TOXICOLOGICAL PROFILE FOR TRIFLUOROCHLOROMETHANE Criteria and Standards Division Office of Drinking Water U.S. Environmental Protection Agency Washington, DC 20460 June, 1989 ------- TOXICOLOGICAL PROFILE FOR TRIFLUOROCHLOROMETHANE June 1989 Criteria and Standards Division Office of Drinking Water U.S. Environmental Protection Agency Washington, DC 20460 ------- TRIFLUOROCHLOROMETHANE A. GENERAL 1. CAS Number; 75-72-9 2. RTECS Number: PA6410000 3. General Name/Svnonvms: Chlorotrifluoromethane F1uorocarbon-13 Freon-13 Monochlorotri f1uoromethane 4. Molecular Formula; CCLF3 5. Molecular Weight; 104.47 6. Structure; p I F — C — Cl I F B. PHYSICAL AND CHEMICAL PROPERTIES 1. State; Gas (colorless with an ethereal odor) Sax and Lewis (1987) 2. Vapor Pressure; No information was found. 3. Melting Point; -181°C Sax and Lewis (1987) 4. Boiling Point; -81.4°C Sax and Lewis (1987) 5. Specific Gravity; 1.298 at -30°C Weast (1988) -1- ------- 6. Solubility; 0.009 g/100 g water at 25°C and 1 atm Weast (1988) 7. Log Kow: No information was found. 8. UV Absorption: No informal ton was found. C. PHYSICAL/CHEMICAL EQUILIBRIUM FACTORS 1. Bioconcentration Factors (BCR; No information was found. 2. Kwa: No information was found. 3. !<„: No information was found. D. ENVIRONMENTAL FATE 1. Photolysis: Chou et al. (1978) reported that direct photolysis accounts for less than 10% of the removal of Freon-13 from the atmosphere. The remainder (>90%) is most likely removed from the atmosphere via reaction with 0(1D). The compound appears to persist in the air for an extensive period, with reported atmospheric residence times of 180 to 450 years. Long-term atmospheric persistence of Freon-13 is believed to be related to the compound's low photo absorption cross-sections (mean value, 0.36 x 10"20 cm2 at 296 K). 2. Leaching: No information was found. 3. Route of Water Contamination: No information was found. 4. Hydrolysis; No information was found. -2- ------- 5. Plant Uptake: No information was found. 6. Microbial Degradation; No information was found. 7. Persistence in Soil/Water: No information was found. 8. Byproducts: No information was found. 9. Vaporization: No information was found. E. ACUTE TOXICITY IN MAMMALS No information was found. F.. SKIN AND EYE IRRITATION AND SENSITIZATION IN MAMMALS No information was found. G. SUBCHRONIC TOXICITY IN MAMMALS No information was found. H. REPRODUCTIVE EFFECTS AND TERATOGENICITY IN MAMMALS No information was found. I. MUTAGENICITY/GENOTOXICITY Data are presented in tabular form on page 4. -3- ------- 1. NUTAGENICITV/GENOTOX1CITY Test Strain Activation Oose/concentrat i on Toxic effects Reference DNA synthesis Escherichia coli None 34 mL/nin gas flow rate for 5 minutes Significant decrease in survival rate occurred. A significant increase in the rate of DNA synthesis was noted, with a 789.6X increase in 3H-thymidine incor- poration. Oujesky and Job (1977) ------- J. CHRONIC/CARCINOGENICITY STUDIES IN MAMMALS No information was found. K. PHARMACOKINETICS IN MAMMALS No information was found. L. HUMAN HEALTH EFFECTS No information was found. M. EXISTING STANDARDS/CRITERIA No information was found. -5- ------- N. REFERENCES Chou CC, Milstein RJ, Smith WS, Ruiz HV, Molina MJ, Rowland FS. 1978. Stratospheric photodissection of several saturated perhalo chlorofluorocarbon compounds in current technological use (fluorocarbons-13, -113, -114, and -115). J. Phys. Chem. 82: 1-7. Oujesky H, Job L. 1977. Effects of five gaseous atmospheres on the survival rate and DMA synthesis in Escherichia coli. Dev. Ind. Microbiol. 18: 451- 456. Sax N, Lewis RJ. 1987. Hawley's Condensed Chemical Dictionary, llth ed. Van Nostrand Reinhold Company. New York, NY. Weast RC. 1988. CRC Handbook of Chemistry and Physics. 69th ed. CRC Press, Inc., Boca Raton, FL. -6- ------- |