United SIMM
4>EPA
           Agency
           Offlcaof
           PMicidM and
           Washington OC 20460
                                    December 1986
Guidance for the
Reregistration of
Pesticide Products
Containing
Potassium permanganate
as the Active Ingredient


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          GUIDANCE FOR THE
REREGISTRATION OF PESTICIDE PRODUCTS

             CONTAINING
       POTASSIUM PERMANGANATE
      AS THE ACTIVE INGREDIENT
          CASE NUMBER 0220


    ENVIRONMENTAL PROTECTION AGENCY

    OFFICE OF PESTICIDE PROGRAMS

      WASHINGTON, D.C.  20460

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                        TABLE OF CONTENTS
                                                               Page
      Introduction 	  1

I.    Regulatory Assessment  	  4

II.   Requirement for Submission of Generic Data	37

III.  Requirement for Submission of Product-Specific
      Data	  40

IV.   Submission of Revised Labeling 	  40

      A.  Label Contents	41

      B.  Collateral Information 	  46

V.    Instructions for Submission	47

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                           APPENDICES
                                                              Page

II-l     Guide to Bibliography	50

II-2     Bibliography	52

II-3     FIFRA §3(c)(2)(B) Summary Sheet - EPA Form 8580-1 .  .  53

II-4     Certification of Attempt to Enter Into an Agreement
          with Other Registrants for Development of Data
          EPA Form 8580-2	54

III-l      Product Specific Data Report (End-Use Products) .  .  55

IV-1       40 CFR 162.10 Labeling Requirements 	  57

IV-2       Table of Labeling Requirements	66

IV-3       Physical/Chemical Hazards Labeling Statement. ...  69

IV-4       Storage and Disposal Instructions 	  70
                                ii

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                          (1)
                         INTRODUCTION

     The Federal Insecticide, Fungicide, and Rodenticide Act
(FIFRA sec. 3(g)) directs EPA to reregister all pesticides as
expeditiously as possible.

     To carry out this task, EPA has established the Regis-
tration Standards program, which will review all pesticide
products containing active ingredients first registered before
January 1, 1977.  Pesticides will be reviewed in use clusters
which have been ranked to give earliest review to pesticides
used on food and feed crops.

     The Registration Standards program involves a thorough
review of the scientific data base underlying pesticide
registrations and an identification of essential but missing
studies which may not have been required when the product
was initially registered or studies that are now considered
insufficient.  EPA's reassessment results in the development
of a regulatory position, contained in a Registration Standard,
on each pesticide and its uses.  The Agency may require the
registrant to modify product labels to provide additional
precautionary statements, restrict the use of the pesticide
to certified applicators, provide reentry intervals, modify
uses or formulation types, specify certain packaging limitations,
or other requirements to assure that proper use of the pesticide
will not result in adverse effects on the environment.

     The scientific review, which is not contained in this
Guidance Package but is available upon request, concentrates
on the technical grade of the active ingredient and identifies
missing generic data.  However, during the review of these
data we are also looking for potential hazards that may be
associated with the end use (formulated) products that contain
the active ingredient. If we have serious concerns, we will
address end use products as part of the Registration Standards
program and will propose regulatory actions to the extent neces-
sary to protect the public.

     EPA has the authority under FIFRA sec. 3(c)(2)(B') to
require registrants to submit data that will answer our
questions regarding the hazard that may result from the
intended use of a pesticide.  Although sec. 3(c)(2)(B) provides
that all registrants are responsible for these data, the
Agency generally imposes generic data requirements only on the
registrants of the manufacturing use products (basic suppliers

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                              (2)
of the active  ingredient) and other producers who do not
qualify for the formulator's exemption.*

     A producer who wishes to qualify  for the formulator's
exemption may  change his source of supply to a registered
source, provided the source does not share ownership in
common with the registrant's firm.  A  registrant may do so
by submitting  a new Confidential Statement of Formula, EPA
Form 8570-4, identifying the registered source of the active
ingredient, to the appropriate Product Manager within 90
days of receipt of this Guidance Document.  The chart on the
following page shows what is generally required of those who
do and do not  qualify  for the formulator1s exemption in the
Registration Standards program.

     If you decide to  request the Agency to cancel the regis-
tration of any of your products subject to the requirements
of this Guidance Document, please notify the Product Manager
named in the cover letter, within 90 days from the receipt
of this document.  If  you decide to maintain your product
registration(s), you must provide the  information described in
the following  pages within- the time frames outlined. EPA will
issue a notice of intent to cancel or  suspend the registration
of any currently registered product which does not comply
with the requirements  set forth in this Guidance Document.

    You are reminded that FIFRA sec. 6(a)(2) requires you to
submit tactual information raising concerns ot possible
unreasonable adverse effects of a pesticide. You should
notify the Agency of interim results of studies in progress
if those results show  possible adverse effects.
*The formulator's exemption applies  to a registrant of an
product  if  the  source  of  his  active  ingredient(s): (1) is a
registered  product  and (2)  is  purchased from a source which
does not have ownership in  common  with the registrant's
firm.

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                         (3)
 "PRODUCTS SUBJECT TO THE
  REGISTRATION STANDARDS  PROGRAM
  ACTION(S) REQUIRED TO
  MAINTTAIN REGISTRATION
I. Products That Do Not Qualify
   For The Formulator's Exemption

   A. Single Active Ingredient
      Products*
These products must be reregis-
tered. To obtain reregistration
labeling, packaging and data
requirements must be satisfied
in accordance with the Regis-
tration Standards Guidance
Docume nt.
   B. Multiple Active Ingredient
      Products
These products will not be
reregistered at this time.
However, generic data required
to continue the registration of
the active ingredient under
review, as described in the
Registration Standards Guidance
Document, will be required and
some labeling precautions may
also be required.
II.  Products That Do Qualify For
     The Formulator's Exemption
Only when additional restric-
tions or labeling are  needed to
protect man or the environment
will these products be subject
to the Registration Standard
requirements. Affected products
will be dealt with in  a variety
of ways, including but not
limited to the Label Improvemen
Program and special intent
to cancel notices.
* End use products of registrants who also produce a manufacturing
use product will not be required to be reregistered provided that
registrant fulfills the requirements specified in the Guidance
Document for manufacturing use product(s). Such end use products
will be subject to the labeling changes required for products in "II"
above. If there are no manufacturing use products registered by any
company end use products will be required to be reregistered.

NOTE: If all registrants in "I" above fail to meet the requirements  :
I-A and B above, then the registrants in "II" lose their right to
qualify for the formulator's exemption and become subject to the
requirements in I-A and B.                    	

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                            (4)
                    REGULATORY ASSESSMENT

     A.  INTRODUCTION

     This  registration standard  describes  the  regulatory
position and  rationale of  the Environmental  Protection
Agency  ("The  Agency")  based  upon an  evaluation of  the
registered  products  which  contain potassium  permanganate
and their  uses.   It  should be noted  that there is  no
registered  manufacturing use product (MUP) for this
chemical;  potassium  permanganate,  however, is  commercially
available  in  several grades  from domestic  and  foreign com-
panies.  This  standard addresses end-use products  containing
potassium  permanganate and manufacturing-use products (in
the event  a prospective registrant wishes  to register
potassium  permanganate as  an MUP).

     Future requests for registration of substantially
similar products  will  be covered by  this standard.
Dissimilar  products  must be  evaluated In order to  be
registered.   If new  products are proposed  with disimilar
use patterns,  formulation  type,  precautionary  statments,
etc., the  standard will be amended accordingly.  After
briefly describing the chemical  and  its uses,  this chapter
presents the  regulatory position and rationale, the criteria
for registration, acceptable ranges  and Halts, and labeling
considerations.

     In developing its regulatory  position,  the Agency
determines whether available data  indicate that a  pesticide
has met the criteria for unreasonable adverse effects of
Section 162.11(a) of Title 40 of the U.S.  Code of  Federal
Regulations (CFR).   Pesticides meeting these criteria are
candidates  for a  Special Review,  an  intensive risk/benefit
analysis.  The Agency's determination as to whether any
criteria have  been met and its rationale for any regulatory
action are summarized  in the regulatory position/rationale
section of this standard.

     B. DESCRIPTION  OF THE CHEMICAL

     Potassium permanganate  (KMn04>  Is the potassium salt
of permanganic acid.   A "common  name" has  not been established
by the American National Standards Institute, Inc. (ANSI)
or other official organizations  concerned with the nomenclature
of pesticides.  Therefore  the  chemical will be referred to
by its chemical name,  "potassium permanganate".  The Chemical
Abstract Service  Registry  Number (CAS) is  7722-64-7 and the
Agency's Chemical Code Number  is  068501.

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                            (5)
     Potassium permanganate in its pure form is  a
crystalline dark purple granular material.   Potassium
permanganate is thermally unstable.  When heated, it
begins to decompose with the evolution of oxygen at ca
240°C.  Potassium permanganate is decomposed by  organic
solvents (e.g., alcohols) and reducing substances (e.g.,
iodate, oxalate, and ferrous salts), especially  under
acidic conditions.  In water, potassium permanganate is
very soluble (i.e., 6.38 gm/100ml at 20°C and 25 gin/100ml
at 65°C).

     Potassium permanganate is an oxidant disinfectant
which is effective against a broad spectrum of microorganisms.
It is registered as a bactericidal, fungicidal,  and algaecidal
agent in coaling towers, evaporation condensers, air wash
systems, ornamental ponds, fountains, and aquaria.  Other
uses include treatment of potable and poultry drinking water;
and disinfection and sanitization of equipment in dairies
and food processing plants (see the "EPA Pesticide Index"
for a description of all uses).

     There are twenty one registered products containing
potassium permanganate, four of which are intrastate
registrations.  This standard applies to all those products
in which potassium permanganate is the single active ingre-
dient.  Potassium permanganate is registered as  the single
active Ingredient in eight products, and in combination with
other active ingredients in nine products.  The  multiple
active ingredient products include one or more of the follow-
ing ingredients: sodium hypochlorite, sodium carbonate,
and/or sodium phosphate; the standard does not apply to these
products.

     C. REGULATORY POSITION AND RATIONALE

     Based on a review and evaluation of all available  data
submitted to EPA and other relevant information  on potassium
permanganate, the Agency has made the following  determinations:

      1. Based on available data, the Agency is declaring
        Potassium Permanganate as an inert ingredient at
        concentrations of  1.0% or less and in combination
        with an active ingredient (including sodium hypo-
        chlorite, sodium carbonate and sodium phosphate).

        Rationale; DataJ^/ available to the Agency indicate
        that potassium permanganate at concentrations of
         1.0% or less does not have any antimicrobial
y Smith, M.K.:  "Qualitative Use Assessment (QUA) for
   Potassium Permanganate (068501) as a Bactericidal
   Agent."  Science Support Branch, Benefits and Use
   Division (EPA/OPP), November, 1984.

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                     (6)
activity.  The potassium  permanganate present in
the multiple  ingredient products cited in this
standard functions simply as a color indicator,
imparting a pink color to the use solution; once
the solution  becomes colorless it should be discarded.

When diluted  as recommended, the sodium hypochlorite
present in these products provides "available chlorine'
in the form of hypochlorous acid at concentrations
ranging between 50-200 ppm.  The available chlorine
is the antimicrobial agent responsible for bacteri-
cidal activity in these products.

Hence, registrants with multiple active ingredient
registrations described above must submit amendments
and revised labels removing potassium permanganate
as an active  ingredient from their label ingredient
statement no  later than 6 months from the issuance
date of this  standard, or their products may be
subject to enforcement action .  When these regis-
trations have been amended, these products will no
longer be subject to this standard.  However, they
wil.l be subject to a standard dealing with the
active ingredient as listed on the revised label.

Alternatively, those registrants who select to retain
1% or less potassium permanganate as an active
ingredient In the ingredient statements must submit
documentation of efficacy at the claimed concentra-
tion using  potassium permanganate alone.  Products
documenting and listing potassium permanganate as
as active Ingredient will be subject to this stand-
ard.  If they fail to convince the Agency of the
efficacy of potassium permanganate in their product,
they must amend their registration to remove potas-
sium permanganate from their label ingredient
statement as  an active ingredient, or face possible
enforcement action.

One of the registered uses of potassium permanganate
includes use  in poultry drinking water as a sanitizer
(Reg. No. 5587-49).  This use would be expected to
cause minute  residues of  manganese (in a combined
form) in poultry and eggs.  Under the Federal
Food, Drug and Cosmetic Act (FFDCA), a tolerance or
an exemption  from the requirement of a tolerance
is required for such residues in poultry and eggs.
The Agency is requiring that the registrant peti-

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   tioQ Che  Agency for an exemption from Che require-
   ment of  a tolerance.

   Rationale;   Manganese has been demonstrated to be
   an essential trace element In animals and man.
   In the  Agency's view, exemption from the requirement
   of a tolerance for residues of manganese in poultry
   and eggs, resulting from the registered use of
   potassium permanganate as a sanitizer in poultry
   drinking  water, would be appropriate for the reasons
   noted herein.   Naturally occurring manganese is
   usually  in  the +2, +3 or +4 valence state.  Because
   of the  reactivity of  permanganate ion, any resulting
   residues  of manganese in poultry or eggs would
   involve  lower  (naturally occurring) valence states.
   The poultry drinking  water sanitizer provides 2.8
   to 5.5  ppm  permanganate ion when diluted. This
   use essentially doubles the daily intake of manganese
   by the  chicken (estimated 0.08 0.1 mg/day).
   Because  of  excretion  and little uptake of manganese
   from the  gut,  very little manganese is expected to
   be retained by the chicken; and since the average
   person  in this country currently ingests 2.3 to
   3.8 mg  of manganese daily, the additional amount
   resulting from this use would be minute, and not a
   matter  of concern.

3.  There are two  potassium permanganate products
   registered  for use in treating human drinking
   water (Reg. No. 8429-6, 8429-7).  The Agency has
   determined  that such  potassium permanganate products
   must bear labeling directions which would limit the
   residues  of manganese in the finished potable
   water to  not more than 0.05 mg/1.

   Rationale;  The level  of 0.05 mg/1 has been estab-
   lished  in the  National Secondary Drinking Water
   Regulations as the recommended level for manganese
   in drinking water. Consistent with that regulation,
   the Agency  is  requiring the labels of potassium perman-
   ganate  products for potable water treatment to limit
   residues  of manganese in the finished potable water
   to not  more than 0.05 mg/1 (equivalent Co ca 0.23
   ppm potassium permanganaCe).

4.  Technical potassium permanganate and manufacturing-
   use products containing potassium permanganate are
   being placed in Toxiclty Category I on the basis of
   eye and dermal corrosivity.  They are subject to
   Toxicity  Category I precautionary labeling.

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                    (8)
Rationale;  In Che case of potassium permanganate,
the technical and manufacturing-use products are
identical (i.e., at least 99.SZ KMn04>.  Sufficient
data are available to show that technical potassium
permanganate is corrosive to the eye and skin.  In
an eye irritation study using rabbits, 10 mg was
applied to each eye, and after 168 hours, all the
rabbits showed the maximum possible ocular score.
In a primary dermal irritation study, 0.5 gram
samples (moistened) were placed in contact with the
rabbit's skin for 24 hours.  After 24 hours, destruc-
tion of the skin was observed, with ulcerations
into the peritoneal cavity.  The damage was accom-
panied by hemorrhage.  Due to the ocular and dermal
reactions, potassium permanganate is placed in
Toxicity Category I.  The precautionary label
language which accompanies Toxicity Category I
(§162.10 of 40 CFR) therefore applies to these pro-
ducts for these routes of exposure.

The available toxicology data adequately define the
acute toxicity of the compound.  Based on considera-
tions regarding the chemical reactivity of the
permanganate ion and the ubiquity of manganese,
there are no chronic or subchronlc coxicity data
requirements.  However, to support each end-use
product, each registrant must submit or cite valid
acute toxicity data for each formulation.

