_..<.€0 ?,*4,.
^ I UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
/ WASHINGTON, D.C. 20460
OFFICE: OF
PESTICIDES AND TOXIC SUBSTANCES
SUBJECT: Transmittal of Copies of Chlorpyrifos Guidance
Document
TO:
Attached for your information is a copy of the Chlor-
pyrifos Guidance Document. Questions regarding this document
may be addressed to Jay S. Ellenberger, Product Manager (12),
at 703/557-2386.
If you no longer wish to receive future copies of regis-
tration standards and/or special review documents, please
contact the following individuals for removal of your name
(or replace your name with that of another) from the mailing
list:
Ferial S. Bishop
U.S. Environmental Protection Agency
Registration Division
401 M Street, S.W.
Washington, D.C. 20460
Sincerely yours,
Jay S^ Ellenberger
Product Manager (12)
Insecticide-Rodenticide Branch
Registration Division (TS-767)
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GUIDANCE FOR THE
REREGISTRATION OF PESTICIDE PRODUCTS
CONTAINING
CHLQRPYRIFOS
AS THE ACTIVE INGREDIENT
059101
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20460
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TABLE OF CONTENTS
Introduction 1
I. Regulatory Position and Rationale 4
Site Pest Table of Contents .... ... ...... 29
II. Requirement for Submission of Generic Data 34
III. Requirement for Submission of Product-Specific
Data 37
IV. Submission of Revised Labeling and Packaging
Information. 38
A. Label Contents 38
1. Product Name 38
2. Company Name and Address 38
3. Net Contents 38
4. Product Registration Number 38
5. Producing Establishment
Registration Number 39
6A Ingredient Statement 39
6B Pounds Per Gallon Statement 39
7. Front Panel Precautionary Statements 39
7A Child Hazard Warning Statements 40
7B Signal Word 40
7C Skull and Crossbones and Word Poison 40
7D Statement of Practical Treatment . 40
7E Referral Statement 40
8. Side/Back Panel Precautionary Labeling ..... 40
8A Hazard to Humans and Domestic Animals 41
8B Environmental Hazard 41
8C Physical or Chemical Hazard 41
9 Misuse Statement 42
10A Storage and Disposal Block..... . . . 42
10B Directions for Use 42
B. Collateral Information 42
V. Instructions for Submission 43
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APPENDICES
II-l Bibliography
11-2 FIFRA §3(c)(2)(B) Summary Sheet - EPA Form 8580-1
II-3 Certification of Attempt to Enter Into an Agreement
With Other Registrants for Development of Data
EPA Form 8580-6
III-l Product Specific Data Report (End-Use Products)
EPA Form 8580-4
IV-1 40 CFR §162.10 Labeling Requirements
IV-2 Table of Labeling Requirements and Sample Labels
IV-3 Physical/Chemical Hazards Labeling Statement
IV-5 Storage and Disposal Statements
Note: Appendices IV-4 and IV-6 are not germane to this
document and are not included.
11
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INTRODUCTION
The Federal Insecticide, Fungicide, and Rodenticide Act
(FIFRA) Section 3(g), as amended in 1978, directs EPA to
reregister all pesticides as expeditiously as possible. Each
registrant of a manufacturing use product of the active
ingredient who wishes to continue to sell or distribute that
product must apply for reregistration.
To fulfill this Congressional mandate, we have established
the Registration Standards program which will review all pesti-
cide active ingredients first registered before January 1,
1977. These pesticides will be reviewed in use clusters
which are prioritized on the basis of a ranking scheme giving
preference to pesticides used on food and feed crops.
The Registration Standards program involves a thorough
review of the scientific data base underlying pesticide
registrations and an identification of essential but missing
studies which may not have been required when the product
was initially registered or studies that are now considered
insufficient. Our reassessment results in the development
of a regulatory position, contained in this document, on
each pesticide and its uses. The regulatory position may
require the registrant to modify product labels to provide
additional precautionary statements, restrict the use of the
pesticide to certified applicators, provide reentry intervals,
modify uses or formulation types, specify certain packaging
limitations, or other requirements to assure that proper use
of the pesticide poses no potential adverse effects to human
health or the environment.
The scientific review, which is not contained herein
but is available upon request, concentrates on the technical
grade of the active ingredient and identifies missing generic
data. However, during the review of these data we are also
looking for potential hazards that may be associated with
the formulated (end-use) products that contain the active
ingredient. If we find serious concerns, we will bring
formulated products under the provisions of the Registration
Standards program to the extent necessary to protect the
public.
EPA has the authority under FIFRA'§3(c)(2)(B) to require
that certain registrants submit generic data that will answer
our questions regarding the hazard that may result from the
intended use of the pesticide under review. Further, §3(c)
(2MB) provides that these data are to be submitted by
those registrants who do not qualify for the formulator's
exemption [FIFRA §3(c)(2)(D)]. Normally, this means that
the registrants who are responsible for filling the data
gaps are the manufacturing-use product producers (basic
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suppliers of the active ingredient). However, end-use producers
will not qualify for the formulator's exemption if the source
of their active ingredient: (1) is not registered with EPA,
and/or (2) is produced by the registrant's firm, or a firm which
has ownership in common with the registrant's firm. These end-use
producers can qualify for the formulator's exemption if they
change their source of supply to a registered source, provided the
source does not share ownership in common with the registrant's
firm. If the end-use product registrant decides to switch sources,
a new Confidential Statement of Formula, EPA Form 8570-4, must be
submitted to the appropriate Product Manager within 90 days of
receipt of this Guidance Document. The chart on the following
page shows what is generally required of those who do and do not
qualify for the formulator's exemption in the Registration
Standards program.
If you decide to request the Agency to discontinue the
registration of any of your products subject to the reregistra-
tion requirements of this Guidance Document, please notify the
Product Manager named in the cover letter, within 90 days from
the receipt of this document, that you wish to voluntarily cancel
the registration(s) . If you decide to maintain your product
registration(s), you must provide the information described in
the following pages within the timeframes outlined. EPA will
issue a notice of intent to cancel or suspend the registration
of any currently registered product if you fail to comply with
the requirements set forth in this Guidance Document.
This Guidance Document will be supplemented by EPA with
additional information about compliance with data support
requirements. In Union Carbide Agricultural Products Co.
Inc., et. al. v. Ruckelshaus, EPA was enjoined from permitting or
implementing any use of data where the submitter's compensation
is to be determined under §3(c)(l)(D) of FIFRA. EPA is assessing
the implications of the injunction for the reregistration process.
Because this situation is currently unresolved, EPA has decided
to proceed with the requirements in this Guidance Document which
do not relate to compliance with the §3(c)(l)(D) provisions and
to supplement the Document with additional guidance when circum-
stances permit. Failure to comply with the provisions of the
subsequent guidance will also result in issuance by EPA of an
intent to cancel the affected product registration(s).
Registrants are reminded that §6(a)(2) of FIFRA requires
you at any time to submit factual information raising concerns
of possible unreasonable adverse effects of a pesticide. You
should notify the Agency of interim results of studies in
progress if those results show possible unreasonable adverse
effects.
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PRODUCTS SUBJECT TO THE
REGISTRATION STANDARDS PROGRAM
ACTION(S) REQUIRED TO
MAINTAIN REGISTRATION
Products That Do Not Qualify
For The Formulator's Exemption
A. Single Active
Products*
Ingredient
These products must be reregis-
tered. To obtain reregistration,
labeling, packaging and data
requirements must be satisfied
in accordance with the Regis-
tration Standards Guidance
Document.
B. Multiple Active Ingredient
Products
These products will not be
reregistered at this time.
However, generic data required
to continue the registration of
the active ingredient under
review, as described in the
Registration Standards Guidance
Document, will be required and
some labeling precautions may
also be required.
II. Products That Do Qualify For
The Formulator's Exemption
Only when additional restric-
tions or labeling are needed to
protect human health or the
environment will these products
be subject to the Registration
Standard requirements. Affect-
ed products will be dealt with
in a variety of ways, including
but not limited to the Label
Improvement Program and special
intent to cancel notices.
* End-use products of registrants who also produce a manufacturing-
use product will not be required to be reregistered provided that
registrant fulfills the requirements specified in the Guidance
Document for manufacturing-use product(s). Such end-use products
will be subject to the labeling changes required for products in "II"
above. If there are no manufacturing-use products registered by any
company end-use products will be required to be reregistered.
NOTE: If all registrants in "I" above fail to meet the requirements in
I-A and B above, then the registrants in "II" lose their right to
qualify for the formulator's exemption and become subject to the
requirements in I-A and B.
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I. REGULATORY POSITION AND RATIONALE
A. Introduction
This guidance document describes the Agency's regulatory position
on registration ot manutacturing use products (MPs) containing
the insecticide chlorpyrifos. The Agency's position is based on
an evaluation of all accepted uses of registered products under
Sections 3 and 24(c) of the FIFRA with chlorpyrifos as the sole
active ingredient. This document considers known chemical and
toxicological properties of this chemical, as'well as the esta-
blished tolerances for residues in food and feed commodities.
From these considerations the Agency sets forth the data and
labeling requirements that must be met by registrants in order
for the products to be registered or reregistered under this
document. To be registrable under this document, MPs must list
chlorpyrifos as the sole active ingredient. The tables accompany-
ing this document list the data gaps which must be satisfied
through submission of additional information. Future MPs which
differ appreciably from those described in this document may
require that amendments be made to the document to reflect the
differences. Data which were received by the Agency on or after
January 1, 1970 may be compensable.
B. Description of Chemical and Use Profile
Structural Fonaula: Empirical Formula:
c9fillcl3N03ps
mol. wt. 350.6
C.A.S. # 2921-88-2,
Shaughnessy # 059101
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Chlorpyrifos is the American National Standard Institute's accepted
common name for 0 ,0-diethyl-0-(3/5,6-trichloro-2-pyridyl)phosphoro=
thioate. Other names include Brodan, Dowco 179, Dursban, Eradex,
Lorsban, Pyrinex, trichlorpyrphos and phosphorothioic acid 0, 0-
diethyl-0-(3,5 ,6-trichloro-2-pyridinyl) ester.
Initial development of this compound was started in the early
1960's under the code name Dowco® 179. Dow Chemical Company
U.S.A. (Dow) issued a technical brochure in 1956 informing
cooperating researchers and other interested parties of the
physical and chemical properties of the compound. Later that
year, Kenaga and co-workers first described the broad spectrum
activity, persistence and stability of its toxic action under
various conditions. The first registration was issued to Dow on
September 9, 1965 for control of chinch bugs on lawn and turf
grasses. On April 5, 1966 a U.S. Patent was assigned to Dow.
Chlorpyrifos is currently marketed by Dow under the tradenames of
Dursban® for their domestic use products and Lorsban® for their
agricultural line of products.
Technical Chlorpyrifos is a white crystalline solid. It has a
melting point of 41.5-43.5 °C (pure material). Under normal
conditions, Chlorpyrifos is a stable chemical in neutral or
acidic aqueous solutions. This stability decreases with increasing
pH. The chemical can be stored for indefinite periods of time
under proper conditions.
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This chemical is manufactured in the United States solely by Dow.
The following companies produce registered formulation interme-
diates using Dow's technicals: Burroughs Wellcome, Fairfield
American Corp., Insecta-Paint, Inc., McLaughlin Gormley King Co.,
Penick Corp., Southern Mill Creek Products Co., Inc., Stephenson
Chemical Co., Inc., Woodbury Chemical Co. of Homestead, and the
Zoecon Corp. There are 31 Manufacturing Use Products (HP'S)
registered with a range of active ingredient chlorpyrifos from
0.33 to 99.0%.
Chlorpyrifos is manufactured overseas by Makhteshim-Beer Shiva
(Israel). Foreign formulators include the All India Medical
Corporation (India), and Planters Products, Inc., (Philippines).
Chlorpyrifos is registered to control insect pests on the follow-
ing food and feed crops: alfalfa, almonds, apples, asparagus,
bananas, beans (dried and succulent), broccoli, brussels sprouts,
cabbage, cauliflower, Chinese cabbage, citrus fruits, corn (field
and sweet), cotton, cranberries, cucumbers, dill, grapes, lentils,
mint, nectarines, okra, onions (dry bulb), peaches, peas, peanuts,
pears, plums (prunes), pumpkins, radishes, rutabagas, sorghum
(grain), soybeans, strawberries, sugar beets, sunflowers, sweet
potatoes, tomatoes (imported only), turnips, and walnuts. This
chemical is also registered for use as a direct application to
beef cattle and as a sheep, turkey and horse premise treatment,
and for treatment of dogs, dog kennels, dog bedding and quarters,
domestic dwellings, farm buildings, storage bins, and commercial
establishments (including food areas of food handling establish-
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merits), ornamentals, lawns and turf, and terrestrial structures
(termiticide use) and for use in residential and aquatic areas as a
mosquito adulticide and larvicide, respectively.
Chlorpyrifos may be formulated with allethrin, d-trans-allethrin,
s-bioallethrin, fenfluralin, bis(tributyltin)oxide, chlorthal-methyl,
copper 8-quinolinolate, diazinon, dichlorvos, diphenamid, methyl
parathion, monuron, neburon, N-octyl bicycloheptene dicarboximide,
phenothrin, piperonyl butoxide, pyrethrins, resmethrin, siduron,
Sulfox-cide, tetramethirin, thiophanate-methyl.
The applications to food/feed crops may be dormant, delayed dormant,
foliar, seed treatments, or direct at-planting soil applications.
Applications of the pesticide are generally made using ground
equipment although aircraft may be used for corn, cotton, peanuts,
sorghum and aquatic noncrop areas.
There are 1,019 federal section 3 registrations (269 companies),
220 Special Local Need section 24(c) registrations and 45 intra-
state products (14 companies), for chlorpyrifos.
C. Regulatory Position and Rationale
The Agency has reviewed the available data concerning toxicology,
environmental and ecological effects and residue and product chem-
istry. Based on the review and evaluation of these data and other
relevant information on chlorpyrifos, the Agency has determined
that it should continue to allow the registration of chlorpyrifos
after considering the following:
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1. The current data base does not show that any of the
criteria listed in section 162.11(a) of Title 40 of the
U.S. Code of Federal Regulations have been met or exceeded
for any of the uses of chlorpyrifos listed in the Guidance
Document. Neither chlorpyrifos or its major metabolite
3,5,6-trichloro-2-pyridinol (TCP) have been shown to be
neurotoxic, oncogenic, teratogenic, or mutagenic in
studies that have been reviewed to date. Although
chlorpyrifos has been deemed extremely toxic to fish,
birds and other wildlife, and the Agency is concerned
about human exposure from dietary and nondietary sources,
the Agency is not initiating a Special Review at this
time because sufficient data do not exist to support
such action. The most appropriate regulatory action is
to move expeditiously to fill these data gaps. The
Agency will then make a determination as to the future
registrability. of the affected uses.
2. The Agency requires that all products in toxicity cate-
gories I and II bear an appropriate reentry statement.
Since there is a lack of adequate dissipation, exposure,
and acute inhalation data, it is required that registrants
add to the end use product (EP) labels a 24-hour reentry
interval. The state of California has also established
this reentry time interval for chlorpyrifos.
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3. Data are available to assess the acute toxicological
effects of chlorpyrifos to humans. Technical chlorpyrifos
is assigned Toxicity Category II on the basis of acute
oral effects and Toxicity Category III on the basis of
dermal and eye irritation effects. Human hazard precau-
tionary labeling statements inform applicators so as to
minimize the acute hazards associated with these routes
of exposure. The data base for chlorpyrifos includes
among many acute studies three studies submitted by Vel-
sicol Chemical Corp. which were conducted by Industrial
Bio-Test Laboratories, Inc. These studies were validated
by Health Canada.
The Pesticide Incident Monitoring System (PIMS) reports
on chlorpyrifos from 1970 through 1981, contain 319
incidents associated with human exposure, 23 involving
animals, 12 involving environmental contamination, and 1
involving plants. Most of the incidents occurred during
domestic use, while the other incidences occurred with
agricultural uses, formulation, mixing and loading and
during other miscellaneous situations. Most of the
human exposures were the result of inhalation and dermal
exposure. There were three human fatalities caused by
chlorpyrifos and/or chlorpyrifos in combination with
other active ingredients. Two were caused by drinking
the pesticide product(s) and one was caused by inhalation,
dermal and possibly some oral exposure from misuse of
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the product. The Agency is concerned about these
incidences, particularly the relatively high proportion
from domestic uses. The high proportion of incidences
may be indicative of the popularity and broad spectrum
of uses of chlorpyrifos in and around the home, lawn and
garden. Furthermore, the Agency is interested in whether
or not some of the incidences are from normal exposure
routes (dermal and inhalation) with or without typical
dietary exposure of residues. To better understand
exposure levels additional exposure studies are being
required. This is discussed in more detail below.
4. A full tolerance reassessment has not been completed
because of certain residue chemistry and toxicology data
gaps. Further, the preliminary tolerance reassessment
conducted for this document establishes a new, lower no
observable effect level (NOEL) for chlorpyrifos. This
affects the percentage utilized by the accecptable daily
intake (ADI) by increasing it from approximately 94 to
313% for the established tolerances.
The Agency is concerned about this high TMRC to ADI
ratio relative to dietary exposure but more importantly,
the Agency is concerned with total human exposure to
chlorpyrifos and its metabolites, including non-dietary
sources. In addition to having many uses on crops, chlor-
pyrifos is a popular and wide spectrum insecticide that
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is recommended for treatment of lawns, ornamentals,
domestic dwellings, and many other sites such as ed-
ible and non-edible areas of commercial, transportation,
and food handling establishments. Therefore, the Agency
is concerned whether or not the uses of chlorpyrifos
result in significant exposure to certain populations
and whether the exposure level(s) pose unacceptable
risks to these populations.
To better understand, quantify and qualify the total expo-
sure and to evaluate potential risks to applicators,
residents of homes and to the population in general, the
Agency is imposing data requirements for crop and non-crop
uses. Plant and animal metabolism studies are required
to better define the metabolites, especially the major
metabolite, TCP. Also, exposure studies are required
for indoor and lawn applications of chlorpyrifos. The
Agency has already initiated under a separate 3(c)2(B)
action dated February 23, 1984, the requirement for ad-
ditional indoor air monitoring data for chlorpyrifos1
termiticide use. These data are required for submission
to the Agency by mid 1986. The additional required studies
imposed by this Guidance Document are to qualify and
measure parent and metabolite compounds that people will
be exposed to on surfaces and in the air from the other
uses and applications of chlorpyrifos. Regarding the
concerns for total human exposure, the Agency has decided
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that it is not appropriate at this time to initate a
Special Review for chlorpyrifos because of the lack of
sufficient residue and exposure data that are needed to
assess the potential hazards to humans. Upon receipt
and assessment of these required data, the Agency may
find that certain regulatory action may be appropriate
at that time. Also, depending on the results of the
residue chemistry data, additional toxicological infor-
mation on TCP may be required. During this period when
the ADI has been exceeded and the human exposure data are
deficient, the Agency will not establish new tolerances
or register new uses of chlorpyrifos that have a signi-
ficant additive impact on human exposure.
The tolerances for chlorpyrifos residues in or on the
forages and hays of lima beans and snap beans will be
deleted as soon as possible since these commodities are
also included under the .bean forage and hay tolerances.
5. New and/or amended environmental precautions and use
restrictions are being imposed for EPs to reflect the
chemical's hazardous effects to non-target species. The
data base is complete except for a fish embryo-larval
study and a simulated or actual large scale field study
for aquatic organisms, both of which are being required.
Th« available ecological effects <3ata on chlorpyrifos
indicate that it is extremely toxic to aquatic inverte-
brates and other wildlife and that it poses a threat to
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non-target species from both aquatic and general agricul-
tural uses. Therefore, the Agency is requiring field
dissipation data and field studies on aquatic effects of
this chemical for the mosquito, larvae control use. A
full battery of environmental fate studies are required,
as discussed below. Depending on the results of the
dissipation and other environmental fate studies, the
Agency may find it necessary to require additional field
studies to measure effects on aquatic non-target species
from agricultural crop uses.
The Agency lacks data to adequately characterize this
chemicals effects on aquatic species' populations. There-
fore, a Special Review will not be initiated at this time.
We will require these needed studies and impose EP label-
ing requirements to ameliorate the hazards to aquatic and
other wildlife species.
In regard to effects on endangered species, the Agency is
not taking any specific action under this document. The
Agency will be pursuing this under a "cluster approach"
with other pesticides of similar uses. After review of the
cluster, the Agency's current plans are to notify (by early
1986) the states' agricultural extension offices of special
endangered species labeling restrictions and precautions.
These offices will then provide appropriate notification
to potential users of chlorpyrifos.
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6. Available data are insufficient to fully assess the
environmental fate of chlorpyrifos. It is unstable in
water and the rate of hydrolysis increases with tempera-
ture. Degradation in aerobic soils varies depending on
soil types ranging from loamy sand to clay. Degradates
of both aerobic and anaerobic breakdown include 3,5,6-
trichloro-2-pyridinol, 3,5 ,6-trichloro-2-methoxypyridine
and two unidentified compounds. Chlorpyrifos, when
applied to aquatic environments, rapidly dissipates from
the water, but the method of dissipation is not known.
Chlorpyrifos is not mobile in sandy loam and loamy sand
soils, and therefore is not expected to be a potential
hazard to groundwater contamination. However, data on
mobility and leaching are required and should further
define chlorpyrifos' potential to leach into groundwater.
Additional data are required for hydrolysis, photodegra-
dation, aquatic metabolism, dissipation and accumulation
of this compound.
7. The Agency is imposing a crop rotation label restriction
that limits the rotation only with crops that are regis-
tered for chlorpyrifos use because data from a rotational
crop accumulation study indicates that chlorpyrifos
and/or its soil metabolites accumulate in certain tested
crop species. Although this study has some protocol
deficienies it is sufficient enough to support this
restriction. Because of the deficiencies, additional
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studies are required. Until these new data are submitted
and evaluated the Agency is imposing the restrictions
for EPs.
8. MPs containing chlorpryifos as the sole active ingredient
may be registered or reregistered for sale, distribution,
and use under the conditions set forth in this document.
Registrants must provide and agree to develop additional
data, as specified in the tables of this guidance docu-
ment, to maintain existing registrations or to obtain
new registrations of substantially similar products.
9. In accordance with FIFRA, the Agency's policy is not to
cancel or to withhold registration merely for the lack
of certain data (see section 3(c)(2)(B) and 3(c)(7) of
FIFRA). Rather, publication of this guidance document
provides a mechanism for identifying data needs, and
registration under this document allows for the upgrading
of labels during the period in which the required data
are being generated. After the data have been reviewed,
the Agency will then determine how this information will
affect the registration of this chemical.
E. Criteria for Products Subject to the Guidance Document
This guidance document covers all manufacturing use products that
contain chlorpyrifos as the sole active ingredient. Applicants
for registration or reregistration of such products must comply
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with all terms and conditions that are described herein. This
includes making a commitment to fill data gaps on a schedule
specified by the Agency. Also, applicants for reregistration
must follow the instructions that are contained in the guidance
document and complete and submit the appropriate forms within the
specified time frames. End-use products must be in compliance
with the labeling changes specified in this document.
F. Acceptable Ranges and Limits
1. Product Composition Standards
To be fully covered under this guidance document, MPs must
contain chlorpyrifos as the sole active ingredient. Each
product formulation proposed for registration must be
fully described with appropriate certification of limits.
2. Acute Toxicity Limits
The Agency will consider for registration any MP provided
the product is supported by appropriate acute toxicity
data and the labeling for the product bears appropriate
precautionary statements.
3. Use Patterns
To be registered under this document, MPs containing chlor-
pyrifos must be labeled for formulation into other MPs or
end-use products only for the categories listed below.
The attached "EPA Index to Registered Pesticides" entry
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summarizes all currently acceptable uses for single
active ingredient products containing chlorpyrifos,
including sites of application, target pests, dosage
rates, restrictions and limitations and the method and
frequency of application.
-Terrestrial, non-domestic, food uses
-Terrestrial, non-domestic, non-food uses
-Domestic outdoor uses
-Aquatic, non-food uses
-Greenhouse, non-food uses
-Forestry uses
-Indoor uses
G. Required Labeling
All MPs containing chlorpyrifos must bear appropriate labeling as
specified in 40 CFR 162.10, in addition to the following specific
labeling requirements.
1. Labeling Requirements for Manufacturing Use Products
All MPs must state that they are intended only for formula-
tion into other manufacturing use products or end-use
products for uses accepted by the United States
Environmental Protection Agency.
2. Precautionary Statements
Labels for all MPs containing chlorpyrifos must bear state-
ments reflecting the acute human toxicity of this compound,
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The following statements are required on all MP labels:
0 All MPs containing chlorpyrifos 15% and greater must bear
the signal word WARNING. The Hazards to Humans and
Domestic Animals paragraph must read as follows:
"HAZARDS TO HUMANS AND DOMESTIC ANIMALS
WARNING: May be fatal if swallowed. May be fatal if
absorbed through skin or clothing. Avoid
breathing of vapors. Wash throughly after
handling. Do not wear contaminated clothing.
Keep away from food, feedstuffs and water
supplies."
0 All MPs containing less than 15% must bear the signal word
CAUTION. The Hazards to Humans and Domestic Animals para-
graph must read as follows:
"HAZARDS TO HUMANS AND DOMESTIC ANIMALS
CAUTION: May be harmful if swallowed. Do not take
internally. Avoid contact with eyes, skin,
and clothing. Avoid breathing vapors or
dusts. Wash throughly after handling. Keep
away from food, feedstuffs and water supplies.
0 All MPs must bear the following Environmental Hazard
paragraph:
"ENVIRONMENTAL HAZARDS
This pesticide is extremely toxic to fish, birds and
other wildlife. Do not discharge effluent containing
this product into lakes, streams, ponds, estuaries,
oceans, or public waters unless this product is spec-
ifically identified and addressed in a NPDES permit.
Do not discharge effluent containing this product into
sewer systems without previously notifying in writing
the sewage treatment plant authority. For further
guidance/ contact the nearest EPA Regional Office."
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2. Label Requirements for End-Use Products
a. Precautionary Statements
Labels for all EPs containing chlorpyrifos must bear state-
ments reflecting the acute human toxicity of this compound.
The following statements are required on all EP labels:
0 All EPs containing chlorpyrifos 15% and greater must bear
the signal word WARNING. The Hazards to Humans and Domestic
Animals must read as follows:
"HAZARDS TO HUMANS AND DOMESTIC ANIMALS
•WARNING: May be fatal if swallowed. May be fatal if
absorbed through skin or clothing. Avoid
breathing of vapors. Wash throughly after
handling. Do not wear contaminated clothing.
Keep away from food, feedstuffs and water
supplies."
0 The following reentry statement must appear on the agricul-
tural use labels at the end of the paragraph for HAZARDS
TO HUMANS.
"Do not allow reentry into treated areas within 24 hours
unless protective clothing is worn. Protective clothing
consists of at least a hat or other suitable head cover-
ing, a long sleeved shirt and long legged trousers or
a coverall type garment (all of closely woven fabric
covering the body, including the arms and legs), shoes
and socks."
0 All EPs containing less than 15% must bear the signal word
CAUTION. The Hazards to Humans and Domestic Animals
paragraph must read as follows:
19
-------
"HAZARDS TO HUMANS AND DOMESTIC ANIMALS
CAUTION: May be harmful if swallowed. Do not take
internally. Avoid contact with eyes, skin, and
clothing. Avoid breathing vapors or dusts. Do
not wear contaminated clothing. Wash throughly
after handling. Keep away from feed, foodstuffs
and water supplies."
All EPS must bear an Environmental Hazard paragraph. This
paragraph must be prefaced with the heading "ENVIRONMENTAL
HAZARDS" and read as listed below:
(a) Aquatic End Use:
"This pesticide is extremely toxic to fish, birds,
and other wildlife. Fish and other aquatic organisms
may be killed at application rates recommended on
the label. Consult your State Fish and Game Agency
before applying this product to determine this
products impact on aquatic life forms. Cover or
incorporate spills while loading. Do not contaminate
water by cleaning of equipment or disposal of waste."
The following statement must appear in the directions
for use section of the label: "For use only in logging
ponds, standing water, temporary rain pools, intermit-
tantly flooded areas, stagnant water and other similar
non-crop areas that serve as mosquito breeding sites.
Shrimp and crab may be killed at application rates
recommended on this label. Do not apply where these
are important resources. Do not apply to water used
for irrigational, recreational or domestic uses."
(b) Terrestrial End Use (except forest use):
"This pesticide is extremely toxic to fish, birds,
and other wildlife. Do not apply directly to water.
Drift and runoff from treated areas may be hazardous
to aquatic organisms in adjacent aquatic sites. Cover
or incorporate spills. Do not contaminate water by
cleaning of equipment or disposal of waste."
20
-------
(c) Forest Use:
"This pesticide is extremely toxic to fish, birds,
and other wildlife. Do not apply directly to water
except under the forest canopy. Drift and runoff
from treated areas may be hazardous to aquatic
organisms in adjacent aquatic sites. Cover or
incorporate spills. Do not contaminate water by
cleaning of equipment or disposal of waste."
0 The following labeling statements are required for the
uses listed below:
(a) Cattle dip:
Because of the formation of an unidentified metabolite
generated in cattle dipping solutions the following
statement is required in the use directions:
"The addition of superphosphate into the dipping
solution enhances the stability of the solution
and is therefore recommended."
(b) The label directions for direct application to animals
should state,
"Apply only this pesticide product to the animal
during the recommended treatment schedule. Do
not apply other pesticide products."
(c) Crop uses (agricultural and home garden EPs):
"Plant, in chlorpyrifos treated soils, only those
crops listed on this or other chlorpyrifos product
labels."
H. Tolerance Reassessment
Tolerances have been established (21CFR 193.25, 21CFR 561.98, 40
CFR 130.342) for chlorpyrifos and its metabolite 3,5,6-trichloro-
21
-------
2-pyridinol (TCP) in or on the following raw or processed agricul-
tural commodities: rutabagas, sugar beet roots and tops, seed and
pod vegetables, dried sugar beet pulp and molasses, onions (dry
bulb), bean forage, pea forage, tomatoes, cucumbers, radishes,
dill, pumpkins, citrus fruits and oil, dried citrus pulp, apples
and dried apple pomace, pears, cherries, nectarines, peaches,
plums (fresh prunes), grapes, and dried grape pomace, almonds and
almond hulls, walnuts, corn (fresh and grain), corn forage and
fodder, corn oil and soapstock, kiwi fruit, mint hay and oil,
peanuts, peanut hulls, and peanut oil, sunflower seeds and hulls,
sorghum milling fractions, milkfat, eggs, poultry fat, cattle
meat and meat by-products of cattle, goats, hogs, horses and
sheep.
Although no additional residue data are required for the following
crops, the following amendments or new tolerances which reflect
the data base are required since these were included in the now
obsolete seed and pod vegetable group: cowpeas (0.1 ppm), dry
beans (0.1 ppm), lentils(0.1 ppm), dry and succulent peas (0.1
ppm), cowpea forage (1 ppm) and lentil forage (1 ppm). Petitions
to amend or establish these tolerances must be submitted within
six months from the date of this document. The tolerances for
chlorpyrifos residues in or on the forages and hays of lima beans
and snap beans also are included under the bean forage and hay
tolerances. Therefore, the Agency will act to delete these
duplicative tolerances.
22
-------
Additional plant and animal metabolism studies are required to
fully qualify and quantify the parent compound and its metabolites,
including the major metabolite TCP in ruminants and poultry and
in corn and representative root and legume crops. Also, additional
specific crop residue data are required to support the existing
tolerances for chlorpyrifos residues in or on the following com-
modities: sweet potatoes (or a 125-day PHI must be established),
turnip roots and greens, broccoli, brussels sprouts, cabbage,
Chinese cabbage, cauliflower, lima beans, snap beans, soybeans,
bean hay, cowpea hay, lentil hay, pea hay, soybean forage, hay and
straw, peppers, cranberries, strawberries, sorghum grain, sorghum
forage and fodder, alfalfa forage and hay, bananas (only regulatory
information from exporting countries is required), cottonseed,
figs, and okra.
The primary toxicological concern associated with chlorpyrifos is
acetylcholinesterase (ChE) inhibition. Over the years, the rele-
vance of each of the ChE determinations (plasma, RBC and brain)
to human health has been the subject of much scientific debate.
A recent WHO monograph (GS0100206) stated that erythrocyte (RBC)
cholinesterase inhibition may be a better indicator of this
biochemical effect of anti-ChE pesticides than plasma ChE because
RBC ChE is thought to be biochemically identical to ChE at the
synapse whereas plasma ChE is considered to be quite different.
However, brain ChE may be inhibited in the absence of either RBC
or plasma ChE inhibition and the pattern of inhibition appears to
vary from one anti-ChE agent to another. Plasma cholinesterase
23
-------
inhibition is often a more sensitive indicator of anti-ChE acti-
vity than RBC or brain ChE inhibition, although its relevance to
human health has not been clearly established. Marked inhibition
of plasma ChE (in the absence of RBC ChE inhibition) coincides
with the level at which the classic clinical signs of ChE inhibi-
tion are noted using chlorpyrifos. A human cholinesterase study
(GS0100200) demonstrates a Lowest Observed Effect Level of 0.1
mg/kg/day based on 9 days of exposure. The NOEL in this study is
0.03 mg/kg/day (based on 20 days of exposure). Previously, the
Agency had relied upon a 2-year rat feeding study which had a
NOEL for plasma and RBC CHE inhibition of 0.1 mg/kg/day. Although
the human study was of short duration and used only four subjects
per dose level/ it is used to set the ADI because the findings
are similar to the animal studies and do not require an inter-
species extrapolation. The ADI has been set at 0.003 mg/kg/day
from a NOEL of 0.03 mg/kg/day and a 10-fold safety factor. The
TMRC has been recalculated and will utilize approximately 313% of
the ADI for the established tolerances.
The Agency is concerned about the resulting expansion of the TMRC
significantly above the ADI, however the Agency still believes
that the established tolerances offer sufficient protection to
the public who consume chlorpyrifos and TCP residues in their
diet. The actual residue levels to which the public is likely to
be exposed are considerably less than indicated by the TMRC for
reasons which include the following:
24
-------
- Not all of the planted crop for which a tolerance has been
established is treated with the pesticide.
- Most treated crops have residue levels which are below the
established tolerance levels.
- Processing or time to market often result in further residue
reduct ions.
- Preparing food for consumption often results in residue
reduct ions .
- Not all crops contributing to the TMRC (PADI) are likely to
be consumed by an individual.
- Market basket surveys conducted by FDA indicate that little
if any real pesticide residues actually remain in/on food
as consumed by the general population. For example, of the
more than 75,000 samples which were analyzed by FDA, only
about 1,300 samples showed findings greater than 0.01 ppm.
- The TMRC and tolerances include the TCP metabolite which
does not cause CHE inhibition and therefore does not contri-
bute to the NOEL which the ADI is based on.
The U.S. tolerance expression for chlorpyrifos currently includes
TCP because there is insufficient residue and toxicology data to
adequately characterize this major metabolite. If sufficient data
were provided, the Agency could reconsider the necessity of its
inclusion in the tolerance expression. Obviously, some relief
could be gained by lowering the percentage that is utilized by the
ADI, and there could be more compatability with the maximum residue
levels (MRL's) of Codex Alimentarius and/or the tolerances of
25
-------
Canada and Mexico which include only chlorpyrifos per se.
International Tolerances
The following International Tolerances exclude the principal
metabolite of chlorpyrifos, TCP, in their tolerance expression,
Crop
Apples
Bean forage
Broccoli
Brussels sprouts
Cabbage
Cattle meat & meat
by-products
Cauliflower
Corn forage
Corn (fresh & grain)
Dry beans
Kiwi fruit
Lima beans
Onions
Peaches
Pears
Peas
Snap beans
Sorghum forage
Sorghum grain
Tolerance (ppm)
Canada
0.1
0.1
0.1
1
0.1
0.1
0.1
0.1
0.1
0.1
0,01
0.1
Mexico
0.05
1
0.1
0.1
0.05
0.05
0.05
1.5
0.75
26
-------
Strawberries
Sugar beets (roots)
Sunflower seed
Sweet potatoes
0.1
0.1
0.1
0.1
The latest Codex Alimentarius entry for residues of chlorpyrifos
per se are:
Crop
Apples
Cabbage
Cattle meat
Cauliflower
Chinese cabbage
Citrus fruits
Cottonseed & oil
Dry beans
Eggs
Grapes
Kiwi fruit
Lima beans
Milk
Mushrooms
Onions
Pears
Peppers
Maximum
Residue Limit
(Mg/Kg)
1
0.05
2
0.05
1
0.3
0.05
0.2
0.05
1
2
0.2
0.01
0.05
0.05
0.5
0.5
27
-------
Poultry meat 0.1
Sheep meat 0.2
Snap beans 0.2
Sugar beets (roots) 0.05
Tomatoes 0.5
Turkey meat 0.2
28
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TABLE OF CONTENTS TO SITE LOCATION
Site Name Page
TERRESTRIAL FOOD CROP
(Agricultural Crops)
Almond
Apple
Banana
Beans
Broccoli
Brussels Sprouts
Cabbage
Cauliflower
Corn
Cotton
Cucumber
Dill
Lentils
Nectarines
Okra
Peach
Peanuts
Pear
Peas
Plum
Prune
Pumpkin
Radish
Rutabagas
Sorghum (grain)
3
3
3
4
4
4
4
4
5
8
10
10
10
10
10
11
11
13
10
13
13
10
13
14
15
29
-------
1ABLE OF CONTENTS TO SITE LOCATION
Site Name Page
Soybeans 15
Sugar Beets 16
Sweet Potato 16
TERRESTRIAL NON-FOOD CROP
(Ornamental Plants and Forest Trees)
Cotton wood (including nursery stock) 24
Elm 24
Golf Course Turf 28
Lawas 28
Ornamental Deciduous Trees 25
Ornamental Evergreens 25
Ornamental Herbaceous Plants 25
Ornamental and/or Shade Trees 25
Ornamental Tuff 28
Ornamental Woody Shrubs 25
Ornamental Woody Vines 25
Ornamental Plants (nursery stock) 26
Pine 26
Prunus 26
(Noncrop, Wide Area, and General Indoor/Outdoor Treatments)
Noncrop Areas (including compsites, paths, picnic areas,
recreational areas, roadsides, and trails) 30
Recreational Areas 32
Residential Areas 43
Uncultivated Sonagrlcultural Areas 30
30
-------
TABLE OF CONTENTS TO SITE LOCATION
Site Name ^ Page
DOMESTIC OUTDOOR
(Ornamental Plants and Forest Trees)
Lawns 28
Also refer to TERRESTRIAL NON-FOOD CROP (Ornamental Plants) 24
(Household)
Domestic Dwellings (Outdoor) 39
(Wood or Wood Structure Protection Treatments)
Terrestrial Structures 43
AQUATIC NON-FOOD CROP
(Aquatic Sites)
Aquatic Areas 32
Catch Basins 34
Cesspools 34
Flooded Areas (including flooded noncrop areas) 32
Industrial Waste Water Impoundments 35
Intermittently Flooded Areas (including culverts, open sheet
catch basins, rain barrels, hollow stumps, temporary rain
pools, tree holes, woodland pools) 32
Log Ponds 32
Septic Tanks 34
Sewage Systems (including sewage ponds and waste disposal ponds
and lagoons)35
Stagnant Water 32
Standing Water 32
FORESTRY
Pine (including Southern Pines) 31
31
-------
TABLE OF CONTENTS TO SITE LOCATION
Site Name - Page
INDOOR
(Processed or Manufactured Products, and Food or Feed Containers or
Dispensers)
Storage Bins (Empty) 50
(Pets and Domestic Animals)
Beef Cattle 17
(Animals and Their Man-Made Premises)
Dogs 23
Dog Kennels 21
Horse Stables 20
Pet Bedding 21
Pet Quarters - 21
Turkey Pen 19
(Agricultural Premises and Equipment)
Farm Buildings 20
Greenhouse Bench 21
Nursery Bench 21
Potting Media 21
Potting Soil 21
(Household)
Domestic Dwellings (Indoor) 35
(Vfood or Wood Structure Protection Treatments)
Terrestrial Structures 43
(Commercial and Industrial Uses)
CoBBercial, Institutional, and Industrial Areas (Indoor, areas
other than edible product areas)54
Commercial Transportation Facilities (Indoor, edible product
areas) 51
32
-------
TABLE OF CONTENTS TO SITE LOCATION
Site Name Page
Commercial Transportation Facilities (Indoor, areas other than
edible product areas) 54
Eating Establishments (Indoor, edible product areas) 51
Eating Establishments (Indoor, areas other than edible product
areas) 54
Food Handling Establishments (Indoor, edible product areas) 51
Food or Grocery Marketing Storage Plants/Areas (Indoor, areas
other than edible product areas) 54
Food Processing, Handling, and Storage Plants/Areas (Indoor,
edible product areas) 51
Food Processing, Handling, and Storage Plants/Areas (Indoor,
areas other than edible product areas)54
Hospitals (Indoor, edible product areas) 35
Telephone Pedestals (buried) , 57
33
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r- EPA Index to Pesticide Chemicals
c059101 CHLORPYRIFOS*
TYPE PESTICIDE: Insecticide, Acaricide
FORMULATIONS :
Tech (942, 992);
FI (0.5 Ib/gal, 2.7 Ib/gal, 4 Ib/gal, 6 Ib/gal, 0.33%, 12, 102, 15%, 25%,
44.82, 502, 52.42);
D (0.12, 252);
G (0.0752, 0.142, 0.22, 0.232, 0.32, 0.33%, 0.42, 0.462, 0.472, 0.52,
0.512, 0.522, 0.552, 0.572, 0.5752, 0.62, 0.652, 0.72, 0.722, 0.752, 0.8%,
0.852, 0.922, 12, 1.142, 1.162, 1.22, 1.342, 1.35%, 22, 2.22, 2.3%, 2.322,
2.52, 52, 102, 152);
P/T (1%);
WP (2.32%, 252, 50%);
Heap (10.62);
Impr (0.5%, 102);
EC (0.156 Ib/gal, 0.33 Ib/gal, 0.45 Ib/gal, 0.5 Ib/gal, 0.667 Ib/gal,
1 Ib/gal, 1.2 Ib/gal, 2 Ib/gal, 4 Ib/gal, 0.51%, 2.2%, 2.35%, 2.85%, 5.3%,
5.42, 5.652, 6%, 6.6%, 6.7%, 6.792, 12.3%, 14.45%, 20%, 22.4%, 23.7%,
24.92, 25%, 41.22);
SC/L (6 Ib/gal);
RTU (0.073 Ib/gal, 0.146 Ib/gal, 3.8 Ib/gal, 0.05%, 0.25%, 0.5%, 0.862);
PrL (0.09%, 0.222, 0.5%)
GENERAL WARNINGS AND LIMITATIONS: Do not use in dairy barns, poultry
houses, or inside homes or buildings while food is processed. Chlorpyri-
fos is toxic to fish and crustaceans. Indoor use of chlorpyrifos formula-
tions above 0.5 percent active ingredient is limited to professional pest
control operators. For mosquito control, chlorpyrifos can be applied only'
by or under the supervision of public health organizations, mosquito
abatement districts or other trained personnel responsible for insect
control programs. Wear suitable protective equipment and clothing when
using or handling chlorpyrifos to help avoid exposure to eyes and skin.
