TOXICOLOGICAL PROFILE FOR FARNESOL Criteria and Standards Division Office of Drinking Water U.S. Environmental Protection Agency Washington, DC 20460 June, 1989 ------- TOXICOLOGICAL PROFILE FOR FARNESOL June 1989 Criteria and Standards Division Office of Drinking Water U.S. Environmental Protection Agency Washington, DC 20460 ------- FARNESOL A. GENERAL 1. CAS Number: 4602-84-0 2. RTECS Number: JR4979000 3. General Name/Svnonvms: 3,7,ll-Trimethyl-2,6,10-dodecatrien-l-ol 4. Molecular Formula: C15H260 5. Molecular Weight; 222.36 6. Structure: B. PHYSICAL AND CHEMICAL PROPERTIES 1. State: Colorless liquid Sax and Lewis (1987) 2. Vaoor Pressure: No information was found. 3. Melting Point: No information was found. 4. Boiling Point; 111°C at 0.35 mmHg Windholz (1983) 5. Specific Gravity: 0.885 at 15°C Sax and Lewis (1987) 6. Solubility; Soluble in three volumes Sax and Lewis (1987) of 70% alchohol -1- ------- 7. Loo Kt...: No information was found. 8. UV Absorption: UVmax = 192-196 nm (z28,500) Windholz et al. (1983) C. PHYSICAL/CHEMICAL EQUILIBRIUM FACTORS 1. Bioconcentration Factors (BCF); No information was found. 2. Kwa: No information was found. 3. KOJ: No information was found. D. ENVIRONMENTAL FATE 1. Photolysis: No information was found. 2. Leaching: No information was found. 3. Route of Water Contamination: No information was found. 4. Hydrolysis: No information was found. 5. Plant Uptake; No information was found. 6. Microbial Degradation: No information was found. 7. Persistence in Soil/Water: No information was found. 8. Byproducts; No information was found. 9. Vaporization: No information was found. -2- ------- E. ACUTE TOXICITY IN MAMMALS Animal/strain/sex Mouse/-7- Rat/-/- Route LD Oral Oral Intraperitoneal Intraperitoneal Oral Intraperitoneal so (mg/kg) >12,000b 7,400C 2,950" 443C >10,000b >6,000C Reference Binet et al . (1972) "Data not provided. "Administered as solution. 'Administered as suspension. F. SKIN AND EYE IRRITATION AND SENSITIZATION IN MAMMALS No information was found. G. SUBCHRONIC TOXICITY IN MAMMALS No information was found. H. REPRODUCTIVE EFFECTS AND TERATOGENICITY IN MAMMALS No information was found. I. MUTAGENICITY/GENOTOXICITY Data are presented in tabular form on page 4. -3- ------- MUTAGENICITY/GENOTOXICITY Test Strain Dose/concent rat i on Toxic effects Reference DNA synthesis Cutex molestus ovary cells ID'4 M Inhibited DNA synthesis; cell morphology changes Himeno et al. (1979) ------- J. CHRONIC TOXICITY/CARCINOGENICITY No Information was found. K. PHARMACOKINETICS IN MAMMALS No Information was found. L. HUMAN HEALTH EFFECTS No information was found. M. EXISTING STANDARDS/CRITERIA No information was found. -5- ------- N. REFERENCES Binet L, Binet P, Mocave M, Morin H, Pechery C, Roux M. 1972. Le Farnesol, substance psycho-sedative et spasmolytique. Therapie 27:893-905. Himeno M, Takahashi J, Komano T. 1979. Effect of juvenile hormone on macromolecular synthesis of an insect cell line. Agric. Biol. Chem. 43(6):128-1292. Sax NI, Lewis RJ Sr. 1987. Hawley's Condensed Chemical Dictionary, llth Ed. New York, NY: Van Nostrand Reinhold Company, p. 307. Windholz M, Budavari S, Blumetti RF, Otterbein ES, eds. 1983. The Merck Index -- An Encyclopedia of Chemicals, Drugs, and Biologicals. 10th Ed. Rahway, NJ: Merck and Company, Inc., p. 568. -6- ------- |