Rationale;  Sufficient data are available to show
that technical potassium permanganate is corrosive
to the eye and skin, and subject to Toxicity
Category I and its accompanying precautionary
labeling.  The Agency also has data to satisfy the
requirements for acute oral toxicity of the technical
compound.  As none of the compound's currently
registered uses would result in any significant
inhalation exposure, an acute inhalation toxicity
study is not required.  Finally, since potassium
permanganate is not an organophosphate and does
not inhibit cholinesterase, a delayed neurotoxicity
study is not required.  Thus, additional acute
toxicology studies are not required for the technical
grade of potassium permanganate.

Human and animal exposure to or contact with potassium
permanganate results in reduction of the permanganate
ion to the lower (naturally occurring) valence
states.  As natural manganese in these lower valence
states is ubiquitous and dietary exposure to manganese
residues resulting from use of products with potassium

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                      (9)
   permanganate is  not a matter of  concern,  chronic
   and subchronic toxicity studies  are not  necessary
   or appropriate for potassium permanganate based
   upon the manganese residues from products containing
   potassium permanganate.

   Before the Agency will register  or reregister end-use
   products (EPs) containing potassium permanganate,
   registrants must submit or cite  acute toxicity data
   (oral, dermal skin irritation and eye irritation)
   specific to the  particular EPs.   This is  required
   to establish the acute toxicity  categories for those
   potential routes of exposure, and thus enable the
   Agency to prescribe appropriate  precautionary state-
   ments in accordance with Section 162.10  of 40 CFR.

6.  Data on the environmental fate of potassium
   permanganate are being required  as outlined in the
   data tables.

   Rationale;  No data are available to assess the
   environmental fate of potassium  permanganate.
   When the required data are submitted, the behavior
   of the chemical  in the environment will  be assessed.
   Further regulatory requirements  may be indicated
   based on that review.

7.  The wildlife and aquatic organisms data  requirements
   are only partially fulfilled.  Hence, the Agency
   could not fully  assess the toxicity of potassium
   permanganate to  nontarget organisms.  When the
   additional data  outlined in the  data tables are
   submitted, a full assessment will be made.

   Rationale; The only available wildlife studies show
   that the technical grade of potassium permanganate
   is moderately toxic to warmwater fish species.
   Additional studies are required  to establish the
   toxicity to avian species (LC5o's), and  the toxicity
   to a cold water  fish and fresh water invertebrates
   (LC5o's).  If the required cold  water fish LCso value
   is less than 1 ppm, all labeling will be  changed to
   include the statement "This Pesticide is  Toxic to
   Fish".

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                             (10)
     8. There is a possibility of contamination of groundwater
        by potassium  permanganate.  The data currently
        available to  the Agency do not adequately charac-
        terize this potential.

        Rationale: Because of the nature of some uses of
        potassium permanganate (i.e., water treatment com-
        pound; see Pesticide Index for uses) groundwater
        contamination may be possible.  The submission of
        the required  environmental fate data for the tech-
        nical grade of the active ingredient will enable
        the Agency to more fully address this issue.

     9. Potassium permanganate is not being classified for
        Restricted Use.

        Rationale;  Available data do not show that any of
        the risk criteria listed in 162.11(a) of Title 40
        of the U.S. Code of Federal Regulations have been
        met or exceeded for the uses of potassium permanganate
        specified in  this standard to warrant restriction
        of these uses.

    10. EP's containing potassium permanganate may be
        registered for sale, distribution and use, subject
        to the terms  and conditions specified in this
        standard.

        Rationale;  Under FIFRA, the Agency normally does
        not cancel or withhold registration because data
        are missing or inadequate (for example, see Section
        3(c)(2)(B) and 3(c)(7) of FIFRA).  Issuance of this
        standard provides a mechanism for identifying data
        needs for registration under the standard and time
        frames for generating the data.  Labeling modifica-
        tions are also required within a specified time.
        These data will be reviewed and evaluated when they
        are received  and the Agency will determine at that
        time if they  will affect the registration of potas-
        sium permanganate.

     D. CRITERIA FOR  REGISTRATION UNDER THIS STANDARD

     Manufacturing use and end use products which are subject
to this standard, must meet the following conditions along
with the others noted in this standard:

     1. Contain potassium permanganate as the sole active
        ingredient, and

     2. Bear required labeling as set forth in the Required
        Labeling section of this standard.

     3. Conform to the acute toxlcity limits, product

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        composition,  and use pattern requirements listed
        in the Acceptable Ranges and Limits section of
        this document*

     The applicant for  registration or reregistration of
products subject to this standard must comply with all
terms and conditions  described in it, including a commitment
to fill data gaps on  the schedule required by this Agency.
All applicants for registration under this standard must
follow the instructions contained in this standard and
complete and submit the appropriate forms and information
within the time specified.

     E. ACCEPTABLE RANGES AND LIMITS
        1.  Product Composition Standard

           End-use products proposed for registration under
           this standard must be substantially similar to
           the formulations approved for potassium perman-
           ganate.  A product will be considered substan-
           tially similar to a registered product if it
           contains the same active Ingredients at approxi-
           mately the same concentrations.  End-use for-
           mulations must contain potassium permanganate as
           the sole active Ingredient in the following
           percentages:

           a. Pelleted/Tableted EPs must contain at least
              40 percent potassium permanganate.

           b. Liquid EPs must contain at least 1.2 percent
              potassium permanganate.

           c. Powder EPs must contain at least 41 percent
              potassium permanganate.

           d. Crystalline EPs must contain at least 95.00
              percent potassium permanganate.

           Applicants who wish to register an end-use pro-
           duct differing In composition from those stated
           above, must satisfy whatever additional data
           requirements apply to such modifications.  If
           such products are registered, the Agency will
           amend the standard to Include such products.
           Each EP formulation proposed for registration
           must be fully described with an appropriate
           certification of limits, stating maximum and
           minimum amounts of the active ingredient which
           may be present in products.

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                             (12)
         2. Acute  Toxicity  Limits

           The Agency  will consider  for  registration  MUPs
           and EPs  provided the  product  is  supported  by
           toxicity  data and  the  labeling for  the  product
           bears  appropriate  precautionary  statements,
           consistent  with the acute  toxicity  categories
           under  Section  162.10  of 40 CFR.

         3. Use Patterns

           To be  registered under  this standard, EPs  con-
           taining  potassium  permanganate may  be labeled
           for use  as  a bactericidal,  fungicidal and
           algaecidal  agent in cooling towers,  evaporative
           condensers, air wash  systems  and ornamental
           ponds, fountains,  aquaria,  and potable  and
           poultry  drinking water, as  applicable.

     F. REQUIRED  LABELING

     Although there  are no registered  MUPs  of  potassium
permanganate, any future MUP  registrations  and  all EPs
must bear appropriate  labeling as  specified in  40  CFR
162.10, in addition  to the following  specific  labeling
requirements.

     1. Use Pattern  Statement

        All Mups  must  state that  they  are intended only
        for formulation into  end-use  products  for  any of
        the use patterns listed  in section  3 of Acceptable
        Ranges and Limits.  A limiting factor will be the
        data that support  each use pattern.  No use may be
        included  on  the label where  the  registrant(s)
        fail(s) to agree to comply with  data requirements
        in either TABLE A  or  TABLE B  (and subtables)  for
        that use  pattern.

     2. Precautionary  Statements

        a. All end-use products intended for uses
           where  there is  likelihood  for point  source
           discharge (i.e., cooling  towers, ornamental
           ponds, fountains,  and  potable and poultry
           drinking  water)  must bear  the following state-
           ment:

           "Do not discharge  effluent containing this
           product  into lakes, ponds, streams,  estuaries,
           oceans or public water unless this product is

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                             (13)
           specifically  identified and addressed in an  NPDES
           permit.  Do not discharge effluent containing
           this product  into sewer systems without previously
           notifying  the sewage treatment plant authority.
           For guidance  contact your State Water Board  or
           Regional Office of the EPA."

           The statement "This Pesticide is Toxic to Fish-
           is not required at this time.  The toxic to  fish
           statement  is  only required on labeling when  the
           fish acute LCso value is 1 ppm or less.  Potassium
           permanganate's LCso value for warm water fish
           species is 2.3 to 3.6 ppm.  If the required  cold
           water fish LC5Q value is Ippm or less, all labeling
           will be changed to include the "toxic to fish"
           statement.

        b. All end-use products Intended for uses
           where there is likelihood for point source
           discharge  (i.e., cooling towers, ornamental
           ponds, fountains, and potable and poultry
           drinking water) must bear the statement:

           "Do not contaminate water by cleaning of equip-
           ment of disposal of waste."

        c. All future MUPs must bear the statement:

           "Corrosive to eyes and skin" and the signal
           word "DANGER".

     3. Use Directions

        There are two potassium permanganate products
        registered for use in treating human drinking
        water (Reg.  No. 8429-6,  8429-7).  The Agency has
        determined that such potassium permanganate pro-
        ducts must bear approved labeling directions which
        would limit  the residues of manganese in the finish-
        ed potable water to not  more than 0.05 mg/1.

     G. TOLERANCE REASSESSMENT

     Under the Federal Food,  Drug and Cosmetic Act (FFDCA),
a tolerance or an exemption from the requirement of a
tolerance is  required for the residues of manganese in
poultry and eggs (which result from the poultry drinking
water use pattern).   The Agency  is requesting that the
registrant petition  the Agency for an exemption from the
requirement of a tolerance (see  Regulatory Position and
Rationale No. 2).

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                                              (!•*)
                                  EPA  Index  Co Pesticide Chemicals

a068501                                 POTASSIUM  PERMANGANATE

            TYPE PESTICIDE:  Antimicrobial,  Algaecide, Fungicide and Insecticide

            FORMULATIONS;
            PTT(40%, 80%)
            Cr   (95.64%, 98%)
            SC/S (41%)
            RTU  (1.2%,  2.5%)

            PRESENTATION OF  INFORMATION:   Whenever  possible, final concentrations are
            expressed in parts  per million or ounces  total active ingredient(s).  Con-
            centrations are  rounded  to the nearest  whole number when the value is less
            than 1,000 and to the third significant figure when the value is greater
            than 1,000.  Unless otherwise  stated, the dilutions are the ratio of the
            volume of the product to be diluted to  the volume of fluid in which the
            product is diluted.

            GENERAL WARNINGS AND LIMITATIONS;  Potassium permanganate causes severe
            burns of eyes, skin and mucous membranes.                     Contact with
            combustible material may cause fire or  explosion.

            This product is  toxic to fish.   Do not  discharge into lakes, streams, ponds
            or public waters unless  in accordance with an NPDES Permit.  Strong oxidiz-
            ing agent.  Mix  only with  water.  Use clean, dry utensils.  Contamination
            with moisture, organic matter, or other chemicals may start a chemical re-
            action, with generation  of heat, liberation of hazardous gases, and possi-
            ble generation of fire and explosion.

            Apply only as specified  on the label  and  technical data sheets.

            Read label very  carefully  for  specific  warnings, human toxicity statements
            and environmental causes.

            Follow  label directions  for the  disposal  of the  product container when
            empty.

            Definition of Terms;
            gal - gallon
            tsp - teaspoon
            oz - ounce
            mg - milligram
            fl.oz - fluid ounce
            a.i. -  active  ingredient
             Issued:   12-03-84              V. 1-068501-1

-------
            Site, Efficacy,
            Dosage and  Formulaeion

            AQUATIC  NON-FOOD

            (Aquatic Sites)

/65018MA    Air  Washer  Water
             Systems
           (15)

EPA Index to Pesticide Chemicals

                     Use Directions
                                    General  Instructions  for Use:  The products regis-
                                    tered  for  this  site are intended to control the
                                    growth of  slime-forming bacteria, fungi and algae.

                                    Badly  fouled  systems  must be cleaned by any suit-
                                    able means before  treatment is begun.  Make appli-
                                    cation at  a point  in  the system where  the chemical
                                    will be  uniformly  mixed.

                                    Purple color  of water indicates chemical activity
                                    and should last at least 20 minutes.   Add more
                                    chemical if color  disappears within 20 to 30 min-
                                    utes after first treatment.
A28           Microbicide/microbistat
DBABAAA       Slime-forming bacteria
FYAFQBB       Slime-forming fungi
PKAAAAA       Algae
                54 ppm (3.6 oz of
                 a.i.  per 500 gal
                 of water)
                (80% P/T)
                27 ppm (3.6 oz of
                 a.i.  per 1,000
                 gal of water
                (80% P/T)
  Initial treatment.
  Water treatment.  Shock treatment.  Close bleed-off
  valve and drop briquette into pan near intake.  Af-
  ter treatment drain sump and remove dead algae from
  slats and sump.  Flush and refill with clean water.

  Subsequent treatment.
  Water treatment.  Maintenance application.  Close
  bleed-off valve and drop briquette into pan near
  intake.  After treatment drain sump and remove dead
  algae from slats and sump.  Flush and refill with
  clean water.
            Issued:   12-03-84
         V. 1-068501-2

-------
/65023MA
Site, Efficacy,
Dosage and  Formulation

Aquaria Water  Ponds
 (Ornamental Fish
 Ponds)
                                               (16)

                                   EPA Index Co Pesticide Chemicals

                                                        Use Directions
PKAAAAA
  Algae

    1 tsp of product
     per 1 fl.oz of
     water
    (41Z SC/S)

    4 ppm (1 tsp of
     product per 4 gal
     of water)
    (1.2% RTU)
/65019MA
Commercial and  Indus-
 trial Water Cooling
 Towers and Evapora-
 tive Condensers
                                     General Instructions for Use:   The products  regis-
                                     tered for this site are intended to be used  as  al-
                                     gaecides.

                                     Add product as directed by label.
                                     Water treatment.  Algae control.   For  goldfish,  add
                                     4 to 5 drops per gallon.  For  tropical fish,  add
                                     up to 2 drops per gallon.   For bait minnows,  add 3
                                     drops per gallon.
                                     Water treatment.
                                     weeks.
Algae control.   Apply every 2
                                     General Instructions for Use:  The  products  regis-
                                     tered for this site are intended  to control  the
                                     growth of slime-forming bacteria, fungi  and  algae
                                     which impair the efficiency  of  the  system.   Methods
                                     of application may be slug  feed treatment, inter-
                                     mittent feed treatment, or continuous  feed treat-
                                     ment.

                                     Slug feed treatment.  Treatment that involves  addi-
                                     tion of a specified dose to  the system at  1  time.
                                     Treatment may be repeated at intervals,  usually
                                     once a day or less frequently.

                                     Intermittent feed treatment.  Treatment  that is on
                                     a semi-continuous basis. Provides  a continuous
                                     dosage over a brief period and  is repeated at
                                     stated intervals.

                                     Continuous feed treatment.   Treatment  that is  on
                                     an uninterrupted basis to provide a sustained  con-
                                     centration.   Usually an initial slug dose  is used
                                     to establish control prior  to continuous treatment.

                                     When algal or microbial growth  is noticed, an  ini-
                                     tial high concentration dosage  is used and repeated
                                     until control is achieved.   When control is  evi-
                                     dent, a subsequent dosage of lower  concentration
             Issued:   12-03-84
                               V.1-068501-3

-------
            Site,  Efficacy.
            Dosage and Formulation
            (17)
EPA Index Co Pescicide Chemicals

  	          Use Directions
            Commercial  and Industrial Water  Cooling  Towers  and  Evaporative Condensers
             (continued)   "~~~~

                                    is used  Co  maintain  control.   Should  algae  or  slime
                                    become visible again,  the  initial  slug dose should
                                    be used,  followed  by Che maintenance  procedure.

                                    Purple color  of  water  indicates chemical  activity
                                    and  should  last  at least 20 minutes.  Add more
                                    chemical if color  disappears within 20 to 30 min-
                                    utes after  first treatment.

A28           Microbicide/microbistat
DBABAAA       Slime-forming bacteria
FYAFQBB       Slime-forming fungi
PKAAAAA       Algae
                54 ppm (3.6  oz  of
                 a.i.  per  500 gal
                 of water)
                (80% P/T)

                62 ppm (2.5  gal of
                 product per 1,000
                 gal of water)
                (2.5% RTU)
                27  ppm (3.6  oz of
                 a.i.  per 1,000
                 gal of water)
                (80% P/T)
  Initial treatment.
  Water treatment.  Shock treatment.  Close bleed-off
  valve and drop briquette into pan near intake.  Af-
  ter treatment drain sump and remove dead algae from
  slats and sump.  Flush and refill with clean water.