As a minimum, chemical worker's goggles, neoprene or natural rubber gloves
and footwear, a long-sleeved shirt and long-legged pants or coveralls are
recommended. To avoid breathing spray mist during application in confined
areas, wear a mask or respirator of a type recommended by National Insti-
tute of Occupational Safety and Health for filtering spray mists and
organic vapors.
Bee Caution:
This product is highly toxic to bees exposed to direct treatment on bloom-
ing crops or weeds. Do not apply chlorpyrifos or allow it to drift to
blooming crops or weeds while bees are actively visiting the treatment
area.
*Dursban
0,0-diethyl 0-(3,5,6-trichloro-2-pyridyl) phosphorothioate
Issued: 10-29-81 III-059101-1
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
GENERAL WARNINGS AND LIMITATIONS (continued)
Agricultural Crop Tolerances:
Alfalfa, green forage - ^ ppm
Alfalfa, hay - 15 ppm
Chinese Cabbage - 2 ppm
Citrus, pulp, dried (intended for animal feed) - 15 ppm
Mint, hay - 1 ppm
Mint, oil - 10 ppm
Onions, dry bulb - 0.5 ppm
Pepper - 1 ppm
Strawberry - 0.5 ppm
Tomatoes - 0.5 ppm
Turnips, green -1 ppm
Turnips, roots - 3 ppm
Wheat, milling fractions, except flour - 3 ppm
Wheat - 1 ppm (temporary tolerance)
Wheat, straw - 3 ppm (temporary tolerance)
Livestock and Poultry Tolerances;
Eggs - 0.1 ppm
Goats (fat, meat, meat byproducts) - 1 ppm
Hogs (fat, meat, meat byproducts) - 0.5 ppm
Milk, fat [0.02 ppm (N) in whole milk] - 0.5 ppm
Poultry (fat, meat, meat byproducts) - 0.5 ppm
Sheep (fat, meat, meat byproducts) - 1 ppm
Refer to the Code of Federal Regulations [CFR 21, Parts 170-199, (Revised
as-of April 1, 1980)] for food additive tolerance of chloryprifos.
Definition of Terms:
*Tablespoons actual. A hypothetical quantity computed by multiplying the
number (or equivalent number) of tablespoons of product by the concentra-
tion of chlorpyrifos in the femulation.
**Computed from tablespoon/teaspoon dosage.
***Exact computation of actual dosage is not possible because of the lack
of weight/volume information on the label. Extrapolation from other form-
ulations reveals that the dosage from this label appears to fall within
the range shown by formulations with known weight/volume ratios.
Claims for pest control limited to suppression of population are indicated
by parenthesized pest name.
Issued: 10-29-81 III-059101-2
-------
/03001AA
Site and Pest
AGRICULTURAL CROPS
Almond
ITBCABA
ITAMABA
IRAKBYA
/04001AA
Cutworms
Peach twig borer
San Jose scale
Apple
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.05 ppm (almonds)
0.05 ppm (almond, hulls)
Dormant or delayed dormant applica-
tion through 0.5 pound per acre. Do
not make more than 1 application
during the dormant or delayed dor-
mant periods.
Do not allow meat or dairy animals
to graze in treated orchards.
0.25-0.5 lb/ Dormant or delayed dormant applica-
100 gal/A tion. Apply to the entire tree to
(4 Ib/gal EC) the point of runoff. Use the higher
rate for severe infestation. Tank
mix with oil.
0.05 ppm
Dormant or delayed dormant applica-
tion through 0.5 pound per acre. Do
not make more than 1 application
during the dormant or delayed dor-
mant periods.
Do not allow meat or dairy animals
to graze in treated orchards.
ITBCABA
IRACBQA
IRAKBYA
/06002AA
Cutworms
Rosy apple aphid
San Jose scale
Banana
0.25-0.5 lb/
100 gal/A
Dormant or delayed dormant applica-
tion. Apply to the entire tree to
INASAWA
Banana root borer
(4 Ib/gal EC) the point of runoff. Use the higher
rate for severe infestation. Tank
mix with oil.
0.05 ppm (banana pulp with peel
removed)
0.25 ppm (banana, whole)
Banded soil application through 3
grams per plant.
3 g./plant Soil application (band). Apply a 6
(52 G) inch band around the base of each
plant. Repeat at 6 month intervals
if trap counts indicate.
Issued: 10-29-81
III-059101-3
-------
/28001AA
/28005AA
Site and Pest
Beans
INAKABA
IOACAHA
Seedcorn beetle
Seedcorn maggot
/13005AA
/13006AA
/13007AA
/13008AA
Broccoli
Brussels Sprouts
Cabbage
Cauliflower
IOACABA
Root maggots
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.05 ppm beans (lima)
0.05 ppm beans (snap)
1 ppm beans (lima, forage)
1 ppm beans (snap, forage)
0.1 ppm (bean seeds)
Seed treatment through 1 ounce per
100 pounds of seed.
Do not mix the seeds and chlorpyri-
fos with bare hands. Do not use
treated seed for human consumption,
as feed for livestock or poultry, or
for oil purposes.
1 oz/100 Ib Slurry treatment of seeds prior to
seed planting. Disperse in a water solu-
(25-50% WP) tion containing 0.5 percent (by
weight) of any acceptable sticking '
agent. Use 12 to 15 fluid ounces of
solution for each 100 pounds of seed
to be treated. Mix the slurry with
the seed using a rotating blender or
other mixing equipment that will en-
sure each seed is uniformly coated.
Dry the seed immediately after
treatment. Treated seeds may be
stored for up to 14 months without
loss of insecticidal effectiveness.
Hay be tank mixed with chloroneb,
thiram, or captan.
2 ppm
Banded soil application (at plant-
ing) through 1.65 ounces per 1,000
feet of row not to exceed 2.25
pounds per acre. Do not make more
than 1 application during the grow-
ing season.
0.81-1.61 oz/ Soil application at planting (band).
1,000 ft row Apply a 2 to 4 inch band ahead of
(152 G) the planter shoe or in front of the
press wheel to achieve shallow in-
corporation.
Issued: 10-29-81
III-059101-4
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPY.RIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Broccoli cluster (continued)
/28005AA
Brussels Sprouts
Cabbage
Cauliflower
Corn
Issued: 10-29-81
0.8-1.65 oz/ Soil application at planting (band).
1,000 ft row For direct seeded crops, apply a 2
(4 Ib/gal EC) to 4 inch band over the row either
ahead of the planter shoe or in
front of the press wheel to achieve
shallow incorporation. Apply in a
minimum of 20 gallons of water per
acre.
Transplant water application. Apply
as soil drench to transplants immed-
iately after setting. Apply in a
minimum of 20 gallons of total
drench per acre. Apply to soil at
the base of the plants.
See Broccoli cluster.
See Broccoli cluster.
See Broccoli cluster.
0.1 ppm field, grain, fresh (includ-
ing sweet kernels and cob with husks
removed), fodder, forage
Foliar application (postemergence)
through 1.5 pounds per acre.
Broadcast soil application (pre-
plant) through 2 pounds per acre.
Banded soil application (at plant-
ing) through 2.4 ounces per 1,000
feet of row.
Banded soil application (postemer-
gence through 1.2 ounces per 1,000
feet of row.
For row treatments, amount applied
per acre varies according to row
spacing.
Do not make more than 1 application
during the growing season.
50 day pregrazing or preharvest in-
terval for forage, fodder, silage,
or grain, to be fed to dairy or meat
animals.
Control of soil insects may be re-
duced in soils containing over 10
percent organic matter or soils
under very dry conditions. Consult
UI-059101-5
-------
Site and Pest
Corn (continued)
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Fprmulation(s)
ITBCCFA
INASDUA
ITBCABA
ITBMBOA
IVABAAA
INASDUA
INAMADA
INBPAAA
INAVAAA
ITBCABA
INASDUA
ITBMBOA
ITBCABA
INAMBLC
INAMBMC
INAMBOC
IJDAAAA
Armyworm
Billbugs
Cutworms
Lesser cornstalk
borer
Grasshoppers
Billbugs
Flea beetles
(1arvae)
White grubs
Wireworms
Cutworms
Billbugs
Lesser cornstalk
borer
Cutworms
Northern corn root-
worm (larvae)
Southern corn root-
worm (larvae)
Western corn root-
worrn (larvae)
Symphylans
0.5-1 Ib/A
(4 Ib/gal EC)
1-1.5 Ib/a
(4 Ib/gal EC)
0.25-0.5 Ib/A
(4 Ib/gal EC)
2 Ib/A
(15% G)
1-2 Ib/A
(15% G)
your State Agricultural Extention
Service for information concerning
soil insect control.
Foliar application. May be applied
by aircraft in a minimum of 2 gal-
lons of water per acre. Apply when
field counts indicate. For cut-
worms, apply when soil is moist and
pest active or near soil surface.
If soil is dry, cloddy, or crusty at
time of application cutworms may be
protected from the spray and effec-
tiveness reduced. If this condition
exists, cultivation by rotary hoe or
equivalent equipment before or soon
after application may improve con-
trol.
Preplant soil application (broad-
cast). Incorporate the granules
into the top 4 to 6 inches of soil.
i onn r S°Ll application at planting (band).
1,000 ft row Apply in a 6 to 7 inch band over the
(15% G) row between the planter shoe and
press wheel. Incorporate granules
1.2 oz/1,000 into the top 1 inch of soil. If
ft row cutworm damage continues as a result
(15% G) of dry soil conditions, a rescue
treatment may be needed to control
0.9-1.2 oz/ surviving cutworms.
1,000 ft row
(10-15% G)
1.2-1.8 oz/
1,000 ft row
(15% G)
Issued: 10-29-81
III-059101-6
-------
IHAVAAA
INAKABA
INBPAAA
IOACAHA
INAVAAA
INAVAAA
IHAMBHA
ITBCABA
INAVAAA
IHAMBLC
INAMBMC
INAMBOC
IOACAHA
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Corn (continued)
Pest list continued from previous page.
Wireworms
Seedcorn beetle
White grubs
Seedcorn maggot
(Wireworms)
Wireworms
Corn rootworms
Cutworms
Wireworms
Northern corn root-
worm (larvae)
Southern corn root-
worm (larvae)
Western corn root-
worm (larvae)
Seedcorn maggot
2.4 oz/1,000
ft row
(15% G)
1.2-2.4 oz/ Soil application at planting (band).
1,000 ft row Apply granules in the furrow with
(15% G) the seed either through or directly
behind the planter shoe.
1.2 oz/1,000
ft row
(15% G)
2.4 oz/
1,000 ft row
(15% G)
1-2 Ib/A Preplant soil application (broad-
(4 Ib/gal EC) cast). Apply in a minimum of 10
gallons of water per acre. Incor-
porate into the top 2 to 4 inches
of soil using disk or cultivator.
0.9-1.2 oz/ Postplant soil application (band).
1,000 ft row Apply during cultivation. Apply
(15% G) granules over the row or sidedress
both sides of the row. Cultivate
into the soil.
2 oz/100 Ib Planter box seed treatment. Do not
seed mix with bare hands. Do not use
(25% D) treated seed for human consumption,
as feed for livestock or poultry, or
for oil purposes.
Refer to Beans for additional information.
Issued: 10-29-81
III-059101-7
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EPA Index to Pesticide Chemicals
/28007AA
ITBCCFA
IRACAOA
IQAMAYA
IQAMARA
ITABACA
IMOAAAA
INASAHA
ITBCBOA
ITAYAHA
ITBCABA
ITAMADA
ILAVAAA
ITBCCFA
INASAHA
ITBCBOA
IQAMAYA
IQAMAAA
ILAVAAA
Site and Pest
Cotton
Armyworm
Cotton aphid
Cotton fleahopper
Lygus bugs
Saltmarsh cater-
pillar
Thrips
Boll weevil
Bollworm
(Heliothis spp. )
(Cotton leafperfor-
ator)
Cutworms
Pink bollworm
(Spider mites)
Annyworm
Boll weevil
Bollworm
(Heliothis spp. )
Cotton fleahopper
Plant bugs (includ-
ing lygus and
mirids)
Spider mites
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.5 ppm (cottonseed)
14 day preharvest interval through 1
pound per acre for foliar applica-
tion.
Do not allow livestock to graze in
treated areas. Do not feed gin
trash or treated forage to live-
stock. May be applied by aircraft
in a minimum of 1 gallon of water
per acre. Fly at a height of 5 to
15 feet. Orientate position of
nozzles to produce a droplet size
of 100 to 200 microns. For ground
equipment use flat fan or disc core
hollow cone nozzles spaced a maximum
of 20 inches apart on the boom.
Maintain spray pressure at 40 to 60
pounds per square inch and droplet
size of 100 to 200 microns. Unless
otherwise specified apply when field
counts indicate and repeat as
needed.
0.5-1 Ib/A Use limited to AZ and CA.
(4 Ib/gal EC) Foliar application. For bollworms,
scout 2 times per 7 day intervals
and treat when instars are less than
0.25 inch in length. For spider
mites, when large numbers of eggs
are present, make a second applica-
tion 3 to 5 days later to control
1 Ib/A newly hatched nymphs.
(4 Ib/gal EC)
0.25-0.5 Ib/A Foliar application. Tank mix with
(4 Ib/gal EC) 0-ethyl C~[4-(methylthio phenyl]
S-propyl phosphorodithioate.
0.5 Ib/A Foliar application. Tank mix with
(4 Ib/gal EC) emulsifiable formulations of 0,0-di-
methyl 0-p-nitrophenyl phosphorothi-
oate and toxaphene or emulsifiable
formulations of 0,0-dimethyl 0-p-
nitrophenyl phosphorothioate and
0-ethyl O-(p-nitrophenyl) phenyl-
phosphonothioate.
Issued: 10-29-81
III-059101-8
-------
Site and Pest
Cotton (continued)
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.5-1 Ib/A Foliar application. Tank mix with
(4 Ib/gal EC) cyano (3-phenoxyphenyl)methyl 4-
chloro—alpha-(1-raethylethy 1)benzene-
acetate.
ITBCCNA
INASAHA
ITBCBOA
ITBCABA
ITAMADA
ITABACA
IRACAQA
ITBCCOA
ILAVAAA
IMQAAAA
ITBCCQA
IQAMAYA
IQAMAAA
0.75-1 Ib/A Use limited to states other than AZ
(4 Ib/gal EC) and CA.
Foliar application. For bollworms,
scout 2 times per 7 days intervals
and treat when instars are less than
0.25 inch in length. For spider
mites, when large number of eggs are
present, make a second application
3 to 5 days later to control newly
0.25-0.5 Ib/A hatched nymphs.
(4 Ib/gal EC)
Beet armyworm
Boll weevil
Bollworm
(Heliothis spp.)
Cutworms
Pink bollworm
Saltmarsh cater-
pillar
Cotton aphid
Fall armyworm
Spider mites
Thrips
Yellowstriped army-
worm
Cotton fleahopper 0.188-0.5 Use limited to states other than AZ
Plant bugs (includ- Ib/A and CA.
ing lygus and (4 Ib/gal EC) Foliar application. The low dosage
mirids) will not achieve the high degree of
control as the higher rate but will
minimize the damage done by plant
bugs and cotton fleahopper plus al-
low beneficial insects to survive,
build up, and be available to aid
in the control of bollworms.
Issued: 10-29-81
III-059101-9
-------
EPA Index to Pesticide Chemicals
/10010AA
/08015AA
/15011AA
/15015AA
/28075AA
/10011AA
/28023AA
INACABA
IOACAHA
/05003AA
ITBCABA
ITAMABA
IRAKBYA
Site and Pest
Cucumber
Dill
Lentils
Okra
Peas
Pumpkins
Seedcorn beetle
Seedcorn maggot
Nectarines
Cutworms
Peach twig borer
San Jose scale
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.1 ppm (vegetable seed)
Seed treatment through 1 ounce per
100 pounds of seed.
Do not mix the seeds and chlorpyri-
fos with bare hands.
Do not use treated seed for human
consumption, as feed for livestock
or poultry, or for oil purposes.
1 oz/100 Ib Slurry treatment of seeds prior to
seed planting. Disperse in a water solu-
(50% WP) tion containing 0.5 percent (by
weight) of any acceptable sticking
agent. Use 12 to 15 fluid ounces
of solution for each 100 pounds of
seed. Mix the slurry with the seed
using a rotating blender or other
mixing equipment that will ensure
each seed is uniformly coated. Dry
the seed immediately after treat-
ment. Treated seeds may be stored
for up to 14 months without loss of
insecticidal effectiveness. May be
tank mixed with chloroneb, thiram,
or captan.
See Cucumber cluster.
See Cucumber cluster.
0.05 ppm
14 day preharvest interval through
3 pounds per 100 gallons for bark
application.
Do not make more than 1 application
during the growing season. Do not
allow meat or dairy animals to graze
in treated orchards.
0.25-0.5 Ib/ Dormant or delayed dormant applica-
100 gal/A tion. Apply to the entire tree to
(4 Ib/gal EC) the point of runoff. Use the higher
rate for severe infestation. Tank
mix with oil.
Issued: 10-29-81
111-059101-10
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Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Nectarines (continued)
[TBQAHA
Peachtree borer
3 lb/100 gal Bark application. Apply before new-
(4 Ib/gal EC) ly hatched larvae enter the trees.
Apply as a coarse, low pressure
spray to give uniform coverage of
tree trunks. Thoroughly wet all
bark areas from scaffold branches to
ground. Do not allow spray to con-
tact fruit. Consult your State
Agricultural Extension Service for
proper timing of application in your
area.
/05004AA
ITBCABA
ITAMABA
IKAKBYA
ITBQAHA
Cutworms
Peach twig borer
San Jose scale
Peachtree borer
See Cucumber cluster.
0.05 ppm
14 day preharvest interval through
3 pounds per 100 gallons for bark
application.
Do not make more than 1 application
during the growing season. Do not
allow meat or dairy animals to graze
in treated orchards.
0.25-0.5 lb/ Dormant or delayed dormant applica-
100 gal/A tion. Apply to the entire tree to
(4 Ib/gal EC) the point of runoff. Use the higher
rate for severe infestation. Tank
mix with oil.
3 lb/100 gal Bark application. Apply before new-
or ly hatched larve enter the trees.
0.5 oz/gal Apply as a coarse, low pressure
[0.25-8 gal/ spray to give uniform coverage of
tree] tree trunks. Thoroughly wet all
(0.5-4 Ib/gal bark areas from scaffold branches to
EC) ground. Do not allow spray to con-
tact fruit. Consult your State
Agricultural Extension Service for
proper timing of application in your
area.
Issued: 10-29-81
III-059101-ll
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest Dosages and Tolerance, Use, Limitations
Foramlation(s)
728015AA Peanuts 0.5 ppm (peanuts)
15 ppm (peanut hulls)
21 day preharvest interval through
2 pounds per acre for foliar appli-
cation. Do not exceed 4 pounds per
acre per growing season for foliar
application (broadcast or directed
spray). Do not make more than 1
application per growing season as a
directed spray.
Banded soil application (prior to or
at pegging) through 2.25 ounces per
1,000 feet of row. Do not make more
than 1 application during season for
banded soil application. For row
treatments, amount applied per acre
varies according to row spacing. Do
not feed treated peanut forage of
hay to meat or dairy animals. For
emulsifiable concentrate formula-
tion, apply in sufficient water for
thorough coverage.
ITBCCFA Armyworm 0.5-1 Ib/A Foliar application (broadcast). May
ITBCBOA Corn earworm (4 Ib/gal EC) be applied by aircraft. Apply when
ITBCABA Cutworms field counts indicate damaging pest
ILAAABA Mites populations are developing or
present.
ITBMBOA Lesser cornstalk 1-2 lb/A Foliar application as a directed
borer (4 Ib/gal EC) spray (band). Apply in a 8 to 10
inch band to the base of the plants.
1.125-2.25 oz Prepegging soil application (band)
/l.OOO ft to irrigated peanuts. Apply in a
row 10 to 18 inch band over the fruit-
(152 G) ing zone just prior to pegging.
Incorporate into the top 1 to 2
inches of soil, plant size permit-
ting. Irrigate within 24 hours
after treatment using a minimum of
2 acre inches of water.
IHAMBMA Southern corn root- 1.125-2.25 oz Soil application at or just prior to
wom /1,000 ft pegging (band). Apply in a 10 to 18
row inch band over the fruiting zone.
(15% G) Incorporate granules into the top 1
to 2 inches of soil with a cultiva-
tor.
Issued: 10-29-81 III-059101-12
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EPA Index to Pesticide Chemicals
/04003AA
Site and Pest
Pear
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.05 ppm
Dormant or delayed dormant applica-
tion through 0.5 pounds per acre.
Do not make more than 1 application
during the dormant or delayed dor-
mant periods. Do not allow meat or
dairy animals to graze in treated
orchards.
IIBCABA
IRAKBYA
/05005AA
/05006AA
ITBCABA
IRACCAA
IRAKBYA
Cutworms
San Jose scale
Peas
Cutworms
Mealy plum aphids
San Jose scale
0.25-0.5 lb/ Dormant or delayed dormant applica-
100 gal/A tion. Apply to the entire tree to
(4 Ib/gal EC) the point of runoff. Use the higher
rate for severe infestation. Tank
mix with oil.
See Cucumber cluster.
0.05 ppm (fresh prunes)
Dormant or delayed dormant applica-
tion through 0.5 pounds per acre.
Do not make more than 1 application
during dormant or delayed dormant
periods. Do not allow meat or dairy
animals to graze in treated
orchards.
0.25-0.5 lb/ Dormant or delayed dormant applica-
100 gal/A tion. Apply to the entire tree to
(4 Ib/gal EC) the point of runoff. Use the higher
rate for severe infestation. Tank
mix with oil.
/14014AA
IOACABA
Root maggots
See Plum cluster.
See Cucumber cluster.
0.5 oz/1,000
ft row
(15% G)
3 ppm
Banded soil application (at plant-
ing time) through 0.5 ounce per
1,000 feet of row not to exceed 2.75
pounds per acre. Do not make more
than 1 application during the grow-
ing season.
Soil application at planting (band).
Apply in the seed furrow.
Issued: 10-29-81
111-059101-13
-------
Site and Pest
Radish (continued)
/14015AA
Rutabagas
IOACABA
Root maggots
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.5 oz/1,000 Soil application at planting (band).
ft row Apply as a drench to the seed fur-
(4 Ib/gal EC) row. Apply in a minimum of 20 gal-
lons of drench per acre.
3 ppm
Banded soil application (at plant-
ing time) through 1.65 ounces per
1,000 feet of row not to exceed 2.25
pounds per acre. Do not make more
than 1 application during the grow-
ing season. Do not use the tops for
food or feed purposes.
0.81-1.61 oz/ Soil application at planting (band).
1,000 ft row Apply over the row in a 2 to 4 inch
(15% G) band ahead of the planter shoe or
in front of the press wheel to
achieve shallow incorporation.
0.8-1.65 oz/ Soil application at planting (band).
1,000 ft row Apply as a spray in a 2 to 4 inch
(4 Ib/gal EC) band over the row ahead of the
planter shoe or in front of the
press wheel to achieve shallow in-
corporation. Apply in a minimum of
20 gallons spray per acre.
Issued: 10-29-81
111-059101-14
-------
/28019AA
Site and Pest
Sorghum (grain)
IOAHAIA
Sorghum midge
/28023AA
Soybeans
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.75 ppm (sorghum grain)
1.5 ppm (sorghum, milling fractions)
1.5 ppm (sorghum, forage)
6 ppm (sorghum, fodder)
14 day pregrazing or preharvest in-
terval for forage, hay, or silage
through 0.25 pound per acre for
foliar application. Apply in suf-
ficient water for thorough coverage.
Do not treat sweet varieties of
sorghum.
0.25 Ib/A Foliar application. May be applied
(4 Ib/gal EC) by aircraft. Make the first appli-
cation when 30 to 50 percent of the
seed heads are in bloom and midge
adults are present. A second and
third treatment at 3 day intervals
may be needed, but do not exceed 3
applications. To avoid phytotoxi-
city, do not treat plants that are
under extreme heat and drought
stress.
0.1 ppm (vegetable seed)
1 ppm (soybeans)
8 ppm (soybean forage)
15 ppm (soybean straw)
Seed treatment through 1 ounce per
100 pounds of seed.
Do not mix the seeds and chlorpyro-
phos with bare hands.
Do not use treated seed for human
consumption, as feed for livestock
or poultry, or for oil purposes.
Refer to Cucumber cluster.
Issued: 10-29-81
111-059101-15
-------
EPA Index to Pesticide Chemicals
/28020AA
Site and Pest
Sugar Beets
ITBCABA
IOAXACC
Cutworms
Sugarbeet root mag-
got (larvae)
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.05 ppm ( sugar beet tops)
0.2 ppm (sugar beet roots)
1 ppm (sugar beet pulp, dried)
3 ppm (sugar beet molasses)
Banded soil application (at plant-
ing time or postemergent up to the
2 to 4 true leaf stage) through 1.35
ounces per 1,000 feet of row. Do
not make more than 1 application per
year.
0.975-1.35 oz Soil application at planting (band).
/14018AA
Sweet Potato
INAVAWA
INAMDOA
INAMDXA
Conoderus wirewonns
Sweetpotato beetle
Systena flea
beetles
71,000 ft Apply in a 5 to 7 inch band over the
row drill row. Apply ahead of the plan-
or ter shoe as the seed is drilled in
1.5-2 Ib/A the center of the band or apply be-
[22 inch hind the planter over the drilled
row] row. Incorporate the granules into
(15% G) the top 1 to 2 inches of soil.
Postemergent soil application (band)
up to 2 to 4 true leaf stage. Apply
a 5 to 7 inch band over the plants
and incorporate the granules into
the top 0.5 to 1 inch of soil using
cultivators.
0.1 ppm
Broadcast soil application (pre-
plant) through 2 pounds per acre.
Do not make more than 1 application
during the growing season.
2 Ib/A Preplant soil application (broad-
(15% G) cast). Incorporate into the top 4
(4 Ib/gal EC) to 6 inches of soil using disk cul-
tivators.
Issued: 10-29-81
111-059101-16
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Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Fonnulation(s)
LIVESTOCK AND POULTRY
/53001IA
(Livestock Intended for Slaughter)
Beef Cattle
ILAMAWA
Boophilus ticks
2 ppm (cattle fat)
2 ppm (cattle meat)
2 ppm (cattle meat byproducts)
14 day preslaughter interval through
1 fluid ounce of 23.7 percent emul-
sifiable concentrate formulation per
8 gallons of water for animal spray
treatment or 0.5 gallon of 23.7
percent emulsifiable concentrate
formulation per 300 to 500 gallons
of water for animal dip treatment
or 2 cubic centimeters of 3.8 pound
per gallon of liquid - ready to use
formulation for animal treatment.
Limit treatment to 6 applications
at 21 day intervals per season for
spray and dip treatments.
1 fl.oz 23.7% use limited to qualified state or
EC/8 gal federal personnel responsible for
[0.75-1 gal/ quarantine programs to control fever
animal] ticks.
(23.7% EC) Animal spray treatment. Treat thor-
oughly and saturate the hair. Spray
at 200 to 400 pounds per square inch
to assure good penetration.
0.5 gal 23.7% use limited to qualified state or
EC/300-500 federal personnel responsible for
gal quarantine programs to control fever
(23.7% EC) ticks.
Animal dip treatment. To prepare
for dip treatment, clean vat thor-
oughly before filling with water.
Measure water into vat, or measure
the vat before filling and calculate
the number of gallons of water need-
ed to fill it. Record the various
levels. After filling the vat with
water, add the lower concentrated
dosage (per 500 gallons of water).
Agitate the dip solution thoroughly
prior to each use to assure uniform
treatment. To replenish, use the
higher concentrated dosage (per 300
gallons of water). Between dipping,
Issued: 10-29-81
111-059101-17
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EPA Index to Pesticide Chemicals
Site and Pest
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Beef Cattle (continued)
IMBHAAA
IOAUADA
IMBAAAA
Chewing lice
Horn fly
Sucking lice
2 cc 3.8 lb/
gal RTU/100
lb animal
body weight
(3.8 Ib/gal
RTU)
if a loss of liquid is recorded by
evaporation, add water only to raise
to previous level. If flooding has
occurred between dippings, use the
higher concentrated dosage (per 300
gallons of water) for the excess
water that has run into the vat.
Maintain the dip solution as clean
as possible by cleaning the race and
draining the pens regularly. Imme-
diately prior to each dipping oper-
ation, agitate the dip solution
thoroughly, paying particular atten-
tion to the jump-in end. Use ade-
quate mixing equipment. Be sure
free access to drinking water is
available to animals prior to dip
treatment. Care should be taken
when dipping young calves to prevent
injury or drowning.
Animal treatment. Wearing rubber
gloves in a well ventilated area,
apply in one spot to the midline
area of the animal, just behind the
shoulder blades and neck junction.
Use the dosage for animals weighing
up to 800 pounds. For cattle weigh-
ing more than 800 pounds, use no
more than 16 cubic centimeters.
Due to the small amount of material
required, care must be taken to
apply the proper dosage. Do not
treat bulls over 8 months of age of
any breed; purebred continental or
exotic breeds such as Simmental,
Chianina, Charolais, or Gelbvieh;
dairy-breed cattle of any age; cows
within 21 days prior to or 14 days
after calving; veal calves; or beef
breed calves under 12 weeks of age.
Dairy, Erahaa, continental or exotic
breed cattle crossed with beef
breeds (British) may be treated.
Do not treat cattle for 10 days
before or after shipping, dehorning,
castration, or vaccination. Do not
brand animals with a hot iron while
Issued: 10-29-81
111-059101-18
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Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formalation(s)
Beef Cattle (continued)
treating. The solvent system is
combustible and could cause a seri-
ous burn to the animals. If rein-
festation occurs, animals may be
retreated according to the following
schedule:
(1) 45 days after initial treatment
with a 14 day withdrawal prior to
slaughter.
(2) 30 days after initial treatment
with a 21 day withdrawal prior to
s laughter.
Do not retreat animals within less
than 30 days. Label claims cattle
may be treated during any season of
the year and provides for control
of horn fly for up to 6 weeks.
AGRICULTURAL PREMISES AND EQUIPMENT
(Poultry Houses, Equipment and Yards)
/55008JA
Turkey Pen
ILAHAAA
Chigger mites
4 lb/100-150
gal/A
(25% WP)
0.5 ppm (turkey fat)
0.5 ppm (turkey meat)
0.5 ppm (turkey meat byproducts)
7 day preslaughter interval through
4 pounds per acre for premise soil
treatment.
Premise soil treatment. To prevent
turkeys from becoming infested, ap-
ply just before turkeys are trans-
ferred to pens. For turkeys already
infested, spray the soil in pens
thoroughly. Allow a minimum of 21
days for chigger mite lesions on the
turkey to heal before slaughtering.
Spray a 10 to 15 feet protected area
around the periphery of the treated
pens. Do not spray directly on
turkeys. Limit treatments to 2 soil
applications at intervals of not
less than 28 days. Avoid getting
the spray on feed or in waters.
Open feed should be covered during
spraying operations and water
troughs should be flushed out im-
Issued: 10-29-81
111-059101-19
-------
/56005JA
ISASAAA
IJBAAAA
ILAVABA
IVAAABA
IVAHAAA
IMDAAAA
IMNAAAA
IJCAAAA
IMPBACA
IIFAAEA
IKAAAAA
ILAAACA
/61000JA
ISASAAA
IVAAABA
IOAAAAA
ILAAABA
IOAMAAA
IKAAAAA
ILAAACA
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest
Turkey Pen (continued)
Dosages and Tolerance, Use, Limitations
Formulation(s)
mediately after the spraying opera-
tions.
(Animal Buildings. Equipment and Outdoor Areas For Other Than Dairy.
Poultry and Pets)
Horse Stables
Ants
Centipedes
Clover mite
Cockroaches
Crickets
Earwigs
Fleas
Millipedes
Silverfish
Sowbugs
Spiders
Ticks (including
brown dog tick and
lone star tick)
1 ppm (horse, fat)
1 ppm (horse, meat)
1 ppm (horse, meat byproducts)
Premise treatment only.
Do not apply directly on horses.
Do not contaminate horse food or
feed items
0.5X solution Premise treatment. Spot applica-
[1 gal 0.5% tion. When possible, spray directly
on pests to reduce infestation.
Apply as a coarse spray or with a
paint brush into hiding places.
Apply spray until area is wet, but
not to the point of runoff. Repeat
as needed. For repeat applications,
dilute with equal parts of water.
For ant control, spray trails, nests
and points of entry. Spray directly
on ants where possible. For flea
and tick control, apply thoroughly
as a spot treatment to infested
areas such as horse beds and rest-
ing quarters where pests may be
present.
» - \^ —
solution/
1500 linear
feet]
(0.5% RTU)
(Farm Storage and Equipment (nonanimal))
Farm Buildings
Ants
Cockroaches
Flies
Mites
Mosquitoes
Spiders
Ticks
3.28 gal
0.86Z RTU/
1,000 sq.ft
(0.86% RTU)
Premise treatment. Apply as a final
coat of paint to walls, floors and
ceilings with brush or roller. May
also be sprayed. Allow to dry for
20 days before washing. The painted
surface should be washed with clear
water any time that it becomes
covered with dust or dirt in order
to reestablish maximum possible
contact between the treated surface
and pests.
Issued: 10-29-81
111-059101-20
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EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest
Dosages and Tolerance, Use, Limitations
Formulation(s)
(Empty Mushroom Houses and Greenhouses, Uncropped Mushroom House and
Greenhouse Soils)~
76100 60A
ISASBDA
Greenhouse Bench
Nursery Bench
Imported fire ants
0.4 oz/cu.yd
of media
(5% G)
Soil aplication. Use equipment
suitable to give uniform distribu-
tion of granules. Do not use plants
for food or feed purposes which have
been exposed to soil treated with
this formulation.
(Uncultivated and/or Uncropped Agricultural Areas (outdoor))
/40000AA
ISASBDA
Potting Media
Potting Soil
Imported fire ants
0.4 oz/cu.yd
of media
(5% G)
Soil aplication. Use equipment
suitable to give uniform distribu-
tion of granules. Do not use plants
for food or feed purposes which have
been exposed to soil treated with
this formulation.
/54007JA
/54003JA
[SASAAA
ELAMAQA
WNAAAA
HUMAN, PETS, AND OTHER ANIMALS
Dog Kennels
Pet Bedding
Pet Quarters
Ants
Brown dog tick
Fleas
0.4 oz/1,000
sq.f t
(0.5% G)
Old bedding of pets should be re-
moved and replaced with clean, fresh
bedding after treatment.
Premise treatment. Spot applica-
tion. For resting quarters, apply
to nearby cracks and crevices, along
and behind baseboards, window and
door frames and localized areas of
floor and floor covering where pests
may be present. Do not treat pets
with this formulation.
Issued: 10-29-81
111-059101-21
-------
EPA Index to Pesticide Chemicals
ISASAAA
IJBAAAA
ILAVABA
IVAAABA
IVAHAAA
IMDAAAA
IMNAAAA
IJCAAAA
IMPBACA
IIFAAEA
IKAAAAA
ILAAACA
Site and Pest
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Dog Kennels cluster (continued)
Ants
Centipedes
Clover mite
Cockroaches
Crickets
Earwigs
Fleas
Millipedes
Silverfish
Sowbugs
Spiders
Ticks (including
brown dog tick and
lone star tick)
0.5% emulsion
[1 gal 0.5%
solution/
1500 linear
feet]
(0.5% RTU)
Premise treatment. Spot applica-
tion. When possible, spray directly
on pests to reduce infestation.
Apply as a coarse spray or with a
paint brush to areas where pests are
normally found. Apply spray until
area is wet, but not to the point
of runoff. Repeat as needed. For
repeat applications, dilute with
equal parts of water. For ants,
apply to trails, nests and points
of entry. Spray directly on ants
where possible. For flea and tick
control, thoroughly apply as a spot
treatment to infested areas such as
bedding and sleeping area where
pests may be present. Do not treat
pets with this formulation. Do not
contaminate dog food and dog food
items.
ILAMAQA
IVAAABA
Brown dog tick
Cockroaches
16 fl.oz 20%
EC/5 gal
(20% EC)
Use limited to professional pest
control operators.
Premise treatment. Remove pets,
food and water utensils before
spraying. Thoroughly spray all
surfaces, cracks and crevices where
pests may hide or crawl. Allow
treated areas to dry before using
kennels.
Issued: 10-29-81
III-059101-22
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPY.RIFOS
Dosages and Tolerance, Use. Limitations
Formulation(s)
/54003IA
MHAAAA
Fleas
pump spray
(0.09-0.22%
PrL)
Animal treatment. Place dog on a
table or bench preferably outdoors.
Hold can in an upright position 3
to 6 inches from the dog and thor-
oughly spray all over the body
against the lay of the coat. Do not
spray on eyes or on scrotum. Spray
to leave the coat slightly damp down
to the skin level. Spraying time
should be between 30 to 60 seconds
on a medium sized dog. Label claims
1 treatment will protect against
reinfestation for up to 30 days.
Repeat as needed. Spray bedding and
sleeping area. Do not use on dogs
nursing puppies or on pups under 10
weeks old.
