cyanohvdrin
The chronic [RfC] value was moved to Table 2. (See section B
below.)
Acrolein
The subchronic and chronic oral [RfD]s were added to reflect
the 1985 KEEP. The subchronic inhalation [RfC] was changed to
reflect the recently verified chronic RfC on IRIS.
Aldicarb
The subchronic oral [RfD] was changed to reflect the conversion
from the recently verified chronic RfD on IRIS.
Ammonia
The subchronic inhalation [RfC] was changed to reflect the
recently verified chronic RfC on IRIS.
Arsenic, inorganic
The subchronic oral [RfD] was changed to reflect the adoption
of the recently verified chronic RfD on IRIS.
Barium
The subchronic oral [RfD] was added to reflect the adoption of
the recently verified chronic oral RfD on IRIS.
Barium cyanide
The subchronic and chronic oral [RfD] values reflect the 1985
Drinking Water Criteria Document. The chronic oral [RfD] was
withdrawn from IRIS.
Benzyl alcohol
The uncertainty factor for the subchronic oral [RfD] was
changed to reflect the 1989 HEED. The [RfD] value remains the
same.
Boron
The subchronic and chronic inhalation [RfC]s were added to
reflect the 1991 HEED.
Bromomethane
The chronic inhalation [RfC] was changed to reflect the value
under review by the RfD/RfC Work Group (1991).
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Captan
Expression of the subchronic oral [RfD] was changed from one to
two significant digits to reflect the presentation of the
chronic RfD on IRIS.
Chlorophenol. 2-
The subchronic oral [RfD] and its uncertainty factor were
changed because an uncertainty factor of 10 given for sub-
chronic to chronic conversion was removed.
Chloropropane. 2-
The chronic and subchronic inhalation [RfC]s were changed to
reflect the 1987 HEED.
Chromium(III)
The inhalation [RfC]s were removed pending resolution of the
Agency's position. The subchronic [RfD] was changed to be
consistent with information on IRIS.
Chromium(VI)
The inhalation [RfC]s were removed pending resolution of the
Agency's position.
Dichloropropane. 1.2-
The subchronic inhalation [RfC] was added to reflect the
conversion from the recently verified chronic RfC on IRIS.
Diethylformamide
The chronic and subchronic oral [RfD]s were changed to reflect
the 1986 KEEP.
Dimethyl phthalate
The chronic and subchronic oral [RfD] values were changed to
reflect the 1987 HEEP. These values are also under review by
the Work Group.
Endosulfan
The subchronic oral [RfD] was changed to reflect the adoption
of the chronic RfD on IRIS.
Endrin
The subchronic oral [RfD] was changed to reflect the adoption
of the chronic RfD on IRIS.
Epichlorohydrin
The subchronic oral [RfD] was changed to reflect the adoption
of the chronic RfD on IRIS. The chronic inhalation [RfC] was
changed to reflect the value under review by the RfD/RfC Work
Group (1991).
Ethoxyethanol. 2-
The subchronic inhalation [RfC] was changed because an uncer-
tainty factor of 10 for subchronic to chronic conversion was
removed.
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Ethyl ether
The subchronic oral [RfD] was changed to reflect the conversion
from the recently verified chronic RfD on IRIS.
Ethylene thiourea
The subchronic oral [RfD] was added to reflect the recently
verified chronic RfD on IRIS.
Lead
The user is asked to refer to IRIS.
Lead alkyls
The oral [RfD] values were removed and the user is asked to
refer to IRIS.
Malononitrile
The uncertainty factor for the chronic oral [RfD] was changed
to reflect the 1986 KEEP. The [RfD] value remains the same.
Methomyl
Expression of the subchronic oral [RfD] was changed from one to
two significant digits to reflect the presentation of the
chronic RfD on IRIS.
Methylcyclohexane
The subchronic and chronic inhalation [RfC]s were added to
reflect the 1991 HEED.
Methylenediphenyl isocyanate, 4.4'-
The chronic inhalation [RfC] was changed to reflect the value
under review by the RfC/RfD Work Group (1990). The subchronic
[RfC] was adopted from the chronic [RfC].
Molybdenum
The chronic oral [RfD] and the subchronic oral [RfD] were
changed to reflect the value under review by the RfD/RfC Work
Group (1991).
Naphthalene
The chronic oral [RfD] was changed to reflect the evaluation by
the RfD/RfC Work Group (1989). For the chronic [RfD], an
uncertainty factor of 1000 represents 10 each for intraspecies
and interspecies extrapolation and cataract formation. The
subchronic [RfD] was adopted from the chronic [RfD].
Nitroaniline. o-
The oral and inhalation values were added to reflect the 1991
HEED.
Nitrobenzene
The subchronic and chronic [RfC]s were moved to Table 2. (See
section B below.)
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Phenylenediamine, p-
The chronic oral [RfD] was added to reflect the 1985 KEEP.
Phosphine
The uncertainty factors for the subchronic and chronic inhala-
tion [RfC]s were changed to reflect the 1989 HEED. The [RfC]
values remain the same.
Profluralin
The uncertainty factors for the subchronic and chronic oral
[RfD]s were changed to reflect the 1984 HEEP. The [RfD] values
remain the same.
Pronamide
Expression of the subchronic oral [RfD] was changed from one to
two significant digits to reflect the presentation of the
chronic RfD on IRIS.
Propylene glycol monmomethyl ether
The subchronic inhalation [RfC] was changed to reflect the
conversion from the recently verified chronic RfC on IRIS.
Selenious acid
The subchronic oral [RfD] was changed to reflect the recently
verified chronic RfD on IRIS.
Silver
The subchronic oral [RfD] was changed to reflect adoption of
the recently verified chronic RfD on IRIS.
Terbufos
The subchronic and chronic oral [RfD] were changed to reflect
the 1987 HAD.
Thallium (in soluble salts)
The oral [RfD] values were removed from Table 2 and the user is
asked to refer to IRIS for other thallium salts.
Thiram
The chronic oral RfD reflects input on IRIS. The subchronic
oral [RfD] reflects the 1989 HEED.
Toluene
The chronic inhalation [RfC] was changed to reflect the value
under review by the RfD/RfC Work Group.
Trichloro-1.2.2-trifluoroethane. 1.1,2-
The chronic RfD reflects IRIS input. The subchronic [RfD]
value was from a recent source document, the 1990 HEED.
Trichlorobenzene. 1,2,4-
The subchronic and chronic oral [RfD] values reflect recent
evaluation by the Work Group (1991). The chronic oral RfD was
withdrawn from IRIS.
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B. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 2: ALTERNATIVE
METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY)
1.
Chemicals with values moved from Table 1.
Table 2 was created to list subchronic and chronic non-cancer
toxicity values that are found in Agency documents, but were
calculated by alternative methods that are not currently practiced
by the RfD/RfC Work Group. These values are considered to be
adequate provisional values for risk assessment purposes for
Superfund and RCRA sites, but are subject to being reviewed by the
RfD/RfC Work Group and revised when necessary to reflect current
work group practices. The following chemicals had values that
could be categorized as such, and these were moved to Table 2.
Acetone cyanohydrin
Acetophenone
Chloro-1,3-butadiene
Cyclopentadiene
Dichlorodi fluoromethane
Dicyclopentadiene
Ethylene diamine
Methacrylonitrile
Methyl aerylate
Methyl isobutyl ketone
Methyl styrene (mixed isomers)
Nitrobenzene
Trichloroethane, 1,1,1-
Acetonitrile
Barium
Chlorobenzene
Dichlorobenzene, 1,2-
Dichloroethane, 1,1-
Ethoxyethanol acetate,2-
Furfural
Methoxyethanol acetate, 2-
Methyl ethyl ketone
Methyl styrene, alpha- .
Methylene bromide
Trichlorobenzene, 1,2,4-
Trichlorofluoromethane
2. Additional Changes in Table 2 include:
Acetone cyanohydrin
The chronic inhalation [RfC] was changed because the uncer-
tainty factor in the 1988 HEED document was incorrectly cited.
An uncertainty factor of 10 was added for subchronic to chronic
conversion. The value was formerly listed in Table 1.
Nitrobenzene
The uncertainty factors for the subchronic and chronic inhala-
tion [RfC]s were changed to reflect the 1987 HEA. The [RfC]
values remain the same. The values were formerly listed in
Table 1.
C. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 3:
1. Additional Chemicals Listed on Table 3
Ethylnitrosourea
Hexachlorocyclohexane, delta-
Hexachlorocyclohexane, epsilon-
Methylnitrosourea
CARCINOGENICITY
-17-
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Additional Changes to Table 3 include;
Alachlor
The oral [slope factor] was changed to reflect the evaluation
by the CRAVE Work Group (1988).
Benzo[a]pyrene
The oral [slope factor] and [unit risk] was added to reflect
the values under review by the CRAVE Work Group (1991).
Bisf2-Chloroisopropyl) ether
The inhalation [slope factor] and [unit risk] were changed to
reflect a 50% absorption factor for the conversion from the
oral [slope factor].
Bromoethene
The inhalation [unit risk] was changed to reflect the conver-
sion from the inhalation [slope factor].
Carbazole
The oral [unit risk] was changed to reflect conversion from the
oral [slope factor].
Carbon Tetrachloride
The inhalation [slope factor] was changed to reflect a 40%
absorption factor for the conversion from the oral [slope
factor].
Chloronitrobenzene. o-
The oral [unit risk] was changed to reflect the conversion from
the oral [slope factor].
Chrysene
A footnote was added to refer the reader to the RCRA program
for numeric risk assessments for RCRA activities.
Dibromo-3-chloropropane. 1.2-
The oral and inhalation [slope factor]s and [unit risk] values
were changed to reflect values under review by the CRAVE Work
Group (1990). The oral values were also cited in the Drinking
Water Criteria Document (1989).
1.1-Dimethylhydrazine
The oral and inhalation [slope factor] and [unit risk] values,
as well as the cancer [EPA group] classification, were changed
to reflect values under review by the CRAVE Work Group (1988).
1.2-Dimethylhydra2ine
The oral and inhalation [slope factor] and [unit risk] values,
as well as the cancer [EPA group] classification, were changed
to reflect values under review by the CRAVE Work Group (1990).
Direct Black 38
The oral [slope factor] was changed to reflect the 1987 KEEP.
-18-
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Direct Blue 6
The oral [slope factor] was changed to reflect the 1987 KEEP.
Ethylene Oxide
The oral [slope factor] and [unit risk] were added to reflect
the 1984 HEEP.
Ethylene thiourea
The oral [slope factor] and [unit risk] were changed to reflect
the recent OPP evaluation of newer data.
Furium
The oral [unit risk] was changed to reflect the conversion from
the oral [slope factor].
Methvlaniline hvdrochloride. 2-
The oral [unit risk] was changed to reflect conversion from the
oral [slope factor].
Propylene oxide
An inhalation [slope factor] was added.
Styrene
The quantitative risk assessment values were removed pending
resolution of the Agency's position. Contact the Superfund
Health Risk Technical Support Center for more information (see
page 6).
Tetrachloroethylene
The quantitative risk assessment values were removed pending
resolution of the Agency's position. Contact the Superfund
Health Risk Technical Support Center for more information (see
page 6).
Toluidine. p-
The oral [unit risk] was changed to reflect conversion from the
oral [slope factor].
Trichloroethylene
The quantitative risk assessment values were removed pending
resolution of the Agency's position. Contact the Superfund
Health Risk Technical Support Center for more information (see
page 6).
Vinvl Chloride
The inhalation [slope factor] was added to reflect conversion
from the inhalation [unit risk].
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D. CHANGES ON HEAST TABLES 4A AND 4B: RADIONUCLIDE CARCINO-
GENICITY - SLOPE FACTORS
1. Ingestion, inhalation and external exposure slope factors for
radionuclides, formerly reported in HEAST Table C, are now
listed in the new HEAST Tables 4A (in customary activity units
of picocuries (pCi)) and 4B (in the International System (SI)
activity units of becquerels (Bq)).
2. Radionuclide data have been rearranged alphabetically by
element for easier reference.
3. Over 200 new radionuclides have been added to provide a more
comprehensive data set for risk calculations.
4. Additional guidance and slope factor values have been included
for important decay chain radionuclides: A radionuclide marked
with the suffix "+D" in Tables 4A and 4B indicates that its
inhalation, ingestion and external exposure slope factors
include the added risks from associated radioactive decay chain
products in equilibrium with the parent in the environment.
(Slope factors for all radionuclides always account for decay
products created within the body after intake.)
5. A Chemical Abstract Service Reference Number (CASRN) has been
assigned to each radionuclide for identification and reporting
accuracy..
6. Radioactive half-lives have been added for reference.
7. Pathway specific unit risk values are no longer reported.
Instead, a list of EPA documents that provide guidance on the
use of slope factors in radiation risk assessment calculations
has been included in the User's Guide.
8. Slope factors for external exposure to radionuclides in soil
have been recalculated. New values are expressed in terms of
lifetime cancer incidence risk per unit exposure to a source of
uniform activity per unit mass in soil (e.g., risk/yr per
pCi/g), assuming a thick layer of uniformly contaminated soil.
[The previous slope factors were for exposure to a source of
uniform activity per unit surface area.]
9. Slope factors for inhalation and ingestion have been revised to
be consistent with recent EPA Science Advisory Board (SAB)
recommendations for the regulation of radionuclides in drinking
water. These changes, which primarily affect alpha-emitters,
include a reduction in the GI absorption factor (f^) for uranium
radionuclides from 0.2 to 0.05; incorporation of sinus carci-
nomas in Ra-226 risk estimates; adjustment in the doses and
resultant risks of bone cancer and leukemia risk for Ra-228; a
reduction in the leukemia risk from alpha radiation; and a
recalculation of the urinary system cancer risk based on both
the dose to the kidneys and the urinary bladder.
-20-
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USER'S GUIDE: CHEMICAL TOXICITY
The Health Effects Assessment Summary Table summarizes
provisional toxicity and cancer values as well as values developed
for the NAAQS and DWCD chemicals. The provisional status of the
toxicity and cancer values is indicated by placing brackets around
the title of the value. These include provisional reference
concentrations ([RfC]) and provisional reference doses ([RfD]) for
toxicity from subchronic and chronic inhalation and oral exposure
(Tables 1 and 2) and provisional slope factors ([slope factor]),
provisional cancer classifications ([EPA Group]) and provisional
unit risk values ([unit risk]) for carcinogenicity, based on
lifetime inhalation and oral exposure (Table 3). Brackets should
be included with the acronym whenever a user quotes the value in an
assessment document, and the provisional nature of the value should
be noted. A more complete discussion of how Superfund develops and
considers the toxicity assessment in hazardous waste sites is
presented in Chapter 7 of Risk Assessment Guidance for Superfund:
Human Health Evaluation Manual, Part A.
The references listed for each chemical in the Reference
Tables for Tables 1, 2 and 3 represent the study or studies that
are the basis for the [RfC], [RfD], [slope factor], [EPA Group], or
[unit risk], as well as the EPA reference that is the source of the
Agency analysis or risk assessment information. In some cases,
additional EPA documents are also listed as a source of information
on the chemical. Work Group verified values found on IRIS are not
-21-
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found on the HEAST, but are indicated in the tables by the word
"IRIS" in place of the number.
The following documents cited in this section may be obtained
from their respective sources:
From the Center for Environmental Research Information
(513)569-7562.
Risk Assessment Guidance: Volume 1, Human Health
Evaluation Manual, Part A. EPA/540/1-89/002.
Air Quality Criteria Documents.
From the National Technical Information Service (NTIS)
(703)487-4780.
Interim Methods for Development of Inhalation Reference
Doses. EPA/600/8-88/006F. Order number PB90-145723.
The price is $31.00.
TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINO-
GENICITY)
The [RfC] or [RfD] is a provisional estimate (with uncertainty
spanning perhaps an order of magnitude) of the daily exposure to
the human population (including sensitive subgroups) that is likely
to be without an appreciable risk of deleterious effects during a
portion of the lifetime, in the case of a subchronic [RfC] or
[RfD] , or during a lifetime, in the case of a chronic [RfC] or
[RfD]. The [RfC] and [RfD] values are listed in Tables 1 and 2 in
columns with the headings "Subchronic11 and "Chronic". The
critical dose or concentration level is usually a No-Observed-
Adverse-Effect Level (NOAEL) or a Lowest-Observed-Adverse-Effect
Level (LOAEL) (See Appendix A, Section IV: Effect Level Defini-
tions, for more information) . The [RfC] or [RfD] is derived by
-22-
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dividing the NOAEL or LOAEL by an uncertainty factor (UF) times a
modifying factor (MF):
[RfC] or [RfD] = NOAEL or LOAEL
UF x MF
In Tables 1 and 2, the information listed is the following:
Chemical
Level
Dose
Route
Species
Experiment Length
Target
Critical Effect
Subchronic [RfC]
UF
Subchronic [RfD]
UF
Chronic [RfC]
UF
Chronic [RfD]
UF
Reference
= Chemical Name/CASRN
= Effect Level
= Administered Dose or Concentration
= Route of Administration
= Tested Species
= Length of Exposure
= Target Organ(s) Affected at Critical Level
= Effect(s) Observed at Critical Level
= Subchronic Inhalation [Reference Concen
tration]
= Uncertainty Factor for the Subchronic
Inhalation [Reference Concentration]
= Subchronic Oral [Reference Dose]
= Uncertainty Factor for the Subchronic Oral
[Reference Dose]
= Chronic Inhalation [Reference Concentration]
= Uncertainty Factor for the Chronic Inhalation
[Reference Concentration]
= Chronic Oral [Reference Dose]
= Uncertainty Factor for the Chronic Oral
[Reference Dose]
= Reference Identification Number for All
Toxicity Values on the Same Line.
An example of this information is shown in Figure 1, HEAST Table 1:
Chemical
Level
Dose
Route
Species
Experiment Length
Target
Critical Effect
Subchronic [RfC]
UF
Subchronic [RfD]
UF
Chronic [RfC]
UF
Chronic [RfD]
UF
Reference
= GLYCIDALDEHYDE/000765-34-4
= NOAEL
= 10 PPM
= INHALATION: INTERMITTENT
= RAT
= 12 WEEKS
= WHOLE BODY, BLOOD, KIDNEY
= DECREASED WEIGHT GAIN, HEMATOPOIETIC EFFECTS,
EFFECTS
= 1E-2 mg/cu.m
= 300
= 4E-3 mg/kg/day
= 300
= 1E-3 mg/cu.m
= 3000
= IRIS
= IRIS
= 005968
-23-
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FIGURE 1
Example Data and References for Chemical Toxicity
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
GLYCIDALDEHYDE
NOAEL 10 PPM
INHALATION:
INTERMITTENT
RAT
12 WEEKS
000765-34-4
WHOLE BODY
BLOOD
KIDNEY
CRITICAL EFFECT
DECREASED WEIGHT GAIN
HEMATOPOIETIC EFFECTS
EFFECTS
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD]
(mg/cu m) (ing/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
1E-2
300
4E-3
300
1E-3
3000
IRIS
January 1992
REFERENCE
005968
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
GENERAL COMMENT: ALSO SEE TABLE 3: CARCINOGENICITY.
REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
January 1992
GLYCIDALDEHYDE 000765-34-4
005968 HINE CH, RJ GUZMAN, MK DUNLAP, R LIMA AND GS LOQUVAM. 1961. STUDIES ON THE TOXICITY OF GLYCIDALDEHYDE. ARCH ENVIRON HEALTH.
2: 23-30.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENTFOR GLYCIDALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
-------
Notice that a Chronic RfD for Glycidaldehyde is available on IRIS,
so it is not listed here. Also notice that there are footnotes for
this chemical that indicate a route-to-route extrapolation was
performed and that there is information available on Table 3:
Carcinogenicity.
Also given in Figure 1 is an example of the References for
Table 1 for the same chemical. The reference is identified by the
chemical name (Glycidaldehyde), the CASRN (00765-34-4), and the
reference number that links it with the toxicity values (005968).
The uncertainty factor used in calculating the [RfC] or [RfD]
reflects scientific judgment regarding the various types of data
used to estimate [RfC] or [RfD] values. An uncertainty factor of
10 is usually used to account for variation in human sensitivity
among populations. An additional 10-fold factor is usually used to
account for each of the uncertainties assumed when extrapolating
from animal data to humans, when extrapolating from a LOAEL to a
NOAEL, and when extrapolating from subchronic to chronic exposure.
In order to reflect professional assessment of the uncertainties of
the study and the data base not explicitly addressed by the above
uncertainty factors (e.g., completeness of the overall data base),
an additional uncertainty factor or modifying factor ranging from
greater than 0 to less than or equal to 10 is applied. The default
•
value for this modifying factor is 1.
For chemicals for which a chronic [RfC] or [RfD] is presented
in Tables 1 and 2, a subchronic [RfC] or [RfD] is usually derived,
if not previously derived in the Agency documents that originally
addressed the chemical. Subchronic toxicity values are not
evaluated by the RfD/RfC Work Group. The subchronic [RfC] or [RfD]
is derived in either of two ways: 1) If an uncertainty factor was
-25-
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used to account for extrapolation from subchronic to chronic
exposure in the derivation of the chronic [RfC] or [RfD] , then, the
subchronic [RfC] or [RfD] is derived from the same benchmark
concentration or dose without applying the uncertainty factor for
subchronic to chronic exposure extrapolation. 2) If the chronic
[RfC] or [RfD] was derived without use of an uncertainty factor for
extrapolating from subchronic to chronic exposure (e.g., if chronic
data were available), then, the chronic [RfC] or [RfD] is adopted
as the subchronic [RfC] or [RfD].
Tables 1 and 2 list the uncertainty factor and modifying
factor, multiplied together, to form a single factor under the
heading "Uncertainty Factor." For example, the uncertainty factor
of 3000 listed for the chronic inhalation [RfC] for Glycidaldehyde
reflects an uncertainty factor of 1000 (10 for human sensitivity,
10 for extrapolation from animal to human, and 10 for extrapolation
from subchronic to chronic) and a modifying factor of 3 (for an
inadequate data base); the uncertainty factor of 500 listed for
the subchronic oral [RfD] for cyanide reflects an uncertainty
factor of 100 (10 for human sensitivity, and 10 for extrapolation
from animal to human) and a modifying factor of 5 (to account for
•
tolerance to cyanide when ingested by food rather than administra-
tion by gavage or by drinking water).
[RfC] and [RfD] values are specific for the route of exposure
for which they are listed on Tables 1 and 2. In the few instances
where an [RfD] or [RfC] has been determined from another exposure
route, route-to-route extrapolation is indicated by a footnote.
-26-
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The current methodology for the derivation of inhalation RfCs
is detailed in the document, "Interim Methods for Development of
Inhalation Reference Doses" (U.S. EPA, 1990, EPA/600/8-88/066F).
These methods are different from those used for oral RfDs because
of (1) the dynamics of the respiratory system and its diversity
across species, and (2) differences in the physicochemical
properties of contaminants (such as the size and shape of a
particle or whether the contaminant is an aerosol or a gas) .
Parameters such as deposition, clearance mechanisms and the
physicochemical properties of the inhaled agent are considered in
the determination of the effective dose delivered to the target
organ.
An RfC value calculated using this interim methodology is
generally reported as a concentration in air (mg/m3) , although it
may be converted to a corresponding inhaled dose (mg/kg/day) by
dividing by 70 kg (an assumed human body weight), multiplying by
20 m3/day (an assumed human inhalation rate), and adjusting by an
appropriate absorption factor. This conversion, however, may often
be technically incorrect, and the appropriateness of doing this
must be evaluated on a case-by-case basis. It is recommended that
HEAST users that plan to use this technique read a further
discussion of the difficulties inherent in this dose conversion
that can be found in Appendix A, Section II: Dose Conversions On
HEAST.
Inhalation [RfC] values reported in HEAs and early HEEDs that
were finalized prior to the implementation of the interim methods
were calculated using methods similar in concept to those used for
-27-
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oral [RfD]s. These values are reported both as a concentration in
air (in mg/m3 for continuous, 24 hours/day exposure) under the
column [RfC], and as a corresponding inhaled dose (in mg/kg/day) in
the footnotes called, Chronic (Subchronic) [RfC] Comment. These
chemicals are listed in Table 2: Alternate Methods - Subchronic and
Chronic Toxicity (Other Than Carcinogenicity).
[RfD] values for oral exposure are reported as mg/kg/day. An
oral [RfD] value can be converted to a corresponding concentration
in drinking water, assuming human body weight of 70 kg and water
consumption of 2 £/day, as follows:
mg/£ in water = oral FRfD] (in mg/kg/day) x 70 kg
2 £/day
The [RfC] or [RfD] is used as a reference point for gauging
the potential effects of other exposures. Usually, exposures that
are less than the [RfC] or [RfD] are not likely to be associated
with health risks. As the frequency of exposures exceeding the
[RfC] or [RfD] increases and as the size of the excess increases,
the probability increases that adverse health effects may be
observed in a human population. Nonetheless, a clear distinction
that would categorize all exposures below the [RfC] or [RfD] as
"acceptable" (risk-free) and all exposures in excess of the [RfC]
or [RfD] as "unacceptable" (causing adverse effects) cannot be
made. In addition, [RfC] and [RfD] values, and particularly those
with limitations in the quality or quantity of supporting data, are
subject to change as additional information becomes available.
When [RfC] or [RfD] values are listed in Tables 1 or 2 for
chemicals that are carcinogens, a footnote will refer to Table 3 if
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additional information concerning carcinogenicity is available in
that table. [RfC] .and [RfD] values that have been derived for
carcinogens are based on noncancer endpoints only and should not be
assumed to be protective against carcinogenicity.
TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
Chemicals are listed in Table 2 when the [RfD] or [RfC] was
derived from alternative methods that are not currently practiced
by the RfD/RfC Work Group. The table consists primarily of
inhalation [RfC] values determined from methodology that does not
follow the interim inhalation methods adopted by the Agency, and
[RfC] or [RfD] values based on route-to-route extrapolation with
inadeguate pharmacokinetic and toxicity data. A footnote is added
to each chemical to provide a short explanation of the specific
methodology used in calculating these provisional toxicity values.
Most of these toxicity values were formerly listed in Table 1. In
some instances, the chemical may be listed in both Tables 1 and 2
if the chemical has more than one toxicity value. Table 2 follows
the same format as Table 1 (refer to Figure 1).
TABLE 3: CARCINOGENICITY
In assessing the carcinogenic potential of a chemical, the Human
Health Assessment Group (HHAG) of EPA classifies the chemical into
one of the following groups, according to the weight of evidence
from epidemiolbgic and animal studies:
Group A - Human Carcinogen (sufficient evidence of carcino-
genicity in humans)
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Group B - Probable Human Carcinogen (Bl - limited evidence
of carcinogenicity in humans; B2 - sufficient
evidence of carcinogenicity in animals with
inadequate or lack of evidence in humans)
Group C - Possible Human Carcinogen (limited evidence of
carcinogenicity in animals and inadequate or lack
of human data)
Group D - Not Classifiable as to Human Carcinogenicity
(inadequate or no evidence)
Group E - Evidence of Noncarcinogenicity for Humans (no
evidence of carcinogenicity in adequate studies) .
These classifications are shown under [EPA Group] on Table 3.
Quantitative carcinogenic risk assessments are performed for
chemicals in Groups A and B, and on a case-by-case basis for
chemicals in Group C. Cancer [slope factors] (formerly called
cancer potency factors in the Superfund Public Health Evaluation
Manual) are estimated through the use of mathematical extrapolation
models, most commonly the linearized multistage model, for
estimating the largest possible linear slope (within the 95%
confidence limit) at low extrapolated doses that is consistent with
the data. The [slope factor] or risk is characterized as an upper-
bound estimate, i.e., the true risk to humans, while not identifi-
able, is not likely to exceed the upper-bound estimate and in fact
may be lower.
Quantitative carcinogenic estimates listed in Table 3 include
the following:
[slope factor] = risk per unit dose = risk per mg/kg/day
[unit risk] for inhalation exposure = risk per concentration
unit in air = risk per
[unit risk] for oral exposure = risk per concentration unit in
water = risk per
-30-
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[Unit risk] estimates for inhalation and oral exposure can be
calculated by dividing the appropriate [slope factor] by 70 kg and
multiplying by the inhalation rate (20 m3/day) or the water
consumption rate (2 £/day), respectively, for risk associated with
unit concentration in air or water. Hence,
risk per jig/m3 (air) = (risk per mg/kg/day) x 1 x 20 m3/day x 10"3(mg/jig)
70 kg
risk per jjg/C (water) = (risk per mg/kg/day) x 1 x 2 (!/day x 10"3 (rag/jig)
70 kg
Quantitative estimates of carcinogenic risk are listed under [Unit
Risk] or [Slope Factor] in Table 3. Information on the study and
data set used for estimation of the [slope factor] is given in the
other columns of Table 3.
In Table 3, the information listed is the following:
Chemical = Chemical Name/CASRN
Route = Route of Administration
Species = Tested Species
Experiment Length = Length of Exposure
Target = Target Organ(s) Affected at Critical
Level
Cancer = Tumors Observed at Critical Level
(Not Specified if More Than One Type
of Tumor)
[EPA Group] = EPA Classification by Weight of
Evidence
Oral [Slope Factor] = Risk Per Unit Dose
Inhalation [Slope Factor] = Risk Per Unit Dose
Oral [Unit Risk] = Risk Per Concentration Unit in Water
Inhalation [Unit Risk] = Risk Per Concentration Unit in Air
Reference = Reference Identification Number for
All Toxicity Values on the Same Line.
An example of this information is shown in Figure 2, HEAST Table 3:
Chemical = DIMETHYLHYDRAZINE, 1,2-/000077-78-1
Route = ORAL: DRINKING WATER
Species = MOUSE
Experiment Length = LIFETIME
Target = CARDIOVASCULAR SYSTEM
Cancer = TUMORS
-31-
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FIGURE 2
Example Data and References for Carcinogenicity
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
HEAST TABLE 3: CARCINOGENICITY
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)-'
January 1992
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)'1
DIMETHYLHYDRAZINE,1,2-
ORAL: DRINKING LIFETIME
WATER
MOUSE
000077-78-1
CARDIOVASCULAR
SYSTEM
TUMORS
82
3.7E+1
3.7E+1
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
1.1E-3
1.1E-2 009993
REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY
January 1992
DIMETHYLHYDRAZINE, 1,2- 000077-78-1
009993 TOTH B AND K PATEL. 1982. CARCINOGENICITY DOSE-RESPONSE STUDY BY CONTINUOUS ADMINISTRATION OF 1,2-DIMETHYLHYDRAZINE
DI-HYDROCHLORIDE IN MICE. I. LIGHT AND TRANSMISSION ELECTRON MICROSCOPIC STUDY OF COLONOIC NEOPLASMS. AM. J. OF PATH.
84:69-86.
US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
-------
[EPA Group] = B2
Oral [Slope Factor] = 3.7E+1 (MG/KG/DAY)-1
Inhalation [Slope Factor] = 3.7E+1 (MG/KG/DAY)-!
Oral [Unit Risk] = 1.1E-3 (UG/LJ-1
Inhalation [Unit Risk] = 1.1E-2 (UG/CU M)-l
Reference = 009993
Notice that the inhalation values for 1,2-Dimethylhydrazine was
extrapolated from the oral data.
Also given in Figure 2 is an example of the References for Table
3 for the same chemical. The reference is identified by the
chemical name (Dimethylhydrazine, 1,2-), the CASRN (000077-78-1),
and the reference number that links it with the toxicity values
(009993) .
Quantitative carcinogenic estimates are specific for the route
of. exposure for which they are listed on Table 3. Footnotes are
used to indicate those instances in which the values for inhalation
or oral exposure are based on extrapolation from another route of
exposure. The route-to-route conversion required to present
inhalation [slope factors] in the units of mg/kg/day is considered
by the CRAVE Work Group to be technically incorrect. It is
recommended that HEAST users who plan to use this information read
a further discussion of the difficulties inherent in this dose
conversion which can be found in Appendix A, Section II: Dose
Conversions On HEAST.
To estimate risk-specific concentrations in air from the [unit
risk] in air as presented in Table 3, the specified level of risk
is divided by the [unit risk] for air. Hence, the air concentra-
tion (in jitg/m3) corresponding to an upper-bound increased lifetime
cancer risk of IxlO"5 is calculated as follows:
-33-
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in air =
IxlO'5
[unit risk] in (jug/m)
3 "1
To estimate risk-specific concentrations in drinking water
from the oral [slope factor] values presented in Table 3, the
specified level of risk is multiplied by 70 kg and divided by the
[slope factor] times 2 £/day. Hence, the water concentration
corresponding to an upper-bound increased lifetime cancer risk of
IxlO"5 is calculated as follows:
mg/£ in water = _ IxlO'5 x 70 kg _
[slope factor] in (mg/kg/day) ~1 x 2 £/day
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USER'S GUIDE: RADIONUCLIDE CARCINOGENICITY
INTRODUCTION
EPA classifies all radionuclides as Group A carcinogens. HEAST
Tables 4A and 4B list ingestiori, inhalation and external exposure
cancer slope factors for radionuclides in units of picocuries and
becquerels, respectively.1 Ingestion and inhalation slope factors
are best estimates (i.e., median or 50th percentile values) of the
age-averaged, lifetime excess cancer incidence (fatal and nonfatal
cancer) risk per unit of activity inhaled or ingested, expressed as
risk/pCi or risk/Bq. External exposure slope factors are best
4
estimates of lifetime excess cancer incidence risk for each year of
exposure to external radiation from photon-emitting radionuclides
distributed uniformly in a thick layer of soil, and are expressed
as risk/yr per pCi (or Bq)/gram soil. When combined with site-
specific media concentration data and appropriate exposure
assumptions2, slope factors can be used to estimate lifetime cancer
risks to members of the general population due to radionuclide
exposures.
1 Slope factors are reported in Tables 4A and 4B in two different units of activity. Table 4A presents slope
factors in the customary units of picocuries (1 pCi = 10"12 curies (Ci) = 3.7xlO"2 nuclear transformations per
second) for consistency with the system used for radionuclides in the IRIS database; Table 4B presents slope
factors in the International System (SI) units of becquerels (1 Bq = 1 nuclear transformation per second;
approximately 27 pCi). Users can calculate cancer risks using slope factors expressed in either customary units
or SI units with equivalent results, provided that they also use air, water and soil concentration values in the same
system of units.
Agency standardized default exposure scenarios and assumptions for use in baseline risk assessment
are provided in EPA (1991), Risk Assessment Guidance for Superfund, Vol. I, Human Health Evaluation Manual,
Supplemental Guidance: "Standard Default Exposure Factors" (Interim Final), Office of Emergency and Remedial
Response, OSWER Directive 9285.6-03. [NTIS order number: PB 91-921314.]
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INTENDED USERS AND APPLICATIONS
HEAST users include individuals from the EPA, other Federal
agencies, States and contractors who are responsible for the
identification, characterization and remediation of sites contami-
nated with radioactive materials. Radionuclide slope factors are
calculated by EPA's Office of Radiation Programs (ORP) to assist
HEAST users with risk-related evaluations and decision-making at
various stages of the remediation process. During site assessment,
for example, slope factors are used in EPA's Hazard Ranking System
(HRS) to assign toxicity factor values to radionuclides to
calculate site scores. During the remedial investigation and
feasibility study (RI/FS), slope factors are used to determine
baseline site risk, to develop preliminary remediation goals, and
to evaluate cleanup alternatives. For further examples on the
application of radionuclide slope factors in risk evaluations,
users are referred to the following EPA documents:
• Hazard Ranking System (HRS), Federal Register (55 FR
515320), December 1990.
• Risk Assessment Guidance for Superfund; Volume I - Human
Health Evaluation Manual (RAGS/HHEM) , Part A, Baseline
Risk Assessment (EPA/540/1-89/002).
• RAGS/HHEM Part B, Development of Risk-Based Preliminary
Remediation Goals (OSWER Directive 9285.7-01B). [NTIS
order number: PB 92-963333.]
• RAGS/HHEM Part C, Risk Evaluation of Remedial Alternatives
(OSWER Directive 9285.7-01C). [NTIS order number: PB 92-
963334. ]
Copies of RAGS/HHEM Parts A, B and C are available to the public
from the National Technical Information Service (NTIS) at (703)
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487-4650. Copies are available to EPA staff by calling the
Superfund Documents Center at FTS 260-9760.
RADIATION EFFECTS
Ionizing radiation has been shown to be a carcinogen, a mutagen,
and a teratogen. At sufficiently high doses, radiation acts as a
complete carcinogen, serving as both an initiator and promoter, and
can induce cancers in nearly any tissue or organ in both humans and
animals. At lower doses and dose rates, radiation produces delayed
responses in the form of increased incidence of cancer long after
the exposure period. These delayed responses have been documented
extensively in epidemiological studies of Japanese atomic bomb
survivors, underground uranium miners, radium dial painters, and
patients subject to a variety of radiation treatments. Laboratory
animal research and mammalian tissue culture studies have provided
additional, collaborative data.
Mutagenic effects of radiation have been demonstrated primarily
in animal and tissue culture studies; limited data from studies of
A-bomb survivors indicate that humans may be as sensitive or less
sensitive than animals to radiogenic mutagenicity. Data are also
available from both human and animal studies on the teratogenic
effects of radiation. These data show that the fetus is most
sensitive to radiation injury during the early stages of organ
development (between 8 and 15 weeks for the human fetus).
Resultant radiation-induced malformations depend on which cells are
most actively differentiating at the time of exposure.
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EPA classifies all radionuclides as Group A carcinogens, based
on their property of emitting ionizing radiation and on the
extensive weight of evidence provided by epidemiological studies of
radiogenic cancers in humans. At Superfund radiation sites, EPA
generally evaluates potential human health risks based on the
radiotoxicity, i.e., adverse health effects caused by ionizing
radiation, rather than on the chemical toxicity, of each radionuc-
lide present. These evaluations consider the carcinogenic effects
of radionuclides only. In most cases, cancer risks are limiting,
exceeding both mutagenic and teratogenic risks.
DERIVATION OP RADIONUCLIDE SLOPE FACTORS
EPA's Office of Radiation Programs (ORP) calculates radionuclide
slope factor values using health effects data and dose and risk
models from a number of national and international scientific
advisory commissions and organizations, including the National
Academy of Sciences (NAS), the National Council on Radiation
Protection and Measurements (NCRP), the United Nations Scientific
Committee on the Effects of Atomic Radiation (UNSCEAR), and the
International Commission on Radiological Protection (ICRP). A
detailed discussion of ORP's approach and assumptions is provided
in Risk Assessment Methodology. Environmental Impact Statement,
NESHAPS for Radionuclides. Background Information Document - Volume
X (EPA 520/1-89-005: September 1989).
Radionuclide slope factors are calculated for each radionuclide
individually, based on its unique chemical, metabolic and radio-
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active properties. The calculation uses EPA's computer code
RADRISK3, life table analyses (described in EPA 520/1-89-005), and
cancer risk estimates based largely on the results of the NAS BEIR
III report.4 Ingestion and inhalation slope factors for radionu-
clides account for:
• the amount of radionuclide transported into the blood-
stream from either the gastrointestinal (GI) tract follow-
ing ingestion, or from the lungs following inhalation;
• the ingrowth and decay of radioactive progeny produced
within the body subsequent to intake;
• the distribution and retention of each radionuclide (and
its associated progeny, if appropriate) in body tissues
and organs;
• the radiation dose delivered to body tissues and organs
from the radionuclide (and its associated progeny, if
appropriate); and
• the sex, age, and organ-specific risk factors over the
lifetime of exposure.
The slope factors are the average risk per unit intake or
exposure for an individual in a stationary population with vital
statistics (mortality rates) of the United States in 1970. (The
expected lifetime for an individual in this population is about 70
years.) Consequently, radionuclide ingestion and inhalation slope
factors are not expressed as a function of body weight and time,
and do not require corrections for gastrointestinal absorption or
lung transfer efficiencies.
3 Dunning, D.E. Jr., Leggett, R.W., and Yalcinatas, M.G. (1980). "A Combined Methodology for Estimating
Dose Rates and Health Effects from Exposure to Radioactive Pollutants," ORNL/TM-7105.
4 National Academy of Sciences (1980). The Effects on Populations of Exposure to Low Levels of Ionizing
Radiation. Report of the Committee on the Biological Effects of Ionizing Radiation (BEIR III). National
Research Council, Washington, D.C. EPA anticipates that the slope factors for radionuclides in HEAST will
be modified in the future to incorporate the results of BEIR V (1990) and/or other relevant sources.
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NOTE: The GI absorption values (f,) . ICRP lung classifications
(D, w, Y) and radioactive half-lives are provided in HEAST
Tables 4A and 4B for reference only and should not be used to
correct, modify, or in any way adjust radionuclide slope factors
or intake assumptions in risk calculations.
External slope factors provide cancer risk estimates per unit
exposure to a uniform radionuclide concentration in soil. These
factors, which account for photon energy flux attenuation and
buildup in soil, are calculated for each radionuclide using volume
and surface dose factors derived using the computer code DFSOIL.5
Because of the radiation risk models employed for both
internal and external exposures, slope factors for radionuclides
are characterized as best estimates (i.e., median or 50th percen-
tile values) of the age-averaged lifetime total excess cancer
incidence risk per unit intake or exposure.
ABOUT THE INFORMATION PROVIDED IN TABLES 4A AND 4B:
Tables 4A and 4B list ingestion, inhalation and external
exposure slope factors of principal radionuclides, and provide key
parameter values used in the derivation of slope factor values. In
both tables, radionuclides are presented alphabetically by element
and atomic weight.
Selected radionuclides and radioactive decay chain products are
designated in the HEAST tables with the suffix "+D" (e.g., U-238+D,
Ra-226+D, Cs-137+D) to indicate that cancer risk estimates for
5 Sjoreen, A.L., Kocher, D.C., Killough, G.G. and Miller C.W. (1984). "MLSOIL and DFSOIL - Computer
Codes to Estimate Effective Ground Surface Concentrations for Dose Computations," Oak Ridge National
Laboratory, Oak Ridge, TN, ORNL-5974.
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these radionuclides include the contributions from their decay
products, assuming equal activity concentrations (i.e., secular
equilibrium) with the parent nuclide in the environment.6 Decay
chains are identified in Exhibit 1, and members of these chains are
noted in the HEAST tables with a dagger ("t").
In most cases, site-specific analytical data should be used to
establish the actual degree of equilibrium between each parent
radionuclide and its decay products in each media sampled.
However, in the absence of empirical data, the "+D" values for
radionuclides should be used unless there are compelling reasons
not to. For example, the external slope factors for Cs-137 and Cs-
137+D are 0.0 and 2xlO"6 (risk per year per pCi/gram) , respectively.
The value for Cs-137-t-D is higher because it includes the risk
contribution from cesium's short-lived gamma-emitting decay product
Ba-137m (half-life, 25.5 minutes) which, under most environmental
conditions, will be in secular equilibrium with Cs-137.
Note that there may be circumstances, such as long disposal
times or technologically enhanced concentrations of naturally
occurring radionuclides, that may necessitate the combination of
the risks of a parent radionuclide and its decay products over
several contiguous subchains. For example, Ra-226 soil analyses at
a site might show that all radium decay products are present in
secular equilibrium down to stable Pb-206 (See Exhibit 1) . In
6 There is one exception to the assumption of secular equilibrium: For the inhalation slope factor for Rn-
222+D reported in HEAST Tables 4A and 4B, ORP assumes a 50% equilibrium value for radon decay products
(Po-218, Pb-214, Bi-214 and Po-214) in air. ORP also used a slightly different risk model to calculate the
inhalation slope factor for Rn-222 + D based on human health risk estimates from recent epidemiological studies.
Consequently, users should not be concerned that the Rn-222+D inhalation slope factor in the HEAST tables
does not equal numerically the summation of individual inhalation factors for Rn-222 plus radon decay products.
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this case, Ra-226 risk calculations should be based on the
ingestion, inhalation and external exposure slope factors for the
Ra-226+D subchain, plus the ingestion, inhalation and external
exposure factors for the Pb-210+D subchain. For actual sites,
users should consult with a health physicist or radiochemist (1) to
evaluate the site-specific analytical data to determine the degree
of equilibrium between parent radionuclides and decay members of
contiguous decay chains and (2) to assist in the combination of
appropriate slope factor values. For health physics and radio-
analytical support, HEAST users may contact EPA's Regional
Radiation Program Managers, ORP's National Air and Radiation
Laboratory (NAREL) in Montgomery, Alabama, ORP's Las Vegas
Laboratory (ORP-LV) in Las Vegas, Nevada, or the ORP staff at EPA
Headquarters in Washington, D.C., listed in Exhibit 2.
A Chemical Abstract System Reference Number (CASRN) is assigned
to each radionuclide for identification and reporting accuracy
during risk assessments. Users should report a CASRN for all
radionuclides (both parent and decay product radionuclides)
included in risk calculations. Radioactive half-lives are provided
in the HEAST tables for reference.
The designations "D", "W", and "Y" presented under the heading
"ICRP Lung Class" in the tables refer to the lung clearance times
for inhaled particulate radionuclides, expressed as days (D), weeks
(W) , or years (Y), as recommended by the International Commission
on Radiological Protection (ICRP). Gaseous radionuclides, e.g.,
Rn-222, are designated with an asterisk ("*"). "GI Absorption
Factors, f," are the fractional amounts of each radionuclide that
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may be absorbed from the gastrointestinal (GI) tract into blood
following an oral intake. The ICRP lung clearance classifications
and GI absorption factors provided in Tables 4A and 4B are the
default values that EPA used to calculate radionuclide slope
factors for inhalation and ingestion exposures, respectively. These
factors are provided for reference only (see the Note Box on the
previous page).
WHERE TO ADDRESS QUESTIONS ABOUT RADIONUCLIDE SLOPE FACTORS
EPA continuously reviews the scientific literature on radiation
effects to ensure that the Agency's risk assessment methodologies
are consistent with current models and assumptions. As risk
assessment methodologies are refined, the slope factors in Tables
4A and 4B will be revised and updated.
HEAST users with questions about radionuclide slope factor
values and their use in radiation risk assessments should contact
the Remedial Guidance Section of the Radiation Assessment Branch of
ORP at (202) 260-9630 or FTS 260-9630. Written requests for
assistance can be sent by fax to (202) 260-6918 or FTS 260-6918.
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Exhibit 1: Radioactive Decay Chains Included in HEAST Tables 4A and 4B:
Principal Decay Chain
Uranium-238
Uranium-235
Thorium-232
Subchain3
U-238 + D
U-234
Th-230
Ra-226 + D
Pb-210 + D
Pb-206
U-235 + D
Pa-231
Ac-227 + D
Pb-207
Th-232
Ra-228 + D
Th-228 + D
Pb-208
Members'*
U-238
Th-234
Pa-234
U-234
Th-230
Ra-226
Rn-222tf
Po-218
Pb-214
Bi-214
Po-214
Pb-210
Bi-210
Po-210
Pb-206
U-235
Th-231
Pa-231
Ac-227
Th-227 [99%]
Ra-233
Rn-219
Po-215
Pb-211
Bi-211
Tl-207
Pb-207
Th-232
Ra-228
Ac-228
Th-228
Ra-224
Rn-220
Po-216
Pb-212
Bi-212
Po-212 [64%]
Tl-208 [36%]
Pb-208
Half-life0
4.468E + 09 Y
2.410E + 01 D
1.170E + OOM
2.445E + 05 Y
7.700E+04 Y
1.600E+03 Y
3.823E + OOD
3.050E + 00 M
2.680E + 01 M
1.990E + 01 M
1.637E-04 S
2.226E + 01 Y
5.013E + OOD
1.384E + 02 D
[Stable]
7.038E+08 Y
2.552E + 01 H
3.726E + 04 Y
2.177E + 01 Y
1.872E + 01 D
1.143E + 01 D
3.960E + OOS
1.778E-03 S
3.610E + 01 M
2.130E + 00 M
4.770E + 00 M
[Stable]
1.405E+10 Y
5.750E + 00 Y
6.130E + 00 H
1.913E + 00 Y
3.620E + 00 D
5.561E + 01 S
1.460E-01 S
1.064E + 01 H
6.055E + 01 M
2.980E-07 S
3.053E + 00 M
[Stable]
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Exhibit 1: Radioactive Decay Chains Included in HEAST Tables 4A and 4B
(Continued)*
Principal Decay Chain
Neptunium-237
Americium-243
Cesium-137
Strontium-90
Subchain51
Np-237 + D
U-233
Th-229 + D
Bi-209
Am-243 + D
Cs-137 + D
Sr-90 + D
Members'*
Np-237
Pa-233
U-233
Th-229
Ra-225
Ac-225
Fr-221
At-217
Bi-213
Po-213 [98%]
Tl-209 [2%]
Pd-209
Bi-209
Am-243
Np-239
Cs-137
Ba-137m
Sr-90
Y-90
Half-life0
2.140E + 06 Y
2.700E + 01 D
1.592E + 05 Y
7.340E + 03 Y
1.480E + 01 D
l.OOOE + 01 D
4.800E + 00 M
3.230E-02 S
4.565E + 01 M
4.200E-06 S
2.200E + 00 M
3.253E + OOH
[Stable]
7.380E + 03 Y
2.355E + OOD
3.017E + 01 Y
2.552E + OOM
2.860E + 01 Y
6.410E + 01H
* See the discussion on radioactive decay chains in the User's Guide.
a Radioactive decay chains included in HEAST Tables 4A and 4B. Radionuclides marked with the suffix
" + D" include risks from decay chain members, assuming secular equilibrium (i.e., equal activity concentra-
tions) in the environment.
The chain of decay products of a parent radionuclide extends to (but does not include) members of the
next subchain (e.g., U-238 + D includes U-238, Th-234 and Pa-234, but not U-234). Note that there may be
circumstances when it may be necessary to combine the risks for a parent radionuclide over several
contiguous subchains, depending on the conditions of equilibrium. Branches in the decay chain are
indicated in square brackets with branching percentages in parentheses.
tt A radon-222 decay subchain, Rn-222 + D, is also included in the HEAST tables, comprised of ingestion,
inhalation and external exposure slope factors for Rn-222 plus the corresponding slope factors for each of
its decay products (Po-218, Pb-214, Bi-214 and Po-214). For the ingestion and external exposure slope
factors for Rn-222 + D, decay products are assumed to be in secular equilibrium. For the inhalation slope
factor, decay products are assumed to be in 50% equilibrium.
0 Radioactive half-life in years (Y), days (D), hours (H), minutes (M) or seconds (S).
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Exhibit 2 EPA Radiation Program Staff
Tom D'Avanzo
Radiation Program Manager, Region 1
U.S. Environmental Protection Agency
John F. Kennedy Federal Building
Room 2311
Boston, MA 02203
Paul A. Giardina
Radiation Program Manager, Region 2
U.S. Environmental Protection Agency
Room 1005 (AWM-RAD)
26 Federal Plaza
New York, NY 10278
Lewis Felleisen
Radiation Program Manager, Region 3
Special Program Section (3AM12)
U.S. Environmental Protection Agency
841 Chestnut Street
Philadelphia, PA 19107
Chuck Wakamo
Radiation Program Manager, Region 4
U.S. Environmental Protection Agency
345 Courtland Street, ME
Atlanta, GA 30365
Gary V. Gulezian
Radiation Program Manager, Region 5
(5AR26)
U.S. Environmental Protection Agency
230 S. Dearborn Street
Chicago, IL 60604
Donna Ascenzi
Radiation Program Manger, Region 6
U.S. Environmental Protection Agency
Air Enforcement Branch (6T-E)
Air, Pesticides and Toxics Division
1445 Ross Avenue
Dallas, TX 75202-2733
Gale Wright
Radiation Program Manager, Region 7
U.S. Environmental Protection Agency
726 Minnesota Avenue
Kansas City, KS 66101
FTS: 835-4502
COMM: (617) 565-4502
FTS: 264-4110
COMM: (212) 264-4110
FTS: 597-8326
COMM: (215) 597-8326
FTS: 257-3907
COMM: (404) 347-3907
FTS: 886-6258
COMM: (312) 353-2206
FTS: 255-7223
COMM: (214) 655-7223
FTS: 276-7600
COMM: (913) 551-7600
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Exhibit 2. EPA Radiation Program Staff (Continued)
Milton W. Lammering FTS: 330-1709
Radiation Program Manager, Region 8 COMM: (303) 293-1713
(8HWM-RP)
U.S. Environmental Protection Agency
Suite 500
999 18th Street
Denver, CO 80202-2405
Michael S. Bandrowski FTS:484-1048
Radiation Program Manager, Region 9 COMM: (415) 744-1048
(AM)
U.S. Environmental Protection Agency
75 Hawthorne Street
San Francisco, CA 94105
Jerry Leitch FTS: 399-7660
Radiation Program Manager, Region 10 COMM: (206) 442-7660
(AT-082)
U.S. Environmental Protection Agency
1200 Sixth Avenue
Seattle, WA 98101
Samuel T. Windham, Director FTS: 228-3400
National Air and Radiation COMM: (205) 270-3400
Environmental Laboratory (NAREL)
Office of Radiation Programs
U.S. Environmental Protection Agency
1504 Avenue A
Montgomery, AL 36115-2601
Jed Harrison, Acting Director FTS: 545-2476
Office of Radiation Programs- COMM: (702) 798-2476
Las Vegas Facility (ORP/LVF)
U.S. Environmental Protection Agency
P.O. Box 98517
Las Vegas, NV 89193-8517
Robert S. Dyer, Chief FTS: 260-9630
Office of Radiation Programs - HQ COMM: (202) 260-9630
Radiation Assessment Branch
Radiation Studies Division (ANR-461)
U.S. Environmental Protection Agency
401 M Street, SW
Washington, DC 20480
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Exhibit 2. EPA Radiation Program Staff (Concluded)
Anthony B. Wolbarst, Chief FTS: 260-9630
Office of Radiation Programs - HQ COMM: (202) 260-9630
Remedial Guidance Section
Radiation Assessment Branch
Radiation Studies Division (ANR-461)
U.S. Environmental Protection Agency
401 M Street, SW
Washington, DC 20480
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIHENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD]
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
ACENAPHTHENE
NOAEL 175 MG/KG/DAY MOUSE
ORAL: GAVAGE 90 DAYS
000083-32-9
LIVER
HEPATOTOXICITY
6E-1
300
IRIS
ACENAPTHYLENE 000208-96-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ACEPHATE
LOAEL 2 PPM RAT
ORAL: DIET 13 WEEKS
030560-19-1
BRAIN
DECREASED CHOLINESTERASE
ACTIVITY
4E-3
30
REFERENCE
010165
005202
IRIS 005833
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
000067-64-1
ACETONE
NOEL 100 MG/ KG/0 AY RAT
ORAL: GAVAGE 90 DAYS
ACETONE CYANOHYDRIN
NOEL 10.8 MG CN/KG/DAY RAT
ORAL: DIET 104 WEEKS
LIVER
KIDNEY
KIDNEY
000075-86-5
WHOLE BODY
THYROID
CENTRAL
NERVOUS SYSTEM
INCREASED WEIGHT
INCREASED WEIGHT
NEPHROTOXICITY
ALTERED WEIGHT
EFFECTS
EFFECTS
1E+0
100
7E-2
500
IRIS 005204
7E-2 005776
500
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-1
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
Subchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfD] [RfC] [RfO] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mg/cu m) (mg/kg/day) (mg/cu m) (na/kg/day)
UF UF UF UF
ACETONITRILE 000075-05-8
NOAEL 100 PPM MOUSE 6E-2 IRIS 005210
INHALATION: 92 DAYS ERYTHROCYTES DECREASED CELL COUNT 300
INTERMITTENT
BLOOD DECREASED HEMATOCRIT
LIVER HEPATIC LESIONS
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5. UNDER REVIEW, CURRENT NUMBER SUBJECT TO
CHANGE.
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ACETOPHENONE 000098-86-2
NOAEL 10,000 PPM RAT 1E+0 IRIS 005212
ORAL: DIET 17 WEEKS NONE OBSERVED 300
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ACROLEIN 000107-02-8
LOAEL 0.917 MG/CU M
RAT NASAL EPITHELIUM RHINITIS 2E-4 IRIS 010429
INHALATION: 13 WEEKS NASAL EPITHELIUM NEUTROPHILIC INFILTRATION 100
NOAEL 15.6 MG/KG/DAY RAT 2E-1 2E-2 010390
ORAL: WATER 90 DAYS 100 1000
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ACRYLAMIDE 000079-06-1
NOEL 0.2 MG/KG/DAY RAT 2E-3 IRIS IRIS 005835
ORAL: DRINKING 90 DAYS NERVE DAMAGE 100
WATER
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (11/1/91) BY THE RfD/RfC WORKGROUP.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254. 1-2
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (cng/cu m) (mg/kg/day)
UF
UF
UF
UF
ACRYLIC ACID
LOAEL 5 PPM
INHALATION:
INTERMITTENT
HOUSE
13- WEEKS
NOAEL 83 MG/KG/DAY RAT
ORAL: DRINKING 3 MONTHS
WATER
000079-10-7
NASAL MUCOSA
WHOLE BODY
ORGANS, MAJOR
LESIONS
DECREASED WEIGHT
ALTERED WEIGHT
3E-3
100
ADIPONITRILE 000111-69-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ALACHLOR
NOEL 1 MG/KG/DAY DOG
ORAL: CAPSULE 1 YEAR
015972-60-8
BLOOD ANEMIA
SITES, MULTIPLE HEMOSIDEROSIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ALDICARB
LOAEL 0.02
MG/KG/DAY
ORAL: DIET
ALDRIN
LOAEL 0.025 MG/KG/DAY
ORAL: DIET
DOG
1 YEAR
RAT
2 YEARS
000116-06-3
BLOOD
000309-00-2
LIVER
CHOLINESTERASE INHIBITION
LESIONS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ALLIDOCHLOR 000093-71-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ALLYL ALCOHOL
NOEL 50 PPM
ORAL: DRINKING
WATER
000107-18-6
RAT
15 WEEKS
LIVER
KIDNEY
EFFECTS
EFFECTS
8E-1
100
1E-2
100
2E-4
100
3E-5
1000
5E-2
100
IRIS
IRIS
IRIS
IRIS
IRIS
IRIS
010346
005836
005157
005837
010433
005159
005838
005839
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-3
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Siixhronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(ms/cu m) (mg/kg/day) Cmg/cu m) (mg/kg/day)
UF UF UF UF
ALLYL CHLORIDE
NOAEL 17 MG/CU M
INHALATION:
INTERMITTENT
RABBIT
5 MONTHS
000107-18-6
NERVOUS SYSTEM NEUROTOXICITY
1E-2
300
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
ALUMINUM 007429-90-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ALUMINUM PHOSPHIDE
NOAEL 0.43 MG/KG/DAY
ORAL: DIET
AMETRYN
NOEL 10 MG/KG/DAY
ORAL: GAVAGE
020859-73-8
(0.51 MG/KG OF FOOD)
RAT
2 YEARS WHOLE BODY
UNSPECIFIED
RAT
13 WEEKS
000834-12-8
LIVER
ALTERED WEIGHT
ALTERED CLINICAL PARAMETERS
EFFECTS
AMINO-2-NAPHTHOL, 1- 002834-92-6
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
AMINO-2-NAPHTHOL HYDROCHLORIDE, 1- 001198-27-2
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
AMINOPHENOL, M-
NOAEL 1300 PPM RAT
ORAL: DIET 13 WEEKS
000591-27-5
WHOLE BODY
THYROID
ALTERED WEIGHT
ALTERED WEIGHT
AMINOPHENOL, 0- 000095-55-6
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
AMINOPHENOL, P- 000123-30-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
5E-3
300
4E-4
100
9E-2
100
7E-1
100
IRIS
5E-2
3000
010369
005162
IRIS 010255
IRIS 005841
005842
005843
7E-2 005844
1000
005845
005846
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-4
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mq/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
AMINOPYRIDINE, 4-
NOAEL 3 PPM RAT
ORAL: DIET 90 DAYS
000504-24-5
LIVER
BRAIN
INCREASED WEIGHT
INCREASED WEIGHT
2E-4
1000
2E-5
10000
005847
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
007664-41-7
HUMAN
AMMONIA
NOAEL 6.4 MG/CU M
NOAEL
INHALATION:
INTERMITTENT
34 MG/L
ORAL: DRINKING
WATER
HUMAN
NASAL CAVITY
LUNGS
LUNGS
SENSORY
RHINITIS
PNEUMONIA
LESIONS
TASTE THRESHOLD
1E-1
30
IRIS
34 mg/L
1
34 mg/L
1
010392
005166
SUBCHRONIC [RfD] COMMENT: GIVEN AS CONCENTRATION IN DRINKING WATER. SPECIFICALLY RELATED TO ORGANOLEPTIC THRESHOLD. SAFE CONCENTRATION MAY
BE HIGHER, BUT DATA ARE INADEQUATE TO ASSESS.
CHRONIC [RfD] COMMENT: UNDER REVIEW BY [RfD] WORK GROUP. GIVEN AS CONCENTRATION IN DRINKING WATER. SPECIFICALLY RELATED TO ORGANOLEPTIC
THRESHOLD. SAFE CONCENTRATION MAY BE HIGHER, BUT DATA ARE INADEQUATE TO ASSESS.
