UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON, O.C. 20460
JUH 11 1998
off tee of
PM6VEMT1QN. PESTICIDES
AND fOXC SUBSTANCES
MEMORANDUM:
SUBJECT; Office of Pesticide Programs List of Chemicals Evaluated for Carcinogenic Potential
FROM: William L. Burham, Chief }*JL <3/xT>"~-^
Science Analysis Branch \JW Q* U
Health. Effects Division (7509C)
TO: Division Director HED, RD, SRRD and EFED
Associate Directors, HED
Branch Chiefs, HED
The attached list provides a quick overview-of compounds evaluated for carcinogenicity by the
Health Effects Division (HED) of the Office of Pesticide Programs (OPP). Chemicals evaluated by
other review groups are listed as welt and HED looks to these evaluations until an internal HED
evaluation has been performed. • Since the evaluation of many of these chemicals is an ongoing
process, the information OQ this list may'change ami become put of date, i.e., the classification and
Qi* may change. Therefore, the list should not be used as the sole reference, without checking on
the. present status of a compound. Updated lists will be distributed in the future on a semi-annual
basis.
Unless otherwise indicated, the classification of chemicals istased on the HED carcinogenicity
peer review process or the HED hazard identification assessment review process, applying the
Agency guidelines for carcinogenicity assessment. Evaluations by other groups are indicated by
their acronyms: Cancer Assessment-Group (CAG), Carcinogen Risk Assessment Verification
Endeavor (CRAVE), International Agency for Research on Cancer, World Health Organization
(IARC), Office of Research and Development, U.S. EPA (ORDX Scientific Advisory Board (SAB)
and FIFRA Scientific Advisory Panel (SAP). For those chemicals where different.groups
suggested different classifications, the "final" OPP classification is listed under the column
"Current OPP Classification". The Potency (Qi*), unless otherwise indicated, is based on the oral
route. The units for the oral and inhalation Qi* are (mg/kg/day) 'l and (ug/cu.m) "', respectively.
If any corrections are necessary or further information is required please contact Rick Whiting
(703-305-5473) or myself (703-305-6193).
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DATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 1
CHEMICAL
CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTEMCT Q* I SAP
VALUE I CLASS
CRAVE
CLASS
COMMENTS
2,4-0
CAS No. 94-75-7
EPA Chm Codes 030001
2-Benzyl-4-chlorophenol
CAS No. 120-32-1
EPA Chat Code: 062201
AC 263222 (Cadre herbicide)
CAS No. 81534-60-3
EPA CheavCode: 129041
AC 2V9.263
CAS No. 11431-32-9
EPA Che* Code: 129171
Acephat*
CAS No. 30560-19-1
EPA Chea Code: 103301
Acetaldehyde
CAS No. 75-07-0
EPA Chen Code: 202300
Acetamide
CAS No. 60-35-5
EPA Che* Code:
Acetochlor
CAS No. 342S6-B2-1
EPA Che* Code: 121601
Acetone
CAS No. 67-64-1
EPA Chen Code: 044101
Acetophenone
CAS No. 98-86-2
EPA Chen Code: 129033
Acifluorfen, sodfun
CAS No. 62476-59-9
EPA Ch«m Code: 121601
Not Likely
12 (CRAVE)
•2
0 (CRAVE)
0 (CRAVE)
62
Brain astrocytOMs; F344/CrL-Br rate (M)
Renal tubule cabined adenonas/carciriosm;
MC3F1 alee (N).
Renal transitional cell carcinomas; F344/N
rat* (F).
Hepatocetlular carclnoa**; CD-I arice (F)
I Nasal tuaors; SPF Wlstar rata (M ft F).
I Laryngeal tuaors; Syrian Golden hearten
I (M ft F).
Liver (MOTS; WUtar rate IB); F344 rata
(N ft F).
Natal eplthslius adenoe»ft. thyroid cell
adenoM. benign chondra of femur, basal
cell tuaor of stcnMch; CD rate (N ft F).
Pulswnsry adenoaws (M ft F); liver tusors
(M); CO-1 BJlea.
Liver; B6C3F1 ft CO-1 nice (M ft F).
Stomach paplUwmw; B6C3F1 nice (M ft F).
2.2 E-6 (I)
1.69 E-2
B2
Pend.
1.07E-1
B2/C
Clasetfication pending repeat of studies I
additional epfdenfological data.
[Syn. 2,4-Dichlorophenoxyacetic acid]
tSyn. OBCP, o-Benzyl-p-chlorophenol]
Studies were conducted usfng the free acid
fona of AC 263222. The PC Code C CASRH for
the anmonitn salt is 128943 t 104098-49-9.
respectively.
CRAVE Q* * B.7 E-3 (0).
This assessment is located on IRIS. OPP has
not reviewed this chariest.
AcetMtde (not itself a pettfclde) is a meta-
bolite of pesticides Nethomyl ft Thiodicarb.
AssessiRent based on lack of data concerning
csrcinogenlcity in humans or animals.
This atsessnent is located on IRIS. OPP has
not reviewed this chemical.
Assessment based on. lack of data concerning
csrcinogenlcity in humans or animals.
This assessment is located on IRIS. OPP has
not reviewed this chemical.
Pend. I Syn. Tackle ft Blazer
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DATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 2
CHEMICAL
CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY Q* I SAP I CRAVE
VALUE CLASS I CLASS
COMMENTS
Acrlrathrtn
CAS Ho. 101007-06-V
EPA Che» Code: 129141
Acrolefn
CAS No. 107-02-8
EPA Chew Code: 000701
Hery I amide
CAS No. 79-06-1
EPA Chem Code: 600008
Acrylonitcile
CAS No. 107-13-1
EPA Chen Code: 000601
Alechlor
CAS No. 15972-60-8
EPA Chem Code: 090501
Aldicarb (Temik)
CAS No. 116-06-3
EPA Che* Code: 098301
Aldrln
CAS No. 309-00-2
EPA Chem Code: 045101
Amlnopyridine, 4-
CAS No. 504-24-5
EPA Chen Code: 069203
Amltraz (Bam)
CAS No. 33089-61-1
EPA Chen Code: 106201
Amitrole
CAS No. 61-82-5
EPA Chem Code: 004401
B2 (CRAVE)
•1 (CRAVE)
Likely (high
doses)
Not likely
D (CRAVE)
B2 (CRAVE)
0 (CRAVE)
82
2B (IARC)
; Fischer 344
Adrenal cortical
rate (F).
Benign i/or malignant tutors at Multiple
•ite* in M * F rats (F344), i carcinogenic
effect* in a series of 1-year United blo-
btoasssys in alee (SENCAR. Swiss-ICR I A/J
strains) fay several routes of exposures.
Significant Increase in Incidence of lung
cancer In exposed workers t observation of
.tutors, generally astrocytosms In the
brain, in 2 rat strains exposed by various
routes (Mater, gavaga. inhalation).
Malignant A combined benign/malignant
•ultlpte tumr types in both sexes; Long
Evans rat
Significant trend In pituitary tusor; Fi44
rats (f). Signfleant trend in fibrosar-
B6C3F1 »lce (M).
Liver csrclnoMs; CJHeB/Fe Mice (N t F);
Hepatic hyperlasia I begnign hepatoMs;
C3H Bice (N * F); Hepatocellular carcin-
omas; B6C3F1 Mice (N).
Lynphoreticular tunors; CfLP mice (f);
Hepatocellular adenonas. carcinomas t
adenomas/earcinomBB combined; B6C3F1 «ice
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DATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: I
CHEMICAL
CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY 0* I SAP I CRAVE
VALUE I CLASS I CLASS
CONKENTS
Aniline
CAS No. 62-53-3
EPA Cham Cod*: 251400
Aramite
CAS No. 140-57-8
EPA ChM Code: 062501
82 (CRAVE)
82 (CRAVE)
CAS No. 3337-71-1
EPA. Chen Code: 106901
Atrazine
CAS Mo. 1912-24-9
EPA Cheat Code: 080803
Averiaecttn 81
CAS No. 65195-55-3
EPA Chen Code: 122804
Azinphoa-methyl (Guthlon)
CAS Ho. 86-50-0
EPA Cheat Code: 058001
Azobenzene
CAS No. 103-33-3
EPA Chew Code: 007401
Azoxyatrobfn
CAS No. 131860-33-8
EPA Chen Code: 128810
Berdac 22 (alao 2250, 2280)
CAS NO. 7173-51-5
EPA Chem Code: 069149
Baygon (Proponur)
CAS NO. 114-26-1
EPA Cheai Code: 047802
Befionyl
CAS No. 17804-35-2
EPA Cheat Code: 099101
C(q)
28 (IARC)
82 (CRAVE)
Not Likely
82
C(q)
Induction.of tumors of the spleen end the
body cavity In 2 etreim of rat 1CO-F A
riacher 344).
Liver tumora i/or neoplaatic nodule* In
3 atralna of N t f rata (FDRL, CFN (
Oeborne-Mendel) C M of one atrain of mice
.
Maasairy tuaora (flbroadenoma/edenocarelno-
•as); Spregue-Dauley rata (F).
5.7 E-3
2.5 E-2 (0)
7.1 E-6 (!)
82
82
2.22 E-1
Pend.
Invaalve aarcomaa In the apleen • other
abdaailnal organs; F344 rata (M & F).
1.1 E-1 (0)
3.1 E-5
82
Bladder careinomaa (rare), papillamas A
coafalned earcinona/papillom (NSF); Wiatar
rata. Statistically significant increases
in hepatocellular adenomas t combined ade-
naaa/carcinoM; 86C3F1 nice (M).
Liver tumors (hepatoceltular adenomas I
carcinoma) in 2 genetically related
strains of Mice (CO-1 * Swiss SPF) (M t, f\
3.69 E-3
4.2 E-3
Pend.
This assessment la located on IRIS, opp has
not reviewed thta chemical.
Thia assessment ia located on IRIS. OPP has
not reviewed thla chemical.
Repeat of rat carcinogenicity study is
requested.
Atobena ia genotoxic t may be converted to
benxldine, a known huaan carcinogen, under
the acidic conditions in the stomach.
Thia assessment ia located on IRIS. OPP ha
not reviewed this chemical.
MCPRC recommended the low dose extrapolation
model applied to the animal data be used for
the quantification of human risk (01*).
Benonyl rapidly hydrolyses to MBC in an
aqueous environment. MBC also appears to be
the Initial metabolite in mammalian systems.
MBC has similar or increased toniclty, both
acute t chronic, to Benonyl.
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DATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PACE: 4
CHEMICAL
OMREN1 Off
CLASSIFICATION
TIMOR TYPE / SPECIES
POTENCY Q*
VALUE
SAP
CLASS
CRAVE
CLASS
COMMENTS
Benoxacor
CAS No. 98730-04-2
EM Ottm Code:
Bentazon (Basagran)
CAS No. 25057-89-0
EPA ChM Code: 275200
Benzene
CAS No. 71-*3-2
EPA Chen Code: 008801
Benzole acid
CAS No. 65-85-0
EPA Chen Code: 009101
Blfenthrln (Talatar)
CAS No. 83657-04-3
EPA Che* Code! 128825
Biphenyl, 1.1-
CAS No. 92-52-4
EPA Chen Code: 017002
Bfm(chloroethyl)ether (BCEE)
CAS No. 111-14-4
EPA Chen Code: 029501
Borax
CAS No. 1303-96-4
EPA Che* Code: 011102
Boric acid
CAS No. 10043-35-3
EPA Chen Code: 011001
Boron
CAS No. 7440-42-8
EPA Cheat Code: 128945
BromacU
CAS No. 314-40-9
EPA Chen Code: 012301
Cannot be
determined,
but euggestlve
A (CRAVE)
0 (CRAVE)
D (CRAVE)
82 (CRAVE)
Increase* In glandular stomach (forestoav
acti) tuaora in both aexs of nice and rats;
CD-I Nice 4 Sprague-OaMley rate
Increased Incidence of nonlymphoeytle
leukemia fro* occupational exposure; Human
Increated Incidence of neoplesia in rata t
•Ice axpoaad by inhalation t gavage.
Hemenoioperfeytomes In the urinary bladder
Hepatocellular carcinomas i combinded
hepatocellular adenomas I carcinomas;
SMlaa Uebeter nice (N)
Increased evidence of hepatomas; (CS7B1/6
x C3H/Anf)M mice (M t F) and (C57B1/6 x
AKR)F1 Mica (N).
MCPRC reccmnended that for risk assessment
purposes, an MOE approach should be used
based on the most sensitive precursor stomach
lesion.
2.9 E-2 (0)
8.3 E-6 (I)
This assessment is located on IRIS.
not reviewed this chemical.
OPP has
Oef.
1.1 E+0 (0)
3.3 E-4 (I)
82
Assessment based on lack of data concerning
carcinogenicity in huaans ( inadequate animal
data. This assessment is located on IRIS.