Issued: 10-29-81
111-059101-23
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
/35133AA
/35133DA
INAMAZA
/35049AA
INBQBEA
ORNAMENTALS
General Warnings and Limitations: Keep children and pets off treated
areas until spray has dried for spray formulations. Keep out of lawn and
garden fishponds and other bodies of water. Mosquitoes coming to rest on
areas treated for control of turf and ornamental plant pests will be kil-
led for varying periods of time after treatment, depending on exposure of
treated areas to weathering conditions. Outdoor application of formula-
tions greater than 10 percent active ingredient is limited to professional
pest control operators.
(Ornamental Plants (herbaceous, woody shrubs, trees and vines))
General Warnings and Limitations: Do not apply to azalea, camellia,
poinsettia, rose, or variegated ivy as injury may occur. Apply with
suitable hand or power spray equipment. Apply to both upper and lower
leaf surfaces and infested limb and trunk areas. Attempt to penetrate
dense foliage but avoid spraying to the point of excessive runoff.
Apply when pest first appears and repeat at 7 to 10 day intervals, if
needed.
Cottonwood (including nursery
stock)
Cottonwood leaf
beetle
Elm
Native elm bark
beetle
0.125-0.1875 Foliar application. Apply to
Ib/A .cottonwoods grown in nurseries and
[8-20 gal/A] plantations when field counts indi-
(4 Ib/gal EC) cate damaging beetle populations
are developing or present.
0.52 emulsion Foliar and bark application. To
(1-4 Ib/gal prevent adult beetles from over-
EC)
wintering in uninfected trees and
to reduce pest population in disease
free areas, apply to bottom 9 feet
of trunk. Wet thoroughly, but do
not apply to the point of runoff.
Care should be taken to apply the
spray to the base of the root flare.
Apply with back pack mist blower or
a hydraulic pressure sprayer from
spring through to early fall. To
reduce twig and branch feeding on
uninfected, high value trees; apply
to crown of tree in spring or early
summer using a sprayer that will
provide thorough coverage.
Issued: 10-29-81
111-059101-24
-------
/35006AA
/32005AA
/31000AA
/35000AA
/34004AA
/34005AA
IACAAA
ITBKABA
ITAUAEA
ITABAIA
1VABAAA
ILAAABA
ITBNASA
IRAEAAA
ISABAAA
1TBDADA
ITBCABA
IRAFAAA
IRAWAAA
IIADACA
ITBDAIA
MCAAAA
/35000AA
/34004AA
ITBQAOA
ITBQAEA
IRAHARG
IRAKBRG
ITBQANA
IRAKAZG
IRAKBUG
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Ornamental Deciduous Trees
Ornamental Evergreens
Ornamental Herbaceous Plants
Ornamental and/or Shade Trees
Ornamental Woody Shrubs
Ornamental Woody Vines
Aphids
Bagworm
Eastern tent cater-
pillar
Fall webworm
Grasshoppers
Mites
Orangestriped oak-
worm
Spittlebugs
Whiteflies
Yellownecked cater-
pillar
0.04 oz**/gal Foliar application.
(0.156 lb/
gal EC)
or
0.25 lb/
100 gal
or
0.04 oz/gal
(0.33-4 lb/
gal EC)
(2.35-41.2%
EC)***
Cutworms 0.5 lb/
Leafhoppers 100 gal
Mealybugs or
Mimosa webworm 0.08 oz/gal
Redhumped caterpil- (0.33-4 lb/
lar gal EC)
Thrips (2.35-41.2%
EC)***
(Ornamental and/or Shade Trees)
(Ornamental Woody Shrubs)
Foliar application.
Dogwood borer
Lilac borer
Oak lecanium
(crawlers)
Pine needle scale
(crawlers)
Rhododendron borer
Tea scale
(crawlers)
White peach scale
(crawlers)
1 lb/100 gal
or
0.01 Ib/gal
(0.156-4
Ib/gal EC)
(6.6-22.4%
EC)***
Bark application. Apply as a
coarse, low pressure spray. For
dogwood borer, apply to trunk and
lower limbs of trees when the adults
begin to emerge. Consult your State
Agricultural Extension Service for
proper timing of application in your
area.
Issued: 10-29-81
111-059101-25
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
/32000DA
ISASBDA
Ornamental Plants (nursery stock)
Imported fire ants
/35098AA
INBQAOA
Pine
Southern pine
beetle
0.01 lb/
10 gal
(0.156 lb/
gal EC)
or
0.125 lb/
100 gal
(2-4 Ib/gal
EC)
Dip treatment to nursery stock. For
control of pest in soil attached to
the roots of potted, containerized,
balled, or burlapped nursery stock;
completely submerge the ball of soil
in a tank containing the emulsion.
Do not remove burlap wrap or plastic
containers with drain holes prior to
submersion. Keep soil submerged un-
til complete saturation has oc-
curred, normally about 30 seconds.
Wear rubber gloves, boots, and apron
during operation.
8.4 lb/ Bark application. For preventative
100 gal treatment, apply to the main trunk
or of pines in the early spring or when
0.084 Ib/gal threat of attack exists from nearby
(2 Ib/gal EC) infested trees. Repeat as needed.
For remedial treatment, apply to the
main trunk of infested trees (or to
infested logs) when, damage occurs
but before adults begin to emerge.
/35102AA
ITBQAHA
Prunus
Peachtree borer
3 lb/100 gal
or
0.03 Ib/gal
(0.156-4
Ib/gal EC)
Bark application. Apply as a
coarse, low pressure spray to trunk
before newly hatched larvae enter
the trees. Thoroughly wet all bark
areas from ground level to scaffold
limbs. Consult your State Agricul-
tural Extension Service for proper
timing of application in your area.
Issued: 10-29-81
111-059101-26
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
(Lawns and Turf (including ground covers))
General Warnings and Limitations: Keep children and pets off treated
areas until the chlorpyrifos has been washed into the soil and the grass
is dry for granular formulations. Do not graze treated areas. Do not
apply within 7 days before or after seeding bluegrass. Apply granular
formulations using any hand or power operated gravity or rotary type
spreader. Labelling suggests that half the required dosage be applied
in one direction, the remainder applied at a right angle. Immediately
after application, thoroughly water to wash the chlorpyrifos into the
turf using 130 to 150 gallons of water per 5,000 square feet. Do not
mow for 24 hours following treatment. Apply emulsifiable concentrate
formulations as a coarse (large droplet) spray using a low pressure
sprayer such as a knapsack type, hose attached applicator, or other
similar equipment. Lawn should be moist at time of application and
mowed. Complete and uniform coverage of infested areas is necessary for
effective control, do not spot treat. Thoroughly water after applica-
tion to wash chlorpyrifos into the turf. For sod webworms, delay water-
ing or mowing treated area for 12 to 24 hours after treatment. Apply
when pest first appears and repeat as needed, unless otherwise speci-
fied. Do not apply to Dichondra.
Issued: 10-29-81 111-059101-27
-------
/33007AA
/33010AA
/33008AA
/670020A
ISASAAA
LTBCCFA
INASDUA
IQALAEA
ILAVABA
IVAHAAA
ITBCABA
IMDAAAA
IOBNABC
INAMADA
IVABAAA
IRAFAAA
ITBMABA
IIFAAEA
IRAEAAA
I NASHYA
Site and Pest
Golf Course Turf
Lawns
Ornamental Turf
Ants
Armyworm (including
fall armyworm)
Billbugs
Chinch bug
Clover mite
Crickets (including
field crickets and
mole crickets)
Cutworms
Earwigs
European crane fly
(larvae)
Flea beetles (in-
cluding dichondra
flea beetle)
Grasshoppers
Leafhoppers
Sod webworms
Sowbugs
Spittlebugs
Turf grass weevils
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
0.08-0.175
lb/5,000
sq.f t
(0.075-2.5%
G)
or
0.118 lb/
94.7-113.6
gal/5,000
sq. ft
(0.156 lb/
gal EC)
or
0.09-0.117 lb
/150 gal/
5,000 sq.ft
(0.33-4 lb/
gal EC)
(2.2-41.2%
EC)***
INASDYA
Bluegrass billbug
Application to established lawns and
turf. For chinch bug, apply when
activity or damage appears (yellow-
ing then browning of localized areas
often developing into spots, then
spreading through the lawn) usually
mid-June for first brood and mid-
August for second brood. Feeding
continues until mid-October when
temperatures cool. In northeastern
states, apply in May or June when
pest first appear. Repeat as need-
ed, usually in July or August. Con-
sult your State Agricultural Exten-
sion Service for proper timing of
application in your area. As a
preventative for chinch bug, apply
as soon as daily temperatures reach
80 F (26.7 C) and repeat at 60 day
intervals. For sod webworm, apply
in late April or early May when pest
first appears and repeat as needed,
usually at 30 to 45 day intervals.
Apply early or late in the day when
pest is active. For European crane
fly, consult your local State Agri-
cultural Extension Service for prop-
er timing of application in your
area.
0.23-0.47 lb/ Application to established lawns and
5,000 sq.ft turf. Apply early in the season
(4 Ib/gal EC) when pest first appears and repeat
as needed.
Issued: 10-29-81
III-059101-28
-------
EPA Index to Pesticide Chemicals
Site and Pest
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
FormulationC s)
Golf Course Turf cluster (continued)
1HBPAGC
IHBPAZC
European chafer
(larvae)
Japanese beetle
(larvae)
IASADC
WASBYA
Fiery skipper
(larvae)
Hyperodes weevils
ITBMCZA
Tropical sod web-
worm
0.23-0.5 lb/
5,000 sq.ft
(0.3-2.5% G)
or
0.23-0.47 lb/
150 gal/
5,000 sq.ft
(0.33-4 lb/
gal EC)
(5.3-41.2%
EC)***
Application to established lawns and
turf. Apply when larvae are young
and actively feeding near the soil
surface, usually during late July
or August or when 2 to 4 larvae per
square foot of soil are present.
Consult your State Agricultural
Extension Service for proper timing
of application in your area.
2.5 pt 5.3% Use limited to CA and HI.
EC/150 gal/ Application to established lawns and
5,000 sq.ft turf. Chinch bug erradication pro-
(5.3% EC) gram will control this pest.
Application to established lawns and
turf. Apply to suspected problem
areas in mid-April and repeat in
mid-May. Consult your State Agri-
cultural Extension Service for pro-
per timing of application in your
area.
0.23-0.25 lb/
5,000 sq.ft
(0.46-2.5% G)
or
0.23-0.25 lb/
150 gal/
5,000 sq.ft
(0.156-4 lb
/gal EC)
(2.35-41.2%
EC)***
0.156 lb/ Use limited to HI.
5,000 sq.ft Application to established lawns and
(4 Ib/gal EC) turf.
or
2.5 pt 5.3%
EC/150 gal/
5,000 sq.ft
(5.3% EC)
Issued: 10-29-81
111-059101-29
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest
Dosages and Tolerance, Use, Limitations
Formulation(s)
/670000A
/670000A
ILAWAAA
ILAAACA
FOREST, CHAPARRAL, NONAGRICULTURAL AND WASTELANDS
Noncrop Areas (including Camp
Sites, Paths, Picnic Areas, Recre- Prohibit public use during applica-
ational Areas, Roadsides, and tion and until spray has dried. Do
Trails) not apply where runoff into streams,
Uncultivated Nonagricultural Areas lakes or other bodies of water will
occur.
Chigger mites
Ticks
0.4-0.464 oz/ Outdoor treatment. Apply where
5,000 sq.ft pests are a nuisance or are a pos-
[4.69-11.48 sible public health problem. Treat
gal/5,000 low underbrush, grassy areas, weeds,
sq.ft] ground surface, and debris.
or
0.22-0.25
Ib/A
[40-100
gal/A]
(0.33-4 lb/
gal EC)
(41.2% EC)***
IOAMAAJ
Mosquitoes (adults) 0.025-0.05
Ib/A
(0.33-4 lb/
gal EC)
Outdoor treatment. Dilute with
water or oil. Use the low dosage in
light to medium vegetative cover.
Use the high dosage in medium to
(41.2% EC)*** heavy vegetative cover or for faster
knockdown and longer residual con-
trol in open areas and those with
light to medium vegetative cover.
12 lb/98 gal
solvent
or
maximum
0.03 Ib/A
(6 Ib/gal
SC/L)
Use limited to public health offi-
cials and trained personnel of mos-
quito abatement districts and other
public mosquito control programs.
Outdoor treatment. Thermal fog ap-
plication. Dilute with number 2
fuel oil or other fuel, diesel or
kerosene type oil suitable for in-
secticide and fogging use. Refer
to label instructions for proper
calibration of equipment.
Issued: 10-29-81
111-059101-30
-------
EPA Index to Pesticide Chemicals
Site and Pest
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Noncrop Areas cluster (continued)
0.005-0.01
Ib/A
(6 Ib/gal
SC/L)
Use limited to public health offi-
cials and trained personnel of mos-
quito abatement districts and other
public mosquito control programs.
Outdoor treatment. Ultra low volume
nonthermal (cold fog) application.
Apply by any standard ultra low vol-
ume ground applicator capable of
producing a nonthermal aerosol spray
with droplets ranging in size from 5
to 30 microns and a mass median di-
ameter of 10 to 15 microns. Refer
to label for proper calibration in-
structions of equipment. Observe
precaution while spraying as spray
droplets may permanently damage
automobile paint.
/300590A
Pine (including Southern Pines)
ISASBRA
INASCVA
Pales weevil
Pitch-eating weevil [6 gal/A]
Use limited to professional pest
control operators or personnel re-
sponsible for insect control pro-
grams in forest lands.
Seedling treatment. Apply immedi-
ately after transplanting. Treat
(4 Ib/gal EC) each seedling with enough spray to
thoroughly wet the foliage and stems
to the point of runoff.
2% emulsion
IHBQAOA
Southern pine
beetle
1% emulsion Bark and foliar application. Apply
(4 Ib/gal EC) to individual trees to the point of
runoff. For preventative treatment,
apply to the main trunk, in the early
spring or when threat of attacks ex-
ists from nearby infested areas.
Repeat as needed for continued pro-
tection. For remedial treatment,
apply to the main trunk of infested
trees (or to infested logs) when
damage occurs but before adult
beetles begin to emerge.
Issued: 10-29-81
111-059101-31
-------
Site and Pest
/670020A Recreational Areas
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Refer to ORNAMENTALS, (Lawns and Turf (including
ground covers), Golf Course Turf cluster for con-
trol of lawn and turf pests.
/65000MB
/65038MB
/65038MB
/65034MB
/65033MB
/65033MB
IOAMACC
NONCROP AQUATIC AREAS
General Warnings and Limitations: For use by trained personnel in public
health organizations, mosquito abatement districts, public mosquito con-
trol programs and professional pest control operators only. Do not apply
to water containing valuable crustaceans and fish. Consult your State
Fish and Game Department before using this product.
Aquatic Areas
Flooded Areas (including Flooded
Noncrop Areas)
Intermittently Flooded Areas (in-
cluding Culverts, Open Street
Catchbasins, Rain Barrels, Hollow
Stumps, Temporary Rain Pools, Tree
Holes, Woodland Pools)
Log Ponds
Stagnant Hater
Standing Hater
Mosquitoes (larvae) 0.025-0.05
Ib/A
(1-2% G)
(12 P/T)
Flooded area treatment. May be ap-
plied by aircraft. Apply uniformly
over flood water when mosquito lar-
vae are present.
Issued: 10-29-81
111-059101-32
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Aquatic Areas cluster (continued)
1.5 ppm Flooded area treatment. Apply uni-
(10.6% Heap) fonnly over flood water when mosqui-
to larvae are present. The rate i^
based on the total volume of water
to be treated. To determined the
volume of water present, measure the
length, width and average depth of
the impoundment (in feet) and calcu-
late the cubic feet of water. Con-
vert the calculated value to gallons
by multiplying by 7.48. Labeling
claims release of chlorpyrifos at a
rate that will provide control of
early instar larvae for one mosquito
breeding season. Retreat previously
treated areas only when control is
no longer evident as indicated by
the presence of third and fourth in-
star larvae.
0.1 Ib/A Prehatch treatment. Apply uniformly
(1% G) over known breeding areas prior to
flooding.
1.5 ppm Prehatch treatment. Apply uniformly
(10.6% Mcap) over known breeding areas prior to
flooding. The rate is based on the
total volume of water to be treated.
To determined the volume of water
presentj measure the length, width
and average depth of the impoundment
(in feet) and calculate the cubic
feet of water. Convert the calcu-
lated value to gallons by multiply-
ing by 7..48. Labeling claims re-
lease of chlorpyrifos at a rate that
will provide control of early instar
larvae for one mosquito breeding
season. Retreat previously treated
areas only when control is no longer
evident as indicated by the presence
of third and fourth instar larvae.
Issued: 10-29-81 111-059101-33
-------
EPA Index to Pesticide Chemicals
Site and Pest
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Aquatic Areas cluster (continued)
0.0125-0.025 Water related surface treatment.
Ib/A May be applied by aricraft. Dilute
(0.33-4 lb/ with water, kerosene, or fuel oil.
gal EC) Use in open areas or those with
(41.2% EC)*** light to mediumm vegetative cover.
0.025-0.5 Water related surface treatment.
Ib/A May be applied by aircraft. Dilute
(0.33-4 lb/ with water, kerosene, or fuel oil.
gal EC) Use in areas with medium to heavy
(41.2% EC)*** vegetative cover. Also may be used
for faster results and longer resid-
ual control in open areas or those
with light to medium vegetative cov-
er. Under such conditions, this
dosage should be used only where
there are no fish or crustaceans or
where their loss or loss of lower
components of the food chain would
not be significant.
/65038MB
IOAMAAC
Catch Basins
Mosquitoes (larvae) 0.25%
emulsion
[0.5 pt/
Water related surface treatment.
Apply as a coarse, low pressure
spray. • Uniformly cover the exposed
catch basin] walls (sides) of the basin and the
(4 Ib/gal EC) water surface.
/65026MA
/65026MA
IOAMAAC
Cesspools
Septic Tanks
Mosquitoes (larvae) 2.5 oz/5,000 Water treatment. Apply directly or
cu.ft water flush the required amount down
(4 Ib/gal EC) toilet.
Issued: 10-29-81
111-059101-34
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest
Dosages and Tolerance, Use, Limitations
FormulationC s)
165034MB Industrial Waste Water Impoundments
/65026MB Sewage Systems (including Sewage
Ponds and Waste Disposal Ponds and
Lagoons)
IMMAAC Mosquitoes (larvae) 0.5 oz/5,000
cu.ft water
or
4.35.oz/A ft
water
or
1 ppm
(4 Ib/gal EC)
Water related surface treatment.
Pour the required dosage into the
inflowing water or apply to the
water surface as a coarse, low pres-
sure spray. Treat stagnant water by
diluting with sufficient water or
oil to obtain uniform distribution.
1630010A
/740000A
iSASAAA
MHDACA
MAEA
IQMJACA
ISASAFA
ISBKABA
3BAAAA
IUVABA
IMGAHA
IViAABA
IVAHAAA
HABAEA
DfflAAAA
IIAMDAA
DIASEKA
UOAAA
»BACA
RtUEA
XAAAAA
ILAAACA
ITBMBEA
DOMESTIC DWELLINGS, MEDICAL FACILITIES AND SCHOOLS
General Warnings and Limitations: Do not allow children or pets to con-
tact treated surfaces until spray has dried. Remove pets and cover fish
tanks and bowls before spraying. Do not replace dishes and food until
spray has dried or eat any food that has been contaminated by spray.
Thoroughly wash dishes and food handling utensils with soap and water if
they become contaiminated by spray. In hospitals, remove patients prior
to treatment. Ventilate rooms for 2 hours before returning patients.
Domestic Dwellings (Indoor)
Hospitals (Indoor, Inedible)
Ants
Booklouse
Branbugs
Boxelder bug
Carpenter ants
Carpenter bee
Centipedes
Clover mite
Cluster fly
Cockroaches
Crickets
Drugstore beetle
Earwigs
Elm leaf beetle
Grain weevils
Millipedes
Silverfish
Sowbugs
Spiders
Ticks
Tobacco moth
Indoor treatment. Apply with injec-
(0.5% PrL) tion tube into cracks and crevices
where pests may be present. Place
injector tip 0.5 inch into areas to
be treated, releasing approximately
1 second spray per spot. For light
infestations or as preventive treat-
ment apply .at 3 foot intervals, for
heavy infestations apply at 1 foot
intervals if possible. For carpen-
ter ants and carpenter bee, locate
source of infestation and inject 5
to 10 seconds spray into tunnels and
cavities of pests. For carpenter
bee, seal entrance openings with
small pieces of stainless steel wool
after application. Whenever pos-
sible, spray directly on pests and
repeat as needed.
Issued: 10-29-81
111-059101-35
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest
Dosages and Tolerance, Use, Limitations
Formulation(s)
ISASAAA
INATAFA
ISBAAAA
ILAVABA
IVAAABA
IVAHAAA
IMDAAAA
IMPBABA
IMNAAAA
IJCAAAA
INARAGA
IMPBACA
IIFAAEA
IKAAAAA
Domestic Dwellings (Indoor) cluster (continued)
Ants
Carpet beetles
Centipedes
Clover mite
Cockroaches
Crickets
Earwigs
Firebrat
Fleas
Millipedes
Sawtoothed grain
beetle
Silverfish
Sowbugs
Spiders
0.25-0.5% Indoor treatment. Apply emulsifi-
emulsion able concentrate and liquid-ready to
(0.5-4 Ib/gal use formulations as a coarse spray
EC) or with a paint brush to areas where
(6-41.2% EC) pests are normally found. Apply
or spray until area is wet, but not to
0.5% emulsion the point of runoff. Repeat as
(0.5% RTU) needed. For ants, apply to trails,
(0.5% PrL) around doors and windows, and wher-
ever else pest may find entrance.
For carpet beetles, apply 0.5 per-
cent emulsion along baseboards and
edges of carpeting; in cracks and
crevices; under carpeting, rugs, and
furniture; in closets and on shelv-
ing; and wherever else pest is ob-
served or presence suspected. For
clover mite or heavy infestations of
other pests, use a 0.5 percent emul-
sion. For cockroaches, a period of
4 to 7 days is normally required for
maximum control. For spiders, apply
directly to pests wherever possible.
Also apply to localized areas where
infestations occur, particularly
around windows, doors, baseboards,
and crawl spaces. For quick knock-
down and/or flushing, tank mix with
2,2-dichlorovinyl dimethyl phosphate
or pyrethrins.
Issued: 10-29-81
111-059101-36
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest Dosages and Tolerance, Use, Limitations
Fonnulation(s)
Domestic Dwellings (Indoor) cluster (continued)
0.293 oz/ Indoor treatment. Before treating
1,000 sq.ft kitchen areas, remove all food,
(0.073 lb/ utensils, and other containers from
gal RTU) cabinets or other storage areas.
or With a 3 to 4 inch applicator
0.583 oz/ (brush, roller, or hand sponge),
1,000 sq.ft paint bands completely around the
(0.146 lb/ undersides of all shelving, never on
gal RTU) the shelves where food may contact
the treated surface. Remove all
cabinet and vanity drawers and band
3 exterior sides of each. Do not
apply to drawer interior or to front
panel. Paint a band completely
around the undersides of the counter
top and side panels of cabinets.
Pay special attention to treating
under and around the sink. Band
cabinet exteriors where they join
the wall or at point of cracks and
crevices. Paint a band around the
cabinet base and baseboards of the
entire home or facility, the flat
surface around each door casing, and
under shelving in closets and stor-
age areas. Treat bathroom vanities
in the same manner as kitchen cabi-
nets. Interior window casings may
be treated. Where quick knockdown
and/or flushing action is desired, a
pyrethrin spray may be used in hard
to reach areas. May be applied as a
coarse, low pressure spray (20
pounds per square inch) in 6 to 8
inch bands in attics and spider
nesting areas of interior metal or
wood framing of buildings. Avoid
spraying to the point of runoff.
Issued: 10-29-81 111-059101-37
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLDRPYRIFOS
Dosages and Tolerance,'Use, Limitations
Foimulation(s)
ISASAAA
IVAAABA
IQAAAAA
ILAAABA
IOAMAAA
IKAAAAA
ILAAACA
ILAMAQA
IMNAAAA
ILAMACA
IVAAABA
Domestic Dwellings (Indoor) cluster (continued)
Ants
Cockroaches
Flies
Mites
Mosquitoes
Spiders
Ticks
Brown dog tick
Fleas
Lone star tick
Cockroaches (in-
cluding American
cockroach and
German cockroach)
3.28 gal
0.86Z RTU/
1,000 sq.ft
(0.86Z RTU)
0.5Z emulsion
(1-4 Ib/gal
EC)
(6-41.2Z EC)
(0.5Z RTU)
or
(0.05Z RTU)
(0.09-0.5Z
PrL)
bait
[4-6 baits/
100 sq.ft]
(0.5Z Impr)
Indoor treatment. Apply as a final
coat of paint to walls, floors, and
ceilings with brush or roller. May
also be sprayed. Allow to dry for
20 days before washing. The painted
surface should be washed with clear
water anytime that it becomes cov-
ered with dust or dirt in order to
reestablish maximum possible contact
between the treated surface and
pests.
Indoor treatment. Apply as a spot
application to infested areas such
as pet beds and resting quarters,
nearby cracks and crevices, along
and behind baseboards, window and
door frames, and localized areas of
floor and floor coverings where
pests may be present. Old bedding
of pets should be removed and re-
placed with clean, fresh bedding
after treatment. Do not treat pets
with this chlorpyrifos formulation.
Indoor treatment. Use prepackaged
bait stations or apply bait in tea-
spoon amounts in a suitable bait
station or on paper, foil, paper-
board, or other material that will
permit removal. Locate stations
where pests have been observed. Re-
placement of baits should be made at
28 to 42 day intervals as needed.
If German cockroach is the main tar-
get species, place bait stations at
more frequent intervals in areas
where pest has been observed.
Issued: 10-29-81
111-059101-38
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Domestic Dwellings (Indoor) cluster (continued)
;?AAABA
(Cockroaches (in-
cluding American
cockroach and
German cockroach))
strips Indoor treatment for light infesta-
[up to 36 tions. Apply strips in all loca-
strips/100 tions applicable to the area being
sq.ft] treated, paying particular atten-
(10% Impr) tion to areas where pests may hide
or through which they may enter
premise. Replace strips when effec-
tiveness is diminished. If infesta-
tion persists, use a supplemental
conventional treatment. Label
claims effectiveness of 180 days.
6300 30A
Domestic Dwellings (Outdoor)
ISiSAAA
Ants
Keep children and pets off treated
areas until the chlorpyrifos has
been washed into the soil and the
grass is dry for granular formula-
tions or until spray has dried for
spray formulations. Keep out of
lawn and garden fishponds and other
bodies of water. Application for
formulations greater than 10 percent
active ingredient limited to profes-
sional pest control operators.
0.0007 lb/ Outdoor treatment. Apply lightly in
100 sq.ft and around nests, along runways, and
(0.12 D) other places where ants congregate.
Repeat at a minimum of 3 day inter-
vals as needed.
Outdoor treatment. Sprinkle the dry
(0.5% G) material on driveways, sidewalks,
and patios. D.o not water in.
0.003 lb/ Outdoor treatment. Apply directly
100 sq.ft from canister over ant hills, along
(0.5% G) flower bed borders, and in rock gar-
dens. Water into pest hiding areas
and repeat as needed.
Issued: 10-29-81
111-059101-39
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Fonnulation(s)
Domestic Dwellings (Outdoor) (continued)
ISASAAA
ILAWAAA
ILAVABA
IVAAABA
IVAHAAA
IMDAAAA
IMNAAAA
IJCAAAA
IOAMAAA
IIFAAEA
ILAAACA
Ants
Chigger mites
Clover mite
Cockroaches
Crickets
Earwigs
Fleas
Millipedes
Mosquitoes
Sowbugs
Ticks (including
brown dog tick)
0.08-0.13 lb/ Outdoor treatment. Control of pests
5,000 sq.ft is a result of a lawn pest control
(0.075-2.5Z program. If brown dog tick is a
G) particular problem, pay special at-
or tention to pet resting areas.
0.118 lb/
5,000 sq.ft
[94.7-113.6
gal/5,000
sq.ft]
(0.156 lb/
gal EC)
or
0.09-0.117
lb/5,000
sq.ft
[150 gal/
5,000 sq.ft]
(0.33-4 lb/
gal EC)
(2.35-41.2Z
EC)***
0.08-0.13 lb/
5,000 sq.ft
(0.5-2.32Z G)
or
0.118 lb/
5,000 sq.ft
[94.7-113.6
gal/5,000
sq.ft]
(0.156 lb/
gal EC)
or
0.09-0.117
lb/5,000
sq.ft
or
0.078-0.25
lb/100 gal
(0.45-4 lb/
gal EC)
(2.35-41.2Z
EC)***
or
0.5Z emulsion
(0.5Z RTU)
Outdoor treatment. To help prevent
infestation of buildings, apply as a
band 5 to 10 feet wide around and
adjacent to buildings where pests
are active and may find entrance and
water into soil for granular formu-
lations. Treat a band of soil 6 to
10 feet wide around and adjacent to
the building and also the building
foundation to a height of 2 to 3
feet where pests are active and may
find entrance for spray formula-
tions. Apply as a coarse spray to
thoroughly and uniformly wet the
band area. For liquid-ready to use
formulation, apply to the building
foundation to a height of 2 to 3
feet.
Issued: 10-29-81
111-059101-40
-------
EPA Index to Pesticide Chemicals
ISASAAA
ITAHAAA
MDAAAA
ILAAACA
ISASAAA
ILAHAAA
HAVABA
IVAAABA
1VAHAAA
MDAAAA
IWAAAA
IOAAAAA
IV4BAAA
IJCAAAA
IOAMAAA
IHMABA
IIFAAEA
IWAAAA
HAAACA
IS4SAAA
IVAHAAA
MPBABA
IAAAAA
ISASAAA
IUMAQA
MVABA
IHAAAA
UCAAAA
IIFAAEA
SAAAAA
Site and Pest
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Domestic Dwellings (Outdoor) (continued)
Ants
Crickets
Earwigs
Ticks
Ants
Chigger mites
Clover mite
Cockroaches
Crickets
Earwigs
Fleas
Flies
Grasshoppers
Millipedes
Mosquitoes
Sod webworms
Sowbugs
Spiders
Ticks (including
brown dog tick)
Ants
Crickets
Firebrat
Spiders
Ants
Brown dog tick
Clover mite
Cockroaches
Crickets
Earwigs
Fleas
Millipedes
Sowbugs
Spiders
0.005-0.008 Outdoor treatment. Apply as a band
lb/25 run- or barrier 12 to 18 inches wide
ning ft around dwelling.
(0.5-0.8% G)
0.0025-0.004 Outdoor treatment. Apply in areas
lb/100 sq.ft of heavy infestation or suspected
(0.5-0.8% G) harborages near buildings, tree
trunks, shrubs, and outbuildings
using a spreader.
0.5% emulsion Outdoor treatment. Apply as a re-
(0.5-4 Ib/gal sidual spray or with a paint brush
EC) to outside surfaces of buildings in-
cluding porches, screens, window
frames, eaves, patios, garages, re-
fuse dumps, and other areas where
pests congregate or have been ob-
served. Repeat as needed. Do not
apply to or allow spray to contact
ornamental plants.
0.2925 oz/
1,000 sq.ft
(0.073 lb/
gal RTU)
or
0.583 oz/
1,000 sq.ft
(0.146 lb/
gal RTU)
Outdoor treatment. Apply to exte-
rior window casings and thresholds
and porch borders. Also apply
around building foundations, roof
overhang, support pillars, roof gab-
les, and spider nesting areas of
exterior metal or wood framing of
buildings.
0.05% Outdoor treatment. Apply thoroughly
emulsion to localized infestation in outdoor
(0.05% RTU) areas where there are weeds or brush
or non-crop areas. For fleas and
0.5Z emulsion ticks, apply in and around kennels,
(0.5Z RTU) animal runs, or under porches where
or pets may rest. For ants, thoroughly
— wet hills and runways. Repeat as
(0.5% PrL) needed.
Issued: 10-29-81
111-059101-41
-------
ISASAAA
IVAAABA
ICAAAAA
ILAAABA
IOAMAAA
IKAAAAA
ILAAACA
ISASAFA
ISBKABA
IOAAAAA
ISBIADA
IOAMAAA
ITAAABA
ISAAADA
ISASBDA
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Domestic Dwellings (Outdoor) (continued)
Ants
Cockroaches
Flies
Mites
Mosquitoes
Spiders
Ticks
Carpenter ants
Carpenter bee
(Flies)
(Hornets)
(Mosquitoes)
(Moths)
(Wasps)
3.28 gal
0.86? RTU/
1,000 sq.ft
(0.86% RTU)
(0.5% PrL)
Outdoor treatment. Apply as a final
coat of paint to exterior surfaces
of buildings with brush or roller.
Allow to dry for 20 days before
washing. The painted surface should
be washed with clear water anytime
that it becomes covered with dust or
dirt in order to reestablish maximum
possible contact between the treated
surface and pests.
Outdoor treatment. Locate source of
infestation and inject 5 to 10 sec-
ond spray into tunnels and cavities
of pests.
0.5% emulsion Outdoor treatment. For reducing an-
(0.5% RTU) noyance from these pests. Apply to
or outside surfaces of screens, door
and window frames, or wherever pests
(0.5Z PrL) may find entrance. Also apply under
eaves, to dark corners, surfaces
around light fixtures on porches, in
garages, and other places where
pests alight or congregate. Repeat
as needed.
Imported fire ants
0.008 Ib/gal
11 gal/
moundj .
Outdoor treatment. Apply using a
sprinkler can. Thoroughly wet mound
and surrounding area to a 4 foot di-
TO.5-4 Ib/gal/ ameter (12.5 square feet). Apply
EC) .. •"' during cool weather when tempera-
T5T3-6.7Z tures range 65 to 80 F (18.3 to
EC)*** 26.7 C) or in early morning or late
evening. Apply to mounds as they
appear and do not disturb the mound
prior to treatment. If possible,
treat all mounds in the vicinity and
treat all colonies which may not as
yet have constructed a mound. .
Issued: 10-29-81
111-059101-42
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
URBAN AND RURAL INDOOR/OUTDOOR AREAS (PUBLIC HEALTH)
(680020A
Residential Areas
IOAM&AJ
Mosquitoes (adults) 12 lb/98 gal
solvent
or
maximum
0.03 Ib/A
(6 Ib/gal
SC/L)
0.005-0.01
Ib/A
(6 Ib/gal
SC/L)
Use limited to public health offi-
cials and trained personnel of mos-
quito abatement districts and other
public mosquito control programs.
Outdoor treatment. Thermal fog ap-
plication. Dilute with number 2
fuel oil diesel or kerosene. Refer
to label instructions for proper
calibration of equipment.
Outdoor treatment. Ultra low volume
nonthermal (cold fog) application.
Apply droplets ranging in size from
5 to 30 microns and a mass median
diameter of 10 to 15 microns. Refer
to label for proper calibration in-
structions of equipment. Observe
precaution while spraying as spray
droplets may permanently damage
automobile paint.
STRUCTURES. WOOD PRODUCTS AND WOOD COMMODITIY PROTECTION
(Terrestrial Structures (structural pest control and wood protection))
'54000NA
WOOONB
Terrestrial Structures
Use limited to professional pest
control operators. This formula-
tion of chlorpyrifos is designed for
treatment of soil to establish a
barrier which is lethal to termites.
Chlorpyrifos must be adequately dis-
persed in the soil to provide a bar-
rier between the wood in the struc-
ture and the termite colonies in the
soil or to control termites living
in the structure.
It is necessary for the effective
use of chlorpyrifos that the service
technician be familiar with current
control practices including trench-
ing, rodding, subslab injection, and
low pressure spray application.
Issued: 10-29-81
111-059101-43
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Terrestrial Structures (continued)
These techniques must be correctly
employed to prevent or control in-
festations by subterranean termite
species of Reticulitermes and Copto-
termes. Choice of appropriate pro-
cedures includes consideration of
such variable factors as the design
of the structure, water table, soil
type, soil compaction, grade condi-
tions, and domestic water supplies,
location and type. The biology and
behavior of the involved termite
species are important factors to be
known as well as suspected location
of the colony and severity of the
infestation within the structure to
be protected. For advice concerning
current control practices for speci-
fic local conditions, consult re-
sources in structural pest control.
Annual inspections of the treated
area should be made. Re treatment
may be necessary if there is an ac-
tive infestation or if there has
been a disruption of the chemical
barrier in the soil due to construc-
tion, excavations, landscaping, etc.
Soil should not be treated when
excessively wet. The termites'
source of moisture should be elimi-
nated by providing a chemical bar-
rier and/or repairing faulty con-
struction. Contamination of public
and private water supplies must be
avoided by following these precau-
tions: Use antiback-flow equipment
or procedures to prevent syphonage
of pesticide back into water sup-
plies. Do not treat soil that is
water saturated or frozen. Consult
state and local specifications for
recommended distances of treatment
areas froa veils, and refer to
Federal Housing Administration
(F.H.A.) Specifications for further
guidance. All nonessential wood and
cellulose containing materials, in-
cluding scrap wood and form boards,
Issued: 10-29-81 111-059101-44
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Terrestrial Structures (continued)
MEDAGA
Subterranean ter-
mites (including
Coptotermis and
Reticulitermes
spp)
should be removed from around foun-
dation walls, crawl spaces, and
porches.
1% emulsion Soil contact wood protection treat-
(4 Ib/gal EC) ment.
PRECONSTRUCTION SUBTERRANEAN TERMITE
TREATMENT
Effective preconstruction subterra-
nean termite control requires the
establishment of an unbroken verti-
cal and/or horizontal chemical bar-
rier between wood in the structure
and the termite colonies in the
soil. To meet F.H.A. termite proof-
ing requirements, follow the latest
edition of the Housing and Urban De-
velopment (H.U.D.) Minimum Property
Standards. After grading is com-
pleted and prior to the pouring of
the slab, slab supported/constructed
porches, or entrance platforms, make
the following treatments. Applica-
tions shall be made by a low pres-
sure spray for horizontal barriers
over areas intended for covering
floors, porches, and other critical
areas. Establish a vertical barrier
in areas such as around the base of
foundations, plumbing, back-filled
soil against foundation walls, and
other critical areas.
1. Where it is necessary to produce
a horizontal barrier, apply the
emulsion at the rate of 1 gallon
of 1 percent emulsion per 10
square feet to dirt fill. If
fill is washed gravel or other
coarse material, apply at 1.5
gallons of 1 percent emulsion
per 10 square feet. It is im-
portant that the emulsion
reaches the soil substrate.
a. If concrete slabs cannot be
poured over soil the same
day it has been treated, a
waterproof cover, such as
polyethylene sheeting,
Issued: 10-29-81
111-059101-45
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest Dosages and Tolerance. Use, Limitations
Formulation(s)
Terrestrial Structures (continued)
should be placed over the soil.
This is not necessary if foundation
walls have been installed around
the treated soil.
2. To produce a vertical barrier,
apply the emulsion at the rate
of 4 gallons of 1 percent emul-
sion per 10 linear feet per foot
of depth.
a. Rodding and/or trenching ap-
plications should not be
made below the top of the
footing.
b. Trench need not be wider
than 6 inches.
c. Rod holes should extend from
the base of the trench to
the top of the footing, and
should be spaced (about 1
foot) to provide a continu-
ous barier.
d. Emulsion should be mixed
with the soil as it is being
replaced in the trench.
Cover treated soil with a
layer of untreated soil.
3. Hollow block foundations or
voids of masonry shoud be
treated to make a continuous
chemical barrier in voids.
Apply at the rate of 2 gallons
of 1 percent emulsion per 10
linear feet so it will reach the
footing.
4. For crawl spaces apply at the
rate of 4 gallons of 1 percent
emulsion per 10 linear feet per
foot of depth from grade to bot-
tom of foundations. Application
may be made by rodding, low
pressure, spray, and/or trench-
ing. Treat both sides of foun-
dation and around all piers and
pipes.
a. Bod holes should be spaced
(about 1 foot) to provide a
continuous chemical barrier.