ANILINE
NOAEL 19 MG/CU M
INHALATION:
INTERMITTENT
NOAEL 19 MG/CU M
INHALATION:
INTERMITTENT
NOAEL 19 MG/CU M
INHALATION:
INTERMITTENT
000062-53-3
GUINEA PIG
20-26
WEEKS
RAT
20-26
WEEKS
MOUSE
20-26
WEEKS
SPLEEN
SPLEEN
SPLEEN
PATHOLOGY
PATHOLOGY
PATHOLOGY
1E-2
300
IRIS
010370
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-5
-------
CHEMICAL DOSE
LEVEL ROUTE
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfO] [RfC] [RfD]
(rng/cu m) (mg/kg/day) (mg/cu ro) (mg/kg/day)
UF UF UF UF
REFERENCE
ANTHRACENE
NOEL 1000 MG/KG/DAY MOUSE
ORAL: GAVAGE 90 DAYS
ANTIMONY (METALLIC)
LOAEL 0.35 MG SB/KG/DAY RAT
ORAL: DRINKING LIFETIME
WATER
ANTIMONY PENTOXIDE
LOAEL 0.46 MG/KG/DAY RAT
ORAL: DRINKING LIFETIME
WATER
000120-12-7
007440-36-0
WHOLE BODY
BLOOD
001314-60-9
WHOLE BODY
BLOOD
NONE OBSERVED
INCREASED MORTALITY
ALTERED CHEMISTRIES
INCREASED MORTALITY
ALTERED CHEMISTRIES
3E+0
300
4E-4
1000
5E-4
1000
IRIS
IRIS
5E-4
1000
010166
005170
005174
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
ANTIMONY POTASSIUM TARTRATE
LOAEL 0.91 MG/KG/DAY RAT
ORAL: DRINKING LIFETIME
WATER
000304-61-0
WHOLE BODY
BLOOD
INCREASED MORTALITY
ALTERED CHEMISTRIES
9E-4
1000
9E-4
1000
005234
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
ANTIMONY TETROXIDE
LOAEL
0.44 MG/KG/DAY
ORAL: DRINKING
WATER
RAT
LIFETIME
001332-81-6
WHOLE BODY
BLOOD
INCREASED MORTALITY
ALTERED CHEMISTRIES
4E-4
1000
4E-4
1000
005238
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
ANTIMONY TRIOXIDE
LOAEL 0.42 MG/KG/DAY
ORAL: DRINKING
WATER
RAT
LIFETIME
001309-64-4
WHOLE BODY -
BLOOD
INCREASED MORTALITY
ALTERED CHEMISTRIES
4E-4
1000
4E-4
1000
005242
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-6
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
SiiKhronic Chronic
[RfC] [RfO] [RfC] [RfO] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (cnq/kq/day)
UF UF UF UF
ARAMITE
NOAEL 100 PPM
ORAL: DIET
000140-57-8
NOAEL
RAT
104 WEEKS
LIVER INCREASED WEIGHT
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
500 PPM
ORAL: DIET
DOG
52 WEEKS
LIVER
DEGENERATION
1E-1
100
5E-2
100
005850
005849
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
007440-38-2
ARSENIC, INORGANIC
NOAEL 0.009 MG/L HUMAN
ORAL
SKIN
SKIN
KERATOSIS
HYPERPIGMENTATION
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ATRAZINE
NOEL 10 PPM
ORAL: DIET
001912-24-9
RAT
PUPS
DECREASED WEIGHT
3E-4
3
5E-3
100
IRIS
IRIS
010434
010435
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS DETERMINED FROM A TWO-GENERATION REPRODUCTION STUDY WITH EXPOSURES PRIOR TO MATING.
BARIUM
NOAEL 0.21 MG/KG/DAY
ORAL: WATER
007440-39-3
HUMAN
10 WEEKS
CARDIOVASCULAR
SYSTEM
INCREASED BLOOD PRESSURE
7E-2
3
IRIS
010348
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-7
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (na/kg/day) (cng/cu m) (mg/kg/day)
UF
UF
UF
UF
BARIUM CYANIDE
NOAEL 0.21 MG/KG/DAY HUMAN
ORAL: WATER
000542-62-1
CARDIOVASCULAR
SYSTEM
INCREASED BLOOD PRESSURE
1E-1
3
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (3/1/91). UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
BENEFIN 001861-40-1
NOAEL 25 MG/KG/DAY DOG
ORAL: DIET 1 YEAR ERYTHROCYTE DECREASED COUNT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
BENZAL CHLORIDE 000098-87-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
3E-1
100
BENZALDEHYDE
NOEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS
000100-52-7
KIDNEY
FORESTOMACH
EFFECTS
LESIONS
1E+0
100
BENZALDEHYDE CYANOHYDRIN 000532-28-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
BENZIDINE
LOAEL 2.7 MG/KG/DAY
ORAL: DRINKING
WATER
000092-87-5
MOUSE
33 MONTHS
BRAIN
LIVER
CELLULAR CHANGES
CELLULAR CHANGES
3E-3
1000
1E-1
3
IRIS
IRIS
IRIS
IRIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (7/1/91) BY THE RfD/RfC WORKGROUP.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
BENZOIC ACID
NOAEL 312 MG/DAY
ORAL: DIET
000065-85-0
HUMAN
NONE OBSERVED
4E+0
1
IRIS
010393
005852
005853
005854
005781
005830
005260
SUBCHRONIC [RfD] COMMENT: THE HUMAN DAILY PER CAPITA INTAKE WAS USED AS THE CRITICAL DOSE LEVEL. THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE
SUBCHRONIC [RfD].
CHRONIC [RfD] COMMENT: THE HUMAN DAILY PER CAPITA INTAKE WAS USED AS THE CRITICAL DOSE LEVEL.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-8
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY) January 1992
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu n) (ro/kg/day) (na/cu m) (na/kg/day)
UF UF UF UF
BENZYL ALCOHOL
NOAEL 143 MG/KG/DAY
000100-51-6
RAT
DECREASED WEIGHT
ORAL: GAVAGE 13 WEEKS WHOLE BODY
LOAEL 286 MG/KG/DAY
RAT
ORAL: GAVAGE 103 WEEKS FORESTOMACH EPITHELIAL HYPERPLASIA
1E+0
100
3E-1
1000
005856
005855
BERYLLIUM
NOAEL 0.54 MG/KG/DAY
ORAL: DRINKING
WATER
007440-41-7
RAT
LIFETIME
NONE OBSERVED
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENIC1TY.
BIPHENYL, 1,1'-
NOAEL 50 MG/KG/DAY
ORAL: DIET
000092-52-4
RAT
700 DAYS
KIDNEY
DAMAGE
5E-3
100
5E-2
1000
IRIS
005262
IRIS
IRIS
005857
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATAION [RfC] IS CONSIDERED NOT VERIFIABLE (11/1/90) BY THE RfD/RfC WORKGROUP.
BIS(Z-CHLOROISOPROPYL) ETHER
NOAEL 35.8 MG/KG/DAY MOUSE
ORAL: DIET 2 YEARS ERYTHROCYTES
039638-32-9
DECREASED HEMOGLOBIN
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGEN I CITY.
000117-81-7
4E-2
1000
IRIS
010257
BIS(2-ETHYLHEXYL)PHTHALATE
LOAEL 19 MG/KG/DAY
GUINEA PIG
ORAL: DIET 1 YEAR LIVER
INCREASED RELATIVE WEIGHT
2E-2
1000
IRIS
005612
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-9
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF
UF
UF
BISPHENOL A
LOAEL 50 MG/KG/DAY
000080-05-7
tlOAEL
BORON
LOAEL
ORAL
750 PPM
ORAL
4.5 MG/CU M
INHALATION:
INTERMITTENT
RAT
103 WEEKS
RAT
13 WEEKS
HUMAN
WHOLE BODY
WHOLE BODY
007440-42-8
RESPIRATORY
TRACT
BRONCHUS
DECREASED WEIGHT
DECREASED WEIGHT
IRRITATION
BRONCHITIS
UF
IRIS
6E-1
100
2E-2
100
2E-2
100
SUBCHRONIC [RfC] COMMENT: THE SUBCHRONIC [RfC] IS SPECIFICALLY FOR ANHYDROUS BORAX.
CHRONIC [RfC] COMMENT: THE CHRONIC [RfC] IS SPECIFICALLY FOR ANHYDROUS BORAX.
NOAEL
DOG
2 YEARS
8.8 MG/KG/DAY
ORAL: DIET 2 YEARS TESTIS LESIONS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
007637-07-2
KIDNEY NECROSIS
9E-2
100
IRIS
BORON TRIFLUORIDE
NOAEL 6 MG/CU M
INHALATION:
INTERMITTENT
RAT
13 WEEKS
7E-3
300
7E-4
3000
BROMINATED DIBENZO-P-DIOXINS
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
BROMINATED DIBENZOFURANS
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
BROMOACETONE 000598-31-2
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
BROMOCHLOROETHANES
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005268
005266
005269
005272
010395
005858
005859
005860
005861
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-10
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF
BROMODICHLOROMETHANE
LOAEL 17.9 MG/KG/DAY
000075-27-4
ORAL: GAVAGE
MOUSE
102 WEEKS
KIDNEY
CYTOMEGALY
UF
2E-2
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
BROMOFORM
NOEL 17.9 MG/KG/DAY
000075-25-2
RAT
13 WEEKS
BROMOMETHANE
LOAEL 26.6
ORAL: GAVAGE 13 WEEKS LIVER EFFECTS
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
000074-83-9
NERVOUS SYSTEM NEUROTOXICITY
2E-1
100
PPM
LOAEL
INHALATION:
INTERMITTENT
0.3 PPM
INHALATION:
INTERMITTENT
RABBIT
8 MONTHS
6E-2
300
RAT
29 MONTHS
NASAL CAVITY
LESIONS
NOAEL
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
1.4 MG/KG/DAY
RAT
ORAL: GAVAGE 13 WEEKS FORESTOMACH HYPERPLASIA
UF
UF
IRIS
005718
IRIS
005722
5E-3
100
005863
905863
1.4E-2
100
IRIS
BROMOPHENYL PHENYL ETHER,4- 000101-55-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005862
005864
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-11
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
BROMOPHOS 002104-96-3
NOAEL 5 MG/KG/DAY RAT
ORAL: DIET 3 GENERA- BLOOD
T10NS
LIVER
CRITICAL EFFECT
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
Sifcchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(cng/cu m) (mq/kg/day) (mg/cu m) (mg/kg/day)
UF
SUBCHRONIC [RfD] COMMENT: BASED ON A REPRODUCTION STUDY.
CHRONIC [RfD] COMMENT: BASED ON A REPRODUCTION STUDY.
BROMOXYNIL
NOEL 5 MG/KG/DAY
001689-84-5
RAT
2 YEARS
ORAL: DIET
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
BROMOXYNIL OCTANOATE 001689-99-2
NOEL 7.3 MG/KG/DAY
RAT
ORAL: DIET 2 YEARS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
BUSAN 77 031512-74-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
BUSAN 90 002491-38-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
BUTANOL, 1-
NOAEL 125 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS
000071-36-3
CENTRAL NERVOUS HYPOACTIVITY
SYSTEM
CENTRAL NERVOUS ATAXIA
SYSTEM
UF
5E-2
100
UF
2E-2
300
2E-2
300
1E+0
100
UF
5E-3
1000
005865
IRIS
005866
IRIS
005867
IRIS
005868
005869
005870
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-12
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu ro) (mg/kg/day)
UF
BUTYL BENZYL PHTHALATE, N-
NOAEL 159 MG/KG/DAY
RAT
ORAL: DIET 26 WEEKS
000085-68-7
LIVER ALTERED WEIGHT
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
002008-41-5
INCREASED RELATIVE WEIGHT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfO].
BUTYLATE
NOEL 5 MG/KG/DAY
ORAL: CAPSULE
DOG
12 MONTHS LIVER
UF
2E+0
100
5E-2
100
UF
UF
IRIS
IRIS
BUTYLCHLORIDE, t- 000507-20-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
BUTYROLACTONE, GAMMA- 000096-48-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CACODYLIC ACID
NOEL 9.2 MG/KG/DAY RAT
ORAL: DIET 90 DAYS
000075-60-5
NONE OBSERVED
3E-2
300
3E-3
3000
005616
005871
005810
005872
005873
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ARSENIC BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ARSENIC BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. UNDER REVIEW, CURRENT NUMBER
SUBJECT TO CHANGE.
CADMIUM
007440-43-9
IRIS
005280
CHRONIC [RfD] COMMENT: TWO SEPARATE REFERENCE DOSES VERIFIED FOR FOOD AND WATER.
SUBCHRONIC [RfD] COMMENT: BECAUSE OF BACKGROUND DIETARY EXPOSURE, AN ORAL SUBCHRONIC [RfD] WAS NOT ESTIMATED.
CHRONIC [RfC] COMMENT: UNDER REVIEW.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-13
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) lag/kg/day)
UF UF UF UF
CALCIUM CYANIDE
NOAEL 19.1 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000592-01-8
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYEL1N DEGENERATION
4E-2
500
IRIS
010258
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC ORAL [RfD]
WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CAPROLACTAM
000105-60-2
NOAEL 50 MG/KG/DAY
ORAL: DIET
CAPTAFOL
LOAEL 2 MG/KG/DAY
ORAL: CAPSULE
RAT
90 DAYS KIDNEY
002425-06-1
DOG
12 MONTHS KIDNEY
BLADDER
EFFECTS
EFFECTS
EFFECTS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CAPTAN
NOEL 12.5 MG/KG/DAY
ORAL: DIET
RAT
000133-06-2
WHOLE BODY
DECREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A MULTI-GENERATION REPRODUCTION STUDY.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CARBARYL
NOAEL 9.6 MG/KG/DAY
ORAL: DIET
000063-25-2
RAT
2 YEARS
KIDNEY
LIVER
TOXICITY
TOXICITY
5E-1
100
2E-3
1000
1.3E-1
100
1E-1
100
IRIS
IRIS
005284
005282
005874
IRIS
005875
IRIS
IRIS
005876
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (11/1/91) BY THE RfD/RfC WORKGROUP.
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-14
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu m) (TO/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
CARBOFURAN
NOEL 0.5 MG/KG/DAr DOG
ORAL: DIET 1 YEAR
001563-66-2
BLOOD
TESTIS
UTERUS
CHOLINESTERASE INHIBITION
EFFECTS
EFFECTS
5E-3
100
IRIS
005877
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000075-15-0
RABBIT
CARBON DISULFIDE
NOEL 11 MG/KG/DAY
INHALATION:
INTERMITTENT
FETUS
TOXICITY
1E-1
100
IRIS
010259
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS DETERMINED FROM A TERATOLOGY STUDY WITH EXPOSURES BEFORE AND DURING THE ENTIRE GESTATION
PERIOD. . • •
NOAEL
10 MG/CU M
INHALATION:
INTERMITTENT
RAT
GESTATION
010430
FETUS
TOXICITY
1E-2
1000
1E-2
1000
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
CARBON MONOXIDE 000630-08-0
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
CARBON TETRACHLORIDE
NOAEL 0.71 MG/KG/DAY
000056-23-5
RAT
12 WEEKS
ORAL: GAVAGE 12 WEEKS LIVER LESIONS
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
000075-87-6
LIVER
CHLORAL
LOAEL 15.7 MG/KG/DAY
ORAL: DRINKING
WATER
MOUSE
90 DAYS
EFFECTS
7E-3
100
2E-2
1000
IRIS
910430
005288
IRIS
005290
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-15
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
Cmg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
CHLORDANE
NOEL 0.055 MG/KG/DAY
ORAL: DIET
000057-74-9
RAT
130 WEEKS
LIVER
HYPERTROPHY
6E-5
1000
IRIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: UNDER REVIEW.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHLORINE CYANIDE
NOAEL 25.3 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000506-77-4
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
5E-2
500
IRIS
CHLORO-M-CRESOL, P-
NOAEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 28 DAYS
2E+0
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000059-50-7
WHOLE BODY DECREASED WEIGHT GAIN
CHLORO-1.3-BUTADIENE, 2- 000126-99-8
GENERAL COMMENT: SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHLOROACETALDEHYDE 000107-20-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHLOROACETIC ACID
LOAEL 30 MG/KG RAT
ORAL: GAVAGE 13 WEEKS
000079-11-8
HEART MYOCARDITIS
2E-2
1000
2E-3
10000
CHLOROANILINE, 2- 000095-51-2
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHLOROANILINE, 3- 000108-42-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005296
010261
005366
005342
005346
005347
005348
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-16
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
Subchronic Chronic
CHEH1CAL DOSE SPECIES [RfCD [RfD] [RfC] [RfD] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mg/cu m) (na/kg/day) (mg/cu m) (mg/kg/dav)
UF UF UF UF
CHLOROANILINE, 4- 000106-47-8
LOAEL 12.5 MG/KG/OAY
RAT SPLEEN PROLIFERATE LESIONS 4E-3 IRIS 005349
ORAL: DIET 78 WEEKS 3000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHLOROBENZENE 000108-90-7
NOAEL 19.5 MG/KG/DAY
DOG 2E-1 IRIS 005354
ORAL: CAPSULE 90 DAYS LIVER EFFECTS 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHLOROBENZILATE 000510-15-6
NOEL 5 MG/KG/DAY RABBIT 2E-2 IRIS 010260
ORAL: GAVAGE 13 DAYS GASTROINTES- DECREASED STOOL QUANTITY 300
TINAL SYSTEM
WHOLE BODY DECREASED FOOD CONSUMPTION
WHOLE BODY DECREASED WEIGHT GAIN
NERVOUS SYSTEM HYPERIRRITABILITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A TERATOLOGY STUDY WITH EXPOSURES DURING DAYS 7-19 OF GESTATION.
CHLOROBENZOIC ACID, P- 000074-11-3
NOAEL 26 MG/DAY RAT 2E+0 2E-1 005360
ORAL: DIET 5 MONTHS 100 1000
CHLOROBENZOTRIFLUORIDE, 4- 000098-56-6
NOAEL 15 MG/KG/DAY RAT 2E-1 2E-2 005364
ORAL: GAVAGE KIDNEY TUBULAR DEGENERATION 100 1000
SUBCHRONIC [RfD] COMMENT: BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES 4 WEEKS PRIOR TO MATING, DURING GESTATION, AND FOR 90
DAYS POST-WEANING.
CHRONIC [RfD] COMMENT: BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES 4 WEEKS PRIOR TO MATING, DURING GESTATION, AND FOR 90 DAYS
POST-WEAN ING.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254. 1-17
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF
UF
UF
UF
CHLOROBUTANE, 1-
NOAEL 43 MG/KG/DAY
ORAL: GAVAGE
000109-69-3
RAT
103 WEEKS
NOAEL
86 MG/KG/DAY
ORAL: GAVAGE
RAT
13 WEEKS
WHOLE BODY
CENTRAL
NERVOUS SYSTEM
BLOOD
CENTRAL
NERVOUS SYSTEM
WHOLE BODY
SPLEEN
000078-86-4
INCREASED MORTALITY
EFFECTS
HEMATOLOGIC EFFECTS
EFFECTS
DECREASED WEIGHT GAIN
HEMATOPOIESIS
4E-1
100
9E-1
100
CHLOROBUTANE, 2-
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHLOROCYCLOPENTADIENE 041851-50-7
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHLORODIBROMOMETHANE (See DIBROMOCHLOROMETHANE)
000067-66-3
CHLOROFORM
LOAEL 12.9 MG/KG/DAY
ORAL: CAPSULE
DOG
7.5 YEARS
LIVER
LESIONS
1E-2
1000
IRIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfC] COMMENT: UNDER REVIEW.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHLOROMETHANE 000074-87-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHRONIC [RfD] COMMENT: UNDER REVIEW.
CHRONIC [RfC] COMMENT: UNDER REVIEW.
GENERAL COMMENT: FORMERLY LISTED AS METHYL CHLORIDE..ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHLORONITROBENZENE, M- 000121-73-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005808
005806
005809
005297
005372
010005
005879
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-18
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIKENT LENGTH TARGET
CHLOROPHENOL, 2-
NOAEL 50 PPM
ORAL: DRINKING
WATER
RAT
000095-57-8
REPRODUCTION
CRITICAL EFFECT
REPRODUCTIVE EFFECTS
Subchronic Chronic
[RfC] [RfDl [RfC] [RfO] REFERENCE
(rng/cu m) (mg/kg/day) (mg/cu m) (mg/kg/dav)
UF UF UF UF
5E-2
100
IRIS
010436
SUBCHRONIC [RfO] COMMENT: BASED ON A REPRODUCTIVE STUDY WITH EXPOSURE 10 WEEKS PRIOR TO AND DURING MATING, GESTATION AND WEANING.
CHRONIC [RfD] COMMENT: BASED ON A REPRODUCTIVE STUDY WITH EXPOSURE 10 WEEKS PRIOR TO AND DURING MATING, GESTATION AND WEANING.
CHLOROPHENOL, 3- 000108-43-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHLOROPHENOL, 4- 000106-48-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHLOROPRENE (See CHLORO-1,3-BUTADIENE,2-
000075-29-6
CHLOROPROPANE, 2-
NOAEL 91.4 MG/KG/DAY
INHALATION:
INTERMITTENT
RAT
4 WEEKS
LIVER
EFFECTS
CHLOROPROPRENE,3- (See ALLYL CHLORIDE)
CHLOROTOLUENE, M- 000108-41-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHLOROTOLUENE, 0-
NOAEL 20 MG/KG/DAY RAT
ORAL: GAVAGE 103 DAYS
000095-49-8
WHOLE BODY DECREASED WEIGHT GAIN
CHLOROTOLUENE, P- 000106-43-4
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHLORPYRIFOS
NOEL 0.03 MG/KG/DAY
ORAL: CAPSULE
HUMAN
20 DAYS
OR 9 DAYS
002921-88-2
BLOOD
DECREASED CHOLINESTERASE
ACTIVITY
1E+0
100
1E-1
1000
2E-1
100
IRIS
3E-3
10
IRIS
005309
005310
010444
005880
010167
010200
005881
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-19
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (tng/kg/day) (mg/cu m) (mg/kg/day)
UF
UF
UF
UF
CHLORPYRIFOS METHYL 005598-13-0
NOAEL 1 MG/KG/DAY DOG
ORAL: DIET 2 YEARS LIVER
NOAEL 1 MG/KG/DAY
ORAL: DIET
RAT
3 GENERA-
TIONS
REPRODUCTION
EFFECTS
DECREASED FERTILITY
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
001897-45-6
CHLORTHALONIL
NOEL 1.5 MG/KG/DAY
ORAL: DIET
DOG
2 YEARS
KIDNEY
EFFECTS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHLORTHIOPHOS
NOAEL 0.08 MG/KG/DAY
ORAL: DIET
CHROMIUM (III)
NOEL 5 %
ORAL: DIET
RAT
2 YEARS
RAT
840 DAYS
060238-56-4
016065-83-1
NONE OBSERVED
1E-2
100
1.5E-2
100
8E-4
100
1E+0
1000
CHRONIC/SUBCHRONIC [RfC] COMMENT: INHALATION ISSUES ARE UNDER REVIEW BY THE RfD/RfC WORK GROUP
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHROMIUM (VI)
NOAEL 2.4 MG/KG/DAY
ORAL: DRINKING
WATER
018540-29-9
RAT
1 YEAR
NONE OBSERVED
2E-2
100
CHRONIC/SUBCHRONIC [RfC] COMMENT: INHALATION ISSUES ARE UNDER REVIEW BY THE RfD/RfC WORK GROUP
CHRYSENE 000218-01-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
1E-2
100
005882
IRIS
005883
8E-4
100
IRIS
005884
005731
IRIS
005522
005885
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-20
-------
CHEMICAL DOSE
LEVEL ROUTE
COPPER
LOAEL 5.3
ORAL
SPECIES
EXPERIMENT LENGTH TARGET
MG HUMAN
SINGLE
DOSE
007440-50-8
GASTROINTES-
TINAL SYSTEM
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY) January 1992
REFERENCE
CRITICAL EFFECT
IRRITATIOM
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO]
(mg/cu m) (cng/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
1.3 mg/l
1.3mg/l 005374
CHRONIC [RfD] COMMENT: CURRENT DRINKING WATER STANDARD OF 1.3 MG/L. DWCD (1987) CONCLUDED TOXICITY DATA WERE INADEQUATE FOR CALCULATION OF
AN [RfD] FOR COPPER.
SUBCHRONIC [RfD] COMMENT: CURRENT DRINKING WATER STANDARD OF 1.3 MG/L. DUCD (1987) CONCLUDED TOXICITY DATA WERE INADEQUATE FOR CALCULATION
OF AN [RfD] FOR COPPER.
COPPER CYANIDE
NOAEL 5 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
CRESOL, M-
NOAEL 50 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000544-92-3
LIVER
KIDNEY
WHOLE BODY
ORGANS
000108-39-4
WHOLE BODY
NERVOUS SYSTEM
HISTOPATHOLOGY
HISTOPATHOLOGY
DECREASED WEIGHT
DECREASED WEIGHT
DECREASED WEIGHT GAIN
NEUROTOXICITY
5E-2
100
IRIS
010262
5E-1
100
IRIS
005380
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENIC!TY.
CRESOL, 0-
NOAEL 50 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000095-48-7
WHOLE BODY
NERVOUS SYSTEM
DECREASED WEIGHT GAIN
NEUROTOXICITY
5E-1
100
IRIS
005384
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGEN I CITY.
CRESOL, P-
NOAEL 50 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000106-44-5
WHOLE BODY
NERVOUS SYSTEM
DECREASED WEIGHT GAIN
NEUROTOXICITY
5E-1
100
5E-2
1000
005388
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (8/1/91). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-21
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfCJ [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu ro) (mg/kg/day)
UF
UF
UF
UF
CUMENE
NOAEL 105.1
PPM
INHALATION:
INTERMITTENT
RAT
4 WEEKS
000098-82-8
INVOLVEMENT
IRRITATION
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
CENTRAL
NERVOUS SYSTEM
NOSE
9E-2
1000
NOAEL
154 MG/KG/DAY
ORAL: GAVAGE
CYANAZINE
NOEL 0.625 MG/KG/DAY
ORAL: DIET
RAT
194 DAYS
DOG
1 YEAR
KIDNEY
INCREASED WEIGHT
021725-46-2
WHOLE BODY DECREASED WEIGHT GAIN
BLOOD INCREASED PLATELET COUNT
BLOOD ALTERED CLINICAL CHEMISTRY
PARAMETERS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000057-12-5
CYANIDE (CN-)
NOAEL 10.8 MG/KG/DAY RAT
ORAL: DIET
104 WEEKS
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000460-19-5
CYANOGEN
NOAEL 21.6 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
4E-1
300
2E-3
300
2E-2
500
4E-2
500
9E-3
10000
005908
IRIS
IRIS
005392
010411
IRIS
005396
IRIS
010263
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC ORAL [RfD]
WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-22
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY) January 1992
Subchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfO] [RfC] [RfO] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mg/cu m) (mq/kq/day) (mg/cu m) (mg/kg/day)
UF (If UF UF
CYANOGEN BROMIDE 000506-68-3
NOAEL 44 MG/KG/DAY RAT 9E-2 IRIS 010264
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT 500
THYROID EFFECTS
NERVE MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC ORAL [RfD]
WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CYCLOATE 001134-23-2
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005886
CHRONIC [RfO] COMMENT: UNDER REVIEW.
CYCLOHEXANOL 000108-93-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005887
CYCLOHEXYLAMINE 000108-91-8
IRIS 005400
NOAEL 30 MG/KG/DAY RAT 3E-1 005398
ORAL: DIET 90 DAYS WHOLE BODY DECREASED WEIGHT GAIN 100
TEST IS DECREASED WEIGHT
CYCLOPENTADIENE 000542-92-7
GENERAL COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
DACTHAL 001861-32-1
NOEL 50 MG/KG/DAY RAT 5E-1 IRIS 005888
ORAL: DIET 2 YEARS KIDNEY INCREASED WEIGHT 100
ADRENAL INCREASED RELATIVE WEIGHT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254. 1-23
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfO] [RfC] [RfO] REFERENCE
(mg/cu ro) (mg/lcg/day) (mg/cti ro) (mg/kg/day)
UF UF UF UF
DALAPON
NOEL 8.45 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000075-99-0
KIDNEY INCREASED RELATIVE UEIGHT
3E-2
300
IRIS
005889
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO DALAPON SODIUM BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC ORAL [RfD]
WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO DALAPON SODIUM BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
DB,2,4- (See DICHLOROPHENOXY)BUTYRIC ACID,4(2,4-)
000050-29-3
DDT
NOEL
0.05 MG/KG/DAY
ORAL: DIET
RAT
27 WEEKS
LIVER
LESIONS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DECABROMODIPHENYL ETHER
NOEL 1 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
001163-19-5
LIVER
INCREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DIAZINON
NOAEL 0.09 MG/KG/DAY
ORAL: DIET
000333-41-5
RAT
35-42 DAYS BLOOD
DECREASED CHOLINESTERASE
ACTIVITY
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
DIBENZOFURAN 000132-64-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DIBROMOBENZENE, 1,4-
NOAEL 10 MG/KG/DAY RAT
ORAL: GAVAGE 45 OR 90
DAYS
000106-37-6
LIVER
LIVER
INCREASED RELATIVE WEIGHT
ALTERED ENZYME ACTIVITIES
5E-4
100
1E-2
100
9E-4
100
1E-1
100
IRIS
005408
IRIS
005891
9E-4 005892
100
IRIS
005409
005893
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-24
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY) January 1992
Subchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfO] [RfC] [RfO] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mg/cu m) (mg/kg/day) (na/cu m) (mg/kg/day)
UF UF UF UF
DIBROMOCHLOROMETHANE 000124-48-1
NOEL 21.4 MG/KG/DAY
RAT 2E-1 IRIS 005894
ORAL: GAVAGE 13 WEEKS LIVER LESIONS 100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DIBUTYL PHTHALATE 000084-74-2
NOAEL 125 MG/KG/DAY RAT 1E+0 IRIS IRIS 005622
ORAL: DIET 52 WEEKS WHOLE BODY INCREASED MORTALITY 100
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (10/1/90) BY THE RfD/RfC WORKGROUP.
DICHLOROBENZENE, 1,2- 000095-50-1
NOAEL 89 MG/KG/DAY RAT 9E-1 IRIS 005828
ORAL: GAVAGE 13 WEEKS LIVER EFFECTS 100
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
DICHLOROBENZENE, 1,3- 000541-73-1
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005414
DICHLOROBENZENE, 1,4- 000106-46-7
NOAEL 454.6 MG/CU M RAT 7E-1 7E-1 005787
INHALATION: 76 WEEKS LIVER EFFECTS 100 100
INTERMITTENT
KIDNEY EFFECTS
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DICHLOROBUTENES
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005415
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254. 1-25
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
DICHLORODIFLUOROMETHANE
NOAEL 90 MG/KG/DAY DOG
ORAL: DIET 90 DAYS
000075-71-8
NONE OBSERVED
9E-1
100
IRIS
005496
005498
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
DICHLOROETHANE, 1,1-
NOEL 115 MG/KG/DAY
000075-34-3
INHALATION:
INTERMITTENT
RAT
13 WEEKS
NONE OBSERVED
1E+0
100
1E-1
1000
005790
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DICHLOROETHYLENE, 1,1-
LOAEL 9 MG/KG/DAY
RAT
ORAL: DRINKING 2 YEARS
WATER
000075-35-4
LIVER
LESIONS
9E-3
1000
IRIS
005419
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DICHLOROETHYLENE, 1,2-C-
NOAEL 32 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000156-59-2
BLOOD
BLOOD
DECREASED HEMATOCRIT
DECREASED HEMOGLOBIN
1E-1
300
1E-2
3000
005420
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-26
-------
CHEMICAL DOSE
LEVEL ROUTE
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
REFERENCE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD]
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
DICHLOROETHYLENE, 1,2-T-
NOAEL 17 MG/KG/DAY
HOUSE
ORAL: DRINKING 90 DAYS
WATER
000156-60-5
BLOOD
INCREASED ALKALINE
PHOSPHATASE
2E-1
100
IRIS
DICHLOROPHENOL, 2,3- 000576-24-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DICHLOROPHENOL, 2,4- 000120-83-2
NOEL 3 PPM RAT
ORAL: DRINKING 2 GENERA- IMMUNE SYSTEM
WATER TIONS
ALTERED IMMUNE FUNCTION
3E-3
100
IRIS
005895
005315
005314
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES BEFORE AND DURING GESTATION, PARTURITION, AND WEANING OF
PUPS.
DICHLOROPHENOL, 2,5- 000583-78-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DICHLOROPHENOL, 2,6- 000087-65-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DICHLOROPHENOL, 3,4- 000095-77-2
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DICHLOROPHENOL, 3,5- 000591-35-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DICHLOROPHENOXY ACETIC ACID, 2,4-
NOAEL 1 MG/KG/DAY RAT
ORAL: DIET 91 DAYS BLOOD TOXICITY
LIVER TOXICITY
KIDNEY TOXICITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000094-75-7
1E-2
100
IRIS
005316
005317
005318
005319
010265
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254. FTS 684-7254.
1-27
-------
CHEMICAL DOSE
LEVEL ROUTE
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN I CITY) January 1992
REFERENCE
SPECIES
EXPERIHENT LENGTH TARGET
DICHLOROPHENOXY)BUTYRIC ACID, 4-(2,4-
NOAEL 8 MG/KG/OAY DOG
ORAL: DIET 90 DAYS CARDIOVASCULAR
SYSTEM
WHOLE BODY
GENERAL COMMENT: FORMERLY LISTED AS 2.4-DB.
DICHLOROPROPANE, 1,1- 000078-99-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CRITICAL EFFECT
000094-82-6
HEMORRHAGE
INCREASED MORTALITY
DICHLOROPROPANE, 1,2-
NOAEL 69.3 MG/CU M RAT
INHALATION: 13 WEEKS
INTERMITTENT
000078-87-5
NASAL MUCOSA HYPERPLASIA
DICHLOROPROPANE, 1,3- 000142-28-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DICHLOROPROPANE, 2,2- 000594-20-7
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DICHLOROPROPENE, 1,3-
NOAEL 5 PPM MOUSE
INHALATION: 2 YEARS
INTERMITTENT
000542-75-6
NASAL MUCOSA
NASAL MUCOSA
HYPERTROPHY
HYPERPLASIA
Subchronic • Chronic
[RfC] [RfDJ [RfC] [RfD]
(mg/cu m) (ing/kg/day) (mg/cu m) (mg/kg/day)
UF
UF
8E-2
100
UF
1.3E-2
100
IRIS
2E-2
30
IRIS
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
NOEL
3 MG/KG/DAY RAT
ORAL: DIET 90 DAYS ORGANS INCREASED WEIGHT
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DICHLORPROP 000120-36-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHRONIC [RfD] COMMENT: UNDER REVIEW.
3E-3
1000
UF
IRIS
IRIS
005890
005897
005898
005899
005900
010351
005901
005896
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-28
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (tng/kg/day)
UF UF UF UF
DICYCLOPENTADIENE
NOEL 32 MG/KG/DAY
ORAL:-DIET
000077-73-6
RAT
3 GENERA-
TIONS
NONE OBSERVED
3E-1
100
3E-2
1000
005425
SUBCHRONIC [RfD] COMMENT: BASED ON A 3-GENERATION REPRODUCTION STUDY.
CHRONIC [RfD] COMMENT: BASED ON A 3-GENERATION REPRODUCTION STUDY.
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
DIELDRIN
NOAEL 0.005 MG/KG/DAY
ORAL: DIET
RAT
2 YEARS
000060-57-1
LIVER
LESIONS
5E-5
100
IRIS 005429
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DIETHYL PHTHALATE
NOAEL 750 MG/KG/DAY
ORAL: DIET
000084-66-2
RAT
16 WEEKS WHOLE BODY
ORGANS
DECREASED GROWTH
DECREASED WEIGHT
000311-45-5
8E+0
100
IRIS 005620
DIETHYL-P-NITROPHENYL PHOSPHATE
(PARAOXON)
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DIETHYLANILINE, N,N- 000091-66-7
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DIETHYLENE GLYCOL MONOBUTYL ETHER 000112-34-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005922
005903
005482
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-29
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
SiAchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(na/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF
UF
UF
UF
DIETHYLENE GLYCOL MONOETHYL ETHER
NOEL 200 MG/KG/DAY RAT
ORAL: DRINKING KIDNEY
WATER
CHRONIC [RfD] COMMENT: BASED ON A 3-GENERATION REPRODUCTION STUDY.
000111-90-0
HISTOPATHOLOGY
NOEL
500 MG/KG/DAY
ORAL: DIET
RAT
90 DAYS
DIETHYLFORMAMIDE
NOEL 0.546 MG//DAY, 5 DAYS/WEEK
RAT
ORAL: GAVAGE 73 WEEKS
KIDNEY
TEST IS
000617-84-5
IMPAIRED FUNCTION
INCREASED WEIGHT
NONE OBSERVED
DIETHYLHYDRAZINE, 1,2- 001615-80-1
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DIMETHOATE
NOEL 0.05 MG/KG/DAY
ORAL: DIET
RAT
2 YEARS
000060-51-5
BRAIN
DECREASED CHOLINESTERASE
ACTIVITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000131-11-3
DIMETHYL PHTHALATE
NOEL 1000 MG/KG/DAY
ORAL: DIET
RAT
2 YEARS
KIDNEY
EFFECTS
5E+0
100
1.1E-2
100
2E-4
300
1E+1
100
2E+0
100
1.1E-2
100
IRIS
IRIS
1E-H
100
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (10/1/90) BY THE RfD/RfC WORKGROUP.
DIMETHYLANILINE, N,N- 000121-69-7
LOAEL 22.32 MG/KG/DAY
MOUSE
ORAL: GAVAGE 13 WEEKS SPLEEN
EFFECTS
2E-2
1000
IRIS
005478
005476
010437
005921
005923
010267
005924
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-30
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIHENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (ing/kg/day)
UF UF UF UF
DIMETHYLFORMAMIDE, N,N-
NOAEL 96 MG/KG/DAY
RAT
119 DAYS
ORAL: DIET
000068-12-2
LIVER
EFFECTS
1E+0
100
1E-1
1000
LOAEL
3E-2
300
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
22 MG/CU M HUMAN
INHALATION:
INTERMITTENT
LIVER
GASTROINTES-
TINAL SYSTEM
EFFECTS
EFFECTS
IRIS
DIMETHYLPHENOL, 2,3-
000526-75-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
000105-67-9
DIMETHYLPHENOL, 2,4-
NOAEL 50 MG/KG/DAY MOUSE
ORAL: GAVAGE 90 DAYS
NERVOUS SYSTEM
BLOOD
EFFECTS
ALTERATIONS
2E-1
300
DIMETHYLPHENOL, 2,5- 000095-87-4
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DIMETHYLPHENOL, 2,6-
NOEL 0.6 MG/KG/DAY RAT
ORAL 8 MONTHS
DIMETHYLPHENOL, 3,4-
NOEL 1.4 MG/KG/DAY RAT
ORAL 8 MONTHS
DIMETHYLTEREPHTHALATE
LOAEL 125 MG/KG/DAY
RAT
ORAL: DIET 103 WEEKS
000576-26-1
WHOLE BODY
ORGANS, MAJOR
000095-65-8
WHOLE BODY
ORGANS, MAJOR
CARDIOVASCULAR
SYSTEM
000120-61-6
INCREASED WEIGHT
LESIONS
DECREASED WEIGHT
LESIONS
ALTERED BLOOD PRESSURE
6E-3
100
1E-2
100
KIDNEY
INFLAMMATION
1E-1
1000
IRIS
IRIS
IRIS
IRIS
005925
010352
005926
010266
005928
005431
005437
005930
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-31
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfO] REFERENCE
(mg/cu m) (na/lcg/day) (na/cu m) (ma/kg/day)
UF UF UF UF
DIMETHYLUREA, N,N- 000598-94-7
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DI-N-OCTYL PHTHALATE
LOAEL 175 MG/KG/DAY RAT
ORAL: DIET 7-12
MONTHS
000117-84-0
KIDNEY
LIVER
LIVER
LIVER
INCREASED WEIGHT
INCREASED WEIGHT
INCREASED SCOT ACTIVITY
INCREASED SGPT ACTIVITY
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
DINITRO-0-CRESOL, 4,6- 000534-52-1
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINITRO-P-CRESOL, 2,6- 000609-93-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINITROBENZENE, 1,2- 000528-29-0
(o-DINITROBENZENE) 000528-29-0
NOAEL 0.4 MG/KG/DAY RAT
ORAL: DRINKING 16 WEEKS SPLEEN
WATER
INCREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: DERIVED BY ANALOGY TO 1,3-DINITROBENZENE.
CHRONIC [RfD] COMMENT: DERIVED BY ANALOGY TO 1,3-DINITROBENZENE.
DINITROBENZENE, 1,3-
(m-DINITROBENZENE)
NOAEL 0.4 MG/KG/DAY RAT
ORAL: DRINKING
WATER
000099-65-0
SPLEEN
INCREASED WEIGHT
2E-2
1000
2E-2
1000
4E-3
100
4E-4
1000
005931
010275
008883
005934
010201
1E-3
100
IRIS
008884
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-32
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchconic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu a) (mg/kq/day)
UF
UF
UF
UF
DINITROBENZENE, 1,4- 000100-25-4
(p-DINITROBENZENE)
NOAEL 0.4 MG/KG/OAY RAT
ORAL: DRINKING 16 WEEKS SPLEEN
WATER
INCREASED WEIGHT
4E-3
100
4E-4
1000
SUBCHRONIC [RfD] COMMENT: DERIVED BY ANALOGY TO 1,3-DINITROBENZENE.
CHRONIC [RfD] COMMENT: DERIVED BY ANALOGY TO 1,3-DINITROBENZENE.
DINITROPHENOL, 2,3- 000066-56-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINITROPHENOL, 2,4-
LOAEL 2 MG/KG/DAY HUMAN
ORAL
000051-28-5
EYE
CATARACT
2E-3
1000
IRIS
IRIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC [RfD] WAS ADOPTED AS THE SUBCHRONIC [RfD].
CHRONIC [RfD] COMMENT: BASED ON A THERAPEUTIC DOSE.
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (10/1/91) BY THE RfD/RfC WORKGROUP.
DINITROPHENOL, 2,5- 000329-71-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINITROPHENOL, 2,6- 000573-56-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINITROPHENOL, 3,5- 000586-11-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINITROTOLUENE, 2,3- 000602-01-7
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINITROTOLUENE, 2,4-
000121-14-2
IRIS
CHRONIC [RfD] COMMENT: UNDER REVIEW.
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (3/1/91) BY THE RfD/RfC WORKGROUP.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
010202
005936
010438
005937
005938
005939
005940
005941
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-33
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu m) (mg/kg/day) (ma/cu m) (mg/kg/day)
UF UF UF UF
DINITROTOLUENE, 2,5- 000619-15-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINITROTOLUENE, 2,6- 000606-20-2
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
CHRONIC [RfD] COMMENT: UNDER REVIEW.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DINITROTOLUENE, 3,4- 000610-39-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DINOSEB
LOAEL 1 MG/KG/DAY RAT
ORAL: DIET 29 WEEKS
000088-85-7
FETUS
DECREASED WEIGHT
1E-3
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS DETERMINED FROM A 3-GENERATION REPRODUCTION STUDY.
DIPHENYLAMINE,N,N-
NOEL 2.5 MG/KG/DAY
.ORAL: DIET
DOG
2 YEARS
000122-39-4
WHOLE BODY
LIVER
KIDNEY
DECREASED WEIGHT GAIN
INCREASED WEIGHT
INCREASED WEIGHT
2.5E-2
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
DIRECT LIGHTFAST BLUE 004399-55-7
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
DISULFOTON
LOAEL 0.04 MG/KG/DAY
ORAL: DIET
000298-04-4
RAT
2 YEARS
EYE
BLOOD
DEGENERATION
CHOLINESTERASE INHIBITION
4E-5
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS
IRIS
IRIS
005942
005943
005944
005945
005946
005947
010412
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-34
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
ENDOSULFAN
LOAEL 0.15 MG/KG/DAY
ORAL: DIET
000115-29-7
RAT
2 GENERA- KIDNEY
TIONS
LESIONS
5E-5
3000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A 2-GENERATION REPRODUCTION STUDY.
ENDOTHALL
NOEL 2 MG/KG/DAY
ORAL: DIET
000145-73-3
DOG
2 YEARS
STOMACH INCREASED WEIGHT
SMALL INTESTINE INCREASED WEIGHT
2E-2
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000072-20-8
ENDRIN
NOEL 0.025 MG/KG/DAY
ORAL: DIET
DOG
2 YEARS
CENTRAL CONVULSIONS
NERVOUS SYSTEM
LIVER LESIONS
3E-4
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS
010439
IRIS
005948
IRIS
005445
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-35
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
Subchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfD] [RfC] IRfO] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mg/cu m) (mg/kg/day) (ro/cu •) Caa/kg/day)
UF UF UF UF
EPICHLOROHYDRIN 000106-89-8
NOEL 0.25 MG/CU M MOUSE 3E-3 005950
INHALATION: 87-88 DAYS NASAL TURBINATE INJURY 100
INTERMITTENT
NOAEL 0.5 PPM RAT 1E-3 905950
INHALATION: 90 DAYS NASAL EPITHELIUM LESIONS 300
INTERMITTENT
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
LOAEL 37.8 MG/CU M
RAT 2E-3 IRIS 010440
INHALATION: 136 WEEKS KIDNEY LESIONS 1000
INTERMITTENT
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE-TO-ROUTE EXTRAPOLATION. THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON ROUTE-TO-ROUTE EXTRAPOLATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
EPIC 000759-94-4
NOEL 2.5 MG/KG/DAY
RAT 2.5E-2 ' IRIS 005959
ORAL: DIET 2 GENERA- HEART DEGENERATIVE CARDIOMYOPATHY 100
TIONS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS DETERMINED FROM A 2-GENERATION REPRODUCTION STUDY.
ETHOPROP 013194-48-4
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005951
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254. 1-36
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
ETHOXYETHANOL, 2-
NOAEL 380 MG/CU M
INHALATION:
INTERMITTENT
000110-80-5
LOAEL
NOEL
357 MG/KG/DAY
ORAL: GAVAGE
50 UL/KG/DAY
ORAL: GAVAGE
RABBIT
13 WEEKS
RAT
103 WEEKS
RAT
21 DAYS
BLOOD
WHOLE BODY
FETUS
ALTERED HEMATOLOGY
DECREASED WEIGHT
SKELETAL MALFORMATIONS
UF
2E+0
30
UF
UF
IRIS
UF
4E-1
1000
5E-1
100
010441
005470
00546S
SUBCHRONIC [RfD] COMMENT: BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS 1-21 OF GESTATION.
ETHOXYETHANOL ACETATE, 2- 000111-15-9
CHRONIC [RfC] COMMENT: UNDER REVIEW.
SUBCHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ETHOXYETHYL ACRYLATE, 2- 000106-74-1
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ETHOXYETHANOL DODECANOATE, 2- 000106-13-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ETHOXYETHANOL PHOSPHATED, 2- 068554-00-7
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ETHOXYETHYL METHACRYLATE, 2- 002370-63-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ETHYL ACETATE
NOEL 900 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000141-78-6
WHOLE BODY
WHOLE BODY
INCREASED MORTALITY
DECREASED WEIGHT
9E+0
100
IRIS
005953
005956
005955
005954
005957
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-37
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
Subchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfD] [RfC] [RfO] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mg/cu m) (mg/kg/dav) (mg/cu ro) (ma/kg/day)
UF UF UF UF
ETHYLBENZENE 000100-41-4
NOAEL 434 HG/CU M 1E+0 IRIS 005446
300
RABBIT
INHALATION: 24 DAYS FETUS DEVELOPMENTAL TOXICITY
INTERMITTENT
RAT
INHALATION: 19 DAYS FETUS DEVELOPMENTAL TOXICITY
INTERMITTENT
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
CHRONIC [RfC] COMMENT: BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURE DURING GESTATIONAL DAYS 1-19 (RAT) OR 1-24 (RABBIT).
NOEL 97.1 MG/KG/DAY
RAT 1E+0 IRIS 005447
ORAL: GAVAGE 182 DAYS LIVER HEPATOTOXICITY 100
KIDNEY NEPHROTOXICITY
ETHYL CHLORIDE 000075-00-3
NOAEL 1504 PPM MOUSE 1E+1 IRIS 010371
INHALATION: 10 DAYS FETUS DELAYED OSSIFICATION 300
INTERMITTENT
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
CHRONIC [RfD] COMMENT: BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
ETHYL DIPROPYLTHIOCARBAMATE,2- (See EPTC)
ETHYL ETHER 000060-29-7
NOAEL 500 MG/KG/DAY RAT 2E+0 IRIS 010396
ORAL: GAVAGE 13 WEEKS WHOLE BODY DECREASED WEIGHT 300
ETHYL METHACRYLATE 000097-63-2
NOEL 7.5 MG/KG/DAY RAT 9E-2 9E-2 005961
ORAL: DRINKING 2 YEARS KIDNEY INCREASED RELATIVE WEIGHT 100 100
WATER
CHRONIC [RfD] COMMENT: CALCULATED FROM METHYL METHACRYLATE DATA BY MULTIPLYING BY THE RATIO OF THE MOLECULAR
WEIGHTS (114.5/100.13). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254. 1-38
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY) January 1992
Subchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfO] [RfC] [RfD] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mg/cu m) (mg/kg/day) (ng/cu m) (na/kg/day)
UF UF UF UF
ETHYL-0-XYLENE ,4- 000934-80-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 008882
ETHYLANILINE, N- 000103-69-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005958
ETHYLENE CYANOHYDRIN 000109-78-4
NOEL 30 MG/KG/DAY RAT 3E-1 3E-1 005780
ORAL: DRINKING 90 DAYS HEART DECREASED WEIGHT 100 100
WATER BRAIN DECREASED WEIGHT
ETHYLENE DIAMINE 000107-15-3
NOAEL 22.6 • MG/KG/DAY RAT 2E-1 IRIS 2E-2 005796
ORAL: DIET 3 MONTHS HEART DECREASED WEIGHT 100 1000
BLOOD HEMATOLOGIC CHANGES
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (5/1/91) BY THE RfD/RfC WORKGROUP.
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ETHYLENE GLYCOL 000107-21-1
IRIS 00545A
NOEL 200 MG/KG/DAY RAT 2E+0 005452
ORAL: DIET FETUS FETOTOXICITY 100
SUBCHRONIC [RfD] COMMENT: BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
ETHYLENE GLYCOL MONOBUTYL ETHER 000111-76-2
NOAEL 121 MG/CU M RAT 2E-1 2E-2 010353
INHALATION: 13 WEEKS BLOOD ALTERED HEMATOLOGY 100 1000
INTERMITTENT
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254. 1-39
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/lcg/day) (mg/cu m) (mg/lcg/day)
UF
UF
UF
UF
ETHYLENE THIOUREA
LOAEL 0.25 MG/KG/DAY
ORAL: DIET
000096-45-7
RAT
24 MONTHS
THYROID
HYPERPLASIA
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ETHYLTOLUENE, M- 000620-14-4
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ETHYLTOLUENE, 0- 000611-14-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
ETHYLTOLUENE, P- 000622-96-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
FLUORANTHENE
NOAEL 125 MG/KG/DAY MOUSE
ORAL: GAVAGE 90 DAYS
FLUORENE
NOAEL 125 MG/KG/DAY MOUSE
ORAL: GAVAGE 13 WEEKS
000206-44-0
KIDNEY
LIVER
BLOOD
000086-73-7
ERYTHROCYTES
NEPHROPATHY
INCREASED WEIGHT
HEHATOLOGICAL CHANGES
DECREASED COUNTS
8E-5
3000
4E-1
300
4E-1
300
IRIS
IRIS
IRIS
010397
005963
005962
005964
010168
010169
FLUORIDE
NOAEL 0.06 MG/KG/DAY
ORAL: DRINKING
WATER
HUMAN
007782-41-4
TOOTH
FLUOROSIS
6E-2
1
IRIS
005965
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-40
-------
CHEMICAL DOSE
LEVEL ROUTE
FLURIDONE
NOEL 200 PPM
ORAL: DIET
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
REFERENCE
SPECIES
EXPERIMENT LENGTH TARGET
RAT
2 YEARS
059756-60-4
KIDNEY
TEST IS
WHOLE BODY
ORGANS
CRITICAL EFFECT
GLOMERUIONEPHRITIS
ATROPHY
DECREASED WEIGHT
DECREASED WEIGHT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD]
(mg/cu m) (qg/kg/day) (na/cu m) (ing/kg/day)
UF
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
000133-07-3
FOLPET
NOEL 10 MG/KG/DAY DOG
ORAL: CAPSULE 1 YEAR
WHOLE BODY
BLOOD
ALTERED WEIGHT GAIN
ALTERED CHEMISTRY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL {RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
FORMALDEHYDE
NOAEL 15 MG/KG/DAY RAT
ORAL: DRINKING 2 YEARS
WATER
000050-00-0
LESIONS
DECREASED WEIGHT GAIN
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
GASTROINTES-
TINAL SYSTEM
WHOLE BODY
FORMALDEHYDE CYANOHYDRIN 000107-16-4
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
FORMIC ACID 000064-18-6
NOAEL 200 MG/KG/OAY RAT
ORAL: WATER MULT I- WHOLE BODY
GENERATION
DECREASED GROWTH
UF
8E-2
100
UF
1E-1
100
2E-1
100
2E+0
100
UF
IRIS
005966
IRIS
005967
IRIS
010398
2E+0
100
005782
010268
CHRONIC [RfD] COMMENT: BASED ON A MULT I-GENERATION STUDY. WITHDRAWN FROM IRIS (12/1/90). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
000110-00-9
IRIS 005462
FURAN
NOAEL 1.4 MG/KG/DAY
ORAL: GAVAGE
MOUSE
13 WEEKS
LIVER
LESIONS
1E-2
100
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-41
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfDJ REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
FURFURAL
LOAEL 7.9 MG/KG/DAY
ORAL: GAVAGE
000098-01-1
RAT
13 WEEKS
LIVER
HEPATOTOXICITY
3E-2
300
IRIS
005466
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
GLYCIDALDEHYDE
NOAEL 10 PPM
INHALATION:
'INTERMITTENT
RAT
12 WEEKS
000765-34-4
WHOLE BODY
BLOOD
KIDNEY
DECREASED WEIGHT GAIN
HEMATOPOIETIC EFFECTS
EFFECTS
1E-2
300
4E-3
300
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
HEPTACHLOR
NOEL 0.15 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000076-44-8
LIVER
INCREASED WEIGHT
5E-4
300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
HEPTACHLOR EPOXIDE
LOAEL 0.0125 MG/KG/DAY DOG
ORAL: DIET 60 WEEKS
001024-57-3
LIVER
INCREASED RELATIVE WEIGHT
1.3E-5
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
1E-3
3000
IRIS
005968
IRIS
005506
IRIS
010399
HEPTANE, N- 000142-82-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
HEXABROMOBENZENE
NOAEL 2 MG/KG/DAY RAT
ORAL: DIET 12 WEEKS
000087-82-1
LIVER
INDUCED CARBOXYLESTERASE
ACTIVITY
2E-2
100
IRIS
005969
005970
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-42
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu ro) (mg/kg/day)
UF UF UF UF
HEXACHLOROBENZENE 000118-74-1
NOAEL 0.08 MG/KG/DAY RAT
ORAL: DIET 130 WEEKS LIVER
EFFECTS
8E-4
100
IRIS
IRIS
005510
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (3/1/91) BY THE RfD/RfC WORKGROUP.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGEN!CITY.
HEXACHLOROBUTADIENE
NOAEL 0.2 MG/KG/DAY RAT
ORAL: DIET 2 YEAR
000087-68-3
KIDNEY
TOXICITY
2E-3
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
HEXACHLOROCYCLOHEXANE, DELTA- AND EPSILON-
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
000058-89-9
HEXACHLOROCYCLOHEXANE, GAMMA-
NOAEL 0.33 MG/KG/DAY RAT
ORAL: DIET 12 WEEKS LIVER
KIDNEY
TOXICITY
TOXICITY
3E-3
100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
HEXACHLOROCYCLOPENTADIENE 000077-47-4
NOAEL 0.15 PPM RAT
INHALATION: 13 WEEKS RESPIRATORY LESIONS
INTERMITTENT TRACT
FORESTOMACH LESIONS
000067-72-1
KIDNEY EFFECTS
7E-4
100
NOAEL 7.1 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS
HEXACHLOROETHANE
NOAEL 1 MG/KG/DAY RAT
ORAL: DIET 16 WEEKS
7E-2
100
1E-2
100
IRIS
0055H
IRIS
002222
005537
7E-5
1000
IRIS
IRIS
010445
005299
005518
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE, IRIS INPUT PENDING.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-43
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfO] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF
UF
UF
UF
HEXACHLOROPHENE
LOAEL 0.75 MG/KG/DAY DOG
ORAL: DIET 13 WEEKS
000070-30-4
NERVOUS SYSTEM EFFECTS
3E-3
300
IRIS
HEXAMETHYLENE DIAMINE 000124-09-4
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
HEXANE, N-
LOAEL 570 MG/KG/DAY
ORAL: GAVAGE
LOAEL
73 MG/CU M
INHALATION:
INTERMITTENT
RAT
90 DAYS
HUMAN
000110-54-3
NERVOUS SYSTEM
TESTIS
WHOLE BODY
NEUROPATHY
ATROPHY
DECREASED WEIGHT GAIN
6E-1
1000
6E-2
10000
NERVOUS SYSTEM NEUROTOXICITY
2E-1
300
IRIS
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
HEXANONE, 2- 000591-78-6
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
HYDROGEN SULFIDE
NOAEL 42 MG/CU M
INHALATION:
INTERMITTENT
MOUSE
13 WEEKS
NOAEL 3.1 MG/KG/DAY PIG
ORAL: DIET 105 DAYS
007783-06-4
NASAL MUCOSA
GASTROINTES-
TINAL SYSTEM
INFLAMMATION
DISTURBANCE
9E-3
100
IRIS
3E-2
100
IRIS
HYDROQUINONE
NOAEL 4.29 MG/KG/DAY HUMAN
ORAL: DIET 3-5 MONTHS BLOOD
IRIS
000123-31-9
HEMATOLOGICAL EFFECTS
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (10/1/90) BY THE RfD/RfC WORKGROUP.
4E-1
10
4E-2
100
IRON 007439-89-6
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
005972
005973
005974
010273
005976
010354
010269
005526
005527
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-44
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mgAg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
ISOBUTYL ALCOHOL
NOEL 316 MG/KG/DAY RAT
ORAL: DIET 13 WEEKS
ISOPHORONE
NOEL 150 MG/KG/DAY DOG
ORAL: CAPSULE 90 DAYS
000078-83-1
NERVOUS SYSTEM
NERVOUS SYSTEM
000078-59-1
KIDNEY
HYPOACTIVITY
ATAXIA
LESIONS
3E+0
100
2E+0
100
IRIS
IRIS
IRIS
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (3/1/91) BY THE RfD/RfC WORKGROUP.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGEN I CITY.
ISOPROPALIN
NOEL 15 MG/KG/DAY
ORAL: DIET
LACTONITRILE
RAT
90 DAYS
033820-53-0
BLOOD
ORGANS,
UNSPECIFIED
000078-97-7
HEMATOLOGICAL EFFECTS
ALTERED WEIGHTS
1.5E-1
100
IRIS
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
LEAD 007439-92-1
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
CHRONIC [RfD] COMMENT: REFER TO IRIS.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGEN I CITY.
LEAD ALKYLSCDIMETHYLETHYL LEAD, METHYLTRIETHYL LEAD, TETRABUTYL LEAD, TETRAETHYL LEAD, TETRAHETHYL LEAD,
TETRAPROPYL LEAD, TRIETHYL LEAD, TRIMETHYL LEAD, TRIMETHYLETHYL LEAD, AND TRIPROPYL LEAD)
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
CHRONIC [RfD] COMMENT: REFER TO IRIS.
LINDANE (See HEXACHLOROCYCLOHEXANE, GAMMA)
000330-55-2
LINURON
LOAEL 0.625 MG/KG/DAY DOG
ORAL: DIET 2 YEARS
BLOOD
ABNORMAL PIGMENTATION
2E-3
300
IRIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
005977
005910
005978
005783
910447
010447
910448
010448
005990
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-45
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfDJ [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/dav) (mg/cu m) (mg/kg/day)
UF
UF
UF
UF
MALATHION 000121-75-5
NOEL 0.23 MG/KG/DAY HUMAN
ORAL: CAPSULE 47 DAYS ERYTHROCYTES DECREASED CHOLINESTERASE
ACTIVITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfC] COMMENT: UNDER REVIEW.