OPP has not reviewed this chemical.
Assessment based on the tack data concerning
carcinogenic!ty in hums a inadequate animal
data. This assessatent is located on IRIS.
OPP has not reviewed this chemical.
This assessment is located on IRIS. OPP has
not reviewed this chemical.
[Syn. Dlehloroethyl ether)
Liver tunors (carcinomas t combined
adenomas/carcinomas); CD-I mice (*)•
Thyroid tuaora (C-cell adenomas I folllcu-
lar cell combined adenomas/carcinomas):
Crl:CO (BR) rats (H).
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DATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 5
CHEMICAL
CURRENT OPP
CLASSIFICATION
TIMOR TYPE / SPECIES
POTENCY
VALUE
SAP
CLASS
CRAVE
CLASS
COMMENTS
BromotrlehloroaNthane
CAS No. 75-62-7
EPA Chw Cod*: 008708
Bromoxyni I
CAS No. 1689-84-5
EPA Che* Codt: 035301
Bronuconaxole
CAS No. 116255-48-2
EPA Che* Code: 120503
Bronopol
CAS No. 52-51-7
EPA Che* Codt: 216400
Butylate (Sutan)
CAS No. 2008-41-5
EPA Chan Coda: MHOS
CaeodyUc acid
CAS No. 75-60-5
EPA Chem Coda: 012501
cadmium
CAS No. 74*0-43-9
EPA Che* Coda:
caduaa/oa (Ebufas/Rugby)
CAS No. 95465-99-9
EPA Che* Cade: 128864
Calcium cyanamide
CAS No. 156-62-7
EPA Che* Code: 014001
Captafol
CAS No. 2939-80-2
EPA Chem Code: 081701
Captan
CAS No. 133-06-2
EPA Chem Code: 081301
0 (CRAVE)
C(q)
B2
B1 (CRAVE)
1 (IMC)
C(q)
82
2A (IARC)
B2
Statistically tlgnificant increase* in
hepatoceUular adenoMs and/or carcinonaa
8 combined adenomas/carcinomas; CD-I *ice
(Hi F)
Urinary bladder tumor; Fischer 344 rats
(N I F). fibrosarcomae (Multiple organs);
B6C3F1 *ica (F).
limited evidence fro* occupational eptdaa-
iotooic studies. Evidence of carcinogen-
Icity in rats « *ice by inhalation t
intramuscular ( subcutaneous injection.
Ovarian grenulosa-thece tumors; CRL:CO-1
(ICR)BR mice (F) (Hydrogen cyanamide].
Positive trend in hemangiosarcomas; B6C3F1
mice (H) ICalcfum cyanamide]
Lymphosarcomas t hemangiosarcomas (H t F),
harderI an gland adenomas (H) CD-1 mice.
Nannary fibroadenoma (M t F), renal
adenomas/carcinomas (combined) (M)
Sprague-DBttley rats.
Renal cortical/tubular cell neoplasms;
CO rats (»); Uterine sarcomas; Utstar rats
(F). Intestinal tumors (H t F); B6C3F1,
ICR CD-I t CR CD-I mice.
Assessment based on tack of data concerning
carcinogenicity in hunans or animals.
This assessment is located on IRIS. OPP has
not reviewed this chemical.
1.03 E-1
4.1 E-1
6.23 E-2
1.8 E-3 (I)
B1
This assessment is located on IRIS.
not reviewed this chemical.
OPP ha»
6.74 E-2
5.1 E-2
2.4 E-3
Calcium cyanamide is rapidly t quantitatively
converted to Hydrogen cyanamide in solution t
at the pH of the human t rodent gut. Thus.
Calcium cyanamide studies were used as
supporting data for Hydrogen cyanamide.
B2
Pend.
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DATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 6
CHEMICAL
CURRENT OPP
CLASSIFICATION
TUMOR TVPE / SPECIES
POTENCY 4* I SAP I CRAVE
VALUE CUSS I CLASS
COMMENTS
Carbaryl
CAS NO. 63-25-2
EPA Chea Code: 056401
Carbon tetrachloride
CAS No. 56-23-5
EPA Che* Code: 016501
ChlorMtoen
CAS No. 133-90-4
EPA Chea Code: 029901
Chlordane
CAS No. 57-74-9
EPA Chea Code: 058201
ChlordfMfor*
CAS No. 6164-98-3
EPA Chea Cod*: 059701
Chlorfenapyr (Pirate)
CAS No. 122453-70-0
EPA Chea Code: 129093
CttloroanUtne, p-
CAS No. 106-47-8
EPA Chea Code: 017203
Chlorobenzene
CAS No. 108-90-7
EPA Che* Code: 056504
Chlorobeniilate
CAS No. 510-15-6
EPA Chem Code: 028801
Chlorofora
CAS No. 97-66-3
EPA Chen Code: 020701
C(tj)
K (CRAVE)
Deferred
82 (CRAVE)
2B (IARC)
B2
3 (IARC)
Cannot Be
Oeterained
Suggestive
B2
2B (IARC)
0 (CRAVE)
B2 (CRAVE)
Heaangfoaarcoaaa (Ml(grant vascular tut-
ors) t coablned heaangloMs/heaangiosar-
CRL;CT-1 (ICR)BR Mice (N).
Napatocellur carcinomas; Oaborne-Mendel,
Japanese i Wlstar rats; 86C3F1. CJN, A, »,
C and L mice; Syrian golden hauler*
Benign t malignant liver tuaors; CS7B1/6N,
CD-I, B6C3F1 A ICR aiice (M I F); F344 rats
Malignant haaangtoendotheloaas; Tlf:MAG:
SPF alee (M t F)
The overall evidence In anlaala Has not
perauasuve. but could not be diMissed.
Increase In tutors In rats occurred Mfth
significant positive trends only, and
aainly at the highest dose.
Spleen (f ibrosarcoaas, heaangiosarconas 1
osteossrcoaas) (M); Adrenal (pheochroaocy-
toaas) (MiF); F344/N rats. Hepatocellular
adenomas/carcinomas (M); Nenangiosarcoais
in spleen (/or Uver (M); B6C3F1 alee
Kidney tuaars; Osborne-Hendet rats (M).
Hepatocellular carcinomas; B6C3F1 alee
(H ft F); Hepatomas; A and NLC strain alee
(F).
2.27 E-2
1.3 E-t (0)
1.5 E-5 (I)
B2
1.3 E+0 (0)
3.7 E-4 (I)
1.3 (diet)
9.4 E-1
B2
6.38 E-2
6.1 E-3
2.3 E-5
(0)
(I)
B2
Carbaryl also induced tinurs at multiple
organ sites in alee t rats but at dose level*
considered to be excessively toxic for
carcinogen!city testing.
This assessment is located on IRIS.
not reviewed this cheaical.
OPP has
HCPRC requested reviewer to re-tabulate data
for both NCI studies; including data for
pooled controls £ results of the data audit;
historical controls are also required. Rerev-
iew 1979 rat study ft 1978 mouse study.
Chlordane is structurally related to other
known liver carcinogens.
This assessment is located on IRIS. OPP has
not reviewed this cheaical.
Timor was observed in 3 studies - Chlordiraef-
or* i its two aetabolites {N-formyl-4 chloro-
o-toluidine t 5-CAT].
0* of 9.4 E-1 is for occtaiational.
p-Chloroaniline is a aetabolite of DinMin.
Assessment Is based on lack of hunan data.
inadequate animal data t predominantly negat-
ive genetic toxicity data. This assessment
is located on IRIS. OPP has not reviewed
this chemical.
This assessment is located on IRIS.
not reviewed this chemical.
OPP has
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DATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 7
CHEMICAL
Chlorothalonil
CAS No. 1897-45-6
EPA Chm Cod*: 081901
CURRENT OPP
CLASSIFICATION
Likely
3 CIARC)
TUMOR TYPE / SPECIES
Renal adenomas i carcinomas, both tenet of
rats i ale*; rarity of the tuaor reipome
In the kidney; papl llamas I/or carcinomas
of the forestomech In rats t mice; CD-I
•fee; Ftachar 344 * Osborne-Mendel ratt
POTENCY B*
VALUE
7.7 E-3
SAP
CLASS
Defer.
CRAVE
CUSS
Pend.
COMHENTS
HCPRC recoanended that a non- linear appraoch
to ri«k assessment, using HOC. should be
uted.
Chlorpropha* (CIPC)
CAS No. 101-21-3
EPA Ch«« Code: 018301
Chlorpyrifos
CAS No. 2921-88-2
EPA Chwa Code: 059101
Cinch (C1 methyl In)
CAS No. B781B-31-3
EPA Che* Code: 128837
Clofenteiine >«- Code: 036501
Creosote
CAS No. 8001-58-9
EPA Chea Code: 025004
Cresol, p-Chloro-m-
CAS No. 59-50-7
EPA Chen Code: 064206
Cryolite (Kryoclde)
CAS No. 15096-52-3
EPA Chem Code: 075101
Cyanarine (Bladex)
CAS No. 21725-46-2
EPA Chen Code: 100101
Thryroid follicular cell adenoma/carcinoma
Sprague-Dawley rat YH).
D (CRAVE)
HCPRC concluded there was no sifcstantial bio-
logical evidence of tumor formation in mice
or rats, however, dosing in both studies were
inadequate for determining carcinogenic pot-
ential. Additional studies are requested.
Assessment based on tack of human data t
inadequate animal data from assays of copper
compounds. This assessment is located on
IRIS. OPP has not reviewed this chemical.
Bl (CRAVE)
Limited evidence of the association betwe-
en occupational creosote contact t subsqu-
ent tuaor formation, sufficient evidence
of local t distant tutor formation after
denttl application to nice.
Bl
This assessment is located on IRIS.
not reviewed this chemical.
OPP ha.
C(q)
Mammary gland tuwrs (adenocarclnoma,
carctnosarcoBia); Sprague-DaNely rat
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Off ICE Of PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 8
CHEMICAL
CURRENT OPf»
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY Q*
VALUE
SAP
CLASS
CRAVE
CLASS
COMMENTS
cycUnitfde
CAS No. 11J136-77-9
EPA Chen Coda: 026201
Cyhalothrln/Karate
CAS No. 68085-65-8
EPA Chen Code: 12886?
Cypenwthrin
CAS Ho. 52515-07-8
EPA Chen Code: 109702
Cyproconazole'(SAN 619F)
CAS No. 9*361-06-5
EPA Chen Code: 128993
Cyronazlne (Larvadex)
CAS Ho. 6621S-27-8
EPA Chen Code: 121301
ODD
CAS No. 72-54-8
EPA Chen Code: 029101
ODE
CAS No. 72-55-9
EPA Chen Codet
DDT
CAS No. 50-29-3
EPA Chen Code: 029201
DEET
CAS No. 134-62-3
EPA Chen Code: 080301
Dacthal (DCPA)
CAS Ho. 1861-32-1
EPA Chem Code: 078701
Not Likely
•2
B2 (CRAVE)
28 (IARC)
B2 (CRAVE)
28 (IARC)
B2 (CRAVE)
2B (IARC)
C(q>
Benign lung adenonn (increase in both
adenoiM ft adenonas/carcinonas combined);
Alderly Park SPF Suite strain Mice (F)
Hepatocellular adenoMs t carcinoiaas; CO-1
•ice (H I f>.
3.02 E-1
Lung tuaors (N ft F). liver tinori (M);
CF-1 «lc«. Thyroid tunort (folltcular
cell adenoma t carcinomas); Osborne-
Mendel raU (N).
Liver tumrs; B6CJF1 mice (hepatocellular
carcinoma) (H ft F); CF-1 nice (hepatons)
(N t F). Liver (neoplastice nodule*);
Syrian Co I dm Hamsters (M ft F). Thyroid
tutors; Osborne-Nendel rats (F).
Tuaora (generally of the Uver) were obse-
rved in 7 studies In various wouse strains
[BALB/C, CF-1, A strain, Suiss/Boneby ft
(C57Bt)K(C3HxAkR)l ft^in 3 rat studies
(Ui»tar, HRC Porton * Osborne-Hendel).