  Water treatment.  Shock treatment.  Close bleed-off
  valve and apply product directly into cooling ba-
  sin.  Watch for clogging in the circulation.  When
  algae is loosened and Che purple color disappears,
  drain sump, remove debris and dead algae from slats
  and sump.  Flush and refill wich clean water.

  Subsequent treatment.
  Water treatment.  Maintenance application.  Close
  bleed-off valve and drop briquette into pan near
  intake.  After treatment drain sump and remove dead
  algae from slats and sump.  Flush and refill with
  clean water.
                31  ppm (1.25  gal  of  Water  treatment.   Maintenance application.   Initi-
                 product  per  1,000   ate  after  shock  treatment  and repeat every  2 weeks
                 gal  of water)       or less  if algae  reappears.
                (2.5% RTU)
            Issued:   12-03-84
         V.1-068501-4

-------
            Sice,  Efficacy.
            Dosage and Formulation

/65015MA    Human Drinking Water
                                  (18)
                      EPA Index to Pesticide Chemicals

                                           Use Directions
                                    General Instructions for Use:   The  products in this
                                    section are registered as algaecides for treatment
                                    of municipal human drinking water  systems (i.e.,
                                    water supplies and components  of the system).
PKAAAAA
  Algae
                4.4-4.5 ppm (1.1    Algae control.  Product should be applied as early
                 mg of product per  as possible in the treatment  process.   Application
                 gal of water)      to the raw water intake should be applied contin-
                OS. 642, 98% Cr)    uously.
/65009MA
/65009HC
Poultry Drinking Water
A23
  Sanitizer

    272-543 ppm (0.648
     to 1.296 grains
     of product per
     quart of water)
    (40% P/T)
                        General Instructions for Use;   The product in this
                        section is registered for sanitization of poultry
                        drinking water.   Regular treatment of water helps
                        reduce  contamination by pathogenic microorganisms
                        and  slime-forming microorganisms.

                        Apply product only as specified on the label and
                        technical data sheet.
                                    Sanitization of poultry  water.
            Issued:   12-03-84
                               V.1-06850L-5

-------
            Site, Efficacy.
            Dosage and Formulation

            INDOOR
            (Pets and Domestic Animals)
            (Animals and Their Man-Made Premises)
                                  (19)

                      EPA Index to Pesticide Chemicals

                                           Use Directions
/540301A
Fish (Pets)
IIEAABA
IIAAABA
  Anchorworms
  Fishlice

    1 tsp of product
     per 1 fl.oz of
     water (2-5 drops
     per gal aquarium
     of pond water)
    (41% SC/S)
                                     General  Instructions  for Use;  The product regis-
                                     tered  in this  site  is  intended to control crusta-
                                     ceans.

                                     Add product  as directed by  label.
                                     Animal  treatment.   For goldfish, add 4 to 5 drops
                                     per gallon.   For  tropical  fish, add up to 2 drops
                                     per gallon.   For  bait minnows, add 3 drops per
                                     gallon.
            Issued:  12-03-84
                               V.1-068501-6

-------
                                              (20)

                                  EPA  Index Co Pesticide Chemicals

             Listing of  Registered Pesticide Products by Formulation

&040.0005    40%  pelleted/tableted
              potassium permanganate (068S01)                             40.0%
                 005887-00001

&080.0005    80%  pelleted/tableted
              potassium permanganate (068501)                             80.0%
                 009640-00037

&095.6408    95.64% crystalline
              potassium permanganate (068501)                             95.64%
                 008429-00007

&098.0008    98%  crystalline
              potassium permanganate (068501)                             98.0%
                 008429-00006

&041.0015   41%  soluble  concentrate/solid
              potassium  permanganate (068501)                             41.0%
                008057-00001

&201.2016    1.2% liquid-ready to use
              potassium permanganate (068501)                              1.2%
                008220-00001

&202.5016    2.5% liquid-ready to use
              potassium permanganate (068501)                              2.5%
                001769-00191   010827-00062
9999999     State Label Registrations

              AZ Reg. No.
                037804-08405

              CA Reg. No.
                011012-06314

              FL Reg. No.
                036218-06323

              MD Reg. No.
                037916-09534
            Issued:  12-03-84
                                           V.1-068501-7

-------
/650L8MA
/65023MA
/650L9MA
/65015MA
/65009MA
/65009HC
                                 (21)

                      EPA Index Co Pescicide Chemicals

                                 Appendix B

Listing of Registration Numbers by Site and Formulations

AQUATIC SON-FOOD

(Aquatic Sites)

Air Washer Water Systems
  (80% P/T)
    009640-00037

Aquaria Water Ponds (Ornamental Fish Ponds)
  (412 SC/S)
    008057-00001

  (1.2% RTU)
    008220-00001

Commercial and Industrial Water Cooling Towers and Evaporative Condensers
  (80% P/T)
    009640-00037

  (2.5% RTU)
    001769-00191   010827-00062

Human Drinking Water
  (95.642 Cr)
    008429-00007

  (98% Cr)
    008429-00006

Poultry Drinking Water

  (40% P/T)
    005887-00001

INDOOR

(Pets and Domestic Animals)
(Animals and Their Man-Made Premises)
/54030IA    Fish (Pets)
              (41% SC/S)
                008057-00001
            Issued:  12-03-84
                               V.1-068501-8

-------
 Keg. No.

 402-65

 875-41

 875-62

 1269-47

 1270-70

 5362-9

 5736-37

 9594-5

 10183-6
        EPA Index co Pesticide Chemicals

            Auxiliary  Documentation

% Potassium Permanganate           Comments
         0.01Z

         0.01Z

         0.004Z

         0.01Z

         0.01Z

         0.01Z

         0.015Z

         0.01Z

         0.01Z
percent too low to
 be effective
percent too low to
 be effective
percent too low to
 be effective
percent too low to
 be effective
percent too low to
 be effective
percent too low to
 be effective
percent too low to
 be effective
percent too low to
 be effective
percent too low to
 be effective
Labe1 Improvement.
The words "organic matter"  (occurring on  label numbers 1769-191, 9640-37
and 10827-62) were interpreted  to mean  "slime-forming fungi and slime-
forming bacteria".
Issued:  12-03-84
                 V.l-068501-a

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             (23)
                     TABLE A
GENERIC DATA REQUIREMENTS FOR POTASSIUM PERMANGANATE
Guideline Citation and
Name of Test
§158.120 Product Chemistry
Product Identity:
Test
Substance

61-1 - Product Identity and Disclosure TGAI
of Ingredients
61-2 - Description of Beginning Materials TGAI
and Manufacturing Process
61-3 - Discussion of Formation of TGAI
Impurities
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis
Physical and Chemical Characteristics
63-2 - Color
63-3 - Physical State
63-4 - Odor
63-5 - Melting Point
63-6 - Boiling Point
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
Guidelines
Status
R
R
R
CR
R
R
R
R
R
Are Data
Required
Yes

[xj
n
D
[x]
M
[x]
M
(-j
Footnote
Number
No
n 2
D 2.3
[x]
IxJ 3
I")
[x]
n
[x]
IxJ
Data Must Be
Submitted Within
Time Frames Listed
Below I/
6 months
6 Months
6 Months
6 Months

-------
                                                          (24)
                                                       TABLE A
                                  GENERIC DATA REQUIREMENTS FOR POTASSIUM PERMANGANATE
Guideline Citation and
Name of Test
  Test      Guidelines
Substance     Status
  Are Data
  Required
 Yes      No
          Footnote
           Number
Data must Be
Submitted Within
Time Frames Listed
Below I/
§158.120 Product Chemistry (Continued)

Physical and Chemical Characteristics
(Continued)

  63-7  - Density, Bulk Density, or          TGAI         R
          Specific Gravity

  63-8  - Solubility                      TGAI or PAI     R

  63-9  - Vapor Pressure                      PAI         R

  63-10 - Dissociation constant               PAI         R

  63-11 - Octanol/water partition             PAI         R
           coefficient

  63-12 - pH                                  TGAI        R

  63-13 - Stability                           TGAI        R

  Other Requirements;

  64- 1 - Submittal of samples             TGAI, PAI      CR
fxl


Q

Q

[J

o

[x]

[J



['I
o

[x]

Ixl

[x]

[x]


Q

[x]



(*]
     6 Months
     6 Months
  TGAI = Technical Grade of the Active Ingredient; PAI = Pure Active Ingredient; R = Required; CR = Conditionally Required
  I/ Data must be submitted within 6 months after the date the Guidance Document is issued (i.e., June 30, 1986).
  2/ A discussion of the formation of impurities in the commercially available technical grades of potassium perman-
  ~  ganate is not required.  However, for the technical grade of potassium permanganate (TGAI) used in his product,
     the registrant of an end-use product is required to submit detailed composition data which is available to him
     from his supplier.  This data should include information on the heavy metal impurities, if any, in the TGAI.
     The registrant is required to submit generic data for the indicated physical/chemical characteristics.

-------
                                                   (25)
                                                         TABLE A
                                  GENERIC DATA REQUIREMENTS FOR POTASSIUM PERMANGANATE

158.120 Product Chemistry (Continued)

J}/ Potassium permanganate Is readily available commercially in several grades for various industrial uses.
~~  This data is not required for a technical grade or manufacturing use product not registered for pestlcidal use.

-------
                 (26)

                         TABLE  A
GENERIC DATA REQUIREMENTS FOR POTASSIUM PERMANGANATE
Data Requirement Coi
\J Use 2J
nposition Pattern
Does EPA Have
Data To Satisfy
This Require- Bibliographic
ment? (Yes, No Citation
or Partially)
Must Additional Data
Be Submitted Under
PIFRA § 3(c)(2)(B)?
§158.135 Toxicology
ACUTE TESTING:
81-1
81-2
81-3
81-4
81-5

81-7
- Acute Oral Toxlclty - Rat
- Acute Dermal Toxic! ty
- Rabbit
- Acute Inhalation Toxlclty
- Eye Irritation -
Rabbit
- Dermal Irritation -
Rabbit
- Delayed
Neurotoxlcity
TGAI D
TGAI D
TGAI
TGAI D

TGAI D
TGAI
Yes 00100362
Yes 00100362
N/A
Yes 00100362

Yes 00100362
N/A
No
No
-
No

No
-
SUBCHRONIC TESTING:
82-1
82-2
82-3
82-4
82-5
- 90-Day Feeding
- 21 -Day Dermal
- 90 -Day Dermal
- 90-Day Inhalation
- 90-Day Neurotoxiclty
TGAI
TGAI
TGAI
TGAI
TGAI
N/A3/
N/A3/
N/A3/
N/A3/
N/A3/
-
-
-
-
_

-------
                (27)
                     TABLE A
GENERIC DATA REQUIREMENTS FOR POTASSIUM  PERMANGANATE
i/ Use 21
Data Requirement Composition Pattern
§158.135 Toxicology - Continued
CHRONIC TESTING:
83-1 - Chronic Toxicity TGAI
83-2 - Oncogenicity TGAI
83-3 - Teratogeniclty TGAI
83-4 - Reproduction TGAI
MUTAGENICITY TESTING
84-2 - Gene Mutation (Ames Test) TGAI
84-2 - Structural Chromosomal TGAI
Aberration
84-4 - Other Genotoxic Effects TGAI
SPECIAL TESTING
85-1 - General Metabolism PAI or PAIRA
85-2 - Dermal Penetration Choice
86-1 - Domestic Animal Choice
Does EPA Have Must Additional Data
Data To Satisfy Be Submitted Under
This Require- Bibliographic FIFRA § 3(c)(2)(B)?
ment? (Yes, No Citation
or Partially)
N/A3/
N/A^/
N/A3/
N/A3/
N/A3/
N/A_3_/
N/A3/
N/A3/
N/A3/
N/A3/

-------
                                                        (28)


                                                      TABLE A
                                GENERIC DATA REQUIREMENTS FOR POTASSIUM PERMANGANATE


§158.135 Toxicology - Continued

\J Composition:  TGAI = Technical Grade Active Ingredient; PAI = Pure active Ingredient; PAIRA » Pure active ingredient,
   radiolabelled; Choice = Choice of several test substances determined on a case-by-case basis.
21 The use patterns are coded as follows:  A<*Terrestrial, Food Crop; B=Terrest rial, Non-Food; C=Aqautlc, Food Crop;
   D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
_3/ Human and animal exposure to or contact with potassium permanganate results in reduction of the permanganate Ion
   to the lower (naturally occurring) valence states.  As natural manganese in these lower valence states Is ubiquitous,
   and dietary exposure to manganese residues resulting from use of products with potassium permanganate is not a matter
   of concern, chronic and subchronic toxicity studies are not necessary or appropriate for potassium permanganate based
   upon the manganese residues from products containing potassium permanganate.

-------
                                                        (29)
                                                      TABLE A
                                GENERIC DATA REQUIREMENTS FOR POTASSIUM PERMANGANATE
y Use 2/
Data Requirement Composition Pattern
§158.145 Wildlife and
Aquatic Organisms
AVIAN AND MAMMALIAN TESTING
71-1 - Acute Avian Oral Toxicity TGAI D
71-2 - Avian Subacute Dietary TGAI D^/
Toxicity
71-3 - Wild Mammal Toxicity TGAI
71-4 - Avian Reproduction TGAI
71-5 - Simulated Field Testing TEP
AQUATIC ORGANISM TESTING
Does EPA Have
Data To Satisfy
This Require- Bibliographic
ment? (Yes, No Citation
or Partially)
No
No
N/A
N/A
N/A
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Time Frame for Data
Submission 3/
Yes 9 Months
Yes 9 Month
72-1 - Freshwater Fish Toxicity    TGAI
        - Coldwater Fish Species,
          and

        - Warmwater Fish Species

72-2 - Acute Toxicity to           TGAI
        Freshwater Invertebrates
D

D
No


Yes

No
      GS0220-001
GS0220-002, GS0220-003
Yes


No

Yes
                                                              9 Month
                                       9 Month

-------
                                                          (30)
                                                        TABLE A
                                  GENERIC DATA REQUIREMENTS FOR POTASSIUM PERMANGANATE
                                                              Does EPA Have                           Must Additional Data
                                                              Data To Satisfy                         Be Submitted Under
                                            I/     Use  y    This Require-       Bibliographic       FIFRA § 3(c)(2)(B)?
Data Requirement                 Composition     Pattern      ment?  (Yes, No       Citation          Time Frame for Data
^__	or Partially)	Submission V	

S158.145 Wildlife and
 Aquatic Organisms - Continued

  72-4 - Fish Early Life Stage,      TGAI           -              N/A
          and
          - Aquatic Invertebrate
             Life-Cycle

  72-5 - Fish - Life-Cycle           TGAI                          N/A                  -

  72-6 - Aquatic Organism        TGAI, PAI OR                      N/A                  -
          Accumulation            Degradation
                                    Product

  72-7 - Simulated Field Testing/    TEP                           N/A                  -
         Actual Field Testing

  [[[

  I/ Composition:  TGAI = Technical grade of the active ingredient; PAI = pure active  ingredient;
     TEP = Typical end-use product;
  y The use patterns are ceded as follows:  A=Terrestrial, Food Crop; B=Terrestrial,  Non-Food Crop;  C= Aquatic, Food Crop;
  ~  n=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.

