WATER POLLUTION CONTROL RESEARCH SERIES • 18010DPV12/70
  Water  Quality  Criteria Data Book
                Volume I
     Organic Chemical Pollution of Freshwater
ENVIRONMENTAL PROTECTION AGENCY • WATER QUALITY OFFICE

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         WATER POLLUTION COHTROL RESEARCH SERIES
The Water Pollution Control Research Series describes
the results and progress in the control and abatement
of pollution in our Nation's waters.  They provide a
central source of information on the research, develop-
ment, and demonstration activities in the Water Quality
Office, Environmental Protection Agency, through inhouse
research and grants and contracts with Federal, State,
and local agencies, research institutions, and industrial
organizations.

Inquiries pertaining to Water Pollution Control Research
Reports should "be directed to the Head, Project Reports
Office, Environmental Protection Agency, Room 1108,
Washington, B.C.  202*12.

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 Water Quality Criteria Data Book,  Vol. 1


 ORGANIC  CHEMICAL POLLUTION OF FRESHWATER
                   for the



      ENVIRONMEWTAL PROTECTION AGENCY
                                s

           Water Quality Office
                 prepared by


          ARTHUR D. LITTLE, INC.

         CAMBRIDGE, MASSACHUSETTS
             Project #18010 DPV
            Contract # llj-12-538

                December 1970
               442  -963
For sale by the Superintendent of Documents, U.S. Government Printing Office
            Washington, D.C. 20402- Price $3.50
               Stock Number 5501-0144

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                 EPA Review Notice

This report has teen reviewed "by the Water
Quality Office, EPA, and approved for publication.
Approval does not signify that the contents
necessarily reflect the views and policies of
the Environmental Protection Agency, nor does
mention of trade names or commercial products
constitute endorsement or recommendation for
use.
                        ii

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                FOREWORD
The quantity of literature since the
publication of WATER QUALITY CRITERIA,
McKee and Wolfe, Second Edition, 1963,
has "been so great that rather than a
revision, the Environmental Protection
Agency is publishing, as its successor,
a series of volumes under the general
title, WATER QUALITY CRITERIA DATA
BOOK.  This series is the Environmental
Protection Agency's response to
California State Water Resources Control
Board Resolution, No. 69-! titled,
"Requesting the Federal Water Pollution
Control Administration to Assume
Responsibility for Conducting Further
Work on the Publication Titled  'Water
Quality Criteria1."  The Federal Water
Quality Administration was asked to give
reconsideration to assuming the
responsibility for the continuance of
summarizing and referencing worldwide
literature on water quality criteria.

Volume I, "Organic^Pollution of Fresh-
water," is the first in the series.
Volume II, "Inorganic Chemical  Pollution,"
is scheduled for publication late 1971;
Volume III, "Effects of Industrial
Chemicals on Aquatic Life," early
summer 1971; Volume IV, "Recreational
Water Quality Criteria," early  autumn
1971.

Subsequent volumes will "be announced at a
later date.
                   iii

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                     TABLE OF CONTENTS









                                                       Page




   I.   SUMMARY                                           1




  II.   INTRODUCTION                                      3




 III.   METHODS AND APPROACH                              9




  IV.   RESULTS                                          21




   V.   QUALITY CRITERIA                                 37




  VI.   TABLES                                           49




 VII.   REFERENCES                                      327




VIII.   INDEX                                           369
                             iv

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                               LIST OF TABLES
Number                                                                 Page

   I.         Concentration of Organic Pollutants Looked For and
             Found in Fresh Water                                        49

  II.         Mammalian Acute and Chronic Toxicity of Organic
             Pollutants Found in Fresh Water                            126

 III.         Mammalian Acute and Chronic Toxicity of Potential
             Organic Pollutants of Fresh Water                          152

  IV.         Concentration and Effects of Organic Pollutants in
             Human and Animal Tissue                                    249

   V.         Carcinogenicity in Mammals of Organic Pollutants Found
             in Fresh Water Examined by the Oral Route of Adminis-
             tration                                                    264

  Va.         Carcinogenicity in Mammals of Organic Pollutants Found
             in Fresh Water Examined Only by Routes of Administra-
             tion Other Than Oral                                       271

  VI.         Carcinogenicity in Mammals of Potential Organic
             Pollutants of Fresh Water Examined by the Oral Routes
             of Administration         ,                                 272

 Via.         Carcinogenicity in Mammals of Potential Organic
             Pollutants of Fresh Water Examined Only by Routes of
             Administration Other Than Oral                             281

 VII.         Mutagenicity and Teratogenicity of Organic Pollutants
             Found in Fresh Water in Humans, Animals, and Plants        284

VIII.         Mutagenicity and Teratogenicity of Potential Organic
             Pollutants of Fresh Water in Humans, Animals, and Plants   288

  IX.         Sources of Organic Pollutants Found in Fresh Water         295

   X.         Sources of Potential Organic Pollutants of Fresh Water     298

  XI.         Reported Maximum Concentration of Organic Chemicals
             Found in Fresh Water Producing No Effect in Mammals
             When Administered on a Chronic Basis or Tested for
             Organoleptic Effects in Man                                303

 XII.         Acute Toxicity Ranking of Organic Chemicals Found in
             Fresh Water as Determined by LDso in Mammals Using Oral
             Administration                                             317

XIII.         Acute Toxicity Ranking of Potential Organic Pollutants of
             Water as Determined by LD5Q in Mammals Using Oral Admin-
             istration                                                  319

 XIV.        Ranking of Reported Threshold Doses Obtained by Chronic
             Administration in Rats                                     325

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I.   SUMMARY






    A survey of  the available literature on organic chemical  pollu-




    tion of fresh water showed that 496 organic chemicals  have  been




    reported to  be found or are suspected to be in fresh water.   Of




    these,  66 have been identified.  The informational and scienti-




    fic quality  of the literature are not of a high order.  As  might




    be expected, evidence which directly relates the presence of  or-




    ganic chemicals in fresh water with human health is generally




    lacking.







    Industrial sources were responsible for the largest number  and




    variety of structural types of organic chemical pollutants.   Re-




    ported agricultural sources of pollutants were all pesticides




    and domestic sources were all detergents.  Animal toxicity




    information  was available on all compounds in one form or an-




    other,  but consisted mainly of acute toxicity data. Most of




    the limited  chronic animal toxicity information pertinent to




    the problem  of organic chemical pollution of fresh water  and




    human health came from Russian sources.  These results were




    used directly by the Russian investigators as quality  criteria




    for humans.   Pesticides were shown to be the most acutely toxic




    organic chemicals in water and only methyl mercuric chloride




    was found to be more toxic.  Although the information  on  chronic




    threshold doses was insufficient for meaningful interpretation,




    the organometallies ranked high in chronic toxicity effects.

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Of 120 compounds examined for carcinogenicity in animals, 22.5




percent were positive.  Of 32 compounds examined for teratogeni-




city in animals, 62.5 percent were positive.  It would appear




that methyl mercuric chloride has been found to be teratogenic




in man.  Although there is no proven chemical mutagen for man,




of 29 compounds examined for mutagenicity, mostly in plant cell




systems, all showed some effects on genetic material.  High con-




centrations of certain compounds (mostly pesticides) were shown




to be present in the tissues of animals and man.  Some of these




have been reported to be potential carcinogens, teratogens or




mutagens.  The available data on pesticides are predominantly




American and on non-pesticide compounds predominantly Russian.








This survey has shown that factual information upon which quality




criteria of water can be rationally based, is generally lacking




for compounds occurring in fresh water.  This is further compli-




cated by the threshold and no-threshold controversy in terms of




potential carcinogenicity and mutagenicity and to a lesser extent




of teratogenicity.  The practical proximate solution will pre-




sumably have to resemble that employed in the radiation area




where some baseline human exposure is unavoidable.

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II.  INTRODUCTION






    Population growth,  increasing demands by this  population, new tech-




    nology,  and a burgeoning industry all contribute to the  overall  in-




    crease in chemical  pollution of fresh water and its potential effects




    as a health hazard.







    The average individual ingests 1 liter of water per day  in  one form




    or another in order to maintain body water requirements  in  the face




    of what has to be excreted for removal of the  wastes of  metabolism.




    This daily intake goes on throughout life and  the maintenance of




    body water is so important that a loss equivalent to more than 5%




    of body weight at any one time seriously affects normal  function.







    Some, if not  most,  of the chemicals we ingest with water on a daily




    basis can produce acute and/or long-term adverse effects on health.




    In the past we have learned how to detect and in large measure to




    control the contamination of water by pathogens.  Just as clear




    water can contain bacteria, so also can clear water contain a host




    of chemical substances,many of which are unidentified, which may




    be deleterious to health.  Just as new knowledge was needed in




    the past to identify and control contamination from microorganisms,




    so is new technology now needed to identify and control chemicals




    in water.







    At one time chemical wastes were in  quantities which could be dis-




    persed efficiently in water.  This situation no longer exists as

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witnessed by the frank polluted condition of many of our rivers




and lakes.  This condition will undoubtedly get worse unless some-




thing is done about it.  Ideally, nothing should be put in water,




b'ut this is unrealistic.  The present techniques of haphazard




dumping of wastes into the nearest watercourse is producing damaging




effects when the wastes reach proportions which cannot be handled




by the watercourse.  The problem is further compounded by sanitary




landfill operations, presently the only means of disposal of trash




in many urban and rural communities, contaminating underground water




resources.  The solution is the formulation of present and new




knowledge into a set of standards which will allow predictions of




the effects of inputs on the system.  In general, water has an in-




herent capacity to deal with pollution but our understanding of the




way it deals with chemical pollution is negligible.  We can predict




in some general way that chemicals will react with other chemicals




in the water and form new compounds which may or may not be harmful,




that organisms will degrade toxic chemicals to more simple and may-




be less toxic compounds and that toxic metals are difficult to change




chemically and difficult to remove from water.  However, few specific




examples are available.







We can probably, in part, physiologically adapt to chemical pollu-




tion in terms of taste, odor, physiological response and perhaps




even cellular response.  This adaptability creates difficulties




in relating the chemical components' of a water  supply  to a health




problem.  It is well known that  local residents find no cause  to

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believe that their water supply can create grastroenteric problems




for newcomers.  However, it can be expected that there is a point




at which no further adaptation can take place and that our health




will be impaired by continuous ingestion of water containing a host




of chemical substances some of which are proven to have carcinogenic,




teratogenic, and mutagenic properties, and others of which can induce




histopathological effects.  These are effects which in most instances




cannot be evidentially related to water.







In order to understand the meaning of chemical pollution of fresh




water, a baseline is needed.  This baseline varies with the intended




use of water.  For instance, water which is adequate for industrial




use may not be acceptable for drinking purposes.  The problem we




are concerned with in chemical pollution and health is water intended




for human consumption which contains  chemicals at concentrations




which can produce harmful effects on  an acute or a chronic basis.




Therefore, the baseline  for a particular chemical would be a con-




centration which we know will not produce  harmful effects.







An aspect of  chemical pollution which should not be neglected  is




that which is concerned  with the accumulation of chemicals in




aquatic food  sources.  This accumulation can be both  direct or




indirect.  In either case  large concentrations of toxic  chemicals




in tissues have been demonstrated.  While  it is to be admitted




that the consumption of  fresh water sources of  food  is small  com-




pared  to the  consumption of water,  this should be considered  as




a potential human health hazard.

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The sources of chemical pollution are multiple and may be classi-




fied as arising from agricultural use (fertilizers and pesticides),




natural sources (leaching of chemicals from geological formations),




industrial manufacturing processes, domestic sources (detergents,




pesticides) and accidental spills.  In this report we are concerned




with those sources which supply a continuous and often increasing




rate of chemicals in water directly by the use of watercourses as




a means of waste removal or indirectly by the purposeful or unintended




use of chemicals in locations which are watersheds.







The supply of naturally occurring fresh water for the use of mankind




is fixed and increasing pollution of water so that it becomes un-




usable, decreases the total quantity available for use for man's




physiological and domestic needs, for industrial purposes, for




recreational pursuits, for aesthetic enjoyment, and for aquatic




life as a food source.







Methods for detecting chemicals in fresh water are technologically




feasible provided that we know what we want to detect and given




time to develop or modify methods and make the necessary determina-




tions.  Our current knowledge of chemicals in water has been entirely




dependent upon the analytical methodology available and chemicals




actually looked for.  As a result the chemical pollution picture




of fresh water is undoubtedly far from complete.  We already know




that certain rivers are replete with a host of chemicals some of




which are known carcinogens, teratogens, and mutagens.  Most of

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these have unknown fates and their toxicity to aquatic life and




terrestrial plants, animals and man are poorly characterized.







Although public health emphasis on food quality has been with us




for sometime, public health concern and action concerning water




quality has not received nearly the same attention despite the




proven presence of chemicals which have visibly changed the bio-




environment so drastically in the past 50 years.  At present,




concern with food quality is centered on trace amounts of pesti-




cides, fertilizers, preservatives, radioactive fission products,




and carcinogens, representatives of which can be found in fresh




water, but which to date have not elicited the same degree of




concern or action.







Currently, municipal waters are treated principally to make them




microbiologically safe for drinking.  Very little is done to make




them chemically safe and it is difficult to factually relate a




human health problem with the chemical condition of our municipal




water supplies.  Since the successful control of communicable




diseases in general and waterborne diseases in particular has in-




creased our average life span, other health problems such as meta-




bolic diseases, cardiovascular diseases, cancer and others have




come to the fore.  Although we consider these as diseases of our




increased average life span, we do not know to what extent pollu-




tion is a contributory etiologic agent.  On the other hand, we




know that carcinogens exist in a proportion of our water supplies




and we cannot assume that they are not contributory to the rate of




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cancer in our society.  Unfortunately, evidence of the relationship




between chemicals in water and the physical ills that beset us is




tenuous.








Americans have become increasingly involved in the area of drug




abuse and the probability of drugs reaching water supplies has in-




creased.  It is recognized that disposal of drugs in the waste




water system is one means of destruction by both police depart-




ments and hospitals.  This specific area of concern was excluded




from consideration in this report.








Although it is difficult to extrapolate animal data to humans, the




use of animals has served us well in the past for assessing the




effects of therapeutic drugs, environmental stresses, psychological




stresses, and chemical agents on man.  The very fact that the bio-




ecology of rivers has been changed by chemical pollution, should




give us food for thought in a rapidly increasing general pollution




problem.  Therefore, in the general absence of human data, this




report principally presents available animal toxicological and patho-




logical data on chemicals actually found or potentially could be




found in water so that some assessment of their effects on man can




be made.
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III.  METHODS AND APPROACH

     1.  Literature  Search

        More  than  7,000 publications,  the  titles of which appeared to
        be pertinent, were  collected and examined.  Of these, approxi-
        mately 1,000 were found  to  have some pertinency and were examined
        more  closely.  Approximately 600 of these were actually found to
        have  information which could be used.  Only those publications
        which presented quantitative data  were considered.  Publications
        which contained pertinent data but which were published or received
        after completion of our  information search are listed separately
        in the bibliography.   In carrying  out  the literature search, the
        following  sources were explored:

        a.  Abstracts  and  Indexes

            Applied Science & Technology                   1960-June  1970
            Abstracts  on Hygiene                          1960-1969
            Bibliography of Agriculture                    1960-1969
            Biological Abstracts                          1960-May 1970
            Chemical Abstracts                            1907-June  1970
            Excerpta Medica, Section 17,  Public  Health,
            Social Medicine and  Hygiene                    1968-1969
            Index  Medicus                               •   1960-June  1970
            Monthly Catalogue U.S.  Government  Publications  1960-March 1970
            Public Health  Engineering Abstracts            1962-1967
            Publications  of the  U.S. Geological  Surveys    1941-1964
            Toxicity Bibliography                         1968-March 1970
            Water  Pollution Abstracts                     1950-February 1970
            Technical  Translations                        1964-July  1967
            University of  Wisconsin Water Resources Center
            Eutrophication Program                        March-July 1969

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b.  Journals

    Air and Water Pollution                                1964-1966
    Archives of Environmental Health (Arch. Ind. Health)   1955-July 1970
    Bulletin of Environmental Contamination and Toxicology 1966-1969
    Food and Cosmetics Toxicology                          1969-1970
    Gigiena i Sanitaria (Hygiene & Sanitation)             1960-Jan. 1970
    Journal of the American Water Works Association        1960-May 1970
    Pesticides Monitoring Journal                          1967-1969
    Toxicology and applied Pharmacology                    1969-1970
    Water Pollution Control Federation Journal             1957-June 1970
    Water Research                                         1967-1969
    Journal of Environmental Health                        1968-March 1970
    WHO Technical Reports                                  1966-1968
    Gesundheits-Ingenieur                                  1968-1969

c.  Books, proceedings of symposia and international conferences,
    bibliographies and citations in review articles.

d.  Once the chemicals which were demonstrated to be in fresh
    water and the chemicals which potentially could be found in
    water were compiled, existing acute and chronic toxicological
    information was searched and extracted.

    Reviews, abstracts, papers and compilations of information
    on carcinogenicity, teratogenicity, and mutagenicity were
    examined for pertinent information.

    Where possible, the more recent information was used in pre-
    ference to information contained in the older literature.
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2.  Quality of Literature






    The quality of the literature searched was not of  a high order




    in terms of the information required for the purpose of  this




    study.  Mich of the literature gave no rationale for why a che-




    mical was selected for study.  Information concerning the origin




    of a pollutant and its geographical location from the point at




    which the sample was taken for study was rarely reported.  Des-




    criptions of the waters being investigated, such as approximate




    width, depth, and velocity, which would give some general idea




    of dilution effects and therefore some idea of the quantities




    at the point of origin were never given.  Interpretation of




    results, their meaning, conclusions, recommendations, and prob-




    able relationships of results to health was rarely discussed  by




    investigators.







    In general toxicity information poorly characterized dose rela-




    tionships.  Therefore, it was difficult to obtain from the data




    the probable  concentrations which would be of  interest for use




    in obtaining  quality criteria.  In  fact, much  of the toxicity




    data, although obtained for the specific purpose of characterizing




    toxicity effects, were not always relevant to  the problem of




    formulating quality criteria.  The  information on carcinogenicity,




    mutagenicity  and  teratogenicity were not,  in  general, studied




    in terms of dose.;response.  In chronic toxicity .studies, including




    carcinogenicity studies, information such as dose, duration,  species




    of animal used and frequency  of administration of doses were not





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   always given.  Frequently doses were expressed in a manner which




   could not be converted to units used in most reports.  The ra-




   tionale  for the doses selected for study were generally lacking.




   A disproportionately large effort was expended on pesticides and




   a disproportionately small amount of effort was put into chemical




   pollution of rivers and lakes as a result of industrial wastes.







   In the United  States, toxicity information were obtained on fish




   or other aquatic organisms of little use for the purpose of this




   study so that  the Russian literature had to be used for toxicity




   information on mammals.  The quality of the Russian literature




   suffered mostly from an absence of information on what was done




   and how  it was done.  Names of researchers were cited with no




   literature references and original works could not be examined.




   In many  cases, the periodicals were not available or translations




   could not be obtained and results had to be taken directly from




   abstracts.  In contrast to information in the English literature,




   the Russians did provide most of the acute and chronic toxicity




   information although their use of this information can be subject




   to criticism.







3.  Information extracted






   Where  available,  the concentrations  of chemicals  in  water were




   obtained together with  information as  to  source  and  location.




   Available information on  chemicals which  for  one reason  or  an-




   other  have not been measured  in water, but have  been considered






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    in the  literature to be  potentially present  in water, was also




    obtained along with information on source.   Included in  this  toxi-




    city data,  information,  where available,  on  duration, dose  response,




    and specific effects were obtained for both  chemicals which have




    been found  in water and  chemicals which have been  considered  to




    be potentially present in water.  Only the oral  route of administra-




    tion was considered for  inclusion.  However, where no oral  data




    is available an alternative route of administration is presented




    and denoted as such.







4.  Chemical Organization of Information







    It was  hoped to use structure activity relationships as  a means




    of predicting the potential toxicity of novel compounds. To  fur-




    ther this end it was necessary to group compounds  on the basis




    of their structural components which might lead  to kindred  toxi-




    city.  Therefore, compounds have been specifically classified




    under 17 major headings.  Within a number of these major chemi-




    cal groupings, sub-groupings exist so that  compounds can be




    compared as to their toxicity and evaluated  for  the  importance




    of various  contributing  constituents to the  toxicity of  these




    compounds.   In this section chemical  structures and their




    importance  as pollutants of fresh water will be  discussed.







    In accord with standard  organic chemical  classification, the




    first category considered was the alkanes and alkenes.   The
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unsubstituted forms of these compounds have low water solubility




and in general a low degree of toxicity.  They can occur in fresh




water as natural pollutants arising from petroleum reserves but




may also appear through their use as a basic material in the petro-




chemical industry or as solvents in numerous processes.







The halogenated alkanes and alkenes, by contrast, are all the re-




sult of chemical synthesis.  By far the majority of these compounds




which have been found in fresh water are chlorinated pesticides




resulting from their use for agricultural purposes.  These com-




pounds have received special notoriety in recent years.  While




these compounds in general have a low solubility, their high




degree of toxicity and resistance to natural degradation make them




of great concern in considering potential human health hazard.  Be-




sides the hydrocarbon pesticides, other more simple halogenated




alkanes and alkenes do exist and also show a resistance to decay,




but these compounds in general are found to be less toxic.  No




nitroalkanes have been found as organic pollutants in water but




some of these are potential pollutants.  However, they make up




a small group of compounds.







The alcohols are among the most soluble of organic compounds in




water.  Many of these compounds (carbohydrates) are natural food




constituents and are of little danger, therefore, in terms of




toxicity.  Others of these compounds, arising from industrial




processes and appearing in fresh water as industrial waste, do




show toxic effects in mammals.  However, in general, the lability





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of these compounds to both air and microbial oxidation gives them a




short lifetime in water.  Enhancement of microbial growth as a result




of the presence of a pollutant would affect dissolved oxygen levels.







The amines are subdivided into different categories because of the




different properties these may have in terms of structure activity




relationships.  The amines show a reasonable solubility in water.




The aliphatic amines are produced by the petro-chemical industry.




A number of these have been found as pollutants in water.  As a




class they show an acute toxicity of less than a gram per kilogram




in mammals.  Many of these compounds have a sufficient vapor pressure




to be rapidly eliminated from water by evaporation.







The aromatic amines with a potential for being present in water are




mostly derivatives of aniline.  These compounds are related to dye




manufacture and use.  On the other hand, quarternary amines are




most widely used and would appear in water because of their appli-




cation as  cationic surfactants.







The nitriles are nitrogen compounds containing the cyano group




which, in  certain cases, can be released as cyanide.  These com-




pounds are both pesticides and have a use  in organic synthesis




in the petro-chemical industry.  According  to the literature,




only one of these compounds has been found  as a pollutant of




fresh water.  Heterocyclic compounds in which nitrogen,  sulphur




or oxygen  is  incorporated into a ring structure with carbon atoms




can occur  as natural breakdown products of  plants or bacteria.




However, it is the use  of such compounds as pesticides and  their





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presence in some industrial wastes which is of more concern in




relation to water pollution.  Since the heterocyclic ring may




serve as the base of many diverse chemical compounds, more diver-




gency in toxicity is apparent in this subgroup.  Thus in this group




we have toxins such as nicotine and strychnine as well as some




herbicides with a low degree of mammalian toxicity.







The carboxylic organic acids can also occur as natural components




of fresh water.  The straight chain acids are found in our own




bodies and the short chain forms are one of the major end products




of bacterial catabolism.  However, another source of these compounds




is their use in industry and the use of the phenoxyalkylacids as




herbicides.  All of these compounds, once diluted in water so as




to limit their specific acidic effect, show a limited toxicity




except in a few occasions where other portions of the molecule




contribute.







The organic sulfates have not been looked for in fresh water. These




compounds are used to some extent as detergents but not to the ex-




tent of the sulfonic acids.  Sulfonics are the major active com-




ponents of detergents and have been widely found as pollutants of




fresh water.  The form in which the major amount of alkylbenzene




sulfonates are presently synthesized allows them to be readily




degraded by microorganisms present in fresh water.







No carboxylic esters have been reported in fresh water.  The labil-




lity to hydrolysis of these compounds would make them nonpersistent.






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Certain of these compounds which are being used as pesticides,




however, do show a high degree of toxicity.







Amides (amine derivatives which are analogous to the esters) also




have not been looked for in fresh water.  Certain of the amides




do have a high toxicity, however.  Of more concern, because of




their greater use as agricultural products, are the carbamates.




Even though they degrade comparatively rapidly, their high acute




toxicity in mammals should elicit some concern.  Of lesser acute




toxicity are the thiocarbamates.  The final amine derivatives in




our listing which are potential pollutants are the ureas.  These




are widely used as herbicides but do not have the acute toxicity




of the carbamates or thiocarbamates.







The phosphate esters are a specific group of compounds which exist




in fresh water solely because of their use as effective pesticides.




They work specifically by inhibiting nerve transmission in both




insects and man (although presumably more effectively in the




former).  They have not been widely reported in fresh water,




probably because of their lability to hydrolysis..







The aldehydes, ketones and ethers are all products of industrial




processes.  A few have been used as pesticides and these specific




compounds, because of other portions of their molecules, can be




of concern toxicologically.  However, these compounds also have




not yet been reported as being present in fresh water.  The group




of compounds as a whole is otherwise generally innocuous.  In






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fresh water these compounds are oxidized to carboxylic acids.







The unsubstituted aromatic compounds are not found at high con-




centrations in fresh water because of their limited solubility.




These compounds can occur naturally in oil wastes or may be the




result of industrial processes.  Because of their limited solu-




bility they present little threat for acute toxicity.  However,




their efficacy in carcinogenesis is well known and, for this




reason, their presence in fresh water should be a matter of con-




cern.







The phenols and quinones are hydroxylated aromatics with increased




water solubility and toxicity.  Some of these compounds arise




from natural sources but most arise from industrial wastes or




through their use as biocides.  Many of these compounds have a




high level of acute toxicity.  A number of them have been dis-




covered as pollutants of fresh water and their concentration in




water is a subject of increasing concern.  Many of these compounds




interact in water with other materials to give less toxic deriva-




tives .







The aromatic derivatives are widely distributed because of their




production as industrial products and wastes or because of their




use in agriculture.  The most well known halogenated aromatic




derivative is DDT.  Compounds such as DDE and DDD are modifica-




tions of this material.  The halogenated aromatic derivatives,




just as the halogenated alkanes and alkenes, are extremely





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persistent in fresh water.  In general, they have a low acute




toxicity but many of the long-term effects of these compounds are




just beginning to be realized.  Because of their low solubility




and, therefore, low concentration in water, they are presumably




of little concern as a problem in drinking water but do become




concentrated through the food chain where their real effect is




felt.  The other aromatic derivatives potentially to be found




in fresh water contain nitro groups or alkyl groups.  These




compounds result from manufacturing processes or from petroleum




wastes.  In general they have a low acute toxicity.







Sulfur compounds which are potential pollutants do not have a




unified mechanism of mammalian toxicity as in some of the other




groupings, but may range  from the lethal compound, mustard gas,




to various mercaptans of  low acute toxicity but high organoleptic




effect.







Many of the organometallics are highly toxic.  On the other




hand, the polymers form a chemical class without any uniform




basis in structure activity relations.  The miscellaneous sur-




factants exhibit toxicity by  alterations  in membrane function.




Other organics are listed in  the  final miscellaneous organic




classification without any reference to structure-activity




relations.
                               19

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5.  Indexing






    In order  to facilitate locating information on any particular




    chemical in this report, we have prepared an alphabetical index




    which consists of names of chemicals as used in this report with




    synonyms, chemical names, trade names, etc.  This is presented




    in Section X.
                                   20

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IV.  RESULTS
     Table I lists the concentrations of organic pollutants that have


     been found in water based on the search of the literature.   The


     chemicals listed in this table as in subsequent tables have been


     characterized and tabulated, where appropriate, by their chemical


     composition described earlier under Section III-4.  The source  of


     the chemical (agricultural pesticide, industrial waste, domestic


     waste,  etc.) is also tabulated for each chemical where this in-


     formation was available.  The location of the sample is tabulated


     under a separate heading, and indicates where the sample was taken


     from.  For a number of chemicals several concentrations found at


     the same location at different times or at different locations


     are indicated where this information was available.





     No attempt was made in searching through the literature to  assess


     the qualitative or quantitative results of the analytical data.


     The techniques used by different investigators, sampling techniques


     and the sensitivity of analytical procedures was not assessed.


     There will no doubt be variations even with the same investigator


     as more sensitive analytical techniques are employed.
                                                       t-




     The greatest proportion of compounds measured in fresh water was


     made up of pesticides.  As pointed out earlier, sources were


     poorly characterized in terms of physical location, distance from


     point of test sample and topographical characteristics which would


     throw some light on the nature of chemical pollution of fresh water.
                                     21

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Where information was available on a sequential time basis, concen-




trations of pesticides varied considerably presumably due either




to times of application of pesticides or to periods of rainfall




run-off or both.  Therefore, pertinent climatological data might




have been helpful in assessing the characteristics of pollution




with agricultural products.  In some intensely agricultural areas,




such as cotton growing areas, concentrations of pesticides in




rivers and municipal water supplies reached relatively high levels.







Concentrations of pesticides in fresh water formed the largest con-




tribution of the U.S. literature while the largest input of in-




dustrial and domestic sources of chemical pollution were obtained




from the foreign literature.  Thus, little information on industrial




chemical pollution in the U.S. is available.







Table II presents acute and chronic toxicological information on




chemicals presented in Table I.  LDc0 is the dose at which 50% of




the animals die.  TLm designates the Median Tolerance Limit which




is the concentration which kills 50% of fish for the indicated




time in hours.  LC50 is the concentration at which 50% of fish




die in 24 hours.  TLm and LCS_ were exclusively obtained on fish.




LD_n formed the highest proportion of the acute toxicity information




available and was exclusively for non-aquatic animals.  Included




under the LD,-n column was data available on humans where fatali-




ties can occur and are estimates only and are essentially LD-inn




data.  As stated earlier, all doses are oral unless otherwise




indicated if oral information was not available.





                              22

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It will be noted that large gaps of information exist for chronic




toxicity and the greatest proportion of the toxicological data




presented in this table comes from the Russian literature.  The




doses presented for chronic toxicity are those which elicited an




effect and where this was not available the doses used are presented.




The chronic toxicity effects varied according to what was looked for.




The Russian data included changes in conditioned behavior and in-




sufficient information was presented in order to determine exactly




how this was done.  Other doses which may have been presented in




the literature,but were excluded from this table are presented in




the Quality Criteria Section because of the presumed relevancy to




the problem associated with arriving at quality criteria.







Table III presents acute and chronic toxicity of potential organic




pollutants of fresh water.  This table is in all details similar




to Table II with, however, the inclusion of sources.  These chemi-




cals are suspected to be in water because of their use for in-




dustrial, agricultural, and domestic purposes or because they are




known to be involved in manufacturing processes the waste products




of which are likely to be discharged into fresh water.  This listing




is probably incomplete but what is available involves a far greater




number of chemicals than those which have been measured in water




indicating that available factual information on chemicals in




water gives an  incomplete story of the total picture.  Again, as




with Table II,  there are gaps in our knowledge of both acute and




chronic toxicity  information.  The human data, though inadequate,




are somewhat more meaningful than those presented in Table II.



                                23

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Table IV presents the available information of chemicals the con-




centrations and effects of which have been examined in tissues.




It will be noted that all information contained in this table




refers to pesticides.  In general, the data indicate that pesti-




cides can be stored in the tissues of humans normally exposed to




them.  As a result of accidental exposure, deaths have occurred




and large concentrations of these pesticides were found in tissue.




Sequential data, where this was available, showed that some pesti-




cides had increasing concentrations in body fat with time in the




U.S. and Indian population but not in the English or in some




cases in the French population, indicating that use of the pesti-




cides in question had increased in the U.S. and India during the




periods of study and had decreased or remained steady in countries




like England and France.  However, the possibility that these




pesticides were accumulating over the period of study without any




change in usage should not be excluded.  The information in this




table also appears to show that storage occurred in all animals




studied.  In general, the studies dealt poorly with characteristics




of human population studied in terms of relative exposure potential.




However, a few studies did give information of this nature and




showed that concentrations in tissues were related to degree of




exposure.  In like manner, information on animal tissues showed




extremely high tissue concentrations in animals living in highly




pesticide treated areas.  Data on aquatic animals generally indi-




cated low concentrations as compared to man and terrestial animals,




presumably because of the generally low concentration of pesticides






                                24

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in water as shown in Table I.  In general, high concentrations




of pesticides in tissues, at least of DDT, were found in India




and Israel.  Studies on storage of DDT as a function of dose




ingested for a period of 12 and 18 months indicate that below




0.0034 mg/kg/day storage does not take place while doses higher




than this show storage to be proportional to dosage.







Tables V and VI present the available information on the carci-




nogenicity of chemicals which have been found in water (Table I)




and chemicals which could potentially be present in water




(Table III).  Most of the carcinogenicity information was ob-




tained from books which summarize the available data on carci-




nogenicity of chemicals in general.  By far the greatest major-




ity  of studies reported results on a few animals only and a




few studies attempted to show a dose-response relationship.




These tables include data obtained by oral administration and




where this is not available, the results from other routes of




administration are given in Tables Va and Via. The dosage forms




used varied considerably.  Some were given in the diet and,




therefore, the amount of chemical in terms of body weight can-




not be computed without knowledge of food intake and weight of




animals.  In other instances, the oral dose was available as




mg/kg of body weight.  The incidence of appearance of tumors




in many cases is not available and results are denoted only
                               25

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 as positives.  The results appear to be different depending




 upon the species of animals studied with mice giving the highest




 proportion of positives.  Presumably many of the studies used




 mice selected for their susceptibility to tumor formation.  In




 some studies there was a high incidence of tumor formation in




 rats used as controls.







 Of the 66 chemicals the concentrations of which have been measured




 in water,'33 have been examined for carcinogenicity and of these




 15 or approximately 45 percent were found to be positive in




 one or more animal tests.  Of the 430 potential pollutants, 87




 have been examined for carcinogenicity and 17 or approximately




 20 percent were found to be potentially positive carcinogenic




 agents.







 Tables VII and VIII present available information with more or




 less pertinency to mutagenicity and teratogenicity of chemicals




. measured in water and chemicals which potentially could be pre-




 sent in water.   In considering presumptive tests for mutageni-




 city,  caution is necessary in interpreting the results.  It




 can be seen from the tables that a variety of test systems have




 been employed.   Although these tell us different things about the




 mutagen and the nature of mutation, it should be remembered that




 most are of little reliability in terms of extrapolating to




 man.   Further reservations with respect to pesticides (which




 constitute  a large proportion of the compounds considered here)
                              26

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were expressed by others (337):"Although we can point to no




pesticide now in wide use that has been demonstrated to be muta-




genic, the overwhelming majority have, however, not been ade-




quately tested, although appropriate methodologies are now




available."  Except in 11 instances in Tables VII and VIII,




all the data relating to mutagenicity or chromosomal effects




were obtained on plants or fungi.  Of the 11 exceptions, 4 were




obtained on human cells in culture, 6 on mice, 1 on the kan-




garoo rat, and 1 on the fruit fly.  Of the 29 chemicals examined,




all showed positive results in one form or another.  Plant




tissues were exposed to the agent usually by soaking in high




concentrations, but duration of exposure was not available




for these and the frequency and duration of dosage for the




animal and human studies were not available or applicable.








The teratogenicity information was obtained on•32 chemicals




and positive results were obtained on 29, and only 1 of these




was obtained on humans while the rest were examined in mammals




and the chick.  The latter is often considered to be an overly




sensitive system.  The frequency and duration of these doses




were not reported.  The  one human study  concerned methyl




mercury  chloride and exposure was through eating contaminated




fish.  Teratogenic effects were seen in  this  instance.
                              27

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Factors to be considered in assessing Toxicity Data









1.  Chemical Interaction







    The fate of active chemicals within the environment is im-




    portant in assessing their ultimate toxicity.   The reactions




    which are usually involved in the alteration of chemical spe-




    cies introduced into the biosphere are often quite simple and




    can be easily predicted, such as hydrolysis, air oxidation,




    and changes brought about by UV irradiation.  Irradiation,




    for instance, converts dieldrin to photodieldrin, a compound




    with four times greater toxicity.  The ability to predict




    the product of such reactions and to evaluate the toxicity




    of the resulting materials is possible because the water,




    air, and light necessary for these reactions are known parts




    of the biosphere.  However, more complex interactions are




    possible which are not easily predictable.







    It has recently been found that the two anilide herbicides, pro-




    panil and solan, are capable of interacting in the soil to yield




    an asymmetric azobenzene (22).  The presence of this new and
                              28

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   potentially toxic agent is dependent upon the high concentration




   of both propanil and solan available for degradation and subse-




   quent reaction.  This example illustrates the importance of having




   a thorough knowledge of the individual components involved in any




   chemical pollution situation before it can be stated that such




   chemicals are not present in the water at concentrations which




   may cause toxic symptoms.  The extent and importance of such




   molecular interaction has not yet begun to be either appreciated




   or evaluated.  Furthermore, the presence of  interacting compounds,




   as with any chemical pollutant, can only be  suspected until tests




   for their detection are available and used.







2.  Microbial Decomposition






   The molecular  structure of almost all pollutants can be altered




   by the action  of microorganisms.  Such bacterial action is the




   basis of sewage  treatment and  is  the major mechanism by which




    detoxification of  our natural waters  is  effected.   Structures,




   no matter how  complex, can be metabolized by the concerted




    action of various  microbial  species  to  inorganic compounds




    (C0?, NH_, H2S)  and  the  structural  elements  of  the  organisms




    themselves  (polysaccharides,proteins, lipids, nucleic  acids,




    and  the  subunits  of  these macromolecules).   Such  structural




    elements  themselves  become  part  of  the water's  chemical milieu




    when the microorganisms  die  and  disassociate.







    The decomposition of any complex compound to inorganic end






                                  29

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    products is a dynamic process.   It  is  uncommon for  one  organism




    to degrade fully any complex molecule  intracellularly.  Rather,




    individual species will usually effect a single oxidation,  dechlo-




    rination, demethylation, hydrolysis, etc.,  converting a known ma-




    terial into one of many new compounds.  For instance, depending




    on the species of microorganism present, even a resistant  chemical




    like DDT (l,l-bis(p-chlorophenyl)-2,2,2-trichloroethane) may be




    converted to DDE (200), DDD, DDA, and  a dicofol-like compound.




    Other acidic metabolites may also be formed (305).







    It is often difficult to predict the compounds which will  or will




    not be produced by microbial degradation.  Of the  20 microorgan-




    isms capable of degrading DDT in the second study  above, none




    produced DDE.  Because of this, it  is  unrealistic  to confine




    one's attention solely to known parent compounds in natural




    waters when assuredly the bacterial flora in the microenvironment




    will have produced a spectrum of metabolites, all  of which may




    have their own toxicological properties.  However,  the  data




    available does not allow an evaluation of the impact of chemical




    pollution beyond parent compounds.







3.  Solubility






    Many of the pollutant compounds which  have been measured  for




    acute and chronic toxicity have limited solubility in water.




    This may have led to errors in the  past in arriving at  L°CQ




    values for such materials, especially  for those measured  using
                                 30

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    aquatic test animals such as fish.   It has only recently been




    realized that the inconsistencies in the tolerance of  fish to




    chlorinated pesticides have been due to the adsorption of  these




    compounds to the walls of test containers, making them unavailable




    to the fish.  The toxicity of such compounds may then  vary with




    the material out of which the test  container is constructed.




    This leads to errors in the data, in addition to those caused




    by such earlier recognized problems as loss by vaporization and




    hydrolysis during the course of the study.







    In the natural state, chlorinated pesticides have been found




    adsorbed to microparticulates in suspension in fresh water.  The




    presence of these toxic compounds in a colloidal state both de-




    creases the reliability of determinations of their concentration




    in water, and provides a reservoir  of such compounds which may




    dissociate back into the water system with time and decreased




    soluble concentration.  The distribution of compounds  on micro-




    particulates may vary.  Certain molecules may be adsorbed  to




    inorganic colloids, while others may be associated with detritus




    and microorganisms.  In addition, the presence of detergents in




    the water supply may alter the distribution of such1compounds




    between the soluble phase and an adsorbed phase.







4.   Analytical Accuracy






    In an evaluation of this type the presence of a highly toxic




    material in low concentration is more important than the exact







                                   31

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concentration of an inert material.  Thus, it is essential that




the analytical methods used be accurate.  For instance, the liver




toxicity associated with halothane is thought to be due to a




0.02% contamination by dichlorohexafluorobutene (65).  The tera-




togenic effect of 2,4,5-T herbicide is even now in question be-




cause of the presence of active impurities in the samples tested




(142).







Some of the analytical methods used in evaluating water quality




are poorly applicable to the generation of data relevant to a




toxicological evaluation.  Atomic absorption spectroscopy indicates




the concentration of elements but not their form.   Thus, for




example, it does not differentiate between metallic mercury,




mercuric ion, and organomercurials, all of which have differing




toxicities (306).







Those analytical methods which depend upon separatory methods for




identification (TLC, GLC, liquid chromatography) are likely to




miss or misidentify compounds with migration characteristics




similar to expected compounds or compounds present in high con-




centration.  The sensitivity of read out with these methods is




also a source of error.  Many highly toxic substances present




in low concentration can be overlooked as a result of such con-




siderations.







Then, too, certain analytical tests are designed to measure only




a particular functional group and we find values in the literature






                             •32

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    for "phenol concentration".   While biologically-derived  phenols




    are generally innocuous,  most industrially produced  phenols do




    show some toxicity which  varies with the compound  tested.  The




    same is  true within any organic series.







5.   Chemical Homogeneity






    The literature contains data for both the toxicity and concen-




    tration  in water sources  of  alkyl benzene sulfonates.  While  it




    is probably reasonable to correlate the  two kinds  of data  in




    order to arrive at an estimate of the potential toxicity of




    such water sources, it should be realised that such  a correla-




    tion is  imprecise.  Alkyl benzene sulfonate is a mixture of




    numerous similar compounds as are many industrial  chemicals.




    Thus it  is never certain  that the chemical composition of  a




    batch which was used for  toxicity testing is the same as that




    found in fresh, natural water.







    Commercial DDT contains less than 80% of the p,p-bis(dichlo-




    rophenyl)-tri-chloroethane.   Most of the remainder is the  o ,p-




    isomer with a significant amount of ODD  being present.   Toxi-




    city studies on such a compound would probably be  performed




    using a  homegeneous analytical grade of  DDT, yet this compound




    would never be introduced into the environment in  such a form.




    This fact, too, decreases the reliability of correlating toxi-




    city data with water concentration data  for a compound.
                                 33

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6.  Altered Metabolism






    The interaction of multiple pollutants within the test organism




    or within man is probably of greater importance in invalidating




    toxicological correlations than the chemical interactions occurring




    within the water system.  The presence of one compound can entirely




    change the physiological disposition of another.   Parathion,  para-




    oxon and sumithion all interfere with the catabolism of propanil




    and thus cause the latter compound to show increased toxicity.




    A more important and commoner effect is the induction of liver




    enzyme systems, especially microsomal enzymes, which catalyze




    the more  rapid degradation of coranon pollutants once induced.




    Thus the LDsn values obtained in single dose toxicity studies




    may bear no resemblance to the LD50 values one would find in an




    animal in which these metabolic enzymes had been increased by




    prior treatment with the same material or related materials.




    This effect is most important in relating toxicity to the real




    world where a continued input of drugs and foreign compounds




    through ingestion and possibly inhalation may cause these cata-




    bolic enzyme systems to exist continually in a more induced state.







    Similarly, the increasing use of pesticidal synergists may greatly




    alter the toxicity of compounds with which they find themselves




    in association.  The synergistic toxicity of a variety of actual




    and potential pollutants should be considered.  The pyrethrum




    synergists, for instance, inhibit the microsomal oxygenase system




    in the insect.  As such, they are important in preventing the






                                 34

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    rapid biodegradation in vivo of insecticides.  However,  such




    synergists may also prevent a similar degradation in man of a




    wide variety of organic compounds and hence cause increased




    toxicity.







Sources






Tables IX and X present chemicals which have been found in water




(Table IX) and chemicals which could potentially be found in water




(Table X) according to sources as given in the literature.  The sources




are ranked in accordance with the number of chemicals originating from




each source and are categorized into three groups, namely industrial,




agricultural and domestic.  In the industrial category the sources which




were defined as industrial without reference to  the specific indus -




try are listed separately.  Since Table IX represents chemicals which




have been measured in water on a more or less randomized basis, the




number of chemicals originating from a particular  source is a matter




of chance rather than a matter of the contribution of a  source  to




the total water pollution  problem.   On the other hand, Table X  lists




chemicals which could be present in  water and, therefore, to some




extent reflect the contribution of a source  to the total problem of




water pollution at least in terms of number  of chemicals but not




necessarily in terms of  the health aspects of chemical  pollution of




water.  Taking the two  tables  together we find that  in  the  industrial




category  chemical  plants contribute  the  highest  number  of chemicals




which have been actually found or  could  potentially  be  found in fresh




water and exceeds  any  other industrial source  by at  least a factor of  2.





                                 35

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The agricultural source of pollution is one of pesticides, while




domestic sources of pollution consist of detergents.  In terms of




numbers of chemicals as well as classes of compounds, chemicals of




industrial origin contribute to fresh water pollution to a greater




extent than those originating from agricultural or domestic sources.
                                  36

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V.  QUALITY CRITERIA







    From the health point of view, chemical quality criteria of water




    should be based on concentrations of chemicals which,  when exceeded,




    is likely to produce physiologic, toxicologic, histopathologic,  car-




    cinogenic, teratogenic, mutagenic and any other undesirable effects.




    Any of these can be considered to be health limiting indices.   Al-




    though organoleptic effects are undesirable, they may not strictly




    be considered to have a health effect if threshold concentrations




    are below those indicating a demonstrable health effect as broadly




    defined above.  However, this approach deals only with chemicals




    as entities in water and disregards the products of interactions




    between chemicals in water and alterations brought about by or-




    ganisms and environmental factors.  In addition, it ignores the




    synergistic biologic effects of chemicals acting in combination.







    If we accept the premise that quality criteria should be based on




    the maximum ineffective concentration, then it would appear that




    the most important information we require for each chemical in




    water is that pertaining to the maximum concentration which can be




    shown to have no health effects in humans.  Obviously, this cannot




    be obtained in a practical manner using humans except by epidemic-




    logical studies which, because of the variety of chemicals in water




    and the generally polluted condition of our environment together




    with adaptive compensations, cannot be expected to be fruitful in




    terms of specific information on some chemicals.  This epidemiolo-




    gical approach in some instances has borne fruit and should not be





                                   •37

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eliminated from consideration.  The beneficial (<8 ppm) and harm-




ful concentrations (>10 ppm) of fluoride were demonstrated using




this approach and undoubtedly it should be considered as being




useful for assessing the effects of chemicals which are not easily




altered in water and for which there are specific demonstrable




effects.  In general, however, we must resort to animal studies




to obtain the necessary information but must consider the attendant




problems of extrapolation to human effects.







Except for the Russian literature, the basis upon which different




countries arrive at quality criteria is not clear.  Publications




which purport to discuss the rationale for arriving at quality




criteria present generalizations which are of little value (70,




82, 109, 145, 146, 162, 163, 171, 172,•326, 327,-391,•398, 446).




The Russians arrive at suggested maximum permissible concentrations




by examination of three factors:






          •  Organoleptic thresholds using human subjects




          •  Biochemical oxygen demand




          •  Toxicological effects from acute, medium, and long-




             term animal studies






With this approach the lowest oral maximum ineffective dose obtained




for the parameters examined and animal species tested is used as




the MFC after direct conversion to mg/1.







Generally, their toxicological studies are carried out in one or




more of 4 species, namely mice, rats,  guinea  pigs, and rabbits





                               •38

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using the oral route of administration.  From the acute studies,




LD__ and acute toxic effects are determined.  Chronic effects are




examined in medium-term studies (1-2 months) and are further studied




in long-term studies covering a period ranging from 5 to 8 months.




From the data obtained, the suggested MFC is generally but not al-




ways based on the highest dose examined which does not induce an




effect in either of the three factors studied.  If we examine




the table (Table XI) of reported maximum no-effect concentrations,




we find that organoleptic effects form the highest proportion




of cases.  This general approach initiated by Cherkinskii (55,




59, 61) does not take into account effects which may be even more




limiting, i.e. carcinogenicity, mutagenicity and teratogenicity.




In addition, it is erroneous to assume that the highest dose which




does not produce toxicological effects for the species of animals




used is directly applicable to man.  It may or may not be and a




safety factor is undoubtedly desirable.







Within recent years we have increasingly recognized the importance




of carcinogenic, teratogenic, and mutagenic effects of pharmaceu-




tical agents and chemicals used as food additives.  Tables V, VI,




VII and VIII show that many of the chemicals which are found in




water or potentially could be present in water are carcinogenic,




teratogenic and/or mutagenic.  To date these data have not been




used systematically as limiting indices although food additives




with carcinogenic properties are banned from use.  Because of




our daily physiological need for water, we are in much greater




danger from the presence of these chemicals in water.




                               39

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How carcinogenicity, mutagenicity and teratogeniclty data can be




used for setting water quality criteria is a question of some




concern.  Current regulations totally prohibit the addition of




carcinogenic substances to foods regardless of how carcinogeni-




city was demonstrated in animals.  At the time this report was




written, the reasonability of this approach is being questioned




and the alternative approach of a threshold dose is favored by




some.  However, as can be seen in Tables V and VI, evidence




upon which the threshold approach to the question of carcinogens




in water can be rationally considered is generally lacking.







An approach which prohibits the presence of carcinogenic chemicals




in water is probably impractical and water quality criteria based




on carcinogenicity may have to be resolved using the threshold




approach.  However, better information than is currently available




will need to be obtained because currently available data are in-




sufficient for the purposes of arriving at threshold doses.







Although no precedent  exists upon which quality criteria of water




can be based for teratogenicity and mutagenicity, the same questions




and lack of data apply.







Information required specifically for use in arriving at quality




criteria for water should be obtained by the oral route of admi-




nistration.
                               40

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On the basis of the information available, the most useful data




for arriving at permissible concentrations are those obtained




from chronic toxicity studies.  However, acute tcxicity data is




useful for determining relative toxicity and for arriving at doses




for chronic toxicity.







The information obtained from animal studies needs to be assessed




in terms of arriving at a basis for permissible concentrations




for humans.  In this respect the limiting index selected will be




the lowest maximum ineffective dose found for all the parameters




examined and animal species studied.  This, however, can only be




used as a starting point.







The applicability of animal toxicity information for predictions




of toxic effects in man can vary considerably depending upon the




compound and the choice of species.  It is readily apparent that




the choice of an insect to determine the toxicity of an organo-




phosphate in man would be absurd.  The organophosphates are use-




ful as selective insecticides because of the differential meta-




bolic rate of these compounds between insects and higher forms




of life.  However, even among the chordates, great differences




in toxicity of specific compounds are apparent.  Rotenone is very




toxic to fish; warfarin is selectively toxic to Norway rats and




mice.  An extreme  example is  the compound norbormide which shows




no toxicity at 1,000 mg/kg in mice, cats, dogs, sheep, swine, or




primates but has an oral LD5Q of about 10 mg/kg in the Norway rat
                                41

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A number of approaches to the problem of gaining information re-




lating to the possible harmful effects of a compound using model




species has been used.  Attempts to obtain data which could more




easily and effectively be applied to human beings using monkeys




as experimental animals in toxicity studies have been made.  It




has been shown quite often, however, that although the monkey is




a close phylogenetic relative of man, its metabolism quite often




is not related.  In a recent study of 23 anticancer drugs (358)




it was found that the monkey was a predictor for organ-specific




toxicity in man only 5 out of 8 times on the average.  When dogs




were included predictions were improved.







Attempts have been made to select a species which simulates man




most closely in the absorption, distribution, metabolism and ex-




cretion of a compound and its metabolites.  This is usually per-




formed by giving the compound to a number of different species




and selecting the one which simulates man most in its response




and metabolism.  This, of course, requires prior knowledge of the




action and metabolism of the compound in man and although this




approach is useful for screening a variety of chemically related




compounds for pharmaceutical purposes, it may not be applicable




for use in the wide variety of chemical species found in water.







Another attempt to obtain toxicological information which is




applicable to man is the use of tissue culture techniques.  These




techniques involve the growing of human and animal cells outside




of the body in chemically defined media.  The advantages of this






                                42

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method are: the low cost of the technique, the fact that less com-


pound is required, the ability to use cells of human origin, the


establishment of reliable controls and the creation of exact con-


ditions of concentration and local environment.  Although this


method holds great promise, the results obtained often do not corre-


late with clinical findings.  By observing only the component parts


of a complex system, one may miss effects which can be seen only


with the whole system.  The form and the concentration of an active


compound which a cell is exposed to by the tissue culture approach


may bear no resemblance to what that same cell may be exposed to


within the living organism.





The Russians have faced this problem as applied to chemical pollu-


tants of water (59) by administering the chemical to a number of
                                  /•

animal species and selecting the species which proved to be most


sensitive for more extensive study using a variety of parameters


which involve a great deal of time and effort.





The foregoing serves as examples of the difficulties involved in


using animal data for prediction of effects  of chemicals in man


and the problems involved  in the toxicological evaluation of po-


tentially harmful pollutants remain large.




Finally, the interaction of multiple compounds remains  to be de-


termined.  As mentioned elsewhere  in this report,  the toxic ef-


fects evidenced when a person is brought  into contact with one
                                43

-------
chemical entity within a short time after having been exposed to




another may often be dramatically dissimilar to those evoked by




either chemical alone.  The type of analysis of the potential




toxicological behavior of compounds present in fresh water pre-




sented in this report appears inadequate in relation to all these




problems, but without extensive experimental programs, it is the




best that can be performed in our current state of knowledge.







The exact means by which animal data can be used to arrive at




permissible criteria will probably continue to be based on the




availability of factual information combined with the best




expert opinion and a reasonable inclination to err on the safe




side.  The Russian approach of directly applying the maximum




ineffective concentration obtained in animals to man is not to




be recommended.







With the above considerations in mind the available information




on suggested maximum permissible criteria and information that




can be used for arriving at permissible criteria can be examined




for pertinency and usefulness.







Table XI presents reported maximum concentrations of organic




chemicals which produce no effect when administered chronically




or when tested for organoleptic effects in man.  It will be




noted that except in a few instances the sources for the in-




formation in this table are from Russian literature.
                               44

-------
Approximately 80% of the data is derived from organoleptic ef-




fects using human subjects.  In other words, the organoleptic




threshold was found to be lower than either the biochemical




oxygen demand doses or the maximum ineffective dose in toxicolo-



gical animal studies.







Table XII presents the ranking of acute toxicity based on LDS




data and show that the chlorinated hydrocarbons are outstanding




in terms of their intense acute toxicity as measured by ID




in mammals.  Since these compounds have all been found to be




present in fresh water, it becomes of especial concern to




direct our attention to them.  Of the six compounds found to




have an oral LD   of 1-100 mg/kg, five of these compounds are




chlorinated hydrocarbons.  More specifically, endrin, isodrin,




aldrin, endosulfan and toxaphene can be considered to be all




derivatives of norbornene.  It is interesting that, except




for methyl mercuric chloride, the most toxic compounds now




found in fresh water should all have the same basic chemical




nucleus.







Heptachlor, the ninth entry in this ordered list, and 'chlordane




also have the same chlorinated norbornene nucleus.  Aside from




these compounds, however, the other most highly acute toxic com-




pounds do not share common structural features.  Most of them do
                               45

-------
contain chlorine atoms, however.  Thus, within those compounds that




have a reasonably high toxicity (100-200 mg/kg LD50) in addition




to those compounds already mentioned, can be seen three hexachloro-




cyclohexanes (lindane and BHC); two forms of a chlorinated phenol;




the organometallic methyl mercury compounds; the chlorinated dia-




ry lalkanes, DDT and DDD; two simple amines; a benzonitrile; an




organic phosphate (Def); and two chlorinated phenoxyacetic acids




(2,4,5-T and 2,4-D).







Examination of the rest of the list reveals similar compounds:




amines (some organic), another phenoxycarboxylic acid, another




organic phosphate, another chlorinated diarylakane and a number




of phenolic compounds.  The only new group of compounds present




toward the latter part of this list is the surfactant family




represented by different forms of alkyl benzene sulfonates.







A different picture presents itself among those organic compounds




considered potential pollutants of fresh water which have not yet




been reported to be present in fresh water and which are listed




in Table XIII. Because of their greater number, it is probably




best to turn our attention first to those compounds having an




oral LDcQ value of less than 10 mg/kg.  Among this group of 23




compounds, 15 are phosphate esters.  While the substituent groups




may differ among these 15 compounds, it may be assumed that it is




the phosphate ester constituent itself which is responsible for




the high toxicity.  The remaining eight compounds are substituted
                               46

-------
pyridines (nicotine and picoline); carbamates (Isolan and Temik);




the substituted indanedione anticoagulant, diphacinone; acrolein;




the organometallic, tetraethyltin; and acetone cyanohydrin (which




is toxic due to the fact that it releases hydrogen cyanide).







Among the remaining compounds with an acute toxicity of 1-100 mg/kg,




the organophosphorus compounds again make up the largest grouping,




with 20 pesticides falling within this category.  No other simi-




larly large group is found.  Seven of these remaining compounds




are carbamates, five are phenols and four contain the nitrile group.




The ability of the organic phosphate esters and of the carbamates,




for instance, to rapidly hydrolyze in water, may prevent the accu-




mulation of high concentrations of these materials in fresh water




and so decrease the pollution hazard of these compounds.








It is apparent from the relatively small  size of Table XIV that




little has been published on the  chronic  threshold doses of com-




pounds which may appear in fresh water.   All of the data presented




in this table are from the Russian literature and include threshold




doses resulting from changes in  conditioned reflex behavior.  Most




noticeable is the absence of pesticides from this table.  Those




which have been investigated, such as carbothione and simazine,




are found to have a low ranking  in terms  of threshold  dose.




Most of the other compounds in the table  are common organics




which share little in terms of structural similarity.  Extrapola-




tions from this meager data is impossible because it is diffi-




cult to judge how much the presence of data on  a functional





                               47

-------
chemical group is due to investigator interest or how much it is




due to lack of investigation of other compounds.







The most noteworthy feature of Table XIV is the presence of the




three organometallic compounds, tetraethyl tin, ethyl mercuric




chloride, and diethyl mercury at the top of the listing.  The




next compound in the list has a 50-fold higher threshold dose




than the least toxic of these compounds.  Alcohols and diols




are scattered throughout the list.  Although the fourth through




sixth compounds in order of decreasing toxicity are alcohols,




it is difficult to call special attention to this group in terms




of toxicity.  This is likewise the case with the chlorinated com-




pounds which are widely scattered throughout the list.  The pre-




sence of both aliphatic  and aromatic amines at the beginning and




throughout the middle of the listing does not specifically call




attention to amines as potentially toxic functions in relation to




chronic threshold dose.  To be able to determine toxicity informa-




tion from such a ranking of threshold doses it would be necessary




for many more compounds to be investigated and placed within such




a ranking.







If, as noted elsewhere, threshold dose from chronic toxicity studies




is an important means for arriving at quality criteria for chemicals




in fresh water, the apparent incompleteness of this table indicates




that efforts have not been particularly directed towards obtaining




this information.
                                48

-------
TABLE I  -  CONCENTRATION OF ORGANIC POLLUTANTS LOOKED FOR AND FOUND IN
                             FRESH WATER
     This  table lists  the concentrations of organic pollutants that
     have  been found in water and tabulated, where appropriate, ac-
     cording to their chemical composition described under Section
     3 and 4.   The  source and location of the chemicals are also
     tabulated where this information was available.  For a number
     of chemicals  several concentrations found at the same location
     at different  times or at different locations are shown, if
     available. Concentrations of pesticides in fresh water form
     the largest contribution in the US literature while the largest
     input from industrial and domestic sources were obtained from
     the  foreign  literature.

-------
       TABLE  I -  CONCENTRATION OF ORGANIC POLLUTANTS LOOKED FOR AND FOUND IN FRESH WATER
      Ref  Agent
Source
                                                             Location
                                                                                              Concentration
VO
           UNSUBSTITUTED
      291  METHANE
           CH,
           HALOGENATED
       69   ALDRIN
       439
                                                   ALKANES AND ALKENES
                                                             well water, 111.
dissolved gases
                                   product of anaerobic de-
                                   composition of organic
                                   matter in marshes, mines
                                   and sludge, digestion
                                   tanks; waste from
                                   natural gas & petroleum
                                   plants
pesticide  2-6 Ib./acre   Snake R. Pullman, Wash.
                          Hudson R. below Poughkeepsie
                          W.Y.
                          Maumee R. Toledo, Ohio
                          Mississippi R. Dubuque, Iowa
                          Detroit R. Detroit, Mich.
                          Missouri R. Kansas City, Kans.
                          Colorado R. near Boulder City
                          Nev.
                          Colorado R.,Page, Arizona
                          Rio Grande,Brownsville, Tex.
0.8 ml/1
87 ml/1
0.001 mg/1
presumptive Sept. 1964
                                                                                              0.085 ug/1
                                                                                              presumptive

-------
     TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
In
O
Ref Agent

439 ALDRIN (cont.)

174
42



139
102,
447
37







Source Location
ALKANES AND ALKENES
Snake R. Ice Harbor Dam, Wash.
Bear R. above Preston, Idaho
Snake R. , Wash.
agricultural Missouri R. at Nebraska
Arkansas R. at van Buren, Ark.
Snake R. at King Hill, Idaho
Columbia R. at Dalles, Ore.
Rio Grande, El Paso, Tex.
Snake R. Pullman, Wash
Red R., Alexandria, La.
Snake R. Wawawai, Wash.
Chattahoochee R. Lanett, Ala.
Savannah R. , N. Augusta, S.C.
Merrimack R., Lowell Mass.
Yakima R., Richland, Wash.
Yellowstone R. , Sidney, Mont.
19 stations in various river
Concentration

presumptive
it
0.001 mg/1
0.005 ug/1*
0.005 ug/tf
0.005 ug/3*
0.005 ug/I*
presumptive
0.001 mg/1
0.006 ug/1
0.003 ug/1
0.002 ug/1
<0.001 ug/1
<0.001 ug/1
<0.001 ug/1
<0.001 ug/1
presumptive

Sept. 1964
ii
it
May 1966
June 1966
ti
April 1966
1966
1967
1964
1959
1962
1958-65
1961
1958
1964

     259
      *  samples  taken monthly for one year
basins
Hudson R.
other surface waters
                                                                                             0.26 ug/1      1964
                                                                                             0.11 ug/1,  minimum value
                                                                                                        1964-66

-------
 TABLE  I  (CONT.)  - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
 Ref  Agent
Source
                                                       Location
                                                           Concentration
                                            ALKANES AND ALKENES
 357  ALDRIN (cont.)
 240
agricultural
 24
289  BENZENE HEXACHLORIDE
         H
formulating plants at
Greenville, Clarksdale,
Indianola
primary manufacturer of
endrin and heptachlor,
Memphis, Tenn.
pesticide
                          400 samples (drinking water)
                                                      Missouri R.  at  Nebraska City
                                                      Brazos  R.  at Richmond, Tex.