Thyroid tunors (N-ft F); Mepatocellular
BdenomB/carclnoma/hepatocholoangiocarcin-
oma
-------
ATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PACE: 9
CHEMICAL
CURRENT OPP
CLASSIFICATION
TIMOR TYPE / SPECIES
POTEHCT 0*
VALUE
SAP
CLASS
CRAVE
CLASS
COMMENTS
amlnozlde (Alar)
CAS No. 1596-84-5
EPA Choi Code: 035101
CAS No. 533-74-4
EPA Chem Code: 035602
lesmedipham
CAS No. 13684-56-5
EPA Cheat Code: 104801
>i (2-ethylhenyl )phthalat«
CAS No. 117-81-7
EPA Chem-Code: 295200
tiazlnon
CAS No. 333-41-5
EPA Chan Code: 057801
Hbromochloropropane (DBCP)
CAS No. 96-12-8
EPA Chem Code: 011301
>ibronoethane, 1,2-
CAS No. 106-93-4
EPA Chem Code: 042004
libutyl phthalate
CAS No. 84-74-2
EPA Chem Code: 028001
oicamba
CAS No. 1918-00-9
EPA Chen Code: 029801
oiehlobentl
CAS No. 1194-65-6
EPA Chem Code: 027401
lichlorobenzamide, 2,6-
CAS No. 2008-88-4
EPA Chen Code: 027402
B2 (CRAVE)
Not Likely
B2 (CAG)
28 IIARC)
B2 (CRAVE)
D (CRAVE)
Unclasstfiable
Multiple sites
-------
OA1E: 05/27/98
Oftlf£ OF PESTICIDE PROGRAMS LIST Of CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 10
CHEMICAL
CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY Q*
VALUE
SAP
CLASS
CRAVE
CLASS
COMMENTS
Olchlorobenient, t.2- 0 (CRAVE)
CAS Ho. 95-50-1
EPA Cham Code: 059401
Dlchloroethane, 1,2- §2 (CRAVE)
CAS No. 107-06-2
EPA Che* Code: 042003
Olchloroethylene. 1.1- I C (CRAVE)
CAS No. 75-35-4 I
EPA Che* Code: 600033 |
Dfchloromethane 82 (CRAVE)
CAS Mo. 75-09-2
EPA Che» Code: 042004
Dichloropropene. 1,3- B2
CAS No. 542-75-6
EPA Che* Code: 029001
Dlchlorvos (DDVP) «q)
CAS No. 62-73-7 2B (1ARC)
EPA ChM Code: 084001
0 I clof op-methyl (Hoelon) C(q)
CAS No. 51338-27-3
EPA Chen Code: 110902
Dfcofot (Kelthane) I C
CAS No. 115-32-2 3 (IARC)
EPA Ctie».Code: 010501 |
Oieldrln "2 «**VE)
CAS Ho. 60-57-1
EPA Chen Code: 045001
Dlethyl phthalate 0 (CRAVE)
CAS No. 84-66-2
EPA Chen Code: 128947
Induction of several tutor types in rate
0*borne-Mendel rats ft 86C3F1 Mice treated
by gavage and lung papflloens in 1CR/HA
Swiai Mice after topical application.
Kidney adenomacarcinoma; Swiss mice (M)
Hepatocellular neoplasms t alveolar/bron-
chi otar neoplasma; B6C3F1 mice (M ft F).
Benign mammary tumors (M & F), salivary
gland sarcomas (N). leukemia (F); F344
rat*.
Forestomaeh, liver, mammary, thyroid.
adrenal, urinary t lung tumors; FUcher
344 rat* ft B6C3F1 mice (N ft F).
Bronchioloaveoler adenoM*; B6C3F1 eiice
(M).
Stonach tumor* (forestonach. papillona
squamous, t squammis cell carcinoma);
B6C3F1 Mice; (F). Leukemia (of all sites
ft types); Fischer 344 rata (M).
Significantly increased (palraise ft trend)
hepatocellular adenomas. carcinomas >
combined tumors; HOE NMRKf (SPF 71) Mice
(N ft F).
Liver tvmora (adeno«as/c.arcinom>; B6C3F1
•ice (M)
Effects range front benign Hver tunors to
hepatocarcinomas with transplantation con-
firmation, to pulawnary netastases; M ft F
nice (C3HeB/Fe. C3H. CF1. B6C3F1. C3H/ME ft
C5TB1/6J)
9.1 E-2 (0)
2.6 E-5 (I)
6.0 E-1 (0)
5.0 E-S (I)
7.5 E-3 (0)
4.7 E-7 (I)
S.33E-2 (I)
1.22 E-1
2.3 E-1
B2
82
82
B2
1.6 E*1 (0)
4.6 E-3 (1)
Oef.
B2
Aaseasawnt based on lack of data concerning
carcinogenic!ty in tunans ft inadequate animal
data. This assessment is located on IRIS.
OPP has not reviewed this cheaical.
(Syn. Orthodichiorobenzene]
This assesaaent is located on IRIS.
not reviewed this ehearicat.
(Syn. EDO
OPP has
This assessment is located on IRIS. OPP has
not reviewed this chemical.
[Syn. Vinylidene chloride)
This assessment is located on IRIS.
not reviewed this chemical.
[Syn. Telon* II)
CRAVE 0* - 2.9 E-1 (0).
OPP has
This assessment Is located on IRIS.
not reviewed, this chemical.
OPP has
Assessment based on lack of data concerning
carcinogenicity in huaans or »n'"»ls-
This assessment is located on IRIS. OPP has
not reviewed this chemical.
-------
)AlEt 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 11
CHEMICAL
CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY 0*
VALUE
SAP
CLASS
CRAVE
CLASS
COMMENTS
Hfenoconazole (Oividtnd)
CAS Ho. 119446-68-3
EPA Chem Code: 1288*7
Hfenzoquat methyl aulfat*
CAS No. 43222-48-6
EPA ChM Code: 106401
Hflubenturon (Dimllln)
CAS Ho. 35367-38-5
EPA Che* Code: 108201
Hmethenanid (SAN 5B2H)
CAS He. 87674-68-8
EPA ChM Code: 129051
>iMthipin (Harvade)
CAS No. 55290-64-7
EPA Chem Code: 118901
)imethoate
CAS No. 60-51-5
EPA Chen Code: 035001
31methyl ether
CAS No.
EPA Chen Code:
Jimethyl phthaUte
CAS No. 131-11-3
EPA Chew Code: 028002
Jinocap (Kara thane)
CAS No. 39300-45-3
EPA Cheat Code: 036001
Dinoseto
CAS No. 88-85-7
EPA Chen Code: 037505
aiphenylamine
CAS No. 122-39-4
EPA Chen Code: 038501
D (CRAVE)
Not Likely
Statlatically aignlftcant Increases in
liver adenoMS, carcinomas t combined
adenomas/carcinomas; CD-I mica (N I F).
Statlatically significant increasing trend
for benign combined */or malignant liver
tuaora; Sprague-Oanley rat (M). Unresolv-
ed Usuas regarding nasal tuaors. strong
autagenicity data A SAR.
Tentative C I Lung adenoMa I carcinoMs; CD-I mice (N)
Hemolymphoretlcular tuaora; B6C3F1 mice
. Spleen (heaMngieaia t he*angiosarcoM>
akin (heawgloaarcoM), ly^ (anglona I
angiosafcoav) tuaora; Uiatar rats (N).
Liver adenoma; CO-1 mice (F).
Classification supported by animal metabo-
lism studies and open literature data that
indicate there was no evidence that the N-
nitroso metabolite of diphenylamlne would
be formed in rat or hunans in vivo.
Tuaora were observed at doses whfch were
considered to be excessively high for carcin-
ogen! city testing.
p-Chloroaniline is a metabolite.
HCPftC recommended a heritable translation
test, which is the nent required test after a
positive dominant lethal study
-------
DATE: 05/27/98
OFFICE Of PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PACE: 12
CHEMICAL
CURRENT OPP
CLASSIFICATION
TIMOR TYPE / SPECIES
POTENCY 0* | SAP I CRAVE
VALUE I CLASS CLASS
COMMENTS
Diquat dibromtde
CAS No. 85-00-7
EPA Chem Code: 032201
DUutfoton (Disyston)
CAS No. 298-04-4
EPA Chen Code: 032501
Dlthiopyr (MON 7200)
CAS No. 97886-45-8
EPA Chem Code: 128994
Dfuron
CAS No. 330-54-1
EPA Chem Code: 035SOS
Endosulfan
CAS No. 115-29-7
EPA Chen Code: 079401
Endrln
CAS Ho. 72-20-8
EPA Chew Code: 041601
Epichlorohydrln
CAS No. 106-89-8
EPA Chen Code: 097201
Esfenvalerate (Asna)
CAS No. 66230-04-4
EPA Che* Code: 109303
Ethalfluralin (Sonalan)
CAS No. 55283-68-6
EPA Chen Code: 113101
Ethephoo
CAS No. 16672-87-0
EPA Chem Code: 099801
Cthion
CAS No. 563-12-2
EPA Chem Code: 058401
Known/Likely
D (CRAVE)
82 (CRAVE)
C(q)
Pend.
Urinary bladder carcinomas; Uistar rat (M
1 ft. Mammary gland carcinomas; NMRI mice
(F). Information fron structurally related
analogs provided further support.
An NCI bioassay Mas suggestive of response
in Osborne-Nendal rats (M i F).
Multiple studies in rats t nice administ-
ered eplchlorohydrln by various routes
were positive. As epichlorotiydrin Is a
strong alkylating agent, tumors are prod-
uced at the site of application.
Mammry tuaors (F); Suggestion of bladder
tutors (F) and kidney tumors (f t F);
Fischer 344 rats
Def.
9.9 E-3 (0)
1.2 E-6 (1)
8.9 E-2
For the purpose of risk characterization, a
low dose linear extrapolation model be appl-
ied to the animal data for the quantification
of human risk, based on urinary bladder car-
cinomas in the male rat.
This assessment is located on IRIS. OPP has
not reviewed this chemical.
This assessment is located on IRIS. OPP has
not reviewed this chemical.
Data from Fenvalerate (CAS No.
was used In this assessment.
51630-58-1)
HCPRC considered the dose levels in the mouse
study to be Inadequate; however HCPRC did
not recommend repeating the study.
The RFOC considered that the evidence from
the 2 rat studies t 1 of the mouse studies to
be inadequate to support a positive carcino-
gentctty finding, while the evidence from the
other mouse study was equivocal.
-------
DATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 13
CHEMICAL
CURRENT OPP
CLASSIFICATION
TIMOR TYPE / SPECIES
POTENCY Q* I SAP I CRAVE
VALUE CLASS I CLASS
COMMENTS
EtMoxtn (Ebuzin/Tycor) | Tentative C
CAS No. 64529-56-2
EPA ChM Code: 128883
Ethofenprox (Etofenprox) I C(q)
CAS Ho. 80844-07-t I
EPA Che* Code: 128965
Ethofumesate
CAS No. 26225-79-6
EPA Che* Code: 110601
Ethoprop (Ethoprophoe) Likely
CAS No. 13194-48-4
EPA Chew Code: 041101
Ethylene I 3 (IARC)
CAS No. 74-85-1
EPA Che* Code: 041901 |
Ethylene diemine 0 (CRAVE)
CAS No. 107-15-3
EPA Che* Code: 004205
Ethylene dibromtde (EDI) B2 CCAG]
CAS No. 106-93-4 2A (IARC)
EPA Che* Code: 042002
Ethylene oxide I t (IARC)
CAS No. 75-21-8 I
EPA Che* Code: 042301 |
Ethylene thiourea (ETU) 82
CAS No. 96-45-7
EPA Chen Code: 600016
Fenaniphos (Neaueur)
CAS No. 22224-92-6
EPA Chew Code: 100601
Fenarinol
CAS No. 60168-88-9
EPA Chen Code: 206600
Thyroid follicular cell tuners; F344 rate
(N ft F>
Combined thyroid follicular cell adenoma*/ I 5.1 E-3
carcinomas; Sprague-Dawley rata (N A F). I
Pheochromocytoma - .adrenal glands (aallgn-
nant); .Sprague-Dawley rat (H>; Cell carc-
inoma* - thyroid gland; Sprague-OaMley t
Fiecher 344 rat (M); Evidence of clasto-
genlclty in vitro tutagenicity testing
Foreatomach (aquamoua cell carcinomas)
(N * F) Otbome-Mendet rata t B6C3F1 Mice.
Alveplar/bronchiolar adenoma (HtF) nice.
Kemengtosarcomas (circulatory ayate*) ft
hepatocellutar carcinoma* (N) rata.
Thyroid adeneaw, carcinoma, ft coabined
adenoM/carclnoM; F344 ft CRCO rata (NtF).
Thyroid ademxaaa ft carcinona, putultary t
liver tuaore; B6C3F1 t C57BL/6 x AKR nice
(N ft F).
2.81 E-2
67
1.4
(0)
(»
6.0 E-2
B2
Pent).
Quantification deferred pending submission t
evaluation of additional data.
Assessment based on the fact that the carcin-
ogen! city phase of the rat study t the
heanter study were both considered to be
inadequate.
A linear low-dose approach for hunan risk
characterization t extrapolation should be
baaed on malignant pheoehromocytoims of the
adrenal glands in male rats at all dose
levela tested.
Assessment based on Uck of data concerning
carcinogenic)ty in humans or animals.
This assessment is located on IRIS. OPP has
not reviewed this chemical.