-------
                                                     (31)
                                                       TABLE A
                                  GENERIC DATA REQUIREMENTS FOR POTASSIUM PERMANGANATE
                                            I/
Data Requirement
                               Composition
  Use  2/
Pattern
Does EPA Have
Data To Satisfy
This Require-
ment?  (Yes, No
or Partially)
Bibliographic
  Citation
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Time Frame for Data
Submission •*/
§158.130 Environmental Fate

  DEGRADATION STUDIES-LAB;

  161-1 - Hydrolysis

  Photodegradatlon

  161-2 - In water

  161-3 - On soil

  161-4 - In Air

  METABOLISM STUDIES-LAB;

  162-1 - Aerobic Soil

  162-2 - Anaerobic Soil
                               TGAI or PAIRA      C,D



                               TGAI or PAIRA      C.D

                               TGAI or PAIRA      _

                               TGAI or PAIRA      _



                               TGAI or PAIRA

                               TGAI or PAIRA
  162-3 - Anaerobic Aquatic      TGAI or PAIRA      C,D

  162-4 - Aerobic Aquatic        TGAI or PAIRA      C,D

  MOBILITY STUDIES:

                                 TGAI or PAIRA      C,D
163-1  - Leaching and
        Adsorption/Desorption

163-2  - Volatility  (Lab)

163-3  - Volatility  (Field)
                                     TEP

                                     TEP
                   No
                   No
                   No

                   No



                   No
                                           Yes
                                           Yes
                                9 Months
                                9 Months
                                           Yes     27 Months

                                           Yes     27 Months



                                           Yes*/   12 Month

-------
                    (32)
                      TABLE A
GENERIC DATA REQUIREMENTS FOR  POTASSIUM  PERMANGANATE
Data Requirement
\_l Use 2J
Composition Pattern
Does EPA Have Must Additional Data
Data To Satisfy Be Submitted Under
This Require- Bibliographic FIFRA § 3(c)(2)(B)?
ment? (Yes, No Citation Time Frame for Data
or Partially) Submission 3/
§158.130 Environmental Fate - Continued
DISSIPATION STUDIES-FIELD:
164-1 -
164-2 -
164-3 -
164-4 -

164-5 -
Soil
Aquatic (Sediment)
Forestry
Combination and
Tank Mixes
Soil, Long-term
TEP
TEP C.D
TEP
- -

TEP
N/A
No - Yes 27 Months
N/A
N/A

N/A
ACCUMULATION STUDIES:
165-1 -
165-2 -
165-3 -
165-4 -
165-5 -
SUBPART




Rotational Crops
(Confined)
Rotational Crops
(Field)
Irrigated Crops
In Fish
In Aquatic Non-Target
Organisms
K - REENTRY:
Foliar Dissipation
Soil Dissipation
Dermal Exposure
inhalation Kxpo&urc
PAIRA
TEP
TEP
TGAI or PAIRA C,D
TEP C,D
TEP C,D
TEP C.D
TEP C,D
THP C,D
N/A
N/A
N/A
No - No£/
No - No5./
N/A
N/A
N/A
N/A

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                                                      TABLE A
                              GENERIC DATA REQUIREMENTS FOR POTASSIUM PERMANGANATE

 §158.130 Environmental Fate - Continued

J/ Composition:  TGAI = Technical grade of the active ingredient; PAIRA = Pure active ingredient, radiolabelled;
   TEP = Typical end-use product.
2/ The use patterns are coded as follows:  A=Terrestrial, Food Crop; B=Terrestrial, Non-Food; C=Aquatic, Food Crop;
   D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Doroestic Outdoor; I=Indoor.
V Data must be submitted within the indicated time frame, based on the date of the Guidance Document.
    0  9 Month Due Date is September 30, 1986.
    0 12 Month Due Date is December 31, 1986.
    0 27 Month Due Date is March 31, 1988.
£/ Adsorption/desorption test required.
5/ Waived because it is assumed that the chemical has a low potential for bioaccumulation in aquatic species
   because of its appreciable water solubility and probably has a very low octanol/water partition coefficient.

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                                 (33)

                                        TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS  FOR  END-USE PRODUCTS  CONTAINING  POTASSIUM  PERMANGANATE
Guideline Citation and
Name of Test
§158.120 Product Chemistry
Product Identity:
Test
Substance^/

61-1 - Product Identity and Disclosure EP
of Ingredients
61-2 - Description of Beginning Materials EP
and Manufacturing Process
61-3 - Discussion of Formation of EP
Impurities
Analysis and Certification of Product
Ingredients
62-1 - Preliminary Analysis
62-2 - Certification of Limits
62-3 - Analytical Methods to Verify
Certified Limit
Physical and Chemical Characteristics
63-2 - Color
63-3 - Physical State
63-4 - Odor
EP
EP
EP
EP
EP
EP
Guidelines
Status
R
R
R
CR
R
R
R
R
R
Are Data Footnote
Required Number
Yes No
M
Ixl
[x]
n
[xj
n
[x]
IJ
[x]
[x]
n 3
n 3
(xl
n
[x]
n
[x]
n
Data Must Be
Submitted Within
Time Frames List
Below2/
6 Months
6 Months
12 Months
6 Months
6 Months

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                                                     (34)
                                                      TABLE  B
             PRODUCT SPECIFIC DATA REQUIREMENTS  FOR END-USE  PRODUCTS CONTAINING POTASSIUM PERMANGANATE
Guideline Citation and
Name of Test
§158.120 Product Chemistry (Continued)
Physical and Chemical Characteristics
(Continued)
63-7 - Density, Bulk Density, or
Specific Gravity
63-12 - pH
63-14 - Oxidizing or Reducing
Action
63-15 - Flammability
63-16 - Explodability
63-17 - Storage Stability
63-18 - Viscosity
63-19 - Mlscibility
63-20 - Corrosion Characteristics
Other Requirements:
64- 1 - Submit tal of samples

Test
Substance _|/


EP
EP
EP
EP
EP
EP
EP
EP
EP

EP

Guidelines
Status


R
CR
CR
CR
R
R
CR
CR
R

CR

Are Data
Required
Yes 1


[xj
IxJ
n
n
n
fxl
n
n
Ix)

n

Footnote
Number
No


l~l
n
Ix) •
IxJ
IxJ
n
[xj
IxJ
n

IxJ

Data Must Be
Submitted Within
Time Frames List
Below2


6 Months
6 Months



15 Months


15 Months



   Test  Substance:  EP = End-use Product.   Guidelines Status R = Required;  CR = Conditionally Required
\J Because there are no registered manufacturing use products for potassium permanganate,  the Product Specific data re-
   quirements are applied to the end-use  products.

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                                                      TABLE R
             PRODUCE SPECIFIC DATA REQUIREMENTS FOR END-USE PRODUCTS CONTAINING POTASSIUM PERMANGANATE


§158.120 Product Chemistry (Continued)

2/ Data must be submitted within the indicated time frame, based on the date of the Guidance Document.
    0  6 Month Due Date is June 30, 1986.
    0 12 Month Due Date is December 31, 1986.
    0 15 Month Due Date is March 31, 1986.
V For the end-use product, information is required concerning the quality control procedures and a discussion of impuri-
   ties that may form in the product during its commercial life.

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                                                        TABLE B
               PRODUCT SPECIFIC DATA REQUIREMENTS FOR END-USE PRODUCTS CONTAINING POTASSIUM PERMANGANATE
Data Requirement
Composition"
                                                I/
Does EPA Have
Data To Satisfy
This Require-
ment?  (Yes, No
or Partially)
Bibliographic
  Citation
Must Additional Data
Be Submitted Under
FIFRA § 3(C)(2)(B)?
Time Frame for Data
Submission 2/
S158.135 Toxicology

  ACUTE TESTING
  81-1 - Acute Oral Toxicity - Rat       EP

  81-2 - Acute Dermal Toxicity           EP
          - Rabbit

  81-3 - Acute Inhalation Toxicity       EP
          - Rat

  81-4 - Primary Eye                     EP
          Irritation - Rabbit

  81-5 - Primary Dermal                  EP
          Irritation - Rabbit

  81-6 - Dermal Sensitization -          EP
         Guinea Pig
                             No

                             No


                             N/A


                             No


                             No


                             N/A
                                             YesV

                                             Yes3/
                                             YesV


                                             Yes3/
                                  9 Month

                                  9 Month
                                  9 Month
                                  9 Month
  \J Composition:  EP = End-use product.  Because there are no registered manufacturing use products for potassium
     permanganate, the Product Specific data requirements are applied to the end-use products.
  2/ Data must be submitted within 9 months after the date the Guidance Document was issued (i.e., September 30, 1986).
  3/ Toxicity data is required to enable the Agency to establish the acute toxicity categories for each end-use product,
     and thus prescribe appropriate predautionary statements in accordance with Section 162.10 of 40 CPR.
                                                                                                                          ut
                                                                                                                          a\

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                                                        (37)
          REQUIREMENT FOR SUBMISSION OF GENERIC DATA

     A.  This portion of the guidance document is a Notice
issued under the authority of FIFRA sec. 3(c)(2)(B).  The
tables following this section list the data required for
maintaining the registrability of each product.

     EPA has determined that additional generic data described
in Table A must be submitted to EPA for evaluation in order
to maintain in effect the registration(s)  of your product(s)
identified as an attachment to the cover letter accompanying
this guidance document.  'As required by FZFRA sec. 3(c)(2)(B),
you are required to take appropriate steps to comply with
this Notice.

     EPA may suspend the registration of each of those products
unless, within the specified time, you have informed EPA how
you will satisfy the requirements of this Notice.  Any such
suspension will remain in effect until you have complied with
the terms of this Notice.

   B.  What Generic Data1/ Must be Submitted.  You may deter-
mine which generic data you must submit by consulting Table A
at the end of this chapter.  That table lists the generic
data needed to evaluate the continued registrability of all
products, and the dates by which the data must be submitted.
The required studies must be conducted in accordance with
EPA approved protocols (such as those contained in the Pesticide
Assessment Guidelines ^/ or data collected under the approved
protocols of the Organization for Economic Cooperation and
Development (OECD).  If you do not wish to develop data
in support of certain uses appearing in your labeling, you
may delete those uses at the time you submit your revised
labeling.

     For certain kinds of testing (generally ecological
effects), EPA requires the test substance to be a "typical
formulation," and in those cases EPA needs data of that type
   V Generic data pertain to the properties or effects of a
particular ingredient, and thus are relevant to an evaluation of
the risks of all products containing that ingredient, regardless
of the product's unique composition or specific use.  Product-
specific data relate only to the properties or effects of a
product with a particular composition (or a group of products
with closely similar composition).
                         •
   £/ The Pesticide Assessment Guidelines are available in hard
copy or microfiche from the National Technical Information
Service, 5285 Port Royal Road, Springfield, Va.  22161.

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                                                        (38)
for each major formulation category (e.g., emulsiflable concen-
trates, wettable powders, granulars, etc.)  These are classified
as generic data and when needed are specified in Table A.
EPA may possess data on certain "typical formulations" but
not others.  Note;  "Typical formulation" data should not  be
confused with product-specific data (Table B) which are
required on each formulation.  Product-specific data are
further explained in Chapter III of this document.

   C.  Options Available for Complying With Requirements
       to Submit Data

     Within 90 days of your receipt of this Notice you must
submit to EPA a completed copy of the form entitled "FIFRA
Section 3(c)(2)(B) Summary Sheet" [EPA Form 8580-1, Appendix
II-3] for each of your products.  On that form you must state
which of the following methods you will use to comply with
the requirements of this Notice:

    1.  (a) Notify EPA that you will submit the data, and

        (b) either submit the existing data you believe will
    satisfy the requirement, or state that you will generate
    the data by conducting testing.  If the test procedures
    you will use deviate from (or are not specified in) the
    Pesticide Assessment Guidelines or protocols contained in
    the Reports of Expert Groups to the Chemicals Group,
    Organization for Economic Cooperation and Development
    (OECD) Chemicals Testing Programme, you must enclose the
    protocols you will use.

                              OR

    2.  Notify EPA that you have entered into an agreement
    with one or more other registrants to jointly develop  (or
    share in the cost of developing) the data.  If you elect
    this option, you must notify EPA which registrant(s) are
    parties to the agreement.

                              OR

    3.  File with EPA a completed "Certification of Attempt to
    Enter Into an Agreement With Other Registrants for Develop-
    ment of Data" (EPA Form 8580-6, Appendix II-4)V
     *_/ FIFRA sec.  3(c)(2)(B) authorizes joint development of
data by two or more registrants, and provides a mechanism by
which parties can obtain an arbitrator's decision if they agree
to jointly develop  data but fail to agree on all the terms of
the agreement.  The statute does not compel any registrant to
agree to develop data jointly.
               (Footnote continued on next page)

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                                                              (39)
                              OR

    4.  Request that EPA amend your registration by deleting
    the uses for which the data are needed.  (This option is
    not available to applicants for new products.)
                              OR
    5.  Request voluntary cancellation of the registration(s)
    of your products for which the data are needed.  (This option
    is not available to applicants for new products.)

    D.  Procedures for Requesting Changes in Testing Methodology
        and Extensions of Time

     EPA recognizes that you may disagree with our conclusions
regarding the appropriate ways to develop the required data
or how quickly the data must be submitted.  If the test
procedures you plan to use deviate from (or are not specified
in) the registration guidelines or protocols contained in
the reports of the Expert Groups to the Chemical Groups,
Organization for Economic Cooperation and Development (OECD)
Chemicals Testing Programme, you must submit the protocol
for Agency review prior to the initiation of the test.

     If you think that you will need more time to generate the
required data than is allowed by EPA's schedule, you may submit a
request for an extension of time.  Any request for a time extension
which is made as an initial response to a section 3(c)(2)(B) notice
must be submitted in writing to the Product Manager.  However, once
dates have been committed to and EPA has accepted those commitments,
any subsequent requests for a time extension must be submitted in
writing to the Office of Compliance Monitoring.
(Footnote continued from previous page)
       In EPA's opinion, joint data development by all regis-
trants subject to a data requirement or a cost-sharing agreement
among all such registrants is clearly in the public interest.
Duplication of testing could increase costs, tie up testing
facilities, and subject an unnecessarily large number of
animals to testing.

      As noted earlier, EPA has discretion to suspend the
registration of a product when a registrant fails to submit data
required under FIFRA Section 3(c)(2)(B).  EPA has concluded that
it should encourage joint testing rather than duplicative
testing, and that suspension should be withheld in certain cases.
to further this goal.  Accordingly, if (1) a registrant has
informed us of his intent to develop and submit data required
by this Notice; and (2) a second registrant informs EPA that
it has made a bona fide offer to the first registrant to share
in the expenses of the testing [on terms to be agreed upon
or determined by arbitration under FIFRA Section 3(c)(2)(B)(iii)];
and (3) the first registrant has declined to agree to enter
into a cost-sharing agreement, EPA will not suspend the
second firm's registration.

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                                                            C40)
The extension request should state the reasons why you believe
that an extension  is appropriate.  While EPA considers your
request, you must  strive to meet the deadline for submitting
the required data.


III.  REQUIREMENT  FOR SUBMISSION OF PRODUCT-SPECIFIC DATA

     Note:  Unless  stated otherwise in Section I, Regulatory
Position and Rationale, this Section applies only to manufac-
turing use products, not to end use products.

     A necessary first step in determining which statements
must appear on your product's label is the .completion and
submission to EPA  of product-specific data* listed on the
form entitled "Product Specific Data Report"  (EPA Form
8580-4, Appendix III-l) to fill gaps identified by EPA
concerning your product.  Under the authority of FIFRA sec.
3(c)(2)(B), EPA has determined that you must submit these
data to EPA in order to reregister your product(s).  All of
these data must be  submitted not later than six months after
you receive this guidance document.

     Table B—Product-Specific Data Requirements for Manufacturing
Use Products—lists the product specific data you must submit.
Data that are required to be submitted are identified in the
column of those tables entitled "Must Data By Submitted
Under §3(c)(2)(B).
n
IV.  SUBMISSION  OF  REVISED LABELING

Note;  This  section applies to  end use products only to the
extent described in Section I  (Regulatory Position and
Rationale).   Otnerwise,  the following information pertains
exclusively  to manufacturing use  products.

     FIFRA  requires each product  to  be labeled with accurate,
complete and sufficient  instructions and precautions, reflecting
the  results  of data concerning  the product and its ingredients.
Labeling requirements  are set out in 40 CFR  162.10 (see
Appendix IV-1) and  are summarized for products containing
this active  ingredient as part  of this Guidance Document
(See Appendix IV-2).  Applications submitted in response to
this notice  must include draft  labeling for  Agency review.
*_/  Product  specific data pertain to data  that  support the
formulation which is marketed;  it usually includes product
chemistry data and acute toxicity data.

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                                                            (41)
     If you fail to submit revised labeling information
complying with this section (supplemented by requirements
described in Section I,  Regulatory Position and Rationale),
EPA may issue a notice of intent to cancel the registration
under FIFRA sec. 6(b)(l).