                                                      Rio Grande below Anzaldvas
                                                      Dam, Tex.
                                                      Colorado R., Yuma, Ariz.
                                                      Sacramento R.,  Verona, Calif.
                                                      Yakima  R.  Kiona, Wash.
                                                      Snake R.,  King  Hill,  Idaho
                                                      Columbia R., Dalles,  Ore.
                                                      Mississippi  R.  tributaries
                                                       Memphis Wolf R. Cypress Creek
                                                       complex
                                                       Tombigbee R. Ala.
over 50 samples had
detectable concentrations
none over MFC
0.02 ug/1*  May 1968
0.01 ug/1*  Feb. 1967
0.04 ug/1*  March 1967
0.02 ug/1*  June 1967

0.02 ug/1*  Feb. 1967
0.01 ug/1*  Feb. 1967
0.01 ug/1*  Oct. 1966
0.01 ug/1*  Feb. 1967
0.01 ug/1*  Feb. 1967
            1966

            1966-67
                                                           found  in fish
         Cl H
* samples taken monthly from each river for 2 years

-------
      TABLE I  (CONT.)  - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref  Agent
Source
Location
Concentration
                                                  ALKANES AND ALKENES
      439  BENZENE HEXACHLORIDE
           (cont.)
      139
Ul
ro
                          Martins Creek,  Pa.
                          Mississippi R.  at West
                          Memphis, Ark.
                          Connecticut R. at Enfield
                          Dam,  Conn.
                          Hudson R. at Narrows  N.Y.
                                 presumptive
                  1964
                                 0.004 ug/1 Sept. 1966

                                 0.034 ug/1       "
                          Apalachiocola R.,  Chattahoochee,  presumptive
                          Fla.
                          Chattahoochee R.,  Lanett,  Ala.    0.008 ug/1
                          Allegheny R., Pittsburgh,  Pa.     0.013 ug/1
                          Ohio  R.,  Evansville,  Ind.         0.002 ug/1
                          Ohio  R.,  Cincinnati,  Ohio         0.056 ug/1
                          Ohio  R.,  Addison,  Ohio           0.026 ug/1
                          Mississippi R.,  St.Paul, Minn.    0.012 ug/1
                          St. Joseph R., Benton Harbor,     0.003 ug/1
                          Mich.
                          South Platte  R., Julesburg,  Colo. 0.022  ug/1
                          Arkansas  R.,  Ponca City, Okla.    0.008 ug/1
                          Mississippi R.,  Vicksburg, Miss.  0.011 ug/1
                          Rio Grande, El Paso,  Tex.         0.023 ug/1
                          Trinity R., Livingston, Tex.     0.013 ug/1
                          Colorado  R.,  Loma, Colo.          0.006 ug/1
                          San Joaquin R.,  Vernalis,  Calif.  0.008 ug/1

-------
      TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref  Agent
Source
Location
Concentration
tn
                                                    ALKANES AND ALKENES
      439  BENZENE HEXACHLORIDE
           (cont.)
      448

      134  CHLORDANE
               C.1   CJ
           C]
      139
water supply
cotton runoff areas
pesticide applied at
<1 Ib./acre - not
used on edible crops
                          Delaware R., Martins Creek, Pa.
                          Mississippi R*, W. Memphis, Ark.
                          Red R., Grand Forks, N.D.
                          Ohio R. Cairo , 111.
                          Verdigris R., Nowata, Okla.
                          Connecticut R.,Enfield Conn.
                          Monongahela R., Pittsburgh Pa.
                          Apalachicola R., Chattahoochee,
                          Fla.
                          Sacramento R., Green's Landing
                          Calif.
                          Red R. Grand Forks, N.D.
                          St. Lawrence R., Massena, N.Y.
                          Missouri R., Kansas City
                          Savannah R., N. Augusta, S.C.
                                 presumptive     1964
                                       it           ii
                                 0.004 ug/1      19655
                                 0.002 ug/1
                                 presumptive       "
                                 0.022 ug/1    1958-64
                                              CAM top ten
                                 0.011 ug/1        "
                                 0.004 ug/1
                                 0.003 ug/1
                                 0.003 ug/1
                                 <0.001 ug/1
                                 up to 0.75 ug/1
rain water 0.15 in. Cincinnati - 0.5 mg/1
roof of Taft Center
                          Delaware Bay
                          Roanoke R., John H.  Kerr
                          Reservoir and Dam
                                 presumptive  Sept 1966
                                 0.019 ug/1     "

-------
      TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref  Agent
Source
Location
                                                                                              Concentration
      139  CHLORDANE  (cont.)
       24
Cn
       440  DIELDRIN
       439
                                                   ALKANES AND ALKENES
primary manufacturer of
endrin & heptachlor
Memphis, Tenn,
pesticide formulating
plants
pesticide
Chattahoochee R., Lanett, Ala.
Tennessee R., Bridgeport, Ala.
Missouri R., St. Louis, Mo.
Sacramento R., Green's Landing,
Calif.
Snake R. American Falls, Idaho   presumptive
Memphis Wolf. R., Cypress Creek
complex

Horseshoe Bayou, Fish Lake,
Greenville,  Jone's Bayou at
Cleveland & Sunflower at«
Clarksdale & Indianola
                                                          0.075  ug/1  Sept.  1966
                                                           presumptive    "
                                                                11         it
                                                           0.006 ug/1     "
                                                                                                              1966
                                                                                                              1966
rain-water 0.15 in. Cincinnati-
roof of Taft Center
Connecticut R. below Northfield
Mass.
Connecticut R.,Wilder Vt.
Hudson R. below Poughkeepsie
N.Y.
Merrimack R. above Lowell, Mass.
St. Lawrence R., Massena, N.Y.
Delaware R., Trenton, N.J.
Potomac R., Great Falls, Md.
0.003 mg/1

>0.022 ug/1  Sept. 1964

0.003 ug/1
0.008 ug/1      "

>0.071 ug/1     "
0.003 ug/1      "
0.009 ug/1
>0.040 ug/1     "

-------
      TABLE I (CONT.)  - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref  Agent
Source
Location
Concentration
                                                  ALKANES AND ALKENES
      439  DIELDRIN (cont.)
In
Oi
                          Schuylkill R.,  Philadelphia, Pa.
                          Shenandoah R.,  Berryville, Va.
                          Susquehanna R.,Sayre,  Pa.
                          Apalachicola R.,  Chattahoochee,
                          Fla.
                          Escambia R.,  Century,  Fla.
                          Roanoke  R.,  John  H. Kerr
                          Reservoir and Dam, Va.
                          Savannah R.,  Port Wentworth, Ga.
                          Savannah R.,  N. Augusta, S.C.
                          Clinch R.  above Kingston, Tenn.
                          Tennessee R., Bridgeport, Ala.
                          Allegheny R., Pittsburgh, Pa.
                          Ohio R.,  at  Evansville, Ind.
                          Ohio R.,  Cincinnati, Ohio
                          Wabash R., New Harmony, Ind.
                          Illinois R.,  Peoria, 111.
                          Mississippi R., Cape Girardeau,
                          Mo.
                                    East St. Louis, 111.
                                    Burlington, Iowa
                                    Lock and Dam 3 below
                                    St. Paul, Minn.
                          Rainy R.,  Baudette, Minn.
                                 >0.032 ug/1  Sept.  1964
                                 0.005 ug/1      "
                                 0.003 ug/1      "
                                 0.016 ug/1

                                 presumptive      " '
                                 0.020 ug/1
                                 >0.118 ug/1
                                 0.014 ug/1
                                 0.006 ug/1
                                 presumptive
                                 0.015 ug/1
                                 0.013 ug/1
                                 0.004 ug/1
                                 0.003 ug/1
                                 0.008 ug/1
                                 presumptive
                                 0.004 ug/1
                                 0.008 ug/1

                                 0.008 ug/1

-------
      TABLE I (CONT.)  - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref  Agent
Source
Location
Concentration
                                                   ALKANES  AND ALKENES
      439  DIELDRIN (cont.)
                          Red.  R.,  Grand Forks,  N.D.
                          Lake  Michigan, Milwaukee, Wis.
                          Lake  Superior, Duluth, Minn.
                          Big Horn  R.  Hardin, Mont.
                          Kansas R., DeSoto, Kans.
                          Missouri  R., St.Louis, Mo.
                                   Omaha,  Nebr.
                                   Yankton, S.D.
                                   Bismark, N.D.
                                 0.004 ug/1  Sept
                                 0.007 ug/1
                                 presumptive    "
                                 0.012 ug/1
                                 0.004 ug/1     "
                                 0.012 ug/1
                                 presumptive
                                 0.009 ug/1
                                 0.005 ug/1
                                 0.006 ug/1
in
                          N.  Platte R.  above Henry Nebr.
                          Platte R. above Plattsmouth,  Nebr.  0.023 ug/1
                          S.  Platte R., Julesburg, Colo.    0.016  ug/1
                          Yellowstone R. near Sidney, Mont.  0.008 ug/1
                          Arkansas R.,  Little Rock, Ark.    0.004  ug/1
                                    near Ponca City, Okla.  0.008  ug/1
                                                                                             presumptive
                                                                                                   it
                                                                                             0.016 ug/1
                                                                                             0.017 ug/1
                                                                                             presumptive
                                    Coolidge,  Kans.
                          Mississippi R., New Orleans,  La
                                    New Roads, La.
                                    Vicksburg, Miss.
                                    Delta, Va.
                                    West Memphis, Tenn.         "
                                                           0.007 ug/1
                                                           0.003 ug/1
                          Atchafalaya R., Morgan City,  La.  0.009 ug/1
                          Verdigris R., Nowata, Okla.       0.005 ug/1
                                                             Red R.
        (south), Alexandria La.
          Denison Tex.
                                                it
                                                it
                  1964

-------
      TABLE I (CONT.)  - CONCENTRATION  OF  ORGANIC  POLLUTANTS  IN WATER
      Ref  Agent
Source
Location
Concentration
                                                   ALKANES AND ALKENES
      439  DIELDRIN (cont.)
in
      42
agricultural
Colorado R., Yuma, Ariz.
          Parker Dam, Ariz.-
          Calif.
          Bolder City, Nev.
          Page, Ariz.
          Loma, Colo.

Rio Grande, Brownsville, Tex
          Laredo, Tex.
          El Paso, Tex.
          below Alamosa, Colo.

Columbia R., Clatskanie, Ore.
          Pasco, Wash.

Pend Oreille R., Albeni Falls
Dam, Idaho

Snake R., Ice Harbor Dam, Wash.
          Wawawai, Wash.

Spokane R., Post Falls Dam,
Idaho

Willamette R., Portland, Ore.
Klamath R. near Keno, Ore.

Sacramento R., Green's Landing,
Calif.
Bear R. above Preston, Idaho

Missouri R. at Nebraska City,
Nebr.
                                                           presumptive  Sept. 1964
                                                                it
                                                                                             0.002 ug/1
                                                                                             0.006 ug/1
                                                                                             0.008 ug/1

                                                                                             0.005 ug/1
                                                                                             0.009 ug/1
                                                                                             0.032 ug/1
                                                                                             0.007 ug/1
                                                                                             0.015 ug/1
                                                                                             0.002 ug/1

                                                                                             presumptive
                                                                                                             II
                                                                                                             II
                                                           0.003 ug/1
                                                           presumptive

                                                           0.007 ug/1


                                                           0.011 ug/1
                                                           presumptive

                                                           0.004 ug/1
0.006 ug/1      "

0.010 ug/1*' Oct. 1965
      *  sample taken monthly from each river for one year

-------
      TABLE  I  (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS  IN WATER
     Ref  Agent
Source
Location
Concentration
                                                  ALKANES AND ALKENES
      42   DIELDRIN  (cont.)
                          Missouri R. at Nebraska
                          City, Nebr.
                                                            Arkansas R. below John Martin
                                                            Reservoir, Colo.

                                                            Arkansas R. at van Buren, Ark.
Cn
CO
                                                             Brazos R. at Richmond Tex.
                                                            Colorado R. at Wharton, Tex.
                                                            Rio Grande below Anzalduas
                                                            Dam, Tex.
                                                            Colorado R. ( Yuma Main Canal)
                                                            at Yuma, Colo.

                                                            Sacramento R. at Verona, Calif,
                                                            Yakima R. at Kiona, Wash.
                                 0.005 ug/1*  Feb. 1966
                                 0.015 ug/1*  March 1966
                                 0.005 ug/1*  April 1966
                                 0.015 ug/1*  May 1966
                                                           0.005 ug/1*
                                                           0.005 ug/1*
                                              Oct. 1966
                                              April 1966
                                                           0.005 ug/1*  Dec. 1965
                                                           0.005 ug/1*  Feb. 1965
                                                           0.005 ug/1*  Apr. 1966
                                                           0.010 ujj/1*  July 1966
                                                           0.010 ug/1*  Aug. 1966

                                                           0.010 ug/1*  Feb. 1966
                                                           0.015 ug/1*  May 1966
                                                           0.010 ug/1*  June 1966

                                                           0.005 ug/1* Oct. 1965
                                                           0.010 ug/1*  Jan.-Feb.
                                                           1966

                                                           0.010 ug/1*  Oct. 1965
                                                           0.015 ug/1*  Nov. 1965
                                                           0.015 ug/1*  Dec. 1965
                                                           0.010 ug/1*  Jan. 1966
                                                           0.010 ug/1*  July 1965

                                                           0.005 ug/1*  March 1966


                                                           0.010 ug/1*'  March 1966
                                                           0.005 ug/1*  May 1966

                                                           0.005 ug/1*  March 1966
     * sample taken monthly from each river for one year

-------
     TABLE I  (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref  Agent
Source
Location
                                                                                             Concentration
     42   DIELDRIN (cont.)
     139
SO
                          ALKANES  AND  ALKENES
                          Snake R.  at  King  Hill,  Idaho
                          Columbia R.  at Dalles,  Ore.
                          Connecticut R. Enfield Dam, Conn.
                          Connecticut R. Northfield, Mass.
                          Hudson R., Poughkeepsie, N.Y.
                          Hudson R., Narrows, New York
                          Merrimack R., Lowell, Mass.
                          Delaware R., Trenton, N.J.
                          Delaware R., Martins Creek, Pa.
                          Schuylkill R. Philadelphia, Pa.
                          Delaware Bay

                          Shenandoah R., Berryville, Va.
                          Susquehanna  R., Conowingo, Md.
                          Roanoke  R.,  John  H. Kerr
                          Reservoir and Dam, Va.
                          Neuse R., Raleigh, N.C.
                          Alapachicola R.,  Chattahoochee,
                          Fla.
                          Savannah R., Port Wentworth, Ga.
                                   North Augusta, Ga.
                                 0.005 ug/1*  April 1966
                                 0.010 ug/1*  Dec.  1965
                                 0.016 ug/1  Sept.  1966
                                 0.017 ug/1
                                 0.003 ug/1
                                 presumptive
                                 0.167 ug/1
                                 0.003 ug/1     "
                                 0.014 ug/1     "
                                 0.015 ug/1
                                 0.010 ug/1
                                 0.025 ug/1     "
                                 0.008 ug/1
                                 0.031 ug/1     "
                                 0.006 ug/1

                                 0.004 ug/1     "
                                 0.004 ug/1
                                                                                            0.048 ug/1
                                                                                            0.110 ug/1
     * sample taken monthly from each river for  one  year

-------
     TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS  IN  WATER
     Ref  Agent
Source
Location
Concentration
                                                  ALKANES AND ALKENES
     139  DIELDRIN (cont.)
                          Tennessee R. ,  Bridgeport,  Ala.
                                    Lenoir City,  Tenn.
                          Allegheny R.,  Pittsburgh,  Pa.
                          Kanawha  R. , Winf ield Dam,
                          West Va.
                          Ohio R. Cairo, 111.
                                    Evansville, Ind.
                                  1  Cincinnati, Ohio
                                                            Illinois R.,  Peoria,  111.

                                                            Mississippi R.,  Cape  Girardeau,   0.009  ug/1
                                                            Mo.
                                 0.004 ug/1  Sept.  1966
                                 0.005 ug/1
                                 0.004 ug/1     "
                                 0.015 ug/1     "

                                 0.004 ug/1     "
                                 0.004 ug/1     "
                                 0.003 ug/1     "
                                 0.003 ug/1     "
o\
o
                          Mississippi R. ,  E.  St.  Louis
                          111.
                                    Burlington,  Iowa
                                    Dubuque ,  Ipwa

                          St.  Joseph R. , Benton  Harbor,
                          Mich.

                          Grand  R. ,  Grand  Haven,  Mich

                          Kansas R. , De  Soto,  Kansas
                          Missouri  R., St. Louis, Mo.
                                    Kansas City,  Kans.
                                 presumptive

                                 0.007 ug/1
                                 0.002 ug/1
                                 presumptive
                                                                                             0.004  ug/1
                                                                                             presumptive
                                                                                             0.004  ug/1
                                                            North Platte R.  above Henry,
                                                            Nebr.
                                                           0.004 ug/1

                                                           0.004 ug/1

                          Red R.  (north),  Grand Forks,  N.D.  presumptive
                                                            Platte R.  above Plattsmouth,
                                                            Nebr.

-------
TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
Source
Location
                                                                                        Concentration
                                             ALKANES AND ALKENES
139   DIELDRIN (cont.)
                          Red R.,  Intern.  Boundary
                          Atchafalaya R.,  Morgan City,  La,
                          Arkansas R., Pendleton Ferry,
                          Ark.
                                       Fort Smith, Ark.
                                       Ponca City, Okla.
                          Brazos R.,  Arcola, Tex.
                          Mississippi R.,  New Orleans,  La.
                                          Vicksburg,  Miss.
                                          Delta, La.
                                          W. Memphis, Ark.
                          Red R.  (S), Alexandria, La.
                          Rio Grande, below Alamosa,  Colo.
                          Trinity  R., Livingston, Tex.
                          Verdigris R., Nowata,  Okla.
                          Bear  R., Preston, Idaho
                          Colorado R., Page, Ariz.
                                       Loma, Colo.
                          Sacramento  R., Green's Landing,
                          Calif.
                          Waikele  Stream,  Oahu,  Hawaii
                          Columbia R., Clatskanie, Ore.
                          Snake R., Payette, Idaho
                          Willamette  R., Portland, Ore.
                                 presumptive  Sept. 1966
                                                                                        0.005 ug/1
                                                                                        0.001 ug/1
                                                                                        presumptive
                                                                                        0.004 ug/1
                                                                                        0.005 ug/1
                                                                                        0.003 ug/1
                                                                                        0.005 ug/1
                                                                                        0.004 ug/1
                                                                                        0.012 ug/1
                                                                                        presumptive
                                                                                        0.012 ug/1
                                                                                        presumptive
                                                                                        0.010 ug/1
                                                                                        0.003 ug/1
                                                                                        0.002 ug/1
                                                                                        0.003 ug/1
                                                                                        0.004 ug/1
                                                                                        presumptive
                                                                                        0.004 ug/1
                                                                                        0.004 ug/1
                                                 it
                                                 it

-------
     TABLE I. (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
Source
Location
Concentration
                                                  ALKANES AND ALKENES
     139   DIELDRIN (cont.)
                                                                         1965
                                                                          it
N>
Tombigbee R., Columbus, Miss.    0.100 ug/1
Merrimack R., Lowell, Mass.      0.068 ug/1
Savannah R., N. Augusta, S.C.    0.051 ug/1     "
Kanawha R., Winfield Dam, W. Va. 0.045 ug/1     "
Rio Grande, Alamosa, Colo.       0.029 ug/1     "
Tennessee R., Lenoir City, Tenn. 0.028 ug/1     "
Ohio R., Cairo, 111.             0.028 ug/1     "
Mississippi R., Dubuque, Iowa    0.024 ug/1     "
Missouri R., Kansas City, Kans.  0.023 ug/1     "
Savannah R., Pt. Wentworth, Ga.  0.022 ug/1     "
Mississippi R., W. Memphis, Ark. 0.122 ug/1  1958-64CAM
Savannah R., Augusta, S.C.       0.056 ug/1     "
Ohio R., Cincinnati, Ohio        0.055 ug/1
Schuylkill R., Phila., Pa.       0.035 ug/1     "
Mississippi R., New Orlean, La.  0.034 ug/1     "
Delaware R., Phila., Pa.         0.033 ug/1     "
Apalachicola R., Chattahoochie,
Fla.                             0.024 ug/1     "
Mississippi R., Vicksburg, Miss. 0.023 ug/1     "
                Delta, La.       0.022 ug/1     "
Savannah R., Pt. Wentworth, Ga.  0.016 ug/1     "
Merrimack R., Lowell, Mass.      0.016 ug/1     "

-------
      TABLE  I  (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Re£   Agent
Source
Location
Concentration
                                                  ALKANES AND ALKENES
      37   DIELDRIN (cont.)
ON
u>
                          Connecticut R.,  Northfield,
                          Mass.
                          Delaware R., Trenton,  N.J.
                          Potomac R., Washington,  D.C.
                                      Great Falls, Md.
                          Schuylkill  R., Phila., Pa.
                          Susquehanna R.,  Conowingo,  Md.
                                          Sayre, Pa.
                          Apalachicola R.,  Chattahoochee
                          Fla.
                          Chattahoochee R., Lanett, Ala.
                          Clinch R.,  Kingston, Tenn,
                          Monongahela  R.,  Pittsbuigh, Pa.
                          Ohio R.,  Evansville, Ind.
                                   Cincinnati, Ohio
                                   Addison, Ohio
                          Maumee R.,  Toledo,  Ohio
                          Mississippi R., E.  St. Louis,
                          111.
                                         Burlington, Iowa
                           Lock &  Dam 3, St. Paul, Minn.
                          Red  R.  (N),  Grand Forks,  N.D.
                          Detroit R.,  Detroit, Mich.
                          Lake Michigan, Milwaukee, Wis.
                                 presumptive  Sept. 1965
                                 0.018 ug/1      "
                                 0.003 ug/1      "
                                 0.016 ug/1
                                 0.014 ug/1      "
                                 0.002 ug/1      "
                                 presumptive

                                 0.016 ug/1
                                 0.005 ug/1      "
                                 0.007 ug/1
                                 0.005 ug/1      "
                                 0.002 ug/1
                                 0.006 ug/1
                                 0.007 ug/1
                                 0.024 ug/1

                                 0.005 ug/1
                                 0.009 ug/1
                                 presumptive
                                 0.007 ug/1
                                 0.018 ug/1
                                 0.003 ug/1
                                                                                                             it
                                                                                                             it

-------
TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS  IN WATER
Ref   Agent
Source
Location
                                 Concentration
                                             ALKANES AND ALKENES
 37   DIELDRIN (cont.)
448, 385
24
Primary manufacturer
of endrin & heptachlor
Memphis, Tenn,
                          Kansas R.,  DeSoto, Kans.
                                 0.003 ug/1  Sept.  1965
                                 0.004 ug/1
Missouri R., St. Louis, Mo.
             Kansas City, Kans.  0.023 ug/1     "
Platte R., Plattsmouth, Nebr.    0.010 ug/1     "
Atchafalaya R., Morgan City,  La.0.013 ug/1     "
Mississippi R., New Orleans, La. 0.005 ug/1     "
                Vicksburg, Miss. 0.004 ug/1     "
                Delta, La.       0.004 ug/1     "
                W. Memphis, Ark. 0.018 ug/1     "
San Juan R., Shiprock, N. Mex.   presumptive    "
Rio Grande, El Paso, Tex.        0.003 ug/1     "
Columbia R., Clatskanie, Ore.    0.003 ug/1     "
Willamette R., Portland, Ore.    0.005 ug/1     "
Sacramento R., Greens Landing,
Calif.                           0.011 ug/1
San Joaquin R., Vernalis, Calif. 0.005 ug/1     "
Waikele Stream, Hawaii           0.018 ug/1     "
100 locations in U.S.            0.0000-0.118 ug/1 1965
Memphis Wolf R., Cypress Creek                  1966-67
Complex

-------
    TABLE  I  (CONT.) -  CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
    Ref   Agent
Source.
Location
                                                                                           Concentrat ion
                                                ALKANES AND ALKENES
     24   DIELDRIN  (cont.)
Pesticide formulating
plants
     38

    259
application to foliage
soil and water courses
Ui
    357
    240
agricultural
Horseshoe Bayou and Fish Lake at
Greenville, Jones Bayou at Cleveland
and Sunflower R. at Clarksdale and
Indianola
                                                                                                         1966
London, England (rainwater)
Britain

USA (river basins)

Savannah R., N. Augusta, S.C.


Niagara R.
                                                          drinking water
Missouri R. at Nebraska City
Nebr.
                                                          Platte R., Brady, Nebr.
                                                          Arkansas R. below John Martin
                                                          Reservoir, Colo.
                                                          Brazos R. at Richmond, Tex.
3.3-17.3 ug/1 Aug. 66-July 67
1.5-4.7 ug/1
5.7-7.7 ug/1  1964
2.0-3.4 ug/1  1965
              1962


0.083 ug/1 max. value
             August 1964
0.006 ug/1 min. value
             Sept. 1965

found in 195 out of 455
           samples
1 exceeds MPC


0.01 ug/1*  March 1967
0.07 ug/1*  June 1967
0.04 ug/1*  May 1968

0.01 ug/1*  Jan. 1968


0.01 ug/1*  May 1968
0.01 ug/1*  June 1968
0.01 ug/1*  July 1968

0.01 ug/1*  April 1968
    *  sample  taken monthly  from each river  for two years.

-------
      TABLE I (CONT.). - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
                                   Source
                          Location
                                 Concentration
ON
ALKANES AND ALKENES
240 DIELDRIN (cont.) Colorado R., Wharton, Tex. J.
Gila R.
below Gillespie, Ariz. 0.
0.
0.
Yakima R. , Kiona, Wash. 0.
0.
0.
0.
Snake R
. , King Hill, Idaho 0.
Columbia R., Dalles, Ore. 0.
309 ENDOSULFAN pesticide spillage Rhine R
(Thiodan)
Cl
ci T'CIU-O
Cl Z
ENDRIN chlorinated organic
PI pesticide
•



01
01
02
01
01
02
04
01
oi
01




ug/1*
ug/1*
ug/1*
ug/1*
ug/1*
ug/1*
ug/1*
ug/1*
ug/1*
ug/1*




March
Nov.
April
Sept.
March
April
June
Oct.
June
Oct.




1967
1967
1968
1968
1967
1967
1967
67-July 68
1967
1966




23 />lv/" x^/T^ manufacturing plants Mississippi R. (119 points) High
224 JaCLJH--Hrj) pesticide, cane farming surface
waters in Louisiana 0.
0.
36
70
ug/1
ug/1
1961
1964

      439
                Cl
pesticides
Connecticut R. below Northfield
Mass.
                                                                                              0.25 ug/1  Sept. 1964
      * sample taken monthly from each river for two years.

-------
     TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
Source
Location
Concentration
                                                  ALKANES AND ALKENES
     439   ENDRIN (cont.)
                                                           presumptive
                                                           0.94 ug/1
                                                           0.009 ug/1
                                                           presumptive
                                                           presumptive
ON
St. Lawrence R., Massena, N.Y.
Potomac R., Great Falls, Md.
Shenandoah R., Berryville, Va.
Escambia R., Century, Fla.
Susquehanna R., Sayre, Pa.
Clinch R., above Kingston, Tenn. 0.015 ug/1
Tennessee R., Bridgeport, Ala.   0.005 ug/1
Allegheny R., Pittsburgh, Pa.    presumptive
Ohio R., Evansville, Ind.             "
Mississippi R., E. St. Louis, ill.    "
                Burlington, Iowa 0.004 ug/1
                Lock & Dam 3
below St. Paul
Rainy R., Baudette, Minn.
Red R. (N), Grand Forks, N.D.
Lake Michigan, Milwaukee, Wis.
Big Horn R.,  Hardin, Mont.
Kansas R.,  DeSoto, Kan.
             Sept. 1964
                                                                                             0.006  ug/1
                                                                                             0.011  ug/1
                                                                                             0.023  ug/1
                                                                                             0.006  ug/1
                                                                                             0.026  ug/1
                                                                                             0.005  ug/1
                                                           Missouri  R.,  St. Louis, Mo.       0.009 ug/1
                                                                         Bismark, N. D.       0.009 ug/1
                                                           S. Platte R., Julesburg, Colo.,
                                                           S. Channel                        0.014 ug/1
                                                           Yellowstone R., near Sidney,
                                                           Mont.                             0.021 ug/1

-------
     TABLE. I, (CQNT.X - CONCENTRATION*OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
Source
Location
Concentration
                                                  ALKANES AND ALKENES
     439   ENDRIN  (cont.)
                          Arkansas R., Little Rock, Ark.
                                       near Fonca City,
                          Ark.
                                 0.008 ug/1   Sept. 1964

                                 0.014 ug/1
                                                            Mississippi R., New Orleans, La. presumptive
                                                                            New Roads, La.   0.023 ug/1
                                                                            Vicksburg, Miss. 0.025 ug/1
                                                                            Delta, Miss.     presumptive
                                                                            W. Memphis, Ark.      "
ON
00
                          Red R. (S), Alexandria, La.
                                      Denison, Tex.

                          Atchafalaya R.,Morgan City, La.

                          Verdrigis R., Nowata, Okla.

                          Colorado R., Yuma, Ariz.

                          Colorado R., above Parker Dam
                         • Ariz.
                                       Page, Ariz.

                          Rio Grande, Laredo, Tex.
                                      El Paso, Tex.

                          Columbia R., Olatskanie, Ore.
                                       Pasco, Wash.

                          Pend Oreille R., Albeni Fall Dam
                          Idaho                                 "

                          Willamette R., Portland, Ore.    0.017 ug/1
                                 0.013 ug/1
                                 0.007 ug/1

                                 0.018 ug/1

                                 0.013 ug/1

                                 presumptive

                                      ti
                                 0.012 ug/1

                                 0.003 ug/1
                                 0.067 ug/1

                                 0.019 ug/1
                                 presumptive
                                                            Sacramento R., Greens Landing,
                                                            Calif.

                                                            Bear R., above Preston, Idaho
                                                           presumptive
                                                           0.009 ug/1
                n

                n

                n
                                                                                                             n

                                                                                                             n
                                                 n

                                                 n

-------
TABLE I CCONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
Source
Location
Concentration
                                             ALKANES AND ALKENES
 37   ENDRIN  (cont.)
                          Delaware R.,  Trenton, N.J.       0.018 ug/1
                          Tombigbee R., Columbus, Miss.     0.015 ug/1
                          Clinch R., above Kingston, Tenn.  0.015 ug/1
                          Tennessee R., Lenoir City, Tenn.  0.009 ug/1
                          Kanawha R., Winfield Dam,  W. Va.  presumptive
                          Monongahela R.,  Pittsburgh, Pa.   0.014 ug/1
                          Red  R.  (N), Grand Forks, N.Y.     0.009 ug/1
                                              Sept. 1965
                                                       Missouri R.,  St.  Louis,  Mo.
                                                       Platte R.,  above  Plattmouth,
                                                       Nebr.
                                                       S.  Platte R.,  Julesburg,  Colo.
                                                       Atchafalaya R.,Morgan City, La.
                                                       Mississippi R., Delta, La.
                                                           presumptive   Sept. 1965
                                                           0.019 ug/1
                                                           0.008 ug/1
                                                                       W.  Memphis, Ark.  0.116 ug/1
                                                       Colorado  R.,  Page,  Ariz.          presumptive
                                                       Rio  Grande, below Alamosa, Colo.  0.014 ug/1
                                                       San  Joaquin R.,  near Vernalis,
                                                       Calif.                            0.005 ug/1
                                                       Mississippi R.,  W.  Memphis, Ark.  0.214 ug/1
                                                                       New Orleans, La.  0.160 ug/1
                                                                       Vicksburg, Miss.  0.072 ug/1
                                                                       Delta, La.        0.044 ug/1
                                                       Connecticut R.,  Enfield Dam,
                                                       Conn.                             0.023 ug/1
                                                       Atchafalaya R.,  Morgan City, La.  0.015 ug/1
                                                                        1958-1965

-------
     TABLE  I  (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref   Agent
Source
Location
Concentration
                                                  ALKANES AND ALKENES
      139    ENDRIN (cont.)
pesticide
VJ
o
Connecticut R., Northfield, Mass.0.014 ug/1    Sept. 1966
Hudson R., Narrows, N.Y.         0.069 ug/1      "
Roanoke R., John Kerr Reservoir
and Dam, Va.                     0.011 ug/1      "
Neuse R., Raleigh, N.C.          0.008 ug/1      "
Savannah R., Port Wentworth, Ga. 0.031 ug/1      "
             N. Augusta, Ga.     0.022 ug/1      "
Tennessee R., Bridgeport, Ala.   0.004 ug/1      "
              Lenoir City, Tenn. 0.006 ug/1      "
Allegheny R., Pittsburgh,Pa.     0.003 ug/1      "
Lake Superior, Duluth, Minn.     0.022 ug/1      "
Mississippi R., Dubuque, Iowa    0.003 ug/1      "
St. Joseph R., Benton Harbor,
Mich.                            0.029 ug/1      "
Missouri R., Kansas City, Kan.   0.005 ug/1
N. Platte R., above Henry, Neb.  0.009 ug/1     "
S. Platte R., Julesburg, Colo.   0.063 ug/1     "
AtchafalayaR.,Morgan City, La.   0.006 ug/1     "
Arkansas  .., Fort Smith, Ark.-   0.004 ug/1     "
Mississippi R., New Orleans, La. 0.011 ug/1     "
                Vicksburg, Miss. 0.012 ug/1     "
                Delta, La.       0.014 ug/1     "
Bear R., Preston, Idaho          0.019 ug/1     "

-------
TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
Source
Location
                                                                                        Concentration
                                             ALKANES AND ALKENES
139   ENDRIN (cont.)
42
agricultural
269
commercial orchard
447
448
 Sacramento  R.,  Greens Landing,
 Calif.
 Clearwater  R.,  Lewiston,  Idaho
 Columbia  R.,  Bonneville,  Ore.
 Willamette  R.,  Portland,  Ore.
 Mississippi R.

Missouri R., Nebraska City, Nebr
Colorado R., Wharton, Tex.
Rio Grande below Anzalduas Dam,
Tex.
Colorado R. (Yuma Main Canal)
Yuma, Ariz.
Snake-R., King Hill, Idaho
Knights Creek (Dunn County) Wis,
Mississippi R., Cape Girardeau,
Mo.
Allegheny R., Pittsburgh, Pa.
Rio Grande, Brownsville, Tex.
Mississippi R., New Road, La.
Mississippi and Sacramento R.
Analysis of water in 100 loca-
tions in the U.S.
 0.005 ug/1
 0.015 ug/1     "
 0.009 ug/1     "
 presumptive
 up to .214 ug/1    1963
 0.015-0.116 ug/1   1964
.0.035 ug/1*   May 1966
 0.005 ug/1*   Oct.  1965

 0.010 ug/1*   Feb.  1966
 0.040 ug/1*   May 1966
 0.025 ug/1*   June  1966

 0.015 ug/1*   June  1966
 0.025 ug/1*   Feb.  1966
               June  1966

 0.013 ug/1
 0.012 ug/1
 0.011 ug/1        "
 0.010 ug/1        "
 0.500 ug/1

 0.0-0.94 ug/1   1966

-------
      TABLE I CCONT.)  - CONCENTRATION OF ORGANIC POLLUTANTS  IN WATER
      Ref   Agent
Source
Location
                                 Concentration
Is)
                                                   ALKANES  AND ALKENES
       24   ENDRIN (cont.)
       23   HEPTACHLOR
               Cl
      439
           cr
               Cl Cl  H
primary manufacturer of
endrin and heptachlor,
Memphis, Tenn.
pesticides formulating
plants
pesticide
                                                 1966-67
Memphis Wolf R., Cypress Creek
Complex

Horseshoe Bayou and Fish Lake
at Greenville, Jones Bayou at
Cleveland and Sunflower R. at
Clarksdale and Indianola
119 point along Mississippi R.   High concentration near
                                 plants which manufacture
                                 endrin and heptachlor
Delaware R., Martin's Creek, Pa. presumptive   Sept. 1964
Potomac R., Washington, D.C.          "            "
Escambia R., Century, Fla.            "            "
Roanoke R., John H. Kerr Reservoir
& Dam, Va.                            "            "
Savannah R., N. Augusta, S.C.         "            "
Clinch R., Kingston, Tenn.            "            "
Maumee R., Toledo, Ohio               "            "
Red R. (N), Grand Forks, N.D.         "            "
St. Claire R., Port Huron, Mich.      "            "
Missouri R., Kansas City, Kan.        "            "
S. Platte R., Julesburg, Colo.
(N. Channel)                          "            "
Arkansas R., Ponca City, Okla.        "            "

-------
      TABLE I. (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
CO
Ref Agent Source 	 Location
ALKANES AND ALKENES
439 HEPTACHLOR (cont.) Mississippi R. , New Orleans, La.
W. Memphis, Ark.
Colorado R., Boulder City, Nev.
Spokane R. , Post Falls Dam,
Idaho
310, 42 agricultural Missouri R. at Nebraska City,
Nebr.
Arkansas R. below John Martin
Reservoir
Arkansas R. , Reservoir, Colo.
at Van Buren, Ark.
Brazos R. at Richmond, Tex.
Colorado R. , at Wharton Tex.
Rio Grande below Anzalduas Dam,
Tex.
Yakima R. at Kiona, Wash.
Snake R. at King Hill, Idaho
139 Missouri R. , Kansas City, Kans.
37 Merrimack R. , Lowell, Mass.
St. Lawrence R. , Massena, N.Y.
Delaware R. , Martins Creek, Pa.
Concentration
presumptive
11
ii
ii
0.005 ug/1*
0.005 ug/1*
0.010 ug/1*
0.005 ug/1*
0.005 ug/1*
0.015 ug/1*
0.005 ug/1*
0.010 ug/1*
0.015 ug/1*
0.005 ug/1*
0.015 ug/1*
0.005 ug/1*
0.005 ug/1*
0.004 ug/1
presumptive
0.031 ug/1
0.025 ug/1

Sept. 1964
ii
ti
ii
Aug. 1966
Oct. 1965
May 1966
July 1966
March 1966
June 1966
Oct. 1965
Oct. 1965
Dec. 1965
Jan. 1966
May 1966
July 1966
Feb. 1966
Sept. 1966
Sept. 1965
ii
ii
       *  samples  taken from each river monthly for one year

-------
TABLE I (C.ONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
Source
Location
                                                                                        Concentration
                                             ALKANES AND ALKENES
 37   HEPTACHLOR (cont.)
                          Potomac R.,  Great Falls, Md.
                          Savannah R., Pt. Wentworth, Ga.
                          Tennessee R., Lenoir City, Tenn.
                          Kanawha R.,  Winfield Dam, W. Va.
                          Ohio R., Cincinnati, Ohio
                                   Addison, Ohio
                          Wabash R., New Harmony, Ind.
                          Illinois R., Peoria, 111.
                          Mississippi R., Burlington, Iowa
                                          Dubuque, Iowa
                          Red R. (N),  Grand Forks, N.D.
                          Detroit R.,  Detroit, Mich.
                          Missouri R., St. Louis, Mo.
                                       Kansas City, Kans.
                          Atchafalaya R., Morgan City, La.
                          Colorado R., Page, Ariz.
                          San Juan R., Shiprock, N. Mex.
                          Rio Grande,  Brownsville, Tex.
                                      Alamosa, Colo.
                          Sabine R., Ruliff, Tex.
                          Sacramento R., Greens Landing,
                          Calif.
                          Atachfalaya R., Morgan City, La.
                                 presumptive  Sept. 1965
                                      ti          'I
                                 0.020 ug/1      "
                                 presumptive     "
                                 0.024 ug/1      "
                                 presumptive     "
                                 0.009 ug/1      "
                                 presumptive     "

                                 0.048 ug/1      "
                                 0.115 ug/1      "
                                 0.015 ug/1
                                 0.020 ug/1      "
                                 0.008 ug/1
                                 0.010 ug/1
                                 presumptive
                                 0.012 ug/1      "
                                 0.035 ug/1      "
                                 presumptive
                                                                                        0.020 ug/1
                                                                                        0.002 ug/1
                                               1958-65*
   * Highest level during time studied

-------
       TABLE I (CONT.)  - CONCENTRATION OF ORGANIC  POLLUTANTS  IN WATER
       Ref   Agent
Source
Location
                                                           Concentration
                                                   ALKANES AND ALKENES
        37    HEPTACHLOR (cont.)
       240
Ui
Mississippi R., W. Memphis, Ark.
Potomac R., Great Falls, Md.
Detroit R., Detroit, Mich.

Missouri R., at Nebraska City
                                                             Arkansas R. below John Martin
                                                             Reservoir, Colo.

                                                                         at van Buren, Ark.
                                                             Brazos R. at Richmond, Tex.

                                                             Colorado R., Wharton, Tex.
                                                             Rio Grande below Anzalduas Dam,
                                                             Tex.  ,
                                                             Colorado R.  (Yuma Main Canal),
                                                             Yuma, Ariz.
                                                             Sacramento R. at Verona, Calif.
                                                             Yakima R., Kiona, Wash.

                                                             Snake R., King Hill, Idaho
                                                           presumptive   1958-65
                                                                                                    11

                                                                                                    it
                                                           0.01 ug/1*  March 1967
                                                           0.01 ug/1*  April 1967
                                                           0.04 ug/1*  June 1967
                                                           0.01 ug/1*
                                                           0.02 ug/1*
                                                           0.01 ug/1*
                                                           0.01 ug/1*
                                                           0.01 ug/1*

                                                           0.02 ug/1*
                                                           0.02 ug/1*

                                                           0.01 ug/1*


                                                           0.01 ug/1*
                                                           0.01 ug/1*
                                                           0.02 ug/1*


                                                           0.01 ug/1*

                                                           0.02 ug/1*

                                                           0.01 ug/1*


                                                           0.02 ug/1*
                                                           0.01 ug/1*
                                                           0.04 ug/1*
                                             Feb. 1967
                                             June 1967
                                             March 196 /
                                             April 1967
                                             May 1967
                                             Feb. 1967
                                             June 1967
                                             Jan. 1967
                                             Feb. 1967
                                             March 1967
                                             June 1967


                                             March 1967

                                             Feb. 1967

                                             Oct. 1966-
                                             April 1967

                                             Feb. 1967
                                             March 1967
                                             April 1967
      * samples taken monthly from each river for two years.

-------
    TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
    Ref   Agent
Source
Location
                                                                                            Concentration
Oi
                                                 ALKANES AND ALKENES
    240   HEPTACHLOR (cont.)




    357

     24
440   HEPTACHLOR EPOXIDE


  23



439

  42
manufacturer of endrin
and heptachlor
pesticide formulating
plant
                                 pesticide
                                 agricultural
                          Columbia R., Dalles, Ore.
drinking water


Memphis Wolf R., Cypress Creek
Complex

Horseshoe Bayou and Fish Lake
at Greenville, Jones Bayou at
Cleveland and the Sunflower R.
at Clarksdale and Indianola

rain water 0.15 in.  Cincinnati
roof of Taft Center
119 points along Mississippi R.
                          None detected in any river tested

                          Missouri R.  at Nebraska City,
                          Nebr.
                                                                                        0.01 ug/1*  Jan. 1967
                                                                                        0.01 ug/1*  Feb. 1967
                                                                                        0.02 ug/1*  March 1967
                                                                                        0.01 ug/1*  June 1967
                                                                                        50 out of 125 samples -
                                                                                        none over MPC


                                                                                        1966-1967
                                                                                            1966
                                                                                            0.04  ug/1

                                                                                            High  cone, near plants manu-
                                                                                            facturing endrin and  hepta-
                                                                                            chlor

                                                                                                        Sept. 1964
                                                          Arkansas R. below John Martin
                                                          Reservoir, Colo.
                                 0.005 ug/1* May 1966
                                 0.005 ug/1* July 1966


                                 0.005 ug/1* Oct. 1965
                                 0.005 ug/1* Feb. 1966
                                 0.005 ug/1* July 1966
    * samples taken monthly from each river for one year.

-------
TABLE I, (CQNT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
                             Source
Location
Concentration
ALKANES AND ALKENES
42 HEPTACHLOR EPOXIDE (cont.) Arkansas R. at van Buren, Ark.
Brazos R. at Richmond, Tex.
Colorado R. at Wharton, Tex.
Rio Grande below Anzalduas Dam,
Tex.
Colorado R. (Yuma Main Canal) ,
Yuma, Ariz.
42 pesticide Sacramento R. at Verona, Calif.
Yakima R. at Kiona, Wash.
Snake R. at King Hill, Idaho
Columbia R. at Dalles, Ore.
139 Connecticut R. , Northfield, Mass
Hudson R., Narrows, N.Y.
Schuylkill R. , Philadelphia, Pa.
Shenandoah R., Berryville, Va.
Neuse R. , Raleigh, N.C.
Chattahoochie R. , Lanett, Ala.
Savannah R., Pt. Wentworth, Ga.
Tennessee R. , Bridgeport, Ala.
0.005 ug/1* March 1966
0.005 ug/1* Feb. 1966
0,005 ug/1* April 1966
0.005 ug/1* Oct. 1965
0.005 ug/1* Jan. 1966
0.005 ug/1* Oct. 1965
0.010 ug/1* March 1966
0.005 ug/1* Jan. 1966
0.005 ug/1* Jan. 1966
0.005 ug/1* March 1966
0.005 ug/1* March 1966
0.005 ug/1* July 1966
0.005 ug/1* Jan. 1966
0.005 ug/1* Jan. 1966
.0.001 ug/1 Sept. 1966
0.007 ug/1 "
presumptive "
11 it
0.008 ug/1
0.004 ug/1 "
0.006 ug/1 "
0.001 ug/1
* samples taken monthly for one year from each river.

-------
      TABLE I (CONT.)  - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref   Agent
Source
Location
Concentration
00
ALKANES AND ALKENES
139 HEPTACHLOR EPOXIDE (cont.) Kanawha R., Winfield Dam, W. Va.
St. Lawrence R. , Massena, N.Y.
Lake Erie, Buffalo, N.Y.
Lake Superior, Duluth, Minn.
Mississippi R. , Cape Girardeau,
Mo.
St. Paul, Minn.
Fox R. , Green Bay, Wis.
N. Platte R., Henry, Nebr.
Platte R., Plattsmouth, Nebr.
S. Platte R. , Julesburg, Colo.
Mississippi R. , New Orleans, La.
Delta, La.
Trinity R., Livingston, Tex.
Bear R. , Preston, Idaho
37 Lake Erie, Buffalo, N.Y.
Lt. Lawrence R. , Massena, N.Y.
Delaware R. , Martin's Creek, Pa.
Potomac R. , Washington, D.C.
Great Falls, Md.
Schuylkill R. , Philadelphia, Pa.
Tombigbee R. , Columbus, Miss.
Tennessee R., Lenoir, Tenn.
presumptive Sept. 1966
0.003 ug/1
presumptive
0.010 ug/1
0.002 ug/1
0.004 ug/1
presumptive "
0.004 ug/1
presumptive "
0.019 ug/1 "
0.003 ug/1
0.007 ug/1
presumptive "
0.005 ug/1 "
0.002 ug/1 Sept. 1965
0.017 ug/1 "
presumptive
0.003 ug/1 "
presumptive
n "
n "
n -i

-------
      TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref   Agent
Source
                          Location
                                                                                              Concentration
                                                   ALKANES AND ALKENES
       37   HEPTACHLOR EPOXIDE (cont.)
                          Ohio R. , Cairo, 111.
                                   Addison, Ohio
                                 0.002 ug/1
                                 0.020 ug/1
                                                             Wabash R.,  New Harmony, Ind.     0.012 ug/1
                                                             Mississippi R., Burlington, Iowa presumptive
                                                                             Dubuque, Iowa    0.067 ug/1
                                                             Red R. (N), Grand Forks, N.D.    0.020 ug/1
                                                             Detroit R., Detroit, Mich.
                                                             Missouri R. , St. Louis, Mo.
                                                                          Kansas City, Kan.
<£>
                                                           presumptive
                                                           0.007 ug/1
                                                           0.014 ug/1
                                                           0.002 ug/1
                                                           presumptive
Platte R., Plattsmouth, Nebr.
Yellowstone R., Sidney, Mont.
Mississippi R., W. Memphis, Ark. 0.020 ug/1
Colorado R., Page, Ariz.         presumptive
Rio Grande, Brownsville, Tex.         "
Sabine R., Ruliff, Tex.               "
Yakima R., Richland, Wash.       0.002 ug/1
Sacramento R., Greens Landing,
Calif.                           0.019 ug/1
Mississippi R., W. Memphis, Ark. 0.020 ug/1
Missouri R., St. Louis, Mo.      0.002 ug/1
Mississippi R., New Orleans, La. 0.001 ug/1
St. Lawrence R., Massena, N.Y.   0.001 ug/1
Potomac R., Great Falls, Md.     <0.001 ug/1
Sept.
   n
                                                   ii
                                                   M
                                                                                                                   1965
                                                                                                             1958-65*
        * Highest levels during time studied

-------
   TABLE. I, (CQNT.)  -  CONCENTRATION OF ORGANIC POLLUTANTS  IN WATER
   Ref   Agent
                       Source
Location
Concentration
                                               ALKANES AND  ALKENES
   240   HEPTACHLOR EPOXIDE (cont.)
                                                 Missouri R.  at Nebraska City,
                                                 Nebr.
                                                 Yakima R. at Kiona,  Wash.
    23,   HEPTACHLORONORBORNENE  close to plants  manufac-  126  places  in Mississippi R.
    24                          turing endrin and hepta-  between Tiptonville,  Tenn.  and
             Cl                 chlor                     New  Orleans,  La.

                                manufacturers of endrin   Memphis Wolf  R.,  Cypress Creek
                                and heptachlor            Complex

                                                          below W. Memphis, Ark.
                                                                                           0.02  ug/1      June  1967
                                                                                           0.04  ug/1      June  1967
                                                                                  High
                                                                                  no residues in test sensi-
                                                                                  tive enough to detect 0.1 mg/1
00
o
   23
   24
HEXACHLORONORBORNADIENE  close to plants manu-
                       facturing endrin and
                       heptachlor
         •
-------
     TABLE L (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
                                  Source
Location
Concentration
oo
ALKANES AND ALKENES
24 ISODRIN (cent.) manufacturers of endrin Memphis Wolf R. , Cypress Creek
and heptachlor Complex
42 LINDANE pesticide
(y-BHC) agricultural Missouri R. at Nebraska City,
Cl ITobr. 0.005 ug/1*
Clvy/\^ci
Ji 1 Arkansas R. below John Martin
Cr^YiSl Reservoir, Colo. 0.005 ug/1*
Cl 0.010 ug/1*
0.005 ug/1*
0.010 ug/1*
0.005 ug/1*
0.010 ug/1*
0.010 ug/1*
at van Bur en, Ark. 0.005 ug/1*
0.005 ug/1*
0.010 ug/1*
0.005 ug/1*
0.005 ug/1*
Brazos R. at Richmond, Tex. 0.005 ug/1*


Colorado R. at Wharton, Tex. 0.010 ug/1*
0.005 ug/1*
0.020 ug/1*





Nov. 1965-
May 1966

Oct. 1965
Nov. 1965
Dec. 1965
Feb. 1966
March 1966
April 1966
May 1966
Dec. 1965
Feb. 1966
March 1966
April 1966
May, 1966
Feb. 1966
April 1966
May 1966
Jan. 1966
Feb. 1966
April 1966
                                                            Rio Grande below Anzalduas Dam,
                                                            Tex.                             0.010 ug/1*
                                                Oct. 1965
     * sample from each river taken monthly for two years.

-------
      TABLE I. (COOT.)  - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref   Agent
Source
Location
Concentration
                                                   ALKANES AND ALKENES
       42   LINDANE (cont.)
oo
      447


      259
cotton growing areas
                          Rio Grande below Anzalduas Dam,
                          Tex.
                                                             Colorado R.  (Yuma Main Canal)  at
                                                             Yuma,  Ariz.
                                                             Sacramento R.  at Verona,  Calif.
                                                             Yakima R.  at Kiona,  Wash.
                                                             Snake R.,  King Hill,  Idaho
                                                             Columbia R.,  Dalles,  Ore.
river water and municipal water
supply, Alabama

Lake Champlain
                                 0.005 ug/1*
                                 0.010 ug/1*
                                 0.005 ug/1*
                                 0.005 ug/1*
                                 0.010 ug/1*
                                 0.010 ug/1*
                                 0.005 ug/1*

                                 0.005 ug/1*
                                 0.005 ug/1*
                                 0.005 ug/1*

                                 0.005 ug/1*
                                 0.005 ug/1*
                                 0.005 ug/1
                                 0.010 ug/1*
                                 0.010 ug/1*
                                 0.005 ug/1*
                                 0.005 ug/1*

                                 0.005 ug/1*
                                 0.005 ug/1*
                                 0.005 ug/1*
                                 0.005 ug/1*
                                 0.020 ug/1*
               Nov. 1965
               Dec. 1965
               Jan. 1966
               Feb. 1966
               March 1966
               May 1966
               Aug. 1966

               March 1966
               April 1966
               May 1966

               March 1966
               April 1966
               May 1966
               March 1966
               April 1966
               May 1966
               July 1966

               April 1966
               Feb. 1966
               March 1966
               April 1966
               Aug. 1966
                                                           0.015-0.760 ug/1
                                                           0.015 ug/1     Oct. 1965
      * samples from each river taken monthly for period of one year.

-------
      TABLE L (CONT.) - CONCENTRATION OF ORGANIC POLIUTANTS IN WATER
oo
04
      448   TOXAPHENE
      259 8 (Cl)—fcH
      157    GLUCOSE
            C6H12°6
                                                                                              Concentration
ALKANES AND ALKENES
240 LINDANE (cont.) Arkansas R. below John Martin
Reservoir, Colo.
Brazos R. at Richmond, Tex.
Rio Grande below Ansalduas Dam,
Tex.
Pecos R. near Artesia, N. Hex.
Gila R. below Gillespie Dam,
Ariz.
Yakima'R. at Kiona, Wash.
24 pesticide formulating Horseshoe Bayou and Fish Lake at
0.01 ug/1*
0.02 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.02 ug/1*
0.02 ug/1*
0.02 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*

July 1968
May 1967
Dec. 1967
June 1967
Dec. 1967
Nov. 1967
Dec. 1967
Jan. 1968
March 1968
April 1968
May 1968
Sept. 1968
Oct. 1966
1966
                                   plant
Greenville, Jones Bayou at Cleve-
land and Sunflower R. at Clarks-
dale and Indianola

water supply in cotton growing
areas
Mohawk R.
Lake Erken, Sweden
0.0004 mg/1

0.00075 mg/1


less than 6 ug/1 all year
      * samples from each river taken monthly for two years.

-------
     TABLE L (COOT.) - CONCENTRATION OF ORGANIC  POLLUTANTS  IN  WATER
     Ref   Agent
                             Source
                          Location
                                 Concentration
oo
*-
ALIPHATIC

288   DIETHYLAMINE

      (C2H5)2NH


      DIMETHYLAMINE

      (CH3)2NH


      ETHYLAMINE

      C2H5NH2


      METHYLAMINE
                                                         AMINES
sewage from herbicides
and synthetic rubber
production

sewage from herbicides
and synthetic rubber
production

sewage from herbicides
and synthetic rubber
production

sewage from herbicides
and synthetic rubber
production
                                                             U.S.S.R.  - river water  sewage    up to 1000 mg/1    1967
                                                            U.S.S.R.  - river water  sewage    up  to 1000 mg/1    1967
                                                            U.S.S.R.  -  river water  sewage     up  to  1000 mg/1    1967
U.S.S.R. - river water sewage    up to 1000 mg/1    1967
AROMATIC

180   ANILINE
      (Phenyl-
      amine)

399   BENZIDINE
                      NH
                                  dye, varnish, rubber,
                                  chemical and gas-plant
                                  wastes

                                  dye and  pigment  facto
                                  ries
                          Kama R. (foreign)
                                 0-traces
                          Sumida R. (Japan), Senjyu Bridge 0.257 mg/1
                                         Shirahig Bridge   0.205 mg/1
                                         Odai Bridge       0.439 mg/1
                                                Dec. 1964

-------
      TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref   Agent
 Source
                                                       Location
                                 Concentration
00
Ul
                                                        AMINES
399   NAPHTHYLAMINE
                                   dye and pigment
                                   factories
      110   2,6-DICHLOROBENZONITRILE
            (Dichlobenil)          pesticide
      HETEROCYCLICS
       87   PYRIDINE
      CARBOXYLIC
      273   ACETIC  ACID
coke chemical plant's
waste water


waste water of gas
generating plants
Sumida R. (Japan) Odai Bridge    0.290 mg/1*
                  Senjyu Bridge  0.387 mg/1*
               Shirahige Bridge  0.275 mg/1*
                          irrigation waters in Colo.
                                                       Zaporozhye   U.S.S.R.
                                                       Dnepropetrovsk   U.S.S.R.
                                                       Ol'Khov      U.S.S.R.

                                                       Gomel glass  plant  U.S.S.R.
                                                       Dulev porcelain plant
                                                       Gus-Khrustal glass  plant
                                                       Tula "Podzemgas" Station
                                                    ORGANIC ACIDS
beet sugar, winery,
vinegar, soured-fruit,
wood distillation,
textile, or chemical
waste
                                                       Ohio R.

                                                       Lake Erken,  Sweden
                                                                                        8.82 ug/1
                                 9.6 mg/1
                                 17.4 mg/1
                                 5.0 mg/1

                                 22.4 mg/1
                                 15.0 mg/1
                                 23.4 mg/1
                                 15.6 mg/1
                                 25.2  ug/1
                                 <10 ug/1
                                                                          1964
      *  naphthylamine and benzidine

-------
   TABLE I (CONT.l -. CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
   Ref   Agent
Source
                                                      Location
Concentration
   273   BUTYRIC ACID
         (Butyrate)
                                                  ORGANIC ACIDS
used to decalcify
hides for varnishes
mfg. of esters in
artificial flavorings
                                                      Ohio R.
0.18 ug/1
   273   CAPROIC ACID
                          Ohio R.
                                                                                       2.5 ug/1
00
42   2,4-1
   240
agricultural
pesticide

agricultural
                   0-CH2-C-OH
                                                      Missouri R. at Nebraska City,
                                                      Nebr.
                                                          Yellowstone R. near Billings,
                                                          Mont.

                                                          James R. at Huron, S. D.
                                                          Arkansas R. below John Martin
                                                          Reservoir, Colo.
                                                                                           not present  in  rivers  studied
                                                                                           1965-1966  taken each month
                                                           0.07 ug/1*
                                                           0.12 ug/1*
                                                           0.08 ug/1*


                                                           0.02 ug/1*
                                                           0.07 ug/1*
                                                           0.07 ug/1*
                                                           0.08 ug/1*
                                                           0.11 ug/1*
                                                           0.35 ug/1*
                                                           0.19 ug/1*


                                                           0.04 ug/1*
                                                           0.24 ug/1*
               Dec. 1967
               May 1968
               June 1968


               May 1968
               Aug. 1968

               Oct. 1967
               April 1968
               June 1968
               July 1968
               Oct. 1968
                                                                                                      May 1968
                                                                                                      June 1968
   * samples taken every month for 1-2 years.

-------
      TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
                                   Source
                                                  Location
Concentration
oo
•vl
ORGANIC ACIDS
240 2,4-D (cont.) Arkansas R. at van riuren, Ark. 0.06 ug/1*
0.13 ug/1*
0.05 ug/1*
0.03 ug/1*
0.03 ug/1*
0.11 ug/1*
Canadian R. near Whitefield,
Okla. 0.06 ug/1*
0.01 ug/1*
Brazos R. at kichmond, lex. 0.01 ug/1*
0.06 ug/1*
0.07 ug/1*
0.11 ug/1*
Colorado R. at Wharton, Tex. 0.05 ug/1*
Green R. at Green River, Utah 0.06 ug/1*
Humboldt R. near Rye Patch, Nev. 0.08 ug/1*
Sacramento R. , Verona, Calif. 0.03 ug/1*
Yakima R. , Kiona, Wash. 0.18 ug/1*
0.30 ug/1*
0.05 ug/1*
0.24 ug/1*
0.33 ug/1*
0.21 ug/1*
0.29 ug/1*
Snake R. , King Hill, Idaho 0.14 ug/1*
0.06 ug/1*
0.05 ug/1*
0.10 ug/1*
Aug. 1967
Dec. 1967
April 1968
May 1968
June 1968
Aug. 1968
April 1968
May 1968
Sept. 1967
April 1968
May 1968
Tuly 1968
April 1968
oept. 1968
Aug. 1968
May 1968
Aug. 1967
Sept. 1967
April 1968
May 1968
June 1968
July 1968
Aug. 1968
Aug. 1967
Oct. 1967
June 1968
July 1968
      * all
samples taken every month for 1-2 years.

-------
      TABLE L (CONT.)  -  CONCENTRATION OF ORGANIC  POLLUTANTS  IN  WATER
      Ref   Agent
Source
                          Location
Concentration
00
00
      240   2,4-D
      CARBOXYLIC

      110   FENAC
             Cl   Cl
                        -OH
      273   FORMIC ACID
            (Formate)

            HCOOH
                                                      ORGANIC ACIDS
pesticide
                          Columbia R., Dalles, Ore.
                          irrigation water, Colo.
decalcifier, reducer in   Ohio R.
dying wool fast colors,
dehairing and pulping
hides, tanning, sizing
rubber processing
                                                           0.02 ug/1*
                                                           0.03 ug/1*
8.82 mg/1
               Nov. 1967
               May 1968
                                                           24.6 ug/1
       31   FULVIC ACID
                          10 samples from colored water    87.1% of total organics
                COOH 0
      273   ISOBUTYRIC ACID
                          Ohio R.
                                                           0.3 ug/1
            (CH3)2CHCOOH
        all samples taken every month for 1-2 years.