Issued: 10-29-81 III-059101-46
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Terrestrial Structures (continued)
b. Trench need not be wider
than 6 inches nor below the
foundation. The emulsion
should be mixed with the
soil as it is being replaced
in the trench. Cover the
treated soil with a layer of
untreated soil.
c. Do not apply chlorpyrifos in
any manner to an area in-
tended as a plenum air
space.
d. Do not apply chlorpyrifos as
an overall treatment to soil
in crawl spaces.
All holes drilled in construction
elements for treatment should be se-
curely plugged.
POSTCONSTRUCTION TREATMENTS
Postconstruction applications shall
be made by injection, rodding, low
pressure spray, and/or trenching.
Do not apply emulsion until location
of heat or air conditioning ducts,
vents, water and sewer lines, or
electrical conduits are known and
identified. Extreme caution must be
taken to avoid contamination of
these structural elements and air-
ways. Do not apply chlorpyrifos in
any manner to an area intended as a
plenum air space.
1. For slab-on-ground construction
apply at the rate of 4 gallons
of 1 percent emulsion per 10
linear feet. Application may be
made by sub-slab injection. In-
jectors should not extend beyond
the tops of the footings. Treat
along the outside of the founda-
tion and were necessary on the
inside of foundation walls.
Treatment may also be required
along 1 side of interior parti-
tions and along all cracks and
expansion joints.
a. Drill holes in the slab to
Issued: 10-29-81 111-059101-47
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Terrestrial Structures (continued)
provide a continuous chemi-
cal barrier.
b. Where necessary, drill
through the foundation walls
from the outside and force
the emulsion just beneath
the slab or along all the
cracks and expansion joints
and other critical areas.
c. For shallow foundations, 1
foot or less, dig a narrow
trench approximately 6 in-
ches wide along the outside
of the foundation walls. Do
not dig below the bottom of
the foundation. The emul-
sion should be applied to
the trench and the soil at
the rate of 4 gallons of 1
percent emulsion per 10
linear feet as the soil is
replaced in the trench.
Cover the treated soil with
a layer of untreated soil.
d. For foundations deeper than
1 foot follow rates for
basements.
Hollow block foundations or
voids of masonry should be
treated to make a continuous
chemical barrier in voids. Ap-
ply at the rate of 2 gallons of
1 percent emulsion per 10 linear
feet.
For basements apply at the rate
of 4 gallons of 1 percent emul-
sion per 10 linear feet. Where
footings are greater than 1 foot
of depth from the grade to the
bottom of the foundation, appli-
cation may be made by trenching
and/or rodding. Treat outside
of foundation vails, and if
necessary along inside of foun-
dation walls, along cracks in
basement floors, along interior
load bearing walls, around sewer
pipes, conduits, and piers.
Issued: 10-29-81 111-059101-48
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Terrestrial Structures (continued)
4. In crawl spaces apply at the
rate of 4 gallons of 1 percent
emulsion per 10 linear feet per
foot of depth from grade to bot-
tom of foundation. Application
may be made by rodding, and/or
trenching. Treat both sides of
foundation and around all piers
and pipes.
a. Rod holes should be spaced
(about 1 foot) to provide a
continuous chemical barrier.
b. Trench need not be wider
than 6 inches nor below the
foundations. The emulsion
should be mixed with the
soil as it replaced in the
trench. Cover the treated
soil with a layer of un-
treated soil.
c. Do not apply chlorpyrifos in
any manner to an area in-
tended as a plenum air
space. After treatment, se-
curely plug all holes dril-
led in construction ele-
ments.
d. Do not apply chlorpyrifos as
an overall treatment to soil
in crawl spaces.
All holes drilled in construction
elements for treatment should be se-
curely plugged.
m
Label claims it will provide residu-
al control of subterranean termites
for a minimum of 5 years when used
properly.
Wood boring beetles 1% emulsion Nonsoil wood protection treatment.
(including Anobii- (4 Ib/gal EC) For treatment of small areas, apply
dae, Cerambycidae,
and Lyctidae fami-
lies)
by brushing the emulsion evenly on
wood surfaces. For large or over-
head areas, apply as a coarse spray
to the point of runoff. Sprayed
surfaces should be avoided until
the spray has totally dried. Do
not apply in food serving areas
Issued: 10-29-81
111-059101-49
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYR1FOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Terrestrial Structures (continued)
while food is exposed. Do not use
in structures occupied by animals
to be used for food purposes or
which produce products for human
consumption. Do not use in food
areas of handling establishments,
restaurants or other areas where
food is commercially prepared or
processed.
V60150A
>ASAAA
/AAABA
/AHAAA
1PBABA
fPBACA
:AAAAA
GRAIN. BULK COMMODITIES. PROCESSED FOODS AND FOOD CONTAINERS
(Stored Raw Agricultural Food and Feed Commodities, Storage and Handling
Equipment)
Storage Bins (Empty)
Ants
Cockroaches
Crickets
Firebrat
Silverfish
Spiders
0.29 oz/
1,000 sq.ft
(0.073 lb/
gal RTU)
Paint band application. Before
treating, remove all food from stor-
age areas. Apply with a 3 to 4 inch
applicator, paint bands completely
around the undersides of all shelv-
ing, always under and never on the
shelves where food may contact the
treated surface. In case of severe
infestation, flush hard to reach
areas with a pyrethrin spray. Label
claims that insects contacting
treated areas, may live for several
hours but will die and prevent rein-
festation for 6 months.
Issued: 10-29-81
111-059101-50
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
I900JB
P900JB
(00 JB
IMOJB
iAA
WCA
MEA
ftc&
iFA
IKEA
m
SAA
SIA
4AAA
ttCA'
14EA
MAA
4CA
BEA
COMMERCIAL ESTABLISHMENTS
General Warnings and Limitations: Do not use chlorpyrifos in combination
with 2,2-dichlorovinyl dimethyl phosphate or pyrethrins for treatment of
food areas of food handling establishments. Use only deodorized kerosene
for oil based sprays in areas of food handling establishments.
(Commercial Establishments (edible product areas))
Commercial Transportation Facili-
ties (Indoor, Edible)
Eating Establishments (Indoor,
Edible) ~~~
Food Handling Establishments
(Indoor, EdibleT
Food Processing, Handling and Stor-
age Plants/Areas (Indoor, Edible)
Ants
Booklouse
Branbugs
Boxelder bug
Carpenter ants
Carpenter bee
Clover mite
Cluster fly
Cockroaches
Crickets
Drugstore beetle
Earwigs
Elm leaf beetle
Grain weevils
Millipedes
Silverfish
Sowbugs
Spiders
Ticks
Tobacco moth
Indoor treatment. Apply with injec-
(0.5Z PrL) tion tube into cracks and crevices
where pests may be present. Place
injector tip 0.5 inch into areas to
be treated, releasing approximately
1 second spray per spot. For light
infestations or as preventive treat-
ment apply at 3 foot intervals, for
heavy infestations apply at 1 foot
intervals if possible. For carpen-
ter ants and carpenter bee, locate
source of infestation and inject 5
to 10 seconds spray into tunnels and
cavities of pests. For carpenter
bee, seal entrance openings with
small pieces of stainless steel wool
after application. Whenever pos-
sible, spray directly on pests and
repeat as needed.
Issued: 10-29-81
111-059101-51
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest
Dosages and Tolerance, Use, Limitations
Formulat ion(s)
;ASAAA
AVABA
'AAABA
'AHAAA
[PBAEA
IPBACA
LAAAAA
1AAAFA
AAABA
Commercial Transportation Facilities (Indoor, Edible) cluster
(continued)
Ants
Clover mite
Cockroaches
Crickets
Firebrat
Silverfish
Spiders
Stored product in-
sects (including
branbugs, cigar-
ette beetle, con-
fused flour
beetle, Indian-
meal moth, Medi-
terranean flour
moth, red flour
beetle, rice
weevil, sawtoothed
grain beetle)
Cockroaches (in-
cluding American
cockroach and
German cockroach)
0.25-0.5%
emulsion
(0.33-4 lb/
gal EC)
(14.45-41.2Z
EC)
(0.073-0.146
Ib/gal RTU)
or
(0.5% RTU)
(0.5% PrL)
bait
[4-6 baits/
100 sq.ft]
(0.5% Impr)
Spot and/or crack and crevice treat-
ment. Spot treatment may encompass
crack and crevice treatment. Dilute
emulsifiable concentrate formulation
with water or deodorized kerosene.
For ants, apply to ant trails and
wherever these pests may find en-
trance. Repeat as needed but not
more than once every 7 days in res-
taurants and similar food service
establishments or more often than
once every 14 days in other types of
food handling establishments. In
case of emergency, chlorpyrifos may
be applied after 2 days from last
treatment but emergency use should
be limited to once per month.
Indoor treatment. Apply bait in
teaspoon amounts in a suitable bait
station or on paper, foil, paper-
board, or other material that will
permit removal. Locate stations
where pests have been observed. Re-
placement of baits should be made at
28 to 42 day intervals as needed.
If German cockroach is the main tar-
get species, place bait stations at
more frequent intervals in areas
where pest has been observed. When
applying bait where food is pre-
pared, processed, or served, main-
tain strict account of location and
number of bait stations. Do not ap-
ply bait until operations have
ceased for the day. Remove bait
stations before operations resume.
Issued: 10-29-81
III-059101-52
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Commercial Transportation Facilities (Indoor, Edible) cluster
(continued)
(Cockroaches (in- strips Indoor treatment for light infesta-
cluding American [up to 36 tions. Apply strips in all loca-
cockroach and strips/100 tions applicable to the area being
German cockroach)) sq.ft] treated, paying particular atten-
(10% Impr) tion to areas where pests may hide
or through which they may enter
premise. Replace strips when effec-
tiveness is diminished. If infesta-
tion persists, use a supplemental
conventional treatment. Label
claims effectiveness of 180 days.
Issued: 10-29-81 111-059101-53
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
(Commercial Establishments (areas other than edible product))
'7000JC Commercial, Institutional, and In-
dustrial Areas (Indoor, InedibleT
'OOOOJC Commercial Transportation
Facilities
'2000JC Eating Establishments (Indoor,
InedibfeT
'3000JC Food or Grocery Marketing, Storage
"Hants/Areas (Indoor, Inedible)
'1000JC Food Processing, Handling and Stor-
age Plants/Areas (Indoor,
Inedible)
•.ASAAA
;ATAFA
BAAAA
AVABA
AHAAA
DAAAA
:PBABA
CAAAA
AMAAA
PBACA
FAAEA
AAAAA
SAAAFA
Ants
Carpet beetles
Centipedes
Clover mite
Crickets
Earwigs
Firebrat
Millipedes
Mosquitoes
Silverfish
Sowbugs
Spiders
Stored product-in-
sects (including
branbugs, cigar-
ette beetle, con-
fused flour
beetle, Indian-
meal moth, Medi-
terranean flour
moth, red flour
beetle, rice
weevil, sawtoothed
grain beetle)
0.25-0.52
emu1s io n
(0.33-4 lb/
gal EC)
(14.45-41.22
EC)
or
0.52 emulsion
(0.52 RTU)
(0.52 PrL)
Indoor treatment. Apply emulsifi-
able concentrate and liquid-ready to
use formulations as a coarse spray
or with a paint brush to areas where
pests are normally found. Apply
spray until area is wet, but not to
the point of runoff. Repeat as
needed. For ants, apply to trails,
around doors and windows, and wher-
ever else pest may find entrance.
For carpet beetles, apply 0.5 per-
cent emulsion along baseboards and
edges of carpeting; in cracks and
crevices; under carpeting, rugs, and
furniture; in closets and on shelv-
ing; and wherever else pest is ob-
served or presence suspected. For
clover mite or heavy infestations of
other pests, use a 0.5 percent emul-
sion. For cockroaches, a period of
4 to 7 days is normally required for
maximum control. For spiders, apply
directly to pest wherever possible.
Also apply to localized areas where
infestations occur, particularly
around windows, doors, baseboards,
and crawl spaces. For quick knock-
down and flushing, tank mix with
2,2-dichlorovinyl dimethyl phosphate
or pyrethrins.
Issued: 10-29-81
111-059101-54
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)~"
Commercial, Institutional, and Industrial Areas (indoor, Inedible)
cluster (continued)
0.293 oz/ Indoor treatment. Before treating
1,000 sq.ft kitchen areas, remove all food,
(0.073 lb/ utensils, and other containers from
gal RTU) cabinets or other storage areas.
°r With a 3 to 4 inch applicator
0.583 oz/ (brush, roller, or hand sponge),
1,000 sq.ft paint bands completely around the
(0.146 lb/ undersides of all shelving, never on
gal RTU) the shelves where food may contact
the treated surface. Remove all
cabinet and vanity drawers and band
3 exterior sides of each. Do not
apply to drawer interior or to front
panel. Paint a band completely
around the undersides of the counter
top and side panels of cabinets.
Pay special attention to treating
under and around the sink. Band
cabinet exteriors where they join
the wall or at point of cracks and
crevices. Paint a band around the
cabinet base and baseboards of the
entire home or facility, the flat
surface around each door casing, and
under shelving in closets and stor-
age areas. Treat bathroom vanities
in the same manner as kitchen cabi-
nets. Interior window casings may
be treated. Where quick knockdown
and/or flushing action is desired, a
pyrethrin spray may be used in hard
to reach areas. May be applied as a
coarse, low pressure spray (20
pounds per square inch) in 6 to 8
inch bands in attics and spider
nesting areas of interior metal or
wood framing of buildings. Avoid
spraying to the point of runoff.
Issued: 10-29-81 111-059101-55
-------
Site and Pest
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Dosages and Tolerance, Use, Limitations
Formulation(s)
Commercial, Institutional, and Industrial Areas (Indoor, Inedible)
cluster (continued)
3ASAAA
/AAABA
3AAAAA
1AAABA
3AMAAA
;AAAAA
JVAACA
Ants
Cockroaches
Flies
Mites
Mosquitoes
Spiders
Ticks
3.28 gal
0.86% RTU/
1,000 sq.ft
(0.86% RTU)
(0.073-0.146
Ib/gal RTU)
Indoor treatment. Apply as a final
coat of paint to walls, floors, and
ceilings with brush or roller. May
also be sprayed. Allow to dry for
20 days before washing. The painted
surface should be washed with clear
water anytime that it becomes cov-
ered with dust or dirt in order to
reestablish maximum possible contact
between the treated surface and
pests.
Indoor treatment. Apply a coarse,
low pressure (20 pounds per square
inch or less) spray in 6 to 8 inch
bands. Avoid spraying to the point
of runoff. Box cars, ship holds,
and warehouses should be banded at
the wall/floor joints and on floors
along aisles and around pallets and
other designated storage areas.
Test treat surfaces prior to treat-
ment.
Issued: 10-29-81
111-059101-56
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Site and Pest
Dosages and Tolerance, Use, Limitations
Formulation(s)
Commercial, Institutional and Industrial Areas (Indoor, Inedible)
cluster (continued)
liABA
Cockroaches (in-
cluding American
cockroach and
German cockroach)
bait
[4-6 baits/
100 sq.ft]
(0.5% Impr)
(Cockroaches (in-
cluding American
cockroach and
German cockroach))
strips
[up to 36
strips/100
sq.ft]
(10% Impr)
1020A
Telephone Pedestals (Buried)
Ants
0.15 oz/100
sq. ft
(0.52 G)
Indoor treatment. Use prepackaged
bait stations or apply bait in tea-
spoon amounts in a suitable bait
station or on paper, foil, paper-
board, or other material that will
permit removal. Locate stations
where pests have been observed.
Livestock pens may be treated but
bait stations must be placed in a
manner not accessible to animals.
Replacement of baits should be made
at 28 to 42 day intervals as needed.
If German cockroach is the main tar-
get species, place bait stations at
more frequent intervals in areas
where pest has been observed. Main-
tain strict account of location and
number of bait stations when apply-
ing bait where food is prepared,
processed, or served. Do not ap-
ply bait until operations have
ceased for the day. Remove bait
stations before operations resume.
Indoor treatment for light infesta-
tions. Apply strips in all loca-
tions applicable to the area being
treated, paying particular atten-
tion to areas where pests may hide
or through which they may enter
premise. Replace strips when effec-
tiveness is diminished. If infesta-
tion persists, use a supplemental
conventional treatment. Label
claims effectiveness of 180 days.
Apply inside area.
ules uniformly.
Distribute gran-
Issued: 10-29-81
111-059101-57
-------
EPA Index Co Pesticide Chemicals
CHLORPYRIFOS
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
AERIAL, MOTHPROOFING AND TANK MIX APPLICATIONS
301500 Aerial Application
WVAAAA
Refer to
AGRICULTURAL CROPS
Corn, Cotton, Peanuts, Sorghum
NONCROP AQUATIC AREAS
Aquatic Areas
)00300 Tank Mix
WUAAA
Refer to
AGRICULTURAL CROPS
Almond, Apple, Cotton, Nectarine,
Peach, Pear, Plum, Prune
DOMESTIC DWELLINGS, MEDICAL FACILITIES AND SCHOOLS
Domestic Dwellings (Indoor), Hospi-
tals (Indoor, Inedible)
GRAIN. BULK COMMODITIES, PROCESSED FOODS, AND FOOD
CONTAINERS
Tstored Raw Agricultural Food and Feed Commodi-
ties, Storage and Handling Equipment)
Storage Bins
COMMERCIAL ESTABLISHMENTS
"TCommercial Establishments (areas other than
edible product)) ".
Conmercial, Institutional and In-
dustrial Areas (Indoor, Inedible),
Commercial Transportation Facili-
ties, Eating Establishments (Indoor,
Inedible), Food or Grocery Market-
ing, Storage and Distribution Facil-
ities (Indoor, Inedible), Food Pro-
cessing, Handling and Storage
Plants/Areas (Indoor, Inedible)
Issued: 10-29-81 111-059101-58
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Listing of Registered Pesticide Products by Formulation
94Z technical chemical
chlorpyrifos (059101)
000464-00404
99% technical chemical
chlorpyrifos (059101)
000464-00558
0.5 Ib/gal formulation intermediate
chlorpyrifos (059101) plus petroleum distillate (063503)
020954-00016
2.7 Ib/gal formulation intermediate
chlorpyrifos (059101)plus xylene range aromatic solvent (086803)
000464-00559
4 Ib/gal formulation intermediate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
004887-00169 009782-00029
6 Ib/gal formulation intermediate
chlorpyrifos (059101)
000464-00381
chlorpyrifos (059101) plus xylene (086802)
000464-00358
chlorpyrifos (059101) plus xylene range aromatic solvent (086803)
000464-00567
0.33Z formulation intermediate
chlorpyrifos (059101)
000059-00179
1% formulation intermediate
chlorpyrifos (059101)
000464-00474
10Z formulation intermediate
chlorpyrifos (059101)
006720-00246
15Z formulation intermediate
chlorpyrifos (059101)
006720-00245
25% formulation intermediate
chlorpyrifos (059101)
000464-00468
Issued: 10-29-81 111-059101-59
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Listing of Registered Pesticide Products by Formulation (continued)
25% formulation intermediate (continued)
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
000432-00625
44.8% formulation intermediate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
006720-00195
502 formulation intermediate
chlorpyrifos (059101)
000464-00489
52.4Z formulation intermediate
chlorpyrifos (059101)
000464-00564
0.1Z dust
chlorpyrifos (059101)
002781-00016
25Z dust
chlorpyrifos (059101)
000464-00509
0.075Z granular
chlorpyrifos (059101)
000557-01858
0.14Z granular
chlorpyrifos (059101)
020954-00083
0.22 granular
chlorpyrifos (059101)
000557-01903
0.23Z granular
chlorpyrifos (059101)
000557-01855
0.3Z granular
chlorpyrifos (059101)
003286-00050
0.331 granular
chlorpyrifos (059101)
011684-00006
Issued: 10-29-81 111-059101-60
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Listing of Registered Pesticide Products by Formulation (continued)
0.4% granular
chlorpyrifos (059101)
007001-00269
Q.46% granular
chlorpyrifos (059101)
002290-00037 007001-00303
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
000572-00216* 000904-00199 001159-00179
*jacket currently unavailable for review
0.47% granular
chlorpyrifos (059101)
009198-00043
0.5% granular
chlorpyrifos (059101)
000004-00207 000016-00101
000192-00141
000557-01865
000802-00532
001029-00123
005967-00148
007401-00296
015887-00014
034911-00012
000299-00200
000769-00429
000829-00223
002393-00245
006720-00131 •
008612-00094
033955-00540
042761-00003
000070-00178
000407-00397
000769-00488
000869-00158
004887-00182
006720-00175
009782-00021
033955-00541
000148-01266
000464-00399
000769-00495
000961-00274
005298-00020
006754-00069
013283-00008
034704-00055
0.51% granular
chlorpyrifos (059101)
000557-01925
Q.52Z granular
chlorpyrifos (059101)
044312-00002
0.55% granular
chlorpyrifos (059101)
000538-00094 000538-00095
0.57% granular
chlorpyrifos (059101)
000961-00328
0.575Z granular
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
000572-00261
000538-00098
Issued: 10-29-81
111-059101-61
-------
EPA Index Co Pesticide Chemicals
CHLORPYRIFOS
Listing of Registered Pesticide Products by Formulation (continued)
0.6Z granular
chlorpyrifos (059101)
000961-00275
0.65Z granular
chlorpyrifos (059101)
044312-00004
0.7Z granular
chlorpyrifos (059101)
008780-00042
0.72Z granular
chlorpyrifos (059101)
000829-00222
Q.75Z granular
chlorpyrifos (059101)
008660-00010
0.8Z granular
chlorpyrifos (059101)
006720-00238
0.85Z granular
chlorpyrifos (059101)
000538-00153
0.92% granular
chlorpyrifos (059101)
000538-00154 008780-00034 009198-00031 009198-00032
044312-00003 044312-00005
1Z granular
chlorpyrifos (059101)
000070-00184 000148-01267 000279-02833 000464-00396
000769-00474 000904-00297 002393-00229 005481-00121
006720-00174 006720-00234 006720-00251 007001-00209
007401-00293 008329-00012 008590-00435 008590-00450
009782-00022 011682-00024 034682-00001
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
001769-00267
1.1-41 granular
chlorpyrifos (059101)
000961-00326 002169-00258 002169-00272
Issued: 10-29-81 111-059101-62
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Listing of Registered Pesticide Products by Formulation (continued)
1.16% granular
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
001159-00199
1.22 granular
chlorpyrifos (059101)
009198-00026
1.34% granular
chlorpyrifos (059101)
000538-00111
1.35% granular
chlorpyrifos (059101)
000538-00070
008590-00371
2Z granular
chlorpyrifos (059101)
000279-02985 000769-00475
2.22 granular
chlorpyrifos (059101)
000538-00069
2.3% granular
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
000004-00178
2.32% granular
chlorpyrifos (059101)
002290-00038 008590-00486
010404-00017
010404-00015 010404-00016
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
000904-00200 000961-00261 001159-00181
010711-00004
000572-00219
002169-00264
2.5% granular
chlorpyrifos (059101)
000299-00210 007001-00276
51 granular
chlorpyrifos (059101)
000464-00475 000464-00553
10% granular
chlorpyrifos (059101)
000454-00449
Issued: 10-29-81
009198-00039 034704-00054
111-059101-63
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Listing of Registered Pesticide Products by Formulation (continued)
151 granular
chlorpyrifos (059101)-
000464-00523
1Z p.
ch
elieted/tableted
lorpyrifos (059101)
008329-00010
2.32Z wettable powder
chlorpyrifos (059101)
033265-00003
25Z wettable powder
chlorpyrifos (059101)
000464-00446 000464-00501
50Z wettable powder
chlorpyrifos (059101)
000464-00547 008590-00264
10.61 microencapsulated
chlorpyrifos (059101)
000464-00517 008329-00013
0.5% impregnated materials
chlorpyrifos (059101)
004822-00153 006248-00017
10Z impregnated materials
chlorpyrifos (059101)
008730-00009 008730-00010
0.156 Ib/gal emulsifiable concentrate
chlorpyrifos (059101) plus xylene (086802)
000869-00149 043789-00063
0.33 Ib/gal emulsifiable concentrate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
001769-00281
0.45 Ib/gal emulsifiable concentrate
chlorpyrifos (059101) plus petroleum distillate (063503)
020954-00016
0.5 Ib/gal eaulsifiable concentrate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
001769-00282
Issued: 10-29-81 111-059101-64
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Listing of Registered Pesticide Products by Formulation (continued)
0.5 Ib/gal emulsifiable concentrate (continued)
chlorpyrifos (059101) plus petroleum distillate (063503)
000192-00142
chlorpyrifos (059101) plus xylene range aromatic solvent (086803)
000769-00486 033955-00547
0.667 Ib/gal emulsifiable concentrate
chlorpyrifos (059101) plus xylene range aromatic solvent (086803)
033955-00548
1 Ib/gal emulsifiable concentrate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
000299-00202 000550-00127 000572-00213 000904-00222
005481-00068 006720-00148
chlorpyrifos (059101) plus xylene (086802)
003590-00008
chlorpyrifos (059101) plus xylene range aromatic solvent (086803)
000769-00487 000869-00172 042761-00004
chlorpyrifos (059101), petroleum distillate (063503) plus xylene
(086802)
000602-00230
1.2 Ib/gal emulsifiable concentrate
chlorpyrifos (059101) plus petroleum distillate (063503)
000373-00096
2 Ib/gal emulsifiable concentrate
chlorpyrifos (059101)
000829-00226
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
000052-00239 000464-00343 000464-00412 000464-00447
000550-00138 000551-00190 000572-00286 000655-00466
000904-00234 000904-00235 000904-00294 000912-00074
001386-00570 003590-00006 004704-00016 004816-00593
006754-00037 007122-00068 007234-00041 009782-00020
011214-00004 011214-00017
chlorpyrifos (059101) plus heavy aromatic naphtha (006602)
002169-00233
chlorpyrifos (059101) plus petroleum distillate (063503)
001748-00098
Issued: 10-29-81 111-059101-65
-------
EPA Index Co Pesticide Chemicals
CHLORPYRIFOS
Listing of Registered Pesticide Products by Formulation (continued)
2 Ib/gal emulsifiable concentrate (continued)
chlorpyrifos (059101) plus xylene (086802)
000004-00200 000004-00212 000148-00892 000998-00072
000998-00073 038621-00005
chlorpyrifos (059101) plus xylene range aromatic solvent (086803)
000769-00485 008590-00394 008590-00395 034704-00065
chlorpyrifos (059101), aromatic petroleum derivative solvent (006501)
plus heavy aromatic naphtha (006602)
000070-00180
chlorpyrifos (059101), aromatic petroleum derivative solvent (006501)
plus xylene (086802)
006720-00059
4 Ib/gal emulsifiable concentrate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
000464-00368 000464-00448 000551-00191 000904-00295
001748-00097 006720-00206 007122-00059 009782-00028
chlorpyrifos (059101) plus xylene (086802)
000655-00499 000998-00071 003590-00007 005602-00058
007234-00040 038621-00006
chlorpyrifos (059101) plus xylene range aromatic solvent (086803)
000464-00360 000464-00464 000464-00524 000464-00562
002217-00646 008590-00556 034704-00066
chlorpyrifos (059101), heavy aromatic naphtha (006602) plus xylene range
aromatic solvent (086803)
002169-00267
0.511 emulsifiable concentrate
chlorpyrifos (059101) plus heavy aromatic naphtha (006602)
000557-01880
2.22 emulsifiable concentrate
chlorpyrifos (059101) plus petroleum distillate (063503)
000557-01888
2.352 emulsifiable concentrate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
006720-00237
2.85Z emulsifiable concentrate
chlorpyrifos (059101) plus petroleum distillate (063503)
000299-00172 043789-00065
Issued: 10-29-81 111-059101-66
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Listing of Registered Pesticide Products by Formulation (continued)
5.3Z emulsifiable concentrate
chlorpyrifos (059101), aromatic petroleum derivative solvent (006501)
plus petroleum distillate (063503)
000239-02423
5.42 emulsifiable concentrate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
006720-00257
5.65% emulsifiable concentrate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
010663-00024 010663-00025
6% emulsifiable concentrate
chlorpyrifos (059101)plus aromatic petroleum derivative solvent
(006501)
008845-00030 042057-00100
chlorpyrifos (059101), aromatic petroleum derivative solvent (006501)
plus xylene (086802)
002125-00068
6.6% emulsifiable concentrate
chlorpyrifos (059101) plus xylene (086802)
000869-00168
6.7Z emulsifiable concentrate
chlorpyrifos (059101) plus xylene range aromatic solvent (086803)
034911-00018
6.79% emulsifiable concentrate
chlorpyrifos (059101), aromatic petroleum derivative solvent (006501)
plus petroleum distillate (063503)
000802-00530
12.3% emulsifiable concentrate
chlorpyrifos (059101) plus xylene (086802)
000148-00891
14.45% emulsifiable concentrate
chlorpyrifos (059101) plus aromatic petroleum distillate (006601)
005602-00068
20% emulsifiable concentrate
chlorpyrifos (059101), aromatic petroleum derivative solvent (006501)
plus petroleum distillate (063503)
000327-00135
Issued: 10-29-81 111-059101-67
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Listing of Registered Pesticide Products by Formulation (continued)
22.4Z emulsifiable concentrate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
008780-00038
chlorpyrifos (059101) plus heavy aromatic naphtha (006602)
000655-00588
chlorpyrifos (059101) plus xylene range aromatic solvent (086803)
033955-00537
23.7Z emulsifiable concentrate
chlorpyrifos (059101)
000464-00450
24.9? emulsifiable concentrate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
000904-00240*
*jacket currently unavailable for review.
251 emulsifiable concentrate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
001159-00196
41.21 emulsifiable concentrate
chlorpyrifos (059101) plus aromatic petroleum derivative solvent
(006501)
004816-00594
6 Ib/gal soluble concentrate/liquid
chlorpyrifos (059101) plus xylene (086802)
000464-00428
0.073 Ib/gal liquid ready-to-use
chlorpyrifos (059101) plus petroleum distillate (063503)
026693-00001
0.146 Ib/gal liquid ready-to-use
chlorpyrifos (059101) plus petroleum distillate (063503)
026693-00002
3.8 Ib/gal liquid ready-to-use
chlorpyrifos (059101)
000410-00082 000464-00542
0.05Z liquid ready-to-use
chlorpyrifos (059101) plus xylene range aromatic solvent (086803)
004758-00135
Issued: 10-29-81 111-059101-68
-------
EPA Index to Pesticide Chemicals
CHLORPYRIFOS
Listing of Registered Pesticide Products by Formulation (continued)
0.25% liquid ready-to-use
chlorpyrifos (059101) plus xylene range aromatic solvent (086803)
004822-00176
0.5% liquid ready-to-use
chlorpyrifos (059101)
000432-00624 004822-00156
chlorpyrifos (059101) plus aromatic petroleum distillate (006601)
008845-00021 008845-00031 034911-00017 036272-00015
chlorpyrifos (059101) plus xylene range aromatic solvent (086803)
000239-02490 000299-00214 000464-00560 000475-00229
000478-00108 000654-00126 000769-00507 003696-00109
003696-00112 004822-00177 004981-00061 009367-00029
009688-00042 010370-00029 033955-00550 034704-00086
045385-00015
chlorpyrifos (059101), aromatic petroleum derivative solvent (006501)
plus petroleum distillate (063503)
000478-00092 000869-00167 005748-00067 043789-00061
0.86% liquid ready-to-use
chlorpyrifos (059101)
045600-00001
0.09% pressurized liquid
chlorpyrifos (059101)
000773-00053
0.22% pressurized liquid
chlorpyrifos (059101)
000464-00471 002382-00077 003134-00038 045078-00013
0.5% pressurized liquid
chlorpyrifos (059101)
000499-00147
chlorpyrifos (059101) plus petroleum distillate (063503)
000602-00284 004822-00152
chlorpyrifos (059101) plus xylene range aromatic solvent (086803)
000478-00110 009688-00044
chlorpyrifos (059101), petroleum distillate (063503) plus xylene range
aromatic solvent (086803)
004822-00179 009688-00046
Issued: 10-29-81 III-059101-69
-------
9999999
EPA Index Co Pesticide Chemicals
CHLORPYRIFOS
State Label Registrations
AZ Reg. No.
026693-03446
CA Reg. No.
000550-04776
007001-07731
011015-06997
FL Reg. No.
000539-09223
003122-07568
009782-03626
009782-10483
HI Reg. No.
035053-05218
MD Reg. No.
035278-04458
MI Reg. No.
031398-06602
NY Reg. No.
006665-09472
TX Reg. No.
000557-08277
000557-09760
000557-09764
000557-09768
000557-09772
000557-09776
000557-09780
000557-09784
015887-04982
000909-04674
008278-09129
000550-04775
006720-03366
009782-03627
026885-10146
000909-04699
008278-09272
000829-06767
009404-03472
009782-03628
034822-03138
037843-08564 037843-08565
031398-06603
000557-09757
000557-09761
000557-09765
000557-09769
000557-09773
000557-09777
000557-09781
010370-04457
034149-03545
000557-09758
000557-09762
000557-09766
000557-09770
000557-09774
000557-09778
000557-09782
012188-03130
034149-03546
005481-03838
010965-09885
002342-06963
009404-03488
009782-10405
000557-09759
000557-09763
000557-09767
000557-09771
000557-09775
000557-09779
000557-09783
013268-03139
Issued: 10-29-81
111-059101-70
-------
II. REQUIREMENT FOR SUBMISSION OF GENERIC DATA
A. This portion of the guidance document is a Notice
issued under the authority of FIFRA Section 3(c)(2)(B)
and describes, in table format, the data required
for maintaining the registrability of each product.
Additionally, a bibliography (Appendix II-l) is
included that identifies that data considered as
part of the data base supporting this standard. EPA
has determined that additional generic data described
in this Notice must be submitted to EPA for evaluation
in order to maintain in effect the registration(s)
of your product(s) identified as an attachment to
the cover letter accompanying this guidance document.
As required by FIFRA Section 3(c)(2)(B), you are
required to take appropriate steps to comply with
this Notice.
EPA may suspend the registration of each of those products
unless, within the specified time, you have informed EPA
how you will satisfy the requirements of this Notice.
Any such suspension will remain in effect until you have
complied with the terms of this Notice.
B. What Generic Data V Must Be Submitted. You may ascertain
which generic data you must submit by consulting Table A
at the end of this chapter. That table shows all the
generic data needed to evaluate the continued registrability
of all products, and the dates by which the data must be
submitted. The required data must be submitted and any
necessary studies must be conducted in accordance with
EPA-approved protocols, the Pesticide Registration
Guidelines 2/, or data collected under the approved
protocols of the Organization for Economic Cooperation
and Development (OECD). If you wish not to develop data
which are necessary to support the registration or
reregistration of certain uses appearing in your labeling,
you may delete those uses at the time you submit your
revised labeling.
Also for certain kinds of testing (generally ecological
effects), EPA requires the test substance to be a "typical
formulation," and in those cases EPA needs data of that
I/ Generic data pertain to the properties or effects of a
particular ingredient, and thus are relevant -to an evaluation of
the risks of all products containing that ingredient (or all such
products having a certain use pattern), regardless of any such
product's unique composition or use. Product-specific data relate
only to the properties or effects of a product with a particular
composition (or a group of products with closely similar composition)
2/ The Pesticide Registration Guidelines were reproposed on
November 24, 1982 in 47 Federal Register 53192.
34
-------
type for each major formulation category (e.g., emulsifiable
concentrates, wettable powders, granulars, etc.) These
are classified as generic data and when needed are
specified in Table A. EPA may possess data on certain
"typical formulations" but not others. Note; The "typical
formulation" data should not be confused with product-
specific data (Table B) which are required on each
formulation. Product-specific data are further explained
in Chapter IV of this document.
C. Options Available for Complying With Requirements
to Submit Data
Within 90 days of your receipt of this Notice you must
submit to EPA a completed copy of the form entitled "FIFRA
Section 3(c)(2)(B) Summary Sheet" [EPA Form 8580-1, Appendix
II-2] for each of your products. On that form you must
state which of the following methods you will use to comply
with the requirements of this Notice:
1. (a) Notify EPA that you will submit the data, and
(b) either submit the existing data you believe
will satisfy the requirement, or state that
you will generate the data by conducting
testing. If the test procedures you will
use deviate from (or are not specified in)
the Registration Guidelines or protocols
contained in the Reports of Expert Groups
to the Chemicals Group, Organization for
Economic Cooperation and Development (OECD)
Chemicals Testing Programme, you must enclose
the protocols you will use.
2. Notify EPA that you have entered into an agreement
with one or more other registrants to jointly
develop (or share in the cost of developing) the
data. If you elect this option, you must notify EPA
which registrant(s) are parties to the agreement.
3. File with EPA a completed "Certification of Attempt to
Enter Into an Agreement With Other Registrants for
Development of Data" (EPA Form 8580-6, Appendix II-3)V
4. Request that EPA amend your registration by deleting the
uses for which the data are needed. (This option is not
available to applicants for new products.)
*/ FIFRA Section 3(c)(2)(B) authorizes joint development of
data by two or more registrants, and provides a mechanism by
which parties can obtain an arbitrator's decision if they agree
to jointly develop data but fail to agree on all the terms of
the agreement. The statute does not compel any registrant to
agree to develop data jointly.
(Footnote continued at bottom of next page)
35
-------
5. Request voluntary cancellation of the registration(s)
of your products for which the data are needed. (This
option is not available to applicants for new products.)
D. Procedures for Requesting Changes in Testing Methodology
and Extensions of Time
EPA recognizes that you may disagree with our conclusions
regarding the appropriate ways to develop the required
data or how quickly the data must be submitted. If the
test procedures you plan to use deviate from (or are not
specified in) the registration guidelines or protocols
contained in the reports of the Expert Groups to the
Chemical Groups, Organization for Economic Cooperation
and Development (OECD) Chemicals Testing Programme, you
must submit the prot'ocol for Agency review prior to the
initiation of the test.
If you think that you will need more time to generate the
required data than is allowed by EPA's schedule, you may
submit a request for an extension of time. The extension
request must be submitted in writing to the Product
Manager. The extension request should state the reasons
why you conclude that an extension is appropriate. While
EPA considers your request, you must strive to meet the
deadline for submitting the required data.
(Footnote continued from previous page)
In EPA's opinion, joint data development by all registrants
who are subject to the requirements to submit a pertinent item
of data or a cost-sharing agreement among all such registrants
is clearly in the public interest. Duplication of testing could
increase costs, tie up testing facilities, and subject an unneces-
sarily large number of animals to testing.
As noted earlier, EPA has discretion not to suspend the
registration of a product when a registrant fails to submit data
required under FIFRA Section 3(c)(2)(B). EPA has concluded that
it is appropriate to exercise its discretion not to suspend in
ways which will discourage duplicative testing. Accordingly, if
(1) a registrant has informed us of its intent to develop and
submit data required by this Notice; and (2) a second regis-
trant informs EPA that it has made a bona fide offer to the
first registrant to share in the expenses of the testing [on
terms to be agreed upon or determined by arbitration under FIFRA
Section 3(c)(2)(B)(iii)]; and (3) the first registrant has declined
to agree to enter into a cost-sharing agreement, EPA will not
suspend the second firm's registration. While the first firm is
not required to agree to jointly develop data, EPA is not required
to force the second firm to engage in economically inefficient
duplicative testing in order to maintain its registration.
36
-------
III. REQUIREMENT FOR SUBMISSION OF PRODUCT-SPECIFIC DATA
Note: This Section applies only to manufacturing-use
products, not end-use products.
A necessary first step in determining which statements must
appear on your product's label is the completion and submission
to EPA of product-specific data* listed on the form entitled
"Product Specific Data Report" (EPA Form 8580-4, Appendix III-l)
to fill "gaps" identified by EPA concerning your product. Under
the authority of FIFRA Section 3(c)(2)(B), EPA has determined
that you must submit these data to EPA in order to register or
reregister your product(s). All of these data must be submitted
not later than six months after you receive this guidance document
"Product-Specific Data Requirements for Manufacturing-Use
Products" appearing in Table B permit you to determine which
product-specific data you must submit. This can be done by
examining the entries in the column of those tables entitled
"Must Data Be Submitted Under §3(c)(2)(B)."
*/ Product specific data pertains to data that support the
formulation which is marketed; it usually includes product chemistry
data and acute toxicology data.
