UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
                                 WASHINGTON, O.C. 20460
                                    JUH 11 1998
                                                                        off tee of
                                                                    PM6VEMT1QN. PESTICIDES
                                                                    AND fOXC SUBSTANCES
 MEMORANDUM:

 SUBJECT; Office of Pesticide Programs List of Chemicals Evaluated for Carcinogenic Potential

 FROM:   William L. Burham, Chief   }*JL  <3/xT>"~-^
           Science Analysis Branch    \JW Q* U
           Health. Effects Division (7509C)

 TO:      Division Director HED, RD, SRRD and EFED
          Associate Directors, HED
          Branch Chiefs, HED

 The attached list provides a quick overview-of compounds evaluated for carcinogenicity by the
 Health Effects Division (HED) of the Office of Pesticide Programs (OPP). Chemicals evaluated by
 other review groups are listed as welt and HED looks to these evaluations until an internal HED
 evaluation has been performed. • Since the evaluation of many of these chemicals is an ongoing
 process, the  information OQ this list may'change ami become put of date, i.e., the classification and
 Qi* may change. Therefore, the list should not be used as the sole reference, without checking on
 the. present status of a compound.  Updated lists will be distributed in the future on a semi-annual
 basis.

 Unless otherwise indicated, the classification of chemicals istased on the HED carcinogenicity
 peer review  process or the HED hazard identification assessment review process, applying the
 Agency guidelines for carcinogenicity assessment.  Evaluations by other groups are indicated by
their acronyms:  Cancer Assessment-Group (CAG), Carcinogen Risk Assessment Verification
 Endeavor (CRAVE), International Agency for Research on Cancer, World Health Organization
 (IARC), Office of Research and Development, U.S. EPA (ORDX Scientific Advisory Board (SAB)
 and FIFRA Scientific Advisory Panel (SAP). For those chemicals where different.groups
suggested different classifications, the "final" OPP classification is listed under the column
"Current OPP Classification".  The Potency (Qi*), unless otherwise indicated, is based on the oral
route. The units for the oral and inhalation Qi* are (mg/kg/day) 'l and (ug/cu.m) "', respectively.

If any corrections are necessary or further information is required please contact Rick Whiting
(703-305-5473) or myself (703-305-6193).

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DATE: 05/27/98
             OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                            PAGE:   1
           CHEMICAL
  CURRENT OPP
CLASSIFICATION
         TUMOR TYPE / SPECIES
POTEMCT Q* I   SAP
  VALUE    I  CLASS
CRAVE
CLASS
COMMENTS
2,4-0
  CAS No. 94-75-7
  EPA Chm Codes 030001

2-Benzyl-4-chlorophenol
  CAS No. 120-32-1
  EPA Chat Code: 062201
 AC 263222 (Cadre herbicide)
   CAS No. 81534-60-3
   EPA CheavCode: 129041
 AC 2V9.263
   CAS No. 11431-32-9
   EPA Che* Code: 129171

 Acephat*
   CAS No. 30560-19-1
   EPA Chea Code: 103301

 Acetaldehyde
   CAS No. 75-07-0
   EPA Chen Code: 202300

 Acetamide
   CAS No. 60-35-5
   EPA Che* Code:

 Acetochlor
   CAS No. 342S6-B2-1
   EPA Che* Code: 121601
 Acetone
   CAS No. 67-64-1
   EPA Chen Code: 044101
 Acetophenone
   CAS No. 98-86-2
   EPA Chen Code: 129033
 Acifluorfen, sodfun
   CAS No. 62476-59-9
   EPA Ch«m Code:  121601
Not Likely
 12 (CRAVE)
 •2
                                0 (CRAVE)
                                0 (CRAVE)
                                62
                 Brain astrocytOMs; F344/CrL-Br rate  (M)
                 Renal tubule cabined adenonas/carciriosm;
                 MC3F1 alee (N).
                 Renal transitional cell carcinomas;  F344/N
                 rat* (F).
                 Hepatocetlular carclnoa**; CD-I arice (F)
I Nasal tuaors;  SPF Wlstar rata (M ft F).
I Laryngeal tuaors; Syrian Golden hearten
I (M ft F).

  Liver (MOTS;  WUtar rate  IB); F344 rata
  (N ft F).
  Natal eplthslius adenoe»ft. thyroid cell
  adenoM. benign chondra of femur, basal
  cell tuaor of stcnMch; CD rate (N ft F).
  Pulswnsry adenoaws (M ft F);  liver tusors
  (M); CO-1 BJlea.
                 Liver; B6C3F1 ft CO-1 nice (M ft F).
                 Stomach paplUwmw; B6C3F1 nice (M ft F).
                                                             2.2 E-6 (I)
                                                              1.69 E-2
                                                                                    B2
                                                                                    Pend.
                                                                                             1.07E-1
                                                                           B2/C
                                                                            Clasetfication pending repeat of studies I
                                                                            additional  epfdenfological data.
                                                                            [Syn.  2,4-Dichlorophenoxyacetic acid]

                                                                            tSyn.  OBCP, o-Benzyl-p-chlorophenol]
                                                                                           Studies were conducted usfng the free acid
                                                                                           fona of AC 263222.  The PC Code C CASRH  for
                                                                                           the anmonitn salt is 128943 t 104098-49-9.
                                                                                           respectively.
                                                                                           CRAVE Q* * B.7 E-3 (0).
                             This assessment is located on IRIS. OPP has
                             not reviewed this chariest.
                                                                                           AcetMtde (not itself a pettfclde)  is a meta-
                                                                                           bolite of pesticides Nethomyl  ft Thiodicarb.
                                                                            AssessiRent  based on  lack of data concerning
                                                                            csrcinogenlcity in humans or animals.
                                                                            This atsessnent is located on IRIS.  OPP has
                                                                            not reviewed this chemical.

                                                                            Assessment  based on.  lack of data concerning
                                                                            csrcinogenlcity in humans or animals.
                                                                            This assessment is located on IRIS.  OPP has
                                                                            not reviewed this chemical.

                                                                    Pend. I Syn. Tackle ft Blazer

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DATE: 05/27/98
             OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                             PAGE:  2
           CHEMICAL
  CURRENT OPP
CLASSIFICATION
        TUMOR TYPE / SPECIES
 POTENCY Q* I  SAP   I CRAVE
   VALUE      CLASS  I CLASS
                                                                                                                                              COMMENTS
Acrlrathrtn
  CAS Ho. 101007-06-V
  EPA Che» Code:  129141

Acrolefn
  CAS No. 107-02-8
  EPA Chew Code:  000701
Hery I amide
  CAS  No.  79-06-1
  EPA  Chem Code:  600008
 Acrylonitcile
   CAS No. 107-13-1
   EPA Chen Code: 000601
 Alechlor
   CAS No. 15972-60-8
   EPA Chem Code: 090501

 Aldicarb (Temik)
   CAS No. 116-06-3
   EPA Che* Code: 098301
 Aldrln
   CAS No. 309-00-2
   EPA Chem Code:  045101
  Amlnopyridine,  4-
   CAS  No.  504-24-5
   EPA  Chen Code: 069203
  Amltraz (Bam)
    CAS No.  33089-61-1
    EPA Chen Code:  106201
  Amitrole
    CAS No. 61-82-5
    EPA Chem Code: 004401
B2 (CRAVE)
 •1  (CRAVE)
 Likely (high
 doses)
 Not likely

 D (CRAVE)
                                B2 (CRAVE)
                                0  (CRAVE)
 82
 2B (IARC)
                                          ; Fischer 344
Adrenal cortical
rate (F).
Benign i/or malignant tutors at Multiple
•ite* in M * F rats (F344), i carcinogenic
effect* in a series of 1-year United blo-
btoasssys in alee (SENCAR. Swiss-ICR I A/J
strains) fay several routes of exposures.

Significant Increase  in  Incidence of lung
cancer In exposed workers t observation of
.tutors, generally astrocytosms  In the
brain, in 2 rat strains  exposed by various
routes (Mater, gavaga. inhalation).

Malignant A combined  benign/malignant
•ultlpte tumr types  in  both sexes; Long
Evans rat

Significant trend In  pituitary  tusor; Fi44
rats (f).  Signfleant trend in  fibrosar-
       B6C3F1 »lce  (M).
                  Liver csrclnoMs;  CJHeB/Fe Mice  (N t F);
                  Hepatic hyperlasia I begnign hepatoMs;
                  C3H Bice  (N *  F);  Hepatocellular carcin-
                  omas; B6C3F1 Mice  (N).
 Lynphoreticular tunors;  CfLP mice (f);
 Hepatocellular adenonas. carcinomas t
 adenomas/earcinomBB combined;  B6C3F1 «ice
 
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DATE: 05/27/98
             OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                             PAGE:  I
           CHEMICAL
                                  CURRENT OPP
                                CLASSIFICATION
                         TUMOR TYPE / SPECIES
                                              POTENCY 0* I   SAP    I CRAVE
                                                VALUE    I  CLASS   I CLASS
                                                                                                              CONKENTS
Aniline
  CAS No. 62-53-3
  EPA Cham  Cod*:  251400

Aramite
  CAS No. 140-57-8
  EPA ChM  Code:  062501
82 (CRAVE)
82 (CRAVE)
  CAS No.  3337-71-1
  EPA. Chen Code: 106901

Atrazine
  CAS Mo.  1912-24-9
  EPA Cheat Code: 080803

Averiaecttn 81
  CAS No.  65195-55-3
  EPA Chen Code: 122804

Azinphoa-methyl (Guthlon)
  CAS Ho.  86-50-0
  EPA Cheat Code: 058001

Azobenzene
  CAS No.  103-33-3
  EPA Chew Code: 007401
 Azoxyatrobfn
   CAS No. 131860-33-8
   EPA Chen Code: 128810

 Berdac 22 (alao 2250, 2280)
   CAS NO. 7173-51-5
   EPA Chem Code: 069149

 Baygon (Proponur)
   CAS NO. 114-26-1
   EPA Cheai Code: 047802
 Befionyl
   CAS No.  17804-35-2
   EPA Cheat Code: 099101
C(q)
28 (IARC)
82 (CRAVE)
Not Likely
82
                                C(q)
Induction.of tumors of the spleen end the
body cavity In 2 etreim of rat 1CO-F A
riacher 344).

Liver tumora i/or neoplaatic nodule* In
3 atralna of N t f rata (FDRL, CFN (
Oeborne-Mendel) C M of one atrain of mice
.

Maasairy tuaora (flbroadenoma/edenocarelno-
•as); Spregue-Dauley rata (F).
5.7 E-3
2.5 E-2 (0)
7.1 E-6 (!)
82
82
                                                              2.22 E-1
                       Pend.
Invaalve aarcomaa In the apleen • other
abdaailnal organs; F344 rata (M & F).
1.1 E-1 (0)
3.1 E-5 
                                                                                    82
Bladder careinomaa (rare), papillamas A
coafalned earcinona/papillom (NSF); Wiatar
rata.  Statistically significant increases
in hepatocellular adenomas t combined ade-
naaa/carcinoM; 86C3F1 nice (M).

Liver tumors (hepatoceltular adenomas I
carcinoma) in 2 genetically related
strains of Mice (CO-1 * Swiss SPF) (M t, f\
                                                              3.69 E-3
                                                                                              4.2 E-3
                                                                                    Pend.
                              This assessment  la  located on IRIS,  opp has
                              not reviewed  thta chemical.
Thia assessment ia located on IRIS.   OPP has
not reviewed thla chemical.
                                                                                            Repeat of rat carcinogenicity study is
                                                                                            requested.
        Atobena ia genotoxic t may be converted to
        benxldine, a known huaan carcinogen, under
        the acidic conditions  in the stomach.
        Thia assessment  ia located on IRIS.  OPP ha
        not reviewed this  chemical.
                              MCPRC recommended the low dose extrapolation
                              model applied to the animal  data be used for
                              the quantification of human risk (01*).
                                                                                            Benonyl rapidly hydrolyses  to MBC in an
                                                                                            aqueous environment.  MBC also appears to be
                                                                                            the Initial metabolite  in mammalian systems.
                                                                                            MBC has similar or increased toniclty, both
                                                                                            acute t chronic, to Benonyl.

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DATE: 05/27/98
                                            OFFICE OF PESTICIDE PROGRAMS  LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                              PACE:  4
           CHEMICAL
  OMREN1 Off
CLASSIFICATION
                                                         TIMOR TYPE / SPECIES
                                              POTENCY Q*
                                                VALUE
               SAP
              CLASS
CRAVE
CLASS
                                                                                                                                              COMMENTS
Benoxacor
  CAS No. 98730-04-2
  EM Ottm  Code:
Bentazon (Basagran)
  CAS No. 25057-89-0
  EPA ChM Code: 275200

Benzene
  CAS No. 71-*3-2
  EPA Chen Code: 008801
 Benzole acid
   CAS No. 65-85-0
   EPA Chen Code: 009101
 Blfenthrln (Talatar)
   CAS No. 83657-04-3
   EPA Che* Code! 128825
 Biphenyl, 1.1-
   CAS No. 92-52-4
   EPA Chen Code: 017002
 Bfm(chloroethyl)ether (BCEE)
   CAS No.  111-14-4
   EPA Chen Code:  029501

 Borax
   CAS No.  1303-96-4
   EPA Che* Code:  011102

 Boric acid
   CAS No.  10043-35-3
   EPA Chen Code:  011001

 Boron
   CAS No.  7440-42-8
   EPA Cheat Code:  128945

 BromacU
    CAS No.  314-40-9
    EPA Chen Code:  012301
Cannot be
determined,
but euggestlve
A (CRAVE)
                                0 (CRAVE)
                                D (CRAVE)
 82 (CRAVE)
Increase* In glandular stomach (forestoav
acti) tuaora in both aexs of nice and rats;
CD-I Nice 4 Sprague-OaMley rate
Increased Incidence of nonlymphoeytle
leukemia fro* occupational exposure; Human
Increated Incidence of neoplesia in rata t
•Ice axpoaad by inhalation t gavage.
                 Hemenoioperfeytomes In the urinary bladder
                 Hepatocellular carcinomas i combinded
                 hepatocellular adenomas I carcinomas;
                 SMlaa Uebeter nice (N)
 Increased evidence of hepatomas; (CS7B1/6
 x C3H/Anf)M mice (M t  F)  and (C57B1/6 x
 AKR)F1 Mica (N).
                               MCPRC  reccmnended  that for risk assessment
                               purposes, an MOE approach should be used
                               based  on the most  sensitive precursor stomach
                               lesion.
2.9 E-2 (0)
8.3 E-6 (I)
        This assessment is located on IRIS.
        not reviewed this chemical.
                                                                                                                                 OPP has
                                                                                                                     Oef.
 1.1 E+0 (0)
 3.3 E-4 (I)
                                                                                                                     82
                                                                                             Assessment based on  lack of data concerning
                                                                                             carcinogenicity  in huaans ( inadequate animal
                                                                                             data.   This assessment  is located on IRIS.
                                                                                             OPP has not reviewed this chemical.
        Assessment based on the tack data concerning
        carcinogenic!ty in hums a inadequate animal
        data.  This assessatent is located on  IRIS.
        OPP has not reviewed this chemical.