-------
      TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref   Agent
                             Source
                          Location
                                                                                               Concentration
      273   ISOVALERIC ACID
                                                     ORGANIC ACIDS
                                                       Ohio R.
                                                           0.22  ug/1
      273   PROPIONIC ACID
            (Propionate)
                             manufacturing of ester    Ohio R.
                             solvents fruit flavors,
                             perfume
                                                           0.38 ug/1
00
IO
325   TEREPHTHALIC ACID

       COOH-(   T-COOH
production of Laosan
waters, fibers
industrial reservoir
0.1 mg/1
       273   VALERIC ACID
                                                       Ohio R.
                                                           0.16 ug/1
       42   SILVEX
            (Kuron)
       240
                             pesticide
                          none found in western rivers
                          studied 1966
                          Brazos R., Richmond, Tex.
                                                             Colorado R., Whartcu, Tex.
                                                                                        G.U2 ug/1*
                                                                                        0.02 ug/1*
                                                                                        0.02 ug/1*
                                                Nov. 1966
                                                Aug. 1967
                                                Sept. 1967
                                                                                        0.01 ug/1*     Feb. 1968
       *  collected monthly for two years.

-------
      TABLE I (CONT).  - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
                                   Source
Location
                                 Concentration
ORGANIC ACIDS
240 SILVEX (cont.) Humboldt R., Rye Patch, Nev. 0.05 ug/1*
0.02 ug/1*
0.03 ug/1*
0.02 ug/1*
0.01 ug/1*
0.21 ug/1*
0.13 ug/1*
0.12 ug/1*
Sacramento R. , Verona, Calif. 0.01 ug/1*
Columbia R. , Dalles, Ore. 0.03 ug/1*
Oct. 1967
March 1968
April 1968
April 1968
June 1968
July 1968
Aug. 1968
Sept. 1968
Oct. 1967
Oct. 1966
VO
o
      440   2,4,5-T
       42
roof of Taft Center, Cincinnati
Ohio (rainwater)
Western Rivers studied 6 mos.
1966
Arkansas R. below John Martin
Reservoir, Colo.

            van Buren, Ark.
                                                             Canadian R. , Whitefield, Okla.
                                 0.04 mg/1
                                 none present
                                 0.02 ug/1*
                                 0.02 ug/1*
                                 0.02 ug/1*
                                 0.01 ug/1*
                                 0.04 ug/1*
                                 0.02 ug/1*
                                 0.02 ug/1*
                                 0.02 ug/1*
                                 0.02 ug/1*
                                 0.04 ug/1*
                                 0.04 ug/1*
                                 0.03 ug/1*
                                 0.02 ug/1*
Nov. 1967
July 1968
Sept. 1967
Nov. 1967
Dec. 1967
March 1968
April 1968
June 1968
July 1968
Aug. 1968
Dec. 1967
Feb. 1968
March 1968
      * samples taken monthly for 1-2 years.

-------
     TABLE, i CCQNT).  - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
 Source
 Location
 Concentration
vo
M
ORGANIC ACIDS
240 2,4,5-T (cont.) Canadian R. , Whitefield, Okla.
Brazos R. , Richmond, Tex.
Colorado R. , Wharton, Tex.
Pecos R., Artesia, N. Mex.
Green R. , Green River, Utah
Sacramento R. , Verona, Calif.
Yakima" R. , Kiona, Wash.
SULFONICS
69 ABS (Alkyl benzene detergent, industrial
sulfonate) waste
243 so- surfactants Italian surface water
20 /^\ anionic detergent Czechoslovakia
0.04 ug/1*
0.03 ug/1*
0.03 ug/1*
0.03 ug/1*
0.02 ug/1*
0.06 ug/1*
0.02 ug/1*
0.01 ug/1*
0.01 ug/1*
0.05 ug/1*
0.07 ug/1*
0.01 ug/1*
0.03 ug/1*
0.01 ug/1*
0.01 ug/1*
0.6 mg/1
3.5-100 mg/1
0.5 mg/1
April 1968
May 1968
July 1968
Sept. 1968
Aug. 1967
Sept. 1967
Oct. 1967
July 1968
April 1968
April 1968
Sept. 1968
Oct. 1967
Dec. 1967
Feb. 1968
Sept. 1967
    369
synthetic detergent
synthetic detergent
Worcestershire
Wise, well water
River and water supplies in 32
U.S. cities
0.03 mg/1
10 mg/1

<0.14 mg/1 av. = 0.024 mg/1
    * samples taken monthly 1-2 years.

-------
   TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
   Ref   Agent
Source
Location
                                                                                           Concentration
                                                  ORGANIC ACIDS
   297    ABS
          (cont.)
     4
    267
    78
   154
detergent
to
Michigan well waters (30 wells)
surface water
32 U.S. cities
111. streams
                          111. rivers
                          streams in Kansas
                          Ohio R. at Wheeling, W. Va.
                                     Cincinnati, Ohio
                          sewage in various cities
                          Ottawa, Kansas sewage
                          9 cities in Kansas  (sewage)
                          Aurora, 111. (sewage)
                          Indianapolis, Ind.  (sewage)
                          Benton Harbor, Mich.
                          Maiais des Cygnes R., Kan.
                          Neosha R., Kansas
                          Creek R., Kansas
                          U.S. average (average)
                          Tama R., Japan
                          Nogawa R., Japan
0.0-0.6 mg/1 (21 wells)
0.00-0.14 mg/1 (before 1961)
3.0 mg/1 highly polluted
         water
0.01 mg/1 unpolluted waters
0.5 mg/1
1.9-6.6 mg/1
up to 12 mg/1, daily average
      4 mg/1
0.1 mg/1
4-45 mg/1
39-44 mg/1
4.1-34 mg/1
45 mg/1
42 mg/1
8 mg/1
3.9-6.6 mg/1
1.0-1.9 mg/1
11 mg/1
10 mg/1
15:18  )  ratio of linear
20:80  )  alkylate sulfonates
25:75  )  to branch chain NBS
          measure by infra-red
          spectroscopy

-------
     TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
 Source
Location
                                                            Concentration
                                                    ORGANIC ACIDS
     396   ABS (linear)
     394
      32     SO'
detergent
                                  sewage water
     395    ABS  (MBAS)
VO
     161    ABS
    427

    395
anion detergent

14 waste processing
plants
Illinois R.
U.S. rivers
French cities
U.S. cities
Ruhr R.
Seine R.
Rhone R.
water works in England
Ohio R., Cincinnati, Ohio
most U.S. rivers prior to 1960
Illinois R.
           at Peoria (pre LAS)
           at Peoria (LAS)
Coons Rapids, upper Mississippi
R.
<0.01 mg/1
<0.01 mg/1
3.08-3.5 mg/1
1-15 mg/1
0.7-4.5 mg/1
0.125 mg/1
0.03 mg/1
0.5 mg/1
0.06-0.15 mg/1
0.01-0.02 mg/1
0.5-1.3 mg/1   1959
0.056 mg/1  Sept. 1959-June 1965
0.022 mg/1  July 1965-June 1966

<0.15 mg/1   1963-64
                                                            Spring  Lake,  upper Mississippi R.<0.49  mg/1
                                                            Upper Mississippi R.,  near  Spring
Lake
Modena(town sewage truckline)
      (outgoing canal)
Germany
                                                           Ohio R., Cincinnati, Ohio
up to 1.11 mg/1
23.18 mg/1
33.6 mg/1
5.4 mg/1
                                                                                                            1962-1964
                                                           0.06-0.15 mg/1
                                                    1965

-------
TABLE I (CQNT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
Source
Location
Concentration
395   ABS (cont.)
39
      MBAS (ABS & LAS)
                                               ORGANIC ACIDS
                          most rivers
                          Illinois R.

                          sewage works in England

                          waste processing plant, Germany
                          U.S. activated sludge plant


                          Illinois R.
                          community water supplies;
                          Camden, N.J.
                                                       rivers in U.S.
                                 0.01-0.02 mg/1
                                 >0.5 mg/1      1964
                                                                                        3.0 mg/1
                                                                                        1.3 mg/1
                                                1962  (pre LAS)
                                                1965  (post LAS)
                                 5.4 mg/1       1962  (pre LAS)
                                 5.0 mg/1  (pre) Sept. 1965
                                 0.7 mg/1  (post) Mar. 1965

                                 0.56 mg/1  (pre) Sept. 1959-
                                                 June 1965
                                 0.22 mg/1  (post) July 1965-
                                                 June 1966
                                 0.034 mg/1
                                 0.024 mg/1
                                 0.015 mg/1

                                 <0.5 mg/1
                                                                                                       Aug. 1959
                                                                                                       winter 1959
                                                                                                       spring 1960
                                              PHOSPHATE ESTERS
440   RONNELL
      (Trolene)
pesticides
Roof of Taft Center, Cincinnati,
Ohio (rainwater)                 0.2 mg/1
      CH^O

-------
      TABLE I X.CONT.)  - CONCENTRATION OF ORGANIC POLLUTANTS  IN WATER
      Ref   Agent
Source
                                                             Location
                                                           Concentration
                                                    PHOSPHATE ESTERS
      f> 03   Def
            (S,S,S-Tributyl-
             phosphorothioate)
chemical manufacturing
plant
outfalls of manufacturing plant
Ashlex R., Charleston Harbor, S.C.
                                                 1966
vo
      261   PHENYL  ETHER
      34,    1,2-BENZANTHRACENE*
      35
                                                          ETHERS
industrial waste from
perfuming soaps and
organic synthesis
St. Glair R., Ohio R.
                                                UNSUBSTITUTED AROMATICS
                          central portion of Rhine R.
                                 <10 mg/1
                                 10 & 18 ing/kg dry material
                                 from paper chromatqgraphy
                                 and absorption spectra
                                 respectively
       * value found is for combination of all these compounds

-------
     TABLE I  (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
Source
Location
Concentration
      34,   3,4-BENZOFLUORANTHENE*
      35
                                               UNSUBSTITUTED AROMATICS
                          central portion of Rhine R.
                                 10 & 18 mg/kg dry material
                                 from paper chromatography and
                                 absorption spectra respectively
vo
      34,   10,11-BENZOFLUORANTHENE*
      35
     34,   11,12-BENZOFLUORANTHENE *
     35
     32
                          central portion of Rhine R.
                          central portion of Rhine R.
                                 10 & 18 mg/kg dry material
                                 from paper chromatography and
                                 absorption spectra respectively
                                 10 & 18 mg/kg dry material
                                 from paper chromatography and
                                 absorption spectra respectively
                          sludge from Lake Constance       15 mg dry substance
     34,   1,12-BENZOPERYLENE *
     35
                          central portion of Rhine R.
                                 10 & 8 mg dry substance
     * value found is for combination of all these compounds

-------
    TABLE. I. (CONT.)  - CONCENTRATION  OF ORGANIC POLLUTANTS  IN WATER
    Ref   Agent
 Source
 Location
Concentration
   35    3,4-BENZOPYRENE
   336, 35
   34
   97
   409
vo
*"  32
   363
                                             UNSUBSTITUTED AROMA.TICS
industrial
(petroleum)
sewage from shale re-
fineries, coke plants,
petroleum refineries
sewage from thermal pro-1
cessing of shales
tunnel method on sewage
from thermal processing
of shales
coke gas plant
processing Kerosene
coke chemical plant
coke chemical plant
oil refinery
 drinking water
 central portion of  Rhine  R.
 Volga R. below Imeni P.I.
 Mendileeva  refinery
 sample of sand from filter
 of Novoyaroslavskii Waterworks
 U.S.S.R.
water supplies of above
U.S.S.R.  (plant effluent)

U.S.S.R.

sewage effluent


35 km downstream from plant

dried sediment from Seine R.
Lake Constance
Moscow region; absorbed into
soil and makes way to water
eventually consumed by man
                                                            0.01 ug/1
0.0001 ug/1

0.216 ug/kg dry sand
0.03-0.3 mg/1

0.001 mg/1
0.5 mg/1

9 mg/kg

0.13-0.29 mg/1
6 mg/1
0.52-0.63 mg/1
8.2-17.0 mg/kg (sediment from
                 river)
1.5 mg/100 g
15 mg/kg dry substance

-------
     TABLE. I (CONT.)  - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
                            Source
                          Location
                                 Concentration
VO
oo
      56

      32
     166
     3,4-EENZOPYRENE
     (cont.)
79
     348
                                               UNSUBSTITUTED AROMATICS
plants processing coke
and coal tar products
shale by-product manu-
facture
Slansty combine
coke by-product
coke-gas plant
Neflegaz plant
oil refinery
"Shist" plant resins
(effluents - untreated)
(effluents - treated)
                            effluent of petroleum
                            chemical enterprises
                            a.  eff. from thermal
                                cracking, coking &
                                pyrolysis
U.S.S.R. (plant effluent)

sludge from Lake Constance
U.S.S.R. effluent

U.S.S.R. effluent
U.S.S.R. effluent
U.S.S.R. effluent
U.S.S.R. effluent
U.S.S.R. effluent
U.S.S.R.
                                                            Plyasa R. (site of discharge)
                                                                      (3.5 km downstream)
                                                            U.S.S.R. Grozny
3 ug/1-0.29 mg/1

15 mg dry substance
0.1 mg/1

0.312 mg/1
0.04 mg/1
0.13-0.29 mg/1
3-0.03 mg/1
none

10.9 mg/kg
0.312 mg/kg
0.012 mg/kg
0.001 mg/kg
                                                           0.48-5.0 ug/1
                                  b.  calalytic cracking
                                                                                       0.05-0.29 ug/1

-------
     TABLE I (CQNT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
Source
Location
                                                           Concentration
                                               UNSUBSTITUTED AROMATICS
      34   CHRYSENE*
                          central portion of Rhine R.      10 & 18 mg/kg dry material
10
VO
      97    1,2,5,6-DIBENZANTHRA-   petroleum refineries
           CENE *
                          Volga R.,  U.S.S.R.
                          central portion of  Rhine R.
                                 not determined
                                 10 & 18 mg/kg dry material
           FLUORANTHENE*
           INDENO(1,2,3-cd)PYRENE *
                          central portion of Rhine R.       10 & 18 mg/kg dry material
                          central portion of Rhine R.       10 & 18 mg/kg dry material
     * value  found  is  for  combination of  all  these  compounds

-------
     TABLE 1  (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
            Source
Location
Concentration
           PYRENE*
                         UNSUBSTITUTED AROMATICS

                                      central portion of Rhine R.
                                 10 & 18 mg/kg dry material
     170    CRESOL
o
o
                           PHENOLS AND QUINONES

            distillation and chemical Poland (tap water)
(m-cresol)   treatment of coal tar or
            wood tar
(p-cresol)
(o-cresol)
                                 0.030 mg/1
                                 0.060 mg/1
                                 0.120 mg/1

                                 0.200 mg/1

                                 0.160 mg/1
      53   PENTACHLOROPHENOL

                 DH
            roof timbers sprayed
            (house)
cold water storage tank
     * value found is for combination of all  these compoundr

-------
   TABLE I. (CONT.)  - CONCENTRATION OF ORGANIC BOLLUTANTS  IN WATER
   Ref   Agent
                             Source
                                                         Location
                                                                                        Concentration
q
141
137
181


419

235
    16    PHENOLS  &  OIL
         RESIDUES
   246    PYROCATECHOL
          QH
              DH
                                              PHENOLS AND QUINONES
                                industrial and domestic   Hakensack R. basin
                                waste
                                                         Passaic R. basin
                                                         Elizabeth & Rahway R.
                                                         Raritan R. basin
                                                         Rhine R. at Ludwigshaven
                             waste water
                             waste water
                             industrial waste
                                tannery sewage
                                                         Poland  (tap water)
thermal processing of     U.S.S.R. (effluent)
oil shale
                          Missouri R., Omaha, Nebr.
                          (spring run-off)
certain parts of rivers   two regions of Rumania
not subject to industrial
pollution; suggests a
biogenic origin of
phenols in surface water
regenerator of the Syava  U.S.S.R. (effluent)
wood chemical factory
Amzya wood chemical       (effluent)
factory
                                                                                                       Nov.-Dec. 1962
NS-13.0 ug/1

NS-21.0 ug/1
NS-79.0 ug/1
NS-210.0 ug/1
0.40 mg/1
10-20 mg/1
0.050 mg/1
0.100 mg/1
0.200 mg/1
small amount
                                                                                           0.00-10.0 mg/1  1951-66
                                                                                          none
                                                                                        none

-------
     TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
Source
Location
Concentration
     246   PYROCATECHOL (cent.)
o
S3
               PHENOLS AND QUINONES

effluent from continuous  U.S.S.R
neutralization at the
Dimitrievskii wood chem-
ical factory

effluent from the washing U.S.S.R.
of pyrolyzate
wash water from ethyl
acetate manufacturing
wash water from Syava
wood chemical factory
total discharge from the
pumping station of the
Syava wood chemical
factory
general drain pit of the
tar-distillation shop of
the Syava wood chemical
factory

supposedly pure water

effluent from the alcohol
shop of  the  Syava wood
chemical factory
                                 none
                                                                                             1700 mg/1

                                                                                             350 mg/:
                                                                                             none
                                                                                             5 mg/1
                                                                                             1260 mg/1
                                                                                             none

                                                                                             traces

-------
 TABLE I C.CQNT.)  - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
Source
Location
                                                            Concentration
HALOGENATED
304 ODD
(TDE)
439 H
42 C1-C-C1
_/T\ I jf~\_




269
139



AROMATIC DERIVATIVES
spray 0.02 ppm for gnat Clear Lake, Calif.
control
pesticide Shenandoah R., Berry ville, Va.
agricultural Arkansas R. , John Martin
Reservoir, Colo.
van Buren, Ark.
Brazos R. , Richmond, Tex.
Rio Grande, Anzalduas Dam, Tex.
Sacramento R. , Verona, Calif.
Yakima R . , Kiona , Wash .
commercial orchard Knights Creek, Dunn County, Wis.
Connecticut R. , Enfield Dam,
Conn.
Hudson R. , Poughkeepsie, N.Y.
Narrows, N.Y.
Merrimack R., Lowell, Mass.
Delaware R. , Trenton, N.J.

0.083 ug/1
0.010 ug/1*
0.005 ug/1*
0.010 ug/1*
0.005 ug/1*
0.010 ug/1*
0.005 ug/1*
0.010 ug/1*
0.010 ug/1*
0.015 ug/1*
0.010 ug/1*
0.010 ug/1*
0.005 ug/1*
O.Olu ug/1*

0.013 ug/1
0.006 ug/1
0.005 ug/1
0.007 ug/1
presumptive

Sept. 1964
May 1966
March 1966
Aug. 1966
Feb. 1966
May 1966
Oct. 1965
Nov. 1965
May 1966
July 1966
Sept. 1966
Aug. 1966
June 1966
July 1966
June 1966
Sept. L96^
H
ii
it
* samples taken monthly.

-------
ft
II
TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER


Ref   Agent	Source	Location	Concentration	
                                            AROMATIC DERIVATIVES
139   ODD (cont.)                                      Schuylkill R.,  Philadelphia,  Pa.  0.009 ug/1   Sept.  1966
                                                       Delaware Bay                     0.005 ug/1
                                                                                        presumptive
                                                       Raritan R., Perth Amboy, N.J.    0.012 ug/1 (bottom)
                                                       Potomac R., Great Falls, N.Y.    0.012 ug/1      "
                                                       Susquehanna R., Conowingo,  Md.    0.003 ug/1      "
                                                                       Sayre, Pa.        0.005 ug/1      "
                                                       Neuse R., Raleigh, N.C.          0.006 ug/1      "
                                                       Apalachicola R., Chattahoochee,
                                                       Fla.                             presumptive
                                                       Chattahoochee R., Lanett, Ala.    0.011 ug/1      "
                                                       Savannah R., Port Wentworth,  Ga.  0.004 ug/1      "
                                                                    N. Augusta, Ga.      presumptive     "
                                                       Tennessee R.,  Bridgeport, Ala.    0.006 ug/1      "
                                                       Tombigbee R.,  Columbus, Miss.    0.008 ug/1      "
                                                       Kanawha R., Winfield Dam, W.  Va.  0.005 ug/1      "
                                                       Ohio R., Evansville, Ind.        0.003 ug/1      "
                                                                Addison, Ohio           0.004 ug/1      "
                                                       St. Mary's R.,  Sault Ste. Marie,
                                                       Mich.                            presumptive     "
                                                       Lake Superior,  Duluth, Minn.      0.005 ug/1      "
                                                       Maumee R., Toledo, Ohio          0.006 ug/1      "
                                                       Illinois R., Peoria, 111.        0.006 ug/1      "
                                                       Mississippi R., St. Paul, Minn.  0.006 ug/1      "

-------
TABLK Z (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
Source
Location
                                                           Concentration
                                            AROMATIC DERIVATIVES
139   ODD (cont.)
                          St.  Joseph R.,  Benton Harbor,
                          Mich.
                          Grand  R.,  Grand Haven, Mich.
                          Detroit R., Grosse Isle, Mich.
                          Fox  R., Green Bay, Wis.
                          Missouri R.,  St. Louis, Mo.
                                       Kansas City, Kan.
                          N. Platte  R., Henry, Nebr.
                          Platte R., Plattsmouth, Nebr.
                          S. Platte  R., Julesburg, Colo.
                          Rainy  R.,  Beaudette, Minn.
                          Red  R.  (N), Intern, boundary
                          Atchafalaya R.,  Morgan City, La.
                          Arkansas R.,  Pendleton Ferry,
                          Ark.
                                       Ponca City, Okla.
                          Mississippi R.,  Vicksburg, Miss.
                                          Delta, La.
                          Rio  Grande, Brownsville, Tex.
                                      El  Paso, Tex.
                                     Alamosa, Colo.
                          Sacramento R.,  Green's Landing,
                          Calif.
                          San  Joaquin R.,  Vernalis, Calif.
                                                                                        0.013 ug/1
                                                                                        0.009 ug/1
                                                                                        0.012 ug/1
                                                                                        0.007 ug/1
                                                                                        0.003 ug/1
                                                                                        0.010 ug/1
                                                                                        0.006 ug/1
                                                                                        0.005 ug/1
                                                                                        0.002 ug/1
                                                                                        0.005 ug/1
                                                                                        presumptive
                                                                                        0.010 ug/1

                                                                                        0.012 ug/1
                                                                                        0.005 ug/1
                                                                                        presumptive
                                                                                        0.008 ug/1
                                                                                        0.013 ug/1
                                                                                        0.009 ug/1
                                                                                        0.002 ug/1

                                                                                        0.009 ug/1
                                                                                        0.009 ug/1
                                              Sept. 1966
                                                 it
                                                 it

-------
TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
Source
Location
Concentration
                                            AROMATIC DERIVATIVES
139   DDD (cont.)
 37
                          Waikele Stream,  Oahu,  Hawaii
                          Snake R., Wawawai, Wash.
                          Spokane R.,  Post Falls Dam,
                          Idaho
                          Willamette R.,  Portland,  Ore.
                          Hudson R., Poughkeepsie,  N.Y.
                          Meriimack R.,  Lowell,  Mass.
                          St. Lawrence R., Massena, N.Y.
                          Delaware R., Trenton,  N.Y.
                          Potomac R.,  Washington, D.C.
                          Chattahoochee R., Lanett, Ala.
                          Savannah R., Port Wentworth, Ga.
                          Ohio R., Cairo,  111.
                                   above Addison, Ohio
                          Missouri R., Kansas City, Kans.
                          Platte R., Plattsmouth, Nebr.
                          Yellowstone R.,  Sidney, Mont.
                          Red R., Alexandria, La.
                          Brazos R., Arcola, Tex.
                          Rio Grande,  Brownsville,  Tex.
                          Williamette R.,  Portland, Ore.
                          Klamath R.,  Keno, Ore
                                 0.009 ug/1
                                 0.006 ug/1

                                 0.004 ug/1
                                 0.003 ug/1
                                 presumptive
                                 0.007 ug/1
                                 0.010 ug/1
                                 0.018 ug/1
                                 0.007 ug/1
                                 0.012 ug/1
                                 0.006 ug/1
                                 0.003 ug/1
                                 presumptive
                                 0.011 ug/1
                                 0.010 ug/1
                                 0.005 ug/1
                                 0.008 ug/1
                                 presumptive
                                 0.026 ug/1
                                 0.013 ug/1
                                 presumptive
               Sept.  1966
               Sept. 1965

-------
 TABLE  X
                - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
Source
Location
                                                           Concentration
AROMATIC DERIVATIVES
37 DDD (cont.) Waikele Stream, Hawaii
Delaware R. , Philadelphia, Pa.
Savannah R., N. Augusta, S.C.
Rio Grande, Brownsille, Tex.
El Paso, Tex.
Mississippi R. , New Roads, La.
Red R. , Alexandria, La.

San Joaquin R. , Vernalis , Calif .
Rio Grande, Laredo, Tex.
Apalachicola.R. , Chattahoochee,
Fla.
Sacramento R. , Green's Landing,
Calif .
156 Cle-ar Lake, Calif.
259 Maximum value in Niagara R.

U.S. surface waters
240 Arkansas R. , van Buren, Ark.
Canadian R. , Whitefield, Okla.
Brazos R., Richmond, Tex.





0.008 ug/1
0.080 ug/1
0.031 ug/1
0.019 ug/1
0.012 ug/1
0.012 ug/1
0.011 ug/1

0.010 ug/1
0.009 ug/1

0.008 ug/1

0.006 ug/1

0.083 ug/1
no trace since
0.006 ug/1
0.01 ug/1*
0.01 ug/1*
0.03 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*

Sept. 1965
1958-1965
CAM samples
Top ten


1958-1965
CAM samples
Top ten







Aug. 1964
1964
Sept. 1965
May 1967
Dec. 1967
May 1967
Oct. 1967
Jan 1968
March 1968
July 1968
* sample taken monthly for 2 years.

-------
     TABLE I CCQNT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
Source
Location
Concentration
                                                 AROMATIC DERIVATIVES
     240   DDD (cont.)
                          Colorado R., Wharton, Tex.
                                                            Rio Grande, Anzalduas Dam, Tex.
                                                            Gila R., Gillespie Dam, Ariz.
o
oo
                                                            Sacramento R., Verona, Calif.

                                                            Yakima R., Kiona, Wash.
                                                            Columbia R.,  Dalles, Ore.
                                 0.01 ug/1*
                                 0.01 ug/1*
                                 0.04 ug/1*
                                 0.01 ug/1*
                                 0.01 ug/1*
                                 0.01 ua/l*
                                 0.01 ug/j.*
                                 0.01 ug/1*
                                 0.01 ug/1*

                                 0.01 ug/1*
                                 0.02 ug/1*
                                 0.01 ug/1*
                                 0.02 ug/1*
                                 0.01 ug/1*
                                 0.01 ug/1*
                                 0.01 ug/1*
                                 0.02 ug/1*
                                 0.02 ug/1*
                                 0.01 ug/1*
                                 0.02 ug/1*
                                 0.01 ug/1*
                                 0.01 ug/1*
                                 0.02 ug/1*
                                 0.01 ug/1*
                                 0.01 ug/1*
                                 0.01 ug/1*
                                 0.01 ug/1*
               June 1967
               Nov. 1967
               Jan. 1968
               Feb. 1968
               March 1968
               July 1968
               Aug. 1968
               June 1967
               Oct. 1967

               Nov. 1967
               Dec. 1967
               March 1968
               May 1968
               June 1968
               Sept. 1968
               Nov. 1966
               Jan. 1967
               April 1967
               Oct. 1967
               Dec. 1967
               Feb. 1968
               June 1968
               July 1968
               Aug. 1968

               Oct. 1966
               Nov. 1967
               Jan. 1968
     * samples taken monthly for two years.

-------
      TABLE 1 (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
Source
Location
                                                                                             Concentration
                                                 AROMATIC DERIVATIVES
o
vo
                          roof of Taft Center,  Cincinnati,
                          Ohio (rainwater)
                          Connecticut R., Northfield,  Mass
                          Hudson R.,  Poughkeepsie,  N.Y.
                          St.  Lawrence R.,  Massena, N.Y.
                          Delaware R., Martin's Creek, Pa.
                          Potomac R.,  Great Falls,  Md.
                          Shenandoah  R., Berryville, Va.
                          Savannah R., Port Wentworth, Ga.
                                       N. Augusta,  S.C.
                          Tennessee R., Bridgeport, Ala.
                          Kanawha R.,  Winfield  Dam, W. Va.
                          Monongahela  R., Pittsburgh,  Pa.
                          Maumee  R., Toledo, Ohio
                          Mississippi  R., Burlington,  Iowa
                                         Lock  & Dam 3,
                          St.  Paul, Minn.
                          Rainy R., Baudette, Minn.
                          Red  R.  (N),  Grand Forks,  N.D.
                          St.  Clair R., Port Huron, Mich.
                          Lake Superior, Duluth, Minn.          "
                          Big Horn R.,  Hardin, Mont.            "
                         Missouri R.,  Yankton, S;D.       0.004 ug/1
                                                                                             0.2 mg/1
                                                                                             presumptive
                                                                                             0.004 ug/1
                                                                                             presumptive
                                                                                             0.008 ug/1
                                                                                             presumptive
                                                                                             0.002 ug/1
                                                                                             0.004 ug/1
                                                                                             presumptive
                                                                                             0.004 ug/1
                                                                                             0.015 ug/1
                                                                                             presumptive
                                                                                             0.011 ug/1
                                                                                             presumptive
                                                                                             0.004 ug/1
                                                                                             presumptive
                                                Sept. 1964
                                                  n

-------
TABLE. I (CONT). - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref Agent Source Location
AROMATIC DERIVATIVES
439 DDE (cont.) Missouri R. , Bismarck, N.D.
Platte R., Plattsmouth, Nebr.
S. Platte R., Julesburg, Colo.
(N. channel)
Arkansas R. , Little Rock, Ark.
Mississippi R. , New Roads, La.
Vicksburg, Miss.
W. Memphis, Ark.
Atchafalaya R. , Morgan City, La.
Colorado R. , Yuma, Ariz.
Green R. , Dutch John, Utah
Rio Grande, Brownsville, Tex.
Alamo sa , Colo .
Columbia R., Clatskanie, Ore.
Pas co, Wash.
Snake R., Wawawai, Wash.
Payette, Idaho
San Joaquin R. , Vernalis, Calif.
Bear R. , Preston, Idaho
Arkansas R., John Martin
Reservoir, Colo.
van Buren, Ark.
Concentration
0.003 ug/1
0.004 ug/1
0.018 ug/1
presumptive
presumptive
n
0.007 ug/1
0.003 ug/1
0.004 ug/1
presumptive
n
n
0.005 ug/1
presumptive
0.005 ug/1
0.005 ug/1
0.011 ug/1
0.005 ug/1
0.005 ug/1
0.015 ug/1
0.020 ug/1
0.005 ug/1

Sept.
n
n
"
M
it
M
n
M
II
II
II
II

1964












Oct. 1965
May 1966
July 1966
Oct. 1965
March 1966

-------
 TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN HATER
Ref Agent Source Location
AROMATIC DERIVATIVES
42 DDE (cont.) Brazos R. , Richmond, Tex.
Colorado R. , Wharton, Tex.
Rio Grande, Anzalduas Dam, Tex.
Colorado R. , Yuma, Ariz.
Yakima R. , Kiona, Wash.
269 commercial orchard Knight's Creek, Dunn County, Wis
Concentration
0.005 ug/1
0.010 ug/1
0.015 ug/1
0.005 ug/1
0.005 ug/1*
0.005 ug/1*
0.010 ug/1*
0.010 ug/1*
0.005 ug/1*
0.010 ug/1*
0.010 ug/1*
0.010 ug/1*
0.015 ug/1*
»

April 1966
Aug. 1966
April 1966
May 1966
Oct. 1965
Feb. 1966
May 1966
Aug. 1966
May 1966
June 1966
April 1966
May 1966
July 1966
June 1966
                             amount pesticide applied
                             not determined 1963-65
139
                                                       Hudson R. , Poughkeepsie, N.Y.
                                                                  Narrows, N.Y.
                                                       Tennessee R. , Bridgeport, Ala.
                                                       St. Lawrence R. , Massena, N.Y.
                                                       Lake Superior, Duluth, Minn.
                                                       Arkansas R., Pendleton Ferry,
                                                       Ark.
                                                       Brazos R. , Arcola, Tex.
                                                       Red R. , Alexandria, La.
presumptive    Sept. 1966

     M           ii
0.002 ug/1       "
presumptive      "
     ii           ii
0.004 ug/1       "
presumptive      "
* sample taken monthly.

-------
TABLE I (CQNT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
Source
Location
                                                           Concentration
                                            AROMATIC DERIVATIVES
139   DDE (cont.)
 37
448

259
                          Rio Grande, El Paso,  Tex.
                          San Joaquin R., Vernalis,  Calif.
                          Columbia R., Clatskanie,  Ore.
                          Rainy R., Baudette, Minn.
                          Detroit R., Detroit,  Mich.
                          Platte R., Plattsmouth, Nebr.
                          Yellowstone R., Sidney, Mont.
                          San Juan R., Shiprock, N.  Mex.
                          Delaware R., Philadelphia, Pa.
                          Mississippi R., Vicksburg, Miss.

                          Hudson R., Poughkeepsie,  N.Y.
                          S.  Platte R., Julesburg,  Colo.
                          Mississippi R., N.  Orleans, La.
                          Rio Grande, Brownsville,  Tex.
                                      Laredo, Tex.
                          Lake Superior, Duluth, Minn.
                          12  stations in various river
                          basins
                          samples from 100 locations in
                          U.S.
                          Seneca R.
                          Lake Champlain
                                                Sept. 1966
                                                Sept. 1965
                                                                                                       CAM samples top
                                                                                                       ten 1958-65
presumptive
0.003 ug/1
0.001 ug/1
presumptive
0.008 ug/1
presumptive
0.002 ug/1
0.009 ug/1
0.012 ug/1
0.011 ug/1

0.006 ug/1
0.005 ug/1
0.004 ug/1
0.004 ug/1
0.004 ug/1
0.004 ug/1

0.002 ug/1
                                 0.000-0.018 ug/1 "
                                 0.011 ug/1     Sept. 1965
                                 0.011 ug/1     Oct. 1965
                                                                                                         I!

                                                                                                         It

-------
TABLE. I. CCONT.) - CONCENTRATION OF ORGANIC POLLUTANTS  IN WATER
Ref   Agent
Source
Location
Concentration
AROMATIC DERIVATIVES
240 DDE (cont.) Missouri R., Nebraska City,
Nebr. 0.01 ug/1
Arkansas R. , van Buren, Ark. 0.01 ug/1*
0.01 ug/1*
Brazos R., Richmond, Tex. 0.01 ug/1*
0.01 ug/1*
0.06 ug/1*
0.01 ug/1*
0.01 ug/1*
0.02 ug/1*
0.01 ug/1*
0.02 ug/1*
0.01 ug/1*
0.01 ug/1*
Colorado R. , Wharton, Tex. 0.01 ug/1*
0.02 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
Rio Grande, Ansalduas Dam, Tex. 0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.02 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
Gila R., Gillespie Dam, Ariz. 0.03 ug/1*
0.03 ug/1*


May 1967
April 1967
May 1967
Nov. 1966
May 1967
June 1967
Oct. 1967
Dec. 1967
Jan. 1968
March 1968
May 1968
July 1968
Sept. 1968
June 1967
Jan. 1968
March 1968
April 1968
July 1968
Aug. 1968
Feb. 1967
March 1967
June 1967
Oct. 1967
Nov. 1967
Dec. 1967
May 1968
Sept. 1968
Nov. 1967
Dec. 1967
* samples taken monthly for 1-2 years.

-------
TABLE. I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
                             Source
                          Location
Concentrat ion
AROMATIC DERIVATIVES
240 DDE (cont.) Gila R. , Gillespie Dam, Ariz. 0.01 ug/1*
0.03 ug/1*
0.02 ug/1*
0.04 ug/1*
0.03 ug/1*
0.05 ug/1*
0.03 ug/1*
Sacramento R. , Verona, Calif. 0.01 ug/1*
Yakima R. , Kiona, Wash. 0.01 ug/1*
0.03 ug/1*
0.01 ug/1*
0.02 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.02 ug/1*
0.01 ug/1*
0.01 ug/1*
Columbia R., Dalles, Ore. 0.01 ug/1*

Jan. 1968
Feb. 1968
March 1968
May 1968
June 1968
July 1968
Sept. 1968
May 1968
Feb. 1967
June 1967
Oct. 1967
Dec. 1967
Jan. 1968
Feb. 1968
May 1968
June 1968
July 1968
Aug. 1968
Nov. 1967
436      \==
433
                             rainwater
mosquito control
                                                       Mississippi R., Quincy, 111.     1-20 ug/1
                                                       run off                          0.02-0.06 ug/1
                                                       roof of Taft Center, Cincinnati,
                                                       Ohio
                                                                                        1.2 ug/1
                                                       48 areas Salt Lake County, Utah
                                                       rivers, creeks, canals, ditches, 1.4-4.6 ug/1
                                                       drainage areas, etc.             3.6-2.8 ug/1
                                                                                                       March 1965
                                                       Angara
                                                           0.005-0.04 mg/1
* camples taken monthly for 1-2 years,

-------
      TABLE  I (CONT.)  -  CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref    Agent
Source
Location
 Concentration
                                                 AROMATIC DERIVATIVES
      280   DDT  (cont.)
      290
      17
      445
      439
0.5 Ib/acre
H
                          Ukranian water reservoirs
rivers in U.S.
Sabago Lake, Maine
Boulder R. drainage area, Mont.
Connecticut R., Northfield, Mass
Potomac R., Great Falls, Md.
Shenandoah R., Berryville, Pa.
Susquehanna R., Sayre, Pa.
Apalachicola R., Chattahoochee,
Fla.
Chattahoochee R., Lanett, Ala.
Savannah R., Port Wentworth, Ga.
Clinch R., Kingston, Tenn.
Tennessee R., Bridgeport, Ala.
Kanawha R., Winfield Dam, W. Va.
Monongahela R., Pittsburgh, Pa.
Wabash R., New Harmony, Ind.
Maumee R., Toledo, Ohio
Mississippi R., Burlington, Iowa
                Lock & Dam 3,
St. Paul, Minn.
 0.01-0.04 mg/1
 0.02-0.07 mg/1
 traces  - 0.03 mg/1
 1.6-3.4 mg/1
 0.001-0.2 mg/1
 0.02  mg/1
.presumptive
      it
 0.026 ug/1
 presumptive

 0.027 ug/1
 0.007 ug/1
 0.020 ug/1
 presumptive
      ii
 0.017 ug/1
 0.018 ug/1
 presumptive
 0.087 ug/1
 presumptive
                                                                          Sepu. 1964

-------
TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
Source
Location
                                                                                        Concentration
                                            AROMATIC DERIVATIVES
439   DDT (cont.)
                          Rainy R.,  Baudette,  Minn.
                          Red R. (N),  Grand Forks, N.D.
                          Lake Michigan, Milwaukee,  Wis.
                          Lake Superior, Duluth, Minn.
                          Missouri R., Yankton, S.D.
                                       Bismarck, N.D.
                          Platte R., Plattsmouth, Nebr.
                          Arkansas R., Little Rock,  Ark.
                          Mississippi R., New Roads, La.
                                          Vicksburg, Miss.
                          Red R. (S),  Alexandria, La.
                          Atchafalaya R., Morgan City, La.
                          Colorado R., Yuma, Ariz.
                                       Loma, Colo.
                          Green R.,  Dutch John, Utah
                          Rio Grande,  Brownsville,  Tex.
                                      Alamosa, Colo.
                          Clearwater R., Lewiston,  Idaho
                          Columbia R., Clatskanie,  Ore.
                                       Pasco, Utah
                          Pend Oreille R., Albeni Falls
                          Dam, Idaho
                          Snake R.,  Wawawai, Wash.
                                    Payette, Idaho
                                 presumptive
                                 0.072 ug/1
                                 presumptive
                                      tt
                                 0.024 ug/1
                                 0.014 ug/1
                                 0.019 ug/1
                                 presumptive
                                      it
                                 0.041 ug/1
                                 0.031 ug/1
                                 0.047 ug/1
                                 0.021 ug/1
                                 presumptive
                                      n
                                 0.025 ug/1
                                 presumptive
                                 0.012 ug/1
                                 0.034 ug/1
                                 presumptive
                                                                                        0.014 ug/1
                                                                                        presumptive
Sept. 1964
                                                    n
                                                    n

-------
TABLE Z CCONT;) - CONCENTRATION OF ORGANIC POLLUTANTS  IN WATER
Ref   Agent
Source
Location
Concentration
AROMATIC DERIVATIVES
439 DDT (cont.) Willamette R., Portland, Ore.
Klamath R. , Keno, Ore.
Sacramento R. , Green's Landing,
Calif.
San Joaquin R., Vernalis, Calif.
Bear R. , Preston, Idaho
369 Detroit, Missouri & Mississippi
Rivers
42 agricultural Missouri R. at Nebraska
Arkansas R. , John Martin
Reservoir, Colo.
van Bur en, Ark.
Brazos R. , Richmond , Tex .
Colorado R. , Wharton, Tex.
Rio Grande, Anzalduas, Tex.
Colorado R. , Yuma, Ariz.
Yakima R., Kiona, Wash.
Snake R., King Hill, Idaho
128 1 Ib/acre nearby streams
0.029 ug/1
0.016 ug/1
presumptive
0.066 ug/1
0.034 ug/1
0.001-0.2 mg/1
0.050 ug/1
0.045 ug/1
0.075 ug/1
0.070 ug/1
0.110 ug/1
0.055 ug/1
0.045 ug/1
0.105 ug/1
0.025 ug/1
0.070 ug/1
0.050 ug/1
0.070 ug/1
0.065 ug/1
0.060 ug/1

Sept. 1964
ii
ii
ii
ii
ii
May 1966
Sept. 1966
May 1966
July 1966
Aug. 1966
May 1966
June 1966
Aug. 1966
Oct. 1965
April 1966
July 1966
March 1966
Aug. 1966
July 1966

                             watersheds in Pa.

-------
       TABLE I  (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
       Ref   Agent
Source
Location
Concentration
                                                   AROMATIC DERIVATIVES
       139   DDT  (cont.)
oo
                          Hudson R.,  Poughkeepsie, N.Y.
                                     Narrows,  N.Y.
                          Delaware R.,  Trenton, N.J.
                          Potomac R., Great Falls, Md.
                          Susquehanna R.,  Sayre, Pa.
                          Neuse R.,  Raleigh, N.C.
                          Escambia R.,  Century, Fla.
                          Tennessee  R.,  Bridgeport,  Ala.
                          Ohio R., Cairo,  111.
                          Wabash R.,  Lafayette, Ind.
                          Lake Superior,  Duluth, Minn.
                          Missouri R.,  Kansas City, Kans.
                                       Bismarck, N.D.
                          Platte R.,  Plattsmouth, Nebr.
                          Rainy R.,  Beaudette, Minn.
                          Arkansas R.,  Pendleton Ferry,
                          Ark.
                                       Coolidge, Kans.
                          Brazos R.,  Arcola, Tex.
                          Mississippi R.,  Vicksburg,  Miss.
                                          Delta, La.
                          Rio Grande, Brownsville, Tex.
                                      El  Paso, Tex.
                                 0.005 ug/1
                                 0.007 ug/1
                                 0.028 ug/1
                                 0.038 ug/1
                                 0.010 ug/1
                                 presumptive
                                 0.020 ug/1
                                 0.007 ug/1
                                 0.026 ug/1
                                 0.029 ug/1
                                 0.013 ug/1
                                 0.023 ug/1
                                 0.015 ug/1

                                 0.042 ug/1
                                 presumptive
                                 0.123 ug/1
                                 0.044 ug/1
                                 0.031 ug/1
                                 presumptive
                                 0.046 ug/1
               Sept. 1966
                   it

-------
TABLE I CCONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
Ref   Agent
Source
Location
Concentration
                                            AROMATIC DERIVATIVES
139   DDT (cont.)
147
102

 37
                          Colorado R.,  Page,  Ariz.
                          Kiikii Stream,  Oahu,  Hawaii
                          San Joaquin  R.,  Vernalis,  Calif.
                          Waikele Stream,  Oahu, Hawaii
                          Pend Oreille R., Albeni Falls
                          Dam, Idaho
                          Snake R., American  Falls,  Idaho
                          Willamette R.,  Portland, Ore.
                          large U.S. rivers
                          Lake St.  Clair,  Ont., Detroit R.
                          Mississippi  & Missouri rivers
                             x
                          Chattahoochee R., Lanett,  Ala.
                          Escambia R.,  Century, Fla.
                          Savannah R.,  Port Wentworth,  Ga.
                          Clinch R., Kingston,  Tenn.
                          Tennessee R., Bridgeport,  Ala.
                          Allegheny R., Pittsburgh,  Pa.
                          Monongahela R.,  Pittsburgh,  Pa.
                          Ohio R.,  Cairo,  111.
                                   Addison, Ohio
                          Wabash R., New Harmony,  Ind.
                          Illinois  R.,  Peoria,  111.
                                 presumptive
                                 0.013 ug/1
                                 0.007 ug/1
                                 0.013 ug/1

                                 presumptive
                                 0.025 ug/1
                                 0.018 ug/1
                                 0.02 mg/1
                                 1-20 ug/1
                                 1-20 ug/1
                                 0.017 ug/1
                                 0.017 ug/1
                                 0.016 ug/1
                                 presumptive
                                 0.015 ug/1
                                 0.004 ug/1
                                 0.016 ug/1
                                 0.023 ug/1
                                 presumptive
                                 0.012 ug/1
                                 presumptive
              Sept.  1966
               1953
               1957
              Sept. 1965

-------
       TABLE I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS  IN WATER
       Ref   Agent
Source
Location
Concentration
                                                   AROMATIC DERIVATIVES
        37   DDT (cont.)
NJ
O
                          Mississippi R.,  E.  St.  Louis,
                          111.
                          Red R.  (N), Grand Forks,  N.D.
                          Missouri R., St. Louis, Mo.
                          N.  Platte R., Henry,  Nebr.
                          S.  Platte R., Julesburg,  Colo.
                          Yellowstone R'.,  Sidney, Mont.
                          Mississippi R.,  Vicksburg, Miss.
                                          Delta,  La.
                          Colorado R., Page,  Ariz.
                          San Juan R., Shiprock,  N. Hex.
                          Rio Grande, El Paso,  Tex.
                                      Alamosa,  Colo.
                          Spokane R., Post Falls  Dam,
                          Idaho
                          Truckee R., Farad,  Calif.
                          (Nevada border)
                          Rio Grande, Brownsville,  Tex.
                                      Laredo, Tex.
                                      El Paso,  Tex.
                          Ohio R., Cairo,  111.
                          Mississippi R.,  New Orleans, La.
                          Delaware R., Philadelphia, Pa.
                          Chattahoochee R., Lanetts Ala.
                                 presumptive
                                 0.034 ug/1
                                 0.016 ug/1
                                 0.039 ug/1
                                 0.023 ug/1
                                 0.002 ug/1
                                 0.017 ug/1
                                 0.019 ug/1
                                 0.058 ug/1
                                 0.125 ug/1
                                 0.012 ug/1
                                 0.149 ug/1

                                 0.037 ug/1

                                 presumptive
                                 0.144 ug/1
                                 0.052 ug/1
                                 0.032 ug/1
                                 0.023 ug/1
                                 0.019 ug/1
                                 0.015 ug/1
                                 0.011 ug/1
                                                                                                             Sept. 1965
                                                                                                              top ten
                                                                                                              CAM samples
                                                                                                              1958-1965

-------
 TABLE  I (CONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
 Ref   Agent
Source
Location
                                                           Concentration
                                            AROMATIC DERIVATIVES
 37   DDT  (cont.)
448


240
                          Tennessee R.,  Pickwick Landing,
                          Tenn.
                          Mississippi R. ,  Vicksburg, Miss.

                          Sacramento R., Green's Landing
                          Calif.

                          Tombigbee R.,  Columbus, Miss.

                          analysis of water at 100 loca-
                          tions  across U.S.
                          Missouri R., Nebraska City,
                          Nebr.
                                                       Platte R., Brady, Nebr.

                                                       Arkansas R., John Martin
                                                       Reservoir, Colo.
                                                                    van Buren, Ark.
                                                       Canadian R.,  Whitefield, Okla.
                                                       Brazos R.,  Richmond, Tex.
                                 0.011 ug/1     1958-65
                                 0.010 ug/1        "

                                 0.009 ug/1        "
                                 0.009 ug/1

                                 0.000-0.087 ug/1  "
                                 0.01 ug/1*
                                 0.01 ug/1*
                                 0.09 ug/1*

                                 0.01 ug/1*


                                 0.01 ug/1*
                                 0.01 ug/1*
                                 0.04 ug/1*
                                 0.01 ug/1*
                                 0.01 ug/1*
                                 0.01 ug/1*
                                 0.01 ug/1*

                                 0.01 ug/1*
                                 0.01 ug/1*
                                 0.01 ug/1*

                                 0.08 ug/1*
                                 0.07 ug/1*
                                 0.01 ug/1*
April 1967
Dec. 1967
May 1968
Jan. 1968

Oct. 1967
Dec. 1967
July 1968
April 1967
Nov. 1967
Dec. 1967
Sept. 1968
Dec. 1967
Jan. 1968
Sept. 1968
Nov. 1966
Dec. 1966
May 1967
* samples taken monthly for two years.

-------
       TABLE I CCQNT.)  - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
NJ
Ref Agent Source Location Concentration
AROMATIC DERIVATIVES
240 DDT (cont.) Brazos R. , Richmond, Tex. 0.06 ug/1*
0.01 ug/1*
0.01 ug/1*
0.04 ug/1*
0.01 ug/1*
0.02 ug/1*
0.01 ug/1*
Colorado R., Wharton, Tex. 0.03 ug/1*
0.04 ug/1*
0.01 ug/1*
0.12 ug/1*
0.03 ug/1*
0.05 ug/1*
0.04 ug/1*
0.09 ug/1*
0.02 ug/1*
0.01 ug/1*
Rio Grande, Anzalduas Dam, Tex. 0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
Colorado R., Yuma, Ariz. 0.01 ug/1*
0.01 ug/1*
Green R. , Green River, Utah 0.01 ug/1*
0.01 ug.l*
Gila R., Gillespie Dam, Ariz. 0.03 ug/1*
0.07 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.03 ug/1*
0.04 ug/1*

June 1967
Oct. 1967
Dec. 1967
Jan. 1968
March 1968
July 1968
Sept. 1968
June 1967
Oct. 1967
Nov. 1967
Jan. 1968
Feb. 1968
March 1968
April 1968
May 1968
July 1968
Aug. 1968
Oct. 1967
Nov. 1967
Dec. 1967
Nov. 1967
Jan. 1968
Nov. 1967
Jan. 1968
Nov. 1967
Dec. 1967
Jan. 1968
March 1968
May 1968
July 1968
Sept. 1968
       * samples taken monthly for  two  years,

-------
TABLE r. (CONT.) - CONCENTRATION  OF ORGANIC POLLUTANTS IN WATER
Ref Agent Source Location Concentration
AROMATIC DERIVATIVES
240 DDT (cont.) Humboldt R., Rye Patch, Nev. 0.06 ug/1*
0.02 ug/1*
Sacramento R., Verona, Calif. 0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.05 ug/1*
0.02 ug/1*
Feather R. , Oroville, Calif. 0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
Yakima R., Kiona, Wash. 0.02 ug/1*
0.03 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.03 ug/1*
0.03 ug/1*
0.02 ug/1*
0.02 ug/1*
0.02 ug/1*
Snake R., King Hill, Idaho 0.02 ug/1*
0.01 ug/1*
0.01 ug/1*
0.02 ug/1*
Columbia R. , Dalles, Ore. 0.01 ug/1*
0.01 ug/1*
0.01 ug/1*
0.01 ug/1*

Jan 1968
March 1968
Oct. 1967
Nov. 1967
Dec. 1967
Jan. 1968
May 1968
July 1968
Oct. 1967
Jan. 1968
March 1968
April 1967
June 1967
Oct. 1967
Nov. 1967
Dec. 1967
Jan. 1968
Feb. 1968
March 1968
April 1968
May 1968
June 1968
July 1968
Aug. 1968
Oct. 1967
Dec. 1967
Jan. 1968
Oct. 1968
June 1967
Nov. 1967
Jan. 1968
May 1968
 samples  taken monthly 1-2 years.

-------
      TABLE I (CQNT.l - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
      Ref   Agent
Source
Location
                                                                                              Concentration
      432   DDT (cont.)
        24   DDT AND ANALOGUES
       38
S3
      432   HEXACHLORANE
            (HCB)

              Cl   Cl
                                                  AROMATIC DERIVATIVES
municipal and agri-
cultural

formulation wastes
and/or agricultural

applied to foliage,
water courses
      U.S.S.R.:  open bodies of water
                water supply sources

      streams in Louisiana, Missis-
      sippi and Arkansas
      Coldwater Creek, Mississippi
      Bear Creek, Mississippi
soil  Susquehanna R., Conowingo, Md.
      Delaware R., Philadelphia, Pa.
      Chattahoochee R., Lanett, Ala.
      Tennessee R., Pickwick Ldg., Tenn.
      Rio Grande, El Paso, Tex.
                  Brownsville, Tex.
      San Joaquin R., Vernalis, Calif.
      Sacramento R., Green's Landing, Calif.
      Yakima R., Richland, Wash.
      Columbia R., Northport, Wash.
                   Wenatchee, Wash.
                   Pasco, Wash.
                   McNary Dam, Ore.
                                                           0.0005-0.002 mg/1
                                                           0.0003-0.0005 mg/1
                                                   1966

                                                   1964,66


                                                   1962
U.S.S.R.: open bodies of water
          water supply sources
                                                           0.0008-0.003 mg/1
                                                           0.0004 mg/1
              Cl   Cl

-------
     TABLE I  CCONT.) - CONCENTRATION OF ORGANIC POLLUTANTS IN WATER
     Ref   Agent
                       Source
                          Location
                                  Concentration
     261   NITROCHLOROBENZENE
             NO,
                                                 AROMATIC DERIVATIVES
                       industrial waste

                       dye chemistry
                                                           37 ug/1

                          Mississippi R., New Orleans, La. 1-2 ug/1
 Cape Girardeau,  Mo.
(Mississippi R.)
N>
in
     259
     413
TEDION
(Tetradifon)
     169   METHYLMERCURIC
          CHLORIDE
           CH3HgCl
       MERCAPTANS AND OTHER SULFUR ORGANICS

pesticide                 Niagara R.
                                                   ORGANOMETALLICS
                       acetaldehyde plant
                       acetaldehyde plant
                                  industrial waste
                                 used as seed dressing
                                                                                             0.11 ug/1    Aug.  1964
                          Minamata Bay, Japan

                          Agano R., Japan

                          Lake Erie
                          Great Lakes, Canada
                          Lakes and streams in Southern
                          and Central Sweden
                                  9-85 mg  Hg/kg/dry weight of
                                     fish 1960-1963
                                  14.4 mg/1 5km from mouth of
                                     the  river 1965
                                  found
                                  5 mg/1 in fish
                                  found

-------
TABLE II - MAMMALIAN ACUTE AND CHRONIC TOXICITY OF ORGANIC POLLUTANTS
                         FOUND IN FRESH WATER
     This table contains acute  and chronic  toxicological informa-
     tion on chemicals  found in water presented in Table I.   LD50
     in mammals form the highest proportion of the acute toxicity
     information available and  data on non-mammalian species (fish
     and birds  were  included only if toxicity information on mam-
     mals was not available or  was scant.)  Included under the LD50
     column was data available  on humans at doses where fatalities
     can occur  and  are estimates only.   These are essentially LD10Q
     data.   All doses are oral  unless otherwise indicated where
     oral information was not available. Large gaps of information
     exist for  chronic  toxicity and the greatest proportion of
     chronic toxicological data presented in this table came from
     the Russian literature.  The doses  presented for chronic
     toxicity are those which elicited an effect and where this
     was not available  the doses used are presented.  The chronic
     toxicity effects varied according to what was looked for.
     The Russian data included  changes in conditioned behavior
     and little  information  was available  on how the data was
     obtained or treated.

-------
TABLE  II - MAMMALIAN ACUTE  AND CHRONIC TOXICITY  OF  ORGANIC POLLUTANTS FOUND  IN  FRESH WATER
Agent
UNSURSTITUTED
METHANE

HALOGENATED
ALDRIN






Ref
252

252
338
124
293
451
252
449
173
252



Acute
Species
sunfish
fathead
human
rat
chick
bobwhite
quail
ringneck
pheasant
mourning
dove

Toxicity
Oral 96 hr. TLm LC50
LD50 mg/kg mg/1 mg/1
ALKANES AND ALKENES
not toxic
not toxic at 65mg/l after 2 hrs
5000 (fatal)
50
39 
-------
      TABl£  II (CONT.) -  ACUTE AND  CHRONIC  TOXICITY  OF  ORGANIC  POLLUTANTS
      Agent
                                        AcuCe Toxicity
                      Ref
             Species
              Oral
            LD50 mg/kg
96 hr. TLm
   mg/1
LC50
rag/1
                                                                                                        Chronic Toxicity
                                                                                      Ref   Species    Dose
                                                                                            Effect
ALDRIN (cont.)
BKC
                     101,174,252

                     449
                     101

                     101,449
                     338
                     431,438

                     431
fathead


goldfish

fish


D.  magna
                                  rainbow
                                  trout
449


174,252,449   bluegill
                     252
                     338
             bobwhite
             quail

             ringneck
             pheasant

             fish

             trout
            6CO
            200


            250


            450
                                       ALKANES AND ALKENES

                                        0.033

                                        0.028
                                        0.033

                                        0.028

                                        0.024
                                        0.02

                                        0.01
                                                             0.033
                                                             0.013
                           2.0

                           3.0
                                           0.14

-------
TABLE II (CONT.) - ACUTE AND CHRONIC TOXICITY OF ORGANIC  POLLUTANTS
Agent

BUG (cont.)



B-ISOMER BHC
CHLORDANE














Ref

101,449
101,442,449
101,449

252
252

338
293
49
340
451
452
173
124
252


338
Acute
Species

fathead
bluegill
goldfish
guppy
rat
human

rat







bobwhite
quail
ringneck
pheasant
fish
Toxlclty
Oral 96 hr. TLm LC50
LD50 mg/kg mg/1 mg/1
ALKANES AND ALKENES
2.3
0.079
2.3
2.17
6000
100 (fatal)

500
355
490
225-590
450-500
355-590
283
530 (dermal)

250
500
0.69
Chronic Toxicity
Ref Species Dose Effect






444 rat 1-5 mg/kg Inhibition of steroid
daily for activity
7 days

252 bird Decrease in reproduction










-------
TABLE II (CONT.) - ACUTE AND  CHRONIC TOXICITY OF ORGANIC POLLUTANTS
Agent

CHLORDANE (cont.)









