TOXICOLOGICAL PROFILE FOR
TRIFLUOROCHLOROMETHANE
Criteria and Standards Division
Office of Drinking Water
U.S. Environmental Protection Agency
Washington, DC  20460
June, 1989

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       TOXICOLOGICAL PROFILE

                FOR

       TRIFLUOROCHLOROMETHANE
             June 1989
   Criteria  and  Standards  Division
      Office of Drinking Water
U.S. Environmental Protection Agency
       Washington,  DC   20460

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                            TRIFLUOROCHLOROMETHANE



A.  GENERAL


    1.  CAS Number;   75-72-9


    2.  RTECS  Number:   PA6410000
    3.   General  Name/Svnonvms:   Chlorotrifluoromethane
                                F1uorocarbon-13
                                Freon-13
                                Monochlorotri f1uoromethane
    4.  Molecular Formula;   CCLF3



    5.  Molecular Weight;   104.47


    6.  Structure;      p

                        I
                   F — C — Cl

                        I
                        F

 B.  PHYSICAL AND  CHEMICAL PROPERTIES


    1.  State;   Gas (colorless with an ethereal  odor)   Sax and Lewis (1987)


    2.  Vapor Pressure;  No information was found.


    3.  Melting Point;  -181°C                          Sax and Lewis (1987)



    4.  Boiling Point;  -81.4°C                         Sax and Lewis (1987)



    5.  Specific Gravity;   1.298 at -30°C               Weast (1988)
                                      -1-

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    6.  Solubility;  0.009 g/100 g water at 25°C and 1 atm    Weast (1988)

    7.  Log Kow:   No information was found.

    8.  UV Absorption:  No informal ton was found.


C.  PHYSICAL/CHEMICAL  EQUILIBRIUM  FACTORS

    1.  Bioconcentration Factors (BCR;  No information was  found.

    2.  Kwa:   No information  was found.

    3.  !<„:   No  information  was found.


D.  ENVIRONMENTAL  FATE

    1.  Photolysis:  Chou et al. (1978)  reported that direct photolysis
       accounts  for less than  10% of the removal  of Freon-13 from  the
       atmosphere.  The remainder (>90%) is  most  likely  removed  from the
       atmosphere via  reaction with 0(1D).   The compound appears to  persist in
       the  air  for an  extensive period, with reported  atmospheric  residence
       times of  180 to 450  years.   Long-term atmospheric persistence of
       Freon-13  is believed to be related to the  compound's low  photo
       absorption cross-sections  (mean  value,  0.36 x  10"20 cm2 at 296 K).

    2.  Leaching:   No  information  was found.

    3.  Route of Water  Contamination:  No information was found.

    4.  Hydrolysis; No information was  found.
                                      -2-

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   5.  Plant Uptake:  No information was found.





   6.  Microbial Degradation;  No information was found.





   7.  Persistence in Soil/Water:  No information was found.





   8.  Byproducts:  No information was found.





   9.  Vaporization:  No information was found.








E.   ACUTE TOXICITY IN MAMMALS





     No information was found.








F..   SKIN AND EYE IRRITATION AND SENSITIZATION IN MAMMALS





     No information was found.








G.   SUBCHRONIC TOXICITY IN MAMMALS





     No information was found.








H.   REPRODUCTIVE EFFECTS AND TERATOGENICITY  IN MAMMALS





     No information was found.








I.   MUTAGENICITY/GENOTOXICITY





     Data are presented in tabular form on page 4.






                                      -3-

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1.  NUTAGENICITV/GENOTOX1CITY
Test
                            Strain
                                                   Activation
                                          Oose/concentrat i on
                                                                                                   Toxic effects
                                                                                                                                   Reference
DNA synthesis
Escherichia
coli
                                                   None
34 mL/nin
gas flow rate
for 5 minutes
Significant decrease
in survival rate
occurred.  A significant
increase in the rate of DNA
synthesis was noted,
with a 789.6X increase
in 3H-thymidine incor-
poration.
Oujesky and
Job (1977)

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J.  CHRONIC/CARCINOGENICITY STUDIES IN MAMMALS





     No information was found.








K.  PHARMACOKINETICS IN MAMMALS





     No information was found.








L.  HUMAN HEALTH EFFECTS





     No information was found.








M.  EXISTING STANDARDS/CRITERIA





     No information was found.
                                      -5-

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N.  REFERENCES

Chou CC, Milstein RJ, Smith WS, Ruiz HV, Molina MJ, Rowland FS.  1978.
Stratospheric photodissection of several saturated perhalo chlorofluorocarbon
compounds in current technological use (fluorocarbons-13, -113, -114, and
-115).  J. Phys. Chem. 82: 1-7.

Oujesky H, Job L.  1977.  Effects of five gaseous atmospheres on the survival
rate and DMA synthesis in Escherichia coli.  Dev. Ind. Microbiol.  18: 451-
456.

Sax N, Lewis RJ.  1987.  Hawley's Condensed Chemical Dictionary,  llth ed.
Van Nostrand Reinhold Company.  New York, NY.

Weast RC.  1988.  CRC Handbook of Chemistry and Physics.  69th ed.  CRC Press,
Inc., Boca Raton, FL.
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