        This assessment is located on IRIS.   OPP has
        not reviewed this chemical.
        [Syn. Dlehloroethyl ether)
                  Liver tunors (carcinomas t combined
                  adenomas/carcinomas);  CD-I mice (*)•
                  Thyroid tuaora (C-cell adenomas I folllcu-
                  lar cell combined adenomas/carcinomas):
                  Crl:CO (BR) rats (H).

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DATE: 05/27/98
             OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                             PAGE:  5
           CHEMICAL
  CURRENT OPP
CLASSIFICATION
        TIMOR TYPE / SPECIES
 POTENCY
   VALUE
                                                                                                            SAP
                                                                                                           CLASS
CRAVE
CLASS
                                                                                            COMMENTS
BromotrlehloroaNthane
  CAS No.  75-62-7
  EPA Chw Cod*:  008708
Bromoxyni I
  CAS No.  1689-84-5
  EPA Che* Codt: 035301
 Bronuconaxole
   CAS No. 116255-48-2
   EPA Che* Code: 120503

 Bronopol
   CAS No. 52-51-7
   EPA Che* Codt: 216400

 Butylate (Sutan)
   CAS No. 2008-41-5
   EPA Chan Coda: MHOS

 CaeodyUc acid
   CAS No. 75-60-5
   EPA Chem Coda: 012501

 cadmium
   CAS No. 74*0-43-9
   EPA Che* Coda:
 caduaa/oa (Ebufas/Rugby)
   CAS No. 95465-99-9
   EPA Che* Cade:  128864

 Calcium cyanamide
   CAS No. 156-62-7
   EPA Che* Code:  014001
 Captafol
   CAS No.  2939-80-2
   EPA Chem Code: 081701
 Captan
    CAS No.  133-06-2
    EPA Chem Code:  081301
0 (CRAVE)
C(q)
B2
 B1  (CRAVE)
 1  (IMC)
 C(q)
 82
 2A (IARC)
                                 B2
Statistically tlgnificant increase* in
hepatoceUular adenoMs and/or carcinonaa
8 combined adenomas/carcinomas; CD-I  *ice
(Hi F)
Urinary bladder tumor; Fischer 344 rats
(N I F).  fibrosarcomae (Multiple organs);
B6C3F1 *ica (F).

limited evidence fro* occupational eptdaa-
iotooic studies.  Evidence of carcinogen-
Icity in rats « *ice by inhalation t
intramuscular ( subcutaneous injection.
Ovarian grenulosa-thece tumors; CRL:CO-1
(ICR)BR mice (F)  (Hydrogen cyanamide].
Positive trend in hemangiosarcomas; B6C3F1
mice (H) ICalcfum cyanamide]
Lymphosarcomas t hemangiosarcomas (H t F),
harderI an gland adenomas (H) CD-1 mice.
Nannary fibroadenoma (M t F), renal
adenomas/carcinomas (combined) (M)
Sprague-DBttley rats.

Renal cortical/tubular cell neoplasms;
CO  rats (»); Uterine sarcomas; Utstar rats
(F).  Intestinal tumors (H t F); B6C3F1,
ICR CD-I t CR CD-I mice.
                                                                          Assessment based on  tack of data concerning
                                                                          carcinogenicity in hunans or animals.
                                                                          This  assessment is located on IRIS. OPP has
                                                                          not reviewed this  chemical.
1.03 E-1
4.1 E-1
                                                              6.23 E-2
                                                              1.8 E-3 (I)
                                                                                    B1
                              This assessment is located on IRIS.
                              not reviewed this chemical.
                                                                                                                                OPP ha»
                                                              6.74 E-2
                                                                                             5.1 E-2
                                                                                             2.4 E-3
                              Calcium cyanamide is rapidly t quantitatively
                              converted to Hydrogen cyanamide in solution t
                              at the pH of the human t rodent gut.  Thus.
                              Calcium cyanamide studies were used as
                              supporting data for Hydrogen cyanamide.
                                                                                                           B2
                                                                                                                    Pend.

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DATE: 05/27/98
                                            OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                             PAGE:  6
           CHEMICAL
                                 CURRENT OPP
                               CLASSIFICATION
                                                        TUMOR TVPE / SPECIES
 POTENCY 4* I  SAP   I CRAVE
   VALUE      CUSS  I CLASS
                                                                                                                                              COMMENTS
Carbaryl
  CAS NO. 63-25-2
  EPA Chea Code: 056401
Carbon tetrachloride
  CAS No. 56-23-5
  EPA Che* Code: 016501

ChlorMtoen
  CAS No. 133-90-4
  EPA Chea Code: 029901
Chlordane
  CAS No. 57-74-9
  EPA Chea Code: 058201
 ChlordfMfor*
   CAS No. 6164-98-3
   EPA Chea Cod*: 059701
 Chlorfenapyr (Pirate)
   CAS No. 122453-70-0
   EPA Chea Code: 129093
 CttloroanUtne, p-
   CAS No. 106-47-8
   EPA Chea Code: 017203
 Chlorobenzene
   CAS No. 108-90-7
   EPA Che* Code: 056504
 Chlorobeniilate
   CAS No. 510-15-6
   EPA Chem Code: 028801

 Chlorofora
   CAS No. 97-66-3
   EPA Chen Code: 020701
                                C(tj)
                                K (CRAVE)
                                Deferred
82 (CRAVE)
2B (IARC)
B2
3 (IARC)
                               Cannot Be
                               Oeterained
                               Suggestive
                               B2
                               2B  (IARC)
                                0 (CRAVE)
                                B2 (CRAVE)
                                                Heaangfoaarcoaaa (Ml(grant vascular tut-
                                                ors) t coablned heaangloMs/heaangiosar-
                                                       CRL;CT-1 (ICR)BR Mice (N).
                                                Napatocellur carcinomas; Oaborne-Mendel,
                                                Japanese i Wlstar rats; 86C3F1. CJN,  A,  »,
                                                C and L mice; Syrian golden hauler*
                                                 Benign t malignant  liver tuaors; CS7B1/6N,
                                                 CD-I,  B6C3F1 A ICR  aiice (M I F); F344 rats
                                                 Malignant haaangtoendotheloaas; Tlf:MAG:
                                                 SPF  alee (M t F)
                                                 The overall evidence  In anlaala Has not
                                                 perauasuve. but could not be diMissed.
                                                 Increase  In tutors  In rats occurred Mfth
                                                 significant positive  trends only, and
                                                 aainly at the highest dose.

                                                 Spleen (f ibrosarcoaas, heaangiosarconas 1
                                                 osteossrcoaas) (M); Adrenal (pheochroaocy-
                                                 toaas) (MiF); F344/N  rats.  Hepatocellular
                                                 adenomas/carcinomas (M); Nenangiosarcoais
                                                 in spleen (/or Uver  (M); B6C3F1 alee
                                                Kidney tuaars; Osborne-Hendet rats (M).
                                                Hepatocellular carcinomas; B6C3F1 alee
                                                (H ft F); Hepatomas; A and NLC strain alee
                                                (F).
2.27 E-2
1.3 E-t (0)
1.5 E-5 (I)
                                                                                                                    B2
                                                                                             1.3 E+0 (0)
                                                                                             3.7 E-4 (I)
                                                                                             1.3  (diet)
                                                                                             9.4 E-1
                                                                                                                    B2
                                                                                             6.38 E-2
6.1 E-3
2.3 E-5
                                                                     (0)
                                                                     (I)
                                                                                                                    B2
                                                                                            Carbaryl also induced tinurs at multiple
                                                                                            organ sites in alee t rats but at dose level*
                                                                                            considered to be excessively toxic  for
                                                                                            carcinogen!city testing.
                                                                                            This assessment is located on IRIS.
                                                                                            not reviewed this cheaical.
                                     OPP has
                               HCPRC requested reviewer to re-tabulate data
                               for both  NCI  studies;  including data for
                               pooled controls £  results of the data audit;
                               historical  controls are also required. Rerev-
                               iew 1979  rat  study ft 1978 mouse study.

                               Chlordane is  structurally related to other
                               known liver carcinogens.
                               This assessment is located on IRIS.  OPP has
                               not reviewed  this  cheaical.

                               Timor was observed in 3 studies - Chlordiraef-
                               or* i its two aetabolites {N-formyl-4 chloro-
                               o-toluidine t 5-CAT].
                               0* of 9.4 E-1 is for occtaiational.
                                                                                                                           p-Chloroaniline is a aetabolite of DinMin.
                                                                                                                           Assessment  Is based on lack of hunan data.
                                                                                                                           inadequate  animal data t predominantly negat-
                                                                                                                           ive genetic toxicity data.  This assessment
                                                                                                                           is located  on IRIS.  OPP has not reviewed
                                                                                                                           this chemical.
This assessment is  located on IRIS.
not reviewed this chemical.
                                                                                                                                                               OPP has

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DATE: 05/27/98
             OFFICE OF PESTICIDE PROGRAMS LIST  OF  CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                             PAGE:  7
CHEMICAL
Chlorothalonil
CAS No. 1897-45-6
EPA Chm Cod*: 081901
CURRENT OPP
CLASSIFICATION
Likely
3 CIARC)
TUMOR TYPE / SPECIES
Renal adenomas i carcinomas, both tenet of
rats i ale*; rarity of the tuaor reipome
In the kidney; papl llamas I/or carcinomas
of the forestomech In rats t mice; CD-I
•fee; Ftachar 344 * Osborne-Mendel ratt
POTENCY B*
VALUE
7.7 E-3
SAP
CLASS
Defer.
CRAVE
CUSS
Pend.
COMHENTS
HCPRC recoanended that a non- linear appraoch
to ri«k assessment, using HOC. should be
uted.
Chlorpropha* (CIPC)
  CAS No.  101-21-3
  EPA Ch«« Code: 018301

Chlorpyrifos
  CAS No.  2921-88-2
  EPA Chwa Code: 059101

Cinch (C1 methyl In)
  CAS No.  B781B-31-3
  EPA Che* Code: 128837
 Clofenteiine >«- Code: 036501

 Creosote
   CAS No. 8001-58-9
   EPA Chea Code: 025004
 Cresol, p-Chloro-m-
   CAS No. 59-50-7
   EPA Chen Code: 064206

 Cryolite (Kryoclde)
   CAS No. 15096-52-3
   EPA Chem Code: 075101

 Cyanarine (Bladex)
   CAS No. 21725-46-2
   EPA Chen Code: 100101
                 Thryroid follicular cell adenoma/carcinoma
                 Sprague-Dawley rat YH).
D (CRAVE)
                                                                                            HCPRC concluded there was no sifcstantial bio-
                                                                                            logical  evidence of  tumor formation in mice
                                                                                            or rats, however, dosing in both studies were
                                                                                            inadequate for determining carcinogenic pot-
                                                                                            ential.   Additional  studies are requested.
                                                                           Assessment  based on tack of human data t
                                                                           inadequate  animal data  from assays of copper
                                                                           compounds.   This assessment is located on
                                                                           IRIS.   OPP  has  not  reviewed this chemical.
Bl (CRAVE)
Limited evidence of the association betwe-
en occupational creosote contact t subsqu-
ent tuaor formation, sufficient evidence
of local t distant tutor formation after
denttl application to nice.
                                                                                    Bl
This assessment is located on  IRIS.
not reviewed this chemical.
                                                                                                                                OPP ha.
C(q)
Mammary gland tuwrs (adenocarclnoma,
carctnosarcoBia); Sprague-DaNely rat 
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                                            Off ICE Of PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                              PAGE:  8
           CHEMICAL
  CURRENT OPf»
CLASSIFICATION
                                                        TUMOR TYPE / SPECIES
                                             POTENCY Q*
                                               VALUE
              SAP
             CLASS
CRAVE
CLASS
                                                                                                                                             COMMENTS
cycUnitfde
  CAS No.  11J136-77-9
  EPA Chen Coda:  026201

Cyhalothrln/Karate
  CAS No.  68085-65-8
  EPA Chen Code:  12886?
 Cypenwthrin
   CAS Ho. 52515-07-8
   EPA Chen Code: 109702

 Cyproconazole'(SAN 619F)
   CAS No. 9*361-06-5
   EPA Chen Code: 128993
 Cyronazlne (Larvadex)
   CAS Ho. 6621S-27-8
   EPA Chen Code:  121301

 ODD
   CAS No. 72-54-8
   EPA Chen Code:  029101
  ODE
    CAS No.  72-55-9
    EPA Chen Codet
  DDT
    CAS No. 50-29-3
    EPA Chen Code: 029201
  DEET
    CAS No. 134-62-3
    EPA Chen Code: 080301

  Dacthal (DCPA)
    CAS Ho. 1861-32-1
    EPA Chem Code: 078701
Not Likely
 •2
 B2 (CRAVE)
 28 (IARC)
 B2 (CRAVE)
 28 (IARC)
 B2 (CRAVE)
 2B (IARC)
  C(q>
Benign lung adenonn (increase in both
adenoiM ft adenonas/carcinonas combined);
Alderly Park SPF Suite strain Mice  (F)

Hepatocellular adenoMs t carcinoiaas; CO-1
•ice (H I f>.
                                                              3.02 E-1
Lung  tuaors (N ft F). liver tinori (M);
CF-1  «lc«.  Thyroid tunort (folltcular
cell  adenoma t carcinomas); Osborne-
Mendel raU (N).

Liver tumrs; B6CJF1 mice (hepatocellular
carcinoma) (H ft F); CF-1 nice (hepatons)
(N t  F).  Liver (neoplastice nodule*);
Syrian Co I dm Hamsters (M ft F).  Thyroid
tutors; Osborne-Nendel rats (F).