DIELDRIN











Acute Toxicity
„ _ c . Oral 96 hr. TLm LCSO
Ref Specie. ^50 mg/kg M/i n8/1
ALKANES AND ALKENES
174 channelcac 0.5
101,449 fathead 0.052
252 0.052-0.069
101,252 goldfish 0.082
101,174,252 guppy 0.19
101,252,442 bluegill 0.022
449 0.054
rainbow n ...
0.022
trout
252 human 5000 (fatal)

338,340 rat 60
126,293 46
173 40
240 37-87
449 40
451 60-90
49 142 (18.6% active substance)

338 fish 0.016
252 0.005-0.042
Chronic Toxicity
Ref Species Dose Effect











444 rat purified Stimulated activity of
substance liver microsomal enzymes
4 days I.F. that metabolize estrone;
inhibited the estrone-
induced increase in
uterine wet weight and
aecreaped the amount of
trltiated estrogen found
in the uterus after an
injection of tritiated
estrone


-------
TABLE II (CONT.)  - ACUTE AND CHRONIC TOXICITY OF ORGANIC  POLLUTANTS

Ref

DIELDRIN (cont.) 174,252,442,
449
174,252

101,174,252,
449


ENDOSULFAN 124


252

366
173
EHDRIN 338
124


173
293
451
252
Acute Toxicity
- .... Oral 96 hr. TLm LC50
SP»ci" LD50 mg/kg mg/1 »g/l
ALKANES AND ALKENES
bluegill 0.0079

channel cat < 2.5

. fathead 0.016

goldfish 0.037
guppy 0.022
rat 43 (dermal)
3-6
17.8
10-12
7.3-48
Chronic Toxicity
Ref Species Dose Effect

311 human 0-0.211 mg/d. No ill effects

434 Japanese 10 mg/kg Affected reproduction
quail











67 catfish Inhibition of electron
transport enzymes and
cholinesterases
270 warmblood- 0.0003 mg/g Threshold concentration
ed animals in blood





-------
TABlf II  (CONT.) - ACUTE AND CHRONIC TOXICITY OF ORGANIC  POLLUTANTS

Ref

ENDRIN (cont.) 252







338

174,251,252,
449
174

174,251,438,
449
174,252,442,
449
174,252,449
449

Acute Toxicity
Species Oral 96 hr< TLm LC5°
P LD50 mg/kg mg/1 mg/1
ALKANES AM) ALKENES
monkey 3

rabbit 7-10

guinea pig 36 
-------
TABLE II (CONT.) - ACUTE AND  CHRONIC TOXICITY OF ORGANIC  POLLUTANTS
Agent

HEPTACHLOR




















ISODRIN





Ret

252,338,340
124


293
451 451
173 173

338 338

174,251,252

174,252

101,174,252,
449



252

252
449
173
252

Acute
Species

rat







fish

bluegill

catfish

fathead

goldfish
guppy

red-sided
shiner
rat


rabbit
chick
Toxlcity
Oral 96 hi. TLm LC50
LD50 mg/kg mg/1 rag/1
ALKANES AND ALKENES
90
100 «
162 *
250 *) (deraal>
100
90-130
40

0.056

0.019

0.175

0.094

0.23
0.25
0.107
0.096-0.11

7-42
10
7-17
5-7
2.7
Chronic Toxlcity
Ref Species Dose Effect

444 rat purified, Stimulated the activity of
I.F., 4 days liver microsomal en-
zymes that metabolize
estrone; Inhibited the
estrone-lndueed increase
in uterine wet weight
and decreased the amount
of trltlated estrogen
found in the uterus
after an injection of
tritiated estrone

54 rat >0.0025 Changes in physiological
mg/kg daily and biochemical actlvitlei
of the organism













-------
TABLE II  (CONT.)  - ACUTE AND  CHRONIC TOXICITY OF ORGANIC  POLLUTANTS
Acute
Agen t " """~— *• ~~— — ~~~— "-~~~~
Ref Species

LINDANE 338,340,351 rat
49
124



173

252 bobwhite
quail

ringneck
pheasant
mourning
dove
338 fish
101,174,252, bluegill
449
fathead

goldfish
guppy
449 rainbow
trout
Toxicity
Oral 96 hr. TLm LC50
LD50 mg/kg mg/1 mg/1
ALKANES AND ALKENES
125
107
88 
-------
TABLE  II (CONT.) - ACUTE AND  CHRONIC TOXICITY OF ORGANIC  POLLUTANTS
Agent

TOXAPHENE
























Ref

252

338
124


293
340
451
252
49
173
338
101,174,449
252
101,
101,251,252,
449
101,174,252,
449
252

252

Acute
Species

human

rat









fish
blueglll
fathead

goldfish

guppy

trout
(finger ling)
rainbow
trout
Toxicity
Oral
LD50 mg/kg

96 hr. TLm LC50
ag/1 ng/1
ALKANES AND ALKENES
5000 (fatal)

40
90 
-------
TABlf II  (CONT.) -  ACUTE  AND CHRONIC  TOXICITY OF ORGANIC POLLUTANTS
Agent

ALIPHATIC
DIETHYLAMINE





DDtETHYLAMINE


















Acute Toxiclty
_ , e.4. Oral 96 hr- TLm LC50
Ref Species LDSO mg/kg mg/1 mg/1
AMINES

252 rat 540

176 mouse 646.6
252 creek chub 85 (46 hrs)


-t
88,89 rat 698

mouse 316

guinea pig 240

rabbit 240












Chronic Toxicity
Ref Species Dose


176 rabbit 6 mg/kg/day
for 7 mos
rat 64.8 mg/kg
daily for
2 1/2 mos


89 guinea 107 mg/kg
pig for 6 wks


rabbit 160 mg/kg
for 6 wks





guinea 3.5 mg/kg
pig daily for
8 mos





Effect


Disturbance in carbohydrate
function of the liver
No appreciable cumulative
properties; decrease in
weight gain; increase In
ascorbic acid content of
the liver
Increase in blood hemo-
globin; increased act-
ivity of blood cholines-
terase
Increased urea content in
blood serum; increase in
coproporphyrin excretion
In urine; Increase In
weight coefficient of the
liver; decrease in vitamii
C in organs
Increased corproporphyrln
excretion in urine;
increase un urea content
in serum; decrease in
vitamin C content of
auprarenals; Increase in
weight coefficient of
the liver

-------
       TABU  II  (CONT.)  - ACUTE AND  CHRONIC  TOXICITY OF ORGANIC  POLLUTANTS
       Agent
                                         Acute Toxicity
                       Ref
                                   Species
              Oral
            LD50 mg/kg
96 hr.  TLm
   mg/1
LC50
•I/I
                                                                                                           Chronic Toxicity
                                                                                         Ref   Species    Dose
                                                                                                                    Effect
                                                                    AMINES
DIMETHYLAMINE  (cont.)
                                                                                        89
                                                                                               rat
ETHYLAMINE
                      252
METHYLAKINE
                      252
rat          400

mouse        530-580

creek chub
                                   creek chub
                                                               40 (48 hrs)
                            tatal  at 30
                            survived at 10 for
                            24 hrs
                                                                                        117    rabbit
                                                                                               rat
                                                                                        328    rat
                                                                                               rabbit
                                                                      0.35 mg/kg
                                                                      daily for
                                                                      8 rros
                                          0.25 mg/kg
                                          daily for
                                          6 mos
                                          2.5 mg/kg
                                          dally for
                                          6 roos
                                          0.75 mg/kg
                                          daily for
                                          9 mos

                                          0.5 mg/kg
                                          daily for
                                          i 7 mos
                                                     Retards appearance and
                                                       stabilization of the
                                                       positive reflex; prolongs
                                                       latent period; decrease
                                                       in magnitude amd percent-
                                                       age incidence of the
                                                       conditioned reflex
                                    Change in albumin/globulin
                                      coefficient
                                    Change in conditioned
                                      reflexes
                                    Change in general condition
                                      of animals; development
                                      of a lymphophenia within
                                      2 months
                                    Decrease in cholinesterase
                                      activity of blood

-------
TABLE II (CONT.) - ACUTE AND  CHRONIC TOXICITY OF ORGANIC  POLLUTANTS
Agent

AROMATIC
ANILINE




0-ANILIKE

m-ANILINE

Acute Toxicity
R.f  TLm LC5°
Ref Speci.s u>50 mg/kg mg/1 mg/1
AMINES
217 rat 750
mouse 1075
252 dog 5CO
fathead 200 (toxic level.)
goldfish 1000 " "
trout 1000 " "
269 rat 1246.1
guinea pig 2350

269 rat 700
guinea pig 450
Chronic Toxicity
Ref Speices Dose Effect

217 rz.t > O.OC5 ng/kgEffect on conditioned
daily reflexes




252 human Anemia, anorexia, loss of
weight, cretaneous lesion
and bladder trouble
253 cat Increase in level of
methaemoglobin



-------
       TABLE  II (CONT.)  -  ACUTE  AND CHRONIC TOXICITY  OF  ORGANIC  POLLUTANTS
      Agent
                                        Acute Toxlcity
                       Ref
             Special
              Oral
            LD50 mg/kg
96 hr.  TLm
   mg/1
LC50
mg/1
                                                                                                          Chronic Toxiclty
                                                                                        Ref   Species    Dose
                                                                                                                   Effect
                                                                   AMINES
NITRILES

2,6-DICHLOROBENZO-
NITRILE
131
                      417
rat         4500

rabbit      .270

guinea pig   2100

blueglll

trout
                                                                 131
                                                                        rat
                                          100 mg/kg
                                          dally

                                          200 mg/kg
                                          dally
                                                                                              Increase in liver weight
                                                                                                                    Increase in kidney weight
                                                                               22

                                                                               23
HETEROCY.CLIC

PYRIDINE
                      252,435,449   mosquito
                                   fish
                                         1300
                                         1350
                                                                 252
                                                                                       464    warm-
                                                                                              blooded
                                                                                              animals
                                                                     0.125 mg/kg Pathological effects
                                                                     daily

                                                                     0.125 and   Failed  to gain weight,
                                                                     0.25 mg/kg    change in prothrombln
                                                                     daily         time, slight histological
                                                                                   changes in the liver

-------
       TABLE  II  (CONT.) - ACUTE AND  CHRONIC TOXICITY  OF ORGANIC  POLLUTANTS
      Agent
                                       Acute Toxiclty
                      Ref
                                  Species
                           Oral
                         LDSO mg/kg
96 hr. TLm
   mg/1
LC50
mg/1
                                                                                  Chronic Toxicity
                                                                                      Ref   Species    Dose
                                                                                                                 Effect
CARBOXYLIC

ACETIC ACID
BUTYRIC ACID
CWROIC ACID
                                                               ORGANIC ACIDS
252          rat         3310

             mouse        4960

             bluegill

170          goldfish
                     252,435      mosquito
                                  fish

                     435          creek chub
252          rat         8790

88           D.  magna



88           bluegill
75

100
423 (toxic dose)


251

100-200
                                                             61 (48 hrs)
                                                             150-200  ( 48 hrs)

-------
TABLE II  (CONT.)  - ACUTE AND CHRONIC TOXICITY OF ORGANIC  POLLUTANTS
Agent

2,4-D















FENAC
FORMIC ACID

FROPIOKIC ACID

Acute Toxicity
Ref

252

252
173

252,303



252

174


174
252
173
252
88
88

B..O<.. Orml 96 hr- TLn LC5°
SP«ci«« u>50 ng/kg ag/i ng/i
ORGANIC ACIDS
human 15,000 (MLD)

rat 666
400-500

mouse 375

rabbit 800

dog 100

bluegtll 375 (46 hrs)
350 (24 hrs)

largepouth 350 ( 48 hrs)
bass 350 (24 hrs)
rat 1780-3000
dog 4CCC
bluegill 175 (24 hrs)
culex sp. >1000 (48 hrs)
larvae
Chronic Toxicity
Ref Species Dose

252 dog 20 mg/kg
daily

372 human 500g dully
for 3 wits

378 rat 50 mg/kg
daily for
12 moe



378 aquatic high cone.
fauna applied for
mosquito
control





Effect

Toxic


No unfavorable effects


Slight decrease in blood
catalase; slight decrease
in liver glycogen
concentration; no path-
ological changes

No adverse effects









-------
        TABl£  II (CONT.) -  ACUTE AND  CHRONIC  TOXICITY  OF  ORGANIC  POLLUTANTS
      Agent
                      Ref
                                       Acute Toxicity
                                  Species
                           Oral
                         LD50 ng/kg
                           96 hr. Tim
                             mg/1
                               LCSO
                               mg/1
                                                                                  Chronic Toxicity
Ref   Species    Dose
Effect
SILVEX
2,4,5-T
VALERIC ACID
252
173
252


174




252

173




88
                                                                ORGANIC ACIDS
                                  rat
                                  laboratory
                                  animals

                                  emerald
                                  shiner

                                  chlnook
                                  salmon
human

rat




D. magna
            650
            650-1070


            500-2000
                           7 (72 hrs)


                           136  (24 hrs)
54,000  (toxic)

300
300-800
               45 (48 hrs)

-------
TABl£  II  (CONT.)  - ACUTE AND CHRONIC TOXICITY OF ORGANIC  POLLUTANTS
Agent

SULFONICS
ABS























Acute Toxiclty
Ref


81
397
260
153

397





405
251
252,317
174,251
405
252
387
405






S ecle* Oral 96 hr> njn LC5°
LD50 mg/kg mg/1 mg/1
ORGANIC ACIDS

rat 2200
1400-2500
520
300

mouse 1400-2800

hamster 1130

rabbit 1730

bluegill 8.2
4.2-4.4
5.6
fathead 3.5-4.5
U^
.3
4.6
fathead eggs 12.8
emerald
shiner '

bluntnose . .
minnow
stoneroller 8.9
silver jaw
minnow ' • '
Chronic Toxiclty
Ref Species Dose


266 bluesill 5-6 mg/1

127 rat 230 mg/kg
daily for
45 days





366 trout 0.001 mg/1

10.0 mg/1
265 D. magna small
amounts

323 guinea 2Z in water
pig for 6 mos

pig 0.2Z in
food for
79 days



Effect


Histological changes

Increase in weight of
spleen, liver, and
adrenal gland, Increase
in vitamin C content of
adrenal gland; increase
in cholesterol level of
blood

Avoided water with this
concentration
Caused confusion; unable
to distinguish
Decreased respiration;
decreased metabolism;
decreased reproduction
No alarming symptoms; no
hlstological changes

No effect; 99. 5Z eliminated
within 8 days




-------
        TABLE  II  (CONT.)  -  ACUTE  AND CHRONIC  TOXICITY OF  ORGANIC  POLLUTANTS
      Agent
                      Ref
                                       Acute Toxlcity
Sped**
  Oral
LD50 mg/kg
96 hr. TLo
   mg/1
LC50
mg/1
                                                                                                      Chronic Toxicity
                                                                                      Ref   Species   Dose
                                                                               Effect
ABS (  cont.)
tp- ABS
ABS (  linear)
                     405
                     397
                     397
                     260

                     251
                     383

                     387
rosefln
shiner

common
shiner

carp

black
bul1!
                                  rat
                                  rat
bluegill
flngerllng

fathead

fathead
(eggs)
            520-1220
            650-1260
            650
                                                                  ORGANIC ACIDS
                                                             9.5


                                                             17.0


                                                             18.0


                                                             22.0
               0.6-3.0

               3.5

               3.4 (24 hrs)

-------
TABl£ II (CONT.) - ACUTE AND  CHRONIC TOXICITY OF ORGANIC  POLLUTANTS
Agent

RONNELL











DEF




Acute Toxicity
c , Oral 96 hr. Tim LC50
Ref Speciee ^^ ^^ ^ ^
PHOSPHATE ESTERS
124 rat 1250 5000 (denral)
340 1700
173 1000-3000
252 guinea pig 3240
rabbit 640
mouse 2140
dog 500
duck 5000
chicken 5000
turkey 500
124 rat 233 *
150 »
360 rf)
168 ?) '
173 325
Chronic Toxicity
Ref Species Dose Effect



















-------
TABLE II (CONT.)  - ACUTE AND CHRONIC TOXICITY OF ORGANIC  POLLUTANTS
Agent

PYRENE
o-CRESOL



p-CRESOL


CRBSOL

Acute Toxlcicy
R«f SD.C!.. Oral 96 hr> "* LC5°
Ref Spec!.. ujso «g/kg «,/! .g/l
UNSUBSTITUTED AROMATICS
333 mouse 9400
PHENOLS AND QUINONES
252 rat 1350
catfish 11.2
174 blueglll 55-65 (lethal in 1 hr)
perch 10-20 (lethal in 1 hr)
252 rat 1800
174 blueglll 80-90 (lethal in 1 hr)
perch 10-20 (lethal in 1 hr)
435 mosquito ,„
449 fish *•
449 blueglll 10.0-13.6
Chronic Toxlcity
Ref Species Dose Effect












-------
TABLE II (CONT.) - ACUTE AND  CHRONIC TOXICITY OF ORGANIC  POLLUTANTS

Ref

PENTACHLOROPHENOL 124
115
252
115
PENTACHLOROPHENATE, Na 252
115
115
252

PHENOL 252
449
Acute Toxicity
Oral 96 hr. TLa LC50
Specie* LDSO mg/kg mg/1 mg/1
PHENOLS ANQUINONEj^
rat 146 
-------
TABLE II (CONT.) - ACUTE AND  CHRONIC TOXICITY OF ORGANIC  POLLUTANTS
Agent

PHENOL ( cont,)






PYROCATECHOL

HALOGENATED
DDD









Acute Toxiclty
P f *,«c<.. Oral 96 hr' TtM LC5°
Ref Specl.8 W5Q ^^ ^^ mg/1
PHENOLS AND QUINONES
252,435,449 mosquito ,
fish 56

252 catfish 16.7



252 rat 3890
AROMATIC DERIVATIVES

124 rat >4000
252 3400
173 400-3400

252 bluegill 0.03
449 0.056
174,252 channel cat <2.6



Chronic Toxicity
Ref Species Dose Effect

373 fish 3-5 mg/1 Change in behavior; foam-
>10 mg/1 Ing secretion from skin;
> 16 mg/1 paralyzed and sank;
335 fish damaged nervous system.
epithelial tissue,
intestines, reproductive
system and blood



444 rat Affected steroid metabolism

330 human Significant increase of the
mean DDD concentration
was found in cases of
hypertension
329 h,.n
-------
TABLE  II (CONT.) - ACUTE AND  CHRONIC TOXICITY OF ORGANIC  POLLUTANTS
Agent

DDD (cont.)

DDE















DDT






Acute Toxicity
„ . Oral 96 hr. ILm LC50
Ref Species jjjjo Bg/kg ^ Bg/1
AROMATIC DERIVATIVES


124 rat 880 
-------
TABlf I! (CONT.) - ACUTE AND  CHRONIC TOXICITY OF ORGANIC  POLLUTANTS
Agent

DDT (cent.)
























Acute Toxicity
Ref

279
252

252

338

101,174.252
449
101,174,252
383
174,252,449
251

101,174,252

174

252
449

18,416




, Oral
SPecie8 LD50 mg/kg

mouse 580
150

chicken 1300

fish

bluegill

fathead

goldfish

guppy

channel cat

rainbow
trout

goldfish




96 hr. TLm LC50
mg/1 tug /I
AROMATIC DERIVATIVES





0.034

0.016
0.007
fl.032
0.0155
0.027
0.028

0.043

>1.0

0.0237-0.074
Onno
• UUO
1.0 (loss of balance)




Chronic Toxicity
Ref Species Dose Effect

279
and succinic dehydrases
in hepatic tissue;
change in conditioned
reflexes; histological
changes in liver,
kidneys, myocardium,
suprarenals and brain
Affects steroid metabolism

302 rat 200 mg/kg Increase in ringtail
daily
May have effect on
reproduction in the case
of marginal fertility
443 Increase in uterine weight

330 human Significant elevated conc-
entrations in brain and
adipose tissue in cases
of hypertension

311 warmblood- 3.5 & 35 No ill effects up to
ed animals mg/day for 27 mos after study
21 mos
298 poultry 20 mg/kg No effect on reproduction
for 10 wks
1000 mg/kg Reduced egg production and
for 10 wks hatchability

-------
         TABLE  II  (CONT.) -  ACUTE AND  CHRONIC TOXICITY  OF  ORGANIC  POLLUTANTS
      Agent
                                        Acute Toxlclty
                       Ref
                                   Species
  Oral
LD50 mg/kg
96 hr.  TLm        LC50
   mg/1          mg/1
                                                           Chronic Toxicity
Ref   Species    Dose
                                                                                                                    Effect
                                                             AROMATIC DERIVATIVES
DDT (cont.)
NITROCHLOROBENZENE
                      58
                                   rabbit
                                               520
                                        152    mallard    25 mg/1
                                                      Significant thinning of
                                                       shells; reduced duckling
                                                       survival by 355!
                                                                                       324    fish       6.2 mg/1    No physiological stress
                                                                                                         (whole body
                                                                                                          cone.)

                                                                                       30     Japanese   100 ppm for Decrease in eggshell Ca
                                                                                              quail      45 days

                                                                                       402    mouse      0.4-0.7     Leucocytosis
                                                                                                         mg/kg for
                                                                                                         5 generations
                                        58     rabbit     0.5 mg/kg   Slight delay  in the decreaa
                                                          at least      of the agglutination
                                                          4 mos         titer; change in
                                                                       phagocytic  activity of
                                                                       leucocytes

                                        144    rat        0.025 mg/kg Change in conditioned
                                                          daily for     reflexes
                                                          8-9 mos

-------
          TABlf II  (CONT.)  - ACUTE AND  CHRONIC  TOXICITY  OF  ORGANIC  POLLUTANTS
        Agent
                                          Acute Toxicity
                        Ref
                                    Species
  Oral
LD50 mg/kg
96 hr.  TLm
   mg/1
LC50
mg/1
                                                            Chronic Toxicity
                                                                                          Ref   Species    Dose
Effect
                                                                  ORGANOMETALICS
METHYLMERCURIC CHLORIDE
                       169
                                    cat
                                    rat
10-50 (as  Hg/kg) LD
20 ( most  ofted LD)

20 (as Hg/lOOg) LD
                         169   cat       1 mg/kg/day  Clumsiness in walking,
                                                        unsteady movements,
                                                        ataxlc gait, dullness,
                                                        tremor, blindness, paro-
                                                        xysmal fits (several week:
                                                        after administration)

                               rat       1-2 mg/100g/  Body weight decrease.
                                        day  CH.HgCl    action slow, occasionally
                                        and (CH.Hg).S    clonic cramps; sympton
                                                        same as cats

                         1,169, human     fish from    Numbness of limbs, constr-
                         349             Minamata Bay    ictlon of visual field,
                                                        ataxia, impairment of
                                                        hearing and speech; ( in
                                                        severe cases unconscious-
                                                        ness, marked violent
                                                        agitation and death)

                         1,412, human     fish from    22 cases, 5 deaths;Hg found
                         413             Agano R.       In hair of patients

-------
TABLE III - MAMMALIAN ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC

                      POLLUTANTS OF FRESH WATER
     This table contains acute and chronic toxicity of potential


     organic pollutants in fresh water.  These chemicals are sus-


     pected to be in water because of their use for industrial,
                                   /

     agricultural or domestic purposes or because they are known


     to be involved in manufacturing processes the waste products


     of which are likely to be  discharged  into fresh water.  This


     listing is probably incomplete.  As with Table II, there are


     gaps in our knowledge of both acute and chronic toxicity in-


     formation.

-------
TABLE  III - MAMMALIAN ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS OF FRESH WATER
Agent

UNSUBSTITUTED
AMYLENE
(CH,),C-CHCH,
32 3
BUTYLENE
CH CH CH»CH
32 2
CYCLOHEXANE
C H
°6H12
O

CYCLOHEXENE
C.H,_
6 10

r^.
\J






ETHYLENE
2 2


Source


tar and gas wastes


effluent from
production of
styrene rubber
found in petroleum,
used for solvents,
for lacquers & resins
or for paint remover

petroleum, used as
solvent for lacquers
& resins or for
paint remover








manufacture of plas-
tics, alcohol, mustard
gas, ethylene oxide,
& other organics


Acute Toxicity
Ref Species LD50 mg/kg 96 hr TU. LC50 a
mg/1
ALKANES AND ALKENES

252 sunfish lethal in
174 1 hr at
655-693
252


354 mouse 4700

435 mosquito 15,000
fish

355 mouse 2300











252 sunfish lethal in
1 hr at
22-25 mg/1


Chronic Toxicity
Ref Species Dose Effect








354 rat 400 mg/kg Decrease in catalase activity;
for 14-40 decrease in cholinesterase
days activity
0.05 mg/kg Change in conditioned reflexes
daily for
4 mos
355 white 500-4000 Decrease in weight
mouse mg/kg

white 100 mg/kg Decrease in catalase and
rat during 14 cholinesterase activity
days
white 400 mg/kg Decrease in capacity of liver
rat during 14 for synthesis of hippuric
days acid
rabbit 0.05-0.005 Decrease in catalase and
mg/kg for 6 cholinesterase activity
mos period
LD50 - dose at which 50% of animals died.
96 hr TLm - concentration at which 50% of fish died in 96
hrs (or other time indicated) .
LC50 - concentration at which 50% of fish died in 24 hrs.

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

ETHYLENE (Cont'd)


HEPTANE
CH3(CH2)5CH3
ISOBUTYLENE
CH \
3
ISOFRENE
CH-
| j
C^-C-CH-C^




PROPYLENE
CH3CH»CH2
HALOGENATED
ALLYL CHLORIDE
CH,-CHCH,C1
2 2
Source

effluent from pro-
duction of synthetic
ethyl alcohol
gasoline or other
petroleum wastes
effluent from pro-
duction of styrene
rubber
synthetic rubber
industry






effluent from pro-
duction of synthetic
ethyl alcohol




Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLm LC50 mg/1
mg/1
ALKANES AND ALKENES



252 mosquito 4924
435 fish














179 less toxic
than the
alcohol
Chronic Toxicity
Ref Species Dose Effect






^•3 8 mg/kg Behavior changes & change in
general condition 15-20 min
after ingest ion
194 warm 5 mg/1 No effect
blooded
animals
191 rabbit 2.5 mg/kg Change in catalase activity
daily for
2 mos
rat 0.25 mg/kg Change in conditioned reflexes
daily







-------
TABL£ III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF  POTENTIAL ORGANIC  POLLUTANTS
Agent

BUTANE, POLYCHLORO.
C.C1 H.-
•t X JLU^X

CARBON TETRACHLORIDE
rn
cci4



















Source

pesticide
intermediate in hexa-
chlorobutadiene pro-
duction
effluent from: manu-
facture of freons &
tetra-ch lor-alkanes ,
solvent in machine
building, rubber &
chemlcopharmaceutlca 1
industries



















Acute Toxicity
Ref Species LD50 mg/kg 96 hr ™" LC50 mg/1
ALKANES AND ALKENES
274 white mouse 2000-2500
guinea pig 940-1400


219 albino rat 6139cf
5650?
340 rat 5730-9770
219 white mouse 9123
guinea pig 5760
rabbit 5760



















Chronic Toxicity
Ref Species Dose Effect





219 albino 1/10 LD50 Considerable cumulative
rat for 1 mo. properties
dally
15 mg/kg Reduced content of erythrocytes ,
leukocytes, & hemoglobin;
Increase in SH groups in blood
serum followed by decrease;
increased actlvl1"" of glutamlc
oxalacetlc glutamlc-
pyruvlc transminases & lactic
dehydrogenase in blood serum;
prolonged prothrombin time
increased concentration of
urea in blood serum & of
coproporphyrln In the urine;
disturbance of renal function;
increase of vitamin C in liver
& kidneys
1.5 mg/kg Same effects as above; distur-
bance in interrelationships
between the main cortical
processes of inhibition and
stimulation
252 human 5 mg/1 Death
skin Dermatitis
(repeated
contact)

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

CHLOROCYCLOHEXAHE
o
CHLOROFORM
CHC13
















DBCP
(NElttGON)
H H H
H-^-C-C-H
BrfcrCl
Source

effluent from indus-
try producing capro-
lactara
solvent for fats &
varnishes manufacture
of alkalies & rayon
















pesticide



Acute Toxicity
Ref Species LD50 rag/kg 96 hr TUn LC50 mg/i
mg/1
ALKANES AND ALKENES


263 white mouse 1750
white rat 1875
guinea pig 1750
















174 bluegill 20 (48 hr)
largemouth 20 (48 hr)
baas

Chronic Toxicity
Ref Speclea Dose Effect

300 experi- 0.25-25 Disturbed conditioned reflex
mental rag/1 for
animals 6 mos
620 guinea 0.4 mg/kg Increase In vitamin C in
pig adrenals
35 mg/kg Decrease In blood catalase; i
decrease in phagocytic capa-
city of leukocytes; structural
lesions in liver, heart muscle
& stomach wall; fatty infil-
tration, necrobiosia, &
cirrhosis of liver parenchyma,
lipoid degeneration & proli-
feration of interstitial cells
in myocardium, and acute edema
of the submucous & muscular
layers of the stomach
albino 0.4 mg/kg No effect
rat 125 mg/kg Decrease in conditioned reflex;
decrease in chollnergic acti-
vity; hlstological changes
60 12.5 mg/kg Affects conditioned reflexes
by fourth month





-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

DICHLOB.QBUTANE
CH CH CH CHC1










DICHLOROCYCLOHEXANE

o
Cl



DICHLOROETHANE
C H Cl
(-2B4L12
Source

effluent from plants
producing synthetic
rubber from acetylene









effluent from plants
manufacturing capro-
lactam




Industrial organic
solvent; manufacture
of tobacco extract
Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLm LC50 „-/!
mg/1
ALKANES AND ALKENES
175 rabbit 5 mg/1 for 2 hr caused degenera-
cat tive changes in all animals In
mouse bronchial epithelium
3 mg/1 for 2 hr caused purulent
and necrotic pneumonia and pre-
bronchitis, swelling of kidney
canaliculll and irritation of
hemopoietic organs






207 white mouse 480






252 rat 770


Chronic Toxicity
Ref Species Dose Effect

175 dog Apathy; disturbed coordination;
symptoms of paresis & paraly-
sis; increased rate of respi-
ration, cough, salivation,
diarrhea, and progressive
loss of weight
rabbit 0.005-10 0.005-0.1 mg/kg: no effect
dfily for l and 10 mg/k8: welght loss'
, increase in blood sugar, in-
m crease in leukocyte number,
increase in pyruvic acid
content of blood
10 mg/kg: liver tissue hyper-
emia; change In liver, kid-
neys, brain, lungs & testicles
207 white 12.5 mg/kg Increase In reticulocyte number;
rat for 6 mos decrease in normob lasts; other
blood composition changes;
wrinkling of nerve cells of
brain; inflammation of liver;
tissue edema in all organs;
spleen capsule trabeculi and
vascular walls of all organs
indurated




-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

1,2-DlCHLOROHEXA-
FLUORO-1-CYCLOHEXENE
F
F-T — ^~f
F A //Vl
Ft — ^
1,2-DICHLOROHEXA-
FLUORO-CYCLOPENTENE- 1
Cl
J\
C1~V /^
\ / F
F "> < F
F F










DICHLOROMETHANE
CH Cl




Source







synthesis of fluorine-
containing rubbers &
other polymers














production of plas-
tics & synthetic
rubber used in refri-
gerators


Acute Toxic! ty
Ref Species LD50 mg/kg 96 hr TLm LC50 mg/1
mg/1
ALKANES AND ALKENES






381 mouse 276
















414 mouse 5600





Chronic Toxicity
Ref Species Dose Effect

380 rat & 0.02 mg/kg No effect on carbohydrate meta-
rabbit daily holism, SH group, or pyruvic
acid blood concentrations, or
conditioned reflexes; higher
doses did produce morphologi-
cal changes
381 rat 28-30 mg/kg Decrease in 0, consumption
daily - 40
days
rabbit 28-30 mg/kg Inhibition of catalase activity;
daily - 90 decrease in SH groups & total
days protein; increase in blood
pyruvic acid; increase in
hemoglobin, RBC & WBC; de-
crease in monocyte & leukocyte
counts; protein dystrophy in
liver; disappearance of trans-
verse striae in cardiac muscle
fibers
rat 8.2 mg/kg Decrease in 02 consumption;
daily - decrease in conditioned re-
185 days flexes; histo logical changes
in kidney, liver & heart cells
414 rat 0.4 mg/kg Disturbance in regulatory
daily - vegetative system
6 mos
guinea 0.4 mg/kg Increase ascorbic acid content
pig daily - of adrenals
5 mos

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent
--
ETHYLENE DIBROMIDE
(BROMOFUME, EDB)
BrCHjCHjBr

ETHYLENE DICHLORIDE
CICHjCHjCl
Source

fumigant



fumigant

FREON 253
(TRIFLUOROCHLOROPROPANE)
C.H.F.Cl
343
HEXACHLOROBUTADIENE
cci2-cci-cci-cci2




HEXACHLOROCYCLO-
FENTADIENF.
ci xci

C1~"C ffCi
/-— \
Cl Cl



pesticide





manufacture of heat-
resistant & shock-
proof plastics






Acute Toxiclty
Ref Species LD50 mg/kg 96 hr^TLm LC50 ^
ALKANES AND ALKENES
340 rat 108-170
174 blueglll 18 (48 hr)
largemouth
bass IS (48 hr)
340 rat 670-890

360 white mouse 62



274 white rat 350
white mouse 87
guinea pig 90



284 white mouse 600






Chronic Toxlclty
Ref Species Dose Effect







360 rabbit 5, 0.005, Weight gain; decrease In glyco-
& rat 0.0005 genlc ability of liver; In-
mg/kg crease in blood pyruvic acid;
daily for conditioned reflexes affected
7 mos at higher doses
274, guinea 2 rag/kg Depressed phagocytic activity;
275 pig daily increase in vitamin C content
of organs; affected condi-
tioned reflexes
275 guinea 2 mg/kg Decrease In serum SH groups;
pig daily histopathological changes in
some organs
284 white 0.002 mg/kg Lymphocytes Is
rat dally - 6
mos

0.0002- No changes in peripheral blood
0.00002 cells; ascorbic acid content,
mg/kg the suprarenals, conditioned
daily - reflexes, or histological
6 mos structure of organs

-------
TABLE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF  POTENTIAL ORGANIC  POLLUTANTS
Agent

HEXACHLOROETHANE
ci3ccci3

REPOSE
	 Cl>0
TI I*" y
bV[ J ci
C / 1 ^
dr"v, \i
Cl C1
HIRKX
Cl C1
d^__l»--TCl
raV-l— rCl
ClT^I Iqj
or*2000 (dermal)
340 95
173 114-140
40 red-ear 0.029-0.14
sunfish (variation in
temperature)

124 rat 740cT
6009
340 300-600
124 >2,000 (dermal)
173 600-740
213 rat 450
mouse 360
340, rat 200-500
449 bluegill 12 .
rainbow 15
trout
415 mouse 740


Chronic Toxicity
Ref Species Dose Effect

US rabbit 0.05 mg/kg No significant effects
daily














2x3 rabbit 10 mg/1 as Change in sugar curve
drinking H20
for > 9 wks




415 rabbit 0.25 mg/kg No significant changes
daily
37 mg/kg Change in blood sugar; patho-
daily logical changes in liver
and heart

-------
TABl£ III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF  POTENTIAL ORGANIC  POLLUTANTS
Agent

TETRACHLOROETHYLENE
•
Cl-C^CClj
TETRACHLOROHEPTANE
C12CH(CH2)5CHC12





TEIRACHLORONONANE
C12CH(CH2)?CHC12



TETRACHLOROPENTANE
corn ru PH rnn
22222




TETRACHLOROPROPANE

CljjCHSHjCHCljj




Source

industrial compound


use in future for
synthesis of poly-
amide fibers as emul-
sifiera, solvents,
lacquers & heat
carriers, etc.


use in future for
synthesis of poly-
amide fibers as emul-
siflers, solvents,
lacquers & heat
carriers, etc.
n






ii






Acute Toxicity
Ref Species LD50 mg/kg 96 £r *Lo LC50 mg/1
ALKANES AMD ALKENES
382 rat 8.00 (ml/kg
undiluted)

359 laboratory 475
animals





359 laboratory 920
animals



359 laboratory 430
animals





359 laboratory 600
animals





Chronic Toxicity
Ref Species Dose Effect




359 labora- 0.03 mg/1 Change in CNS; change In 02 con-
tory 4-6 mos sumption; leukocytes is; thick-
animals daily in- ening of lung septi; moderate
halation protein dystrophy; swelling
of retlculo endothelium
rat 150 mg/kg Increase in blood leukocytes;
daily for no cumulative properties
3 mos
359 labora- 0.03 mg/1 Change in CNS; change in 02 con-
tory 4-6 mos sumption; leukocytosls; thick-
animals daily in- enlng of lung septi; moderate
halation protein dystrophy; swelling
of retlculo endothelium; no
cumulative properties
359 labora- 2.1 mg/1 Decrease in weight; decrease in
tory 2 mos. - 02 consumption; increased size
animals inhala- & weight of liver; leukocy-
tion tosls
rat 150 mg/kg Increase in blood leukocytes;
daily for no cumulative properties
3 mos
359 laboratory 2.1 mg/1 Decrease in weight; decrease in
animals 2 mos - 0. consumption; Increased sizi
inhala- & weight of liver; leukocy-
tion tosls
rat 150 mg/kg Increase in blood leukocytes;
daily for no cumulative properties
3 mos

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

TETRACHLOROUNDECANE

C1,CH(CH ) CHC1,
2 29 i.


TRICHLOROETHYLENE
C1CH-CC12
NITRO COMPOUNDS
CHLORONITROSOCYCLO-
HEXANE


Cl
o




NITROCYCLOHEXANE
NO
6 11 2
NITROETHANE

CH3CH2N02

Source







used in dry cleaning;
manufacture of chemi-
cals & Pharmaceuticals

effluent from plants
manufacturing capro-
lactam














Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLm LC50 mg/1
mg/1
ALKANES AND ALKENES
359 laboratory 4300
animals




252 dog 5860
264 mouse 5900

207 white rat 384-450












393 rat 1100

mouse 860

Chronic Toxicity
Ref Species Dose Effect

359 laboratory 0.03 mg/1 Change in CNS; change in 02 con-
animals 4-6 mos sumption; leukocytosis; thick-
daily in- ening of lung septi; moderate
halation protein dystrophy; swelling
of reticulo endothelium; no
cumulative properties
264 test 300 mg/kg Decrease in phagocytic index;
animals daily for no significant changes
2 mos

207 rat 1 & 10 Increase in blood reticulocytes ;
mg/kg increase in myeloerythroid
proportion in bone marrow;
decrease in erythropoietlc
cells; increase in weight of
liver & spleen; degenerative
necrobiotic changes
12.5 mg/kg All of above plus dystrophic
changes
0.1 mg/kg Slight effect on functional
state of organism
352 rat 1.5 mg/kg Morphological changes in kidney,
daily for liver, & nervous system
6 mos
393 rat 0.05 mg/kg Did not affect conditioned re-
daily for flexes, thiol cholinesterase,
6 mos or residual N concentration
in blood, or tissue morphology

-------
TABLE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

NITROMETHANE
CH3N02


ALLYL ALCOHOL
CH2 - CHOUGH
AMYL ALCOHOL
CH-(CH ) OH
^} 24


BUTYL ALCOHOL

3 23"

1 .4-BUTANEDIOL
CH2-(CH2)2CH2
1 '






Source







chemical wastes &
some distilling wastes



wastes from paint,
varnish & chemical
industries

manufacture of poly-
urethanes as well as
divinyl for manufac-
ture of synthetic
rubber; intermediate
product of synthesis
of the blood substi-
tute polyvinyl-pyrro-
lidone; other indus-
trial & agricultural
effluents
Acute Toxtcity
Ref Species LD50 mg/kg 96 hr ™* LC50 mg/1
mg/1
ALKANES AND ALKENES
393 rat 900
mouse 950

ALCOHOLS
77 rat 64

286 human two persons drank a mixture of butyl
& amyl alcohol - state of narcosis
449 goldfish 10
(survival time*
94 hr—o, )
286 human two persons drank a mixture of butyl
& amyl alcohol - state of narcosis
252 rat 4360
77 2750
197 white rat 2062
white mouse 1525
guinea pig 1200
rabbit 2531





Chronic Toxicity
Ref Species Dose Effect

393 rat 0.05 mg/kg Did not affect conditioned re-
daily for flexes, thiol cholinesterase,
6 mos or residual N concentration in
blood, or tissue morphology








286 cat & 1.85% Reduced activity of pancreatic
dog juice, pepsin, & trypsin


.197 rat 30 mg/kg Change in conditioned reflexes;
6 mos decrease In cholinesterase
study activity; decrease in liver
glycogen; decrease in SH
groups in grey matter of brain
& in whole blood; decrease in
vitamin C in organs; increase
in activity of blood trans -
aminases ; reduced content of
nissl bodies & growth of glial
elements in cerebral tiss".e

-------
TABIE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF  POTENTIAL ORGANIC  POLLUTANTS
Agent

1,4-BUTYNEDIOL
CHjOHC = CCH2OH








CYCLOHEXANOL


o-


DICHLOROHYDRIN
CHjClCHOHCHjCl
PIETHYLENEGLYCOL
0(CH2CH2OH)2





Source

Intermediate product
in synthesis of the
blood substitute poly-
vinyl pyrrolidone
(PVP) ; other indus-
trial & agricultural
effluents





effluent from pro-
duction of capro-
lactam





effluent from textile,
pharmaceutical, per-
fumery, & tobacco
industries; effluent
from manufacture of
synthetic resins,
fabrics, plastics, &
explosives





Acute Toxiclty
Ref Species LD50 mg/kg 96 hr TLm LC50 mg/1
ng/1
ALCOHOLS
197 white rat 104.75
white mouse 104.50
guinea pig 130.00
rabbit 150.00






353 mouse 1240





210 mouse 93

313 rat 15,650
77 20,760
314 mouse 13,300
guinea pig 14,000
rabbit 2,688
435, mosquito
449 fish 32000




Chronic Toxicity
Ref Species Dose Effect

197 rat 2 mg/kg Change in conditioned reflexes;
6 mos decrease in cholinesterase
study activity; decrease in liver
glycogen; decrease in SH
groups in grey matter of brainj
& in whole blood; decrease in
vitamin C in organs; increase
in activity of blood serum
transaminases ; reduced cont-
ent of nissl bodies & growth
of gllal elements in cerebral
tissue
353 rabbit 0.2, 2.0 Change in blood sugar levels;
& 20.0 decrease in blood catalase;
mg/kg pathological changes in kid-
daily for neys & liver at 2.0 and 20.0
6 mos mg/kg
rat 0.02 & Significant effect on condi-
2.0 mg/kg tioned reflexes


314 rabbit 0.5 mg/kg Affected kidney & liver function
daily
rabbit 0.5 mg/kg Increase In urea & indican in
daily blood serum; decrease in indi-
can in urine; shortened pro-
thrombln time; inhibited ex-
cretory hepatic function
rabbit 0.05 mg/kg No effect
daily
albino 0.05 mg/kg No effect on conditioned
rat daily reflexes
i

-------
TABLE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF  POTENTIAL ORGANIC  POLLUTANTS
Agent

DIMETHYLPHENYL-
CARBINOL
CH,

ETHYL ALCOHOL

32



ETHYLEKE GLYCOL
HOCH.CH.OH
2 2








ETHYL HEXANEDIOL
(RUTGERS 612)
HEPTYL ALCOHOL

CHj ICH2 ) jCHjOH

Source

effluent from pro-
duction of phenol &
acetone

used in manufacture of
organic substances,
perfumes, flavors, &
drugs; used for
beverages, fuel, paint
and varnishes











pesticide i repellent





Acute Toxlcity
Ref Species LD50 mg/kg 96 hr TLm LC50 mg/1
ALCOHOLS
153 rat 2540
mouse 1650

252 stickle- 40,000
back caused intoxication




313 rat 13,000
77 8,540

313 mouse 8,050
guinea pig 11,150
rabbit 5,017





340 rat 2600





Chronic Toxlcity
Ref Species Dose Effect

153 rabbit 2.5 mg/kg Increase in chollnesterase
daily activity; albuminuria; path-
ological changes in kidneys







313, rabbit 0.5 mg/kg Affected kidney & liver function
314 daily
Increase in urea & indican in
blood serum ;decr ease in indicai
in urine; shortened pro-
thrombln time; inhibited ex-
cretory hepatic function
rat 5 mg/kg Functional changes in higher
dally nervous activity
465 0.5 mg/kg No effect
daily for
4 1/2 mos


256 warm- 0.0025 Threshold causing slight
blooded mg/kg changes in conditioned re-
animals flexes and carbohydrate
metabolism

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

HEXYL ALCOHOL
CH3(CH2)5OH
ISOBUTYL ALCOHOL
(CH3)2CHCH2OH
METHYL ALCOHOL
CHjOH
MONOCHLOROHYDRIN
C1CH,CH2OH
NONYL ALCOHOL
CH3(CH2}8°H
OLEYL ALCOHOL EO
CH3(CH2)?CH-CH(CH2)7Cl
PINE OIL
(CYCLIC TERPENE
ALCOHOLS)
PROPYL ALCOHOL

Source



industrial
used in chemical syn-
thesis, as a fuel, as
a solvent & in com-
mercial manufacture
of many products

surfactant
flotoreagents efflu-
ent from non-ferrous
ore concentrating
plants
industrial solvent
i
Acute Toxlcity
Ref Species LD50 rag/kg 96 hr ,TLm LC50 mg/1
mg/1 *
ALCOHOLS
252 rat A.I

286 human intoxication can occur
in cases ingesting im-
pure vodka
252 trout 8100 mg/1
had no harmful
effects in 24 hr
210 mouse 135
77, rat 2700-25800
397
^33 slight toxic properties
when introduced orally
252 rat 3300

Chronic Toxlcity
Ref Species Dose Effect



286 dog & 1.85% Reduced activity of pancreatic
cat cone. juice
252 human small amounts lead to blindness;
10 ml has caused death
256 warm 0.005 Threshold - caused slight
blooded mg/kg changes in conditioned re-
animals flexes and carbohydrate
metabolism





-------
TABl£ III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

STREPTOMYCIN
C21H39N7°12
TERPINEOL
/ 	 v OH
// \ / PtI
CH3 -4f \\ CH3
TETRAHYDROFURFURYL
ALCOHOL
/°VCH2OH





Source

effluent from manu-
facture of strepto-
mycin
flotoreagent efflu-
ent from non-ferrous
ore concentrating
plants
Industrial effluent





Acute Toxiclty
Ref Species LD50 mg/kg 96 h* ' *Ln LC50 mg/1
ALCOHOLS
262 mouse 75
233 slight toxic properties
when introduced orally
322 albino rat 2500
white mouse 2300
guinea pig 3000





Chronic Toxicity
Ref Species Dote Effect



321 rat, 10 mg/kg Affects conditioned reflexes
mouse, dally for
rabbit 4 mos
rat, 20 mg/kg Affects chollnesterase actl-
mouse, daily for vlties, prothrombln times,
rabbit 4 mos liver glycogen concentra-
tions, and rates of Immuni-
zation
320 labora- >5 ml/1 in Pathological changes
tory drinking
animals water
322 rabbit, 20 mg/kg Weight lag; 567. decrease in
mouse, dally chollnesterase activity after
rat 2 mos.; 40-70% Increase in
prothrombln time after 2 mos.
rabbit, 20 mg/kg Increase in liver glycogen
mouse, daily level; leukocytes is ; rise in
rat oxygen consumption; hepatic
lesions
rat 10 mg/kg Decrease in conditioned reflexet
daily
(long
term)


-------
TABLE  Ml  (CONT.) -  ACUTE  AND  CHRONIC  TOXICITY OF POTENTIAL  ORGANIC  POLLUTANTS
        Agent
                            Source
                                                               Acute Toxlcity
                                            Ref   Species
                                                             LD50 mg/kg  96 hr,TLm   LC50 mg/1
                                                                           ng/1
                                                                                                                     Chronic Toxicity
                                                                                                Ref    Species    Dose
                                                                                                                             Effect
4-(g-TOLYL)-l-
PENTANOL  CH.
bleached kraft pulp
mill waste
     (_y-
-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

DI1SOPROPYLAMINE
CH3 N /CHj
CB3/ "^ \CH3


2-ETHYLBUTYLAMINE
ClUCH-
ETHYLENEDIAMINE
NH2CH,,CH2NH2
HEXAMETHYLENE-
DIAMINE
. .
2 * <>'6 2







HEXAMETHYLENE
DIAMINE ADIPATE
NH,(CH ) NH
I 262
H-
HOOC (CH,)4COOH

Source

effluent from pro-
duction of chemical
poisons







production of nylon










raw product in pro-
duction of nylon





Acute Toxic! ty
Ref Species LD50 mg/kg »6 £r.TLn LC50 ng/1
AMINES
252 rat 770
122 550
122 mouse 690


77, rat 390
252
77, rat 1160
252











41 white mouse 700






Chronic Toxlclty
Ref Species Dose Effect

122, warm 0.025 mg/kg Limiting permissible concen-
361 blooded tration
animals
rat & 0.5 mg/kg Decrease in immunoblologlcal
guinea daily for organism reaction; increase
pig 6 mos in lymphocyte number




43 rat 100 mg/kg Fur ruffled & luster less; lack
daily of desire for food; irrita-
tion of gastro- intestinal
tract; death of most animals
after 6-7 doses
rabbit 0.05 6. Well defined shifts in blood
0.005 leukocytes, nucleic acid con-
mg/kg tent, cholinesterase activity.
daily - glutamic-alanine transferase
6 mos activity, & in blood serum
proteins
41 rabbit 5.0 mg/kg Decrease in cholinesterase
daily for activity; disturbed blood
7 mos sugar curve following heavy
administration of ga lactose: ;
increase in number and total
prottip SH group
i

-------
TABLE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF POTENTIAL  ORGANIC POLLUTANTS
Agent

HEXYLAMINE
ISOPROPYLAMINE

CH3^ CHNH2



6 -MERCAPTODIETHltl,-
AMINE
(HSCH2CH2)2NH
MONOETHANOLAMINE
NH2CH2CH2OH








Source


production of Atra-
zlne (a pesticide)




pesticide; found in
waste water from
plants manufacturing
the pesticide
production of dyes,
solvents, Pharmaceu-
ticals, detergents &
some perfume; used in
precision instrument
construction, avia-
tion, shipbuilding &
others as an inhibi-
tor of metal corro-
sion


i
Acute Toxlcity
Ref Species LD50 mg/kg 96 hr JLm LC5Q ^
mg/1
AMINES
252 rat 670
116 white rat 880
77 820
white mouse 600



114 rat 650
mous e 550
rabbit 350
341 mouse 15,000
77 rat 20,000
2,140







Chronic Toxiclty
Ref Species Dose Effect


116 labora- No appreciable cumulative
tory effects; affects CNS
animal
361 warm 0.05 mg/1 Limiting permissible concentra-
blooded tion
animals
114 rabbit 5 mg/kg Decrease in cholinesterase .icti-
daily for vity; pathological changes in
5-1/2 mos gastro-intestinal tract;
slight change in blood sugar
curve
341 rat 0.5 mg/kg Weight change; sick & lethar-
daily for gic; cyanosis; decrease in
7 mos cholinesterase activity; in-
crease in weight of liver;
decrease in blood prothrombin
0.025-0.25 Decrease in blood prothrombin
mg/kg daily
for 7 mos

rabbit 0.5 mg/kg Decrease in cholinesterase acti-
daily for vity; decrease in carbohy-
7 raos drate metabolism in 1 rabbit


-------
TABLE  111 (CONT.)  -  ACUTE  AND  CHRONIC  TOXICITY OF  POTENTIAL ORGANIC POLLUTANTS
        Agent
     Source
                                                               Acute Toxicity
                                            Ref   Species
                                       LD50 mg/kg
                             96 hr TLm
                                mg/1
                                                                                     LC50 mg/1
                                                                                               Chronic Toxicity
                                                                                                Ref    Species
                                                                                                                  Dose
                                                                                                                              Effect
PHENYLHYDRAZINE
TRIETHANOLAMINE

          .CHjCHjOH

                .OH


TRIETHYLAMINE
                                                                          AMINES
manufacture of dyes;
& as a reagent for
sugars, aldehydes &
ketonea; chemical
treatment of water in
hot water supply sys-
tems; user  in prepar-
ation of synthetic
fibers, films & plas-
tics, as softeners &
plastlclzera in manu-
facture of rubber, as
Inhibitors of plant
growth, aa detergents
& softeners in the
textile Industry
92  rat           188

    white mouse   175
    guinea pig    80

    rabbit        80
                                            77  rat
                                                              8680
                      process of organic
                      synthesis In the pro-
                      duction of herbicides
                      & accelerators for
                      synthetic rubber
                      176  white mouse   545.8
                      77   rat          460
                                                                                                176   rabbit
                                                                                albino
                                                                                rat


                                                                          177    rat
                                                                     6 mg/kg
                                                                     daily for
                                                                     7 mos

                                                                     54.5 mg/kg
                                                                     daily for
                                                                     2 mos

                                                                     10.0 & 1.0
                                                                     mg/kg daily
                                                                                                                             Disturbance  In carbohydrate
                                                                                                                               function of  liver
                                                                                                       No cumulative  effects
                                                                                                                             Significant changes in electro-
                                                                                                                               encephalogram & conditioned
                                                                                                                               reflexes

-------
TABU III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

AROMATIC
3 ,4-DICHLORANILINE
NH_
x4.
CLB
cl
o-NITROANILINE
m-NITROANILINE
p-NITROANILINE

p-PHENYLENEDIAMINE
(URSOL)
NH2 \ / HH2




i
Source








effluent from aniline
dye & fur dyeing
plants



Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLm LC50 mg/1
tug/1
AMINES



169 mouse 1246.1
guinea pig 2350
269 rat 700
guinea pig 450
269 rat 1500
guinea pig 450



Chronic Toxicity
Ref Species Dose Effect

>7 rat 20 mg/kg Change In neutrophil phagocy-
daily tosis
i
i

269 rat Spasms; increased quantity of
hemoglobin, erythrocytes, &
reticulocytes, the phenomenon
of Heinz bodies, leukocytosis.
neutrophilis, lymphopenia
(acute intoxication)
269 rat Same as o-Nitroaniline except
had inhibitions & no spasms
269 rat Same as o-Nitroaniline

461 rabbit 0.05 mg/kg Change in blood sugar; induced
daily for allergic sensitivity
6-7 tnos
460 rabbit 0.5 mg/kg Change in general condition &
daily for behavior; increase in number
7 mos of reticulocytes; disturbed
liver glycogenic function;
disturbed carbohydrate liver
function; induced allergy
sens it ivi tv
0.5-5.0 Ciisrge in conditioned reflexes ,
ng/kg daily
for 7 raos
1
f
! '

-------
TABl£  III (CONT.)  - ACUTE AND  CHRONIC TOXICITY  OF  POTENTIAL  ORGANIC  POLLUTANTS
        Agent
QUARTERNARY

ALKYLDIMETHYLBENZYL-
AMMON1UM CHLORIDE
     CH.-N-CH..
      •3 H  3 C1

ALKYLDIMETHYLCHLORO-
BENZYLAMMONIUM
CHLORIDE
BENZETHONIUM CHLORIDE
(HYAMINE 1622)

CETYLDIMETHYL ETHYL-
AMMONIUM CHLORIDE

      j. .CH,
CHOLINE CHLORIDE

        CH3

HOCH,CH,N±CH.C1-
    22,   '3
        CH,
                            Source
synthetic surfactant;
used in textile, min-
ing, metal-working,
food, paper & other
industries, in agri-
culture, & as deter-
gents

synthetic surfactant;
used in textile, min-
ing, metal-working,
food, paper 6. other
industries, in agri-
culture, & as deter-
gents

pesticide
synthetic surfactant;
used in textile, min-
ing, metal-working,
food, paper & other
industries, in agri-
culture & as deter-
gents
                                                               Acute Toxlcity
                                             Ref    Species
                                            138  albino rat
                                            138  albino rat
                                            17A  coho  salmon
                                            138  albino  rat
                                            468  human
                                                              LD50 mg/kg
                                                              340
                                                              2000
                                                              60
                                                   96 hr ,TLm
                                                      mg/1
                                                                                     LC50 mg/1
                                                                          AMINES,
                                                                          53 (48 hr)
                                                              5-20 g/1  -
                                                              minimum to affect
                                                              human organism
                                                                                                                      Chronic  Toxicity
                                                                                                 Ref
                                                                                                       Species    Dose
                                                                                                                               Effect
                                                                                                138    human
                                                                                                                              Skin  irritation;  CNS  poison
                                                                                                138    human
                                                                                                                              Skin irritation;  CNS  poison
                                                                                                 138    human
                                                                                                                              Skin irritation;  CNS  poison

-------
TABLE  III  (CONT.) -  ACUTE  AND CHRONIC  TOXICITY OF POTENTIAL  ORGANIC  POLLUTANTS
        Agent
                            Source
                                                              Acute Toxicity
                                            Ref   Species
                                       LD50 mg/kg   96 hr TLm   LC50 mg/1
                                                     mg/ 1
                                                                                               Chronic Toxicity
                                                                                                Ref    Species    Dose
                                                                                                                              Effect
 DIQUAT
pesticide
              2 Br~
 LAURYL IMIDAZOLINE     surfactant
 PARAQUAT
 QUARTERNARY AMMONIUM
 CHLORIDE
 (PREPARATION 34)

 (R)4N+C1~
 QUARTERNARY PYRI-
 DINIUM
pesticide
                       surfactant
component  in deter-
gent or cleaning
formulation
173  rat
174  chinook
     salmon
                     397, rat
                     77
                                            124 rat
                                            173
                     467  rat

                          mouse
                                                              400-440
                                                              3200
                  lOOd1
                  1109

                  90? v  (dermal)
                  112-200
                  750

                  744
                                                                        AMINES
                                                                         38.5 (24 hr)
467   albino     0.05,  0.5    0.05 had no effect on animals;
      rat &      & 10 mg/kg     alterations in transaminase
      rabbit     daily  for      activity; inhibition of  cho-
                 6 mos          linesterase activity at  0.5
                               mg/kg only; inhibition of
                               blood catalase;  decrease in
                               ascorbic acid content in
                               hepatic tissue;  histological
                               variations in organs
397  rat           200-250

     mouse         470-2500

     guinea pig    200

     rabbit        400

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

STERINOL "^ Br-
C H
HITRItES 16 33
ACETONE CYANOHYDRIN
(CH3)2C(OH)CN


ACETONITRILE
CH3C"N


ACRYLONITRILE
CHjCHCN





Source

detergent





petrochemical



pesticide; used in
manufacture of plas-
tics & synthetic
rubber





Acute Toxlcity
Ref Species LD50 mg/kg 96 £r "*> LC5Q mg/1
AMINES
20 rat 250

365 rat 13.3
mouse 2.9
guinea pig 9.0
rabbit 13.5
77 rat 3800
252 bluegill 1850
fathead 1000
guppy 1650
340 rat 81-106
252 pin perch 24.5 (24 hr)
bluegill 11.8
fathead 14.3-18.1
guppy 33.5



Chronic Toxicity
Ref Species Dose Effect



365 rat 0.0005 Affect on blood morphology.
mg/kg daily catalase and chollnesterase
for 6 mos activity, vitamin C concen-
trations and conditioned
reflexes




454 rat 1 mg/kg Depressed response to weak stim-
daily for ulation and the appearance of
6 mos narcotic, equalizing and para-
doxical phases
rabbit 10 mg/kg Slight microcellular prolifera-
daily for tion in the interstitial
6 mos kidney tissue & some homogen-
ation of blood vessels in
internal organs

-------
TABLE III (CONTJ - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL  ORGANIC POLLUTANTS
Agent

ADIPONITRILE
NC(CH2)4CN



BENZONITRILE
/7~\
Vs-/0"
LACTONITRILE
CH3
H-C-OH
CN
LETHANE 384
CH3(CH2)3-0-(CH2)2-0-(
OXYDIPROPIONITRILE
NCCH2CH2-0- CH CH2CN

Source

production of nylon;
petrochemical



petrochemical


petrochemical



pesticide
CH2)2-SCN
petrochemical


Acute Toxicity
Ref Species LD50 rag/kg 96 h^ TLm LC5Q fl
mg/1
AMINES
196 rat 105
white mouse 48
rabbit 19.4
449 bluegill 720
fathead 820
guppy 775
449 bluegill 78
fathead 78
guppy 400
449 bluegill 0.90
fathead 0.90
guppy 1.37
pin perch 0.215 (24 hr)
340 rat 90
49 1190
(50% active agent)
173 90-300
77 rat 2830
449 bluegill 4200
fathead 3600
guppy 4450
Chronic Toxicity
Ref Species Dose Effect

196 Change in internal organs &
behavior















-------
TABLE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF  POTENTIAL ORGANIC  POLLUTANTS
Agent

THANITE
CH, O
HETEROCYCLIC
ACRIDINE
C6H4CHNC6H4
AMITROLE
(ATA, WEEDA ZOL,
AMINOTRIAZOLE)
| I] 2
HN 	 N
ATRAZINE
HJL If
CH.JCH2N'^rvNHCH (C
CYANURIC ACID
OH^'VOH
N^vJl

Source

tar & gas wastes
pesticide

pesticide
H )


Acute Toxlcity
Ref Species LD50 mg/kg 96 hr TLn LC5Q fl
ng/1
AMINES
340 rat 1600
49 2140 (82% active agent)
49 perch 0.7 (fatal
in 1 hr)
252 rat 14,700
25,000
173 1100-2500
252 red-sided 983.3-1370
shiners
173 rat 2000 1.25 (507. in
251 minnow A36i;48hr)



Chronic Toxicity
Ref Species Dose Effect






249 rat 6. 30 mg/kg Reduced amount of ascorbic acid
guinea daily for in kidneys and spleen of
pig 6 mos guinea pig; dystrophic cbapgcs
in kidnevs
rat & 200 mg/kg Suppression of weight increase:
guinea daily for reduced amount of ascorbic
pig 6 mos acid in spleen & kidneys of
guinea pig: dystrophic changes
in kidneys

-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

2-HTOROXYSIMAZINE
NHC2H5
ISOQUINOLINE
co
MORESTAN
N S
MORPHOLINE
0
H
NICOTINE

,^>-O
^N CH3
PICOLINE
^
Q-m>
Source

pesticii

pesticide

industrial

pesticide



some industrial
wastes

Acute Toxicity
Ref Species LD50 mg/kg 96 hr ,TLm LC50 ma/1
mg/1
AMINES
174 sunfish 65 (fatal
in 1 hr)
perch 100 (fatal
in 1 hr)
124 rat ISOOrf
11009
>2000 (dermal)

124 rat 1050

304 mammal 2-10
124 rat 83 (as sulfate)
285 (as sulfate)
(dermal)
340 rat 10 (as sulfate)
252 55.2
252 rat 1.29


Chronic Toxicity
Ref Species Dose Effect

24',' rat & 250 mg/kg Atrophic gastritis
guinea daily for
pig 6 mos













-------
TABLE III  (CONT.)  - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

PICLORAM JJH,
Cl-j^Sr-Cl
Cl-^j^ C-OH
PROMETRTOE
TT^^n 3
9^3 t y ^3
HC-N'^y'V-CH
CH3 " CH3
QUINALDINE
C10H9N f*VV*3

QUINOLINE
CqH N

l^^jv^N^
WA^





S1MAZINE

n" Cl

7lC.Hc
H 2 5

Source

pesticide

pesticide




coal tar 6> gas plant
wastes

tar & gas wastes









pesticide






Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLn LC50 fflg/1
Dg/1
AMINES


19 rat 2138
mouse 3126



252 trout 5.0 (lethal
in 1 hr)
rat 1230
174 sunfish 52-56 (lethal
in 1 hr)
perch 30-50 (lethal
in 1 hr)
252 <30 - lethal
trout 5.0 (lethal
in 14 hr)
bluegill 5.0 (lethal
in 4 hr)
fish 7.5 - lethal
173 rat 5000
17* rainbow 85 (48 hr Tim)
trout

174, chinook 6.6 (48 hr)
252 salmon
251 minnow 0.5 (lethal
in 3 days)
Chronic Toxicity
Ref Species Dose Effect

182 bird No chronic toxiclty

19 0.625 mg/kg Affects conditioned reflexes,
daily for blood composition, carbohy-
6 rnos drates. metabolism, and
histology




2^2 Paralyzes respiratory muscles









249 rat & 100 mg/kg Suppressed weight increase;
guinea pig daily for increase in number of leuco-
6 mos cytes; decrease in cholines-
terase activity in blood;
atrophic gastritis



-------
TABLE  III (CONT.)  - ACUTE  AND  CHRONIC  TOXICITY OF  POTENTIAL  ORGANIC  POLLUTANTS
       Agent
STRYCHNINE
CARBOXYLIC
ACRYLIC ACID

CH -CHCOOH
ADIPIC ACID

HOOC(CH2)4COOH


BENZOIC ACID

CgHjCOOH
BUTYRIC ACID
CAFROIC ACID
CHLORENANTHIC ACID

       6C
Cl(CH2)6COOH
                           Source
                      pesticide
                      Car & gas wastes
                      effluent  from pro-
                      duction of enantha
                      fiber
                                                              Acute  Toxicity
                                           Ref   Species
                                                             LD50 mg/kg  96 *>r TLa   LC5Q mg/1
                                           304  rat
                                                             4.0tf )
195 rat           1250
    white mouse   830
    rabbit        250

88  bluegill
174  sunfish

435, mosquito
252  fish

88   D. magna
                                           88   bluegill
                                           215  white mouse   1800
                                                                        AMINES
                                                                    (subcutaneous)
                                                                     ORGANIC ACIDS
                                                                        <330 (24 hr)
                                                                        550-570 (lethal
                                                                        in 1 hr)
                                                                        180
                                                                         61  (48 hr)
                                                                        >150-<200 (24 hr)
                                                                                                                     Chronic Toxicity
                                                                                               Ref    Species    Dose
                                                                                                                             Effect
                                                                                               195   mouse
                                                                                               215   rat
                                                                                                                5  0.25
                                                                                                                mg/kg
                                                                                                                daily for
                                                                                                                2  mos
                                                                                                                            Physiological effects
                                                                     200 mg/kg    Slight decrease  in choline-
                                                                     daily for      sterase  activity
                                                                     2-1/2 mos

-------
TA3LE III (CCNT.) - ACUTE ANO CHRONIC TGXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

CHLORENANTHIC ACID
(Cont.)







