TOXICOLOGICAL PROFILE FOR
TRIETHYLENE GLYCOL DINITRATE
Criteria and Standards Division
Office of Drinking Water
U.S. Environmental Protection Agency
Washington, DC 20460
August 1989
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August 1989
TOXICOLOGICAL PROFILE
FOR
TRIETHYLENE GLYCOL DINITRATE
Criteria and Standards Division
Office of Drinking Water
U.S. Environmental Protection Agency
Washington, DC 20460
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TRIETHYLENE GLYCOL DINITRATE
A. GENERAL
1. CAS Number: 111-22-8
2. RTECS Number: YE5500000
3. General Name/Svnonvms: Ethanol, 2,21-[l,2-ethanediylbis(oxy)]bis-,
dinitrate
TEGDN
4. Molecular Formula: CeH12N208
5. Molecular Weight; 240
6. Structure;
N-0-CHZ CHj-O-CHg CH2-O-CH2 CM2-O-N
o' \
B. PHYSICAL AND CHEMICAL PROPERTIES
1. State: No information was found.
2. Vaoor Pressure: No information was found.
3. Melting Point: No information was found.
4. Boiling Point; No information was found.
5. Specific Gravity: No information was found.
6. Solubility; No information was found.
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7. Log Kow: No information was found.
8. UV Absorption: No information was found.
C. PHYSICAL/CHEMICAL EQUILIBRIUM FACTORS
1. Bioconcentration Factors (BCR: No information was found.
2. Kwa: No information was found.
3. !<«: No information was found.
D. ENVIRONMENTAL FATE
1. Photolysis: No information was found.
2. Leaching: No information was found.
3. Route of Water Contamination: No information was found.
4. Hvdrolvsis: No information was found.
5. Plant Uptake: No information was found.
6. Microbial Degradation: No information was found.
7. Persistence in Soil/Water: No information was found.
8. Byproducts: No information was found.
9. Vaporization; No information was found.
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E. ACUTE TOXICITY IN MAMMALS
Animal/strain/sex
Route
LD50 (mg/kg)
Reference
Mice/NMTRI/M
Rat/Sprague-
Dawley/M
Rat/Sprague-
Dawley/M
Rat/Sprague-
Dawley/M
Guinea pig/Hartley/M
Intra- 945 (792-1,126)' Andersen and Mehl
peritoneal (1973)
Oral 1,000 (733-1,365) Andersen and Mehl
(1973)
Intra- 796 (785-807) Andersen and Mehl
peritoneal (1973)
Sub- 2,520 (1,720-3,660) Andersen and Mehl
cutaneous (1973)
Intra- 700 (586-835) Andersen and Mehl
peritoneal (1973)
'95% confidence limits.
Andersen and Mehl (1973) observed only 30 to 40% methemoglobinemia in groups
of four Sprague-Dawley rats given a single subcutaneous injection of 3120
mg/kg TEGDN. Rats given lethal doses of TEGDN exhibited ataxia, lethargy, and
violent tremors, and they were hyperreactive to auditory and tactile stimuli.
In another experiment, groups of three to six Sprague-Dawley rats (sex not
specified) were given a single intraperitoneal injection of 796 mg/kg TEGDN;
survivors were sacrificed at 24, 48, 72, 96, and 168 hours; and plasma enzyme
activities were measured. TEGDN caused large, long-lasting increases in all
plasma enzyme activities (alkaline phosphatase, asparate aminotransferase,
creatine kinase, and lactic dehydrogenase). The severe tremors observed in
rats together with the increases in plasma enzyme activities suggest a
neurological toxicity for this dinitrate (Andersen and Mehl, 1973).
Daily dermal applications of 21 mmole/kg (approximately 5 g/kg) caused the
death of 9 of 11 male New Zealand white rabbits treated for 3 weeks; the mean
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time to death was 17 days. Rabbits lost 20% of their initial body weight and
appeared strikingly emaciated (Andersen and Mehl, 1973).
F. SKIN AND EYE IRRITATION AND SENSITIZATION IN MAMMALS
No information was found.
G. SUBCHRONIC TOXICITY IN MAMMALS
Groups of five male Hartley guinea pigs were given intraperitoneal
injections of 0, 100, 200, or 400 mg/kg TEGDN daily for 15 days. Dose-related
decreases in both body weight gain and food consumption were observed during
the 15-day treatment period. No other parameters or results were reported
(Andersen and Mehl, 1973).
H. REPRODUCTIVE EFFECTS AND TERATOGENICITY IN MAMMALS
No information was found.
I. MUTAGENICITY/GENOTOXICITY
No information was found.
J. CHRONIC/CARCINOGENICITY STUDIES IN MAMMALS
No information was found.
K. PHARMACOKINETICS IN MAMMALS
No information was found.
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L. HUMAN HEALTH EFFECTS
No information was found.
M. EXISTING STANDARDS/CRITERIA
No information was found.
N. REFERENCES
Andersen ME, Mehl R6. 1973. A comparison of the toxicology of triethylene
glycol dinitrate and propylene glycol dinitrate. Am. Ind. Hyg. Assoc. J.
34:526-532.
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