TOXICOLOGICAL PROFILE FOR BENZOTHIAZOLE Criteria and Standards Division Office of Drinking Water U.S. Environmental Protection Agency Washington, DC 20460 June 1989 ------- TOXICOLOGICAL PROFILE FOR BENZOTHIAZOLE June 1989 Criteria and Standards Division Office of Drinking Water U.S. Environmental Protection Agency Washington, DC 20460 ------- BENZOTHIAZOLE A. GENERAL 1. CAS Number: 95-16-9 2. RTECS Number: DL0875000 3. General Name/Svnonvms: Benzosulfanazole l-Thia-3-azaindene 4. Molecular Formula-: C7H5NS 5. Molecular Weight: 135.18 6. Structure: B. PHYSICAL AND CHEMICAL PROPERTIES 1. State: Yellow liquid with unpleasant odor. 2. Vapor Pressure: No information was found. 3. Melting Point: 2.0°C 4. Boilino Point: 227-228°C at 765 mmHg and 131°C at 34 mmHg 5. Specific Gravity; 1.246 6. Solubility: Slightly soluble in water; freely soluble in alchohol and carbon disulfide. Soluble in ether, acetone, and benzene. Sax and Lewis (1987) Weast (1988) Windholz et al. (1983) Sax and Lewis (1987) Windholz (1983); Weast (1988) -1- ------- 7. Log Kn.n.: No information was found. 8. UV Absorption: No information was found. C. PHYSICAL/CHEMICAL EQUILIBRIUM FACTORS 1. Bioconcentration Factors (BCR: No information was found. 2. Kwa: No information was found. 3. !<„: No information was found. D. ENVIRONMENTAL FATE 1. Photolysis: No information was found. 2. Leaching: No information was found. 3. Route of Water Contamination: No information was found. 4. Hydrolysis: No information was found. 5. Plant Uptake: No information was found. 6. Microbial Degradation: No information was found. 7. Persistence in Soil/Water: No information was found. 8. Byproducts: No information was found. 9. Vaporization: No information was found. -2- ------- E. ACUTE TOXICITY IN MAMMALS Animal/strain/sex Route (mg/kg) Effects Reference Rat/F344/M Oral F Oral 493 466 i OJ Antemortem observations included lethargy; ataxia; prostration; lacrimation; squinting; body cool to touch; loose, few, or no stools; crusty eye/muzzle; and yellow/brown stained or damp fur in the peri anal region. Necropsy of animals found dead revealed dark contents of stomach and small intestine; multiple focal, black discolorations of glandular stomachs; diffuse, pale discoloration of livers; diffuse, pale, or red discoloration of lungs; and a distended urinary bladder. Necropsy of terminal sacrifice animals revealed enlarged, dark red spleens; an ovarian cyst; a diaphragmatic hernia; and small testes. Mayhew and Muni (1986) ------- F. SKIN AND EYE IRRITATION AND SENSITIZATION IN MAMMALS No information was found. G. SUBCHRONIC TOXICITY IN MAMMALS No information was found. H. REPRODUCTIVE EFFECTS AND TERATOGENICITY IN MAMMALS No information was found. I. MUTAGENICITY/GENOTOXICITY Data are presented in tabular form on page 5. J., CHRONIC/CARCINOGEN1CITY STUDIES IN MAMMALS No information was found. K. PHARMACOKINETICS IN MAMMALS No information was found. -4- ------- I. MUTAGENICITY/GENOTOXICITY Test Strain Activation Dose/concent ra t i on Toxic effects Reference Ames mutagenicity assay Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1537, TA 1538. S9 1, 0.2, 0.04, 0.008, 0.0016, 0.00032, pL/plate Benzothiazole was not mutagenic with and without metabolic activation. Sano and Korte (1985) I en I ------- L. HUMAN HEALTH EFFECTS No information was found. M. EXISTING STANDARDS/CRITERIA No information was found. -6- ------- N. REFERENCES Mayhew DA, Muni IA. 1986. Dermal, Eye, and Oral Toxicological Evaluations. Phase II. Acute Oral LD50 Determinations of Benzothiazole, Diathiane, and Oxathiane. Fort Detrick, MD: U.S. Army Medical Research and Development Command. Available from DTIC. AD-A172647. Sano S, Korte D. 1985. Mutagenic Potential of Benzothiazole. Fort Detrick, MD: U.S. Army Medical Research and Development Command. Report No. 205. Available from DTIC. AD-A164696. Sax NI, Lewis RJ. 1987. Hawley's Condensed Chemical Dictionary, llth Ed. New York, NY: Van Nostrand Reinhold Company. Weast RC. 1988. CRC Handbook of Chemistry and Physics. 69th Ed. Boca Raton, FL: CRC Press, Inc. Windholz M, Budavari S, Blumetti RF, Otterbein ES, eds. 1983. The Merck Index -- An Encyclopedia of Chemicals, Drugs, and Biologicals. 10th Ed. Rahway, NJ: Merck and Company, Inc., p. 158. -7- ------- |