MALEIC ANHYDRIDE
NOAEL 10 MG/KG/DAY
ORAL: DIET
000108-31-6
KIDNEY LESIONS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000123-33-1
KIDNEY ALTERED FUNCTION
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000109-77-3
MALEIC HYDRAZIDE
LOAEL 500 MG/KG/DAY
ORAL: DIET
RAT
2 YEARS
RAT
2 YEARS
MALONONITRILE
LOAEL 0.21 MG/KG/DAY RAT
ORAL: GAVAGE 120 DAYS
MANCOZEB
NOEL 2.9 MG/KG/DAY RAT
ORAL: DIET 90 WEEKS
MANEB
NOEL 5 MG/KG/DAY MONKEY
ORAL: DIET 6 MONTHS
LIVER
SPLEEN
008018-01-7
THYROID
012427-38-2
THYROID
EFFECTS
EFFECTS
GOITROGENIC EFFECTS
INCREASED WEIGHT
2E-2
10
1E-1
100
5E-1
1000
2E-4
1000
3E-2
100
5E-2
100
IRIS
IRIS
IRIS
2E-5
10000
3E-2
100
IRIS
005991
005992
005993
005994
005995
005996
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-46
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (na/cu m) (mg/kg/day)
UF
UF
UF
UF
MANGANESE
LOAEL 0.97 MG/CU M HUMAN
INHALATION:
INTERMITTENT
007439-96-5
LUNG
CENTRAL
NERVOUS SYSTEM
RESPIRATORY EFFECTS
PSYCHOMOTOR DISTURBANCES
4E-4
900
IRIS
010355
HUMAN
CENTRAL EFFECTS
NERVOUS SYSTEM
NOAEL 0.14 MG/KG/DAY
ORAL: DIET
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]
000950-10-7
MEPHOSFOLAN
NOEL 0.09 MG/KG/DAY RAT
ORAL: DIET 17 WEEKS
MERCURY, INORGANIC
NOAEL 0.009 MG/CU M HUMAN
INHALATION:
INTERMITTENT
LIVER
KIDNEY
BLOOD
ERYTHROCYTES
BRAIN
DECREASED WEIGHT
DECREASED WEIGHT
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
007439-97-6
NERVOUS SYSTEM NEUROTOXICITY
3E-4
30
1E-1
1
9E-4
100
3E-4
30
IRIS
9E-5
1000
010356
005997
010270
SUBCHRONIC [RfC] COMMENT: THIS VALUE IS SPECIFICALLY FOR ELEMENTAL MERCURY.
CHRONIC [RfC] COMMENT: THIS VALUE IS SPECIFICALLY FOR ELEMENTAL MERCURY. UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
RAT
ORAL,
PARENTERAL
KIDNEY
EFFECTS
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
MERPHOS 000150-50-5
NOEL 0.1 MG/KG/DAY HEN
ORAL: CAPSULE 3 MONTHS NERVOUS SYSTEM ATAXIA
NERVOUS SYSTEM DELAYED NEUROTOXICITY
WHOLE BODY DECREASED WEIGHT
3E-4
1000
3E-4
300
3E-4
1000
IRIS
005800
005998
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-47
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CHEMICAL DOSE
LEVEL ROUTE
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Siixhronic Chronic
[RfC] [RfD] [RfC] [RfD]
(mg/cu m) (TO/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
REFERENCE
MERPHOS OXIDE
NOEL 0.1 MG/KG/DAY HEN
ORAL: CAPSULE 3 MONTHS
METHACRYLONITRILE
NOAEL 3.2 PPM DOG
INHALATION: 90 DAYS
INTERMITTENT
000078-48-8
NERVOUS SYSTEM
NERVOUS SYSTEM
WHOLE BODY
000126-98-7
LIVER
LIVER
ATAXIA
DELAYED NEUROTOXICITY
DECREASED WEIGHT
INCREASED SCOT
INCREASED SGPT
3E-4
300
1E-3
300
IRIS
005999
IRIS
005812
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHANOL
NOEL 500 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000067-56-1
BLOOD
BLOOD
BRAIN
INCREASED ALKALINE
PHOSPHATASE
INCREASED SGPT
DECREASED WEIGHT
5E+0
100
IRIS
010271
METHOMYL
NOEL 2.5 MG/KG/DAY DOG
ORAL: DIET 24 MONTHS
016752-77-5
KIDNEY
SPLEEN
LESIONS
LESIONS
2.5E-2
100
IRIS
005802
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
METHOXYCHLOR 000072-43-5
NOEL 5.01 MG/KG/DAY RABBIT
ORAL: GAVAGE 13 DAYS REPRODUCTION
LOSS OF LITTERS
5E-3
1000
IRIS
010357
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A TERATOLOGY STUDY WITH EXPOSURES DURING DAYS 7-19 OF GESTATION.
CHRONIC [RfC] COMMENT: THE CHRONIC [RfC] WAS CONSIDERED NOT VERIFIABLE, IRIS INPUT PENDING.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-48
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
Sifcchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfO] [RfCl [RfO] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (na/cu m) (ing/kg/day) (tng/cu m) (mg/kq/day)
UF UF UF UF
METHOXYETHANOL, 2- 000109-86-4
NOAEL 93 HG/CU M RABBIT 2E-1 4E-2 IRIS 4E-3 010372
INHALATION: 13 WEEKS TESTIS LESIONS 100 100 1000
INTERMITTENT
SUBCHRONIC [RfO] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
METHOXYETHANOL ACETATE, 2- 000110-49-6
GENERAL COMMENT: SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHYL ACETATE 000079-20-9
NOEL 1156 MG/KG/DAY RAT 1E+1 1E+0 010002
ORAL: GAVAGE 90 DAYS LIVER INCREASED ALKALINE 100 1000
PHOSPHATASE
LIVER INCREASED SGPT
LIVER INCREASED WEIGHT
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE. CALCULATED FROM DATA OBTAINED WITH METHANOL BY
MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (74.08/32.04)
METHYL ACRYLATE 000096-33-3
GENERAL COMMENT: SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHYL BROMIDE (See BROMOMETHANE)
METHYL CHLORIDE (See CHLOROMETHANE)
METHYL CHLOROCARBONATE 000079-22-1
010006
GENERAL COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513)569-7300; FTS 684-7300.
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (5/1/89)
METHYL ETHYL BENZENES (See ETHYL TOLUENE, m-, o- or p-)
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254. 1-49
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu m) (mg/kg/day) (cng/cu m) (mg/kg/day)
UF
UF
UF
UF
METHYL ETHYL KETONE
NOAEL 693 MG/CU M RAT
INHALATION: 12 WEEKS
INTERMITTENT
000078-93-3
NONE OBSERVED
5E-1
100
5E-2
1000
005558
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (8/1/91). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHYL ISOBUTYL KETONE
NOEL 50 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS
000108-10-1
LIVER
KIDNEY
EFFECTS
EFFECTS
5E-1
100
5E-2
1000
005563
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (3/1/91). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
SUBCHRONIC tRfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHYL ISOCYANATE
000624-83-9
IRIS
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (3/1/91) BYT THE RfD/RfC WORKGROUP.
022967-92-6
EFFECTS
METHYL MERCURY
LOAEL 0.003 MG HG/KG/DAY HUMAN
ORAL
CENTRAL
NERVOUS SYSTEM
3E-4
10
IRIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
CHRONIC [RfD] COMMENT: THE ADMINISTERED DOSE WAS CALCULATED FROM 200 NG HG/ML OF BLOOD.
METHYL METHACRYLATE 000080-62-6
NOEL 7.5 MG/KG/OAY RAT
ORAL: DRINKING 24 MONTHS KIDNEY
WATER
INCREASED RELATIVE WEIGHT
8E-2
100
8E-2
100
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
010013
005547
0100H
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-50
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
METHYL PARATHION
NOEL 0.25 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000298-00-0
BLOOD
BLOOD
ERYTHROCYTES
BLOOD
DECREASED HEMOGLOBIN
DECREASED HEMATOCRIT
DECREASED COUNT
DECREASED CHOLINESTERASE
ACTIVITY
2.5E-4
100
IRIS
010015
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
METHYL STYRENE, ALPHA- 000098-83-9
GENERAL COMMENT: SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHYL STYRENE (MIXED ISOMERS)
025013-15-4
GENERAL COMMENT: SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: UNDER REVIEW. ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY)
METHYL-4-CHLOROPHENOXYACETIC ACID,2-
(MCPA)
000094-74-6
NOEL
0.15 MG/KG/DAY
ORAL: DIET
DOG
52 WEEKS
KIDNEY
LIVER
EFFECTS
EFFECTS
5E-4
300
IRIS
010007
SUBCHRONIC [RfD] COMMENT:
THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
METHYL-4-CHLOROPHENOXY)BUTYRIC ACID,4-
(MCPB)
NOEL 12 MG/KG/DAY DOG
ORAL: DIET 13 WEEKS REPRODUCTIVE
SYSTEM
000094-81-5
NOEL
12 MG/KG/DAY
ORAL: DIET
RAT
13 WEEKS
LIVER
KIDNEY
TOXICITY
EFFECTS
EFFECTS
1E-1
100
IRIS
010008
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-51
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mq/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
METHYL-4-CHLOROPHENOXY)PROPIONIC ACID,2-(2-
(MCPP)
NOEL 3 MG/KG/DAY RAT
90 DAYS KIDNEY
000093-65-2
ORAL: DIET
METHYLCYCLOHEXANE
NOAEL 287 MG/CU M
INHALATION:
INTERMITTENT
000108-87-2
RAT
1 YEAR
KIDNEY
KIDNEY
INCREASED RELATIVE
WEIGHT
MINERALIZATION
PAPILLARY HYPERPLASIA
1E-2
300
3E+0
100
METHYLENE-BIS(2-CHLOROANILINE), 4,4'-
LOAEL 7.3 MG/KG/DAY DOG
ORAL: CAPSULE 9 YEARS LIVER
BLADDER
000101-14-4
EFFECTS
INFLAMMATION
7E-4
10000
3E+0
100
IRIS
7E-4
10000
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
METHYLENE BROMIDE 000074-95-3
(DIBROMOMETHANE)
CHRONIC [RfC] COMMENT: UNDER REVIEW.
GENERAL COMMENT: SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHYLENE CHLORIDE
NOAEL 694.8 MG/CU M RAT
INHALATION: 2 YEARS
INTERMITTENT
000075-09-2
LIVER TOXICITY
3E+0
100
3E+0
100
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
NOAEL 5.85 MG/KG/DAY RAT
ORAL: DRINKING 24 MONTHS LIVER
WATER
TOXICITY
6E-2
100
IRIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
010009
010431
010413
005552
005553
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-52
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/dav) (mg/cu m) (mg/kg/day)
UF UF UF UF
METHYLENEDIPHENYL ISOCYANATE, 4,4'-
NOAEL 0.2 MG/CU M RAT
INHALATION: 24 MONTHS NASAL CAVITY
INTERMITTENT
000101-68-8
LESIONS
2E-5
300
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
002385-85-5
MIREX
LOAEL 0.015 MG/KG/DAY
ORAL: DIET
VOLE,
PRAIRIE
MULTI- OFFSPRING
GENERATION
INCREASED MORTALITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
MOLINATE
NOEL 0.2 MG/KG/DAY
ORAL: GAVAGE
RAT
002212-67-1
REPRODUCTIVE
SYSTEM
TOXICITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
CHRONIC [RfD] COMMENT: BASED ON A REPRODUCTION STUDY.
MOLYBDENUM
LOAEL 0.14 MG/KG/DAY HUMAN
ORAL: WATER, DIET
007439-98-7
URINE
JOINTS
BLOOD
INCREASED URIC ACID
PAIN, SWELLING
DECREASED COPPER LEVELS
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
SUBCHRONIC [RfD] COMMENT: THE CHRONIC [RfD] WAS ADOPTED AS THE SUBCHRONIC [RfD].
MONOCHLOROBUTANE (See CHLOROBUTANE,!-)
2E-6
10000
2E-3
100
5E-3
30
2E-5
300
010449
IRIS
005569
IRIS
010017
5E-3
30
910414
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-53
-------
CHEHICAL DOSE
LEVEL ROUTE
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
REFERENCE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO]
(mg/cu 01) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
NAPHTHALENE
NOEL 50 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS
000091-20-3
WHOLE BODY DECREASED WEIGHT
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
4E-2
1000
4E-2
1000
NAPHTHOQUINONE, 1,4- 000130-15-4
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
NICKEL
NOAEL 100 PPM RAT
ORAL: DIET 2 YEARS
007440-02-0
WHOLE BODY
ORGANS, MAJOR
DECREASED WEIGHT
DECREASED WEIGHT
2E-2
300
IRIS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfC] COMMENT: UNDER REVIEW.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY (UNDER NICKEL REFINERY DUST AND NICKEL SUBSULFIDE).
NICOTINONITRILE 000100-54-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
NITRIC OXIDE 010102-43-9
REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
NITRITE
NOEL 10 PPM
ORAL: DRINKING
WATER
HUMAN
014797-65-0
BLOOD METHEMOGLOBINEMIA
1E-1
10
IRIS
010446
010020
005579
005584
905584
010021
SUBCHRONIC [RfD] COMMENT: THIS VALUE IS BASED ON NITRATE (NITROGEN) DATA FROM THE MOST SENSITIVE HUMAN POPULATION (INFANTS).
THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THIS VALUE IS BASED ON NITRATE (NITROGEN) DATA FROM THE MOST SENSITIVE HUMAN POPULATION (INFANTS).
NITROANILINE, M- 000099-09-2
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010400
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-54
-------
CHEMICAL DOSE
LEVEL ROUTE
HEAST TABLE 1: SUB CHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY) January 1992
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(na/cu m) (mg/kq/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
NITROANILINE, 0-
LOAEL 9.8 MG/CU M
INHALATION:
INTERMITTENT
RAT
4 WEEKS
000088-74-4
BLOOD
010022
HEMATOLOGICAL EFFECTS
2E-3
1000
6E-4
1000
2E-4
10000
6E-5
10000
SUBCHRONIC CRfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
NITROANILINE, P- 000100-01-6
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
NITROBENZENE
LOAEL 25 MG/CU M
000098-95-3
INHALATION:
INTERMITTENT
INHALATION:
INTERMITTENT
MOUSE
90 DAYS
RAT
90 DAYS
BLOOD
ADRENAL
KIDNEY
LIVER
BLOOD
ADRENAL
KIDNEY
LIVER
5E-3
1000
IRIS
010024
005589
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfD] COMMENT: THE ORAL [RfD], WHILE STILL AVAILABLE ON IRIS, IS BEING RECONSIDERED BY THE [RfD] WORKGROUP. BASED ON ROUTE
TO ROUTE EXTRAPOLATION.
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: UNDER REVIEW. ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY)
NITROFURANTOIN
NOAEL 300 PPM MOUSE
ORAL: DIET 13 WEEKS
000067-20-9
TESTIS
DEGENERATION
7E-1
100
7E-2
1000
005593
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-55
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
NITROGEN DIOXIDE
NOEL 10 PPM
ORAL: DRINKING
WATER
HUMAN
010102-44-0
BLOOD METHEMOGLOBINEMIA
1E+0
1
IRIS
010402
SUBCHRONIC [RfD] COMMENT: THIS VALUE IS BASED ON NITRATE (NITROGEN) DATA FROM THE MOST SENSITIVE HUMAN POPULATION (INFANTS).
THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THIS VALUE IS BASED ON NITRATE (NITROGEN) DATA FROM THE MOST SENSITIVE HUMAN POPULATION (INFANTS).
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
NITROGEN OXIDES
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS. 910402
NITROMETHANE 000075-52-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010026
NITROPHENOLS
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
NITROPROPANE, 2-
LOAEL 78 MG/CU M
INHALATION:
INTERMITTENT
000079-46-9
RAT
22 MONTHS
LIVER
LESIONS
2E-2
1000
IRIS
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC],
NITROSODIPHENYLAMINE, P- 000156-10-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
NITROTOLUENE, M-
LOAEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 6 MONTHS
000099-08-1
SPLEEN
LESIONS
1E-1
1000
1E-2
10000
SUBCHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH 0-NITROTOLUENE.
CHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH 0-NITROTOLUENE.
NITROTOLUENE, 0-
LOAEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 6 MONTHS
000088-72-2
SPLEEN
KIDNEY
LESIONS
LESIONS
1E-1
1000
1E-2
10000
005594
010374
010027
010029
010028
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-56
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu m) (ing/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
NITROTOLUENE, P-
LOAEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 6 MONTHS
000099-99-0
SPLEEN
LESIONS
1E-1
1000
1E-2
10000
SUBCHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH 0-NITROTOLUENE.
CHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH 0-NITROTOLUENE.
OCTABROMODIPHENYL ETHER
NOAEL 2.5 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
OCTAMETHYLPYROPHOSPHORAMIDE
NOAEL 0.02 MG/KG/DAY HUMAN '
ORAL AT LEAST
30 DAYS
032536-52-0
LIVER ENZYME INDUCTION
000152-16-9
BLOOD
DECREASED CHOLINESTERASE
ACTIVITY
3E-2
100
2E-3
10
IRIS
2E-3
10
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
OZONE 010028-15-6
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
PARALDEHYDE 000123-63-7
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PARATHION
NOAEL 0.064 MG/KG/DAY HUMAN
ORAL: CAPSULE 28 DAYS
000056-38-2
ERYTHROCYTES
DECREASED CHOLINESTERASE
ACTIVITY
6E-3
10
6E-3
10
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
PARTICULATE MATTER
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
PEBULATE
NOEL 5 MG/KG/DAY
ORAL: DIET
001114-71-2
RAT
SUBCHRONIC BLOOD
INCREASED CLOTTING TIME
5E-2
100
5E-2
100
010030
010032
010031
910031
010033
005598
905598
010036
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-57
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF
UF
UF
UF
PENDIMETHALIN
NOEL 12.5 MG/KG/DAY DOG
ORAL: CAPSULE 2 YEARS
040487-42-1
LIVER
LIVER
LIVER
LESIONS
INCREASED ALKALINE PHOSPHATASE
INCREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
032534-81-9
LIVER ALTERED ENZYME ACTIVITIES
000608-93-5
PENTABROMODIPHENYL ETHER
NOAEL 1.8 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
PENTACHLOROBENZENE
LOAEL 8.3 MG/KG/DAY RAT
ORAL: DIET 100 DAYS
LIVER
KIDNEY
TOXICITY
TOXICITY
PENTACHLOROCYCLOPENTADIENE 025329-35-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PENTACHLORONITROBENZENE
NOEL 0.75 MG/KG/DAY DOG
ORAL: DIET 2 YEARS
000082-68-8
LIVER TOXICITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGEN I CITY.
PENTACHLOROPHENOL
NOEL 3 MG/KG/DAY RAT
ORAL: GAVAGE 62 DAYS
000087-86-5
FETUS
FETOTOXICITY
4E-2
300
2E-2
100
8E-3
1000
3E-3
300
3E-2
100
IRIS
IRIS
IRIS
IRIS
IRIS
010037
010038
010039
005302
010040
005600
SUBCHRONIC [RfD] COMMENT: BASED ON A TERATOLOGY STUDY WITH EXPOSURE 62 DAYS PRIOR TO MATING AND THROUGHOUT GESTATION AND LACTATION.
CHRONIC [RfC] COMMENT: UNDER REVIEW.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGEN!CITY.
PENTACHLOROPROPENE, 1,1,2,3,3- 001600-37-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010041
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-58
-------
CHEMICAL DOSE
LEVEL ROUTE
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
REFERENCE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD]
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
PENTANE, N- 000109-66-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PHENANTHRENE 000085-01-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PHENOL
NOAEL 60 MG/KG/DAY RAT
ORAL: GAVAGE
000108-95-2
FETUS
DECREASED WEIGHT
6E-1
100
IRIS
005603
005604
005824
SUBCHRONIC [RfD] COMMENT: BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION. THE CHRONIC ORAL [RfD] WAS
ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE.
PHENYLENEDIAMINE, M-
NOEL 6 MG/KG/DAY RAT
ORAL: DRINKING 90 DAYS
WATER
000108-45-2
LIVER
LIVER
LESIONS
INCREASED RELATIVE WEIGHT
6E-2
100
IRIS
PHENYLENEDIAMINE, 0- 000095-54-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
000106-50-3
WHOLE BODY EFFECTS
000062-38-4
KIDNEY DAMAGE
PHENYLENEDIAMINE, P-
NOAEL 18.7 MG/KG/DAY RAT
ORAL: DIET 103 WEEKS
PHENYLMERCURIC ACETATE
NOAEL 0.0084 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
8E-5
100
1.9E-1
100
IRIS
010044
010042
010043
010277
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]. CALCULATED BY ANALOGY TO MERCURY BY
CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO MERCURY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
IRIS. EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-59
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchrom'c Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF
000298-02-2
PHORATE
NOAEL 0.033 MG/KG/DAY RAT
ORAL: DIET 13 WEEKS BLOOD CHOLINESTERASE INHIBITION
UF
2E-4
200
UF
UF
2E-4
200
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED FOR SUBCHRONIC EXPOSURE.
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
PHOSGENE
000075-44-5
IRIS
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (10/1/90) BY THE RfD/RfC WORKGROUP.
007803-51-2
WHOLE BODY DECREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
PHOSPHINE
NOEL 0.026 MG/KG/DAY
ORAL: DIET
RAT
2 YEARS
3E-4
100
IRIS
NOAEL 1.4 MG/CU M
INHALATION:
INTERMITTENT
PHOSPHORUS, WHITE
RAT
24 WKS
KIDNEY
007723-4-0
EFFECTS
3E-4
1000
3E-5
10000
IRIS
GENERAL COMMENT: FORMERLY LISTED AS PHOSPHORUS (INORGANIC COMPOUNDS).
PHOTOCHEMICAL OXIDANTS
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PHTHALIC ACID, M- 000121-91-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PHTHALIC ACID, 0- 000088-99-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
010403
010045
010174
010173
010452
010172
010047
010046
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-60
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
REFERENCE
010048
010049
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
PHTHALIC ACID, P- 000100-21-0
NOEL 142 MG/KG/DAY RAT
ORAL: DIET 2 YEARS BLADDER
PHTHALIC ANHYDRIDE 000085-44-9
LOAEL 1562 MG/KG/DAY MOUSE
ORAL: DIET 104 WEEKS LUNG
KIDNEY
CRITICAL EFFECT
HYPERPLASIA
HISTOPATHOLOGY
HISTOPATHOLOGY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE
POLYBROMINATED BIPHENYLS
LOAEL 0.07 MG/KG/DAY RAT
ORAL: GAVAGE 25 WEEKS LIVER
LIVER
INCREASED WEIGHT
LESIONS
[RfC] [RfD) [RfC]
(mg/cu ro) (mg/kg/dav) (mg/cu m)
UF UF UF
1E+0
100
2E+0
1000
SUBCHRONIC ORAL [RfD].
7E-5
1000
[RfD]
(mg/kg/day)
UF
1E+0
100
IRIS
7E-6
10000
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
POTASSIUM CYANIDE 000151-50-8
NOAEL 27 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
5E-2
500
IRIS
010050
010278
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC
ORAL [RfD] WAS ADOPTED AS THE SU8CHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
POTASSIUM SILVER CYANIDE
NOAEL 82.7 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000506-61-6
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
2E-1
500
IRIS
010279
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC
ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
PROFLURALIN
NOEL 3 MG/KG/DAY
ORAL: DIET
026399-36-0
RAT
SUBCHRONIC
NONE OBSERVED
6E-3
500
6E-3
500
010051
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-61
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN 1CITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERINENT LENGTH TARGET
CRITICAL EFFECT
SiAchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu in) (mg/kg/day) (mg/cu ml (mg/kg/day)
UF
UF
UF
UF
PRONAMIDE
NOEL 7.5 MG/KG/DAY
ORAL: DIET
DOG
2 YEARS
023950-58-5
• NONE OBSERVED
SUBCKRON1C [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
001918-16-7
PROPACHLOR
NOEL 13.3 MG/KG/DAY RAT
ORAL: DIET 90 DAYS
PROPAZINE
NOEL 5 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
WHOLE BODY
LIVER
000139-40-2
WHOLE BODY
DECREASED WEIGHT GAIN
INCREASED RELATIVE WEIGHT
DECREASED WEIGHT GAIN
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
PROPIONITRILE 000107-12-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PROPYL ALCOHOL, N- 000071-23-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
PROPYLENE GLYCOL
NOEL 50,000 PPM
ORAL: DIET
NOEL
6 %
ORAL: DIET
RAT
2 YEARS
RAT
20 WEEKS
000057-55-6
BLOOD
HEMATOLOGICAL EFFECTS
7.5E-2
100
1.3E-1
100
2E-2
300
3E+1
100
IRIS
IRIS
IRIS
2E+1
100
IRIS
KIDNEY LESIONS
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (6/1/91) BY THE RfD/RfC WORKGROUP.
052125-53-8
DECREASED WEIGHT GAIN
PROPYLENE GLYCOL MONOETHYL ETHER
NOEL 680 MG/KG/DAY RAT
ORAL: DRINKING 30 DAYS WHOLE BODY
WATER
7E+0
100
IRIS
7E-1
1000
010280
010175
010052
010053
005627
005631
005629
005488
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (6/1/91) BY THE RfD/RfC WORKGROUP.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-62
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
Subchronic Chronic
REFERENCE
010276
005486
010375
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
PROPYLENE GLYCOL MONOMETHYL ETHER 000107-98-2
NOAEL 1000 PPM RAT,
RABBIT
INHALATION: 13 WEEKS CENTRAL EFFECTS
INTERMITTENT NERVOUS SYSTEM
NOEL 947 MG/KG/DAY RAT
ORAL: GAVAGE 35 DAYS LIVER
KIDNEY
PROPYLENE OXIDE 000075-56-9
LOAEL 71 MG/CU M RAT
INHALATION: 2 YEARS NASAL
INTERMITTENT EPITHELIUM
HISTOPATHOLOGY
HISTOPATHOLOGY
EFFECTS
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
PYRENE 000129-00-0
NOAEL 75 MG/KG/DAY MOUSE
ORAL: GAVAGE 13 WKS KIDNEY
PYRIDINE 000110-86-1
NOAEL 1 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER
RDX (CYCLONITE) 000121-82-4
NOEL 0.3 MG/KG/DAY RAT
ORAL 105 WEEKS PROSTATE
EFFECTS
INCREASED WEIGHT
INFLAMMATION
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
RONNEL 000299-84-3
NOAEL 5 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LIVER
EFFECTS
[RfC] [RfD] [RfC]
(mg/cu m) (ing/kg/day) (mg/cu m)
UF UF UF
2E+1 IRIS
30
7E+0
100
3E-2 IRIS
100
AS THE SUBCHRONIC INHALATION [RfC].
3E-1
300
1E-2
100
3E-3
100
SUBCHRONIC ORAL [RfD] .
5E-2
100
[RfD]
(mg/kg/day)
UF
7E-1
1000
IRIS
IRIS
IRIS
5E-2
100
010176
010055
010056
010057
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-63
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] IRfD] REFERENCE
(mg/cu m) (ns/kg/day) (rag/cu m) (ing/kg/day)
UF UF UF UF
HUMAN
SELENIOUS ACID 007783-00-8
NOAEL 0.046 MG/KG/DAY HUMAN
ORAL: DIET WHOLE BODY SELENOSIS, CLINICAL
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
007782-49-2
WHOLE BODY SELENOSIS, CLINICAL
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000630-10-4
SELENOSIS
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (5/1/91). UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
007440-22-4
SKIN ARGYRIA
SELENIUM
NOAEL 0.853 MG/DAY
ORAL: DIET
SELENOUREA
0.072 MG/KG/DAY
SILVER
LOAEL 0.014 MG/KG/DAY
IV
HUMAN
5E-3
3
5E-3
3
5E-3
15
HUMAN
2-9 YEARS
5E-3
3
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A TOTAL IV DOSE OF 1 GRAM.
SILVER CYANIDE
NOAEL 55.7 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000506-64-9
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
1E-1
500
IRIS
010415
IRIS
010404
5E-3
15
IRIS
008880
010453
IRIS
010283
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC ORAL
[RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-64
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfO] REFERENCE
(na/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
SIMAZINE
NOEL 0.52 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000122-34-9
WHOLE BODY
BLOOD
DECREASED WEIGHT GAIN
HEMATOLOGICAL EFFECTS
2E-3
300
2E-3
300
010177
CHRONIC [RfO] COMMENT: WITHDRAWN FROM IRIS (9/1/91). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
SODIUM CYANIDE
NOAEL 20.4 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000143-33-9
WHOLE BODY
THYROID
NERVE
DECREASED WEIGHT
EFFECTS
MYELIN DEGENERATION
4E-2
500
IRIS
005640
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC
ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
SODIUM DIETHYLDITHIOCARBAMATE
NOEL 30 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000148-18-5
EYE
WHOLE BODY
SODIUM METAVANADATE
NOAEL 10 PPM RAT
ORAL: DRINKING 3 MONTHS
WATER
STRONTIUM, STABLE
NOAEL 263.1 MG/KG/DAY RAT
ORAL: DRINKING 3 YEARS
WATER
013718-26-8
KIDNEY
007440-24-6
BONE
CATARACTS
DECREASED WEIGHT
IMPAIRED FUNCTION
RACHITIC CHANGES
3E-1
100
1E-2
100
IRIS
1E-3
1000
8.8E-1
300
005644
005735
010406
NOAEL
CHRONIC [RfD] COMMENT: BASED ON RACHITIC CHANGES IN BONE IN A 3-YEAR STUDY IN RATS. UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
010405
524.6 MG/KG/DAY RAT
ORAL: DRINKING 9 WEEKS
WATER
BONE
RACHITIC CHANGES
1E+0
300
SUBCHRONIC [RfD] COMMENT: BASED ON RACHITIC CHANGES IN BONE IN A 9-WEEK STUDY IN RATS.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-65
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) Cmg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
STRYCHNINE
LOAEL/ .2.5 MG/KG/DAY RAT
PEL ORAL: GAVAGE 28 DAYS
000057-24-9
UNSPECIFIED
UNSPECIFIED
000100-42-5
STYRENE
NOAEL 200 MG/KG/DAY DOG
ORAL: GAVAGE 19 MONTHS ERYTHROCYTES
LIVER
TOXICITY
H1STOPATHOLOGY
EFFECTS
EFFECTS
3E-3
1000
2E+0
100
IRIS
IRIS
CHRONIC {RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
SUCCINONITRILE 000110-61-2
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT .
SULFUR OXIDES
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
SULFUR DIOXIDE 007446-09-5
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
SULFURIC ACID
NOAEL 0.066- MG/CU M
0.098
INHALATION
HUMAN
007664-93-9
RESPIRATORY
SYSTEM
EFFECTS
CHRONIC [RfC] COMMENT: REPORTED EFFECTS OCCURRED AT PORTAL OF ENTRY. ESTIMATES OF MG/DAY REFERENCE DOSES ARE INAPPROPRIATE
BECAUSE EFFECTS AT PORTAL OF ENTRY DEPEND ON CONCENTRATION IN AIR. AN ACCEPTABLE AIR CONCENTRATION
OF 0.07 MG/CU M WAS ESTIMATED BY CARSON ET AL (1981) FROM AVAILABLE DATA.
THIOCYANOMETHYLTHIO)-BENZOTHIAZOLE, 2-
(TCMTB)
NOEL 25 MG/KG/DAY RAT
ORAL: DIET SUBCHRONIC STOMACH
021564-17-0
LESIONS
3E-1
100
3E-2
1000
SUBCHRONIC [RfD] COMMENT: BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA.
CHRONIC [RfD] COMMENT: BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA.
010285
010059
005585
910059
905585
005647
010068
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-66
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN1CITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
TEMEPHOS
NOAEL 200 PPM
ORAL: DIET
SPECIES
EXPERIMENT LENGTH TARGET
RAT
99 DAYS
TERBUFOS
NOAEL 0.0025 MG/KG/DAY DOG
ORAL: DIET 6 MONTHS
003383-96-8
013071-79-9
CHOLINESTERASE
CRITICAL EFFECT
NONE OBSERVED
INHIBITION
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mq/cu m) (mg/kg/day) (ng/cu m) (mg/kg/day)
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
TEREPHTHALIC ACID 000100-21-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TETRACHLOROAZOXYBENZENE 021232-47-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TETRACHLOROBENZENE, 1,2,4,5-
NOAEL 0.34 MG/KG/DAY RAT
ORAL: DIET 13 WEEKS KIDNEY
000095-94-3
LESIONS
TETRACHLOROCYCLOPENTADIENE 000695-77-2
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TETRACHLOROETHANE, 1,1,1,2-
NOAEL 89.3 MG/KG/DAY RAT
ORAL: GAVAGE 103 WEEKS LIVER
KIDNEY
000630-20-6
LESIONS
LESIONS
UF
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000127-18-4
LIVER HEPATOTOXICITY
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGEN 1CITY.
TETRACHLOROETHYLENE
NOAEL 14 MG/KG/DAY MOUSE
ORAL 6 WEEKS
TETRACHLOROHYDRAZOBENZENE 071753-42-9
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
UF
UF
2E-1
100
2.5E-5
100
3E-3
100
3E-2
3000
1E-1
100
UF
2E-2
1000
2.5E-5
100
IRIS
IRIS
IRIS
010060
010408
008881
010064
010286
005303
010407
005650
010065
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-67
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEHICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu ro) (mg/kg/day)
UF
UF
UF
UF
TETRACHLOROPHENOL, 2,3,4,5- 004901-51-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TETRACHLOROPHENOL, 2,3,4,6-
NOAEL 25 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
000058-90-2
LIVER
LIVER
INCREASED WEIGHT
CENTRILOBULAR HYPERTROPHY
TETRACHLOROPHENOL, 2,3,5,6- 000935-95-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TETRACHLOROPROPENE, 1,1,2,3- 010436-39-2
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TETRACHLORVINPHOS (STIROFOS)
NOEL 3.1 MG/KG/DAY DOG
ORAL: DIET 2 YEARS LIVER
KIDNEY
WHOLE BODY
000961-11-5
INCREASED WEIGHT
INCREASED WEIGHT
DECREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfO] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TETRAETHYL DITHIOPYROPHOSPHATE
NOEL 0.5 MG/KG/DAY RAT
ORAL: DIET 3 MONTHS ERYTHROCYTES
BLOOD
TETRAETHYL LEAD (See LEAD ALKYLS)
001314-32-5
003689-24-5
DECREASED CHOLINESTERASE
ACTIVITY
DECREASED CHOLINESTERASE
ACTIVITY
THALLIC OXIDE
NOAEL 0.22 MG/KG/DAY RAT
ORAL:GAVAGE 90 DAYS
LIVER
BLOOD
INCREASED SCOT
INCREASED SERUM LDH
3E-1
100
3E-2
100
5E-3
100
7E-4
300
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (5/1/89). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
IRIS
IRIS
IRIS
7E-5
3000
005324
005323
005325
010066
010067
010287
005660
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-68
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (ing/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
THALLIUM (I) ACETATE 000563-68-8
NOAEL 0.26 MG/KC/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER
BLOOD
INCREASED SCOT
INCREASED SERUM LDH
9E-4
300
IRIS
SUBCHRONIC IRfD] COMMENT: CALCULATED
CHRONIC [RfD] COMMENT: CALCULATED BY
BY ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM (I) CARBONATE
NOAEL 0.23 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
006533-73-9
LIVER
BLOOD
INCREASED SCOT
INCREASED SERUM LDH
8E-4
300
IRIS
SUBCHRONIC {RfD] COMMENT: CALCULATED
CHRONIC [RfD] COMMENT: CALCULATED BY
BY ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM (I) CHLORIDE
NOAEL 0.23 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
007791-12-0
LIVER
BLOOD
INCREASED SCOT
INCREASED SERUM LDH
8E-4
300
IRIS
005664
005668
005672
SUBCHRONIC (RfD] COMMENT: CALCULATED
CHRONIC [RfD] COMMENT: CALCULATED BY
THALLIUM (IN SOLUBLE SALTS)
BY ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
CHRONIC [RfD] COMMENT: REFER TO IRIS FOR OTHER THALLIUM SALTS.
010102-45-1
THALLIUM(I) NITRATE
NOAEL
0.26 MG/KG/DAY
ORAL: GAVAGE
RAT
90 DAYS
LIVER
BLOOD
HAIR
INCREASED SCOT
INCREASED SERUM LDH
ALOPECIA
9E-4
300
IRIS
010458
005676
SUBCHRONIC [RfD] COMMENT: CALCULATED
CHRONIC [RfD] COMMENT: CALCULATED BY
BY ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-69
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu m) (mg/kg/day) (ma/cu m) (ma/kg/day)
UF UF UF UF
THALLIUM SELENITE
NOAEL 0.28 HG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
012039-52-0
LIVER
BLOOD
INCREASED SCOT
INCREASED SERUM LDH
9E-4
300
IRIS
005680
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
CHRONIC [RfD] COMMENT: THE ORAL [RfD], WHILE STILL AVAILABLE ON IRIS, IS BEING RECONSIDERED BY THE [RfD] WORK GROUP. CALCULATED BY ANALOGY
TO THALLIUM SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM(I) SULFATE
NOAEL 0.25 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS
THIOFANOX
NOAEL 0.025 MG/KG/DAY DOG
ORAL: GAVAGE 8 DAYS
007446-18-6
LIVER
BLOOD
039196-18-4
CHOL1NESTERASE
INCREASED SCOT
INCREASED SERUM LDH
DECREASED CHOLINESTERASE
ACTIVITY
8E-4
300
3E-4
100
IRIS
3E-4
100
SUBCHRONIC [RfD] COMMENT: BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA.
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE. BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA.
THIRAM
NOAEL 0.61 MG/KG/DAY FERRET
ORAL 24 WEEKS
TIN AND COMPOUNDS
NOAEL 2000 PPM RAT
ORAL: DIET 2 YEARS
000137-26-8
REPRODUCTION
LIVER
KIDNEY
IRIS
EFFECT
LESIONS
LESIONS
6E-3
100
6E-1
100
6E-1
100
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO STANNOUS CHLORIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO STANNOUS CHLORIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
005682
010069
010459
010070
005688
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-70
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfO] [RfC] [RfD] REFERENCE
(cng/cu ro) (cng/kg/day) (mg/cu m) (mg/kg/day)
UF
UF
UF
UF
TOLUENE
NOAEL 223
MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS
NOAEL
LOAEL
40 PPM
INHALATION
88 PPM
INHALATION
HUMAN
HUMAN
000108-88-3
LIVER
KIDNEY
CENTRAL
NERVOUS SYSTEM
EYES
NOSE
CENTRAL
NERVOUS SYSTEM
ALTERED WEIGHT
ALTERED WEIGHT
EFFECTS
IRRITATION
IRRITATION
NEUROLOGICAL
EFFECTS
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
TOLUENE-2,3-DIAMINE 002687-25-4
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TOLUENE-2,5-DIAMINE
NOAEL 56 MG/KG/DAY RAT
ORAL: DIET ' 78 WEEKS
000095-70-5
NONE OBSERVED
2E+0
100
IRIS
2E+0
100
4E-1
300
6E-1
100
SUBCHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE SULFATE SALT.
CHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE SULFATE SALT.
TOLUENE-2,6-DIAMINE
NOAEL 16 MG/KG/DAY RAT
ORAL: DIET 2 YEARS
000823-40-5
NONE OBSERVED
2E-1
100
SUBCHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE DIHYDROCHLORIDE.
CHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE DIHYDROCHLORIDE. '
TOLUENE-3,4-DIAMINE 000496-72-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TOLUIDINE, M- 000108-44-1
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
6E-1
100
2E-1
100
010469
005915
905915
010071
010073
010074
010072
010075
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-71
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(tng/cu ro) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF
UF
UF
UF
TRIALLATE 002303-17-5
NOAEL 1.275 MG/KG/DAY DOG
ORAL: DIET 24 MONTHS SPLEEN
LIVER
EFFECTS
EFFECTS
1.3E-2
100
IRIS
SUBCHRONIC [RfO] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000615-54-3
TRIBROMOBENZENE, 1,2,4-
NOAEL 5 MG/KG/DAY RAT
ORAL: DIET 45 OR 90
DAYS
LIVER
LIVER
INCREASED RELATIVE WEIGHT
ENZYME INDUCTION
5E-2
100
IRIS
TRIBROMETHANE (See BROMOFORM)
TRICHLOROBENZENE, 1,2,4-
NOAEL 100 PPM RAT
ORAL: DRINKING
WATER
000120-82-1
ADRENAL INCREASED WEIGHT
1E-2
1000
1E-2
1000
010076
010077
008885
SUBCHRONIC [RfD] COMMENT: BASED ON A MULTIGENERATION REPRODUCTION STUDY.
CHRONIC [RfD] COMMENT: BASED ON A MULT I GENERATIONAL REPRODUCTION STUDY. WITHDRAWN FROM IRIS (10/1/89). UNDER REVIEW, NUMBER SUBJECT TO
CHANGE.
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
TRICHLOROCYCLOPENTADIENE 077323-84-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TRICHLOROETHANE, 1,1,1-
NAOEL 500 PPM GUINEA PIG
ORAL 6 MONTHS LIVER
000071-55-6
HEPATOTOXICITY
9E-1
100
9E-2
1000
005304
005700
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. WITHDRAWN FROM IRIS (8/1/91). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: UNDER REVIEW. ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY)
1-72
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LEMGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(tng/cu m) (mg/kg/day) (cng/cu m) (mg/kg/day)
UF
UF
UF
UF
TRICHLOROETHANE, 1,1,2-
NOAEL 3.9 MG/KG/DAY MOUSE
ORAL: DRINKING 90 DAYS
WATER
000079-00-5
BLOOD
CLINICAL CHEMISTRY
ALTERATIONS
4E-2
100
IRIS
005702
CHRONIC [RfC] COMMENT: UNDER REVIEW.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TRICHLOROFLUOROMETHANE
000075-69-4
IRIS
LOAEL
1000 MG/KG/DAY
ORAL: GAVAGE
RAT
6 WEEKS
WHOLE BODY
DECREASED WEIGHT
7E-1
1000
005502
005500
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
TRICHLORO-2'-HYDROXYDIPHENYL ETHER, 2,4,4'- 003380-34-5
NOEL 500 MG/KG/DAY RAT
ORAL: GAVAGE 4 WEEKS WHOLE BODY DECREASED WEIGHT
TRICHLOROPHENOL, 2,3,4- 015950-66-0
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TRICHLOROPHENOL, 2,3,5- 000933-78-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TRICHLOROPHENOL, 2,3,6- 000933-75-5
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
4E+0
100
TRICHLOROPHENOL, 2,4,5-
NOEL 1000 PPM RAT
ORAL: DIET 98 DAYS
000095-95-4
LIVER
KIDNEY
EFFECTS
EFFECTS
1E+0
100
IRIS
IRIS
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (7/1/91) BY THE RfD/RfC WORKGROUP.
005492
005330
005331
005332
005329
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-73
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN I CITY) January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERINENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfO] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/dav)
UF
UF
UF
UF
TRICHLOROPHENOL, 2,4,6-
000088-06-2
IRIS
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (7/1/91) BY THE RfD/RfC WORKGROUP.
TRICHLOROPHENOL, 3,4,5- 000609-19-8
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TRICHLOROPHENOXY) PROPIONIC ACID, 2(2,4,5- 000093-72-1
NOEL 0.75 MG/KG/DAY DOG
ORAL: DIET 2 YEARS LIVER HISTOPATHOLOGY
8E-3
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
000093-76-5
TRICHLOROPHENOXYACETIC ACID, 2,4,5-
NOEL 10 MG/KG/DAY RAT
ORAL: DIET 90 DAYS KIDNEY
LIVER
WEIGHT EFFECTS
WEIGHT EFFECTS
TRICHLOROPROPANE, 1,1,1- 007789-89-1
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TRICHLOROPROPANE, 1,1,2-
NOEL 100 MG/L RAT
ORAL: DRINKING 13 WEEKS
WATER
000598-77-6
LIVER
KIDNEY
THYROID
LESIONS
LESIONS
LESIONS
TRICHLOROPROPANE, 1,2,2- 003175-23-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TRICHLOROPROPANE, 1,2,3-
NOAEL 8 MG/KG/DAY RAT
ORAL: GAVAGE 120 DAYS
000096-18-4
ERYTHROCYTES
BLOOD
DECREASED COUNT
ALTERED CHEMISTRIES
1E-1
100
5E-2
300
6E-2
100
IRIS
IRIS
IRIS
IRIS
010461
005333
010284
010179
010178
005705
005708
005706
005714
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-74
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Siijchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (TO/kg/day) (mg/cu m) (na/kg/day)
UF
UF
UF
UF
TRICHLOROPROPENE, 1,2,3-
NOEL 18 MG/CU M DOG
INHALATION: 66 WEEKS
INTERMITTENT
000096-19-5
EYE IRRITATION
5E-3
100
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
TRICHLOROTOLUENE, ALPHA,2,6-
LOAEL 0.5 PPM RAT
ORAL: DIET
28 DAYS
LIVER
KIDNEY
THYROID
002014-83-7
LESIONS
LESIONS
LESIONS
TRICHLOROTOLUENE, 2,3,6-
LOAEL 0.5 PPM RAT
ORAL: DIET 28 DAYS
002077-46-5
LIVER
KIDNEY
THYROID
LESIONS
LESIONS
LESIONS
5E-5
1000
5E-5
1000
TRICHLORO-1,2,2-TRIFLUOROETHANE, 1,1,2-
000076-13-1
NOEL
2000 PPM
INHALATION:
INTERMITTENT
RAT
24 MONTHS
WHOLE BODY
DECREASED WEIGHT
27E+0
100
3E+0
100
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.2.
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
TRIFLURALIN
NOEL 0.75 MG/KG/DAY DOG
ORAL: DIET 12 MONTHS
001582-09-8
LIVER
BLOOD
INCREASED WEIGHT
METHEMOGLOBINEMIA
7.5E-3
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY..
TRIMETHYLBENZENES
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
5E-3
100
IRIS
27E+0
100
IRIS
010078
005339
005335
010460
010376
010080
005727
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-75
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (ma/kg/day) (rog/cu m) (mg/kg/day)
UF
UF
UF
UF
TRINITROBENZENE, 1,3,5-
NOAEL 0.51 MG/KG/DAY RAT
ORAL: DRINKING 16 WEEKS
WATER
000099-35-4
SPLEEN
INCREASED WEIGHT
CHRONIC [RfD] COMMENT: CALCULATED FROM DATA OBTAINED WITH 1,3-DINITROBENZENE.
SUBCHRONIC [RfD] COMMENT: CALCULATED FROM DATA OBTAINED WITH 1.3-DINITROBENZENE.
TRINITROPHENOLS
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
TRINITROPHENYLMETHYLNITRAMINE
NOAEL 125 MG/KG/DAY RABBIT
ORAL: GAVAGE 9 MONTHS
000479-45-8
LIVER HISTOPATHOLOGICAL EFFECTS
KIDNEY HISTOPATHOLOGICAL EFFECTS
SPLEEN HISTOPATHOLOGICAL EFFECTS
TRINITROTOLUENE, 2,4,6-
LOAEL 0.5 MG/KG/DAY DOG
ORAL: CAPSULE 26 WEEKS
000118-96-7
LIVER EFFECTS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD],
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
VANADIUM
NOAEL 5 PPM
ORAL: DRINKING
WATER
007440-62-2
RAT
LIFETIME
NONE OBSERVED
VANADIUM PENTOXIDE
NOAEL 17.85 PPM RAT
ORAL: DIET 2.5 YEARS
5E-4
1000
1E-1
1000
5E-4
1000
7E-3
100
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
001314-62-1
HAIR DECREASED CYSTINE
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
036907-42-3
9E-3
100
VANADIUM SULFATE
2.24 MG/KG/DAY
ORAL: DRINKING
WATER
RAT
LIFETIME
2E-2
100
IRIS
1E-2
10000
IRIS
7E-3
100
IRIS
2E-2
100
010081
010082
010377
010416
005739
005743
008886
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-76
-------
CHEMICAL DOSE
LEVEL ROUTE
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
Chronic
[RfC] [RfD] [RfC]
CRITICAL EFFECT
January 1992
SPECIES
EXPERIMENT LENGTH TARGET
Subchronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/dav)
UF
UF
UF
UF
VERNAM
NOEL 1 MG/KG/DAY
ORAL: DIET
RAT
001929-77-7
WHOLE BODY DECREASED WEIGHT
COMMENT: FORMERLY LISTED AS VERMOLATE.
1E-2
100
VINYL ACETATE 000108-05-4
NOAEL 176 MG/CU M MOUSE
INHALATION:
INTERMITTENT
104 WEEKS NASAL CAVITY
LESIONS
2E-1
30
IRIS
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
NOAEL 100 MG/KG/DAY RAT
ORAL: DRINKING 2 YEARS WHOLE BODY ALTERED WEIGHT
WATER KIDNEY ALTERED WEIGHT
VINYL-1-CYCLOHEXENE, 4- 000100-40-3
DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT
1E+0
100
WARFARIN
LOAEL 2 MG/DAY
ORAL
HUMAN
000081-81-2
BLOOD INCREASED PROTHROMBIN TIME
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
3E-4
100
IRIS
1E+0
100
IRIS
XYLENE, M- 000108-38-3
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
NOAEL 250 MG/KG
ORAL: GAVAGE
RAT
103 WEEKS CENTRAL HYPERACTIVITY
NERVOUS SYSTEM
WHOLE BODY DECREASED WEIGHT
WHOLE BODY
2E+0
100
NOEL
500 MG/KG
ORAL: GAVAGE
RAT
13 WEEKS
NONE OBSERVED
4E+0
100
0100S3
010418
010417
010084
010409
010468
005755
005755
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-77
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCIN06ENICITY)
January 1992
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT
XYLENE, MIXTURE 001330-20-7
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT
NOEL 500 MG/KG RAT
ORAL: GAVAGE 13 WEEKS WHOLE BODY DECREASED WEIGHT
XYLENE, 0- 000095-47-6
NOEL 250 MG/KG RAT
ORAL: GAVAGE 103 WEEKS CENTRAL HYPERACTIVITY
NERVOUS SYSTEM
WHOLE BODY INCREASED MORTALITY
NOEL 500 MG/KG RAT
ORAL: GAVAGE 13 WEEKS WHOLE BODY DECREASED WEIGHT
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT
XYLENE, P- 000106-42-3
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT
ZINC (METALLIC) 007440-66-6
LOAEL 2.14 MG/KG/DAY HUMAN
ORAL BLOOD ANEMIA
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
ZINC CYANIDE 000557-21-1
NOAEL 24.3 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT
THYROID EFFECTS
NERVE MYELIN DEGENERATION
[RfC] [RfD] [RfC]
(mg/cu m) (mg/kg/day) (mg/cu m)
UF UF UF
VERIFIABLE (12/11/91) BY THE RfD/RfC WORK
4E+0
100
4E+0
100
VERIFIABLE (12/11/91) BY THE RfD/RfC WORK
VERIFIABLE (12/11/91) BY THE RfD/RfC WORK
2E-1
10
5E-2
500
[RfD]
(mg/kg/day)
UF
GROUP.
IRIS
2E+0
100
GROUP.
GROUP.
2E-1
10
IRIS
REFEREI
005918
005763
005751
005751
010467
010378
005767
010289
SUBCHRONIC [RfO] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
ZINC PHOSPHIDE 001314-84-7
LOAEL 3.48 MG/KG/DAY RAT
ORAL: DIET 13 WEEKS WHOLE BODY DECREASED WEIGHT
WHOLE BODY DECREASED FOOD INTAKE
3E-3
1000
IRIS
010290
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
1-78
-------
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN 1CITY) January 1992
Subchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfD] [RfC] [RfD] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
ZINEB 012122-67-7
LOAEL 25 MG/KG/DAY RAT 5E-2 IRIS 010085
ORAL: DIET 2 YEARS THYROID HYPERPLASIA 500
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
5 PPM RAT 7E-3 7E-3 005739
ORAL: DRINKING LIFETIME NONE OBSERVED 100 100
WATER
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254. 1-79
-------
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
Subchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfO] [RfC] [RfD] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT (mg/cu m) (ing/kg/day) (mg/cu m) (ma/kg/day)
UF UF UF UF
ACETONE CYANOHYDRIN 000075-86-5
NOEL 4.0 MG/KG/DAY
RAT 1E-1 1E-2 010432
INHALATION: 14 WEEKS CENTRAL EFFECTS 100 1000
INTERMITTENT NERVOUS SYSTEM
SUBCHRONIC [RfC] COMMENT: 4E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). AN ERROR IN THE UNCERTAINTY FACTOR THAT WAS
REPORTED IN HEED (1988) WAS CORRECTED.
CHRONIC [RfC] COMMENT: 4E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
ACETONITRILE 000075-05-8
NOAEL 100 PPM MOUSE 5E-1 5E-2 005208
INHALATION: 92 DAYS LIVER INCREASED RELATIVE WEIGHT 300 3000
INTERMITTENT
SUBCHRONIC [RfC] COMMENT: 1E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 1E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED. FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
ACETOPHENONE 000098-86-2
NOAEL 0.007 MG/CU M RAT 2E-4 2E-5 005211
INHALATION: 70 DAYS BLOOD VESSEL CONGESTION 100 1000
CONTINUOUS LIVER DYSTROPHY
BLOOD DECREASED AlBUMIN/GLOBULIN
RATIO
SUBCHRONIC [RfC] COMMENT: 5E-5 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 5E-6 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254. 2-1
-------
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic chronic
[RfC] [RfD] [RfC] [RfD]
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
REFERENCE
BARIUM
NOEL 0.8 MG/CU M
INHALATION:
INTERMITTENT
007440-39-3
RAT
4 MONTHS
FETUS
FETOTOXICITY
5E-3
100
5E-4
1000
005249
SUBCHRONIC [RfC] COMMENT: 1E-3 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). BASED ON A REPRODUCTION STUDY.
CHRONIC [RfC] COMMENT: 1E-4 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). BASED ON A REPRODUCTION STUDY. UNDER REVIEW, CURRENT
NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
CHLORO-1,3-BUTADIENE, 2-
NOAEL 10 PPM RAT
INHALATION: 2 YEARS
INTERMITTENT
000126-99-8
HAIR
WHOLE BODY
ALOPECIA
DECREASED WEIGHT GAIN
1E-1
100
2E-2
100
1E-1
100
2E-2
100
005878
SUBCHRONIC [RfC] COMMENT: 4E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 4E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION ASSUMING AN INHALATION ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION ASSUMING AN INHALATION ABSORPTION FACTOR OF 0.5.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE
EXTRAPOLATION TO THE ORAL [RfD] VALUES.
CHLOROBENZENE
LOAEL 75 PPM
INHALATION:
INTERMITTENT
RAT
120 DAYS
000108-90-7
LIVER
KIDNEY
EFFECTS
EFFECTS
2E-1
1000
2E-2
10000
005353
SUBCHRONIC [RfC] COMMENT: 5E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 5E-3 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
2-2
-------
CHEMICAL
LEVEL
DOSE
ROUTE
HEAST TABLE 2:
SPECIES
EXPERIMENT LENGTH TARGET
ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
January 1992
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfD] [RfC] [RfD]
Crog/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
REFERENCE
CYCLOPENTADIENE
NOEL 87.3 MG/KG/DAY
INHALATION:
INTERMITTENT
SUBCHRONIC [RfC]
GENERAL COMMENT:
RAT
194 DAYS
000542-92-7
LIVER
KIDNEY
LESIONS
LESIONS
3E+0
100
005401
COMMENT: 9E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
THE SUBCHRONIC INHALATION [RfC] VALUE WAS DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.
DICHLOROBENZENE,
NOEL 49 PPM
INHALATION:
INTERMITTENT
1,2-
RAT
UP TO 7
MONTHS
000095-50-1
WHOLE BODY
DECREASED WEIGHT GAIN
2E+0
100
2E-1
1000
005412
SUBCHRONIC [RfC] COMMENT: 4E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 4E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
DICHLORODIFLUOROMETHANE 000075-71-8
LOAEL 482.3 MG/KG/DAY GUINEA PIG
INHALATION: 6 WEEKS LIVER
INTERMITTENT
LESIONS
2E+0
1000
•2E-1
10000
005497
SUBCHRONIC [RfC] COMMENT: 5E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 5E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
DICHLOROETHANE,
NOEL 138 MG/KG/DAY
INHALATION:
INTERMITTENT
1,1-
CAT
13 WEEKS
000075-34-3
KIDNEY
DAMAGE
5E+0
100
5E-1
1000
005789
SUBCHRONIC [RfC] COMMENT: 1E+0 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 1E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY AND TABLE 3:
CARCINOGENICITY.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
2-3
-------
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Siijchronic Chronic
[RfC] [RfD] [RfC] [RfD] REFERENCE
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
DICYCLOPENTADIENE
LOAEL 1 PPM
INHALATION:
INTERMITTENT
000077-73-6
RAT
90 DAYS
LIVER
DYSFUNCTION
2E-3
1000
2E-4
10000
005424
SUBCHRONIC [RfC] COMMENT: 6E-4 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 6E-5 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
ETHOXYETHANOL ACETATE, 2- 000111-15-9
NOEL 30.1 G/KG/DAY RAT
INHALATION: DAY 6-18 FETUS
INTERMITTENT OF
GESTATION
DECREASED OSSIFICATION
3E-1
100
3E-1
100
005952
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. THE ORAL [RfD] WAS BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS
6-18 OF GESTATION.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION. THE ORAL [RfD] WAS BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS 6-
18 OF GESTATION.
GENERAL COMMENT: NO PHARMACOK1NETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES. ALSO SEE TABLE 1:
SUBCHRONIC AND CHRONIC TOXICITY.
ETHYLENE DIAMINE
NOAEL 59 PPM
INHALATION:
INTERMITTENT
RAT
30 DAYS
000107-15-3
WHOLE BODY
KIDNEY
LIVER
INCREASED MORTALITY
LESIONS
LESIONS
1E+0
100
005793
SUBCHRONIC [RfC] COMMENT: 3E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC INHALATION [RfC] VALUE WAS DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM INHALATION
METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
2-4
-------
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD]
(mq/cu ro) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
REFERENCE
FURFURAL
NOAEL 20 PPM
INHALATION:
INTERMITTENT
HAMSTER
13 WEEKS
000098-01-1
NASAL CAVITY
OLFACTORY DEGENERATION
5E-1
100
5E-2
1000
005465
SUBCHRONIC [RfC] COMMENT: 1E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 1E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
METHACRYLONITRILE
NOAEL 3.2 PPM
INHALATION:
INTERMITTENT
DOG
90 DAYS
000126-98-7
LIVER
LIVER
INCREASED SCOT
INCREASED SGPT
7E-3
300
7E-4
3000
005812
SUBCHRONIC [RfC] COMMENT: 2E-3 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). THE [RfC] VALUE DIFFERS FROM THE VALUE CITED IN THE
1987 HEED BECAUSE THE UNCERTAINTY FACTOR WAS CHANGED TO CORRESPOND TO THAT USED FOR THE ORAL [RfD] BY IRIS.
CHRONIC [RfC] COMMENT: 2E-4 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). THE [RfC] VALUE DIFFERS FROM THE VALUE CITED IN THE
1987 HEED BECAUSE THE UNCERTAINTY FACTOR WAS CHANGED TO CORRESPOND TO THAT USED FOR THE ORAL [RfD] BY IRIS.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
METHOXYETHANOL ACETATE, 2-
NOAEL 10 PPM RABBIT
INHALATION: 13 WEEKS
INTERMITTENT
000110-49-6
TESTIS
DEGENERATION
2E-2
100
2E-3
1000
010001
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5. CALCULATED FROM DATA OBTAINED WITH
METHOXYETHANOL CONVERTED BY MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (118.13/76.09).
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5. CALCULATED FROM DATA OBTAINED WITH
METHOXYETHANOL CONVERTED BY MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (118.13/76.09).
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD) VALUES.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
2-5
-------
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE SPECIES
LEVEL ROUTE EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Sifcchronic Chronic
[RfC] [RfD] [RfC] [RfD]
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
REFERENCE
METHYL ACRYLATE
NOEL 15 PPM
INHALATION:
INTERMITTENT
000096-33-3
RAT
2 YEARS
NONE OBSERVED
3E-2
100
3E-2
100
010003
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
METHYL ETHYL KETONE
NOAEL 693 MG/CU M RAT
INHALATION: 12 WEEKS
INTERMITTENT
000078-93-3
NONE OBSERVED
3E+0
100
3E-1
1000
005558
SUBCHRONIC [RfC] COMMENT: 9E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 9E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
METHYL ISOBUTYL KETONE
NOEL 50 PPM RAT
INHALATION: 90 DAYS
INTERMITTENT
000108-10-1
LIVER
KIDNEY
INCREASED WEIGHT
EFFECTS
8E-1
100
8E-2
1000
005562
SUBCHRONIC [RfC] COMMENT: 2E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 2E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
METHYL STYRENE, ALPHA-
NOEL 970 MG/CU M RAT
INHALATION: 197 DAYS
INTERMITTENT
000098-83-9
LIVER
KIDNEY
INCREASED WEIGHT
INCREASED WEIGHT
7E-1
100
7E-2
1000
010016
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
2-6
-------
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCIN06ENICITY) January 1992
Subchronic Chronic
CHEMICAL DOSE SPECIES [RfC] [RfD] [RfC] [RfO] REFERENCE
LEVEL ROUTE EXPERIHENT LENGTH TARGET CRITICAL EFFECT (mg/cu m) (mg/kg/day) (rog/cu in) (mg/kg/day)
UF UF UF UF
METHYL STYRENE (MIXED ISOMERS) 025013-15-4
LOAEL 11.2 MG/KG/DAY MOUSE 4E-2 4E-2 005566
INHALATION: 103 WEEKS NASAL CAVITY LESIONS 1000 1000
INTERMITTENT
SUBCHRONIC [RfC] COMMENT: 1E-2 MG/KG/DAY (SEE APPENDIX A-ll, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 1E-3 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.
