TOXICOLOGICAL PROFILE FOR
FARNESOL
Criteria and Standards Division
Office of Drinking Water
U.S. Environmental Protection Agency
Washington, DC 20460
June, 1989
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TOXICOLOGICAL PROFILE
FOR
FARNESOL
June 1989
Criteria and Standards Division
Office of Drinking Water
U.S. Environmental Protection Agency
Washington, DC 20460
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FARNESOL
A. GENERAL
1. CAS Number: 4602-84-0
2. RTECS Number: JR4979000
3. General Name/Svnonvms: 3,7,ll-Trimethyl-2,6,10-dodecatrien-l-ol
4. Molecular Formula: C15H260
5. Molecular Weight; 222.36
6. Structure:
B. PHYSICAL AND CHEMICAL PROPERTIES
1. State: Colorless liquid Sax and Lewis (1987)
2. Vaoor Pressure: No information was found.
3. Melting Point: No information was found.
4. Boiling Point; 111°C at 0.35 mmHg Windholz (1983)
5. Specific Gravity: 0.885 at 15°C Sax and Lewis (1987)
6. Solubility; Soluble in three volumes Sax and Lewis (1987)
of 70% alchohol
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7. Loo Kt...: No information was found.
8. UV Absorption: UVmax = 192-196 nm (z28,500) Windholz et al. (1983)
C. PHYSICAL/CHEMICAL EQUILIBRIUM FACTORS
1. Bioconcentration Factors (BCF); No information was found.
2. Kwa: No information was found.
3. KOJ: No information was found.
D. ENVIRONMENTAL FATE
1. Photolysis: No information was found.
2. Leaching: No information was found.
3. Route of Water Contamination: No information was found.
4. Hydrolysis: No information was found.
5. Plant Uptake; No information was found.
6. Microbial Degradation: No information was found.
7. Persistence in Soil/Water: No information was found.
8. Byproducts; No information was found.
9. Vaporization: No information was found.
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E. ACUTE TOXICITY IN MAMMALS
Animal/strain/sex
Mouse/-7-
Rat/-/-
Route LD
Oral
Oral
Intraperitoneal
Intraperitoneal
Oral
Intraperitoneal
so (mg/kg)
>12,000b
7,400C
2,950"
443C
>10,000b
>6,000C
Reference
Binet et al . (1972)
"Data not provided.
"Administered as solution.
'Administered as suspension.
F. SKIN AND EYE IRRITATION AND SENSITIZATION IN MAMMALS
No information was found.
G. SUBCHRONIC TOXICITY IN MAMMALS
No information was found.
H. REPRODUCTIVE EFFECTS AND TERATOGENICITY IN MAMMALS
No information was found.
I. MUTAGENICITY/GENOTOXICITY
Data are presented in tabular form on page 4.
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MUTAGENICITY/GENOTOXICITY
Test
Strain
Dose/concent rat i on
Toxic effects
Reference
DNA synthesis
Cutex molestus
ovary cells
ID'4 M
Inhibited DNA
synthesis; cell
morphology changes
Himeno et al. (1979)
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J. CHRONIC TOXICITY/CARCINOGENICITY
No Information was found.
K. PHARMACOKINETICS IN MAMMALS
No Information was found.
L. HUMAN HEALTH EFFECTS
No information was found.
M. EXISTING STANDARDS/CRITERIA
No information was found.
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N. REFERENCES
Binet L, Binet P, Mocave M, Morin H, Pechery C, Roux M. 1972. Le Farnesol,
substance psycho-sedative et spasmolytique. Therapie 27:893-905.
Himeno M, Takahashi J, Komano T. 1979. Effect of juvenile hormone on
macromolecular synthesis of an insect cell line. Agric. Biol. Chem.
43(6):128-1292.
Sax NI, Lewis RJ Sr. 1987. Hawley's Condensed Chemical Dictionary, llth Ed.
New York, NY: Van Nostrand Reinhold Company, p. 307.
Windholz M, Budavari S, Blumetti RF, Otterbein ES, eds. 1983. The Merck
Index -- An Encyclopedia of Chemicals, Drugs, and Biologicals. 10th Ed.
Rahway, NJ: Merck and Company, Inc., p. 568.
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