-------
DATE: OS/27/98
OFFICE OF PESTICIDE PROGRAMS LIST Of CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PACE: H
CHEHICAL
CURRENT OPP
CLASSIFICATION
TIMOR TYPE / SPECIES
POTENCY a*
VALUE
SAP
CLASS
CRAVE
CLASS
COMMENTS
Fenbuconaxol* (Fwwttimll)
CAS Ho. 114369-43-6
EPA Choi Code: 129011
Fenbutatln oxide (Vendex)
CAS No. 13356-08-6
EPA Che* Code: 104601
Fenftrothion ; CO-1 aiice
1.06 E-2
B2
Lung adenoMS, carcinomas ft combined
adenow/carclnona; Harder I an 4! and
adenoMt; CD-I «ice
-------
DATE: OS/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: IS
CHEMICAL
CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY Q* I SAP I CRAVE
VALUE I CLASS I CUSS
COMMENTS
FluaJelorac pent yI
CAS No. 875*6-18-7
EPA Chem Code: 128724
Fluometuron
CAS No. 2164-17-2
EPA Chen Code: 035503
Fluridone
CAS No. 59756-60-4
EPA Che* Code: 112900
Fluroxvpyr (DOUCO 433)
CAS No. 69377-81-7
EPA Chem Code:
Flusiluol* (Hustar)
CAS No. 85509-19-9
EPA Che* Code: 128835
Mutolanil (Honcut)
CAS No. 66332-96-5
EPA Che* Code: 128975
Folpet
CAS No. 133-07-3
EPA Chew Code: 081601
fomesafen (Flex)
CAS No. 72128-02-0
EPA Che* Code: 123802
Fonofos (Dyfonate)
CAS No. 944-22-9
EPA Che* Code: 041701
formaldehyde
CAS Ho. 50-00-0
EPA Chew Code: 043001
Formetanate hydrochlorlde
CAS No. 23422-53-9
EPA Chem Code: 097301
Fosetyl-At (Allette)
CAS No. 39148-24-8
EPA Chem Code: 123301
Not Likely
Deferred
•2
C(q)
81 (CRAVE)
Unclassified
Statistically significant increases in
combined adenomas/carcinomas of the lung
-------
JATE: OS/27/98
Off ICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 16
CHEMICAL
.CURRENT OPP
CLASSIFICATION
TUMOR TYPE /
SPECIES
POTENCt 0*
VALUE
SAP ' 1
CLASS -
CRAVE I
CLASS I
COMMENTS
FunMcycloM (Xylloen I) I BZ
CAS No. 60568-05-0
EPA Che* Code: 122601 |
Glyphosate I E
CAS No. 1071-83-6 . I
EPA Cheat Code: 417300 |
Glyphosate tr.imesiua IE
CAS Ho. 51591-81-3
EPA Chen Code: 128501 |
Halosulfuron-methyl I E
CAS No. 100784-20-1
EPA Che» Code: 128721 |
Haloxyfop-methyl (Verdict) B2
CAS No. 690806-40-2
EPA Cheat Code: 12S20I
Heptachlor - I e2 (C**WE)
CAS No. 76-44-8
EPA Che* Code: 044801 |
Heptachlor epcxlde . ' I B2 (CRAVE)
CAS No. 1024-57-3
EPA Che* Code: 044801 |
Hexachlorobenzena (HCB) I B2 (CRAVE)
CAS No. 118-74-1 I 28 (IARC)
EPA Che* Coder 061001
Hexachlorocyclohaxane B2 (CRAVE)
CAS No. 608-73-1
EPA Chen Code: 008901
Hexaehlorocyclopentadierie, ' ft (CRAVE)
CAS No. 77-47-4
EPA Chen Code: 027502
Hexachloroethane C (CRAVE)
CAS No. 67-72-1
EPA Chem Code: 045201
Hexaconaiole (Anvil) «q)
CAS No. 79983-71-4
EPA Chem Code: 128925
Liver tutor* (M ft F); Urothellal tuaora
(M); Sprague-Oawley rats
2.98 E-2
B2
Liver tumors (adenomas (M). carcinomas (F)
ft adenomas/carcinomas (N ft F)l; B6C3F1
srfce.
7.39 E-0
Int. C
Pend.
Benign and amlignant -H«r tuwors (M * F) I 4.5 E+0 (0) j I B2
in Bice (CM ft B6C3F.1) 1-» *'* <»>
Liver earelnoa«»; C3H ft CO-1 «1e« (M ft F); I 9.1 E*0 (0) I I
CFN rata (F). 2.6 E-3 (I)
Tuaora In the liver, thyroid t ki*ey «" M-f f*» <°>
rata (Sprague-OaWley. Aflus * Mlatar). alee 4.6 E-4 (I)
(SNlaa I ICR) and haoatera (Syrian. Golden) |
Benign hepatic nodules» hepatocellular
carclnoaaa; Swiaa «fce (M). Liver nodule*
hepatoma; dd a>ic« (N * F). Hepatomaa;
ICR-JCL «lc« (M ft F).
Hepatoeellular carcinoma; B6C3F1 wlce
(Mi F).
Benign Leydig cell timers; Uiatar (Alpk:
APfSO) rat (M)
1.8 E+0 (0)
5.1 E-4 (I)
B2
62
1.4 E-2 (0)
4.0 E-6 (I)
2.3 E-2
CRAVE 0* -3.0 E-2 (0).
[Syn. Sulfosate)
Aaaeasecht also based upon the acknouledge-
aent by the registrant.that the compoond
would be likely to cause tunors of the liver
In rata If tested at adequate dosage levels.
This assessment is located on IRIS. OPP has
not.reviewed this chemical.
Hexachtorobenzene is a contaminate of PCNB C
Dacthal. OPP has revised (06/21/95) the oral
Q* for HCB: 1.02 E+0.
This assessment is located on IRIS.
not reviewed this chemical.
Cfiyn. t-HCjtJ
OPP has
Assessnent based on inadequate data in htmans
t no data In animals concerning earcinogenic-
ity. This assessment ia located on IRIS. OPP
has not reviewed this chemical.
This assessment is located on IRIS.
not reviewed this chemical.
OPP has
Chemical was not adequately tested for
carcinogenic potential in mice. Repeat of
study not required at this tine.
-------
DATE: OS/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 17
CHEMICAL
(CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY Q*
VALUE
SAP
CRAVE
CLASS CLASS
COMMENTS
Hexsxlnone
CAS No. 51235-04"-2
EPA Che* Code: 107201
Hexythiazox (Savey)
CAS No. 78587-05-0
EPA Chan Code: 128849
Hydra** thyInon (Amdro)
CAS No. 67485-29-4 *
EPA Chen Code: 118401
Hydrogen cyanamide
CAS No. 420-04-2
EPA Chen Code: 014002
Kydroprene (Altoiar)
CAS No. 41096-46-2
EPA Chen Code: 486300
Hydroquinone
CAS No. 125-31-9
EPA Che* Code:
Inazalll
CAS No. 35554-44-0
EPA Chen Code: 111901
Imazapyr (Arsenal)
CAS No. 81334-34-1
EPA Che* Code: 128821
Imazethabenz (Assert)
CAS No. 81405-85-8
EPA Chen Code: 128843
Imldacloprid
GAS No. 105827-78-9
EPA Chew Code: 129099
Iprodiore (Glyeophene)
CAS No. 36734-19-7
EPA Chew Code: 109801
C(q)
C(q)
Not classified
C(q)
Likely
Statistically significant increasing trend
In combined hepetocellular adenoma/careIri-
OM; CO-1 nice (F)
Liver (hspatocellular carcinomas t
carcinomas/adenomas combined); B6C3F1 mice
Lung adenomas ft combined adenomas/care fno-
CO-1 ale* (F).
2.22 E-2
Pend.
Ovarian granulosa-theca tumors; CRL:CD-1
(ICt)IR •<» (F) (Hydrogen cyanamidel.
Positive trend in hemangiosarcomas; B6C3F1
Mice (M) [Calciuacyana«ide].
6.74 E-2
Hepatocellular adenonas t coofcinedadenom-
as/carclnosMS u/positlve trends for adeno-
M*. carcfnoMS & cosfatned adenomas/carc-
innaas (M); Liver tours (adenomas i cew-
bined adenoMS/earclnoams) (F>; Suiss site*
Vascular; Positive trend for henangiosar-
comas in CD-I Mice (M).
5.6 E-2
6.2 E-2
Def.
Liver adenomas, carcinomas t confcined
adenomas I/or carcinomas (M t F); Ovarian
luteomas (F); Crl:CO-1 mice. Testlcular
interstitial cell benign tumors;
Crl:CO(SQ)BR rats (M).
4.39 E-2.
AssessMent based on evidence that u»s equivo-
cal (not entirely negative, but yet not con-
vincing) since only statistically significant
increase MSB in F nice (by trend test, but
not by pairuUe coaparlson with controls).
Calciua cyanamide is rapidly t quantitatively
converted to Hydrogen cyanamide in solution t
at the pH of the hunan t rat gut. Thus,
Calciua cyanamide studies were used as
supporting data for Hydrogen cyanamide.
Assessment based on equivocal nature of the
findings In the rat study and the lack of a
carcinogenicity study in a second specie*.
Hydroquinone .is a plant metabolite of Asulam
HCPRC concluded that another rat study
conducted at adequately high doses, an in
vivo UOS study and an S-Phase cell prolifer-
ation assay.
-------
DATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOX CARCINOGENIC POTENTIAL
PAGE: 18
CHEMICAL
' CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY 0* I SAP
VALUE I CLASS
CRAVE
CLASS
COMMENTS
laophorone -
CAS No. 78-59-1
EPA Che* Cod*: 047401
lioxaben IEL-107)
CAS No. 82558-50-7
EPA Che* Code: 125851
Isoxaflutole
CAS No. 14112-29-0
EPA Chea Code: 123000
Kathon 886 (Kathon Biocide)
CAS No. 55965-84-9
EPA Chen Code: 107106
Lactofeh (Cobra).
CAS Ho. 77501-63-4
EPA Chen Code: 128888
Llndane
CAS NO. 58-89-9
EPA Chea Code: 009001
Llnuron
CAS No. 330-55-2
- EPA Che* Code: 035506
NBC
CAS No.
EPA Chen
Code:
HOC Repellent 326
CAS No. 136-45-8
EPA Chen Code: 047201
MGK-264
CAS NO. 113-48-4
EPA Chen Code: 057001
C(q)
B2
C (CRAVE) | Preputtal gland carcinomas;-F344/N rate
(M).
Nepatocetluiar adenoMs; B6C3M nice (HAF)
Likely Statistically significant increases in
liver tumor* In both sexes of mice A rata;
statistically significant increases in
thyroid tumors In Ml* rats; CD-I nice A
Sprague-OaMley rata
B2 Nepatocelluar carcinomas (N); Hepatocell-
uar adenomas A carcinomas (N A F); CD-I
•Ice. Liver neoplastlc nodules; Sprague-
Dawely rata (N A F),
B2/C (CAG) I Liver and lung tumors (both gehlgn); nice
Testfcular tumors; CD rats (N); Hepatocel-
luar adenonas; CD-I nice
Statistically significant increases for
thyroid folllcular cell adenomas; Crl:CDBR
rats (M).
Pend.
1.7E-1
4.2 E-3
2.4 £-3 (M)
1.2 E-3 (F)
This assessment is located on IRIS. OPP has
not reviewed this chemical.
For the purpose of risk characterization, a
non-linear approach.- HOE be applied to the
east sensitive precursor lesion in M rat thy-
roid, C that a linear low-dose extrapolation
be applied for the tumors of the rat liver.
Assessment based on the lack of second car-
clnogeniclty study in a another species.
A Llndane metabolite, 2,4,6-trichlorophenol
(TCP) is classified as B2.
Benomyl rapidly hydrolyses to HSC in an
aqueous environment. MBC also appears to be
the Initial metabolite in manmalian systems.
MBC has similar or increased toxicity, both
acute t chronic, .to Bencmyl.
-------
DATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 19
CHEMICAL
IfURRENT OPf
CLASSIFICATION
.TUMOR TWE / SPECIES
POTENCY 0*
VALUE
SAP
CLASS
CRAVE
CLASS
COMMENTS
MOH 21200 (Genesis)
CAS No. 02697-71-0
EPA ChM Cod*: 128726
Halethion
CAS No. 121-75-5
EPA ChM Code: 057701
Maletc hydratide
CAS No. 5716-15-4
EPA Che* Code: 051502
Maneozeb
CAS No. 8018-01-7
EPA ChM Code: 014504
.Maneb
CAS No. 12427-58-2
EPA ChM Code: 014505
MelMtne
CAS No. 108-78-1
EPA ChM Code:
Hepfquat chloride
CAS No. 24307-26-4
EPAThM Code: 109101
MereeptobenzotMazole, 2-
CAS Mo. 149-30-4
EPA ChM Code: 051701
Mercury (Inorganic)
CAS No. 7439-97-6
EPA ChM Code: 052301
Metalanyl
CAS No. 57837-19-1
EPA ChM Code: 113501
Hetan sodlun
CAS No. 137-42-8
EPA ChM Code: 039003
D
3 (IARC)
B2
BZ
N/A
0 (CRAVE)
B2
Statistically significant Increase in
histlocytfc sarcMSS (F); CD-I atce
Thyroid C-Call
i; F344 rat (N * F).