                      A.  Label Contents

     40 CFR 162.10 requires that certain specific labeling
statements appear at certain locations on the label.   This
is referred to as format labeling.  Specific label items
listed below are keyed to Appendix IV-2.

     Item 1.  PRODUCT NAME - The name, brand or trademark is
required to be located on the front panel, preferably centered
in the upper part of the panel.  The name of a product will
not be accepted if it is false or misleading.

     Item 2.  COMPANY NAME AND ADDRESS - The name and address
of the registrant or distributor is required on the label.
The name and address should preferably be located at  the
bottom of the front panel or at the end of the label  text.

     Item 3.  NET CONTENTS - A net contents statement is
required on all labels or on the container of the pesticide.
The preferred location is the bottom of the front panel
immediately above the company name and address, or at the end
of the label text.  The net contents must be expressed in the
largest suitable unit, e.g., "1 pound 10 ounces" rather than
"26 ounces." In addition to English units, net contents may
be expressed in metric units.  See Appendix IV-1.  [40 CFR
162.10(d)]

     Item 4.  EPA REGISTRATION NUMBER - The registration
number assigned to the pesticide product must appear on the
label, preceded by the phrase "EPA Registration No.," or "EPA
Reg. No."  The registration number must be set in type of a
size and style similar to other print on that part of the
label on wnich it appears and must run parallel to it.  The
registration number and the required  identifying phrase must
not appear  in such a manner as to suggest oc  imply recommendation
or endorsement of the product by the Agency.  See Appendix IV-1.
[40 CFR 162.10(e)]

    Item  5.  EPA  ESTABLISHMENT NUMBER - The  EPA establishment
number, preceded  by the phrase "EPA Est."  is  the final estab-
lishment at which the product was produced, and may appear
in any suitable location on the label or  immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment  number on the immediate
container cannot  be clearly read  through  such wrapper or container
See Appendix IV-1.   [40 CFR 162.10(f)]

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                                                               (42)
    Item 6A. INGREDIENTS STATEMENT - An ingredients statement
is required on  the  front panel.  The ingredients statement must
contain the name and percentage by weight of each active ingredient
and the total percentage by weight of all inert ingredients.
The preferred location  is  immediately below the product name.
The ingredients statement  must run parallel with, and be clearly
distinguished from, other  text on the panel.  It must not be
placed in the body  of other text.  See Appendix IV-1.   [40 CFR
162.10(g)]

    Item 6B.  POUNDS PER GALLON STATEMENT - For liquid agricul-
tural formulations, the pounds per gallon of active ingredient
must be indicated on the label.

    Item 7.  FRONT  LABEL PRECAUTIONARY STATEMENTS - Front panel
precautionary statements must be grouped together, preferably
within a block  outline.  The table below shows the minimum type
size requirements for various size labels.

    Size of Label        Signal Word          "Keep Out of Reach
    on Front Panel       Minimum Type Size       of Children"
    in Square Inches     All Capitals          Minimum Type Size

    5 and under                6 point              6 point
    above 5 to  10             10 point              6 point
    above 10 to 15            12 point              8 point
    above 15 to 30            14 point             10 point
    over 30                   18 point             12 point

    Item 7A.  CHILD HAZARD WARNING STATEMENT - The Statement
"Keep Out of Reach  of Children" must be located on the front
panel above the signal  word except where contact with children
during distribution or  use is unlikely.  See Appendix IV-1.
[40 CFR 162.10(h)(l)(ii)]

    Item 7B.  SIGNAL WORD  - The signal word (DANGER, WARNING,
or CAUTION) is  required on the front panel immediately below
the child hazard warning statement.  See Appendix IV-1.
[40 CFR 162.10  (h)(1)(i)]

    Item 7C.  SKULL & CROSSBONES AND WORD "POISON" - On products
assigned a toxicity Category I on the basis of oral, dermal,
or inhalation toxicity, the word "Poison" shall appear on the
label in red on a background of distinctly contrasting color and
the skull and crossbones shall appear in immediate proximity to
the word POISON.  See Appendix IV-1.   [40 CFR 162.10(h)(1)(i)]

    Item 7D.  STATEMENT OF PRACTICAL TREATMENT - A statement
of practical treatment  (first aid or other) shall appear on
the label of pesticide  products in toxicity Categories I,
II, and III.  See Appendix IV-1.   [40 CFR 162.10(h)(1)(iii)]

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    Item 7E.  REFERRAL STATEMENT - The statement "See Side
(or Back) Panel for Additional Precautionary Statements" is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
See Appendix IV-1.  [40 CFR 162. 10( h) ( 1) ( ii i ) ]

    Item 8.  SIDE/BACK PANEL PRECAUTIONARY LABELING - The
precautionary statements listed below must appear together
on the label under the heading "PRECAUTIONARY STATEMENTS."
The preferred location is at the top of the side or back
panel preceding the directions for use, and it is preferred
that these statements be surrounded by a block outline.  Each
of the three hazard warning statements must be headed by the
appropriate hazard title.  See Appendix IV-1.  [40 CFR 162.10
(h)(2)].

    Item 8A.  HAZARD TO HUMANS AND DOMESTIC ANIMALS - Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route(s) of exposure and the precautions to be taken to avoid
accident, injury or damage.  See Appendix IV-1.   [40 CFR 162.10
(h)(2)(i)]

    Item 8B.  ENVIRONMENTAL HAZARD - Where a hazard exists  to
non-target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, injury, or damage.  See Appendix IV-1.   [40  CFR
    Item 8C.  PHYSICAL OR CHEMICAL HAZARD

    1.  Flammability statement.  Precautionary statements relating
    to flammability of a product are required to appear on the
    label if  it meets the criteria in Appendix IV-3.  The require-
    ment is based on the results of the flashpoint determinations
    and flame extension tests required to be submitted for all
    products.  These statements are to be located in the -side/back
    panel precautionary statements section, preceded by the
    heading "Physical/Chemical Hazards."  Note that no signal
    word is used in conjunction with the flammability statements.

    2.  Criteria for declaration of non-f lammability .  The
    following criteria will be used to determine if a product
    is non-flammable:

        a.  A "non-flammable gas"  is a gas  (or mixture of gases)
        that  will not ignite when  a lighted match is placed
        against  the open cylinder  valve.

        b.  A "non-flammable liquid" is one having a flashpoint
        greater  than  350°F  (177°C).

-------
        c.  A "non-flammable aerosol" is one which meets the
        following criteria:

            i.  The flame extension is zero inches;

            ii.  There is no flashback; and

            iii.  The flashpoint of the non-volatile liquid
            component is greater than 350°F (177°C).

        3.  Declaration of non-flammability.  Products which
        meet the criteria for non-flanunability specified
        above may bear the notation "non-flammable" or "non-
        flammable (gas, liquid, etc.)" on the label.  It may
        appear as a substatement to the ingredients statement,
        or on a back or side panel, but shall not be highlighted
        or emphasized (as with an  inordinately large type
        size) in any way that may detract from precaution.

        4.  Other physical/chemical hazard statements.  When
        chemistry data demonstrate hazards of a physical or
        chemical nature other than flammability, appropriate
        statements of hazard will be prescribed.  Such statements
        may address hazards of explosivity, oxidizing or reducing
        capability, or mixing with other substances to produce
        toxic fumes.

    Item 9A.  RESTRICTED USE CLASSIFICATION - FIFRA sec. 3(d)
requires that all pesticide formulations/uses be classified
for either general or restricted use.  Products classified
for restricted use may be limited  to use by certified applicators
or persons under their direct supervision (or may be subject
to other restrictions that may be  imposed by regulation).

    In the Registration Standard, the Agency has (1) indicated
certain formulations/uses are to be restricted (Section I
indicates why the product has been classified for restricted
use); or (2) reserved any classification decision until
appropriate data are submitted.

    The Regulatory Position and Rationale states whether
products containing this active ingredient are classified
for restricted use.  If they are restricted the draft label(s)
submitted to the Agency as part of your application must
reflect this determination (see below).

     If you do not believe that your product should be classified
for restricted use, you must submit any information and
rationale with your application for reregistration.  During
the Agency's review of your application, your proposed classi-
fication determination will be evaluated in accordance with
the provisions of 40 CFR 162.ll(c).  You will be notified of
the Agency's classification decision.

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                                                              (45)
     A.  Classification Labeling Requirements

     If Section I of this Guidance Document indicates that
your product has been classified for restricted use,  the
following label requirements apply:

     1.  Front panel statement of restricted use classification.

         a.  The statement "Restricted Use Pesticide" must
         appear at the top of the front panel of the  label.
         The statement must be set in type of the same
         minimum size as required for human hazard signal
         word (see table in 40 CFR 162.10(h){1)(iv)

        .b.  Directly below this statement on the front panel,
         a summary statement of the teems of restriction must
         appear (including the reasons for restriction if
         specified in Section I).  If use is restricted to
         certified applicators, the following statement is
         required:  "For retail sale to and use only  by
         Certified Applicators or persons under their direct
         supervision and only for those uses covered  by the
         Certified Applicator's Certification."

     2.  Some but not all uses restricted.  If the Regulatory
Position and Rationale states that some uses are classified
for restricted use, and some are unclassified, several courses
of action are available:

          a.  You may label the product for Restricted use.
     If you do so, you may include on the label uses  that
     are unrestricted, but you may not distinguish them
     on the label as being unrestricted.

          b.  You may delete all restricted uses from your
     label and submit draft labeling bearing only unrestricted
     uses.

          c.  You may "split" your registration, i.e., register
     two separate products with identical formulations, one
     bearing only unrestricted uses, and the other bearing
     restricted uses.  To do so, submit two applications for
     reregistration, each containing'all forms and necessary
     labels.  Both applications should be submitted simul-
     taneously.  Note that the products will be assigned
     separate registration numbers.

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                                                                (46)
        B.  Compliance Schedules

        No product with a use classified for restricted use
    under this Standard may be released for shipment by the
    registrant or producer after one year from the date of
    issuance of this Standard, unless such product bears the
    restricted use classification.  All products still in
    channels of trade after two years from the date of issuance
    of this Standard must be labeled for restricted use.

    Item 9B  [There is no Item 9B].

    Item 9C.  MISUSE STATEMENT - All products must bear the
misuse statement, "It is a violation of Federal law to use
this product in a manner inconsistent with its labeling."
This statement appears at the beginning of the directions
for use, directly beneath the heading of that section.

    Item 10A.  REENTRY STATEMENT - If a reentry interval
has been established by the Agency, it must be included on
the label.  Additional worker protection statements may be
required in accordance with PR Notice 83-2, March 29, 1983.

    Item 10B   [There is no Item 10B].

    Item IOC.  STORAGE AND DISPOSAL BLOCK -  All labels are
required to bear storage and disposal statements.  These
statements are developed for specific containers, sizes, and
chemical content.  These instructions must be grouped and
appear under the heading "Storage  and Disposal" in the directions
for use.  This heading must be set in the same type sizes as
required for the child hazard warning.  Refer to Appendix
IV-4 to determine the disposal instructions appropriate for
your products.

    Item 10D.  DIRECTIONS FOR USE  - Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide.  When followed, directions must be adequate to
protect the public from  fraud and  from personal injury and to
prevent unreasonable adverse effects on the environment.  See
Appendix IV-1.   [40  CFR  162.10]


    E.  Collateral Labeling

    Bulletins, leaflets, circulars, brochures, data sheets,
flyers, or other written or graphic printed matter which  is
referred  to on the  label or which  is to accompany  the product
are termed collateral  labeling.   Such labeling may not bear
claims  or representations  that differ in  substance from
those accepted in connection  with  registration of  the product.
It  snould be made part  of  the  response  to  this  notice and
submitted for  review.

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                                                                  (47)
V.  INSTRUCTIONS FOR SUBMISSION

A.  For Manufacturing Products (MP) containing Potassium
    Permanganate as an active ingredient.

    1.  Within 90 days from receipt of this document, you must
submit to the Product Manager in the Registration Division at
the address given at the end of this section the "FIFRA Section
3(c)(2)(B) Summary Sheet" EPA Form 8580-1.  Refer to Appendix
II-3 with appropriate attachments.

    If on the Summary Sheet, you commit to develop the data,
request a minor chemical exemption, present arguments that a
data requirement is not applicable, or submit protocols or modified
protocols for Agency review, you must also submit a copy of the
S.ummary Sheet (and any supporting information) to the Office of
Compliance Monitoring, which1 will be monitoring the data generated
in response to this notice.  This information should be submitted
to the Office of Compliance Monitoring at the address given at
the end of this section.  (Actual studies are not to be submitted.)

    2.  Within 6 months from receipt of this document you must
submit to the Product Manager on the Registration Division:

         a.  Confidential Statement of Formula, EPA Form 8570-4.

         b.  Product Specific Data Report, EPA Form 8580-4
    (Appendix III-l).

         c.  Two copies of any required product-specific data.

         d.  Two copies of draft labeling, including the label and
    associated brochures.  If current labeling conforms to the
    requirements of this guidance document and the results of
    the short-term data, you may submit such labeling.  End use
    product labeling must comply specifically with the instructions
    in Section I (Regulatory Position and Rationale) of this
    guidance document.  The labeling should be either typewritten
    text on 8-1/2 x 11 inch paper or a mockup of the labeling
    suitable for storage in 8-1/2 x 11 inch files. The draft
    label must Indicate the intended colors of the final label,
    clear indication of the front panel label, and the intended
    type sizes of the text.

        e.  Evidence of compliance with data support requirements
    of FIFRA sec. 3(c)(l)(D).  Refer to 40 CFR 152.80-152.99
    for latest requirements.

    3.  Within the times set forth in Table A, you must submit
to the Registration Division all generic data, unless you are
eligible for the formulator's exemption.  Any person who cannot
meet the agreed schedule (regarding the submission of test data)
or desires changes in the test protocols must submit a written
request for change to the Office of Compliance Monitoring.

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                                                                (48)
B.  For Manufacturing Use  Products  containing Potassium
    Permanganate in  combination with  other active ingredients

    1.  Within 90 days  from receipt of  this document, you must
submit the "FIFRA Section  3(c)(2)(B)  Summary Sheet," EPA Form
8580-1.  Refer to Appendix II-3 with  appropriate attachments.

    If on the Summary Sheet, you  commit to develop the data,
request a minor chemical exemption, present arguments that a data
requirement is not applicable, or submit protocols or modified
protocols for Agency review, you  must also submit a copy of the
Summary Sheet (and any  supporting information) to the Office of
Compliance Monitoring,  which will be  monitoring the data generated
in response to this  notice.  This information should be submitted
to the Office of Compliance Monitoring  at the address given at
the end of this section.   (Actual studies are not to be submitted.)

    2.  Within the times set forth  in Table A, you must submit
to the Registration  Division all  generic data, unless you are
eligible for the formulator's exemption.  Any person who cannot
meet the agreed schedule (regarding the submission of test data)
or desires changes in the  test protocols must submit a written
request for change to the  Office  of Compliance Monitoring.


C.  For End Use Products containing Potassslum Permanganate
    alone or in combination with  other  active ingredients:

    1.  Within 90 days  from receipt of  this document, you must
submit the "FIFRA Section  3(c)(2)(B)  Summary Sheet," EPA Form
8S80-1.  Refer to Appendix II-3 with  appropriate attachments.

    If on the Summary Sheet, you  commit to develop the data,
request a minor chemical exemption, present arguments that a
data requirement is  not applicable, or  submit protocols or modified
protocols for Agency review, you  must also submit a copy of the
Summary Sheet (and any  supporting Information) to the Office of
Compliance Monitoring,  which will be  monitoring the data generated
in response to this  notice.  This Information should be submitted
to the Office of Compliance Monitoring  at the address given at
the end of this section.   (Actual studies are not to be submitted.)

    2.  Within 6 months from receipt  of this document you must
subtni t :

        a.  Confidential Statement  of Formula, EPA Form 8570-4.

        b.  Product-Specific Data Report, EPA Form 8580-4
    (Appendix III-l).

        c.  Two copies  of  any required  product-specific data.
    (Refer to Table  C).