37
-------
oracA RBOUIREMENT.-S BXJR CHUORPYRI txjs
§158.120 - PRODUCT CHEMISTRY
Guideline Citation and
Name of Test
Product Identity:
oJ. i identity UL inytcuicnus
61-2 - Statement of Composition
61-3 - Discussion of Formation of
Ingredients
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis
62-2 - Certification of Limits
62-3 - Analytical Methods for
Enforcement of Limits
Physical and Chemical Characteristics
63-2 - Color
/TO O r>Ht/c-i/^al Cf-af-fi
UJ j tTiySlCaJL bCaLfc:
63-4 - Odor
63-5 - Melting Point
DJ D noi-Ling iroini.
Test
Substancel
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
Guidelines
Status
R
R
R
CR
R
R
R
R
R
R
R
Are Data Footnote
Required 2,3 Number
Yes No
[X] M
IX] H
[X] [~]
[X] [~J
[X] [~]
[X] [~]
[xi n
[X] [~]
ixi n
[X] l~]
n ix]
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR CHLDRPYRIbUS
S158.120 - PRODUCT CHEMISTRY (Con't)
Guideline Citation and
Name of Test
Test Guidelines
Substance1 Status
Are Data Footnote
Required2,3 Number
Yes No
Physical and Chemical Characteristics
(Continuec
63- 7 -
63- 8 -
63- 9 -
63-10 -
63-11 -
63-12 -
£T_1 1 _
63-20 -
3)
Density, Bulk Density, or
Specific Gravity
Solubility
Vapor Pressure
Dissociation constant
Octanol/water partition
coefficient
pH
Stability
Corrosion Characteristics
TGAI R
TGAI or PAI R
PAI R
PAI R
PAI R
TGAI R
TGAI R
TGAI R
[X]
[X] [~]
[X] I"]
IX) M
[XI M
IX] [")
IX] l~]
[X] l~)
Other Requirements:
64- 1 - Submittal of samples
Choice
CR
I 1
[X]
1. Test Substance* TGAI = Technical grade of the active ingredient; PAI = Pure active ingredient; C = Either
substance.
2. If current data has been submitted to the Agency, the registrant should reference or resubnut it.
3. Data must be submitted by ytn KMT
^
-------
TABLE A
GENERIC DATA REQUIREMENTS TOR CHUORPYRIPOS
Data Requirements
Composition
Does EPA Have Data
To Satisty This
Requ i rement? (Yes,
No, or Partially)
Bibliographic
Citation t
Must Additional
Data Be Submitted
Under PIFRA Section
3(C)(2)(B)?2
§158.125 Residue Chemistry
171-4 - Nature of Residue (Metabolism)
- Plants
- Livestock
PAIRA
PAIRA and plant
Partially
Partially
171-4 - Residue Analytical Method
- Plant residues
TGAI and metabolites
Yes
0100001, 0100002
0100003, 0100004
0100005
0100006,
0100008,
0100010,
0100012,
0100014,
0100016,
0100018,
0100020,
0100022,
0100024
0100026,
0100029,
0100036,
0100038,
0100041,
0100043,
0100045,
0100047,
0100049,
0100051,
0100055
0100007
0100009
0100011
0100013
0100015
0100017
0100019
0100021
0100023
0100028
0100030
0100037
0100039
0100042
0100044
0100046
0100048
0100050
0100053
Yes3
Yes4
No-
t In all data tables, data citations with seven digits are preceeded by a "GS" in the bibliography.
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR CHLORPYRIFOS
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Sectio
Data Requirement Composition No, or Partially) Citation 3(c)(2)(B)?2
S158.125 Residue Chemistry
(continued)
171-4 - Residue Analytical Method
(continued)
- animal residues TGAI and metabolites Yes 0100025, 0100027
0100031, 0100032
0100033, 0100034
0100035, 0100040
0100052, 0100054
171-4 - Storage Stability Data PAI Yes 0100056, 0100057
0100058, 0100059
0100060, 0100061
0100062, 0100063
0100064, 0100065
0100066, 0100067
0100068, 0100069
0100070
No5
No
171-4 - Magnitude of the Residue -
Residue Studies (continued)
- Root and Tuber Vegetable Group TEP
Radishes TEP
Rutabagas TEP
Sugar Beets TEP
No
Yes
Yes
Yes
0100071, 0100072
0100073
0100074
0100075, 0100076
Yes6
No
NO
No
-------
GENERIC ElftTA REQUIREMENTS FOR CHLORPVRIFOS
Data Requirement
§158.125 Residue Chemistry
(continued)
171-4 - Magnitude of the Residue -
Residue Studies (continued)
Sweet Potatoes
Turnip (roots)
- Leaves of Root and Vegetable
Group
Sugar beet tops
Turnip greens
- Bulb Vegetables Group
Onions (dry bulb)
- Brass ica (Cole) Leafy
Vegetable Group
Broccoli
Brussels sprouts
Cabbage
Cabbage, Chinese
1
Composition
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Partially
Partially
No
Yes
Partially
No
Yes
No
Partially
Partially
Partially
Partially
Bibliographic
Citation
0100077
0100078, 0100079
0100080, 0100081
0100082, 0100083
0100081, 0100080
0100084
0100085
0100086
0100087
0100088
Must Additional
Data Be Submitted
Under FIFRA Sectioi
3(c)(2)(B)?2
Yes7
Yes8
Yes9
No
Yes9
YeslO
No
Yes11
Yes*2
Yesl2
Yesl3
Yesl4
-------
TABLE A
GENERIC DATA REQUIREMENTS TOR CHLORPYRI FOS
1
Data Requirement Composition
Si 58. 125 Residue Chemistry
(continued)
171-4 - Magnitude of the Residue -
Residue Studies (continued)
- Brass ica (Cole) Leafy
Vegetable Croup (continued)
Cauliflower TEP
- Legume Vegetables Group TEP
Cowpeas TEP
Dry beans (including black- TEP
eyed peas, kidney beans, and
navy beans)
Lentils TEP
Lima beans TEP
Peas TEP
Snap beans (including green, TEP
Does EPA Have Data
To Satisfy This
Requirement? (Yes, Bibliographic
No, or Partially) Citation
Partially 0100089
No
Yes 0100090
Partially 0100090
Partially 0100090
Partially 0100091
Partially 0100090
Partially 0100092
Must Additional
Data Be Submitted
Under FIFRA Sectioi
3(c)(2)(B)?2
YeslS
Yesl6
Nol7
Yesl7
Yesl7
Nol8
Yes I7
Yes'19
string, wax, and pole)
Soybeans
TEP
Partially
0100093
Yes20
-------
GENERIC DATA REQUIREMENTS FOR CHUORFYRX fOS
1
Data Requirement Composition
§158.125 Residue Chemistry
(continued)
171-4 - Magnitude of the Residue -
Residue Studies (continued)
- Foliage of the Legume TEP
Vegetable Group
Bean forage and hay TEP
Cowpea forage and hay TEP
Lentil forage and hay TEP
Lima bean forage and TEP
hay
Pea forage and hay TEP
Snap bean forage TEP
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
Requirement? (Yes, Bibliographic Under FIFRA Sectio
No, or Partially) Citation 3(c)(2)(B)?2
No Yes21
Partially 0100090 Yes22
Yes 0100090, 0100091, No23
0100092
Yes 0100090, 0100091, No2^
0100092
Yes 0100091 No24
Yes 0100090 No25
Yes 0100092 No24
and hay
Soybean forage, hay, TEP
and straw
Fruiting Vegetable (except TEP
cucurbits) Group
Peppers TEP
Partially
No
Partially
0100093
0100094
Yes27
Yes27
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHLORPYRIKJS
Data Requirement
S158.
171-4
125 Residue ^Chemistry
(continued!
- Magnitude of the Residue -
Residue Studies (continued)
- Fruiting Vegetables (except
cucurbits) Group (con't)
Tomatoes
- Cucurbit Vegetable Group
Cucumbers
Pumkins
- Citrus Fruits Group
Citrus Fruits
- Pone Fruits Group
Apples
Pears
- Stone Fruits Group
1
Composition
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Yes
No
Yes
Yes
Yes
Yes
No
Yes
Yes
No
Must Additional
Data Be Submitted
Bibliographic Under FIFRA Sectioi
Citation 3(c)(2)(B)?2
0100095 No
Yes28
0100096 No
0100097 No
No
0100098, 0100099 No
0100100
0100100, 0100090 No
0100101
0100100 No
Yes30
Cherries
TEP
Yes
0100102, 0100103
No
-------
JR£OC?LJX£%JSMCSN^r&3 EXJR ^HI-JOKE*
Data Requirement
§158.
171-4
125 Residue Chemistry
(continued)
- Magnitude of the Residue -
Residue Studies (continued)
- Stone Fruits Group (con't)
Nectarines
Peaches
Plums (fresh prunes)
- Small Fruits and Berries
Group
Cranberries
Grapes
Strawberries
- Tree Nut Group
Almonds
Walnuts
1
Composition
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
TEP
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
Yes
Yes
Yes
No
Partially
Yes
Partially
No
Yes
Yes
Bibliographic
Citation
0100104, 0100105
0100106
0100104, 0100105
U100106
0100107
0100108
0100109
0100110
0100102, 0100111
0100102, 0100112
Must Additional
Data Be Submitted
Under FIFRA Sectioi
3(c)(2)(B)?2
No
No
No
Yes31
Yes32
No
Yes33
Yes34
No
No
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHLURPYRIFOS
1
Data Requirement Composition
§158.125 Residue Chejnistry
(continued^
171-4 - Magnitude of the Residue -
Residue Studies (continued)
- Cereal Grains Group TEP
Corn (fresh and grain) TEP
Sorghum grain TEP
- Forage, Fodder^ and Straw TEP
of Cereal Grains Group
Corn forage and fodder TEP
Sorghum forage and fodder TEP
- Non-grass Animal Feeds TEP
Group
Alfalfa, green forage TEP
and hay
- Herbs and Spices Group TEP
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No, or Partially)
No
Yes
Partially
NO
Yes
Partially
NO
Partially
No
Must Additional
Data Be Submitted
Bibliographic Under FIFRA Sectioi
Citation 3(c)(2)(B)?2
Yes35
0100113, 0100114 No3^
0100115, 0100116
0100117, 0100118 Yes36
Yes37
0100113, 0100114 No
0100115
0100119 Yes38
Yes3*
0100120 Yes40
Yes41
Dill
TEP
Yes
0100090, 0100091
0100092
No42
-------
GENERIC DATA REQUIREMENTS FOR CHUORPYKXFOB
1
Data Requirement Composition
§158.125 Residue Chemistry
(continued)
171-4 - Magnitude of the Residue -
Residue Studies (continued)
- Miscellaneous Conmodities
Bananas TEP
Cottonseed TEP
Figs TEP
Kiwi Fruit TEP
Mint TEP
Okra TEP
Peanuts . TEP
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
Requirement? (Yes, Bibliographic Under FIFRA Sectio
No, or Partially) Citation 3(c)(2)(B)?2
Partially
Partially
Partially
Yes
Yes
No
Yes
0100121
0100122, 0100123
0100124
0100125
0100126
0100127
-
0100128,0100129
Yes43
Yes44
Yes4 5
No
No
Yes46
No
Sunflower seed
Tobacco
TEP
TEP
Yes
Yes
0100130,0100131
0100132
00030504
No
No
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR CHLORPYRIbXXS
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2
Data Requirement
Composition
Does EPA Have Data
To Satisfy This
Requ i rement ? (Yes,
No, or Partially)
Bibliographic
Citation
§158.125 Residue Chcraistry
(continued)
171-4 - Magnitude of the Residues
in Food-producing animals
Fat, meaty and meat by-
products pi: cattle, goats
is, horses, and sheep
Milk
TGAI or plant/animal
metabolites
Yes
TGAI or plant
metabolites
Yes
0100134,
0100136,
0100138,
0100140,
0100142,
0100144,
0100146,
0100135
0100137
0100139
0100141
0100143
0100145
0100147
0100148, 0100149
0100150, 0100151
Poultry and Eggs
TGAI or plant
metabolites
- Food Handling Establishments TEP
Yes
Yes
0100152, 0100153
0100154, 0100155
0100156, 0100157
0100158, 0100159
0100160, 0100161
0100162, 0100163
No
1. Composition: TGAI =* Technical grade of the active ingredient; PAIRA = Pure active ingredient, radiolabelled; TEP =
Typical end-use product; EP = End-use product.
2. Data must be submitted no later than
MAR
3. Studies must be submitted concerning the metabolism of ring-labeled [l4C]chlorpyrifos and metabolites, especially
TCP, by corn and a representative legume and root crop. Radioactive residues must be characterized by a method such
as GC or HPLC and verified by MS.
-------
GENERIC DATA REQUIREMENTS FOR CHLORP*RI FOS5
§158.125 Residue Chemistry
(continued)
4. Metabolism studies must be submitted utlizing ruminants and poultry. Residues of parent and metabolites, especially
TCP, must be characterized and quantified in muscle, fat, kidney, and liver of beef cattle 14 days after an animal
dip treatment with ring-labeled [14C] at a rate equivalent to 0.5 gal. of the 23.7% EC product/300 gal. of water.
Poultry must be dosed with ringlabeled [!4C]chlorpyrifos at 5.5 ppm in the diet for three days. Eggs must be
sampled twice daily throughout the dosing period. Animals must be sacrificed within 24 hours of the final dose and
residues characterized and quantified in eggs, muscle, fat, gizzard, heart, liver, and skin.
5. If the requested metabolism studies in plants and animals identify other metabolite residues of toxicological
concern, then additional methodology may be needed.
6. The crop group tolerance is not appropriate because data are required for two additional members of this crop
group (carrots and potatoes). The sweet potato tolerance (0.1 ppm) differs significantly (greater than a
factor of five) from tolerances covering other group members.
7. Additional data are required for residues in or on sweet potatoes 90 days following a single broadcast soil applica-
tion with either the 15% G or the 4 Ib/gal EC formulation at 2 Ib ai/A. These tests must be conducted in CA, LA,
and NC. Alternatively, the registrant may propose a 125-day PHI.
8. Additional data are required for residues in or on turnip roots reflecting a single at-plant soil application with
either the 15% G or 4 Ib/gal EC formulation at 2.25 Ib ai/A. Tests must be conducted in TX and GA. Residues in
or on turnip roots 30 days following a single directed spray to plant bases (immediately after transplanting) with
the 4 Ib/gal EC formulation at 2.25 Ib ai/A. Tests must be conducted in the sites listed above.
9. The crop group tolerance is not adequately supported because additional data are required for turnip greens.
Additional data are required for residues in or on turnip greens reflecting a single at-plant soil application with
either the 15% G or 4 Ib/gal EC formulation at 2.25 Ib ai/A. Tests must be conducted in TX and GA. Residues in
or on turnip greens 30 days following a single directed spray to plant bases (immediately after transplanting) with
the 4 Ib/gal EC formulation at 2.25 Ib ai/A. Tests must be conducted in the sites listed above.
10. This crop group tolerance is not adequately supported because residue data are required for one additional member
of the crop group (garlic, leek, or shallot).
11. This crop group tolerance is not adequately supported because residue data are required for one additional com-
modity (mustard greens). Data gaps exist for broccoli and cabbage.
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHLORPYRIFOS
§158.125 Residue Chemistry
(continued)
12. Additional residue data reflecting a single at-planting soil treatment using the 15% G or 4 Ib/gal EC at 1.38 oz
ai/1,000 feet of row with a 20-inch row spacing (2.25 Ib ai/A) are required. Tests must be conducted in CA.
Also residue data at 30 days post treatment reflecting a single application to the soil at transplanting employing
4 Ib/gal EC formulation at 1.38 02 ai/1,000 feet of row with a 20-inch row spacing (2.25 Ib ai/A) are needed.
Tests must be conducted in CA.
13. Additional residue data reflecting a single at-planting soil treatment using the 15% G or 4 Ib/gal EC at 1.38 oz
ai/1,000 feet of row are required. Tests must be conducted in NY, FL, TX, CA, and WI. Also residue data at 30
days post treatment reflecting a single application to the soil at transplanting employing the 4 Ib/gal EC formulation
at 1.38 oz ai/l»000 feet of row with a 20-inch row spacing (2.25 Ib ai/A) are needed. Tests must be conducted in
the sites listed above.
14. Additional residue data reflecting a single at-planting soil treatment using the 15% G or 4 Ib/gal EC at 1.38 oz
ai/1,000 feet of row are required. Tests must be conducted in CA, FL, HI, and NJ. Also residue data at 30 days
post treatment reflecting a single application to the soil at transplanting employing the 4 Ib/gal EC formulation at
1.38 oz ai/1,000 feet of row with a 20-inch row spacing (2.25 Ib ai/A). Tests must be conducted in the sites
listed above.
15. Additional residue data reflecting a single at-planting soil treatment using the 15% G formulation at 1.38 oz ai/1,000
feet of row with a 20-inch row spacing (2.25 Ib ai/A) or the 4 Ib/gal EC formulation at 1.2 oz ai/1,000 feet of row
(2 Ib ai/A with a 20-inch row spacing) are required. Tests must be conducted in CA and MI or NY and OR. Also res-
idue data at 30 days post treatment reflecting a single application to the soil at transplanting employing 4 Ib/gal
EC formulation at 1.2 oz ai/1,000 feet of row are needed. Tests must be conducted in the sites listed above.
16. This crop group tolerance is not adequately supported because residue data are required for snap beans and soy-
beans. Tolerances for residues in or on various members of this group differ by a factor of more than five.
The use pattern is much different for soybeans (seed treatment, at-planting, and foliar treatments) than for
other legumes (seed treatment only).
17. A separate tolerance of 0.1 ppm should be established for residues on these coninodities since the seed and pod
vegetable group, to which these crops were included, is now obsolete (FR 48:29855).
18. The present tolerance is not supported because residue data for lima bean cannery waste (a processed commodity)
were not submitted. However, similar data requested for snap beans can be translated to lima beans to satisfy
this data requirement.
-------
GENERIC DATA REQUIREMENTS FOR CHJJORPYRIFOH
§158.125 Residue Chemistry
(continued)
19. The following data are required: a. Residue data fron snap bean (pod plus seeds) samples taken at maturity
from plants raised from seed treated at 1 02 ai/100 Ib seed with one of the WP formulations in OR. b. Re-
sidue data concerning cannery residue, remaining after processing of snap bean pods having measurable,
weatherd residues as a result of being grown from treated seed. Exaggerated application rates may be required
to obtain residue values at or near the tolerance level.
20. Residue data from soybeans harvested 28 and 40 days following the last of six aerial and ground foliar applica-
tions of the 4 Ib/gal EC at 0.5 Ib ai/A which had been preceded by an at-planting or early postemergence applic-
tion of the 15% G at 1.3 Ib ai/A. The studies must be conducted in IL, MM, and MS.
21. This crop group tolerance is not adequately supported because residue data are required for field peas and the
data requirements for soybeans must be satisfied.
22. Residue data from dried hay, harvested at its normal time of maturity, from plants grown from seed treated at
1 oz ai/100 Ib seed with the 25 or 50% WP. The studies must take place in NY, OR, CA, WI, MI, and ND to
account for the major growing areas of all major legumes, since the data will be translated to hay for the
following crops: peas, lentils, cowpeas, snap beans, and lima beans.
23. Tolerances for cowpea hay and forage, and lentil hay and forage must be proposed, since they are raw agricultural
commodities of cowpeas and lentils. Alternatively, the petitioner could satisfy the requirements for a crop group
tolerance for the Foliage of Legume Vegetable Group. !
24. The tolerance for lima bean forage and snap bean forage must be revoked, since an identical tolerance exists for bean
forage.
25. The residue data requested for bean hay will be translated to pea hay and will be adequate to allow proposal of a
tolerance for pea hay.
26. Residue data from soybean forage and straw harvested 14 and 28 days respectively following the last of six 0.5
Ib ai/A foliar applications of the 4 Ib/gal EC using aerial and ground equipment must be obtained. Residues in or on
hay must also be determined. The studies must be conducted in IL, MM, MO, and AR. Residue data from soybean forage
and soybean straw, obtained at their normal maturity from plants treated at-planting with a soil application of the
15% G at 1.3 Ib ai/A must be obtained. The studies must be conducted in IL, MM, and MS.
27. This crop group tolerance is not adequately supported because residue data are required for peppers. Residue data
are required involving application(s) of the 4 Ib/gal EC formulation on peppers at 0.85% Ib ai/A from field tests
conducted in Israel using a PHI of 5 days and as normally grown for export to the U.S.
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHLORPYRITOS
§158.125 Residue Chemistry
(continued)
28. This crop group tolerance is not adequately supported because residue data are required for two additional com-
modities (cantaloupe or muskmelon and squash).
29. The crop group tolerance is not adequately supported because the registered use patterns for the two required,
representative crops (apples and pears) are highly dissimilar and the tolerances for the residues in or on
apples and pears differ by a factor greater than five.
30. This crop group tolerance is not adequately supported because the established tolerance for chlorpyrifos res-
idues in or on cherries differs by a factor greater than five from established tolerances for resides for the
other members of this group.
31. The crop group tolerance is not adequately supported because residue data are required for two additional
members of this group (Blueberries, and a Rubus spp.). Additional data are required to support the cur-
rently established tolerances for residues in or on strawberries and cranberries.
32. Studies must be conducted in OR and WA to provide residue data from ripe cranberries harvested from plants treated
twice with the 4 Ib/gal EC at 1.5 Ib ai/A as aerial-applied, foliar sprays.
33. Residue data from Studies conducted in CA from mature strawberries, harvested from plants foliarly treated at 1 Ib
ai/A(4 Ib/gal EC) when buds first appear and again 10-14 days later are required. Residue data from mature straw-
berries harvested from plants which had been planted and treated the previous year with the 4 Ib/gal EC at 2 Ib ai/A
as a preplant, soil treatment are needed. In the same studies, a group of plants should also receive two foliar
treatments at 1 Ib ai/A as described in the above data gap, to determine the effect of the combination of uses in the
first year of fruit production. The studies must take place in OR or WA as well as ID.
34. This crop group tolerance is not adequately supported because residue data are required for an additional com-
modity (pecans) of this crop group.
35. This crop group tolerance is not adequately supported because the established tolerance for chlorpyrifos residues
in or on fresh corn and corn grain differs by a factor greater than five from established tolerances for residues
of sorghum and that proposed for wheat. Data are required for two additional members of this crop group (rice and
wheat). Additional data are required for the representative commodity sorghum.
-------
GENERIC LJA-X-A HJSOUIfVEMEBtTa FOR CHUORPYRIFOW
§158.125 Residue Chemistry
(continued)
36. The following additional data are required: a. Residue data reflecting three foliar treatments, applied at 3-day
intervals, of the 4 Ib/gal EC formulation at 0.25 Ib ai/A. Treatments must begin when 50% of the seed heads are
in bloom. Both aerial and ground application data are required. Tests must be conducted in KS. b. Residue data
from FL reflecting an at-planting application of the 15% G formulation (state label no. FL820030) applied as a
band over the row and incorporated at 2 Ib ai/A with a 30-inch row spacing. This application must be followed
by foliar applications of the 4 Ib/gal EC formulation as described in the data gap above, c. Residue data from
TX reflecting the following successive treatments: (i) seed treatment with the 50% WP formulation (state label
no. TX 810001) at 1-2 oz ai/100 Ib of seed; (ii) at-planting application of the 15% G formulation (state label
no. TX820021) applied as a band over the row and incorporated at 1.3 Ib ai/A with a 30-inch row spacing; and (iii)
foliar applications of the 4 Ib/gal EC formulation as described in the first data gap presented here.
37. This crop group tolerance is not adequately supported because the established tolerance for chlorpyrifos res-
idues in or on corn forage differs by a factor greater than five from established tolerances for resides of
sorghum forage. Data are required for an additional member of this crop group (wheat). Additional data are
required for the representative commodity sorghum.
38. The following additional data are required: a. Residue data reflecting three foliar treatments, applied at 3-day
intervals, of the 4 Ib/gal EC formulation at 0.25 Ib ai/A. Treatments must begin when 50% of the seed heads are
in bloom. Both aerial and ground application data are required. Tests must be conducted in KS. Forage should
be cut and analyzed 14 days after the last treatment. Also forage (green plants) cut 14 days after the last ap-
plication and dried for fodder and ensiled for silage must also be analyzed for residues, b. Residue data from
FL reflecting an at-planting application of the 15% G formulation (state label no. FL820030) applied as a band
over-the-row and incorporated at 2 Ib ai/A with a 30-inch row spacing. This application should be followed by
foliar applications of the 4 Ib/gal EC formulation as described in the data gap above. Plants must be harvested
14 days after the final treatment and analyzed immediately (forage), and following drying for fodder and ensiling
for silage, c. Residue data from TX reflecting the following successive treatments: (i) seed treatment with the 50%
WP formulation (state label no. TX 810001) at 1-2 oz ai/100 Ib of seed; (ii) at-planting application of the 15% G
formulation (state label no. TX820021) applied as a band over the row and incorporated at 1.3 Ib ai/A with a 30-inch
row spacing; and (iii) foliar applications of the 4 Ib/gal EC formulation as described in the first data gap presented
here. Plants must be harvested 14 days after the final treatments and analyzed immediately (forage), anb following
drying for fodder and ensiling for silage. Alternatively, the registrant may propose a feeding and grazing restric-
tion for forage and fodder.
39. This crop group tolerance is not adequately supported because residue data are required for an additional com-
modity (clover) of this crop group. Additional data are required to support the established tolerance for
alfalfa.
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHLORPYRIPOS
§158.125 Residue Chemistry
(continued)
40. Additional data are required for the following: a. Data reflecting combined residues of chlorpyrifos and TCP in or
on alfalfa forage and hay 14 days after the fourth aerial application of the 4 Ib/gal EC at 0.5 Ib ai/A and 21 days
after the fourth aerial application of the 4 Ib/gal EC at 1 Ib ai/A. Cuttings must be made after each application.
Additional data should also reflect the level of residues of chlorpyrifos and TCP reflecting the maximum use in the
individual cuttings, b. A processing study to determine residues in meal processed from field-treated hay containing
detectable weathered residues; if residues are found to concentrate in meal, a feed additive tolerance must be pro-
posed.
41. This crop group tolerance is not adequately supported because residue data are required for additional com-
modities of this crop group (basil, chives, marjoram, and sage).
42. The residue data for chlorpyrifos on beans, peas, and lentils can be translated to dill.
43. Information for regulatory purposes (representative labels, English translation of labels etc.) must be collected
and submitted on chlorpyrifos usage on bananas in countries which export bananas to the U.S.
44. Data must be submitted reflecting residues in or on cottonseed at harvest following five applications. Data for
both aerial and ground applications must be presented. These tests must be conducted in CA.
45. Data must be submitted reflecting residues in or on fresh figs 7 months following soil application of the 4 Ib/
gal EC formulation at 2 Ib ai/A. Tests must be conducted in CA. Residue data should be submitted on dried figs
processed for fresh figs which were treated at the maximum recommended use rate; if residues are found to con-
centrate in dried figs, an appropriate food additive tolerance must be proposed.
46. The tolerance for okra as a member of the seed and pod vegetable must be eliminated. None of the submitted
residue data for chlorpyrifos can be translated to okra. If the petitioner desires to establish a seed-treatment
use for okra identical to the currently registered use, the following residue data will be required:
a. Residue data from okra pods harvested at the time of their normal maturity, obtained from plants grown from
seed treated at 1 oz ai/100 Ib seed (50% WP). The studies must take place in TX and GA.
47. Metabolism studies of chlorpyrifos in animals are required. Should the metabolites of concern differ from those cur-
rently sought and reported here, additional data will be required.
-------
GENERIC DATA REQUIREMENTS FOR CHUORPYRIFOS
Data Requirement
1 Use 2
Composition Pattern '
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Must Additional
Data Be Submitted
Bibliographic Under FIFRA Section
Citation 3(c)(2)(B)?3
§158.130 Environmental Fate
DEGRADATION STUDIES-LAB;
161-1 - Hydrolysis
Photodegradat ion
161-2 - In water
161-3 - On soil
161-4 - In Air
METABOLISM STUDIES-LAB;
162-1 - Aerobic Soil
162-2 - Anaerobic Soil
162-3 - Anaerobic Aquatic
162-4 - Aerobic Aquatic
MOBILITY STUDIES:
TGAI or PAIRA A,B,D,F,G,H
TGAI or PAIRA A,B,D,G
TGAI or PAIRA A
TGAI or PAIRA A,B,F,G
TGAI or PAIRA A,B,G
TGAI or PAIRA A
TGAI or PAIRA D,G
TGAI or PAIRA D
163-1 - Leaching and TGAI or PAIRA A,B,F,G,H
Adsorpt ion/Desorpt ion
163-2 - Volatility (Lab)
163-3 - Volatility (Field)
TEP
TEP
A,F,G,I*
A,F,I
No
No
No
No
Yes
Yes
No
No
No
No
No
00073059,00095381
00025619
00025619
Yes4
Yes 4
No
No
Yes 3
Yes
Yes4
Yes4
Plus corimercial establishments, pet/animal housing.
-------
TABLE A
GENERIC DATA REQUIREMENTS FUR CHLORPYRIKJS
Data Requirement
1 Use 2
Composition Pattern
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3
§158.130 Environmental Fate '• •
(continued)
DISSIPATION STUDIES-FIELD:
164-1 - Soil TEP A,B,G,H
164-2 - Aquatic (Sediment) TEP D
164-3 - Forestry TEP G
164-4 - Combination and
No
No
No
N/A
Yes3
Yes3
Yes3
No5
Tank Mixes
164-5 - Soil, Long-term
ACCUMULATION STUDIESi
165-1 - Rotational Crops
(Confined)
165-2 - Rotational Crops
(Field)
165-3 - Irrigated Crops
165-4 - In Fish
165-5 - In Aquatic Non-Target
Organisms
TEP
Yes
PAIRA A
TEP A
TEP 0
TGAI or PAIRA A,B,D,G,H
TEP A,B,D,G,H
No
No
No
No
No
00025619,00095381
00073059
No6
Yes3
Yes3
Yes3
Yes3
Yes3
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHUORPYRIPOS
§158.130 Environmental Fate
(continued)
1. Composition: TGAI = Technical grade of the active ingredient; PAIRA = Pure active ingredient, radiolabelled;
TEP = Typical end-use product.
2. The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Cran; F=Gre>gnhouse/ Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
3. Data must be submitted no later than CT/I
4. Data must be submitted no later than
5. This Guidance Document deals only with single active ingredients.
6. The data which were submitted for aerobic soil metabolism meet this requirement.
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR CHLORPYRIFOS
Data Requirement
§158.135 Toxicology
ACUTE TESTING:
81-1 - Acute Oral - Rat
81-2 - Acute Dermal
81-3 - Acute Inhalation - Rat
81-7 - Acute Delayed
Neurotoxicity - Hen
SUBCHRONIC TESTINGS
82-1 - 90-Day Feeding -
Rodent, Non-rodent
82-2 - 21-Day Dermal
82-3 - 90-Day Dermal
82-4 - 90-Day Inhalation -
1
Composition
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
Does EPA Have Data
To Satisfy This
Use 2 Requirement? (Yes, Bibliographic
Patterns No or Partially) Citation
A,B,D,F,H,I Yes 00046543
A,B,D,F,H,I Yes 00046543
A,B,D,F,H,I No
A,B,D,F,H,I Yes 00095250
No
N/A
N/A
B,I No
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3
No
No
Yes4
No
No5
No
No
Yes 6
Rat
82-5 - 90-Day Neurotoxicity-
Hen/Mammal
TGAI
N/A
NO
-------
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3
Cata Requirement
1 Use 2
Composition Pattern
Does EPA Have Data
To Satisfy This
Requ i rement ? (Yes,
No or Partially)?
Bibliographic
Citation
§158.135 Toxicology
(continued)
CHRONIC TESTING;
83-1 - Chronic Toxicity -
2 species:
Rodent TGAI
Non-rodent TGAI
83-2 - Oncoyenicity Study -
2 species:
Rat TGAI
Mouse TGAI
83-3 - Teratogenicity - TGAI
2 species
83-4 - Reproduction, TGAI
2-generat ion
MUTAGENICITY TESTING
84-2 - Gene Mutation TGAI
84-2 - Chromosomal Aberration TGAI
84-2 - Other Mechanisms of TGAI
Mutagenicity
A
A
A
A
A,B,,F,H,I
A
A
Partially
Partially
Partially
Partially
Yes
Yes
Partially
Partially
Partially
00029063, 00081270
00029063, 00081270
00081270, 00054352
00081270, 00054352
00064934, 0100203
0100204
00064934, 0100202
05004861, 05010438
00043657, 0100201
0100201
0100201
Yes8,3
Yes7,3
YesV
No
No
YeslO,4
Yes10,4
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR CHLORPYRIFOS
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Use 2 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition Pattern No or Partially) Citation 3(c)(2)(B)?3
§158.135 Toxicology
(continued)
SPECIAL TESTING
85-1 - General Metabolism PAI or PAIRA A Partially 00043244, 100204 Yes11,3
1. Composition: PAI » Pure active ingredient; PAIRA = Pure active ingredient, radio label led; Choice = Choice of several
test substances determined on a case-by-case basis.
2. The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terres trial, Non-Food; C=Aquatic, Food Crop;
D=Aquatic, Non~Ft>od> E=Greenhouse , Food Crop; F=Greenhouse , Non-Food; G=Forestry; H=Domestic Outdoor;
1= Indoor.
3. These data must be submitted no later than
4. These data must be submitted no later than MAR
5. Not required since a chronic feeding study in a" rodent and non-rodent is being required.
6. These data must be submitted no later than T]*
_
7. Only summary data for gross findings and histopathology were available for interim sacrificed and study termination
sacrificed animals. Data were not available on clinical observations and individual animal body weights.
8. Histology data were available for each of the individual tissues examined. Uata were lacking for several parameters
that were monitored (body weight, ophthalmology, etc.) at the intervals specified in the study protocol.
9. Data were not available which indicated that the highest dose tested was the maximum tolerated dose. Ancillary
data are needed which define the suitablilty of the doses used.
10. Available reports are study summaries or abstracts. Full reports are needed.
11. Additional metabolism data are needed to identify and quantify the metabolites of chlorpyrifos.
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHLORPYRIPOS
Data Requirement
1 2
Composition Pattern
Does EPA Have Data
To Satisfy This
Requ i rement ? (Yes,
Mo or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3
§158.140 Reentry Protection
132-1 - Foliar Dissipation TEP A,B,H,
132-1 - Soil Dissipation TEP A,B,H,
133-3 - Dermal Exposure TEP A,B,H,I
133-4 - Inhalation Exposure TEP A,B,H,I
- Dermal and Inhalation TEP B,H,I
Exposure- Monitoring
- Termiticide- Air TEP B,H,I
Monitoring
No
No
No
No
No
No
Yes4
Yes4
Yes4
Yes4
Yes5
1.
2,
3,
4.
Composition: TEP = Typical end-use product; EP = End-use product.
The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food Crop; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crtop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
Data must be submitted no later than
For each use, the registrant is required to propose an acceptable re-entry interval based upon one of the following:
1) the longest, most restrictive existing interval for chlorpyrifos (24 hours-California), or 2) data on dissipation
of residues (decline curve), on human exposure to those residues, and on toxicity of chlorpyrifos; or determination
of that time beyond which there are no detectable dislodgeable or inhalable residues remaining in the worker/occupant
environment.
Studies must be designed to assess human exposure to chlorpyrifos for currently registered uses (at labeled rates)
in domestic and commercial buildings, and on ornamental turf. Protocols must be submitted 90 days from receipt of
this Guidance Document and data must be submitted 18 months after Agency approval of the protocols.
These data have been required under a separate 3(c)(2)(B) letter dated February 23, 1984. Protocols must be sub-
mitted 90 days from receipt of that letter and the data must be submitted 18 months after Agency approval of protocols
for termiticide and other structural insecticide use.
-------
TABLE A
GENERIC DATA REQUIREMENTS FDR CHLORPYRIFOS
Data Requirement
1 Use 2
Composition Pattern
Does EPA Have Data
To Satisfy This
Requ i rement ? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3
§158.145 Wildlife and
Aquatic Organisms
AVIAN AND MAMMALIAN TESTING
71-1 - Acute Avian Oral
71-2 - Acute Avian Dietary
TGAI
TGAI
A,B,D,G
A,B,D,G
Yes
Yes
00051592*, 0100200**
00095125*, 00046955*
00095007*, 00095445*
00046954*, 00095447*
00095448*, 00095446**
00095449**, 00095450**
No
71-3 - Wild Mammal 'Ibxicity
TGAI
No
No
71-4 - Avian Reproduction
71-5 - Simulated and Actual
Field Testing -
Mammals and Birds
AQUATIC ORGANISM TESTING
72-1 - Acute Freshwater Fish
72-2 - Acute Freshwater
Invertebrates
72-3 - Acute Estuarine
and Marine Organisms
TGAI A,B,D,G
TEP A,B,D,G
TGAI
TEP4
TGAI
TEP4
TGAI
TEP4
A,B,D,G
D
A,B,D,G
D
A,B,D,G
D
Yes
Yes
Yes
No
Yes
No
Yes
No
00046951*, 00046952*
00046953*
00095305**, 00095304**
00095114**
00095013*, 0100201*
00095297, 00095321*
00095296**, 00095298**
00102520*, 0100201*
00056603*, 00095126*
No
No
No
Yes
No
Yes
No
Yes
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHLOROPYRIPOS
Data Requirement
1 Use 2
Composition Pattern
Does EPA Have Data
To Satisfy This
Requi rement? (Yes,
No orPartially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?3
§158.145 Wildlife and
Aquatic Organisms
AQUATIC ORGANISM TESTING
(continued)
72-4 - Fish Early Life TGAI A,B,D,G
Stage and Aquatic
Invertebrate Life-Cycle
72-5 - Fish - Life Cycle TGAI A,B,D,G
72-6 - Aquatic Organism
Accumulation
TGAI, PAI or A,B,D,G
Degradation
Product
72-7 - Simulated or Actual TEP A,B,D,G
Field Testing -
Partially
No
No
Partially
0100202*
00095366**, 00102758**
00095356**, 00095366**
00095368**, 00095128**
05000838**, 00104696**
Yes5
No6
No7
Yes8,9,10
Composition: TGAI = Technical grade of the active ingredient; PAI = pure active ingredient;
TEP= Typical end-use product.
The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food Crop; C=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crfop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
Data must be submitted no later than QCT '"1985 •
3.
4.
5.
6.
7.
8.
Testing on Typical end-use product from each of the following categories: EC, granular, and rnicroencapsulated.
Studies have been submitted concerning aquatic invertebrates. A fish embryo-larvae study on cold and warm water
species is still needed.
Depending on the results of the fish early life studies, a fish -life cycle study may be required.
These data may be required pending the results of the Environmental Fate tests.
Large scale testing involving greater than 100 acres are needed. Individual environmental monitoring for crop
runoff is required. Phytotoxic effects of chlorpyrifos on algae and other aquatic plant life is required.
Individual environmental monitoring of crop sites such as corn, etc. are required. Pending the results of
monitoring studies, full field studies may be required.
-------
§158.145 Wildlife and
Aquatic Organisms
AQUATIC ORGANISM TESTING
(continued)~~
9. Data are required for the aquatic, non-food use (mosquito larvicide); however requirement is reserved for use
patterns A, B and Q pending results of environmental fate studies.
10. Protocols for the aquatic, non-food use testing must be submitted within 6 months from receipt of this Guidance
Document.
* Study fulfills Guideline Requirements.
** Study must be combined with other studies to fulfill Guideline Reguirements.
-------
Data Requirements
Composition
Does EPA Have Data
To Satisfy This
Use 2 Requirement? (Yes,
Pattern No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(b)?3
§158.150 Plant Protection
121-1 - TARGET AREA
PHnXJTOXICITY EP
NUNTARGET AREA PHYTOIDXICITY
TIER I
122-1 - Seed Germination/ TGAI
Seedling Emergence
122-1 - Vegetative Vigor TGAI
122-2 - Aquatic Plant Growth TGAI
TIER II
123-1 - Seed Germination/ TGAI
Seedling Emergence
123-1 - Vegetative Vigor TGAI
123-2 - Aquatic Plant Growth TGAI
TIER III
124-1 - Terrestrial Field TEP
124-2 - Aquatic Field TEP
No
No
No
No
No
No
No
No
No
No
No
No
No
No
No
No
1. Composition: TGAI = Technical grade of the active ingredient; TEP = Typical end-use product.
EP = End-use product.