CHLOROPELARGONIC ACID
Cl(CH2)gCOOH
CHLORUNDECANOIC ACID
C1(CH2) 1QCOOH
CITRIC ACID
C6H8°7
DALAPON
(DOWPON)
CH,CCl,COONa
3 2




Source










effluent from pro-
duction of enantha
fiber
effluent from pro-
duction of enantha
fiber
industrial waste

pesticide







Acute Toxicity
Ref Species LD50 mg/kg 95 hr TLm LC50 fi
mg/1
ORGANIC ACIDS









215 white mouse 3000

215 white mouse 6000

449 D. magna 185 (fatal in
10-17 hr)
198 albino rat 4700
252 6590-8120
173 4000-9300
198 white mouse 7100
174 coho salmon 340 (48 hr)
438 bass >1000 (48 hr)


Chronic Toxicity
Ref Species Dose Effect

215 rat & 5 mg/kg No significant change in leuko-
rabbit daily for cyte number, blood sugar,
6-1/2 mos ; blood cholinesterase or con-
50 mg/kg ditioned reflexes
daily for
6-1/2 mos
rat 300 mg/kg Increase in leukocyte number
daily for
1-1/2 mos
rat 300 mg/kg Increase in leukocyte number
daily for
1-1/2 mos




!99 albino 235 6. 940 At 940 mg/kg animals showed a
rat mg/kg daily decrease in weight gain;
for 2 mos decrease in serum SH groups;
increase in vitamin C content
of suprarenals; increase in
weight coefficient of liver,
kidneys, spleen, thyroid,
pituitary & suprarenals;
his to logical changes with
both doses

-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

DALAPON (Cont.)






2 ,4-DB

	
Source








pesticide

0
II
Ul -ff V 0-CH2-CH2-CH2-C-OH
\=/
Cl

DDA

Cir^\
c^""00"
DELRAD
CH COOH
x>
-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

ENDOTHALL
Xts/COOH
•sl^COOH
GLUTARIC ACID
LACTIC ACID
C3H6°3
MALEIC ACID
Hv 	 'COOH
T
ir""- COOH
MALEIC ANHYDRIDE
»-c
L:_C>
MALONIC ACID
HOOC CH2COOH
MCFB
135
88 bluegill 330 (24 hr)
449 D. magna 191 (fatal
In 6-48 hr)
rat
435 mosquito 230
fish

88 bluegill 150 (24 hr)

173 rat 680
174 blueglll 15 (48 hr)
largemouth 10 (48 hr)
bass
Chronic Toxlcity
Ref Species Doee Effect





229 rat 0.06 mg/kg Affects glycogen synthesizing
daily for liver function
6 mos
rabbit 6 mg/kg Decrease In phagocytic activity
daily for
5 moi
232 rabbit 2.5 mg/kg Disturbance In liver glycogenic
daily for synthesizing function; some
6 nos hlstological changes
5 mg/kg Change in phagocytic activity
dally for
5 mos






-------
TABlf III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

OXALIC ACID
?1
HO-C-C-OH
PHTHALIC ACID
	 ^-COOH
(XcOOH
-TANNIC ACID
 COOH
TCA
CCljCOOH
Source





pesticide

pesticide


Acute Toxtcity
Ref Species LD50 mg/kg 96 hr *Lm LC50 mg/1
mg/1
ORGANIC ACIDS
88 bluegill 4000 (24 hr)
435 mosquito 1350
fish
258 rat 1100
435 mosquito 37
fish
174 bluegill 90 (48 hr)
largemouth 55 (48 hr)
bass
252 laboratory 300-1500
animals
174 bluegill 1750 (48 hr)
largemouth 1250 (48 hr)
bass
173 rat 1500
252 *" 3300-3370
174 channel cat >2000 (48 hr)
252 >2000
Chronic Toxicity
Ref Species Dose Effect



258 labora- 0.56 mg/kg Reduces thrombocyte cone.,
tory daily for increases bilirubin excre-
animals 6 mos tion, morphological changes
in internal organs




252 rat 0.3%/day Inhibited growth rate
for 4 mos


-------
 TABlf  III  (CONT.) -  ACUTE AND  CHRONIC  TOXICITY OF  POTENTIAL  ORGANIC  POLLUTANTS
        Agent
SULFATES

ALKYL SULFATE
R-0-SO--

3.9-DIETHYL-TRI-
DECVL-6 SULFATE
                  "SO
                            Source
surfactant
 • V* ?              i  **
       "^CH-(CH2)2-CH-(CH2
2-ETHYLHEXYL SULFATE
7-ETHYL-2-METHYL-
UNDECYL-4 SULFATE
                      surfactant
                                                              Acute Toxiclty
                                            Ref   Species     LD50 mg/kg
                                                                                   LC50 ng/1
251 fathead


397 rat           1430

    guinea pig    425



397 rat           4125

    guinea pig    1520
                                                                    ORGANIC ACIDS
                                                  5.1-5.9
                                                                        397   rat
                                                                                              397   rat
                     397 rat           1250

                         guinea pig    650
                                                                                                                   Chronic Toxicity
                                                    Ref    Species    Dose
                                                                                                      Effect
65 rag/kg
daily for
30 days
                                                                                                     No effects
                                                                                         175 mg/kg    No effects
                                                                                         30 days
                                                                                                    rabbit     100 mg/kg    Noticeable effect
                                                   397   rat
                                                                   25 mg/kg
                                                                   30 days
            None

-------
 TABl£  III  (CONT.)  - ACUTE AND  CHRONIC TOXICITY  OF  POTENTIAL  ORGANIC  POLLUTANTS
        Agent
1AURIC DIETHANOLAMIDE
SULFONATE
             H2CH3OH
                           Source
                     surfactant
LAURYL ALCOHOL
SULFATE EO
LAURYL GLYCERYL
SULFATE
LAURYL SULFATE
                      surfactant
                      surfactant
                      surfactant
                                           397  rat
                                                             Acute Toxicity
Ref   Species     LD50 mg/kg
                                                                       96
                                           397  rat
                                           397  rat
                                           397 rat
                                                                                  LC50 mg/1
                                                                   ORGANIC ACIDS
                                                            2700
                4150-9350

                1170-7600
                                                            1820
                                                            1000-2730
                                                                                                                  Chronic Toxicity
                                                  Ref    Species    Dose
Effect
                                                                                             397   rat
                                                                                             397
                                                                                                   rat
                                                                  5000 ppm
                                                                  in diet
                                                                  2 yrs
                                                                                                                         None
                                                                  30 mg/kg     None
                                                                  160 days
                                                                  10,000  ppm   None
                                                                  in food
                                                                  2 yrs
                                                                  60 mg/kg     None
                                                                  5 wks

-------
TABLE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

IAURYL SULFATE
(Cont.)


SESONE
(CRAG HERBICIDE I)
ctO" OCH2CH2OS°3Na
SULFONICS
ALKYLARYL SULFONATE
9^*

AUKYl^SULFONATE
ii
R-S-OH
0
4-AMTNO-m-TOLUENE-
SULFONIC ACID
NH2
Source




pesticide
surfactant


surfactant
industrial waste

Acute Toxlcity
Ref Species LD50 mg/kg 96 Jjr TLm ^.^ ^
ORGANIC ACIDS



252 rat 640-1330
700-1400


81 rat 2700
3000
435 mosquito 375
fish

Chronic Toxicity
Ref Species Doae Effect

397 mouse 10,000 ppm None
in food
3 mos
dog 135 mg/kg/ None
day
guinea 2000 ppm None
pig H20 180
days
252 dog 360 mg/kg/ None
day in diet
for 1 yr.
397 rat 700 mg/kg/ Some deaths
day for
2 mos
guinea 2000 mg/1 None
pig in water -
180 days
252 human 100 mg/day No effect
4 mos.
397 rat 0.1 IH None
50/day for
45 days


-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TCXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

ANTHRAQUINONE- a
SULFOljATE. Na
oco
BUTYLBIPHENYL1
SULFONATE
BUTYLPHENYLPHENOL
SULFONATE
BUTYL SULFONATE, Na
3 2 2 2 j
p-CHLOROBENZENE
SULFONATE, Na
2-CHLOROTOLUENE-4-
SULFONATE, Na
DECYLBENZENE
SULFONATE
(L y- 803"
C10H21 ~~
Source



surfactant
surfactant




surfactant
Acute Toxlcity
Ref Species LD50 rag/kg 96 hr ,TLm LC50 mg/1
mg/1
ORGANIC ACIDS
88 0. magna 50

397 mouse 3400
397 mouse 2200-3800
88 D. magna 2700

88 D. magna 2150
88 bluegill <1374 (24 hr)
397 mouse 2000
77 albino rat 2320
Chronic Toxiclty
Ref Species Dose Effect




397 guinea 2000 mg/1 None
pig in water
for 180
days


292 rat & 250 mg/kg No effect
rabbit daily



-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

2.5-DICHLOROBENZENE
SULFONATE, Na , .
2j - Na+
O"cl
DIOCTYL SUCCINATE
SULFONATE
0-C-0-C8H16S03
1 2
0-C-0-C8H16S03



DODECYLBENZENE
SULFONATE
jSO.H
C12H25
DODECYL DIPHENYL
ETHER SULFONATE
R _ o
Source



surfactant



surfactant

surfactant
i
Acute Toxicity
Ref Species LD50 mg/kg 96 ^r/TLm LC50 mg/1
ORGANIC ACIDS
88 D. magna 938

397 rat 1900
mouse 4800



81 rat 2300

77, rat 700
397

Chronic Toxicity
Ref Species Dose Effect



397 rat 200-900 None :
mg/kg/day
6 mos
mouse 4 mg/day None
7 mos
rabbit 500 mg/kg/ Some deaths
day 24 wk.
rabbit 250 mg/kg/ None
day 5 mos
dog 250 mg/kg/ None
day 24 wk.
monkey 125 mg/kg/ None
day 24 wk.
guinea 2000 mg/1 None
pig In H20
180 days
241 trout 5 mg/1 Spermotocytes lost their
mobility; fertilized eggs
killed
carp sublethal Growth rates affected
fry amounts



-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

ETHYLPHENYLPHENOL
SULFONATE
0tt\==/\=/~ CH2™3
ISOPROPYL NAPHTHALENE
SULFONATE
ra-NITROBENEZ^NE
SULFONATE. Na
^!°3~
4-NITROCHLOROBENZENE
2-SULFONATE, Na
^~^ Cl
4-NITROTOLUENE-2-
SULFONATE, Na
HjC-^ \-N02 Na+
so3- ~
Source

surfactant

surfactant
11
it

11


Acute Toxicity
Ref Species LD50 rag/kg 96 J^™* LC50 mg/1
ORGANIC ACIDS
77, rat 2000
397

397 rat 1900
88 D. nutgna 5067
88 bluegill 948-1474

88 bluegill <1440 (24 hr)


Chronic Toxicity
Ref Species Doae Effect


|








-------
TABLE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

OLEOYUffiTHYL TAURIDE
?C!H3
C17H33C-N-CHCH2CH2S03B


AMYL ACETATE
CH3C02C5HU
ARAMITE

Source

surfactant







pesticide
C1CH -0-S-0-CH3-CH -0-/~\C CH
Z^ 2 \ — / l -3'3


BINAPACRYL
9 H
0-C-C-C(CH3)2
i ir''\ ^
^p CH2C^I3
N02
BUTYT, ACETATE
0
H





pesticide





industrial manufacture
of plastics, lacquer,
artificial leather,
photographic films




Acute Toxiclty
Ref Species LD50 mg/kg 96 >>r Tim LC50 ^^
ORGANIC ACIDS
397 rat 4000
mouse 6300-6600


ESTERS
435 mosquito 65
fish
252 rat 6300
3900
mouse 2300
449 bluegill 480
rainbow 730
trout
124 rat 63cf
58?
rat 8lOa )
iinn \ (dermal)
/tuy )
173 58-225

252 rat 4130
46 13-100
rabbit 3200
mouse 7700
252 7060
46 guinea 4700
pig
Chronic Toxiclty
Ref Species Dose Effect

397 rat 20,000 ppm None
in food
4 mos
guinea 2000 ppm None
pig in water



252 rat & 500 mg/kg None
dog in diet of
rat 2 yr

















-------
TABLE II! (CONT.)  - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

BUTYL MESITYL OXIDE
(INDALONE)
0=(~f^3
CHLOBOBENZILATE
OH
2,4 DEF
E:I-^V-OCH ,CH,O- p
\~/ Z 2 J3
DIBUTYL PHTHAIATE
0 0
•L^~vJ
C4H90~&~^_/<:OC4H9
DIETHYL MALEATE
CH3CH2OOC /COOCH2CH3
H H


Source

pesticide

pesticide
pesticide

effluent from plants
manufacturing kar-
bophos



Acute Toxicity
Ref Species LD50 rag/kg 96 hr ,TLm LC50 mg/1
mg/1
ESTERS
340 rat 7400

124 rat 1040*
12209
>5000 (dermal)
\
451 rat 7.5
173 850
340 rat 1200-20,000
346 rat 1350
mouse 2590
guinea pig 1450



Chronic Xoxicity
Ref Species Dose Effect




451 rflt & Inhibition of brain choline-
monkey sterase activity

346 rabbit 100 mg/kg Increase in gamma-globulin; de-
day, 6 mos crease ir. albumin; neutro-
philic leukocytosis; increase
in vitamin C in blood; bron-
chial pneumonia; slight fatty
liver infiltration
application Irritation
to skin and
mucous mem-
brane

-------
TABLE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent
DIMETHRIN
CH CH3 CH
'\ T A ? Jt
C-C-t 	 ^-C-0-CH2
DIMETHYL GARB ATE
^7\XOOCH3
DIMETHYL PHTHALATE
kJ'jjOCHj
D IMETHYLTEREPHTHALATE
DINOBUTON
(DESSIN) H p
Source
pesticide
CH
y
pesticide



pesticide
-CH3
Acute Toxlclty
Ref Species LD50 rag/kg 95 hr ™* LC50 mg/1
ESTERS
124, rat >15,000
173
340 rat 1150
340 rat 8200

325 white rat 2000 (did not lead to death)
mg/kg
124 rat 59cf
719
1500-2000rf (dermal)
>2000 (dermal)
Chronic Toxicity
Ref Species Dose Effect







-------
TABLE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

DR10NE
S102 +
pyrethrins +
plperonyl butoxide
ETHYL ACETATE
-0-H-CH
METHYL BENZOATE
o
p y-c-ocH3
METHYL HEXAFLUORO-
2-BROMOBUTYRATE
C?3 / r '3
METHYL HEXAFLUORO-
ISOBUTYRATE
3 ^CHCOOCH3
METHYL PERFLUORO-
METHACRYIATE
^•CCOOCH.,
Source

pesticide



refrigerants, pro-
pellants, fire ex-
tinguishers, solvents

refrigerants, pro-
pellants, fire ex-
tinguishers, solvents

refrigerants, pro-
pel lants, fire ex-
tinguishers, solvents

Acute Toxicity
Ref Species LD50 mg/kg 96 hr ,TLm LC50 mg/1
mg/1 ^
ESTERS
340 mammal 0

221 rat >5000
294 5620
221 white mouse >5000
27 rat 3540
mouse 3000
106 rat 980

106 rat 300

106 rat 220

Chronic Toxicity
Ref Species Dose Effect



221 labora- 1000 mg/kg None
tory in food for
animals one month
27 labora- 500 mg/kg Various physiological changes
tory 1-1/2 mos
animals







-------
 TABLE  III  (CONT.) - ACUTE AND  CHROWC  TOXICITY OF POTENTIAL  ORGANIC  POLLUTANTS
       Agent
                           Source
                                                             Acute Toxlclty
                                           Ref   Species
                                                            LD50 mg/kg  96 hr TLn   LC5Q
                                                                                                                   Chronic Toxlclty
                                                                                              Ref    Species    Dose
                                                                                                                            Effect
METHYL TETRAFLUORO-
PROPIONATE
CF3-CHF-CO-0-CH3
MGK REPELLENT 326
          0
OMITE
     OSOCH2C«CH
OVEX
(OVOTRAN)
                      refrigerants, pro-
                      pellents, fire ex-
                      tinguishers, solvents
                      pesticide
                   H.CH.
                                           106  rat
                                           340  rat
                                           124  rat
PROPYLISOME
          COCHjClLCH
              '  i  '
                   3
                 ;2CH2Cii3
                      pesticide
                      synergist
                                           252  rat
                                           449  bluegill
                                               rainbow
                                               trout
                                           340  rat
                                                                         ESTERS
                                                            ~10,000
                                                            5230-7230
                                                             1480
                                                            2000
                                                            5000-15,000
                                                                                   870
                                                                                   860
                                                                                              252    rat
1000 mg/kg
in diet

10,000
mg/kg
in diet
Minimal liver damage


Adverse growth and pronounced
  liver and kidney damage

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

PYRETHRINS

Source

pesticide


3^C £>
CH /\ ° i — T
R>cAX-.-n
c?3

SESAME OIL
mixture of tri-
glycerides
STEAROYL EO

C18H3?c!-(CH2CH20)nH
TABUTREX
CH L(CH
CH2C-0-(CH2)3CH3
0
VINYL ACETATE
H-OCH-0-CCH,
i1
I


synergist


surfactant


pesticide





Acute Toxicity
Ref Species LD50 rag/kg 96 hr TLm LC50 A
ng/1
ESTERS
340 rat 200-2600
252 200
449 bluegill 78
rainbow 56 •
trout
252 man fatal dose
for 70 kg
man is 50 g
340 rat >2000-2270


397 rat 53,000-64,000
hamster 20,000-27,000
rabbit 12,000 +
340 rat 8000


133 rat 2120
77 2920
133 mouse 1613
Chronic Toxicity
Ref Species Dose Effect





















-------
TABlf III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

WARFARIN
QC^C<^
OH 0^XCH
AMIDES
ACET AMIDE
CHjCONHj
BAYLUSCIDE
(BAYER 73)
	 .OH Cl
Source

pesticide



refinery waste

pesticide


/~~\-$ W^~~\-NO
\ — / " \— /' 2
cr





CAPROIACTAM
0
,„_!!
j Y
~N
-------
  TABLE III  (CONT.)  - ACUTE AND  CHRONIC  TOXICITY OF  POTENTIAL ORGANIC  POLLUTANTS
        Agent
                           Source
                                                              Acute Toxlclty
                                            Ref   Species
                                                            LD50 mg/kg  96 hr TL
                                                                                    LC5Q
                                                                                                                    Chronic Toxiclty
                                                                                               Ref    Species    Dose
                                                                                                                            Effect
                                                                  AMINE DERIVATIVES
CAFTAN
(ORTHOCIDE)
                      pesticide
  a
        \  -
          Tl-S-C-Cl
         /   Cl
                                           252  rat

                                           173
                                           252  rabbit
                                                             15,000
                                                             9000
                                                             8400

                                                             3160
DICYANODIAMIDE
NH-CNHCN
DIETHYLTOLUAMIDE
(DEBT)
                                           121  laboratory    50 mg/kg
                                                animals       (not  toxic)
D IMETHYLFORMAMIDE
     CH3

HEMPA
                      pesticide
                      effluent from acrynll
                      manufacturing plants
                      pesticide
                                          340  rat
                                                            1950
                                           124 rat
                                                            2650o-
                                                            3360?
                                                            3500-4500 (dermal)
     CH
            CH
              3
  CH
  CH/
                                                                                              457    rabbit     >250 mg/kg   Reduced respiration rate

                                                                                              456    rat        1 g/kg      Affected central nervous system

-------
TABl£ III (CONT.)  - ACUTE  AND CHRONIC  TOXICITY OF  POTENTIAL ORGANIC  POLLUTANTS
Agent

METEPA
U T* W
/ V
METHACRYLAMIDE
?,
CH2"C-CNH2
METHYLOUffiTHACRYL-
AMIDE
*CK 264 p CH3
N\X^y/ 2
SULFANILAMIDE
NU_ -(' y~SO,NH,
SULFATHIA20LF.
(NORSULFAZOLE)
•F~\ x^N
H-N^ ^SOjHHjl |
I
Source

pesticide


aynergist



Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLm LC5() ^
1Dg/l
AMINE DERIVATIVES
124 rat 136tf
213?
183 (dermal)

392 rat 1223
mouse 475
rabbit 1365
392 rat 312
mouse 400
rabbit 328
340 rat 2800
99 mouse 6000


'
Chronic Toxicity
Ref Species Dose Effect



392 labora- 0.05-1.0 Decreased cholinesterase actl-
tory mg/kg vity in blood; increased con-
animals daily centratlon of ascorbic acid
in kidneys; decreased con-
ditioned reflexes
393 labora- 0.05-1.0 Same as above
tory mg/kg
animals daily
99 rabbit 200 mg/kg Decrease in hemoglobin and total
daily for protein; increase in aldolase
9 mos and aniline transamlnase
94 rabbit 0.5 mg/kg Critical concentration



-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

TEPA
0
A
CARBAMATES
BAYGON
OC-NH-CH.
CARBARYL
(SEVIN)
0-C-N-CH3






Source

pesticide


pesticide
pesticide





Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLm LC5Q ^
mg/1
AMINE DERIVATIVES
124 rat 37
87 (dermal)


124 rat >2400 (dermal)
83-86
340 95-104
173 rat 400
123 white rat 505
309 500
124 850cT
500?
>4000 (dermal)
340 500-700
252 500-2190
cat 125-250
dog 250-795
rabbit 710
174 fathead 12.0
252 6.7-41.0
174 biuegilt 5.5
252 5.6-11.0
44 y 3400
| rainbow 3500
; trout
Chronic Toxicity
Ref Species Dose Effect





123 white No cumulative properties
rat






J ;' f

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent
CHLORPROPHAM
(CHLORO IPC)
0 CH
^Jv-ljI-C-0-CH.
DIMETILAN
CH3 XN~C~>Sr 0-C-Sxc
IPC
(PROPHAM)
Q-gloI3
ISOLAN

0
li
MATACIL
X*^ tt

Source
pesticide


pesticide
U3
H3
pesticide

pesticide


pesticide
ca3

Acute loxicity
Ref Species LD50 mg/kg 96 hr TLn LC50 mg/1
ng/1
AMIKE DERIVATIVES
252 rat 1500
173 3800-8000
174 bluegill 12 (48 hr)
largemouth 10 (48 hr)
bass
252 catfish 86.5
rat 25-64
25-50
252 rat 1000
173 1000-9000

124, rat 23cf
252 139
5 6cf }
f'\ (dermal)
173 12
124 rat AOd1
389
32^9 ) (dermal)
173 30
Chronic loxicity
Ref Species Dose Effect













-------
 TABLE  III  (CONT.)  - ACUTE AND  CHRONIC  TOXICITY OF POTENTIAL  ORGANIC  POLLUTANTS
        Agent
                            Source
                                                              Acute Toxicity
                                            Ref   Species     LD50 mg/kg
                                                                         96
                                                                                     LC50 mg/1
                                                                                                                    Chronic Toxicity
                                  Ref    Species    Dose
                                                                                                                              Effect
 MESUROL
 (METMERCAPTURAN)
CH..-S-A   y-0-C-N-CH,
       Vrr/
METHOMYL
                      pesticide
                       pesticide
        C-N-0-C-N-CH
               H   'J
MOBAM
    0-{!-N-CH,
                      pesticide
 SD-8530

  CH,,
                      pesticide
  CH,-Y   T-O-C-N-CH.
      )r=-/      H   J
   CH3

  TEMIK
                      pesticide
I Cli. -S-C-C=N-0-C-N-CU-
   J   i,H       C     !
                                           124  rat
                                            149
                                                carp
                                            124  rat


                                            173



                                            124  rat
                                            124  rat
                                                                  AMINE DERIVATIVES
                                                             609

                                                             >2000 (dermal)
4.2 mg/fish

0.036 mg/fish  (tropical)

2.0 mg/fish (contact)
ISOrf
1159
>2000 (dermal)
>234
232V
205cf
>2000 (dermal)
                                                             O.So-
                                                             0.69
                                                             2.59 )
                                                                    (dermal)

-------
TABLf  III  (CONT.)  - ACUTE AND  CHRONIC TOXICITY  OF  POTENTIAL  ORGANIC  POLLUTANTS
        Agent
                           Source
                                                             Acute Toxicity
                     Ref   Species     LD50 mg/kg
                                                                       96
                                                                                  LC50 mg/1
                                                                                                                  Chronic Toxicity
                                                                        Ref    Species   Dose
                                                                                                                          Effect
TRANID
          iN-0-C-N-CH.
                      pesticide
ZECTRAN
                      pesticide
          f M—0-C-N-CH3
THIOCARBAMATES

CARBATHION

CH3-N-|-S-Na
pesticide
                                           124  rat
                                                                AMINE DERIVATIVES
                                      19V
                                      >2000 (dermal)
                     124  rat
                                                            25?
                                                            1500-2500 (dermal)
276, white rat     700

278 white mouse   266
                                                                       276
                                                                                                    Atfects cholesterol  level in
                                                                                                      serum & liver; anemia; slight
                                                                                                      cumulative effects

-------
  TABLE  III  (CONT.) -  ACUTE  AND CHRONIC TOXICITY OF  POTENTIAL  ORGANIC  POLLUTANTS
        Agent
      Source
                                                              Acute Toxicity
                                            Ref   Species
                                        LD50 rag/kg  96 hr TL
                                                      tug/I
                                                                                    LC50 mg/1
                                                                                                                     Chronic Toxicity
                                                    Ref
                                                           Species    Dose
                              Effect
 DAZOMET
 (CRAG MYLONE)
 CH3-1
 DIETHYL DITHIO-
 CARBAMATE, Na

 (C2H5)2-N-C-S-Na

 DIMETHYLDITHIO-
 CARBAMATE, NH,

 (CH3)2-N-C-S-NHA
FERBAM
(FERMATE)

((CRj)2NCS2)3Fe
METHAM
(VAPAM)
    H
 CH,N-C-S-Na-2H-0
   3  i        2
 pesticide
pesticide
pesticide
                                                                  AMINE DERIVATIVES
173  rat
49
                                        320-1000
                                        325
                      130 chick embryo  0.0058
                      276, white rat
                      278
                  1458
     white mouse   592
     guinea pig    1680
                      438  fish
                                            252  rat
                                                             4000
                                                             17,000
                                                channe1
                                                catfish
130 chick embryo  0.0022

252 rat           800
173               82
252 mouse         285
                                                   1.0-4.0
                                                   (toxic  level
                                                   for fish)
                                                   2.2
276
                             Affects cholesterol level in
                               serum & liver; anemia; slight
                               cumulative  effect

-------
 TABLE  III  (CONT.)  -  ACUTE  AND  CHRONIC TOXICITY  OF  POTENTIAL ORGANIC  POLLUTANTS
       Agent
                           Source
                                                             Acute Toxicity
                                           Ref   Species     LD50 mg/kg  96  hr Tim   LC50   fl
                                                                           rag/1
                                                                                                                   Chronic Toxicity
                                                                                              Ref    Species    Dose
                                                                                                                            Effect
NABAM
   CH2-p-fi-S~Na+

   I   J    - +
   CH2-N-C-S Na
THIRAM

CH3X.. 8   .  I   ^CT1
                      pesticide
                      pesticide
TRIARAM
bis (Dimethyl thio-
carbamoyl) ethylene
bis  (dithiocarba-
mate)
                      pesticide
™
         >,>§
      CH.-N-C-S
      CH,-N-C-S"
         .E S
                 Zn"
ZIRAM

ra..
  3\M
                      pest ic ide
                      pesticide
                                                                AMINE DERIVATIVES
                                           252 rat           395
                                           130 chick embryo  0.140
                                           124  rat
                                           173
                                           252

                                           252  rabbit
                                                             640rf
                                                             620?
                                                             >2000 (dermal)
                                                             375-1000
                                                             350
                                                             865
                                                             350
                                           130  chick embryo  350
                                                            0.0019
                                           252  channel cat
                                           130  chick embryo  0.0048
                                                                         0.079
                                           124  rat
                                           173
                                                            >5000
                                                            >2500 (dermal)
                                                            1000-8000
                                           130 chick embryo  0.0021

-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent


UREAS
DCU
tCRAG HERBICIDE DCU)
OH H
(C13C-CH-N)2-C-0

DIURON
(KARMEX)
Cl
Cl— 56

252 human lethal dose 326 g/90 kg
rat 3500
173 3600-3700
74 coho salmon 110 (48 hr)
52 shiner 40.1
red-sided 41.5
shiner
50 rat < 12,000 (did not
cause death)
Chronic Toxicity
Ref Species Dose Effect






t















50 rat 50 mg/kg Did not alter urea balance or
organism

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF  POTENTIAL ORGANIC  POLLUTANTS
Agent

ABATE
CH,0. S , 	 ,
3>o-fA_s_>
CH30 \=/ >


ACETOPHOS
F 1
(C2H50>2 SCH2 2H5

AZODRIN
CH30 0 H 0 H
J >f-o-c=d-d-»^
m3° CH CH

Source

pesticide
ry0_rVOCH3
^/ OCH-





pesticide

I
i
Acute Toxlcity
Ref Species U550 mg/kg 96 hr ,""* LC50 mg/1
Bg/1 ^
PHOSPHATE ESTERS
340 rat 1000-3000
173 1000-4000
124 SfiOOrf
13,000?
>4000 (dermal)
299 rat & mouse 4000


202 rat 45
mouse 2 10
guinea pig 27.8
rabbit 45
124 rat 17tf
20$
S i (d— «

Chronic Toxicity
Ref Species Dote Effect

299 rat 200 ppm 707. Inhibition of blood cho-
for 99 days linesterase
in diet
rabbit 10 mg/kg Minor liver damage; liver
daily necrosis
100 mg/kg
daily
ewe 5 mg/kg Inhibition of cholinesterase
while activity
nura ing
offspring
human 256 mg/day No toxic symptoms in 28
for 5 days volunteers
or 64 mg/
day for
4 wks





!

-------
TABLE
(CONT.) - ACUTE AND CHRONIC TOXICITY  OF  POTENTIAL ORGANIC  POLLUTANTS
Agent
BIDRIN
Source
pesticide
m r» PU ^^m
LH«U CH_ CH.,
BROMOPHOS
Cl
^^r~0"\ ^Br
CH.O *— \
Cl
CARBOPHENOTHION
(TRITHION)
2 5
CHLORFENVINFOS
CH3CH,,0 0
CH3CH2°X'cyk
Cl

pesticide

pesticide
Cl

I
Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLm LC50 mg/1
mg/1
PHOS.PHATE ESTERS
173 rat 22-45
309 25
124 21cf
169
42? ^ (dermal)
124 rat 1600rf
17309
>5000 (dermal)
173 3570-5180
124 rat 30cf
109
27j j (dermal)
49 32
173 7-30
124 rat 15cf
139
173 3 Icf )
loo v (dermal)
173 10-155

Chronic Toxicity
Ref Species Dose Effect





i
299 rat 10-15 Death
mg/kg
dog 5000 Tolerates this dose probably
mg/k8 due to its more efficient
detoxication, less readily
available blood levels of
pesticide, slower rate of
brain uptake and less sen-
sitive brain central nervous
system


-------
TABLE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent
CHLORTHION
CH30 \=/~




Source
pesticide





CIODRIN pesticide
CH3 CH3 OCH
tf y— CHOCOCH»C-0-P-OCH3
~ 0
COUMAPHOS I pesticide
( CO- RAD 1
CH3
w>L.O(X






Acute Toxicity
Ref Specie..; LD50 tug/kg 96 *>r TLm LCM ^
ng/1
PHOSPHATE ESTERS
124, rat 880cC
451 9809
1500-4500cf ) ,.„ ,n
41009 ) 
252 rat 550-1510
173 625-1500
252 bobwhite 700
quail
174 fathead 3.2
442 bluegill 0.70
252 human 60 g/70 kg
is fatal
124 rat HOtf
749
375o" )
ini^ \ (dermal)
^029 /
173 125
124 rat 41rf
169
860o" (dermal)
349 90-110
451 100
252 56-230
173 13-180
174 bluegill 0.18
252 fathead 18

Chronic Toxicity
Ref Species Dose Effect
252 dog 15 mg in Questionable red cell
diet inhibition
441 goldfish 0.1 rag /I Effect on cholinesterase
activity - may take up to
40 days to regain normal
activity





451 rat Inhibition of brain choline-
sterase activity





-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

CRESYL DITHIO-
PHOSPHATE
0
CH3^ M-O-P-OH
OH
DASANIT
(BAYER 25141)
Source

f lotoreagent



pesticide

CH3CH20X ,S --^ 0
jS "~0— ( *V- S— CHg
CH3CH20 \=y
DEMETON
(SYSTOX,
MERCAPTOPHOS)
pesticide

CH3CH20 %
P> P-0-CH2-CH2-S-CH?-CH3
CH3CH20
-}-



CH3CH20 ||
"^>P-S-CH2-CH2-S-CH2-CH,
CH3C11?0










Acute Toxicity
Ref Species LD50 mg/kg 96 hr ,TLm LC50 mg/1
mg/1
PHOSPHATE ESTERS




124 rat 4.1rf
1.8?
19o- ) ,. ,.
4.10 ) (dermal)


252 human 0.1 g/ 70 kg x
man is fatal
104 rat 7.5
124 6.2o"
2.5?

g^n ) (dermal)

451 rat 30
49 9.2
252 2.5-40
173 3-5
449 bluegill 0.195
101 fathead 3.6
252, 3.6-4.2
449


Chronic Toxicity
Ref Species Dose Effect

233 rat 2.5 mg/kg Histopathological changes in
daily liver, kidney, heart & lung








441 goldfish 0.1 mg/1 After 24 hr ChE decreased
by 75%
252 dog 2 mg/kg Inhibition of plasma choline-
in diet sterase
5 mg/kg Inhibition of erythrocyte
in diet enzyme
252 cow 0.1 mg/kg Decrease in milk production;
in capsules increase in percent fat
for 3 days

5 mg/kg in Adverse effects on weight gain;
hay for 49 inhibition of red blood cell
days activity
252 sheep 1 mg/kg No toxic effects
single dose

451 human 0.1 g/70 kg Fatal; inhibition of serum and
erythrocyte activity

-------
       TABLE III  (CONT.) -  ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
N>
S

Agent

DIAZINON
Source

pesticide
CH-
/H<"3
CH3CH2°\I oM CT3
CH.CH.O/ \J
CH
3










DICAPTHON
Cl
CH-0^ S V- -v
3 ^-O^/VNO.
CH,0 V^/
j












pesticide






t
Acute Toxic! ty
Ref Specie* LD50 ng/kg 96 hr JLm LC5Q ^
mg/1 °
PHOSPHATE ESTERS
252 human 25.0 g/70 kg
is fatal
124 rat 108-250rf
76-285?
200-9009 ) ,. ..
455? ) {demal)
340 150-220
451 76-108
49 354
252 100-150
125
235
252 rat 435rf
408
293
173 300-600
252 mouse 82
124 rat 400d-
3305

1250? ) ««"»»
340 284-650
252 460
173 330-475

Chronic Toxicity
Ref Species Dose Effect

441 goldfish 0.1 mg/1 407. decrease in cholinesterase
activity after 24 hr
252 dog 6,5 mg/kg Inhibited cholinesterase
daily activity
75.0 mg/kg Depression of red cell cho-
in diet linesterase




















-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

DICHLORVOS
(DDVP)
CHjO^O H ^Cl
CHjO ^-Cl



DIETHYL DITHIOPHOS-
PHORIC ACID

(CH3CH20)2-P-SH
S
DIISOPROPYL DITHIO-
PHOSPHATE, K
s
(CCH3)2CHO)2-P-S" K+
DTMETHOATE
(rvnoN, ROGOR)

^.P-S-CH2-0-N-CH3


Source

pesticide





intermediate in pro-
duction of M-74
(pesticide)


used in ore flotation


pesticide




Acute Toxicity
Ref Species LD50 mg/kg 96 hr,TLm LC50 n
rog/1
PHOSPHATE ESTERS
124, rat SOo1
451 56?
124 107tf ) , . .,
7S^ j (dermal)
340 56-80
25-30
8 guinea pig 80
rabbit 15.0
119 mouse 1000-1250



-.
118 mouse 2600
rat 2960


299 human 30
124 rat 28^ 1959
309 1959
6kf 1959 )
559 1959 ) <.dermal>
215o- 1962
2459 1962
Chronic Toxicity
Ref Species Dose Effect

451 Inhibition of erythrocyte cho-
linesterase activity










118 rabbit 5 mg/kg No significant effects
daily for
5 mos

299 rabbit 5 mg/kg Decrease in cholinesterase acti-
daily for vity; hyperglycemia
6 mos




-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

DIMETHOATE (Cont'd)

-. - -
DIMETHYL-DITHIO-
PHOSPHORIC ACID
CH3°\|
^P-SH
DIOXATHION
(HERCULES 528,
DELNAV)
S
x'OS. "
S
DISULFOTON
(DISYSTON)
Cn - CH » 0 
340 50
173 20-40
173 rat 4
124 6.8cf
2.39
15. Ocf ) ,. ,.
6.09 ) (derraal)
252 2.6-12.5
guinea pig 10.8
42 bluegill 0.064
52 0.07
fathead 2.6-3.7
2.9-4.1
Chronic Toxicity
Ref Species Dose Effect




441 goldfish 0.1 mg/1 40% decrease in cholinesterase
activity in 24 hr

388 rat 1 mg/kg Tolerance of cholinesterase
daily inhibition after prolonged
exposure





-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

DURSBAN

Source

pesticide

C\f^fCi
CH3CH2°\§ xlxjX
CH3CH20/ "°
EPN

\y
^=\S fi~~\
CH3ca/ \=/~ N°2






ETHION

pesticide










pesticide

3 20^~s~cH2-s^\rr2Un3


Acute Toxicity
Ref Species LD50 rag/kg 96 l»r Tin LC50 ^
mg/1
PHOSPHATE ESTERS
124 rat 155cT
829
202tf (dermal)
340 97-276
173 135-163
252 human 0.3 g/70 kg
is fatal
251 rat 36rf
7.79
"** | (dermal)
340 7.65
49 23
252 7-50
173 8-17
101 fathead 0.2
442 bluegill 0.10
124 rat 65cf
279
\^] (dermal)
175 13-34
Chronic Toxicity
Ref Species Dose Effect

379 rat Dursban itself is not a cho-
linesterase inhibitor; oxygen
analog is a potent inhibitor


441 goldfish 0.1 mg/1 507. decrease in cholinesterase
activity after 24 hr
252 rat 225 and Retarded growth
450 rag/kg
in diet
2 yrs
dog 2 mg/kg Increased weight of kidney
dally for
1 yr








-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

FENTHION
(ENIEX, BAYTEX,
TIGUVON)

CH.Ov S — _
Source

pesticide


\p-0 // \v_ S-CH ,
CH30 ^
FOLEX
(MERPHOS)
CVCH^S^^^

GARDONA H_c_cl
C^3\l^lf\
GUIHION
(AZ1NPHOSMETHYL,
BAYER 17147, DBD)

j
pesticide


3CH3
pesticide

pesticide

-^XX^^
f jT x? ,°
^^V.^8 "-CH.-S-P- 0-CH,
i/, 2 1-3
0 OCHj








Acute Toxlcity
Ref Species LD50 mg/kg 96 hr Tim LC50 fi
ng/1 ^
PHOSPHATE ESTERS
124 rat 215d-
2459
330 (dermal)
340 178-310
451 215-245
173 200
124 rat 1475cf
9109
590cf )
& i en \ (dermal)
Duy /
12* rat 11259
>4000 (dermal)
252 human 0.2 g/70 kg
Is fatal
124 rat 13
11
220 (dermal)

49 24
252 11-80
173 7-13
252 mouse 20
174 bluegill 0.0052
252 0.005
Chronic Toxlclty
Ref Speclea Dose Effect

rat Decrease In brain cholinesterase
activity










441 goldfish 0.01 mg/1 50% decrease In chollnesterase
activity











-------
TABLE  III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL  ORGANIC POLLUTANTS
Agent

HERCULES 9699

o
O-fllJHCH.
60-CH C»CH
HRS-1422


"A 0
\ Vo-N-C-NCH.
y*^/ | tj J
CH3
IMIDAN
(PROLATE)
xi S
[ JT • N-CH2-S-P ^*
0
Source

pesticide










pesticide


OCH3
Acute Toxlcity
Ref Species LD50 rag/kg 96 hr TLa LC50 mg/1
ng/1
PHOSPHATE ESTEBS
124 rat 108cf
609

>2400 (dermal)

L24 rat 280
200
>2400 (dermal)



24 rat 113cf
1609

>2000cf ) ,. ,.
>15509 ) 
-------
TABLE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF  POTENTIAL ORGANIC  POLLUTANTS
Agent

MAIAOXON:
SUCCINATE MALAOXON

MALONATE MALAOXON

tt-GLUTARIC MALAOXON

P-CLUTARIC MALAOXON

d-MALAOXON

1-MALAOXON

dl-MALAOXON




MALATHION
(KARBOFOS)
CH.O •>. § H ft
Source

pesticide metabolite

















pesticide


* >P-S-C-C-0-CH,CH-
CH.O-^ | 2 3
* H2C-jj-0-CH2CH3








Acute Toxicity
Ref Species LD50 mg/kg 96 £r "* LC50 mg/1
PHOSPHATE ESTERS

62 mouse 243
66*
215
80*
47.2
10.7*
449.1
379.7*
150 163
40*
249
100*
243
66*
* Tri-o-tolyl phosphate given 24 hrs before
testing mice to prevent degregation of
the compound by carboxylesterases
252 human 60 g/70 kg
is fatal
173 rat 1400-1900
304 1500
124 13759
lOOOrf
>4444 (dermal)
340 900-5800
451 940-1200
49 2590
252 1000-2830
1845
Chronic Toxicity
Ref Species Dose Effect

299 guinea Inhibition of ma lath ion -
pig, esterase activity
mouse,
& rat














441 goldfish 0.1 mg/1 657. inhibition of cholinesterase
activity in 24 hrs
112 rat 1 mg/kg No observable change in cho-
daily for linesterase activity of serum
6 mos or in sugar response curves
451 rat Inhibition of cholinesterase
activity in brain





-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

MALATHION (Cont.)
SUCCINATE MALATHION

MALONATE MALATHION

a-GLUTARIC
MALATHION

13-GLUTARIC
MALATHION

d -MA LATH ION

1-MAIATHION

dl-MALATHION

MALATHION













Source
































Acute Toxicity
Ref Species LD50 rag/kg 96 hr TLm LC50 n
mg/1
PHOSPHATE ESTERS

62 mouse 1942
159*
3090
159*

514
30.8*

3760
183*
150 1014
132*
2357
189*
1942
159*
252 3321
174 channel cat 13.05
101 fathead 12.5
252 salmon 0.12
f ingerling
449 rainbow 0.1
trout
252 red-sided 8.9-9.6
shiner
449 bluegill 0.12
442 0.090
* Tri-o-tolyl phosphate given 24 hrs before
treating with compound to prevent degreda-
tion of the compound by carboxylesterases
Chronic Toxicity
Ref Species Dose Effect
i
































-------
.TABLE  III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL  ORGANIC POLLUTANTS
Agent

MENAZON
Source

pesticide
j 2.
S H5*^!}
3 ^^P-S-CH —is. JL
CH O-^ 2 1™2
METHYLACETOPHOS
(CH30)2P-S-CH2COC2H5
O
METHYLDEMETON
(METHYL SYSTOX,
THIOMETON)
pesticide






CH3°\J
'pP-O-CH.-CH.-S-CH.-CH,
CHJK
3 +
Q
't *\ it
">>-S-CH,-CH,-S-CH,-CH,
CH 0^ 22 23





Acute Toxicity
Ref Specie* LD50 mg/kg 96 hr TLm LC50 ;i
mg/ 1
PHOSPHATE ESTERS
124 rat 1020rf
14509
>2000 (dermal)
173 1200-1600

202 rat 38
mouse 322
guinea pig 214
rabbit 423
173 rat 50-75












Chronic Toxicity
Ref Species Dose Effect

124 rat 0.075 No observable changes in
mg/kg growth; conditioned reflexes,
daily cholinesterase activities,
for 10 phosphate metabolism, SH
mos concentration



47 rat 0.008 Affected conditioned reflexes
mg/kg
daily
0.08, 0.8, Decrease in hemoglobin; de-
& 8.0 mg/1 crease in erythrocyte count;
in drinking increase in leukocyte count;
water & by traces of protein in urine;
stomach no changes in internal organs
tube for at
least 6 mos

6 rabbit 1 mg/kg Increase in erythrocyte count;
daily for increase in leukocyte count;
6 mos decrease in cholinesterase
activity

-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

METHYLPARATHION
(METAPHOS)
CH30/ ° \=/ N°2




METHYL TRITHION

CH1°\S tf~\
CH 3Q>-S-CH2-S -

MEVINPHOS
(PHOSDRIN)
o o
CH.O\1 H ||
'•» >P-0-C-C-C-OCH.
CH,O/ in '3
3 ""3





Source

pesticide





pesticide

-Cl

pesticide







Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLm LC50 mg/1
ng/1
PHOSPHATE ESTERS
252 human 0.15 g/70 kg
is fatal
124 rat 14o-
249
67 (dermal)
252 9-25
173 12-16
101 fathead 8.3
252 7.5-8.3
442 bluegill 1.9
124 rat 98rf
1209
1909 ) (dermal)
173 98-200
369 rat 6.1cf
124 3.79
4.7o' ) ,. ,.
, on * (.dermal)
4.29)
451 4-6
49 6.5
252 6-13.1
173 3-5
252 bobwhite 90
quail
Chronic Toxicity
Ref Species Dose Effect

252 dog 50 mg/kg Decrease in plasma and erythro-
in diet cyte cholinesterase activity
20 mg/kg Decrease in erythrocyte and
in diet possible decrease in plasma
cholinesterase activity
231 rat & 1 mg/kg Change in conditioned reflexes;
rabbit daily for vacuolization of some brain
6 mos cells






451 human Inhibition of cholinesterase
activity of erythrocytes
169 rat Some cumulative effects







-------
TABLE  III  (CONT.) - ACUTE AND  CHRONIC  TOXICITY OF  POTENTIAL ORGANIC POLLUTANTS
       Agent
NALED
(DIBROM)

CH30
CHjO
            - C-C1
            H  Cl
OXYDEMETONMETHYL
CH,0\ II           II
  3    P-S-CH-CH-S-C
PARAOXON
                  N00
                           Source
pesticide
                      pesticide
                      pesticide
                                                             Acute Toxicity
                                           Ref   Specie*     LD50 tng/kg
                                                                            ,
                                                                          mg/1
                                                                                   LC50 mg/1
                                                                  PHOSPHATE  ESTERS
                     124  rat

                     17.1

                     449  bluegill

                         rainbcw
                         trout

                     124  rat
                     173


                     451  rat
                     252
                     174  fathead
                     449
250o-
8009
430
47cf
52?

173o" )
158? )

57


3.0
3.5
                       0.220

                       0.070
                                                                   (dermal)
                                                                       0.33
                                                                       0.25-0.33
                                                                                                                   Chronic Toxicity
                                                                        Ref    Species    Dose
                                                                                                                           Effect
451   rat


      human
Inhibition of cholinesterase
  activity in brain

Inhibition of cholinesterase
  activity in erythrocytes

-------
TABLE III (CONTJ - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL  ORGANIC POLLUTANTS
Agent

PARATHION
(THIOPHOS)
IJ^-O"'















PHORATE
CH3CH20-^J
.xP~S-'CH_~S— L.t
CH3CH20 ^


Source


>2















pesticide




Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLm LC50 M
mg/1
PHOSPHATE ESTERS
252 human 0.1 g/70 kg
is fatal
173 rat 3-6
124 13. Orf
3.69
21. Oo"
6.89
252 3-15
451 6.5
49 8.1
304 mammal 5-10
i49 bluegill 0.056
442 0.095 v
174 fathead 1.4-2.7
383 1>4
449 rainbow 2.0
trout
252 caddisfly 0.001
Acroneuria 0.0001
pacifica
Peteronarcys 0.0032
califorinica
252 rat 2.3o"
1.19
6.2cf ) , . .
2.59 ) 'derma1'
2-3

Chronic Toxicity
Ref Species Dose Effect

441 goldfish 0.1 mg/1 407. decrease in cholinesterase
activity after 24 hrs
239 rabbit 1.0 & 5.0 Fluctuation in cholinesterase
mg/kg daily activity; chronaxy changes in
for 6 mos flexor-extensor muscles; de-
crease in rate of weight gain
5.0 mg/kg Non-specific granular edema
daily for changes in parenchymatous
6 mos organs
human 72 deaths caused by pesticides;
44 were due to organophos-
phates and 33 of these due
to par a th ion















-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

PHOSPHAMIDON
Source

pesticide
CH,0 0 ClO CH CH
3 VI 1 | /CH2CH3
^p-o-c - c-c-tr


RUELENE
IH3NH ^=^ CH3
SARIN
3 ^P-F
SCHRADAN
(OMPA)
/Nv 0 0 ,N\
CH ' "X


pesticide

nerve gas; pesticide

pesticide
«3
CH3
Acute Toxicity
Ref Species LD50 mg/kg 96 hr,TLm LC50 ma/1
ng/1
PHOSPHATE ESTERS
124 "t 24
%% I (dennal)
451 7.5-10
173 15
449 bluegill 0.056
rainbow 2.0
trout
124 rat 635cT
4600
340 950
173 460-1000

252 human 0.01 is fatal

124 rat 9.1&
42?
^ y (dermal)
304 20
173 5
174 fathead 121.0
252 121-135
Chronic Toxicity
Ref Species Dose Effect









252 rat 50 mg/kg Poisoning and diminished growth
in diet in males but not feaiales
2l rag/kg Sotne cholinesterase inhibition


-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

SD-7438
S,S'-benzylidene bls-
(0, 0-dimethyl phos-
phorodithioate)
SUMITHION
(FENITROTHION)
CH3°\li j7~\
/ \ / 2
CH-0 >,u
J ^"-l
TEPP
Source

pesticide



pesticide




pesticide

CH CH 0 0 0 OCH.CH,
2 \« «/ 2 3
p-o-F
CH CH o' OCH.CH.
32 23



THIONAZIN

CH.CH.O S
3 2 v | /9""^v

/ \=N/
CH3CH20' "
TRIBUTYL PHOSPHATE
0
ji
( CTT3(C"2)3-0)3P



pesticide








Acute Toxicity
Ref Specie;; LD50 rag/kg 96 hr TLm LCJO fl
n>g/l
PHOSPHATE ESTERS
124 rat 320rf
2659
>5000 (dermal)

124 rat 740cf
5709
300-400 (dermal)
173 250-673

124 «t l.OSo*
2.49
340 °-5-2-0
551 2.0
173 0.5
174 fathead 1.7
252 1.0
174 channel cat 1.6
252 human 0.05 g/70 kg
is fatal
124 rat 6.4d-
3.59
_* * ufy
' j (dermal)

173 9-16
469 rat 1400
mouse 1200

Chronic Toxicity
Ref Species Dose Effect










252 rat Inhibition of cholinesterase
activity in brain
human 25 ntg Causes severe nervous symptoms
















-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

TRICHLORFON
(DIPTEREX, DYLOX)
CH.O 0 OHC1
3 \« 1 |
Np_C_C-Cl
CH.O/ H Cl
J







TRICHLORONATE
(BAYER 37289)

3 2 X. ^ ^J — ?i
p-o-/ yci
/ \=<
CH3CH^ ^1
ACETALDEHYDK
CH-CHO

Source

pesticide











pesticide





manufacture of plas-
tics, synthetic
rubber, dyes & other
chemical products
Acute Toxicity
Ref Specie:; LD50 mg/kg 96 hr ^ LC50 mg/1
ng/1
PHOSPHATE ESTERS
252 human 25 g is fatal
to 70 kg man
124 rat 630
560
>2000 (dermal)
340 500
252 400-1100
173 650
449 bluegill 5.6
442 3.8
174 fathead 180
449 rainbow 2S.O
trout
124 rat 55cf
34$
isorf ) (de
64? )

ALDEHYDES AND KETONES


Chronic Toxicity
Ref Species Dose Effect



















15 warm blood- 0.5 mg/kg Ineffective dose during
ed animals sanitary-toxicological tests


-------
TABLE III •
CYCLOHEXANONE OXIME
( VNOH
DIPHACINONE
0 ^
" 9 k>
f IT yCH-C-CH
II if^
0 [1



wastes from chemical
industries, gas
plants, coal tar pro-
cesses, or paint
manufacturing
pesticide

effluent from pro-
duction of caprolac-
tam, resins, and from
distillation of cyclo-
hexanone raw materials
intermediary compound
in production of
caprolactam
pesticide
)

3
Acute Toxicity
Ref Species LD50 mg/kg 96 hr *Lm LC50 mg/1
mg/1
ALDEHYDES AND KETONES
252 rat 9750
174 sunfish 14,250 (toxic in
15,050 1 hr)
mg/1
435 mosquito 13,000
fish
88 D. magna 10 (48 hr)
252 rat 46
173 42-46
252 rabbit 7.1
174 chinook 0.08 (24 hr)
salmon

422 rabbit 1000-1600
(MLD)

124 rat 1.9


Chronic Toxicity
Ref Species Dose Effect



292 warmblooded Change in conditioned reflexes;
animals change in blood serum com-
position

351 rabbit 0.5 and Decrease in blood catalase
5.0 mg/kg/ activity
day for
6 mos




-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

FORMALDEHYDE
HCHO

FURFURAL
W2
^CHO

METHYL ETHYLKETONE
CHjCOCjHj
MGK REPELLENT 11
-XX s^
I )
^So-T^
H. 0-CR
PIVAL
(PINDONE)
^ 'I 0 CH,
f^^^^. n i 3
L JL / C~C~CH3
II CH
0 J
Source

occurs in tannery
wastes, penicillin
wastes, and effluent
from manufacture of
plastics and resins

used in manufacture
of plastics, as a
solvent in petro-
leum refining, in the
manufacture of var-
nishes and as a
pesticide

solvent for resins,
nitro, and acetyl-
cellulose
pesticide (repellent)
pesticide

Acute Toxicity
Ref Specie:-, LD50 rag/kg 96 hr ,TLn LC50 mg/1
mg/1
ALDEHYDES AND K.ETONES
252 rat 800
channel cat 25
88 D. magna >100 <1000
(24 hr)
220 mouse 425
rat 126.7
252 dog 2300
200 guinea pig 541.7
435, mosquito 24
449 fish
252 bluegill 24
252 rat 3980
bluegill 5640
(48 M)
435 mosquito 5600
fish
340 rat 2500
124 rat 280

Chronic Toxicity
Ref Species Dose Effect

287 No significant effects on the
animals studies

220 rat 25 mg/kg/ No significant effect
day for
4 mos

442 warmblooded No significant effects
animals




-------
TABLE  III  (CONT.) -  ACUTE  AND CHRONIC  TOXICITY OF POTENTIAL  ORGANIC  POLLUTANTS
         Agent
  ANISOLE
  DIBROMOHEPTAFLUORO-
  ISOBUTYL METHYL ETHER
  CF
        BrCBrFOCH_
 DIETHYL ETHER

 CH3CH2-0-CH2CH


 DIMETHYLDIOXANE

 C6H12°2
                             Source
in waste waters  from
synthesis of analogs
and derivatives  of
DDT; trace amounts in
BKME waste

refrigerant, propel-
lent, fire extin-
guisher,  solvent
                                                               Acute Toxicity
                                             Ref   Species
                                       LD50 mg/kg   96 hr^TLm
                                                                          ETHERS
                                             283
106  rat
                                                               1150
                  1150
                                                                                                                      Chronic Toxicity
                                                                                                 Ref
                                                                                                        Species
                                                                                                                  Dose
                                                                                  Effect
                                                                                                 283
                                                                                                       rabbit
                                                                                                                  0.025 rag/kg  Change in blood sugar  curve
                                                                                                                  daily for
                                                                                                                  6 mos
                                                                               warmblood- 0.2  mg/kg
                                                                               ed animals daily
                                                                                 Ineffective dose during
                                                                                   sanitary toxicological  tests
                                                                         .93,
                                                                         .93

                                                                         192
                                                          labora-
                                                          tory
                                                          animals

                                                          rabbit
0.005 mg/kg  Does not affect functional
daily          condition
                                                                                                                 0.25 mg/kg
                                                                                                                 daily for
                                                                                                                 6 mos
                                                                                                      Decrease in hemoglobin concen-
                                                                                                        tration;  decrease  in blood
                                                                                                        sugar; change  in glycogenic
                                                                                                        liver function
                                                                                          0.0025       Change in rate of 03 consump-
                                                                                          mg/kg          tion; change in conditioned
                                                                                          daily for      reflexes
                                                                                          6 mos

-------
TABLE III (CONT.)  - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

EPICHLOROHYD'RIN
<**"
CH2 	 CHCH2C1












FATTY ACYL SORBITAN
EO (20)
0

FURAN
XO-x
f 1
\i — y
HEPTAFLUOROISOBUTY-
1ENE METHYL ETHER

CF3
CF/C"CF"°"CH3
Source

manufacture ot epoxy
res ins













surfactant


CH2CH20)20H
organosynthetic
industry


refrigerant, propel-
lent, fire extin-
guisher


Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLtn LC50 /x
ng/1
ETHERS
105 rat 141.1
mouse 194.6
guinea pig 280
rabbit 345











397 rat 20,000-60,000+

mouse 25,000+
hamster 18,000



106 rat 1070




Chronic Toxicity
Ref Species Dose Effect

105 rabbit 0.5 mg/kg Low concentration of reduced
daily for glutathione 15 days after
6 mos beginning of administration
and a higher concentration of
oxidized glutathione toward
the end; change in reticulo-
cyte number; decrease in
vitamin C in liver, kidneys,
and spleen
0.05 mg/kg Similar effects as above
daily for
6 mos
rat 0.005-5 Affected conditioned reflexes
mg/kg/day
0.005-5 Decreased synthesis of hippuric
mg/kg/day acid




343 rat 0.2-50 Liver damage from only the
mg/kg peripheral lobes at the lower
daily for dose to atrophic annular
3 mos cirrhosis at the higher dose






-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF  POTENTIAL ORGANIC  POLLUTANTS
Agent

HEXAFLUOROPROPYL
METHYL ETHER
CF3CHF-CF20-CH3
IAURYL ALCHOHOL EO
Source

refrigerant, propel-
lent, fire extin-
guisher
surfacant
CH3(CH2)10CH20(CH2CH20)n H
NEOTRAN
"OrO-
NONYL PHENOL EO
OCTAFLUOROISOBUTYL
METHYL ETHER
CF-
OCTYLPHENOL EO
(1-40)
pesticide

surfacant
refrigerant, propel-
lent, fire extin-
guisher, solvent

CflH17-^ Vo(CH CH.O). ,nH
OX/ \ / £. £ 1— 40
Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLm LC5Q mg/1
ETHERS
106 rat ~30,000
(IP)
397 mouse 1170-7600
rat 4150-9350
252 rat 5800
channel cat 21.8

397 rat 1600
06 mouse >1000
97 '«' 1800-28,000 +

Chronic Toxicity
Ref Species Doae Effect




252 rat 100 mg/kg No effect
in diet 50
days
3000 mg/kg Pronounced histo-pathology
in diet 50
days





-------
TABLE III (CONT.)  - ACUTE  AND CHRONIC  TOXICITY OF  POTENTIAL ORGANIC  POLLUTANTS
Agent

PERFLUOR01SOBUTENYL
ETHYL ETHER
X
JE-CF2-0-CH2CH3
CF3

PIPERONYL BUTOXIDE
OV.""^- CH2CH2CH3
Source

iraste product from
synthesis of fluorine
containing plastics

pesticide synercist
r\r*n ru n/*ru \ ru
Q^f^ CH2OCH2CH2l«.n2w.2U^..2,r..3
POLYETHYLENE-
CYCLOALKYL PHENYL
ETHERS
(OP-7, OP-10)
Alkyl-f y-0(CH2CH2
detergents
D) H
ROTENONE pesticide
OCH3
VvV^i
1 1 S ^9
I I c>^ *
Acute Toxicity
Ref Species LD50 mg/kg 96 hr .TLm LC50 mg/1
mg/1
ETHERS
364, mouse 164
370

124 rat 7500c'
61509
>7950 (dermal)
340 11,500


252 human 0.2 g/kg is fatal
34Q rat 132-1500
252 132
449 bluegill 0.024
252 fathead 0.006-0.066
catfish 0.47
449 rainbow trout 0.032
Chronic Toxiclty
Ref Specie* Dose Effect

364 rabbit 6 mg/kg Change in blood composition;
daily for decrease in prothrombln time;
7 mos affects glycogenic function
of liver
rat 6 mg/kg Decrease in 0. consumption
dally for weight loss, histological,
7 mos histochemical and neuro-
histological changes
0.15 mg/kg Decrease in conditioned
for 7 mos reflexes


132 rat 150 mg/kg Increase in weight of kidney
OP-10 daily fatty dystrophic liver
for 4 r.-,os changes
mouse 47. (400 No changes
mg/1) CP-
7 daily for
55-62 days
252 rat 5 mg/kg Necrosis of the liver
in diet
daily



-------
TABLE  III  (CONT.) -  ACUTE  AND  CHRONIC  TOXICITY OF POTENTIAL  ORGANIC  POLLUTANTS
        Agent
Source
                                                               Acute Toxicity
                Ref   Species    LD50 rag/kg  96 £r "a
                                                                                     LC50
                                                                                                                     Chronic Toxicity
                                                                                                Ref
                                                                                                       Species    Dose
             Effect
                                                                      ETHERS
 SAPONIN
                       industrial effluent;
                       charging  fire extin-
                       guishers; detergents
                                                                                                216
                                                                          rat        1,  10, and   Affected conditioned reflexes;
                                                                                     50  mg/kg       change in nerve cells
                                                                                     dally for
                                                                                     3-4 mos

                                                                                     10  and 50    Histologlcal changes in liver
                                                                                     mg/kg dally    and kidneys
                                                                                     for 4 mos
 STEARYL ALCOHOL EO
 STEROX
 TETRAHYDROFURAN
                       detergent
                                            397   rat
                174  silver
                    salmon
                                                              2900
                                                              25,000  +
                                                                         20 tug/1
                                                                         (80% kill:
                                                                             in*22 hrs)
                                            319  rat           2300

                                                mouse         3000

                                                guinea pig    2300
                                                                   320
                                                                                               319
                                                                         In^ls°ded >5-m8/1 ln   Path°l°8ical changes
                                                                                                      mouse,
                                                                                                      rat,
                                                                                                      rabbit
drinking
water daily
20 mg/kg
dally for
5-6 mos
                                                                                                                 10 mg/kg
                                                                                                                 daily for
                                                                                                                 5-6 mos
                                                                                                 Decrease  in conditioned reflexe
                                                                                                   increase in reticulocytes;
                                                                                                   decrease in cholinesterase
                                                                                                   activity; increase in liver
                                                                                                   glycogen
                                                                                                 Growth  impairment

-------
TABLE 111 (CONT.)  - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

BENZENE

NAPHTHALENE


PHENANTHRENE

t^y^r^
CJ[J
p-AMINOPHENOL
BENZOQUINONE
DIOXIME
HON=Q = NOH
Source

tar and gas waste,
dyeing and other
textile operations

tar and gas waste;
refinery textile mill
and other industrial
waste








Acute Toxicity
Ref Species LD50 mg/kg 96 hr Tim LC50 ^^
UNSUBSTITUTED AROMATICS
252 rat 5600
5700
174 sunfish 35-37
(lethal in
1 hr)
435 mosquito fish 386
124 rat 2000cT
24009
>2500 (dermal)
174 sunfish 4-5
(lethal in
1 hr)
perch 20-40
(lethal in
1 hr)
435 mosquito fish 150
333 mouse 700
174 sunfish 1-2
(lethal in
1 hr)

PHENOLS AND QUINONES

45 rat 1580
mouse 1420
Chronic Toxicity
Ref Species Dose Effect










410 rat 0.05 mg/kg Ineffective dose
daily for
7 mos


-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

CATECHOL -„
UC1
0^H
CHEREMKBOVSK
TAR - INTERMEDIATE
FRACTION
(high MH phenols 30%,
hydrocarbons 50%,
neutral oxycompounds
15%)
CHLOROPHENOL
DICHLONE
(PHYGON)


0
X^N-X^-Cl
L II H
0


Source




semi-coking of coal




petrochemical
pesticide









Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLm LC50 mg/1
mg/1
PHENOLS AND QUINONES
174 perch 20
(fatal in
1 hr)
211 mouse 1380




174 bluegill 8.1
252 rat 1500
coho salmon 0.42
(48 hrs)
channel cat 0.14
fathead 0.15
252, largemouth 0.07
449 bass (48 hrs)
252 rainbow trout 0.074
red-sided 0.011
shiner
Chronic Toxicity
Ref Species Dose Effect




2H guinea pig 100 mg/kg Loss of weight; increase in
daily for weight of adrenals; change
4 mos in electrocardiogram; change
glycemic curves
10 mg/kg Change in g lycemic curves
daily for
4 mos

252 human Skin irritation
rat 1580 mg/kg Retarded growth
in food








-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

DIMETHYIRESORCINOLS
(shale phenols)
DINITROCRESOL
(DNOC)
CHj^OH
2, 4-DINITROPHENOL

OH
rY N°2
Wx^
NO
DINOSEB
(DNBP) H c CH
NO"^C\H32 3
DIPHENYLOLPROPANE
. . . .
^ 32 ^64 2






Source

carbonization of oil
shales; production of
tanning compounds
pesticide


pesticide, production
of dyes




pesticide











Acute Toxicity
Ref Specieu LD50 mg/kg 96 hr TLo LC50 mg/1
mg/1
PHENOLS AND QUINONES
420 rat 1000

173 rat 25-40


316 rat 31.2
mouse 46.5
guinea pig 81.0
rabbit 30


173 rat 50











Chronic Toxicity
Ref Species Dose Effect

420 rat 100 mg/kg Decreased weight
daily for Affected kidneys and liver
20 wks



31° rat 0.031 and Decrease In conditioned re-
0.62 mg/kg flexes; changes In content
for 7 mos of urea; decrease in content
of high-energy phosphorus
compounds In the liver
rabbit 0.03 mg/kg Decrease in SH groups
for 7 mos



104 rat 0.25 mg/kg Change in acid resistance of
dally for erythrocytes ; decrease in
6 mos ascorbic acid concentrations;
Also affects: oxidation-
reduction processes , SH-groups
of reactive proteins, the
liver function, the neuro-
hormonal regulation and the
central nervous system

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent


GUAIACOL
CH,OC,H. OH
3 6 4 OH
HYDROQUINONE
C6H4(OH)2
OH
r^\
r j
OH
of. -NAPHTHOL


^«*^ .^-s^
CjCj
^!XOH
B- NAPHTHOL


r^Y^i
L II ^\
•^x^s*-' — OH





Source


tar and gas wastes,
component of BKME

anti-oxidant, as a
reducer in photo-
graphic development
and as a chemical
reagent in phosphate
tests

waste from dye and
insecticide industry;
also from plants en-
gaged in distillation
of bituminous coal

waste from dye and
insecticide Industry;
also from plants en-
gaged in distillation
of bituminous coal







Acute Toxicity
Ref Species LD50 mg/kg 96 hr ,TLn LC50 mg/1
mg/1

PHENOLS AND QUINONES
174 perch 70-80
(48 hr)

252 rat 320
goldfish 0.287
(48 hrs)



331, rat 2400
332 mouse 280

guinea pig 2000
rabbit 9000
cat 134
331, rat 1960
332 Q,
mouse 70
guinea pig 1335
rabbit 5400
252 3800

331 cat 89




Chronic Toxicity
Ref Species Dose Effect
i
i



271 warmblooded Considerable effect on bone
anima Is marrow









331 rat 4.4 mg/kg Changes in CNS function; change
daily for in conditioned reflexes; de-
8 mos crease in cholinesterase
activity
196.0 mg/kg Decrease in cholinesterase
/day for activity; Increase in pro-
8 mos thrombln time; decrease in SH
groups; decrease in phagocytic
activity of leucocytes
12.0 mg/kg Change in glycogenic function
/day for of liver
8 mos

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent
1, 4-NAPHTHOQUiNONE
NITROPHENOL (5
02y-\ y-OH

NITROTOLUOL
v-Q--
PYROGALLOL
OH
rT OH
QUINONE
6
0
ROSOLIC ACID
JJ^
^1
°H\>C -/°H
Source




used in dyeing of
woolens, & furs, for
staining leather, and
as a developer in
photography
used in photography,
dye manufacture,
tanning, and as an
oxidizing agent
tar and gas waste


1
Acute Toxicity
Ref Species LD50 ng/kg 96 hr run LC5Q fflg/1
PHENOLS AND qUINONES
*°0 2000 (lethal)
236 laboratory 328
animals
449 bluegill 46.3
(48 hrs)
204 rat 2400
mouse 330
rabbit 2400
252 dog 25
goldfish 18
(48 hr)
252 rat 130
50 perch 100
(lethal in
1 hr)

Chronic Toxicity
Ref Species Dose Effect

236 varmblooded Alterations in functional state
anlmal8 of organism

i
215 rat 120 mg/kg Increase in number of leuco-
daily cytes, and methemoglobln
blood levels; decrease in
erythrocytes and hemoglobin
level; affects liver ;raised
prothrombin index







-------
TABLE III (CONT.)  - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

TETRACHLOROCATECHOL
OH

Ctfi^rOH
0jJL .jjJLci
Cl
VETLUZHSK OIL
(25-37% high MH
phenols & esters, 10-
15% aromatic acids,
10-15% fatty acids,
20% hydrocarbons)





HALOGENATED
m-CHLOROANILINE

NH.

