TOXICOLOGICAL PROFILE FOR
FARNESOL
Criteria and Standards Division
Office of Drinking Water
U.S. Environmental Protection Agency
Washington, DC  20460
June, 1989

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       TOXICOLOGICAL  PROFILE

                 FOR

              FARNESOL
             June  1989
   Criteria  and  Standards  Division
      Office of Drinking Water
U.S. Environmental Protection Agency
       Washington, DC   20460

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                                       FARNESOL


A.  GENERAL


    1.  CAS Number:   4602-84-0


    2.  RTECS  Number:   JR4979000


    3.  General  Name/Svnonvms:  3,7,ll-Trimethyl-2,6,10-dodecatrien-l-ol


    4.  Molecular Formula:   C15H260


    5.  Molecular Weight;   222.36


    6.  Structure:
B.  PHYSICAL AND CHEMICAL PROPERTIES


    1.  State:   Colorless liquid                          Sax and Lewis (1987)

    2.  Vaoor Pressure:   No information was found.


    3.  Melting Point:   No information was found.


    4.  Boiling Point;   111°C at 0.35 mmHg                Windholz (1983)


    5.  Specific Gravity:  0.885 at 15°C                  Sax and Lewis (1987)


    6.  Solubility;   Soluble in three volumes             Sax and Lewis (1987)
                     of 70% alchohol
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    7.  Loo Kt...:  No information was found.





    8.  UV Absorption:  UVmax =  192-196  nm  (z28,500)        Windholz et al.  (1983)








C.  PHYSICAL/CHEMICAL EQUILIBRIUM FACTORS





    1.  Bioconcentration  Factors  (BCF);  No  information  was found.





    2.  Kwa:   No information was found.





    3.  KOJ:   No information was found.








D.  ENVIRONMENTAL  FATE





    1.  Photolysis:   No information was found.





    2.  Leaching:   No information was found.





    3.  Route of Water  Contamination:  No  information was found.





    4.  Hydrolysis:   No information was found.





    5.  Plant Uptake;  No information was  found.





    6.  Microbial  Degradation:   No information  was found.





    7.  Persistence in  Soil/Water:  No  information was found.





    8.  Byproducts;   No information was found.





    9.  Vaporization:  No information was  found.
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E.  ACUTE TOXICITY IN MAMMALS
Animal/strain/sex
Mouse/-7-



Rat/-/-

Route LD
Oral
Oral
Intraperitoneal
Intraperitoneal
Oral
Intraperitoneal
so (mg/kg)
>12,000b
7,400C
2,950"
443C
>10,000b
>6,000C
Reference
Binet et al . (1972)





"Data  not  provided.
"Administered as solution.
'Administered as suspension.

F.  SKIN AND EYE IRRITATION AND SENSITIZATION IN MAMMALS

     No information was found.
G.  SUBCHRONIC TOXICITY IN MAMMALS
     No information was found.
H.  REPRODUCTIVE EFFECTS AND TERATOGENICITY IN MAMMALS
     No information was found.
I.  MUTAGENICITY/GENOTOXICITY

     Data are presented in tabular form on page 4.
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    MUTAGENICITY/GENOTOXICITY
   Test
                               Strain
                                     Dose/concent rat i on
                             Toxic  effects
                                                                                                                               Reference
DNA synthesis
Cutex molestus
ovary cells
ID'4 M
Inhibited DNA
synthesis; cell
morphology changes
Himeno et al. (1979)

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J.  CHRONIC TOXICITY/CARCINOGENICITY





     No Information was found.








K.  PHARMACOKINETICS IN MAMMALS





     No Information was found.








L.  HUMAN HEALTH EFFECTS





     No information was found.








M.  EXISTING STANDARDS/CRITERIA





     No information was found.
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N.   REFERENCES

Binet L, Binet P, Mocave M, Morin H, Pechery C, Roux M.  1972.  Le Farnesol,
substance psycho-sedative et spasmolytique.  Therapie 27:893-905.

Himeno M, Takahashi J, Komano T.  1979.  Effect of juvenile hormone on
macromolecular synthesis of an insect cell line.  Agric. Biol. Chem.
43(6):128-1292.

Sax NI, Lewis RJ Sr.  1987.  Hawley's Condensed Chemical Dictionary, llth Ed.
New York, NY:  Van Nostrand Reinhold Company, p. 307.

Windholz M, Budavari S, Blumetti RF, Otterbein ES, eds.  1983.  The Merck
Index -- An Encyclopedia of Chemicals, Drugs, and Biologicals.  10th Ed.
Rahway, NJ:  Merck and Company, Inc., p. 568.
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