Thyroid foilIcular cell adenoaws t earcin-
paaa. cMbtned thyroid folticular cell
•denoMS I/or carcinoMs; Crl:CO(BR) rats
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DATS: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST Of CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 20
CHEMICAL
1 CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY a* | SAP I CRAVE
VALUE I CLASS CLASS
COMMENTS
Methemidopho* (Monitor)
CAS No. 10265-92-6
EPA Che» Cod*: 101201
Methane •r.onlc Kid CNAA)
CAS No. 124-58-3
EPA ChM Code: 128876
Methidathlon
CAS No. 950-37-8
EPA Chen Code: 100301
Methlocarb (Mesurol)
CAS No. 2032-65-7
EPA Che* Code: 100501
Methomyl ««
CAS No. 16752-77-5 I
EPA Ch«M Code: 090301 |
Methoxychlor 0 (CRAVE)
CAS No. 72-0-5 3 (IARC)
EPA Che* Code: 034001
Methyl bromide 0 (CRAVE)
CAS No. 74-83-9
EPA Ch«i Code: 053201
Methyl ethyl ketone (MEK) 0 (CRAVE)
CAS No. 78-93-3
EPA Che* Code: 044103
Me thy I en* bU(thlocyanate)
CAS No. 6317-18-6
EPA Chn code: 068102
Methylphenol, 3- !.« (CRAVE)
CAS NO. 108-39-4
EPA Ches Code: 022102 |
Hetolachlor
CAS Mo. 51218-45-2
EPA Chen Code: 108801
1.38 E-1
LI var tumors (benign and malignant); CD-I
•Ice (M).
Benign adrenal pheochromocytomas in N I
pituitary adenomas in F; Sprague-Dawl ey
rat«. Alveolar/bronchial adenomas t car-
cinomas; CQ-1 nice (M*F). (All lesions
were within >fstor leal control range).
Increased incidence of skin papillomas in
•ice In ah Initiation-promotion study.
Liver adenomas and contained adenomas/
carcinomas; Charles River CD(SD)BR rats
(F). (Sane liver neoplasia in female rats
was also observed In a separate repeat
study) •
Data not reviewed by OPP.
Assessment based on .the lack of a second car-
et noflenic I ty study in another species.
Assessment based on lack of-daia concerning
carcinogenicity in huaans < inconclusive data
in animals. This assessment is located on
IRIS. OPP has not reviewed this chemical.
Assessment based on lack of data concerning
carcinogenicity in humans t inadequate animal
data. This assessment is located on IRIS.
OPP has not reviewed this chemical.
CSyn. Bromomethane)
Assessment based on lack of data concerning
carcinogenicity in humans or animals.
This assessment is located on IRIS. OPP has
not reviewed this chemical.
RFDC based classification on inadequacy of
the data set and on what was considered to be
a border line significance of the tumors
observed in rats and mice.
This assessment is located on IRIS. OPP has
not reviewed this chemical.
ISyn. metaJCresdll
HCPRC reccmuended that a Margin of Exposure
(HOE) methodology be used for the estimation
of human risk.
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DATE: 05/27/98
OFFICE Of PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 21
CHEMICAL
Metrtbusin
CAS No. 21087-64-9
EPA Che* Code: 101101
CURRENT OPP
1 CLASSIFICATION
D
TUMOR TYPE / SPECIES
Pituitary adenomas; SPF Ulster rats (F)
POTENCT Q*
VALUE
'
SAP
CLASS
CRAVE
CUSS
l>
COMMENTS
Nates: 1993 rat study in Fischer COf(f-JU)/
8R rat* was negative. Chenical structurally
related to Ethiozln, which was associated
it/thyroid cell adenoma I combined adenomas/
carcinomas in Fischer 34* rats
-------
>ATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 22
CHEMICAL
VCURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY 0* I SAP
VALUE I CLASS
CRAVE
CUSS
COMMENTS
torfluraun
CAS Ho. 27314-13-2
EPA Chea Code: 105801
irthopheny(phenol t Ha salt
CAS Ho. 90-43-7
EPA Cheej Code: 064103
iryialtn
CAS No. 19044-88-3
EPA Chen Code: 104201
ixadlazon
CAS No. 19666-30-9
EPA Che» Code: 109001.
taadixyl aclobutrazol
CAS No. 76738-62-0
EPA Che. Code: 125601
•aradlchlorobenzene
CAS No: 106-46-7
EPA Chen Code: 061501
$2
21 (IARC)
C(q)
Cleft
C(q>
Not Likely
C(q)
•2
Liver adenoma ft combined liver adenonae *
carcinows; CD-I ate* (N).
Multiple tueor type* in Multiple studies.
Malignant urinary bladder ft kidney tunor*
(M); Papllloaes of the urinary bladder ft
uterine endoeetrlue (F); F344/DuCrj t F344
rats
Multiple sites (thyroid, nonary); F344
rats (N ft F). -
Hepatocellular adenoma* (by pair-wise
comparison ft with a dose-related trend);
Nan-Mi»tar rats (M ft F).
Liver (adenomas, carcinomas ft combined
adenomas ft/or carcinomas); CD-I mice (N).
Lung tueors; NMRI Wee (M).
Kepatocellular tumors (M ft F) ft rare kid-
ney tuaors ; F344 rats.
Data shotting chesiical has clastogenic
activity provided additional support.
Benign stroul polpys (F); Leydlg cell
tunors (M); Sprague-Dauley Crl:CO(SO)BR •
rats.
Liver (adenomas and carcinomas); B6C3F1
•lce(NftF).
1.3 E-1
liver tuaors (Malignant, combined I 1.4 E-1
malignant t benign); CR CD-I mica
-------
DATE: OS/27/98"
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: Z3
CHEMICAL
.'CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY 0* I SAP I CRAVE
VALUE . CLASS I CLASS
COMMENTS
Parenttrophenol
CAS No. 100-02-7
EPA Choi Code: 056301
Paraquat dfchloride
CAS No. 1910-42-5
EPA Cheai Code: 061601
Parathlon (Ethyl parathlon)
CAS No. 56-38-2
EPA Che* Code: 057501
PendinethalIn
CAS Ho. 40487-42-1
EPA Che* Code: 108501
Pentach t oronlt robeiene
CAS No. 82-68-8
EPA Che* Code: 056502
Pentachlorophenol
CAS No. 87-86-5
EPA Che* Code: 063001
Perec thrln
CAS No. 52645-53-1
EPA Che* Code: 109701
PhenaedfphM (Bet ana I)
CAS No. 11684-63-4
EPA Chen Code: 098701
Phenol
CAS No. 108-95-2
EPA Che* Code: 064001
Phorate (Thimet)
CAS No. 298-02-2
EPA Che* Code: 057201
Phosaet (laidan)
CAS No. 732-11-6
EPA Cheai Code: 059201
C
3 (IARC)
62
3 (IARC)
C(q)
3 (IARC)
Adrenal cortical tuaor* (adenoata* +
carcinomas; Thyroid follicular cell
•denoBB* * pancreatic call carclnoam;
Otborne-Mendel rat (M); Benign pancreatic
tuKtrs; Uistar rat (M)
Thyroid folUeular cell
Oewley rata (Hi F)
adenoMt; Sprague-
Thyroid follicular cell adenoMS (fay both
pair-Miae t trend analyst*) in Mies with
a poaitiva trend In feaales; CO rat*.
Hepatocellular adehoaia* t earcinoMS, adr-
enal awdulla pheochronocytoM* t Malignant
pheoctiroanc'ytomas, */or heaMngiesarcaena t
heaanaloam in one or both aexa of B6C3F1
•ice. • ;
Lung (adenoMS 1 coablned •denomt/carcln-
OM); Liver (adenoM); CO-1 aiice (F).
1.29 E-1
1.84 E-2
B2
0 (CRAVE)
Tentative C
Liver tuaors (adenomas C adenoma* +
carcinomas conb(ned) (M); Trend for liver
liver adenoma t carcinoma (F); 86C3F1 nice
Classification based on Inadequacy of the
data base, i.e. lack of carcinogeniclty data
In a second eni*al species.
OPP t6 reevaluate uhen new data on powdered
diet are aubaritted. SAP concerned with nasal
iquaiaom cell carcinoaa seen in Fischer 344
rata (M). l
Mouse carcinogenicity study should be
repeated but not using B6C3F1'strain of nice.
B2
Pend.
CRAVE Q* ».1.2 E-1 (O).
I RfOC considered the dose levels in both
I carcinogenicity studies (rat t aUae) to be
I Inadequate.
.Assessment based on lack of data concerning
carcfnogenicity in huwns i inadequate animal
data. This assessment ia located on IRIS.
OPP has not reviewed this cheerfcal.
OPP requests a 90-day study in mice to deter-
mine whether the doses in the mouse carcfnog-
enicity study would inhibit ChE in plasma.
RBC or brain or cause other toxic effects.
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DATE: 05/27/98
OFFICE Of PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PACE: 24
CHEMICAL
CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY Q*
VALUE
SAP
CLASS
CRAVE
CLASS
COHKENTS
Phosphamidon
CAS No. 13171-21-6
EPA Che* Code: 015201
ftiosphfne
CAS Ho. 7803-51-2
EPA diem Codt: 066SOO
Phostebupfrim (Bay mat 7484)
CAS No. 96182-55-5
EPA Chem Code: 129606
Picloram (* sall«)
CAS No. 1918-02-1
EPA Chem Code: 005101
Piperonyl butoxide
CAS No. 51-03-6
EPA Chem Coda: 067501
Polychlorineted biphenyls
CAS No. 1336-36-3
EPA Chem Codt: 017801
Prallethrln (ETOC)
CAS No. 23031-36-91
EPA Chem Code: 128772
Prtmisulfuron-mtthyl
CAS No. 86209-51-0
EPA Chem Code: 128973
Prochloraz
CAS No. 67747-09-5
EPA Chen Code: 128851
Procynidone (Sunileit)
CAS NO. 32809-16-8
EPA Chen Code: 129044
rodiamfoe (Rydex)
CAS No. 29091-21-2
EPA Chew Code: 110201
D (CRAVE)
B2 (CRAVE)
C(q>
B2
Bladder transitional cell earefr
Hepatocellular carcinoma; Sprague-Dattley
rats (M>
Assessment based on lack'of data concerning
carcinogen!city in hunans f inadequate data
In animals. This assessment is located on
IRIS. OPP has not reviewed this chemical.
Increased incidence of hepatocellular
tuaors (N « F) (adenomas, carcinomas
combined edenomaa/carcincmas In mala* ft
adenoma* In females); CD-I mice
*
Hepatocellular carcinoma*; Fischer 344.
Sprague-Oeuley t WUtar rate; dd I BALB/cJ
mica. Inadequate yet suggestive evidence
of excess risk of liver cancer in huaans
by ingest ion, inhalation or dermal contact
Mepatocelluiar adenomas t carcinomas; CO-1
mice (M t F) IThe 2 dose levels Here these
tuaors occurred were excessively toxicl.
Hepatocellular adenoma t carcinoma.
combined adenoma/carcinoma; CD-I mice (M *
Ineratitial cell adenoma (H); Pituitary
adenoma (f); Osborne-Mendel rail. Liver
adenomas t combined adenomas/carcinomas;
B6C3F1 Mice (F>
Thyroid foilIcolar cell neoplasia;
Pancreatic adenomas; Sprague-Dauley rats
(N t F). Flbroearconat; CO-1 mice (M)
7.7 E«0
B2
This assessment is located on IRIS.
not reviewed by OPP.
OPP has
Syn, Beacon. NCPRC did not recomaend to re-
peat the mouse study.
1.5 E-1
2.35 E-2
1.92 E-2
0* Potency
rate rats.