LOAEL 5.6 MG/KG/DAY . MOUSE 6E-3 6E-3 005567
INHALATION: 103 WEEKS NASAL CAVITY LESIONS 1000 1000
INTERMITTENT
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION WITH AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION WITH AN ABSORPTION FACTOR OF 0.5. UNDER REVIEW, CURRENT NUMBER SUBJECT TO
CHANGE.
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
METHYLENE BROMIDE 000074-95-3
(DIBROMOMETHANE)
NOAEL 11 MG/KG/DAY RAT 1E-1 1E-2 010011
INHALATION: 90 DAYS BLOOD INCREASED CARBOXYHEMOGLOBIN 100 1000
INTERMITTENT
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION, INCLUDING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION, INCLUDING AN ABSORPTION FACTOR OF 0.5. UNDER REVIEW, CURRENT NUMBER SUBJECT TO
CHANGE.
GENERAL COMMENT: NO PHARMACOKINETIC DATA WERE PROVIDED TO JUSTIFY ROUTE TO ROUTE EXTRAPOLATION FOR THE ORAL [RfD] VALUES.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254. 2-7
-------
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
January 1992
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfO] [RfC] [RfO]
(mg/cu m) (ing/kg/day) (mg/cu m) (ng/kg/day)
UF UF UF UF
REFERENCE
NITROBENZENE
LOAEL 25 MG/CU M
INHALATION:
INTERMITTENT
MOUSE
90 DAYS
000098-95-3
BLOOD
ADRENAL
KIDNEY
LIVER
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
2E-2
1000
2E-3
10000
005589
INHALATION:
INTERMITTENT
RAT
90 DAYS
BLOOD
ADRENAL
KIDNEY
LIVER
HEMATOLOGICAL EFFECTS
LESIONS
LESIONS
LESIONS
SUBCHRONIC [RfC] COMMENT: 6E-4 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 6E-4 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
TRICHLOROBENZENE, 1,2,4-
NOEL 22.3 MG/CU M RAT
INHALATION: 3 MONTHS
INTERMITTENT
000120-82-1
LIVER PORPHYRIA
9E-2
100
9E-3
1000
010360
SUBCHRONIC [RfC] COMMENT: 3E-2 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 3E-3 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT .WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY.
TRICHLOROETHANE, 1,1,1-
NAOEL 500 PPM GUINEA PIG
ORAL 6 MONTHS
000071-55-6
LIVER
HEPATOTOXICITY
1E+1
100
1E+0
1000
005700
CHRONIC [RfC] COMMENT: 3E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
SUBCHRONIC [RfC] COMMENT: 3E+0 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
2-8
-------
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCIN06ENICITY)
CHEMICAL DOSE
LEVEL ROUTE
SPECIES
EXPERIMENT LENGTH TARGET
January 1992
CRITICAL EFFECT
Subchronic Chronic
[RfC] [RfD] [RfC] [RfD]
(mg/cu m) (mg/kg/day) (mg/cu m) (mg/kg/day)
UF UF UF UF
REFERENCE
TRICHLOROFLUOROMETHANE
LOAEL 1940 MG/KG/DAY DOG
INHALATION: 90 DAYS
CONTINUOUS
000075-69-4
KIDNEY
LUNG
INCREASED BUN
INFLAMMATION
7E+0
1000
7E-1
10000
005501
SUBCHRONIC [RfC] COMMENT: 2E+0 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
CHRONIC [RfC] COMMENT: 2E-1 MG/KG/DAY (SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST).
GENERAL COMMENT: THE SUBCHRONIC AND CHRONIC INHALATION [RfC] VALUES WERE DERIVED FROM METHODOLOGY THAT IS NOT CURRENT WITH THE INTERIM
INHALATION METHODOLOGY USED BY THE RfD/RfC WORK GROUP. ALSO SEE TABLE 1:
SUBCHRONIC AND CHRONIC TOXICITY.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
2-9
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'Cmg/kg/day)-
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu m)'1
ACEPHATE 030560-19-1
IRIS IRIS IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ACROLEIN
000107-02-8
IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
000079-06-1
ACRYLAMIDE
ORAL: DRINKING 2 YEARS
WATER RAT
IRIS
IRIS
4.5E+0
IRIS
010086
005001
IRIS 010087
MAMMARY TUMORS
THYROID TUMORS
UTERUS TUMORS
ORAL CAVITY TUMORS
CENTRAL NERVOUS TUMORS
SYSTEM
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
Inhalation [Unit Risk] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ACRYLONITRILE
ORAL
000107-13-1
IRIS
IRIS
HUMAN LUNG TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
IRIS
IRIS
INHALATION:
OCCUPATIONAL
2.4E-1
IRIS
005004
005003
ALACHLOR
ORAL:DIET
015972-60-8
MULTIPLE SITES
TUMORS
B2
8E-2
2.3E-6
010180
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
General Comment:' ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-1
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu m)'1
ALDRIN
ORAL: DIET
MOUSE
000309-00-2
LIVER
CARCINOMA
IRIS
IRIS
1.7E+1
IRIS
IRIS 005006
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
Inhalation [Unit Risk] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ALLYL CHLORIDE
000107-05-1
IRIS
010181
General Comment: FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 OR (202) 260-4761) FOR RCRA APPROVED NUMERIC
ASSESSMENT OF THIS COMPOUND.
ANILINE
000062-53-3
IRIS IRIS IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
000140-57-8
LIVER TUMORS
ARAMITE
ORAL: DIET
104 WKS
RAT
IRIS
IRIS
2.5E-2
IRIS
IRIS
010088
010206
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ARSENIC, INORGANIC
INHALATION:
OCCUPATIONAL HUMAN
007440-38-2
RESPIRATORY SYSTEM
IRIS
5.0E+1
IRIS
IRIS
005007
TUMORS
Inhalation [Slope] Comment: ASSUMED A 30% ABSORPTION OF INHALED ARSENIC. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ASBESTOS
INHALATION
ORAL
001332-21-4
IRIS
IRIS
IRIS
005919
005010
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-2
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)-
[UNIT RISK]
ORAL INHALATION REFERENCE
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/dayr1
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu m)'1
BENZO[A]PYRENE 000050-32-8
ORAL: DIET RAT.MOUSE FORESTOMACH TUMORS IRIS 5.8E+0
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
INHALATION: 96.4 WEEKS IRIS
INTERMITTENT HAMSTER RESPIRATORY TRACT TUMORS
1.7E-4
6.1E+0
005016
1.7E-3 007777
General Comment: FOR RCRA ACTIVITIES ONLY. CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 or (202) 260-4761) FOR RCRA APPROVED NUMERIC
ASSESSMENT OF THIS COMPOUND.
BENZO[B]FLUORANTHENE
BENZO[K]FLUORANTHENE
000205-99-2
000207-08-9
IRIS
IRIS
010183
010090
General Comment: FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 or (202) 260-4761) FOR RCRA APPROVED NUMERIC
ASSESSMENT OF THIS COMPOUND.
BENZOTRICHLORIDE
BENZYL CHLORIDE
BERYLLIUM
ORAL
INHALATION:
OCCUPATIONAL
HUMAN
000098-07-7
000100-44-7
007440-41-7
LUNG
IRIS IRIS
IRIS IRIS
IRIS IRIS
IRIS
IRIS
IRIS
IRIS
8.4E+0
010092
010093
005018
IRIS 005017
TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-4
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (rag/kg/day)-'(mg/kg/day)-
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu m)'1
BIS(CHLOROMETHYL) ETHER 000542-88-1
INHALATION: 10-100
INTERMITTENT DAYS
RAT RESPIRATORY SYSTEM TUMORS
IRIS IRIS
2.2E+2
IRIS
IRIS 005077
Oral [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
BIS(2-CHLOROETHYL) ETHER 000111-44-4
ORAL 560 DAYS
MOUSE LIVER
IRIS IRIS
1.1E+0
IRIS
IRIS 005076
TUMORS
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
BIS(2-CHLOROISOPROPYL) ETHER 039638-32-9
ORAL: GAVAGE 2 YEARS
MOUSE LIVER TUMORS
LUNG TUMORS
7E-2
3.5E-2
2E-6
1E-5 005080
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION (50% RESPIRATORY ABSORPTION).
General Comment: FORMERLY LISTED AS BIS(2-CHLORO-1-METHYL(ETHYL)ETHER). ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY).
BIS(2-ETHYLHEXYL)PHTHALATE 000117-81-7
IRIS IRIS IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
BROMODICHLOROMETHANE 000075-27-4
IRIS IRIS
IRIS
005120
005148
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
000590-60-2
2 YEARS B2 1.1E-1
RAT LIVER TUMORS
BROMOETHENE
(VINYL BROMIDE)
INHALATION:
INTERMITTENT
3.2E-5 010094
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-5
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] «ng/kg/day) '(mg/kg/dayr
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu m)'1
BROMOFORM
ORAL: GAVAGE
2 YEARS
RAT
000075-25-2
INTESTINE, LARGE
IRIS
IRIS
3.9E-3
IRIS
IRIS 005150
ADENOMATOUS POLYP
AOENOCARCINOMA
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-I1, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
BUTADIENE,1,3-
INHALATION:
INTERMITTENT
IRIS
1.8E+0
IRIS
009991
000106-99-0
MOUSE MULTIPLE SITES TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
BUTYL BENZYL PHTHLATE, N- 000085-68-7
IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CADMIUM 007440-43-9
005020
Oral [Slope] Comment: THERE IS INADEQUATE EVIDENCE TO QUANTITATIVELY EVALUATE THE CARCINOGENICITY OF THIS COMPOUND BY THE ORAL ROUTE.
005122
INHALATION:
OCCUPATIONAL
IRIS
6.1E+0
IRIS 005019
HUMAN
RESPIRATORY SYSTEM
TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CAPTAFOL
ORAL: DIET
MOUSE
002425-06-1
LYMPHATIC SYSTEM
LYMPHOSARCOMA
8.6E-3
2.4E-7
010095
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-6
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/tg/day)-'(mg/kg/day)-
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu •)-'
CAPTAN
000133-06-2
MULTIPLE SITES
ORAL: DIET MULTIPLE SITES TUMORS B2 3.5E-3
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
000086-74-8
TUMORS
1.0E-7
010184
CARBAZOLE
ORAL: DIET
96 WEEKS
MOUSE
82
2E-2
CARBON TETRACHLORIDE
ORAL: GAVAGE
LIVER
000056-23-5
LIVER
TUMORS
IRIS
IRIS
5.3E-2
5.7E-7
IRIS
010096
IRIS 005022
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
Inhalation [Unit Risk] Garment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. INCORPORATES AN ABSORPTION FACTOR OF 0.4.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHLORANIL
ORAL: DIET
CHLORDANE
ORAL: DIET
82 WEEKS
MOUSE
MOUSE
000118-75-2
LIVER
LUNG
000057-74-9
LIVER
TUMORS
TUMORS
CARCINOMA
IRIS
4.03E-1
IRIS
1.3E+0
1.2E-5
IRIS
010097
IRIS 005024
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHLORO-2-METHYLANILINE HYDROCHLORIDE, 4-
ORAL: DIET 18 MONTHS
MOUSE CARDIOVASCULAR
SYSTEM
CARDIOVASCULAR
SYSTEM
003165-93-3
B2
4.6E-1
1.3E-5
010419
HEMANGIOMA
HEMANGIOSARCOMA
IRIS, ERA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-7
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'(mg/kg/day)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu m)'1
CHLORO-2-METHYLANILINE, 4- 000095-69-2
ORAL: DIET 18 MONTHS
MOUSE CARDIOVASCULAR
SYSTEM
CARDIOVASCULAR
SYSTEM
B2
5.8E-1
1.6E-5
010098
HEMANGIOMA
HEMANGIOSARCOMA
Oral [Slope] Comment: BASED ON VASCULAR TUMORS IN MICE TREATED WITH 4- CHLORO-2-METHYLANILINE HYDROCHLORIDE.
CHLORODIBROMOMETHANE (See DIBROMOCHLOROMETHANE)
CHLOROETHENE (See VINYL CHLORIDE)
000067-66-3
CHLOROFORM
ORAL: DRINKING
WATER
ORAL: GAVAGE
78 WEEKS
MOUSE
IRIS
IRIS
IRIS
IRIS
8.1E-2
005036
IRIS 005035
LIVER
CARCINOMA
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOX1CITY (OTHER THAN CARCINOGENICITY).
CHLOROMETHANE
INHALATION: 24 MONTHS
INTERMITTENT MOUSE
000074-87-3
KIDNEY
1.3E-2
6.3E-3
3.7E-7
1.8E-6 005038
TUMORS
Oral [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHLOROMETHYL METHYL ETHER 000107-30-2
IRIS
005081
General Comment: FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 OR (202) 260-4761) FOR RCRA APPROVED NUMERIC
ASSESSMENT OF THIS COMPOUND.
CHLORONITROBENZENE, 0- 000088-73-3
ORAL: DIET 18 MONTHS
MOUSE LIVER
B2
2.5E-2
7.1E-7
010099
TUMORS
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-8
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (ng/kg/dayr'dog/kg/dayr
[UNIT RISK]
ORAL INHALATION
(ug/L)'1 (ug/cu m)'1
REFERENCE
CHLORONITROBENZENE, P- 000121-73-3
ORAL: DIET 18 MONTHS
CHLORTHALONIL
ORAL: DIET
MOUSE
27-32
MONTHS
RAT
CARDIOVASCULAR TUMORS
SYSTEM
001897-45-6
KIDNEY TUMORS
B2
B2
1.8E-2
1.1E-2
5.1E-7
3.1E-7
010100
010384
Oral [Slope] Garment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHROMIUM(VI)
INHALATION:
OCCUPATIONAL
IRIS
018540-29-9
HUMAN LUNG TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
CHRYSENE 000218-01-9
IRIS
4.1E+1
IRIS
005091
010185
General Comment: FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH'ASSESSMENT SECTION (FTS 260-4761 OF (202) 260-4761) FOR RCRA APPROVED NUMERIC
ASSESSMENT OF THIS COMPOUND. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
COKE OVEN EMISSIONS
INHALATION:
OCCUPATIONAL HUMAN
008007-45-2
LUNG
2.2E+0
IRIS
005039
TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: FORMERLY LISTED UNDER COAL TARS.
CREOSOTE, COAL TAR
008001-58-9
IRIS
.005042
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-9
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
CRESOL, M-
EXPERIMEMT LENGTH
SPECIES TARGET
CANCER
000108-39-4
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (ing/kg/day) '(mg/kg/day)
IRIS
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu •)-'
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CRESOL, 0- 000095-48-7
IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CRESOL, P- 000106-44-5
IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
000123-73-9
LIVER TUMOR
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
000072-54-8
CROTONALDEHYDE
ORAL: DRINKING 113 WKS
WATER RAT
IRIS 1.9E+0
5.4E-5
ODD
DDE
DDT
ORAL: DIET
000072-55-9
000050-29-3
MOUSE, RAT LIVER
TUMORS
IRIS IRIS
IRIS IRIS
IRIS IRIS
3.4E-1
IRIS
IRIS
IRIS
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010187
010186
010188
010190
010291
010292
IRIS 005044
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-10
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (rag/kg/dayr'dng/kg/dayr
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/Lr1 (ug/cu n)'1
DECABROMODIPHENYL ETHER 001163-19-5
(DECABROMODIPHENYL OXIDE)
IRIS
General Conment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
002303-16-4
B2
TUMORS
DIBENZO[A,H]ANTHRACENE 000053-70-3
IRIS
DIALLATE
ORAL
19 MONTHS
MOUSE LIVER
6.1E-2
1.7E-6
010102
010103
010191
General Comment: FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 OR (202) 260-4761) FOR RCRA APPROVED NUMERIC
ASSESSMENT OF THIS COMPOUND.
DIBROMO-3-CHLOROPROPANE, 1,2- 000096-12-8
ORAL: DIET RAT STOMACH TUMORS
KIDNEY TUMORS
LIVER TUMORS
INHALATION:
INTERMITTENT
RAT, MOUSE NASAL CAVITY
TUMORS
[EPA Group] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
DIBROMOCHLOROMETHANE 000124-48-1
ORAL: GAVAGE 105 WEEKS
MOUSE LIVER
B2
B2
B2
1.4E+0
4E-5
2.4E-3
8.4E-2
2.4E-6
010294
6.9E-7 009994
005152
TUMORS
General Comment: FORMERLY LISTED AS CHLORODIBROMOMETHANE. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY).
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-11
-------
HEAST TABLE 3: CARCINOGEN1CITY
January 1992
CHEHICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-'(B9/kg/day)
[UNIT RISK]
ORAL INHALATION REFERENCE
(U3/L)-1 (ug/CU •»-'
DIBROMOETHANE, 1,2-
ORAL
000106-93-4
IRIS IRIS
IRIS
NASAL CAVITY TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
INHALATION: 88-103
INTERMITTENT WEEKS
RAT
7.6E-1
DICHLORO-2-BUTENE, 1,4- 000764-41-0
INHALATION: 90 DAYS
INTERMITTENT RAT NASAL PASSAGES TUMORS
General Cotnnent: FORMERLY LISTED UNDER DICKLOROBUTENES
B2
9.3E+0
DICHLOROBENZENE, 1,4- 000106-46-7
ORAL: GAVAGE 103 WEEKS
MOUSE LIVER
2.4E-2
TUMORS
IRIS
6.8E-7
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
DICHLOROBENZIDINE,3,3'- 000091-94-1
DICHLOROETHANE, 1,1- 000075-34-3
IRIS IRIS
IRIS
IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHROMIC TOXICITY (OTHER THAN CARCINOGENICITY).
DICHLOROETHANE, 1,2- 000107-06-2
ORAL: GAVAGE 78 WEEKS
RAT CIRCULATORY SYSTEM SARCOMA
IRIS IRIS
9.1E-2
IRIS
IRIS
005818
005071
2.6E-3 005053
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
005050
005815
005055
IRIS 005058
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-12
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LEHGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)-
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)'1 (ug/cu a)'1
DICHLOROETHYLENE, 1,1-
ORAL
000075-35-4
INHALATION
12 MONTHS
MOUSE
IRIS
IRIS
IRIS
IRIS
1.2E+0
IRIS
005060
005059
KIDNEY
ADENOCARCINOMA
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOX1CITY (OTHER THAN CARCINOGENICITY).
DICHLOROMETHANE (See METHYLENE CHLORIDE)
000078-87-5
LIVER TUMORS
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
DICHLOROPROPANE, 1,2-
ORAL: GAVAGE
MOUSE
B2
6.8E-2
1.9E-6
005062
DICHLOROPROPENE, 1,3- 000542-75-6
ORAL: GAVAGE 104 WEEKS
RAT FORESTOMACH TUMORS
LIVER TUMORS
ADRENAL TUMORS
THYROID TUMORS
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
IRIS
1.8E-1
5.1E-6
010105
INHALATION:
INTERMITTENT
2 YEARS
MOUSE
IRIS
1.3E-1
3.7E-5 010104
LUNG
ADENOMA
Inhalation [Unit Risk] Comment: BASED ON BENIGN LUNG TUMORS IN MICE.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC.AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
DIELDRIN
ORAL: DIET
MOUSE
000060-57-1
LIVER
IRIS
IRIS
1.6E+1
IRIS
IRIS 005816
CARCINOMA
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
Inhalation [Unit Risk] Comment: BASED ON ROUTE-TO-ROUTE EXTRAPOLATION.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-13
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)-
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu m)'1
DIETHYLSTILBESTEROL
ORAL:DIET MOUSE
000056-53-1
MAMMARY GLAND
DIMETHOXYBENZIDINE, 3,3'- 000119-90-4
ORAL: DIET LIFETIME
HAMSTER FORESTOMACH
CARCINOMA
PAPILLOMA
DIMETHYLANILINE HYDROCHLORIDE, 2,4- 021436-96-4
ORAL: DIET 18 MONTHS
MOUSE LUNG TUMORS
DIMETHYLANILINE, 2,4- 000095-68-1
ORAL: DIET 18 MONTHS
MOUSE LUNG
B2
4.7E+3
1.4E-2
5.8E-1
7.5E-1
1.3E-1
4E-7
1.7E-5
2.1E-5
TUMORS
Oral [Slope] Comment: BASED ON A STUDY USING 2,4-DIMETHYLANILINE HYDROCHLORIDE RESULTING IN LUNG TUMORS IN MICE.
DIMETHYLBENZ[A]ANTHRACENE, 7,12- 000057-97-6
010296
010106
010108
010107
010297
General Comment: FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 OR (202) 260-4761) FOR RCRA APPROVED NUMERIC
ASSESSMENT OF THIS COMPOUND.
DIMETHYLBENZIDINE, 3,3'- 000119-93-7
ORAL: GAVAGE 30 DAYS
RAT MAMMARY
B2
9.2E+0
2.6E-4
010109
TUMORS
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-14
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-'(og/kg/day)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)' (ug/cu n)'
DIMETHYLHYDRAZINE, 1,1- 000057-14-7
ORAL: DRINKING LIFETIME
WATER HOUSE CARDIOVASCULAR
SYSTEM
B2
INHALATION:
INTERMITTENT MOUSE
RESPIRATORY
SYSTEM
SARCOMA
TUMORS
[EPA Group] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
DIMETHYLHYDRAZINE,1,2- 000077-78-1
ORAL: DRINKING LIFETIME
WATER MOUSE CARDIOVASCULAR
SYSTEM
B2
TUMORS
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
DIMETHYL SULFATE 000077-78-1
DINITROTOLUENE, 2,4-
000121-14-2
2.6E+0
3.5E+0
3.7E+1 3.7E+1
IRIS
IRIS IRIS
7.4E-5
IRIS
010110
1E-3 009992
1.1E-3 1.1E-2 009993
010112
005066
General Comment: LISTED AS "DINITROTOLUENE MIXTURE 2,4-/2,6-" ON IRIS. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY).
DINITROTOLUENE, 2,6-
000606-20-2
IRIS IRIS
IRIS
005068
General Comment: LISTED AS "DINITROTOLUENE MIXTURE, 2,4-/2,6-" ON IRIS. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY).
DIOXANE, 1,4-
000123-91-1
IRIS IRIS
IRIS
010298
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-15
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-'(mg/kg/day)-
QJNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu m)'1
DIPHENYLHYDRAZINE, 1,2- 000122-66-7
ORAL: DIET 2 YEARS
RAT LIVER
IRIS IRIS
8.0E-1
IRIS
IRIS 005070
TUMORS
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
DIRECT BLACK 38 001937-37-7
ORAL: DIET 93 DAYS
RAT LIVER TUMORS
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
002602-46-2
TUMORS
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
8.6E+0
2.4E-4
DIRECT BLUE 6
ORAL: DIET
91 DAYS
RAT LIVER
8.1E+0
2.3E-4
DIRECT BROWN 95 016071-86-6
ORAL: DIET 91 DAYS
RAT LIVER TUMORS
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
DIRECT SKY BLUE 6B 002610-05-1
9.3E+0
2.6E-4
B2
010113
010114
010115
010116
[EPA Group] Comment: BASED ON THE FACT THAT 3,3-DIMETHOXYBENZIDENE, A KNOWN EPA GROUP 82 CARCINOGEN, IS A METABOLITE OF DIRECT SKY BLUE 6B.
000106-89-8
EPICHLOROHYDRIN
ORAL: DRINKING
• WATER
INHALATION: 30 DAYS,
INTERMITTENT OBSERVED
FOR
LIFETIME
RAT
IRIS IRIS
IRIS
IRIS
4.2E-3
010198
IRIS 010117
NASAL CAVITY
TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-16
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-'(tng/kg/day)-
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu m) '
ETHYL ACRYLATE 000140-88-5
ORAL: GAVAGE 104 WEEKS
RAT FORESTOMACH TUMORS
[EPA Group] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
ETHYLENE CHLORIDE (See DICHLOROETHANE, 1,2-)
ETHYLENE DIBROMIDE (See DIBROMOETHANE,1,2-)
000075-21-8
B2
ETHYLENE OXIDE
INHALATION: 2 YEARS
INTERMITTENT RAT
B1
BLOOD
BRAIN
LEUKEMIA
GLIOMA
Inhalation [Unit Risk] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
ORAL: GAVAGE
LIFETIME,
TWICE
WEEKLY
RAT
81
STOMACH TUMORS
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
ETHYLENE THIOUREA 000096-45-7
ORAL: DIET 2 YEARS
MOUSE LIVER
B2
TUMORS
4.8E-2
1.4E-6
010118
3.5E-1
1E-4 010422
1.02E+0
2.9E-5
010421
6E-1
1.7E-5
010423
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
ETHYLNITROSOUREA
000759-73-9
B2
010426
[EPA Group] Comment: THE CRAVE WORK GROUP VERIFIED A B2 CANCER CLASSIFICATION
General Comment: FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 OR (202) 260-4761) FOR RCRA-APPROVED NUMERIC
ASSESSMENT OF THIS COMPOUND. UNDER REVIEW.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-17
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/dayr1
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-' (ug/cu m)'1
FOLPET
FORMALDEHYDE
INHALATION
000133-07-3
IRIS IRIS IRIS
General Comment: ALSO SEE KEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
000050-00-0
NASAL CAVITY TUMORS
24 MONTHS
RAT
IRIS
4.5E-2
Inhalation [Slope] Comment:
General Comment: ALSO SEE
SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
FURAZOLIDONE
ORAL: DIET
FURIUM
000067-45-8
MAMMARY TUMORS
General Comment: FORMERLY LISTED UNDER NITROFURANS
000531-82-8
BLOOD LEUKEMIA
LISTED UNDER NITROFURANS
000765-34-4
ORAL: DIET
45 WEEKS
RAT
28 WEEKS
MOUSE
B2
3.8E+0
1E-4
B2
5.0E+1
1.4E-3
General Comment: FORMERLY
GLYCIDALDEHYDE
IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
000076-44-8
LIVER CARCINOMA
HEPTACHLOR
ORAL: DIET
IRIS IRIS
4.5E+0
IRIS
MOUSE
010120
IRIS 010121
Inhalation [Slope] Comment:
General Comment: ALSO SEE
BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
005106
005108
010122
IRIS 005820
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-18
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-'(mg/kg/day)-
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu m)'1
HEPTACHLOR EPOXIDE
ORAL: DIET 18-24
MONTHS
HOUSE
001024-57-3
LIVER
IRIS
IRIS
9.1E+0
IRIS
IRIS 010424
CARCINOMA
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Conment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXIC1TY (OTHER THAN CARCINOGEN I CITY).
HEXACHLOROBENZENE
ORAL: DIET 2 YEARS
RAT
000118-74-1
LIVER
IRIS
IRIS
1.6E+0
IRIS
IRIS 010365
TUMORS
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENIC!TY>.
HEXACHLOROBUTADIENE
ORAL: DIET 22-24
MONTHS
RAT
000087-68-3
KIDNEY
IRIS
IRIS
7.8E-2
IRIS
IRIS 005088
TUMORS
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comnent: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
HEXACHLOROCYCLOHEXANE-TECHNICAL
ORAL: DIET 6-20
MONTHS
MOUSE LIVER
000608-73-1
IRIS IRIS 1.8E+0 IRIS IRIS
TUMORS
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
000319-84-6
IRIS IRIS 6.3E+0 IRIS
TUMORS
Inhalation [Slope] Conment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
010127
HEXACHLOROCYCLOHEXANE, ALPHA-
ORAL: DIET 24 WEEKS
MOUSE LIVER
IRIS 010123
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-19
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LEHGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-'
-------
HEAST TABLE 3: CARCINOGEN1CITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayX'dng/kg/day)-
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu •)-'
HYDRAZINE
ORAL
000302-01-2
INHALATION:
INTERMITTENT
1 YEAR
RAT NASAL CAVITY TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-I1, DOSE CONVERSIONS ON HEAST.
010034-93-2
IRIS IRIS
IRIS
1.7E+1
HYDRAZINE SULFATE
ORAL
INHALATION:
INTERMITTENT
1 YEAR
RAT
IRIS IRIS
IRIS
1.7E+1
NASAL CAVITY
TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: LISTED AS "HYDRAZINE" ON IRIS.
INDENO[1,2,3-CD]PYRENE 000193-39-5
IRIS
IRIS
010129
IRIS 010128
IRIS
010131
IRIS 010130
010192
General Comment: FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 OR (202) 260-4761) FOR RCRA APPROVED NUMERIC
ASSESSMENT OF THIS COMPOUND.
ISOPHORONE
000078-59-1
IRIS IRIS IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
LEAD 007439-92-1
IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
LINDANE (See HEXACHLOROCYCLOHEXANE, GAMMA-)
005094
005096
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-21
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP]
-------
HEAST TABLE 3: CARCIN06ENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR] [UNIT RISK]
[EPA ORAL INHALATION ORAL INHALATION REFERENCE
GROUP] (mg/kg/day) '(tng/kg/day)-1 (ug/L) ' (ug/cu m)-1
METHYLENE CHLORIDE
INHALATION
000075-09-2
IRIS
ORAL . IRIS IRIS IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN I CITY).
METHYLENE-BIS(N.N-DIMETHYL) ANILINE, 4,4'-
000101-61-1
IRIS IRIS
IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGEN I CITY).
METHYLENE-BIS(2-CHLOROANILINE), 4,4'- 000101-14-4
ORAL: DIET 2 YEARS B2
RAT LUNG TUMORS
1.3E-1
1.3E-1
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
000101-77-9
TUMORS
METHYLNITROSOUREA 000684-93-5
METHYLENEBISBENZENAMINE, 4,4'-
ORAL: DRINKING 2 YEARS
WATER RAT LIVER
2.5E-1
7.1E-6
B2
IRIS 005904
005100
010137
3.7E-6 3.7E-5 010425
010136
010427
[EPA Group] Comment: UNDER REVIEW. THE CRAVE WORK GROUP VERIFIED A B2 CANCER CLASSIFICATION.
General Comment: FOR RCRA ACTIVITIES ONLY, CONTACT THE HEALTH ASSESSMENT SECTION (FTS 260-4761 OR (202) 260-4761) FOR RCRA-APPROVED NUMERIC
ASSESSMENT FOR THIS COMPOUND.
MIREX
ORAL: DIET
2 YEARS
RAT
002385-85-5
LIVER
ADRENAL
62
1.8E+0
5.1E-5
005102
TUMORS
TUMORS
[EPA Group] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-23
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-'(mg/kg/day)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu m)'1
NIAGARA BLUE 4B
002429-74-5
B2 010141
[EPA Group] Comment: BASED ON THE FACT THAT 3,3-DIMETHOXYBENZIDENE, A KNOWN EPA GROUP B2 CARCINOGEN, IS A METABOLITE OF NIAGARA BLUE 4B.
NICKEL REFINERY DUST
INHALATION:
OCCUPATIONAL HUMAN
IRIS
8.4E-1
IRIS 005103
RESPIRATORY SYSTEM TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: FORMERLY LISTED AS NICKEL. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (UNDER NICKEL).
NICKEL SUBSULFIDE
INHALATION:
OCCUPATIONAL
HUMAN
012035-72-2
RESPIRATORY SYSTEM
IRIS
1.7E+0
IRIS 005768
TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: FORMERLY LISTED AS NICKEL. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (UNDER NICKEL).
NITROFURAZONE
ORAL: DIET
46 WEEKS
RAT
NITROPROPANE, 2-
INHALATION: 22 MONTHS
INTERMITTENT RAT LIVER
000059-87-0
MAMMARY
000079-46-9
1.5E+0
TUMORS
TUMORS
NITROSO-DI-N-BUTYLAMINE, N- 000924-16-3
ORAL: DRINKING LIFETIME
WATER MOUSE BLADDER TUMORS
ESOPHAGUS TUMORS
B2
B2
IRIS IRIS
A.3E-5
9.4E+0
5.4E+0
IRIS
005110
2.7E-3 010142
IRIS 010143
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-24
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
NITROSO-DI-N-PROPYLAMINE, N- 000621-64-7
NITROSODIETHANOLAMINE, N- 001116-54-7
000055-18-5
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-'(mg/kg/d8y)-
IRIS IRIS
IRIS IRIS
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L) ' (ug/cu m)-'
IRIS
IRIS
NITROSODIETHYLAMINE, N-
ORAL: DRINKING 6 OR 12
WATER MONTHS
RAT
NITROSODIMETHYLAMINE, N- 000062-75-9
ORAL: DRINKING
WATER RAT LIVER
IRIS IRIS
5.1E+1
IRIS
TUMORS
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-1I, DOSE CONVERSIONS ON HEAST.
NITROSODIPHENYLAMINE, N- 000086-30-6
NITROSOMETHYLETHYLAMINE, N- 010595-95-6
NITROSOMETHYLVINYLAMINE, N- 004549-40-0
ORAL: DRINKING RAT UPPER CARCINOMAS
WATER DIGESTIVE
TRACT
IRIS IRIS
IRIS IRIS
82
IRIS
IRIS
INHALATION
RAT
UPPER
RESPIRATORY
TRACT
CARCINOMAS
010147
010144
IRIS IRIS 1.5E+2 IRIS IRIS 010145
LIVER TUMORS
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
IRIS 010146
005112
010148
010149
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-25
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHENICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day)-'(mg/kg/day)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu or1
NITROSOPYRROLIDINE, N- 000930-55-2
ORAL: DIET LIFETIME
RAT LIVER TUMORS
IRIS IRIS
2.1E+0
IRIS
IRIS 010300
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
PARATHION 000056-38-2
IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
005116
PCBs (See POLYCHLORINATED BIPHENYLS)
PENTABROMO-6-CHLORO-CYCLOHEXANE, 1,2,3,4,5- 000087-84-3
ORAL: DIET
2 YEARS
RAT
2.3E-2
6.6E-7
INTESTINE, LARGE TUMORS
Oral [Slope] Comment: BASED ON RESULTS WITH THE ALPHA ISOMER.
PENTACHLORONITROBENZENE 000082-68-8
ORAL 72 WEEKS
MOUSE LIVER
2.6E-1
7.4E-6
TUMORS
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
PENTACHLOROPHENOL
000087-86-5
IRIS IRIS
IRIS
010150
010151
010381
General Comment: TECHNICAL GRADE PENTACHLOROPHENOL AND DOWCIDE EC-7 WERE TESTED. ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY).
PHENYLENEDIAMINE, 0- 000095-54-5
ORAL: DIET 548 DAYS
RAT LIVER
B2
4.7E-2
1.3E-6
010152
TUMORS
Oral [Slope] Comment: BASED ON LIVER TUMORS IN RATS TREATED WITH 0-PHENYLENEDIAMINE DIHYDROCHLORIDE.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-26
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)'
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu o)-1
PHENYLPHENOL, 2- 000090-43-7
ORAL: DIET 637 DAYS
RAT URINARY BLADDER
POLYBROMINATED BIPHENYLS
ORAL: GAVAGE 25 WEEKS
RAT LIVER
LIVER
TUMORS
B2
1.94E-3
8.9E+0
CARCINOMA
NEOPLASTIC NODULE
POLYCHLORINATED BIPHENYLS (PCBs) 001336-36-3
PROPYLENE OXIDE 000075-56-9
ORAL
INHALATION: 2 YEARS
INTERMITTENT MOUSE NASAL CAVITY
IRIS IRIS
IRIS IRIS
IRIS
1.3E-2
TUMORS
5.5E-8
2.5E-4
IRIS
IRIS
Inhalation [Slope] Comnent: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
QUINOLINE
ORAL: DIET
RDX (CYCLONITE)
20-40
WEEKS
RAT
000091-22-5
LIVER
000121-82-4
1.2E+1
3.5E-4
TUMORS
IRIS IRIS IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
SELENIUM SULFIDE 007446-34-6
IRIS
Oral [Slope] Comment: STUDY RESULTS WERE CONSIDERED INCONCLUSIVE FOR QUANTITATIVE RISK ASSESSMENT.
010153
010154
005118
010156
IRIS 010155
010158
010157
010194
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-27
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (ng/kg/dayr'dng/kg/day)-1
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu n>r'
SIMAZINE
ORAL: DIET
2 YEARS
RAT
000122-34-9
MAMMARY
1.2E-1
3.4E-6
010195
CARCINOMA
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
SODIUM DIETHYLDITHIOCARBAMATE
ORAL: DIET 77 WEEKS
MOUSE LIVER
2.7E-1
000148-18-5
c
TUMORS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
7.7E-6
005126
STYRENE
000100-42-5
General Comment: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300; FTS 684-7300.
ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TCDD, 2,3,7,8-
ORAL: DIET
720 DAYS
RAT
001746-01-6
RESPIRATORY TUMORS
SYSTEM
LIVER TUMORS
B2
1.5E+5
1.5E+5
4.5E+0
009994
3.3E-5 005128
(pg/cu m)'1
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
Inhalation [Unit Risk] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE. BASES ON ROUTE TO ROUTE EXTRAPOLATION. AN ABSORPTION FACTOR OF 75%
IS USED TO CALCULATE THE UNIT RISK FROM THE SLOPE FACTOR.
EPA Comment: B2 CLASSIFICATION IS FOR TCDD ALONE. MIXTURES OF PHENOXY HERBICIDES AND/OR CHLOROPHENOLS WITH 2,3,7,8-TCDD AS A CONTAMINANT
ARE CLASSIFIED AS B1 CARCINOGENS.
TETRACHLOROETHANE, 1,1,1,2- 000630-20-6
ORAL: GAVAGE 103 WEEKS
MOUSE LIVER TUMORS
IRIS
IRIS
2.6E-2
IRIS
IRIS 010302
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-28
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES
TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/day) '(mg/kg/day)
[UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)' (ug/cu m)"'
IRIS
IRIS
2.0E-1
IRIS
TETRACHLOROETHANE, 1,1,2,2- 000079-34-5
ORAL: GAVAGE 75 WEEKS
MOUSE LIVER CARCINOMA
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
TETRACHLOROETHYLENE 000127-18-4
(PERCHLOROETHYLENE)
General Comment: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300; FTS 684-7300.
ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TETRACHLOROTOLUENE, P, a,a,a-
ORAL: GAVAGE 17.5 WEEKS
MOUSE ADENOCARC1NOMA
TETRACHLORVINPHOS (STIROPHOS)
ORAL: DIET 560 DAYS
MOUSE LIVER
005216-25-1
TUMORS
000961-11-5
TUMORS
B2
2.0E+1
2.4E-2
5.7E-4
6.9E-7
[EPA Group] Comment: UNDER REVIEW, CLASSIFICATION SUBJECT TO CHANGE.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TOLUENE-2,4-DIAMINE
ORAL: DIET 84-103
WEEKS
RAT
000095-80-7
B2
3.2E+0
9.1E-5
MAMMARY
TOLUIDINE, 0- (See METHYLANILINE,2-)
000106-49-0
18 MONTHS
MOUSE LIVER
TUMORS
TOLUIDINE, P-
ORAL: DIET
1.9E-1
5.4E-6
IRIS 005130
009995
005028
010159
010160
010162
TUMORS
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-29
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)-1
(UNIT RISK]
ORAL INHALATION REFERENCE
(ug/L)"1 (ug/cu n)~'
TOXAPHENE
ORAL: DIET
18 MONTHS
MOUSE
008001-35-2
LIVER
IRIS
IRIS
1.1E+0
TUMORS
Inhalation [Slope] Comment: SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
Inhalation [Unit Risk] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
TRICHLOROANILINE, 2,4,6- 000634-93-5
ORAL: DIET 18 MONTHS
MOUSE VASCULAR SYSTEM
TUMORS
TRICHLOROANILINE HYDROCHLORIDE, 2,4,6- 033663-50-2
ORAL: DIET 18 MONTHS
. MOUSE VASCULAR SYSTEM TUMORS
TRICHLOROETHANE, 1,1,2- 000079-00-5
ORAL: GAVAGE 78 WEEKS
MOUSE LIVER
IRIS
3.4E-2
2.9E-2
IRIS
5.7E-2
CARCINOMA
IRIS
IRIS 005134
1E-6
8.2E-7
IRIS
0011.11
005142
IRIS 005144
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TRICHLOROETHYLENE 000079-01-6
General Comment: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300; FTS 684-7300.
TRICHLOROPHENOL, 2,4,6- 000088-06-2
ORAL: DIET 107 WEEKS
MOUSE BLOOD
IRIS
IRIS
1E-2
IRIS
009996
IRIS 010428
LEUKEMIA
Inhalation [Slope] Comment: BASED ON ROUTE TO ROUTE EXTRAPOLATION. SEE APPENDIX A-II, DOSE CONVERSIONS ON HEAST.
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
TRIFLURALIN
001582-09-8
IRIS IRIS IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
010163
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-30
-------
HEAST TABLE 3: CARCINOGENICITY
January 1992
CHEMICAL ROUTE
EXPERIMENT LENGTH
SPECIES TARGET
CANCER
[SLOPE FACTOR]
[EPA ORAL INHALATION
GROUP] (mg/kg/dayr'dng/kg/day)-
[UHIT RlSd
ORAL INHALATION REFERENCE
(ug/L)-1 (ug/cu m)'1
TRIMETHYL PHOSPHATE
ORAL: GAVAGE 103 WEEKS
MOUSE
000512-56-1
UTERUS
B2
3.7E-2
1.1E-6
TUMORS
TRINITROTOLUENE,2,4,6 (TNT) 000118-96-7
IRIS IRIS IRIS
General Comment: ALSO SEE HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
VINYL BROMIDE (See BROMOETHENE)
000075-01-4
010164
009990
VINYL CHLORIDE
ORAL: DIET
1001 DAYS
RAT LUNG
LIVER
1.9E+0
5.4E-5
TUMORS
TUMORS
Oral [Slope] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
1 YEAR
RAT
INHALATION:
INTERMITTENT
3.0E-1
010368
8.4E-5 010367
LIVER
TUMORS
Inhalation [Unit Risk] Comment: UNDER REVIEW, NUMBER SUBJECT TO CHANGE.
General Comment: THE MOST RECENTLY REVIEWED QUANTITATIVE TOXICITY VALUES LISTED HERE APPEAR IN EPA DOCUMENTS PUBLISHED IN 1984 AND 1985.
USE OF THESE VALUES ON AN INTERIM BASIS WAS VALIDATED BY CRAVE (04/05/90). THE AGENCY IS AWARE THAT THESE VALUES DO NOT INCORPORATE
CONSIDERABLE INFORMATION THAT IS NOW AVAILABLE. THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT'S POSITION IS THAT THESE TOXICITY VALUES
DO NOT REFLECT STATE-OF-THE-ART SCIENCE FOR VINYL CHLORIDE. EPA NOW HAS INDIVIDUAL ANIMAL DATA, NOT AVAILABLE WHEN THE ORAL UNIT RISK WAS
CALCULATED, THAT MAY INFLUENCE THIS VALUE. ADDITIONAL INFORMATION THAT MAY BE FACTORED INTO A REVISED QUANTITATIVE TOXICITY VALUE INCLUDES
DATA ON INCREASED SENSITIVITY OBSERVED IN YOUNG ANIMALS AND DATA ON METABOLISH/PHARMACOKINETICS. A UNIT RISK FOR AIR THAT CONSIDERS
INFORMATION ON YOUNG AGE EXPOSURE INCREASES THE RISK (I.E., LOWERS THE RISK SPECIFIC DOSE) BY AT LEAST 3-FOLD. THE CONSIDERATION OF
METABOLISM PHARMACOKINETICS WILL FURTHER INCREASE THE RISK. ONE UNPUBLISHED PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODEL PREDICTION RESULTS
IN A 100-FOLD INCREASED RISK.
IRIS, EPA'S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254, FTS 684-7254.
3-31
-------
Table 4A: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Picocuries")
JANUARY 1992
Element
(Atomic Number) Isotope6
Actinium (89) Ac-225'
Ac-227t
Ac-227+D
Ac-228f
Americium (95) Am-241*
Am-242
Am-242m
Am-243f
Am-243+D
Antimony (51) Sb-122
Sb-124
Sb-125
Sb-126
Sb-126m
CASRN"
014265-85-1
014952-40-0
014952-40-0(4-0)
014331-83-0
014596-10-2
013981-54-9
013981-54-9(m)
014993-75-0
014993-75-0(+D)
014374-79-9
014683-10-4
014234-35-6
015756-32-8
015756-32-8(m)
Radioactive
Half-life8
1.000E+01
2.180E+01
2.180E+01
6.130E+00
4.320E+02
1.600E+01
1.520E+02
7.380E+03
7.380Et03
2.700E+00
6.020E+01
2.770E-I-00
1.240E+01
1.900E+01
D
Y
Y
H
Y
H
Y
Y
Y
D
D
Y
0
M
ICRP
Lung
Class1
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
G!
Absorption
Factor (f,)9
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.7E-11
2.8E-10
3.5E-10
5.0E-13
2.4E-10
3.6E-13
2.3E-10
2.4E-10
2.4E-10
2.0E-12
2.9E-12
8.4E-13
2.8E-12
7.2E-14
Inhalation
(Risk/pCi)
2.4E-09
8.0E-08
8.8E-08
2.6E-11
3.2E-08
1.2E-11
2.8E-08
3.2E-08
3.2E-08
3.4E-12
2.2E-1 1
1.1E-11
8.8E-12
2.6E-14
External Exposure
(Risk/yr per pCi/g soil)
7.6E-09
2.6E-1 1
8.5E-07
2.9E-06
4.9E-09
5.8E-09
1.2E-10
2.4E-08
2.5E-07
1.4E-06
6.5E-06
1.2E-06
9.1E-06
5.1E-06
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10" Ci.
c For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a *f are members of a decay chain.
" Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.
4A-1
-------
Table 4A: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Picocuries5)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Argon (18)
Astatine (85)
Barium (56)
Beryllium (4)
Bismuth (83)
Isotope*
Sb-127
Sb-129
Ar-41
At-217f
Ba-131
Ba-133
Ba-133m
Ba-137mt
Ba-139
Ba-140
Be-7
Bi-206
Bi-207
Bi-210f
CASRNd
013968-50-8
014331-88-5
014163-25-8
017239-90-6
014914-75-1
013981-41-4
013981-41-4(m)
013981-97-0(m)
014378-25-7
014798-08-4
013966-02-4
015776-19-9
013982-38-2
014331-79-4
Radioactive
Half-life6
3.850E+00
4.400E+00
1.830E+00
3.230E-02
1.180E+01
1.050E+01
3.890E-I-01
2.550E-fOO
8.310E+01
1.280E+01
5.340E+01
6.240E+00
3.340E+01
5.010E+00
D
H
H
S
D
Y
H
M
M
D
D
D
Y
D
ICRP
Lung
Class'
W
W
*
D
0
D
D
D
D
D
Y
W
W
W
Gl
Absorption
Factor (f,)fl
1.0E-01
1.0E-01
1.0E+00
1.0E+00
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
5.0E-03
5.0E-02
5.0E-02
5.0E-02
Ingestion
(Risk/pCi)
2.0E-12
5.9E-13
4.5E-18
4.8E-13
1.2E-12
6.2E-13
2.4E-15
2.1E-13
2.7E-12
3.0E-14
2.2E-12
1.4E-12
1.6E-12
Inhalation
(Risk/pCi)
4.1E-12
5.1E-13
5.8E-16
5.6E-17
3.6E-13
3.6E-12
3.5E-13
6.0E-16
1.5E-13
2.0E-12
2.7E-13
4.3E-12
1.8E-11
8.0E-1 1
External Exposure
(Risk/yr per pCi/g soil)
2.1E-06
4.9E-06
4.4E-06
7.7E-10
1.2E-06
8.4E-07
9.5E-08
2.0E-06
7.7E-08
5.4E-07
1.5E-07
1.1E-05
4.9E-06
O.OE+00
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10'12 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a T are members of a decay chain.
" Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-2
-------
Table 4A: Radionuclide Carcinogenicity •- Slope Factors'
(In Units of Picocuriesb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Bromine (35)
Cadmium (20)
Calcium (20)
Carbon (6)
Cerium (58)
Isotope0
81-211*
Bi-212f
Bi-213f
Bi-214f
Br-82
Cd-109
Cd-115
Cd-115m
Ca-45
Ca-47
C-11
C-14
C-15
Ce-141
CASRN"
015229-37-5
014913-49-6
015776-20-2
014733-03-0
014666-69-2
014109-32-1
014336-68-6
014336-68-6(01)
013966-05-7
001439-99-2
014333-33-6
014762-75-5
015929-2*4
013967-74-3
Radioactive
Half-life8
2.130E+00
6.055E+01
4.570E+01
1.990E+01
3.530E+01
4.640E+02
5.350E+01
4.460E+01
1.630E+02
4.540E-I-00
2.050E+01
5.730E+03
2.450E+00
3.250E+01
M
M
M
M
H
D
H
D
D
D
M
Y
S
D
ICRP
Lung
Class'
W
W
W
W
D
Y
Y
Y
W
W
D
•
D
Y
Gl
Absorption
Factor (f,)9
5.0E-02
5.0E-02
5.0E-02
5.0E-02
1.0E+00
5.0E-02
5.0E-02
5.0E-02
3.0E-01
3.0E-01
1.0E+00
1.0E+00
1.0E+00
3.0E-04
Ingestion
(Risk/pCi)
1.2E-14
3.1E-13
2.3E-13
1.3E-13
1.1E-12
7.9E-12
1.7E-12
5.2E-12
9.9E-13
2.0E-12
4.9E-14
9.0E-13
8.1E-16
8.3E-13
Inhalation
(Risk/pCi)
1.9E-13
6.6E-12
3.0E-13
2.1E-12
8.7E-13
6.5E-11
2.6E-12
3.9E-1 1
5.1E-12
4.6E-12
2.1E-14
6.4E-15
2.1E-16
8.4E-12
External Exposure
(Risk/yr per pCi/g soil)
1.3E-07
5.9E-07
4.1E-07
5.3E-06
8.9E-06
7.3E-10
6.3E-07
7.5E-08
5.8E-18
3.6E-06
3.2E-06
O.OE+00
1.3E-07
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10"'2 Ci.
0 For each radionuclide listed, corresponding sbpe factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D* to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
9 Radioactive half-lite: S = Second, M = Minute, 0 = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclido.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope fadors. See the User's Guide for instructions. 4A-3
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuriesb)
JANUARY 1992
Element
(Atomic Number)
Cesium (55)
Chlorine (17)
Chromium (24)
Cobalt (27)
Isotope0
Ce-143
Ce-144
Cs-131
Cs-134
Cs-134m
Cs-135
Cs-136
Cs-137t
Cs-137+D
Cs-138
CI-36
CI-38
Cr-51
Co-57
CASRNd
014119-19-8
014762-78-8
014914-76-2
013967-70-9
013967-70-9(m)
015726-30-4
014234-29-8
010045-97-3
010045-97-3(+D)
015758-29-9
013981-43-6
014158-34-0
014392-02-0
013981-50-5
Radioactive
Half-life9
3.300E+01
2.840E+02
9.690E+00
2.060E+00
2.900E+00
2.300E+06
1.320E+01
3.020E+01
3.020E+01
3.220E+01
3.010E+05
3.720E+01
2.770E+01
2.710E+02
H
0
D
Y
H
Y
D
Y
Y
M
Y
M
D
D
ICRP
Lung
Class'
Y
Y
D
D
D
D
D
D
D
D
D
D
Y
Y
Gl
Absorption
Factor (f,)9
3.0E-04
3.0E-04
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E-01
3.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.3E-12
6.1E-12
1.4E-13
4.1E-11
4.1E-14
4.0E-12
6.7E-12
2.8E-11
2.8E-11
1.9E-13
1.8E-12
2.3E-13
4.3E-14
5.8E-13
Inhalation
(Risk/pCi)
2.2E-12
3.4E-10
1.0E-13
2.8E-1 1
3.9E-14
2.7E-12
4.6E-12
1.9E-11
1.9E-11
9.6E-14
1.4E-12
1.3E-13
3.0E-13
8.2E-12
External Exposure
(Risk/yr per pCi/g soil)
6.7E-07
2.5E-08
2.8E-09
5.2E-06
2.0E-08
O.OE+00
7.2E-06
O.OE+00
2.0E-06
8.3E-06
O.OE+00
5.7E-06
9.2E-08
1.9E-07
Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10'1Z Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D* to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+0), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided (or reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-4
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuriesb)
JANUARY 1992
Element
(Atomic Number)
Copper (29)
Curium (96)
Dysprosium (66)
Erbium (63)
Isotope6
Co-58
Co-58m
Co-60
Cu-64
Cm-242
Cm-243
Cm-244
Cm-245
Cm-246
Cm-247
Cm-248
Dy-165
Dy-166
Er-169
CASRNd
01381-38-9
01381-38-9(m)
010198-40-0
013981-25-4
015510-73-3
015757-87-6
013981-15-2
015621-76-8
015757-90-1
015758-32-4
015758-33-5
013967-64-1
015840-01-4
015840-13-8
Radioactive
Half-life6
7.080E+01
9.150E+00
5.270E+00
1.270E+01
1.630E+02
2.850E+01
1.810E+01
8.500E-I-03
4.750E+03
1.560E+07
3.390E+05
2.330E+00
8.160E+01
9.400E+00
D
H
Y
H
D
Y
Y
Y
Y
Y
Y
H
H
D
ICRP
Lung
Class'
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f ,)fl
3.0E-01
3.0E-01
3.0E-01
5.0E-01
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
3.0E-04
3.0E-04
3.0E-04
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.6E-12
3.2E-14
1.5E-11
1.7E-13
1.3E-11
1.9E-10
1.6E-10
2.4E-10
2.4E-10
2.2E-10
9.1E-10
1.5E-13
1.9E-12
4.4E-13
Inhalation
(Risk/pCi)
9.8E-12
7.3E-14
1.5E-10
2.0E-13
3.9E-09
2.6E-08
2.2E-08
3.2E-08
3.2E-08
3.0E-08
1.2E-07
1.1E-13
5.0E-12
1.5E-12 .
External Exposure
(Risk/yr per pCi/g soil)
3.3E-06
4.8E-11
8.6E-06
6.0E-07
3.4E-11
1.6E-07
3.0E-1 1
5.3E-08
2.7E-11
9.2E-07
2.2E-1 1
5.7E-08
2.7E-08
8.4E-12
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
" A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10" Ci.
c For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a *+D* to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
" Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
9 Radioactive half-life: S = Second, M = Minute. D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-5
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuries")
JANUARY 1992
Element
(Atomic Number)
Europium (63)
Fluorine (9)
Francium (87)
Gadolinium (64)
Gallium (31)
Germanium (32)
Gold (79)
Isotope0
Er-171
Eu-152
Eu-154
Eu-155
Eu-156
F-18
Fr-221'
Fr-223f
Gd-153
Gd-159
Ga-67
Ga-72
Ge-71
Au-196
CASRN"
014391-45-8
014683-23-9
015585-10-1
014391-16-3
014280-35-4
013981-56-1
015756-41-9
015756-98-6
014276-65-4
014041-42-0
014119-09-6
013982-22-4
014374-81-3
014914-16-0
Radioactive
Half-life0
7.520E+00
1.360E+01
8.800E+00
4.960E+00
1.520E+01
1.100E+02
4.800E+00
2.180E+00
2.420E+02
1.860E+01
3.260E+00
1.410E+01
1.180E+01
6.180E+00
H
Y
Y
Y
D
M
M
M
D
H
D
H
D
D
ICRP
Lung
Class*
W
W
W
W
W
D
D
D
W
W
W
W
W
Y
Gl
Absorption
Factor (f,)9
3.0E-04
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E+00
1.0E+00
1.0E+00
3.0E-04
3.0E-04
1.0E-03
1.0E-03
1.0E+00
1.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pd)
4.6E-13
2.1E-12
3.0E-12
4.5E-13
2.5E-12
9.8E-14
5.9E-14
1.7E-13
3.1E-13
5.9E-13
2.1E-13
1.3E-12
6.8E-15
3.9E-13
Inhalation
(Risk/pCi)
3.9E-13
1.1E-10
1.4E-10
1.8E-11
1.1E-11
7.1E-14
9.2E-13
4.2E-13
5.8E-12
6.3E-13
3.6E-13
1.2E-12
1.3E-13
8.7E-13
External Exposure
(Risk/yr per pCi/g soil)
9.4E-07
3.6E-06
4.1E-06
5.9E-08
4.8E-06
3.1E-06
6.2E-08
4.1E-08
7.3E-08
8.9E-08
3.3E-07
9.8E-06
2.3E-1 1
1.3E-06
Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10'" Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionuclide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.
4A-6
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuries")
JANUARY 1992
Element
(Atomic Number)
Hotmium (67)
Hydrogen (1)
Indium (49)
Iodine (53)
Isotope0
Au-198
Ho-166
H-3
ln-113m
ln-114
ln-114m
ln-115
ln-115m
1-122
1-123
1-125
1-126
1-129
1-130
CASRN"
010043-49-0
013967-65-2
010028-17-8
014885-78-0(01)
01398-55-0
01398-55-0(m)
014191-71-0
014191-71-0(m)
018287-75-7
015715-08-9
014158-31-7
014158-32-8
015046-84-1
014914-02-4
Radioactive
Half-life*
2.700E+00
2.680E+01
1.230E+01
1.660E+00
7.190E+01
4.950E+01
4.600E+15
4.360E+00
3.620E+00
1.310E+01
6.010E+01
1.290E+01
1.570E+07
1.240E-I-01
D
H
Y
H
S
D
Y
H
M
H
D
D
Y
H
ICRP
Lung
Class'
Y
W
*
W
W
W
W
W
D
D
D
D
D
D
Gl
Absorption
Factor (f,)8
1.0E-01
3.0E-04
1.0E+00
2.0E-02
2.0E-02
2.0E-02
2.0E-02
2.0E-02
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00 .
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.2E-12
1.7E-12
5.4E-14
4.9E-14
5.5E-15
5.4E-12
3.2E-11
1.2E-13
2.5E-14
1.0E-12
7.9E-12
1.5E-11
1.9E-10
9.1E-12
Inhalation
(Risk/pCi)
2.1E-12
2.2E-12
7.8E-14
2.9E-14
1.5E-15
4.2E-11
2.2E-10
9.4E-14
7.9E-15
5.7E-13
5.3E-12
9.8E-12
1.2E-10
5.1E-12
External Exposure
(Risk/yr per pCi/g soil)
1.2E-06
6.5E-08
O.OE+00
7.0E-07
1.0E-07
1.8E-07
O.OE-t-00
3.9E-07
3.0E-06
2.4E-07
2.9E-09
1.3E-06
4.1E-09
7.0E-06
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10" nudear transformations per second. 1 picocurie (pCi) = 10'" Ci.
c For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
e Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year. W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-7
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuriesb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope6
1-131
1-132
1-133
1-134
1-135
lr-190
Indium (77) lr-192
lr-194
Iron (26) Fe-55
Fe-59
Krypton (36) Kr-83m
Kr-85
r\i ^o J
Kr-85m
Kr-87
CASRNd
010043-66-0
014683-16-0
014834-67-4
014914-27-3
014834-68-5
014981-91-0
014694-69-0
014158-35-1
014681-59-5
014596-12-4
013965-98-5(m)
013983-27-2
013983-27-2(m)
014809-68-8
Radioactive
Hall-life8
8.040E+00
2.300E-I-00
2.080E+01
5.260E+01
6.610E+00
1.180E+01
7.400E+01
1.920E+01
2.700E+00
4.460E+01
1.830E+00
1 .070E+01
4.480E+00
7.630E+01
D
H
H
M
H
D
D
H
Y
D
H
V
1
H
M
ICRP
Lung
Class'
D
D
D
0
D
Y
Y
Y
W
W
*
*
•
•
Gl
Absorption
Factor (f,)g
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E-02
1.0E-02
1.0E-02
1.0E-01
1.0E-01
1.0E+00
1 OF+00
1 .VCTW
1.0E+00
I.OE-t-00
Ingestion
(Risk/pCi)
3.6E-1 1
1.0E-12
2.1E-11
2.8E-13
4.2E-12
1.4E-12
1.7E-12
1.6E-12
2.7E-13
2.8E-12
Inhalation
(Risk/pCi)
2.4E-1 1
5.8E-13
1.2E-11
1.6E-13
2.4E-12
4.8E-12
2.7E-1 1
1.8E-12
8.4E-13
9.7E-12
6.2E-17
A 7C.17
•r. I C 1 '
4.9E-16
2.2E-15
External Exposure
(Risk/yr per pCi/g soil)
1.5E-06
7.7E-06
2.0E-06
9.0E-06
5.5E-06
4.2E-06
2.4E-06
2.8E-07
O.OE+00
4.1E-06
3.4E-1 1
7.0E-09
3.4E-07
2.8E-06
0 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10'2 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
9 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.