2. The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non-Food Crop; C=Aquatic, Food Crop;
3. These data are not required because it is believed that there is no phytotoxicity problem with chlorpyrifos.
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR CHLORPYRIFOS
Data Requirement
1 Use 2
Composition Pattern
Does EPA Have Data
To satisfy This
Requ i rement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)7
SI58.155 Nontarget Insect
NONTARGET INSECT TEStlNG -
POLLINATORS;
141-1 - Honey bee acute
contact TGAI A,B,H
141-2 - Honey bee - toxicity TEP A,B,H
of residues on
foliage
141-3 - Wild bees important in TEP A
alfalfa pollination -
toxicity of residues
on foliage
141-4 - Honey bee subacute
feeding study
141-5 - Field testing for TEP A,B,H
pollinators
Yes
Yes
Yes
No
00066220, 05001991
00040602
00040602
No
No
No
Reserved3
-------
CJE;IME;JKJ;I_-
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Use 2 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement _ Composition Pattern No or Partially) _ Citation _ 3(c)(2)(B)?
§158.155 Nontarget Insect
(continued)
NONTARGET INSECT TESTING -
AQUATIC INSECTS;
142-1 - Acute toxicity to - - - - Reserved^
aquatic insects
142-2 - Aquatic insect - - - - Reserved^
life-cycle study
142-3 - Simulated or actual - - - - Reserved^
field testing for
aquatic insects
143-1 - NONTARGET INSECT - - ReservedS
TESTING - PREDATORS
thru AND PARASITES
143-3
1. Composition: TGAI - Technical grade of the active ingredient; TL'P = Typical end-use product.
2. The use patterns are coded as follows: A=Terrestriai, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop:
D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=lndoor.
3. Reserved pending development of test methodology.
4. Data fron 1st and 2nd tier studies do not indicate the need for field studies.
5. Reserved pending Agency decision as to whether the data requirement should be established.
15
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRItOS
§158.120 - PRODUCT CHEMISTRY
Guideline Citation and
Name of Test
Product Identity:
61-1 - Identity of Ingredients
61-2 - Statement of Composition
61 3 Discussion Of Fotifldtioii of
Ingredients
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis
62-2 - Certification of Limits
62-3 - Analytical Methods for
Enforcement of Limits
Physical and Chemical Characteristics
63-2 - Color
63-3 - Physical State
63-4 - Odor
63-7 - Density, Bulk Density, or
Test
Substance^
MP
MP
MP
MP
MP
MP
MP
MP
MP
MP
Guidelines Are Data Footnote
Status2 Required Number
Yes No
R IX] H
R IX] H
R [xi n
R [xi n
R ixj n
R IX] M
R ix] n
R [x] M
R IX] H
R [X] M
Specific Gravity
63-12 - pH
MP
R
[X] [ I
-------
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHUORPYRIFOS
§158.120 - PRODUCT CHEMISTRY (Con't)
Guideline Citation and
Name of Test
Physical and Chemical Characteristics
(Continued)
63-14 - Oxidizing or Reducing
Action
63-15 - Flammability
63-16 - Explodability
63-17 - Storage Stability
63-18 - Viscosity
63-19 - Miscibility
63-20 - Corrosion Characteristics
Other Requirements:
64- 1 - Submittal of samples
Test
Substance^
MP
MP
MP
MP
MP
MP
MP
PAI
Guidelines
Status2
CR
CR
R
R
CR
CR
R
CR
Are Data Footnote
Required Number
Yes No
ix] n
[X] ["]
[x] n
[x] n
[X] l"l
ixi n
[x] n
n [x]
1. Test substance: MP = Manufacturing-use product; PAI = Pure active ingredient.
2. Guideline status: R = Required; CR = Conditionally required.
3. These data must be submitted no later than MAR 1985 .
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
Pulvex Flea Free-30 Brand Insecticide Base (59-179)
Does EPA Have Data Must Additional
To Satisty This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2
§158.135
Toxicology
ACUTE TESTING
81-1 -
81-2 -
81-3 -
81-4 -
81-5 -
81-6 -
Oral - Rat MP Yes
Dermal MP Yes
inhalation - Rat MP No
Primary Eye MP Yes
Irritation - Rabbit
Primary Darmal MP Yes
irritation
Dermal Sens itlzat ion MP No
00080022 No
00080022 No
Yes
00080022 No
00080022 No
Yes
1. Composition: MP *» Manufacturing-use product. _ ^
2. Data must be submitted no later than MAR 198B
-------
-TABLE B
PHDDUCt SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHDORPYRIFOS
Ultratec Insecticide Chlorpyrifos Transparent B.C. 25 (432-625)
Data Requirement
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c) (2)(B)?2
§158.135 Toxicology
ACUTE TESTING
81-1 - Oral - Rat
81-2 - Dermal
81-3 - Inhalation - Rat
81-4 - Primary Eye
MP
MP
MP
MP
Yes
Yes
No
Yes
00046543 No
00046543 No
Yes
00046543 No
Irritation - Rabbit
81-5 - Primary Dermal
Irritation
MP
Yes
00046543
No
81-6 - Dermal Sensitization
MP
No
Yes
1. Composition: MP - Manufacturing-use product.
2. Data must be submitted no later than
-------
TABLE B
PRODUCT SPECIFIC CATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
Ultratec Insecticide W/Chlorpyrifos Transparent Emuls. 25 (432-662)
Data Requirement
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Irritation - Rabbit
81-5 - Primary Dermal
Irritation
MP
Yes
OU046543
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2
§158.135 Toxicology
ACUTE TESTING
81-1 - Oral - Rat
81-2 - Dermal
81-3 - Inhalation - Rat
81-4 - Primary Eye
MP
MP
MP
MP
Yes
Yes
No
Yes
00046543 No
00046543 No
Yes
00046543 No
No
81-6 - Dermal Sensitization
MP
No
Yes
1. Composition: MP <* Manufacturing-use product.
2. Data must be submitted no later than
-------
PRODUCT SPECIFIC
Data Requirement
§158.135 Toxicology
ACUTE TESTING
81-1 - Oral - Rat
81-2 - Dermal
81-3 - Inhalation - Rat
81-4 - Primary Eye
Irritation - Rabbit
81-5 - Primary Dermal
Irritation
81-6 - Dermal Sensitization
DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHUJKPX1
Dursban 6 (464-358)
Does EPA Have Data
To Satisfy This
1 Requirement? (Yes, Bibliographic
Composition No or Partially) Citation
•
MP Yes 00046543
MP Yes 00046543
MP No
MP Yes 00046543
MP Yes 00046543
&
MP No
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
Dursban MC (464-381)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement ConDOsition No or Partiallv) Citation 3(c)(2)(B)?2
S158.135
Toxicology
ACUTE TESTING
81-1 -
81-2 -
81-3 -
81-4 -
81-5 -
81-6 -
Oral - Rat MP Yes
Dermal MP Yes
Inhalation - Rat MP No
Primary Eye MP Yes
Irritation - Rabbit
Primary Dermal MP Yes
Irritation
Dermal Senaihization MP No
- ' i-'.-i. !•••—.- '• - !•••«•• il li -,-,„.. , -.„„.„.. I,.,—,,. i— .,„ - . , -
00046543 No
00046543 No
Yes
00046543 No
00046543 No
Yes
1. Composition: MP * Manufacturing-use product.
2. Data must be submitted no later than
MAP
-------
TABLE B
PRODUCt SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
Dursban F (464-404)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2
§158.135
Toxicology
ACUTE TESTING
81-1 -
81-2 -
81-3 -
81-4 -
81-5 -
81-6 -
Oral - Rat MP Yes
Dermal MP Yes
Inhalation - Rat MP No
Primary Eye MP Yes
Irritation - Rabbit
Primary Dermal MP Yes
Irritation
Dermal Sensitization MP No
OOU46543 No
00046543 No
Yes
00046543 No
00046543 No
Yes
1. Composition: MP = Manufacturing-use product.
2. Data must be submitted no later than
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partiallvl Citation 3
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
Dursban R (464-558)
Data Requirement
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliograpnic
Citation
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2
§158.135 Toxicology
ACUTE TESTING
81-1 - Oral - Rat
81-2 - Dermal
81-3 - Inhalation - Rat
81-4 - Primary Eye
MP
MP
MP
MP
Yes
Yes
No
Yes
00080022 No
00080022 No
Yes
00080022 No
Irritation - Rabbit
81-5 - Primary Dermal
Irritation
MP
Yes
00080022
No
81-6 - Dermal Sensitization
MP
NO
Yes
1. Composition: MP = Manufacturing-use product.
2. Data must be submitted no later than
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
Dursban 30 SEC (464-559)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Comoosition No or Partially) Citation 3(c)(2)(B)?2
S158.135
Toxicology
ACUTE TESTING
81-1 -
81-2 -
81-3 -
81-4 -
81-5 -
81-6 -
Oral - Rat MP Yes
Dermal MP Yes
Inhalation - Rat MP No
Primary Eye MP Yes
Irritation - Rabbit
Primary Dermal MP Yes
Irritation
Dermal Sens itizat ion MP No
00080022 No
00080022 No
Yes
00080022 No
00080022 No
Yes
2. Data must be submitted no later than
MAR
-------
PWJUUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHLOKPYRItOS
Dursban MCR (464-564)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under t'IFRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2
§158.135
Toxicology
ACUTE TESTING
81-1 -
81-2 -
81-3 -
81-4 -
81-5 -
81-6 -
Oral - Rat MP Yes
Dermal MP Yes
Inhalation - Rat MP No
Primary Eye MP Yes
Irritation - Rabbit
Primary Dermal MP Yes
Irritation
Dermal Sensitization MP No
00080022 No
00080022 No
Yes
00080022 No
00080022 No
Yes
1. Composition: MP = Manufacturing-use product.
2. Data must be submitted no later than
-------
TABLE B
PFOfiUtt SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
Dursban 6R (464-567)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2
§158.135
Toxicology
ACUTE TESTING
81-1 -
81-2 -
81-3 -
81-4 -
81-5 -
81-6 -
Oral - Rat MP Yes
Dermal MP Yes
inhalation - Rat MP No
Primary Eye MP Yes
Irritation - Rabbit
Primary Dermal MP Yes
Irritation
Dermal Sensitization MP No
00080022 No
00080022 No
Yes
00080022 No
00080022 NO
Yes
1. Composition: MP * Manufacturing-use product.
2. Data must be submitted no later than MAR I9R5
-------
PftS&tfc* SPECIFIC DATA REQUIREMENTS FOR MANUFACTURINC3-USE PRODUCTS CONTAINING
Dursban 5G (464-575)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2
§158.135 Toxicology
ACUTE
81-1
81-2
81-3
81-4
81-5
81-6
TESTING
- Oral - Rat MP Yes
- Dermal MP Yes
- Inhalation - Rat MP No
- Primary Eye MP Yes
irritation - Rabbit
- Primary Dermal MP Yes
Irritation
- Dermal Sensitization MP No
00046543 No
00046543 No
Yes
00046543 No
00046543 No
Yes
1. Composition: MP = Manufacturing-use product.
2. Data must be submitted no later than
-------
TABLE B
PPDDUCt SPECIFIC DATA REQUIREMENTS fOR MANUFACTURING-USE PRODUCTS CONTAINING CHLDRPYRIi-OS
Dursban HF (464-588)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partially) Citation 3{c)(2)(B)?2
§158.135 Toxicology
ACUTE TESTING
81-1 - Oral - Rat MP Yes
81-2 - Dermal , MP Yes
81-3 - inhalation - Rat MP No
I
81-4 - Primary Eye MP Yes
Irritation - Rabbit
81-5 - Primary Dental MP Yes
Irritation
81-6 - Dermal Sensitization MP No
00046543 No
00046543 No
Yes
00046543 No
00046543 No
Yes
1. Composition: MP * Manufacturing-use product.
2. Data must be submitted no later than ujAD • igfjc
-------
PfOtlbCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIPOS
Prentox 10% Chlorpyrifos MG (655-592)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2
§158.135
Toxicology
ACUTE TESTING
81-1 -
81-2 -
81-3 -
81-4 -
81-5 -
81-6 -
Oral - Rat MP Yes
Dermal MP Yes
Inhalation - Rat MP No
Primary Eye MP Yes
Irritation - Rabbit
Primary Dermal MP Yes
Irritation
Dermal Sensitization MP No
00046543 No
00046543 No
Yes
00046543 No
00046543 No
Yes
1. Composition: MP = Manufacturing-use product.
2. Data must be submitted no later than yflp (Qffi;
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS pQR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
.. Prentox 20% Chlorpyrifos MG (655-593)
Data Requirement
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
Bibliographic
Citation
Irritation - Rabbit
81-5 - Primary Dential
Irritation
81-6 - Dermal sensitization
MP
MP
Yes
No
00046543
Must Additional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?2
§158.135 Toxicology
ACUTE TESTING
81-1
81-2
81-3
81-4
- Oral - Rat
- Dermal
- Inhalation - Rat
- Primary Eye
MP Yes
MP Yes
MP No
MP yes
00046543 No
00046543 No
Yes
00046543 No
NO
Yes
1. Composition: MP * Manufacturing-use product.
2. Data must be submitted no later than
-------
PHOOOL.T SPECIFIC
Data Requirement
§158.135 Toxicology
ACUTE TESTING
81-1 - Oral - Rat
81-2 - Dermal
81-3 - Inhalation - Rat
81-4 - Primary Eye
Irritation - Rabbit
81-5 - Primary Dermal
Irritation
81-6 - Dermal sensitization
DATA REQUIREMENTS FOR MANUFACTURING-USE: PRODUCTS
Prentox Pyrifos 25% MG (655-695)
Does EPA Have Data
To Satisfy This
1 Requirement? (Yes,
Composition No or Partially)
MP Yes
MP Yes
MP No
MP Yes
MP Yes
MP No
CONTAINING CHLORPXRIBXJS
Must Additional
Data Be Submitted
Bibliographic Under B'IFRA Section
Citation 3(c)(2)(B)?2
00046543 No
00046543 No
Yes
00046543 No
•
00046543 No
Yes
1. Composition: MP = Manufacturing-use product.
2. Data must be submitted no later than
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE PRODUCTS CONTAINING CHIDRPYRIFOS
Does EPA Have Data Must Additional
To Satisty This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partiallv) Citation 3(c)(2)(B)?2
§158.135
Toxicology
ACUTE TESTING
81-1 -
81-2 -
81-3 -
81-4 -
81-5 -
81-6 -
Oral - Rat MP Yes
Dermal MP Yes
Inhalation - Rat MP . No
Primary Eye MP Yes
Irritation - Rabbit
Primary Dermal MP Yes
Irritation
Dermal Sensltization MP No
OOU80022 No
00080022 No
Yes
00080022 No
00080022 No
Yes
1. Composition: MP * Manufacturing-use product.
2. Data must be submitted no later than '&
-------
PRODUCT1 BPfcCIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CH1ORPYRIFOS
Stephenson Chemicals Big "D" Concentrate (4887-169)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2
§158.135
Toxicology
ACUTE TESTING
81-1 -
81-2 -
81-3 -
81-4 -
81-5 -
81-6 -
Oral - Rat MP Yes
Dermal MP Yes
Inhalation • - Rat MP No
Primary Eye MP Yes
Irritation - Rabbit
Primary Dermal MP Yes
Irritation
Dermal Sensitization MP No
00080022 No
00080022 No
Yes
00080022 No
00080022 No
Yes
1. Composition: MP = Manufacturing-use product.
2. Data must be submitted no later than
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
SMCP DFC-4 Formulators Concentrate (6720-195)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2
§158.135
Toxicology
ACUTE TESTING
81-1 -
81-2 -
81-3 -
81-4 -
81-5 -
81-6 -
Oral - Rat MP Yes
Dermal MP Yes
Inhalation - Rat MP No
Primary Eye MP Yes
Irritation - Rabbit
Primary Dermal MP Yes
Irritation
Dermal Sensitization MP • No
00080022 No
00080022 No
Yes
00080022 No
00080022 No
Yes
1. Composition: MP * Manufacturing-use product.
2. Data must be submitted no later than
J985_
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
D/C-4 (9782-29)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2
§158.135
Toxicology
ACUTE TESTING
81-1 -
81-2 -
81-3 -
81-4 -
81-5 -
81-6 -
Oral - Rat MP Yes
Dermal MP Yes
Inhalation - Rat MP No
Primary Eye MP Yes
Irritation - Rabbit
Primary Dermal MP Yes
Irritation
Dermal., Sens it i2at ion MP No
00046543 No
00046543 No
Yes
00046543 No
00046543 No
Yes
1. Composition: MP = Manufacturing-use product.
2. Data must be submitted no later than
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
Dursban Insect Spray (20954-16)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2
§158.135
Toxicology
ACUTE TESTING
81-1 -
81-2 -
81-3 -
81-4 -
81-5 -
81-6 -
Oral - Rat MP Yes
Dermal MP Yes
Inhalation - Rat MP No
Primary Eye MP Yes
Irritation - Rabbit
Primary Dermal MP Yes
Irritation
Dermal Sensitization MP No
00046543 No
00046543 No
Yes
00046543 No
00046543 No
Yes
1. Composition: MP = Manufacturing-use product.
2. Data must be submitted no later than WAI
-------
PHODUCff SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYRIFOS
SMCP Dursban 10% Granular Insecticide (6720-246)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIPRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2
§158.135 Toxicology
ACUTE TESTING
81-1 - Oral - Rat MP Yes
81-2 - Dermal MP Yes
81-3 - Inhalation - Rat MP No
81-4 - Primary Eye MP Yes
Irritation - Rabbit
81-5 - Primary Dermal MP Yes
Irritation
81-6 - Dermal Sensitization MP No
00046543 No
00046543 No
Yes
00046543 No
00046543 No
Yes
1. Composition: MP = Manufacturing-use product.
2. Data must be submitted no later than . y^p IQOC
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FDR MANUFACTURING-USE PRODUCTS CONTAINING CHLURPYRIFOS
SMCP Dursban-15% Granular Insecticide (6720-245)
Does EPA Have Data Must Additional
To Satisfy This Data Be Submitted
1 Requirement? (Yes, Bibliographic Under FIFRA Section
Data Requirement Composition No or Partially) Citation 3(c)(2)(B)?2
§158.135 Toxicology
ACUTE TESTING
81-1 - Oral - Rat MP Yes
81-2 - Dermal MP Yes
81-3 - Inhalation - Rat MP No
81-4 - Primary Eye MP Yes
Irritation - Rabbit
81-5 - Primary Dermal MP Yes
Irritation
81-6 - Dermal Sensitization MP No
1. Composition: MP » Manufacturing-use product.
2. Data must be submitted no later than MAR---- IQRK
00046543 No
00046543 No
Yes
00046543 No
00046543 No
Yes
f
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING-USE PRODUCTS CONTAINING CHLORPYKIFUS
Insecta No. 101 thru 108 (45600-2 thru-9)
Data Requirement
1
Composition
Does EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Submitted
Under FIt'RA Section
§158.135 Toxicology
ACUTE TESTING
81-1 - Oral - Rat
81-2 - Dermal
81-3 - Inhalation - Rat
81-4 - Primary Eye
MP
MP
MP
MP
Yes
Yes
No
Yes
00080022 No
00080022 No
Yes
00080022 No
Irritation - Rabbit
81-5 - Primary Dermal
Irritation
MP
Yes
00080022
No
81-6 - Dermal Sensitization
MP
No
Yes
1. Composition: MP = Manufacturing-use product.
2. Data must be submitted no later than S^IAR - 1985
-------
IV. SUBMISSION OF REVISED LABELING AND PACKAGING INFORMATION
Note: This section applies to end-use products only to the
the extent described under Section II of this document.
Otherwise, the following information pertains exclusively to
manufacturing-use products.
The Agency requires applicants for registration or reregistra-
tion to ensure that each label (1) contains accurate, complete,
and sufficient instructions and precautions, reflecting the
results of data concerning the product and its ingredients, and
(2) incorporates labeling format and terminology which are suffi-
ciently standardized to avoid user confusion.
As part of your application, you will be required to submit
draft labeling consistent with: applicable product-specific
data; the precautionary statements and use directions; and the
regulations concerning classification [40 CFR §162.11(c)], pack-
aging [40 CFR §162.16], and labeling [40 CFR §162.10, Appendix
IV-1 an IV-2], as indicated by the following paragraphs of this
chapter of the guidance document.
If owners of currently registered products fail to submit
revised labeling and packaging information complying with this
Section and/or Section II, EPA may issue a notice of intent to
cancel the registration under FIFRA §6(b)(l).
All labeling changes must appear on all products released
for shipment one year from the date this Guidance Document is
issued.
A. Label Contents
40 CFR §162.10 (Appendix IV-1) requires that certain spe-
cific labeling statements must appear at certain locations
on the label. This is referred to as format labeling.
Specific label items listed below are keyed to Tables D, E,
and F (Appendix IV-2).
Item 1. PRODUCT NAME - The name, brand, or trademark is
required to be located on the front panel, preferably centered
in the upper part of the panel. The name of a product will
not be accepted if it is false or misleading. See Appendix
IV-1. [40 CFR §162.10(b)J
Item 2. COMPANY NAME AND ADDRESS - The name and address
of the registrant or distributor is required on the label.
The name and address should preferably be located at the
bottom of the front panel or at the end of the label text.
See Appendix IV-1. [40 CFR $162.10(c)]
Item 3. NET CONTENTS - A net content statement is required
', on all labels. The preferred location is the bottom of the
front panel immediately above the company name and address,
or at the end of the label text. The net contents must be
stated in terms of weight, expressed as avoirdupois pounds
38
-------
and. ounces, and stated in terms of the largest suitable unit,
i.e., "1 pound 10 ounces" rather than "26 ounces." In
addition to the required units specified, net contents may be
expressed in metric units. See Appendix IV-1. [40 CFR
§162.10(d)]
Item 4. EPA REGISTRATION NUMBER - The registration
number assigned to the pesticide product must appear on the
label, preceded by the phrase "EPA Registration No.," or "EPA
Reg. No." The registration number must be set in type of a
size and style similar to other print on that part of the
label on which it appears and must run parallel to it. The
registration number and the required identifying phrase must
not appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Agency. See Appendix IV-1.
[40 CFR §162.10(e)]
Item 5. EPA ESTABLISHMENT NUMBER - The EPA establishment
number, preceded by the phrase "EPA Est." is the final estab-
lishment at which the product was produced, and may appear
in any suitable location on the label or immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment registration number on
the immediate container cannot be clearly read through such
wrapper or container. See Appendix IV-1. [40 CFR §162.10(f)J
Item 6. INGREDIENT STATEMENT - An ingredient statement
is required on the front panel and must contain the name and
percentage by weight of each active ingredient and the total
percentage by weight of all inert ingredients. The preferred
location is immediately below the product name. The ingredient
statement must run parallel with, and be clearly distinguished
from, other text on the panel. It must not be placed in the
body of other text. See Appendix IV-1. [40 CFR 162.10(g)]
Item 6A. POUNDS PER GALLON STATEMENT - For liquid
agricultural formulations, the pounds per gallon of active
ingredient must be indicated on the label.
Item 7 FRONT LABEL PRECAUTIONARY STATEMENTS - All labels
are required to have precautionary statements grouped together
on the front panel, preferably within a block outline. The
table below shows the minimum type size requirements on
various size labels, as set forth in the Regulations.
39
-------
Size of Label Signal Word as Re- "Keep Out of Reach
on Front Panel quired Minimum Type of Children"
in Square Inches Size All Capitals as Required
5 and under 6 point 6 point
above 5 to 10 10 point 6 point
above 10 to 15 12 point 8 point
above 15 to 30 14 point 10 point
over 30 18 point 12 point
Item 7A. CHILD HAZARD WARNING STATEMENT - All labels are
required to have the statement "Keep Out of Reach of Children"
located on the front panel above the signal word except where
contact with children during distribution or use is unlikely.
See Appendix IV-1. [40 CFR §162.10(h)(1)(ii)]
Item 7B. SIGNAL WORD - The signal word (Caution, Warning,
or Danaer) is required on the front panel immediately below
the child hazard warning statement. See Appendix IV-1.
[40 CFR §162.10 (h)(l)(i)]
Item 7C. SKULL & CROSSBONES AND WORD "POISON" - On products
assigned a toxicity Category I on the basis of oral, inhala-
tion, or dermal toxicity, the word "Poison" shall appear on
the label in red on a background of distinctly contrasting
color and the skull and crossbones shall appear in immediate
proximity to the word poison. See Appendix IV-1. [40 CFR
§162.10(h)(l)(i)J
Item 7D. STATEMENT OF PRACTICAL TREATMENT - A statement
of practical treatment {first aid or other) shall appear on
the label of pesticide products in toxicity Categories I,
II, and III. See Appendix IV-1. [40 CFR §162.10(h)(1)(iii)]
Item 7E. REFERRAL STATEMENT - The statement "See Side
(or Back) Panel for Additional Precautionary Statements" is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
See Appendix IV-1. [40 CFR §162.10(h)(1)(iii)]
Item 8. SIDE/BACK PANEL PRECAUTIONARY LABELING - The
precautionary statements as listed below must appear together
on the label under the heading "PRECAUTIONARY STATEMENTS."
The preferred location is at the top of the side or back
panel preceding the directions for use, and it is preferred
that these statements be surrounded by a block outline. Each
of the three hazard warning statements must be headed by the
appropriate hazard title. See Appendix IV-1. [40 CFR §162.10
40
-------
Item 8A. HAZARD TO HUMANS AND DOMESTIC ANIMALS - Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route(s) of exposure and the precautions taken to avoid
accident, injury or damage. See Appendix IV-1. [40 CFR §162.10
(h)(2)(i)]
Item 8B. ENVIRONMENTAL HAZARD - Where a hazard exists to
non-target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, injury, or damage. See Appendix IV-1. [40 CFR
.10(h)(2)(ii)]
Item 8C. PHYSICAL OR CHEMICAL HAZARD
1. Flammability statement. Precautionary statements
relating to flammability of a product are required
to appear on the label if it meets the criteria in
Appendix IV-3. The requirement is based on the results
of the flashpoint determinations and flame extension
tests required to be submitted for all products.
These statements are to be located in the side/back
panel precautionary statements section, preceded by
the heading "Physical/Chemical Hazards." Note that
no signal word is used in conjunction with the flam-
mability statements.
2. Criteria for declaration of non-flammability. The
following criteria will be used to determine if a.
product is non-flammable:
a. A "non-flammable gas" is a gas (or mixture of
gases) that will not ignite when a lighted match
is placed against the open cylinder valve.
b. A "non-flammable liquid" is one having a flash-
point greater than 350°F (177°C) as determined
by the method specified in 40 CFR §163.61-8(0(13)
(ii) of Subpart D.
c. A "non-flammable aerosol" is one which meets the
following criteria:
i. The flame extension is zero inches, using the
method specified in 40 CFR §163.61-8(c)(13)(ii);
ii. There is no flash back; and
iii. The flashpoint of the non-volatile liquid
component is greater than 350°F (177°C),
determined by the method specified in 40 CFR
Sl63.61-8(c)(13)(i).
41
-------
3. Declaration of non-flammability. Products which meet
the criteria for non-flammability specified above may
bear the notation "non-flammable" or "nonflammable
(gas, liquid, etc.)" on the label.
It may appear as a substatement to the ingredients
statement, or on a back or side panel, but shall not
be highlighted or emphasized (as with an inordinately
large type size) in any way that may detract from
precaution.
4. Other physical/chemical hazard statements. When
chemistry data submitted in accordance with 40 CFR
§163.61-10(c) demonstrate hazards of a physical or
chemical nature other than flammability, appropriate
statements of hazard will be prescribed. Such
statements may address hazards of explosivity,
oxidizing or reducing capability, or mixing with
other substances to produce toxic fumes.
Item 9. MISUSE STATEMENT - The following statement is
required on your label: "It is a violation of Federal law to
use this product in a manner inconsistent with its labeling."
See Appendix IV-1. [40 CFR §162.10(1)(2)(ii)]
Item 10A. STORAGE AND DISPOSAL BLOCK - All labels are
required to bear storage and disposal statements. These
statements are developed for specific containers, sizes, and
chemical content. Make certain that the statement you use
pertains specifically to your product. These instructions
must be grouped and appear under the heading "Storage and
Disposal" in the directions for use. This heading must be
set in the same type sizes as required for the child hazard
warning. Refer to Appendix IV-5 for the latest specific
storage and disposal product label statements.
Item 10B. DIRECTIONS FOR USE - Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide. When followed, directions must be adequate to
protect the public from fraud and from personal injury and to
prevent unreasonable adverse effects on the environment. See
Appendix IV-1. [40 CFR §162.10]
B. Collateral Information
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, and other graphic printed matter which is referred to
on the label or which is to accompany the product are termed
collateral labeling. Such labeling may not bear claims or
representations that differ in substance from those accepted
in connection with registration of the product. It should be
made part of the response to this notice and submitted for
review.
42
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V. INSTRUCTIONS FOR SUBMISSION
All applications prepared in response to this Notice should
be addressed as follows:
Product Manager: Jay S. Ellenberger (PM 12)
Phone No. (703) 557-2386
Registration Division (TS-767)
Office of Pesticide Programs
Environmental Protection Agency
401 M St., S.W.
Washington, D.C. 20460
For each product for which continued registration is desired:
1. Within 90 days from receipt of this document, you must
submit the "FIFRA Section 3(c)(2)(B) Summary Sheet" EPA
Form 8580-1. Refer to Appendix II-2 with appropriate
attachments.
2. Within 6 months from receipt of this document registrants
must submit:
a. Confidential Statement of Formula, EPA Form 8570-4.
b. Product Specific Data Report, EPA Form 8580-4 (Appendix
III-l).
c. Two copies of any required product-specific data.
d. Two copies of draft labeling, including the label and
associated brochures. If current labeling conforms
to the requirements of this guidance document and the
results of the short-term data, the registrant may
submit such labeling. (End-use product labeling
needs to comply specifically with the instruction in
Section II of this guidance document.) The labeling
should be either typewritten text on 8-1/2 x 11 inch
paper or a mockup of the labeling suitable for
stortage in 8-1/2 x 11 inch files. The draft label
must indicate the intended co-lors of the final label,
clear indication of the front panel label, and the
intended type sizes of the text.
3. Within the time set forth in Table A, all generic data
must be submitted by the affected registrant(s).
Note: If for any reason any required test is delayed or aborted
so that meeting the agreed submission time will be delayed,
notify the Product Manager listed above.
After the Supreme Court has ruled on the Union Carbide Agri-
cultural Products Co. Inc., et. al.'v. Ruckelshaus Decision,
you will be informed as to when you must submit your Application
for Amended Pesticide Registration (EPA Form 8570-1) and the
associated data support information.
43
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APPENDIX II-l
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION GUIDANCE DOCUMENT BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registration Under this Guidance Document
GS0100001 Bauriedel, W.R. 1976. Identification of chlorpyrifos residue
in corn plants. Correspondence to R.W. Morgan dated September
9 and submitted by Dow Chemical Co. under PP#6F1777.
GS0100002 Bauriedel, W.R., and J.H. Miller. 1980. The metabolic fate of
14c-chlorpyrifos applied to an apple tree. Dated December
24 and submitted by Dow Chemical Co. under Section D of
PP#OF2281(09942).
GS0100003 Bauriedel, W.R. and J.H. Miller. 1981. The metabolic fate of 14c-
chlorpyrifos applied topically to soybeans. Dated March 2
and submitted by Dow Chemical Co. under section D of PP#OF2281
(09942).
GS0100004 Smith, G.N., B.S. Watson, and F.S. Fischer. 1967. Investiga-
tions on Dursban insecticide. Uptake and translocation of [36C1]
O,O-diethyl 0-3,5,6-trichloro-2-pyridyl phosphorothioate and
[14C]0,0-diethyl 0-3,5,6-trichloro-2-pyridyl phosphorothioate by
beans and corn. J. Agric. Food Chan, Vol. 15, Jan/Feb. 1967,
No. 1, pp. 127-131; submitted by Dow Chemical Co. under PP#
3F1306 (117938).
GS0100005 Smith, G.N., B.S. Watson, and F.S. Fischer. 1967. Investiga-
tions on Dursban insecticide. Metabolism of 0,0,-diethyl
0-3,5,6-trichloro-2-pyridyl phosphorothioate and 3,5,6-trichloro-
2-pyridinol in plants. J. Agric. Food Chem., Vol. 15, Sept ./Oct.
1967, No. 5, pp. 870-877, submitted by Dow Chemical Co. under
Section D of PP#3F1306(117938).
GS0100006 Analytical Development Corp. 1980. Project no. 577; Report no.
GH-C 1408R: Determination of 14C-residues following oral
administration of 14C-chlorpyrifos to lactating goats. Pre-
pared for and submitted by Dow Chemical Co. under PPf9F2270
(070176).
GS0100007 Betz, Fred. Evironmental Safety Section, EEB, EPA. Memo of
2/28/78 pertaining to mosquito larvacide label. EPA subject
file for chlorpyrifos.
GS0100008 Cunnings, Joseph G., Chief, Chemistry Branch, Regitration Division,
EPA. Letter of 4/12/77 to Dr. M. L. Leng of. Dow Chemical Co.
Contained in the EPA subject file for chlorpyrifos.
GS0100009 Dow Chemical Co. 1970. Report no. OL3132: An analytical method
for the determination of 3,5,6-trichloro-2-pyridinol in animal
tissues and the metabolism of the pyridinol in rats. Submitted '
under PPt3F1306(117938).
-------
-2-
GS0100010 Dow Chemical Co. 1970. Report no. R-582: Comparative metabolism
of insecticides. I. Preliminary studies of ring labeled 0,0-
diethyl-0,3,5,6-trichloro-2-pyridyl phosphorothioate breakdown
with rat liver microsomes. Submitted under PP#3F1306(117938).
GS0100011 Dow Chemical Co. 1971. Report no. NBA-9: Absorption, excretion,
and distribution of 0-0-diethyl 0-3,5,6-trichloro-2,6-C14-2-
pyridyl phosphorothiate (C-14 - Dowco 179) in rats. Submitted
under PPf3F1306(117938).
GS0100012 Dow Chemical Co. 1971. Report no. NBA-10: Absorption, excretion
and distribution of 3,5,6-trichloro-2,6-cl4-2pyridinol in
rats. Submitted under PP#3F1306(117938).
GS0100013 Dow Chemical Co. 1972. Report no. NBE-5R: Dehalogenation of
chlorpyrifos in Australian cattle dip solutions. EPA subject
file for chlorpyrifos.
GS0100014 Dow Chemical Co. - Australia. Appendixes 1-13 submitted originally
to the Australia Department of Primary Industry and submitted
to EPA as attachments to the letter of Robert Morgan dated
8/22/77 and contained in the EPA subject file for chlorpyrifos.
GS0100015 Dow Chemical Co. 1981. Report no. GS-C 1408: The metabolic fate
of i4C-chlorpyrifos fed to lactating goats. Submitted under
PPf9F2270 (070176).
GS0100016 Dow Chemical Co. 1981. Report no. GS-C 1408R: The metabolic
fate of l4-chlorpyrifos fed to lactating goats. Submitted
under PPI9F2270 (070176).
GS0100017 Eto, M. Qrganophosphorus Pesticides: Organic and Biological
Chemistry, CRC Press, Cleveland, Ohio, 1074, pp. 240-253.
GS0100018 Gutenmann, W.H., L.E. St. John, Jr., and D.J. Lisk. 1968.
Metabolic studies with 0,0-diethyl 0-(3,5,6-trichloro-2-pyridyl)
phosphorotioate (Dursban) insecticide in a lactating cow. J.
Agric. Food Chem. 16(1): 45-47. Submitted by Dow Chemical Co.
under PP#3F1306 (117938).
GS0100019 Lores, Emile M., G. Wayne Sovocool, Robert L. Harless, Nancy K.
Wilson, and Robert F. Moseman. 1976. A new metabolite of
chlorpyrifos: Isolation and identification. J. Agric. Food
Cheni. 26(1): 118-122.
GS0100020 Luke, Barry G. and Colin J. Dahl. 1976. Detection of 0,0-diethyl-
0-(2,5-dichlorophenyl)phosphorothioate and 0-0,diethyl-0-(3,6-
dichloro-2-pyridyl)phosphorothioate in meat fat. Journal of
the ACftC 59(5) .-1081-1087.
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GS0100021 Morgan, Robert W; Dow Chemical Co. Letter of 8/22/77 to Mr. Joseph
G. Cunnings, Chief, Chemistry Branch, EPA. Contained in the
EPA subject file for chlorpyrifos.
GS0100022 Shah, P.V., R.J. Monroe, and F.E. Guthrie. 1981. Comparative
rates of dermal penetration of insecticides in mice. Toxicology
and Applied Pharmacology 59:414-423.
GS0100023 Smith, Grant N., Betty S. Watson, and Faye S. Fischer. 1966. The
metabolism of [14C]0,0-diethyl 0-(3,5,6-trichloro-2-
pyridyl)phosphorothioate (Dursban) in fish. J. Econ. Entonol.
59(6):1464-1475. Submitted by Dow Chemical Co. under PP#3F1306
(117938).
GS0100024 Smith, Grant N., Betty S. Watson, and Faye S. Fischer. 1967.
Investigations on Dursban Insecticide. Metabolism of [36C1]O-
O-diethyl 0-3,5,6-trichloro-2-pyridyl phosphorothioate in
rats. J. Agric. Food Chem. 15(1):132-138. Submitted by Dow
Chemical Co. under PP#3F1306(117938).
GS0100025 Claborn, H.V., Mann, H.D. and Oehler, D.D. 1968. Dursban
determination in milk and body tissues of cattle. J.A.O.A.C.
51(6):1243-1245. Submitted under Section D of PPf9G0817(11609).
Dow Chemical Co. 1969.
GS0100026 Dow Chemical Co. 1969. Determination of residues of chlorpyrifos
and its oxygen analog in peaches by gas chromatography, by
H.J. Dishburger, J.R. Rice, and J. Pennington. Submitted
under PPt3F1306(117943).
GS0100027 Dow Chemical Co. 1970. Determination of residues of 3,5,6-
trichloro-2-pyridinol in bovine tissues by gas chromatography.
Method no. ACR 70.19 by McKellan, R.L. and Dishburger, H.J.
Submitted under Section D of PP#3F1306(117943).
GS0100028 Dow Chemical Co. 1971. Determination of residues of O-O-diethyl
0-( 3,5,6-trichloro-2-pyridyl)phosphorothioate (chlorpyrifos)
and 0,0-diethyl 0-(3,5,6-trichlofo-2-pyridyl)phosphate in
peaches by gas chromatograph with flame photometric detection.
Method No. ACR 71.14, by Wetters, J.H. and Dishburger, H.J.
Submitted under Section D of PP#3F1306(117946).
GS0100029 Dow Chemical Co. 1971. Determination of residues of 3,5,6-
trichloro-2-pyridinol in corn grain, forage and stover by gas
chromatography. Method No. ACR 71.9 by McKellar, R.L.
Submitted under Section D of PP#3F1306 (117946).
GS0100030 Dow Chemical Co. 1971. Determination of residues of 0,0-diethyl 0-
(3,5,6-trichloro-2-pyridyl)phosphorothioate in corn by gas
chromatography with flame photometric detection. Method no.
ACR 71.18, by Wetters, J.H. and Dishburger, H.J. submitted
under Section D of PP#3F1306(117946).
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GS0100031 Dow Chemical Co. 1971. Determination of residues of 0,0-diethyl
0-3, 5,6,-trichloro-2-pyridyl phosphorothioate in milk and
cream by gas chromatography. Method No. ACR 71.1 by Craig
L.F. Submitted under Section D of PP#3F1306 (117946).
GS0100032 Dow Chemical Co. 1971. Determination of residues of 3,5,6-
trichloro-2-pyridinol in milk and cream by gas chromatography.
Method ACR 71.2 by McKellar, R.L. Submitted under Section D
of PP|3F1306(117946).
GSO100033 Dow Chemical Co. 1972. Determination of residues of 3,5,6-
trichloro-2-pyridinol in swine tissues by gas chromatography
method no. ACR 72.2 by McKellar R.L. Submitted under Section
D of PP#3F1306(117943).