Tuaora (generally of the Uver) were obse-
rved  in 7 studies In various wouse strains
 [BALB/C, CF-1, A strain, Suiss/Boneby ft
(C57Bt)K(C3HxAkR)l ft^in 3 rat studies
(Ui»tar, HRC Porton * Osborne-Hendel).
 Thyroid tunors (N-ft F); Mepatocellular
 BdenomB/carclnoma/hepatocholoangiocarcin-
 oma 
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ATE: 05/27/98
             OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                             PACE:  9
          CHEMICAL
  CURRENT OPP
CLASSIFICATION
        TIMOR TYPE / SPECIES
 POTEHCT 0*
   VALUE
                                                                                                            SAP
                                                                                                           CLASS
CRAVE
CLASS
COMMENTS
amlnozlde (Alar)
 CAS No.  1596-84-5
 EPA Choi Code:  035101
 CAS No.  533-74-4
 EPA Chem Code: 035602
lesmedipham
  CAS No. 13684-56-5
  EPA Cheat Code: 104801

>i (2-ethylhenyl )phthalat«
  CAS No. 117-81-7
  EPA Chem-Code: 295200
tiazlnon
  CAS No. 333-41-5
  EPA Chan Code: 057801

Hbromochloropropane  (DBCP)
  CAS No. 96-12-8
  EPA Chem Code: 011301

>ibronoethane,  1,2-
  CAS No. 106-93-4
  EPA Chem Code: 042004
 libutyl phthalate
  CAS No.  84-74-2
  EPA Chem Code:  028001
 oicamba
   CAS No.  1918-00-9
   EPA Chen Code:  029801

 oiehlobentl
   CAS No.  1194-65-6
   EPA Chem Code:  027401

 lichlorobenzamide, 2,6-
   CAS No.  2008-88-4
   EPA Chen Code:  027402
B2  (CRAVE)
Not  Likely
 B2 (CAG)
 28 IIARC)
 B2 (CRAVE)
                               D  (CRAVE)
 Unclasstfiable
                 Multiple sites 
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             Oftlf£ OF PESTICIDE PROGRAMS LIST Of CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                              PAGE: 10
           CHEMICAL
  CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY Q*
  VALUE
 SAP
CLASS
CRAVE
CLASS
                                                                                                                                              COMMENTS
Olchlorobenient,  t.2-           0 (CRAVE)
  CAS  Ho.  95-50-1
  EPA  Cham Code:  059401
Dlchloroethane, 1,2-           §2 (CRAVE)
  CAS No. 107-06-2
  EPA Che* Code: 042003
 Olchloroethylene. 1.1-       I C (CRAVE)
   CAS No. 75-35-4            I
   EPA Che* Code: 600033      |

 Dfchloromethane                82 (CRAVE)
   CAS Mo. 75-09-2
   EPA Che» Code: 042004
 Dichloropropene.  1,3-          B2
   CAS No. 542-75-6
   EPA Che* Code:  029001
 Dlchlorvos  (DDVP)               «q)
   CAS No. 62-73-7               2B (1ARC)
   EPA ChM  Code: 084001
 0 I clof op-methyl  (Hoelon)       C(q)
   CAS No.  51338-27-3
   EPA Chen Code: 110902
  Dfcofot (Kelthane)           I C
    CAS No. 115-32-2             3 (IARC)
    EPA Ctie».Code: 010501      |

  Oieldrln                       "2 «**VE)
    CAS Ho. 60-57-1
    EPA Chen Code: 045001
  Dlethyl phthalate              0 (CRAVE)
    CAS No. 84-66-2
    EPA Chen Code: 128947
                 Induction of several tutor types in rate
                 0*borne-Mendel rats ft 86C3F1 Mice treated
                 by gavage and lung papflloens in 1CR/HA
                 Swiai Mice after topical application.

                 Kidney adenomacarcinoma; Swiss mice (M)
                 Hepatocellular neoplasms t alveolar/bron-
                 chi otar neoplasma; B6C3F1 mice (M ft F).
                 Benign mammary tumors (M & F), salivary
                 gland sarcomas (N). leukemia (F); F344
                 rat*.

                 Forestomaeh,  liver, mammary, thyroid.
                 adrenal, urinary t lung tumors; FUcher
                 344  rat* ft B6C3F1 mice (N ft F).
                 Bronchioloaveoler adenoM*; B6C3F1 eiice
                 (M).

                 Stonach tumor* (forestonach. papillona
                 squamous, t squammis cell carcinoma);
                 B6C3F1 Mice;  (F).  Leukemia (of all sites
                 ft types); Fischer 344 rata (M).

                 Significantly increased (palraise ft trend)
                 hepatocellular adenomas. carcinomas >
                 combined  tumors; HOE NMRKf (SPF 71) Mice
                  (N ft F).

                 Liver tvmora  (adeno«as/c.arcinom>; B6C3F1
                 •ice (M)
                  Effects range front benign Hver tunors  to
                  hepatocarcinomas with transplantation con-
                  firmation, to pulawnary netastases; M ft F
                  nice (C3HeB/Fe.  C3H.  CF1. B6C3F1. C3H/ME ft
                  C5TB1/6J)
                                     9.1 E-2 (0)
                                     2.6 E-5 (I)
                                     6.0 E-1 (0)
                                     5.0 E-S (I)
                                     7.5 E-3 (0)
                                     4.7 E-7 (I)
                                                                                              S.33E-2 (I)
                                                                                              1.22 E-1
                                                                                              2.3 E-1
                                                                                                                    B2
                                                                                     82
                                                                                                                     82
                                                                                                                     B2
                                      1.6 E*1 (0)
                                      4.6 E-3 (1)
                                                                                                                     Oef.
                                                                                     B2
                                                                                            Aaseasawnt based on lack of data concerning
                                                                                            carcinogenic!ty in tunans ft inadequate animal
                                                                                            data.   This assessment is located on IRIS.
                                                                                            OPP has not reviewed this cheaical.
                                                                                             (Syn. Orthodichiorobenzene]
                              This assesaaent  is  located on IRIS.
                              not reviewed this ehearicat.
                              (Syn. EDO
                                                                                                                                                                 OPP has
                              This assessment  is  located on IRIS.  OPP has
                              not reviewed this chemical.
                              [Syn. Vinylidene chloride)
                              This assessment  is located on IRIS.
                              not reviewed this chemical.
                                                                    [Syn.  Telon* II)
                                                                                                                             CRAVE 0* - 2.9 E-1 (0).
                                                                                                                                 OPP has
                              This assessment Is located on IRIS.
                              not reviewed, this chemical.
                                                                                                                                 OPP has
                                                                                             Assessment based on  lack of data concerning
                                                                                             carcinogenicity in huaans or »n'"»ls-
                                                                                             This assessment is located on IRIS.  OPP has
                                                                                             not reviewed this chemical.

-------
)AlEt  05/27/98
                                            OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                             PAGE:  11
           CHEMICAL
  CURRENT OPP
CLASSIFICATION
                                                        TUMOR TYPE / SPECIES
                                            POTENCY 0*
                                              VALUE
 SAP
CLASS
CRAVE
CLASS
                                                                                                                                            COMMENTS
Hfenoconazole (Oividtnd)
  CAS Ho. 119446-68-3
  EPA Chem Code: 1288*7

Hfenzoquat methyl aulfat*
  CAS No. 43222-48-6
  EPA ChM Code: 106401

Hflubenturon (Dimllln)
  CAS Ho. 35367-38-5
  EPA Che* Code: 108201

Hmethenanid (SAN  5B2H)
  CAS He. 87674-68-8
  EPA ChM Code: 129051
 >iMthipin (Harvade)
   CAS No.  55290-64-7
   EPA Chem Code: 118901

 )imethoate
   CAS No.  60-51-5
   EPA Chen Code: 035001
 31methyl ether
   CAS No.
   EPA Chen Code:
 Jimethyl phthaUte
   CAS No. 131-11-3
   EPA Chew Code: 028002
 Jinocap (Kara thane)
   CAS No. 39300-45-3
   EPA Cheat Code: 036001

 Dinoseto
   CAS No. 88-85-7
   EPA Chen Code: 037505

 aiphenylamine
   CAS No. 122-39-4
   EPA Chen Code: 038501
                                D (CRAVE)
 Not Likely
                 Statlatically aignlftcant Increases in
                 liver adenoMS, carcinomas t combined
                 adenomas/carcinomas; CD-I mica (N I F).
                 Statlatically significant increasing trend
                 for benign combined */or malignant liver
                 tuaora; Sprague-Oanley rat (M).  Unresolv-
                 ed Usuas regarding nasal tuaors. strong
                 autagenicity data A SAR.

 Tentative C     I Lung  adenoMa I carcinoMs; CD-I mice (N)
                  Hemolymphoretlcular  tuaora; B6C3F1 mice
                  .  Spleen (heaMngieaia t he*angiosarcoM>
                  akin  (heawgloaarcoM), ly^ (anglona I
                  angiosafcoav)  tuaora; Uiatar rats (N).
                  Liver adenoma; CO-1 mice (F).
Classification supported by animal metabo-
lism studies and open literature data that
indicate there was no evidence that the N-
nitroso metabolite of diphenylamlne would
be formed in rat or hunans in vivo.
                                                                         Tuaora were observed at doses whfch were
                                                                         considered to be excessively high  for carcin-
                                                                         ogen! city testing.
                                                                                            p-Chloroaniline is  a metabolite.
                                                                          HCPftC  recommended a heritable translation
                                                                          test,  which  is  the nent required test  after a
                                                                          positive dominant lethal study 
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DATE: 05/27/98
             OFFICE Of PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                             PACE: 12
           CHEMICAL
  CURRENT OPP
CLASSIFICATION
        TIMOR TYPE  / SPECIES
 POTENCY 0* |   SAP   I CRAVE
   VALUE    I  CLASS   CLASS
                                                                                                                                              COMMENTS
Diquat dibromtde
  CAS No.  85-00-7
  EPA Chem Code: 032201

DUutfoton (Disyston)
  CAS No.  298-04-4
  EPA Chen Code: 032501

Dlthiopyr  (MON 7200)
  CAS No.  97886-45-8
  EPA Chem Code: 128994

Dfuron
  CAS No.  330-54-1
  EPA Chem Code: 035SOS
 Endosulfan
   CAS No. 115-29-7
   EPA Chen Code: 079401

 Endrln
   CAS Ho. 72-20-8
   EPA Chew Code: 041601

 Epichlorohydrln
   CAS No. 106-89-8
   EPA Chen Code: 097201
 Esfenvalerate  (Asna)
   CAS No. 66230-04-4
   EPA Che*  Code:  109303

 Ethalfluralin  (Sonalan)
   CAS No. 55283-68-6
   EPA Chen  Code:  113101

 Ethephoo
   CAS No. 16672-87-0
   EPA Chem  Code:  099801
  Cthion
    CAS No. 563-12-2
    EPA Chem Code: 058401
Known/Likely
 D (CRAVE)
 82 (CRAVE)
 C(q)
                                                                                                                    Pend.
Urinary bladder carcinomas; Uistar rat  (M
1 ft. Mammary gland carcinomas; NMRI  mice
(F). Information fron structurally related
analogs provided further support.
An NCI bioassay Mas suggestive of response
in Osborne-Nendal rats (M i F).
Multiple studies in rats t nice administ-
ered eplchlorohydrln by various routes
were positive.  As epichlorotiydrin Is a
strong alkylating agent, tumors are prod-
uced at the site of application.
Mammry tuaors (F); Suggestion of bladder
tutors (F) and kidney tumors (f t F);
Fischer 344 rats
                                                                                                                    Def.
9.9 E-3 (0)
1.2 E-6 (1)
                                                              8.9 E-2
                               For  the purpose of risk characterization, a
                               low  dose linear extrapolation model  be appl-
                               ied  to the animal data for the quantification
                               of human risk, based on urinary bladder car-
                               cinomas in the male rat.
                               This assessment is located on IRIS.   OPP has
                               not reviewed this chemical.
This assessment is located on IRIS.  OPP has
not reviewed this chemical.
                                                                                            Data from Fenvalerate (CAS No.
                                                                                            was used In this assessment.
                                                                                                                                                          51630-58-1)
                              HCPRC considered the dose levels in the mouse
                              study to be Inadequate; however HCPRC did
                              not recommend repeating the study.

                              The RFOC considered that the evidence from
                              the 2 rat studies t 1 of the mouse  studies to
                              be inadequate to support a positive carcino-
                              gentctty finding, while the evidence from the
                              other mouse study was equivocal.

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DATE: 05/27/98
                                            OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                            PAGE: 13
           CHEMICAL
                                 CURRENT OPP
                               CLASSIFICATION
        TIMOR TYPE / SPECIES
 POTENCY Q* I  SAP    I CRAVE
   VALUE      CLASS   I CLASS
                                                                                            COMMENTS
EtMoxtn  (Ebuzin/Tycor)       | Tentative C
  CAS No. 64529-56-2
  EPA ChM Code:  128883

Ethofenprox  (Etofenprox)      I C(q)
  CAS Ho. 80844-07-t          I
  EPA Che* Code:  128965
Ethofumesate
  CAS  No.  26225-79-6
  EPA  Che* Code:  110601
 Ethoprop (Ethoprophoe)         Likely
   CAS No.  13194-48-4
   EPA Chew Code:  041101
 Ethylene                     I  3 (IARC)
   CAS No.  74-85-1
   EPA Che* Code: 041901      |

 Ethylene diemine               0 (CRAVE)
   CAS No.  107-15-3
   EPA Che* Code: 004205
 Ethylene dibromtde (EDI)       B2 CCAG]
   CAS No. 106-93-4             2A (IARC)
   EPA Che* Code: 042002
 Ethylene oxide               I t (IARC)
   CAS No. 75-21-8            I
   EPA Che* Code: 042301      |

 Ethylene thiourea (ETU)        82
   CAS No. 96-45-7
   EPA Chen Code: 600016
 Fenaniphos (Neaueur)
   CAS No. 22224-92-6
   EPA Chew Code: 100601

 Fenarinol
   CAS No. 60168-88-9
   EPA Chen Code: 206600
Thyroid follicular cell tuners;  F344 rate
(N ft F>
Combined thyroid follicular cell  adenoma*/  I 5.1 E-3
carcinomas; Sprague-Dawley rata (N A F).    I
Pheochromocytoma - .adrenal glands (aallgn-
nant); .Sprague-Dawley rat (H>; Cell  carc-
inoma* - thyroid gland; Sprague-OaMley t
Fiecher 344 rat (M); Evidence of clasto-
genlclty in vitro tutagenicity testing
Foreatomach (aquamoua cell carcinomas)
(N * F) Otbome-Mendet rata t B6C3F1 Mice.
Alveplar/bronchiolar adenoma (HtF) nice.
Kemengtosarcomas (circulatory ayate*) ft
hepatocellutar carcinoma* (N) rata.
Thyroid adeneaw, carcinoma, ft coabined
adenoM/carclnoM; F344 ft CRCO rata (NtF).
Thyroid ademxaaa ft carcinona, putultary t
liver tuaore; B6C3F1 t C57BL/6 x AKR nice
(N ft F).
                                                                                             2.81 E-2
67
1.4
(0)
(»
                                             6.0 E-2
                                                          B2
                                                                   Pent).
                              Quantification deferred pending submission t
                              evaluation of additional data.
                              Assessment based on the fact  that the carcin-
                              ogen! city phase of the rat  study t the
                              heanter study were both considered to be
                              inadequate.