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                                                              (49)


        d.  Two copies of draft labeling, including Che label and
    associated brochures.  If current labeling conforms to the
    requirements of this guidance document and Che results of
    the short-term data, you may submit such labeling.  End use
    product labeling must comply specifically with the Instructions
    in Section I (Regulatory Position and Rationale) of this
    guidance document.  Labeling should be either typewritten
    text on 8 1/2 x 11 inch paper or a moctcup of the labeling
    suitable for storage in 8 1/2 inch files.  The draft label
    must indicate the Intended colors of the final label, clear
    indication of the front panel label, and the intended type
    sizes of the text.

        e.  Evidence of compliance with data support requirements
    of FIFRA sec. 3(c)(l)(D).  Refer to 40 CFR 152.80-152.99
    (enclosed) for latest requirements.

     3.  Within the time frames set forth in Table A, submit all
generic data, unless you are eligible for the formulator's
exemption.


D.   For intrastate products containing Potassium permanganate
    either as the sole active ingredient or in combination
    with other active ingredients

    These products are being called in for full Federal
registration.  Producers of these products are being sent
a letter Instructing them how to submit an application for
registration.


E.   Applications and other required information should be
submitted to the following address:

    John H. Lee, ?M 31
    Registration Division (TS-767C)
    Office of Pesticide Programs
    Environmental ProCection Agency
    401 M St., SW.
    Washington, D.C.  20460
    Phone No. (703)-557-3675

The address for submission to the Office of Compliance Monitoring
is :

    Laboratory Data Integrity Program
    Office of Compliance Monitoring (EN-342)
    Environmental Protection Agency
    401 M St., SW.
    Washington, D.C.  20460

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                                                            (SO)
                                          Appendix II-l

              Guide to Use of This Bibliography


1.  CONTENT OF BIBLIOGRAPHY.  This bibliography contains
    citations of all studies considered relevant by EPA in
    arriving at the positions and conclusions stated elsewhere
    in the Standard.  Primary sources for studies in this
    bibliography have been the body of data submitted to EPA
    and its predecessor agencies in support of past regulatory
    decisions.  Selections from other sources including the
    published literature, in those instances where they have
    been considered, will be included.

2.  UNITS OF ENTRY.  The unit of entry in this bibliography
    is called a "study."  In the case of published materials,
    this corresponds closely to an article.  In the case of
    unpublished materials submitted to the Agency, the Agency
    has sought to identify documents at a level parallel to
    the published article from within the typically larger
    volumes in which they were submitted.  The resulting
    "studies" generally have a distinct title (or at least a
    single subject), can stand alone for purposes of review,
    and can be described with a conventional bibliographic
    citation.  The Agency has attempted also to unite basic
    documents' and commentaries upon them, treating them as a
    single study.

3.  IDENTIFICATION OF ENTRIES.  The entries in this bibliography
    are sorted numerically by "Master Record Identifier,"  or
    MRID, number.  This number is unique to the citation,  and
    should be used at any time specific reference is required.
    It is not related to the six-digit "Accession Number"
    which has been used to identify volumes of submitted
    studies; see paragraph 4(d)(4) below for a further explana-
    tion.  In a few cases, entries added to the bibliography
    late  in the review may be preceded by a nine-character
    temporary identifier.  These entries are listed after
    all MRID entries.  This  temporary identifier number is
    also  to be used whenever specific reference is needed.

4.  FORM  OF ENTRY.  In addition to the Master Record Identifier
    (MRID), each entry consists of a citation containing
    standard elements followed, in the case of material
    submitted to EPA, by a description of the earliest known
    submission.  Bibliographic conventions used reflect the
    standards of the American National Standards Institute
    (ANSI), expanded to provide for certain special needs.

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                                                       (51)
                                   Appendix II-l (continued)

a.  Author.  Whenever the Agency could confidently identify
    one, the Agency has chosen to show a personal author.
    When no individual was identified, the Agency has
    shown an identifiable laboratory or testing facility
    as author.   As a last resort, the Agency has shown
    the first submitter as author.

b.  Document Date.  When the date appears as four digits
    with no question marks, the Agency took it directly
    from the document.  When a four-digit date is followed
    by a question mark, the bibliographer deduced the
    date from evidence in the document.  When the date
    appears as  (19??), the Agency was unable to determine
    or estimate the date of the document.

c.  Title.  In  some cases, it has been necessary for
    Agency bibliographers to create or enhance a document
    title.  Any such editorial insertions are contained
    between square brackets.

d.  Trailing Parentheses.  For studies submitted to the
    Agency in the past, the t'railing parentheses include
    (in addition to any self-explanatory text) the fol-
    lowing elements describing the earliest known submission:

    (1)  Submission Date.  The date of the earliest known
         submission appears immediately following the word
         "received."

    (2)  Administrative Number.  The next element,
         immediately following the word "under," is the
         registration number, experimental use permit
         number, petition number, or other administrative
         number associated with the earliest known submission,

    (3)  Submitter.  The third element is the submitter,
         following the phrase "submitted by."  When
         authorship is defaulted to the submitter, this
         element is omitted.

    (4)  Volume Identification (Accession Numbers).  The
         final  element in the trailing parentheses
         identifies the EPA accession number of the volume
         in which the original submission of the study
         appears.  The six-digit accession number follows
         the symbol "CDL," standing for "Company Data
         Library."  This accession number is in turn
         followed by an alphabetic suffix which shows the
         relative position of the study within the volume.
         For example, within accession number 123456, the
         first  study would be 123456-A; the second, 123456-
         B; the 26th, 123456-Z; and the 27th, 123456-AA.

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                                                                 (52)
                                           Appendix II-2
MRID No.


00100362
GS0220-001
GS0220-002
GS0220-003
                          BIBLIOGRAPHY
West, B.  (1962) To  Investigate  (a) the Oral Toxi-
clty and  (b) Eye and Skin Irritation Potential of
the Subject Material in Order to Comply with the
Safety Labeling Requirements of the Federal Sub-
stances Labeling Act: Laboratory No. PT62-28.
(Unpublished study  received Jun 19, 1967 under
8429-2; prepared by Rosner-Hixson Laboratorie,
submitted by Carus  Chemical Co., Inc. LaSalle,
111.; CDL: 227435-A).

U.S.EPA.  1975.  Report on the Toxicitry of Potas-
sium Permanganate 100% active ingredient to blue-
gill sunfish.  (US.EPA, Chemical and Biological
Investigations Branch, Beltsville, Maryland,
Static-jar, 8/21/75. Unpublished report).

U.S.EPA.  1975.  Report on the Toxicitry of Potas-
sium Permanganate 100Z active ingredient to blue-
gill sunfish.  (US.EPA, Chemical and Biological
Investigations Branch, BeltsvilLe, Maryland,
Flow-through, Test  No.  MB  403, 8/21/75, Unpub-
lished Report).

Griffen, J. and C. Thompson. September 25, 1981.
Acute Toxicity of Cairox FF to Bluegill Sunfish
(Lepomis macrochirus).  Study #27919.   Prepared
by Analytical Bio-Chemistry Laboratories, Inc.
Submitted to Carus Chemical Co.  La Salle, 111.
EPA Accession No. 253711.

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                                                                           Q.Vtg ASSrS.*, •»;  <;,

                 F1FHA SECTION 3(CJ(2)(S) SUMMARY SHEET
, APPUCANTS NAME
I
                                                                                   DATE GUIDANCE DOCUMENT ISSUES
   Witn rooict to mi rtotiirwntnt to aibmrt "gtntnc" dm imooatf by tin F1FRA anon 3(C)(2)(8) none* eoramtd m tni rafvmctd
   Guidinea Oocunnm. I am mending in tni following rntnntn
        1. I will •ibfflit am in • flmrty tnarmr 10 mtah v\t following rtquinmiira. If tfti an nreetduno I will \im drntn from (or in not
          B«ifnd mi (tit fltaatntion Cutdtiinct or ait Protocol* eanntmd in tfit Rtpore of Exoirt Grouos to tn« Chtmieau Grouo, OEC3
          Chtniali Tifong Prognntini, I cidosi tttt protocol! ttut I wiil im:
     _L I hivttnttnd into in igrttmtnt witn ont or mort otntr rvgotnnn unatr FIFBA action 3
-------
                                                                               QMS
                                                                                                                  (54)
CERTIFICATION OF ATTEMfTTO ENTER
INTO AN AGREEMENT WITH OTHER REGISTRANTS
To mtfry. «rT*y£ii *>****,) «* DEVELOPMENT OF DATA
1. 1 am duty autrwnred M res»**ant OH tellowtng finn(il who art wbiect to me reouire-
ment* of a Notice unoer PIPRA Section 3(e)<2)(8) contained in a Guidance Document
to suDmrt data concerning tne active ingrediam:
NAMf Of FIRM




(This ttrm or arouo o* tirrm » rtterreo 10 oetow ai "my firm".)

ACTIVE INGMEOlKNT
lUk COMPANY NUMBER

J
!


2. My firm is willing to dweloo ant submit the data u rwuirad by that Nonce, if nteeoary. However, my firm would orefar to ente-
   into «n aore«ment wirn one or  more otner registrants to develoo jointly, or to share in me eon of devetooing. me following reoyirec
   itemi or data:
1. My firm hn oftand m wming to inter into such an agreement Coo in of The often m attached. Thn offerees imvecaoit and mtluaed in offc* TC 2-
   Pound by en arartmion aecuen undir FIFfiA Section 31e)!2)lB)(iii) if final igrternem en all nrmt eauld not Bi nacnea otnerwise. Tnu otter w» mtti
   n tnt fallowing ftrm(i) on tni following eatels):
                                     MAMt
                                               FIRM
                                                                DATt O*
ngwevy  none o* mote firmm
oteemv otter
4. My firm reouests mat EPA not cusoend trie regittration{s) of my firm's prooucilsl, if any of tne firrru nimed in aaragnan (3i
   have agreed to suomtt tne dan lined in oaragnor) (2) above in accordance wnn me Notice. I unoernand  EPA will arometiy irrar
   me  wnctner my firni  muit fuomit data  to  avoid susoenoon of itt reg«tration
-------
                                                                          (55)
                                                    Appendix III-l
EPA Registration No.
 PRODUCT SPECIFIC  EHTA REPORT



	Guidance  Document for_



                          Date
Registration
Guideline No.
§158.20
PRODUCT
CHEMISTRY
61-1
61-2
61-3
62-1
62-2
62-3
63-2
63-3
63-4
63-5
63-6
63-7
63-8
63-9
63-10
63-11
63-12
Name of Test

Identity of
ingredients
Statement of
composition
Discussion of
formation of
ingredients
Preliminary
analysis
Certification of
limits
Analytical methods
for enforcement
limits
Color
Physical state
Odor
Melting point
Boiling point
Density, bulk-
density, or
specific gravity
Solubility
Vaoor pressure
Dissociation
constant
Octanol/water
partition
coefficient
pK
Test not
required
for my
product
listed
above
(check
below)


















I am complying with
data requirements by
Citing MRID#







Submit-
ting
Data
(At-
tached)



























(For EPA Use Only)
Accession Numbers
Assianed



















-------
                      (56)
Appendix III-1 (continued)
Registration
Guideline No.
63-13
63-14
63-15
63-16
63-17
63-18
63-19
63-20
63-21
§158.135
TOXICOLOGY
81-1
81-2
81-3
81-4
81-5
81-6
Name of Test
Stability
Oxidizing/reducing
reaction
Flaimiability
Explodability
Storage stability
Viscosity
Miscibility
Corrosion
characteristics
Dielectric break-
down voltage

Acute oral LD-50,
rat
Acute dermal
LD-50
Acute inhalation,
LC-50 rat
Primacy eye
irritation, rabbit
Primary dermal
irritation
Dermal sensitiza-
tion
Test not
required
for my
product
listed
above
(check
below)
















I am complying with
data requirements by
Citing MRIDft
















Suonit-
ting
Data
(At-
tached)
















(For EPA Use Only)
Accession Numbers
Assigned

















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                                                                                   (57)
                          APPENDIX IV  -1
§ 1*2-10                                 Title 40—Protection of Environment
                                     0182.10 Labeling rcquirmenu.
                                      (a)  General—41)  Contents  of  tfu
                                     label  Every pesticide products shall
                                     bear a label containing  the informa-
                                     tion specified by the Act and the regu-
                                     lations in this Pan. The  contents of a
                                     label must  show  clearly and promi-
                                     nently the following:
                                      (1) The name, brand, or trademark
                                     under vhich the product is sold as pre-
                                     scribed in paragraph (b) of this sec-
                                     tion:
                                      (11) The name  and address of the
                                     producer, registrant, or  person  for

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                                     Appendix IV-1  (continued)
                                                                                  (58)
Oiapte* I—Ifivironmentol Protection Agency
                            § 167.10
whom produced u prescribed in paia-
graph (O of this section:
  (Ul) The net contents  as prescribed
In paragraph (d) of this section:
  dv>   The    product   registration
number as prescribed in paragraph (e>
or this section:
  (v>  The  producing  establishment
number as prescribed in paragraph (f)
or this section:
   Not be obscured or crowded.
  (3) Language to be tuetf. All required
label or labeling text shall appear In
the  English  language.  However,  the
Agency may  require or  the applicant
may  propose additional text in other
languages as Is considered necessary to
protect  the  public. When additional
text in another language is necessary.
all labeling  requirements will be ap-
plied equally to both the English and
other-language versions  of the label-
ing.
  (4) Placement of Label—
-------
                                      Appendix  IV-1  (conciaued)
                                                                                    (59)
 § 1*2.10

   (v> Any statement directly or indi-
 rect y implying that the pesticide or
 device a recommended or endorsed by
 any agency of the  Federal  Govern-
 ment:
   (vt) The name of a pesticide which
 contains two or more principal active
 ingredient* if the name suggests one
 or more  but not  all  such principal
 active ingredients  even  though  the
 names  of the other  ingredients are
 stated elsewhere In the labeling:
   evil) A true statement used in such a
 way as to give a false or misleading im-
 pression 10 the purchaser.
   (vUl) Label disclaimers which negate
 or detract from labeling statements re-
 quired under the Act and these regula-
 tions:
   (Ixi Claims as to the safety of the
 pesticide  or its ingredients, including
 statements such as "safe." "nonpoison-
 ous." ••oomajunous,"  "harmless"  or
 "nontoxic to humans  and pets" with
 or without such a qualifying phrase as
 "when used as directed": and
  (z) Non-numeneal and/or compara-
 tive statements on the safety of the
 product, including but not limited to:
  (A) "Contains all natural  ingredi-
 ents":
  (B) "Among the least toxic chemi-
 cals known"
   Name and address of producer.
 registrant,  or  person  for whom  pro-
 duced. An  unqualified name and  ad-
 dre-s  given on the label shall be  con-
 sidr red as the name and address of the
 pn cucer. If the registrant's name ap-
 pears on the label and the registrant is
 not the producer, or if the name of the
 person- for whom the  pesticide  was
 produced appears on the label, it must
 be qualified by appropnate wording
 such as "Packed for •  • V "Distribut-
 ed by ••  V or "Sold by' • •" to show
 that the name is not that of the  pro-
 ducer.
   (d) Net wtiotit or  measure of  con-
 tentt.  (1) The  net weight or measure
 of content shall be exclusive of wrap-
 pers or other  materials and shall be
 the  average content  unless  explicitly
 stated as a minimum quantity.
   (2) If the pesticide  is a liquid, the
 net  content  statement  shall  be  in
 tens  of liquid measure at 68' F <20'C)
 and shall be expressed in conventional
 American units of  fluid ounces, pints.
 quarts, and gallons.
   (3) If the pesticide is solid or semi-
 solid,  viscous or pressurized, or  Is a
 mixture of  liquid  and solid, the  net
 content statement shall be in terms of
 weight  expressed   as  avoirdupois
 pounds and ounces.
   (4) In all cases, net content shall be
 stated  in terms of the largest suitable
 units. Le.. "1 pound 10 ounces" rather
 than "26 ounces."
  (5) In addition to the required units
 specified,  net  content  may  be  ex-
 pressed in metric units.
  (6) Variation  above  *<>«"»»»»* eon.
 tent or around an average is permissi-
 ble only to  the extent that it repre-
sents deviation  unavoidable  in good
manufacturing   practice.   Variation
below a stated mi^^tim is not permit-
ted. In no case shall the average con-
tent of the packages in a shipment fall
below the stated average content.
    Product   registn.ti.on   number.
The  registration number assigned to
the pesticide product  at the tune of
registration snail appear on the label.
preceded by the phrase "EPA Regis-
tration No.." or the phrase "EPA Reg.
No." The registration number shall be
set In type of a size and style similar to