GS0100034 Dow Chemical Co. 1972. Determination of residues of 0,0-diethyl
0-( 3,5,6-trichloro-2-pyridyl)phosphorothioate in swine tissues
by gas chromatography with flame phomometric detection. Method
No. ACR 72.1 by Wetters, J.L. Submitted under Section D of
PPf3F1306( 117943).
GS0100035 Dow Chemical Co. 1972. Determination of residues of O,Odiethyl
0-(3,5,6-trichloro-2-pyridyl)phosphorothioate in chicken
tissues and eggs by gas chromatography with flame photometric
detection. Method no. ACR 72.3 by Wetters, J.H. Submitted
under Section D of PP#3F1306(117946).
GS0100036 Dow Chemical Co. 1972. Determination of residues of chlorpyrifos
and 3,5,6-trichloro-2-pyridinol in or on bananas grown in
chlropyrifos-impregnated polyethylene bags (Shrouds). Method
Nos. ACR 72.13 and 72.14 by Herman, J.L. and Dishburger, H.J.
Section D of PPf3F1370( 118172).
GS0100037 Dow Chemical Co. 1972. Determination of residues of 0,0-diethyl
0-(3,5,6-trichloro-2-pyridyl)phosphorothioate in sweet corn by
gas chromatography with flame photometric detection. Method
No. 72.9, by Wetters, J.H. Submitted under Section D of
PPf4F1445(118407).
GS0100038 Dow Chemical Co. 1972. Determination of residues of 0,0-diethyl
0-(3,5,6-trichloro-2-pyridyl)phosphorothioate in snapbeans and
snapbean forage by gas chromatography. Method No. ACR 72.15,
by McReller, R.L. Submitted under Section D of PP#4F1445(118407)
GS0100039 Dow Chemical Co. 1973. Determination of residues of 0,0-diethyl 0-
(3f5,6-trichloro-2-pyridyl)phosphorothioate in sugar beet
liquid process fractions by gas chrcraatography. Method No.
ACR 73.6 by Wetters, J.H. Submitted under Section D of
PP#1F2527(070368).
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GS0100040 Dow Chemical Co. 1973. Determination of residues of 3,5,6-
trichloro-2-pyridinol in bovine tissues by gas chrcmatography.
Method no. ACR 70.19R by McKellar, R.L. and Dishburger, H.J.
Submitted under Section D of PP#3F1306(117933).
GSO100041 Dow Chemical Co. 1973. Determination of residues of 3,5,6-
trichloro-2-pyridinol in peaches by gas chrcmatography. Method
no. ACR 71.11$, by R.L. McKellar. Submitted under Section D
of PP#3F1306(117336).
GS0100042 Dow Chemical Co. 1973. Determination of residues of 3,5,6-
trichloro-2-pyridinol in lema and snapbean forage and beans by
gas chromatography. Method No. ACR 71.19R by McKellar, R.L.
Submitted under Section D of PP#4F1445(118407).
GS0100043 Dow Chemical Co. 1973. Determination of residues of 0,0-diethyl
0-(3,5,6-trichloro-2-pyridyl)phosphorothioate in sugar beets
and solid process fractions by gas chromatography. Method No.
ACR 73.5 by Wetters, J.H. Submitted under Section D of
PP#6F1745.
GS0100044 Dow Chemical Co. 1974. Determination of residues of 0,0-diethyl
0-(3,5,6-trichloro-2-pyridyl)phosphorothioate in cottonseed
and cotton gin trash by gas chromatography. Method No. ACR
74.4T by McKellar, R.L. Submitted under Section D of
PP#5G1595(119148).
GS0100045 Dow Chemical Co. 1975. Determination of residues of chlorpyrifos
and 3,5,6-trichloro-2-pyridinol in cotton seed, gin trash and
process fractions following multiple treatments of cotton
plants with Lorsban insecticide. Method No. 75.IT by McKellar,
R.L. and Disburger, H.J. Submitted under Section PP#5G1595(119148)
GS0100046 Dow Chemical Co. 1975. Determination of residues of 0,0-diethyl
0-(3,5,6-trichloro-2-pyridyl)phosphorothioate in sweet potatoes
by gas chromatography. Method ACR 75.4 by Wetters, J.H.
Submitted under Section D of PP#6F1786.
GS0100047 Dow Chemical Co. 1976. Residues of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol in sorghum green plant, silage, dry
plant and grain following multiple applications with Lorsban
insecticide. Method No. ACR 76.3 by Wetters, J.H. and
Dishburger, H.J. Submitted under Section D of PP#6F1830.
GS0100048 Dow Chemical Co. 1976. Residues of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol in/on tomatoes grown in Mexico following
multiple foliar applications of Lorsban insecticide. Method
No. ACR 76.9 by Miller, P.W. and Ervick, O.K. Submitted under
Section D of PP#8E2092(097157).
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GS0100049 Dow Chemical Co. 1977. Determination of residues of chlorpyrifos
and 3,5,6-trichloro-2-pyridinol in fresh tomatoes, juice and
paste from Israel following multiple treatment with Dursban 4
insecticide. Method No. EEC 76.1 by Hollick, C.B. and lesson,
D.I. Submitted under Section D of PP# 8E2092(097157).
GS0100050 Dow Chemical Co. 1978. Determination of residues of chlorpyrifos
in alfalfa by gas chromatography method no. ACR 78.10 by
Wetters, J.R. Submitted under Section D of PP#OF2281(099038).
GS0100051 Guinivan, R.A., N.P. Thompson and P.C. Bardalye 1982. Simultaneous
electron capture detection of chlorpyrifos and 3,5,6-trichloro-
2-pyridinol residue in peach and bahia grass field samples
following gel permeation cleanup. J.A.O.A.C. 65(2):210-214.
(From the open literature).
GS0100052 Hunt, L.M., B.N. Gilbert, and J.C. Schlinke. 1969. Rapid gas
chromatographic method for analysis of 0,0-<3iethyl 0-3,5-6-
trichloro-2-pyridyl phosphorothioate (Dursban) in turkey and
chicken tissues. J. Agric. Food Chem. 17(6):1166-1167.
Submitted under Section D of PPSF1306 (117943).
GS0100053 I.R.-4. 1980. Methods of determine chlorpyrifos and 3,5,6-
trichloro-2-pyridinol in fresh and spent mint hay and mint
oil. Conducted by U. Kiigemagi, R.D. Inman, and M.L. Deinzer
at Oregon State University. In Section D of PP#OE2372(099448).
GS0100054 Ivey, MC., and H.V. Claborn. 1968. Dursban oxygen analog:
Determination in fortified milk and body tissues of cattle.
J.A.O.A.C. 51(6):1245-1246. Submitted under Section D of
PPt3F1306 (117943).
GS0100055 Singh, J., and W.P. Cochrane. 1979. Confirmation of
organothiophosphorous insecticide residues in fruit and
vegetables by oxidative derivatization. J.A.O.A.C. 62(4):751-
756. (From the open literature).
GS0100056 Dow Chemical Co. 1973. Recovery of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol from bananas after storage in a freezer.
Submitted under PPf3F1370 (118172).
GS0100057 Dow Chemical Co. 1976. Recovery of 3,5,6-trichloro-3-pyridinol
fron fruit and nut samples fortified with chlorpyrifos or
3,5,6-trichlorc—2-pyridinol after prolonged storage at 0°F.
Submitted under PPI6F1777 (accession nunber unspecified).
GS0100058 Dow Chemical Co. 1973. Data tables entitled: "Recovery of
chlorpyrifos from crop substrates fortified with known amounts
of the compound following storage for various time intervals
at 0°F." and "Reanalysis of tissues from cattle for chlorpyrifos
following storage for various time intervals of 0°F." and
"Recovery of chlorpyrifos from milk fortified with known
amounts of the compound following storage at 0°F". Submitted
by Dow Chemical Co. in a letter to Edward Gross, RD, EPA, dated
May 21, 1973. Filed under PP#3F1306 (117945).
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GS0100059 Dow Chemical Co. 1976. Recovery of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol from fortified sweet potatoes after
storage in a freezer at 0°F. Table III Report No. GH-C 824.
Submitted under PP#6F1786 (undesignated accession number).
GS0100060 Dow Chemical Co. 1976. Recovery of chlorpyrifos and 3,5,6-
trichloro-2-pyrifinol from sorghum samples fortified with both
compunds and stored in a freezer at -18°C. Table III in Report
No. GH-C 900. Submitted under PP#6F1830 (undesignated accession
number).
GS0100061 Dow Chemical Co. 1978. Recovery of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol from tomato samples fortified with these
compounds and stored in a freezer at -18°C. Table III in
Report No. GH-C 829. Submitted under PP#8E2092 (097157).
GS0100062 Dow Chemical Co. 1979. Storage stability data tables III and IV
in Report No. GH-C 1107. Submitted under PPf9F2221/9H5227
(undesignated accession number).
GS0100063 Dow Chemical Co. 1979. Storage stability data table III in Report
No. GH-C 1041. Submitted under PPI9G2168/9H5204 (097781).
GS0100064 Dow Chemical stability data table III in Report No. GH-C 1209.
Submitted under PP#OF2281 (099038).
GS0100065 IR-4 Project. 1980. Data tables entitled: "Recovery of chlorpyrifos
from lOg samples of control onions spiked and stored 6 months
at -20°C. and "Recovery of 3,5,6-trichloro-2-pyridinol from
lOg samples of control onions spiked and stored 14 months at
-20°C." Submitted under PP#OE2387 (099507).
GS0100066 IR-4 Project. 1980. Storage stability data. Peppermint: fresh
hay, spent hay, and oil. Field investigators R.E. Berry and
Keith Pike. Submitted under PP#OE2372 (099448).
GS0100067 IR-4 Project. 1981. Data tables entitled: "Recovery of chlorpyrifos
from lOg samples of control cherries spiked and stored 8
months at -20°C." and "Recovery of 3,5,6-trichloro-2-pyridinol
from lOg samples of control cherries spiked and stored 15
months at -20°C." Submitted under PP#1E2529 (870135).
GS0100068 Dow Chemical Co. 1981. Stability of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol in whole tomatoes held in frozen storage.
Table V in Report No. GH-C 1282. Submitted under FAP#1H5295
(244590).
GS0100069 Dow Chemical Co. 1982. Recovery of 3,5,6-trichloro-2-pyridinol
from sugar beet roots and tops fortified with either chlorpyrifos
or 3,5,6-trichloro-2-pyridinol and stored in a freezer. Table
II in Report No. GH-C 1520. Submitted under PPf3H5352 (079855).
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-8-
GS0100070 Miller, P.W. 1982. Residues of chlorpyrifos and 3,5,6-trichloro-
2-pyridinol in walnuts treated with multiple foliar applications
of Lorsban insecticides. Table VI in Report No. GH-C 1579.
Submitted by Dow Chemical Co. under PPf3F27778.
GS0100071 IR-4 Project. 1978. Data tables entitled: "Residues of chlorpyrifos
and 3,5,6-trichloro-2-pyridinol (TCP) in radish: Analysis by
the Department of Agricultural Chemistry, Washington State
Univ." In Section D of PP8E2038(097442).
GS0100072 IR-4 Project. 1978. Data entitled: IR-4 Project 75. 020-Wells
and 020-Libby. In section D of PP#8E2038(097742).
GS0100073 IR-4 Project. 1978. Residues reports. Northeast Regional
Pesticide Laboratory. C. Eckenrode, investigator. Submitted
under PP#8E2038(097742).
GS0100074 IR-4 Project. 1978. Data table entitled: "IR-4 Project 75, 020-
Libby. Submitted under PP#8E2038 (097442).
GS0100075 Dow Chemical Co. 1976. Residues of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol in sugar beets and process fractions
treated with Lorsban insecticide. Report No. GH-C 729.
Submitted in Section D of PP#6F1745 (accession number unknown).
GS0100076 Dow Chemical Co. 1982. Residues of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol in sugar beets following multiple
applications of Lorsban insecticides. Submitted in Section D
of PP#2F2684/FAPf2H5352 (070855).
GS0100077 Dow Chemical Co. 1976. Residues of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol in sweet potatoes following pre-plant
application of Lorsban insecticides. Report No. GS-C 824.
J.H. Wetters and H.J. Dishburger, authors. Submitted under
PP#6F1786 (accession number unknown).
GS0100078 IR-4 Project. 1978. Residues of chlorpyrifos in turnip roots and
leaves: Analysis by the Department of Agricultural Chemistry,
Washington State University. Submitted under PH8E2038
(097442).
GS0100079 IR-4 Project. 1978. Data table entitled: IR-4 Project 75. 020-
Wells; Part 9 of 9. Submitted under PP#8E2038 (097442).
GS0100080 IR-4 Project. 1978. Residue reports: turnip root and turnip
leaves. Northeast Regional Pesticide Laboratory. C. Eckerode,
investigator. Submitted under PPf8E2038{097442).
GS0100081 IR-4 Project. 1980. Residue reports: turnip tops and turnip
roots. Submitted under PPIOE241K 099577).
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-9-
GS0100082 Dow Chemical Co. 1976. Residues of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol in sugar beets and processed fractions
treated with Lorsban insecticide. Report No. GH-C 729.
Submitted in Section D of PP#6F1745 (accession number unknown).
GS0100083 Dow Chemical Co. 1982. Residues of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol in sugar beets following multiple
applications of Lorsban insecticides. Report No. GH-C 1520.
Submitted in Section D of PP#2F2684/FAP 2H5352 (070855).
GS0100084 Dow Chemical Co. 1980. Section D PP#OE2387(099507).
GS0100085 IR-4 Project. 1977. Residue data for chlorpyrifos residues in or
on broccoli; from pages 18, 27, 28, 32, 76, 78, 81, 83, and
101. Submitted under section D of PP#7E2010.
GS0100086 IR-4 Project. 1977. Residue data for chlropyrifos residues in or
on brussels sprouts from pages 17, 22, 27, 31, 47, 49, 52, 54,
and 102. Submitted under Section D of PP#7E2010.
GS0100087 IR-4 Project. 1977. Residue data for chlorpyrifos residues in or
on cabbage; from pages 14, 16, 20, 21, 25, 26, 30, 56, 58, 60,
63, 64, 65, and 103. Submitted under Section D of PP#7E2010.
GS0100088 IR-4 Project. 1979. Chlorpyrifos residues on Chinese cabbage.
Pages 13, 23, 37, 46. submitted under Section D of PP#OE2412
(099578).
GS0100089 IR-4 Project. 1977. Residues of chlorpyrifos in or on cauliflower.
Pages 15, 19, 23, 29, 67, 69, 72, 74, and 104. Submitted under
Section D of PPI7E2010.
GS0100090 Dow Chemical Co. 1979. Tables 6-11, Section D. PP#9F2221
(accession no. unknown).
GS0100091 Dow Chemical Co. 1974. Tables 4-10, Section D.2. PP#4F1445
(118407).
GS0100092 Dow Chemical Co. 1974. Tables 4-9, Section D.3. PP#4F1445
(118407).
GS0100093 Dow Chemical Co. 1979. Tables 4-11, Section D. PP#9F2270
(070176).
GS0100094 Dow Chemical Co. 1981. Section B of PP#1E2523 (070087). [Used
only as a source for the label directions.]
GS0100095 Dow Chemical Co. 1978. Section B of PP#8E2092 (097157).
GS0100096 Dow Chemical Co. 1979. Data tables XI-XVII entitled "Residues of
chlorpyrifos and 3,5,6-trichloro-2-pyridinol in cucumbers
grown from seed treated with Lorsban insecticide." Report No.
GH-C 1159. Submitted under PP#9F2221/FAP#9H5227 (accession
number unknown).
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-10-
GS0100097 Dow Chemical Co. 1979. Data tables IV-X entitled "Residues of
chlorpyrifos and 3,5,6-trichloro-2-pyridinol in pumpkins grown
from seed treated with Lorsban insecticide." Report No. GH-C
1159. Submitted under PP#9F2221/FAP#9H5227 (accession number
unknown).
GS0100098 Dow Chemical Co. 1981. Residues data from Tables IX-XXIII in
Report GH-C 1441. Submitted under PP#1F2575 (070368).
GS0100099 Dow Chemical Co. 1979. Tables IV and V in Report GH-C 1041
entitled "Residues of chlorpyrifos and 3,5,6-trichloro-2-
pyridinol in whole oranges, peel plus pulp, and juice following
a foliar application with Lorsban 4E insecticide." Submitted
under PP#9G2168/FAP#9H5204.
GS0100100 Dow Chemical Co. 1979. Tables IV and V in Report GH-C 1141
entitled "Residues of chlorpyrifos and 3,5,6-trichloro-2-
pyridinol in whole oranges, peel, pulp, and juice following a
foliar application with Lorsban 4E insecticide." Submitted
under PPf9G2168/FAP#9H5204.
GS0100100 Dow Chemical Co. 1981. Section D. PP#6F1777 (accession no.
unknown).
GS0100101 Dow Chemical Co. 1981. Section D. PPflF2620 (070576).
GS0100102 Wetters, J.H. and H.J. Dishburger. 1975. Determination of residues
in fruits and nuts following dormant application of Lorsban
insecticide. Table Nos. XIII and XIV. Report No. GH-C 783
dated January 28 and submitted by Dow Chemical Co. under
PPt6F1777.
GS0100103 IR-4 Rutgers University. 1981. Section D of PP#1E2529 (870135).
GS0100104 Dishburgher, H.J., J.R. Rice, and J. Pennington. 1969. Determination
of residues of chlorpyrifos and its oxygen analog in peaches by
gas chromatography. Report No. TA-436R dated September 16 and
submitted by Dow Chemical Co. under PP#3F1306(117943).
GS0100105 McKellar, R.L., J.H. Wetters, and H.J. Dishburger. 1971. Residues
of chlorpyrifos, its oxygen analog, and 3,5,6-trichloro-2-
pyridinol in peaches following trunk or foliar applications of
Dursban insecticide. Table Nos. III-IV. Report No. GH-C 479
dated September 29 and submitted by Dow Chemical Co. under
PPf3F13Q6(117943).
GS0100106 Wetters, J.H. and H.J. Dishburger. 1975. Determination of residues
in fruits and nuts following dormant application of Lorsban
insecticide. Table Nos. XV-XX. Report No. GS-C 783 dated
January 28 and submitted by Dow Chemical Co. under PPf6F1777.
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-11-
GS0100107 Wetters, J.H and H.J. Dishburger. 1975. Determination of residues
in fruits and nuts following dormant application of Lorsban
insecticide. Table Nos. XXV-XXXI. Report No. GH-C 783 dated
January 28 and submitted by Dow Chemical Co. under PPI6F1777.
GS0100108 IR-4 Rutgers University. 1982. Residue data sheets. Section D.
PP#2E2682 (070847).
GS0100109 IR-4 Rutgers University. 1982. Residue data sheets. Section D.
PPI2E2584 (070720).
GS0100110 IR-4 Northeast Regional Laboratory. 1980. Residue data sheets.
Section D PP*OE2283 (099605).
GS0100111 Miller, P.W., 1982. Residues of chlorpyrifos and 3,5,6-trichloro-
2-pyridinol in almonds received multiple foliar applications
of Lorsban insecticides. Report No. GH-C 1530 submitted by
Dow Chemical Co. under PPI3F2778.
GS0100112 Miller, P.W. 1982. Residues of chlorpyrifos and 3,5,6-trichloro-
2-pyridinol in walnuts receiving multiple foliar applications
of Lorsban insecticides. Report No. GH-C 1579 submitted by
Dow Chemical Co. undr PP#3F2778.
GS0100113 Dow Chemical Co. 1973. Data tables III-VIII entitled "Residues
of chlorpyrifos and 3,5,6-trichloro-2-pyridinol in green corn
forage, grain and stover following application of Dursban
insecticide at planting" in Report No. GH-C 530. Submitted
under PPt3F1306 (117943).
GS0100114 Dow Chemical Co. 1974. Determination of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol in green plants, kernels, kernels and
cobs, cobs and husks, and husks of sweet corn grown from seed
treated with Lorsban insecticide. Report No. GH-C 664.
Submitted under PP#4F1445 (118404).
GS0100115 Dow Chemical Co. 1981. Residues of chlorpyrifos and 3,5,6-trichlor-
2-pyridinol in field corn following multiple applications of
Lorsban insecticides. Report No. GH-C 1440. Submitted under
PP#1F2544 (070208).
GS0100116 Dow Chemical Co. 1981. Residues of chlorpyrifos and 3,5,6-
trichloro-2-pyridinol in corn process fractions following
treatement of grain with Lorsban 4E insecticide. Report No.
GH-C 1465. Submitted under PPI1F2544 (070208).
GS0100117 Dow Chemical Co. 1976. Report No. GH-C 900: Residues of chlor-
pyrifos and 3,5,6-trichloro-2-pyridinol in sorghum green
plant, silage, dry plant, and grain following multiple
applications with Lorsban insecticide. Submitted under
PP#6F1830.
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GSO100118 Dow Chemical Co. 1978. Report No. GH-C 1109: Residues of
chlorpyrifos and 3,5,6-trichloro-2-pyridinol in grain and
milling fractions following multiple applications of Lorsban
4E insecticide to sorghun. Submitted under PPf6F1830 (097128).
GS0100119 Dow Chemical Co. 1976. Report No. GH-C 900: Residues of chlor-
pyrifos and 3,5,6-trichloro-2-pyridinol in sorghum green
plant, silage, dry plant, and grain following multiple
applications with Lorsban insecticide. Submitted under
PPf6F1830.
GS0100120 Wetters, J.H., E.J. Norton, and T.K. Jeffries. 1979. Residues of
chlorpyrifos and 3,5,6-trichloro-2-pyridinol in alfalfa green
forage and hay following foliar applications of Lorsban 4E
insecticide, (report no. GH-C 1209). Submitted by Dow Chemical
Co. under PPSOF2281 (099038).
GS0100121 Dow Chemical Co. 1973. Section D of PP#3F1370 (118172).
GS0100122 McKellar, R.L. and Dishburger, H.J. 1974. Determination of
residues of chlorpyrifos and 3,5,6-trichloro-2-pyridinol in
cottonseed and gin trash following multiple treatments of
cotton plants with Lorsban insecticide. Submitted by Dow
Chemical Co. under PP#6F1673.
GS0100123 McKellar, R.L. and Dishburger, H.J. 1975. Determination of
residues of chlorpyrifos and 3,5,6-trichloro-2-pyridinol in
cottonseed, gin trash and process fractions following multiple
treatments of cotton plants-with Lorsban insecticide. Submitted
by Dow Chemical Co. under PP#5G1595 (119148).
GS0100124 McKellar, R.L. 1975. Determination of residues of chlorpyrifos
and 3,5,6-trichloro-2-pyridinol in cottonseed, gin trash and
process fractions following multiple treatments of cotton
plants with Lorsban insecticide. Submitted by Dow Chemical
Co. under PP#6F1673.
GS0100125 IR-4 Project. 1981. Submitted under PPt2E2668 (070783) pages
13-43.
GS0100126 Dow Chemical Co. 1983. Tables 3439E, 3439F, 4903I/I, 4903II/E,
4903II/G, 5470D in section of PPI3E2766 (071167).
GS0100127 IR-4 Rutgers University. 1980. Residue data sheets. Section D.
PPfOE2372 (099448).
GS0100128 Miller, P.W. 1980. Residues of chlorpyrifos and 3,5,6-trichloro-
2-pyridinol in peanut oil fractions. Report No. GH-C 1278
submitted by Dow Chemical Co. under PP#9F2193/9H5226 (099201).
-------
-13-
GS0100129 Miller, P.W. 1979. Residues of chlorpyrifos and 3,5,6-trichloro-
2-pyridinol in or on peanuts receiving one or two applications
of Lorsban insecticides. Report No. GH-C 1173 sutmitted by
Dow Chemical Co. under PPI9F2193 (09038).
GS0100130 Miller, P.W. 1979. Residues of chlorpyrifos and 3,5,6-trichloro-
2-pyridinol in peanut fractions. Report No. GH-C 1199 submitted
by Dow Chemical Co. under PPI9F2193 (098335).
GS0100131 Miller, P.W. and O.K. Ervick. 1978. Residues of chlorpyrifos
and 3,5,6-trichloro-2-pyridinol in or on peanuts receiving
multiple applications of Lorsban insecticides. Report No.
GH-C 1071 submitted by Dow Chemical Co. under PP#9F2193 (09038).
GS0100132 Dow Chardcal Co. 1982. Section D. PPS2F2588 (070408).
GS0100133 Astill, K.J. of Dow Chemical (Australia). Letter dated October 23,
1968 to Dr. D.R. Casorso of Dow Chemical, Midland, MI.
Submitted by Dow Chemical Co. under PP#3F1306 (117942).
GS0100134 Claborn, H.V., R.A. Hoffman, H.D. Mann, and D.D. Oehler. 1968.
Residues of Dursban and its oxygen analog in the .body tissues
of treated cattle. J. Econ. Entcmol. 61(4):983-986. Submitted
by Dow Chemical Co. under PPI3F1306 (117942).
GS0100135 Claborn, H.V., U.S.D.A., A.R.S., Entomology Research Division,
Kerrville, IX. 1970. Report No. PCK 70-1: Report of residue
analysis. Prepared for and submitted by Dow Chemical Co.
under PP#3F1306 (117943).
GS0100136 Department of Primary Industries, Queensland, Australia. Letter
dated April 22, 1969, to Mr. K.J. Astill of Dow Chemical
(Australia). Submitted under PP#3F1306 (117942).
GS0100137 Dishburger, H.J., R.L. McKellar, J.Y. Pennington, and J.R. Rice.
1977. Determination of residues of chlorpyrifos, its oxygen
analogue, and 3,5,6-trichloro-2-pyridinol in tissues of cattle
fed chlorpyrifos. J. Agric. Food Chem. 25(6)-.1325-1329.
GS0100138 Dow Chemical Co. 1966. Report No. TA-336: The effect of
formulation on Dursban residues in omental fat of cattle
following single spray application. Submitted under PP#3F1306
(117942).
GS0100139 Dow Chemical Co. 1967. Report No. TA-372: Dursban residues in
the omental fat of cattle following two dip applications.
Submitted under PP#3F1306 (117942).
GS0100140 Dow Chemical Co. 1971. Residues of 3,5,6-trichloro-2-pyridinol
in tissues from cattle following multi-dip applications in a
vat charged with Dursban insecticide. Submitted under
PP#3F1306 (117943).
-------
-14-
GS0100141 Dow Chemical Co. 1972. Report No. GH-C 549: Residues of
chloropyrifos and 3,5,6-trichloro-2-pyridinol in tissues of
swine fed chloropyrifos. Submitted under PP#3F1306 (117943).
GS0100142 Dow Chemical Co. 1972. Report No. GH-C 566: Determination of
residues of chloropyrifos its oxygen analog and 3,5,6-trichloro-
2-pyridinol in tissues of cattle fed chloropyrifos. Submitted
under PP#3F1306 (117943).
GS0100143 Dow Chemical Co. 1976. Report No. GH-C 930: Determination of
residues of chloropyrifos and 3,5,6-trichloro-2-pyridinol in
tissues of cattle receiving a single treatment of Dursban Spoton.
Submitted under Ace. No. 226146.
GS0100144 Ivey, M.C. 1979. Chlorpyrifos and 3,5,6-trichloro-2-pyridinol:
residues in the body tissues of cattle wearing chlorpyrifos-
impregnated plastic ear tags. J. Econ. Entomol. 72:909-911.
GS0100145 Ivey, M.C. and J.S. Palmer. 1979. Chlorpyrifos and 3,5,6-
tnchloro-2-pyridinol: residues in body tissues of swine
treated with Chlorpyrifos for hog louse and itch mite control.
J. Econ. Entonol. 72:837-838.
GS0100146 Ivey, M.C. and J.S. Palmer. 1981. Chlorpyrifos and 3,5,6-
trichloro-2-pyridinol: residues in the body tissues of sneep
treated with Chlorpyrifos for sheep ked control. J. Econ.
Entomol. 74:136-137.
GS9100147 Mann, H.D. Pesticide Chemical Research Branch, Entomology Research
Division, A.R.S., U.S.D.A. 1966. Report No. PCK-66-2: Report
of Dursban insecticide residue analysis in treated cattle.
Prepared for and submitted by Dow Chemical Co. under PP#3F1306
(117942).
GS9100148 Bowman, M.C., U.S.D.A., A.R.S., Entomology Research Division, GA.
1967. Report No. PCT 67-4: Report of residue analysis.
Submitted by Dow Chemical Co. under PPI3F1306 (117946).
GS0100149 Dow Chemical Co. 1972. Report No. GH-C 533: Residues of
chloropyrifos, its oxygen analog, and 3,5,6-trichloro-2-
pyridinol in milk and cream from cows fed chloropyrifos.
Submitted under PP#3F1306 (117946).
GS0100150 Johnson, J.C., Jr., M.C. Bowman, and D.B. Leuck. 1969. Responses
from cows fed silages containing Dursban residues. J. Dairy
Science 52(8):1253-1258. Submitted by Dow Chemical Co. under
PP13F1306 (117946).
GS0100151 McKellar, R.L., H.J. Dishburger, J.R. Rice, L.F. Craig and J.
Pennington. 1976. Residues of chlorpyritos, its oxygen
analogue, and 3,5,6-trichloro-2-pyridinol in milk and cream
from cows fed Chlorpyrifos. J. Agric. Food Chem. 24(2):283-286.
-------
-15-
GS0100152 Claborn, H.V., U.S.D.A., A.R.S., Entomology Research Division.
1968. Report No. PCK-68-4: Report of residue analysis.
Submitted by Dow Chemical Co. under PP#9G0817 (116009).
GS0100153 Claborn, H.V., S.E. Kunz, and H.D. Mann. 1970. Residues of
Dursban in the body tissues of turkeys confined in pens
containing treated soil. J. Econ. Entomol. 63(2):422-424.
Submitted by Dow Chemical Co. under PP#3F1306 (117942).
GS0100154 Dishburger, H.J., J.R. Rice, W.S. McGregor and Joan Pehnington.
1969. Residues of Dursban insecticide in tissues from turkeys
confined on soil treated for chigger control. J. Econ.
Entomol. 62(1):181-183. Submitted by Dow Chemical Co. under
PP#3F1306 (117942).
GS0100155 Dow Chemical Co. 1968. Manuscript for Econ. Entomol. entitled
"Residues of Dursban in tissues from turkeys confined on soil
treated for chigyer control." Submitted under PPff9G0817 (116009)
GS0100156 Dow Chemical Co. 1972. Report No. GH-C 555: Residues of
chlorpyrifos and 3,5,6-trichloro-2-pyridinol in tissues and
eggs from chickens fed chlorpyrifos. Submitted under PP#3F1306
(117946).
GS0100157 Ivey, M.C., U.S.D.A., Entomology Research Div., Kerrville, TX.
1971. Report No. PCK-71-1: Report of residue analysis.
Prepared for and submitted by Dow Chemical Co. under PP#3F1306
(117942).
GS0100158 Bio/dynamics, Inc. 1976. Professional roach tape containing
Dursban-food air residue test. Prepared for and submitted by
Herculite Protective Fabrics Corp. under PP#6H5147.
GS0100159 Dow Chemical Co. 1973. Report No. GH-C 678: Residue study:
Determination of chlorpyrifos in food from food handling
establishments treated with Dursban insecticide. Submitted
under PP#5H5080.
GS0100160 Dow Chemical Co. 1974. Report No. GH-C 773R: Residue study:
Determination of chlorpyrifos in human food resulting from
treatment of food handling establishments with Dursban 2E
insecticide. Submitted under PP#5H5080.
GS0100161 Herculite Protective Fabrics Corp. 1975. Report NO. 75-18:
Release rate of chlorpyrifos from hercon "Roach-tape" at
temperatures of 40-50°F, 70-80°F, 95°F and 120°F. Submitted
under PP#6H5147 (232815).
GS0100162 Positive Formulators, Inc. 1977. Report: Food residue data on
Killmaster II in support of a petition for its use in food
areas of food handling establishments. Submitted under
PP#7H5172 (231274).
-------
-16-
GS-0100163 Ware, G.W., and W.P. Cahill. 1977. Air concentrations of
chlorpyrifos (Dursban) from a 2% slow-release paint-on
formulation vs. a standard 0.5% emulsion spray. Submitted to
the Bull. Environ. Contain. Toxicol. on July 21, 1977. Submitted
by Positive Formulators, Inc. under PP#7H5172 (231274).
GS-0100200 Coulston, F. Goldberg, L. and T. Griffin. 1972. Safety evaluation
of DOWCO 179 in humans volunteers. Inst. EXP. Path. Tbx.,
Albany Medical College, Albany, N.Y. (unpublished report).
GS-0100201 Kawachi, T. 1978. Technical development of screening carcinogens
having mutagenicity. Annual Report of the National Cancer
Center of Japan.
GS-0100202 Ouelette, J. H., Dittenber, D. A., Kloes, P. M. and J. A. John.
1983. Chlorpyrifos: Two-Generation reproduction study in Fischar
rats. Dow Chemical Co. (Unpublished).
GS-0100203 Deacon, M. M., Murray, J. S., Pilney, M. K., Dittenber, D. A.,
Hanley T. R., and J. A. John. 1979. The effects of orally admin-
istered chlorpyrifos on embryonal and fetal development in mice.
Dow Chemical Co. (Unpublished).
GS-0100204 Ouelette, J. H., Dittenber, D. A., Kloes, P. M. and J. A. John.
1983. Chlorpyrifos: Oral teratology study in Fischer 344 rats.
Dow Chemical Co. (Unpublished).
GS-0100206 Food and Agricultural Organization of the United Nations.
Pesticides Residues in Food: 1982 Evaluations.
1983.
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Chlorpyrifos Standard
00025619 Bidlack, H.D. (1979) Degradation of Chlorpyrifos in Soil under
Aerobic, Aerobic/Anaerobic and Anaerobic Conditions. Method
GH-C 1258 dated Nov 29, 1979. (Unpublished study received
Dec 19, 1979 under 464-448; submitted by Dow Chemical U.S.A.,
Midland, Mich.; CDL:241547-A)
00028464 Coulston, F.; Griffin, T.B. (1975) A Safety Evaluation of Dowco
214 in Rats and Rhesus Monkeys. (Unpublished study received
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00029063 McCollister, S.B.; Kociba, R.J.; Gehring, P.J.; et al. (1971)
Results of Two-Year Dietary Feeding Studies on DOWCO 179 in
Beagle Dogs. (Unpublished study received Aug 28, 1972 under
3F1306; submitted by Dow Chemical U.S.A., Midland, Mich.;
CDL: 099239-A)
00030504 McKellar, R.L. (1980) Determination of Chlorpyrifos and 3,5,6-
Trichloro-2-pyridinol in Green and Cured Tobacco Grown in
Soil Treated with Lorsban Insecticides. (Unpublished study
received Feb 20, 1980 under 464-448; submitted by Dow Chemical
U.S.A., Midland, Mich.; CDL:241848-A)
00040602 Johansen, C.; Mayer, D.; Baird, C. (1973) Bee Research Investiga-
tions, 1973. (Incomplete, unpublished study received Oct 21,
1976 under 6F1696; prepared by Washington State Univ., Dept.
of Entomology in cooperation with Alfalfa Seed Pest Management
Project, submitted by E.I. du Pont de Nemours & Co., Inc.,
Wilmington, Del.; CDL:095326-M)
00043244 Coulston, F.; Golberg, L.; Abraham, R.; et al. (1971) Final Report
on Safety Evaluation and Metabolic Studies on Dowco 179 (in
151). (Unpublished study received Sep 18, 1980 under 464-557;
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Pathology and Toxicology, submitted by Dow Chemical U.S.A.,
Midland, Mich.; CDL:099643-B)
00043657 Mitchell, A.D. (1975) Unscheduled DNA synthesis testing of substi-
tute pesticides. Pages 151-153, in Substitute Chemical Pro-
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Symposium; Jul 30-Aug 1, 1975, Washington, D.C.: U.S.
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-------
00046543 Henck, J.W.; New, M.A.; JOHNSON, K.A. (1980) Chlorpyrifos concen-
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pyrifos and its oxygen analogue in field-treated wheat plants.
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00046951 Fink, R.-; Beavers, J.B.; Brown, R. (1978) Final Report: One-
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00046952 Fink, R.; Beavers, J.B.; Brown, R. (1978) Final Report: One-Genera-
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dietary LC50—mallard duck: project no. 103-180. (unpublished
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00046955 Fink, R.; Beavers, J.B.; Brown, R. (1978) Final Report: Eight-Day
Dietary LC50—Bobwhite Quail: Project No. 103-179. (Unpublished
study received Oct 15, 1980 under 464-448; prepared by Wildlife
International, Ltd. and Washington College, submitted by Dow
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00051592 Bischoff, R.F. (1976) Letter sent to M.L. Wulf dated Jun 2, 1976
Solubility characteristics of ruelene R. (unpublished study
received Jun 21, 1976 under 464-512; submitted by Dow Chemical
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00054352 Warner, S.D.; Gerbig, C.G.; Strebing, R.J.; et al. (1980) Results
of a Two-Year Toxicity and Oncogenic Study of Chlorpyrifos Ad-
ministered to CD-I Mice in the Diet. (Unpublished study re-
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-------
00056603 U.S. Fish and Wildlife Service (1968) Effects of Pesticides:
Pesticide Monitoring. Quarterly rept., Jan 1, 1968—Mar 31,
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00064934 Thompson, D.J.; Gerbig, C.G.; Warner, S.D. (1971) Three Generation
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00064935 Stevenson, G.T. (1966) A Neurotoxicity Study of Dursban in Laying
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092213-C)
00066220 Atkins, E.L., Jr.; Anderson, L.D.; Kellum, D.; et al. (1976)
Protecting Honey Bees from Pesticides. ?: Univ. of California,
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00080022 Carreon, R.E.; Kociba, R.J.; Keyes, D.G.; et al. (1981) Chlorpy-
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00095007
-------
00095114 Kenaga, E.E. (1968) Simulated Wildlife-environmental Effects with
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00095128 Miller, W.O. (1966) Pond Treatment with Dursban For Bluegill Sun-
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00095250 Rowe, L.D.; Warner, S.D.; Johnston, R.V. (1978) Acute Delayed Neu-
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-------
00095305 Shellenberger, T.E. (1971) Letter sent to Eugene E. Kanaga
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-------
00095446 Kenaga, E.E.; Fink, R.J.; Beavers, J.B. (1978) Dietary Toxicity
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study received Jan 29, 1979 under 464-343; prepared oy Wildlife
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Chemical U.S.A., Midland, Mich.; CDL:236884-C)
00095449 Fink, R.; Beavers, J.B.; Brown, R. (1978) Final Report: Eleven-
day Toxicant 1 X LC50, with Five-day Half-life, Decreasing
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184. (Unpublished study received Jan 29, 1979 under 464-343;
prepared by Wildlife International, Ltd., and Washington Col-
lege, submitted by Dow Chemical U.S.A., Midland, Mich.; CDL:
236884-D)
00095450 Fink, R.; Beavers, J.B.; Brown, R. (1978) Final Report: Eleven-
day Toxicant 2 X LC50, with Five-day Half-life, Decreasing
Concentrations—Mallard Duck: Chlorpyrifos: Project No. 103-
183. (Unpublished study received Jan 29, 1979 under 464-343;
prepared by Wildlife International, Ltd., and Washington Col-
lege, submitted by Dow Chemical U.S.A., Midland, Mich.; CDL:
236884-E)
00102520 McCarty, W.M. (1977) Toxicity of Chlorpyrifos to Daphnids: Report
ES-164. (Unpublished study received Feb 13, 1978 under 464-363;
submitted by Dow Chemical U.S.A., Midland, Mich.; CDL:232910-A)
00102758 Hansen, D. (1969) Avoidance of pesticides by untrained sheepshead
minnows. Trans. Amer. Fish. Soc. 98(3):426-429. (Also in un-
published submission received Jan 5, 1972 under 2E1221; sub-
mitted by U.S. Dept. of the Army, Washington, DC; CDL:097882-X)
00104696 Miller, W.O. (1966) The Effects of an Aerial Application of Dursban
on the Fauna on a Coastal Island and in Associated Marsh Areas.