                              A linear low-dose approach  for hunan risk
                              characterization t extrapolation should be
                              baaed on malignant pheoehromocytoims of the
                              adrenal glands in male rats at all dose
                              levela tested.
                                                                           Assessment  based on  Uck of data concerning
                                                                           carcinogenic)ty in humans or animals.
                                                                           This assessment is located on IRIS. OPP has
                                                                           not  reviewed this chemical.

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DATE: OS/27/98
             OFFICE OF PESTICIDE PROGRAMS LIST Of CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                            PACE:  H
           CHEHICAL
  CURRENT OPP
CLASSIFICATION
                                                        TIMOR TYPE / SPECIES
                                             POTENCY a*
                                               VALUE
 SAP
CLASS
CRAVE
CLASS
                                                                                                                                            COMMENTS
Fenbuconaxol* (Fwwttimll)
  CAS Ho.  114369-43-6
  EPA Choi Code:  129011
 Fenbutatln oxide (Vendex)
   CAS No.  13356-08-6
   EPA Che* Code: 104601

 Fenftrothion ; CO-1 aiice
                                                                                             1.06 E-2
 B2
Lung adenoMS, carcinomas ft combined
adenow/carclnona; Harder I an 4! and
adenoMt; CD-I «ice 
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DATE: OS/27/98
             OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS  EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                           PAGE: IS
            CHEMICAL
  CURRENT OPP
CLASSIFICATION
       TUMOR TYPE / SPECIES
                                            POTENCY Q* I  SAP   I CRAVE
                                              VALUE    I CLASS  I CUSS
                                                                                                                                             COMMENTS
FluaJelorac pent yI
  CAS No.  875*6-18-7
  EPA Chem Code:  128724

Fluometuron
  CAS No.  2164-17-2
  EPA Chen Code:  035503
 Fluridone
   CAS No. 59756-60-4
   EPA Che* Code: 112900

 Fluroxvpyr (DOUCO 433)
   CAS No. 69377-81-7
   EPA Chem Code:

 Flusiluol* (Hustar)
   CAS No. 85509-19-9
   EPA Che* Code: 128835

 Mutolanil (Honcut)
   CAS No. 66332-96-5
   EPA Che* Code: 128975

 Folpet
   CAS No. 133-07-3
   EPA Chew Code: 081601

 fomesafen (Flex)
   CAS No. 72128-02-0
   EPA Che* Code: 123802

 Fonofos (Dyfonate)
   CAS No. 944-22-9
   EPA Che* Code: 041701

 formaldehyde
   CAS Ho. 50-00-0
   EPA Chew Code: 043001
  Formetanate hydrochlorlde
    CAS No. 23422-53-9
    EPA Chem Code: 097301

  Fosetyl-At (Allette)
    CAS No. 39148-24-8
    EPA Chem Code: 123301
Not Likely
Deferred
 •2
 C(q)
 81 (CRAVE)
 Unclassified
                 Statistically significant increases in
                 combined adenomas/carcinomas of the lung
                 
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JATE: OS/27/98
                                            Off ICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                             PAGE:  16
CHEMICAL
.CURRENT OPP
CLASSIFICATION
TUMOR TYPE /
SPECIES
POTENCt 0*
VALUE
SAP ' 1
CLASS -
CRAVE I
CLASS I
COMMENTS
FunMcycloM  (Xylloen I)       I BZ
  CAS No. 60568-05-0
  EPA Che* Code:  122601       |

Glyphosate                    I E
  CAS No. 1071-83-6     .     I
  EPA Cheat Code:  417300       |

Glyphosate tr.imesiua         IE
  CAS Ho. 51591-81-3
  EPA Chen Code:  128501       |

Halosulfuron-methyl          I E
  CAS No.  100784-20-1
  EPA Che» Code:  128721       |

Haloxyfop-methyl  (Verdict)    B2
  CAS No. 690806-40-2
  EPA Cheat Code:  12S20I
 Heptachlor     -              I e2 (C**WE)
   CAS No. 76-44-8
   EPA Che* Code: 044801      |

 Heptachlor epcxlde  .   '      I B2 (CRAVE)
   CAS No. 1024-57-3
   EPA Che* Code: 044801      |

 Hexachlorobenzena (HCB)      I B2 (CRAVE)
   CAS No. 118-74-1           I 28 (IARC)
   EPA Che* Coder 061001

 Hexachlorocyclohaxane          B2 (CRAVE)
   CAS No. 608-73-1
   EPA Chen Code: 008901
  Hexaehlorocyclopentadierie,   '  ft (CRAVE)
    CAS No.  77-47-4
    EPA Chen Code: 027502


  Hexachloroethane              C (CRAVE)
    CAS No.  67-72-1
    EPA Chem Code: 045201

  Hexaconaiole (Anvil)           «q)
    CAS No. 79983-71-4
    EPA Chem Code: 128925
Liver tutor* (M ft F);  Urothellal  tuaora
(M); Sprague-Oawley rats
                                                                                             2.98 E-2
                                                                    B2
Liver tumors (adenomas (M). carcinomas (F)
ft adenomas/carcinomas (N ft F)l; B6C3F1
srfce.
                                             7.39 E-0
              Int. C
                                                                    Pend.
Benign and amlignant -H«r tuwors (M * F)  I 4.5 E+0 (0) j         I B2
in Bice (CM ft B6C3F.1)                       1-» *'* <»>


Liver earelnoa«»; C3H ft CO-1 «1e« (M ft F); I 9.1 E*0 (0) I         I
CFN  rata (F).                                2.6 E-3 (I)
 Tuaora  In  the  liver, thyroid t ki*ey «"   M-f f*» <°>
 rata (Sprague-OaWley. Aflus * Mlatar). alee   4.6 E-4 (I)
 (SNlaa  I ICR)  and haoatera (Syrian. Golden) |
 Benign hepatic nodules» hepatocellular
 carclnoaaa; Swiaa «fce (M).  Liver nodule*
 hepatoma; dd a>ic«  (N * F).  Hepatomaa;
 ICR-JCL  «lc«  (M ft F).
 Hepatoeellular carcinoma;  B6C3F1 wlce
 (Mi F).


 Benign Leydig cell  timers; Uiatar  (Alpk:
 APfSO) rat (M)
1.8 E+0 (0)
5.1 E-4 (I)
                                                                    B2
                                                                    62
1.4 E-2 (0)
4.0 E-6 (I)
2.3 E-2
                              CRAVE 0* -3.0 E-2 (0).
                                                                            [Syn. Sulfosate)
Aaaeasecht also based upon the acknouledge-
aent by the registrant.that the compoond
would be likely to cause tunors of  the  liver
In rata If tested at adequate dosage  levels.

This assessment is located on IRIS.   OPP has
not.reviewed this chemical.
                               Hexachtorobenzene is a contaminate of PCNB C
                               Dacthal.  OPP has revised (06/21/95) the oral
                               Q*  for HCB: 1.02 E+0.
This assessment is located on IRIS.
not reviewed this chemical.
Cfiyn. t-HCjtJ
                                                                                                                OPP has
                                                                            Assessnent  based on  inadequate data in htmans
                                                                            t no data In animals concerning earcinogenic-
                                                                            ity.  This  assessment  ia  located on IRIS. OPP
                                                                            has not  reviewed this  chemical.
This assessment is located on IRIS.
not reviewed this chemical.
                                                                                                                OPP has
Chemical was not adequately tested for
carcinogenic potential in mice. Repeat of
study not required at this tine.

-------
DATE: OS/27/98
                                             OFFICE OF PESTICIDE PROGRAMS  LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                             PAGE: 17
           CHEMICAL
  (CURRENT OPP
CLASSIFICATION
                                                         TUMOR  TYPE  /  SPECIES
                                             POTENCY Q*
                                               VALUE
SAP
                                                                                                                    CRAVE
                                                                                                           CLASS    CLASS
                                                                                                                                             COMMENTS
Hexsxlnone
  CAS No. 51235-04"-2
  EPA Che* Code:  107201
Hexythiazox  (Savey)
  CAS No. 78587-05-0
  EPA Chan Code:  128849

Hydra** thyInon (Amdro)
  CAS No. 67485-29-4 *
  EPA Chen Code:  118401

Hydrogen cyanamide
  CAS No. 420-04-2
  EPA Chen Code:  014002
 Kydroprene (Altoiar)
   CAS No.  41096-46-2
   EPA Chen Code:  486300

 Hydroquinone
   CAS No.  125-31-9
   EPA Che* Code:

 Inazalll
   CAS No.  35554-44-0
   EPA Chen Code:  111901
 Imazapyr (Arsenal)
   CAS No. 81334-34-1
   EPA Che* Code: 128821

 Imazethabenz (Assert)
   CAS No. 81405-85-8
   EPA Chen Code: 128843

 Imldacloprid
   GAS No. 105827-78-9
   EPA Chew Code: 129099

 Iprodiore (Glyeophene)
   CAS No. 36734-19-7
   EPA Chew Code: 109801
C(q)
C(q)
Not classified
C(q)
 Likely
                 Statistically significant increasing trend
                 In combined hepetocellular adenoma/careIri-
                 OM; CO-1 nice (F)
Liver (hspatocellular carcinomas t
carcinomas/adenomas combined); B6C3F1  mice
                 Lung adenomas ft combined adenomas/care fno-
                       CO-1 ale* (F).
                                                              2.22 E-2
        Pend.
Ovarian granulosa-theca tumors; CRL:CD-1
(ICt)IR •<» (F) (Hydrogen cyanamidel.
Positive trend in hemangiosarcomas; B6C3F1
Mice (M) [Calciuacyana«ide].
                                                              6.74 E-2
Hepatocellular adenonas t coofcinedadenom-
as/carclnosMS u/positlve trends for adeno-
M*. carcfnoMS & cosfatned adenomas/carc-
innaas (M); Liver tours (adenomas i cew-
bined adenoMS/earclnoams) (F>; Suiss site*
                 Vascular; Positive trend for henangiosar-
                 comas  in CD-I Mice (M).
                                                              5.6 E-2
                                                              6.2 E-2
                                                                                    Def.
Liver adenomas, carcinomas t confcined
adenomas I/or carcinomas (M t F); Ovarian
luteomas (F); Crl:CO-1 mice.  Testlcular
interstitial cell benign tumors;
Crl:CO(SQ)BR rats (M).
                                                              4.39 E-2.
                                                                           AssessMent based on evidence  that u»s equivo-
                                                                           cal  (not entirely negative, but yet not con-
                                                                           vincing) since only statistically significant
                                                                           increase MSB in  F nice (by trend test, but
                                                                           not  by pairuUe  coaparlson with controls).
                Calciua cyanamide is rapidly t quantitatively
                converted to Hydrogen cyanamide in solution t
                at  the pH of the hunan t rat gut.  Thus,
                Calciua cyanamide studies were used as
                supporting data for Hydrogen cyanamide.

                Assessment based on equivocal nature of the
                findings In the rat study and the lack of a
                carcinogenicity study in a second specie*.

                Hydroquinone .is a plant metabolite of Asulam
                HCPRC concluded that another rat study
                conducted at adequately high doses,  an in
                vivo  UOS study and an S-Phase cell prolifer-
                ation assay.

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DATE: 05/27/98
                                             OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOX CARCINOGENIC POTENTIAL
                                                                                                                                                 PAGE:  18
           CHEMICAL
                   '  CURRENT OPP
                   CLASSIFICATION
                                                         TUMOR TYPE  / SPECIES
                                                               POTENCY 0*  I  SAP
                                                                 VALUE     I CLASS
CRAVE
CLASS
                                                                                                                                              COMMENTS
 laophorone -
  CAS No.  78-59-1
  EPA Che* Cod*: 047401

 lioxaben IEL-107)
  CAS No.  82558-50-7
  EPA Che* Code: 125851

 Isoxaflutole
  CAS No. 14112-29-0
  EPA Chea Code: 123000
 Kathon 886 (Kathon Biocide)
   CAS No. 55965-84-9
   EPA Chen Code: 107106

 Lactofeh (Cobra).
   CAS Ho. 77501-63-4
   EPA Chen Code: 128888
 Llndane
   CAS NO. 58-89-9
   EPA Chea Code: 009001

 Llnuron
   CAS No. 330-55-2
 -  EPA Che* Code: 035506
 NBC
    CAS No.
    EPA Chen
Code:
  HOC Repellent 326
    CAS No. 136-45-8
    EPA Chen Code: 047201
  MGK-264
    CAS NO. 113-48-4
    EPA Chen Code: 057001
                                 C(q)
                                 B2
C (CRAVE)      | Preputtal gland carcinomas;-F344/N rate
                 (M).
                                    Nepatocetluiar adenoMs; B6C3M nice (HAF)
Likely           Statistically significant increases in
                 liver tumor* In both sexes of mice A rata;
                 statistically significant increases in
                 thyroid tumors In Ml* rats; CD-I nice A
                 Sprague-OaMley rata
B2              Nepatocelluar carcinomas (N); Hepatocell-
                 uar adenomas A carcinomas (N A F); CD-I
                 •Ice.  Liver neoplastlc nodules; Sprague-
                 Dawely rata (N A F),

B2/C (CAG)      I Liver and lung tumors (both gehlgn); nice
                                     Testfcular tumors; CD rats (N); Hepatocel-
                                     luar adenonas; CD-I nice 
                                     Statistically significant increases for
                                     thyroid folllcular cell  adenomas; Crl:CDBR
                                     rats (M).
                                                                                                       Pend.
                                                                                 1.7E-1
                                                                                              4.2 E-3
                                                              2.4 £-3 (M)
                                                              1.2 E-3 (F)
                                                                                                               This assessment is located on IRIS.   OPP has
                                                                                                               not reviewed this chemical.
                                                                                                               For the purpose of risk characterization,  a
                                                                                                               non-linear approach.- HOE be applied to the
                                                                                                               east sensitive precursor lesion in M rat thy-
                                                                                                               roid, C that a linear low-dose extrapolation
                                                                                                               be applied for the tumors of the rat liver.

                                                                                                               Assessment based on the lack of second car-
                                                                                                               clnogeniclty study in a another species.
                                                                                                               A Llndane metabolite, 2,4,6-trichlorophenol
                                                                                                               (TCP)  is classified as B2.
                                                                                            Benomyl rapidly hydrolyses to HSC in an
                                                                                            aqueous environment.  MBC also appears to be
                                                                                            the  Initial metabolite in manmalian systems.
                                                                                            MBC has similar or increased toxicity, both
                                                                                            acute t chronic, .to Bencmyl.