4A-8
-------
Table 4A: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Picocuriesb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Lanthanum (57)
Lead (82)
Lutetium (71)
Manganese (25)
Isotope0
Kr-88
Kr-89
Kr-90
La-140
Pb-203
Pb-209f
Pb-210t
Pb-210+D
Pb-211r
Pb-212T
Pb-214T
Lu-177
Mn-52
Mn-54
CASRN"
014995-61-0
016316-03-3
015741-13-6
013981-28-7
014687-25-3
014119-30-3
014255-04-0
014255-04-0(+D)
015816-77-0
015092-94-1
015067-28-4
014265-75-9
014092-99-0
013966-31-9
Radioactive
Half-life"
2.840E+00
3.160E+00
3.230E+01
4.020E+01
5.200E+01
3.250E+00
2.230E+01
2.230E+01
3.610E+01
1.060E+01
2.680E-H01
6.710E+00
5.590E+00
3.130E+02
H
M
S
H
H
H
Y
Y
M
H
M
D
D
0
ICRP
Lung
Class'
*
*
•
W
D
D
D
D
0
D
D
Y
W
W
Gl
Absorption
Factor (f,)9
1.0E+00
1.0E+00
1.0E+00
1.0E-03
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
3.0E-04
1.0E-01
1.0E-01
Ingestion
(Risk/pCi)
2.3E-12
3.2E-13
8.5E-14
5.1E-10
6.6E-10
1.8E-13
5.5E-12
1.7E-13
6.2E-13
2.2E-12
1.1E-12
Inhalation
(Risk/pCi)
4.7E-15
2.6E-15
2.4E-15
3.0E-12
2.6E-13
7.0E-14
1.3E-09
4.0E-09
2.8E-12
4.3E-1 1
2.9E-12
1.9E-12
3.7E-12
5.3E-12
External Exposure
(Risk/yr per pCi/g soil)
7.3E-06
6.5E-06
4.2E-06
8.0E-06
5.9E-07
O.OE+00
1.3E-10
1.6E-10
1.6E-07
2.8E-07
6.4E-07
6.7E-08
1.2E-05
2.9E-06
8 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 1010 nuclear transformations per second. 1 picocurie (pCi) = 10" Ci.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
0 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
8 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-9
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Picocuries")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Mercury (80)
Molybdenum (42)
Neodymium (60)
Neptunium (93)
Nickel (28)
Isotope0
Mn-56
Hg-197
Hg-203
Mo-99
Nd-147
Nd-149
Np-236
Np-237t
Np-237+D
Np-238
Np-239r
Np-240
Np-240m
Ni-59
CASRN"
014681-52-8
013981-51-6
013982-78-0
014119-15-4
014269-74-0
015749-81-2
015700-36-4
013994-20-2
013994-20-2(+D)
015766-25-3
013968-59-7
015690-84-3
015690-84-3(m)
014336-70-0
Radioactive
Half-life"
2.580E+00
6.410E+01
4.660E+01
6.600E+01
1.100E+01
1.730E+00
1.150E+05
2.140E+06
2.140E+06
2.120E+00
2.360E+00
6.500E-f01
7.400E-t-00
7.500E+04
H
H
D
H
D
H
Y
Y
Y
0
D
M
M
Y
ICRP
Lung
Class'
W
W
W
Y
Y
Y
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)8
1.0E-01
2.0E-02
2.0E-02
8.0E-01
3.0E-04
3.0E-04
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
5.0E-02
Ingestion
(Risk/pCi)
4.0E-13
2.7E-13
6.6E-13
1.5E-12
1.3E-12
1.9E-13
2.3E-13
2.2E-10
2.2E-10
1.1E-12
9.4E-13
1.3E-13
2.9E-14
9.1E-14
Inhalation
(Risk/pCi)
2.8E-13
4.5E-13
4.8E-12
2.6E-12
5.5E-12
1.6E-13
3.9E-12
2.9E-08
2.9E-08
3.3E-12
1.5E-12
6.5E-14
9.0E-15
7.0E-13
External Exposure
(Risk/yr per pCi/g soil)
6.1E-06
5.5E-08
5.7E-07
4.9E-07
3.0E-07
9.8E-07
8.9E-08
7.8E-09
4.3E-07
1.7E-06
2.3E-07
3.2E-06
9.3E-07
O.OE+00
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to tfie User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10" Ci.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a'+ D' to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
" Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
e Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
8 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) Inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-10
-------
Table 4A: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Picocuries")
JANUARY 1982
Element
(Atomic Number) Isotope0
Ni-63
Ni-65
Niobium (41) Nb-93m
Nb-94
Nb-95
Nb-95m
Nb-97
Nb-97m
Osmium (76) Os-185
Os-191
Os-191m
Os-193
Palladium (46) Pd-100
Pd-101
CASRN"
013981-37-8
014833-49-9
007440-03-1 (m)
014681-63-1
013967-76-5
013967-76-5(m)
018496-04-3
018496-04-3(m)
015766-50-4
014119-24-5
014119-24-5(m)
016057-77-5
015690-69-4
015749-54-9
Radioactive
Half-life0
1.000E+02
2.520E+00
1.460E+01
2.030E+04
3.510E+01
8.660E+01
7.210E+01
6.000E+01
9.360E+01
1.540E+01
1.300E+01
3.000E+01
3.640E+00
8.480E+00
Y
H
Y
Y
D
H
M
S
D
D
H
H
D
H
ICRP
Lung
Class*
W
W
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Gl
Absorption
Factor (f,)9
5.0E-02
5.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
5.0E-03
5.0E-03
Ingestion
(Risk/pCi)
2.4E-13
2.6E-13
1.5E-13
2.1E-12
6.5E-13
6.6E-13
1.2E-13
2.4E-15
6.3E-13
6.7E-13
1.2E-13
9.6E-13
1.0E-12
1.2E-13
Inhalation
(Risk/pCi)
1.8E-12
1.9E-13
1.9E-11
2.1E-10
5.1E-12
1.6E-12
6.9E-14
1.1E-15
8.9E-12
3.6E-12
2.1E-13
1.2E-12
2.3E-12
1.1E-13
External Exposure
(Risk/yr per pCi/g soil)
O.OE+00
1.9E-06
5.3E-1 1
5.4E-06
2.6E-06
8.1E-08
2.2E-06
2.5E-06
2.2E-06
8.5E-08
3.4E-09
1.7E-07
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci). the customary unit of activity, is equal to 3.7 x 10" nudear transformations per second. 1 picocurie (pCi) = 10'<: Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a '+0* to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day,' = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-11
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Picocuries")
JANUARY 1982
Element
(Atomic Number) Isotope0
Pd-103
Pd-107
Pd-109
Phosphorus (15) P-32
P-33
Platinum (78) Pt-191
Pt-193
Pt-193m
Pt-197
Pt-197m
Plutonium (94) Pu-236
Pu-238
Pu-239
Pu-240
CASRN"
014967-68-1
017637-99-9
014981-64-7
014596-37-3
015749-66-3
015706-36-2
015735-70-3
015735-70-3(m)
015735-74-7
015735-74-7(01)
015411-92-4
013981-16-3
015117-48-3
014119-33-6
Radioactive
Half-life*
1.700E+01
6.500E+06
1.350E+01
1.430E+01
2.540E+01
2.710E+00
5.000E+01
4.330E+00
1.830E+01
9.440E+01
2.850E+00
8.780E+01
2.410E+04
6.570E+03
D
Y
H
0
D
D
Y
D
H
M
Y
Y
Y
Y
ICRP
Lung
Class'
Y
Y
Y
D
D
D
D
D
D
0
Y
Y
Y
Y
Gl
Absorption
Factor (f,)8
5.0E-03
5.0E-03
5.0E-03
8.0E-01
8.0E-01
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-03
1.0E-03
1.0E-03
1.0E-03
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
2.2E-13
4.4E-14
7.9E-13
3.5E-12
5.6E-13
3.8E-13
3.5E-14
5.3E-13
4.9E-13
1.2E-13
5.0E-11
2.2E-10
2.3E-10
2.3E-10
Inhalation
(Risk/pCi)
1.4E-12
6.4E-12
8.1E-13
3.0E-12
4.6E-13
3.0E-13
8.2E-14
4.0E-13
3.2E-13
8.7E-14
2.4E-08
3.9E-08
3.8E-08
3.8E-08
External Exposure
(Risk/yr per pCi/g soil)
7.3E-10
O.OE+00
2.2E-09
O.OE+00
O.OE+00
6.3E-07
O.OE+00
7.6E-09
3.1E-08
1.6E-07
3.4E-11
2.8E-1 1
1.7E-11
2.7E-11
Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
6 A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10" Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a %-D" to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
a Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-12
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuriesb)
JANUARY 1992
Element
(Atomic Number)
Polonium (84)
Potassium (19)
Praseodymium (59)
Isotope0
Pu-241
Pu-242
Pu-243
Pu-244
Po-210f
Po-212f
Po-213f
Po-214f
Po-215r
Po-216'
Po-218'
K-40
K-42
Pr-142
CASRNd
014119-32-5
013982-10-0
015706-37-3
014119-34-7
013981-52-7
015389-34-1
015756-57-7
015735-67-8
015706-52-2
015756-58-8
015422-24-9
013966-00-2
014378-21-3
014191-64-1
Radioactive
Half-life"
1.440E+01
3.760E+05
4.960E+00
8.260E-f07
1.380E-f02
2.980E-07
4.200E-06
1.640E-04
1.780E-03
1.460E-01
3.050E+00
1.280E-f09
1.240E+01
1.910E+01
Y
Y
H
Y
D
S
S
S
S
S
M
Y
H
H
ICRP
Lung
Class'
Y
Y
Y
Y
W
W
W
W
W
W
W
D
D
Y
Gl
Absorption
Factor (f,)9
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E+00
1.0E+00
3.0E-04
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
3.6E-12
2.2E-10
1.1E-13
2.2E-10
1.5E-10
2.2E-23
3.2E-22
1.0E-20
2.8E-19
3.0E-17
2.8E-14
1.1E-11
8.9E-13
1.6E-12
Inhalation
(Risk/pCi)
2.3E-10
3.6E-08
1.0E-13
3.6E-08
2.6E-09
6.1E-22
8.0E-21
2.8E-19
5.7E-18
4.8E-16
5.8E-13
7.6E-12
1.2E-12
1.8E-12
External Exposure
(Risk/yr per pCi/g soil)
O.OE+00
2.3E-1 1
1.8E-08
1.9E-11
2.9E-1 1
O.OE+00
1.0E-10
2.8E-10
4.6E-10
5.0E-11
O.OE-fOO
5.4E-07
9.6E-07
2.1E-07
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 1012 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
9 Radioactive half-life: S = Second, M = Minute, 0 = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
8 Gl absorption factors are the fractional amount of the radionuclide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-13
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picoburiesb)
JANUARY 1992
Element
(Atomic Number)
Promethium(61)
Protactinium (91)
Radium (88)
Isotope0
Pr-143
Pr-144
Pr-144m
Pm-147
Pm-148
Pm-148m
Pm-149
Pa-231T
Pa-233f
Pa-234
Pa-234mf
Ra-223t
Ra-224f
Ra-225f
CASRN"
014981-79-4
014119-05-2
014119-05-2(m)
014380-75-7
014683-19-3
01 4683-1 9-3(m)
015765-31-8
014331-85-2
013981-14-1
015100-28-4
015100-28-4(m)
015623-45-7
013233-32-4
013981-53-8
Radioactive
Half-life0
1.360E+01
1.730E+01
7.200E+00
2.620E+00
5.370E+00
4.130E+01
5.310E+01
3.730E+04
2.700E+01
6.700E+00
1.170E+00
1.140E+01
3.620E+00
1.480E+01
D
M
M
Y
D
D
H
Y
D
H
M
D
D
D
ICRP
Lung
Class'
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
Gl
Absorption
Factor (f,)9
3.0E-04
3.0E-04
3.0E-04
3.0E-04
3.0E-04
3.0E-04
3.0E-04
1.0E-03
1.0E-03
1.0E-03
1.0E-03
2.0E-01
2.0E-01
2.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.4E-12
9.5E-14
3.7E-14
3.1E-13
3.1E-12
2.5E-12
1.2E-12
9.2E-11
1.0E-12
6.8E-13
5.8E-15
6.4E-11
3.8E-1 1
5.1E-11
Inhalation
(Risk/pCi)
7.0E-12
3.6E-14
1.6E-14
3.0E-1 1
7.9E-12
4.8E-1 1
1.9E-12
3.6E-08
8.6E-12
5.4E-13
1.6E-15
3.1E-09
1.2E-09
1.5E-09
External Exposure
(Risk/yr per pCi/g soil)
3.0E-14
1.2E-07
2.1E-09
6.0E-12
1.9E-06
6.5E-06
3.3E-08
2.6E-08
4.2E-07
5.9E-06
3.6E-08
2.3E-07
2.3E-08
1.9E-09
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10" nuclear transformations per second. 1 picocurie (pCi) = 10'12 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionudide only, except when marked with a %-D" to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute. D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
8 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-14
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuries")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope6
Ra-226*
Ra-226+D
Ra-228*
Ra-228+D
Radon (86) Rn-219'
Rn-220'
Rrt-222T
Rn-222+D
Rhodium (45) Rh-103m
Rh-105
Rh-105m
Rh-106
Rubidium (37) Rb-82
Rb-86
CASRN"
013982-63-3
013982-63-3(-fD)
015262-20-1
01 5262-20-1 (+D)
014835-02-0
022481-48-7
014859-67-7
014859-67-7(+D)
007440-16-6(m)
014913-8*4
014913^89-4(m)
013967-48-1
014391-63-0
014932-53-7
Radioactive
Half-life0
1.600E+03
1.600E+03
5.750E-1-00
5.750E+00
3.960E+00
5.560E+01
3.820E+00
3.820E+00
5.610E+01
3.540E+01
4.500E+01
2.990E+01
1.250E+00
1.870E+01
Y
Y
Y
Y
S
S
D
D
M
H
S
S
M
D
ICRP
Lung
Class'
W
W
W
W
*
•
*
*
Y
Y
Y
Y
D
D
Gl
Absorption
Factor (f,)9
2.0E-01
2.0E-01
2.0E-01
2.0E-01
1.0E+00
1.0E-fOO
1.0E+00
1.0E+00
5.0E-02
5.0E-02
5.0E-02
5.0E-02
1.0E+00
1.0E+00
Ingestion
(Risk/pCi)
1.2E-10
1.2E-10
1.0E-10
1.0E-10
1.4E-12
1.7E-12
6.9E-15
4.3E-13
6.2E-16
4.4E-15
1.2E-14
5.9E-12
Inhalation
(Risk/pCi)
3.0E-09
3.0E-09
6.6E-10
6.9E-10
4.6E-14
1.2E-13
7.3E-13
7.7E-12
3.9E-15
5.9E-13
3.4E-16
1.2E-15
3.5E-15
4.5E-12
External Exposure
(Risk/yr per pCi/g soil)
1.2E-08
6.0E-06
O.OE+00
2.9E-06
1.6E-07
1.7E-09
1.2E-09
5.9E-06
7.9E-11
2.2E-07
2.2E-08
6.7E-07
3.5E-06
3.3E-07
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10" nudear transformations per second. 1 picocurie (pCi) = 10 '2 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a %D" to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each -chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 *
Lung dearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestibn slope factors. See the User's Guide for instructions.
4A-15
-------
Table 4A: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Picocuries")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Ruthenium (44)
Samarium (62)
Scandium (21)
Selenium (34)
Isotope0
Rl>87
Rb-88
Rb-89
Ru-97
Ru-103
Ru-105
Ru-106
Sm-147
Sm-151
Sm-153
Sc-46
Sc-47
Sc-48
Se-75
CASRNd
013982-13-3
014928-36-0
. 014191-65-2
015758-35-7
013968-53-1
014331-9&4
013967-48-1
014392-33-7
015715-94-3
015766-00-4
013967-634
014391-96-9
014391-86-7
014265-71-5
Radioactive
Half-life0
4.730E+10
1.780E+01
1.540E+01
2.900E+00
3.940E+01
4.440E+00
3.680E+02
1.060E+11
9.000E+01
4.670E+01
8.380E+01
3.420E+00
4.370E+01
1.200E-f02
Y
M
M
D
D
H
D
Y
Y
H
D
D
H
D
ICRP
Lung
Class'
D
D
D
Y
Y
Y
Y
W
W
W
Y
Y
Y
W
Gl
Absorption
Factor (f,)9
1.0E+00
1.0E+00
1.0E+00
5.0E-02
5.0E-02
5.0E-02
5.0E-02
3.0E-04
3.0E-04
3.0E-04
1.0E-04
1.0E-04
1.0E-04
8.0E-01
Ingestion
(Risk/pCi)
3.4E-12
1.7E-13
9.3E-14
1.7E-13
9.0E-13
3.7E-13
9.5E-12
1.6E-11
1.1E-13
8.7E-13
1.6E-12
6.4E-13
1.9E-12
5.8E-12
Inhalation
(Risk/pCi)
2.4E-12
7.9E-14
3.9E-14
2.6E-13
8.4E-12
3.3E-13
•4.4E-10
7.2E-09
8.7E-12
1.3E-12
2.7E-11
1.2E-12
2.3E-12
6.0E-12
External Exposure
(Risk/yr per pCi/g soil)
O.OE+00
2.4E-06
7.4E-06
4.2E-07
1.5E-06
2.6E-06
O.OE+00
O.OE-fOO
4.0E-13
4.6E-08
6.9E-06
2.3E-07
1.2E-05
8.1E-07
3
Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10'12 Ci.
c For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D* to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a 'f are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For ttiose radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionuclide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4 A- 16
-------
Table 4A: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Picocuriesb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Silicon (14)
Silver (47)
Sodium (11)
Strontium (38)
Isotope0
Si-31
Ag-105
Ag-108
Ag-108m
Ag-109m
Ag-110
Ag-110m
Ag-111
Na-22
Na-24
Sr-82
Sr-85
Sr-85m
Sr-89
CASRN"
014276-49-4
014928-14-4
014391-65-2
014391-€5-2(m)
014378-38-2(m)
014391-76-5
014391-76-5(m)
0157690-04-0
013966-32-0
013982-04-2
014809-50-8
013967-73-2
013967-73-2(m)
014158-27-1
Radioactive
Half-life6
1.570E+02
4.130E+01
2.370E+00
1.270E+02
3.960E+01
2.460E-.-01
2.500E+02
7.460E+00
2.600E+00
1.500E+01
2.500E+01
6.480E+01
6.770E+01
5.060E+01
M
0
M
Y
S
S
D
D
Y
H
D
D
M
D
ICRP
Lung
Class'
W
Y
Y
Y
Y
Y
Y
Y
D
D
D
D
0
D
Gl
Absorption
Factor (f,)9
1.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
1.0E+00
1.0E+00
3.0E-01
3.0E-01
3.0E-01
3.0E-01
Ingestion
(Risk/pCi)
2.2E-13
7.3E-13
8.5E-15
3.5E-12
3.3E-16
3.0E-15
4.7E-12
1.6E-12
6.8E-12
1.0E-12
7.5E-12
7.7E-13
1.2E-14
3.0E-12
Inhalation
(Risk/pCi)
1.7E-13
4.0E-12
2.4E-15
1.5E-10
8.9E-17
8.1E-16
6.9E-1 1
4.8E-12
4.8E-12
9.6E-13
6.9E-12
1.0E-12
6.1E-15
2.9E-12
External Exposure
(Risk/yr per pCi/g soil)
3.0E-09
5.1E-08
5.0E-06
1.3E-09
1.0E-07
9.3E-06
7.7E-08
7.2E-06
1.6E-05
1.3E-10
1.4E-06
4.8E-07
4.7E-10
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
" A curie (Ci). the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 1012 Ci.
c For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a m+D" to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year. W = Week, D = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-17
-------
Table 4A: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Picocuriesb)
JANUARY 1992
Element
(Atomic Number) Isotope0
Sr-90t
Sr-90+D
Sr-91
Sr-92
Sulfur (16) S-35
Tantalum (73) Ta-182
Technetium (43) Tc-95
Tc-95m
Tc-96
Tc-96m
Tc-97
Tc-97m
Tc-99
Tc-99m
CASRNd
010098-97-2
010098-97-2(-fD)
014331-91-0
014928-29-1
015117-53-0
013982-00-8
014809-56-4
014809-56-4(m)
014808-44-7
014808-44-7(m)
015759-35-0
015759-35-0(m)
014133-76-7
014133-76-7(m)
Radioactive
Half-life*
2.860E-I-01
2.860E+01
9.500E+00
2.710E+00
8.740E+01
1.150E+02
2.000E+01
6.100E+01
4.280E+00
5.150E+01
2.600E+06
8.900E+01
2.130E+05
6.020E+00
Y
Y
H
H
D
D
H
D
D
M
Y
D
Y
H
ICRP
Lung
Class'
D
D
D
D
D
Y
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)9
3.0E-01
3.0E-01
3.0E-01
3.0E-01
8.0E-01
1.0E-03
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
3.3E-1 1
3.6E-11
8.5E-13
5.7E-13
2.2E-13
1.7E-12
5.6E-14
1.8E-12
1.8E-12
2.3E-14
1.5E-13
1.1E-12
1.3E-12
5.0E-14
Inhalation
(Risk/pCi)
5.6E-11
6.2E-11
6.9E-13
4.5E-13
1.9E-13
4.3E-11
2.3E-14
4.0E-12
2.1E-12
2.1E-14
9.8E-13
5.0E-12
8.3E-12
£7E-14
External Exposure
(Risk/yr per pCi/g soil)
O.OE+00
O.OE+00
2.4E-06
4.6E-06
O.OE+00
4.1E-06
2.4E-06
1.9E-06
8.3E-06
7.0E-08
3.5E-10
3.7E-10
6.0E-13
2.3E-07
" Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
6 A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10" Ci.
c For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a %-D' to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
a Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
8 Gl absorption factors are the fractional amount of the radionuclide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-18
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuriesb)
JANUARY 1992
Element
(Atomic Number) Isotope0
Tellurium (52) Te-125m
Te-127
Te-127m
Te-129
Te-129m
Te-131
Te-131m
Te-132
Terbium (65) Tb-158
Tb-160
Thallium (81) TI-202
TI-204
T\-20r
11-208*
CASRN"
014390-73-9(m)
013981-49-2
013981-49-2(m)
014269-71-7
014269-71-7(m)
014683-12-6
014683-12-6(m)
014234-28-7
015759-55-4
013981-29-8
015720-57-7
013968-51-9
014133-67-6
014913-50-9
Radioactive
Half-life0
5.800E+01
9.350E+00
1.090E+02
6.960E+01
3.360E+01
2.500E+01
3.000E+01
7.820E+01
1.500E-t-02
7.230E+01
1.220E+01
3.780E+00
4.770E+00
3.050E+00
D
H
D
M
D
M
H
H
Y
D
D
Y
M
M
ICRP
Lung
Class'
W
W
W
W
W
W
W
W
W
W
D
D
D
D
Gl
Absorption
Factor (f,)B
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
3.0E-04
3.0E-04
1.0E+00
1.0E+00
1.0E+00
1.0E+00
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
8.5E-13
2.3E-13
2.2E-12
1.1E-13
3.2E-12
2.8E-13
3.8E-12
3.0E-12
1.2E-12
1.8E-12
8.4E-13
1.7E-12
1.3E-14
1.8E-14
Inhalation
(Risk/pCi)
5.4E-12
2.3E-13
1.6E-11
6.8E-14
2.0E-1 1
1.4E-13
5.4E-12
5.3E-12
9.4E-1 1
1.9E-11
6.0E-13
1.3E-12
4.5E-15
5.0E-15
External Exposure
(Risk/yr per pCi/g soil)
2.6E-09
1.4E-08
8.4E-10
1.3E-07
6.3E-08
1.2E-06
4.7E-06
4.0E-07
3.6E-06
1.3E-06
8.7E-10
7.5E-09
1.3E-05
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
6 A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10'12 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D* to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
" Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
f Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-19
-------
Table 4A: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Picocuriesb)
JANUARY 1982
Element
(Atomic Number) Isotope0
11-209*
Thorium (90) 171-227*
111-228'
Th-228+D
Th-229f
Th-229+D
111-230'
Th-231f
Th-2321
Th-234*
Thulium (69) Tm-1 70
Tm-171
Tin (50) Sn-113
Sn-121
CASRNd
015690-73-0
015623-47-9
014274-82-9
014274-82-9(+D)
015594-54-4
015594-54-4(+D)
014269-63-7
014932-40-2
2007440-29-1
015065-10-8
013981-30-1
014333-45-0
013966-06-8
014683-06-8
Radioactive
Half-life*
2.200E+00
1.870E+01
1.910E+00
1.910E+00
7.340E+03
7.340E+03
7.700E+04
2.550E+01
1.410E+10
2.410E+01
1.290E+02
1.920E+00
1.150E+02
2.710E+01
M
D
Y
Y
Y
Y
Y
H
Y
D
D
Y
D
H
ICRP
Lung
Class'
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
W
Gl
Absorption
Factor (f,)g
1.0E+00
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
3.0E-04
3.0E-04
2.0E-02
2.0E-02
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/pCi)
1.4E-14
4.5E-12
1.1E-11
5.5E-11
2.1E-11
8.9E-11
1.3E-11
4.0E-13
1.2E-11
4.0E-12
1.5E-12
1.2E-13
8.7E-13
2.7E-13
Inhalation
(Risk/pCi)
4.3E-15
4.9E-09
7.7E-08
7.8E-08
7.3E-08
7.7E-08
2.9E-08
4.9E-13
2.8E-08
3.2E-11
2.1E-11
3.1E-12
9.4E-12
3.2E-13
External Exposure
(Risk/yr per pCi/g soil)
6.9E-06
1.6E-07
5.5E-10
5.6E-06
5.8E-08
6.8E-07
5.4E-1 1
2.3E-09
2.6E-11
3.5E-09
3.8E-09
3.3E-10
3.3E-09
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nuclear transformations per second. 1 picocurie (pCi) = 10'12 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a '+D' to indicate that the
risks from radioactive decay chain products are also included. Radionudides designated with a "f" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-20
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Picocuries")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Sn-121m
Sn-125
Sn-126
Tungsten (74) W-181
W-185
W-187
Uranium (92) U-232
U-233
U-234'
U-235'
U-235+D
U-236
U-237
11-238*
CASRN"
014683-06-8(m)
014683-08-0
015832-50-5
015749-46-9
014932-41-3
014983-48-3
014158-29-3
013968-55-3
013966-29-5
015117-96-1
015117-96-1(+D)
013982-70-2
014269-75-1
007440-61-1
Radioactive
Half-life0
5.550E+01
9.640E+00
1.000E+05
1.210E+02
7.510E+01
2.380E+01
7.200E+01
1.590E+05
2.450E-f05
7.040E+08
7.040E+08
2.340E+07
6.750E+00
4.470E+09
Y
D
Y
D
D
H
Y
Y
Y
Y
Y
Y
D
Y
ICRP
Lung
Class1
W
W
W
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Gl
Absorption
Factor (f,)fl
2.0E-02
2.0E-02
2.0E-02
3.0E-01
3.0E-01
3.0E-01
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
Ingestion
(Risk/pCi)
5.4E-13
3.6E-12
5.6E-12
8.3E-14
4.7E-13
6.3E-13
3.7E-11
1.6E-11
1.6E-11
1.6E-11
1.6E-11
1.5E-11
8.9E-13
1.6E-11
Inhalation
(Risk/pCi)
9.3E-12
1.2E-11
7.7E-1 1
6.4E-14
3.0E-13
3.9E-13
6.0E-08
2.7E-08
2.6E-08
2.5E-08
2.5E-08
2.5E-08
2.6E-12
2.4E-08
External Exposure
(Risk/yr per pCi/g soil)
1.1E-06
3.3E-08
2.2E-08
4.7E-1 1
1.5E-06
4.6E-11
4.2E-11
3.0E-1 1
2.4E-07
2.4E-07
2.4E-11
1.3E-07
2.1E-11
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10'" Ci.
c For each radionuclide listed, corresponding slope /actors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
9 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year. W = Week, D = Day. * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e.. multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-21
-------
Table 4A: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Picocuries")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
U-238+D
U-240
Vanadium (23) V-48
Xenon (54) Xe-122
Xe-123
Xe-125
Xe-127
Xe-129m
Xe-131m
Xe-133
Xe-133m
Xe-135
Xe-135m
Xe-137
CASRNd
007440-«1-1(+D)
015687-53-3
014331-97-6
015151-09-4
015700-10-4
013994-18-8
013994-19-9
013965-99-6(m)
014683-11-5(01)
014932-42-4
014932-42-4(m)
014995-62-1
014995-62-1(01)
014835-21-3
ICRP Gl
Radioactive Lung Absorption Ingestion
Half-life* Class* Factor (f,)9 (Risk/pCi)
4.470E+09
1.410E+01
1.600E+01
2.010E+01
2.140E+00
1.680E+01
3.640E+01
8.890E+00
1.180E+01
5.250E+00
2.190E+00
9.110E+00
1.540E+01
3.830E+00
Y Y 5.0E-02 2.8E-11
H Y 5.0E-02 1.2E-12
D W 1.0E-02 2.2E-12
H* 1 OF+QO
H* 1 nFinn
H* 1 OF i on
D* 1 nF inn
D* 1 OFj-OO
H* 1 OFifJO
M* 1 nF i nn
M* 1 nF ion
Inhalation
(Risk/pCi)
5.2E-08
1.2E-12
7.6E-12
3.3E-15
7.4E-16
4.2E-16
4.0E-16
6.0E-16
4.3E-16
4.3E-16
5.4E-16
8.0E-16
2.1E-16
1.8E-15
External Exposure
(Risk/yr per pCi/g soil)
3.6E-08
1.5E-10
9.9E-06
8.4E-08
1.7E-06
4.7E-07
5.0E-07
1.3E-08
4.5E-09
2.3E-08
3.3E-08
6.2E-07
1.3E-06
6.0E-07
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 10'° nudear transformations per second. 1 picocurie (pCi) = 10'12 Ci.
0 For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided tor reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-22
-------
Table 4A: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Picocuries")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake Of Exposure
Element
(Atomic Number)
Yttrium (39)
Zinc (30)
Zirconium (40)
Isotope0
Xe-138
Y-90'
Y-91
Y-91m
Y-92
Y-93
Zn-65
Zn-69
Zn-69m
Zr-93
Zr-95
Zr-97
CASRNd
015751-81-2
010098-91-6
014234-24-3
014234-24-3(m)
015751-594
014981-70-5
013982-39-3
013982-23-5
013982-23-5(m)
015751-77-6
013967-71-0
014928-30-4
Radioactive
Half-life0
1.410E+01
6.410E+01
5.850E+01
4.970E+01
3.540E+00
1.010E+01
2.440E+02
5.560E+01
1.380E+01
1.530E+06
6.400E-t-01
1.690E+01
M
H
D
M
H
H
D
M
H
Y
0
H
ICRP
Lung
Class'
*
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
Gl
Absorption
Factor (f,)g
1.0E+00
1.0E-04
1.0E-04
1.0E-04
1.0E-04
1.0E-04
5.0E-01
5.0E-01
5.0E-01
2.0E-03
2.0E-03
2.0E-03
Ingestion
(Risk/pCi)
3.2E-12
2.8E-12
2.2E-14
7.1E-13
1.4E-12
8.5E-12
5.6E-14
4.3E-13
1.7E-13
9.9E-13
2.4E-12
Inhalation
(Risk/pCi)
2.8E-15
5.5E-12
4.8E-1 1
3.5E-14
5.8E-13
1.4E-12
1.6E-11
3.2E-14
5.7E-13
6.5E-12
1.0E-11
2.5E-12
External Exposure
(Risk/yr per pCi/g soil)
4.0E-06
O.OE+00
1.2E-08
1.7E-06
8.6E-07
3.0E-07
2.0E-06
1.8E-11
1.3E-06
O.OE+00
2.5E-06
6.1E-07
8 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A curie (Ci), the customary unit of activity, is equal to 3.7 x 1010 nudear transformations per second. 1 picocurie (pCi) = 1012 Ci.
c For each radionuclide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+0" to indicate that the
risks from radioactive decay chain products are also induded. Radionudides designated with a T are members of a decay chain.
0 Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, 0 = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionuclide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4A-23
-------
Table 4B: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Becquerelsb)
JANUARY 1992
Element
(Atomic Number) Isotope6
Actinium (89) Ac-225'
Ac-aa^
Ac-227+D
Ac-228
Amerlcium (95) Am-241t
Am-242
Am-242m
Am-243*
Am-243+D
Antimony (51) Sb-122
Sb-124
Sb-125
Sb-126
Sb-126m
CASRN"
014265-85-1
014952-40-0
014952-40-0(+D)
014331-83-0
014596-10-2
013981-54-9
013981-54-9(m)
014993-75-0
014993-75-0(+D)
014374-79-9
014683-10-4
014234-35-6
015756-32-8
015756-32-8(m)
Radioactive
Half-life*
1.000E+01
2.180E+01
2.180E+01
6.130E+00
4.320E+02
1.600E+01
1.520E+02
7.380E+03
7.380E+03
2.700E+00
6.020E+01
2.770E+00
1.240E+01
1.900E+01
D
Y
Y
H
Y
H
Y
Y
Y
D
D
Y
D
M
ICRP
Lung
Class*
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)fl
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
4.6E-10
7.6E-09
9.5E-09
1.4E-11
6.5E-09
9.7E-12
6.2E-09
6.5E-09
6.5E-09
5.4E-1 1
7.8E-11
2.3E-11
7.6E-1 1
1.9E-12
Inhalation
(Risk/Bq)
6.5E-08
2.2E-06
2.4E-06
7.0E-10
8.6E-07
3.2E-10
7.6E-07
8.6E-07
8.6E-07
9.2E-1 1
5.9E-10
3.0E-10
2.4E-10
7.0E-13
External Exposure
(Risk/yr per Bq/g soil)
2.1E-07
7.0E-10
2.3E-05
7.8E-05
1.3E-07
1.6E-07
3.2E-09
6.5E-07
6.8E-06
3.8E-05
1.8E-04
3.2E-05
2.5E-04
1.4E-04
8 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
" A becquerel (Bq). the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a *+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+0), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions.
4B-1
-------
Table 4B: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Becquerelsb)
JANUARY 1992
Element
(Atomic Number)
Argon (18)
Astatine (85)
Barium (56)
Beryllium (4)
Bismuth (83)
Isotope"
Sb-127
Sb-129
Ar-41
At-ai^
Ba-131
Ba-133
Ba-133m
Ba-137mf
Ba-139
Ba-140
Be-7
Bi-206
Bi-207
Bi-210T
CASRN1*
013968-50-8
014331-88-5
014163-25-8
017239-90-6
014914-75-1
013981-41-4
013981-41-4(m)
013981-97-0(m)
014378-25-7
014798-0&4
013966-02-4
015776-19-9
013982-38-2
014331-79-4
Radioactive
Half-life*
3.850E+00
4.400E+00
1.830E+00
3.230E-02
1.180E+01
1.050E+01
3.890E+01
2.550E+00
8.310E+01
1.280E+01
5.340E+01
6.240E+00
3.340E+01
5.010E+00
D
H
H
S
D
Y
H
M
M
D
D
D
Y
D
ICRP
Lung
Class'
W
W
*
D
D
D
D
D
D
D
Y
W
W
W
Gl
Absorption
Factor (f,)9
1.0E-01
1.0E-01
1.0E+00
1.0E+00
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
5.0E-03
5.0E-02
5.0E-02
5.0E-02
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
5.4E-1 1
1.6E-11
1.2E-16
1.3E-11
3.2E-11
1.7E-11
6.5E-14
5.7E-12
7.3E-11
8.1E-13
5.9E-11
3.8E-11
4.3E-1 1
Inhalation
(Risk/Bq)
1.1E-10
1.4E-11
1.6E-14
1.5E-15
9.7E-12
9.7E-11
9.5E-12
1.6E-14
4.1E-12
5.4E-11
7.3E-12
1.2E-10
4.9E-10
2.2E-09
External Exposure
(Risk/yr per Bq/g soil)
5.7E-05
1.3E-04
1.2E-04
2.1E-08
3.2E-05
2.3E-05
2.6E-06
5.4E-05
2.1E-06
1.5E-05
4.1E-06
3.0E-04
1.3E-04
O.OE+00
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a VD" to indicate that the risks
from radioactive decay chain products are also inducted. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided tor reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-2
-------
Table 4B: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Bromine (35)
Cadmium (20)
Calcium (20)
Carbon (6)
Cerium (58)
Isotope0
Bi-211T
Bi-212t
Bi-213f
Bi-214f
Br-82
Cd-109
Cd-115
Cd-115m
Ca-45
Ca-47
C-11
C-14
C-15
Ce-141
CASRN"
015229-37-5
014913-49-6
015776-20-2
014733-03-0
014686-69-2
014109-32-1
014336-68-6
014336-68-6(m)
013966-05-7
001439-99-2
014333-33-6
014762-75-5
015929-23-4
013967-74-3
Radioactive
Half-life0
2.130E+00
6.055E+01
4.570E+01
1.990E+01
3.530E+01
4.640E+02
5.350E+01
4.460E+01
1.630E+02
4.540E+00
2.050E+01
5.730E+03
2.450E+00
3.250E+01
M
M
M
M
H
D
H
D
D
D
M
Y
S
D
ICRP
Lung
Class'
W
W
W
W
D
Y
Y
Y
W
W
D
*
D
Y
Gl
Absorption
Factor (f,)g
5.0E-02
5.0E-02
5.0E-02
5.0E-02
1.0E+00
5.0E-02
5.0E-02
5.0E-02
3.0E-01
3.0E-01
1.0E+00
LOE-t-00
1.0E-I-00
3.0E-04
Ingestion
(Risk/Bq)
3.3E-13
8.4E-12
6.2E-12
3.5E-12
3.0E-11
2.1E-10
4.6E-1 1
1.4E-10
2.7E-11
5.4E-11
1.3E-12
2.4E-1 1
2.2E-14
2.2E-11
Inhalation
(Risk/Bq)
5.2E-12
1.8E-10
8.1E-12
5.7E-11
2.4E-1 1
1.8E-09
7.0E-1 1
1.1E-09
1.4E-10
1.2E-10
5.7E-13
1.7E-13
5.7E-15
2.3E-10
External Exposure
(Risk/yr per Bq/g soil)
3.6E-06
1.6E-05
1.1E-05
1.4E-04
2.4E-04
2.0E-08
1.7E-05
2.0E-06
1.6E-16
9.7E-05
8.6E-05
O.OE+00
3.5E-06
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a *+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-3
-------
Table 4B: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Ce-143
Ce-144
Cesium (55) Cs-131
Cs-134
Cs-134m
Cs-135
Cs-136
08-137*
Cs-137+D
Cs-138
Chlorine (17) CI-36
CI-38
Chromium (24) Cr-51
Cobalt (27) Co-57
CASRNd
014119-19-8
014762-78-8
014914-76-2
013967-70-9
013967-70-9(m)
015726-30-4
014234-29-8
010045-97-3
010045-97-3(+D)
015758-29-9
013981-43-6
014158-34-0
014392-02-0
013981-50-5
Radioactive
Half-life0
3.300E+01
2.840E+02
9.690E-I-00
2.060E+00
2.900E+00
2.300E+06
1.320E+01
3.020E+01
3.020E+01
3.220E+01
3.010E+05
3.720E+01
2.770E+01
2.710E+02
H
D
D
Y
H
Y
D
Y
Y
M
Y
M
D
D
ICRP
Lung
Class'
Y
Y
D
D
D
D
D
D
D
D
D
D
Y
Y
Gl
Absorption
Factor (f,)a
3.0E-04
3.0E-04
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E-01
3.0E-01
Ingestion
(Risk/Bq)
3.5E-1 1
1.6E-10
3.8E-12
1.1E-09
1.1E-12
1.1E-10
1.8E-10
7.6E-10
7.6E-10
5.1E-12
4.9E-11
6.2E-12
1.2E-12
1.6E-11
Inhalation
(Risk/Bq)
5.9E-11
9.2E-09
2.7E-12
7.6E-10
1.1E-12
7.3E-11
1.2E-10
5.1E-10
5.1E-10
2.6E-12
3.8E-11
3.5E-12
8.1E-12
2.2E-10
External Exposure
(Risk/yr per Bq/g soil)
1.8E-05
6.8E-07
7.6E-08
1.4E-04
5.4E-07
O.OE+00
1.9E-04
O.OE+00
5.4E-05
2.2E-04
O.OE+00
1.5E-04
2.5E-06
5.1E-06
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
" A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq • 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, 0 = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-4
-------
Table 4B: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Copper (29)
Curium (96)
Dysprosium (66)
Erbium (63)
lsotopec
Co-58
Co-58m
Co-60
Cu-64
Cm-242
Cm-243
Cm-244
Cm-245
Cm-246
Cm-247
Cm-248
Dy-165
Dy-166
Er-169
CASRN*
01381-38-9
01381-38-9(m)
010198-40-0
013981-25-4
015510-73-3
015757-87-6
013981-15-2
015621-76-8
015757-90-1
015758-32-4
015758-33-5
013967-64-1
015840-01-4
015840-13-8
Radioactive
Half-life*
7.080E+01
9.150E+00
5.270E+00
1.270E+01
1.630E+02
2.850E+01
1.810E-t-01
8.500E+03
4.750E+03
1.560E+07
3.390E+05
2.330E+00
8.160E+01
9.400E+00
D
H
Y
H
D
Y
Y
Y
Y
Y
Y
H
H
D
ICRP
Lung
Class'
Y
Y
Y
Y
W
W
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)9
3.0E-01
3.0E-01
3.0E-01
5.0E-01
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
3.0E-04
3.0E-04
3.0E-04
Ingestion
(Risk/Bq)
4.3E-11
8.6E-13
4.1E-10
4.6E-12
3.5E-10
5.1E-09
4.3E-09
6.5E-09
6.5E-09
5.9E-09
2.5E-08
4.1E-12
5.1E-11
1.2E-11
Inhalation
(Risk/Bq)
2.6E-10
2.0E-12
4.1E-09
5.4E-12
1.1E-07
7.0E-07
5.9E-07
8.6E-07
8.6E-07
8.1E-07
3.2E-06
3.0E-12
1.4E-10
4.1E-11
External Exposure
(Risk/yr per Bq/g soil)
8.9E-05
1.3E-09
2.3E-04
1.6E-05
9.2E-10
4.3E-06
8.1E-10
1.4E-06
7.3E-10
2.5E-05
5.9E-10
1.5E-06
7.3E-07
2.3E-10
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq). the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a *+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
a Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-5
-------
Table 4B: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Becquerelsb)
JANUARY 19ffi
Element
(Atomic Number)
Europium (63)
Florin (9)
Francium (87)
Gadolinium (64)
Gallium (31)
Germanium (32)
Gold (79)
Isotope0
Er-171
Eu-152
Eu-154
Eu-155
Eu-156
F-18
Fr-221f
Fr-223f
Gd-153
Gd-159
Ga-67
Ga-72
Ge-71
Au-196
CASRN"
01 4391 -45-8
014683*3-9
015585-10-1
014391-16-3
014280-35-4
013981-56-1
015756-41-9
015756-98-6
014276-65-4
014041-42-0
014119-09-6
013982-22-4
014374-81-3
014914-16-0
Radioactive
Half-life*
7.520E+00
1.360E+01
8.800E+00
4.960E+00
1.520E+01
1.100E+02
4.800E+00
2.180E+00
2.420E+02
1.860E+01
3.260E+00
1.410E+01
1.180E+01
6.180E+00
H
Y
Y
Y
D
M
M
M
D
H
D
H
0
D
ICRP
Lung
Class'
W
W
W
W
W
D
D
D
W
W
W
W
W
Y
Gl
Absorption
Factor (f,)g
3.0E-04
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E+00
1.0E+00
1.0E+00
3.0E-04
3.0E-04
1.0E-03
1.0E-03
1.0E+00
1.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
1.2E-11
5.7E-11
8.1E-11
1.2E-11
6.8E-11
2.6E-12
1.6E-12
4.6E-12
8.4E-12
1.6E-11
5.7E-12
3.5E-1 1
1.8E-13
1.1E-11
Inhalation
(Risk/Bq)
1.1E-11
3.0E-09
3.8E-09
4.9E-10
3.0E-10
1.9E-12
2.5E-11
1.1E-11
1.6E-10
1.7E-11
9.7E-12
3.2E-11
3.5E-12
2.4E-11
External Exposure
(Risk/yr per Bq/g soil)
2.5E-05
9.7E-05
1.1E-04
1.6E-06
1.3E-04
8.4E-05
1.7E-06
1.1E-06
2.0E-06
2.4E-06
8.9E-06
2.6E-04
6.2E-10
3.5E-05
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
" A becquerel (Bq). the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure tor that radionuclide only, except when marked with a"+D' to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+0), half-lives are listed for the parent radionudide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide tor instructions. 4B-6
-------
Table 4B: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Becquerelsb)
JANUARY 1992
Element
(Atomic Number)
Holmium (67)
Hydrogen (1)
Indium (49)
Iodine (53)
lsotopec
Au-198
Ho-166
H-3
ln-113m
ln-114
ln-114m
ln-115
ln-115m
1-122
1-123
1-125
1-126
1-129
1-130
CASRN"
010043-49-0
013967-65-2
010028-17-8
014885-78-0(m)
01398-55-0
01398-55-0(m)
014191-71-0
014191-71-0(m)
018287-75-7
015715-08-9
014158-31-7
014158-32-8
015046-84-1
014914-02-4
Radioactive
Half-life6
2.700E+00
2.680E+01
1.230E+01
1.660E+00
7.190E+01
4.950E+01
4.600E+15
4.360E+00
3.620E+00
1.310E+01
6.010E+01
1.290E+01
1.570E+07
1.240E+01
D
H
Y
H
S
D
Y
H
M
H
D
D
Y
H
ICRP
Lung
Class'
Y
W
*
W
W
W
W
W
D
D
D
D
D
D
Gl
Absorption
Factor (f,)9
1.0E-01
3.0E-04
1.0E+00
2.0E-02
2.0E-02
2.0E-02
2.0E-02
2.0E-02
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
3.2E-11
4.6E-1 1
1.5E-12
1.3E-12
1.5E-13
1.5E-10
8.6E-10
3.2E-12
6.8E-13
2.7E-11
2.1E-10
4.1E-10
5.1E-09
2.5E-10
Inhalation
(Risk/Bq)
5.7E-1 1
5.9E-1 1
2.1E-12
7.8E-13
4.1E-14
1.1E-09
5.9E-09
2.5E-12
2.1E-13
1.5E-11
1.4E-10
2.6E-10
3.2E-09
1.4E-10
External Exposure
(Risk/yr per Bq/g soil)
3.2E-05
1.8E-06
O.OE+00
1.9E-05
2.7E-06
4.9E-06
O.OE+00
1.1E-05
8.1E-05
6.5E-06
7.8E-08
3.5E-05
1.1E-07
1.9E-04
Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionudide only, except when marked with a *+D* to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
1 Lung clearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-7
-------
Table 4B: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Becquerelsb)
JWUARY1S92
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Indium (77)
Iron (26)
Krypton (36)
Isotope0
1-131
1-132
1-133
1-134
1-135
lr-190
lr-192
lr-194
Fe-55
Fe-59
Kr-83m
Kr-a5
Kr-flSm
Kr-87
CASRNd
010043-66-0
014683-16-0
014834-67-4
014914-27-3
014834-68-5
014981-91-0
014694-69-0
014158-35-1
014681-59-5
014596-12-4
t 013965-98-5(m)
013983-27-2
013983-27-2(m)
014809-68-8
Radioactive
Half-life8
8.040E+00
2.300E+00
2.080E-I-01
5.260E+01
6.610E+00
1.180E+01
7.400E+01
1.920E+01
2.700E+00
4.460E+01
1.830E+00
1.070E+01
4.480E+00
7.630E+01
D
H
H
M
H
D
D
H
Y
D
H
Y
H
M
ICRP
Lung
Class'
D
D
D
D
D
Y
Y
Y
W
W
*
*
*
*
Gl
Absorption
Factor (f,)fl
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E+00
1.0E-02
1.0E-02
1.0E-02
1.0E-01
1.0E-01
1.0E+00
1.0E+00
1.0E-I-00
1.0E+00
Ingestion
(Risk/Bq)
9.7E-10
2.7E-11
5.7E-10
7.6E-12
1.1E-10
3.8E-11
4.6E-11
4.3E-1 1
7.3E-12
7.6E-1 1
Inhalation
(Risk/Bq)
6.5E-10
1.6E-11
3.2E-10
4.3E-12
6.5E-1 1
1.3E-10
7.3E-10
4.9E-11
2.3E-1 1
2.6E-10
1.7E-15
1.3E-15
1.3E-14
5.9E-14
External Exposure
(Risk/yr per Bq/g soil)
4.1E-05
2.1E-04
5.4E-05
2.4E-04
1.5E-04
1.1E-04
6.5E-05
7.6E-06
O.OE-MX)
1.1E-04
9.2E-10
1.9E-07
9.2E-06
7.6E-05
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-8
-------
Table 4B: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Lanthanum (57)
Lead (82)
Lutetium(71)
Manganese (25)
Isotope1
Kr-88
Kr-89
Kr-90
La-140
Pb-203
Pb-209f
Pb-210'
Pb-210+D
Pb-211f
Pb-212f
Pb-214f
Lu-177
Mn-52
Mn-54
CASRN"
014995-61-0
016316-03-3
015741-13-6
013981-28-7
014687-25-3
014119-30-3
014255-04-0
014255-04-0(+D)
015816-77-0
015092-94-1
015067-28-4
014265-75-9
014092-99-0
013966-31-9
Radioactive
Half-life"
2.840E+00
3.160E+00
3.230E+01
4.020E+01
5.200E+01
3.250E+00
2.230E+01
2.230E+01
3.610E+01
1.060EH-01
2.680E+01
6.710E+00
5.590E+00
3.130E+02
H
M
S
H
H
H
Y
Y
M
H
M
D
D
D
ICRP
Lung
Class'
*
*
•
W
D
D
D
D
D
D
D
Y
W
W
Gl
Absorption
Factor (f,)9
1.0E+00
1.0E+00
1.0E+00
1.0E-03
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
3.0E-04
1.0E-01
1.0E-01
Ingestion
(Risk/Bq)
6.2E-11
8.6E-12
2.3E-12
1.4E-08
1.8E-08
4.9E-12
1.5E-10
4.6E-12
1.7E-11
5.9E-1 1
3.0E-11
Inhalation
(Risk/Bq)
1.3E-13
7.0E-14
6.5E-14
8.1E-11
7.0E-12
1.9E-12
3.5E-08
1.1E-07
7.6E-11
1.2E-09
7.8E-1 1
5.1E-11
1.0E-10
1.4E-10
External Exposure
(Risk/yr per Bq/g soil)
2.0E-04
1.8E-04
1.1E-04
2.2E-04
1.6E-05
O.OE+00
3.5E-09
4.3E-09
4.3E-06
7.6E-06
1.7E-05
1.8E-06
3.2E-04
7.8E-05
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
" A becquerel (Bq), the Sl.unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a "t" are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+0), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, 0 = Day, * = Gas.
g Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-9
-------
Table 4B: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Becquerels")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Mercury (80)
Molybdenum (42)
Neodymium (60)
Neptunium (93)
Nickel (28)
Isotope0
Mn-56
Hg-197
Hg-203
Mo-99
Nd-147
Nd-149
Np-236
Np-237*
Np-237+D
Np-238
Np-239'
Np-240
Np-240m
Ni-59
CASRN"
014681-52-8
013981-51-6
013982-78-0
014119-1S4
014269-74-0
015749-81-2
015700-36-4
013994-20-2
013994-20-2(+D)
015766-25-3
013968-59-7
015690-84-3
015690-84-3(m)
014336-7CW)
Radioactive
Half-life8
2.580E+00
6.410E+01
4.660E+01
6.600E+01
1.100E+01
1.730E+00
1.150E+05
2.140E-I-06
2.140E+06
2.120E+00
2.360E+00
6.500E+01
7.400E+00
7.500E+04
H
H
D
H
D
H
Y
Y
Y
D
D
M
M
Y
ICRP
Lung
Class
W
W
W
Y
Y
Y
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)fl
1.0E-01
2.0E-02
2.0E-02
8.0E-01
3.0E-04
3.0E-04
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-03
5.0E-02
Ingestion
(Risk/Bq)
1.1E-11
7.3E-12
1.8E-11
4.1E-11
3.5E-11
5.1E-12
6.2E-12
5.9E-09
5.9E-09
3.0E-1 1
2.5E-11
3.5E-12
7.8E-13
2.5E-12
Inhalation
(Risk/Bq)
7.6E-12
1.2E-11
1.3E-10
7.0E-11
1.5E-10
4.3E-12
1.1E-10
7.8E-07
7.8E-07
8.9E-11
4.1E-11
1.8E-12
2.4E-13
1.9E-11
External Exposure
(Risk/yr per Bq/g soil)
1.6E-04
1.5E-06
1.5E-05
1.3E-05
8.1E-06
2.6E-05
2.4E-06
2.1E-07
1.2E-05
4.6E-05
6.2E-06
8.6E-05
2.5E-05
O.OE+00
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D* to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D). half-lives are listed for the parent radionudide.
1 Lung clearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year. W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-10
-------
Table 4B: Radionuclide Carcinogenicity - Slope Factors2
(In Units of Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Ni-63
Ni-65
Niobium (41) Nb-93m
Nb-94
Nb-95
Nb-95m
Nb-97
Nb-97m
Osmium (76) Os-185
Os-191
Os-191m
Os-193
Palladium (46) Pd-100
Pd-101
CASRN*1
013981-37-8
014833-49-9
007440-03-1 (m)
014681-63-1
013967-76-5
013967-76-5(m)
018496-04-3
018496-04-3(m)
015766-50-4
014119-24-5
014119-24-5(m)
016057-77-5
015690-69-4
015749-54-9
Radioactive
Half-life6
1.000E+02
2.520E+00
1.460E+01
2.030E+04
3.510E+01
8.660E+01
7.210E+01
6.000E+01
9.360E+01
1.540E+01
1.300E+01
3.000E+01
3.640E+00
8.480E+00
Y
H
Y
Y
D
H
M
S
D
D
H
H
D
H
ICRP
Lung
Class'
W
W
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Gl
Absorption
Factor (f,)fl
5.0E-02
5.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
5.0E-03
5.0E-03
Ingestion
(Risk/Bq)
6.5E-12
7.0E-12
4.1E-12
5.7E-1 1
1.8E-11
1.8E-11
3.2E-12
6.5E-14
1.7E-11
1.8E-11
3.2E-12
2.6E-1 1
2.7E-1 1
3.2E-12
Inhalation
(Risk/Bq)
4.9E-11
5.1E-12
5.1E-10
5.7E-09
1.4E-10
4.3E-11
1.9E-12
3.0E-14
2.4E-10
9.7E-11
5.7E-12
3.2E-11
6.2E-11
3.0E-12
External Exposure
(Risk/yr per Bq/g soil)
O.OE+00
5.1E-05
1.4E-09
1.5E-04
7.0E-05
2.2E-06
5.9E-05
6.8E-05
5.9E-05
2.3E-06
9.2E-08
4.6E-06
Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a *+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
Lung clearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-11
-------
Table 4B: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Becquerelsb)
JANUARY 1992
Element
(Atomic Number) Isotope0
Pd-103
Pd-107
Pd-109
Phosphorus (15) P-32
P-33
Platinum (78) Pt-191
Pt-193
Pt-193m
Pt-197
Pt-197m
Plutonium (94) Pu-236
Pu-238
Pu-239
Pu-240
CASRN"
014967-68-1
017637-99-9
014981-64-7
014596-37-3
015749-66-3
015706-36-2
015735-70-3
015735-70-3(m)
015735-74-7
015735-74-7(m)
015411-92-4
013981-16-3
015117-48-3
014119-33-6
Radioactive
Half-life6
1.700E+01
6.500E+06
1.350E-I-01
1.430E+01
2.540E+01
2.710E+00
5.000E+01
4.330E+00
1.830E+01
9.440E+01
2.850E+00
8.780E+01
2.410E+04
6.570E+03
D
Y
H
D
D
D
Y
D
H
M
Y
Y
Y
Y
ICRP
Lung
Class'
Y
Y
Y
D
D
D
D
D
D
D
Y
Y
Y
Y
Gl
Absorption
Factor (f,)9
5.0E-03
5.0E-03
5.0E-03
8.0E-01
8.0E-01
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-02
1.0E-03
1.0E-03
1.0E-03
1.0E-03
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
5.9E-12
1.2E-12
2.1E-11
9.5E-1 1
1.5E-11
1.0E-11
9.5E-13
1.4E-11
1.3E-11
3.2E-12
1.4E-09
5.9E-09
6.2E-09
6.2E-09
Inhalation
(Risk/Bq)
3.8E-1 1
1.7E-10
2.2E-1 1
8.1E-11
1.2E-11
8.1E-12
2.2E-12
1.1E-11
8.6E-12
2.4E-12
6.5E-07
1.1E-06
1.0E-06
1.0E-06
External Exposure
(Risk/yr per Bq/g soil)
2.0E-08
O.OE+00
5.9E-08
O.OE+00
O.OE+00
1.7E-05
O.OE+00
2.1E-07
8.4E-07
4.3E-06
9.2E-10
7.6E-10
4.6E-10
7.3E-10
8 Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionudide only, except when marked with a VD' to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
' Lung dearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
8 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-12
-------
Table 4B: Radionuclide Carcinogenicity -- Slope Factors8
(In Units of Becquerelsb)
JANUARY 1932
Element
(Atomic Number)
Polonium (84)
Potassium (19)
Praseodymium (59)
Isotope6
Pu-241
Pu-242
Pu-243
Pu-244
Po-210r
Po-212f
Po-213t
Po-214f
Po-215f
Po-216f
Po-218'
K-40
K-42
Pr-142
CASRN"
014119-32-5
013982-10-0
015706-37-3
014119-34-7
013981-52-7
015389-34-1
015756-57-7
015735-67-8
015706-52-2
015756-58-8
015422-24-9
013966-00-2
014378-21-3
014191-64-1
Radioactive
Half-life0
1.440E+01
3.760E+05
4.960E+00
8.260E+07
1.380E+02
2.980E-07
4.200E-06
1.640E-04
1.780E-03
1.460E-01
3.050E+00
1.280E+09
1.240E+01
1.910E+01
Y
Y
H
Y
0
S
S
S
S
S
M
Y
H
H
ICRP
Lung
Class'
Y
Y
Y
Y
W
W
W
W
W
W
W
D
D
Y
Gl
Absorption
Factor (f,)g
1.0E-03
1.0E-03
1.0E-03
1.0E-03
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E-01
1.0E+00
1.0E+00
3.0E-04
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
9.7E-11
5.9E-09
3.0E-12
5.9E-09
4.1E-09
5.9E-22
8.6E-21
2.7E-19
7.6E-18
8.1E-16
7.6E-13
3.0E-10
2.4E-1 1
4.3E-1 1
Inhalation
(Risk/Bq)
6.2E-09
9.7E-07
2.7E-12
9.7E-07
7.0E-08
1.6E-20
2.2E-19
7.6E-18
1.5E-16
1.3E-14
1.6E-11
2.1E-10
3.2E-1 1
4.9E-1 1
External Exposure
(Risk/yr per Bq/g soil)
O.OE+00
6.2E-10
4.9E-07
5.1E-10
7.8E-10
O.OE+00
2.7E-09
7.6E-09
1.2E-08
1.4E-09
O.OE+00
1.5E-05
2.6E-05
5.7E-06
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
" A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionudide only, except when marked with a "+D* to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
0 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
' Lung dearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided (or reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-13
-------
Table 4B: Radionuclide Carcinogenicity - Slope Factors
(In Units of Becquerels")
JANUARY 1982
Element
(Atomic Number)
Promethium (61)
Protactinium (91)
Radium (88)
Isotope0
Pr-143
Pr-144
Pr-144m
Pm-147
Pm-148
Pm-148m
Pm-149
Pa-231'
Pa-233'
Pa-234
Pa-234mT
Ra-223f
Ra-224'
Ra-225*
CASRN"
014981-79-4
014119-05-2
014119-05-2(m)
014380-75-7
014683-19-3
01 4683-1 9-3(m)
015765-31-8
014331-85-2
013981-14-1
015100-28-4
015100-28-4(m)
015623-45-7
013233-32-4
013981-53-8
Radioactive
Half-life"
1.360E+01
1.730E+01
7.200E+00
2.620E+00
5.370E+00
4.130E+01
5.310E+01
3.730E+04
2.700E+01
6.700E+00
1.170E+00
1.140E+01
3.620E+00
1.480E+01
D
M
M
Y
D
D
H
Y
D
H
M
D
D
D
ICRP
Lung
Class'
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
Gl
Absorption
Factor (f,)g
3.0E-04
3.0E-04
3.0E-04
3.0E-04
3.0E-04
3.0E-04
3.0E-04
1.0E-03
1.0E-03
1.0E-03
1.0E-03
2.0E-01
2.0E-01
2.0E-01
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
3.8E-11
2.6E-12
1.0E-12
8.4E-12
8.4E-1 1
6.8E-11
3.2E-11
2.5E-09
2.7E-11
1.8E-11
1.6E-13
1.7E-09
1.0E-09
1.4E-09
Inhalation
(Risk/Bq)
1.9E-10
9.7E-13
4.3E-13
8.1E-10
2.1E-10
1.3E-09
5.1E-11
9.7E-07
2.3E-10
1.5E-11
4.3E-14
8.4E-08
3.2E-08
4.1E-08
External Exposure
(Risk/yr per Bq/g soil)
8.1E-13
3.2E-06
5.7E-08
1.6E-10
5.1E-05
1.8E-04
8.9E-07
7.0E-07
1.1E-05
1.6E-04
9.7E-07
6.2E-06
6.2E-07
5.1E-08
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq). the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a *+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
" Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-14
-------
Table 4B: Radionuclide Carcinogenicity - Slope Factors8
(In Units of Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number)
Radon (66)
Rhodium (45)
Rubidium (37)
Isotope0
Ra-226t
Ra-226+D
Ra-228'
Ra-228+D
Rn-219f
Rn-220f
Rn-222f
Rn-222+D
Rh-103m
Rh-105
Rh-105m
Rh-106
Rb-82
Rb-86
CASRN"
013982-63-3
013982-63-3(+D)
015262-20-1
01 5262-20-1 (+D)
014835-02-0
022481-48-7
014859-67-7
014859-67-7(+D)
007440-1 6-6(m)
014913-89-4
014913-89-4(m)
013967-48-1
014391-63-0
014932-53-7
Radioactive
HalMife*
1.600E+03
1.600E+03
5.750E+00
5.750E+00
3.960E+00
5.560E+01
3.820E+00
3.820E+00
5.610E+01
3.540E+01
4.500E+01
2.990E+01
1.250E+00
1.870E+01
Y
Y
Y
Y
S
S
0
D
M
H
S
S
M
D
ICRP
Lung
Class1
W
W
W
W
*
*
*
•
Y
Y
Y
Y
D
D
Gl
Absorption
Factor (f,)B
2.0E-01
2.0E-01
2.0E-01
2.0E-01
1.0E+00
1.0E+00
1.0E+00
1.0E+00
5.0E-02
5.0E-02
5.0E-02
5.0E-02
1.0E+00
1.0E+00
Ingestion
(Risk/Bq)
3.2E-09
3.2E-09
2.7E-09
2.7E-09
3.8E-11
4.6E-1 1
1.9E-13
1.2E-11
1.7E-14
1.2E-13
3.2E-13
1.6E-10
Inhalation
(Risk/Bq)
8.1E-08
8.1E-08
1.8E-08
1.9E-08
1.2E-12
3.2E-12
2.0E-1 1
2.1E-10
1.1E-13
1.6E-11
9.2E-15
3.2E-14
9.5E-14
1.2E-10
External Exposure
(Risk/yr per Bq/g soil)
3.2E-07
1.6E-04
O.OE+00
7.8E-05
4.3E-06
4.6E-08
3.2E-08
1.6E-04
2.1E-09
5.9E-06
5.9E-07
1.8E-05
9.5E-05
8.9E-06
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D* to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a f are members of a decay chain.
" Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week. D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-1S
-------
Table 4B: Radionuclide Carcinogenicity -- Slope Factors
(In Units of Becquerelsb)
JANUARY 1992
v Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope6
Rb-87
Rb-88
Rb-89
Ruthenium (44) Ru-97
Ru-103
Ru-105
Ru-106
Samarium (62) Sm-147
Sm-151
Sm-153
Scandium (21) Sc-46
Sc-47
Sc-48
Selenium (34) Se-75
CASRN"
013982-13-3
014928-364
014191-65-2
015758-35-7
013968-53-1
014331-95-4
013967-48-1
014392-33-7
015715-94-3
015766XXM
013967-63-0
014391-96-9
014391-86-7
014265-71-5
Radioactive
Half-life"
4.730E+10
1.780E+01
1.540E+01
2.900E+00
3.940E+01
4.440E+00
3.680E+02
1.060E+11
9.000E+01
4.670E+01
8.380E+01
3.420E+00
4.370E+01
1.200E+02
Y
M
M
D
D
H
D
Y
Y
H
D
D
H
D
ICRP
Lung
Class'
D
D
D
Y
Y
Y
Y
W
W
W
Y
Y
Y
W
Gl
Absorption
Factor (f,)9
1.0E+00
1.0E+00
1.0E+00
5.0E-02
5.0E-02
5.0E-02
5.0E-02
3.0E-04
3.0E-04
3.0E-04
1.0E-04
1.0E-04
1.0E-04
8.0E-01
Ingestion
(Risk/Bq)
9.2E-11
4.6E-12
2.5E-12
4.6E-12
2.4E-1 1
1.0E-11
2.6E-10
4.3E-10
3.0E-12
2.4E-1 1
4.3E-1 1
1.7E-11
5.1E-11
1.6E-10
Inhalation
(Risk/Bq)
6.5E-1 1
2.1E-12
1.1E-12
7.0E-12
2.3E-10
8.9E-12
1.2E-08
1.9E-07
2.4E-10
3.5E-1 1
7.3E-10
3.2E-1 1
6.2E-1 1
1.6E-10
External Exposure
(Risk/yr per Bq/g soil)
O.OE+00
6.5E-05
2.0E-04
1.1E-05
4.1E-05
7.0E-05
O.OE+00
O.OE+00
1.1E-11
1.2E-06
1.9E-04
6.2E-06
3.2E-04
2.2E-05
" Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a *f are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
9 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-16
-------
Table 4B: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Becquerels")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Silicon (14) Si-31
Silver (47) Ag-105
Ag-108
Ag-108m
Ag-109m
Ag-110
Ag-110m
Ag-111
Sodium (11) Na-22
Na-24
Strontium (38) Sr-82
Sr-85
Sr-85m
Sr-89
CASRN"
014276-49-4
014928-14-4
014391-65-2
014391-65-2(m)
014378-38-2(m)
014391-76-5
014391 -76-5(m)
0157690-04-0
013966-32-0
013982-04-2
014809-50-8
013967-73-2
013967-73-2(m)
014158-27-1
Radioactive
Half-life0
1.570E-1-02
4.130E+01
2.370E+00
1.270E+02
3.960E+01
2.460E+01
2.500E+02
7.460E+00
2.600E+00
1.500E+01
2.500E-I-01
6.480E+01
6.770E+01
5.060E-H01
M
D
M
Y
S
S
D
D
Y
H
D
D
M
D
ICRP
Lung
Class'
W
Y
Y
Y
Y
Y
Y
Y
D
D
D
D
D
D
Gl
Absorption
Factor (f,)9
1.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
1.0E-I-00
1.0E+00
3.0E-01
3.0E-01
3.0E-01
3.0E-01
Ingestion
(Risk/Bq)
5.9E-12
2.0E-1 1
2.3E-13
9.5E-11
8.9E-15
8.1E-14
1.3E-10
4.3E-1 1
1.8E-10
2.7E-1 1
2.0E-10
2.1E-11
3.2E-13
8.1E-11
Inhalation
(Risk/Bq)
4.6E-12
1.1E-10
6.5E-14
4.1E-09
2.4E-15
2.2E-14
1.9E-09
1.3E-10
1.3E-10
2.6E-1 1
1.9E-10
2.7E-1 1
1.6E-13
7.8E-11
External Exposure
(Risk/yr per Bq/g soiO
8.1E-08
1.4E-06
1.4E-04
3.5E-08
2.7E-06
2.5E-04
2.1E-06
1.9E-04
4.3E-04
3.5E-09
3.8E-05
1.3E-05
1.3E-08
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
" A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq • 27 pCI.
c For each radionudide listed, corresponding slope factors are the risks per unit Intake or exposure for that radionuclide only, except when marked with a % D" to Indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
Or*f4'ir\^r*ti\ta holfJifa* Q — C^w-snrtrl M _ Mirtirttf* H _ Hot* V _ VA**«> CA» U«A/.A *++*£*. MiMi:*Jjt*» i»M* Am+n\t n«w4< i ***«•> / . F\\ hotf IIWAO 4m lietfvJ fnr #Ka no rant ror4i/ini i/-lirta
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent
1 Lung clearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-17
-------
Table 4B: Radionuclide Carcinogenicity -- Slope Factors8
(In Units of Becquerelsb)
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per UnR Intake or Exposure
Element
(Atomic Number)
Sulfur (16)
Tantalum (73)
Technetium (43)
lsotopec
Sr-90'
Sr-90+D
Sr-91
Sr-92
S-35
Ta-182
Tc-95
Tc-95m
Tc-96
Tc-96m
Tc-97
Tc-97m
Tc-99
Tc-99m
CASRN"
010098-97-2
010098-97-2(+D)
014331-91-0
014928-29-1
015117-53-0
013982-00-8
014809-56-4
014809-56-4(m)
014808-44-7
014808-44-7(m)
015759-35-0
015759-35-0(m)
014133-76-7
014133-76-7(m)
Radioactive
Half-life*
2.860E+01
2.860E+01
9.500E+00
2.710E+00
8.740E+01
1.150E-I-02
2.000E+01
6.100E+01
4.280E+00
5.150E+01
2.600E+06
8.900E+01
2.130E+05
6.020E+00
Y
Y
H
H
D
D
H
D
D
M
Y
0
Y
H
ICRP
Lung
Class1
D
D
D
0
D
Y
W
W
W
W
W
W
W
W
Gl
Absorption
Factor (f,)8
3.0E-01
3.0E-01
3.0E-01
3.0E-01
8.0E-01
1.0E-03
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
8.0E-01
Ingestion
(Risk/Bq)
8.9E-10
9.7E-10
2.3E-11
1.5E-11
5.9E-12
4.6E-1 1
1.5E-12
4.9E-11
4.9E-1 1
6.2E-13
4.1E-12
3.0E-1 1
3.5E-11
1.4E-12
Inhalation
(Risk/Bq)
1.5E-09
1.7E-09
1.9E-11
1.2E-11
5.1E-12
1.2E-09
6.2E-13
1.1E-10
5.7E-11
5.7E-13
2.6E-11
1.4E-10
2.2E-10
7.3E-13
External Exposure
(Risk/yr per Bq/g soil)
O.OE+00
O.OE+00
6.5E-05
1.2E-04
O.OE+00
1.1E-04
6.5E-05
5.1E-05
2.2E-04
1.9E-06
9.5E-09
1.0E-08
1.6E-11
6.2E-06
Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
A becquerel (Bq). the SI unit of activity, is equal to one nudear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit Intake or exposure for that radionudide only, except when marked with a VD" to Indicate that the risks
from radioactive decay chain products are also induced. Radionudides designated with a "f are members of a decay chain.
Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and eadi chain member.
" Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e.. multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-18
-------
Table 4B: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Becquerelsb)
JANUARY 1992
Element
(Atomic Number)
Tellurium (52)
Terbium (65)
Thallium (81)
Isotope'
Te-125m
Te-127
Te-127m
Te-129
Te-129m
Te-131
Te-131m
Te-132
Tb-158
Tb-160
Tl-202
71-204
^-207*
TI-208T
CASRN"
014390-73-9(m)
013981-49-2
013981-49-2(m)
014269-71-7
01 4269-71 -7(m)
014683-12-6
01 4683-1 2-6(m)
014234-28-7
015759-55-4
013981-29-8
015720-57-7
013968-51-9
014133-67-6
014913-50-9
Radioactive
Half-life"
5.800E+01
9.350E+00
1.090E+02
6.960E+01
3.360E+01
2.500E+01
3.000E+01
7.820E+01
1.500E+02
7.230E+01
1.220E+01
3.780E+00
4.770E+00
3.050E-t-00
D
H
D
M
D
M
H
H
Y
D
D
Y
M
M
ICRP
Lung
Class'
W
W
W
W
W
W
W
W
W
W
D
D
D
D
Gl
Absorption
Factor (f,)fl
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
2.0E-01
3.0E-04
3.0E-04
1.0E+00
1.0E-I-00
1.0E+00
1.0E+00
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
2.3E-1 1
6.2E-12
5.9E-11
3.0E-12
8.6E-11
7.6E-12
1.0E-10
8.1E-11
3.2E-11
4.9E-11
2.3E-1 1
4.6E-11
3.5E-13
4.9E-13
Inhalation
(Risk/Bq)
1.5E-10
6.2E-12
4.3E-10
1.8E-12
5.4E-10
3.8E-12
1.5E-10
1.4E-10
2.5E-09
5.1E-10
1.6E-11
3.5E-1 1
1.2E-13
1.4E-13
External Exposure
(Risk/yr per Bq/g soil)
7.0E-08
3.8E-07
2.3E-08
3.5E-06
1.7E-06
3.2E-05
1.3E-04
1.1E-05
9.7E-05
3.5E-05
2.4E-08
2.0E-07
3.5E-04
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionudide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a "f are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second. M = Minute, D = Day. Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year. W = Week, D = Day, * = Gas.
0 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-19
-------
Table 4B: Radionuclide Carcinogenicity -- Slope Factors'
(In Units of Becquerels")
JANUARY 1992
Element
(Atomic Number) Isotope0
11-209*
Thorium (90) 171-227*
Th-228f
Th-228+D
171-229*
Th-229+D
Th-230*
Th-231*
Th-232*
171-234*
Thulium (69) Tm-1 70
Tm-171
Tin (50) Sn-113
Sn-121
CASRN*
015690-73-0
015623-47-9
014274-82-9
014274-82-9(+D)
015594-54-4
015594-54-4(+D)
014269-63-7
014932-40-2
2007440-29-1
015065-10-8
013981-30-1
014333-45-0
013966-06-8
014683-06-8
Radioactive
Half-life*
2.200E+00
1.870E+01
1.910E+00
1.910E+00
7.340E+03
7.340E+03
7.700E+04
2.550E+01
1.410E+10
2.410E+01
1.290E+02
1.920E+00
1.150E+02
2.710E+01
M
D
Y
Y
Y
Y
Y
H
Y
D
D
Y
D
H
ICRP
Lung
Class'
D
Y
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
W
Gl
Absorption
Factor (f,)9
1.0E+00
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
2.0E-04
3.0E-04
3.0E-04
2.0E-02
2.0E-02
Slope Factor
Lifeline Excess Total Cancer Risk Per Unit Intake or Exposure
Ingestion
(Risk/Bq)
3.8E-13
1.2E-10
3.0E-10
1.5E-09
5.7E-10
2.4E-09
3.5E-10
1.1E-11
3.2E-10
1.1E-10
4.1E-11
3.2E-12
2.4E-1 1
7.3E-12
Inhalation
(Risk/Bq)
1.2E-13
1.3E-07
2.1E-06
2.1E-06
2.0E-06
2.1E-06
7.8E-07
1.3E-11
7.6E-07
8.6E-10
5.7E-10
8.4E-1 1
2.5E-10
8.6E-12
External Exposure
(Risk/yr per Bq/g soil)
1.9E-04
4.3E-06
1.5E-08
1.5E-04
1.8E-05
1.5E-09
6.2E-08
7.0E-10
9.5E-08
1.0E-07
8.9E-09
8.9E-08
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a VD" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second. M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed tor the parent radionuclide.
' Lung clearance dassification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided (or reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-20
-------
Table 4B: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Becquerels")
JANUARY 19B2
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Sn-121m
Sn-125
Sn-126
Tungsten (74) W-181
W-185
W-187
Uranium (92) U-232
U-233
U-234'
U-235'
U-235+D
U-236
U-237
U-238f
CASRN11
014683-06-8(m)
014683-08-0
015832-50-5
015749-46-9
014932-41-3
014983-48-3
014158-29-3
013968-55-3
013966-29-5
015117-96-1
01 511 7-96-1 (+D)
013982-70-2
014269-75-1
007440-61-1
Radioactive
Half-life*
5.550E+01
9.640E+00
1.000E+05
1.210E+02
7.510E+01
2.380E+01
7.200E+01
1.590E+05
2.450E+05
7.040E+08
7.040E-I-08
2.340E+07
6.750E+00
4.470E+09
Y
0
Y
D
0
H
Y
Y
Y
Y
Y
Y
0
Y
ICRP
Lung
Class'
W
W
W
D
D
D
Y
Y
Y
Y
Y
Y
Y
Y
Gl
Absorption
Factor (f,)8
2.0E-02
2.0E-02
2.0E-02
3.0E-01
3.0E-01
3.0E-01
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
5.0E-02
Ingestion
(Risk/Bq)
1.5E-11
9.7E-11
1.5E-10
2.2E-12
1.3E-11
1.7E-11
1.0E-09
4.3E-10
4.3E-10
4.3E-10
4.3E-10
4.1E-10
2.4E-1 1
4.3E-10
Inhalation
(Risk/Bq)
2.5E-10
3.2E-10
2.1E-09
1.7E-12
8.1E-12
1.1E-11
1.6E-06
7.3E-07
7.0E-07
6.8E-07
6.8E-07
6.8E-07
7.0E-1 1
6.5E-07
External Exposure
(Risk/yr per Bq/g soil)
3.0E-05
8.9E-07
5.9E-07
1.3E-09
4.1E-05
1.2E-09
1.1E-09
8.1E-10
6.5E-06
6.5E-06
6.5E-10
3.5E-06
5.7E-10
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq • 27 pCi.
c For each radionudide listed, corresponding slope factors are trie risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionuclides with decay products (+D), half-lives are listed for (tie parent radionuclide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung classifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-21
-------
Table 4B: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Becquerelsb)
JANUARY 19G2
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
U-238+D
U-240
Vanadium (23) V-48
Xenon (54) Xe-122
Xe-123
Xe-125
Xe-127
Xe-129m
Xe-131m
Xe-133
Xe-133m
Xe-135
Xe-135m
Xe-137
CASRN*
007440-61-1 (+D)
015687-53-3
014331-97-6
015151-09-4
01 5700-1 0-4
013994-18-8
013994-19-9
013965-99-6(m)
014683-1 1-5(m)
014932-42-4
014932-42-4(m)
014995-62-1
014995-62-1(m)
014835-21-3
ICRP
Radioactive Lung
Half-life" . Class'
4.470E+09
1.410E+01
1.600E+01
2.010E+01
2.140E+00
1.680E+01
3.640E+01
8.890E-fOO
1.180E+01
5.250E+00
2.190E+00
9.110E+00
1.540E-f01
3.830E+00
Y Y
H Y
D W
H
H
H
D
D
D
D
D
H
M
M
Gl
Absorption Ingestion
Factor (f,)9 (Risk/Bq)
5.0E-02 7.6E-10
5.0E-02 3.2E-1 1
1.0E-02 5.9E-11
1 OF 1 00
1 OEiOO
1 OFiOO
1 nFion
1 flF.ifin
1 QFiOO
1 OFiflft
i fiFinn
1 fiFiHO
1 HFifln
1 OF 4 00
Inhalation
(Risk/Bq)
1.4E-06
3.2E-1 1
2.1E-10
8.9E-14
2.0E-14
1.1E-14
1.1E-14
1.6E-14
1.2E-14
1.2E-14
1.5E-14
2.2E-14
5.7E-15
4.9E-14
External Exposure
(Risk/yr per Bq/g soil)
9.7E-07
4.1E-09
2.7E-04
2.3E-06
4.6E-05
1.3E-05
1.4E-05
3.5E-07
1.2E-07
6.2E-07
8.9E-07
1.7E-05
3.5E-05
1.6E-05
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq « 27 pCI.
c For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionudide only, except when marked with a VD" to indicate that the risks
from radioactive decay chain products are also included. Radionudides designated with a T are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionudide and each chain member.
6 Radioactive half-life: S = Second, M = Minute, D = Day, Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
1 Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided for reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-22
-------
Table 4B: Radionuclide Carcinogenicity - Slope Factors'
(In Units of Becquerels")
JANUARY 1992
Slope Factor
Lifetime Excess Total Cancer Risk Per Unit Intake or Exposure
Element
(Atomic Number) Isotope0
Xe-138
Yttrium (39) Y-90T
Y-91
Y-91m
Y-92
Y-93
Zinc (30) 2n-65
Zn-69
Zn-69m
Zirconium (40) Zr-93
Zr-95
Zr-97
CASRN"
015751-81-2
010098-91-6
014234-24-3
014234-24-3(m)
015751-59-4
014981-70-5
013982-39-3
013982-23-5
013982-23-5(m)
015751-77-6
013967-71-0
014928-30-4
Radioactive
Half-life"
1.410E+01
6.410E+01
5.850E+01
4.970E+01
3.540E+00
1.010E+01
2.440E+02
5.560E+01
1.380E+01
1.530E+06
6.400E+01
1.690E-I-01
M
H
D
M
H
H
D
M
H
Y
D
H
ICRP
Lung
Class'
•
Y
Y
Y
Y
Y
Y
Y
Y
W
W
W
Gl
Absorption
Factor (f,)fl
1.0E+00
1.0E-04
1.0E-04
1.0E-04
1.0E-04
1.0E-04
5.0E-01
5.0E-01
5.0E-01
2.0E-03
2.0E-03
2.0E-03
Ingestion
(Risk/Bq)
8.6E-1 1
7.6E-11
5.9E-13
1.9E-11
3.8E-1 1
2.3E-10
1.5E-12
1.2E-11
4.6E-12
2.7E-1 1
6.5E-1 1
Inhalation
(Risk/Bq)
7.6E-14
1.5E-10
1.3E-09
9.5E-13
1.6E-11
3.8E-11
4.3E-10
8.6E-13
1.5E-11
1.8E-10
2.7E-10
6.8E-11
External Exposure
(Risk/yr per Bq/g soil)
1.1E-04
O.OE+00
3.2E-07
4.6E-05
2.3E-05
8.1E-06
5.4E-05
4.9E-10
3.5E-05
O.OE+00
6.8E-05
1.6E-05
a Calculated by the EPA Office of Radiation Programs (ORP). EPA classifies all radionudides as Group A carcinogens. For guidance, refer to the User's Guide for radionudides.
b A becquerel (Bq), the SI unit of activity, is equal to one nuclear transformation per second. 1 Bq - 27 pCi.
0 For each radionudide listed, corresponding slope factors are the risks per unit intake or exposure for that radionuclide only, except when marked with a "+D" to indicate that the risks
from radioactive decay chain products are also inducted. Radionudides designated with a 'f are members of a decay chain.
d Chemical Abstract Service Reference Number. For risk calculations involving decay chains, a CASRN should be reported for the parent radionuclide and each chain member.
8 Radioactive half-life: S = Second, M = Minute, D = Day. Y = Year. For those radionudides with decay products (+D), half-lives are listed for the parent radionudide.
' Lung clearance classification recommended by the International Commission on Radiological Protection (ICRP): Y = Year, W = Week, D = Day, * = Gas.
9 Gl absorption factors are the fractional amount of the radionudide absorbed across the Gl tract into the bloodstream. Lung dassifications and Gl absorption values
are provided (or reference only. Do not use these factors to adjust (i.e., multiply or divide) inhalation or ingestion slope factors. See the User's Guide for instructions. 4B-23
-------
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(OTHER THAN CARCINOGENICITY) January 1992
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R1-1
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ACETOPHENONE 000098-86-2
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
WASHINGTON, DC.
005269 GARABRANT DH, L BERNSTEIN, JM PETERS ET AL. 1985. RESPIRATORY EFFECTS OF BORAX DUST. BR J IND MED. 42: 831-837.
US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BORON AND BORON COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
BORON TRIFLUORIDE 007637-07-2
010395 RUSCH GM, GM HOFFMAN, RF MCCONNELL ET AL. 1986. INHALATION TOXICITY STUDIES WITH BORON TRIFLUORIDE. TOXICOL APPL
PHARMACOL. 83: 69-78.
US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BORON AND BORON COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
AND EMERGENCY RESPONSE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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BROMINATED DIBENZO-P-DIOXINS
005859 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZO-P-DIOXINS. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON. DC.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZOFURANS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON. DC.
BROMINATED DIBENZOFURANS
005859 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZOFURANS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIBENZO-P-DIOXINS. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON. DC.
BROMOACETONE . 000598-31-2
005860 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOACETONE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
BROMOCHLOROETHANES
005861 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOCHLOROETHANES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
BROMODICHLOROMETHANE 000075-27-4
005718 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF BROMODICHLOROMETHANE IN F344/N RATS AND
B6C3F1 MICE (GAVAGE STUDIES). NTP TECH REPORT, SER NO 321, NIH PUBL NO 87-2537.
005715 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
WASHINGTON, DC.
BROMODIPHENYL ETHER, P- 000101-55-3
005864 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 4- BROMOPHENYL PHENYL ETHER. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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BROMOFORM 000075-25-2
005722 NTP (NATIONAL TOXICOLOGY PROGRAM). 1989. TOXICOLOGY AND CARCINOGENICITY STUDIES OF TRIBROMOMETHANE AND BROMOFORM IN F344 RATS
AND B6C3F1 MICE (GAVAGE STUDIES). NTP-350.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BROMOFORM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
US EPA. 1987. HEALTH AND ENVIRONMENTAL ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND
REMEDIAL RESPONSE, WASHINGTON, DC.
BROMOMETHANE 000074-83-9
005862 DANSE LH, FL VAN VELSEN AND CA VAN DER HEIJDEN. 1984. METHYL BROMIDE: CARCINOGENIC EFFECTS IN THE RAT FORESTOMACH. TOXICOL
APPL PHARMACOL. 72: 262-271.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR BROMOMETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL BROMIDE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
005863 RUSSO JM, WK ANGER, JV SETZER AND WS BR1GHTWELL. 1984. NEUROBEHAVIORAL ASSESSMENT OF CHRONIC LOW-LEVEL METHYL BROMIDE
EXPOSURE IN THE RABBIT. J TOXICOL ENVIRON HEALTH. 14: 247-255.
905863 REUZEL, PGJ, CF KUPER, HC DREEF-VAN DER MEULEN AND VMM HOLLANDERS. 1987. CHRONIC (29-MONTH) INHALATION TOXICITY AND CARCINOGENICITY
STUDY OF METHYL BROMIDE IN RATS. REPORT NO. V86.469/221044. NETHERLANDS ORGANIZATION FOR APPLIED SCIENTIFIC RESEARCH, DIVISION FOR
NUTRITION AND FOOD RESERACH, TNO. EPA/OTS DOCUMENT #86-8700001202.
REUZEL, PGH, HC DREEF-VAN DER MEULEN, VMM HOLLANDERS, CF KUPER, VJ FERON, CA VAN DER HEIJDEN. 1991. CHRONIC INHALTION TOXICITY AND
CARCINOGENICITY STUDY OF METHYL BROMIDE IN WISTAR RATS. FOOD CHEM. TOXICOL. (29(1): 31-39.
BROMOPHOS 002104-96-3
005865 LEUSCHNER F, A LEUSCHNER AND E POPPE. 1967. CHRONISCHER REPRODUKTIONSVERSUCH UBER 3 GENERATIONEN AN WISTAR-RATTEN 8EI
FORTDAUERNER VERABREICHUNG VON BROMOPHOS. REPORT CH BOEHRINGER SOHN. (UNPUBLISHED).
o
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOPHOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
BROMOXYNIL 001689-84-5
005866 UNION CARBIDE AGRICULTURE PRODUCTS, INC. 1982. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO. 00096521.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOXYNIL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
BROMOXYNIL OCTANOATE 001689-99-2
005867 UNION CARBIDE AGRICULTURE PRODUCTS, INC. 1982. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO. 00096521.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOXYNIL OCTANOATE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
BUSAN 77 031512-74-0
005868 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUSAN 77. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
BUSAN 90 002491-38-5
005869 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUSAN 90. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
BUTANOL, 1- 000071-36-3
005870 US EPA. 1986. BUTANOL: RAT ORAL SUBCHRONIC TOXICITY STUDY. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1- BUTANOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
BUTYL BENZYL PHTHALATE, N- 000085-68-7
005616 NTP (NATIONAL TOXICOLOGY PROGRAM). 1985. PROJECT NO 12307-02, - 03. HAZELTON LABORATORIES AMERICA, INC, UNPUBLISHED STUDY.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
WASHINGTON, DC.
US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR PHTHALIC ACID ESTERS (PAE)S. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER,
WASHINGTON, DC.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR BUTYL BENZYL PHTHALATE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
BUTYLATE 002008-41-5
005871 STAUFFER CHEMICAL COMPANY. 1987. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO. 40289101.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUTYLATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
BUTYLCHLORIDE,t- 000507-20-0
005810 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND
. ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
BUTYROLACTONE, GAMMA- 000096-48-0
005872 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BUTYROLACTONE, GAMMA. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CACODYLIC ACID 000075-60-5
005873 NEES PO. 1968. REPORT ON CACODYLIC ACID TOXICITY TO ANIMALS. WISCONSIN ALUMNI RES FOUND. EPA PESTICIDE PETITION NO OF0911.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CACODYLIC ACID. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CADMIUM 007440-43-9
005280 US EPA. 1985. DRINKING WATER CRITERIA DOCUMENT ON CADMIUM. OFFICE OF DRINKING WATER, WASHINGTON, DC. FINAL DRAFT.
US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CADMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS,
WASHINGTON, DC. EPA-440/5-80-025.
CALCIUM CYANIDE 000592-01-8
010258 HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.
PHILBRICK DJ, JB HOPKINS, DC HILL, JC ALEXANDER AND RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING
IN RATS. J TOXICOL ENVIRON HEALTH. 5: 579-592.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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CAPROLACTAM 000105-60-2
005282 POWERS, WJJ, JC PECKHAM, KM SI I NO AND SC GAD. 1984. EFFECTS OF SUBCHRONIC DIETARY CAPROLACTUM ON RENAL FUNCTION. PROC SYMP
IND APPROACH CHEM RISK ASSESSMENT. CAPROLACTAM RELAT COMPD CASE STUDY 77-96 IND HEALTH FOUND, PITTSBURGH, PA.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CAPROLACTAM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
005284 SEROTA, DG, AM HOBERMAN AND SC GAD. 1984. A THREE GENERATION REPRODUCTION STUDY WITH CAPROLACTAM IN RATS. PROC SYMP IND
APPROACH CHEM RISK ASSESSMENT: CAPROLACTAM RELAT COMPD CASE STUDY 191-204 IND, HEALTH FOUND PITTSBURGH, PA.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CAPROLACTAM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
CAPTAFOL 002425-06-1
005874 ORTHO-CHEVRON CHEMICAL COMPANY. 1985. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 260671, MRID NO.
00149488, 00155196.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAFOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
CAPTAN 000133-06-2
005875 CHEVRON CHEMICAL COMPANY. 1982. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO. 00125293.
STAUFFER CHEMICAL COMPANY. 1982 CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO. 00120315
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CAPTAN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
CARBARYL 000063-25-2
005876 CARPENTER CP, CW WEIL, PE POLIN, ET AL. 1961. MAMMALIAN TOXICITY OF 1-NAPHTHYL-N-METHYLCARBAMATE (SEVIN INSECTICIDE). J AGRIC
FOOD CHEM. 9: 30-39.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBARYL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE. WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
CARBOFURAN 001563-66-2
005877 FMC CORPORATION. 1983. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 250740-250755. MRID NO. 00129507.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBOFURAN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
CARBON DISULFIDE 000075-15-0
010259 HARDIN BD, GP BOND, MR SIKOR, FD ANDREW, RP BELILES AND RW NIEMEIR. 1981. TESTING OF SELECTED WORKPLACE CHEMICALS FOR
TERATOGENIC POTENTIAL. SCAND J WORK ENVIRON HEALTH. 7CSUPPL 4): 66-75.
010430 TABACOVA S, LA HINKOVA, L BALABAEVA. 1978. CARBON DISULFIDE TERATOGENICITY AND POSTNATAL EFFECTS IN RATS. TOXICOL LETT
2(3):129-133.
TABACOVA S, B NIKIFOROV, L BALABAEVA. 1983. CARBON DISULFIDE INTRAUTERINE SENSITIZATION. J APPL TOXICOL 3(5): 233-239.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CARBON DISULFIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
CARBON MONOXIDE 000630-08-0
910430 REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
CARBON TETRACHLORIDE 000056-23-5
005288 BRUCKNER, JV, WF MACKENZIE, S MURALIDHARA, ET AL. 1986. ORAL TOXICITY OF CARBON TETRACHLORIDE: ACUTE, SUBACUTE AND
SUBCHRONIC STUDIES IN RATS. FUND APPL TOXICOL 6<1):16-34.
CHLORAL 000075-87-6
005290 SANDERS, VM, BM KAUFFMANN, KL WHITE, JR. 1982. TOXICOLOGY OF CHLORAL HYDRATE IN THE MOUSE. ENVIRON HEALTH PERSPECT
44:146-173.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORAL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
CHLORDANE 000057-74-9
005296 VELSICOL CHEMICAL CORP. 1983. ACC NO 252267, MRID NO. 00138591, 00144313. AVAILABLE FROM EPA UNDER FOI.
CHLORINE CYANIDE 000506-77-4
010261 HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.
PHILBRICK DJ, JB HOPKINS, DC HILL, JC ALEXANDER AND RG THOMSON. 1979. EFFECTS OF PROLONGED CYANIDE AND THIOCYANATE FEEDING
IN RATS. J TOXICOL ENVIRON HEALTH. 5: 579-592.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
CHLORO-M-CRESOL, P- 000059-50-7
005366 MADSEN, C, PH ANDERSEN, 0 MEYER AND G UURTZEN. 1986. 4-CHLORO-E-METHYLPHENOL: SALMONELLA/MAMMALIAN-MICROSOME MUTAGENICITY
TEST AND SUBACUTE TOXICITY TEST IN RATS. BULL ENVIRON CONTAM TOXICOL 37(5):651-654.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR P-CHLORO-M-CRESOL. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CHLORO-1.3-BUTADIENE, 2- 000126-99-8
REFER TO REFERENCES FOR HEAST TABLE 2.
CHLOROACETALDEHYDE 000107-20-0
005342 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROACETALDEHYDE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CHLOROACETIC ACID 000079-11-8
005346 IRDC (INTERNATIONAL RESEARCH AND DEVELOPMENT CORPORATION). 1982. SUBCHRONIC ORAL TOXICITY TEST WITH MONOCHLOROACETIC ACID IN
RATS. NATIONAL TOXICOLOGY PROGRAM, BETHESDA, MD P 1-101.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROACETIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
' ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
CHLOROANILINE, 2- 000095-51-2
005347 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROANILINES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CHLOROANILINE, 3- 000108-42-9
005348 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROANILINES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CHLOROANILINE, 4- 000106-47-8
005349 NCI (NATIONAL CANCER INSTITUTE). 1979. BIOASSAY OF P-CHLOROANILINE FOR POSSIBLE CARCINOGENICITY. NCI CARC. TECH. REP. SER.
NO. 189. NTIS PB-295896.
US EPA. 1987. HEALTH AND ENVIRONMETNAL EFFECTS DOCUMENT FOR CHLOROANILINES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
CHLOROBENZENE 000108-90-7
005354 MONSANTO COMPANY. 1967. 13-WEEK ORAL ADMINISTRATION—DOGS. MONOCHLOROBENZENES. FINAL REPORT. PROJECT NO. 241-105.
FEBRUARY 24. PREPARED BY HAZELTON LABORATORIES.
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US EPA. 1985. HEALTH ASSESSMENT DOCUMENT FOR CHLORINATED BENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
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ASSESSMENT,ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
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CHLOROBENZILATE 000510-15-6
010260 CIBA-GEIGY CORPORATION. 1984. MRID NO 00144691.
CHLOROBENZOIC ACID, P- 000074-11-3
005360 KIECKEBUSCH, W, W GRIEM AND K LANG. 1960. THE TOLERABILITY OF P- CHLOROBENZOIC ACID. ARZNEIMI HEL-FORSCH 10:999-10001.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR P-CHLOROBENZOIC ACID. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CHLOROBENZOTRIFLUORIDE, 4- 000098-56-6
005364 HOOKER CHEMICAL CORP. 1981. MODIFIED 90-DAY GAVAGE AND REPRODUCTION STUDY IN RATS PCBTF. CONDUCTED BY ELARS BIORESEARCH
LABORATORIES, INC, FORT COLLINS, CO, US EPA/OPTS PUBLIC FILES. MICROFICHE #OTS0508148.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4- CHLOR08ENZOTRIFLUORIDE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CHLOROBUTANE, 1- 000109-69-3
005806 NTP (NATIONAL TOXICOLOGY PROGRAM), 1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF N-BUTYL CHLORIDE IN F344/N RATS AND
005808 B6C3F1 MICE (GAVAGE STUDIES). CAS NO 109-69-3. NTP-TR-312, 198 P.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CHLOROBUTANE, 2- 000078-86-4
005809 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR MONOCHLOROBUTANES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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CHLOROCYCLOPENTADIENE 041851-50-7
005297 US EPA. 1987. HEALTH AND ENVIRONMETNAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CHLOROFORM 000067-66-3
005372 HEYWOOD, R, RJ SORTUELL, PRB NOEL ET AL. 1979. SAFETY EVALUATION OF TOOTHPASTE CONTAINING CHLOROFORM. III. LONG-TERM STUDY IN
BEAGLE DOGS. J. ENVIRON. PATHOL. TOXICOL. 2: 835-851.
CHLOROMETHANE 000074-87-3
010005 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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CHLORONITROBENZENE, M- 000121-73-3
005879 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORONITROBENZENES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CHLOROPHENOL, 2- 000095-57-8
010436 EXON, JH, LD KOELLER. 1982. EFFECTS OF TRANSPLACENTAL EXPOSURE TO CHLORINATED PHENOLS. ENVIRON HEALTH PERSPECT 46:137-140.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR 2-CHLOROPHENOL AND 2,4- DICHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND
REMEDIAL RESPONSE, WASHINGTON, DC.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2- CHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
CHLOROPHENOL, 3- 000108-43-0
005309 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CHLOROPHENOL, 4- 000106-48-9
005310 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE. WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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CHLOROPROPANE, 2- 000075-29-6
010444 GAGE, JC. 1970. THE SUBACUTE INHALATION TOXICITY OF 109 INDUSTRIAL CHEMICALS. BRJ INO MED 27(1):1-18.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2-CHLOROPROPANE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CHLOROTOLUENE, M- 000108-41-8
005880 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROTOLUENES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CHLOROTOLUENE, 0- 000095-49-8
010167 GIBSON, WR, FO GOSSETT, GR KOEN1G, F MARROQUIN. 1974. THE TOXICITY OF DAILY ORAL DOSES OF 0-CHLOROTOLUENE IN THE RAT.
TOXICOLOGY DIVISION, LILLY RESEARCH LABORATORIES. SUBMITTED TO TEST RULES DEVELOPMENT BRANCH, OFFICE OF TOXIC SUBSTANCES,
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CHLOROTOLUENE, P- 000106-43-4
010200 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROTOLUENES. PREPARED BY THE OFFICE OF HEALTH AND
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EMERGENCY RESPONSE, WASHINGTON, DC.
CHLORPYRIFOS 002921-88-2
005881 DOW CHEMICAL COMPANY. 1972. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 112118.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORPYRIFOS AND CHLOROPYRIFOS-METHYL. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID
WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
CHLORPYRIFOS METHYL 005598-13-0
005882 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORPYRIFOS AND CHLORPYRIFOS-METHYL. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID
WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
CHLORTHALONIL 001897-45-6
005883 DIAMOND SHAMROCK CHEMICAL COMPANY. 1970. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 111253, MRID NO.
00057702, 00114034.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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CHLORTHIOPHOS 060238-56-4
005884 WORTHING CR AND SB WALKER, ED. 1983. THE PESTICIDE MANUAL, 7TH ED. BRITISH CROP PROTECTION COUNCIL, THE LAVENHAM PRESS LTD.
SUFFOLK, ENGLAND. P 130.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLORTHIOPHOS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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CHROMIUM (III) 016065-83-1
005731 IVANKOVIC, S AND R PREUSSMAN. 1975. ABSENCE OF TOXIC AND CARCINOGENIC EFFECTS AFTER ADMINISTRATIONS OF HIGH DOSES OF CHROMIC
OXIDE PIGMENT IN SUBACUTE AND LONG-TERM FEEDING EXPERIMENTS IN RATS. FOOD COSMET TOXICOL 13: 347-351.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR TRIVALENT CHROMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
WASHINGTON, DC.
CHROMIUM (VI) 018540-29-9
005522 MACKENZIE, RD, RU BYERRUM, CF DECKER ET AL. 1958. CHRONIC TOXICITY STUDIES, II. HEXAVALENT AND TRIVALENT CHROMIUM
ADMINISTERED IN DRINKING WATER TO RATS. AM MED ASSOC ARCH IND HEALTH 18: 232-234.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR HEXAVALENT CHROMIUM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
WASHINGTON, DC.
CHRYSENE 000218-01-9
005885 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHRYSENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
COPPER 007440-50-8
005374 US EPA. 1987. DRINKING WATER CRITERIA DOCUMENT FOR COPPER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER, WASHINGTON, DC.
COPPER CYANIDE 000544-92-3
010262 US EPA. 1986. 90 DAY ORAL TOXICITY STUDY OF COPPER CYANIDE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
CRESOL, M- 000108-39-4
005380 US EPA. 1986. 0,M,P-CRESOL. 90-DAY ORAL SUBCHRONIC TOXICITY STUDIES IN RATS. OFFICE OF SOLID WASTE, WASHINGTON, DC.
US EPA. 1987. 0,M,P-CRESOL. 90-DAY ORAL SUBCHRONIC NEUROTOXICITY STUDY IN RATS. OFFICE OF SOLID WASTE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
CRESOL, 0- 000095-48-7
005384 US EPA. 1986. 0,«,P-CRESOL. 90-DAY ORAL SUBCHRONIC TOXICITY STUDIES IN RATS. OFFICE OF SOLID WASTE, WASHINGTON, DC.
US EPA. 1987. 0,M,P-CRESOL. 90-DAY ORAL SUBCHRONIC NEUROTOXICITY STUDY IN RATS. OFFICE OF SOLID WASTE, WASHINGTON, DC.
CRESOL, P- 000106-44-5
005388 US EPA. 1986. 0,M,P-CRESOL. 90-DAY ORAL SUBCHRONIC TOXICITY STUDIES IN RATS. OFFICE OF SOLID WASTE, WASHINGTON, DC.
US EPA. 1987. 0,M,P-CRESOL. 90-DAY ORAL SUBCHRONIC NEUROTOXICITY STUDY IN RATS. OFFICE OF SOLID WASTE, WASHINGTON, DC.
CUMENE 000098-82-8
005392 WOLF, MA, VK ROWE, 00 MCCOLLISTER, RL HOLLINGSWORTH AND F OYEN. 1956. TOXICOLOGICAL STUDIES OF CERTAIN ALKYLATED BENZENE AND
BENZENES. AHA ARCH IND HEALTH 14:387-398.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CUMENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
005908 MONSANTO COMPANY. 1986. ONE MONTH STUDY OF CUMENE VAPOR ADMINISTERED TO MALE AND FEMALE SPRAGUE-DAWLEY RATS BY INHALATION. US
EPA/OTS PUBLIC FILES, 80 SUBMISSION. MICROFICHE # OTS 0513229.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CUMENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
CYANAZINE 021725-46-2
010411 E.I. DU PONT DE NEMOURS AND COMPANY, INC. 1986. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO. 40081901
AND 40229001.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYANAZINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
CYANIDE (CN-) 000057-12-5
005396 HOWARD, JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. J AGRIC FOOD CHEM 3:325-329.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR CYANIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
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CYANOGEN 000460-19-5
010263 HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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CYANOGEN BROMIDE 000506-68-3
010264 HOWARD JU AND RF HANZAL; 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.
CYCLOATE 001134-23-2
005886 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYCLOATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
CYCLOHEXANOL 000108-93-0
005887 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYCLOHEXANOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
CYCLOHEXYLAMINE 000108-91-8
005398 GAUNT, IF, M SHARRATT, PG GRASSO, AB LANSDOWN AND SD GANGOLLI. 1974. SHORT-TERM TOXICITY OF CYCLOHEXYLAMINE HCL IN THE RAT.
FOOD COSMET TOXICOL 12:609-624.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOHEXYLAMINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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005400 GAUNT, IF, J HARDY, P GRASSO, SD GANGOLLI AND KR BUTTERWORTH. 1976. LONG-TERM TOXICITY OF CYCLOHEXYLAMINE HYDROCHLORIDE IN
THE RAT. FOOD COSMET TOXICOL 14(4):255-268.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOHEXYLAMINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
CYCLOPENTADIENE 000542-92-7
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DACTHAL 001861-32-1
005888 DIAMOND SHAMROCK AGRICULTURAL CHEMICALS. 1963. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO. 00083584.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DACTHAL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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DALAPON 000075-99-0
005889 PAYNTER OE, TU TUSING, DD MCCOLLISTER AND VK ROUE. 1960. TOXICOLOGY OF DALAPON SODIUM (2,2-DICHLOROPROPIONIC ACID, SODIUM
SALT). J AGRIC FOOD CHEM. 8: 47-51.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DALAPON. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
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DDT 000050-29-3
005408 LAUG, EP, AA NELSON, OG FITZHUGH AND FM KUNZE. 1950. LIVER CELL ALTERATION AND DDT STORAGE IN THE FAT OF THE RAT INDUCED BY
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DECABROMODIPHENYL ETHER 001163-19-5
005891 KOCIBA RJ, LO FRAUSON CG HUMISTON, ET AL. 1975. RESULTS OF A TWO- YEAR DIETARY FEEDING STUDY WITH DECABROMODIPHENYL OXIDE
(DCDPO) IN RATS. COMBUST TOXICOL. 2(4): 267-285.
NORRIS JM, JW EHRMANTRAUT, CL GIBBONS, ET AL. 1975. TOXICOLOGY OF OCTABROMOBIPHENYL AND DECABROMODIPHENYL OXIDE. ENVIRON
HEALTH PERSPECT. 11: 153-161.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMINATED DIPHENYL ETHER. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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DIAZINON 000333-41-5
005892 DAVIES DB AND BJ HOLUB. 1979. COMPARATIVE SUSCEPTIBILITY OF MALE AND FEMALE RATS TO DIETARY DIAZINON TOXICITY. J NUTR.
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DAVIES DB AND BJ HOLUB. 1980. COMPARATIVE SUBACUTE TOXICITY OF DIETARY DIAZINON IN THE MALE AND FEMALE RAT. TOXICOL APPL
PHARMACOL. 54(3): 359-367.
DAVIES DB AND BJ HOLUB. 1980. TOXICOLOGICAL EVALUATION OF DIETARY DIAZINON IN THE RAT. ARCH ENVIRON CONTAM TOXICOL. 9(6):
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US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIAZINON. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON, DC.
DIBENZOFURAN 000132-64-9
005409 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR DIBENZOFURAN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
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DIBROMOBENZENE, 1,4- 000106-37-6
005893 CARLSON GP AND RG TARDIFF. 1977. EFFECT OF 1,4-DIBROMOBENZENE AND 1,2,4-TRIBROMOBENZENE ON XENOBIOTIC METABOLISM. TOXICOL
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US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
DIBROMOCHLOROMETHANE 000124-48-1
005894 NTP (NATIONAL TOXICOLOGY PROGRAM). 1985. TOXICOLOGY AND CARCINOGENESIS STUDIES OF CHLORODIBROMOMETHANE IN F344/N RATS AND
B6C3F1 MICE (GAVAGE STUDIES). NTP TR282. NTIS PB86-166675.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR BROMOCHLOROMETHANES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DIBROMOCHLOROMETHANE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DIBUTYL PHTHALATE 000084-74-2
005622 SMITH, CC. 1953. TOXICITY OF BUTYL STEARATE, DIBUTYL SEBACATE, DIBUTYL PHTHALATE AND METHOXYETHYL OLEATE. ARCH HYG OCCUP MED
7: 310-318.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR SELECTED PHTHALIC ACID ESTERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
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DICHLOROBENZENE, 1,2- 000095-50-1
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DICHLOROBENZENE, 1,3- 000541-73-1
005414 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR DICHLOROBENZENES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
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DICHLOROBENZENE, 1,4- 000106-46-7
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005415 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DICHLOROBUTENES. PREPARED BY THE OFFICE OF HEALTH AND
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DICHLORODIFLUOROMETHANE 000075-71-8
005496 CLAYTON, WJ, JR. 1967. FLUOROCARBON TOXICITY AND BIOLOGICAL ACTION. FLUORINE CHEM REV 1(2): 197-252.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR FULLY HALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
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DICHLOROETHANE, 1,1- 000075-34-3
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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DICHLOROETHYLENE, 1,2-C- 000156-59-2
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DICHLOROETHYLENE, 1,2-T- 000156-60-5
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DICHLOROPHENOL, 2,3- 000576-24-9
005315 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
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DICHLOROPHENOL, 2,4- 000120-83-2
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DICHLOROPHENOL, 2,5- 000583-78-8
005316 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DICHLOROPHENOL, 2,6- 000087-65-0
005317 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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R1-27
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
DICHLOROPHENOL, 3,4- 000095-77-2
005318 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DICHLOROPHENOL, 3,5- 000591-35-5
005319 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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DICHLOROPHENOXY ACETIC ACID, 2,4- 000094-75-7
010265 DOW CHEMICAL CO. 1983. ACC NO. 251473.
DICHLOROPHENOXY)BUTYRIC ACID, 4-, (2,4- 000094-82-6
005890 RHODIA INC. 1969. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO. 0092165.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2,4- DB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
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DICHLOROPROPANE, 1,1- 000078-99-9
005890 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES. PREPARED BY THE OFFICE OF HEALTH AND
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EMERGENCY RESPONSE, WASHINGTON, DC.
DICHLOROPROPANE, 1,2- 000078-87-5
005898 NITSCHKE,KD,,A JOHNSON, DL WACKERLE, JE PHILLIPS AND DA DITTENBER. 1988. PROPYLENE DICHLOR1DE: A 13 WEEK INHALATION
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US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES. PREPARED BY THE OFFICE OF HEALTH AND
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DICHLOROPROPANE, 1,3- 000142-28-9
005899 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES. PREPARED BY THE OFFICE OF HEALTH AND
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EMERGENCY RESPONSE, WASHINGTON, DC.
DICHLOROPROPANE, 2,2- 000594-20-7
005900 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROPANES. PREPARED BY THE OFFICE OF HEALTH AND
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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DICHLOROPROPENE, 1,3- 000542-75-6
005901 DOW CHEMICAL CO. 1973. MRID NOS. 00067977, 0039684. US EPA, WASHINGTON, DC.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENTFOR 1,3-DICHLOROPROPENE. PREPARED BY THE OFFICE OF HEALTH AND
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010351 LOMAX, LG, WT STOTT, KA JOHNSON, ET AL. 1989. THE CHRONIC TOXICITY AND ONCOGENICITY OF INHALED TECHNICAL-GRADE
1,3-DICHLOROPROPENE IN RATS AND MICE. FUND APPL TOXICOL. 12:418-431.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1,3-DICHLOROPROPENE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DICHLORPROP 000120-36-5
005896 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DICHLOROPROP. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
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DICYCLOPENTADIENE 000077-73-6
005425 LITTON BIONETICS, INC. 1980. MAMMALIAN TOXICOLOGICAL EVALUATION OF DIMP AND DCPD, (PHASE 2). LITTON BIONETICS, INC.,
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US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYCLOPENTADIENE AND DICYCLOPENTADIENE. PREPARED BY THE OFFICE OF
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DIELDRIN 000060-57-1
005429 WALKER, AIT, DE STEVENSON, J ROBINSON, ET AL. 1969. THE TOXICOLOGY AND PHARMACODYNAMICS OF DIELDRIN (HEOD): TWO-YEAR ORAL
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DIETHYL PHTHALATE 000084-66-2
005620 BROWN, D, KR BUTTERWORTH, IF GAUNT ET AL. 1978. SHORT-TERM ORAL TOXICITY STUDY OF DIETHYL PHTHALATE IN THE RAT. FOOD COSMET
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DIETHYL-P-NITROPHENYL PHOSPHATE 000311-45-5
005922 US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR DIETHYL-P-NITROPHENYL PHOSPHATE. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
DIETHYLANILINE, N,N- 000091-66-7
005903 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N,N- DIETHYLANILINE. PREPARED BY THE OFFICE OF HEALTH AND
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DIETHYLENE GLYCOL MONOBUTYL ETHER 000112-34-5
005482 US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
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DIETHYLENE GLYCOL MONOETHYL ETHER 000111-90-0
005476 HALL, DE, FS LEE, P AUSTIN AND FA FAIRWEATHER. 1966. SHORT-TERM FEEDING STUDY WITH DIETHYLENE GLYCOL MONOETHYL ETHER IN RATS.
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ENVIRONMENTAL CRITERIA AND ASSESSMENT OFF ICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
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005478 SMYTH, HF, CP CARPENTER AND CB SHAFFER. 1964. A 2-YEAR STUDY OF DIETHYLENE GLYCOL MONOETHYL ETHER IN RATS. FOOD COSMET
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US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
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DIETHYLFORMAMIDE 000617-84-5
010437 ARGUS MF, JC ARCOS AND C HOCH-LIGETI. 1965. THE CARCINOGENIC ACTIVITY OF PROTEIN-DENATURING AGENTS: HEPATOCARCINOGENICITY OF
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US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIETHYLFORMAMIDE. PREPARED BY THE OFFICE OF HEALTH AND
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EMERGENCY RESPONSE, WASHINGTON, DC.
DIETHYLHYDRAZINE, 1,2- 001615-80-1
005921 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1,2- DIETHYLHYDRAZINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DIMETHOATE 000060-51-5
005923 AMERICAN CYANAMID COMPANY. 1986. MRID NO 00164177. US EPA, WASHINGTON DC.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHOATE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
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DIMETHYL PHTHALATE 000131-11-3
010267 LEHMAN AJ. 1955. INSECT REPELLANTS. ASSOC FOOD DRUG OFFICE, US QUART BULL. 19:87.
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OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF
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DIMETHYLANILINE, N,N- 000121-69-7
005924 ABDO K, M WOLFE AND R HILES. 1984. SUBCHRONIC TOXICITY OF N,N- DIMETHYLANILINE TO F-344 RATS AND B6C3F1 MICE. FED PROC.
43(3): 1698.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIMETHYLANILINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DIMETHYLFORMAMIDE, N,N- 000068-12-2
005925 BECCI, PJ, KA VOSS, WD JOHNSON, ET AL. 1983. SUBCHRONIC FEEDING STUDY OF N.N-DIMETHYLFORMAMIDE IN RATS AND MICE. J AM COLL
TOXICOL 2(6): 371-378.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIMETHYLFORMAMIDE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
010352 CIRLA, AM, G PISATI, E INVERNIZZI ET AL. 1984. EPIDEMIOLOGICAL STUDY ON WORKERS EXPOSED TO LOW DIMETHYLFORMAMIDE
CONCENTRATIONS. G ITAL MED LAV. 6(3-4):149-156.
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LOWER THAN THE ACTUALLY PROPOSED TLV. G ITAL MED LAV. 6(3-4):157-158.
DIMETHYLPHENOL, 2,3- 000526-75-0
005926 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DIMETHYLPHENOL, 2,4- 000105-67-9
010266 US EPA. 1989. NINETY-DAY GAVAGE STUDY IN ALBINO MICE USING 2,4-DIMETHYLPHENOL. STUDY NO. 410-2831, PREPARED BY DYNAMAC
CORPORATION, ROCKVILLE, MD, FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
DIMETHYLPHENOL, 2,5- 000095-87-4
005928 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DIMETHYLPHENOL, 2,6- 000576-26-1
005431 VELDRE, IA AND HJ JANES. 1979. TOXICOLOGICAL STUDIES OF SHALE OILS, SOME OF THEIR COMPONENTS AND COMMERCIAL PRODUCTS. ENVIRON
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US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
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DIMETHYLPHENOL, 3,4- 000095-65-8
005437 VELDRE, IA AND HJ JANES. 1979. TOXICOLOGICAL STUDIES OF SHALE OILS, SOME OF THEIR COMPONENTS AND COMMERCIAL PRODUCTS. ENVIRON
HEALTH PERSPECT 30:141-146.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR DIMETHYLPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
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DIMETHYLTEREPHTHALATE 000120-61-6
005930 NCI (NATIONAL CANCER INSTITUTE). 1979. BIOASSAY OF DIMETHYL TEREPHTHALATE FOR POSSIBLE CARCINOGENICITY. DHEW/PUB/NIH 79-1376,
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DIMETHYLUREA, N,N- 000598-94-7
005931 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N,N- DIMETHYLUREA. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DI-N-OCTYL PHTHALATE 000117-84-0
010275 PIEKACZ H. 1971. EFFECT OF DIOCTYL AND DIBUTYL PHTHALATES ON THE ORGANISM OF RATS AFTER ORAL ADMINISTRATION IN PROLONGED
EXPERIMENT. II. SUBACUTE AND CHRONIC TOXICITY. ROCZ PANSTW ZAKL HIG. 22(3): 295-307.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHTHALIC ACID, ALKYL, ARYL, AND ALKYL/ARYL ESTERS. PREPARED BY
THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE
OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
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(OTHER THAN CARCINOGENICITY) January 1992
DINITRO-0-CRESOL, 4,6- 000534-52-1
008883 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR OINITROCRESOLS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DINITRO-P-CRESOL, 2,6- 000609-93-8
005934 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2,6- DINITRO-P-CRESOL. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DINITROBENZENE, 1,2- 000528-29-0
010201 CODY TE, S WITHERUP, L HASTINGS, K STEMMER AND RT CHRISTIAN. 1981. 1,3-DINITROBENZENE: TOXIC EFFECT IN VIVO AND IN VITRO. J
TOXICOL ENVIRON HEALTH. 7(5):829-847.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROBENZENES (0-, M-, P-). PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
AND EMERGENCY RESPONSE, WASHINGTON, DC.
DINITROBENZENE, 1,3- 000099-65-0
008884 CODY TE, S WITHERUP, L HASTINGS, K STEMMER AND RT CHRISTIAN. 1981. 1,3-DINITROBENZENE: TOXIC EFFECT IN VIVO AND IN VITRO. J
TOXICOL ENVIRON HEALTH. 7(5):829-847.
DINITROBENZENE, 1,4- 000100-25-4
010202 CODY TE, S WITHERUP, L HASTINGS, K STEMMER AND RT CHRISTIAN. 1981. 1,3-DINITROBENZENE: TOXIC EFFECT IN VIVO AND IN VITRO. J
TOXICOL ENVIRON HEALTH. 7(5):829-847.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROBENZENES (0-, M-, P-). PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
AND EMERGENCY RESPONSE, WASHINGTON, DC.
DINITROPHENOL, 2,3- 000066-56-8
005936 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DINITROPHENOL, 2,4 000051-28-5
010438 HORNER WD. 1942. DINITROPHENOL AND ITS RELATION TO FORMATION OF CATARACTS. ARCH OPHTHALMOL. 27: 1097-1121.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
DINITROPHENOL, 2,5- 000329-71-5
005937 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DJNITROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DINITROPHENOL, 2,6- 000573-56-8
005938 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIN1TROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DINITROPHENOL, 3,5- 000586-11-8
005939 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROPHENOLS (SELECTED). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DINITROTOLUENE, 2,3- 000602-01-7
005940 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DINITROTOLUENE, 2,4- 000121-14-2
005941 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DINITROTOLUENE, 2,5- 000619-15-8
005942 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DINITROTOLUENE, 2,6- 000606-20-2
005943 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DINITROTOLUENE, 3,4- 000610-39-9
005944 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROTOLUENE. PREPARED BY THE OFFICE OF -HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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(OTHER THAN CARCINOGENICITY) January 1992
DINOSEB 000088-85-7
005945 DOW CHEMICAL COMPANY. 1981. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO 00152675.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINOSEB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
DIPHENYLAMINE,N,N- 000122-39-4
005946 THOMAS JO, WE RIBELIN, JR WOODWARD AND F DEEDS. 1967. THE CHRONIC TOXICITY OF DIPHENYLAMINE FOR DOGS. TOXICOL APPL PHARMACOL.
11: 184-194.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N.N-DIPHENYLAMINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DIRECT LIGHTFAST BLUE 004399-55-7
005947 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT LIGHTFAST BLUE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DISULFOTON 000298-04-4
010412 MOBAY CHEMICAL COMPANY. 1985. MRID NO. 00129456, 00146873, 41115401. AVAILABLE FROM EPA. WRITE TO FOI, EPA, WASHINGTON, DC
20460.
US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR OISULFOTON. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON DC.
ENDOSULFAN 000115-29-7
010439 AMERICAN HOESCHT. 1984. MRID NO. 00147196, 00148264. AVAILABLE FROM EPA. WRITE TO FOI, EPA, WASHINGTON, DC 20460.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ALPHA- AND 8ETA-ENDO-SULFAN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
WASHINGTON, DC.
ENDOTHALL 000145-73-3
005948 PENNWALT AGCHEM. ND MRID NO 00101735. AVAILABLE FROM US EPA. WRITE TO FOI. EPA, WASHINGTON, DC 20460.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ENDOTHALL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA ANDASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
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(OTHER THAN CARCINOGENICITY) January 1992
ENDRIN 000072-20-8
005445 VELSICOL CHEMICAL CORPORATION. 1969. MRID NO. 00030198. AVAILABLE FROM EPA. WRITE FOI, EPA, WASHINGTON DC, 20460.
US EPA. 1991. DRINKING WATER CRITERIA DOCUMENT FOR ENDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER, WASHINGTON, DC.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ENDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
DC.