Ill
U ^ji
^-^ Cl

p-CHLOROANILINE
Nh.
0
Cl
Source

possible component of
Kraft pulp mill
bleach waste



wood resin
distillation; used as
a flotoreagent in con
centratlng iron ore
of low magnetic con-
tent






agricultural and
chemical effluent






agricultural and
chemical effluent


Acute Toxlcity
Ref Species LD50 ng/kg 96 hr TLm LC50 mg/1
ng/1
PHENOLS AND QUINONES
362 fish sub- lethal concentrations caused
an increase in rate of respiration
which was thought to indicate
disruption of cellular processes
by uncoupled oxldative phosphory-
lation
111 mouse 624-2850





AROMATIC DERIVATIVES

186 rat 1084 9
880 rf
230 256
136 mouse 1100
230 368

186 guinea pig 750
230 25°
186 rat 370 9
300 rf
mouse 400

Chronic Toxicity
Ref Species Dose Effect







111 guinea pig 100 mg/kg Decrease in 0. consumption;
daily adrenal hypertrophy shifts
in form of shortened B-P
intervals and changes in
QRST complex revealed by
electrocardiograms; histolog-
ical changes in liver and
kidneys
10 and 100 Effect on glycogen synthesizing
mg/kg daily function of the liver
for 4 mos


230, rat: 25 mg/kg Decrease in hemoglobin &
"' daily for erythrocytes ; increase in
8 mos reticulocytes; decrease in
liver glycogen; change in
CNS; histological changes in
liver and kidney; increase in
vitamin C content of
suprarenals.
186 guinea pig 5 mg/kg Glycogenic malfunction of the
daily for liver; decrease in phagocytic
7 mos activity of leucocytes


-------
TABLE  III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

p-CHLOROANILINE (cont!

2, 5-DICHLOROANILINE
aT^
3, 4-DICHLOROANILINE
^y^ Cl
Cl
DICHLOROBENZENE
DICOFOL
(KELTHANE)
C1-C-C1
|
OH
Source






insulator, plasti-
cizer, pesticide
pesticide

Acute Toxicity
Ref Species LD50 mg/kg 96 hr TUn LC50 «g/l
ng/l
AROMATIC DERIVATIVES
186 guinea pig 350

347 rat 3000
mouse 2500
guinea pig 3750
rabbit 3750
347 rat 700
mouse 1000
guinea pig 6750
rabbit 675
340 rat 500-5500
252 rat 575-1100
124 1100 cf
1000 9
1230 rf ) , . ,.
1000 9 ) (derraal)
173 575->2000
Chronic Toxicity
Ref Species Dose Effect

ISA
guinea 0.5 and 5 Protein dystrophy in liver
pig mg/kg daily
for 8 mos
rat 0.1 mg/kg Disturbance of conditioned
daily for reflexes
8 mos
3*7 rat 20 mg/kg Changes in conditioned reflexes,
daily for kidney and liver function and
6 mos blood concentrations

347 rat 20 mg/kg Changes in conditioned reflexes,
daily for kidney and liver function
6 mos and blood concentrations
143 rat 0.003 mg/kg No significant effects
daily for
5 mos



-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

DIIAN R
1
H- C -N02
H

ERBON
(BARON)
clHp_0_CH2-CH2_0-
Cl
HEXACHLOROBENZENE
Cl
"V*1
METHOXYCHLOR
ci-c-ci
i
Cl
Source

pesticide



0 Cl
II 1
C-C-CH3
Cl


pesticide
3
Acute Toxicity
Ref Species LD50 mg/kg 96 hr *Lm LC50 mg/1
AROMATIC DERIVATIVES
124 rat 600 rf
475 9
>3000 (undiluted
technical
grade)
173 475-4000
174 channelcat <0.5
449 chinook 2.3
salmon (48 hrs)
174 channelcat 6.9
(48 hrs)


252 human 350,000 (fatal to 70 g man)
293 rat 6000
252 5000-7000
bobwhite 22,000
quail
ring neck 25,000
pheasant
101 fathead 0.064
449 0.031
Chronic Toxicity
Ref Species Dose Effect






143 rat 0.005 mg/kg Changes in conditioned reflexes
daily for
4 mos

252 quail 1000 mg/kg 407= reduction in reproduction
in diet


-------
     TABLE  III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent


METHOXYCHLOR (cont)







PERTHANE
H
I
Source










pesticide

C1-C-C1
— .
H5C2 -f^y C -^_J)-C2H5
"
TETRACHLOROBENZENE
r V1
crV
1
Cl










pesticide; intermedi-
ate product in the
manufacture of the
effective fungicide
copper trichlorophen-
olate










Acute Toxicity
Ref Species LD50 mg/kg 96 hr ,TLm LC50 rag/1
mg/1
AROMATIC DERIVATIVES


101, bluegill 0.062
}?* 0.020
449
101 goldfish 0.056
174 guppies 0. 120
rainbow trout 0.05
(24 hr)
124 rat >4000
340 8170
252 8200
8500
449 bluegill 0.021
rainbow trout 0.009
108 rat 1500
mouse 1035 (in oil)
2650 (in starch)
rabbit 1500










Chronic Toxicity
Ref Species Dose Effect






i







i

108 rat 0.005 mg/kg Change in conditioned reflexes;
daily for increase in weight coeffi-
8 mos cients of the liver; decrease
in SH groups
0.05 mg/kg Increase in ascorbic acid con-
daily for tent of organs
8 mos
rabbit 0.05 mg/kg Disorders of glycogen function
daily for of the liver; increase in SH
8 mos groups in blood serum follow-
ed by a decrease; increase in
hemoglobin content of blood;
increase in content of
reticulocytes in the peripher-
al blood
8
o

-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

TETRACHLOROBENZENE
(cont.)
TRICHLOROBENZENE
Cl
C1
NITRO COMPOUNDS
p-DINITROBENZENE
°2N^)-N02
DINITROTOLUENE
(DINITROTOLUOL)
CJ"c*3
NITROBENZENE 2
C6H5N02
XYLENE
C6H4(CH3)2
Source


insulator, plasti-
cizer, synthesis of
some explosives



aniline dye and other
industries

manufacture of
aniline, soaps, and
shoe polishes
solvent and cleaning
agent; manufacture of
dyes and organics
Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLm LC5Q fi
mg/1
AROMATIC DERIVATIVES



252 rat 29.4



252 rabbit 700

252 rat 4300
124 sunfish 47-48 (lethal
in 1 hr)
88 D. Magna >100
<1000
(48 hrs)
Chronic Toxicity
Ref Species Dose Effect

108 rabbit 0.005 mg/kg Disorder of glycogen function
daily for of liver; change in content
8 mos of SH groups in serum in
last month of experiment
255 rat 0.01 mg/kg Increase in eosinophiles,
daily for reticulocytes, and leucocytes
5.5 mos in the blood; reduced 0-
consumption
143 0.003 mg/kg Did not affect conditioned
daily for reflexes
7-8 mos


126 rabbit 0.5 and 0.05 Histological changes in liver
mg/kg daily
for 8 mos



rat 4 and 48 Occasional variation in hemo-
mg/kg daily glob in, erythrocytes , and
for 5 1/2 mos leucocytes; marked eosino-
philia; change in reticulocyte
number
4S mg/kg Lymphopenia
daily for
5 1/2 mos

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

ARYIALKANES
ETHYL BENZENE
f, — ^

-------
TABLE III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

BUTYL XANTHOGENATE
i__
25~~2223
CARBON DISULFIDE
cs2

DIMETHYLSULFIDE
DIMETHYLSULFOX1DE
0
II
CH.J-S-CH-

METHYL MERCAPTAN
CHjSH
Source

f lotoreagent



waste from production
of cellulose by
sulfate method


bleached Kraft pulp
mill effluent
Acute Toxicity
Ref Species LD50 mg/kg 96 *>r TLm LC50 mg/1
MERCAPTANS AND OTHER SULFUR ORGANICS
234 mouse & rat 600-800

'<35mosquito fish 13.5

201 rat 3300
mouse 3700
2Q1 Chinook 12,000
salmon
sockeye 13,000
salmon
coho salmon 16,000
rainbow trout 17,000

Chronic Toxicity
Ref Species Dose Effect

, ?' rat 1 mg/kg Decrease in blood prothrombin,
daily for histopathological changes in
4 mos liver and kidneys
233 10 mg/kg Change in conditioned reflexes
daily for
4 mos
rabbit 70 mg/kg Change in phagocytic activity;
daily for change in carbohydrate
6 mos metabolism
201 rat & 15 mg/kg Decrease in rate of weight gain
rabbit daily for in rabbit only; decrease in
7 1/2 mos cholinesterase activity; de-
crease in blood

201 fish high concen- Change in number of various
tration or blood components; histopatho-
over a long logical change in liver,
period of kidney, brain, gills, and
time spleen

449 fish 1 mg/1 Restlessness, a progressive
respiratory depression,
muscular weakness, convul-
sions, spastic paralysis

-------
    TABLE III (CONTJ  - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent
MUSTARD GAS
ClCHjCHjSC^CHjCl
PHOSTEX
CH3CH20
O^O--*-8-8-'-
SULFOXIDE
f^f^°
^JJ 0
CH3
TH10FHENE
A
I! 	 u
D1ETHYIMERCURY


Source
chemical warfare
agent
pesticide
„ OCH2CH3
-OCH 	 CHj
synergist

organosynthetic
industry, tar and
gas waste

effluent from syn-
thesis of ethyl
mercuric chloride and
phosphate


Acute Toxicity
Ref Species LD50 mg/kg 96 ht ,TLn LC50 mg/1
rag/1
MERCAPTANS AND OTHER SULFUR ORGANICS
252 rabbit 500 mg/1 causes gastrointestinal
inflammation
guppy 20 mg/1 fatal in 15 min
124 rat 350 
340 rat 500-5000

174 sunflsh 27
(fatal in
1 hr)
ORGANOMETALICS
458 rat 51.2


Chronic Toxicity
Ref Species Dose Effect



343 rat 10 mg/kg Change In conditioned reflex*
daily for
4 mos.

458 rabbit 0.0005- Decrease in blood serum SH
0.005 mg/kg groups in rabbits; distur-
daily for bance in liver parenchyma
6 mos
rat 0.000005- Higher doses disturbed catalase
0.00005 mg/ activity; higher dose affectec
kg daily for conditioned reflexes
6 mos
rat & 0.005 mg/kg Histopathological changes in
rabbit daily for liver and kidneys
6 mos
*
*•

-------
     TABl£  III (CONT.) - ACUTE AND  CHRONIC TOXICITY OF POTENTIAL ORGANIC  POLLUTANTS
Agent

ETHYLMERCURIC
CHLORIDE
CH3CH2HgCl


TETRAETHYL LEAD
Pb(C2H5)4
TETRAETHYL TIN
Sn(02H5)4

BUTOXY POLYPROPYLENE
OLYCOL
(CRAG FLY REPELLENT,
OPS-B)
CAH90(CH2CHO)nH
CH3
Source




effluent from crude
oil distillation
plants


pesticide, flotore-
agent
Acute Toxicity
Ref Species LD50 mg/kg 96 hr TLn LC50 mg/1
mg/1
ORGANOMETALLICS
458 vat 211.8


449 bluegill 0.20
371 rat 15.9
mouse 39.8
guinea pig 37
rabbit 7
POLYMERS
340 rat 9100-11,200
49 17,000
Chronic Toxicity
Ref Species Dose Effect

458 rabbit 0.0005- Decrease in blood serum SH
0.005 mg/kg groups
dally for
6 mos
rat 0.000005- Higher dose affects conditioned
0.00005 mg reflexes
/kg dally
for 6 mos
rat & 0.005 mg/kg Histopathological changes In
rabbit /day for liver and kidneys
6 mos

373 rat & 0.0001 mg/ Decrease in hemoglobin; de-
guinea pig kg daily crease in erythrocyte count;
for 7-9 mos decrease in cholinesterase
activity; increased leucocyte
count; change in kidney
function; change in condition-
ed reflexes

308 rat 400 mg/kg Change in cholinesterase
daily for activity
6 mos
7 -400 mg/kg Change in conditioned reflexes
daily for
6 mos
*
UI

-------
TABLE  III  (CONT.) -  ACUTE  AND  CHRONIC  TOXICITY  OF  POTENTIAL ORGANIC  POLLUTANTS
        Agent
                             Source
                                                               Acute Toxicity
                                             Ref   Species     LD50 mg/kg
                                                                                                                      Chronic Toxicity
                                                                                                 Ref    Species   Dose
                                                                                                        Effect
                                                                         POLYMERS
 METHOXYPOIYPROPYLENE
 GLYCOI.

   (OPS-M)
 METHYL SILICONATE
 POLY(ETHYLHYDRO-
 SILOXANE
 POLYMETHACRYLATE,
 cationic
    (VA-102)
 POLYSTYRENE,
 cationic

    (VA-2,  VA-3)
 ACTUSOL
flotoreagent
                                            212  mouse
                                                               3900
water repellent
used for purification
of vater
flocculant for water
purification
425  laboratory    1500-3000
     animals
                       oil diapersant
                     407  fingerling
                          steelhead
                         SURFACTANTS
                      (structure unknown)

                             24.0
                                                                         308    rat
                                                                                                308
                                                                                                       guinea
                                                                                                       Pig
                                                                         308    rat
                                                     08
                                                           rat
425    rat
                                                                      2.5  mg/kg
                                                                      daily  for
                                                                      6 mos
                                                                                           25 mg/kg
                                                                                           dally for
                                                                                           6 HOB
                                                                                                       Change in conditioned reflexes;
                                                                                                        change in cholines(erase
                                                                                                        activity
                                                                                  Slight protein dlstrophy  in
                                                                                   liver and kidneys
                                                                                           £80 g/kg     no toxic effect
                                                                      1 g/kg
                                                                      daily for
                                                                      30 days
                 0.1 mg/kg
                 daily for
                 10 mos
                             Decrease in CNS;  change in
                               vegetative nervous  system
Slight change  in conditioned
  reflexes;change in stomach
  histology; increase in
  eosinophiles

-------
TABLE III (CONT.) - ACUTE AND CHRONIC TOXICITY OF POTENTIAL ORGANIC POLLUTANTS
Agent

BUST
CHEVRON NI-0
COREXIT-7664
E-314
F. 0. 300B
GAMLEN-CW
HOLL-CHEM 662
JAN-SOLV-60
PETROLITE
W-1439
POLYCOMPLEX
A-ll
SEASWEEP
Source

detergent
oil dlspersant
oil dlspersant
oil dlspersant
oil dispersant
used to precipitate
paint from the sur-
face of water
oil dispersant
oil dispersant
oil dispersant
oil disperaant
oil dlspersant
Acute Toxiclty
Ref Species LD50 rag/kg 96 hr TLm LC5Q ^
ng/1
SURFACTANTS
(Structure unknown)
407 finger ling 3.2
steelhead
407 fingerling 15.8
steelhead
407 fingerling 22.5
steelhead
407 fingerling 65.0
steelhead
174 Chinook 10-17.8
salmon (critical
level)
407 fingerling 3.2
steelhead
407 fingerling 35.5
steelhead
407 fingerling 35.5
steelhead
407 fingerling 13.0
steelhead
407 fingerling 20.2
steelhead
Chronic Toxicity
Ref Species Dose Effect

17* fish high con- Fatal due to alkalinity of
centration solutions; exhibited symptoms
of distress, and at death
were excessively slimy with
opaque corneas




!74 fish Irritation and intoxication,
including spasmodic snapping
of the jaws, violent activity
and twitching of eyes and
fins






-------
      TABLE  III (CONT.)  -  ACUTE  AND CHRONIC TOXICITY  OF  POTENTIAL ORGANIC  POLLUTANTS
              Agent
                                  Source
                                                                    Acute Toxlcity
                                           Ref   Species     LD50 mg/kg  96 hr Tim
                                          _                            mg/1
                                                                                                 fi
                                                                                                                   Chronic Toxlcity
                                                    Ref   Species    Dose
                                                                                                                                   Effect
        SPILL-X
B
oo
ALGIBIOL

C 56



MEZIDINE
        SHELL D50

        SORICIDE TETRAMINOL
                              oil dispersant
                              pesticide

                              pesticide
                             aniline dye inter-
                             mediate
                      pesticide

                      pesticide
                                                                   SURFACTANTS
                                                               (Structure unknown)
                                          407   fingerling    35.5
                                                steelhead
251  fathead

174  bluegill

     largemouth bass
174  rainbow trout

251  fathead
     ORGANICS

(Structure Unknown)

      20 (24 hrs)

      30 (48 hrs)

      35 (48 hrs)
      210 (48 hrs)

      8 (48 hrs)
                                                                                                     28
                                                                                                               small doses  Changes of the  hemopioetic
                                                                                                                             and nervous systems and
                                                                                                                             hepatic functions, oxidative
                                                                                                                             and tropic processes of the
                                                                                                                             body

-------
T-ABLE IV - CONCENTRATION AND  EFFECTS  OF  ORGANIC  POLLUTANTS  IN HUMAN AND
                           ANIMAL  TISSUE
     This table  contains available  information on chemicals  the
     concentrations and effects  of  which have been examined  in
     tissues.  It will be noted  that  all information contained in
     this table  refers to  pesticides.   The data indicates that
     pesticides  can be stored  in the  tissues  of humans normally
     exposed  to  pesticides  and  deaths  have occurred as a result
     of  accidental exposure  which have  resulted in high  concentra-
     tions  in tissue.  In some instances sequential information
     was examined and shows  that some pesticides had increasing
     concentrations with time  in the  US and in India, but not in
     England  or  in some cases  in France.  Information on animal
     tissues  shows extremely high tissue concentrations in animals
     living in highly pesticide-treated areas while aquatic  life
     generally indicate low  concentrations as compared to man and
     terrestrial animals.

-------
        TABLE IV - CONCENTRATION AND EFFECTS OF ORGANIC POLLUTANTS IN HUMAN AND ANIMAL TISSUE
        Ref
                   Agent
 Species
                Halogenated^

          83     BENZENE HEXA-
                CHLORIDE
         84
 man
ho
4s
vo
       315
       337
        71     CHLORDANE
fish (50 na-
tionwide sampling
stations)
                                                            Dose or Exposure
                                                      ALKANES  AND ALKENES
                     normal exposure to pesticides
                     during life

                     France

                     US

                     normal exposure to pesti-
                     cides
us
England
France
India
1961-62
1962-63
1964
1963-64
1964
1961
1964
                                                     normal exposure to pesticides
accidental contamination of seed
grain (Turkey)

normal exposure
                                                                                                     Effect
                                                                                            stored

                                                                                            stored  (< France)
0.20 ppm in body fat
0.57 " " "
0.60 "
0.42 "
0.02 " "
1.19 " "
1.43 "
11 it
11 it
ii it
n ii
ii ii
pregnant women: mean concentra-
tion in fat tissue 0.14 ppm
 "   "  blood "    0.0045 "

non-pregnant women: mean concen-
tration in blood tissue: 0.42ppm

fetus "     "      "  0.0012 ppm

>3000 cases, 3-11% deaths (an-
nually in different years)

storage in 22% of 590 samples

-------
      TABLE. iv.,(CQNi.) — CONCENTRATION  AND  EFFECTS  OF  ORGANIC POLLUTANTS IN HUMAN AND ANIMAL TISSUE
     Ref
Agent
Species
Dose or Exposure
                                                                                  Effect
             Halogenated
       91    DIELDRIN
              human
to
<_n
O
       83
                                                    ALKANES AND ALKENES
                normal exposure to pesticides
                               in various  locations
                               US (3 cities)
                               US (4 cities)
                               India
                               New Orleans
                               England, Wales
                               England
                               Chicago
                               Toronto, Canada
                               Miami
                               normal exposure  to  pesticides
                               England
                               US
                               normal exposure  to  pesticides
                               US   1961-62
                                    1962-63
                                    1964
                                    1964
                             storage in adipose tissue
                             0-5 years (white)
                             range: < .05-.73 ppm (mean 0.23)
                             6+ years (white)
                             range: <-05-.77 ppm (mean 0.23)
                             0-5 years (nonwhite)
                             range: <.05-.46 (mean .21)
                             6+ years (nonwhite)
                             range: <.05-.43 (mean .20)
                             storage in adipose tissue
                             range  .02-.36 ppm  mean .15 ppm
                                    .07-2.82 "    "   .31 "
                             <  .02-.36
                                .03-1.15     "    "
                             <  .10-.90
                                .10-.73
                                .01-1.39
                                .07-.53
                             <  .05-.77
                             storage in fat
                             0.21 ppm (mean)
                             0.15 ppm (mean)
                             storage
                             0.15 ppm in body fat
                             0.11   "  	
                             0.31   "  "    "   "
                             0.29   	   "
                                                                               .03 "
                                                                               .29 "
                                                                               .26 "
                                                                               .22 "
                                                                               .14 "
                                                                               .22 "
                                                                               .22 "
                                                Denmark 1965
                                                                      0.20

-------
        TABLE IV (CONT.) -CONCENTRATION AND  EFFECTS  OF  ORGANIC POLLUTANTS  IN HUMAN AND ANIMAL TISSUE
        Ref
Agent
Species
Dose or Exposure
Effect
                                                       ALKANES AND ALKENES
               DIELDRIN

               (continued)
               human
         84
        315
Cn
         50
                normal exposure to pesticides

                England 1961-62
                        1963-64
                        1964

                India   1964
                Italy   1965

                general population, male,  US, 1965
                   ti      it          ii    ii    ii

                                  female  "

                                  England, 1964

                occupational exposure, 1964

                normal exposure to pesticides
                               normal  exposure  to  pesticides  during
                               life  (range:  28  weeks  gestation  to
                               88  years  of age)
                             storage

                             0.21 ppm in body fat
                             0.26   "  "
                             0.21   "  "

                             0.04   "  "   "
                             0.59   "  "   "   "

                             0.0014 ppm in whole blood
                             0.0019  "  "  plasma

                             0.0013  "  "  serum

                             0.0014  "  "  whole blood

                             0.0463  "  "

                             storage

                             pregnant women: mean cone,  in
                             fat tissue:  0.08 ppm
                             mean cone,  in blood: 0.0016 ppm

                             nonpregnant women:  mean cone,  in
                             blood: 0.17 ppm

                             fetus: mean cone,  in blood: 0.0013
                             ppm

                             44 autopsies provided following
                             mean values:
                                                                                        perirenal  fat: 0.0300 ppm of whole
                                                                                                                     tissue
                                                                                                        0.0630 "   "   "
                                                                                                        0.0270 "
                                                                                                        0.0620 "   "   "
                                                                                                        0.0190 "   "   "
                                                                                                        0.0060 "   "   "
                                                                                                        0.0056 "   "   "
                                                                                                        0.0037 "   "   "
                                                                                                        0.0031 "
                                                                                                        0.0021 "
                                                                     mesenteric  fat
                                                                     panniculus  fat
                                                                     bone  marrow:
                                                                     TBLN*:
                                                                     adrenal
                                                                     kidney
                                                                     liver
                                                                     brain
                                                                     gonad
                                                                                        * tracheo bronchial lymph nodes

-------
   TABLE, IV  (C.QNT.1  - CONCENTRATION AND  EFFECTS  OF ORGAiNlC POLLUTAiVTS  IN HUMAN AND  ANIMAL TISSUE
   Ref
Agent
Species
Dose or Exposure
                                                                                                 Effect
           DIELDRIN

           (continued)
    337
    125
Ui
to
    334
     71
    337
               human
               fish
                 bluegills
                 redears
                 goldfish
                 white cat-
                 fish
               eagles
                fish  from  50
                nationwide
                sampling
                stations

                fish
                        ALKANES AND ALKENES

                normal  exposure  to pesticides during
                life  (continued)


                0;  0.05;  0.211 mg/man/day  for two
                years (<,  0.0028-0.0036 mg/kg/day)
                 sublethal concentration followed
                 by  recovery period (up  to 41 days)
                 normal exposure to pesticides
                 normal exposure to pesticides
                 poor handling  in sandfly con-
                 trol (Wisconsin or boundary
                 waters)
                                                                                     lung:
0.0022 ppm of whole
             tissue
0.0021  "  "
                             spleen:
                             only difference was increased con-
                             centration of dieldrin in  adipose
                             tissue, blood

                             stored  in all tissues in varying
                             amounts

                             liver          )
                             gall bladder  )   high concen-
                             pyloric caeca  )   trations
                             intestine      )
                                                                                     muscle
                                                                                         low concentration
                              storage
                              bald eagles:  carcass:(median value)
                                           1965         1964
                                           0.33 ppm    0.65 ppm
                                           liver:
                                           0.21  "     0.35  "
                                           brain:
                                           0.08  "     0.10  "

                              gold eagles:  carcass:  1964-65 0.09
                                                            ppm
                                           liver      " threshold
                                           brain      "   "

                              storage in 75% of 590 samples
                                                     U 1.94)
                              range: trace 12.5 ppm of whole fish
                                       n i ro         II   II    II
                              average:  0.158 ppm

-------
    TABLE. IV (CQNI.) -  CONCENTRATION AND EFFECTS OF ORGANIC  POLLUTANTS IN HUMAN AND ANIMAL TISSUE
    Ref
    Agent
Species
Dose or Exposure
Effect
                                                   ALKANES AND ALKENES
    140    DIELDRIN
           (continued)
     84    ENDRIN
                 hen pheasants
                 man
    334
     50
                 bald eagle
HEPTACHLOR-
EPOXIDE
                            man
ro
Ul
to
                  4 mg/week
                  normal exposure to pesticides
                  US    1964
                        1964
                  England 1964
                  Italy 1965

                  normal exposure 1965
                  from normal exposure to pesti-
                  cides during life (range 28
                  weeks gestation to 88 years
                  of age)
                             average: 41.2 ppm in fat
                             had no adverse effect on feeding,
                             weight or egg production

                             storage
                             < 0.02 ppm in body fat
                             < 0.03  "  "   "
                             < 0.02  "  "
                             0.93    "  "   "

                             carcass (median value) 0.09 ppm
                             liver                  0.09  "
                             brain       "   threshold

                             44 autopsies provided following
                             mean values:
                             perirenal fat  0.0220 ppm of whole
                                                          tissue
                             mesenteric fat 0.0320  "  "
                             panniculus fat 0.0270  "  "    "
                             bone marrow    0.0040  "  "    "
                                                                                     TBLN*
                                                                                     adrenal
                                                                                     kidney
                                                                                     liver
                                                                                     brain
                                                                                     gonad
                                                                                     lung
                                                                                     spleen
                                                                                         0.0001
                                                                                         0.0012
                                                                                         0.0009
                                                                                         0.0019
                                                                                         0.0002
                                                                                         0.0001
                                                                                         0.0003
                                                                                         trace
                                                                                     * tracheobronchial lymph nodes

-------
TABLE IV  (CQNT.) -CONCENTRATION AND EFFECTS OF ORGANIC POLLUTANTS IN HUMAN AND ANIMAL TISSUE
Ref
   Agent
Species
       Dose  or Exposure
            Effect
                                             ALKANES AND ALKENES
  84
 334
  71
       HEPTACHLOR-
       EPOXIDE
       (continued)
                  man
HEPTACHLOR
and/or
HEPTACHLOR
EPOXIDE
                  bald eagle
                          golden  eagle
fish from 50
nationwide
sampling
stations
                  normal  exposure  to pesticides

                  US   1964
                       1964
                  England 1963-64
                          1964

                  normal  exposure  to pesticides

                  general population, male
                  US   1965
                  general population, male
                  US   1965
                  general population, female
                  US  1965

                  normal  exposure
normal exposure to pesticides
                                     storage
                                     0.10 ppm  in body fat
                                     0.24   "   "   "   "
                                                                         < 0.1 "
                                                                         < 0.01"

                                                                         storage
                                                                                 0.0008 ppm in whole blood
                                                                                 0.0011
                                                                                       plasma
0.0008  "  "  serum

        (median value)
            1965         1964
carcass  0.06 ppm    0.09 ppm
liver  threshold     0.15 ppm
brain      "         0.10 ppm

carcass (median value)
         1964-65  threshold
liver
brain

storage - found in 32% of (590)
samples

-------
       TABLE IV  (CQNT.) -  CONCENTRATION AND EFFECTS OF ORGANIC POLLUTANTS IN HUMAN AND ANIMAL TISSUE
       Ref
         Agent
  Species
        Dose or Exposure
            Effect
                                                     ALKANES AND ALKENES
        125     LINDANE
                       fish
                    sublethal concentration followed
                    by recovery period (up to 41
                    days)
r-o
Ui
Ln
         71
50    DDD
fish (50 nation-
wide sampling
stations

human
                                           normal exposure
normal exposure to pesticides
(28 weeks gestation to 88 yrs.)
                                                                                         storage
                                                                                         visceral  fat  -  concentration
                                                                                         greatly exceeded those  of  any
                                                                                         other  tissue
                                                                                         liver          )
                                                                                         gall bladder   )
                                                                                         pyloric caeca  )
                                                                                         intestine     )
                                                                                                   high con-
                                                                                                   centration
                                     muscle - low concentration
                                     storage in 16% of 590 samples
                                     (< 0.1 ppm)
44 autopsies (whole tissue basis)
                                                                                         perirenal  fat
                                                                                         mesenteric fat
                                                                                         panniculus fat
                                                                                         bone marrow
                                                                                         tracheobronchial
                                                                                         lymph nodes
                                                                                         adrenal
                                                                                         kidney
                                                                                         liver
                                                                                         brain
                                                                                         gonad
                                                                                         lung
                                                                                         spleen
                                                                                                    0.0110 ppm
                                                                                                    0.0470  "
                                                                                                    0.0180  "
                                                                                                    0.0760  "

                                                                                                    0.0100  "
                                                                                                    0.0570  "
                                                                                                    0.0022  "
                                                                                                    0.326   "
                                                                                                    0.0020  "
                                                                                                    0.0015  "
                                                                                                    0.0009  "
                                                                                                    0.0031  "

-------
    TABLE IV  (CQN.T.1 -   CONCENTRATION AND EFFECTS OF ORGANIC POLLUTANTS IN HUMAN AND ANIMAL TISSUE
    Ref
 Agent
Species
Dose or Exposure
Effect
      50
Halogenated
DDE
                            human
      83
NJ
     334
               bald  eagles
                             golden eagles
                   AROMATIC DERIVATIVES

                  normal  exposure  to pesticides
                  (28 weeks  gestation  to  88  yrs.)
                   normal  exposure  to pesticides;
                   ordinary  dietary habits

                   appreciable environmental  ex-
                   posure  to pesticides  from  drift
                   from fields and  orchards

                   moderate  occupational exposure
                   extensive occupational exposure

                   normal  exposure  to pesticides
                             44 autopsies  (whole tissue basis)
                                                                                      perirenal  fat
                                                                                      mesenteric fat
                                                                                      panniculus fat
                                                                                      bone marrow
                                                                                      tracheobronchial
                                                                                      lymph nodes
                                                                                      adrenal
                                                                                      kidney
                                                                                      liver
                                                                                      brain
                                                                                      gonad
                                                                                      lung
                                                                                      spleen
                                                                                            4.64 ppm
                                                                                            4.40  "
                                                                                            4.48  "
                                                                                            2.08  "

                                                                                            1.38  "
                                                                                            0.875 "
                                                                                            0.209 "
                                                                                            0.200 "
                                                                                            0.0831"
                                                                                            0.0688"
                                                                                            0.0585"
                                                                                            0.0305"
                                                                       fat     6.1 ppm  (average) no adverse
                                                                                                effects

                                                                       fat     8.6  "
fat
fat
carcass
liver
brain
carcass
liver
brain
19.0 ppm "
434 ppm "
1965
8.90 ppm
4.91 "
1.37 "
0.49 "
0.33 "
0.10 "
ii
M
1964
7 . 80 ppm
5.15 "
1.00 "
(1964-65)
11
11

-------
        TABLE. IV (CQNT.)- - CONCENTRATION AND EFFECTS OF ORGANIC POLLUTANTS IN HUMAN AND ANIMAL TISSUE



        Ref	Agent	
  Species
        Dose or Exposure
             Effect
        83     DDT
human
        84
KJ
Ln
        315
        63
        50
                                                     AROMATIC  DERIVATIVES
3.5 mg/man/day for 21 mos.
                                                    35 mg/man/day for 21 mos.
storage of increasing amounts of
DDE, excretion of increasing
amounts of DDA; steady state
achieved and maintained until
dosage stopped, excretion dropped
off

same as for 3.5; excretion de-
creased very slowly after dosage
stopped and higher than controls
after 27 mos.
                    0.041 mg/day meat abstainers 1958   2.3 ppm
                    0.164 mg/day - general population
                                                 1954
                    0.202 mg/day - prison volunteers
                                                 1956
                    normal exposure pregnant women
                                 nonpregnant woman
                                 fetus

                    normal exposure
                    US  1961-62
                    France 1962-63
                    India 1964 (Delhi area, civilians)
                    India (other cities - military)

                    normal exposure to pesticides  (28
                    weeks gestation to 88 yrs.)
                                    4.9 ppm

                                    7.4 ppm
                                    fat 12.6 ppm, blood 0.0183 ppm
                                    fat 13.7 ppm
                                    blood 0.0081 ppm


                                    6.7 ppm
                                    8.8 ppm
                                    27.2ppm
                                    11.8ppm

                                    44 autopsies (whole tissue basis)
                                                                                        perirenal fat
                                                                                        mesenteric fat
                                                                                        panniculus fat
                                                                                        bone marrow
                                                                                        tracheobronchial
                                                                                        lymph nodes
                                                                                        adrenal
                                                                              1.33 ppm
                                                                              1.35  "
                                                                              1.16  "
                                                                              0.411 "

                                                                              0.892 "
                                                                              0.125 "

-------
       TABLE IV (CONT.) -  CONCENTRATION AND EFFECTS OF ORGANIC POLLUTANTS IN HUMAN AND ANIMAL TISSUE
       Ref
Agent
Species
Dose or Exposure
                                                                                                    Effect
              DDT  (continued)  human
         73
Ul
00
        437
                                   AROMATIC DERIVATIVES

                                 normal  exposure  to  pesticides  (28
                                 weeks gestation  to  88  yrs.)
                                  normal exposure  to  pesticides
                                  during life
                                  USA (1955)
                                      (1954-56)
                                      (1961-62)
                                      (1963)
                                      (1963)
                                  meat abstainers 1955-56
                                  Eskimos 1960
                                          1964
                                  Canada 1959-60
                                  Germany  1958-59
                                  France 1961
                                  Hungary 1960
                                  England 1961-62
                                          1964
                                  India (I) 1964
                                        (II) 1964
                                        (III) 1964

                                  USA 1964-65
                                                           kidney
                                                           liver
                                                           brain
                                                           gonad
                                                           lung
                                                           spleen
                                                   0.0827 ppm
                                                   0.0467   "
                                                   0.0105   "
                                                   0.0150   "
                                                   0.0147
                                                   0.0112
                                                           0-5 years  (white)
                                                           0.49-25.7  ppm in body fay

                                                           6+ years  (white)
                                                           1.9-21.1 ppm in body fat

                                                           0-5 years  (nonwhite)
                                                           0.81-25.4  ppm in body fat

                                                           6+ years  (nonwhite)
                                                           7.9-32.8  ppm in body fat

                                                           19.9 ppm  in body fat
                                                           11.7   "   "   "   "
12.6 "
6.7 "
11.1 "
5.9 "
3.0 "
10.3 "
4.9 "
2.3 "
5.2 "
12.4 "
2.2 "
4.0 "
26.0 "
31.0 "
12.8 "
n
n
n
n
n
n
ti
n
n
n
n
n
n
it
n
11
it
n
n
n
n
M
ti
n
it
"
ii
n
n
ii
n
n
n
ti
n
u
n
11
n
ii
n
u
it
n
n
                                                                                            3.1-8.6

-------
        TABLE IV  (COOT.) - CONCENTRATION AND EFFECTS OF ORGANIC POLLUTANTS IN HUMAN AND ANIMAL TISSUE

                   Agent	Species	Dose or  Exposure	Effect
                   DDT
                    (continued)
Human
         437
  AROMATIC DERIVATIVES

Czechoslovakia 1963-64
Israel 1963-64
      Group I (0-9 yrs.) 1965-66
      Group II (10-89yrs.)  "

normal exposure to pesticides in
Israel (range 0-89 yrs. of age)
Ln
VO
         84
                  normal exposure  to pesticides
        160
                  normal exposure through life
                                                          9.2 ppm in body fat
                                                          19.2
                                                          10.2
                                                          18.1

                                                          storage: 0-9 years (in body fat)
                                                          stillborns        1.0-49.1 ppni
                                                          neonates I (1-7 days)
                                                                            0.8-32.8  "
                                                            " II  8-30 days)l.0-14.0  "
                                                          infants (30 days to 2 years)
                                                                            1.0-60.0  "
                                                          children (3-9 yrs.)4.8-13.3 "
                                                          total             0.8-60.0  "
storage: 10-89
10-19 years
20-29 "
30-39 "
40-49 "
60-69 "
70-79 "
80-89 "
yrs. (in body f,
5.9-18.3 ppm
6.5-33.0 "
6.4-23.3 "
3.7-35.5 "
2.0-52.3 "
1.9-31.9 "
9.2-41.5 "
                                                                                            total
                                                                            1.9-82.6
                                        storage (whole tissue basis)
                                        adrenal glands    0.7 ppm
                                        storage (in extractable lipid)
                                                          3.4 ppm
                                          " periadrenal fat 7.5 ppm in
                                        extractable lipid

                                        storage found in brain, kidney,
                                        liver, gonads

                                        no correlation between conc-
                                        entration in fat and  pathological
                                        abnormalities

-------
      TABLE IV CCONT.)  - CONCENTRATION AND EFFECTS OF ORGANIC POLLUTANTS  IN HUMAN AND ANIMAL TISSUE
      R§f	Agent	Species	Dose  or Exposure	Effect
      151
DDT
(continued)
human
ON
O
      337
 AROMATIC DERIVATIVES
exposure status general population
in USA
           < 1942
             1950
             1955
             1954-56
             1961-62
meat abstainers 1955-56
Eskimos  (Alaska) 1960
residents near orchards 1954-56
agricultural applicators 1954-56
formulator 1951
formulator 1954
Canada - general population
Germany  - general population
England  - general population
France - general population
variable exposure
                                                                          0 ppm in body fat
                                                                          5.3 "
                                                                          19.9"      "     "
                                                                          11.7"
                                                                          12.9"
                                                                          5.9 '	
                                                                          3.9 "
                                                                          15.6"
                                                                          35.1"
                                                                          263 "
                                                                          1.131
                                                                          4.9 ppm
                                                                          2.3  "
                                                                          2.2  "
                                                                          5.2  "     "    "
                                                                          storage directly related to
                                                                          daily intake; correlation
                                                                          between concentration of DDT
                                                                          in blood and other tissues
                                                                          in 44 autopsies subjects with
                                                                          highest total residues in
                                                                          tissues showed emaciation,
                                                                          variety of cancers, extensive
                                                                          focal or generalized patholo-
                                                                          gical conditions of the liver

-------
       TABLE IV (CONT.) - CONCENTRATION AND EFFECTS OF ORGANIC POLLUTANTS IN HUMAN AND ANIMAL TISSUE

       Ref	Agent	Species     	Dose  or  Exposure	Effect

                                                   AROMATIC DERIVATIVES
                  DDT
                   (continued)
human
OS
       337
       405
                 normal exposure - general popula-
                 tion, male, US 1965

                 general population, female, US,
                 1965
                 general population, England, 1964    0.013 ppm in whole blood
comparison of healthy controls and
those dying of diseases of liver,
CNS, and miscellaneous pathologies
showed:

1. strong association of DDT residues
   with some CNS pathologies, carci-
   noma, portal cirrhosis and hyper-
   tension

2. equally strong association of
   these residues in sick with his-
   tories of domestic used of pesti-
   cides


0.0193 ppm in whole blood
0.0415 ppm in plasma

0.0260 ppm in serum
                 0.0021-0.0034 mg/kg/day for 12 or
                                         18 months

                 0.038-0.063 mg/kg/day
                 0.36-0.61 mg/kg/day         "
                 same as above for 21.5 months

                 lived in vicinity of aldrin and
                 dieldrin manufacturing plant
                                                                                       storage proportional to dosage
                                                                                       storage proportional to dosage
no effects
storage proportional  to dosage
white matter of brain 0.023 ppm
grey matter of brain   0.020 ppm
liver                  0.11  ppm

-------
        TABLE IV (CONT.) - CONCENTRATION AND  EFFECTS OF  ORGANIC  POLLUTANTS IN HUMAN
        Ref	Agent	Species	Dose  or Exposure	
                                                                   AND ANIMAL TISSUE
                                                                                  Effect
        72
DDT
(continued)
        83
to
o>
1-0
        189

        7L

        337

        63
        334
men and
pregnant and
lactating wo-
man (control:
nonpregnant
women)
                 fish
                 birds

                 ringneck
                 pheasants
                 penguins
                 fish
                 seals
                 snails
                 bluegill
                 sunfish
                 bald eagles
AROMATIC DERIVATIVES
normal exposure to pesticides in
metropolitan area
                                normal exposure to pesticides,
                                ordinary dietary habits
                                appreciable environmental expo-
                                sure  to pesticides from drift
                                from  fields,  orchards
                                moderate occupational  exposure
                                extensive  occupational exposure
                normal exposure

                found

                exposure  in highly treated
                areas
                exposure  in untreated  areas
                                                   20 ug/1
                normal exposure
concentration in plasma of preg-
nant and lactating women within
same range as for nonpregnant
small, significant decrease in
concentrations of all DDT derived
compounds, dieldrin, and total BHC
at or soon after delivery; returned
to levels of early pregnancy
body fat 4.9 ppm
                              ( no
body fat 6.0 ppm (difference  .; adverse
small but significant)        , effects

fat 14.0 ppm
body fat 648 ppm
range: 0.021-16.20 ppm of whole fish
average: 0.845 ppm
in all but 6 of 590 samples
(£ 45 ppm)
influences physiology of  egg; pro-
duces thinning of shell
average: 58 ppm
upper limit: 2770 ppm
<  0.18 ppm
<  0.44 ppm
<  0.12 ppm
0.16 ppm

1.0 ppm
(median values)     1965      1964
 carcass          0.20 ppm  0.42 ppm
liver          threshold    0.10

-------
     TABLE IV CCONT.) •- CONCENTRATION AND EFFECTS  OF ORGANIC POLLUTANTS IN HUMAN AND ANIMAL TISSUE
     Ref _ Agent _ Species _ Dose or Exposure _ Effect
334
DDT
(continued)
bald eagles

golden eagles
                                                   AROMATIC DERIVATIVES
normal exposure
                                                                                    (median values)   1965      1964
                                                                                    brain          threshold   threshold
                                                                                    carcass        1964-65  threshold
                                                                                    liver
                                                                                    brain
NJ

-------
TABLE V - CARCINOGENICITY IN MAMMALS OF ORGANIC POLLUTANTS FOUND IN FRESH
           WATER EXAMINED BY THE ORAL ROUTE OF ADMINISTRATION
     This table presents the available information on the carcino-
     genicity of chemicals which have been found in water and ex-
     amined by the oral route of administration.  Most of this in-
     formation was obtained from books which summarized available
     data on carcinogenicity of chemicals in general.  The majority
     of studies reported results on a few animals only and only a
     few studies attempted to show a dose response relationship.
     Dosage forms varied considerably and could not be computed to
     a common  expression.   The incidence of appearance of tumors
     were not always available and results were expressed only as
     positive.    The  results appear to be different depending
     upon the species of  animals studied with mice having the high-
     est proportion of positives.  In some instances there was a
     high tumor formation in rats used as controls.

-------
    TABLE V - CARCINOGENICITY IN  MAMMALS  OF ORGANIC  POLLUTANTS  FOUND IN FRESH WATER EXAMINED BY THE ORAL
                                         ROUTE OF ADMINISTRATION
    Ref          Agent           Species               Tumor                             Dose
ALKANES AND ALKENES
HALOGENATED
74 ALDRIN mouse 76/215
384 +
368 rat 0/120
dog 0/8
64 rat 2/61*
3/66*
2/59*
9/91*
368 BENZENE HEXACELORIDE rat 0/12
367 CHLORDANE rat ' 0/40
rabbit 0/9
74 DIELDRIN mouse 77/218
384 Positive
64 rat 8/59*
10/70*
7/62*
9/91*
368 rat Negative


10 ppm in diet for 2 yrs.
15 ppm in diet for 330 days .
25.0 ppm in diet for 2 yrs.
3 ppm in diet 6 d./wk for 15.6 mos.
2.5 ppm/ 2 yr in diet.
12.5 ppm in diet for 2 yrs.
25.0 ppm in diet for 2 yrs.
Control
100 ppm in diet up to 8 mos.
150 ppm in diet for 104 wks .
400 mg/kg daily for 31 days.
100 ppm in diet for 2 yrs .
15 ppm in diet for 375 days.
2.5 ppm in diet for 2 yrs.
12.5 ppm in diet for 2 yrs.
25.0 ppm in diet for 2 yrs.
Control
75.0 ppm in diet/6 mos.
* Considered negative because of control data.

-------
        TABLE V  (CONT.)  - CARCINOGENICITY  OF  ORGANIC POLLUTANTS FOUND IN WATER
         Ref
     Agent
Species
   Tumor
                Dose
         167
         337

         337
         367

         368
ENDOSULFAN



HEPTACHLOR

HEPTACHLOR EPOXIDE



LINDANE
                                                  ALKANES AND ALKENES
 mouse            Negative
 mouse            Postive

 mouse            Positive
 rat              0/66

 rat              0/48
                     2.15 mg/kg/d. from 7-28 days of age  (P.O.
                        stomach tube), then 6 ppm/d. in diet
                        (0.5% gelatin) for 18 mos.

                     In diet/2 yrs.

                     In diet/2 yrs.

                     30 ppm in diet/12 wks.

                     32 mg/kg in aqueous emuls.  (gastric  tube)
                        daily for 6 mos.
Isi
         368
GLUCOSE
 rat
                                                        ALCOHOLS
0/13
1 ml soln in water, 20%, in dose of 0.8 ml
   every other day/I yr.
         367
         368
                 AROMATIC
ANILINE
BENZIDINE
 rat
 rat
                                       dog
                                                         AMINES
4/12


2/10

2/10

3/10
0/2
1.10% in synthetic basic diet, 10-65 mg/d./
   body weight.
0.1% in diet/312 days.

0.017% in diet for 224 days.
0.017% in diet for 424 days.
0.50-0.1 g once a wk for 20-128 days.

-------
        TABLE V  (CONT.)  - CARCINOGENICITY OF ORGANIC POLLUTANTS FOUND IN WATER
        Ref
Agent
Species
Timor
                                                                                            Dose
BENZIDINE
(continued)
Jo/
148 a-NAPHTHYLAMINE
368 B-NAPHTHYLAMINE
rabbit
dog
rat
dog
AMINES
0/9
1/7
1/10
9/9
10/10
0.50-0.1 g once a wk for 20-128 days.
200 rag in capsule daily (6/wk) for 15 mos.
followed by 300 mg in capsule daily
(6/wk) for 45 mos (total 325 gm) .
0.06% in food for 288 days.
300 mg capsule in diet daily for 24-35 mos
600 mg capsule daily. Dose varied up to
N>
ON
                                  2/4

                                  1/3
                                  2/7
                                  3/3
                                  3/5
                                  1/6
                                  3/3
                                  1/3
                                  2/2
                                  1/2
                                  2/2
                                  2/3
                                  3/3
                                  5/5
                                          17 mos.
                                        200 mg  in gelatin  capsule 6 d./wk  (increased
                                          after  6 mos  to  600 mg:  max cumulative
                                          dose 310  gm/animals)  for 3 yrs.
                                        500 mg  daily/18 mos.
                                        500 mg  daily/26 mos.
                                        500 mg  daily/35 mos.
                                        500 mg  daily/34 mos.
                                        500 mg  daily/34 mos.
                                        500 mg  daily/31 mos.
                                        30 mg daily/ 24 mos.
                                        90 mg daily/29  mos.
                                        60 mg daily/ 29 mos.
                                        120 mg  daily/  22 mos.
                                        500 mg  daily/29 mos.
                                        500 mg  daily/30 mos.
                                        300 mg  daily in food for 372  days.

-------
      TABLE V (CONT.)  - CARCINOGENICITY OF ORGANIC POLLUTANTS FOUND IN WATER
      Ref
Agent
Species
                                                        Tumor
                                                                                           Dose
to
368 e-NAPHTHYLAMINE
(continued)
68
HETEROCYLIC
367 PYRIDINE
CARBOXYLIC
367 ACETIC ACID
367 n-BUTYRIC ACID
368 2,4-D
367
167
367 2,4,5-T
167
rat
rabbit
dog
rhesus monkey
mouse
rat
rabbit
rat
rat
dog
mouse
dog
mouse
AMINES
6/11
2/29
I/
9/24
Negative
0/8
ORGANIC ACIDS
0/5
+/4
0/5
0/11
Negative
0/11
Negative
0.067% in diet/925 days.
0.1% so In. for 2 yrs. Avg. intake 350 mg/day.
25-50 mg/kg/d./24 mos.
50-100 mg/kg/d./24 mos.
200 mg/kg/d./24 mos.
10% in diet/35 days.
0.1-0.7 gm/kg weight, dissolved in 50-100 ml
drinking water, twice daily for 13 mos.
25% in synthetic diet for 3-35 wks.
1 ml of 2% soln in water in diet/daily/6 mos.
2, 5, 10 or 20 mg/kg in capsules, 5 d./wk/
13 wks.
100 mg/kg/d. from 7-28 days of age (P.O.
stomach tube) , then 323 ppm/d. in diet
(0.5% gelatin) for 18 mos.
20 mg/kg in capsules, 5 d./wk/113 wks.
21.5 mg/kg/d. from 7-28 days of age (P.O.
                                                                              stomach tube), then 60 ppm/d. in diet
                                                                              (0.5% gelatin) for 18 mos.

-------
    TABLE V (CONT.) - CARCIHOGENICITY OF ORGANIC POLLUTANTS FOUND IN WATER
    Ref
     Agent
Species
Tumor
                                                                                        Dose
    188
     368
             SULFONICS
ABS
                      mouse
                      rabbit
1,2-BENZANTHRACENE    mouse
     368
1,12-BENZOPERYLENE    mouse
3,4-BENZPYRENE       mouse
00
     368
               ORGANIC ACIDS

                  Negative
                  Negative
                  Positive

                  Positive

                  Negative
                  +/55

                  +/30

                  +/20
                  +/24

                   17/20
                   10/30

                   +/20
                   +/20
                   +/20
                   +/20
                  0.5 mg in 0.1 ml heavy mineral oil 8 times at
                     3-7 d. intervals.
                  0.5 mg in 0.1 ml heavy mineral oil 16 times
                     at 3-7 d. intervals.
                  0.3 ml of 0.5% PB in PEG*solvent, once (30
                     weekly doses  .3 ml of 3% croton oil in
                     PEG after  treatment).
                  30 wkly adm.  of  0.3 ml  of 0.5% carcinogen in
                     polyethylene  glycol-400.
                  1 dose of 0.3 ml of 0.5% carcinogen in PEG-400.
                  0.3 ml of 0.5% in PEG solvent once (30 wkly
                     doses  .3 ml of PEG after treatment).
                  0.3 ml of 0.5% in PEG solvent.
                  0.3 ml of 0.5% in PEG/3 times at  24 hr
                     interval/30 wks.
                  12.5  ygm  in 0.25 ml PEG once.
                  50 ygm in 0.25 ml PEG once.
                  200 ygm in 0.25  ml PEG  once.
                  12.5  ygm  in 0.25 ml PEG once.
       PEG - polyethylene glycol

-------
   TABLE V  (CQNT.)  - CARCINOGENICITY  OF  ORGANIC  POLLUTANTS FOUND  IN  WATER
   Ref
Agent
Species
                                                     Tumor
                                                                                      Dose
ORGANIC ACIDS
148 CHRYSENE rat Negative
148 1,2,5,6- mouse 3/10
DIBENZANTHRACENE 2,10
148 PENTACHLOROPHENOL rat 0/20
cat 0/4
148 PENTACHLOROPHENATE, rabbit 0/5
Na
AROMATIC DERIVATIVES
fT HALOGENATED
CT»
VO
368 ODD mouse Negative
167 ^Potential
402 DDT mouse 196/683
167 Positive
100 rat Positive
fish, trout Positive
107 rat 15/75
0.3% in diet/ 30 days.
10 mg (total dose) in diet/7 mos.
19 mg (total dose) in diet/5 mos.
3.9 or 5 mg in food daily/26-28 wks.
1.25 or 2.8 mg/kg in diet/10 wks.
35-600 mg/kg in water for 34 days.
0.1% in diet up to 6 wks.
100 mg/kg/d. from 7-28 days of age (P.O.
stomach tube), then 300 ppm/d. in diet
(0.5% gelatin) for 18 mos.
Five generations of mice fed DDT at 2.8-3.0
ppm of the diet for 6 mos.
46.4 mg/kg/d. from 7-28 days of age (P.O.
stomach tube) , then 140 ppm/d. in diet
(0.5% gelatin) for 18 mos.
200-800 ppm in diet for near-life span.
75 ppm.
100, 200, 400 and 800 ppm in diet for 18 mos.
* Requires additional  evaluation.

-------
        TABLE V CCONT.) - CARCINOGENICITY OF ORGANIC  POLLUTANTS  FOUND  IN WATER


        Ref    	Agent	Species	Tumor  	Dose   	


                                          MERCAPTANS AND OTHER SULFUR ORGANICS

        167     TED ION                mouse            Negative             100 mg/kg/d. from 7-28 days of age (P.O.
                 (TETRAFIDON)                                                    stomach tube), then 260 ppm/d. in diet
                                                                                (0.5% gelatin) for 18 mos.
to
^J
O

-------
TABLE Va - CARCINOGENICITY IN MAMMALS OF POTENTIAL ORGANIC POLLUTANTS
           FOUND IN FRESH WATER IN HUMANS,  ANIMALS, AND PLANTS
     This table presents available information on the carcinogen-
     icity of chemicals found in water which were not examined by
     the oral  route of administration.

-------
  TABLE Va - CARCINOGENICITY IN MAMMALS OF ORGANIC  POLLUTANTS FOUND  IN  FRESH WATER EXAMINED BY ROUTES OF
                                        ADMINISTRATION OTHER THAN ORAL
   Ref
     Agent
Species
  Tumor
                Dose
   367
           ALIPHATIC
ETHYLAMINE
 rabbit
                                                   AMINES
0/6
50 and 100 ppm 7 hrs./day, 5 day/week, for 6
 weeks.  (Inhalation)
  148      FLUORANTHENE

  368      PYRENE
                      mouse

                      mouse
               ORGANIC ACIDS

                   0/10

                   +/150


                   6/20
to
•vj
                    0.3% in benzene twice weekly.  (Skin)

                    3 drops 3% in acetone once weekly (followed by
                     1 drop 5% croton oil in mineral oil once weekly)

                    10 thrice weekly applications of 8.3% solution
                     in acetone (total dose - 0.25 g).  (Skin)
  148
p-CRESOL
            PHENOLS and QUINONES

 mouse             Negative

 rat               Negative
                    3% in alcohol 3 times weekly.  (Skin)

                    3% in alcohol 3 times weekly.  (Skin)

-------
TABLE VI - CARCINOGENICITY IN MAMMALS OF POTENTIAL ORGANIC POLLUTANTS OF
       FRESH  WATER EXAMINED BY THE ORAL ROUTE OF ADMINISTRATION
     This table presents available information on carcinogenicity
     of chemicals  which are considered to be potential pollutants
     of fresh water and any statements that could be made about
     this table are the same as those presented for Table V.

