TOXICOLOGICAL PROFILE FOR
TRIFLUOROCHLOROMETHANE
Criteria and Standards Division
Office of Drinking Water
U.S. Environmental Protection Agency
Washington, DC 20460
June, 1989
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TOXICOLOGICAL PROFILE
FOR
TRIFLUOROCHLOROMETHANE
June 1989
Criteria and Standards Division
Office of Drinking Water
U.S. Environmental Protection Agency
Washington, DC 20460
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TRIFLUOROCHLOROMETHANE
A. GENERAL
1. CAS Number; 75-72-9
2. RTECS Number: PA6410000
3. General Name/Svnonvms: Chlorotrifluoromethane
F1uorocarbon-13
Freon-13
Monochlorotri f1uoromethane
4. Molecular Formula; CCLF3
5. Molecular Weight; 104.47
6. Structure; p
I
F — C — Cl
I
F
B. PHYSICAL AND CHEMICAL PROPERTIES
1. State; Gas (colorless with an ethereal odor) Sax and Lewis (1987)
2. Vapor Pressure; No information was found.
3. Melting Point; -181°C Sax and Lewis (1987)
4. Boiling Point; -81.4°C Sax and Lewis (1987)
5. Specific Gravity; 1.298 at -30°C Weast (1988)
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6. Solubility; 0.009 g/100 g water at 25°C and 1 atm Weast (1988)
7. Log Kow: No information was found.
8. UV Absorption: No informal ton was found.
C. PHYSICAL/CHEMICAL EQUILIBRIUM FACTORS
1. Bioconcentration Factors (BCR; No information was found.
2. Kwa: No information was found.
3. !<„: No information was found.
D. ENVIRONMENTAL FATE
1. Photolysis: Chou et al. (1978) reported that direct photolysis
accounts for less than 10% of the removal of Freon-13 from the
atmosphere. The remainder (>90%) is most likely removed from the
atmosphere via reaction with 0(1D). The compound appears to persist in
the air for an extensive period, with reported atmospheric residence
times of 180 to 450 years. Long-term atmospheric persistence of
Freon-13 is believed to be related to the compound's low photo
absorption cross-sections (mean value, 0.36 x 10"20 cm2 at 296 K).
2. Leaching: No information was found.
3. Route of Water Contamination: No information was found.
4. Hydrolysis; No information was found.
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5. Plant Uptake: No information was found.
6. Microbial Degradation; No information was found.
7. Persistence in Soil/Water: No information was found.
8. Byproducts: No information was found.
9. Vaporization: No information was found.
E. ACUTE TOXICITY IN MAMMALS
No information was found.
F.. SKIN AND EYE IRRITATION AND SENSITIZATION IN MAMMALS
No information was found.
G. SUBCHRONIC TOXICITY IN MAMMALS
No information was found.
H. REPRODUCTIVE EFFECTS AND TERATOGENICITY IN MAMMALS
No information was found.
I. MUTAGENICITY/GENOTOXICITY
Data are presented in tabular form on page 4.
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1. NUTAGENICITV/GENOTOX1CITY
Test
Strain
Activation
Oose/concentrat i on
Toxic effects
Reference
DNA synthesis
Escherichia
coli
None
34 mL/nin
gas flow rate
for 5 minutes
Significant decrease
in survival rate
occurred. A significant
increase in the rate of DNA
synthesis was noted,
with a 789.6X increase
in 3H-thymidine incor-
poration.
Oujesky and
Job (1977)
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J. CHRONIC/CARCINOGENICITY STUDIES IN MAMMALS
No information was found.
K. PHARMACOKINETICS IN MAMMALS
No information was found.
L. HUMAN HEALTH EFFECTS
No information was found.
M. EXISTING STANDARDS/CRITERIA
No information was found.
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N. REFERENCES
Chou CC, Milstein RJ, Smith WS, Ruiz HV, Molina MJ, Rowland FS. 1978.
Stratospheric photodissection of several saturated perhalo chlorofluorocarbon
compounds in current technological use (fluorocarbons-13, -113, -114, and
-115). J. Phys. Chem. 82: 1-7.
Oujesky H, Job L. 1977. Effects of five gaseous atmospheres on the survival
rate and DMA synthesis in Escherichia coli. Dev. Ind. Microbiol. 18: 451-
456.
Sax N, Lewis RJ. 1987. Hawley's Condensed Chemical Dictionary, llth ed.
Van Nostrand Reinhold Company. New York, NY.
Weast RC. 1988. CRC Handbook of Chemistry and Physics. 69th ed. CRC Press,
Inc., Boca Raton, FL.
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