EPICHLOROHYDRIN 000106-89-8
010440 LASKIN S, AR SELLAKUMAR, M KUSCHNER, ET AL. 1980. INHALATION CARCINOGENICITY OF EPICHLOROHYDRIN IN NON-INBRED SPRAGUE-DAWLEY
RATS. J NATL CANCER INST. 65(4): 751-757.
US EPA. 1984. HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RESEARCH TRIANGLE PARK, NC. EPA 600/8-83-032F. NTIS PB85-132363.
005950 QUAST JF, JW HENCK, BJ POSTMA, ET AL. 1979. EPICHLOROHYDRIN SUBCHRONIC STUDIES. I. A 90-DAY INHALATION STUDY IN LABORATORY
RODENTS. 80 SUBMISSION. MICROFICHE #206200.
US EPA. 1984. HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RESEARCH TRIANGLE PARK, NC. EPA 600/8-83-032F. NTIS PB85-132363.
905950 QUAST, JF, BJ HENCK, POSTMA, DJ SCHUETZ AND MJ MCKENNA. 1979. EPICHLOROHYDRIN - SUBCHRONIC STUDIES. I. A 90-DAY INHALATION
STUDY IN LABORATORY RODENTS (FISCHER 344 RATS, SPRAGUE-DAWLEY RATS AND B6C3F1 MICE). DOW CHEMICAL USA, MIDLAND, MI.
EPTC 000759-94-4
005959 PPG INDUSTRIES, INC. 1986. CONFIDENTIAL BUSINESS INFORMATION: UNPUBLISHED STUDY. ACCESSION NO. 263695, 262696. MRID NO.
00161597.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR EPTC. PREPARED BY THEOFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
ETHOPROP 013194-48-4
005951 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHOPROP. PREPARED BY THE OFFICE OF HEALTH AUD ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
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(OTHER THAN CARCINOGENICITY) January 1992
ETHOXYETHANOL, 2- 000110-80-5
005468 STENGER, EG, A LISLOTT, D MUELLER ET AL. 1971. TOXICOLOGY OF ETHYLENE GLYCOL MONOETHYLETHER. ARZNEIM-FORSCH 21(6): 880-885.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC. EPA 540/1-86-052.
010441 BARBEE, SJ, JB TERRILL, DJ OESOUSA AND CC CONAWAY. 1984. SUBCHRONIC INHALATION TOXICOLOGY OF ETHYLENE GLYCOL MONOETHYL ETHER
IN THE RAT AND RABBIT. ENVIRON HEALTH PERSPECT 57: 157- 163.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC. EPA 540/1-86-052.
005470 MELNICK, RL. 1984. TOXICITIES OF ETHYLENE GLYCOL AND ETHYLENE GLYCOL MONOETHYL ETHER IN FISCHER 344/N RATS AND B6C3F1 MICE.
ENVIRON HEALTH PERSPECT 57: 147-155.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2-ETHOXY-ETHANOL. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
ETHOXYETHANOL ACETATE, 2- 000111-15-9
REFER TO REFERENCES FOR HEAST TABLE 2.
ETHOXYETHANOL DODECANOATE, 2- 000106-13-8
005956 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2- ETHOXYETHANOL ESTERS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
ETHOXYETHANOL PHOSPHATED, 2- 068554-00-7 .
005955 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2- ETHOXYETHANOL ESTERS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
ETHOXYETHYL ACRYLATE, 2- 000106-74-1
005953 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2- ETHOXYETHANOL ESTERS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
ETHOXYETHYL METHACRYLATE, 2- 002370-63-0
005954 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2- ETHOXYETHANOL ESTERS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
ETHYL-0-XYLENE, 4- 000934-80-5
008882 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ETHYL BENZENES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
ETHYL ACETATE 000141-78-6
005957 US EPA. 1986. RAT ORAL SUBCHRONIC STUDY WITH ETHYL ACETATE. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYL ACETATE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
AND EMERGENCY RESPONSE, WASHINGTON, DC.
ETHYL CHLORIDE 000075-00-3
010371 SCORTICHINI BH, KA JOHNSON, JJ MOMANY-PFRUENDER ET AL. 1986. ETHYL CHLORIDE: INHALATION TERATOLOGY STUDY IN CF-1 MICE. DOW
CHEMICAL CO. EPA 86-870002248.
ETHYL ETHER 000060-29-7
010396 AMERICAN BIOGENICS CORP. 1986. 90-DAY GAVAGE STUDY IN RATS USING ETHYL ETHER. STATUS REPORT FOR ABC STUDY NO. 410-2343
3/18/86.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ETHYL ETHER. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
ETHYL METHACRYLATE 000097-63-2
005961 BORZELLECA JF, PS LARSON, GR HENNIGAR, ET AL. 1964. STUDIES ON THE CHRONIC ORAL TOXICITY OF MONOMERIC ETHYL ACRYLATE AND
METHYL METHACRYLATE. TOXICOL APPL PHARMACOL. 6: 29-36.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYL METHACRYLATE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
ETHYLANILINE, N- 000103-69-5
005958 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR N- ETHYLANILINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) January 1992
ETHYLBENZENE 000100-41-4
005447 WOLF, MA, VK ROUE, DO MCCOLLISTER, RL HOLLINGSUORTH AND F OYEN. 1956. TOXICOLOGICAL STUDIES OF CERTAIN ALKYLATED BENZENE AND
BENZENES. AMA ARCH IND HEALTH 14:387-398. CITED IN US EPA, 1985.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR ETHYLBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
DC.
US EPA 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYLBENZENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
005446 ANDREW, FD, RL BUSHCOHBOM, WC CANNON, ET AL. 1981. TERATOLOGIC ASSESSMENT OF ETHYLBENZENE AND 2-ETHOXYETHANOL. BATTELLE
PACIFIC NORTHWEST LABORATORY, RICHLAND, WA. NTIS PB83-208074. P 108.
HARDIN BD, GP BOND, MR SIKOV, ET AL. 1981. TESTING OF SELECTED WORKPLACE CHEMICALS FOR TERATOGENIC POTENTIAL. SCAND J WORK
ENVIRON HEALTH 7:66-75.
ETHYLENE CYANOHYDRIN 000109-78-4
005780 SAUERHOFF, MW, WH BRAUN, JC RAMSEY ET AL. 1976. TOXICOLOGICAL EVALUATION AND PHARMACOKINETIC PROFILE OF B-
HYDROXYPROPIONITRILE IN RATS. J. TOXICOL. ENVIRON. HEALTH. 2(1): 31-44.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
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ETHYLENE DIAMINE 000107-15-3
005796 YANG, RS, RH CARMAN, RR MARONPOT, ET AL. 1983. ACUTE AND SUBCHRONIC TOXICITY OF ETHYLENEDIAMINE IN LABORATORY ANIMALS. FUND
APPL TOXICOL 3(6):512-520
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR ETHYLENEDIAMINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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(OTHER THAN CARCINOGENICITY) January 1992
ETHYLENE GLYCOL 000107-21-1
005452 MARONPOT, RR, JP ZELENAK, EV WEAVER AND NJ SMITH. 1983. TERATOGENICITY STUDY OF ETHYLENE GLYCOL IN RATS. DRUG CHEM TOXICOL
6(6): 579-594.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ETHYLENE GLYCOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
DC.
005454 DEPASS, LR, RH GARMAN, MD WOODSIDE ET AL. 1986. CHRONIC TOXICITY AND ONCOGENICITY STUDIES OF ETHYLENE GLYCOL IN RATS AND
MICE. FUND APPL TOXICOL 7:547-565.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR ETHYLENE GLYCOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
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ETHYLENE GLYCOL MONOBUTYL ETHER 000111-76-2
010353 DODD DE, WM SWELLINGS, RR MAROMPOT, ET AL. 1983. ETHYLENE GLYCOL MONOBUTYL ETHER: ACUTE, 9-DAY AND 90-DAY VAPOR INHALATION
STUDIES IN FISCHER 344 RATS. TOXICOL APPL PHARMACOL 68:405-414.
ETHYLENE THIOUREA 000096-45-7
010397 GRAHAM SL, KJ DAVIS, WH HANSEN AND CH GRAHAM. 1975. EFFECTS OF PROLONGED ETHYLENE THIOUREA INGESTION ON THE THYROID OF
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ETHYLTOLUENE, M- 000620-14-4
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ETHYLTOLUENE, 0- 000611-14-3
005962 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ETHYL BENZENE. PREPARED BY THE OFFICE OF HEALTH AND
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FLUORANTHENE 000206-44-0
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FLURIDONE 059756-60-4
005966 ELANCO PRODUCTS COMPANY, DIVISION OF ELI LILLY AND COMPANY. 1980. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY.
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005967 CHEVRON CHEMICAL CORPORATION. 1986. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 263772. MRID NO.
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ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
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FORMALDEHYDE 000050-00-0
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FORMALDEHYDE CYANOHYDRIN 000107-16-4
005782 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CYANOHYDRINS. PREPARED BY THE OFFICE OF HEALTH AND
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005466 SRI (SOUTHERN RESEARCH INSTITUTE). 1981. 90 DAY RAT REPORT. UNPUBLISHED STUDY PERFORMED FOR NTP.
GLYCIDALDEHYDE 000765-34-4
005968 HINE CH, RJ GUZMAN, MK DUNLAP, R LIMA AND GS LOQUVAM. 1961. STUDIES ON THE TOXICITY OF GLYCIDALDEHYDE. ARCH ENVIRON HEALTH.
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010399 DOW CHEMICAL CO. 1958. MRID NO 00061912. AVAILABLE FROM EPA. WRITE TO FOI, EPA, WASHINGTON, DC 20460.
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005514 KOCIBA, RJ, DG KEYS, GC JERSEY, ET AL. 1977. RESULTS OF A 2-YEAR CHRONIC TOXICITY STUDY WITH HEXACHLOROBUTADIENE IN RATS.
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HEXACHLOROCYCLOHEXANE, GAMMA- 000058-89-9
005537 ZOECON CORPORATION. 1983. MRID NO 00128356. AVAILABLE UNDER FOI, EPA, WASHINGTON, DC, 20460.
HEXACHLOROCYCLOPENTADIENE 000077-47-4
0010445 BATTELLE NORTHWEST LABORATORIES. 1984. INHALATION CARCINOGENESIS BIOASSAY STUDY: SUBCHRONIC STUDY REPORT ON
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ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL
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HEXACHLOROETHANE IN THE RAT. DRUG CHEM TOXICOL 8(3): 155-169.
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HEXACHLOROPHENE 000070-30-4
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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HEXAMETHYLENE DIAMINE 000124-09-4
005973 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR HEXAMETHYLENEDIAMINE. PREPARED BY THE OFFICE OF HEALTH AND
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THEIR METABOLITES. TOXICOL APPL PHARMACOL. 52(3): 433-441.
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ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
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010273 SANAGI S, Y SEKI, K SUGIMOTO AND M HIRATA. 1980. PERIPHERAL NERVOUS SYSTEM FUNCTIONS OF WORKERS EXPOSED TO N-HEXANE AT A
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005976 US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR N- HEXANONE. PREPARED BY THE OFFICE OF HEALTH AND
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HYDROGEN SULFIDE 007783-06-4
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HYDROQUINONE 000123-31-9
005526 CARLSON, AJ AND NR BREWER. 1953. TOXICITY STUDIES ON HYDROQUINONE. PROC SOC EXP BIOL MED 84: 684-688.
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ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
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IRON 007439-89-6
005527 US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR IRON (AND COMPOUNDS). PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
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ISOBUTYL ALCOHOL 000078-83-1
005977 US EPA. 1986. RAT ORAL SUBCHRONIC TOXICITY WITH ISOBUTYL ALCOHOL. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON,
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ISOPHORONE 000078-59-1
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ISOPROPALIN 033820-53-0
005978 ELANCO PRODUCTS COMPANY. 1969. CONFIDENTIAL BUSINESS INFORMATION. UNPUBLISHED STUDY. MRIO NO. 00002472.
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LACTONITRILE 000078-97-7
005783 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES. PREPARED BY THE OFFICE OF HEALTH AND
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THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE WASHINGTON DC.
LEAD 007439-92-1
010447 REFER TO IRIS.
910447 REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS
LEAD ALKYLS
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MALATHION 000121-75-5
005991 MOELLER HC AND JA RIDER. 1962. PLASMA AND RED BLOOD CELL- CHOLINESTERASE ACTIVITY AS INDICATIONS OF THE THRESHOLD OF
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005993 UNIROYAL CHEMICAL CO. 1981. ACCESSION NO. 250523.
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005995 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MANCOZEB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
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DISEASE IN RATS. CLIN IMMUNOL IMMUNOPATHOL 20:129-135.
DRUET P, E DRUET, F POTDEVIN, C SAPIN. 1978. IMMUNE TYPE GLOMERULONEPHRITIS INDUCED BY HG CL2 IN THE BROWN NORWAY RAT. ANN IMMUNOL.
129C:777-792.
US EPA. 1987. PEER REVIEW WORKSHOP ON MERCURY ISSUES. OCTOBER 26-27, 1987. SUMMARY REPORT. ENVIRONMENTAL CRITERIA AND ASSESSMENT
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MERPHOS 000150-50-5
005998 ABOU-DONIA MB, DG GRAHAM PR TIMMONS AND BL REICHERT. 1980. LATE ACUTE, DELAYED NEUROTOXIC AND CHOLINERGIC EFFECTS OF S,S,S-
TRIBUTYLPHOSPHOROTRITHIOITE (MERPHOS) IN HENS. TOXICOL APPL PHARMACOL. 53: 439-457.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MERPHOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
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MERPHOS OXIDE 000078-48-8
005999 ABOU-DONIA MB, DG GRAHAM, KM ABDO AND AA KOMEIL. 1979. DELAYED NEUROTOXIC, LATE ACUTE AND CHOLINERGIC EFFECTS OF S,S,S-
TRIBUTYLPHOSPHOROTRITHIOATE (DEF): SUBCHRONIC (90 DAYS) ADMINISTRATION IN HENS. TOXICOLOGY. 14: 229-243.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR MERPHOS OXIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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METHACRYLONITRILE 000126-98-7
005812 POZZANI, UC, CR KINKEAD AND JM KING. 1968. THE MAMMALIAN TOXICITY OF METHACRYLONITRILE. AM IND HYG ASSOC J 29(3):202-210.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES, PREPARED BY THE OFFICE OF HEALTH AND
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METHANOL 000067-56-1
010271 US EPA. 1986. RAT ORAL SUBCHRONIC TOXICITY STUDY WITH METHANOL. OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE. WASHINGTON, DC.
METHOMYL 016752-77-5
005802 E.I. DU PONT DE NEMOURS AND COMPANY, INC. 1968. MRID NO. 00007091, 00009012.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR METHOMYL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
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METHOXYCHLOR 000072-43-5
010357 KINCAID ENTERPRISES, INC. 1986. MRID NO 0015992. AVAILABLE FROM EPA. WRITE TO FOI, EPA, WASHINGTON, DC 20460.
METHOXYETHANOL, 2- 000109-86-4
010372 MILLER RR, LL CALHOUN, BL YANO. 1982. ETHYLENE GLYCOL MONOMETHYL ETHER. 13-WEEK VAPOR INHALATION STUDY IN MALE RABBITS.
REPORT PREPARED FOR THE CMA MARCH 25, 1982.
MILLER RR, JA AYRES, JL YOUNG, ET AL. 1983. ETHYLENE GLYCOL MONOMETHYL ETHER. I. SUBCHRONIC VAPOR INHALATION STUDY WITH RATS
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METHYL ACETATE 000079-20-9
010002 TOXICITY RESEARCH LABORATORY. 1986. RAT ORAL SUBCHRONIC TOXICITY STUDY WITH METHANOL. SPONSORED BY OFFICE OF SOLID WASTE AND
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METHYL ACRYLATE 000096-33-3
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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METHYL CHLOROCARBONATE 000079-22-1
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METHYL ETHYL KETONE 000078-93-3
005558 LABELLE, CW AND H BRIEGER. 1955. VAPOUR TOXICITY OF A COMPOSITE SOLVENT AND ITS PRINCIPAL COMPONENTS. ARCH IND HEALTH 12:
623- 627.
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METHYL ISOBUTYL KETONE 000108-10-1
005563 MICROBIOLOGICAL ASSOCIATES. 1986. SUBCHRONIC TOXICITY OF METHYL ISOBUTYL KETONE IN SPRAGUE-DAWLEY RATS. PRELIMINARY REPORT
FOR RESEARCH TRIANGLE INSTITUTE, RTP, NC STUDY NO 5221.04 JANUARY.
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METHYL ISOCYANATE 000624-83-9
010013 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL ISOCYANATE. PREPARED BY THE OFFICE OF HEALTH AND
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METHYL MERCURY 022967-92-6
005547 CLARKSON, TW, L AMIN-ZAKI, SK AL-TIKRITI. 1976. AN OUTBREAK OF METHYL MERCURY POISONING DUE TO CONSUMPTION OF CONTAMINATED
GRAIN. FEDERATION PROCEEDINGS. 35(12):2395-2399.
NORDBERG, GF, P STRANGERT. 1976. ESTIMATIONS OF A DOSE-RESPONSE CURVE FOR LONG-TERM EXPOSURE TO METHYLMERCURIC COMPOUNDS IN
HUMAN BEINGS TAKING INTO ACCOUNT VARIABILITY OF CRITICAL ORGAN CONCENTRATIONS AND BIOLOGICAL HALF- TIME: A PRELIMINARY
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WHO (WORLD HEALTH ORGANIZATION). 1976. ENVIRONMENTAL HEALTH CRITERIA FOR MERCURY. IN: ENVIRONMENTAL HEALTH CRITERIA 1. WHO,
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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010014 BORZELLECA JF, PS LARSON, GR HENNIGAR, ET AL. 1964. STUDIES ON THE CHRONIC ORAL TOXICITY OF MONOMER 1C ETHYL ACRYLATE AND
METHYL METHACRYLATE. TOXICOL APPL PHARMACOL. 6: 29-36.
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METHYL PARATHION 000298-00-0
010015 MONSANTO CO. 1984. ACCESSION NO 252501-252503, 253346, 253372- 253374. MRID NO. 000139023, 00143965, 00145507. US EPA,
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METHYL STYRENE, ALPHA- 000098-83-9
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METHYL STYRENE (MIXED ISOMERS) 025013-15-4
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ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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METHYLCYCLOHEXANE 000108-87-2
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METHYLENE-BIS(2-CHLOROANILINE), 4,4'- 000101-14-4
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005553 NATIONAL COFFEE ASSOCIATION. 1982. 24-MONTH CHRONIC TOXICITY AND ONCOGENICITY STUDY OF METHYLENE CHLORIDE IN RATS FINAL
REPORT. PREPARED BY HAZLETON LABORATORIES AMERICA, INC., VIENNA, VA. UNPUBLISHED
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METHYLENEDIPHENYL ISOCYANATE, 4,4'- 000101-68-8
010449 REUZEL PGJ, JHG ARTS, MHM KUYPERS, ET AL. 1990. CHRONIC TOXICITY/CARCINOGENICITY INHALATION STUDY OF POLYMERIC
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MIREX 002385-85-5
005569 SHANNON, VC. 1976. THE EFFECTS OF MIREX ON THE REPRODUCTIVE PERFORMANCE AND BEHAVIORAL DEVELOPMENT IN THE PRAIRIE VOLE
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MOLINATE 002212-67-1
010017 STAUFFER CHEMICAL COMPANY. 1981. MRID NO 00079209. US EPA, WASHINGTON, DC.
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910414 KOLVAL'SKIY, W, GA YAROVAYA AND DM SHMAVONYAN. 1961. CHANGES OF PURINE METABOLISM IN MAN AND ANIMALS UNDER CONDITIONS OF
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NAPHTHALENE 000091-20-3
010446 NTP (NATIONAL TOXICOLOGY PROGRAM). 1980. UNPUBLISHED SUBCHRONIC TOXICITY STUDY: NAPHTHALENE (C52904), FISHER 344 RATS.
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NAPHTHOQUINONE, 1,4- 000130-15-4
010020 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1,4- NAPHTHOQUINONE. PREPARED BY THE OFFICE OF HEALTH AND
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
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NICKEL (METALLIC) 007440-02-0
005579 AMBROSE, AM, OS LARSON, JR BORZELLECA AND GR HENNIGAR, JR. 1976. LONG-TERM TOXICOLOGIC ASSESSMENT OF NICKEL IN RATS AND DOGS.
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NICOTINONITRILE 000100-54-9
005584 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES. PREPARED BY THE OFFICE OF HEALTH AND
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NITRIC OXIDE 010102-43-9
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010021 WALTON G. 1951. SURVEY OF LITERATURE RELATING TO INFANT METHEMOGLOBINEMIA DUE TO NITRATE-CONTAMINATED WATER. AM J PUB
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ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
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NITROANILINE, M- 000099-09-2
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EMERGENCY RESPONSE, WASHINGTON, DC.
010400 US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 3- NITROANILINE. PREPARED BY THE OFFICE OF HEALTH AND
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NITROANILINE, 0- 000088-74-4
010022 BIODYNAMICS. 1983a. A FOUR-WEEK INHALATION STUDY OF ORTHO-NITROANILINE IN HALE RATS. FINAL REPORT. SUBMITTED BY MONSANTO
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BIOOYNAMICS. 1983b. A FOUR-WEEK INHALATION TOXICITY STUDY OF 0-NITROANILINE IN THE RAT. FINAL REPORT. SUBMITTED BY
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ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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NITROBENZENE 000098-95-3
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US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR NITROFURANS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
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NITROGEN DIOXIDE 010102-44-0
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NITROMETHANE 000075-52-5
010026 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROMETHANE. PREPARED BY THE OFFICE OF HEALTH AND
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NITROPHENOLS
005594 US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR NITROPHENOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
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NITROPROPANE,.2- 000079-46-9
010374 ANGUS CHEMICAL CO. 1985. FINAL REPORT: CHRONIC INHALATION EXPOSURE TO RATS TO VAPORS OF 2-NITROPROPANE AT 100 PPM. PREPARED
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ANGUS CHEMICAL CO. 1985. CHRONIC INHALATION OF 200 PPM OF 2-NITROPROPANE IN RATS. PREPARED BY COULSTON INTERNATIONAL CORP
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NITROTOLUENE, M- 000099-08-1
010029 CISS M, N HUYEN, H DUTERTRE, N PHU-LICH AND R TRUHAUT. 1980. TOX1COLOGICAL STUDY OF NITROTOLUENES: LONG-TERM TOXICITY.
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NITROTOLUENE, 0- 000088-72-2
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OCTABROMODIPHENYL ETHER 032536-52-0
010032 CARLSON GP. 1980. INDUCTION OF XENOBIOTIC METABOLISM IN RATS BY BROMINATED DIPHENYL ETHERS ADMINISTERED FOR 90 DAYS.
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OCTAMETHYLPYROPHOSPHORAMIDE 000152-16-9
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OZONE 010028-15-6
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PARALDEHYDE 000123-63-7
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PARTICULATE MATTER
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PENTABROMODIPHENYL ETHER 032534-81-9
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PHENANTHRENE 000085-01-8
005604 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PHENANTHRENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
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POTASSIUM CYANIDE 000151-50-8
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005486 ROWE, VIC, DD MCCOLLISTER, HC SPENCER, ET AL. 1954. TOXICOLOGY OF MONO-, DI-, AND TRI-PROPYLENE GLYCOL METHYL ETHERS. ARCH IND
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US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR GLYCOL ETHERS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE.
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PROPYLENE OXIDE 000075-56-9
010375 KUPER CF, PGJ REUZEL, VJ FERON, ET AL. 1988. CHRONIC INHALATION TOXICITY AND CARCINOGENICITY OF PROPYLENE OXIDE IN WISTAR
RATS. FOOD CHEM TOXICOL 26(2):159-167.
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ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
PYRENE 000129-00-0
010176 US EPA. 1989. MOUSE ORAL SUBCHRONIC TOXICITY STUDY OF PYRENE. STUDY CONDUCTED BY TOXICITY RESEARCH LABORATORIES, MUSKEGON, MI
FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR PYRENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
DC.
PYRIDINE 000110-86-1
010055 US EPA. 1986. PYRIDINE. 90-DAY SUBCHRONIC ORAL TOXICITY IN RATS. SPONSORED BY OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR PYRIDINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
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(OTHER THAN CARCINOGENICITY) January 1992
RDX (CYCLONITE) 000121-82-4
010056 US DEPARTMENT OF DEFENSE. 1983. AD-A160-774.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR RDX (CYCLONITE). PREPARED BY THE OFFICE OF HEALTH AND
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RONNEL 000299-84-3
010057 MCCOLLISTER DD, F OYEN AND VK ROWE. 1959. TOXICOLOGICAL STUDIES OF 0,0-DIMETHYL-0-(2,4,5-TRICHLOROPHENYL)PHOSPHOTH10ATE
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US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR RONNEL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
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SELENOUREA 000630-10-4
008880 YANG C, S WANG, R ZHOU, AND S SUN. 1983. ENDEMIC SELENIUM INTOXICATION OF HUMANS IN CHINA. AM. J. CLIN. NUTRI. 36: 872-888.
SELENIOUS ACID 007783-00-8
010415 YANG C, S YIN, L ZHOU, ET AL. 1989. STUDIES OF SAFE MAXIMAL DAILY DIETARY SE-INTAKE IN A SELENIFERGUS AREA IN CHINA. II.
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TRACE ELEM. ELECTROLYTE SHEALTH DIS. 3: 123-130
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SELENIUM 007782-49-2
010404 YANG C, S YIN, L ZHOU, ET AL. 1989. STUDIES OF SAFE MAXIMAL DAILY DIETARY SE-INTAKE IN A SELENIFEROUS AREA IN CHINA. II.
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J TRACE ELEM ELECTROLYTES HEALTH DIS. 3: 123-130.
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SILVER 007440-22-4
010453 GAUL LE AND AN STAUD. 1935. CLINICAL SPECTROSCOPY. SEVENTY CASES OF GENERALIZED ARGYRIA FOLLOWING ORGANIC AND COLLOIDAL
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SILVER CYANIDE 000506-64-9
010283 HOWARD JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. AGRIC FOOD CHEM. 3: 325-329.
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SIMAZINE 000122-34-9
010177 CIBA-GEIGY CORPORATION. 1988. MRID N-40614405.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR SIMAZINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
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SODIUM CYANIDE 000143-33-9
005640 HOWARD, JW AND RF HANZAL. 1955. CHRONIC TOXICITY FOR RATS OF FOOD TREATED WITH HYDROGEN CYANIDE. J AGRIC FOOD CHEM 3:
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SODIUM DIETHYLDITHIOCARBAMATE 000148-18-5
005644 SUNDERMAN, FW, OE PAYNTER AND RB GEORGE. 1967. THE EFFECTS OF THE PROTRACTED ADMINISTRATION OF THE CHELATING AGENT, SODIUM
DIETHYLDITHIOCARBAMATE (DITHIOCARB). AM J MED SCI 254: 46-56.
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SODIUM METAVANADATE 013718-26-8
005735 DOMINGO, JL, JL LLOBET, JM TOMAS AND J CORBELLA. 1985. SHORT- TERM TOXICITY STUDIES OF VANADIUM IN RATS. J APPL TOXICOL 5(6):
418-421.
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(OTHER THAN CARCINOGENICITY) January 1992
STRONTIUM, STABLE 007440-24-6
010405 MARIE PJ, MT GARBA, M HOTT AND L MIRAVET. 1985. EFFECT OF LOW DOSES OF STABLE STRONTIUM ON BONE METABOLISM IN RATS.
MINER ELECTROLYTE METAB. 11: 5-13.
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010406 SKORYNA SC. 1981. EFFECTS OF ORAL SUPPLEMENTATION WITH STABLE STRONTIUM. CAN MED ASSOC J. 125:703-712.
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STRYCHNINE 000057-24-9
010285 SEIDL I AND G ZBINDEN. 1982. SUBCHRONIC ORAL TOXICITY OF STRYCHNINE IN RATS. ARCH TOXICOL. 51(3): 267-271.
STYRENE 000100-42-5
010059 QUAST JF, CG HUMISTON, RT KALNINS, ET AL. 1979. RESULTS OF A TOXICITY STUDY OF MONOMERIC STYRENE ADMINISTERED TO BEAGLE DOGS
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ASSESSMENT,.ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON, DC.
US EPA. 1989. HEALTH EFFECTS ASSESSMENT FOR STYRENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
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SUCCINONITRILE 000110-61-2
005585 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR SELECTED NITRILES. PRPEPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
SULFUR OXIDES
910059 REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
SULFUR DIOXIDES 007446-09-5
905585 REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
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(OTHER THAN CARCINOGENICITY) January 1992
SULFURIC ACID 007664-93-9
005647 CARSON, BL, BL HERNOON, HV ELLIS III, ET AL. 1981. SULFURIC ACID HEALTH EFFECTS. PREPARED UNDER CONTRACT 68-03-2928 BY
MIDWEST RESEARCH INSTITUTE, KANSAS CITY, MO. PREPARED FOR EMISSION CONTROL TECHNOLOGY DIVISION, OFFICE OF MOBILE SOURCE AIR
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US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR SULFURIC ACID. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
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TEMEPHOS ' 003383-96-8
010060 GAINES TB, RD KIMBROUGH AND ER LAW, JR. 1967. TOXICOLOGY OF ABATE IN LABORATORY ANIMALS. ARCH ENVIRON HEALTH. 14: 283-288.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TEMEPHOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
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TERBUFOS 013071-79-9
010408 MORGAREIDGE K, S SISTNER, M DANIELS, ET AL. 1973. FINAL REPORT: SIX-MONTH FEEDING STUDY IN DOGS ON AC-92,100. LABORATORY
NO. 1193. FEBRUARY 14. UNPUBLISHED STUDY. FOOD AND DRUG LABORATORIES, INC. MRID NO. 41139.
US EPA. 1987. HEALTH ASSESSMENT DOCUMENT FOR TERBUFOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
DC.
TEREPHTHALIC ACID 000100-21-0
008881 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TEREPHTHALIC ACID. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
TETRACHLOROAZOXYBENZENE 021232-47-3
010064 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCAB, TCAOB AND TCHB. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
TETRACHLOROBENZENE, 1,2,4,5- 000095-94-3
010286 CHU I, DC VILLENEUVE, VE VALLI AND VE SECOURS. 1984. TOXICITY OF 1,2,3,4-, 1,2,3,5- AND 1,2,4,5-TETRACHLOROBENZENE IN THE
RAT: RESULTS OF A 90-DAY FEEDING STUDY. DRUG CHEM TOXICOL. 7: 113-127.
TETRACHLOROCYCLOPENTADIENE 000695-77-2
005303 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED CYCLOPENTADIENES. PREPARED BY
THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT. ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR
THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
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(OTHER THAN CARCINOGENICITY) January 1992
TETRACHLOROETHANE, 1,1,1,2- 000630-20-6
010407 NTP (NATIONAL TOXICOLOGY PROGRAM). 1983. CARCINOGENESIS STUDIES OF 1,1,1,2-TETRACHLOROETHANE IN F344/N RATS AND B6C3F1
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TETRACHLOROETHYLENE 000127-18-4
005650 BUBEN, JA, EJ 0'FLAHERTY. 1985. DELINEATION OF THE ROLE OF METABOLISM IN THE HEPATOTOXICITY OF TRICHLOROETHYLENE AND
PERCHLOROETHYLENE: A DOSE-EFFECT STUDY. TOXICOL APPL PHARMACOL 78:105-122.
TETRACHLOROHYDRAZOBENZENE 071753-42-9
010065 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCAB, TCAOB AND TCHB. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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TETRACHLOROPHENOL, 2,3,4,6- 000058-90-2
005323 US EPA. 1986. 2,3,4,6-TETRACHLOROPHENOL. 90-DAY SUBCHRONIC ORAL TOXICITY STUDY IN RATS. OFFICE OF SOLID WASTE AND EMERGENCY
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TETRACHLOROPHENOL, 2,3,4,5- 004901-51-3
005324 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROINATED PHENOLS. PREPARED BY
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TETRACHLOROPHENOL, 2,3,5,6- 000935-95-5
005325 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY
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THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
TETRACHLOROPROPENE, 1,1,2,3- 010436-39-2
010066 US EPA. 1983. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROPROPENES. PREPARED BY THE OFFICE OF HEALTH AND
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TETRACHLORVINPHOS 000961-11-5
010067 SHELL CHEMICAL COMPANY. 1968. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. ACCESSION NO 115684.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STIROFOS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
TETRAETHYL DITHIOPYROPHOSPHATE 003689-24-5
010287 KIMMERLE G AND OR KLIMMER. 1974. ACUTE AND SUBCHRONIC TOXICITY OF SULFOTEP. ARCH TOXICOL. 33(1): 1-16.
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(OTHER THAN CARCINOGENICITY)
January 1992
THALLIC OXIDE 001314-32-5
005660 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CAS NO. 7446-18-6) IN SPRAGUE-DAULEY RATS. FINAL REPORT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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THALLIUM (I) ACETATE 000563-68-8
005664 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CAS NO. 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL REPORT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
THALLIUM (I) CARBONATE 006533-73-9
005668 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CAS NO. 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL REPORT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
THALLIUM (I) CHLORIDE 007791-12-0
005672 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CAS NO. 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL REPORT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
THALLIUM (IN SOLUBLE SALTS)
010458 US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
THALLIUM(I) NITRATE
010102-45-1
005676 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CAS NO. 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL
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WASHINGTON, DC.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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(OTHER THAN CARCINOGENICITY) January 1992
THALLIUM SELENITE 012039-52-0
005680 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CAS NO. 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL REPORT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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THALLIUM (I) SULFATE 007446-18-6
005682 US EPA. 1986. SUBCHRONIC (90 DAY) TOXICITY OF THALLIUM (I) SULFATE (CAS NO. 7446-18-6) IN SPRAGUE-DAWLEY RATS. FINAL REPORT.
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1988. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THALLIUM AND COMPOUNDS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
THIOCYANOMETHYLTHIO)-BENZOTHIAZOLE,2-( (TCMTB) 021564-17-0
010068 US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TCMTB. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
THIOFANOX 039196-18-4
010069 US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR THIOFANOX. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
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ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL
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(CAS NO 75-35-4) IN F344 RATS AND B6C3F1 MICE (GAVAGE STUDY). NTP TECH REP SER NO 228, DHHS NO NIH 82-1784.
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REMEDIAL RESPONSE, WASHINGTON, DC.
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RESEARCH ON INDUSTRIAL CARCINOGENESIS, VOL 3, C. MALTONI AND M. MEHLMAN, ED, PRINCETON SCIENTIFIC PUBLISHERS, PRINCETON, NJ.
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(PROPYLENE DICHLORIDE). (CAS NO. 78-87-5) IN F344/N RATS AND B6C3F1 MICE (GAVAGE STUDIES). NTP-82-092, NIH PUBL NO
84-2519, NTP TR 263. US DHHS, PHS, NIH. AUGUST, 1986 DRAFT.
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MICE. (GAVAGE STUDIES) US DEPT HEALTH AND HUMAN SERVICES, TECHNICAL REPORT SER NO. 269. NIH PUBL. NO. 85-2525.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 1,3-DICHLOROPROPENE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
010104 LOMAX LG, WT STOTT, KA JOHNSON, LL CALHOUN, BL YANO AND JF QUASI. 1989. THE CHRONIC TOXICITY AND ONCOGENICITY OF INHALED
TECHNICAL GRADE 1,3-DICHLOROPROPENE IN RATS AND MICE. FUND APPL TOXICOL. 12: 418-431.
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ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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DAVIS, KJ. 1965. PATHOLOGY REPORT ON MICE FED ALDRIN, DIELDRIN, HEPTACHLOR OR HEPTACHLOR EPOXIDE FOR TWO YEARS. INTERNAL
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010296 GASS, ET AL. 1964. CARCINOGENIC DOSE-RESPONSE CURVE TO ORAL DIETHYLSTILBESTEROL. J. NATL. CACER INST. 33:971-977.
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010106 SELLAKUMAR AR, R MONTESANO AND A SAFFIOTI. 1969. AROMATIC AMINES CARCINOGENICITY IN HAMSTERS. PROC AM ASSOC CANCER RES.
10: 78.
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN 1CITY January 1992
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010108 WEISBURGER EK, AB RUSSFIELD, F HOMBURGER, ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES
FOR LONG-TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2,4- DIMETHYLANILINE AND 2,4-DIMETHYLANILINE HYDROCHLORIDE.
PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE. CINCINNATI, OH
FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC. .
DIMETHYLANILINE, 2,4- 000095-68-1
010107 WEISBURGER EK, AB RUSSFIELD, F HOMBURGER, ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES
FOR LONG-TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2: 325-356.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2,4- DIMETHYLANILINE AND 2,4-DIMETHYLANILINE HYDROCHLORIDE.
PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH
FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
DIMETHYLBENZ[A]ANTHRACENE, 7,12- 000057-97-6
010297 FOR RCRA ACTIVITIES ONLY, CONTACT STEVE KRONER OF THE OFFICE OF SOLID WASTE (FTS 382-5219 OR 202-382-5219) FOR RCRA APPROVED
NUMERIC ASSESSMENT FOR THIS COMPOUND.
DIMETHYLBENZIDINE, 3,3'- 000119-93-7
010109 GRISWOLD DP JR, AE CASEY, EK WEISBURGER AND JH WEISBURGER. 1968. THE CARCINOGENICITY OF MULTIPLE INTRAGASTRIC DOSES OF
AROMATIC AND HETEROCYCLIC NITRO OR AMINO DERIVATIVES IN YOUNG FEMALE SPRAGUE- DAWLEY RATS. CANCER RES. 28(5): 924-933.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 3,3'- DIMETHYLBENZIDINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 3: CARCIN06ENICITY January 1992
DIMETHYLHYDRAZINE, 1,1- 000057-14-7
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DAYTON, OH.
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010110 TOTH B. 1972. COMPARATIVE STUDIES WITH HYDRAZINE DERIVATIVES. CARCINOGENICITY OF 1,1-DIMETHYLHYDRAZINE, UNSYMMETRICAL
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US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 1,1- DIMETHYLHYDRAZINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
DIMETHYLHYDRAZINE, 1,2- 000077-78-1
009993 TOTH B AND K PATEL. 1982. CARCINOGENICITY DOSE-RESPONSE STUDY BY CONTINUOUS ADMINISTRATION OF 1,2-DIMETHYLHYDRAZINE
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84:69-86.
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DIMETHYL SULFATE 000077-78-1
010112 US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIMETHYL SULFATE. PREPARED BY THE OFFICE OF HEALTH AND
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EXPOSURE. PART I. 2,4-DINITROTOLUENE. NTIS AD-A077692. 281 P.
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ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND
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005068 ELLIS HV, SH HAGUESEN, JR JOOGSON, ET AL. 1979. MAMMALIAN TOXICITY OF MUNITION COMPOUNDS. PHASE III. EFFECTS OF LIFETIME
EXPOSURE. PART I. 2,4-DINITROTOLUENE. NTIS AD-A077692. 281 P.
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ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
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DIOXANE, 1,4- 000123-91-1
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SER NO 92. DHEW PUBL NO (NIH) 78-1342.
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ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
WASHINGTON, DC.
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ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR 1,2-DIPHENYLHYDRAZINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER REGULATIONS
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DIRECT BLACK 38 001937-37-7
010113 NCI (NATIONAL CANCER INSTITUTE). 1978. 13-WEEK SUBCHRONIC TOXICITY STUDIES ON DIRECT BLUE 6, DIRECT BLACK 38 AND DIRECT
BROWN 95 DYES. NCI CARCINOGENESIS TECH REP SER NO. 108. P 127.
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ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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DIRECT BLUE 6 002602-46-2
010114 NCI (NATIONAL CANCER INSTITUTE). 1978. 13-WEEK SUBCHRONIC TOXICITY STUDIES OF DIRECT BLUE 6, DIRECT BLACK 38, AND DIRECT
BROUN 95 DYES. NCI CARCINOGENESIS. TECH REP SER NO. 108. P 127.
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ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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DIRECT BROWN 95 016071-86-6
010115 NCI (NATIONAL CANCER INSTITUTE). 1978. 13-WEEK SUBCHRONIC TOXICITY STUDIES OF DIRECT BLUE 6, DIRECT BLACK 38, AND DIRECT
BROWN 95 DYES. NCI CARCINOGENESIS. TECH REP SER NO. 108. P 127.
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ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
DIRECT SKY BLUE 6B 002610-05-1
010116 US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DIRECT SKY BLUE 6B. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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EPICHLOROHYDRIN 000106-89-8
010198 KONISHI.T, A KAWABATA, A DENDA, ET AL. 1980. FORESTOMACH TUMORS INDUCED BY ORALLY ADMINISTERED EPICHLOROHYDRIN IN MALE
WISTAR RATS. GANN 71:922-923.
US EPA. 1984. HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RESEARCH TRIANGLE PARK, NC. EPA 600/8-83-032F. NTIS PB85-132363.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR EPICHLOROHYDRIN. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
010117 LASKIN S, AR SELLAKUMAR, M KUSCHNER, ET AL. 1980. INHALATION CARCINOGENICITY OF EPICHLOROHYDRIN IN NONINBRED
SPRAGUE-DAWLEY RATS. J NATL CANCER INST. 65(4): 751-757.
US EPA. 1984. HEALTH ASSESSMENT DOCUMENT FOR EPICHLOROHYDRIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RESEARCH TRIANGLE PARK, NC. EPA 600/8-83-032F. NTIS PB85-132363.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR EPICHLOROHYDRIN. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI. OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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010118 NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. CARCINOGENESIS STUDIES OF ETHYL ACRYLATE IN F344/N RATS AND B6C3F1 NICE (GAVAGE
STUDIES).
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR ETHYL ACRYLATE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
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ETHYLENE OXIDE 000075-21-8
010422 SNELLINGS WM, CS WEIL AND RR MORONPOT. 1981. FINAL REPORT, ETHYLENE OXIDE, TWO YEAR INHALATION STUDY. SUBMITTED TO THE US
ENVIRONMENTAL PROTECTION AGENCY BY BUSHEY RUN RESEARCH CENTER, PITTSBURGH PA.
US EPA. 1985. HEALTH ASSESSMENT DOCUMENT FOR ETHYLENE OXIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, RESEARCH TRIANGLE PARK, NC. EPA 600/8-84-009F. NTIS PB86-102597.
010421 DUNKELBERG H. 1982. CARCINOGEN I CITY OF ETHYLENE OXIDE AND 1,2- PROPYLENE OXIDE UPON INTRAGASTRIC ADMINISTRATION TO RATS.
BR J CANCER. 46: 924-933.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR OXIRANE. DRAFT. ECAO-CIN-P071. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
AND EMERGENCY RESPONSE, WASHINGTON, DC.
ETHYLENE THIOUREA 000096-45-7
010423 NTP (NATIONAL TOXICOLOGY PROGRAM). 1989. NTP TECHNICAL REPORT ON THE PERINATAL TOXICITY AND CARCINOGENICITY STUDIES OF
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US EPA. 1989. EBDC SPECIAL REVIEW TECHNICAL SUPPORT DOCUMENT. OFFICE OF PESTICIDE PROGRAMS, WASHINGTON, DC. EPA
540/09-90-077. NTIS PB90-143025.
ETHYLNITROSOUREA 000759-73-9
010426 US EPA. 1988. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK GROUP.
FOLPET 000133-07-3
010120 CHEVRON CHEMICAL COMPANY. 1982. CHEVRON STUDY: LIFETIME ONCOGENICITY FEEDING STUDY OF PHOLTON TECHNICAL (SX-946, FOLPET)
IN CD-1 (ICR DERIVED) MICE. AUGUST 24. SOCIAL STUDY NO. 1331.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR FOLPET. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
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FORMALDEHYDE 000050-00-0
010121 KERNS ET AL., 1983. CARCINOGENICITY OF FORMALDEHYDE IN RATS AND MICE AFTER LONG-TERM INHALATION EXPOSURE. CANCER RES.
43(9):4382-4392.
US EPA. 1988. CRAVE VERIFICATION MEETING NOTES OF 02/03/88. CARCINOGEN RISK ASSESSMENT VERIFICATION ENDEAVOR (CRAVE) WORK
GROUP, OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT, WASHINGTON, DC.
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005126 NCI (NATIONAL CANCER INSTITUE). 1978. BIOASSAY OF TETRACHLOROVINPHOS FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGEN TECH REP
SER NO. 33 NTIS PB278650.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR STIROPHOS. PREPARED BY THE OFFICE OF HEALTH
AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERAIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE
AND EMERGENCY RESPONSE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY January 1992
TOLUENE-2,4-DIAMINE 000095-80-7
010160 NCI (NATIONAL CANCER INSTITUTE). 1979. BIOASSAY OF 2.4- OIAMINOTOLUENE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGEN TECH
REP SER NO. 162.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR 2,4- TOLUENEDIAMINE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
TOLUIDINE, P- 000106-49-0
010162 WEISBURGER EK, AB RUSSFIELD AND F HOMBURGER, ET AL. 1978. TESTING OF TWENTY-ONE ENVIRONMENTAL AROMATIC AMINES OR
DERIVATIVES FOR LONG-TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL. 2(2): 325-356.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TOLUIDINES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
TOXAPHENE 008001-35-2
005134 LITTON BIONETICS, INC. 1978. CARCINOGENIC EVALUATION IN MICE: TOXAPHENE. PREPARED BY LITTON BIONETICS, INC., KENSINGTON, MD
FOR HERCULES, INC, WILMINGTON, DE. LBI PROJECT NO. 20602.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR TOXAPHENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
DC.
US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR TOXAPHENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER REGULATIONS AND STANDARDS,
WASHINGTON, DC.
TRICHLOROANILINE,2,4,6- 000634-93-5
001111 WEISBURGER, EL, AB RUSSFIELD, R HOMBURGER, ET AL. 1978. TESTING OF 21 ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR
LONG-TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL 2: 325- 356.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROANILINES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
TRICHLOROANILINE HYDROCHLORIDE, 2,4,6- 033663-50-2
005142 WEISBURGER, EL, AB RUSSFIELD, R HOMBURGER, ET AL. 1978. TESTING OF 21 ENVIRONMENTAL AROMATIC AMINES OR DERIVATIVES FOR
LONG-TERM TOXICITY OR CARCINOGENICITY. J ENVIRON PATHOL TOXICOL 2: 325- 356.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR TRICHLOROANILINES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY January 1992
TRICHLOROETHANE, 1,1,2- 000079-00-5
005144 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF 1,1,2- TRICHLOROETHANE FOR POSSIBLE CARCINOGENICITY. NCI CARCINOGENESIS
TECH REP SER NO 74, OHEW NO NIH 78-1324.
US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLORINATED ETHANES. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER REGULATIONS
AND STANDARDS, WASHINGTON, DC.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 1,1,2-TRICHLOROETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
WASHINGTON, DC.
TRICHLOROETHYLENE 000079-01-6
009996 CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300; FTS 684-7300.
TRICHLOROPHENOL, 2,4,6- 000088-06-2
010428 NCI (NATIONAL CANCER INSTITUTE). 1979. BIOASSAY OF 2,4,6- TRICHLOROPHENOL FOR POSSIBLE CARCINOGENICITY. NCI
CARCINOGENESIS TECH REP SER NO 155, DHEW NO NIH 79-1711.
US EPA. 1980. AMBIENT WATER QUALITY CRITERIA DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER REGULATIONS
AND STANDARDS, WASHINGTON, DC.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR 2,4,6-TRICHLOROPHENOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL
RESPONSE, WASHINGTON, DC.
US EPA. 1987. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLORINATED PHENOLS. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
TRIFLURALIN 001582-09-8
010163 EMMERSON JL, EC PIERCE, JP MCGRATH, ET AL. 1980. THE CHRONIC TOXICITY OF COMPOUND 36352 (TRIFLURALIN) GIVEN AS A COMPOUND
OF THE DIET TO FISCHER 344 RATS FOR TWO YEARS. STUDIES R-87 AND R-97 (UNPUBLISHED STUDY RECEIVED SEPTEMBER 18, 1980 UNDER
1471-35, SUBMITTED BY ELANCO PRODUCTS CO., DIVISION OF ELI LILLY AND CO., INDIANAPOLIS, IN).
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIFLURALIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
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REFERENCES FOR HEAST TABLE 3: CARCIN06ENICITY January 1992
TRIMETHYL PHOSPHATE 000512-56-1
010164 NCI (NATIONAL CANCER INSTITUTE). 1978. BIOASSAY OF TR1HETHYLPHOSPHATE FOR POSSIBLE CARCINOGEN!CITY. NCI CARCINOGEN TECH REP
SER NO. 81.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIMETHYL PHOSPHATE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
TRINITROTOLUENE,2,4,6 (TNT) 000118-96-7
009990 US DOD (DEPARTMENT OF DEFENSE). 1984. AD-A168637. DEFENSE TECHNICAL CENTER. CAMERON STATION, ALEXANDRIA, VA.
US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 2,4,6-TRINITROTOLUENE. PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND
EMERGENCY RESPONSE, WASHINGTON, DC.
VINYL CHLORIDE 000075-01-4
010368 FERON, VJ, CFM HENDRIKSEN, AJ SPEEK, ET AL. 1981. LIFESPAN ORAL TOXICITY STUDY OF VINYL CHLORIDE IN RATS. FOOD COSMET
TOXICOL 19(3):317-333.
US EPA. 1984. HEALTH EFFECTS ASSESSMENT FOR VINYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON,
DC.
US EPA. 1985. DRINKING WATER CRITERIA DOCUMENT FOR VINYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF DRINKING WATER, WASHINGTON, DC.
010367 MALTONI, C, G LEFEMINE, A CILIBERTI ET AL. 1980. VINYL CHLORIDE CARCINOGENICITY BIOASSAYS (BT PROJECT) AS AN EXPERIMENTAL
MODEL FOR RISK IDENTIFICATION AND ASSESSMENT IN ENVIRONMENTAL AND OCCUPATIONAL CARCINOGENESIS. EPIDEMIOL ANIM EPIDEMIOL
HUM: CAS CHLORURE VINYLE MONOMERE, (REUN CLUB CANCEROG CHIM), 20TH, MEETING DATE 1979, P. 11-112. PUBL ESSENT, PARIS,
FRANCE.
MALTONI, C, G LEFEMINE, A CILIBERTI ET AL. 1981. CARCINOGENICITY BIOASSAYS OF VINYL CHLORIDE MONOMER: A MODEL OF RISK
ASSESSMENT ON AN EXPERIMENTAL BASIS. ENVIRON HEALTH PERSPECT 41: 329.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CHLOROETHENE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
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APPENDIX A: TECHNICAL INFORMATION
I. DATA SOURCES AND SELECTION CRITERIA USED IN HEAST
II. DOSE CONVERSIONS ON HEAST
III. CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE
REGISTRY NUMBER CROSS REFERENCE
IV. EFFECT LEVEL DEFINITIONS
V. NATIONAL AMBIENT AIR QUALITY STANDARDS (NAAQS)
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APPENDIX A-I
I. DATA SOURCES AND SELECTION CRITERIA USED IN HEAST
A. Description of Sources and Documents Cited in HEAST
1. The Integrated Risk Information System (IRIS):
IRIS is an on-line database developed by the EPA
for compilation of risk assessment and regulatory
information on chemicals and physical agents. There
are 491 individual chemicals or class listings as of
November 1991. IRIS is the primary communications
mechanism for distribution of health hazard assessment
information derived by the various intra-Agency Work
Groups. The primary intent of IRIS is to provide
guidance to EPA personnel in making risk management
decisions. An IRIS chemical file contains a Work Group
verified summary of the available information on hazard
and dose-response assessment for noncarcinogenic and/or
carcinogenic effects for that chemical and is not an
extensive toxicologic data base. Risk assessment
values placed on IRIS are considered Agency consensus
and take precedence over differing risk assessment
values from other EPA sources. Each file includes
referenced citations and EPA contacts for obtaining
further information on any specific chemical or agent.
The IRIS database was made available to State and local
governments, as well as to the public, in April 1988.
*Questions concerning IRIS: Call IRIS USER SUPPORT at
(513) 569-7254 or FTS 684-7254
2. EPA Work Groups:
Risk assessment values for chemicals currently
being considered by EPA Work Groups, but not yet on
IRIS, are included in HEAST. The EPA Reference
Dose/Reference Concentration (RfD/RfC) Work Group and
the Carcinogen Risk Assessment Verification Endeavor
(CRAVE) Work Group validates Agency systemic toxicity
and carcinogen risk assessments, respectively. These
Work Groups are also responsible for resolving any
conflicts regarding toxicity values developed by
various Program Offices. Work Group members represent
many different EPA offices and are scientists
experienced in issues related to both the qualitative
and quantitative risk assessment of carcinogenic and
toxic agents. Values verified by these Work Groups
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have undergone extensive peer review and represent an
Agency consensus. Verified risk assessment values are
entered into the IRIS data base monthly.
*Questions concerning RfD/RfC Work Group: Call Mike
Dourson (ECAp-Cincinnati) at (513) 569-7533 (FTS 684-
7533) or Annie Jarabek (ECAO-Research Triangle Park) at
(919) 541-4847 (FTS 629-4847)
*Questions concerning CRAVE Work Group: Call Rita
Schoeny (ECAO-Cincinnati) at (513) 569-7544 (FTS 684-
7544)
3. Office of Research and Development
(ORD)/Office of Health and Environmental
Assessment (OHEA) OSWER-OAQPS (Office of Solid
Waste and Emergency Response-Office of Air Quality
Planning and Standards) Documents:
A listing of most ORD/OHEA OSWER-OAQPS documents
can be found in the Chemical Assessments and Related
Activities (CARA) list (available through NTIS) and/or
in the CERI (Center for Environmental Research
Information) Office of Research and Development
publications list. The CARA is produced by the Office
of Health and Environmental Assessment (OHEA). All
OSWER-OAQPS documents are subject to a minimum of
internal EPA peer review or a maximum of EPA/Peer
Review Workshop/Science Advisory Board and public
comments prior to finalization.
*Information on the availability of OSWER-OAQPS
documents can be obtained from the following sources:
All Documents;
Technical Information Staff
Office of Health and Environmental Assessment (RD-
689)
U.S. Environmental Protection .Agency
401 M Street, S.W.
Washington, D.C. 20460
FTS or (202) 260-7345
Published Documents;
Center for Environmental Research Information
(CERI)
Office of Research and Development
U.S. Environmental Protection Agency
26 W. Martin Luther King Drive
A-2
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Cincinnati, OH 45268
FTS 684-7562 or (513) 569-7562
Documents Available Through RCRA/Superfund:
Hotline Number 1-800-424-9346
Documents Available from NTIS:
National Technical Information Service (NTIS)
5285 Port Royal Road
Springfield, VA 22161
(703) 487-4650
Health Effects Assessments (HEAs); This document
series was prepared by the Environmental Criteria and
Assessment Office (ECAO-Cincinnati) for the Office of
Emergency and Remedial Response (Superfund). HEAs are
intended for use "by the OERR in evaluating risk for its
preliminary assessment process at uncontrolled sites,
and for appraising clean-up alternatives in its
remedial investigation/feasibility studies. HEAs are
brief, quantitatively oriented, preliminary assessment
of relevant health effects data. HEAs are subject to
internal EPA review by staff within the Office of
Health and Environmental Assessment. Final drafts of
HEAs become part of the RCRA and Superfund dockets and
are available through NTIS. This series has recently
been incorporated into the following HEED series.
Health and Environmental Effects Documents (HEEDs):
This document series is prepared by the Environmental
Criteria and Assessment Office (ECAO-Cincinnati) for
the Office of Solid Waste and Emergency Response
(OSWER). HEEDs are intended to support listings under
the Resource Conservation and Recovery Act (RCRA) as
well as to provide health-related limits and goals for
emergency and remedial actions under the Comprehensive
Environmental Response, Compensation and Liability Act
(CERCLA). Within a HEED, both published literature and
information within Agency Program Offices are evaluated
as they pertain to potential human health, aquatic life
and environmental effects of hazardous waste
constituents. Quantitative estimates, including
reference doses for chronic and subchronic duration for
both inhalation and oral exposures, carcinogenic
potency factors, unit risk estimates for air and
drinking water, and reportable quantities (RQs) based
on chronic toxicity and carcinogenicity are determined
when sufficient data are available. HEEDs are subject
to internal EPA review by staff within the Office of
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Health and Environmental Assessment and the Office of
Pesticides and Toxic Substances. Final drafts of HEEDs
become part of the RCRA and Superfund public dockets
and are available through NTIS.
Health and Environmental Effects Profiles (HEEPs);
This document series was prepared by the Environmental
Criteria and Assessment Office (ECAO-Cincinnati) for
the Office of Solid Waste and Emergency Response
(OSWER). HEEPs have been superseded by HEEDs since
mid-FY87. HEEPs are intended to support listings of
hazardous constituents of a wide range of waste streams
under Section 3001 of the Resource Conservation and
Recovery Act (RCRA), as well as to provide health-
related limits for emergency actions under Section 010
of the Comprehensive Environmental Response,
Compensation and Liability Act (CERCLA). HEEPs are
summaries of the literature concerning health hazards
associated with environmental exposures to chemicals or
compounds and are very similar to HEEDs as described
above. HEEPs were subject to internal EPA review by
staff within the Office of Health and Environmental
Assessment. HEEPS are part of the RCRA and CERCLA
public dockets. Final drafts are available through
NTIS.
Air Quality Criteria Documents (AQCDs): This document
series is prepared by the Environmental Criteria and
Assessment Office (ECAO-Research Triangle Park) for the
Office of Air and Radiation (OAR). AQCDs are intended
to support National Ambient Air Quality Standards
(NAAQS) set under Sections 108-110 of the Clean Air
Act. These documents are evaluations of the available
scientific literature on the potential health effects
of air pollutants. AQCDs are subject to internal EPA
review by staff within the Office of Health and
Environmental Assessment and the Office of Air and
Radiation. Further review is conducted by the Science
Advisory Board/Clean Air Scientific Advisory Committee,
and then, these documents are subject to peer review
workshops and public comments. The AQCDs are mandated
by the Clean Air Act and are revised at 5-year
intervals. AQCDs become part of the OAR public docket
and final drafts are available through NTIS.
Health Assessment Documents (HADs): This document
series is prepared by the Environmental Criteria and
Assessment Office (ECAO-Research Triangle Park and
ECAO-Cincinnati) for the Office of Air and Radiation
(OAR). HADs are intended for use by the Office of Air
Quality Planning and Standards (OAQPS) to determine
possible listing of hazardous air pollutants (HAP)
A-4
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under sections 111 and 112 of the Clean Air Act. These
documents are evaluations of the available scientific
literature on the potential health effects of air
pollutants and serve as the scientific data base for
establishing relationships between exposure
concentrations and potential health risks. HADs are
subject to internal EPA review by staff within the
Office of Health and Environmental Assessment and the
Office of Air and Radiation. Further review is
conducted by the Science Advisory Board/Clean Air
Scientific Advisory Committee, and then, these
documents are subject to peer review workshops and
public comments. HADs become part of the OAR public
docket and final drafts are available through NTIS.
4. Miscellaneous Documents:
Drinking Water Criteria Documents (DWCDs): The
Environmental Criteria and Assessment Office (ECAO-Cin)
prepares a portion of this document series for the
Office of Water (OW). DWCDs are intended to assist the
OW in deriving criteria standards for chemicals in
drinking water, as required under Section 412(b)(3)(A)
of the Safe Drinking Water Act, as amended in 1986.
The DWCDs are comprehensive evaluations of potential
health effects, including mechanisms of toxicity, with
specific emphasis on data providing dose-response
information. DWCDs contain Health Advisories (HAs) for
1-day, 10-day and longer-term exposures and drinking
water equivalent levels for lifetime exposures. DWCDs
are subject to internal EPA review by staff within the
Office of Health and Environmental Assessment and the
Office of Water. Selected documents are reviewed by
the Science Advisory Board and are subject to peer
review workshops and public comments. DWCDs become
part of the Safe Drinking Water (SOW) public docket and
final drafts are available through NTIS.
B. Selection Criteria and Sources of HEAST Values
Chemicals with derived noncarcinogenic and/or
carcinogen risk assessment values that have had some
level of peer review (i.e., those in peer reviewed EPA
documents or under review by EPA Work Groups) are
included in HEAST; this does not include many interim
values (values not found in final EPA documents or not
being considered by Work Groups) derived for various
purposes within Superfund and other Program Offices.
In updating the HEAST, the first source that is checked
is the Integrated Risk Information System (IRIS) for
revised or newly added risk assessment values.
A-5
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Secondly, the status of chemicals under discussion by
the RfD/RfC and CRAVE Work Groups is reviewed. The
Office of Health and Environmental Assessment's
Chemical Assessments and Related Activities (CARA) list
is also reviewed for new Office of Water, Office of Air
Quality Planning and Standards, and Office of Solid
Waste and Emergency Response risk assessment documents
(HEEDS, KEEPS, HEAs, HADs, AQCDs, DWCDs).