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DATE: 05/27/98
             OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                             PAGE: 19
           CHEMICAL
 IfURRENT OPf
CLASSIFICATION
        .TUMOR TWE / SPECIES
                        POTENCY 0*
                          VALUE
 SAP
CLASS
CRAVE
CLASS
                                                                                                                                             COMMENTS
MOH 21200 (Genesis)
  CAS No. 02697-71-0
  EPA ChM Cod*:  128726

Halethion
  CAS No. 121-75-5
  EPA ChM Code:  057701

Maletc  hydratide
  CAS No. 5716-15-4
  EPA Che* Code:  051502

Maneozeb
  CAS No. 8018-01-7
  EPA ChM Code:  014504
.Maneb
   CAS No. 12427-58-2
   EPA ChM Code: 014505
 MelMtne
   CAS No. 108-78-1
   EPA ChM Code:
 Hepfquat chloride
   CAS No. 24307-26-4
   EPAThM Code: 109101

 MereeptobenzotMazole, 2-
   CAS Mo. 149-30-4
   EPA ChM Code: 051701
  Mercury (Inorganic)
    CAS No.  7439-97-6
    EPA ChM Code:  052301
  Metalanyl
    CAS No. 57837-19-1
    EPA ChM Code: 113501

  Hetan sodlun
    CAS No. 137-42-8
    EPA ChM Code: 039003
D
3 (IARC)
B2
                                BZ
                                N/A
                                0  (CRAVE)
 B2
                 Statistically significant Increase in
                 histlocytfc sarcMSS (F); CD-I atce
Thyroid C-Call
i; F344 rat (N * F).
Thyroid foilIcular cell adenoaws t earcin-
paaa. cMbtned thyroid folticular cell
•denoMS I/or carcinoMs; Crl:CO(BR) rats

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DATS: 05/27/98
                                             OFFICE OF  PESTICIDE PROGRAMS LIST Of  CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                              PAGE: 20
           CHEMICAL
1  CURRENT OPP
CLASSIFICATION
                                                         TUMOR  TYPE / SPECIES
POTENCY a* |  SAP   I CRAVE
  VALUE    I CLASS    CLASS
                                                                                                                                              COMMENTS
Methemidopho* (Monitor)
  CAS No.  10265-92-6
  EPA Che» Cod*: 101201

Methane •r.onlc Kid CNAA)
  CAS No.  124-58-3
  EPA ChM Code: 128876

Methidathlon
  CAS No.  950-37-8
  EPA Chen Code: 100301

Methlocarb (Mesurol)
  CAS No.  2032-65-7
  EPA Che* Code: 100501
 Methomyl                       ««
   CAS No. 16752-77-5         I
   EPA Ch«M Code: 090301      |
 Methoxychlor                   0 (CRAVE)
   CAS No. 72-0-5              3 (IARC)
   EPA Che* Code: 034001
 Methyl bromide                0  (CRAVE)
   CAS No.  74-83-9
   EPA Ch«i Code:  053201
 Methyl  ethyl  ketone (MEK)      0 (CRAVE)
    CAS No.  78-93-3
    EPA Che* Code:  044103
  Me thy I en* bU(thlocyanate)
    CAS No. 6317-18-6
    EPA Chn code: 068102
  Methylphenol, 3-             !.« (CRAVE)
    CAS NO. 108-39-4
    EPA Ches Code: 022102      |
  Hetolachlor
    CAS Mo. 51218-45-2
    EPA Chen Code: 108801
                                                              1.38 E-1
                 LI var tumors (benign and malignant); CD-I
                 •Ice (M).
                  Benign adrenal  pheochromocytomas in N I
                  pituitary adenomas in F; Sprague-Dawl ey
                  rat«.  Alveolar/bronchial adenomas t car-
                  cinomas; CQ-1 nice (M*F). (All  lesions
                  were within >fstor leal control  range).

                  Increased incidence of skin papillomas in
                  •ice In ah Initiation-promotion study.


                  Liver adenomas  and contained adenomas/
                  carcinomas; Charles River CD(SD)BR rats
                  (F). (Sane liver neoplasia in female rats
                  was also observed In a separate repeat
                  study)  •
                              Data not reviewed by OPP.
                                                                                             Assessment based on .the lack of a second car-
                                                                                             et noflenic I ty study in another species.
                              Assessment based on lack of-daia concerning
                              carcinogenicity in huaans < inconclusive data
                              in animals.  This assessment  is  located on
                              IRIS.  OPP has not reviewed this chemical.

                              Assessment based on lack of data concerning
                              carcinogenicity in humans t inadequate animal
                              data.  This assessment is located on IRIS.
                              OPP has not reviewed this chemical.
                              CSyn. Bromomethane)

                              Assessment based on lack of data concerning
                              carcinogenicity in humans or  animals.
                              This assessment is located on IRIS.  OPP has
                              not reviewed this chemical.

                              RFDC based classification on inadequacy of
                              the data set and on what was  considered to be
                              a border line significance of the tumors
                              observed in rats and mice.


                              This assessment is located on IRIS.  OPP has
                              not reviewed this chemical.
                              ISyn. metaJCresdll

                              HCPRC reccmuended that a Margin  of Exposure
                              (HOE) methodology be used for the estimation
                              of human risk.

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DATE: 05/27/98
                                             OFFICE Of PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                             PAGE:  21
CHEMICAL
Metrtbusin 
CAS No. 21087-64-9
EPA Che* Code: 101101
CURRENT OPP
1 CLASSIFICATION
D
TUMOR TYPE / SPECIES
Pituitary adenomas; SPF Ulster rats (F)
POTENCT Q*
VALUE
'
SAP
CLASS

CRAVE
CUSS
l>
COMMENTS
Nates: 1993 rat study in Fischer COf(f-JU)/
8R rat* was negative. Chenical structurally
related to Ethiozln, which was associated
it/thyroid cell adenoma I combined adenomas/
carcinomas in Fischer 34* rats 
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>ATE: 05/27/98
                                           OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                             PAGE: 22
           CHEMICAL
                               VCURRENT  OPP
                              CLASSIFICATION
        TUMOR TYPE / SPECIES
                                             POTENCY 0*  I  SAP
                                               VALUE     I CLASS
                                                                                                                   CRAVE
                                                                                                                   CUSS
                                                                                             COMMENTS
torfluraun
  CAS Ho. 27314-13-2
  EPA Chea Code: 105801

irthopheny(phenol t Ha salt
  CAS Ho. 90-43-7
  EPA Cheej Code: 064103
iryialtn
  CAS No. 19044-88-3
  EPA Chen Code: 104201

ixadlazon
  CAS No. 19666-30-9
  EPA Che» Code: 109001.

taadixyl aclobutrazol
   CAS No. 76738-62-0
   EPA Che. Code: 125601
•aradlchlorobenzene
  CAS No:  106-46-7
  EPA Chen Code: 061501
                              $2
                              21 (IARC)
                              C(q)



                              Cleft



                              C(q>



                              Not Likely



                              C(q)
                              •2
                                               Liver adenoma ft combined liver adenonae *
                                               carcinows; CD-I ate*  (N).
Multiple tueor type* in Multiple studies.
Malignant urinary bladder ft kidney tunor*
(M); Papllloaes of the urinary bladder ft
uterine endoeetrlue (F); F344/DuCrj t F344
rats

Multiple sites (thyroid, nonary); F344
rats (N ft F).         -
Hepatocellular adenoma* (by pair-wise
comparison ft with a dose-related trend);
Nan-Mi»tar rats (M ft F).
Liver (adenomas,  carcinomas ft combined
adenomas ft/or carcinomas); CD-I  mice (N).
Lung tueors; NMRI Wee (M).
Kepatocellular tumors (M ft F) ft rare kid-
ney tuaors ; F344 rats.
Data shotting chesiical has clastogenic
activity provided additional support.

Benign stroul polpys (F); Leydlg cell
tunors (M); Sprague-Dauley Crl:CO(SO)BR •
rats.
                                                 Liver (adenomas and carcinomas); B6C3F1
                                                 •lce(NftF).
                                                                                             1.3 E-1
liver tuaors (Malignant, combined          I  1.4  E-1
malignant t benign); CR CD-I mica 
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DATE: OS/27/98"
             OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                            PAGE: Z3
           CHEMICAL
 .'CURRENT OPP
CLASSIFICATION
        TUMOR TYPE / SPECIES
POTENCY 0* I  SAP   I CRAVE
  VALUE  .   CLASS  I CLASS
                                                                                                                                             COMMENTS
Parenttrophenol
  CAS No. 100-02-7
  EPA Choi Code: 056301

Paraquat dfchloride
  CAS No. 1910-42-5
  EPA Cheai Code: 061601
Parathlon (Ethyl parathlon)
  CAS No. 56-38-2
  EPA Che* Code: 057501
PendinethalIn
  CAS Ho. 40487-42-1
  EPA Che*  Code:  108501

Pentach t oronlt robeiene
  CAS No. 82-68-8
  EPA Che*  Code:  056502

Pentachlorophenol
  CAS No. 87-86-5
  EPA Che*  Code:  063001
 Perec thrln
   CAS  No.  52645-53-1
   EPA  Che* Code:  109701

 PhenaedfphM (Bet ana I)
   CAS  No.  11684-63-4
   EPA  Chen Code:  098701

 Phenol
   CAS  No.  108-95-2
   EPA  Che* Code:  064001
 Phorate (Thimet)
   CAS No. 298-02-2
   EPA Che* Code: 057201
 Phosaet (laidan)
   CAS No. 732-11-6
   EPA Cheai Code: 059201
C
3 (IARC)
62
3 (IARC)
C(q)
3 (IARC)
Adrenal cortical tuaor* (adenoata* +
carcinomas; Thyroid follicular cell
•denoBB* * pancreatic call carclnoam;
Otborne-Mendel rat (M); Benign pancreatic
tuKtrs; Uistar rat (M)
                 Thyroid folUeular cell
                 Oewley rata (Hi F)
                        adenoMt; Sprague-
Thyroid follicular cell adenoMS (fay both
pair-Miae t trend analyst*) in Mies with
a poaitiva trend In feaales; CO rat*.

Hepatocellular adehoaia* t earcinoMS, adr-
enal awdulla pheochronocytoM* t Malignant
pheoctiroanc'ytomas, */or heaMngiesarcaena t
heaanaloam in one or both aexa of B6C3F1
•ice.          •                          ;

Lung (adenoMS 1 coablned •denomt/carcln-
OM); Liver (adenoM); CO-1 aiice (F).
                                                              1.29 E-1
                                                                                             1.84  E-2
             B2
0  (CRAVE)
                                Tentative C
                 Liver tuaors (adenomas C adenoma* +
                 carcinomas conb(ned) (M); Trend for liver
                 liver adenoma t carcinoma (F); 86C3F1 nice
                             Classification based on Inadequacy of the
                             data base,  i.e. lack of carcinogeniclty data
                             In a second eni*al species.

                             OPP t6 reevaluate uhen new data on powdered
                             diet are aubaritted.  SAP concerned with nasal
                             iquaiaom cell carcinoaa seen in Fischer 344
                             rata (M).                  l

                             Mouse carcinogenicity study should be
                             repeated but not using B6C3F1'strain of nice.
B2
                                                                                                                   Pend.
CRAVE Q* ».1.2 E-1 (O).
                                                                         I RfOC considered the dose levels in both
                                                                         I carcinogenicity studies (rat t aUae) to be
                                                                         I Inadequate.

                                                                          .Assessment based on lack of data concerning
                                                                          carcfnogenicity in huwns i inadequate  animal
                                                                          data.  This assessment ia located on IRIS.
                                                                          OPP has not reviewed this cheerfcal.

                                                                          OPP requests a 90-day study in mice  to  deter-
                                                                          mine whether the doses in the mouse  carcfnog-
                                                                          enicity study would inhibit ChE in plasma.
                                                                          RBC or brain or cause other toxic  effects.

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DATE: 05/27/98
             OFFICE Of PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                              PACE: 24
           CHEMICAL
  CURRENT OPP
CLASSIFICATION
        TUMOR TYPE / SPECIES
 POTENCY Q*
   VALUE
                                                                                                            SAP
                                                                                                           CLASS
                                                                    CRAVE
                                                                    CLASS
                   COHKENTS
Phosphamidon
  CAS No.  13171-21-6
  EPA Che* Code:  015201

ftiosphfne
  CAS Ho.  7803-51-2
  EPA diem Codt:  066SOO
Phostebupfrim (Bay mat 7484)
  CAS  No.  96182-55-5
  EPA  Chem Code: 129606

Picloram (* sall«)
  CAS  No.  1918-02-1
  EPA  Chem Code: 005101

Piperonyl  butoxide
  CAS  No.  51-03-6
  EPA  Chem Coda: 067501
 Polychlorineted biphenyls
   CAS No. 1336-36-3
   EPA Chem Codt: 017801
 Prallethrln (ETOC)
   CAS No. 23031-36-91
   EPA Chem Code: 128772

 Prtmisulfuron-mtthyl
   CAS No. 86209-51-0
   EPA Chem Code: 128973

 Prochloraz
   CAS No. 67747-09-5
   EPA Chen Code: 128851

 Procynidone (Sunileit)
   CAS NO. 32809-16-8
   EPA Chen Code: 129044
  rodiamfoe (Rydex)
   CAS No. 29091-21-2
   EPA Chew Code: 110201
D (CRAVE)
                                B2 (CRAVE)
C(q>
B2
                 Bladder transitional cell earefr
                 Hepatocellular carcinoma; Sprague-Dattley
                 rats (M>
                                                                           Assessment based on  lack'of data concerning
                                                                           carcinogen!city  in hunans f inadequate data
                                                                           In animals.  This assessment is located on
                                                                           IRIS.  OPP has not reviewed this chemical.
                 Increased incidence of hepatocellular
                 tuaors (N « F) (adenomas, carcinomas
                 combined edenomaa/carcincmas In mala* ft
                 adenoma* In females); CD-I mice
                        *
                 Hepatocellular carcinoma*; Fischer 344.
                 Sprague-Oeuley t WUtar rate; dd I BALB/cJ
                 mica.  Inadequate yet suggestive evidence
                 of excess risk of liver cancer in huaans
                 by ingest ion, inhalation or dermal contact
Mepatocelluiar adenomas t carcinomas;  CO-1
mice (M t F) IThe 2 dose levels Here these
tuaors occurred were excessively toxicl.