2.35 E-2 female mice; 1.92 E-2
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DATE: 05/27/98
CHEMICAL
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 25
| CURRENT. OPP
CLASSIFICATION
TUMOR TVPE / SPECIES
POTENCY Q* I SAP 1 CRAVE
VALUE I CLASS
COMMENTS
Profenofos (Curacron)
CAS Ho. 41198-08-7
EPA Che* Code: 11 HOI
Promton
CAS No. 1610-18-0
EPA Chcm Code: 080604
.Prone tryn
CAS No. 7287-19-6
EPA Che* Code: 080805
PronsMide (Kerb)
CAS Mo. 23950-58-5
EPA Che* Code: 101701
Propachlor
CAS No. 1918-16-7
EPA Che* Code: 019101
Propanocarb hydrochtorlde
CAS No. 25606-41-1
EPA Che* Coda: 119302
Propargite (Onlte)
CAS No. 2312-35-8
EPA Che* Code: 097601
Prop*tine
CAS No. 139-40-2
EPA Che» Code: 080808
Propiconatole (Bsmer/TUt)
CAS Ho. 60207-90-1
EPA Che* Code: 122101
Propylene oxide
CAS Ho. 75-56-9
EPA Chew Code: 042501
Prosulfuron (CGA-152005)
CAS No. 94125-34-5
EPA Chem Code: 129031
likely
C(q)
82 (CRAVE)
Masaury tutor; Sprague-Dauley rat* (F)
Hepatocelluler adenomas/careinosas; B6C3F1
ft C57ll6xC3h/Anf Mice (M)
Multiple tuBors/sultiple sites; Rare stom-
ach tueor; Fischer 344 rat (M); Thyroid
tutors ft grenulosa/theea celt tuMrc;
Spraffue-Dauley rate (N ft F).
Hepatocellular tuaors; CO-1 Mice (M)
Statlaticatly significant increase* in
undlfferentiated aarcaaus in the jejunui;
CrUCOBR rat (M ft F).
StatUtically •ionificant Increase* in
•Maary 9| and adenonat. carclnoM* and
caabined adehoMt/carcinoM*; Sprague-
Dauley rat (F)
Hepatoceltuar •denomas, carcihows. ft
adenoaMS/carclnojMS coMbined; CD-I Mice
00
Benisn ft •allgnant tuwre at the aite of
exposure O»en exposed by sUxrutaneous in-
jections (NMRI mice), by Inhalation
(F344/H, CpBrUU Uistar rata ft B6C3F1 mice)
ft by gavage (Sprague-Oauley rats).
Nanawry gland adenomas ft adenocarcinomas
(F); Interstitial cell tutors (M);
Crl:CO(SO)Blt rats
1.54 E-2
1.71 E-2
4.45 E-2
2.4 E-1 (0)
3.7 E-6 (I)
Pend.
82
A linear low-dose approach'for htnen risk
characterisation C extrapolation of risk
should be based on both neoplastic (ovarian
tutor* (rats) ft liver tunors (M nice)} t non-
neoplestlc (liver hypertrophy (Mice) lesions.
RFDC considered the carcinogenic!ty phase of
the rat atudy to be unacceptable. The mouse
carcinogenicity atudy Has also considered
unacceptable.
HCPKC deternined the mouse carcinogenicity
atudy to be inadequate. However a new study
is not required.
HCPRC recosswnded that for the purpose of
risk eharacteriiation a ton-dose extrapolat-
ion swthodolgy (0.1*) be applied to the animal
data.
This assessment is located on IRIS. WP has
not reviewed this Chemical.
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JE: 05/27/98
CHEMICAL
Tethrlnt
CAS No. 121-21-1.
EPA Chew Cod*: 069001
Ttdaben
CAS No. 96489-71-3
EPA dim Code: 129105
TlMthanil •
CAS No. 55112-28-0
EPA Chen Code: 288201
M-ithlobBC-sodiuB)
CAS NO. 1233*3-16-8
EPA Chest Code: 078905
i indorse (Facet)
CAS No. 84087-01-4
EPA Che* Code: 128974
litelofop ethyl (Assure)
CAS No. 76578-H-8
EPA Chen Code: 128201
:ss*thrin
CAS No. 10453-86-8
EPA Che* Code: 097801
iMulfuron (OPX-E9636)
CAS No. 122W»-*f-0
EPA CheevCode: 129009
itenone
CAS No. 83-79-4
EPA Oie» Code: 071003
•lenitn end compound*
CAS No. 7782-49-2
EPA Chea Code: 072001
Iver
CAS NO. »**•»:*
EPA Chen Code: 072501
CURRENT OPP
CLASSIFICATION
OFFICE OF PESTICIDE PROGRAMS LIST Of CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
TUMOR TYPE / SPECIES
PAGE: 2ft
POTENCY fl* I SAP CRAVE
VALUE I CLASS | CLASS
COMMENTS
Deferred
liver adenomas, carcinomas * combined
adenoma/carcinoma; CD-1 Mice (M).
Rare kidney tubular adenomas, eerclnoe«« ft
cort>imd •denow/eerclnoM; Crl.-CDBR rats
'<">• ..'-.' ' ••.
Equivocal Increase Iri pencreatlc aclnar
cell adenoMt;.Ulster rets (N).
combined);
1.05 E-3
1.25 E-2
liver (adenomas C caret
CD-I mica (M).
Def.
D (CRAVE)
D (CRAVE)
»arcoma» have been Ind-
eater^tation of foil. I d sc.
of silver. Interpretation of these find-
ings has been questioned due to the phen-
oMnen of solid-state ctrelnogenesls.
| Classification uiil be reconsidered pending
I HCPRC review of the laboratory pathology peer
I review.
Referred to HCPRC by RFDC.
1st Potency Q* value, is based upon male rat
kidney tufcuIar (adenomas and/or adenocarcin-
MS) tuaors. 2nd value based on nale souse
liver (adenomas and/or carciiwaus) tuners.
HCPRC concluded that limitations in the data
fro* the anuse study precluded an accurate
Interpretation of carcinogenic risk. No ne«
anlMle studies are required.
Referred to HCPRC by RFDC.
Assessment based on inadequate huwn data •
inadequate evidence of carcinogenicity in
anisMlf. This assessment is located^! IRIS.
OPP has not reviewed this chemical. '
This assessment is located on IRIS.
not reviewed this chemical.
OPP has
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DATE: 05/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEHICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 27
CHEMICAL
t\CURRENT OPP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY 0*
VALUE
SAP
CLASS
CRAVE
CLASS
COMMENTS
SUvex <2,4,5-TP>-
CAS No. 95-72-1
EPA Che* Code: 082501
SiMttne
CAS No. 122-34-9
EPA Chew Code: 080807
Sodiun onadine
CAS No. 15922-78-8
EPA Chen Code: 088004
Sulfellate
CAS Mo. 95-06-7
EPA Che* Code: 039001
Sulfentrazone
CAS Ho. 122836-35-5
EPA Chea Code: 129081
Sulprofoe (Herafos/Bolatar)
CAS Ho. 35400-43-2
EPA Chen Code: 111501
Sumilarv (Pyriproxyfen)
CAS No. 95737-68-1
EPA Chen Code: 129032
TCHTB (Busan 72)
CAS No. 21564-17-0
EPA Chen Code: 035603
Tebuconazole (Folicur) -
CAS No. 107534-96-3
EPA Chen Code: 128997
Tebufenoxide
CAS No. 5902-51-2
EPA Chen Code: 129026
Tebuthiuron
CAS No. 34014-18-1
EPA Chen Code: 105501
0 (CRAVE)
C(q)
3 (IARC)
28 OARC)
Pituitary gland carcinomas; MaaBary gland
carctnoMi; Sprague-Dawley rats (F)
1.2 E-1
Maiawy gland tuaors (F). lung tutors
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ITE: 05/27/98
CHEMICAL
CURRENT Off
CLASSIFICATION
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
TUMOR TYPE / SPECIES
PAGE: 28
POTENCY 0* I SAP I CRAVE
VALUE I CLASS I CUSS
COMMENTS
eflubehzuron
CAS No. 83121-18-0
EPA Q»m Code: 129048
srbectl
CAS No. 5902-51-2
EPA Chem Code: 012701
trbufos
CAS No. 13071-79-9
EPA Chen Code: 105001
erbuthylazine
CAS No. 5915-41-3
EPA them Code: 080814
erfautryn
CAS NO. 886-50-0
EPA Che* Code: 080813
errazole
CAS NO. 2593-15-9
EPA Chen Code: 084701
etrachloroethane, 1,1,2,2-
CAS Ho. 79-34-5
EPA Chen Code: 078601
etrachlorvtnphos (Garden*)
CAS No. 961-11-S
EPA Chen Code: 083701
etrenethrin
CAS NO. 7696-12-0
EPA Che* Code: 069003
hslUun(l) sulfate
CAS No. 7446-18-6
EPA Chen Code: 080001
rhiafluamide (FOE 5043)
CAS No. 142459-68-3
EPA Chen Code: 121903
Pending
82
C (CRAVE)
CCq)
•eferrad to HCPRC by RFDC.
Benign interstitial cell tuaors of the
testes (M), mamaary gland carcinomas (F>;
Tif:RAIf rat*
Mamary (adenomas/adenocarcinomas); Liver
(adenomas/carcinomas) (F)j Thyroid follie-
ular (adenomas/carcinomas); Testicular
Interstitial celt adenoM (N); CR CO-1
•ice.
Multiple tuajora (liver, bile duct, mammary
gland, thyroid, I tastes) i cholanglocar-
cinema
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DATE: OS/27/98
OFFICE OF PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 29
CHEMICAL
I S°
I CIA!
CURRENT OPP
iSSIFICATION
TUMOR TYPE / SPECIES
POTENCY 0*
VALUE .
SAP
CUSS
CRAVE
CLASS
COMMENTS
Thiaiopyr ice
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DATE: 05/27/98
OFF ICE,Of PESTICIDE PROGRAMS LIST Of CHEMICALS EVALUATED FOR CARCINOGENIC POTENTIAL
PAGE: 30
CHEMICAL
Tribufos (TrtbuplKW/OEF)
CAS No. 78-48-8
EPA Cheat Code: 074801
CURRENT OPP
CUSSIFICATION
likely (high
dMM>
Unlikely
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Off ICE Of PESTICIDE PROGRAMS LIST OF CHEMICALS EVALUATED FOR CARCINOGEHIC POTENTIAL
PAGE: 31
CHEMICAL
CURRENT OCP
CLASSIFICATION
TUMOR TYPE / SPECIES
POTENCY 8*
VALUE
SAP
CLASS
CRAVE
CLASS
COMMENTS
Hphenyltin hydroxide
CAS Ho. 76-87-9
EPA ChM Code: 083601
roysani polyphase (IPBC)
CAS No. 55406-53-6
EPA Chea Code: 107801
OMM
CAS No. 57-14-7
EPA Chea Code: 600018
MP-488 (PAL 6000)
CAS No. 111578-32-6
EPA Che* Code: 129025
niconazole (Prunit)
CAS Mo. 83657-22-1
EPA Chen Code: 128976
inclozolin (Ronilan)
CAS No. 50471-44-8
EPA Che* Code: 113201
Hilt* phosphorus
CAS No. 7723-14-0
EPA Chea Code: 066502
lyU
CAS No. 1530-20-7
EPA Che« Code: 086802
!inc and compounds
CAS No. 7440-66-6
EPA Chea Code: 129015
Mneb
CAS No. 12122-67-7
EPA Chen Code: 014506
Not Likely
•2
Pituitary gland adenoaa (F); Leydlg cell 2.8 E-0 • 02
tutors (M); tlistar rat. Hcpatocettular .
edenoaas (N i F); coafcined hepatocetlular
(adenoM i/or earelnoaa) (F); NMRI •ice.
Multiple sites (eg. lungs, vessels. liver- I 4.6 E-1 (N) I Defer.
i kidney); Multiple species, strains 1 I 3.1 E-1 (F)
studies.
Hepatocelluter adenoaa*, carctnonas t -
S/carclnoaas cosfctned; CO-1 aice
92
0 (CRAVE)
D (CRAVE)
D (CRAVE)
3 (IARC)
Statistically significant increases in
Multiple tuaor -types (testiculer Leydig
cell & prostate adenoaas) and ovarian
adenoass in feaales; Ulster rats
UDMM is the aetabolIte/breakdoun product of
Daainoxide (Alar).
(Syn. unsyaaetrical 1,1-dinethylhvdraxine)
NCPRC concluded that for the purpose of risk
characterization, a non-linear approach -
Margin of Exposure (NOE) should be wed for
quantisation of huasn risk.
Assessaent based on lack of data concerning
earcinogenlclty in huaans or animts.
This assessaent is located on IRIS. OPP has
not reviewed this cheaical.
Assessaent based on lack of data concerning
carcinogeniclty tn huaans I inadequate anfaal
data. This assessaent is located on IRIS.
OPP has not reviewed this cheaical,
Assessaent based on inadequate evidence in
tiuaans t aniaals. This assessment is located
on IRIS. OPP has not reviewed this cheaical.
-------
EPA WEIGHT-OF-THE KVTnENCE CATEGORIES
Group A - Human carcinogen
Group. B - Probable human carcinogen
Bl - Indicates limited ..human evidence
B2 - Indicates sufficient evidence in animals and inadequate or
no evidence in humans
Group C - Possible human carcinogen
Group D - Not classifiable as to human carcinogenicity
Group E - Evidence of noncarcinogenicity for humans
PROPOSED EPA WEIGHT-QF-THE EVIDENCE CATEGORIES
Known/Likely - This category of descriptors is appropriate when the
available tumor effects and other key data are adequate to
convincingly demonstrate carcinogenic potential for humans.