-------
                                       Appendix  IV-1  (continued)
                                                                                     C60)
 Chapter I—Environmental Pratactian Agency
                            § 162.10
 other print on  that part of the label
 on which it appears and shall run par-
 allel to it. The registration number
 and  the  required  identifying phrase
 shall not appear in such a  manner as
 to  suggest or imply  recommendation
 or  endorsement of  the product by the
 Agency.
  (f) Producing establishments regis-
 tration number. The  producing estab-
 lishment  registration number preced-
 ed  by the phrase "EPA Est.". of the
 final establishment at which the prod-
 uct was produced may appear in any
 suitable location on the label or imme-
 diate container.  It must appear on the
 wrapper or outside container of the
 package if the EPA establishment reg-
 istration  number on  the   immediate
 container  cannot  be   clearly  read
 through such wrapper or container.
  (g) Ingredient statement—(.\~> Gener-
 al.  The label of  each pesticide product
 must bear a statement which contains
 the name and percentage by weight of
 each active ingredient, the  total per-
 centage by weight of all inert ingredi-
 ents: and  If the pesticide contains ar-
 senic in any form, a statement of the
 percentages of total and water-soluble
 arsenic calculated  as  elemental ar-
 senic. The active ingredients must be
 designated by the term "active ingredi-
 ents" and the inert ingredients by the
 term "Inert ingredients." or  the singu-
 lar  forms  of these terms when appro-
 priate.  Both terms shall  be in the
 same type size, be aligned to the same
 margin and be equally prominent. The
 statement "Inert Ingredients, none" is
 not required for pesticides which con-
 tain  100  percent active ingredients.
 Unless the ingredient  statement is a
 complete analysis of the pesticide, the
 terra "analysis"  shall not be used as a
 heading for the ingredient statement.
  (2) Position of ingredient statement.
 (i)  The ingredient  statement is nor-
 mally required  on the front panel of
the label. If there  is an outside con-
 tainer or  wrapper through  which the
 ingredient statement cannot  be clearly
read, the  ingredient statement must
also appear on such outside container
or wrapper. If the size or form of the
package  makes   it  impracticable to
place the  ingredient statement on the
front panel of  the label, permission
 may be  granted  for the  ingredient
 statement to appear elsewhere.
  (ii) The text of the ingredient state-
 ment  must  run parallel with  other
 text on the panel on which it appears.
 and must be clearly distinguishable
 from and must  noc be placed in  the
 body of other text.
  (3) Names to  be  tued in ingredient
 statement. The name  used for  each in-
 gredient  shall  be   the  accepted
 common  name.  If  there  Is one.  fol-
 lowed  by  the  chemical  name.  The
 common name may be used alone only
 if it is well known. If no common name
 has been  established,  the chemical
 name alone shall be  used. In  no case
 will the use of a trademark or  proprie-
 tary name  be permitted  unless such
 name has been accepted as a common
 name by the Administrator under  the
 authority of Section 2S(cX6).
  (4) Statements of percentages.  The
 percentages  of  Ingredients shall be
 stated In terms of weight-to-weight.
 The sum of percentages of the active
 and the inert ingredients shall be 100.
 Percentages shall not be expressed by
 a range of values such as "22-25%." If
 the  uses of the  pesticide  product  are
 expressed as weight of active  ingredi-
 ent  per unit area, a statement of  the
 weight of active ingredient per unit
 volume of the  pesticide  formulation
 shall also appear  in the ingredient
 statement.
  (5) Accuracy of stated percentages.
 The percentages given shall be as pre-
 cise  as possible reflecting  good manu-
 facturing practice. If there may be  un-
 avoidable variation  between manufac-
 turing batches,  the value  stated  for
 each active  ingredient  shall  be  the
 lowest  percentage  which  may  be
 present.
  (6) Deterioration. Pesticides  which
 change  in chemical composition sig-
 nificantly must meet the following la-
 beling requirements:
  (1) In eases where it Is  determined
 that a pesticide formulation changes
chemical  composition  significantly.
 the  product must bear the following
statement In a prominent position on
the  label: "Not  for sale or  use after
 [date]."
  
-------
                                     Appendix  IV-1  (continued)
                                                                                  (61)
 § 16X10

   (7) Inert ingredients. The Adminis-
 trator may require the name of any
 inert mgredienus) to  be  listed in the
 Ingredient statement if he determines
 that such  mgredienus)  may  pose  a
 hazard to man or the environment.
   (h)  Warning*  and  precautionary
 statements.  Required  warnings  and
 precautionary  statements concerning
 the  general  areas  of  lexicological
 hazard including  hazard  to children.
 environmental hazard, and physical or
 chemical hazard fall into two groups:
 those  required on  the  front panel of
          Title 4O—Protection of Environment

       the  labeling  and those  which  may
       appear elsewhere. Specific  require-
       ments concerning content, placement.
       type  size, and prominence  are  given
       below.
         (1) Rewind front panel statements.
       With  the  exception  of  the  child
       hazard warning statement, the text re-
       quired on the front panel of the label
       is  determined by the Toxicity  Catego-
       ry of the pesticide. The category is as-
       signed on  the  basis  of the  highest
       hazard shown by any of the  indicators
       in the table below:
            uoieaM
             •"»'•«.
            UDBM
           i Us town
             "•"ft
M l«u 900 mt/tgj from MO mm MOO mg/
  (1) Human hazard signal vord—
Toxintv Category I. All pestiade prod-
ucts meeting the criteria of Toxicity
Category I shall bear on  the front
panel the signal word "Danger." In ad-
dition IT the product was assigned to
Toxicity Category I on the basis of its
oral inhalation or dermal toxicity (as
distinct  from  skin  and eye local ef-
fects) the word "Poison" shall  appear
in red on  a background of distinctly
contracting color and the  skull and
crossbones shall appear in Immediate
proximity to the word "poison."
  (B)  Toxieity  Category II. All pesti-
cide products  meeting the criteria of
Toxicity Category n shall bear on the
front  panel the signal word "Warn-
ing."
  (C)  Toxintv  Category III. All pesti-
cide products  meeting the criteria of
Toxicity Category m shall bear on
the front panel the signal word "Cau-
tion."
  (D)  Toxieity  Category IV. All pesti-
ade products  meeting the criteria of
Toxicity Category IV shall bear on the
front  panel the signal word "Caution."
         (£)  Use of signal words. Use of any
       signal worries) associated with a higher
       Toxicity  Category  is  not permitted
       except when the Agency determines
       that such labeling is necessary to pre-
       vent unreasonable adverse effects on
       man or the environment. In no  case
       shall  more than one human hazard
       signal word appear on the front panel
       of a labeL
         (11) Child hazard warning. Every pes-
       tiade  product label  shall bear on the
       front panel the statement "keep out of
       reach   of children."  Only  in  cases
       where  the likelihood of contact with
       children  during  distribution, market-
       ins, storage or use is demonstrated by
       the applicant to  be extremely remote.
       or if the nature of the pesticide is such
       that it is approved for use on infants
       or small children, may the Administra-
       tor waive this requirement.
         (IK)  Statement of practical  treat-
       m«ni—
-------
                                      Appendix  IV-i  (continued)
                                                                                  (62)
Chapter I—environmental Protection Agency
                            § 162.10
basis of oraL inhalation or dermal tox-
teity.   The  Agency  nay.  however.
permit  reasonable  variations  in the
placement of the statement of practi-
cal treatment  is some reference such
as "See statement  of practical treat-
ment  on back panel" appears on the
front  panel near the word "Poison"
and the skull and crossbones.
  (B)  Other toxicity categories. The
statement of practical treatment is not
required on the  front panel except as
described in paragraph (hxlXiiiXA) of
this section. The applicant may. how.
ever, include such a front panel state-
ment  at his  option.  Statements of
practical treatment are.  however, re-
quired  elsewhere   on the  label  in
accord with paragraph (hX2)  of  this
section if they do  not appear on the
front paneL
  (iv)  Placement and prominence. All
the require front panel warning state-
menu  shall be  grouped  together on
the label, and  shall appear with suffi-
cient  prominence   relative  to other
front panel text  and graphic material
to make them  unlikely  to be over-
looked under customary conditions of
purchase and use. The following table
shows the minimum type size require-
ments  for  the  front  panel warning
statements on various sizes of labels
    S*10_
    10 10 19 ,
 1 I
10 I
12 I
'•I
It I
                                  *
                                  10
                                  12
  (2) Other required warnings and pre-
cautionary statements* The warnings
and  precautionary  statements  as re-
quired below shall appear together on
the label  under the general heading
"Precautionary   Statements"    and
under  appropriate  subheadings  of
"Hazard to Humans and Domestic Ani-
mals." "Environmental Hazard"  and
"Physical or Chemical Hazard."
  (1) Hazard, to humans and domestic
animals. (A) Where a hazard exists to
humans or domestic ""•"•'• precau-
tionary statements  are required indi-
cating  the particular  hazard,  the
routets) of exposure and the precau-
tions  to be taken to avoid accident.
Injury  or damage. The precautionary
paragraph  shall be immediately  pre-
ceded by the appropriate hazard signal
word.
  (B) The following table depicts typi-
cal precautionary  statements.  These
statements must  be modified or ex-
panded to reflect specific hazards.
               Or*
                     MHOMO Immta or
        .  mrouan iuil Do not gnM» «OT [«•
        !  mHj Oo not o* « •«•>. an

        I  auma.1
        <  mugn m* «M) Do not
              inM) Oenoi an «
  (ii> Environmental hazards. Where a
hazard exists to non  target organisms
excluding  humans and domestic  ani-
mals, precautionary statements are re-
quired  stating  the  nature  of  the
hazard and  the appropriate precau-
tions  to  avoid  potential  accident.
injury  or damage.  Examples  of  the
hazard statements  and  the circum-

-------
                                       Appendix IV-1  (continued)
                                                                                   (63)
 § 142.10

 nances under which they are required
 follow:
  (A) II a pesticide intended for  out-
 door us* contains an active ingredient
 with a  mammalian acute onl LD« of
 100  or less, the statement "This Pesti-
 cide is Toxic to Wildlife" u required.
  (B) If a pesticide intended for  out-
 door use contains an active ingredient
 with a fish acute LC. of 1 ppra or  less.
 the statement "This Pesticide u Toxic
 to Pish" u required.
  (C) If a pesticide Intended for  out-
 door use contains an active ingredient
 with an avian  acute oral LD. of 100
 ing/kg  or  less, or a subacute dietary
 LC. of  500 ppra or less, the statement
 "This Pesticide u Toxic to Wildlife" is
 required.
  (D) If either accident history or field
 studies  demonstrate  that  use  of  the
   Title 40— Protection of Environment

 pesticide may  result  in  fatality  10
 birds, fish or mammals, the statement
 "This  pesticide is extremely toxic  to
 wildlife (fish)" u required.
  (£) Por oses  involving foliar applica-
 tion to agricultural crops, foresu.  or
 shade  trees, or  for  mosquito  abate-
 ment treatments, pesticides  toxic  to
 pollinating insects must bear appropri-
 ate label cautions.
  (F) Por all outdoor uses other than
 aquatic  applications  the  label  must
 bear the caution "Keep out of lakes.
 ponds or streams. Do not contaminate
 water by cleaning of equipment or dis-
 posal of wastes."
  (ill)  Prtimeal or  chemical  hazards.
 Warning statements on the flammaoil-
 ity or  explosive characteristics  of the
 pesticide are required as follows:
                            IAI
                                                         130" r mm,
                                                   Oo *•»<•§ or
                                         Do not ownn or
                                         asm m* IX' * "«T
  (13 Directions for Uie- Placement of  directions  for use.
Directions may appear on any portion
of the label provided that they are
conspicuous enough to be easily read
by the user of the pesticide product.
Directions  for  use  may  appear  on
printed or graphic matter  which  ac-
companies the pesticide provided that:
  (A) If required by the Agency, such
printed or graphic matter is securely
attached to each package of the pesti-
cide,  or  placed  within  the  outside
wrapper or bar.
  (B) The label bears *  reference to
the directions for use in accompanying
leaflets or circulars, such as "See  di-
rections in the enclosed circular" and
  (C) The Administrator determines
that It is not necessary for such direc-
tions to appear on the label.
  {ill) Exceptions  to requirement for
direction  for use—
-------
                                     Appendix IV-1  (continued)
                                                                                  (64)
 Chapter I—Environmental Protection Agency
                             § 142.10
 for use only by manufacturers of prod-
 uct*  other than pesticide products in
 their regular manufacturing processes.
 provided that:
  U) The  label clearly shows that the
 product is intended for use only in
 manufacturing processes and specifies
 the typets) of products involved.
  (2) Adequate  information such  as
 technical  data sheets  or bulletins. Is
 available to the trade specifying  the
 type  of  product   involved  and   its
 proper  use in  manufacturing process-
 es:
  (31  The  product  will not come Into
 the hands  of the general public except
 after incorporation into flushed prod-
 ucts: and
  <4)  The  Administrator determines
 that such  directions are not necessary
 to prevent unreasonable  advene ef-
 fects on man or the environment.
  (B) Detailed directions for use  may
 be omitted from the '•*«•""> of pesti-
 cide products for which sale is limited
 to physicians,  veterinarians, or drug-
 gists, provided  that:
  (J> The label clearly  states that the
 product is  for  use only by  physicians
 or veterinarians:
  (2)  The   Administrator determines
 that such directions are not necessary
 to prevent unreasonable advene ef-
 fects on man or the environment: and
  (J) The  product is also a drug and
 regulated under the provisions of the
 Federal Food. Drug and Cosmetic Act.
  (C)  Detailed  directions for use may
 be omitted from  the labeling of pesti-
 cide  products which are intended for
 use only by formulaton in preparing
 pesticides for sale to the public,  pro-
 vided that:
  
-------
                                      Appendix  IV-1  (continued)
                                                                                (65)
 §162.11

  <£) For restricted  use pesticides, a
 statement that the pesticide may be
 applied under the direct supervision of
 a certified applicator who is not phys-
 ically present at the site of application
 but  nonetheless  available  to  the
 person  applying  the pesticide,  unless
 the Agency  has  determined that the
 pesticide  may  only be applied  under
 the direct supervision of a certified ap-
 plicator who is physically present.
  (F)  Other  pertinent  information
 which the  Administrator determines
 to  be necessary for the protection of
 man and the environment.
  (j) Statement of U*e Classification.
 By October 22. 1976. all pesticide prod-
 ucts must bear on their labels a state-
 ment of use  classification as described
 in paragraphs (JX1) and (2) of this sec-
 tion, Any pesticide product for  which
 some uses are classified for general use
 and others for restncted use shall be
 separately labeled according to the la-
 beling standards  set forth in this  sub-
 section, and shall be marketed as sepa-
 rate products with different registra-
 tion numbers,  one bearing directions
 only for general  use
-------
                                                                   APPENDIX IV-2
IABF.LING REQUIREMENTS OF TUB FIFRA, AS AMENDED

ITEM
1
2
3
4
5
6A
61)
7
7A
711

LABEL ELEMENT
Product name
Company name
and address
Net contents
EPA Reg. No.
EPA Est. No.
Ingredients
statement
Pounds/gallon
statenent
Front panel
precautionary
statements
Keep Out of Reach
ot Children
(Child hazard
warning)
Signal word
APPLICABILITY
OF REQUIREMENT
All products
All products
All products
All products
All products
All products
Liquid products
where dosage
given as Ibs.
ai/unit area
All products
All products
All products
PLACEMENT
REQUIRED
Front panel
None
None
None
None
Front panel
Front panel
Front panel
Front panel
Front panel
ON LABEL
PREFERRED
Center front
panel
Dot ton front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel,
immediately
before or
following
Reg. No.
Immediately
following
product name
Directly below
the main
ingredients
statement

Above signal
word
Immediately
below child
hazard
warning

COMMENTS

If registrant is not the producer, must
be qualified by "Packed for . . .,"
"Distributed by. . .," etc.
May be in metric units in addition to
U.S. units
Must be in similar type size ami run
parallel to other type.
May appear on the container instead of
the label.
Text must run parallel with other text
on the panel.