The HEAST also contains chemicals commonly found
at RCRA (Resource Conservation and Recovery Act) sites
as identified by the Office of Solid Waste's Technical
Assessment Branch. Questions about RCRA chemicals may
be addressed by calling the Health Assessment Section
(Office of Solid Waste) at (202) 260-4761 (FTS 260-
4761). Finally, the Office of Radiation Programs
provides data on radionuclides for Tables 4A and 4B of
the HEAST. Radionuclides included are those thought to
be most commonly encountered at Superfund sites.
Questions concerning radionuclide carcinogenicity
should first be addressed by contacting the appropriate
Regional Radiation Program Manager. A listing of these
managers and several contacts in the Office of
Radiation Programs can be found in the User's Guide -
Radionuclide Carcinogenicity on pages 46-48.
A-6
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APPENDIX A-II
II. DOSE CONVERSIONS ON HEAST
In January 1991, the decision was made to replace inhalation
Reference Doses (RfDi) for noncancer toxicity and inhalation slope
factors for carcinogenicity, previously available on the IRIS data
base, with Reference Concentrations (RfC) and inhalation unit
risks, respectively. RfCs and unit risks are expressed in terms of
concentration in air (mg/m3) , not in terms of "dose" (mg/kg-day)
like the RfDs and the oral and inhalation slope factors. This
presents a problem for the Superfund program, since the current
Hazard Ranking System (HRS) and the Risk Assessment Guidance for
Superfund (RAGS): Human Health Evaluation Manual, Parts A and B
were developed using chronic daily intakes and health criteria
expressed in units of mg/kg-day.
The decision to replace inhalation slope factors and RfDi
values expressed in mg/kg-day with unit risk and RfC values
expressed in mg/m3 was based on two major factors: 1) the
workgroups felt that it was technically more accurate to base
toxicity values directly on measured air concentrations instead of
making the metabolic, pharmacokinetic and/or surface area
adjustments required to estimate an "internal dose"; and 2) there
are compounds that elicit route-of-entry effects (e.g., sensitizers
and irritants) where the toxic effect is to the respiratory system
or exchange boundary where a measure of "internal dose" might
inappropriately imply effects to other organ systems or effects
from other exposure routes.
Superfund recognizes the importance of these issues and is
actively working with EPA's Office of Research and Development to
evaluate the impact of these changes on its program regulations and
guidance. In the short term, however, modification of program
regulations and guidance is not a viable option. Therefore, the
chairs of the RfD/RfC and CRAVE Work Groups were consulted
regarding Superfund's need to make the conversion from a
concentration in air to dose. There was agreement that, in many
cases, converting the air concentration data to a dose (in
mg/kg-day) may not add significant uncertainty to the Superfund
risk assessment process, and therefore may be a reasonable use of
the data given appropriate circumstances and Superfund program
objectives. These Work Groups will continue to work with the
Superfund program to identify specific instances where it is not
appropriate to make the conversion from unit risk/RfC to inhalation
slope factor/RfD due to the large uncertainty introduced by the
assumptions used in the conversion.
Generally, the Superfund Health Risk Technical Support Center
will be responsible for making all appropriate conversions and the
values will be identified with appropriate highlights or footnotes
A-7
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in the Health Effects Assessment Summary Tables (HEAST).
Therefore, HEAST users are strongly advised against making such
conversions themselves. However, it is a critical responsibility
of the risk assessor to consult the original reports cited in the
HEAST and to appropriately characterize or caveat the resulting
risk estimates derived from these values so that managers are fully
informed of their origin and related uncertainties.
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APPENDIX A-III
III. CHEMICAL NAME AND
CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER
CROSS REFERENCE
This section lists chemicals and their respective Chemical
Abstracts Service Registry Number (CASRN) for cross referencing on
the HEAST. Table A-III-1 is listed in numerical order by the CASRN
and Table A-III-2 is listed in alphabetical order by the chemical
name.
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TABLE A-III-1
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY CASRN)
NAME
I
H
O
2,3-
CASRN
000050-32-8 BENZO(A)PYRENE
000050-00-0 FORMALDEHYDE
000050-29-3 DDT
000051-28-5 DINITROPHENOL,
000051-28-5 DINITROPHENOL, 2,4-
000053-70-3 DIBENZ(A,H)ANTHRACENE
000055-18-5 NITROSODIETHYLAMINE, N-
000056-55-3 BENZ(A)ANTHRACENE
000056-49-5 METHYLCHLOLANTHRACENE, 3-
000056-38-2 PARATHION
000056-53-1 DIETHYLSTILBESTEROL
000056-23-5 CARBON TETRACHLORIDE
000057-55-6 PROPYLENE GLYCOL
000057-74-9 CHLORDANE
000057-12-5 CYANIDE (CN-)
000057-14-7 DIMETHYLHYDRAZINE, 1,1-
000057-24-9 STRYCHNINE
000058-89-9 HEXACHLOROCYCLOHEXANE, GAMMA-
000058-90-2 TETRACHLOROPHENOL, 2,3,4,6-
000059-50-7 CHLORO-M-CRESOL, P-
000059-87-0 NITROFURAZONE
000060-51-5 DIMETHOATE
000060-29-7 ETHYL ETHER
000060-34-4 METHYL HYDRAZINE
000060-57-1 DIELDRIN
000062-38-4 PHENYLMERCURIC ACETATE
000062-74-8 SODIUM FLUOROACETATE
000062-75-9 NITROSODIMETHYLAMINE, N-
000062-53-3 ANILINE
000063-25-2 CARBARYL
000064-18-6 FORMIC ACID
000065-85-0 BENZOIC ACID
000067-64-1 ACETONE
000067-56-1 METHANOL
000067-66-3 CHLOROFORM
000067-45-8 FURAZOLIDONE
000067-20-9 NITROFURANTOIN
000067-72-1 HEXACHLOROETHANE
000068-12-2 DIMETHYLFORMAMIDE, N,N-
000070-30-4 HEXACHLOROPHENE
000071-55-6 TRICHLOROETHANE, 1,1,1-
000071-43-2 BENZENE
000071-36-3 BUTANOL, 1-
CASRN KANE CASRN
000071-23-8 PROPYL ALCOHOL, N- 000078-93-3
000072-20-8 ENDRIN 000079-00-5
000072-54-8 ODD 000079-06-1
000072-43-5 METHOXYCHLOR 000079-20-9
000072-55-9 DDE 000079-10-7
000074-95-3 METHYLENE BROMIDE 000079-46-9
000074-11-3 CHLOROBENZOIC ACID, P- 000079-34-5
000074-87-3 CHLOROMETHANE 000079-22-1
000074-83-9 BROMOMETHANE 000079-11-8
000075-44-5 PHOSGENE 000079-01-6
000075-01-4 VINYL CHLORIDE 000080-62-6
000075-25-2 BROMOFORM 000080-05-7
000075-52-5 NITROMETHANE 000081-81-2
000075-71-8 DICHLORODIFLUOROMETHANE 000082-68-8
000075-34-3 DICHLOROETHANE, 1,1- 000083-32-9
000075-35-4 OICHLOROETHYLENE, 1,1- 000084-66-2
000075-60-5 CACODYLIC ACID 000084-74-2
000075-27-4 BROMODICHLOROMETHANE 000085-01-8
000075-87-6 CHLORAL 000085-44-9
000075-56-9 PROPYLENE OXIDE 000085-68-7
000075-29-6 CHLOROPROPANE, 2- 000086-73-7
000075-99-0 DALAPON 000086-30-6
000075-15-0 CARBON DISULFIDE 000086-74-8
000075-69-4 TRICHLOROFLUOROMETHANE 000087-68-3
000075-05-8 ACETONITRILE 000087-84-3
000075-86-5 ACETONE CYANOHYDRIN
000075-21-8 ETHYLENE OXIDE 000087-84-3
000075-09-2 METHYLENE CHLORIDE
000075-07-0 ACETALDEHYDE 000087-82-1
000075-00-3 ETHYL CHLORIDE 000087-65-0
000076-44-8 HEPTACHLOR 000087-86-5
000076-13-1 TRICHLORO-1,2,2- TRIFLUOROETHANE, 000088-99-3
1,1,2- 000088-74-4
000077-78-1 DIMETHYLSULFATE 000088-06-2
000077-47-4 HEXACHLOROCYCLOPENTADIENE 000088-72-2
000077-73-6 DICYCLOPENTADIENE 000088-85-7
000078-48-8 MERPHOS OXIDE 000088-73-3
000078-59-1 ISOPHORONE 000090-43-7
000078-97-7 LACTONITRILE 000091-66-7
000078-99-9 DICHLOROPROPANE,1,1- 000091-22-5
000078-86-4 CHLOROBUTANE, 2- 000091-20-3
000078-87-5 DICHLOROPROPANE, 1,2- 000091-94-1
000078-83-1 ISOBUTYL ALCOHOL 000092-87-5
MAKE
METHYL ETHYL KETONE
TRICHLOROETHANE, 1,1,2-
ACRYLAMIDE
METHYL ACETATE
ACRYLIC ACID
NITROPROPANE, 2-
TETRACHLOROETHANE, 1,1,2,2-
METHYL CHLOROCARBONATE
CHLOROACETIC ACID
TRICHLOROETHYLENE
METHYL METHACRYLATE
BISPHENOL A
WARFARIN
PENTACHLORONITROBENZENE
ACENAPHTHENE
'DIETHYL PHTHALATE
DIBUTYL PHTHALATE
PHENANTHRENE
PHTHALIC ANHYDRIDE
BUTYL BENZYL PHTHLATE, N-
FLUORENE
NITROSODIPHENYLAMINE, N-
CARBAZOLE
HEXACHLOROBUTADIENE
CYCLOHEXANE,
1,2,3,4,5-PENTABROMO-6-CHLORO-
PENTABROMO-6-CHLORO-CYCLOHEXANE,
1,2.3,4,5-
HEXABROMOBENZENE
DICHLOROPHENOL, 2.6-
PENTACHLOROPHENOL
PHTHALIC ACID, 0-
NITROANILINE, 0-
TRICHLOROPHENOL, 2,4,6-
NITROTOLUENE, 0-
DINOSEB
CHLORONITROBENZENE, 0-
PHENYLPHENOL, 2-
DIETHYLANILINE.N.N-
QUINCLINE
NAPHTHALENE
DICHLOROBENZIDINE, 3,3'-
BENZIDINE
-------
CASRN
TABLE A-III-1
NAME
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY CASRN) (Continued)
CASRN
NAME
CASRN
NAME
000092-52-4 BIPHENYL, 1,1'-
000093-65-2 METHYL-4-CHLOROPHENOXY)PROPIONIC
ACID, 2-(2-
000093-76-5 TRICHLOROPHENOXYACETIC ACID, 2,4,5-
000093-72-1 TRICHLOROPHENOXY) PROPIOMIC ACID,
2(2,4,5-
000093-71-0 ALLIDOCHLOR
000094-82-6 DICHLOROPHENOXY5BUTYRIC ACID, 4-(2,4-
000094-75-7 DICHLOROPHENOXYACETIC ACID, 2,4-
000094-81-5 METHYL-4-CHLOROPHENOXY)BUTYRIC ACID, 4-
000094-74-6 .METHYL-4-CHLOROPHENOXYACETIC ACID, 2-
000095-70-5 TOLUENE-2.5-DIAMINE
000095-95-4 TRICHLOROPHENOL, 2,4,5-
000095-48-7 CRESOL, 0-
000095-69-2 CHLORO-2-METHYLAN1LINE, 4-
000095-87-4 DIMETHYLPHENOL, 2,5-
000095-77-2 DICHLOROPHENOL, 3,4-
000095-55-6 AMINOPHENOL, 0-
000095-53-4 METHYLANILINE, 2-
000095-51-2 CHLOROANILINE, 2-
000095-54-5 PHENYLENEDIAMINE, 0-
000095-50-1 DICHLOROBENZENE, 1,2-
000095-94-3 TETRACHLOROBENZENE, 1,2,4,5-
000095-49-8 CHLOROTOLUENE, 0-
000095-68-1 DIMETHYLANILINE, 2,4-
000095-57-8 CHLOROPHENOL, 2-
000095-65-8 DIMETHYLPHENOL, 3,4-
000095-47-6 XYLENE, 0-
000096-48-0 BUTYROLACTONE, GAMMA-
000096-33-3 METHYL ACRYLATE
000096-19-5 TRICHLOROPROPENE, 1,2,3-
000096-12-8 DIBROMO-3-CHLOROPROPANE, 1,2-
000096-18-4 TRICHLOROPROPANE, 1,2,3-
000096-45-7 ETHYLENE THIOUREA
000097-63-2 ETHYL METHACRYLATE
000098-82-8 CUMENE
000098-56-6 CHLOROBENZOTRIFLUORIDE, 4-
000098-86-2 ACETOPHENONE
000098-95-3 NITROBENZENE
000098-01-1 FURFURAL
000098-87-3 BENZAL CHLORIDE
000098-83-9 METHYL STYRENE, ALPHA-
000098-07-7 BENZOTRICHLORIDE
000099-55-8 METHYL-5-NITROANILINE, 2-
000099-99-0 NITROTOLUENE, P-
000099-59-2 METHOXY-5-NITROANILINE, 2-
000099-35-4 TRINITROBENZENE, 1,3,5-
000099-08-1 NITROTOLUENE, M-
000099-65-0 DINITROBENZENE, 1,3-
000099-09-2 NITROANILINE, M-
000100-52-7 BENZALDEHYDE
000100-41-4 ETHYLBENZENE
000100-44-7 BENZYL CHLORIDE
000100-51-6 BENZYL ALCOHOL
000100-42-5 STYRENE
000100-54-9 NICOTINONITIRLE
000100-40-3 VINYL-1-CYCLOHEXENE
000100-21-0 TEREPHTHALIC ACID
000100-01-6 NITROANILINE, P-
000100-21-0 PHTHALIC ACID, P-
000100-25-4 DINITROBENZENE, 1,4-
000101-61-1 METHYLENE-BIS(N,M-DIMETHYL) ANILINE,
4,4-
000101-14-4 METHYLENE-BIS-(2-CHLOROANILINE),
4,4'-
000101-55-3 BROMOPHENYLPHENYL ETHER, 4-
000101-77-9 METHYLENEBISBENZENAMINE, 4,4'-
000101-68-8 METHYLENEDIPHENYL ISOCYANATE, 4,4'-
000103-33-3 AZOBENZENE
000103-69-5 ETHYLANILINE, N-
000105-67-9 DIMETHYLPHENOL, 2,4-
000105-60-2 CAPROLACTAM
000106-43-4 CHLOROTOLUENE, P-
000106-13-8 ETHOXYETHANOL DODECANOATE.2-
000106-89-8 EPICHLOROHYDRIN
000106-47-8 CHLOROANILINE, 4-
000106-99-0 BUTADIENE, 1,3-
000106-42-3 XYLENE, P-
000106-46-7 DICHLOROBENZENE, 1,4-
000106-49-0 TOLUIDINE, P-
000106-93-4 DIBROMOETHANE, 1,2-
000106-44-5 CRESOL, P-
000106-48-0 CHLOROPHENOL, 4-
000106-37-6 DIBROMOBENZENE, 1,4-
000106-47-8 CHLORANILINE, P-
000106-74-1 ETHOXYETHYL ACRYLATE,2-
000106-50-3 PHENYLENEDIAMINE, P-
000107-15-3 ETHYLENE DIAMINE
000107-18-6 ALLYL ALCOHOL
000107-21-1 ETHYLENE GLYCOL
000107-02-8 ACROLEIN
000107-98-2 PROPYLENE GLYCOL MONOMETHYL ETHER
000107-30-2 CHLOROMETHYL METHYL ETHER
000107-13-1 ACRYLONITRILE
000107-05-1 ALLYL CHLORIDE
000107-12-0 PROPIONITRILE
000107-06-2 DICHLOROETHANE, 1,2-
000107-20-0 CHLOROACETALDEHYDE
000107-16-4 FORMALDEHYE CYANOHYDRIN
000108-90-7 CHLOROBENZENE
000108-10-1 METHYL ISOBUTYL KETONE
000108-88-3 TOLUENE
000108-94-1 CYCLOHEXANONE
000108-05-4 VINYL ACETATE
000108-31-6 MALEIC ANHYDRIDE
000108-45-2 PHENYLENEDIAMINE, M-
000108-38-3 XYLENE, M-
000108-39-4 CRESOL, M-
000108-43-0 CHLOROPHENOL, 3-
000108-44-1 TOLUIDINE, M
000108-91-8 CYCLOHEXYLAMINE
000108-42-9 CHLOROANILINE, 3-
000108-41-8 CHLOROTOLUENE, M-
000108-95-2 PHENOL
000109-86-4 METHOXYETHANOL, 2-
000109-66-0 PENTANE, N-
000109-78-4 ETHYLENE CYANOHYDRIN
000109-69-3 CHLOROBUTANE, 1-
000109-77-3 MALONONITRILE
000110-54-3 HEXANE, N
000110-49-6 METHOXYETHANOL ACETATE, 2-
000110-61-2 SUCCINONITRILE
000110-86-1 PYRIDINE
000110-00-9 FURAN
000110-80-5 ETHOXYETHANOL, 2-
000111-15-9 ETHOXYETHANOL ACETATE, 2-
-------
CASRN
TABLE A-III-1
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY CASRN) (Continued)
NAME
CASRN
NAME
CASRN
NAME
I
H
000111-44-4 BIS(2-CHLOROETHYL) ETHER
000111-69-3 ADIPONITRILE
000111-90-0 DIETHYLENE GLYCOL MONOETHYL ETHER
000111-76-2 ETHYLENE GLYCOL MONOBUTYL ETHER
000112-34-5 DIETHYLENE GLYCOL MONOBUTYL ETHER
000115-29-7 ENDOSULFAN
000116-06-3 ALDICARB
000117-84-0 DI-N-OCTYL PHTHALATE
000117-81-7 BIS(2-ETHYLHEXYL)PHTHALATE
000118-75-2 CHLORANIL
000118-96-7 TRINITROTOLUENE, 2,4,6-
000118-74-1 HEXACHLOROBENZENE
000119-90-4 DIMETHOXYBENZIOINE, 3,3'-
000119-93-7 DIMETHYLBENZIDINE, 3,3'-
000120-83-2 DICHLOROPHENOL, 2,4-
000120-61-6 DIMETHYLTEREPHTHALATE
000120-36-5 OICHLOROPROP
000120-12-7 ANTHRACENE
000120-82-1 TRICHLOROBENZENE, 1,2,4-
000121-14-2 DINITROTOLUENE, 2,4-
000121-73-3 CHLORONITROBENZENE, P-
000121-73-3 CHLORONITROBENZENE, M-
000121-75-5 MALATHION
000121-69-7 DIMETHYLANILINE, N,N-
000121-91-5 PHTHALIC ACID, M-
000121-82-4 RDX (CYCLONITE)
000122-66-7 DIPHENYLHYDRAZINE, 1,2-
000122-39-4 DIPHENYLAMINE,N,N-
000122-34-9 SIMAZINE
000123-31-9 HYDROQUINONE
000123-91-1 DIOXANE, 1,4-
000123-33-1 MALEIC HYDRAZIDE
000123-30-8 AMINOPHENOL, P-
000123-63-7 PARALDEHYDE
000123-73-9 CROTONALDEHYDE
000124-48-1 OIBROMOCHLOROMETHANE
000124-48-5 CHLORODIBROMOMETHANE
000124-09-4 HEXAMETHYLENE DIAMINE
000126-99-8 CHLORO-1.3-BUTADIENE, 2-
000126-98-7 METHACRYLONITRILE
000127-18-4 TETRACHLOROETHYLENE, 1,1,2,2-
000129-00-0 PYRENE
000130-15-4 NAPHTHOQUINONE 000479-45-8
000131-11-3 DIMETHYL PHTHALATE 000496-72-0
000132-64-9 DIBENZOFURAN 000504-24-5
000133-06-2 CAPTAN 000506-64-9
000133-07-3 FOLPET 000506-77-4
000137-26-8 THIRAM 000506-61-6
000139-40-2 PROPAZINE 000506-68-3
000140-88-5 ETHYL ACRYLATE 000507-20-0
000140-57-8 ARAMITE 000510-15-6
000141-78-6 ETHYL ACETATE 000512-56-1
000142-28-9 DICHLOROPROPANE, 1,3- 000526-75-0
000142-82-5 HEPTANE, N- 000528-29-0
000143-33-9 SODIUM CYANIDE 000531-82-8
000145-73-3 ENDOTHALL 000534-52-1
000148-18-5 SODIUM OIETHYLDITHIOCARBAMATE 000541-73-1
000150-50-5 MERPHOS 000542-92-7
000151-50-8 POTASSIUM CYANIDE 000542-62-1
000152-16-9 OCTAMETHYLPYROPHOSPHORAMIDE 000542-75-6
000156-60-5 DICHLOROETHYLENE, 1,2-T- 000542-88-1
000156-59-2 DICHLOROETHYLENE, CIS-1,2,- 000544-92-3
000191-24-2 BENZO(G,H,I)PERYLENE 000557-21-1
000193-39-5 INDENO(1,2,3-CD)PYRENE 000563-68-8
000205-99-2 BENZO(B)FLUORANTHENE 000573-56-8
000206-44-0 FLUORANTHENE 000576-26-1
000207-08-9 BENZOCK]FLUORANTHENE 000576-24-9
000208-96-8 ACENAPHTHYLENE 000583-78-8
000218-01-9 CHRYSENE 000586-11-8
000298-00-0 METHYL PARATHION 000591-27-5
000298-04-4 DISULFOTON 000591-35-5
000298-02-2 PHORATE 000591-78-6
000299-84-3 RONNEL 000592-01-8
000302-01-2 HYDRAZINE 000598-94-7
000304-61-0 ANTIMONY POTASSIUM TARTRATE 000598-77-6
000309-00-2 ALDRIN 000602-01-7
000311-45-5 DIETHYL-P-NITROPHENYL PHOSPHATE 000606-20-2
000319-85-7 HEXACHLOROCYCLOHEXANE, BETA 000608-93-5
000319-84-6 HEXACHLOROCYCLOHEXANE, ALPHA- 000608-73-1
000319-86-8 HEXACHLOROCYCLOHEXANE, DELTA- 000609-19-8
000329-71-5 DINITROPHENOL, 2,5- 000609-93-8
000330-55-2 LINURON 000610-39-9
000333-41-5 DIAZINON 000611-14-3
000460-19-5 CYANOGEN 000615-54-3
TRINITROPHENYLMETHYLNITRAMINE
TOLUENE-3,4-DIAMINE
AMINOPYRIDINE, 4-
SILVER CYANIDE
CHLORINE CYANIDE
POTASSIUM SILVER CYANIDE
CYANOGEN BROMIDE
BUTYLCHLORIDEJ-
CHLOROBENZILATE
TRIMETHYL PHOSPHATE
DIMETHYLPHENOL, 2,3-
DINITROBENZENE, 1,2-
FURIUM
DINITRO-0-CRESOL,4,6-
DICHLOROBENZENE, 1,3-
CYCLOPENTADIENE
BARIUM CYANIDE
DICHLOROPROPENE, 1,3-
BIS(CHLOROMETHYL) ETHER
COPPER CYANIDE
ZINC CYANIDE
THALLIUM ACETATE
DINITROPHENOL, 2,6-
DIMETHYLPHENOL, 2,6-
DICHLOROPHENOL
DICHLOROPHENOL, 2,5-
DINITROPHENOL, 3,5-
AMINOPHENOL, M-
DICHLOROPHENOL, 3,5-
HEXANONE, 2-
CALCIUM CYANIDE
DIMETHYLUREA, N,N-
TRICHLOROPROPANE, 1,1,2-
DINITROTOLUENE, 2,3-
DINITROTOLUENE, 2,6-
PENTACHLOROBENZENE
HEXACHLOROCYCLOHEXANE, TECHNICAL
TRICHLOROPHENOL, 3,4,5
DINITRO-P-CRESOL.2,6-
DINITROTOLUENE, 3,4
ETHYLTOLUENE, 0-
TRIBROMOBENZENE, 1,2,4-
-------
CASRN
TABLE A-III-1
NAME
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY CASRN) (continued)
CASRN
NAME
CASRN
NAME
U)
000617-84-5 DIETHYLFORMAMIDE 001563-66-2
000619-15-8 DINITROTOLUENE, 2,5- 001582-09-8
000620-14-4 ETHYLTOLUENE, M- ' 001600-37-9
000621-64-7 NITROSO-DI-N-PROPYLAMINE, N- 001615-80-1
000622-96-8 ETHYLTOLUENE, P- 001689-84-5
000624-83-9 METHYL ISOCYANATE 001689-99-2
000630-20-6 TETRACHLOROETHANE, 1,1,1,2- 001746-01-6
000630-08-0 CARBON MONOXIDE 001861-32-1
000630-10-4 SELENOUREA 001861-40-1
000634-93-5 TRICHLOROANILINE, 2,4,6- 001897-45-6
000636-21-5 METHYLANILINE HYDROCHLORIDE, 2- 001912-24-9
000684-93-5 METHYLNITROSOUREA 001918-16-7
000695-77-2 TETRACHLOROCYCLOPENTADIENE 001929-77-7
000759-73-9 ETHYLNITROSOUREA 001937-37-7
000759-94-4 EPTC . 002008-41-5
000764-41-0 DICHLORO-2-BUTENE, 1,4- 002014-83-7
000765-34-4 GLYCIDALDEHYDE 002077-46-5
000823-40-5 TOLUENE-2.6-DIAMINE 002104-96-3
000834-12-8 AMETRYN 002212-67-1
000924-16-3 NITROSO-DI-N-BUTYLAMINE, N- 002303-17-5
000930-55-2 NITROSOPYRROLIDINE, N- 002303-16-4
000933-75-5 TRICHLOROPHENOL, 2,3,6 002370-63-0
000933-78-8 TRICHLOROPHENOL, 2,3,5- 002385-85-5
000934-80-5 ETHYL-0-XYLENE, 4- 002425-06-1
000935-95-5 TETRACHLOROPHENOL, 2,3,5,6 002429-74-5
000950-10-7 MEPHOSFOLAN 002491-38-5
000957-51-7 DIPHENAMID 002602-46-2
000961-11-5 TETRACHLORVINPHOS (STIROFOS) 002610-05-1
001024-57-3 HEPTACHLOR EPOXIDE 002687-25-4
001114-71-2 PEBULATE 002921-88-2
001116-54-7 NITROSODIETHANOLAMINE, N- 003165-93-3
001134-23-2 CYCLOATE
001163-19-5 DECABROMODIPHENYL ETHER 003175-23-3
001309-64-4 ANTIMONY TRIOXIDE 003380-34-5
001314-32-5 THALLIC OXIDE
001314-84-7 ZINC PHOSPHIDE 003383-96-8
001314-62-1 VANADIUM PENTOXIDE 003689-24-5
001314-60-9 ANTIMONY PENTOXIDE 004399-55-7
001330-20-7 XYLENE, MIXTURE 004549-40-0
001332-81-6 ANTIMONY TETROXIDE 004901-51-3
001332-21-4 ASBESTOS 005216-25-1
001336-36-3 POLYCHLORINATED BIPHENYLS 006108-10-7
CARBOFURAN 006533-73-9
TRIFLURALIN 007429-90-5
PENTACHLOROPROPENE, 1,1,2,3,3- 007439-98-7
DIETHYLHYDRAZINE.1,2- 007439-97-6
BROMOXYNIL 007439-96-5
BROMOXYNIL OCTANOATE 007439-89-6
TCDD, 2,3,7,8- 007439-92-1
DACTHAL 007440-39-3
BENEFIN 007440-38-2
CHLORTHALONIL 007440-02-0
ATRAZINE 007440-66-6
PROPACHLOR 007440-43-9
VERNAM 007440-22-4
DIRECT BLACK 38 007440-41-7
BUTYLATE 007440-50-8
TRICHLOROTOLUENE, ALPHA,2,6- 007440-24-6
TRICHLOROTOLUENE, 2,3,6- 007440-36-0
BROMOPHOS 007440-62-2
MOLINATE 007440-42-8
TRIALLATE 007446-18-6
DIALLATE 007446-09-5
ETHOXYETHYL METHACRYLATE.2- 007446-34-6
MI REX 007637-07-2
CAPTAFOL 007664-93-9
NIAGARA BLUE 4B 007664-41-7
BUSAN 90 007723-14-0
DIRECT BLUE 6 007782-41-4
DIRECT SKY BLUE 6B . 007782-41-4
TOLUENE-2.3-DIAMINE 007782-49-2
CHLORPYRIFOS 007783-06-4
CHLORO-2-METHYLANILINE 007783-00-8
HYDROCHLORIDE, 4- 007789-89-1
TRICHLOROPROPANE, 1,2,2- 007791-12-0
TRICHLORO-2'-HYDROXYDIPHENYL ETHER, 007803-51-2
2,4,4'- . 008001-58-9
TEMEPHOS 008001-35-2
TETRAETHYL DITHIOPYROPHOSPHATE 008007-45-2
DIRECT LIGHTFAST BLUE 008018-01-7
NITROSOMETHYLVINYLAMINE, N- 010028-15-6
TETRACHLOROPHENOL, 2,3,4,5 010034-93-2
TETRACHLOROTOLUENE, P.a.a.a 010102-43-9
HEXACHLOROCYCLOHEXANE, EPSILON- 010102-45-1
THALLIUM CARBONATE
ALUMINUM
MOLYBDENUM
MERCURY (INORGANIC)
MANGANESE
IRON
LEAD
BARIUM
ARSENIC, INORGANIC
NICKEL (SOLUBLE SALTS)
ZINC (METALLIC)
CADMIUM
SILVER
BERYLLIUM
COPPER
STRONTIUM, STABLE
ANTIMONY (METALLIC)
VANADIUM
BORON
THALLIUM SULFATE
SULFUR DIOXIDE
SELENIUM SULFIDE
BORON.TRI FLUOR IDE
SULFURIC ACID
AMMONIA
PHOSPHORUS, WHITE
FLOUR IDE
FLUORINE
SELENIUM
HYDROGEN SULFIDE
SELENIOUS ACID
TRICHLOROPROPANE, 1,1,1,-
THALLIUM CHLORIDE
PHOSPHINE
CREOSOTE, COAL TAR
TOXAPHENE
COKE OVEN EMMISSIONS
MANCOZEB
OZONE
HYDRAZINE SULFATE
NITRIC OXIDE
THALLIUM(I) NITRATE
-------
CASRN
TABLE A-III-1
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY CASRN) (continued)
NAME
CASRN
NAME
CASRN
NAME
I
H
J^
010102-44-0 NITROGEN DIOXIDE
010436-39-2 TETRACHLOROPROPENE, 1.1,2.3
010595-95-6 NITROSOMETHYLETHYLAMINE, N-
012035-72-2 NICKEL SUBSULFIDE
012039-52-0 THALLIUM SELENITE
012122-67-7 ZINEB
012427-38-2 MANEB
013071-79-9 TERBUFOS
013194-48-4 ETHOPROP
013718-26-8 SODIUM METAVANADATE
014797-65-0 NITRITE
015950-66-0 TRICHLOROPHENOL. 2,3,4-
015972-60-8 ALACHLOR
016065-83-1 CHROMIUM(III)
016071-86-6 DIRECT BROWN 95
016752-77-5 METHOMYL
018540-29-9 CHROMIUM(VI)
020859-73-8 ALUMINUM PHOSPHIDE
021087-64-9 METRIBUZIN
021232-47-3 TETRACHLOROAZOXYBENZENE
021436-96-4 DIMETHYLANILINE HYDROCHLORIDE, 2.4-
021564-17-0 THIOCYANOMETHYLTHIOM)-
BENZOTHIAZOLE, 2-(
021725-46-2 CYANAZINE
022967-92-6 METHYL MERCURY
023950-58-5 PRONAMIDE
025013-15-4 METHYL STYRENE (MIXED ISOMERS)
025329-35-5 PENTACHLOROCYCLOPENTADIENE
026399-36-0 PROFLURALIN
030560-19-1 ACEPHATE
031512-74-0 BUSAN 77
032534-81-9 PENTABROMODIPHENYL ETHER
032536-52-0 OCTABROMODIPHENYL ETHER
033663-50-2 TRICHLOROANILINE HYDROCHLORIDE, 2.4,6-
033820-53-0 ISOPROPALIN
036907-42-3 VANADIUM SULFATE
039196-18-4 ' THIOFANOX
039638-32-9 BIS(2-CHLOROISOPROPYL) ETHER
040487-42-1 PENDIMETHALIN
041851-50-7 CHLOROCYCLOPENTADIENE
052125-53-8 PROPYLENE GLYCOL MONOETHYL ETHER
059756-60-4 FLURIDONE
060238-56-4 CHLORTHIOPHOS
068085-85-8 CYHALOTHRIN/KARATE
068554-00-7 ETHOXYETHANOL PHOSPHATED, 2-
071753-42-9 TETRACHLOROHYDRAZ08ENZENE
077323-84-3 TRICHLOROCYCLOPENTADIENE
TIN AND COMPOUNDS
THALLIUM (IN SOLUBLE SALTS)
LEAD ALKYLS
POLYBROMINATED BIPHENYLS
DINITROTOLUENE MIXTURE
NICKEL REFINERY DUST
BROMIMATED DIBENZOFURANS
-------
TABLE A-III-2.
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY CHEMICAL NAME)
i
H
Ul
NAME
ACENAPHTHENE
ACENAPHTHYLENE
ACEPHATE
ACETALDEHYDE
ACETONE
ACETONE CYANOHYDRIN
ACETONITRILE
ACETOPHENONE
ACROLEIN
ACRYLAMIDE
ACRYLIC ACID
ACRYLONITR1LE
ADIPONITRILE
ALACHLOR
ALDICARB
ALDRIN
ALLIDOCHLOR
ALLYL ALCOHOL
ALLYL CHLORIDE
ALUMINUM
ALUMINUM PHOSPHIDE
AHETRYN
AMINOPHENQL, M-
AMINOPHENOL, 0-
AMINOPHENOL, P-
AMINOPYRIDINE, 4-
AMMONIA
ANILINE
ANTHRACENE
ANTIMONY (METALLIC)
ANTIMONY PENTOXIDE
ANTIMONY POTASSIUM TARTRATE
ANTIMONY TETROXIDE
ANTIMONY TRIOXIDE
ARAMITE
ARSENIC, INORGANIC
ASBESTOS
ATRAZINE
AZOBENZENE
BARIUM
BARIUM CYANIDE
BENEFIN
BENZAL CHLORIDE
BENZ(A)ANTHRACENE
CASRN NAME
000083-32-9 BENZALDEHYDE
000208-96-8 BENZENE
030560-19-1 BENZIDINE
000075-07-0 BENZO(A)PYRENE
000067-64-1 BENZO(B)FLUORANTHENE
000075-86-5 BENZO(G,H,I)PERYLENE
000075-05-8 BENZOOOFLUORANTHENE
000098-86-2 BENZOIC ACID
000107-02-8 BENZOTRICHLORIDE
000079-06-1 BENZYL ALCOHOL
000079-10-7 BENZYL CHLORIDE
000107-13-1 BERYLLIUM
000111-69-3 BIPHENYL, 1,1'-
015972-60-8 BIS(2-CHLOROETHYL) ETHER
000116-06-3 BIS(2-CHLOROISOPROPYL) ETHER
000309-00-2 BIS(2-ETHYLHEXYL)PHTHALATE
000093-71-0 BIS(CHLOROMETHYL) ETHER
000107-18-6 BISPHENOL A
000107-05-1 BORON
007429-90-5 BORON TRIFLUORIDE
020859-73-8 BROMINATED DIBENZOFURANS
000834-12-8 BROMODICHLOROMETHANE
000591-27-5 BROMOFORM
000095-55-6 BROMOMETHANE
000123-30-8 BROMOPHENYLPHENYL ETHER, 4-
000504-24-5 BROMOPHOS
007664-41-7 BROMOXYNIL
000062-53-3 BROMOXYNIL OCTANOATE
000120-12-7 BUSAN 77
007440-36-0 BUSAN 90
001314-60-9 BUTADIENE, 1,3-
000304-61-0 BUTANOL, 1-
001332-81-6 BUTYL BENZYL PHTHLATE, N-
001309-64-4 BUTYLATE
000140-57-8 BUTYLCHLORIDE.T-
007440-38-2 BUTYROLACTONE, GAMMA-
001332-21-4 CACODYLIC ACID
001912-24-9 CADMIUM
000103-33-3 CALCIUM CYANIDE
007440-39-3 CAPROLACTAM
000542-62-1 CAPTAFOL
001861-40-1 CAPTAN
000098-87-3 CARBARYL
000056-55-3 CARBAZOLE
CASRN NAME CASRN
000100-52-7 CARBOFURAN 001563-66-2
000071-43-2 CARBON OISULFIDE 000075-15-0
000092-87-5 CARBON MONOXIDE 000630-08-0
000050-32-8 CARBON TETRACHLORIDE 000056-23-5
000205-99-2 CHLORAL 000075-87-6
000191-24-2 CHLORANIL 000118-75-2
000207-08-9 CHLORANILINE, P- 000106-47-8
000065-85-0 CHLORDANE 000057-74-9
000098-07-7 CHLORINE CYANIDE 000506-77-4
000100-51-6 CHLORO-1.3-BUTADIENE, 2- 000126-99-8
000100-44-7 CHLORO-M-CRESOL, P- 000059-50-7
007440-41-7 CHLORO-2-METHYLANILINE HYDROCHLORIDE, 4-
000092-52-4 003165-93-3
000111-44-4 CHLORO-2-METHYLANILINE, 4- 000095-69-2
039638-32-9 CHLOROACETIC ACID 000079-11-8
000117-81-7 CHLOROACETALDEHYDE 000107-20-0
000542-88-1 CHLOROANILINE, 2- 000095-51-2
000080-05-7 CHLOROANILINE, 3- 000108-42-9
007440-42-8 CHLOROANILINE, 4- 000106-47-8
007637-07-2 CHLOROBENZENE 000108-90-7
CHLOROBENZILATE 000510-15-6
000075-27-4 CHLOROBENZOIC ACID, P- 000074-11-3
000075-25-2 CHLOROBENZOTRIFLUORIDE, 4- 000098-56-6
000074-83-9 CHLOROBUTANE, 1- 000109-69-3
000101-55-3 CHLOROBUTANE, 2- 000078-86-4
002104-96-3 CHLOROCYCLOPENTADIENE 041851-50-7
001689-84-5 CHLORODIBROMOMETHANE 000124-48-5
001689-99-2 CHLOROFORM 000067-66-3
031512-74-0 CHLOROMETHANE 000074-87-3
002491-38-5 CHLOROMETHYL METHYL ETHER 000107-30-2
000106-99-0 CHLORONITROBENZENE, M- 000121-73-3
000071-36-3 CHLORONITROBENZENE, 0- 000088-73-3
000085-68-7 CHLORONITROBENZENE, P- 000121-73-3
002008-41-5 CHLOROPHENOL, 2- 000095-57-8
000507-20-0 CHLOROPHENOL, 3- 000108-43-0
000096-48-0 CHLOROPHENOL, 4- 000106-48-0
000075-60-5 CHLOROPROPANE, 2- 000075-29-6
007440-43-9 CHLOROTOLUENE, M- 000108-41-8
000592-01-8 CHLOROTOLUENE, 0- 000095-49-8
000105-60-2 CHLOROTOLUENE, P- 000106-43-4
002425-06-1 CHLORPYRIFOS 002921-88-2
000133-06-2 CHLORTHALONIL 001897-45-6
000063-25-2 CHLORTHIOPHOS 060238-56-4
000086-74-8 CHROMIUMd 11) 016065-83-1
-------
TABLE A-111-2.
NAME
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY CHEMICAL NAME) (Continued)
CASRN
NAME
CASRN
NAME
CASRN
a\
CHROMIUH
-------
TABLE A-111-2.
NAME
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY CHEMICAL NAME) (Continued)
CASRN
NAME
CASRN
NAME
CASRN
ETHOXYETHANOL PHOSPHATE, 2-
ETHOXYETHYL ACRYLATE,2-
ETHOXYETHYL METHACRYLATE,2-
ETHYL ACETATE
ETHYL ACRYLATE
ETHYL CHLORIDE
ETHYL ETHER
ETHYL METHACRYLATE
ETHYL-0-XYLENE, 4-
ETHYLANILINE, N-
ETHYLBENZENE
ETHYLENE CYANOHYDRIN
ETHYLENE DIAMINE
ETHYLENE GLYCOL
ETHYLENE GLYCOL MONOBUTYL ETHER
ETHYLENE OXIDE
ETHYLENE THIOUREA
ETHYLNITROSOUREA
ETHYLTOLUENE, M-
ETHYLTOLUENE, 0-
ETHYLTOLUENE, P-
FLUORANTHENE
FLUORENE
FLOUR IDE
FLUORINE
FLURIDONE
FOLPET
FORMALDEHYDE
FORMALDEHYE CYANOHYDRIN
FORMIC ACID
FURAN
FURAZOLIDONE
FURFURAL
FURIUM
GLYCIDALDEHYDE
HEPTACHLOR
HEPTACHLOR EPOXIDE
HEPTANE, N-
HEXABROMOBENZENE
HEXACHLOROBENZENE
HEXACHLOROBUTADIENE
HEXACHLOROCYCLOHEXANE, ALPHA-
068554-00-7 HEXACHLOROCYCLOHEXANE, BETA
000106-74-1 HEXACHLOROCYCLOHEXANE, DELTA-
002370-63-0 .HEXACHLOROCYCLOHEXANE, EPSILON-
000141-78-6 HEXACHLOROCYCLOHEXANE, GAMMA-
000140-88-5 HEXACHLOROCYCLOHEXANE, TECHNICAL
000075-00-3 HEXACHLOROCYCLOPENTADIENE
000060-29-7 HEXACHLOROETHANE
000097-63-2 HEXACHLOROPHENE
000934-80-5 HEXAMETHYLENE DIAMINE
000103-69-5 HEXANE, N
000100-41-4 HEXANONE, 2-
000109-78-4 HYDRAZINE
000107-15-3 HYDRAZINE SULFATE
000107-21-1 HYDROGEN SULFIOE
000111-.76-2 HYDROQUINONE
000075-21-8 INDENO(1,2,3-CD)PYRENE
000096-45-7 IRON
000759-73-9 ISOBUTYL ALCOHOL
000620-14-4 ISOPHORONE
000611-14-3 ISOPROPALIN
000622-96-8 LACTONITRILE
000206-44-0 LEAD
000086-73-7 LEAD ALKYLS
007782-41-4 LINURON
007782-41-4 MALATHION
059756-60-4 MALEIC ANHYDRIDE
000133-07-3 MALEIC HYDRAZIDE
000050-00-0 MALONONITRILE
000107-16-4 MANCOZEB
000064-18-6 MANEB
000110-00-9 MANGANESE
000067-45-8 MEPHOSFOLAN
000098-01-1 MERCURY (INORGANIC)
000531-82-8 MERPHOS
000765-34-4 MERPHOS OXIDE
000076-44-8 METHACRYLONITRILE
001024-57-3 METHANOL
000142-82-5 METHOMYL
000087-82-1 METHOXY-5-NITROANILINE, 2-
000118-74-1 METHOXYCHLOR
000087-68-3 METHOXYETHANOL, 2-
000319-84-6 METHOXYETHANOL ACETATE, 2-
000319-85-7
000319-86-8
006108-10-7
000058-89-9
000608-73-1
000077-47-4
000067-72-1
000070-30-4
000124-09-4
000110-54-3
000591-78-6
000302-01-2
010034-93-2
007783-06-4
000123-31-9
000193-39-5
007439-89-6
000078-83-1
000078-59-1
033820-53-0
000078-97-7
007439-92-1
METHYL
METHYL
METHYL
METHYL
METHYL
METHYL
METHYL
METHYL
METHYL
METHYL
METHYL
METHYL
METHYL
METHYL
METHYL
METHYL
METHYL/
METHYL/
METHYL!
METHYLI
5-NITROANILINE, 2-
ACETATE
ACRYLATE
CHLOROCARBONATE
ETHYL KETONE
HYDRAZINE
ISOBUTYL KETONE
ISOCYANATE
MERCURY
METHACRYLATE
PARATHION
STYRENE, ALPHA-
STYRENE (MIXED ISOMERS)
4-CHLOROPHENOXYACETIC ACID, 2-
4-CHLOROPHENOXY)BUTYRIC ACID, 4-
4-CHLOROPHENOXY)PROPIONIC ACID, 2
000099-
000079-
000096-
000079-
000078-
000060-
000108-
000624-
022967-
000080-
000298-
000098-
025013-
000094-
000094-
-(2-
000093-
000095-
000636-
000056-
55-8
20-9
33-3
22-1
93-3
34-4
10-1
83-9
92-6
62-6
00-0
83-9
15-4
74-6
81-5
65-2
53-4
21-5
49-5
000101-14-4
METHYLANILINE HYDROCHLORIDE, 2-
METHYLCHLOLANTHRACENE, 3-
METHYLENE-BIS-(2-CHLOROANILINE), 4,4'-
METHYLENE-BIS(N,N-DIMETHYL) ANILINE, 4,4'
000330-55-2 000101-61-1
000121-75-5 METHYLENE BROMIDE 000074-95-3
000108-31-6 METHYLENE CHLORIDE 000075-09-2
000123-33-1 METHYLENEBISBENZENAMINE, 4,4'- 000101-77-9
000109-77-3 METHYLENEDIPHENYL ISOCYANATE, 4,4'- 000101-68-8
008018-01-7 METHYLNITROSOUREA 000684-93-5
012427-38-2 METRIBUZIN 021087-64-9
007439-96-5 MI REX 002385-85-5
000950-10-7 MOLINATE 002212-67-1
007439-97-6 MOLYBDENUM 007439-98-7
000150-50-5 NAPHTHALENE 000091-20-3
000078-48-8 NAPHTHOQUINONE 000130-15-4
000126-98-7 NIAGARA BLUE 4B 002429-74-5
000067-56-1 NICKEL (SOLUBLE SALTS) 007440-02-0
016752-77-5 NICKEL REFINERY DUST
000099-59-2 NICKEL SUBSULFIDE 012035-72-2
000072-43-5 NICOTINONITIRLE 000100-54-9
000109-86-4 NITRIC OXIDE 010102-43-9
000110-49-6 NITRITE 014797-65-0
-------
NAHE
TABLE A-111-2.
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY CHEMICAL NAME) (Continued)
CASRN
NAME
CASRN
NAME
CASRN
I
H
CO
NITROANILINE, M-
NITROANILINE, 0-
NITROANILINE, P-
NITROBENZENE
NITROFURANTOIN
NITROFURAZONE
NITROGEN DIOXIDE
NITROMETHANE
NITROPROPANE, 2-
NITROSO-DI-N-BUTYLAMINE; N-
NITROSO-DI-N-PROPYLAM1NE, N-
NITROSODIETHANOLAMINE, N-
NITROSODIETHYLAMINE, N-
NITROSODIMETHYLAMINE. N-
NITROSODIPHENYLAMINE, N-
NITROSOMETHYLETHYLAMINE, N-
NITROSOMETHYLVINYLAMINE, N-
NITROSOPYRROLIDINE, N-
NITROTOLUENE, M-
NITROTOLUENE, 0-
NITROTOLUENE, P-
OCTABROHOOIPHENYL ETHER
OCTANE T HYLPYROPHOSPHORAMIDE
OZONE
PARALDEHYDE
PARATHION
PEBULATE
PENDIMETHAL1N
PENTABROMO-6-CHLORO-CYCLOHEXANE,
PENTABROMODIPHENYL ETHER
PENTACHLOROBENZENE
PENTACHLOROCYCLOPENTADIENE
PENTACHLORONITROBENZENE
PENTACHLOROPHENOL
PENTACHLOROPROPENE, 1.1,2,3,3-
PENTANE, N-
PHENANTHRENE
PHENOL
PHENYLENEDIAMINE, M-
PHENYLENEDIAMINE, 0-
PHENYLENEDIAMINE, P-
PHENYLMERCURIC ACETATE
000099-09-2
000088-74-4
000100-01-6
000098-95-3
000067-20-9
000059-87-0
010102-44-0
000075-52-5
000079-46-9
000924-16-3
000621-64-7
001116-54-7
000055-18-5
000062-75-9
000086-30-6
010595-95-6
004549-40-0
000930-55-2
000099-08-1
000088-72-2
000099-99-0
032536-52-0
000152-16-9
010028-15-6
000123-63-7
000056-38-2
001114-71-2
040487-42-1
1,2,3,4/HK)087-84-3
032534-81-9
000608-93-5
025329-35-5
000082-68-8
000087-86-5
001600-37-9
000109-66-0
000085-01-8
000108-95-2
000108-45-2
000095-54-5
000106-50-3
000062-38-4
PHENYLPHENOL, 2- 000090-43-7
PHORATE 000298-02-2
PHOSGENE 000075-44-5
PHOSPHINE 007803-51-2
PHOSPHORUS, WHITE 007723-14-0
PHTHALIC ACID, M- 000121-91-5
PHTHALIC ACID, 0- 000088-99-3
PHTHALIC ACID, P- 000100-21-0
PHTHALIC ANHYDRIDE 000085-44-9
POLYBROMINATED BIPHENYLS
POLYCHLORINATED BIPHENYLS 001336-36-3
POTASSIUM CYANIDE 000151-50-8
POTASSIUM SILVER CYANIDE 000506-61-6
PROFLURALIN 026399-36-0
PRONAMIDE 023950-58-5
PROPACHLOR 001918-16-7
PROPAZINE 000139-40-2
PROPIONITRILE 000107-12-0
PROPYL ALCOHOL, N- 000071-23-8
PROPYLENE GLYCOL 000057-55-6
PROPYLENE GLYCOL MONOETHYL ETHER 052125-53-8
PROPYLENE GLYCOL MONOMETHYL ETHER 000107-98-2
PROPYLENE OXIDE 000075-56-9
PYRENE 000129-00-0
PYRIDINE 000110-86-1
QUINOLINE 000091-22-5
RDX (CYCLONITE) 000121-82-4
RONNEL 000299-84-3
SELENIOUS ACID 007783-00-8
SELENIUM 007782-49-2
SELENIUM SULFIDE 007446-34-6
SELENOUREA 000630-10-4
SILVER 007440-22-4
SILVER CYANIDE 000506-64-9
SIMAZINE 000122-34-9
SODIUM CYANIDE 000143-33-9
SODIUM DIETHYLDITHIOCARBAMATE 000148-18-5
SODIUM FLUOROACETATE 000062-74-8
SODIUM METAVANADATE 013718-26-8
STRONTIUM, STABLE 007440-24-6
STRYCHNINE 000057-24-9
STYRENE 000100-42-5
SUCCINONITRILE 000110-61-2
SULFUR DIOXIDE 007446-09-5
SULFURIC ACID 007664-93-9
TCDD, 2,3,7,8- 001746-01-6
THIOCYANOMETHYLTHION)-BENZOTHIAZOLE, 2-( 021564-17-0
TEMEPHOS 003383-96-8
TERBUFOS 013071-79-9
TEREPHTHALIC ACID 000100-21-0
TETRACHLOROAZOXYBENZENE
TETRACHLOROBENZENE, 1,2,4,5-
TETRACHLOROCYCLOPENTADIENE
TETRACHLOROETHANE, 1.1.1,2-
TETRACHLOROETHANE, 1,1,2,2-
TETRACHLOROETHYLENE, 1,1,2,2-
TETRACHLOROHYDRAZOBENZENE
TETRACHLOROPHENOL, 2,3,4,5
TETRACHLOROPHENOL, 2,3,4.6-
TETRACHLOROPHENOL, 2,3,5,6
TETRACHLOROPROPENE, 1,1,2,3
TETRACHLOROTOLUENE, P,er,er,er
TETRACHLORVINPHOS (STIROFOS)
TETRAETHYL DITHIOPYROPHOSPHATE
THALLIC OXIDE
THALLIUM ACETATE
THALLIUM CARBONATE
THALLIUM CHLORIDE
THALLIUM (IN SOLUBLE SALTS)
THALLIUM(I) NITRATE
THALLIUM SELENITE
THALLIUM SULFATE
THIOFANOX
THIRAM
TIN AND COMPOUNDS
TOLUENE
TOLUENE-2.3-DIAMINE
TOLUENE-2,5-01AMINE
TOLUENE-2.6-DIAMINE
TOLUENE-3.4-DIAHINE
TOLUIDINE, M
TOLUIDINE, P-
021232-47-3
000095-94-3
000695-77-2
000630-20-6
000079-34-5
000127-18-4
071753-42-9
004901-51-3
000058-90-2
000935-95-5
010436-39-2
005216-25-1
000961-11-5
003689-24-5
001314-32-5
000563-68-8
006533-73-9
007791-12-0
010102-45-1
012039-52-0
007446-18-6
039196-18-4
000137-26-8
000108-88-3
002687-25-4
000095-70-5
000823-40-5
000496-72-0
000108-44-1
000106-49-0
-------
TABLE A-III-2.
CHEMICAL NAME AND CHEMICAL ABSTRACTS SERVICE REGISTRY NUMBER CROSS REFERENCE
(LISTED BY CHEMICAL NAME) (Continued)
NAME
CASRN
NAME
CASRN
NAME
CASRN
TOXAPHENE 008001-35-2
TRIALLATE 002303-17-5
TRIBROM08ENZENE, 1,2,4- 000615-54-3
TRICHLORO-1,2,2-TRIFLUOROETHANE, 1,1,2-
000076-13-1
TRICHLORO-2'-HYDROXYDIPHENYL ETHER, 2,4,4'
TRICHLOROAMILINE, 2,4,6-
TR1CHLOROANILINE HYDROCHLORIOE, 2,4,6-
TRICHLOROBENZENE, 1,2,4-
TRICHLOROCYCLOPENTADIENE
TRICHLOROETHANE, 1,1.1-
TRICHLOROETHANE, 1,1,2-
TRICHLOROETHYLENE
TRICHLOROFLUOROMETHANE
TRICHLOROPHENOL, 2,3,4-
TRICHLOROPHENOL, 2,3,5-
TRICHLOROPHENOL, 2,3,6
TRICHLOROPHENOL, 2,4,5-
TRICHLOROPHENOL, 2,4,6-
TRICHLOROPHENOL, 3,4,5
TRICHLOROPHENOXY) PROP ION 1C ACID, 2(2,4
TRICHLOROPHENOXYACETIC ACID, 2,4,5-
TRICHLOROPROPANE, 1,1,1,-
TRICHLOROPROPANE,
1,1,2-
1,2,2-
1,2,3-
1,2,3-
TRICHLOROPROPANE,
TRICHLOROPROPANE,
TRICHLOROPROPENE,
TRICHLOROTOLUENE, 2,3,6-
TRICHLOROTOLUENE, ALPHA,2,6-
TRI PLURAL IN
TRIMETHYL PHOSPHATE
TRINITROBENZENE, 1,3,5-
TRINITROPHENYLMETHYLNITRAMINE
TRINITROTOLUENE, 2,4,6-
VANADIUM
VANADIUM PENTOXIDE
VANADIUM SULFATE
VERNAM
VINYL ACETATE
003380-
000634-
033663-
000120-
077323-
000071-
000079-
000079-
000075-
015950-
000933-
000933-
000095-
000088-
000609-
,5-
000093-
000093-
007789-
000598-
003175-
000096-
000096-
002077-
002014-
001582-
000512-
000099-
000479-
000118-
007440-
001314-
036907-
001929-
000108-
34-5
93-5
50-2
82-1
84-3
55-6
00-5
01-6
69-4
66-0
78-8
75-5
95-4
06-2
19-8
72-1
76-5
89-1
77-6
23-3
18-4
19-5
46-5
83-7
09-8
56-1
35-4
45-8
96-7
62-2
62-1
42-3
77-7
05-4
VINYL CHLORIDE
VINYL-1-CYCLOHEXENE
WARFARIN
XYLENE, M-
XYLENE, MIXTURE
XYLENE, 0-
XYLENE, P-
ZINC (METALLIC)
ZINC CYANIDE
ZINC PHOSPHIDE
ZINEB
000075-01-4
000100-40-3
000081-81-2
000108-38-3
001330-20-7
000095-47-6
000106-42-3
007440-66-6
000557-21-1
001314-84-7
012122-67-7
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A-20
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APPENDIX A-IV
IV. EFFECT LEVEL DEFINITIONS
Adverse effect. A biochemical change, functional impairment, or
pathologic lesion that either singly or in combination adversely
affects the performance of the whole organism, or reduces an
organism's ability to respond to an additional environmental
challenge.
Frank-effect-level (FED. The exposure level at which there are
statistically or biologically significant increases in frequency or
severity of severe effects between the exposed population and its
approriate control group. These severe effects produce an
unmistakable adverse health effect (such as severe convulsions or
death).
Lowest-observed-adverse-effect level (LOAEL). The lowest exposure
level at which there are statistically or biologically significant
increases in frequency or severity of adverse effects between the
exposed population and its appropriate control group.
Lowest-observed-effect level (LOEL). The lowest exposure level at
which there are statistically or biologically significant increases
in frequency or severity of any effects between the exposed
population and its appropriate control group. The effects that are
seen at this level may or may not be considered as adverse.
No-observed-adverse-effect level (NOAEL). An exposure level at
which there are no statistically or biologically significant
increases in the frequency or severity of adverse effects between
the exposed population and its appropriate control; some effects
may be produced at this level, but they are not considered to be
adverse.
No-observed-effect level (NOEL). An exposure level at which there
are no statistically or biologically significant increases in the
frequency or severity of any effect between the exposed population
and its appropriate control.
Adapted from: U.S. EPA. 1991. Integrated Risk Information System
(IRIS). Online. Office of Health and Environmental Assessment,
Environmental Criteria and Assessment Office, Cincinnati, OH.
A-21
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A-22
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APPENDIX A-V
V. NATIONAL AMBIENT AIR QUALITY STANDARDS (NAAQS)
The Clean Air Act requires that National Ambient Air Quality
Standards (NAAQS) be set and ultimately met for any air pollutant
which, if present in air, may reasonably be anticipated to endanger
public health or welfare and whose presence in the air results from
numerous or diverse mobile and/or stationary sources. Since the
primary NAAQS and the inhalation RfC serve essentially the same
function, and the primary NAAQS have extensive data bases
rigorously reviewed, the primary NAAQS with annual averaging times
should be used in lieu of an inhalation RfC. Primary standards are
designed to protect public health and secondary standards are
designed to protect public welfare. Each primary NAAQS has either
one or two averaging times depending on the health effects of the
chemical. To date, six NAAQS have been established: Carbon
monoxide (CO), Lead (Pb), Nitrogen dioxide (NO2) , Particulate
matter, less than 10 jLtm in size, (PM10) , Ozone (O3) and Sulfur
dioxide (SO2) . A table of the most recent NAAQS is provided as
Table A-V-1.
The process of establishing and revising the NAAQS is detailed
by Padgett and Richmond (Journal of the Air Pollution Control
Association, 33:13-16, 1983). The primary NAAQS are solely health
based and designed to protect the most sensitive group of
individuals (but not necessarily the most sensitive members of that
group) against adverse health effects. Thus, by definition, the
NAAQS primary standards define allowable pollutant concentrations
which can be present in the atmosphere without causing adverse
effec.ts, and essentially serve the same function as an inhalation
RfC in a risk assessment/risk management decision. The data bases
supporting each of the NAAQS are extensive. More importantly, the
NAAQS are set by the USEPA Administrator as mandated by Congress
after numerous reviews and a public comment process.
A-23
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TABLE A-V-1
NATIONAL AMBIENT AIR QUALITY STANDARDS
(as of December 2, 1991 )a
Pollutant
Carbon monoxide (CO)
Lead (Pb)
(and Lead compounds)
Nitrogen dioxide
(N02)
(Nitrogen oxide)
(Nitric oxide)
Particulate matter
(PM10)
Ozone (O3)
Sulfur dioxide (SO2)
(Sulfur oxide)
Primary Standards13
9 ppm (10 mg/m3)
35 ppm (40 mg/m3)
1.5 Jig/m3
0.053 ppm
(100 jig/™3)
50 jig/m3
150 jig/m3
0.12 ppm
(235 jig/m3)
0.03 ppm
(80 lig/m3)
0.14 ppm
(365 jig/m3)
Averaging
Time
8 hours0
1 hour0
Quarterly
Annual
Annuald
24 hours6
1 hourf
Annual
24 hours0
3 hours0
Secondary
Standards13
None
Same as primary
Same as primary
Same as primary
Same as primary
0 . 5 ppm
(1300 ng/m3)
aSource: U.S. EPA. 1991. Subchapter C - Air Programs. Part 50 - National
Primary and Secondary Ambient Air Quality Standards. Code of Federal
Regulations 50: 693-697. Revised 7/1/91.
bPrimary standards are designed to protect public health; Secondary standards
are designed to protect public welfare.
°Not to be exceeded more than once per year.
dThe standard is attained when the expected annual arithmetic mean concentration
is less than or equal to 50 ng/m3.
eThe standard is attained when the expected number of days per calendar year
with a 24-hour average concentration above 150 jig/m3 is equal to or less
than 1.
£The standard is attained when the expected number of days per calendar year
with maximum hourly average concentrations above 0.12 ppm is equal to or less
than 1.
A-24
* U.S. G.P.O.:1992-311-893:60472
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