(Unpublished study received Apr 29, 1968 under 464-368; sub-
mitted by Dow Chemical U.S.A., Midland, Mich.; CDL:003574-D)
-------
05000838
05001991
05004861
05010438
Mulla, M.S.; Norland, R.L.; Westlake, W.E.; Dell, B.; St. Amant,
J. (1973) Aquatic midge larvicides, their efficacy and residues
in water, soil, and fish in a warm-water lake. Environmental
Entomology 2(l):58-65.
Stevenson, J.H. (1978) The acute toxicity of unformulated
pesticides to worker honey bees (Apis mellifera:L). Plant
Pathology 27(1):38-40.
Poole, D.C.; Siimon, V.F.; Newell, G.W. (1977) In vitro mutagenic
activity of fourteen pesticides. Toxicology and Applied
Pharmacology 41(1):196.
Sintnon, V.F.; Poole, D.C.; Newell, G.W. (1976) In vitro mutagenic
studies of twenty pesticides abstract no 42. Toxicology and
Applied Pharmacology 37(1):109.
-------
APPENDIX II-2
OMB Approval No. 20004468 (Expint 12-31-83)
FIFRA SECTION 3(C)(2)(B) SUMMARY SHEET
EPA REGISTRATION NO.
PRODUCT NAME
APPLICANTS NAME
DATE GUIDANCE DOCUMENT ISSUED
With respect to the requirement to submit "generic" data impond by the FIFRA action 3(C)(2)(B) notics contained in the referenced
Guidance Document, I am responding in tha following manner
O 1. I will submit data in a timely manner to satisfy tha following requirements. If the fast procedures I will use deviate from (or are not
specified in) the Registration Guidelines or the Protocols contained in the Reports of Expert Groups to the Chemicals Group, OECD
Chemicals Testing Programme, I enclose the protocols that I will use:
O 2. I have entered into an agreement with one or more other registrants under FIFRA section 3(C)(2)(B)(ii) to satisfy the following data
requirements. The lasts, and any required protocols, will be submitted to EPA by:
NAME OF OTHER REGISTRANT
D 3. I enclose e completed "Certification of Attempt to Enter Into an Agreement with Other Registrants for Development of Data" with
respect to the following data requirements:
D 4. I request that you amend my registration by deleting the following uses (this option is not available to applicants for new products):
O 5. 1 request voluntary cancellation of the registration of this product. (This option is not available to applicants for new productsJ
REGISTRANTS AUTHORIZED REPRESENTATIVE
SIGNATURE
DATE
EPA Form 8580-1 (10-82)
-------
APPENDIX H-3
OMB Approval No. 200O4468 fExpires: 12-31-S3)
(To otm/ify, certify ALL four rtvnt)
CERTIFICATION OF ATTEMPT TO ENTER
INTO AN AGREEMENT WITH OTHER REGISTRANTS
FOR DEVELOPMENT OF DATA
1. I am duly authorized to represent the following firm(s) who are subject to the require-
ments of • Notice under FIFRA Section 3(c)(2){B) contained in a Guidance Document
to submit data concerning the active ingredient:
GUIDANCE DOCUA
ACTIVE INGREDIENT
NAME OF FIRM
EPA COMPANY NUMBER
(This firm of group of firmi is referred to below as "my firm".)
2. My firm is willing to develop and submit the data as required by that Notice, if necessary. However, my firm would prefer to enter
into an agreement with one or more other registrants to develop jointly, or to share in toe cost of developing, the following required
items or data:
3. My firm has offend In writing to emar into such an agreement. Copies of tha offers art attached. That offer was irrevocable and included an offer to b«
bound by an arbitration decision under FIFHA Section 3 ff final agreement on all arms could not be reached otherwise. This offer was made
to me following firm(s) on the following data(s):
NAME OF FIRM
DATE OF OFFER
wed my offer.
jujJUfcrei, itvfic w> mvaey iinmj|^»»'^^M*«*j^^j^^^j^^^,^^^^M_^^^MM_i^^^^.^^^^_M^,,^^M«M^MIBBM^^^^»»^M- _^_—.—_^^_——^—
4 My firm requests that EPA not suspend the registration(s) of my firm's product(s). rf any of the firms named in paragraph (3) above
have agreed to submit the data listed in paragraph (2) above in accordance with the Notice I understand EPA will promptly-infonn
me whether my firm must submit data to avoid'suspension of its registrations) under FIFRA Section 3(c)(2){B). (This statement
does not apply to applicants for new products.) I give EPA permission to disclose this statement upon request.
TYPED NAME
SIGNATURE
DATE
EPA Form 868O4 <10-82)
-------
Appendix III-l
PRODUCT SPECIFIC DATA REPORT
EPA Registration No. Guidance Document for_
Date
Registration
Guideline No.
§158.20
PRODUCT
CHEMISTRY
61-1
61-2
61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-9
63-10
63-11
63-12
63-13
6>T4
63-15
-
£-> 1 (.
DJ J.D
fi^-17 ~"
63-18
Name of Test
Identity of
ingredients
Statement of
composition
Discussion of
formation of
ingredients
Preliminary
analysis
Certification of
limits
Analytical methods
for enforcement
limits
Color
Physical state
Odor
Melting point
Boiling point
Density, bulk-
density, or
specific gravity
Solubility
Vapor pressure
Dissociation
constant
Octanol/water
partition
coefficient
pH
Stability
Oxidi zing/reducing
reaction
Flammability
Explodability
Storage stability
Viscosity
Test not
required
for my
product
listed
above
(check
below)
I am complying with
data requirements by
Citing MRID#
or
"GS"#
Submit-
ting
Data
(At-
tached)
For EPA Use Only)
Accession Numbers
Assigned
-------
63-19
63-20
63-21
§158.135
TOXICOLOGY
81-1
81-2
81-3
81-4
81-5
81-6
Miscibility
Corrosion
characteristics
Dielectric break-
down voltage
Acute oral LD-50,
rat
Acute dermal
LD-50
Acute inhalation,
LC-50 rat
Primary eye
irritation, rabbit
Primary dermal
irritation
Dermal sensitiza-
tion
-------
APPENDIX 17-1
flttlT
set in: type of the same mtnim,m n^^
jerrequired for the child hazard warn-
tncKXhxlXiv).j
CO Any limitations or restrictions art
use* required to prevent unreasonable
(A3 Require* tnterrml*- between: an-
gncirton and harwst o£ food or feed;
-ni;«fty labeled according- to the la-
beunc standards- set fortis Irt this sub*
beyond those purposes and. uses con-
tained in the Directions for Use win be
considered a false, or
nient under the statutory dmti-nitin^g.
(2) lUatrictfd. Us* Classification.
Pesticide products- bearing- direction-
for usetsj classified restricted-
bear statements of restricted- us*
~' " front panel aav de>
(ii
pon«£
rtatrict-
At the top of
ta« front panel of the label, set in type-
of the same cainimum sizes as requir-d
for human, hazard .tignai wort, (sea,
table in i 162OO and general. use
-------
f
lluiui M> »vo|a potent^) accident.
Injury or damage. Baamplea of the
hazard atatemenU and (lie clrouw
atancea under which they »re required
follow:
(A) II ft peatlctde Intended lor out-
door MHO contain* an ectiv* Ingredient
wllh a mammalian acute 0ia| JJ)M of
100 or lea*. the atatement "TrtU pwU-
clde laTo«lo to Wildlife" U required/
([)) II • peatlclde Intended for out-
door uae corilalna an active Ingredient,
with a lUh acute !<(«. of I ppm or |eaa. *
the elatemeiil "ThU featlolde U To»|o
to Hah" la required.
(C) If « peatlclde Intended for out-
door uae conlalna en nelly* Ingredient
with an ayian acute oral IJ)M of 104
mg/k « or tew. or • aubacuie dietary
IUctt«* if
(P) I( cither accident hUtory or field
ttudlea demofkaUate tha| uae. of the,
peatlcfde (nay r«u|t In fatality M»
blrde, f|a|) or nien»r»ala. the abatement
Vor all outdoor iuaf other Mian
aquatic application* the label fuiut
bear the caution "Keep put of |akea,
poiuit or atreauu. Po rutt contani|itale
water by cleaning o,f euulpinent or dia- .
po«al of waate*."
(Ill) f/iyiical or cAcmloal Aa«ar«iff
. CunnnU untai yr*M»*. On ml kM « M>« fM« hMl
• 0»»4 --' -'- • • •-•-.-•--
M « IMIM W f _......„_.-
Atioo* W f Mil K» <»-«l •«• f
Afaw* M- f Mrf MM 0^1 (W f
Nm»MUu«u«» COMI
. pa M WH « »»•
/or
J—(I) Jrf«auaay and clar-
ify a/ 4!r«oi|on«. Dlraotion* for uae
iniittt be nl»led In t'rnu whfo|i can be
easily road arid undoratood by the
average peraon likely to u»e or to au-
pervUe llio ua« of the poatlclde. When
followed, dlreclloita rnuat be adequate
to protect the publlo from fraud and
from personal Injury and |o prevent
pnreaaonable adyerae cftecta on the
envlrunment.
(l|) Placement t*t illrecUoit* /or uie.
Ujrcctlofui may appear on any portion.
of the label provided that they art
conaplcuoua enough to be eaally rea^
by th« u«er of the ucatlclde product-
Plrectloiu) for uae piay appear M
printed or graphic matter which a*
companlea the peat|clde provided M"^
"
clde. or placed, w|lhlri thp «wUW«
wrapper or bag;
(») The label beara a (oteiti** I*
the direction* for uae In accompanylM
lealleU or cliculara. »ucli aa "Qct •*
recllona In M>
APPENDIX IV-1
(continued)
C|««rly
\ IM-IQ
that the
" In
"
f * '"*™T|T*W» Mil JIIIlM.
• >i. • ;•' 'or u*° M » P««Uclde and
i Bssyfe1"1*""*1*"*
»uc||
data ahceta mr bulleM/u.
•vallable to Ihp trade apeclfylng
»yf» Pf product Involtred and
proper u*e In wanufad
the heading "Storaga
*"''• heading muat be
-------
xv-i
Jill*
f wykf iw»t r»|
thotie required on Hie front panel of
(lie labeling and thoae w|i|c|i n»ay
appear elaewhere. 8peo|f|o require
menta concerning content, placement,
type alze. and pronu'nence are given
below.
(1) JUqutred front panel ttafemciit*.
the exception of ||ie child
hazard warning atateruenl. the text re-
quired on the front P*ne| of the >«M
la determined by the Toxlcjly Catego-
ry of the peatlclde. The category U aa-
algned on the baala of the hlgheat
hazard ahown hy any o| the Indicator*
in the l*l"« below;
I
' I
Onito.
f,o«MpulMpa/»4
UP fe MM *v*M*y j fiont jt«i|M9/*«....
f«o* MO «*» M0» f|u«».OOg^W.Ooa.. OlMMf f Mi) M.MO,
&•
COHCM^M. caiitM
(IU4
ItwUil* ***i |
Mo un
6AM tHtctt
(|) Human
•faijcHi/ Category |. All peJtt|clda prod-
ucU meeting the criteria of Toxlclty
Category I «hal) bear on the fron^
panel the signal word "Danger." In ad-
dition U the product wa» assigned to
Toxlclty Category \ on the baab of |U
oral. Inhalation or dermal toxlclty (M
dUllnct (rom akin and eye loca) cf-
fecU) the word " Poison" ihall appear
In red on a bacHground of distinctly
contracting color and M>e »ku|l and.
croiuboncn «hall appear In ImnteOlale
proximity to the word "politon."
(U) rtiilcUv Category II, Al\
cMe product* meeting the criteria of
Toxlclty Category U ahal| bear on the
front uane) the nlgnal word "Warn-
ing."
(C) Toxicitv Cateaom ///. All pe«tl-
ctde producU meeting the criteria of
Toxlclty Category lU ah»l| bear OH
the front pane) the algna| word. ''C*H-
(D> Toxicllv Category IV- All
cldo producU meeting the criteria of
Toxlclty Category IV ahall bear on the
front panel the nlgnal word "Caution."
I IK} V»e oJ «nal wortl*. Uae of any
Ignal word
that It |a approved for ua* on InfanM
or amall children, may the AdmlnUUa-
\pt waive thla reaulrement.
(Ill) Statement oj practical <"«<-
ineiU—(A) Toxicttv Category I- *
•tateinent of practical treatment «'•«
aid or other) ahall appear on the front
panel of the label of all peatlcldoa UU
Ing Into Toalclty Category I oil thf
baala of oral. Inhalation or dermal to*-
|clty. The Agency may. how««'-
permit reasonable yarlatloiui In »'«
placement of the alatenienl of pract^
ca) treatment U aome reference auci»
aa "Bee atatement of practical If"*'
merit Pn bacli panel" appear^ o« »i»f
(continued)
(— pqylr«r»w«n|«<
|0
panel near the word 'ToUon"
and the akul) and crofi^ponea.
(D) Other (ojt{city cutcaorUt. The
ftateiuenl pf practical treatment la not.
rewired on Hie front panel except aa
deacrlbed III paragraph (hKlHlUKA) of
||iU section. The applicant may. how-
ever, Include auch a front pane) «ute-
mt>nt »t hla pptloi>. Statement! of
practical |reatmei4 are, however, re-
Quired elaewherp on the |abe| |n
accord wUh paragraph (hMl) of (hla
•^M°0 l( Mi«y da nof appear PI» t|to
front panel.
<|y) flactwei\t «»»<| pwtMnence. All
|he require front panel warning atate-
inenM ahall he grouped, together t»\
the |abe|. and ahall appear wl|h auffl-
clciit proiu|neitc« relative tft other
front P»nel text and graphic material
to make then) unlikely |o be oy«sr-
looked under cualomaty conomona of
purchaae and uae. T|»e following table
4howa tlie mui|muni type a|x« require-
(or the front pane) warning
\ varloua *\u* pf
&**•«"
Aiiov* l« to 14..
AuJ«|.k,M..
II
M
I*
l»
II
. The warnlnga
and precautionary atatemenM aa re
quired below «ltal| appear together on
the label under the general heading
"Precautionary Staiemeala" and
under appropriate aubhfdlnga of
"Iliuard to If umaiu) and Drmeatlr Anl--
jiiala." "aUivlronmenUI hazard"'and
(Thyalcft| pr Chemical Hazard."
] recait
Monary ataternenu are r«4Mlr«d Indi-
cating l|te particular hazard, the
route(a) of exposure and the precau-
tlona to be taken to avoid accident.
Injury or damage. The'precautionary
paragraph ahall be Immediately pre-
ceded by ||ie appropriate hazard algnal
word.
(U) The following table deplete typi-
cal precautionary atatemenla. Theue
alatemenla must be modified or ex-
panded, to aeflect apep|(|o |ia«ard4.
Uikml. Cu Mil M to •».«. on >Mnr«
ao«i*M <* he. MitoU Mill
aW.»« l
kto>«4 |
o» nut (H h •«...
HwuU M »M»M«4 (Ap-
4 Ml3? to ffii U* "If * Wh°,re » "'•,ta' Precautionary alatemenU aro
r l •t«llng the nature pf t
»
doineatlc an) hazard. M^ t >e appropriate
-------
1142.10
(vll) A true statement UMd In *uch a
way a* to give a faUe or mlihtadlng Im-
pression to the purcha**r;
label dUctalmer* wh|ch negat*
or detract from labalhuj *tatemenU re-
quired under the Act and tlteae regula-
tions;
Nantt. brand, or trademark (1)
'fhe name, brand, or trademark under
which the pesticide product U *old
•hall appear on the Iront pane) of the
label.
' (Ik H» name, brand, or trademark
may appear on the label which:
(I) I* falae or mUleadlng. or
(II) lla* not been approved by the
Administrator through registration or
tupplemenlal registration a* an addi-
tional name pursuant to \161 «(bHf >.
(c) Hame and eddre** of producer.
registrant, or per*on for wttom pro-
duced. An unqualified name and ad-
dress given on l|i« label *hall be con-
sidered a* the name and address of the
producer. If the registrant'* name ap-
pear* on Ihe label and the registrant U
not the producer, or II the name ol the
person lor whom the pesticide wa*
produced appear* on l|ie label, It mu*l
be qualified by appropriate wording
•ucli M "Packed for ' t »." "Platflbttt-
ed by » * »." or "Sold by * * f" to *|tow
that the nan** I* not lh*t «f W»« Pf°-
ducer.
Mt( tMlphf pr w«aiHf» ft/ eoa-
feitU. <|| The net weight or mea*ur»
of coi»lenl (hall be e«olu*|ye of wrap-
per* or other material* end, *nal| be
the average content unlem
elated a* a minimum quantity.
()) |f the pesticide I* a liquid. M><
net content alatement ahafl be lfl
term* of liquid measure at M* V ounce*" father
t|kan "i4 ounce*."
(Ik la addition t« the required Widl* '
•pectfted. nei content fnay be ex-
pressed In metr|e unite.
(g) Variation above minimum con-
tent or around an average U permU*)-
Me only to the extent that It tepre
aent* deviation unavoidable In good
manufacturing practice. Variation
below a atated minimum U not permit-
ted.. I'1 no ca*e ihall the average con-
tent of the package* hi a shipment fall
below the stated average content.
(e) product wisirailoN niimtxr.
The registration number assigned |o
the pe*tlc|de product at the lime of
registration ahall appear on the label.
preceded by the phrase "Ki'A Ilegl*
[ration No.." or the phrase "WA Ref,
Ho." The regUtratlon number thai! M
aet In type of a sko and atyle similar |e
other print on that part ol the label
on which It appear* and thai! run V*1'
allul to It. The registration number
and the required Identifying phrase
•hall not appear In *uch a manner as
|o suggest or Imply recommendation
or endorsement of the product by M>?
Agency.
(0 producing ««iabJ|*Jlir|crifl r«0U-
fruilon number. The producing B*taU-
lluhment registration number preced-
ed, by the phrase "W*, Gat-". «l Vkf
APPENDIX IV-1
(continued)
llnal establishment »t which the prod-
uct waa produced may apt>«ar In any
auitabl* location on the |*b«l or Imme
dlale container- |t inuat appear on the
wrapper °* outside conUlner of the
package If Ihe K|'A eslsldlshmcnt reg-
Luallon nuuiber PU tl*e |uii|icdla|e
container cannot be clearly lead
through »«c» wrapper or
•(. Tl»« U»el of each pe«tlcld« product
mu*t bear • *l»U««»«»t whl^ll contain*
the name ami percentage by weight of
f«cl) actlva Ingredient, the tola) per-
MDlag* by welg|4 «' »» M»f»t Ingredl-
tnU; and II t»« p»*tlctdp cuntaln* ar
icidc In any (orm, a *tatuiHent of (tie
percentage* of total a*ck»ie m»kca It hnpfactloable to
Pl»c« (he Ingredient (latement on the
front panel of the |i>b«l. pennMon
m»y be «ran(ed tor the Uigrtdlcni
M»Uinent to appear eLe^hof e.
(Ilk Hie te«t of the Ingredient «(a(e-
nunt mutt run parallel wl|h other
lent on the pane) on which It appear*.
»ltd iiuut be clearly dUttnguU>h»Ue
lf«m and mu*t not be placed l»> the
My ul other tc»(.
0) Hornet (o It vied in fi^reifleiU
. The name uaed (or cacti In-
«hal| be «,a , ».cc«plcd
, U Iherc U oi,e, lo|
P)iei||M (tame. TJ'«
conunon name, may be u*>d alone only
If It U well known. If no common name
ia* been e*tabll*hed, the chemical
name a|one *!>at| bo used. |n no ca*e
Will the u*e of a trademark or proprl-
ftary name he permitted unless such
name |)M been accepted a* a common
name by the AdmlnUtr«tor |i|tdcr the
authority of Uectlon aa.
• (4) SttUn\enlt a/ per«loglca|
hazard Including hazard to children.
environmental hazard. U"J (ihysicul of
two iinimur
-------
s 1*9.10
cacy. and safety o| (ho formulated
end use product, may not consider any
data as supporting tha application.
except the following data:
(I) The data the applicant ha* sub
milted to EPA under paragraph (b) pf
this •ecllon;
(2) Other data pertain!"* fo the
•afety o( the product'* active Ingredi-
ents, rather than to tha aafety °( MlP
end-u&a product; and
(3) Existing tolerances, food additive
regulation*, exemptions, and other
clearance* Issued under the federal
Food, Drug, and Cosmetic Act. ,
(o) it the applicant know* that any
Item of data he submitted under thl*
aecllon WM generated by (or at the ex-
ponae of) another person who original-
ly aubmltled the data \o KPA (or m
predecessor, USOA) on or alter Janu-
ary }. 1»'|0, to support an application
for registration, experimental use
penult, of amendment adding a new
use to an existing registration, or (or
reregUtratlon (unless the applicant
and the original data submitter |>*vo
reached written agreement on the
amount and the frm* ol payment of
any compensation, that may be pay-
able under PIFUA section
XcMIXDMII) with regard to approval
of the Application), the applicant shall
•ubmlt to EPA a atatement that he
has furnished to each inch Identified
original data submitter*
(DA notification of the applicant'*
Intent to apply for registration. Includ.-
Ing the proposed product name;
Cl) An offer to pay the person com-
penaatlon. with regard to the approval
of the application, to the extent re-
quired by FIFIU section* ^cM|MU)
.and3(cK»KD); r
(3) An Identification of the |tem(*)
of data to which the offer applies;
(t) An offer to commence negotia-
tion* to ascertain the amount and
term* of compensation to be paid; and
(6) The applicant'* name, address.
and telephone number.
(f) If the applicant'* product con-
tains any active Ingredient other than
those that are present aolely because
of the Incorporation Into the product.
di|r|ng formulation, pf one of more
other registered pesticide product*
purchased from another producer,
then the applicant «|ial| also comply
l f nvli«nm«n|
with 1 183 »-6 a* to *uc|i active Ingredi-
ent. and the application shall contain,
tin acknowledgment that (or purpose*
of flpflA section 3|-
pently the following:
(I) The name, brand, or trademark
under which the product I* sold a* pre-
scribed, In paragraph (b) pf this *ec-
tlon;
(II) The name and addrea* of the
producer, registrant, or person (or
Whom produced as prescribed. |i| para-
graph
(vlll) The direction* for use a* Pre-
scribed III paragraph (I) pf Hit*.
(Ix) The use c|uAiil(lcutlun(s) a* pre-
scribed |n paragraph 0) Pf this ieclloii.1
(1) fromj't«nc* and tcuibtHty. (I) Al|
word*, qtaleinenla, graphic lepresenta-
tlon*. design* pr other lolormatlon re-
quired on the labeling by the Act or
the regulation* |n thl* part nuul be
clearly legible to a peruon w)th normal
vision, and mM«l be placed with such
corup|c|jou*nes4 (a* compared with
Otiier words, «tatemei)|». deslgiu. or
graphic matUr on the labeling) and
expressed ||< such torni* a* to reader It
likely to be read and undeistood. by
the ordinary Individual under custom-
ary condition* of puiclnao a»(| u*e.
(II) All reoulfed label text nuut^ {
(A) DC set ||) • point or larger type;
(Q) APPt*r on a cluaf coolrasllng
Background; aiwl
(C) Not be obscured or crowded-
fo be \uce secure-
ly altached. to the ImmedUle contain-
er o( the pesticide product. For pur-
poses of thla Section. anv| the |nU-
brand .ig provision* of Ilia Act. "se-
curely attached" shall mean that a
label can reasonably be expected to
remain affixed during |l|tt foreseeable
conditions and period ol use. If the Im-
mediate container |s enclosed within a,
wrapper or ouUlde conUlner through
which the label cannot be clearly read,
(he |abe| must sluu be tecurely at-
tached to such oiiUMo wrapper or con-
tainer; If It In a part o( (he package M
customarily dlslrlbulcd or sold-
(II) TP?»* con an4 other bulk con-
fainef4-(A) Tr»nii>or(uttoii. While a,
pesticide product M (it transit, the ap-
proprlate provision* of iff CKH Pajt*
(70-180, concerning the transportation
Of hazardous material*, and specifical-
ly t|io«e provision* concerning the la-
beling, ptaiklng and placarding o( ,K>Z
ardoua inaterlals and the yen|r.le» c»f-
rylng them, define (he boalc Federal
requirements. In addition, when any
registered peptlclde product U traivs-
porled. In a fank car, funk truck or
other mobile or portable bulk contain-
er, a copy of the accepted label mual
be attached to t|te shipping paper*.
and left with tilt) consignee at the time
pf delivery.
A false or misleading statement
Concerning the effectiveness of the
product a* a pesticide or device;
(III) A fal*e or misleading statement
about the value of the product for
purposes other than aa a pesticide or
device;
(lv> A false or misleading comparison.
with Other pesticides or devices;
(V) Any statement directly or Indi-
rectly Implying that the pvsllclde or
device la recommended or endorsed by
any agency of the Federal Oovtin-
(Vl) The name of a pesticide which
contains two or moro principal active
Ingredient* II the name *uggesU one
or more but not all such principal
active Ingredient* eye|t though the
(tames of the other Ingredients are
«|aU4 elsewhere In the labeling;
-------
APPENDIX IV-2
LABELING REQUIREMENTS OF THE FIFRA, AS AMENDED (REFER TO THE SAMPLE LABELS FOLLOWING)
ITEM
1
2
3
4
5
6B
7
7A
7B
LABEL ELEMENT
Product name
Company name
and address
Net contents
EPA Est. No.
EPA Reg. No.
Ingredients
statement
Pounds/gallon
statement
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
APPLICABILITY
OF REQUIREMENT
All products
All products
All products
All products
All products
All products
Liquid products
where dosage
given as Ibs.
ai/unit area
All products
All products
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
None
None
None
None
Front panel
Front panel
Front panel
Front panel
Front panel
PREFERRED
Center front
panel
Bottom front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel,
immediately
before or
following
Reg. No.
Immediately
following
product name
Directly below
the main
ingredients
statement
Above signal
word
Immediately
below child
hazard
warning
COMMENTS
If registrant is not the producer, must
be qualified by "Packed for . . .,"
"Distributed by. . .," etc.
May be in metric units in addition to
U.S. units
Must be in similar type size and run
parallel to other type.
May appear on t
the label.
Text must run parallel with other text
on the panel .
All front panel precautionary statements
must be grouped
blocked .
Note type size requirements.
Note type size requirements.
-------
APPENDIX IV-2 (continued)
ITEM
1C
ID
IE
8
8A
8B
LABEL ELEMENT
Skull & cross-
bones and word
POISON (in red)
Statement of
pract ical
treatment
Referral
statement
Side/back panel
precautionary
statements
Hazards to
humans and
domestic
animals
Environmental
hazards
APPLICABILITY
OF REQUIREMENT
All products
which are Cat-
egory I based
on oral, der-
mal, or inhala-
tion toxicity
All products
in Categories
I, II, and III
All products
where pre-
cautionary
labeling
appears on
other than
front panel.
All products
All products
in Categories
I, II, and III
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
Category I:
Front panel
unless refer-
ral statement
is used.
Others :
Grouped with
side panel
precautionary
statements.
Front panel
None
None
None
PREFERRED
Both in close
proximity to
signal word
Front panel
for all.
Top or side
of back panel
preceding
directions
for use
Same as above
Same as above
COMMENTS
Must be grouped under the headings in
8A, 8B, and 8C; preferably blocked.
Must be. preceded by appropriate signal
word.
Environmental hazards include bee
caution where applicable.
-------
APPENDIX IV-2 (continued)
ITEM
8C
9A
9C
10A
IOC
10D
U.S.
LABEL ELEMENT
Physical or
chemical
hazards
Restricted
block
Misuse
statement
Re-entry
statement
Storage and
disposal block
Directions
for use
APPLICABILITY
OF REQUIREMENT
All pressurized
products, others
with flash
points under
150°F
All restricted
products
All products
All
cholinesterase
inhibitors
All products
All products
PLACEMENT ON LABEL
REQUIRED
None •
Top center
of front
panel
Immediately
following
statement of
classifica-
tion or
ahead of
directions
for use
In the
directions
for use
In the
directions
for use
None
PREFERRED
Same as above
Preferably
blocked
Immediately
after misuse
statement
Immediately
before
specific
directions
for use or
at the end of
directions
for use
None
COMMENTS
Includes a statement of the terms of
restriction. The words "RESTRICTED USE
PESTICIDE" must be same type size as
signal word.
Must be set apart and clearly distin-
guishable from from other directions
for use.
May be in metric as well as U.S. units
-------
Appendix IV-3
PHYSICAL-CHEMICAL HAZARDS
Criteria
I. Pressurized Containers
A. Flashpoint at or below
20°F; or if there is a
flashback at any valve
opening.
B. Flashpoint above 20°F
and not over 80°F; or
if the flame extension
is more than 18 inches
long at a distance of
6 inches from the
valve opening.
C. ALL OTHER PRESSURIZED
CONTAINERS
II. Non-Pressurized Containers
A. Flashpoint at or below
20°F.
B. Flashpoint above 20°F
and over 80°F.
C. Flashpoint over 80°F
and not over 150°F.
D. Flashpoint above
150°F.
Required Label Statement
Extremely flammable.
Contents under pressure.
Keep away from fire, sparks,
and heated surfaces. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat, sparks, and flame. Do
not puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces.
Flammable. Keep away from
heat and open flame.
Do not use or store near
heat and open flame.
None required.
-------
Appendix IV-5
STORAGE AND DISPOSAL INSTRUCTIONS FOR PESTICIDES
All products are required to bear specific label instructions
about storage and disposal. Storage and disposal instructions
must be grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL. Products
intended solely for domestic use need not include the heading
"STORAGE AND DISPOSAL." The STORAGE AND DISPOSAL heading
must appear in the minimum type size listed below:
Size of label
front panel in
Required type size
for the heading
STORAGE AND DISPOSAL
square inches (all capitals)
10 and under 6 point
Above 10 to 15 8 point
Above 15 to 30 10 point
Over 30 12 point
Storage and disposal instructions must be set apart and
clearly distinguishable from other directions for use.
Blocking storage and disposal statements with a solid line is
suggested as a means of increasing their prominence.
A. Storage Instructions;
All product labels are required to have appropriate storage
instructions. Specific storage instructions are not prescribed
Each registrant must develop his own storage instructions,
considering, when applicable, the following factors:
1. Conditions of storage that might alter the composition or
usefulness of the pesticide. Examples could be temperature
extremes, excessive moisture or humidity, heat, sunlight,
friction, or contaminating substances or media.
2. Physical requirements of storage which might adversely
affect the container of the product and its ability to
continue to function properly. Requirements might include
positioning of the container in storage, storage or damage
due to stacking, penetration of moisture, and ability to
withstand shock or friction.
3. Specifications for handling the pesticide container,
including movement of container within the storage area,
proper opening and closing 'procedures (particularly for
opened containers), and measures to minimize exposure
while opening or closing container.
-------
Appendix IV-5
(continued)
4. Instructions on what to do if the container is damaged in
any way, or if the pesticide is leaking or has been
spilled, and precautions to minimize exposure if damage occurs.
5. General precautions concerning locked storage, storage in
original container only, and separation of pesticides
during storage to prevent cross-contamination of other
pesticides, fertilizer, food, and feed.
6. General storage instructions for household products should
emphasize storage in original container and placement in
locked storage areas.
B. Pesticide Disposal Instructions;
The label of all products, except those intended solely for
domestic use, must bear explicit instructions about pesticide
disposal. The statements listed below contain the exact wording
that must appear on the label of these products:
1. The labels of all products, except domestic use, must
contain the statement, "Do not contaminate water, food,
or feed by storage or disposal."
2. Except those products intended solely for domestic use,
the labels of all products that contain active ingredients
appearing on the "Acutely Hazardous" Commercial Pesticide
Products List (RCRA "E" List) at the end of this appendix
or are assigned to Toxicity Category I on the basis of
oral or dermal toxicity, skin or eye irritation potential,
or Toxicity Category I or II on the basis of acute inhala-
tion toxicity must bear the following pesticide disposal
statement:
"Pesticide wastes are acutely hazardous. Improper dis-
posal of excess pesticide, spray mixture, or rinsate is
a violation of Federal Law. If these wastes cannot be
disposed of by use according to label instructions,
contact your State Pesticide or Environmental Control
Agency, or the Hazardous Waste representative at the
nearest EPA Regional Office for guidance."
The labels of all products, except those intended for
domestic use, containing active or inert ingredients
that appear on the "Toxic" Commercial Pesticide Products
List (RCRA "F" List) at the end of this appendix or
presently meet any of the criteria in Subpart C, 40 CFR
261 for a hazardous waste must bear the following pesticide
disposal statement:
-------
Appendix IV-5
(continued)
"Pesticide wastes are toxic. Improper disposal of excess
pesticide, spray mixture, or rinsate is a violation of
Federal Law. If these wastes cannot be disposed of by
use according to label instructions, contact your State
Pesticide or Environmental Control Agency, or the Hazardous
Waste representative at the nearest EPA Regional Office
for guidance."
Labels for all other products, except those intended for
domestic use, must bear the following pesticide disposal
statement:
"Wastes resulting from the use of this product may be
disposed of on site or at an approved waste disposal
facility."
3. Products intended for domestic use only must bear the
following disposal statement: "Securely wrap original
container in several layers of newspaper and discard in
trash."
C. Container Disposal Instructions
The label of each product must bear container disposal
instructions appropriate to the type of container.
1. All products intended for domestic use must bear one
of the following container disposal statements:
Container Type
Statement
Non-aerosol products
(bottles, cans, jars)
Non-aerosol products
(bags)
Aerosol products
Do not reuse container (bottle, can, jar).
Rinse thoroughly before discarding in trash.
Do not reuse bag. Discard bag in trash.
Replace cap and discard containers in
trash. Do not incinerate or puncture.
2. The labels for all other products must bear container disposal
instructions, based on container type, listed below:
Container Type
Statement
Metal
containers
(non-aerosol)
Plastic containers
Glass containers
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or by
other procedures approved by state and local
authorities.
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or
incineration, or, if allowed by state and
local authorities, by burning. If burned,
stay out of smoke.
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved state and local procedures.
-------
Container Type
Appendix IV-5
(continued)
Statement
Fiber drums
with liners
Paper and
plastic bags
Compressed gas
cylinders
Completely empty liner by shaking and
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
reused^, dispose of in the same manner.
Completely empty bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning. If burned, stay
out of smoke.
Return empty cylinder for reuse (or
similar wording).
iManufacturer may replace this phrase with one indicating
and how fiber drum may be reused.
2. The labels for all other products must bear container
disposal instructions, based on container type, listed
on the first page of this Appendix.
whether
-------
Appendix IV-5
(continued)
Pesticides that are hazardous wastes under 40 CFR 261.33(e) and (f)
when discarded.
"Acutely Hazardous" Commercial Pesticides (RCRA "E" List)
Active Ingredients, (no inerts);
Acrolein
Aldicarb
Aldrin
Allyl alcohol
Aluminum phosphide
4-Aminopyridine
Arsenic acid
Arsenic pentoxide
Arsenic trioxide
Calcium cyanide
Carbon disulfide
p-Chloroaniline
Cyanides (soluble cyanide salts, not specified elsewere)
Cyanogen chloride
2-Cyclohexyl-4,6-dinitrophenol
Dieldrin
0,0-Diethyl S-[2-ethylthio)ethyl] phosphorodithioate
(disulfoton, Di-Syston)
0,0-Diethyl 0-pyrazinyl phosphorothioate (Zinophos)
Dimethoate
0,0-Dimethyl 0-p-nitrophenyl phosphorothioate (methyl parathion)
4,6-Dinitro-o-cresol and salts
4 ,6-Dinitro-o-cyclohexylphenol
2,4 Dinitrophenol
Dinoseb
Endosulfan
Endothall
Endrin
Famphur
Fluoroacetamide
Heptachlor
Hexanethyl tetraphosphate
Hydrocyanic acid
Hydrogen cyanide
Methomy1
alpha-Naphthylthiourea (ANTU)
Nicotine and salts
Octamethylpyrophosphoramide (OMPA, schradan)
Parathion
-------
Appendix IV-5
(cont inued)
"Acutely Hazardous" Commercial Pesticides (RCRA "E" List)
Active Ingredients continued:
Phenylmercuric acetate (PMA)
Phorate
Potassium cyanide
Propargyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacetate
Strychnine and salts
0,0,0,0-Tetraethyl dithiopyrophosphate (sulfotepp)
Tetraethyl pyrophosphate
Thallium sulfate
Thiofanox
Toxaphene
Warfarin
Zinc phosphide
There are currently no inert ingredients for commercial pesticides
on the "Acutely Hazardous" List (RCRA "E" List).
-------
Appendix IV-5
(continued)
"Toxic" Commercial Pesticide Products (RCRA "F" List)
Active Ingredients:
Acetone
Acrylonitrile
Amitrole
Benzene
Bis( 2-ethylhexyDpthalate
Cacodylic acid
Carbon tetrachloride
Chloral (hydrate)
Chlordane (technical)
Chlorobenzene
4-Chloro-m-cresol
Chloroform
o-Chlorophenol
4-Chloro-o-toluidine hydrochloride
Creosote
Cresylic acid
Cyclohexane
Decachlorooctahydro-1,3 ,4-metheno-2H-cyclobuta [c,d] -pentalen-2-one
(kepone, chlordecone)
1,2-Dibromo-3-chloropropane (DBCP)
Dibutyl phthalate
S-3 ,3-( Dichloroallyl diisopropylthiocarbamate (diallate, Avadex)
o-Dichlorobenzene
p-Dichlorobenzene
Dichlorodifluoromethane (Freon 12®)
3 , 5-Dichloro-N-( 1, l-dimethyl-2-propynyl) benzamide (pronamide ,Kerb )
Dichloro diphenyl dichloroethane (ODD)
Dichloro diphenyl trichloroethane (DDT)
Dichlorethyl ether
2,4-Dichlorophenoxyacetic, esters and salts (2,4-D)
1,2-Dichloropropane
1,3-Dichloropropane (Telone)
Dimethyl phthalate
Ethyl acetate
Ethyl 4,4'-dichlorobenzilate (chlorobenzilate)
Ethylene dibromide (EDB)
Ethylene dichloride
Ethylene oxide
Formaldehyde
Furfural
Hexachlorobenzene
Hexachlorocyclopentadiene
Hexachloroethane
Hydrofluoric acid
-------
Appendix IV-5
(continued)
"Toxic" Commercial Pesticide Products (RCRA "F" Listj^
Active Ingredients:
Isobutyl alcohol
Lead acetate
Lindane
Maleic hydrazide
Mercury
Methyl alcohol
Methyl bromide
Methyl chloride
2,2'-Methylenebis (3,4,6-trichlorophenol) (hexachlorophene)
Methylene chloride
Methyl ethyl ketone
4-Methyl-2-pentanone (methyl isobutyl ketone)
Naphthalene
Nitrobenzene
p-Nitrophenol
Pentachloroethane
Pentachloronitrobenzene (PCNB)
Pentaclorophenol
Phenol
Phosphorodithioic acid, 0,0-diethyl, methyl ester
Propylene dichloride
Pyridine
Resorcinol
Safrole
Selenium disulfide
Silvex
1,2,4,5-Tetrachloroben zene
1,1,2,2-Tetrachloroethane
Tetrachloroethylene
2,3,4,6-Tetrachlorophenol
Thiram
Toluene
1,1,1-Trichloroethane
Trichloroethylene
Trichloromonofluoromethane (Freon 11®)
2,4,5-Tri chlorophenol
2,4,6-Trichlorophenol
2,4,5-Trichlorophenoxyacetic acid (2,4,5-T)
Xylene
-------
Appendix IV-5
(continued)
"Toxic" Commercial Pesticide Products (RCRA "F" List)
Inert Ingredients:
Acetone
Acetonitrile
Acetophenone
Acrylic acid
Aniline
Benzene
Chlorobenzene
Chloroform
Cyclohexane
Cyclohexanone
Dichlorodifluoromethane ( Freon 12®)
Diethyl phthalate
Dimethylaniine
Dimethyl phthalate
1,4-Dioxane
Ethylene oxide
Formaldehyde
Formic acid
Isobutyl alcohol
Meleic anhydride
Methyl alcohol (methanol)
Methyl ethyl ketone
Methyl methacrylate
Naphthalene
Saccharin and salts
Thiourea
Toluene
1,1,1-Trichloroethane
1,1,2-Trichloroethane
Trichlorofluoromethane (Freon 11®)
Vinyl chloride
Xylene
------- |