All front panel precautionary statements
must be grouped together, prelurahly
blocked .
Note type size requirements.
Note type size requirements.

-------
APPENDIX IV-2 (continued)

ITEM
7C
7D

7E
8
8A
(II)

LABEL EIJFMENF
Skull & cross-
Ijones and word
POISON (in red)
Statement of
practical
treatment

Referral
statement
Side/back panel
precautionary
statements
Hazards to
humans ami
domestic
animals
Environmental
hazards
APPLICABILITY
OF RRQUIREMENF
All products
which are Cat-
egory I based
on oral, der-
mal, or inhala-
tion toxicity
All products
in Categories
I, II, and III

All products
where pre-
cautionary
labeling
appears on
other than
front panel.
All products
All products
in Categories
I, li, aivl III
All prnducl.s
PU\CEMENT
REQUIRED
Front panel
Category I:
Front panel
unless refer-
ral statement
is used.
Others:
Grouped with
side panel
precautionary
statements.
Front panel
None
None
None
ON LABEL
PREFERRED
Both in close
proximity to
signal word
Front panel
for all.


Top or side
of back panel
preceding
directions
for use
Same as above
Same as above

COMMENTS




Must be grouped under the headings in
8A, 8B, and 8C; preferably blocked.
Must be preceded by appropriate signal
word.
Environmental hazards include IJGO
caution where ajipli cable.

-------
APPENDIX IV-2 (continued)
ITEM
8C
9A
9C
10A
LOG
10L>
LABEL ELEMENr
Physical or
chemical
hazards
Restricted
block
Misuse
statement
Reentry
statement
Storayo and
disposal block
Directions
for use
APPLICABILITY
OF REQUlREMhXr
All pressurized
products, others
with flash
points under
150°F
All restricted
products
All products
All
cholinesterase
inhibitors
All products
All products
PLACEMENT ON LABEL
REQUIRED
None
Top center
of front
panel
Immediately
following
heading of
directions
Cor use
In the
directions
for use
In the
directions
for use
None
PREFERRED
Same as above
Preferably
blocked

Immediately
after misuse
statement
Immediately
before
specific
directions
for use or
at the end of
directions
for use
None
COMMENTS

Includes a statement of the terms of
restriction. The words "RESTRICTED USE
PESTICIDE" must be same type size as
signal word.


Must be set apart and clearly distin-
guishable from from other directions
for use.
May be in metric as well as U.S. units
                          oo

-------
                                                              (69)
                                                   Appendix IV-3
                    PHYSICAL-CHEMICAL HAZARDS
Criteria
I.  Pressurized Containers

    A.  Flashpoint at or below
        20°F; or if there is a
        flashback at any valve
        opening.
    B.  Flashpoint above 20°F
        and not over 80°F; or
        if the flame extension
        is more than 18 inches
        long at a distance of
        6 inches from the
        valve opening.

    C.  ALL OTHER PRESSURIZED
        CONTAINERS
II.  Non-Pressurized Containers

    A.  Flashpoint at or below
        20°F.
    B.   Flashpoint  above 20°F
        and not over 80°F.

    C.   Flashpoint  over 80°F
        and not over 150°F.

    D.   Flashpoint  above
        150°F.
Required Label Statement
Extremely flammable.
Contents under pressure.
Keep away from fire, sparks,
and heated surfaces.  Do not
puncture or incinerate
container.  Exposure to
temperatures above 130°F
may cause bursting.

Flammable.  Contents under
pressure.  Keep away from
heat, sparks, and flame.  Do
not puncture or incinerate
container.  Exposure to
temperatures above 130°F
may cause bursting.

Contents under pressure.
Do not use or store near
heat or open flame.  Do not
puncture or incinerate
container.  Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable.  Keep
away from fire, sparks, and
heated surfaces.

Flammable.  Keep away from
heat and open flame.

Do not use or store near
heat and open flame.

None required.

-------
                                                             (70)
                                                Appendix IV-4

        STORAGE  AND DISPOSAL INSTRUCTIONS  FOR  PESTICIDES

All products  are  required  to bear  specific  label  instructions
about storage and  disposal.   Storage and  disposal instructions
roust be grouped together  in the  directions  for  use portion of
the label under the  heading STORAGE AND DISPOSAL.  Products
intended solely for  domestic use need  not include the heading
"STORAGE AND  DISPOSAL."  The STORAGE AND  DISPOSAL heading
must appear in  the minimum type  size listed below:
 Size of label
 front panel  in
 square inches
 Required type  size
 for  the  heading
 STORAGE  AND DISPOSAL
(all  capitals)
 10 and under	6 point
 Above 10 to 15	8 point
 Above 15 to 30	10 point
 Over 30	12 point
Storage and disposal  instructions must be set apart and
clearly distinguishable  from other directions for use.
Blocking storage and  disposal statements with a solid line is
suggested as a means  of  increasing their pcontinence.

A.  Storage Instructions;

All product labels are required to have appropriate storage
instructions.  Specific  storage instructions are not prescribed
Each registrant must  develop his own storage instructions,
considering, when applicable, the following factors:

1.  Conditions of storage that.might alter the composition or
    usefulness of the pesticide.  Examples could be temperature
    extremes, excessive  moisture or humidity, heat", sunlight,
    friction, or contaminating substances or media.

2.  Physical requirements of storage which might adversely
    affect the con-tainer of the product and its ability to
    continue to function properly.  Requirements might include
    positioning of the container in storage, storage or damage
    due to stacking,  penetration of moisture, and ability to
    withstand shock or friction.

3.  Specifications for handling the pesticide container,
    including movement of container within the storage area,
    proper opening and "closing procedures (particularly for
    opened containers),  and measures to minimize exposure
    while opening or  closing container.

-------
                                                             C71)
                                                 Appendix IV-4
                                                 (continued)

4.  Instructions on what to do if the container is damaged in
    any way, or if the pesticide is leaking or has been
    spilled, and precautions to minimize exposure if damage occurs

5.  General precautions concerning locked storage, storage in
    original container only, and separation of pesticides
    during storage to prevent cross-contamination of other
    pesticides, fertilizer, food, and feed.

6.  General storage instructions for household products should
    emphasize storage in original container and placement in
    locked storage areas.

B.  Pesticide Disposal Instructions;

The label of all products, except those intended solely for
domestic use, must bear explicit instructions -about pesticide
disposal.  The statements listed below contain the exact wording
that must appear on the label of these products:

1.  The labels of all products, except domestic use, must
    contain the statement, "Do not contaminate water, food,
    or feed by storage or disposal.'
H
    Except those products intended solely for domestic use,
    the labels of all products that contain active ingredients
    appearing on the "Acutely Hazardous" Commercial Pesticide
    Products List (RCRA "E" List)  at the end of this appendix
    or are assigned to Toxicity Category I on the basis of
    oral or dermal toxicity, skin or eye irritation potential,
    or Toxicity Category I or II on the basis of acute inhala-
    tion toxicity must bear the following pesticide disposal
    statements

    "Pesticide wastes are acutely hazardous.  Improper dis-
    posal of excess pesticide, spray mixture, or rinsate is
    a violation of Federal Law.  If these wastes cannot be
    disposed of by use according to label instructions,
    contact your State Pesticide or Environmental Control
    Agency, or the Hazardous Waste representative at the
    nearest EPA Regional Office for guidance."

    The labels of all products, except those intended for
    domestic use, containing active or inert ingredients
    that appear on the "Toxic" Commercial Pesticide Products
    List (RCRA "F" List) at the end of this appendix or
    presently meet any of the criteria in Subpart C, 40 CFR
    261 for a hazardous waste must bear the following pesticide
    disposal statement:

-------
                                                              (72)
                                                 Appendix IV-4
                                                 (continued)

    "Pesticide  wastes are  toxic.   Improper disposal of excess
    pesticide,  spray mixture*  or  rinsate is a violation of
    Federatl  Law.   if these wastes  cannot be disposed of by
    use according  to label instructions, contact your State
    Pesticide or Environmental  Control Agency, or the Hazardous
    Waste  representative at  the nearest EPA Regional Office
    for guidance."

    Labels for  all other products, except those intended for
    domestic use, must bear  the following pesticide disposal
    statement:

    "Wastes  resulting from the  use of this product may be
    disposed of on site or at an approved waste disposal
    facility."

3.  Products intended for domestic use only must bear the
    following disposal statement:  "Securely wrap original
    container in several layers of newspaper and discard in
    trash."

C.  Container Disposal Instructions

    The label of each product must bear container disposal
    instructions appropriate to the type of container.

    1.  All products intended for domestic use must bear one
        of the  following container disposal statements:
Container Type
Statement
Non-aerosol products
(bottles, cans, jars)
Non-aerosol products
(bags)
Aerosol products
Do not reuse container (bottle, can, jar).
Rinse thoroughly before discardina in trash.
Do not reuse bag. Discard bag in trash.
Replace cap and discard containers in
trash. Do not incinerate or puncture.

-------
                                                             (73)
                                                Appendix  IV-4
                                                (continued)
   2.  The labels foe all  other products  must  bear  container  disposal
       instructions,  based on container  type,  listed  below:
Container Type
Statement
Metal
containers
(non-aerosol)
Plastic containers
Glass containers
Fiber drums
with liners
Paper and
plastic bags
Compressea gas
cylinders
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or by
other procedures approved by state and local
authorities.
Triple rinse (or equivalent). Then offer
foe recycling or reconditioning, or puncture!
and dispose of in a sanitary landfill, or
incineration, or, if allowed by state and
local authorities, by burning. If burned,
stay out of smoke.
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved state and local procedures.
Completely empty liner by shaking and ,
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
reused^, dispose of in the same manner.
Completely empty bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning. If burned, stay
out of smoke .
Return empty cylinder for reuse (or
similar wording)
 i/ Manufacturer may replace this phrase  with  one  indicating
 ~~  whether and how fiber drum may be reused.

-------
                                                              (74)
                                                 Appendix  IV-4
                                                 (continued)


Pesticides that are hazardous wastes under 40 CFR 261.33(e) and  (f)
when discarded.

      "Acutely Hazardous" Commercial Pesticides (RCRA "E"  List)
                   Active Ingredients, (no inerts);

Acrolein
Aldicarb
Aldrin
Allyl alcohol
Aluminum phosphide
4-Aminopyridine
Arsenic acid
Arsenic pentoxide
Arsenic trioxide
Calcium cyanide
Carbon disulfide
p-Chloroaniline
Cyanides (soluble cyanide salts, not specified elsewere)
Cyanogen chloride
2-Cyclohexyl-4,6-dinitrophenol
Dieldrin
0,0-Diethyl S-[2-ethylthio)ethyl] phosphorodithioate
      (disulfoton, Di-Syston)
0,0-Diethyl 0-pyrazinyl phosphorothioate (Zinophos)
Dimethoate
0,0-Dimethyl 0-p-nitrophenyl phosphorothioate (methyl parathion)
4,6-Dinitro-o-cresol and salts
4,6-Dinitro-o-cyclohexylphenol
2,4 Dinitrophenol
Dinoseb
Endosulfan
Endothall
Endrin
Famphur
Fluoroacetamide •
Heptachlor
Hexanethyl tetraphosphate
Hydrocyanic acid
Hydrogen cyanide
Methorny1
alpha-Naphthylthiourea (ANTU)
Nicotine and salts
Octamethylpyrophosphoramide (OMPA, schradan)
Parathion

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                                                               (75)
                                                 Appendix  IV-4
                                                 (continued)
      "Acutely Hazardous" Commercial Pesticides  (RCRA  "E"  List)
                    Active Ingredients continued;

Phenylmercuric acetate (PMA)
Phorate
Potassium cyanide
Propacgyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacetate
Strychnine and salts
0,0,0,0-Tetraethyl dithiopyrophosphate   (sulfotepp)
Tetraethyl pyrophosphate
Thallium sulfate
Thiofanox
Toxaphene
Warfarin
Zinc phosphide

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                                                             C76)
                                                 Appendix IV-4
                                                 (continued)


        "Toxic" Commercial Pesticide Products (RCRA "F"  List)
                         Active Ingredients;

Acetone
Accylonitrile
Amitrole
Benzene
Bis(2-ethylhexyl)pthalate
Cacodylic acid
Carbon tetrachloride
Chloral (hydrate)
Chlordane (technical)
Chlorobenzene
4-Chloro-m-cresol
Chloroform
o-Chlorophenol
4-Chloro-o-toluidine hydrochloride
Creosote
Cresylic acid
Cyclohexane
Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta [c ,d] -pentalen-2-one
    (kepone, chlordecone)
1,2-Dibromo-3-chloiropropane (DBCP)
Dibutyl phthalate
S-3,3-(Dichloroallyl diisopropylthiocarbamate (diallate,  Avadex)
o-DiChlorobenzene
p-DiChlorobenzene
Dichlocodifluoromethane (Freon 12 )
3/5-Dichloro-N-(1,l-dimethyl-2-propynyl)  benzamide  (pronamide,Kerb)
Dichloro diphenyl dichloroethane (DDD)
Dichloro diphenyl trichloroethane (DDT)
Dichlocethyl ether
2,4-Dichlorophenoxyacetic, esters and salts  (2/4-0)
1f 2-Oichloropropane
1,3-Dichloropropane  (Telone)
Dimethyl phthalate
Ethyl acetate
Ethyl 4,4'-dichlorobenzilate (chlorobenzilate)
Ethylene dibromide (EDB)
Ethylene dichloride
Ethylene oxide
Formaldehyde
Furfural
Hexachlorobenzene
Hexachlorocyclopentadiene
Hexachloroethane
Hydrofluoric acid

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                                                             (77)
                                                 Appendix IV-4
                                                 (continued)

        "Toxic" Commercial Pesticide Products  (RCRA "F" List)
                         Active Ingredients;

Isobutyl alcohol
Lead acetate
Lindane
Naleic hydrazide
Mercury
Methyl alcohol
Methyl bromide
Methyl chloride
2,2'-Methylenebis (3,4,6-trichlorophenol)   (hexachlorophene)
Methylene chloride
Methyl ethyl ketone
4-Methyl-2-pentanone (methyl isobutyl ketone)
Naphthalene
Nitrobenzene
p-Nitrophenol
Pentachloroethane
Pentachloronitrobenzene  (PCNB)
Pentaclorophenol
Phenol
Phosphorodithioic acid, 0,0-diethyl, methyl ester
Propylene dichloride
Pyridine
Re soreino1
Safcole
Selenium disulfide
Silvex
1,2/4,5-Tetrachlorobenzene
1,1,2,2-Tetrachloroethane
Tetrachloroethylene
2,3,4 , 6-Tetrachlorophenol
Thiram
Toluene
1,1,1-Trichloroethane
Trichloroethylene
Trichloromonofluoromethane  (Freon 11 )
2,4,5-Trichlorophenol
2,4,6-Trichlorophenol
2,4,5-Trichlorophenoxyacetic acid  (2,4,5-T)
Xylene

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                                                          (78)
                                               Appendix IV-4
                                               (continued)
 'Toxic" Commercial  Pesticide  Products  (RCRA "F" List)
 Inert Ingredients;
Acetone
Acetonitrile
Acetophenone
Acrylic acid
Aniline
Benzene
Chlorobenzene
Chloroform
Cyclohexane
Cyclohexanone
Dichlocodifluocomethane  (Freon 12*)
Diethyl phthalate
Dimethylamine
Dimethyl phthalate
1,4-Dioxane
Ethylene oxide
Formaldehyde
Formic acid
Isobutyl alcohol
Meleic anhydride
Methyl alcohol (methanol)
Methyl ethyl ketone
Methyl methacrylate
Naphthalene
Saccharin and salts
Thiourea
Toluene
1,1,1-Tcichlocoethane
1,1,2-Trichloroethane
Tcichlorofluoromethane (Freon
Vinyl chloride
Xylene

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