-------
     TABLE VI - CARCINOGEN 1CITY  IN MAMMALS OF POTENTIAL ORGANIC POLLUTANTS OF  FRESH WATER EXAMINED  BY  THE ORAL
                                           ROUTE OF ADMINISTRATION

     Ref          Agent           Species              Tumor                             Dose
              HALOGENATED

     368*     CARBON TETRA-
                CHLORIDE
to
148     CHLOROFORM

165

167     MIREX



167     STROBANE
      367     TETRACHLORO-
              ETHYLENE

      148     TETRACHLORO-
                ETHANE
         ALKANES AND ALKENES



dog              0/8

mouse            +/37

                 Positive


mouse            7/20

                 0/40

mouse            Positive



mouse            Positive



rat              0/18


dog              0/1
0.125-0.5 ml/kg 3 x wk in a 1:1 soln  and
   corn oil.
0.2 ml of 2% olive oil soln. 2 x wk interval,
   3% soln. given wkly for 17 wks.
0.1 ml of 40% soln. in olive oil, 3 x wk for
   45-66 doses/13 1/2 wks.

8 x 10-lf and 4 x lO"1* ml dose in olive oil
   every 4 days, 30 times.
2% in diet/13 mos.

10 mg/kg/d. for 7-28 days of age (P.O. stomach
   tube), then 26 ppm/d. (0.5% gelatin) in
   diet for 18 mos.

4.64 mg/kg/d. for 7-28 days of age (P.O.
   stomach tube), then 11 ppm/d. for 18 mos
   (in diet 0,5% gelatin).

0.33 mg/kg, 8 doses at 4 d. interval.
                                                                     1 ml  150 times.
  * Additional data in 148 and 367.

-------
TABLE VI (CONT.) - CARCINOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
Ref
    Agent
Species
  Tumor
                                                                                     Dose
148 AMYL ALCOHOL rat
368 t-BUTYL ALCOHOL rat
368 DIETHYLENE GLYCOL rat
368 ETHYL ALCOHOL rat
rat
148 ETHYLENE GLYCOL rat
148 ETHYLENE GLYCOL rat
MONO-n-BUTYL ETHER
148 ETHYLENE GLYCOL rat
MONOETHYL ETHER
368 PROPYL ALCOHOL rat
367 HEXAMETHYLENE- guinea pig
ALCOHOLS
Negative
0/4
0/24
0/10
0/60
0/30
0/40
0/20

0/4
AMINES
0/6
In food.
10% in basal diet for 30 d., 20% for 30
more days.
1% and 2% in drinking water/ 13 1/2 wks.
40 ml at 40° added to 100 gm of diet at
15° as drinking water/152 days.
15% in drinking water/226 days.
50% in water, 2 ml/kg body wt. every other
day for 8-79 days .
0.03%, 0.125%, 0.5% or 2.0% incorporated in
diet (total of 0.018 g/kg/d.) for 90 days
1.45% in food/2 yrs.

10% in diet for 30 d.; 20% in diet for 30
more days.
0.02 g daily/98 days.
 367
DIAMINE

QUATERNARY

ALKYL DIMETHYL BENZYL
AMMONIUM CHLORIDE
    rat
0/168
                                                                     0.015-0.5% in diet/2 yrs.

-------
TABLE VI (CONT.) - CARCINOGENICITY OF  POTENTIAL ORGANIC POLLUTANTS
Ref
    Agent
Species
  Tumor
                                                                                     Dose
367     CETYL DIMETHYL
        ETHYL AMMONIUM
        BROMIDE

        HETEROCYCLICS

167     AMITROLE
 167      ATRAZ1NE
 167      SIMAZINE
                     mouse
                               mouse
                      mouse
                      mouse
                                        AMINES

                                       0/10
                                       Positive
                  Negative
                  Negative
                                       0.060 gm/kg daily, 6 d./wk/30 days,
                     1000 mg/kg/d.  for  28  d.  (P.O.  stomach  tube)
                        then  2192 ppm (0.5%  gelatin)  in  diet  for
                        18 mos.

                     21.5 mg/kg/d.  for  7-28  days  of age  (P.O.
                        stomach  tube) then 82 ppm/d.  in  diet
                        (0.5% gelatin)  for 18 mos.

                     215 mg/kg/d.  for 7-28 days of  age (P.O.
                        stomach  tube),  then  603 ppm/d. in diet
                        (0.5% gelatin)  for 18 mos total.
                                             ORGANIC ACIDS
         CARBOXYLIC

 148      CAPROIC ACID

 367     LACTIC ACID
                      rat

                      rabbit
                   0/2

                   0/5
                     10% in food/110 days.

                     0.1-0.7 gm/kg dissolved in 50-100 ml water,
                        twice daily for 16 mos (13 mos actual
                        treatment).
 368
TANNIC ACID
  rabbit
0/4
1 g/kg body weight daily/40 days.

-------
TABLE VI (CONT.) - CARCINOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
Ref
Agent
Species
Tumor
                                                                                    Dose
367
368
367
167
to
Ul
100

390
301


318
367
148
SULFONICS
DECYLBENZENE mouse
SULFONATE, Na
DODECYLBENZENE rat
SULFONATE. Na
ISOPROPYLNAPHTHA- mouse
LENE SULFONATE, Na
ARAMITE mouse
rat
dog
dog
rat
mouse
dog
rat
DIBUTYLPHTHALATE rat
ETHYL ACETATE rat
ORGANIC ACIDS
0/10
0/20
0/10
ESTERS
Positive
Positive
Positive
Positive
+/1500
4-/1000
+/36
+/300
0/40
Negative
0-210 gin/kg daily, 6d./wk/30 days.
2000 ppm in diet/104 wks.
0.19 gin/kg daily, 6 d./wk/30 days.
464 mg/kg/d. for 7-28 d. of age (P.O. stomach
tube), then 1112 ppm/d. (0.5% gelatin)
in diet for 18 mos .
200-400 ppm.
500-1400 ppm.
500-1429 ppm/d. /3 1/2 yrs in diet.
200-400 ppm in diet for 2 yrs.
200-400 ppm in diet for 2 yrs.
500-1400 ppm in diet for 3.5 yrs.
200-400 ppm in diet for 2 yrs.
0.01-1.25% in diet/1 yr.
In diet/^300 days.

-------
    TABLE VI (CONT.) - CARCINOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
    Ref
             Agent
                     Species
                    Tumor
                                          Dose
    167     OVEX
    167     n-PROPYL  ISOME
    337     PYRETHRINS
                                  mouse
                              mouse
                                   rat
                                                    ESTERS
                                               Negative
                                       Negative
                                               *Potential
                                      464 mg/kg/d. for 7-28 days of age (P.O.
                                         stomach tube), then 1019 ppm/d. in diet
                                         (0.5% gelatin) for 18 mos.

                                      2000 yg/kg/d. from 7-28 days of age (P.O.
                                         stomach tube), then 6000 ppm/d. in diet
                                         (0.5% gelatin) for 18 mos.
to
148

167



367

368
     167
      49
AMIDES

CAPROLACTAM

CAPTAN



SULFAGUANIDINE

SULFANILAMIDE


CARBAMATES

CARBARYL
rat

mouse



rat

rat
                              mouse
                              rat
AMINE DERIVATIVES



     0/6

     Negative



     0/24

     0/12
                 Negative
                                       Negative
Avg. of 0.667 g/kg/d. in drinking water/70 days,

215 mg/kg/d. for 7-28 days of age (P.O.
   stomach tube), then 560 ppm/d. in diet
   (0.5% gelatin) for 18 mos.

1% in diet/70 d., 12 with Vitamin E rich diet.

Rat cube diet containing sulphanilamide at
   levels of 0.04%/450 days.
                          4.64 mg/kg/d. for 7-28 days of age  (P.O.
                             stomach tube), then 14 ppm/d. in diet
                             (0.5% gelatin) for 18 mos.

                          0.04,  .02, .01,  and  .005% in diet for 2 yrs.
 *  Requires additional  evaluation

-------
         TABLE  VI (CONT.)  -  CARCINOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
          Ref
     Agent
Species
Tumor
Dose
Ni
           49     CARBARYL
                  (continued)

          222     CHLOROPROPHAM
          167      IPC
          164
          167      ISOLAN
          167      ZECTRAN
          167


          159

          167
                  THIOCARBAMATES
FERBAM
NABAM
                       dog


                       rat

                       dog

                       mouse



                       rat

                       mouse

                       mouse
                                        mouse
                      mouse
                      rat
                                       mouse
             AMINE DERIVATIVES

                  Negative


                  Negative

                  Negative

                  Negative



                  Negative

                  Negative

                  Negative
                                       *Potential
                  Negative


                  Negative

                  Negative
                  414, 95, and 24 ppm in diet for 1 yr.


                  2.0% in diet for 2 yrs.

                  2.0% in diet for 1 yr.

                  215 mg/kg/d. for 7-28 days of age (P.O.
                     stomach tube), then 560 ppm in diet
                     (0.5% gelatin) for 18 mos.

                  2% in diet for 18 mos.

                  2% in diet for 18 mos.

                  0.0215 mg/kg/d. from 7-28 days of age (P.O.
                     stomach tube), then 0.0603 ppm/d. in
                     distilled water for 18 mos.

                  4.64 mg/kg/d. from 7-28 days of age (P.O.
                     stomach tube), then 11 ppm/d.  in diet
                     (0.5% gelatin) for 18 mos.
                  10 mg/kg/d. from 7-28 days of age (P.O.
                     stomach tube), then 32 ppm/d.  in diet
                     (0.5% gelatin) for 18 mos.
                  .0025, .025, and .25% in diet/2 yrs.

                  21.5 mg/kg/d. from 7-28 days of age (P.O.
                     stomach tube), then 73 ppm in  distilled
                     water for 18 mos.
     * Require additional evaluation.

-------
         TABLE VI (.COOT.) - CARCINOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
         Ref
     Agent
Species
   Tumor
                                                                                              Dose
S3
^j
oo
         167


         100

         167


         159

         167
         167
          167
THIRAM
ZIRAM
ZINEB



UREAS

DIURON



MONURON
                      mouse
  mouse
  mouse
                                                   AMINE  DERIVATIVES
                  Negative
rat
mouse
rat
mouse
Positive
Negative
Negative
*Potential
Negative
                                                         *Potential
                     10 mg/kg/d. from 7-28 days of age (P.O.
                        stomach tube), then 26 ppm/d. in diet
                        (0.5% gelatin) for 18 mos.
                                       4.6 mg/kg/d.  from 7-28  days  of  age  (P.O.
                                          stomach  tube),  then  15  ppm/d.  in diet
                                          (0.5%  gelatin)  for 18 mos.
                                       0.0025,  .025,  and .25%  in  diet/2  yrs.

                                       464 mg/kg/d.  from 7-28  days  of  age  (P.O.
                                          stomach  tube),  then  1298  ppm/d.  in  diet
                                          (0.5%  gelatin)  for 18 mos.
464 mg/kg/d. from 7-28 days of age (P.O.
   stomach tube), then 1000 ppm/d. in diet
   (0.5% gelatin) for 18 mos.

215 mg/kg/d. from 7-28 days of age (P.O.
   stomach tube), then 517 ppm/d. in diet
   (0.5% gelatin) for 18 mos.
          367
                  MALATHION
                       rat
                                                     PHOSPHATE ESTERS
                   Negative
                     5000 ppm in diet as 65, 90, or 99%
                        technical product for 2 yrs.
      *Requires additional evaluation.

-------
       TABLE VI (CQNT.)  - CARCINOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
       Ref
             Agent
Species
   Tumor
                                                                                           Dose
       148     ACETALDEHYDE          rat

       148     METHYL ETHYL KETONE   rat
                                        ALDEHYDES AND KETONES

                                               Negative

                                               Negative
                                       In diet/300 days.

                                       In food/300 days.
                                                        ETHERS
to
V4
VO
       148

       167
147
167
        DIOXANE               rat

        PIPERONYL BUTOXIDE    mouse
               ROTENONE
 rat
 mouse
                  0/2

                  *0
Negative
Negative
1% in water/110 days; 3% in water/48 days.

100 mg/kg/d. from 7-28 days of age (P.O.
   stomach tube), then 300 ppm/d. in diet
   (0.5% gelatin) for 18 mos.

5-15 mg/kg body weight daily/37 days.
1 mg/kg/d. from 7-28 days of age (P.O.
   stomach tube), then 3 ppm/d. in diet (0.5%
   gelatin) for 18 mos.
       368
        NAPHTHALENE
 rat
                                              UNSUBSTITUTED AROMATICS
Negative
In oil (in synthetic diet) 6 times a week,
   10-20 mg until dose of 10 g/rat in food.
       367     2,4-DINOTROPHENOL     rat

       367     6-NAPHTHOL            rat
                                         PHENOLS AND QUINONES

                                               Negative

                                               0/5
   * Requires additional evaluation.
                                       0.01-0.10 in diet/179 days.

                                       2% in diet/2 mos.

-------
    TABLE  VI CCONT.)  - CARCINOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
     Ref
10
oo
o
    Agent
Species
                                                       Tumor
                                                                                         Dose
AROMATIC DERIVATIVES
HALOGENATED
368 p-DICHLOROBENZENE rabbit
100 METHOXYCHLOR rat
158 rat


167 PERTHANE mouse

0/7
Positive
+/13
+/10
+/16
*Potential

500 rag/kg fed 5 d./wk for a total of 263 doses
2000 ppm for 18 mos.
0.0025% in diet/18 mos.
.02% in diet/ 18 mos.
.16% in diet/ 18 mos.
215 mg/kg/d. from 7-28 days of age (P.O.
     368
              ARYLALKANES
TOLUENE
  rat
Negative
                                                                             stomach  tube),  then  815  ppm/d.  in diet
                                                                             (0.5%  gelatin)  for 18 mos.
118, 354, or 590 mg/kg/d. in 2-3 ml olive oil
   soln. emulsified and 5-10% aqueous soln.
   of acacia for 138 feedings.
  *  Requires additional evaluation.

-------
TABLE Via - CARCINOGEN1CITY IN MAMMALS OF POTENTIAL ORGANIC POLLUTANTS
     OF FRESH WATER EXAMINED ONLY BY ROUTES OF ADMINISTRATION
                           OTHER THAN ORAL
     This table  presents available information on carcinogenicity
     of chemicals which  are potential pollutants of fresh water
     and which  were not examined by the oral route of administra-
     tion.

-------
OO
       TABLE Via - CARCINOGENICITY IN MAMMALS OF POTENTIAL ORGANIC POLLUTANTS  OF  FRESH WATER EXAMINED ONLY  BY ROUTES
                                              OF ADMINISTRATION OTHER THAN ORAL
        Ref
Agent
Species
                                                         Tumor
                                                                                           Dose
148
148
368
367
367

367
367
148
368
HALOGENATED
DICHLOROMETHANE
ETHYLENE DIBROMIDE
TRICHLORETHYLENE
2-ETHYL HEXANEDIOL-
1,3
STREPTOMYCIN

ALIPHATIC
DIETHYLAMINE
PHENYLHYDRAZINE
HETEROCYCLICS
ACRIDINE
NICOTINE
ALKANES AND ALKENES
animal 1 Negative
rat Negative
cat Negative
ALCOHOLS
animal1 Negative
guinea pig Negative
AMINES
rabbit Negative
rabbit 0/2
mouse 0/100
rat 0/16
34 mg (10,000 ppm) 5 x wk. , 4 hr. exposure.
(Inhalation)
50 ppm air, up to 63 seven hr. exposures daily.
(Inhalation)
20 ppm, 75 min. daily. (Inhalation)
Undiluted daily/90 d. (Skin)
13.7-55.8 gm/kg body weight (total dose). (I.M.)*

50 and 100 ppm 7 hrs/d./wk./16 weeks. (Inhalation)
40 mg (S.C.).*
1% in "90% benzol"/9 mos. (Skin)
2.5 mg (as the bitartrate) for 10 doses, 4 mg
every work day for 4 mos., then 2 mg every
work day until 6-1/2 mos. (S.C.)
         I.M.  - intramuscular
         S.C.  - subcutaneous

-------
       TABLE Via .(CONT.) - CARCINOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
       Ref
             Agent
Species
Tumor
Dose
ORGANIC ACIDS
CARBOXYLIC
148 BENZOIC ACID rabbit Negative
148 PHTHALIC ACID rabbit Negative
148 TRICHLOROACETIC mouse Negative


Daily/40 days. (S.C.
Daily/40 days. (S.C.
In acetone, weekly, 3


or I.V.)*
or I.V.)
applications.




(Skin)
                ACID
10
00
368     ACETONE

148     ACETOPHENONE

368     ACROLEIN
        367      CYCLOHEXANONE


        368      FORMALDEHYDE
        368      BENZENE
           ALKEHYDES AND KETONES

 mouse             Negative

 rabbit            Negative

 mouse             2/15
                              guinea pig        Negative


                              rat               4/10


                                    UNSUBSTITUTED AROMATICS

                              mouse             +/21

                                                +/36

                                                +/40

                                                Negative
                  0.2 ml of 100% 3 x week/1 year.   (skin)

                  Daily/40 days.  (S.C. or I.V.)

                  10 weekly applications of 0.5% solution in
                   acetone (total dose - 12.6 rag)  (weekly
                   application of croton oil in acetone begun  25
                   day post-treatment 2 of 0.08% solution and
                   16 of 0.17% solution, alternating with test
                   substance at 3-4 day intervals).  (Skin)
                  10 mg/20 days, 50 mg/40 days, and 100 mg/20-
                   40 days.  (S.C.)
                                       1 cc of a 0.4% aqueous solution, weekly/15
                                        (S.C.)
                                                             mos,
                                       Twice weekly.   (Skin)
                                       25 yl 2 x wk/24 weeks.   (Skin)
                                       Painted 2 x week/40 weeks.   (Skin)
                                       Once a week/4 mos., thrice weekly thereafter for
                                        108 applications in 12 mos.  (total dose -
                                        8.9 gin).  (Skin)
        *  I.V.  intravenous

-------
TABLE Via (CONT.) - CARCINOGENIGITY OF POTENTIAL ORGANIC POLLUTANTS
Ref
Agent
Species
Tumor
Dose
UNSUBSTITUTED AROMATICS
368 PHENANTHRENE mouse +/100
5/20
PHENOLS AND QUINONES
148 CATECHOL rabbit Negative
367 GUAIACOL rat Negative
148 a-NAPHTHOL mouse Negative
148 PYROGALLOL mouse, Negative
g rabbit
u>
AROMATIC DERIVATIVES
NITRO COMPOUNDS
148 XYLENE mouse Negative
SULFUR ORGANICS
3 drops 3% in acetone once weekly followed by
1 drop 5% croton oil in. mineral oil once wkl;
10 thrice weekly applications of 18.0% solutii
in acetone (total dose - 0.54 g) . (Skin)
Daily for 40 days. (S.C. or I.V.)
1-4% in olive oil, 26 inj . (S.C.)
5% in lard (0.25 ml, repeated inj.). (S.C.)
5-20% in acetone weekly. (Skin)
Weekly application. (Skin)
367     MUSTARD GAS
                              mouse
                                   Negative
                                       250 pg/ml in acetone, 0.05 ml, 5 times weekly.
                                        (Skin)

-------
TABLE VII - MUTAGENICITY AND TERATOGENICITY OF ORGANIC POLLUTANTS FOUND
              IN FRESH WATER IN HUMANS, ANIMALS, AND PLANTS

                                  AND

TABLE VIII - MUTAGENICITY AND TERATOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
               OF FRESH WATER IN HUMANS, ANIMALS, AND PLANTS
     These tables contain available information with more or less

     pertinence to mutagenicity and teratogenicity on chemicals

     found in water.   In considering presumptive tests for muta-

     genicity, caution is necessary for interpreting the results.

     It can be  seen from the tables that a variety of test systems

     have been employed  and it should be remembered that most are

     of little  reliability in terms of extrapolating to man.

     Further reservations with respect to pesticides are needed

     because no pesticides now in wide use have been demonstrated

     to be mutagenic and the overwhelming majority has not been

     adequately tested.  The majority of data in this table relates

     to mutagenicity or chromosomal effects obtained on plants or

     fungi.  The teratogenicity information showed positive results

     on 29 of 32 chemicals and one of these was obtained on humans

     (methyl mercuric chloride).  The data on the chick needs to be

     qualified since it is considered by some to be an overly sensi-

     tive system.

-------
         TABLE VII - MUTAGENICITY AND TERATOGENICITY OF ORGANIC POLLUTANTS FOUND IN FRESH WATER IN HUMANS,
                                         ANIMALS AND PLANTS
                         MUTAGENICITY
                                                                                        TERATOGENICITY
OO
Agent
HALOGENATED
DIELDRIN

ENDRIN
LINDANE



Species
Plant
sprout
Barley
Onion
root tip

1!
Other
plant
root tip
Dose
10% soln.

1000 ppm
for 12 hrs.

0.00125%
0.0006-
2.0%
solid
particles
Effect Ref Species Dose Effect Ref
ALKANES AND ALKENES
C-mitosis 337

Point 453
mutations
Chromosome 337 Chick 5 mg/egg Negative 244
breaks
Aneuploidy 337
and chromo-
some frag-
mentation
C-mitosis 337
Chromosome 337
aberrations

-------
TABLE VUL (CONT.) - MUTAGENICITY AND TERATOGENICITY OF ORGANIC POLLUTANTS
               MUTAGENICITY
TERATOGENICITY
Agent Species
CARBOmiC
2,4-D Narcissus
root tip
Cotton
NO
oo
l/l
Onion root
tip
Vicia faba
root tip
Onion root
tip
Trades cantia
2,4,5-T Apricot
Onion root
tip
Dose
0.01-
0.1%
0.01-
0.1%
0.001-
0.1%
25-500
ppm
0.001-
0.1%
100 mg/1
sprayed
25-500
ppm
Effect Ref
ORGANIC ACIDS
C-mitosis 337
Effect on 25
nucleic acid
synthesis
C-mitosis 337
chromosome
aberrations
Abnormal 337
mitosis
Chromosome 337
aberrations
Abnormal 356
mitosis
Slight anti- 36
mitotic effect
Chromosome 337
aberrations
Species Dose Effect Ref
Mouse 98 mg/kg Eye anomalies 337
Mouse 98-100 Negative 337
mg/kg
Mouse 46-150 Eye anomalies, 95
mg/kg S.C. agnathia
day 6-14



Mouse 113 mg/kg Cleft palate 337
Cystic kidney
Mouse 150 mg/kg Cleft palate 95
Chick Cleft plate 76
                                                                                          Beak deformities

-------
         TABLE VII (COOT.) - MUTAGENICITY AND TERATOGENICITY  OF  ORGANIC POLLUTANTS
                          MUTAGENICITY
                                                                                         TERATOGENICITY
N3
00
Agent 	
BENZOPYRENE
1,2,5,6-
DIBENZ-
ANTHRACENE
Soecies Dose Effect
Ref Species Dose Effect Ref
UNSUBSTITUTED AROMATICS
Mouse 750 mg/kg Induction of
I. P. single dominant
dose lethals
Fungus Positive
96
21
PHENOLS AND QUINONES
PENTACHLORO-
PHENOL
Plant cells Positive
11
AROMATIC DERIVATIVES
HALOGENATED
DDD
DDT


Mouse 105 mg/kg Negative
Plant saturated C- Mitosis
solution Chromosome
breaks
Mouse 46.4 mg/kg Negative 33
96 Chick Negative 24
337
          TEDION
                                        MERCAPTANS AND OTHER SULFUR ORGANICS
                                                                             Mouse
217 mg/kg  Negative
                                                                                                                 337

-------
           TABLE VII (CONT.) - MUTAGENICITY AND TERATOGENICITY OF ORGANIC POLLUTANTS
                            MUTAGENICITY
                                                                                          TERATOGENICITY
           Agent
Species
Dose
Effect
Ref
Species	Dose
                                                                                                     Effect
                                                                                      Ref
           METHYL MERCURY  Fruit fly    0.25 ppm
                                        in food
                                                          ORGANOMETALICS
                          Offspring
                          with extra
                          chromosome
                                      Human     From fish    Congenital  169
                                                             cases born
ro
00

-------
TABLE VIII - MUTAGENICITY AND TERATOGENICITY OF POTENTIAL ORGANIC POLLUTANTS OF FRESH WATER IN HUMANS,

                                 ANIMALS AND PLANTS
  Agent
MUTAGENICITY

Species	Dose
                                                                                 TERATOGENICITY
Effect
Ref
Species	Dose
Effect
Ref
  HALOGENATED

  CHLOROFORM

  ETHYLENE
  DIBROMIDE
 Onion

 Bull  testis
ALKANES AND'ALKENES



Positive      389

Positive       12


     AMINES
£ HETEROCYCLIC
oo — - - .
ATRAZINE
SIMAZINE

Barley
anther
Barley
anther

1000 ppm
for 12 hrs
1000 ppm
for 12 hrs

On meiosis 453
On meiosis 453
ORGANIC ACIDS
  CARBOXYLIC
  ENDOTHALL
Plant cell
Chromosome
aberrations
                                                ESTERS
                                                          337
                                                                    Mouse
                                                                          Negative    337
  OVEX
                                                   Mouse
                                                Negative    337

-------
                           MUTAGENICITY
                                                  TERATOGENICITY
Agent
Species Dose
Effect
Ref
Species Dose Effect
Ref
AMINE DERIVATIVES
AMIDES
CAFTAN

Human 0

.010 mg/1
in culture





Mouse 9

Kangaroo rat 1

& 500 mg/kg

.25 & 5.0

Inhibition of
DNA synthesis

Negative

Chromosome

225


96

225

Mouse Negative

Chick 18-20 ppm Cleft palate
Eye anomalies
Bone anomalies
(~* *-\T^ rr r\ m -I <- i 1

337

421


o/. /.
to
oo
vo
mg/1 in      aberrations
culture
          METEPA
                          Mouse
          TEPA
             Point mutations 337
             Chromosome
             alterations

40 mg/kg     Induction of     96
             dominant
             lethals

             Point Mutations  337
             Chromosome
             alterations
Rabbit

Rat

Hamster


Rat
           malformations

           Negative    183, 187

50-2000 mg/kg Negative    183
P.O.
125-1000   Negative       183
mg/kg P.O.
           Ectrodactyly
           Multiple mal-
           formations
187
                                                    Positive
                              51

-------
          TABLE VIII (CONT.) - MUTAGENICITY AND TERATOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
                           MUTAGENICITY
                                                                               TERATOGENICITY
          Agent
                Species
             Dose
             Effect
              Ref
 Species	Dose
           Effect
               Ref
                                                     AMINE DERIVATIVES
          TEPA  (cont.)
                          Mouse
                                          Positive
                                                         52
                             7 mg/kg I.P. Induction of   95
                                          dominant
                                          lethals
10
vo
o
          CARBAMATES
CARBARYL
Barley
anther
Plant
root tip
500 & 1000
ppm 12 hrs
0.5 & 0.25
saturated
Abnormal meiosis 453
                                                    Chromosome
                                                    aberrations
                                                         10
Mouse
                                                                   Guinea pig
                                                                             Hamster
                                                                             Chick
                                                                             Dog
100 mg/kg
Hydrocephaly,
skeletal
337
                                     300 mg/ kg Bone defects    339
                                     P.O. dur-  Lack of kidneys
                                     ing organ- and genital
                                     ogenesis   organs
                                                                                         350 mg/kg
                                                                                          Congenital mal- 187
                                                                                          formations
                                                                               125 & 150  Negative
                                                                               mg/kg P.O.
                                                                               1 mg/egg
                                                                          Congenital
                                                                          ma 1fo rmat ions
                                                                               75 ppm/day Congenital
                                                                                          malformations

                                                                               6.25-50    Skeletal
                                                                               mg/kg/day  anomalies
                                                                                          Failure in
                                                                                          organ devel-
                                                                                          opment
                                                                                          339
                                                                             244
                                                                                                                    187
                                                                                          374

-------
          TABLE VILI (CONT.) - MUTAGENICITY AND TERATOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
                          MUTAGENICITY
                                                               TERATOGENICITY
                          Species
             Dose
Effect
Ref
Species	Dose
Effect
Ref
                                                    AMINE DERIVATIVES
VO
          CIPC
          IPC
          ZECTRAN
Plant cell   2.5,5,10,20, C-Mitotic     242
             40,80 ppm    effect
             up  to 8 hrs  Nuclear dis-
                          integration

Avena root   0.1-0.5 ppm  Mitotic       337
and stem tip              aberrations
Plant cells  2.5,5,10,20, C-Mitotic     242
             40,80 ppm    effect
             up  to 8 hrs  Nuclear dis-
                          integration
                         Mouse
                                                   Mouse
                       850 mg/kg  Eye anomalies   337
                                                Negative
                                                                                                                    337
          THIOCARBAMATES
          FERBAM
Aspergillus  1000 ppm
niger spores
                          Onion root   240 ppm
                          tip
Morphological 337
mutants and
reverse muta-
tions
                          Chromosome
                          aberrations
              337
           Mouse
                       Negative
                                                                                                                    337
          NABAM

          THIRAM
                                                   Mouse                  Negative        337

                                                   Mouse                  Negative        337
                                                               250 mg/kg  Bone & heart    339
                                                               P.O. dur-  anomalies
                                                               ing organ-
                                                               ogenesis

-------
          TABLE VILL (CONT.) - MUTAGENICITY. AND TERATOGENICITY OF POTENTIAL ORGANIC  POLLUTANTS
           Agent
                           MUTAGENICITY
                Species
             Dose
             Effect
              Ref
                                                                               TERATOGENICITY
           Species	Dose
                                                                          Effect
              Ref
          THIRAM
           (cont.)
                                                     AMINE DERIVATIVES
                                                                              Hamster
                                                                              Rat
                                                                                          Congenital      187
                                                                                          malformations
                                                                               100 ppm    Negative
                                                                                          187
txi
VO
to
UREAS

DIURON

MONURON
           ABATE

           BIDRIN


           DEMETON


           DIAZINON
Barley
anther
500 & 1000
ppm  for 12
hrs
Abnormal
meiosis
453
                                                      PHOSPHATE ESTERS
                 Human        0.5 mg/1     Chromosome    411
                 lymphocytes                aberrations
                                                   Mouse

                                                   Mouse
                                                   Lamb

                                                   Chick


                                                   Chick


                                                   Rabbit


                                                   Hamster


                                                   Chick
Negative

Negative
                                                                                           Negative
337

337
                                                                                                                     299
                                                                                           Bone anomalies  187
                                                                                           Parrot  beak
                                                                                           Congenital
                                                                                           malformations
                                                  7 or 30
                                                  mg/kg  P.O. Negative

                                                  0.125  or
                                                  0.25 mg/kg Negative
                                                                                                     Congenital
                                                                                                     malformations
                                                                             244
                                                                339

                                                                339
                                                                187

-------
          TABLE VIII  (COOT.)  - MUTAGENICITY AND TERATOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
                             MUTAGENICITY
TERATOGENICITY
u>
Agent Species Dose Effect Ref
PHOSPHATE ESTERS
DICAPTHION Onion 0.5-6.0 Chromosome 337
root tip sq. cm. breaks
DICHLORVOS Onion 0.5-6.0 Chromosome 337
root tip sq. cm. breaks
EPN
GUTHION
IMIDAN
MALATHION
METHYL DEMETON
METHYL PARATHION
PARATHION Onion root 0.01,0.005, C-Mitosis 337
tip 0.0075%
PHOSPHAMIDON Barley 1000 & 500 Slight effect 453
anther ppm for 12 on meiosis
Species Dose Effect


Chick Congenital
malformations
Chick Congenital
malformations
Rabbit Negative
Chick 75 ppm/day Congenital
malformations
Chick Congenital
malformations
Mouse Cleft palate
Chick 0.1 mg/egg Congenital
malformations

Ref


187
187
187
187
244
187
187

                                       hrs
          TRITHION
                                                                             Mouse
           Cleft palate    187

-------
         TABLE VIII (CONT.) - MUTAGENICITY AND TERATOGENICITY OF POTENTIAL ORGANIC POLLUTANTS
         Agent
                         MUTAGENICITY
Species	Dose
Effect
Ref
                                                               TESATOGENICITY
Species	Dose	Effect
Ref
ro
vo
         FORMALDEHYDE    Mouse
         NAPHTHOL
          ETHYLMERCURY
          CHLORIDE       Triticum
                         root  tip
                          ALDEHYDES AND KETONES,

             20 mg/kg I.P. Negative      gg

                          PHENOLS AND QUINONES
                                                   Mouse       10 mg/kg   Eye anomalies   337
             0.5-1.
                                                      ORGANOMETALS
Mitotic       337
aberrations

-------
TABLE IX - SOURCES OF ORGANIC POLLUTANTS FOUND IN FRESH WATER




                                  AND




TABLE X - SOURCES OF POTENTIAL ORGANIC POLLUTMS OF FRESH WATER
     These tables contain chemicals which have been found in water




     (Table IX)  and chemicals which could potentially be found in




     water (Table X) according to sources given in the literature.




     The sources are ranked in accordance with a number of chemicals




     originating from each source and are categorized into the




     three groups:   industrial, agricultural and domestic.  Indus-




     trial sources  which did not specify the industry are listed




     separately.  Taking the two tables together we find that chem-




     ical plants contribute the highest number of chemicals which




     either have been found or could potentially be found in fresh




     water.   The agricultural source of pollution is one of pesti-




     cides and  the  domestic source of pollution consists of deter-




     gents.   In  terms of numbers of chemicals as well as classes of




     compounds,   industrial  sources contribute to fresh water pol-




     lution to a greater  extent than agricultural or domestic




     sources.

-------
TABLE IX - SOURCES OF ORGANIC POLLUTANTS FOUND IN FRESH WATER
                                        INDUSTRIAL
Pesticide Formulating Plants;
  Aldrin
  Chlordane
  ODD
  DDE
  DDT
Dieldrin
Diethylamine
Dimethylamine
Endrin
Ethylamine
Heptachor
Heptachloronorbornene
Hexachloronorbornadiene
Isodrin
Methylamine
Chemical Plants:
  Acetic acid
  Aniline
  Butyric acid
Def
Formic acid
Methane
Propionic acid
Pyrocatechol
Dye and Pigment Factories;
  Aniline
  Benzidine
Formic acid
Naphthylamine
Phenol
Propionic acid
Synthetic Rubber Plants;
  Diethylamine
  Dimethylamine
Ethylamine
Methylamine
Coal Tar Products Plants;
  Benzopyrene
  3,4-Benzopyrene
Cresol
Pyrocatechol
Gas Plants;
  Aniline
  Benzopyrene
Methane
Pyridine
                                               295

-------
TABLE IX  (CONT.) - SOURCES OF POLLUTANTS FOUND  IN WATER
 Coke Chemical Plants:
   Benzopyrene
3,4-Benzopyrene
                                                                 Pyridine
Petroleum Refineries;



   3,4-Benzopyrene
1,2,5,6-Dibenzanthracene
Methane
Shale Refineries:
   Benzopyrene
3,4-Benzopyrene
 Cosmetic Plants (soaps and perfumes):



   Phenyl ether                   Propionic  acid
                                                                 Phenol
Wood Distillation Plants;
   Acetic acid
Pyrocatechol
Rubber Plants:
   Aniline
Formic acid
Sugar Factory  (beet);



   Acetic acid






Acetaldehyde Plant;



   Methylmercuric chloride






Varnish Manufacturing;



   Butyric acid






Textile Mills;



   Acetic acid






Winery;



   Acetic acid
                                                296

-------
  TABLE IX (CONT.)  - SOURCES OF POLLUTANTS FOUND IN WATER

 Pyrolyzate Washing  (effluent);
    Pyrocatechol
 Industrial  (unspecified);
   ABS
   1,2-Benzanthracene
   3,4-Benzfluoranthene
   10,11-Benzfluoranthene
 11>12-Benzfluoranthene
 1,12-Benzperylene
 3,4-Benzpyrene
 Fluoranthene
 Indeno  (1,2,3-cd) pyrene
 Methylmercuric chloride
 Phenol
 Pyrene
   Aldrin
   Benzene hexachloride
   Chlordane
   DDD
   DDE
   DDT
   Dieldrin
       AGRICULTURAL
 2,4-D
 2,6-Dichlorobenzonitrile
 Endrin
 Endosulfan
 Fenac
 Heptachlor
Heptachlor epoxide
Isodrin
Lindane
Ronnell
Sllvex
Toxaphene
Detergents:
  ABS
                                          DOMESTIC
LAS
Waste Processing Plants:
  ABS
Phenol
                                               297

-------
 TABLE X - SOURCES OF POTENTIAL ORGANIC POLLUTANTS  OF FRESH WATER
Chemical Plants:
  Acetone
  Amyl alcohol
  Butyl alcohol
  Carbon  tetrachloride
  Chloroform
  Chloroaniline
  Cyclohexane
  Cyclohexene
  Dlbromo-heptafluoroisobutyl
     methyl  ether
  Diethylmercury
  Diisopropylamine
  Dimethylformamide
  DimethyIphenylcarbinol
       INDUSTRIAL


Dimethyl sulfide
Epichlorhydrin
Ethylene
Furfural
Maleic acid
Methyl alcohol
Methylethyl ketone
Methyl hexafluro-2-bromobuty-
  rate
Methyltetrafluoropropionate
MGK 264
Monoethanolamine
Nitrobenzene
Octafluoroisobutyl methyl
   ether
Phenylhydrazine
Propylene
Propylisome
Saponin
Sesame Oil
Sulfoxide
Tetrachloroethylene
Tetrachloroheptane
Tetrachlorononane
Trichloroethylene
Xylene
 Petroleum Plants:
   Acetonitrile
   Actusol
   Adiponitrile
   Benzonitrile
   Butyl mercaptan
   Chevron NI-0
   Chloronitrosocyclohexane
   Chlorophenol
Corexit 7664
Cyclohexane
Cyclohexanol
Cyclohexanone
Cyclohexene
E-314
F.O. 300B
Heptane
Holl-Chem 622
Jan-Solv-60
Lactonitrile
Oxydipropionitrile
Petrolite W-1439
Seasweep
Spill-X
Tetraethyl  lead
                                               298

-------
 TABLE X  (CONT.)  -  SOURCES  OF  POTENTIAL  ORGANIC  POLLUTANTS  OF  WATER
 Plastic Manufacturing:
   Butyl acetate
   Dichloromethane
   Diethylene glycol
   Ethylene
 Formaldehyde
 Furfural
 Hexachlorocyclopentadiene
 Hexachloroethane
 Perfluoroisobutenyl ethyl  ether
 PhenyIhyd r a z i ne
 Tetrachloroethane
 Trichlorobenzene
 Tar and Gas  Plants:
  Acridine
  Amyline
  Benzene
  Benzole acid
 Guaiacol
 Naphthalene
 Quinaldine
 Quinoline
 Rosolic acid
 Thiophene
 Toluene
Rubber  Plants;
  1,4-Butanediol
  Butylene
  Carbon tetrachloride
  Dichlorobutane
 1,2-Dichlorohexafluorocyclo-
  pentene-1
 Dichloromethane
 Isobutylene
 Isoprene
 PhenyIhydrazine
 Triethanolamine
Dye and Tanning Plants:
  Dimethylresorcinols
  Formaldehyde
  a-Naphthol
3-Naphthol
Pyrogallol
Qulnone
Ursol
Xylene
Ore Processing Plants;
   Acetamide
  Butyl xanthogenate
  Cresyl dithiophosphate
Diisopropyl dithiophosphate     Pine Oil
Octylphenol EO                  Terpineol
Oleoylmethyl tauride
Textile Plants;
  Benzene
  Chlorenanthic acid
Chloropelargonic acid
Chloroundecanoic acid
Naphthalene
                                             299

-------
TABLE X (CONT.) - SOURCES OF POTENTIAL ORGANIC POLLUTANTS OF WATER
Photographic Wastes;
  Butyl  acetate
  Hydroquinone
Pyrogallol
Quinone
Nylon Manufacturing;
  Adiponitrile
Hexamethylenediamine
Hexamethylenediamine adipate
Pulp Mill:
  Methyl mercaptan
4-(p-Tolyl)-l-pentanol
                                Tetrachlorocatechol
Organic Synthesis Plants;
  Formaldehyde
Phenylhydrazine
Pharmaceutical Manufacturing:
  Monoethanolamine
Streptomycin
General Industry  (unspecified);
  Acetone
  Alkyldimethyl benzylammonium
    chloride
  Alkyldimethyl chlorobenzyl-
    ammonium chloride
  4-Amino-m-toluene-sulfonic
    acid
  Butyl xanthogenate
  1,4-Butynediol
  Cetyldimethylethylaranonium
    bromide
Citric acid
Cresyl dithiophosphate
Diethylene glycol
Dinitrotoluene
Ethyl alcohol
Ethylene
Fur an
Isobutyl alcohol
Lactic acid
Methoxy polypropylene glycol
Morpholine
Phenylhydrazine
Picoline
Propyl alcohol
Propylene
Tetrahydrofurfuryl alcohol
Vetluzhsk Oil
                                              300

-------
TABLE X (CONT.) - SOURCES OF POTENTIAL ORGANIC POLLUTANTS OF WATER
Abate
Acrolein
Acrylonitrile
Algibiol
Alkydimethyl benzylammonium
  chloride
Alkydimethyl chlorobenzyl
  ammonium chloride
Amitrole
Anisole
Apholate
Aramite
Atrazine
Azodrin
Baygon
Bayluscide
Benzethonium chloride
Bidrin
Binapacryl
Bromophos
Butane
Butoxy polypropene glycol
Butyl mesityl oxide oxalate
C 56
Captan
Carbaryl
Carbathion
Carbophenothion
Cetyldimethylethylammonium
  bromide
Chloroaniline
Chlorobenzilate
Chlorpropham
Chlorthion
Ciodrin
      AGRICULTURAL
Coumaphos
Dalapon
Dasanit
Dazomet
2,4-DB
DCU
Delrad
Demeton
2,4-DEP
Diazinon
Dicapthon
Dichlone
Dichlorobenzene
Dichlorvos
Dicofol
Diethyl dithiophosphoric acid
Diethyl maleate
Diethyl toluamide
Dilan
Dlmethrin
Dimethyl carbate
Dimetilan
Dinitrocresol
2,4-Dinitrophenol
Dinobuton
Dinoseb
Dioxathion
Diphacinone
Diquat
Disulfoton
Diuron
Drione
Endothall
EPN
              301
Ethion
Ethyl hexanediol
Fenthion
Fenuron
Ferbam
Folex
Furfural
Gardona
Guthion
Hemp a
Hercules 9699
Hexachlorobutadiene
Hexachloroethane
Imidan
IPC
Isolan
Isopropylamine
Kepone
Lethane 384
Malathion
Matacil
MCPB
Menazon
3-Mercaptodiethylamine
Mesurol
Metepa
Metham
Methoxychlor
S-Methyl-N-(methylcarbamoyloxy)
  thioacetamidate
Methyl parathion
Methyl trithion
Mevinphos
MGK Repellent 11

-------
TABLE X (CONT.) - SOURCES OF POTENTIAL ORGANIC POLLUTANTS OF WATER
MGK Repellent 326
Mirex
Mo bam
Monuron
Nab am
Naled
a-Naphthol
0-Naphthol
Nemagon
Neotran
Nicotine
Ovex
Oxydemetonmethyl
Paraoxon
Paraquat
Perthane
Phorate
Phosphamidon
        AGRICULTURAL
          (continued)
Phostex
Pinene
Piperonyl butoxide
Pival
Pyrethrins
Rotenone
Ruelene
Sarin
Schradan
SD 7438
SD 8530
Sesone
Shell D50
Simazine
Soricide tetraminol
Strobane
Strychnine
Sumithion
Tabutrex
2,3,5-TBA
2,3,6-TBA
Temik
Tepa
TEPP
Tetrachlorobenzene
Tetrachloroethane
Thionazin
Thiram
Tranid
Triaram
Trichlorfon
Trichloronate
Warfarin
Zectran
Zineb
Ziram
                                         DOMESTIC
  Alkyldimethyl benzylairanonium
    chloride
  Alkyldimethyl chlorobenzyl
    ammonium chloride
  Blast
  Butylbiphenyl sulfonate
  Cetyldimethylethylammonium
    bromide
  Decylbenzene sulfonate
  3,9-Diethyl-tridecyl-6-
    sulfonate
  Dodecylbenzene sulfonate
7-Ethyl-2-methyl-undecyl-4-
   sulfate
Ethyl phenylphenol sulfate
Fatty sorbitan
Isorpopylnaphthalene sulfonate
Laurie diethanolamide sulfonate
Lauryl alcohol EO
Lauryl alcohol sulfate EO
Lauryl glyceryl ether sulfonate
Lauryl imidazoline
Lauryl sulfate
              302
Monoethanolamine
Nonyl Phenol EO
Oleyl alcohol EO
Phenylhydrazine
Polyethyleneglycolalkylphenol
  esters
Quaternary ammonium chloride
Quaternary pyridinium
Stearoyl EO
Sterinol
Sterox

-------
TABLE XI - REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS FOUND IN
     FRESH WATER PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED
     ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC EFFECTS IN MAN
     This table presents the reported maximum no-effect concentra-
     tions of organic chemicals when administered chronically to
     mammals or when tested  for organoleptic effects in man.  Ex-
     cept in a few instances, the sources for the information are
     from the Russian literature.  Approximately 80% of the data
     is derived from organoleptic effects using human subjects.

-------
TABLE XI - REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS FOUND IN FRESH WATER
             PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED ON A CHRONIC BASIS

                         OR TESTED FOR ORGANOLEPTIC EFFECTS IN MAN
                                   ALKANES  AND ALKENES
                                                                 Limiting Index
Reference
13
354
355
355
13
194,190,
228,191
13

429,430,
431
214,438,
459
48
357
178,179
274,275
219,252
228
438
357
228,185
300
Agent
Unsubstituted
butylene
cyclohexane
cyclohexene
ethyl ene
Isobutylene
isoprene
propylene
Halogenated
aldrin

allyl chloride
butane, poly-
chloro
carbon tetra-
chloride
chlordane
chloroprene
chlorocyclo-
hexane
0.2
0.1
0.2
0.2
0.5
0.005
0.5

0.002
0.017*
0.00025*
0.31
0.01-0.02
0.3
5.0
0.003
0.00025
0.1
0.05
Location
reservoir water
well water
"
"
reservoir water
"
ii

reservoir water
surface water for
public water
supplies
reservoir water
finished water
reservoir water
"
"
surface water
for public water
supplies
finished water
reservoir water
M
 *  From American Maximum permissible  concentration data.

                                            303
                                                                 sanitary-toxicological
                                                                 organoleptic
                                                                  sanitary-toxicological
                                                                  organoleptic


                                                                  organoleptic
                                                                  sanitary-toxicological
                                                                  organoleptic
                                                                  organoleptic
                                                                  sanitary-toxicological

-------
  TABLE  XL (CONT.) -
REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS FOUND IN
FRESH WATER PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED
ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC EFFECTS IN MAN
               ALKANES AND ALKENES
                                                                  Limiting Index
                                                                  organoleptic
Reference

132,228
184
206,207,
228,230
380


381


414
214,438

214,438

357
214,438

214,438

274,275

284

415,438
214,438
357
Agent
Halogenated
dichlorobutane
dichlorobutene
dichlorocyclo-
hexane
1,2-dichloro-
hexaf luoro-
1-cyclohexene
1,2-dichloro-
hexaf luoro-
cyclopentene-1
dichlorome thane
dieldrin

end r in

freon 253
heptachlor

heptachlor
epoxide
hexachlorobuta-
diene
hexachloropenta-
diene
hexachloroethane
lindane

mg/1
0.05
0.05
0.02
0.4


0.4


7.5
0.017*

0.001*
0.0001*
0.1
0.018*

0.018*

0.01

0.001

0.01
0.056*
0.005*
Location

reservoir water
"
"
„


it


"
surface water for
public water supply
ii
finished water
reservoir water
surface water for
public water supply
..

reservoir water

..

"
surface water for
public water supplie
finished water
                                                                  sanitary-toxicological
                                                                  organoleptic
                                                                  sanitary-toxicological
                                                                 organoleptic
* From American maximum permissible concentration data.
                                            304

-------
  TABLE XI  (CONT.) -  REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS FOUND IN

                      FRESH WATER PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED

                      ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC EFFECTS IN MAN

                                     ALKANES AND ALKENES
  Reference
  213
  415
  228

  359
  359
Agent

Halogenated

plnene, poly-
chloro

tetrachloro-
ethane

tetrachloro-
heptane

tetrachloro-
nonane
mg/1
0.2
0.01
0.2

0.0025
0.003
359
359
359
214,438
357
264,228
tetrachloro-
pentane
tetrachloro-.
propane
tetrachloro-
undecane
toxaphene

trichloro-
ethylene
0.005
0.01
0.007
0.005*
0.0025*
0.5
Location
reservoir water
                                              surface water for
                                              public water supply
                                              finished water

                                              reservoir water
Limiting Index
sanitary-toxicological
                     organolaptic
                                                     organoleptic
  206,207,
  228,230

  352,228

  393
Nitro Compounds

chloronitroso-
cyclohexane
0.005
nitrocyclohexane  0.1

nitromethane      0,005
reservoir water
organoleptic
                                   based on possibility of
                                   forming chloropicrin
  178,179

  227,228,
  286
allyl alcohol     0.1

butyl alcohol     1.0
                                          ALCOHOLS
              reservoir water
* From American maximum permissible concentration data.
                                              305
                     organoleptic

-------
 TABLE XI (CONT.)  - REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS FOUND IN

                    FRESH WATER PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED

                    ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC EFFECTS IN MAN

                                       ALCOHOLS
 Reference

 197

 197

 228,353

 210

 313

 376


 313

 466


 256,257

 227,228
 286

 227,228



 210

 205,256

 233

 262

 233

 321,322,

 320
462

85

86
 Agent            mg/1

 1,4-butanediol    5.0

 1,4-butynediol    1.0

 cyclohexanol     0.5

 dichlorohydrin    1.0

 diethylene  glycol 1.0

 dimethylphenyl-   0.05
 carbinol

 ethylene  glycol   1.0

 ethylene  glycol   1.0
 monoethyl ether

 heptyl  alcohol    0.005

 isobutyl  alcohol  1.0


 methyl  alcohol



 monochlorohydrin  0.7

 nonyl alcohol     0.01

 pine oil

 streptomycin

 terpineol
              Location
              reservoir water
tetrahydro-
furfuryl alcohol
0.2

0.1

0.05

1.0
                  0.5
Aliphatic

diazobutylamine   0.07

diethylanolamine  1.0

                  0.8
                                        AMINES
              reservoir water
                                           306
 Limiting Index

 sanitary-toxicological
                                   organoleptic

                                   sanitary-toxicological
                                   dissolved 0  and BOD
organic matter content,
BOD, & dissolved 0.


organoleptic

sanitary-toxicological

organoleptic

sanitary-toxicological

organoleptic

sanitary-toxicological
sanitary-toxicological

BOD

organoleptic

-------
TABLE  XI  (CONT.) -  REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS FOUND IN

                    FRESH WATER PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED
                    ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC EFFECTS IN MAN

                                          AMINES
Reference

176

122

88,89

117

43


44


93

116

328

114


92,93

85

227,228,
461
217,455

347




138



467
Agent             mg/1

diethylamine      2.0

diisopropylamine  0.5

dimethylamine     0.1

ethylamine
hexame thylene-
diamine

hexame thylene-
diamine adlpate
0.5

0.01


1.0
hydrazine hydrate 0.01

isopropylamlne    2.0

methylamine
 g-mercaptodi-
ethylamine
1.0

0.1
phenylhydrazine   0.01

triethanolamine   5.0

ursol             0.1


Aromatic

aniline           0.1

dichloroaniline   0.05
Quarternary

alkyldimethyl-
b enzylammonium
chloride
0.5
              Location
              reservoir water
quarternary       0.05
ammonium chloride
drinking water
              reservoir water
                     Limiting  Index

                     sanitary-toxicological
                     organoleptic

                     sanitary-toxicological
                     organoleptic

                     sanitary-toxicological

                     organoleptic


                     sanitary-toxicological

                     BOD

                     organoleptic
              reservoir water      sanitary toxicological

                     "             organoleptic
organoleptic
                                                                 sanitary-toxicological
                                            307

-------
   TABLE XI (CONT.) -  REPORTED MAXIMUM CONCENTRATION  OF  ORGANIC  CHEMICALS  FOUND IN
                       FRESH WATER  PRODUCING  NO  EFFECT IN MAMMALS WHEN ADMINISTERED
                       ON  A CHRONIC BASIS  OR  TESTED  FOR ORGANOLEPTIC  EFFECTS  IN MAN
                                           AMINES
Reference
365
454
196

249
214,438
423
227,464

228
195
228
228
214,438
272
303
198,199
129
Agent
Nitriles
acetone cyano-
hydrin
aery lonitr lie
adiponitrile
Heterocycllc
cyanuric acid
2,5-lutidine
picoline
pyridine
Carboxylic
acetic acid
acrylic acid
benzoic acid
butyric acid
2,4-D


dalapon
2,4-DB
mg/1 Location
0.001 reservoir water
2.0 "
0.1

6.0 reservoir water
0.056 "
0.05
0.2
ORGANIC ACIDS

based on organic reservoir water
matter content,
BOD, & dissolved 0
0.5
based on organic "
matter content,
BOD, & dissolved 0
it ii
0.1* surface water for
public water supply
1.0 reservoir water
3.0
2.0
1.0
Limiting Index
sanitary toxicological
M
it

organoleptic
sanitary-tox:i.cological
n
ti

general sanitary

general sanitary
n

organoleptic
M
n
sanitary- toxicological
* From American maximum permissible concentration data.
                                               308

-------
 TABLE XI (CONT.)  -  REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS FOUND IN

                    FRESH WATER PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED

                    ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC EFFECTS IN MAN

                                     ORGANIC ACIDS
Reference   Agent
                  mg/1
              Location
 227,228



 227,228

 229

 232

 254,258

 214-438
formic acid
Limiting  Index
based on organic reservoir water   general sanitary
matter content,
BOD, & dissolved 0
lactic acid

maleic acid       1.0

maleic anhydride  1.0

phthalic acid     0.5

2,4,5-T           0.1*
                                            surface water for
                                            public water supply
                                   organoleptic
                                   sanitary-toxicological
            Sulfonics

168         alkyl benzene     0.5
            sulfonate

282         p-chlorobenzene   5.0
            sulfonate, Na

281,292     chlorophenyl      0.2
            chlorobenzene
            sulfonate
                                reservoir water
                                   sanitary-toxicological
                                                     organoleptic
                                        ESTERS
46

346


325


245

27

134,135
butyl acetate     0.3

diethyl maleate   1.0
dimethyltere-
phthalate
1.81
dioctylphthalate  2.0

methyl benzoate   0.001

vinyl acetate     0.2-0.25
              reservoir water
              inland waters

              reservoir water
  *  From  American maximum permissible  concentration  data
organoleptic

conjunctival irritation
tests
                                                                 sanitary-toxicological-
                                                                 organoleptic
                                           309

-------
 TABLE XL (CONT.) - REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS  FOUND  IN
                    FRESH WATER PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED
                    ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC EFFECTS  IN MAN
                                    AMINE DERIVATIVES
                                                                 Limiting Index


                                                                 depends on watercourse
                                                                 organoleptic
                                                                 sanitary-toxlcological
                                                                           M

                                                                 organoleptic
                                                                 sanitary-toxicological
                                                                 organoleptic
                                                                 sanitary-toxicological


                                                                 organoleptic
Reference

227,350
121
456
392
99
99
99
94

123
5
5

278
276
277
278
Agent
Amides
caprolactam
dicyanodiamide
d ime thyl f o rmamid e
methacrylamide
sulfadimesine
sulfaguanidine
sulfanilamide
sulfathiazole
Carbamates
carbaryl
chloroprophatn
IPC
Thiocarbamates
carbathion


dimethyldithio-
mg/1 Location

1-2
10.0 reservoir water
10.0 "
0.1 "
1.0
0.01
0.5
0.1 "

0.1 reservoir water
1.0
0.2

0.0256 reservoir water
0.02 "
0.026
0.1 "
13
carbamate, NH,

Ureas
urea
10.0
reservoir water
organoleptic
                                            310

-------
TABLE XL (CONT.) -
119


118


7

113


112,227,
228

202

6,101,
228

101

227,239

469
                    REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS FOUND 'IN

                    FRESH WATER PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED

                    ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC EFFECTS IN MAN

                                    PHOSPHATE ESTERS
Reference
202
344
233,234
223,227
218
Agent
acetophos
chlorophos
cresyl dithio-
phosphate
demeton
diethylchloro-
mg/1
0.03
0.05
0.001
0.01
0.02
Location Limiting Index
reservoir water organoleptic
it ti
it
" organoleptic
11 ii
            thiophos

            dlethyldithio-     0.2
            phosphoric  acid

            diisopropyl di-    0.02
            thio  phosphate,  K
            dimethoate
0.03
            dimethyldithio-    0.01
            phosphoric  acid
           malathion
0.05
           methylacetophos    0.03

           methyl-demeton     0.01


           methyl parathion   0.02

           parathion          0.003

           tributylphosphate  0.01
                     sanitary-toxicological

                     organoleptic
                                   sanitary-toxicological

                                   organoleptic
15

227,228
            acelaldehyde

            acetone
                                ALDEHYDES AND KETONES
0.2
reservoir water
based on content
of organic matter,
BOD, & dissolved 0,
organoleptic

general sanitary
                                           311

-------
  TABLE XI (CONT.) - REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS FOUND  IN

                     FRESH WATER PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED

                     ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC EFFECTS IN MAN


                                   ALDEHYDES AND KETONES
                                                                  Limiting Index


                                                                  sanitary-toxicological

                                                                  self-clarification
                                                                  processes

                                                                  sanitary-toxicological

                                                                  organoleptic

                                                                  sanitary-toxicological


                                                                  organoleptic
Reference
377
136
292
422
227,228,
287
220
227,422
283
245
14
192,193,
252
343
37,364

132,228
132,228
216,227,
228
Agent mg/1 Location
acetophenone 0.1 reservoir watei
acrolein 0.01 "
cyclohexanone 0.2 "
1.0 "
formaldehyde 0.5 "
furfural i.o "
methylethylketone 1.0 "
ETHERS
anisole 0.05 reservoir water
dibutyl phthalate 2.0 "
diethyl ether 0.3 "
dimethyldioxane 0.005 "
furan 0.2 "
perfluoroiso- 0.3 "
butenyl ethyl
ether
polyethylene-
glycolalkyl-
phenyl ethers
OP-7 0.4 "
OP- 10 1.5 "
saponin 0.2 "
                                                                  organoleptic

                                                                  sanitary-toxicological
                                                                 organoleptic
                                                                 sanitary-toxicological
319,320
tetrahydrofuran   0.5
                                           312

-------
TABLE XL (CONT.) -'REPORTED MAXIMUM CONCENTRATION OF  ORGANIC  CHEMICALS  FOUND  IN
                   FRESH WATER PRODUCING NO EFFECT  IN MAMMALS WHEN ADMINISTERED
                   ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC  EFFECTS  IN MAN

                               UNSUBSTITUTED AROMATICS
                                                                Limiting  Index
                                                                 sanitary-toxicological
Reference
307
227,228
455
333
333
410
410
45
211,228
120
420
316,317
104
271
455
455
401
204
103,227
460,461
111,228
Agent
benzene

naphthalene
phenanthrene
pyrene
o - ami no ph eno 1
p-aminophenol
benzoquinone
dioxime
Cheremkhovsk tar
dichlorophenol
dimethyl-
re sore ino Is
2,4-dinitrophenol
diphenylolpropane
hydroquinone
a-naphthol
6-naphthol
mg/1 Location
0.25 reservoir water
0.5
0.05
0.4 reservoir water
0.4
PHENOLS AND QUINONES
0.01 reservoir water
0.05 "
0.1 "
0.002
0.002 "
0.07
0.03 "
0.01
0.2-0.4 "
1.0
0.5
1.4-naphthoqu±none 0.1 "
nltrotoluol
phenol
qulnone
Vetluzhsk oil
0.01-0.2
0.001 "
0.2
0.02 "
                                                                 organoleptic
                                                                 sanitary-toxicological
                                                                 organoleptic
                                                                 sanitary-toxicological
                                                                 organoleptic
                                                                organoleptic
                                           313

-------
   TABLE XI (CONT.)  - REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS FOUND IN
                      FRESH WATER PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED
                      ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC EFFECTS IN MAN

                                    AROMATIC  DERIVATIVES
Reference

186
237,238
186,237
418
214,438
227,228
357
347
418
143
143,228
214,438
101
98
75
108
143
143,227
9
435
Agent
Halogenated
m-chloroaniline
p-chloroaniline
chlorobenzene
DDT
dichloroaniline
dichlorobensSene
hexachloro-
benzene
methoxychlor
nitrochloro-
benzene
tetrachloro-
benzene
trichloro-
benzene
Nitro compounds
nitrobenzene
xylene
mg/1
0.2
1.0
0.2
0.02
0.042*
0.2
0.5*
0.05
0.002
0.03
0.05
0.035*
0.05
20.0
0.03
0.02
0.03
0.03
0.2
0.05
Location

reservoir water
i>
ir
it
surface water for
public water supply
reservoir water
finished water
reservoir water
it
ii
M
surface water for
public water supply
reservoir water
streams
reservoir water
M
ii
ii
reservoir water
it
Limiting Index

sanitary-toxicological
organoleptic
sanitary-toxicological
it
organoleptic-toxicological
organoleptic-toxicological
organoleptic
ii
sanitary-toxicological
sanitary-toxicological
organoleptic
sanitary-toxicological
organoleptic
it
organoleptic
n
* From American maximum permissible concentration data.
                                              314

-------
 TABLE XI (CONT.)  -  REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS FOUND IN

                    FRESH WATER PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED

                    ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC EFFECTS IN MAN

                                   AROMATIC DERIVATIVES
Reference   Agent
                   mg/1

463
296
375
2
3,228
Aryl alkanes
ethylbenzene
methylstyrene
propylbenzene
toluene

.fcafc" - .-
0.01
0.1
0.2
1.0
0.5
Location
                                            reservoir water
Limiting Index
                                                     organoleptic
                         MERCAPTANS AND OTHER SULFUR ORGANICS
233,234


227,228,
424

201

343
butyl xantho-     0.0001
genate

carbon disulfide  1.0
dimethyl  sulfide  0.03

thiophene        2.0
reservoir water
organoleptic
458         diethylmercury    0.0001

458         ethylmercuric     0.0001
            chloride

227,228     tetraethyl lead   0.0

371         tetraethyl tin    0.0002
                                       ORGANOMETALS
                                reservoir water
                     sanitary-toxicological
308
308
butoxy propylene  2.0
glycol

methoxy polyprop- Q.5
ylene glycol
                                         POLYMERS
reservoir water
                                                                 organoleptic
                                                                 sanitary-toxicological
                                           315

-------
 TABLE XI  CCONT.) -  REPORTED MAXIMUM CONCENTRATION OF ORGANIC CHEMICALS FOUND IN

                    FRESH WATER PRODUCING NO EFFECT IN MAMMALS WHEN ADMINISTERED

                    ON A CHRONIC BASIS OR TESTED FOR ORGANOLEPTIC EFFECTS IN MAN

                                         POLYMERS
Reference   Agent
212


209


408

425
methy1-
siliconate, Na
                  mg/1
1.5
poly(ethylhydro-  8.0
siloxane)

polymethacrylate  2.0

polystyrene,      0.5
cationic
              Location
                     Limiting Index
reservoir water      organoleptic
              potable water
                     sanitary-toxicological
                                           316

-------
TABLE XII - ACUTE TOXICITY RANKING OF ORGANIC CHEMICALS FOUND IN FRESH




   WATER AS DETERMINED BY LD   IN MAMMALS USING ORAL ADMINISTRATION
     This table ranks acute toxicity of organic chemicals found in




     water based on LD^ data to show relative acute toxic effects.