Hepatocellular adenoma t carcinoma.
combined adenoma/carcinoma; CD-I mice  (M *
Ineratitial cell adenoma (H); Pituitary
adenoma (f); Osborne-Mendel rail.  Liver
adenomas t combined adenomas/carcinomas;
B6C3F1 Mice (F>

Thyroid foilIcolar cell neoplasia;
Pancreatic adenomas; Sprague-Dauley rats
(N t F).  Flbroearconat; CO-1 mice  (M)
                                                                                             7.7 E«0
                                                                                                                    B2
                                                                           This assessment is located on IRIS.
                                                                           not reviewed by OPP.
                                                                                                                                                                OPP has
                                                                                            Syn, Beacon.  NCPRC did not recomaend to re-
                                                                                            peat the mouse study.
                                                              1.5  E-1
2.35 E-2
1.92 E-2
0* Potency
rate rats.
                                                                                                         2.35 E-2 female mice; 1.92 E-2

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DATE: 05/27/98


           CHEMICAL
                                            OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                            PAGE: 25
                              |   CURRENT. OPP
                               CLASSIFICATION
                        TUMOR TVPE / SPECIES
 POTENCY Q* I   SAP    1 CRAVE
   VALUE    I  CLASS
                                                                                                                                            COMMENTS
Profenofos  (Curacron)
  CAS Ho. 41198-08-7
  EPA Che*  Code:  11 HOI

Promton
  CAS No. 1610-18-0
  EPA Chcm  Code:  080604

.Prone tryn
  CAS No. 7287-19-6
  EPA Che*  Code:  080805

PronsMide (Kerb)
  CAS Mo. 23950-58-5
  EPA Che*  Code:  101701

Propachlor
  CAS No. 1918-16-7
  EPA Che*  Code:  019101
 Propanocarb hydrochtorlde
   CAS No. 25606-41-1
   EPA Che* Coda: 119302
 Propargite (Onlte)
   CAS No. 2312-35-8
   EPA Che* Code: 097601

 Prop*tine
   CAS No. 139-40-2
   EPA Che» Code: 080808
 Propiconatole (Bsmer/TUt)
   CAS Ho. 60207-90-1
   EPA Che* Code: 122101

 Propylene oxide
   CAS Ho. 75-56-9
   EPA Chew Code: 042501
 Prosulfuron (CGA-152005)
   CAS No. 94125-34-5
   EPA Chem Code: 129031
likely
C(q)
82 (CRAVE)
                 Masaury tutor; Sprague-Dauley rat* (F)
                 Hepatocelluler  adenomas/careinosas; B6C3F1
                 ft C57ll6xC3h/Anf Mice  (M)
                                                Multiple tuBors/sultiple sites; Rare stom-
                                                ach tueor; Fischer 344 rat (M); Thyroid
                                                tutors ft grenulosa/theea celt tuMrc;
                                                Spraffue-Dauley rate (N ft F).
                                                Hepatocellular tuaors; CO-1 Mice (M)
                                                Statlaticatly significant increase* in
                                                undlfferentiated aarcaaus in the jejunui;
                                                CrUCOBR rat (M ft F).

                                                StatUtically •ionificant Increase* in
                                                •Maary 9| and adenonat. carclnoM* and
                                                caabined adehoMt/carcinoM*; Sprague-
                                                Dauley rat (F)

                                                Hepatoceltuar •denomas, carcihows. ft
                                                adenoaMS/carclnojMS coMbined; CD-I Mice
                                                00

                                                Benisn ft •allgnant tuwre at the aite of
                                                exposure O»en exposed by sUxrutaneous in-
                                                jections (NMRI mice), by Inhalation
                                                (F344/H, CpBrUU Uistar rata ft B6C3F1 mice)
                                                ft by gavage (Sprague-Oauley rats).

                                                Nanawry gland adenomas ft adenocarcinomas
                                                (F); Interstitial cell tutors (M);
                                                Crl:CO(SO)Blt rats
                                                                                            1.54 E-2
                                                                                             1.71 E-2
                                                             4.45 E-2
2.4 E-1 (0)
3.7 E-6 (I)
                                                                                                                   Pend.
                                                                                   82
                              A linear low-dose approach'for htnen risk
                              characterisation C extrapolation of risk
                              should be based on both  neoplastic (ovarian
                              tutor* (rats) ft liver tunors (M nice)} t non-
                              neoplestlc (liver hypertrophy (Mice) lesions.

                              RFDC considered the carcinogenic!ty phase of
                              the rat atudy to be unacceptable.  The mouse
                              carcinogenicity atudy Has also considered
                              unacceptable.

                              HCPKC deternined the mouse carcinogenicity
                              atudy to be inadequate.  However a new study
                              is not required.

                              HCPRC recosswnded that for the purpose of
                              risk eharacteriiation a  ton-dose extrapolat-
                              ion swthodolgy (0.1*) be  applied to the animal
                              data.
This assessment is located on IRIS. WP has
not reviewed this Chemical.

-------
JE: 05/27/98
         CHEMICAL
Tethrlnt
 CAS No. 121-21-1.
 EPA Chew Cod*: 069001

Ttdaben
 CAS No. 96489-71-3
 EPA dim Code: 129105

 TlMthanil  •
 CAS No. 55112-28-0
 EPA Chen Code: 288201

 M-ithlobBC-sodiuB)
 CAS NO. 1233*3-16-8
 EPA Chest Code: 078905
 i indorse (Facet)
  CAS No. 84087-01-4
  EPA Che* Code: 128974

  litelofop ethyl (Assure)
  CAS No. 76578-H-8
  EPA Chen Code: 128201
  :ss*thrin
  CAS No. 10453-86-8
  EPA Che* Code: 097801

  iMulfuron  (OPX-E9636)
  CAS No. 122W»-*f-0
  EPA CheevCode:  129009

  itenone
   CAS  No. 83-79-4
   EPA  Oie» Code:  071003

  •lenitn end compound*
   CAS No. 7782-49-2
   EPA Chea Code:  072001
   Iver
   CAS NO. »**•»:*
   EPA Chen Code: 072501
  CURRENT OPP
CLASSIFICATION
             OFFICE OF PESTICIDE PROGRAMS LIST Of CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL


                         TUMOR TYPE / SPECIES
                                                                                                                                                          PAGE: 2ft
                POTENCY fl*  I   SAP     CRAVE
                  VALUE     I  CLASS   | CLASS
                                                                                                                                           COMMENTS
                              Deferred
                 liver adenomas, carcinomas * combined
                 adenoma/carcinoma; CD-1 Mice (M).
                 Rare kidney tubular adenomas, eerclnoe«« ft
                 cort>imd •denow/eerclnoM; Crl.-CDBR rats

                 '<">•  ..'-.'     '  ••.
                 Equivocal  Increase Iri pencreatlc aclnar
                 cell adenoMt;.Ulster rets (N).
combined);
               1.05 E-3
               1.25 E-2
liver (adenomas C caret
CD-I mica (M).
                                                                                     Def.
  D (CRAVE)
                                D (CRAVE)
                                    »arcoma» have been Ind-
                     eater^tation of foil. I d sc.
                   of silver.  Interpretation of these find-
                   ings has been questioned due to the phen-
                   oMnen of solid-state ctrelnogenesls.
                                                                                          | Classification uiil be reconsidered pending
                                                                                          I HCPRC review of the laboratory pathology peer
                                                                                          I review.
                                                                                            Referred to HCPRC by RFDC.
                                                                          1st Potency Q* value, is based upon male rat
                                                                          kidney tufcuIar (adenomas  and/or adenocarcin-
                                                                          MS) tuaors.  2nd value based on nale souse
                                                                          liver (adenomas and/or carciiwaus) tuners.
                                                                                            HCPRC concluded that limitations in the data
                                                                                            fro* the anuse study precluded an accurate
                                                                                            Interpretation of carcinogenic risk.  No ne«
                                                                                            anlMle studies are required.

                                                                                            Referred to HCPRC by RFDC.
                                              Assessment based on inadequate huwn data •
                                              inadequate evidence of carcinogenicity in
                                              anisMlf. This assessment is located^! IRIS.
                                              OPP has not reviewed this chemical. '
                                                                                                                          This assessment is located on IRIS.
                                                                                                                          not reviewed this chemical.
                                                                                                                                                              OPP has

-------
DATE: 05/27/98
                                            OFFICE OF PESTICIDE PROGRAMS LIST OF CHEHICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                             PAGE: 27
           CHEMICAL
t\CURRENT OPP
CLASSIFICATION
                                                         TUMOR TYPE / SPECIES
                                             POTENCY 0*
                                               VALUE
 SAP
CLASS
CRAVE
CLASS
                                                                                                                                             COMMENTS
SUvex  <2,4,5-TP>-
  CAS No. 95-72-1
  EPA Che*  Code: 082501
SiMttne
   CAS No.  122-34-9
   EPA Chew Code:  080807

Sodiun onadine
   CAS No.  15922-78-8
   EPA Chen Code:  088004

 Sulfellate
   CAS Mo.  95-06-7
   EPA Che* Code:  039001
 Sulfentrazone
   CAS Ho. 122836-35-5
   EPA Chea Code: 129081

 Sulprofoe (Herafos/Bolatar)
   CAS Ho. 35400-43-2
   EPA Chen Code: 111501

 Sumilarv (Pyriproxyfen)
   CAS No. 95737-68-1
   EPA Chen Code: 129032

 TCHTB (Busan 72)
   CAS No. 21564-17-0
   EPA Chen Code: 035603

 Tebuconazole (Folicur)  -
   CAS No. 107534-96-3
   EPA Chen Code: 128997
  Tebufenoxide
    CAS No.  5902-51-2
    EPA Chen Code: 129026

  Tebuthiuron
    CAS No.  34014-18-1
    EPA Chen Code: 105501
0 (CRAVE)
C(q)
3 (IARC)
28  OARC)
Pituitary gland carcinomas; MaaBary gland
carctnoMi; Sprague-Dawley rats (F)
                                                                                             1.2 E-1
Maiawy gland tuaors (F). lung tutors 
-------
ITE:  05/27/98
          CHEMICAL
  CURRENT Off
CLASSIFICATION
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL


            TUMOR TYPE / SPECIES
                                                                                                                              PAGE: 28
 POTENCY 0*  I  SAP   I CRAVE
   VALUE    I CLASS  I CUSS
                                                                                                                                            COMMENTS
eflubehzuron
 CAS No. 83121-18-0
 EPA Q»m Code: 129048

srbectl
 CAS No. 5902-51-2
 EPA Chem Code: 012701

trbufos
 CAS No. 13071-79-9
 EPA Chen Code: 105001

erbuthylazine
 CAS No. 5915-41-3
 EPA them Code: 080814
erfautryn
 CAS NO. 886-50-0
 EPA Che*  Code:  080813
 errazole
 CAS NO. 2593-15-9
 EPA Chen Code:  084701
 etrachloroethane, 1,1,2,2-
  CAS Ho.  79-34-5
  EPA Chen Code: 078601

 etrachlorvtnphos (Garden*)
  CAS No.  961-11-S
  EPA Chen Code: 083701
 etrenethrin
  CAS NO. 7696-12-0
  EPA Che* Code: 069003

 hslUun(l) sulfate
  CAS No. 7446-18-6
  EPA Chen Code: 080001
 rhiafluamide (FOE 5043)
  CAS No. 142459-68-3
  EPA Chen Code: 121903
Pending
                               82
 C (CRAVE)
 CCq)
                                                                                                                          •eferrad to HCPRC by RFDC.
    Benign  interstitial cell tuaors of the
    testes  (M), mamaary gland carcinomas (F>;
    Tif:RAIf rat*
    Mamary  (adenomas/adenocarcinomas); Liver
    (adenomas/carcinomas) (F)j Thyroid follie-
    ular  (adenomas/carcinomas); Testicular
     Interstitial celt adenoM  (N); CR CO-1
    •ice.

    Multiple tuajora  (liver, bile duct, mammary
    gland,  thyroid,  I tastes)  i cholanglocar-
    cinema  
-------
DATE: OS/27/98
               OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
                                                                                                                                                             PAGE: 29
           CHEMICAL
I  S°
I  CIA!
CURRENT OPP
 iSSIFICATION
TUMOR TYPE / SPECIES
                                                                                              POTENCY 0*
                                                                                                VALUE  .
 SAP
CUSS
CRAVE
CLASS
                                                                                     COMMENTS
Thiaiopyr  ice 
-------
DATE: 05/27/98
             OFF ICE,Of PESTICIDE PROGRAMS LIST Of CHEMICALS EVALUATED FOR  CARCINOGENIC POTENTIAL
                                                                                                                                                             PAGE: 30
CHEMICAL
Tribufos (TrtbuplKW/OEF)
CAS No. 78-48-8
EPA Cheat Code: 074801
CURRENT OPP
CUSSIFICATION
likely (high
dMM>
Unlikely 
-------
ATEl 05/27/98
             Off ICE Of PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGEHIC POTENTIAL
                                                                                                                                                            PAGE:  31
          CHEMICAL
  CURRENT OCP
CLASSIFICATION
        TUMOR TYPE / SPECIES
POTENCY 8*
  VALUE
 SAP
CLASS
CRAVE
CLASS
COMMENTS
Hphenyltin hydroxide
 CAS Ho. 76-87-9
 EPA ChM Code: 083601
roysani polyphase  (IPBC)
 CAS No. 55406-53-6
 EPA Chea Code: 107801

OMM
 CAS No. 57-14-7
 EPA Chea Code: 600018

MP-488  (PAL  6000)
 CAS No. 111578-32-6
 EPA Che* Code: 129025

niconazole  (Prunit)
 CAS Mo. 83657-22-1
 EPA Chen Code: 128976

 inclozolin  (Ronilan)
 CAS No. 50471-44-8
 EPA Che* Code:  113201
Hilt* phosphorus
  CAS No. 7723-14-0
  EPA Chea Code: 066502
 lyU
  CAS No. 1530-20-7
  EPA Che« Code: 086802
 !inc and compounds
  CAS No. 7440-66-6
  EPA Chea Code: 129015

 Mneb
  CAS No. 12122-67-7
  EPA Chen Code: 014506
Not Likely
•2
                 Pituitary gland adenoaa (F); Leydlg cell      2.8 E-0     •  02
                 tutors (M); tlistar rat.  Hcpatocettular  .
                 edenoaas (N i F); coafcined hepatocetlular
                 (adenoM i/or earelnoaa) (F); NMRI •ice.
Multiple sites (eg. lungs, vessels. liver- I  4.6 E-1 (N)  I Defer.
i kidney); Multiple species, strains 1     I  3.1 E-1 (F)
studies.
                 Hepatocelluter adenoaa*, carctnonas t -
                        S/carclnoaas cosfctned; CO-1 aice
92
                               0 (CRAVE)
                               D (CRAVE)
                               D (CRAVE)
 3 (IARC)
Statistically significant increases in
Multiple tuaor -types (testiculer Leydig
cell & prostate adenoaas) and ovarian
adenoass in feaales; Ulster rats
        UDMM is the aetabolIte/breakdoun product of
        Daainoxide (Alar).
        (Syn. unsyaaetrical  1,1-dinethylhvdraxine)
        NCPRC concluded that for  the purpose of risk
        characterization,  a non-linear approach -
        Margin of Exposure (NOE)  should be wed for
        quantisation of huasn risk.

        Assessaent based on lack  of data concerning
        earcinogenlclty in huaans or animts.
        This assessaent is located on IRIS.  OPP has
        not reviewed this  cheaical.