Cannot Be Determined -This category of descriptors is appropriate when
available tumor effects or other key data are
suggestive or conflicting or limited in quantity and,
thus, are not adequate to convincingly demonstrate
carcinogenic potential for humans.
Not Likely - This is the appropriate descriptor when experimental evidence
is satisfactory for deciding that there is no basis for human
hazard concern.
IARC
Group 1 - The agent (mixture) is carcinogenic to humans
Group 2A - The agent (mixture) is probably carcinogenic to humans
Group 2B - The agent (mixture) is possibly carcinogenic to humans
Group 3 - The agent (mixture, exposure circumstance) is not classifiable
as to its carcinogenicity
Group 4 - The agent (mixture, exposure circumstance) is probably not
carcinogenic to humans •
CAG
CRAVE
Def.
Defer.
F
HCPRC
HAZID
(I)
IARC
Int.
IRIS
M
(O)
OPP
ORD
Pend.
Q*
ACRONYMS
Cancer Assessment Group
Carcinogen Risk Assessment Verification Endeavor
Deferred
Deferred
Female
Health Effects Division Carcinogenicity Peer Review Committee
Hazard Identification Assessment Review Committee
Health Effects Division
Inhalation (ug/cu.m)"1
International Agency for Research on Cancer, World Health
Organization
Interim
Integrated Risk Information System
Male
Oral (mg/kg/day)"1
Office of Pesticide Programs
Office of Research and Development
Pending
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SAP . - FIFRA Scientific Advisory Panel
SAB - Scientific Advisory Board
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US EPA Pesticidal Chemicals Classi...able or Possible Human Carcinogens
http://www.epa.gov/pesticides/carlist/table.htm
SEPA
vx
Office of Pesticide Programs
Pesticidal Chemicals Classified as Known, Probable or Possible
Human Carcinogens
Group A Pesticides: Human Carcinogens; Not Classified by OPP
Group Bl Pesticides: Probable Human Carcinogens with Limited Human Evidence- Not
Classified by OPP
Group B2 Pesticides: Probable Human Carcinogens with Sufficient Evidence in Animals and
Inadequate or No Evidence in Humans; Classified by OPP ,
Group B2 Pesticides: Not Classified bv QPP • .
Group C Pesticides: Possible Human Carcinogens; Classified by OPP
Group C Pesticides: Not Classified by OPP
Other Pesticides: Not Applicable under Current Classification; Classified by OPP
Other Pesticides: Not Classified by OPP
Classifications under Proposed Revised Guidelines: Classified by OPP
Definitions
Group A Pesticides
Human Carcinogens
Not Classified by OPP
Note: Sine? the evaluation of many of these chemicals is an ongoing process, the information on this iist may change,
i.e., a classification may change. '
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Active Ingredients
(Arsenic, inorganic
Benzene
jChromium VI
Coal Tar (Coke Oven
Emissions)
Ethylene Oxide Group
(IARC, 1994) -see
also under Group Bl
Registration Date ] Use Pattern
1972
1948
'
- 194$
1957
indoor/outdoor;
wood preservatives;
food use
food use;
animal use
Regulatory Status
Food uses voluntarily
cancelled 1993
remaining uses are ant
baits (in crp) and wood
preservatives
Voluntary cancellation
7/31/85
wood preservative |(see Arsenic, inorganic)
indoor/outdoor use;
wood/non-wood use
food use;
non-food use;
fumigant
All uses canceled
5/15/86 except wood
use (label restrictions) ]
Tolerances reassessed
by 8/99
Group Bl Pesticides
Probable Human Carcinogens with Limited Human Evidence
Not Classified by OPP
Note: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change,
i. e., a classification may change.
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Active Ingredients
Acrylonifrile
UaHmiurn
i
VTCUMJIC =
- ' \
• • \
lEthylene Oxide !
i(OHEA, 1985) -see |
also under Group A !
Formaldehyde |
Registration Date
1/1776
1959
1948
1957
i
1948
I Use Pattern
'stored tobacco;
(food processing areas; .
iterrniticide
|lawn/turf
i
i
iwood preservative
1 • •
[food use;
Inon-food use
jfooduse
l • . • -.: :
Regulatory Status
Canceled 10/28/80 j
t -j- r .J
Last product canceled I
12/29/86
Classined.as restricted
use in 198 5
Tolerances reassessed
by 8/99
olerances reassessed
by 8/99
Group B2 Pesticides .
Probable Human Carcinogens with Sufficient Evidence in Animals and Inadequate or No
Evidence in Humans
Classified by OPP
Note: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change,
i.e., a classification may change.
Go to TOD of Page
Active Ingredients
Acetochlor
Aciflurofen, sodium salt
Registration Date
3/11/94
-
,9/20/M -
Amitrole I960
i . ' '
Cacodylic Acid
(Captafol
Captan
Chlordimeiorm
i
Chloroaniline
1954
1962
1949 .
1970
1967
Cyproconazole j 12/22W
•i . • " | ' '
jDaminozide (Alar)
r,2-Dichloropropene
(Telone)
i
"1963
i
- — ~ 1960
Use Pattern
Food use (com and .
soybeans)
food use
outdoor use (right of
ways)
food use
food use
food use
food use (cotton only)
seed treatment;
foliar treatment
food use
food uses;
non-food uses
food uses
Regulatory Status
^ . — -i —
tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
?LED issued 11/22/96
n> — I ~3 —
Tolerances reassessed
by 8/99
(All products
voluntarily cancelled
5/15/87
Tolerances revocation
by 8/99
imf. 1 T
Tolerances reassessed
by 8/99'
(yy-u'— .... . ••• •
Voluntary cancellation
9/19/88
uses canceled
FR 3702 1977
(w — I i ~ — 3 —
Tolerances reassessed
by 8/99
Tolerances revocation
3/19/90
nrr — r — I " — '
No tolerances
established at the time
of registration under
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\\JSDA
iCurrently in Special
IReviewfor
jgroundwater issues
1,1-Dimethylhydrazine i 1960 . food uses; Tolerances revocation
(UDMH) non-food uses by 3/1 9/90
Dipropyl ; . 1958 - , |
isocinchomeronate !
(MGK 326) . | . -
Fenoxycarb
I
':
Folpet :
V
Furrnecyclox
Haloxyfop-methyl
Lactofen
Mancozeb
.
Maneb '
i
Metam Sodium
Orthophenylphenol .
Oxythioquinox
Procymidone
Pronamide • J
. •
Propargite
i "
Propoxur (Baygon)
1985
1948
pending registration
non-food use (topical (Routine registration
animal use) {activities;
no pending use
food uses;
non-food use
(non-bearing fruit
trees);
indoor/outdoor;
domestic animal
food use
wood preservative
pending registration jno food uses
3/18/87
1962 ..:
1954
i 1955
1948
1963
import use only
10/11/72
1976
1976
IPropylene Oxide j 1971
Terrazole
Thiodicarb
jTriphenyltin hydroxide
1966
•
2/10/84
2/26/85
food use •
food use ,
v
food use
food use
food use
food use
EUP on pears expired
8/97;
new uses (pome fruit,
citrus, tree nuts,
pasture grasses and
cucurbits established)
Tolerances reassessed
by 8/99
No action from.
company since 1987
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/02
Tolerances reassessed
by 8/99
Tolerances reassessed
by8/99
food use (wine grapes) (Tolerances reassessed
jby 8/99
food use
food use
no food uses;
greenhouse;
indoor/outdoor uses
fbocTuse
food use
food use
food use
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99.
RED to be issued in
early 1998 .
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
|by8/99
Group B2 Pesticides
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Probable Human Carcinogens with Sufficient Evidence in Animals and Inadequate or No
Evidence in Humans
Not Classified by OPP
Note: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change,
i.e., a classification may change.
Go 10 Top of Page
Active Ingredients Registration Date
Use Pattern Regulatory Status
Acetaldehyde - This pesticide no longer has registered food uses and UPF is m the process oi
revoking Tolerances associated with this chemical.
Aldrin
1
1949
'
fooduse; i
aon-fooduse; 1
termiticide <
\11 uses including
ermiticide uses
:anceled 1989
j Aniline - not registered as active ingredient but as an analog
Aramite
1 • ' •
1951
use on roses
. ... 1
All products canceled
by 1984
jAzobenzene - There are no records indicating registered or pending pesticide products.
IBis(chloroethyl) ether - There are no records indicating registered or pending pesticide products.
jCarbon Tetrachloride
i
Chlordane
I ,
(Chloroform
1,2-Dibromo-
3-chloropropane
(DBCP)
iDibromoethane, 1,2
j(EDB)
j[=Ethylene dibromide]
|
i
1950
5/18/78
fooduse;
fumigant
fooduse;
termiticide
Some uses voluntarily
canceled 1985;
remaining uses canceled
1988
All uses canceled by .
1988
4/23/5
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US EPA Pesticidal Chemicals ClassL.able or Possible Human Carcinogens
http://www.epa.gov/pesticides/carlist/table.htm
[Epichlorohydrin - There are no records indicating registered or pending pesticide products.
jtmyiene tmourea j inert ingredient only
i
i - i
TJT — i — in ' —
Heptachlor
'o«— .* in • j
Heptachlor epoxide
i
i
Hexachloroberizene
m in —
Hexachloro '
cyclohexane, tech.
Lmdane
I 1952
j
1952
9/28/71
i960
9/2/52
in various chemical i 1 his inert no longer in
formulations Ipesticide products by
11987
food use;
non-food use;
termiticide
food use;
non-food use;
termiticide
seed treatment
tooa use
food use;
non-food use;
indoor/outdoor use
All uses canceled 1988
except fire ant use;
RED issued in 1992 for
fire ant use
All uses canceled 1988
except fire ant use;
RED issued in 1992 for
fire, ant use
voluntarily canceled
7/6/84
Some products canceled
7/21/78;
others reformulated to
lindane .
Tolerances reassessed
by 8/99
, etliylene Chlonde (see Uichloromethane) ~
Mirex
Pentachlorophehol
fn n n — i
Perchlorethylene
i
7/30/75
1948
1959
technical formulation
only
no food uses;
wood preservative
non-food use;
indoor/outdoor
Canceled 7/1/87 .
Wood uses canceled in
1986;
ion wood use restricted
labeling and currently
in Reregistration
Process
Canceled in 1992 for
ion support through
Rereaistration
poiycftionnated biphenyls - Considered contaminants. Elimination of all active and inert uses "
jlx/V ., ..
p-Propiolactone - There are no records indicating registered or pending pesticide products.
Toxaphene
19/4 food use . (Canceled 1982
inchlorethylene | 1949 (indoor/outdoor [Products canceled 19S5
inchlorphenol 2,4,6 |. i960 (disinfectant -. ~'(
Canceled 1987
Group C Pesticides
Possible Human Carcinogens
Classified by OPP
Note: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change
i.e.,-a classification may change. '
Go to Top of Page
j Active Ingredients | Registration Date | Use Pattern
iAmitraz - | 3/31/75 [food use
Regulatory Status
Tolerances reassessed
by 8/99
7/16/983:29PM
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Asulam ' 10/24/75 Tooduse 1 1 olerances reassessed
jby8/99
Atrazine 1959 tooduse;
non-food use 1
Benomyl 1969 looduse;
lindoor/outdoor use
i • i
Bifenthrin
Bromacil
•
Bromoxynil
Calcium Cyanamide
Carbaryl
Clofentezine
jCyanazine
Cypermethnn
Dacthal •
Dichlobenil
Dichlorvos (DDVP) .
Diclofop-methyl
Dicofol
Difenoconazole
Dimethenamid (SAN 682H)
Dimethipin (Harvade)
Dimethoate
Dinoseb
Ethalfluralin
i ,
[Ethofenprox
Fenbuconazole
10/2/85 1
1963 11
i
4/25/88 -
2/25/72 |
• -
1963
• j/tO/89
12/6/71 .
6/12/84
1958
1982
1948
3/31/80-
1957
8/4/94
.- ,. ':3/5/98. .
• 8/13/82
tooduse
food use;
non-food use;
indoor/outdoor use
food use
.
food use;
non-food use
food use;
non-food use
food use;
non-food use
food use
food use
food use;
non-food use
food use;
outdoor use
food use;
non-food use
food .use
food use;
outdoor use
food use (wheat use
only)
food use
plant growth regulator
1962 tooduse;
non-food use
1976
12/5/83-
food use; •
non-food use;
indoor/outdoor use
food use;
non-food use;
indoor/outdoor use
pending registration non-rood use
2/5/92
ifood use
L olerances reassessed
?y 8/99
Folerances reassessed
?y 8/99
tolerances reassessed
?y8/02
Folerances reassessed
by 8/9?