     Chlorinated hydrocarbons show intense acute toxicity and all




     can be considered to be derivatives of norbornene.   With the




     exception of methyl mercuric chloride they are the  most toxic




     compounds now found in fresh water.  Heptachlor and Chlor-




     dane also have the same chlorinated norbornene nucleus but




     are not as toxic.  Apart from these compounds, the  other




     most highly acute toxic compounds do not share common struc-




     tural features but most of them contain chlorine atoms.  (See




     pages 44 to 46 for a more detailed discussion of this table.)

-------
TABLE XII - ACUTE TOXICITY RANKING OF ORGANIC CHEMICALS FOUND IN FRESH
            WATER AS DETERMINED BY LD-- IN MAMMALS USING ORAL
            ADMINISTRATION
                          0-99 mg/kg
1.   Endrin
2.   Methyl mercuric chloride
3.   Isodrin
4.   Aldrin
5.   Endosulfan
6.   Toxaphene
                         100-199 mg/kg
7.  Lindane
8.  Pentachlorophenol
9.  Heptachlor
10.Sodium pentachlorophenate
11.Methyl mercuric chloride
                         200-299 mg/kg
12. DDT
13. Dimethylamine
14. 2,6-Dichlorobenzonitrile
15. Def
16. 2,4,5-T
17. 2,4-D
18. 3-Isomer BHC
19. Chlordane
                         300-399 mg/kg
20. Benzene hexachloride
21. Ethylamine
22. DDD
23. o-Aniline
24. Aniline
                         400^499 mg/kg
25. Silvex
                         500-599 mg/kg
26. tp-ABS
27. Nitrochlorobenzene
28. Diethylamine
                               317

-------
 TABLE XII (CONT.)  - ACUTE TOXICITY RANKING OF ORGANIC CHEMICALS FOUND
                     IN FRESH WATER AS DETERMINED BY LD Q IN MAMMALS
                     USING ORAL ADMINISTRATION
                         600-799 mg/kg
29.  Ronnell
 30.   ABS  Linear
 31.  DDE
                          800-999 mg/kg
                         1000-2499 mg/kg
 32. ABS

•33. o-Cresol
• 34.   Fenac

•35.   p-Cresol
                        2500-5000 mg/kg
 36. Acetic  acid

•37. Pyrocatechol
•37.   Formic  acid
                        >5000 mg/kg
 38.  Butyric  acid
• 39.   Pyrene
                                318

-------
TABLE XIII - ACUTE TOXICITY RANKING OF POTENTIAL ORGANIC POLLUTANTS OF
   WATER AS DETERMINED BY LD50 IN MAMMALS USING ORAL ADMINISTRATION
     This table ranks the acute toxicity of organic compounds which
     are considered to be potential pollutants of fresh water.  Of
     the most toxic compounds,  15 out of 23 are phosphate esters.
     The remaining 8 compounds  are substituted pyridines (nicotine
     and picoline), carbamates  (Isolan and Temik),  an anticoagulant
     (diphacinone), acrolein,  the organometallic tetraethyltin, and
     cyanohydrin.   Among the remaining more toxic compounds (1 to
     100 mg/kg),  the organophosphorus compounds make up the largest
     grouping with 20 pesticides  falling within this category.

-------
 TABLE XIII - ACUTE TOXICITY RANKING OF POTENTIAL ORGANIC POLLUTANTS AS
              DETERMINED BY LD Q IN MAMMALS USING ORAL ADMINISTRATION
                               0-49  mg/kg
 1.   Tepp
 2.   Temik
 3.   Phorate
 4.   Picoline
 5.   Dasanit
 6.   Diphacinone
 7.   Nicotine
 8.   Disulfoton
 9.   Deraeton
10.   Acetone cyanohydrin
11.   Parathion
12.   Paraoxon
13.   Warfarin
14.   Mevinphos
15.   Thionazin
16.   Schradan
17.   Isolan
18.   Carbophenothion
19.   EPN
20.   Guthion
21.   Tetraethyl tin
22.   Acrolein
23.   2,4-DEP
24.   Phosphamidon
25.   Methyl parathion
26.   Chlorfenvinfos
27.   Malaoxon
28.   Coumaphos
29.   Ethion
30.   Dichlorvos
31.   Bidrin
32.   Azodrin
33.   Tranid
34.   Adiponitrile
35.   Dioxathion
36.   Mustard Gas
37.   Dinitrocresol
38.   Zectran
39.   Pyrogallol
40.   Dimetilan
41.   Acetophos
42.   Dimethoate
43.   p-Dinitrobenzene
44.   Matacil
45.   Methylamine
46.   2,4-Dinitrophenol
47.   Malathion
48.   Trichloronate
49.   Endothall
50.   Tepa
51.   Methylacetophos
52.   Oxydemetonmethyl
                                     319

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 TABLE XIII (CONT.) - ACUTE TOXICITY RANKING OF POTENTIAL ORGANIC POLLUTANTS AS
                      DETERMINED BY LD5Q IN MAMMALS USING ORAL ADMINISTRATION
                               50-99 mg/kg
 53.   Methyl demeton
 54.   Dinoseb
 55.   Diethyl mercury
 56.   Binapacryl
 57.   Cetyldimethyethylammonium bromide
 58.   Mesurol
 59.   Hercules 9699
 60.   Freon  253
 61.   Allyl Alcohol
 62.   Ciodrin
 63.   Streptomycin
 64.   Diazinon
 65.  Phenylhydrazine
 66.  Acrylonitrile
 67.  Dursban
 68.  Baygon
 69.  Hexachlorobutadiene
 70.  B-Naphthol
 71.  Paraquat
 72.  Lethane
 73.  Dichlorohydrin
 74.  Kepone
 75.  Apholate
                              100-199 ms/kg
 76*   1,4-Butynediol
 77.   Ethylene dibromide
 78.   Imidan
 79.   Mobam
 80.   Carbaryl
 81.   Furfural
 82.   Quinone
 83.   Rotenone
 84.  a-Naphthol
 85.  Carbon Bisulfide
 86.  Monochlorohydrin
 87.  Metepa
 88.  Epichlorhydrin
 89.  Perfluoroisobutenyl ethyl ether
 90.  Fenthion
                              200-299 mg/kg
 91.   HRS-1422
 92.   Pyrethrins
 93.   Quarternary pyridintum
 94.   Strobane
 95.   SD-8530
 96.   Ethyl iitercuric chloride
 97.   Methyl perfluoromethylacrylate
 98.   Diraethylamine
 99.   Sterinol
100.   Acrylic acid
101.  Omite
102.  Naled
103.  Sumithion
104.  m-Chloroaniline
105.  Phostex
106.  Carbathion
107.  1,2-Dichlorohexafluoro-cyclopentene-1
108.  Pival
109.  Dicapthon
110.  Metham
                                      320

-------
 TABLE XIII (CONT.) _ ACUTE TOXICITY RANKING OF POTENTIAL  ORGANIC  POLLUTANTS AS
                      DETERMINED BY LD5Q IN MAMMALS USING  ORAL ADMINISTRATION
                              300-399 mg/kg
111.  p-Chloroaniline
112.  Methyl hexafluoroisobutyrate
113.  2,3,5-TBA
114.  Mirex
115.  Methylomethacrylamide
116.  Dazomet
117.  Hydroqulnone
118.  Nitrophenol
119.  Nitrotoluol
120.  AlkydimethyIbenzyl ammonium chloride
121.  3-Mercaptodiethylamine
122.  Thlram
123.  Pinene, polychloro
124.  Chloronitrosocyclohexane
125.  2-Ethylbutylamine
                              400-499 mg/kg
126.  Ethylamine
127.  Diquat
128.  Trichlorfon
129.  3,9-Diethyltridecyl-6-sulfate
130.  Tetrachloropentane
131.  m-Nitroaniline
132.  p-Nitroaniline
133.  Triethylamine
134.  Ruelene
135.  Methacrylamide
136.  Dilan
137.  Tetrachloroheptane
138.  Dichlorocyclohexane
139.   Dichlorobenzene
140.   Sulfoxide
141.   Diethylamine
142.   Dibutylamlne
                              500-599 me/kg
143.  Diisopropylamine
144.  Chlorthion
145.  Dimethyldithiocarbamate
                              600-699 mg/kg
146.  Hexachlorocyclopentadiene
147.  Tetrachloropropane
148.  Isopropylamlne
149.  DDA
150.  Butyl xanthogenate
151.  Vetuzhsk Oil
152.  Sesone
153.  7-Ethyl-2-methylundecil-4 sulfate
154.  Ethylene dichlorlde
155.  3,4-Dichloroaniline
156.  MCPB
                                      321

-------
 TABLE XIII (CONT.) - ACUTE TOXICITY RANKING OF POTENTIAL ORGANIC POLLUTANTS AS
                      DETERMINED BY LD Q IN MAMMALS USING ORAL ADMINISTRATION
                              700-799 mg/kg
157.  Phenanthrene
158.  Nitrobenzene
159.  Dodecyldiphenyl ether sulfonate
160.  Tetrachloroethane
161.  Quaternary ammonium chloride
162.  Dichloroethane
163.  Formaldehyde
164.  Delrad
                              800-899 mg/kg
165.  Nitroethane
166.   Nitromethane
167.   Folex
168.   Tetrachlorononane
                              900-999 mg/kg
169.  Butane
170.  Methylhexafluoro-2-bromobutyrate
                             1000-2499 mg/kg
171.   Diethyldithiophosphoric acid            191.
172.   Dimethyl resorcinols                    192.
173.   Lauryl sulfate                          193.
174.   IPC                                     194.
175.   Zineb                                   195.
176.   Abate                                   196.
177,   Octafluoroisobutyl methyl ether         197.
178.   Menazon                                 198.
179.   Tetrachlorobenzene                      199.
180.   Chlorobenzilate                         200.
181.   Morpholine                              201.
182.   Heptafluoroisobutylene methyl  ether      202.
183.   Phthalic acid                           203.
184.   Morestan                                204.
185.   Amitrole                                205.
186.   Gardona                                 206.
187.   Dimethyl  carbate                        207.
188.   Anisole                                 208.
189.   Dibromoheptafluoroisobutyl methyl  ether  209.
190.   Ethylenediamine                         210.
      Lauryl alcohol EO
      Lauryl alcohol sulfate EO
      Tributyl phosphate
      Dibutyl phthalate
      1,4-Butanediol
      Quinaldine
      Cyclohexanol
      o-Nitroaniline
      Diethyl maleate
      Cheremichousk Tar
      Diethanolamine
      Dichlone
      Polystyrene, cationic
      Chloropropham
      2,3,6-TBA
      Monoethanolamine
      2-Ethylhexyl sulfate
      Thanite
      Bromophos
      Nonyl phenol EO
                                      322

-------
  TABLE XIII (CONT.) - ACUTE TOXICITY RANKING OF POTENTIAL ORGANIC POLLUTANTS AS
                       DETERMINED BY LD5Q IN MAMMALS USING ORAL ADMINISTRATION
                             1000-2499 mg/kg
                                 continued
 211.  Vinyl acetate
 212.  DimethyIphenyl carbinol
 213.  Chloroform
 214.  Octylphenol  EO
 215.  Chlorenanthic acid
 216.  Lauryl glyceryl  ether sulfonate
 217.  Dioctyl succinate sulfonate
 218.  Isopropyl naphthalene sulfonate
 219.  Diethyltoluamide
 220.  Ethylphenylphenol sulfonate
                  221.  Ovex
                  222.  Sesame Oil
                  223.  Alkyldimethylchlorobenzyl  ammonium
                                 chloride
                  224.  Decylbenzene  sulfonate
                  225.  Atrazine
                  226.  Prometryne
                  227.  Butylphenylphenol sulfonate
                  228.  Naphthalene
                  229.  Dodecylbenzene sulfonate
                  230.  Aramite
                              2500-5000 mg/kg
 231.  MGK Repellent 11
 232.  2,5-Dichloroaniline
 233.  Ethyl hexanediol
 234.  Hempa
 235.  Oleyl alcohol
 236.  Alkyl sulfonate
 237.  Laurie diethanolamide
 238.  Butyl Alcohol
 239.  MGK 264
 240.  Chloropelargonic acid
 241.  Methyl benzoate
 242.  Hexachloroethane
 243.  Captan
 244.  Butyl acetate
 245.  Lauryl imidazoline.
 246.  Dimethyl sulfide
247.  Propyl  alcohol
248.  Butybiphenyl'sulfonate
sulfonate
249.  Diuron
250.  Monuron
251.  Methyl siliconate
252.  Methyl ethyl ketone
253.  Ferbam
254.  Perthane
255.  Dalapon
256.  Oleoylmethyl tauride
257.  Xylene
258.  Cyclohexane
      DCU
      Propylisome
      Methylstyrene
      Simazine
      Ethyl Acetate
      Dimethrin
      Methyl tetrafluoropropionate
                 259.
                 260.
                 261.
                 262.
                 263.
                 264.
                 265.
                 266.  Methoxychlor
                                      323

-------
 TABLE XIII  (CONT.) - ACUTE TOXICITY RANKING OF POTENTIAL ORGANIC POLLUTANTS
                      DETERMINED BY LD  . IN MAMMALS USING ORAL ADMINISTRATION
                               >5000 mg/kg
267.  Ethylene gylcol
268.  MGK Repellent 326
269.  Benzene
270.  Dichloromethane
271.  Carbon tetrachloride
272.  Neotran
273.  Trichloroethylene
274.  Chloroundecanoic acid
275.  Sulfanilamide
276.  Piperonyl butoxide
277.  Fenuron
278.  Toluene
279.  Butyl mesityl oxide
280.  Tabutrex
281.  Triethanolamine
282.  Stearoyl EO
283.  Urea
284.  Dimethylsulfoxide
285.  Butoxy polypropylene g'lycol
286.  Fatty acyl sorbitan EO
287.  Hexafluoropropylmethyl ether
                                      324

-------
TABLE XIV - RANKING OF REPORTED THRESHOLD DOSES OBTAINED BY CHRONIC
                        ADMINISTRATION IN RATS
     This table presents ranking of reported threshold doses which
     happen to have been obtained in rats as reported in the Rus-
     sian literature.   The small size of this table indicates that
     little has been published on chronic threshold doses of com-
     pounds which may appear in fresh water.   There is a notable
     absence of pesticides except for carbathion and simazine which
     have a low ranking.   Most of the other compounds in the table
     are common organics which share little in terms of structural
     similarity.   A noteworthy feature is the presence of the three
     organometallic compounds:   tetraethyltin,  ethyl mercuric
     chloride and diethyl mercury at the top  of the listing.   The
     next  compound listed has a 50-fold  higher  threshold dose in
     the listing  of toxicity of these compounds.   Alcohols,  diols
     and chlorinated compounds  are scattered  throughout  the list,
     as  are aliphatic  and aromatic amines.  Threshold dose  from
     chronic toxicity  studies  is  an important means  for  arriving
     at  quality criteria  for  chemicals in fresh water, the  apparent
     incompleteness  of this table  indicates that efforts have not
     been particularly directed  towards obtaining this information.

-------
TABLE XIV - RANKING OF REPORTED THRESHOLD DOSES OBTAINED  BY  CHRONIC
                    ADMINISTRATION IN RATS
Tetraethyl tin
Ethylmercuric chloride
Diethyl  mercury
DimethyIphenylcarbinol
Heptyl  alcohol
Nonyl alcohol
Cyclohexane
Epichlorhydrin
Tetrachlorobenzene
Dimethylamine
Diisopropylamine
Monoethanolamine
2,4-Dinitrophenol
Hexachlorobutadiene
Freon  253
Ursol
Chloronitrosocyclohexane
Methylamine
Furan
Saponin
Carbon tetrachloride
Perfluorobutenyl ethyl ether
1,4-Butynediol
Cyclohexanol
3-Naphthol
2,5-Dichloraniline
3,4-Dichloraniline
1,2-Dichlorohexafluorocyclopentene-1
Methoxypolypropylene
m-Chloroaniline
Isoprene
Diethylene glycol
Ethylene glycol
Carbathion
mg/kg
0.00001
0.00005
0.00005
0.0025
0.0025
0.005
0.005
0.005
0.005
0.007
0.025
0.025
0.031
0.04
0.05
0.05
0.1
0.1
0.1
0.1
0.15
0.15
0.2
0.2
0.2
0.2
0.2
0.25
0.25
0.25
0.25
0.5
0.5
0.5
mg/1
0.0002
0.001
0.001
0.05
0.05
0.1
0.1
0.1
0.1
0.14
0.5
0.5
0.6
0.8
1.0
1.0
2.0
2.0
2.0
2.0
3.0
3.0
4.0
4.0
4.0
4.0
4.0
5.0
5.0
5.0
5.0
10.0
10.0
10.0
                           325

-------
 TABLE XIV (CONT.) - RANKING OF THRESHOLD DOSES

                                        mg/kg          mg/1
Pinene,  polychloro                    1.0           20.0
Dimethyldithiocarbamate                1.0           20.0
1,4-Butanediol                         3.0           60.0
Isopropylamine                         6.0          120.0
Vetluzhsk Oil                         10.0          200.0
Simazine                              20.0          400.0
2-Hydroxysimazine                     50.0         1000.0
Dimethylformamide                     50.0         1000.0
                          326

-------
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217.   Kuper, A.I.  and V.F. Ozerova.  Experimental basis for the permissible
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234.  Loshakov, Yu.T.  Permissible concentration for butyl xanthate and cresyl
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276.  Nagornyi, S.V.  The maximal permissible concentration of  sodium methyl-
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376.  Smirnova, R.D.  Experimental determination of permissible concentration of
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 56.   Kanygina,  A.  V.  and I.  L.  Rodziller.   Effect of chemical industry waste
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 57.   Kay, K.  Effect  of organic pesticides on enzyme systems in mammals.
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 58.   Keane, W.  T.  and M. R.  Zavon.  The total body burden of dieldrin.  Bull.
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 59.   Kimbrough, R., T. B.  Gaines,  and J. D.  Sherman.  Nutritional factors,
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 60.   Konar, S.  K.   Toxicity  of  heptachlor  to aquatic life.  J.  Water Pollu-
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                                     368

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                                     INDEX
Abate, 206, 292, 301, 322
ABS, 91, 142, 268, 297, 309, 317, 318
Acetaldehyde, 224, 279, 311
Acetamide, 196, 299
Acetic acid, 85, 139, 267, 295, 296,
  308, 318
Acetone, 225, 282, 298, 300, 311
Acetone cyanohydrin, 174, 308, 319
Acetonitrile, 174, 298
3-(a-Acetonylbenzyl)-4-hydroxycoumarin
  (see Warfarin)
Acetophenone, 282, 312
Acetophos, 206, 311, 319
ACP-M-569 (see Amitrole)
Acridine, 176, 281, 299
Acrolein, 225, 282, 301, 312, 319
Acrylic acid, 179, 308, 320
Acrylonitrile, 174, 301, 308, 320
Actusol, 246, 298
Adipic acid, 179
Adiponitrile, 175, 298, 300, 308, 319
Aldrin, 49, 126, 264, 295, 297, 303,
  317
Algibiol, 248, 301
Alkylaryl sulfonate, 186
Alkylbenzene sulfonate (see ABS)
Alkylbenzene sulfonate, linear, 93,
  297, 318
Alkyldimethyl benzylanmonium chloride,
  172, 273, 300, 301, 302, 307, 322
Alkyldimethyl chlorobenzylammonium
  chloride, 172, 300, 301, 302, 323
Alkyl sulfate, 184, 323
Alkyl sulfonate, 186
Allyl alcohol, 162, 305, 320
Allyl chloride, 153, 303
Alodan
2-Aminoethanol salt of 2',5-dichloro 4'-
  nitrosalicylanilide (see Bayluscide)
2-Amino-5-naphthol-7-sulfonic acid
o-Aminophenol, 313
p-Aminophenol, 232, 313
4-Amino-m-toluene-sulfonic acid, 186,
  300
Aminotriazole (see Amitrole)
4-Amino-3,5,6-trichloropicolinic acid
  (see Picloram)
Amitrole, 176, 274, 301, 322
Amyl acetate, 190
Amyl alcohol, 162, 273, 298
Amylene, 152, 299
Aniline, 84, 137, 265, 295, 296, 307, 317
Anisole, 227, 301, 312, 322
Anthraquinone oc-sulfonate, Na, 187
Apholate, 167, 301, 320
Aramite, 190, 275, 301, 323
ATA (see Amitrole)
Atrazine, 176, 274, 288, 301, 323
Azinphosmethyl (see Guthion)
Apholate, 167
Tris(l-Aziridinyl) phosphine oxide  (see
  Tepa)
Azodrin, 206, 301, 319
B
Baron (see Erbon)
Bayer 73 (see Bayluscide)
Bayer 17147 (see Guthion)
Bayer 25141 (see Dasanit)
Bayer 37289 (see Trichloronate)
Baygon, 199, 301, 320
Bayluscide, 196, 301
Baytex (see Fenthion)
1,2-Benzanthracene, 95, 268, 297
Benzene, 232, 282, 299, 313, 324
Benzene Hexachloride, 51, 126, 249, 264,
  297, 317
Benzethonium chloride, 172, 301
Benzidine, 84, 265, 295
S,S'-Benzylidene bis-(o,o-dimethyl phos-
  phoro-dithioate)  (see SD-7438)
3,4- and 10,11-Benzofluoranthene, 96,
  297
11,12-Benzofluoranthene, 96, 297
Benzoic acid, 179, 282, 299, 308
Benzonitrile, 175, 298
1,12-Benzoperylene, 96, 268, 297
3,4,-Benzopyrene, 97, 268, 286, 295, 296,
  297
 Benzoquinone dioxime, 232, 313
Benzo [b] thien-4-yl methylcarbamate (see
  Mobam)
BHC, 51, 126, 249, 264
y-BHC (see Lindane)
                                       369

-------
Bidrin, 207, 292, 301, 319
Binapacryl, 190, 301, 320
Blast, 247. 302
0-(4-Bromo-2,5-dichlorophenyl)0,0-
  dimethyl phosphorothioate (see
  Bromophos)
Bromophos, 207, 301, 322
1,4-Butanediol, 162, 299, 306, 322,
  326
 Butane,  polychloro, 154, 301, 303,
  322
a-[2-(2-Butoxyethoxy)ethoxy]-4,5-
  (methylenedioxy)-2-propyltuluene
  (see Plperonyl)
Butoxy polypropylene glycol, 245, 301,
  315, 324
Butyl acetate, 190, 299, 300, 309, 323
Butyl alcohol, 162, 272, 298, 305, 323
Butyl biphenyl sulfonate, 187, 302, 323
4-tert-Butyl-2-chlorophenyl methyl
  methylphosphoromidate  (see Ruelene)
2-sec-Butyl—4,6-dinitrophenyl isopropyl
  carbonate (see Dinobuton)
2-sec-Butyl-4,6-dinitrophenyl 3-methyl-
  2-butenoate (see Binapacryl)
Butylene, 152, 299, 303
Butyl ether
Butyl mercaptan, 242, 298
Butyl mesityl oxide oxalate, 191, 301,
  324
 2-(p-tert Butylphenoxy)cyclohexyl 2-
  propynyl sulfite (see Omite)
2-(p-tert-Butylphenoxy)-isopropyl 2-
  chloroethylsulfite (see Aramite)
Butyl phenylphenol sulfonate, 187, 323
Butyl sulfonate, Na, 187
Butyl xanthogenate, 243, 299, 300, 315,
  321
1,4-Butynediol, 163, 300, 306, 320, 325
Butyraldehyde, 225
Butyric acid, 86, 139, 179, 267, 295,
  296, 308, 318
                            274
C56, 248, 301
Caproic acid, 86, 139, 179,
Caprolactam, 196, 276, 310
Captan, 197, 276, 289, 301, 323
Carbaryl, 199, 276, 290, 301, 310, 320
Carbathion, 202, 301, 310, 320, 325
Carbon disulfide, 243, 315, 320
Carbon tetrachloride, 154, 272, 298, 299
  303, 324, 325
Carbophenothion, 207, 293, 301, 319
Catechol, 233, 283
Cetyldimethylethylammoniumbromide, 172,
  274, 300, 301, 302, 320
Cheremkhovsk tar intermediate fraction,
  233, 313, 322
Chevron NI-0, 247, 298
Chloramine
Chlordane, 53, 128, 249, 264, 295, 297,
  303, 317
Chlorea (see Monuron)
Chlorenanthic acid, 179, 299, 323
Chlorfenvinfos, 207, 319
Chloroaniline, 237, 298, 301, 314, 320,
  321, 325
Chlorobenzene, 314
p-Chlorobenzene sulfonate, Na, 187, 309
Chlorobenzilate, 191, 301, 322
2-Chloro-l,3-butadiene (see Chloroprene)
Chlorocyclohexane, 155, 303
2-Chloro-l-(2,4-dichlorophenyl) vinyl
  diethyl phosphate (see Chlorfenvinfos)
2-Chloro-2-diethylcarbamoyl-l-methyl vinyl
  dimethyl phosphate (see Phosphamidon)
2-Chloro-4-6-bis-ethylaminotriazine
  (see Simazine)
2-Chloro-4-ethylamino 6-isopropylamine
  S-triazine (see Atrazine)
Chloroform, 155, 272, 288, 298, 323
Chloro IPC (see Chlorpropham)
0-(2-Chloro-4-nitrophenyl)0,0-dimethyl
  phosphorothioate (see Dicapthon)
0-(3-Chloro-4-nitrophenyl)0,0-dimethyl
  phosphorothioate (see Chlorthion)
Chloronitrocyclohexane, 161, 298, 305, 325
5-Chloro-6-oxo-2-norboranecarbonitrlle 0-
  (methylcarbamoyl) oxime (see Tranid)
Chloropelargonic acid, 180, 299, 323
Chlorophenol, 233, 298
bis(p-Chlorophenoxy)methane (see Neotran)
bis(Chlorophenyl) acetic acid (see DBA)
Chlorophenyl chlorobenzene sulfonate, 309
3-(p-Chlorophenyl)-l,l-dimethylurea (see
  Monuron)
1,1-bis(p-Chlorophenyl)-2-nitropropane and
  butane mixture (see Dilan)
                                       370

-------
 S-([(p-Chlorophenyl)thio]methyl}0,0-
   dimethyl phosphorodithioate (see
   Methyl trithion)
 S-{[(p-Chlorophenyl)thio]methyl}0,0-
   diethyl phosphorodithioate (see
   Trithion)
 1,1-bis(p-Chlorophenyl)2,2,2-
   trichloroethanol (see Dicofol)
 Chlorophos, 311
 Chloroprene s 303
 Chloropropham,  200, 277, 291, 301, 310,
   322
 2-Chlorotoluene-4-sulfonate, Na, 187
 2-Chlorotoluene-5-sulfonate, Na, 187
 2-Chloro-l-(2,4,5-trichlorophenyl)
   vinyl dimethyl phosphate (see
   Gardona)
 Chloroundecanoic acid,  180,  299, 324
 Choline chloride, 172
 Chlorthion, 208, 301, 321
 Chrysene,  99,  269
 Ciodrin,  208,  301, 320
 Citric acid,  180, 300
 CMU (see  Monuron)
 Co-Ral (see Coumaphos)
 Corexit 7664,  247, 298
 Coumaphos,  208,  301,  319
 Crag  fly  repellent (see Butoxy  poly-
   propheneglycol)
 Crag  herbicide  (see DCU)
 Crag  herbicide  1 (see Sesone)
 Carg  mylone (see Dazomet)
 Cresol, 100,  145, 271,  295,  318
 Cresyl dithiophosphate,  209,  299,  300,
   311
 Cresylic acid  (see Cresol)
 Cyanuric acid,  176, 308
 Cyclohexane, 152,  298,  303,  323, 325
 Cyclohexanol, 163,  298,  306, 322,  325
 Cyclohexanone, 225, 282, 298, 312
 Cyclohexanone oxime,  225
 Cyclohexene, 152,  298, 302
 Cygon  (see Dimethoate)
D
2,4-D, 86, 140, 267, 285, 297, 308, 317
Dalapon, 180, 301, 308, 323
Dasanit, 209, 301, 319
Dazomet, 203, 301, 321
 2,4-DB, 181, 301, 308
 DBCP, 155
 DBD  (see Guthion)
 DCU, 205, 301, 323
 DDA, 181, 321
 DDD, 103, 147, 255, 269, 286, 295, 297,
   317
 DDE, 109, 148, 256, 295, 297, 318
 DDT, 114, 148, 257, 269, 286, 295, 297,
   314, 317
 DDVP (see Dichlorvos)
 Decachlorooctahydro-1,3,4-metheno-2H-
   cyclobuta(CD)pentalen-2-one)  (see
   Kepone)
 Decylbenzene sulfonate, Na, 187, 275,
   302, 323
 Deet (see Diethyltoluamide)
 Def, 95,  144, 295, 317
 Delnav (see Dioxathion)
 Delrad,  181,  301, 322
 Demeton,  209, 292, 301, 311, 319
 2,4TDep,  191, 301, 319
 Dessin (see Dinobuton)
 bis(Dialkoxyphosphinothioyl)disulfides
   (see Phostex)
 S-[(4,6-Diamino-s-triazin-2-yl)methyl]
   0,0-dimethyl phosphorodithioate (see
   Menazon)
 Diazinon,  210,  292,  301,  320
 Diazobutylamine,  167,  306
 1,2,5,6-Dibenzanthracene,  99,  269,  286
 Dibrom (see Naled)
 l,2-Dibromo-2,2-dlchloroethyl  dimethyl
   phosphate (see  Naled)
 Dibromo-heptafluoroisobutyl methyl  ether,
   227, 298, 322
 Dibutylamine, 167, 321
 Dibutyl phthalate, 191, 275, 279, 312,
   322
 Dicapthon,  210, 293, 301, 320
 Dichlobenil (see  2,6-Dichlorobenzonitrile)
 Dichlone, 233, 301, 322
 2,5-Dichloroaniline, 307, 323
 3,4-Dichloroaniline, 171, 238, 307, 321,
   325
 p-Dichlorobenzene, 238, 280, 301, 321
 2,5-Dichlorobenzene sulfonate, Na, 188
 2,6-Dichlorobenzonitrile, 85, 138, 297,
  317
 Dichlorobutane,  156, 299,  304
Dichlorobutene, 304
                                       371

-------
1,l-Dichloro-2,2-bis(p-chlorophenyl)
  ethane (see DDD)
1,l-Dichloro-2-bis(p-chlorophenyl)
  ethylene (see DDE)
Dichlorocyclohexane, 156, 304, 321
Dichloroethane, 156, 322
1,l-Dichloro-2,2-bis(p-ethylphenyl)
  ethane (see Perthane)
1,2-Dichlorohexafluoro-1-cyclohexene,
  157, 304
1,2-Dichlorohexafluorocyclopentene-1,
  157, 299, 304, 320, 325
Dichlorohydrin, 163, 306, 320
Dichloromethane, 157, 281, 299, 304, 324
Dichloronaphthoquinone  (see Dichlone)
Dichlorophenol, 313
2,4-Dichlorophenoxyacetic acid (see
  2,4-D)
3-(3,4-Dichlorophenyl)-1,1-dimethyl
  urea (see Diuron)
2,2-Dichloropropionic acid (see
  Dalapon)
2,2-Dichlorovinyl dimethyl phosphate
  (see Dichlorvos)
Dichlorvos, 211, 293, 301, 319
Dicofol, 238, 301
Dicyanodiamide, 197, 310
Dieldrin, 54, 129, 250, 264, 284, 295,
  297, 304
Diethanolamine, 167, 306, 322
Diethylamine, 84, 135, 281, 295, 307,
  317, 321
0,0-Diethyl 0- (3-'chloro-4-methyl-2-
  oxo-2H-l-benzopyran-7-yl) phosphoro-
  thioate (see Coumaphos)
Diethylchlorthiophos, 311
Diethyl dithiocarbamate, Na, 203
Diethyl dithiophosphoric acid, 211,
  301, 311, 322
Diethylene glycol, 163, 273, 299, 300,
  306, 325
Diethyl ether, 227, 312
0,0-Diethyl S-[2-(ethylthio)ethyl]
  phosphorodithioate (see Disulfoton)
0,0-Diethyl S-[(ethylthio) methyl] phos-
  phorodithioate (see Phorate)
0,0-Diethyl 0-(2-isopropyl-4-methyl-
  6-pyrimidinyl) phosphorothioate (see
  Diazinon)
Diethyl maleate, 191, 301, 309, 322
Diethyl mercury, 244, 298, 315, 320,
  324
0,0-Diethyl-0-[p(methylsufinyl)phenyl]
  phosphorothioate (see Dasanit)
0,0-Diethyl-O-p-nitrophenyl phosphoro-
  thionate (see Parathion)
0,0-Diethyl-O-p-nitrophenyl phosphate
  (see Paraoxon)
0,0-Diethyl-0-2-pyrazinyl phosphorothioate
  (see Thionazin)
Diethyl toluamide, 197, 301, 323
0,0-Diethyl 0-(3,5,6-trichloro-2-pyridyl)
  phosphorothioate (see Dursban)
3,9-Diethyl-tridecyl-6-sulfonate, 184,
  302, 321
6,7-Dihydrodipyrido[1,2a:2'1'c]pyrazinedium
  bromide (see Diquat)
Diisopropylamine, 168, 298, 307, 321, 325
Diisopropyl dithiophosphate, K, 211, 299,
  311
3,5-Diisopropylphenyl N-methylcarbamate
  (see HRS-1422)
Dilan, 239, 301, 321
Dimethoate, 211, 311, 319
2,2-Di-(p-methoxypheny1)-1,1,1-trichlor-
  ethane (see Methoxychlor)
Dimethrin, 192, 301, 323
Dimethylamine, 84, 135, 295, 307, 317,
  320, 325
4-(Dimethylamino)-m-tolyl methylcarbamate
  (see Matacil)
4-(Dimethylamino)-3,5-xylyl methyl-
  carbamate (see Zectran)
Dimethylaniline
0,0-Dimethyl S[4-oxo-l,2,3-benzotriazin-
  3(4H)-ylmethyl]phosphorodithioate (see
  Guthion)
Dimethyl carbate, 192, 301, 322
0,0-Dimethyl-S-(1,2-dicarbethoxyethyl)
  phosphorodithionate (see Malathion)
DimethyIdioxane, 227, 321
1,1'-Dimethyl-4,4'-dipyridinium di-
  (methyl sulfate) (see Paraquat)
Dimethyldithiocarbamate, NH^, 203, 310,
  321, 326
Dimethyldithiophosphoric acid, 212, 311
0,0-Dimethyl-3-ethyImercaptoethyl
  dithiophos (see Methyl demeton)
Dimethylformamide, 197, 298, 310, 326
Dimethyllaurylbenzylammonium bromide
  (see Sterinol)
0,0-Dimethyl S-(N-methylcarbamoyl methyl)
  phosphorodithioate (see Dimethoate)
                                       372

-------
0,0-Dimethyl 0-[4-(methylthio)-m-
  tolyl] phosphorothioate (see Fenthion)
0,0-Dimethyl 0-p-nitrophenyl phos-
  phorothioate (see Methyl parathion)
D ime thyIpheno1
Dimethylphenylcarbinol, 164, 298, 306,
  323, 325
Dimethylphthalate, 192
0,0-Dimethyl S-phthalimidomethyl
  phosphorodithioate (see Imidan)
Dimethyl resorcinols, 234, 299, 313, 322
Dimethyl sulfide, 243, 298, 315, 323
Dimethylsulfoxide, 243, 324
Dimethylterephthalate, 192, 309
bis(Dimethyl thiocarbamoyl) ethylene
  bis(dithiocarbamate) (see Triaram)
bis(Dimethylthiocarbamoyl) disulfide
  (see Thiram)
Dimethyl (2,2,2-trichloro-1-hydroxy-
  ethyl) phosphate (see Trichlorfon)
0,0-Dimethyl 0-2,4,5-trichlorophenyl
  phosphorothioate (see Ronnell)
Dimetilan, 200, 301, 319
p-Dinitrobenzene, 241, 319
Dinitrocresol, 234, 301, 319
2,4-Dinitrophenol, 279, 301, 313, 319,
  325
Dinitrotoluene, 241, 300
Dinitrotoluol (see Dinitrotoluene)
Dlnobuton, 192, 301
Dinoseb, 201, 320
Dinoterb acetate
Dioctylphthalate, 309
Dioctyl succinate sulfonate, 188, 323
Dioxane, 279
S, S'-p-Dioxane-2,3-diyl-O,0-diethyl
  phosphorodithioate (see Dioxathion)
Dioxathion, 212, 301, 319
Diphacinone, 225, 301, 319
2-(Diphenylacetyl)-1,3-indandione
  (see Diphacinone)
Diphenylolpropane, 234, 313
Dipterex (see Trichlorfon)
Diquat, 173, 301, 321
Disodium ethylene bis-dithiocarbamate
  (see Nabam)
Disulfoton, 212, 301, 319
Disyston (see Disulfoton)
Diuron, 205, 278, 292, 301, 323
DNBP (see Dinoseb)
DNOC (see Dinitrocresol)
Dodecachlorooctahydro-1,3,4-metheno-2H-
  cyclobuta (cd) pentalene (see Mirex)
Dodecylbenzene sulfonate, 188, 275, 302,
  323
Dodecyldiphenyl ether sulfonate, 188, 322
Dowpon (see Dalapon)
Drione, 193, 301
Dursban, 213, 320
Dylox (see Trichlorfon)
E-314, 247, 298
EDB (see Ethylene dibromide)
Endosulfan, 66, 130, 265, 297, 317
Endothall, 182, 288, 301, 319
Endrin, 66, 130, 253, 284, 295, 297, 304,
  417
Entex (see Fenthion)
Epichlorhydrin, 228, 298, 320, 325
EPN, 293, 301, 319
Erbon, 239
Ethion, 213, 301, 319
Ethyl acetate, 193, 275, 323
Ethyl alcohol, 164, 273, 300
Ethylamine, 84, 136, 271, 295, 307, 317,
  321
Ethylbenzene, 242, 315
2-Ethylbutylamine, 168
Ethyl 4,4'-dichlorobenzilate (see Chloro-
  benzilate)
Ethylene, 152, 298, 299, 300, 302
Ethylenediamine, 168, 322
Ethylene dibromide, 158, 281, 288, 320
Ethylene dichloride, 158, 321
Ethylene glycol, 164, 273, 306, 324, 325
Ethylene glycol monobutyl ether, 273
Ethylene glycol monoethyl ether, 273, 306
Ethylhexanediol, 164, 281, 301, 323
2-Ethylhexyl sulfate, 184, 322
Ethylmercuric chloride, 245, 294, 315,
  320, 325
7-Ethyl-2-methyl-undecyl-4-sulfate, 184,
  302, 321
0-Ethyl-O-p-nitrophenyl phenylphosphoro-
  thioate (see EPN)
Ethyl phenylphenol sulfonate, 189, 302,
  323
S[(2-Ethylsulfinyl)ethyl]0,0-dimethyl
  phosphorothioate (see Oxydemetonmethyl)
                                       373

-------
0-Ethyl 0-2,4,5-trichlorophenyl
  ethyl phosphorothioate  (see
  Trlchloronate)
F-98 (see Acrolein)
Fatty acyl sorbitan EO-20, 228, 302,
  324
 Fenac,  88, 140, 297, 318
Fenitrothion (see Sumlthion)
Fenthion, 214, 301, 320
Fenuron, 205, 301, 324
Ferbam, 203, 277, 391, 301, 323
Fermate (see Ferbam)
Fluoranthene, 99, 271, 297
FO-300B, 247, 298
Folex, 214, 301, 322
Formaldehyde, 226, 282, 294, 299, 300,
  312, 322
Formate (see Formic acid)
Formic acid, 88, 140, 295, 296, 309, 318
Freon 253, 158, 304, 320, 325
Fulvic acid, 88
Furan, 228, 300, 312, 325
Furfural, 226, 298, 299, 301, 312, 320
Gamlen-CW, 247
Gardona, 214, 301, 322
Glucose, 83, 265
Glutaric acid, 182
Guaiacol, 235, 283, 299
Guthion, 214, 293, 301, 319
H
HCB (see Hexachlorane)
HCE (see Heptachlor epoxide)
Hempa, 197, 301, 323
Heptachlor, 72, 132, 254, 265, 295,
  297, 304, 317
Heptachlor epoxide, 76, 253, 265, 297,
  304
Heptachloronorbornene, 80, 295
l,4,5,6,7,8,8a-Heptachloro-3a,4,7a-
  tetrahydro-4,7-methanoindene (see
  Heptachlor)
Heptafluoroisobutylene methyl ether,
  228, 322
Heptane, 153, 298
Heptyl alcohol, 164, 306, 325
Hercules 528 (see Dioxathion)
Hercules 9699, 215, 301, 320
Hexachlorane, 124
Hexachlorobenzene, 239, 314
Hexachlorobutadiene, 158, 301, 304, 320,
  325
Hexachlorobutane
1,2,3,4,5,6-Hexachlorocyclohexane  (see
  Lindane)
Hexachlorocyclopentadiene, 158, 299, 304,
  321
Hexachloroethane, 159, 299, 301, 304, 323
l,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-
  hexahydro-1,4,5,8-endo-endo dimethanona-
  phthalene  (see Isodrin)
l,2,3,4,10,10-Hexachloro-l,4,4a,5,8,8a-
  hexahydro-1,4-endo-exo-5,8-dimethano-
  naphthalene (see Aldrin)
6,7,8,9,10,10-Hexachloro-l,5,5a,6,9,9a-
  hexahydro-6-9wmethano-2,3,4-benzo-
  dioxathiepin-3-oxide (see Endosulfan)
Hexachloronorbornadiene, 80, 295
l,2,3,4,10,10-Hexachloro-6,7-epoxy-l,4,
  4a,5,6,7,8,8a-oxtahydro-l,4-endo-endo~
  5,8-dimethanonaphthalene (see Endrin)
1,2,3,4,10,10-Hexachloro-6,7-epoxy,1,4,
  4a,5,6,7,8,8a-octahydro-1,4-endo-exo-
  5,8-dimethanonaphthalene (see Dieldrin)
Hexafluoropropyl methyl ether, 229, 324
Hexamethylenediamine, 168, 300, 307
Hexamethylenediamine adipate, 168, 273,
  300, 307
Hexamethylphosphoric triamide (see Hempa)
Hexyl alcohol, 165
Hexylamine,  169
Holl-Chem 622, 247, 298
HRS-1422, 215, 320
Hyamine 1622 (see Benzethorium chloride)
Hydrazine hydrate, 307
Hydroquinone, 235, 300, 313, 321
3-Hydroxy-N,N-dimethylcrotonamide dimethyl
  phosphate  (see Bidrin)
3-Hydroxy-N-methyl-cis-crotonamide dimethyl
  phosphate  (see Azodrin)
2-Hydroxysimazine, 177, 326
                                       374

-------
Imidan, 215, 293, 301, 320
Indalone (see Butyl mesityl oxide
  oxalate)
Indeno[l,2,3-cd]pyrene, 99, 297
IPC, 200, 277, 291, 301, 310, 322
Isobutyl alcohol, 165, 300, 306
Isobutylene, 153, 299, 303
Isobutyric acid, 88
Isodrin, 80, 132, 295, 297, 317
Isolan, 200, 277, 301, 319
Isoprene, 153, 299, 303, 325
Isopropylamine, 169, 301, 307, 321, 326
Isopropyl-N-(3-chlorophenyl) carbamate
  (see Ch.loropropb.am)
Isopropyl-N-phenyl carbamate (see IPC)
0-Isopropoxyphenyl-N-methyl carbamate
  (see Baygon)
l-Isopropyl-3~methylpyrazol<~5^yl di~
  methylcarbamate (see Isolan)
Isopropylmethyl phosphoryl fluoride
  (see Sarin)
Isopropylnaphthalene sulfonate, Na, 189,
  275, 302, 323
Isoquinoline, 177
Isovaleric acid, 89
Jan-Solv-60, 247, 298
K
Karbofos  (see Malathion)
Kelthane  (see Dicotol)
Kepone, 159, 301, 320
Kuron  (see Silvex)
Lactic acid, 182, 274, 300, 309
Lactonitrile, 175, 298
LAS  (see Alkyl benzene sulfonate,
  linear)
Laurie diethanolamide sulfonate, 185,
  302, 323
Lauryl alcohol EO, 229, 302
Lauryl alcohol sulfate EO, 185, 302, 322
Lauryl glyceryl ether sulfonate, 302, 323
Lauryl glyceryl sulfate, 185
Lauryl imidazoline, 173, 302, 323
Lauryl sulfate, 185, 302, 322
Lethane 384, 175, 301, 320
Lindane, 81, 128, 133, 255, 265, 284, 297
  304, 317
M
Malaoxon, 216, 319
Malathion, 216, 278, 293, 301, 311, 319
Maleic acid, 182, 298, 309
Maleic anhydride, 182, 309
Malonic acid, 182
Matacil, 200, 301, 319
MCPB, 182, 301, 321
Menazon, 218, 301, 322
e-Mercaptodiethylamine, 169, 301, 307
Mercaptophos (see Demeton)
Merphos (see Folex)
Mesurol, 201, 301, 320
Metaphos (see Methyl parathion)
Metepa, 198,  89,  01, 320
Methacrylamide, 198, 310, 321
Metham, 203, 301, 320
Methane, 49, 126, 295, 296
Methomyl, 201
Methoxychlor, 239, 280, 301, 314, 323
Methoxy polypropylene glycol, 246, 300,
   315, 325
Methylacetophos, 218, 311,  319
Methyl alcohol, 165, 298, 306
Methylamine, 84, 136, 295,  307, 319, 325
Tris(2-Methyl-l-aziridinyl) phosphine
  oxide (see Metepa)
Methyl benzoate, 193, 309,  323
a-Methylbenzyl 3-hydroxycrotonate dimethyl
  phosphate  (see Ciodrin)
Methyl-demeton, 218, 293, 311, 320
Methyldithiocarbamate, Na (see
  Carbathion)
Methylethylketone, 226, 279, 298, 312, 323
Methyl hexafluoro-2-bromobutyrate, 193,
  298, 322
Methyl hexafluoroisobutyrate, 193, 321
Methyl 3-hydroxy-a-crotonate dimethyl
  phosphate  (see Mevinphos)
Methyl mercapton, 243, 300
                                        375

-------
S-Methyl-N-(methylcarbamoyloxy)thio-
  acetamidate, 301
(2-Methyl-2-methylthio)propionaldehyde
  0-(methylcarbamoyl)oxime (see
  Temik)
Methylmercurlc chloride, 125, 151, 287,
  296, 297, 317
Methylolmethacrylamide, 198, 321
Methylparathlon, 219, 293, 301, 311, 319
Methyl perfluoromethacrylate, 193, 320
6-Methyl-2,3-quinoxalinedithiol cyclic
  S,S'-dithiocarbonate  (see Morestan)
Methylsiliconate, Na, 246, 316, 323
Methylstyrene, 242, 315, 323
Methyl systox  (see Methyl-demeton)
Methyl tetrafluoropropionate, 194, 298,
  323
4-(Methylthio)-3,5-xylyl methylcarbamate
  (see Mesurol)
2-(Methylthio)~4,6-bis(isopropylamino)-
  S-triazine (see Prometryne)
Methyl trithion, 219, 301
Methyl zimate  (see Ziram)
Mevinphos, 219, 301, 319
MGK Repellent 11, 226, 301, 323
MGK 264, 198, 398, 323
MGK Repellent 326, 194, 302, 324
Mirex, 159, 272, 302, 321
Mobam, 201, 302, 320
Monochlorohydrin, 165, 306, 320
Monoethanolamine, 169, 298, 300, 302,
  322, 324
Monuron, 205, 278, 292, 302, 323
Morestan,  177, 322
Morpholine, 177, 300, 322
Mustard gas, 244, 283, 319
N
Nabam, 204, 277, 291, 302
Naled, 220, 301, 320
Naphthalene, 232, 279, 299, 313, 323
Naphthol, 235, 279, 283, 294, 299,
  302, 313, 320, 325
1,4-Naphthoquinone, 236, 313
Naphthylamine, 85, 266, 295
1-Naphthyl N-methylcarbamate  (see
  Carbaryl)
Nemagon (see DBCP)
Neotran, 229, 302, 324
Nicotine, 177, 281, 302, 319
Nitroaniline, 171, 321, 322
Nitrobenzene, 241, 298, 314, 322
mrvNitrobenzene sulfonate, Na, 189
Nitrochlorobenzene, 125, 150, 314, 317
4<-Nitrochlorobenzene-2-sulfonate, Na

Nitrocyclohexane, 161, 305
Nitromethane, 162, 305, 322
Nitroethane, 161, 322
Nitrophenol, 236, 321
4-Nitrotoluene-2-sulfonate, Na, 189
Nitrotoluol, 236, 313
Nonyl alcohol, 165, 306, 325
Nonyl phenol EO, 229, 302, 322
Norsulfazole, (see Sulfathiazole)
l,2,4,5,6,7,8,8-0ctochloro-2,3,3a,4,7,
  7a-hexahydro-4,7-metanoindene  (see
  Chlordane)
Octafluoroisobutyl methyl ether, 229,
  298, 322
Octamethylpyrophosphoramide  (see Schradan)
Octylphenol EO, 229, 323
Oleoylmethyl tauride, 190, 299, 323
Oleyl alcohol EO, 165, 302,  323
Omite, 194, 320
OMPA  (see Schradan)
OP-7  (see Polyethyleneglycolakylphenyl
  ether)
OP-10 (see Polyethyleneglycolakylphenyl
  ether)
OPS-B (see Butoxy polypropheneglycol)
OPS-M (see Methoxy polypropylene glycol)
Orthocide  (see Captan)
Ovex, 194, 276, 288, 302, 323
Ovotran  (see Ovex)
Oxalic acid, 183
Oxydemetonmethyl,  220, 302, 319
Oxydipropionitrile, 175, 298
Paraoxon, 220, 302, 319
Paraquat, 173, 302, 320
Parathion, 221, 293, 311,  319
Pentachlorophenolate, Na,  146,  269,  317
                                        376

-------
Pentachlorophenol, 110, 146, 269, 286,
  317
4-(p-tolyl)-l-Pentanol, 167, 300
Perf]uoroisobutenyl ethyl ether, 230,
  299, 312, 320, 325
Perthane, 240, 280, 302, 323
Petrollte W-1439, 247, 298
Phenanthrene, 232, 283, 313, 322
Phenol, 101, 146, 295, 296, 297,
  313
Phenols (shale)  (see Dimethyl
  resorcinols)
Phenylamine  (see Aniline)
3-Phenyl-l,l-dimethylurea (see Fenuron)
p-Phenylenediamine (see Ursol)
Phenyl ether, 95, 296
Phenylhydrazine, 170, 281, 298, 299, 300,
  302, 306, 320
Phorate, 221, 302, 319
Phosdrin (see Mevinphos)
Phosphamidon, 222, 293, 302, 319
Phostex, 244, 302, 320
Phthalic acid, 183, 282, 309, 322
Phygonyl (see Dichlone)
Picloram, 178
Picoline, 177, 300, 308, 3 9
Pindone (see Pival)
Pinene, polychloro, 159, 302, 305, 326
Pine oil, 165, 299, 306
Piperonyl butoxide, 230, 279, 302, 324
Pival, 226, 302, 320
2-Pivalyl-l,3-indandione (see Pival)
Polycomplex A-ll, 247
Polyethyleneglycolakylphenyl ethers,
  302, 312
Poly(ethylhydrosiloxane), 246, 316
Polymethacrylate, cationic, 246, 316
Polystyrene, cationic, 246, 316, 322
Prolate (see Imidan)
Prometryne, 178, 323
Propham (see IPC)
Propionate, 89, 140
Propionic acid (see Propionate)
Propyl alcohol, 165, 273, 300, 323
Propyl benzene, 315
Propylene,  153, 298, 300, 303
Propyl isotne, 194, 276, 298, 323
2-(2-Propynyloxy)phenyl N-methyl-
  carbamate (see Hercules 9699)
Pyrene, 100, 145, 271, 297, 313, 318
Pyrethrins, 195, 276, 302, 320
Pyridine, 85, 138, 267, 295,  296,  308
Pyrocatechol, 101, 147, 295,  296,  297,
  318
Pyrogallol, 236, 283, 299, 300, 319
Quaternary ammonium chloride, 173, 302,
  307, 322
Quaternary pyridinium, 173, 302, 320
Quinaldine, 178, 299, 322
Quinoline, 178, 299
Quinone, 236, 299, 300, 313, 320
R
Rogor (see Dimethoate)
Ronnell, 94, 144, 297, 318
Rosolic acid, 236, 299
Rotenone, 230, 279, 302, 320
Ruelene, 222, 302, 321
Rutgers 612  (see Ethyl hexanediol)
Saponin, 231, 298, 312, 325
Sarin, 222
Schradan, 222, 302, 319
SD-7438, 223, 302
SD-8530, 201, 302, 320
Seasweep, 247, 298
Sesame oil, 195, 298, 323
Sesone, 186, 302, 321
Sevin (see Carbaryl)
Shell D-50, 248, 302
Silvex, 89, 141, 297, 317
Simazine, 178, 274, 288, 302, 323, 326
Sodium N-methyl dithiocarbamate (see
  Metham)
Soricide tetraminol, 248, 302
Spill-X, 248, 298
Stearoyl EO, 195, 302, 324
Stearyl alcohol EO, 231
Sterinol, 174, 302, 320
Sterox, 302
Streptomycin, 166, 281, 300, 306,  320
Strobane, 159, 272, 302, 320
Strychnine, 179, 302
                                        377

-------
Sulfadimesine, 310
Sulfaguanidine, 276, 310
Sulfanilamide, 198, 276, 310,.324
Sulfathiazole, 198, 310
Sulfoxide, 244, 298, 321
Sumithion, 223, 302, 320
Systox (see Demeton)
2,4,5-T, 90, 141, 267, 285, 309
Tabutrex, 195, 302, 324
Tannic acid, 183, 274
2,3,5-TBA, 183, 302, 321
2,3,6-TBA, 183, 302, 322
TCA, 183
IDE (see DDD)
Tedion, 125, 270, 286
Temik, 201, 302, 319
Tepa, 199, 289, 302, 319
TEPP, 223, 302, 319
Terephthalic acid, 89
Terpene polychlorinates (see Strobane)
Terpineol, 166, 299, 306
Tetrachlorobenzene, 240, 302, 314, 322,
  325
Tetrachlorocatechol, 237, 300
Tetrachloroethane, 159, 272, 299, 302,
  305, 322
Tetrachloroethylene, 160, 272, 298
Tetrachloroheptane, 160, 298, 305, 321
Tetrachlorononane, 160, 298, 305, 322
Tetrachloropentane, 160, 305, 321
Tetrachloropropane, 160, 305, 321
Tetrachloroundecane, 161, 305
Tetraethyl lead, 245, 298, 315
Tetraethyl pyrophosphate  (see TEPP)
O.O.O'.O'-Tetraethyl-S.S'-methylene bis
  phosphorodithioate  (see Ethion)
Tetraethyl tin, 245, 315, 319, 325
Tetradifon  (see Tedion)
Tetrahydrofuran, 231, 312
Tetrahydrofurfuryl alcohol, 166, 300,
  306
0,0,0',0'-Tetramethyl 0,0'-thio di-p-
  phenylene phosphorothioate  (see
  Abate)
Thanite, 176,  322
Thiodan  (see Endosulfan)
Thiometon  (see Methyl-demeton)
Thionazin, 223, 302, 319
Thiophene, 244, 299, 315
Thlophos  (see Parathion)
Thiram, 204, 278, 291, 302
Tiguvon (see Fenthion)
Toluene, 242, 280, 299, 315, 324
Toxaphene, 83, 134, 297, 305, 317
2,4,5-TP  (see Silvex)
Tranid, 202, 302, 319
Triaram, 204, 302
Tributyl phosphate, 223, 311, 322
Tributyl phosphorotrithioite, (see Folex)
S,S,S-Tributyl phosphorotrithioate (see
  Def)
Trichlorfon, 224, 302, 321
Trichloroacetic acid (see TCA)
Trichlorobenzene, 241, 299, 314
Trichlorobenzoic acid  (see 2,3,5-TBA
  and 2,3,6-TBA)
1,1,1-Trichloro-2,2-bis(p-chlorophenyl)
  ethane  (see DDT)
Trichloroethylene, 161, 281, 298, 305,
  324
N~Trichloromethylmercapto-4-cyclo-
  hexene-l,2-dicarboximide  (see Captan)
Trichloronate, 224, 302, 319
2,4,5-Trichlorophenoxyacetic ac id
  (see 2,4,5-T)
2-(2,4,5-Trichlorophenoxy) ethyl 2,2-
  dichloropropionate (see Erbon)
2,3,6-Trichlorophenylacetic acid (see
  Fenac)
Triethanolamine, 170,  299, 307, 324
Triethylamine, 170, 321
Trifluorochloropropane  (see Freon 253)
3,4,5-Trimethylphenyl methyl carbamate
  (see SD-8530)
Trithion  (see Carbophenothion)
Trolene (see Ronnell)
U
Urea, 205, 310, 324
Ursol, 171, 299, 307, 325
VA-102 (see Polymethacrylate, cationic)
VA-2  (see Polystyrene, cationic)
                                       378

-------
VA-3 (see Polystyrene, cationic)
Valeric acid, 89, 141
Vapam (see Metham)
Vetluzhsk oil, 237, 300, 313, 321, 326
Vinyl acetate, 195, 309, 323
X
Xylene, 241, 283, 298, 299, 314, 323
W
Warfarin, 196, 302, 319
Weedazol  (see Amitrole)
Weedex (see 2,4-D)
Zectran, 202, 277, 291, 302, 319
Zinc ethylene bis(dithiocarbamate)  (see
  Zineb)
Zinc dimethyldithiocarbamate (see Ziram)
Zineb, 204, 278, 302, 322
Ziram, 204, 278, 302
                                       379

-------
     Accession Number
  W
                     A I Subject Field & Group
                                           SELECTED  WATER RESOURCES ABSTRACTS
                                                  INPUT TRANSACTION FORM
     Organization
                    Arthur D.  Little, Inc., Cambridge, Massachusetts
                    Life Sciences Division
     Tltlo
         Water Quality Criteria Data Book, Vol. 1 - Organic Chemical Pollution of
            Freshwater
1 0 1 Authot{8)
	 Davis, Thomas R. A.
Burg, Alan W.
Neumeyer, John L.
Butters, Kathleen M.
Wadler, Bella D.
M.D.
PhD.
PhD.
A.B.
M.S.
'O |
18010DPV
2| I JVoto
 22
     Citation
     December,  1970.  379 pp., 16 tab, 577 ref.
 23
Deac'riptora (Starred First)

 *0rganic Compounds, *Fresh Water, *Water  Pollution Sources, *Water Quality,
 *Toxicity, Human Pathology, Animal  Pathology,  Public Health, Water Pollution
 Effects
 25
Identifiers (Starred First)

*Acute Toxicity, *Chronic Toxicity, *Carcinogenicity,  Mutagenicity,
 Teratogenicity, Tissue Concentrations
 27
     Abstract
      Four hundred, ninety six organic chemicals have been reported to "be found or are
      suspected to be in fresh water.  Of these, sixty  six have been identified.   As
      might be expected, evidence which directly relates the  presence of organic
      chemicals in fresh water with human health is generally lacking.
           Industrial sources were responsible for the  largest number and variety of
      structural types of organic chemical pollutants.  Reported  agricultural sources
      of pollutants were all pesticides and domestic sources  were all detergents.
      Animal toxicity consisted mainly of acute toxicity data. Pesticides were shown
      to be the most acutely toxic organic chemicals in water and only  methyl mercuric
      chloride was found to be more toxic.  Although the information on chronic threshold
      doses was insufficient for meaningful interpretation, the organometallics ranked
      high in chronic toxicity effects.
           Of one hundred twenty compounds examined for carcinogenicity in animals, 22.5
      percent were positive.  Of thirty two compounds examined for teratogenicity in
      animals, 62.5 percent were positive.  Although there is no  proven chemical mutagen
      for man, all showed some effects on genetic material.
           Factual information upon which quality criteria of water can be rationally
      based is generally lacking.
Abstractor
	Thomas R. A. Davis, M.D.
                               IftNlitiilion
                                      Arthur D. Little, Inc.
  WR:ID2 (REV. JUI_r 19691
  WRSIC
                        SEND, WITH COPY OF DOCUMENT. VO: WATER RESOURCES SCIENTIFIC INFORMATION CENTER
                                                  U.S. DEPARTMENT OF THE INTERIOR
                                                  WASHINGTON. O. C. 20240
                                                                         O GPO : 1911 O - 442- 9«3  I

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