        Assessaent based on lack  of data concerning
        carcinogeniclty tn huaans I inadequate anfaal
        data.  This assessaent is located on IRIS.
        OPP has not reviewed this cheaical,

        Assessaent based on inadequate evidence in
        tiuaans t aniaals.   This assessment is located
        on IRIS.  OPP has  not reviewed this cheaical.

-------
                  EPA WEIGHT-OF-THE KVTnENCE CATEGORIES

 Group A -  Human  carcinogen
 Group. B -  Probable  human carcinogen
         Bl -  Indicates limited ..human evidence
         B2 -  Indicates sufficient evidence in animals and inadequate or
              no  evidence in humans
 Group C -  Possible  human carcinogen
 Group D -  Not classifiable as to human carcinogenicity
 Group E -  Evidence  of noncarcinogenicity for humans


              PROPOSED EPA WEIGHT-QF-THE EVIDENCE CATEGORIES

 Known/Likely  - This category of descriptors is appropriate when the
               available tumor effects and other key data are adequate to
               convincingly demonstrate carcinogenic potential for humans.


 Cannot  Be  Determined -This category of descriptors is appropriate when
                       available tumor effects or other key data are
                       suggestive or conflicting or limited in quantity  and,
                       thus, are not adequate to convincingly demonstrate
                       carcinogenic potential for humans.

Not Likely -  This is the appropriate descriptor when experimental evidence
              is  satisfactory for deciding that there is no basis for  human
              hazard concern.
                            IARC
Group 1  - The agent  (mixture) is carcinogenic to humans
Group 2A - The agent  (mixture) is probably carcinogenic to humans
Group 2B - The agent  (mixture) is possibly carcinogenic to humans
Group 3  - The agent  (mixture, exposure circumstance) is not classifiable
           as to its carcinogenicity
Group 4  - The agent  (mixture, exposure circumstance) is probably not
           carcinogenic to humans                              •
CAG
CRAVE
Def.
Defer.
F
HCPRC
HAZID
(I)
IARC

Int.
IRIS
M
(O)
OPP
ORD
Pend.
Q*
                                ACRONYMS

         Cancer Assessment Group
         Carcinogen Risk Assessment Verification Endeavor
         Deferred
         Deferred
         Female
         Health Effects Division Carcinogenicity Peer Review Committee
         Hazard Identification Assessment Review Committee
         Health Effects Division
         Inhalation (ug/cu.m)"1
         International Agency for Research on Cancer, World Health
         Organization
         Interim
         Integrated Risk Information System
         Male
         Oral (mg/kg/day)"1
         Office of Pesticide Programs
         Office of Research and Development
         Pending

-------
SAP   . - FIFRA Scientific Advisory Panel
SAB    - Scientific Advisory Board

-------
 US EPA Pesticidal Chemicals Classi...able or Possible Human Carcinogens
      http://www.epa.gov/pesticides/carlist/table.htm
SEPA
               vx
Office of Pesticide Programs
                     Pesticidal Chemicals Classified as Known, Probable or Possible
                                            Human Carcinogens

                Group A Pesticides: Human Carcinogens; Not Classified by OPP
                Group Bl Pesticides: Probable Human Carcinogens with Limited Human Evidence- Not
                Classified by OPP
                Group B2 Pesticides: Probable Human Carcinogens with Sufficient Evidence in Animals and
                Inadequate or No Evidence in Humans; Classified by OPP      ,
                Group B2 Pesticides:  Not Classified bv QPP   •      .
                Group C Pesticides: Possible Human Carcinogens; Classified by OPP
                Group C Pesticides: Not Classified by OPP
                Other Pesticides: Not Applicable under Current Classification; Classified by OPP
                Other Pesticides: Not Classified by OPP
                Classifications under Proposed Revised Guidelines: Classified by OPP
                Definitions

                                              Group A Pesticides
                                             Human Carcinogens
                                             Not Classified by OPP

           Note: Sine? the evaluation of many of these chemicals is an ongoing process, the information on this iist may change,
           i.e., a classification may change.                                             '

           Goto Top of Page
Active Ingredients
(Arsenic, inorganic
Benzene
jChromium VI
Coal Tar (Coke Oven
Emissions)
Ethylene Oxide Group
(IARC, 1994) -see
also under Group Bl
Registration Date ] Use Pattern
1972
1948
'
- 194$
1957
indoor/outdoor;
wood preservatives;
food use
food use;
animal use
Regulatory Status
Food uses voluntarily
cancelled 1993
remaining uses are ant
baits (in crp) and wood
preservatives
Voluntary cancellation
7/31/85
wood preservative |(see Arsenic, inorganic)
indoor/outdoor use;
wood/non-wood use
food use;
non-food use;
fumigant
All uses canceled
5/15/86 except wood
use (label restrictions) ]
Tolerances reassessed
by 8/99
                                              Group Bl Pesticides
                          Probable Human Carcinogens with Limited Human Evidence
                                             Not Classified by OPP

           Note: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change,
           i. e., a classification may change.

           Go lo Top of Page
I of 12
                                                                                              7/16/983:29PM

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US EPA Pesticidal Chemicals ClassL.able or Possible Human Carcinogens
http://www.epa.gov/pesJicides/carlist/Uble.htr
Active Ingredients
Acrylonifrile
UaHmiurn
i

VTCUMJIC =
- ' \
• • \
lEthylene Oxide !
i(OHEA, 1985) -see |
also under Group A !
Formaldehyde |
Registration Date
1/1776
1959
1948

1957
i
1948
I Use Pattern
'stored tobacco;
(food processing areas; .
iterrniticide
|lawn/turf
i
i
iwood preservative
1 • •
[food use;
Inon-food use
jfooduse
l • . • -.: :
Regulatory Status
Canceled 10/28/80 j
t 	 -j- 	 r .J
Last product canceled I
12/29/86
Classined.as restricted
use in 198 5
Tolerances reassessed
by 8/99
olerances reassessed
by 8/99
                                                Group B2 Pesticides   .
              Probable Human Carcinogens with Sufficient Evidence in Animals and Inadequate or No
                                                Evidence in Humans
                                                  Classified by OPP

            Note: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change,
            i.e., a classification may change.
            Go to TOD of Page
Active Ingredients
Acetochlor
Aciflurofen, sodium salt
Registration Date
3/11/94
-
,9/20/M -
Amitrole I960
i . ' '
Cacodylic Acid
(Captafol
Captan
Chlordimeiorm
i
Chloroaniline
1954
1962
1949 .
1970
1967
Cyproconazole j 12/22W
•i . • " | ' '
jDaminozide (Alar)
r,2-Dichloropropene
(Telone)
i
	 	 "1963
i
- — ~ 1960
Use Pattern
Food use (com and .
soybeans)
food use
outdoor use (right of
ways)
food use
food use
food use
food use (cotton only)
seed treatment;
foliar treatment
food use
food uses;
non-food uses
food uses
Regulatory Status
^ . — -i —
tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
?LED issued 11/22/96
n> — I 	 ~3 —
Tolerances reassessed
by 8/99
(All products
voluntarily cancelled
5/15/87
Tolerances revocation
by 8/99
imf. 1 	 T 	
Tolerances reassessed
by 8/99'
(yy-u'— .... . ••• • 	
Voluntary cancellation
9/19/88
uses canceled
FR 3702 1977
(w — I 	 i 	 ~ — 3 —
Tolerances reassessed
by 8/99
Tolerances revocation
3/19/90
nrr — r — I 	 " — '
No tolerances
established at the time
of registration under
 2 of 12
                                                                                                     7/16/98 3:29 PM

-------
US EPA Pesticidal Chemicals ClassL.able or Possible Human Carcinogens
hnp://www.epa.gov/pesticides/carlist/table.htm
                                                                                     \\JSDA
                                                                                     iCurrently in Special
                                                                                     IReviewfor
                                                                                     jgroundwater issues
1,1-Dimethylhydrazine i 1960 . food uses; Tolerances revocation
(UDMH) non-food uses by 3/1 9/90
Dipropyl ; . 1958 - , |
isocinchomeronate !
(MGK 326) . | . -
Fenoxycarb
I
':
Folpet :
V
Furrnecyclox
Haloxyfop-methyl
Lactofen
Mancozeb
.
Maneb '
i
Metam Sodium
Orthophenylphenol .
Oxythioquinox
Procymidone
Pronamide • J
. •
Propargite
i "
Propoxur (Baygon)
1985
1948
pending registration
non-food use (topical (Routine registration
animal use) {activities;
no pending use
food uses;
non-food use
(non-bearing fruit
trees);
indoor/outdoor;
domestic animal
food use
wood preservative
pending registration jno food uses
3/18/87
1962 ..:
1954
i 1955
1948
1963
import use only
10/11/72
1976
1976
IPropylene Oxide j 1971
Terrazole
Thiodicarb
jTriphenyltin hydroxide
1966
•
2/10/84
2/26/85
food use •
food use ,
v
food use
food use
food use
food use
EUP on pears expired
8/97;
new uses (pome fruit,
citrus, tree nuts,
pasture grasses and
cucurbits established)
Tolerances reassessed
by 8/99
No action from.
company since 1987

Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/02
Tolerances reassessed
by 8/99
Tolerances reassessed
by8/99
food use (wine grapes) (Tolerances reassessed
jby 8/99
food use
food use
no food uses;
greenhouse;
indoor/outdoor uses
fbocTuse
food use
food use
food use
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99.
RED to be issued in
early 1998 .
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
|by8/99
                                                   Group B2 Pesticides
3 of 12
                                                                                                        7.M6'Q8 3-29 PM

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US EPA Pesticidal Chemicals ClassL.able or Possible Human Carcinogens
http://www.epa.gov/pesticides/carlist/table.htm
              Probable Human Carcinogens with Sufficient Evidence in Animals and Inadequate or No
                                                 Evidence in Humans
                                                Not Classified by OPP

            Note: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change,
            i.e., a classification may change.

            Go 10 Top of Page
Active Ingredients Registration Date
Use Pattern Regulatory Status
Acetaldehyde - This pesticide no longer has registered food uses and UPF is m the process oi
revoking Tolerances associated with this chemical.
Aldrin
1
1949
'
fooduse; i
aon-fooduse; 1
termiticide <
\11 uses including
ermiticide uses
:anceled 1989
j Aniline - not registered as active ingredient but as an analog
Aramite
1 • ' •
1951
use on roses
. ... 1
All products canceled
by 1984
jAzobenzene - There are no records indicating registered or pending pesticide products.
IBis(chloroethyl) ether - There are no records indicating registered or pending pesticide products.
jCarbon Tetrachloride
i
Chlordane
I ,
(Chloroform
1,2-Dibromo-
3-chloropropane
(DBCP)
iDibromoethane, 1,2
j(EDB)
j[=Ethylene dibromide]
|
i
1950
5/18/78
fooduse;
fumigant
fooduse;
termiticide
Some uses voluntarily
canceled 1985;
remaining uses canceled
1988
All uses canceled by .
1988
4/23/5
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US EPA Pesticidal Chemicals ClassL.able or Possible Human Carcinogens
http://www.epa.gov/pesticides/carlist/table.htm
            [Epichlorohydrin - There are no records indicating registered or pending pesticide products.
jtmyiene tmourea j inert ingredient only
i
i - i
TJT — i — in 	 ' — 	 	 	 	
Heptachlor
'o«— .* in 	 • j 	
Heptachlor epoxide
i
i
Hexachloroberizene
m 	 in 	 —
Hexachloro '
cyclohexane, tech.
Lmdane
I 1952
j
1952
9/28/71
i960
9/2/52
in various chemical i 1 his inert no longer in
formulations Ipesticide products by
11987
food use;
non-food use;
termiticide
food use;
non-food use;
termiticide
seed treatment
tooa use
food use;
non-food use;
indoor/outdoor use
All uses canceled 1988
except fire ant use;
RED issued in 1992 for
fire ant use
All uses canceled 1988
except fire ant use;
RED issued in 1992 for
fire, ant use
voluntarily canceled
7/6/84
Some products canceled
7/21/78;
others reformulated to
lindane .
Tolerances reassessed
by 8/99
, etliylene Chlonde (see Uichloromethane) 	 ~ 	
Mirex
Pentachlorophehol
fn 	 n 	 n — i 	
Perchlorethylene
i
7/30/75
1948
1959
technical formulation
only
no food uses;
wood preservative
non-food use;
indoor/outdoor
Canceled 7/1/87 .
Wood uses canceled in
1986;
ion wood use restricted
labeling and currently
in Reregistration
Process
Canceled in 1992 for
ion support through
Rereaistration
poiycftionnated biphenyls - Considered contaminants. Elimination of all active and inert uses "
jlx/V ., ..
p-Propiolactone - There are no records indicating registered or pending pesticide products.
Toxaphene
19/4 food use . (Canceled 1982
inchlorethylene | 1949 (indoor/outdoor [Products canceled 19S5
inchlorphenol 2,4,6 |. i960 (disinfectant -. ~'(
Canceled 1987
                                                Group C Pesticides
                                           Possible Human Carcinogens
                                                 Classified by OPP

          Note: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change
          i.e.,-a classification may change.                     '
         Go to Top of Page
          j     Active Ingredients     |  Registration Date  |     Use Pattern
          iAmitraz         -            |       3/31/75       [food use	
        Regulatory Status
       Tolerances reassessed
       by 8/99
                                                                                                    7/16/983:29PM

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US EPA Pesiicidal Chemicals ClassL.abJe or Possible Human Carcinogens
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Asulam ' 10/24/75 Tooduse 1 1 olerances reassessed
jby8/99
Atrazine 1959 tooduse;
non-food use 1
Benomyl 1969 looduse;
lindoor/outdoor use
i • i
Bifenthrin
Bromacil
•
Bromoxynil
Calcium Cyanamide
Carbaryl
Clofentezine
jCyanazine
Cypermethnn
Dacthal •
Dichlobenil
Dichlorvos (DDVP) .
Diclofop-methyl
Dicofol
Difenoconazole
Dimethenamid (SAN 682H)
Dimethipin (Harvade)
Dimethoate
Dinoseb
Ethalfluralin
i ,
[Ethofenprox
Fenbuconazole
10/2/85 1
1963 11
i
4/25/88 -
2/25/72 |
• -
1963
• j/tO/89
12/6/71 .
6/12/84
1958
1982
1948
3/31/80-
1957
8/4/94
.- ,. ':3/5/98. .
• 8/13/82
tooduse
food use;
non-food use;
indoor/outdoor use
food use
.
food use;
non-food use
food use;
non-food use
food use;
non-food use
food use
food use
food use;
non-food use
food use;
outdoor use
food use;
non-food use
food .use
food use;
outdoor use
food use (wheat use
only)
food use
plant growth regulator
1962 tooduse;
non-food use
1976
12/5/83-
food use; •
non-food use;
indoor/outdoor use
food use;
non-food use;
indoor/outdoor use
pending registration non-rood use
2/5/92
ifood use
L olerances reassessed
?y 8/99
Folerances reassessed
?y 8/99
tolerances reassessed
?y8/02
Folerances reassessed
by 8/9?
Folerances reassessed
by 8/99
Canceled 1984
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/02
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/06
Tolerances reassessed
by 8/02
Tolerances reassessed
by 8/99
Ail uses canceled
6/9/89
Tolerances reassessed
by 8/99