Folerances reassessed
by 8/99
Canceled 1984
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/02
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/06
Tolerances reassessed
by 8/02
Tolerances reassessed
by 8/99
Ail uses canceled
6/9/89
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
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Fipronil 1 5/1/96 food uses (corn only); Corn use registered
i (domestic animals; 1 1/14/97;
indoor bait stations jother uses pending
Fluometuron \ 8/7/73 ifood use (grapes and iTolerances reassessed
- cottononly) by 8/02
Fomesafen 1- 4/10/87 food use (soybeans [Tolerances reassessed
1 (only) (by 8/99
Hexaconazole j 9/26/96 (import use food use (import use [Tolerances reassessed
only) Jon bananas) jby 8/99
Hexythiazox (Savey) . -4/13/89
; ,
Hydramethylnon (Amdro) 8/20/80
.•••••''
food use;
non-food use
food use; •:
non-food use
Hydrogen cyanamide 11/29/93 plant growth regulator
'.-'•: (grapes and kiwi)
Imazalil
Isoxaben
Linuron
2-Mercapto benzothiazole
..
Methidathion
[Methyl 2-benzimidazole
carbamate (MBC)
Metolachlor
1 . '
Molinate
[Nitrbfen
Norflurazon
N-Ocryl bicycloheptene
dicarboximide (MGK-264)
Oryzalin
Oxadiazon
Oxadixyl
Oxyfluorfen
7/18/83
6/16/89
1/2/67
1956
2/12/76
5/3/90
. 4/1/77
1965,
12/7/66
.1/21/74 •
.3/15/50
3/15/74
. 5/24/77^
2/27/92
5/17/75
food use
food use
food use;
outdoor use
aquatic indoor
food use
no food uses;
sanitizer,
algicide
food use
food use (rice only)
food use
food use
food use;
non-food use;
indoor/outdoor use
food use
{food use
i
food use
food use
lolerances.reassessed
t>y8/99
Folerances reassessed
t>y 8/02 '
New uses under
consideration
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/06
Tolerances reassessed
by 8/02
Products canceled
due to maintenance
fees and DCI.
Tolerances
revocation by 8/02
Tolerances reassessed
by 8/99
RED scheduled after
2002 -
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Voluntary
cancellation 9/15/83
Tolerances reassessed
by 8/02
Tolerances reassessed
by 8/02
Tolerances reassessed
by 8/99
Tolerances reassessed
by8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
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(Paradichlorobenzene
[Parathibii
Ifendimethalin
1949 jnon-food use; 'Regular registration
_____ imdoor/outdoor use jactivities
1948~
7/29/75'
, (food use
I
jtbod use
(Pentacliforonitrobenzene
Hermethrin
'hosmet
4/11/79
1966
FHospEarmdoir
7/26/60
[food use;
(non-food use;
greenhouse (indoor)
ifood use;
non-food use
food use; ~
non-food use
food use
11 olerances reassessed
jby 8/99
11 olerances reassessed
|by8/99 .
I olerances reassessed
by 8/99
Fiperonyl butoxide
Prochloraz
8/29/57
Prodiamine
Fropazine~~
An experimental use
permit only issued
11/10/88
2/7/92
tooduse;
non-food use;
greenhouse (indoor)
Tolerances reassessed
by 8/99
1 olerances reassessed
by 8/99-
Tolerances
revocation by 8/99;
products canceled
6/15/84. -
Tolerances reassessed
by 8/02
food use
Fropiconazole
j4-Pyridazine carboxylic acid,
2-(4-chlorophenyl)-3-ethyl-
2,5-dihydro-5-oxo-,potassium
salt (MON 21200)
-post FOPA
jPyrithiobac-sodium
1961
8/14/81
2/26/97
food use
1 emporary tolerances
expired 11/21/89
tooduse;
outdoor use
food use
jbimazine
|Iebuconazole
9/29/95
1959
(Terbutryn
7/15/74
7/29/74
food use (wheat only)
[olerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Regular registration
activities;
no new pending uses
tooduse;
non-food use
tood use (peanut)
jnon-tood use
j2-(Thiocyanomethylthio)
jbenzothiazole (TCMB)
jTriadimefon
Triadimenol
Trial late
4/28/89
2/15/62
tood use (cotton only) [Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
'i'olerances reassessed
by 8/99
Tolerances
revocation by 8/99
(canceled 1/22/91)
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
[Tolerances reassessed
12/11/69 ~|tooduse;
(wood preservative
8/27/79 ifood use :
food use
tood use
7/16/983:29PM
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jTribenuron methyl i 6/30/89
i i
jlndiphane j 2/10/86 .
j 1 rifluraiin 1/15/73
i i . '
! . ' •!
, nrlusulturon-methyl 2/4/92
jUniconazole 7/3/91
1 -•• • ' :'
jvmclozolin 2/11/81
1 ' ' • - '
|food use
itbod use
itbod use
tood use (sugar beets)
plant growth
regulator;
no food uses
food use
by 8/99
lolerances reassessed
by 8/02 ,
lolerances reassessed
by 8/02
lolerances reassessed
by 8/99
1 olerances reassessed
by 8/02
Normal registration
activity
i olerances reassessed
by 8/99
Group C Pesticides
Possible Human' Carcinogens
Not Classified by OPP
Note: Since the evaluation of many of these chemicals is an ongoing process, 'the information on this list may change
i.e., a classification may change. s.
Go to TOD of Page
Active Ingredients
Acrolein
ltJfoVdr>tll/T.rjT.ii(li fC
Registration Date .
11/26/75
Use Fattern
aquatic food crops
(agricultural irrigation
waters)
Regulatory Status
Restricted use chemical;
regular registration
activities
ucxacmuiounaiie - llieie aie no records indicating registered or pending pesticide products
ilsophorone
I
i '
jMetnylphenol, 3-
j(m-Cresol)
•I etrachloroethane,
IM2-, • - , '
i ricriioroethane, 1 , 1 ,2-
inert ingredient
•
tood use
J/ 10/80 food use; ~ '
(wood preservative
9/15/78
non-food uses
12/28/49 jnon-fooduse "~
Company has submitted
for review information
rebutting carcinogen
classification
Currently in
Reregistration process
Canceled 7/«7
Canceled 1992 '
Other Pesticides
Not Applicable under Current Classification
Classified by OPP
,Npte: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change •
~i.e.',-a classijication may change. -
Go to TOD of Page
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US EPA Pesticidal Chemicals ClassL.able or Possible Human Carcinogens
http://www.epa.gov/pesticides/carlist/table.htr
I Active Ingredients
lAliette
[Melamine
i
Registration Date
1988
3/88
Use Pattern
food uses
disinfectant;
sanitizers
Regulatory Status !
RED issued 1990;
all products reregistered i
1992 !
KtL> scheduled for j
2002 }
Other Pesticides
Not Applicable under Current Classification
Not Classified by OPP
Note: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change,
i.e., a classification may change.
Go to Top of Page
Active Ingredients
Rhodamine 3
THPS
(tetrakis(hydroxymethyl)
phosphonium sulphate
(no classification, but
accepted NTP negative
studies)
Registration Date
inert ingredient; ,
date unknown due to
change in data systems
10/12/95 ,
Use Pattern
seed treatment -
formulations only
indoor commercial use
(antimicrobial uses)
Regulatory Status
Currently reviewing
residue data to
ascertain dietary
exposure;
tolerances
reassessment by 8/99
Normal registration
activities
Classifications under Proposed Revised Guidelines
Classified by OPP
Note: Since the evaluation of many of these chemicals is an ongoing process, the information on this list may change.
i.e.. a classification may change.
Likely
Go >o Top of Page
Active Ingredients
Chlorothalonil
•
Ethoprop -
Ipcodione
Isoxaflutole
Propachlor
Registration Date
1966
4/88
1980 .
pending registration
9/3/82
Use Pattern
food use;
wood preservative
food uses
.
food use
food use (corn)
food uses
Regulatory Status
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Tolerances reassessed
by 8/99
-
Tolerances reassessed
by 8/99
Known/Likely
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Go lo Top of Page
[ Active Ingredients j Registration Date
Dluron I 57Z8771
U^TFarteTH
~ltbod use
Likely: High Doses/Not Likely: Low Doses
Go to TOD of Pase
1 olerances reassessed
by 8/02 j
Active Ingredients
jAiactiior
1
l.ribuphos (JJtit)
Kegistration Date
4/75
6/29/61
Use Pattern
food use :
food use (cotton)
Regulatory Status
1 olerances reassessed
by 8/99
Tolerances reassessed
by 8/99
Cannot Be Determined, But Suggestive
Go to TOD of Page
Active Ingredients
Benoxacor
Kegistration Date
inert (safener)
Use Pattern
food use
Regulatory Status
lime-limited tolerances
expires 2/98
Definitions
Analog Back to fable
- a f?™!*!™*1 ^ w similar in structure to another compound.
(Experimental Use Permit) Backjojabje
A permit authorized under FIFRA section 5 that is granted by the Agency to allow
producer to conduct testing of a new pesticide, i^-airf/iuae.cLiirftiSb
The testing is generally conducted on ten or more acres of land or water surface EUPs are
most commonly used for large-scale testing of efficacy and gathering of environmental fate
data' EUPs « P~ ^ Product Managed
FQPA (Food Quality Protection Act) of 1996 Back to Table
Signed into Jaw in August 1996, amended both FIFRA and FFDCA and significantly
furtftTtafls ^^ regulatory system- See http://www.ena .^v/oppfeadl/fapa for
OPP (Office of Pesticide Programs) Back to TOD
S^iV*6^'? ^n *C Environmental Protection Agency responsible for protecting
public health and the environment from the risks posed by pesticides It is also OPP's
responsibility to promote safer means of pest control. OPP and the Office of Pollution
Prevention and Toxics (OPPT) comprise the two offices within the Office of Prevention
Pesticides, and Toxic Substances. OPP is comprised of nine Divisions: Antimicrobials- '
Biological mid Economic Analysis; Biopesticides and Pollution Prevention; Environmental
.-Fate and Effects; Field and External Affairs; Health Effects; Information Rwourceslnd
DirrwD™0"5 Jk8!stra5°n; and Special Review and Registration, http://www.era.gov/resticides
RED (Reregistration Eligibility Decision) Back to Table - /pesuciaes
RED documents summarize the findings of EPA's reregistration review process for individual
chemical cases, and reflect the Agency's decisions on risk assessment and risk management
for the uses of pesticides. Besides summaries of risk assessments, RED documents include
requirements for risk reduction, product-specific data to support product reregistration and
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any additional generic data needed on the active ingredient(s).
Reregistration Back to Table
The reevaluation and relicensing of existing pesticides originally registered prior to 1984. The
purpose of reregistration is to evaluate and approve the older formulations against modem
scientific and regulatory standards. The process is scheduled to be completed on the older
active ingredients by the end of 2002.
Residue Back to Table .
That quantity of pesticide, its degradation products, and/or its metabolites remaining on or in
the soil, plant parts, animal tissues, whole organisms, and surfaces.
Restricted Use Back to Table
A pesticide that is available for purchase ^nd use only by certified pesticide applicators or
persons under their direct supervision. This designation is assigned to a pesticide product
because of its relatively high degree of potential human and/or environmental hazard.
Special Review (SRI Back to Table ;
This is the process through which existing pesticides suspected of posing unreasonable risks to
human health, the environment, or non-target organisms-are referred for review by the .
Administrator or the Assistant Administrator. The review requires intensive risk and benefit
analyses with the opportunity for public comment. If the risk of any pesticide use is found to
outweigh social and economic benefits, regulatory action can be initiated. Regulations
pertaining to Special Review procedures are found at 40 CFR Part 154. Special Review
formerly was known as Rebuttable Presumption Against Registration (RPAR).
Tolerances Back to Table
Maximum permissible levels for pesticide residues allowed in or on commodities for human
food and animal feed. Ufnder the Federal Food, Drug, and Cosmetic Act, EPA is responsible
for establishing tolerances. Whenever a pesticide is registered for use.on a food or feed crop, a
tolerance or exemption from the requirement of a tolerance must be established. Established
tolerances and exemptions for pesticide chemicals in or on raw agricultural commodities are
listed in 40-CFR 180. Tolerances for pesticides in processed food are at 40 CFR 185; and
tolerances for pesticides in processed animal feed are listed at 40 CFR 186. Tolerances are
enforced by the Food and Drug Administration and the U.S. Department of/Agriculture.
USDA iUnited States Department of Agriculture! Back to Table
The Federal Agency responsible for the Food Stamp Program and certain other food and
nutrition programs, the farm commodity programs, the crop insurance program, the
Conservation Reserve Program, rural development, agricultural research and education,
agricultural credit, international food aid, food marketing and inspection, forestry, and certain
nutrition programs, http://www.usda.gov/
Table Introduction I OPP Home I EPA' Home I Comments •
Site Map I Search OPP 1 Search EPA
www.epa.gov/pesticides/carlist/table.htm
updated June II, 1998
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