Tolerances reassessed
by 8/99
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Fipronil 1 5/1/96 food uses (corn only); Corn use registered
i (domestic animals; 1 1/14/97;
indoor bait stations jother uses pending
Fluometuron \ 8/7/73 ifood use (grapes and iTolerances reassessed
- cottononly) by 8/02
Fomesafen 1- 4/10/87 food use (soybeans [Tolerances reassessed
1 (only) (by 8/99
Hexaconazole j 9/26/96 (import use food use (import use [Tolerances reassessed
only) Jon bananas) jby 8/99
Hexythiazox (Savey) . -4/13/89
; ,
Hydramethylnon (Amdro) 8/20/80
.•••••''
food use;
non-food use
food use; •:
non-food use
Hydrogen cyanamide 11/29/93 plant growth regulator
'.-'•: (grapes and kiwi)
Imazalil
Isoxaben
Linuron
2-Mercapto benzothiazole
..
Methidathion
[Methyl 2-benzimidazole
carbamate (MBC)
Metolachlor
1 . '
Molinate
[Nitrbfen
Norflurazon
N-Ocryl bicycloheptene
dicarboximide (MGK-264)
Oryzalin
Oxadiazon
Oxadixyl
Oxyfluorfen
7/18/83
6/16/89
1/2/67
1956
2/12/76
5/3/90
. 4/1/77
1965,
12/7/66
.1/21/74 •
.3/15/50
3/15/74
. 5/24/77^
2/27/92
5/17/75
food use
food use
food use;
outdoor use
aquatic indoor
food use
no food uses;
sanitizer,
algicide
food use
food use (rice only)
food use
food use
food use;
non-food use;
indoor/outdoor use
food use
{food use
i
food use
food use
lolerances.reassessed
t>y8/99
Folerances reassessed
t>y 8/02 '
New uses under
consideration
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/06
Tolerances reassessed
by 8/02
Products canceled
due to maintenance
fees and DCI.
Tolerances
revocation by 8/02
Tolerances reassessed
by 8/99
RED scheduled after
2002 -
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Voluntary
cancellation 9/15/83
Tolerances reassessed
by 8/02
Tolerances reassessed
by 8/02
Tolerances reassessed
by 8/99
Tolerances reassessed
by8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
7 of 12
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US EPA Pesticidal Chemicals ClassL.able or Possible Human Carcinogens
                                  http://www.epa.gov/pesticides/carlist/table.htm
           (Paradichlorobenzene
           [Parathibii


           Ifendimethalin
        1949       jnon-food use;         'Regular registration
        _____        imdoor/outdoor use    jactivities
        1948~
       7/29/75'
 , (food use
  I

  jtbod use
           (Pentacliforonitrobenzene
           Hermethrin

            'hosmet
      4/11/79

        1966
           FHospEarmdoir
      7/26/60
  [food use;
  (non-food use;
  greenhouse (indoor)
  ifood use;
  non-food use
  food use;          ~
  non-food use
  food use
                       11 olerances reassessed
                       jby 8/99

                       11 olerances reassessed
                       |by8/99 .

                       I olerances reassessed
                       by 8/99
          Fiperonyl butoxide



          Prochloraz
      8/29/57
          Prodiamine


          Fropazine~~
An experimental use
 permit only issued
     11/10/88
      2/7/92
 tooduse;
 non-food use;
 greenhouse (indoor)
                       Tolerances reassessed
                       by 8/99

                       1 olerances reassessed
                       by 8/99-
                       Tolerances
                       revocation by 8/99;
                       products canceled
                       6/15/84.  -

                       Tolerances reassessed
                      by 8/02
 food use
          Fropiconazole
         j4-Pyridazine carboxylic acid,
         2-(4-chlorophenyl)-3-ethyl-
         2,5-dihydro-5-oxo-,potassium
         salt (MON 21200)

         -post FOPA

         jPyrithiobac-sodium
       1961

      8/14/81
     2/26/97
                                                          food use
                                                                                1 emporary tolerances
                                                                               expired 11/21/89
 tooduse;
 outdoor use
 food use
         jbimazine


         |Iebuconazole
     9/29/95

      1959
         (Terbutryn
     7/15/74

     7/29/74
 food use (wheat only)
                      [olerances reassessed
                      by 8/99
                      Tolerances reassessed
                      by 8/99
                      Tolerances reassessed
                      by 8/99
                                         Regular registration
                                         activities;
                                         no new pending uses
tooduse;
non-food use
tood use (peanut)
jnon-tood use
        j2-(Thiocyanomethylthio)
        jbenzothiazole (TCMB)
        jTriadimefon
         Triadimenol


         Trial late
     4/28/89

     2/15/62
tood use (cotton only) [Tolerances reassessed
                     by 8/99

                     Tolerances reassessed
                     by 8/99
                     'i'olerances reassessed
                     by 8/99
                     Tolerances
                     revocation by 8/99
                     (canceled 1/22/91)
                     Tolerances reassessed
                     by 8/99

                     Tolerances reassessed
                     by 8/99

                     Tolerances reassessed
                     by 8/99
                     [Tolerances reassessed
    12/11/69    ~|tooduse;
                  (wood preservative
     8/27/79   	ifood use   	:
food use

tood use
                                                                                             7/16/983:29PM

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US EPA Pesticidal Chemicals ClassL.able or Possible Human Carcinogens
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jTribenuron methyl i 6/30/89
i i
jlndiphane j 2/10/86 .
j 1 rifluraiin 1/15/73
i i . '
! . ' •!
, nrlusulturon-methyl 2/4/92
jUniconazole 7/3/91
1 -•• • ' :'
jvmclozolin 2/11/81
1 ' ' • - '

|food use
itbod use
itbod use
tood use (sugar beets)
plant growth
regulator;
no food uses
food use
by 8/99
lolerances reassessed
by 8/02 ,
lolerances reassessed
by 8/02
lolerances reassessed
by 8/99
1 olerances reassessed
by 8/02
Normal registration
activity
i olerances reassessed
by 8/99
                                                  Group C Pesticides
                                             Possible Human' Carcinogens
                                                Not Classified by OPP
           Note: Since the evaluation of many of these chemicals is an ongoing process, 'the information on this list may change
           i.e., a classification may change.                                                                     s.
           Go to TOD of Page
Active Ingredients
Acrolein
ltJfoVdr>tll/T.rjT.ii(li 	 fC 	
Registration Date .
11/26/75
Use Fattern
aquatic food crops
(agricultural irrigation
waters)
Regulatory Status
Restricted use chemical;
regular registration
activities
ucxacmuiounaiie - llieie aie no records indicating registered or pending pesticide products
ilsophorone
I
i '
jMetnylphenol, 3-
j(m-Cresol)
•I etrachloroethane,
IM2-, • - , '
i ricriioroethane, 1 , 1 ,2-
inert ingredient
•
tood use
J/ 10/80 food use; ~ 	 '
(wood preservative
9/15/78
non-food uses
12/28/49 jnon-fooduse "~
Company has submitted
for review information
rebutting carcinogen
classification
Currently in
Reregistration process
Canceled 7/«7
Canceled 1992 '
                                                   Other Pesticides
                                   Not Applicable under Current Classification
                                                  Classified by OPP

         ,Npte: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change •
        ~i.e.',-a classijication may change.      -

         Go to TOD of Page
                                                                                                      7/16/983:29PM

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 US EPA Pesticidal Chemicals ClassL.able or Possible Human Carcinogens
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I Active Ingredients
lAliette
[Melamine
i
Registration Date
1988
3/88
Use Pattern
food uses
disinfectant;
sanitizers
Regulatory Status !
RED issued 1990;
all products reregistered i
1992 !
KtL> scheduled for j
2002 }
                                                     Other Pesticides
                                      Not Applicable under Current Classification
                                                  Not Classified by OPP

            Note: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change,
            i.e., a classification may change.

            Go to Top of Page
Active Ingredients
Rhodamine 3
THPS
(tetrakis(hydroxymethyl)
phosphonium sulphate
(no classification, but
accepted NTP negative
studies)
Registration Date
inert ingredient; ,
date unknown due to
change in data systems
10/12/95 ,
Use Pattern
seed treatment -
formulations only
indoor commercial use
(antimicrobial uses)
Regulatory Status
Currently reviewing
residue data to
ascertain dietary
exposure;
tolerances
reassessment by 8/99
Normal registration
activities
                                   Classifications under Proposed Revised Guidelines
                                                    Classified by OPP

            Note: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change.
            i.e.. a classification may change.
                                                          Likely
            Go >o Top of Page
Active Ingredients
Chlorothalonil
•
Ethoprop -
Ipcodione
Isoxaflutole
Propachlor
Registration Date
1966
4/88
1980 .
pending registration
9/3/82
Use Pattern
food use;
wood preservative
food uses
.
food use
food use (corn)
food uses
Regulatory Status
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
-
Tolerances reassessed
by 8/99
                                                      Known/Likely
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                         7'16/98 3-29 PV

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              Go lo Top of Page
[  Active Ingredients   j   Registration Date
Dluron                I       57Z8771
                                                              U^TFarteTH
                                                       ~ltbod use
                                     Likely: High Doses/Not Likely: Low Doses
             Go to TOD of Pase
                                                                               1 olerances reassessed
                                                                              by 8/02               j
Active Ingredients
jAiactiior
1
l.ribuphos (JJtit)
Kegistration Date
4/75
6/29/61
Use Pattern
food use :
food use (cotton)
Regulatory Status
1 olerances reassessed
by 8/99
Tolerances reassessed
by 8/99
                                      Cannot Be Determined, But Suggestive
             Go to TOD of Page
Active Ingredients
Benoxacor
Kegistration Date
inert (safener)
Use Pattern
food use
Regulatory Status
lime-limited tolerances
expires 2/98
                                           Definitions
            Analog Back to fable
                        -     a f?™!*!™*1 ^ w similar in structure to another compound.
                 (Experimental Use Permit) Backjojabje
                A permit authorized under FIFRA section 5 that is granted by the Agency to allow
                producer to conduct testing of a new pesticide, i^-airf/iuae.cLiirftiSb
                The testing is generally conducted on ten or more acres of land or water surface EUPs are
                most commonly used for large-scale testing of efficacy and gathering of environmental fate
                                                         data' EUPs « P~ ^ Product Managed
            FQPA (Food Quality Protection Act) of 1996 Back to Table
                Signed into Jaw in August 1996, amended both FIFRA and FFDCA and significantly
                furtftTtafls       ^^    regulatory system- See http://www.ena .^v/oppfeadl/fapa for

            OPP (Office of Pesticide Programs) Back to TOD
                S^iV*6^'? ^n *C Environmental Protection Agency responsible for protecting
                public health and the environment from the risks posed by pesticides It is also OPP's
                responsibility to promote safer means of pest control. OPP and the Office of Pollution
                Prevention and Toxics (OPPT) comprise the two offices within the Office of Prevention
                Pesticides, and Toxic Substances. OPP is comprised of nine Divisions: Antimicrobials- '
                Biological mid Economic Analysis; Biopesticides and Pollution Prevention; Environmental
               .-Fate and Effects; Field and External Affairs; Health Effects; Information Rwourceslnd
           DirrwD™0"5 Jk8!stra5°n; and Special Review and Registration, http://www.era.gov/resticides
           RED (Reregistration Eligibility Decision)  Back to Table             -     /pesuciaes
                RED documents summarize the findings of EPA's reregistration review process for individual
                chemical cases, and reflect the Agency's decisions on risk assessment and risk management
                for the uses of pesticides.  Besides summaries of risk assessments, RED documents include
                requirements for risk reduction, product-specific data to support product reregistration and
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                any additional generic data needed on the active ingredient(s).
           Reregistration Back to Table
                The reevaluation and relicensing of existing pesticides originally registered prior to 1984. The
                purpose of reregistration is to evaluate and approve the older formulations against modem
                scientific and regulatory standards. The process is scheduled to be completed on the older
                active ingredients by the end of 2002.
           Residue Back to Table                        .
                That quantity of pesticide, its degradation products, and/or its metabolites remaining on or in
                the soil, plant parts, animal tissues, whole organisms, and surfaces.
           Restricted Use Back to Table
                A pesticide that is available for purchase ^nd use only by certified pesticide applicators or
                persons under their direct supervision. This designation is assigned to a pesticide product
                because of its relatively high degree of potential human and/or environmental hazard.
           Special Review (SRI Back to Table                                      ;
                This is the process through which existing pesticides suspected of posing unreasonable risks to
                human health, the environment, or non-target organisms-are referred for review by the .
                Administrator or the Assistant Administrator. The review requires intensive risk and benefit
                analyses with the opportunity for public comment. If the risk of any pesticide use is found to
                outweigh social and economic benefits, regulatory action can be initiated. Regulations
                pertaining to Special Review procedures are found at 40 CFR Part 154. Special Review
                formerly was known as Rebuttable Presumption Against Registration (RPAR).
           Tolerances Back to Table
                Maximum permissible levels for pesticide residues allowed  in or on commodities for human
                food and animal feed. Ufnder the Federal Food, Drug, and Cosmetic Act, EPA is responsible
                for establishing tolerances. Whenever a pesticide is registered for use.on a food or feed crop, a
                tolerance or exemption from the requirement of a tolerance must be established. Established
                tolerances and exemptions for pesticide chemicals in or on raw agricultural commodities are
                listed in 40-CFR 180. Tolerances for pesticides in processed food are at 40 CFR 185; and
                tolerances for pesticides in processed animal feed are listed at 40 CFR 186. Tolerances are
                enforced by the Food and Drug Administration and the U.S. Department of/Agriculture.
           USDA iUnited States Department of Agriculture! Back to Table
                The Federal Agency responsible for the  Food Stamp Program and certain other food and
                nutrition programs, the farm commodity programs, the crop insurance program, the
                Conservation Reserve Program, rural development, agricultural research and education,
                agricultural credit, international food aid, food marketing and inspection, forestry, and certain
                nutrition programs, http://www.usda.gov/
                            Table Introduction I OPP Home I EPA' Home I Comments •
                                      Site Map I Search OPP 1 Search EPA

                                       www.epa.gov/pesticides/carlist/table.htm
                                              updated June II, 1998
12 Of 12                                                                                           7/16/98 3:29 PM

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