&EPA
United States
Environmental Protection
Agency
Office of
Pesticides and Toxic Subrtanns
Washington DC 20460
August 1981
Coumaphos
0,0-diethyl 0-(3-chloro-4-methyl
-2-oxo-2H-1-benzopyran-7-yl)
phosphorothioate
Pesticide Registration
Standard
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Coumaphos
0,0-diethyl 0-(3-chloro-4-inethyl 2-oxo-2H-l-benzopryan-7-yl)
phosphorothioate
Pesticide Registration Standard
Elizabeth LaPointe
George Beusch
Hudson Boyd
Harry Craven
Mark Dow
Carolyn Gregorio
Curtis Laird
Lionel Richardson
William Schutte
Robert Storherr
Robert Zendzian
Owen Beeder
Lynn Brown
Tbnda Hicks
Gary Otakie
Joseph Panetta
Richard Johnson
Project Manager
Chemist
Environ, Chemist
Wildlife Bioloist
Entomologist
Tbxicologist
Wildlife Biologist
Environ. Chemist
Economist
Chemist
Pharmacolog ist
Project Manager
Project Manager
Secretary
Project Manager
Project Manager
Acting Section Head
June 30, 1981
Office of Pesticides and Toxic Substances
Environmental Protection Agency
401 M Street, SW
Washington, D.C. 20460
(SPRD)
(HED)
(HED)
(HED)
(BFSD)
(HED)
(HED)
(HED)
(BFSD)
(BFSD)
(HED)
(SPRD)
(SPRD)
(SPRD)
(SPRD)
(SPRD)
(SPRD)
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Coumaphos Registration Standard
Table of Contents
Chapter 1
bwtoRegisterUnderaReqistrationStandard ............. 1
Organization of the Standard 1
Purpose of the Standard . . . . . . . . . . . . . . . 1
Requirement to Reregister under the Standard 3
“PrcductSpecific”I) itaar3”Generic”E ta..... .......... 3
E ta Canpensation Requirements under FIFRA 3(c)(1)(D) 4
Cbtaining L ita to Fill “E ta Gaps”; FIFRA 3(c)(2)(B)..... 6
! mendments to the Standard • , • , , , , • • • , • • , • , • • • , 6
Chapter II Regulatory nsition . 8
Intrt* uction[[[ 8
t scription of chemical . . . . . . . . . . . . . . 8
Regulatorylksition/CoumaphosasSoleActive.................... 9
I q ulatory Rationale . . . . . . . . . . . . . . . . . . . . . . . . . . 9
Criteria For Registration Under the Standard...... . ..... . . . . .... 10
quired Labeling . . . . . . . . . . . . . . . . . . . . 14
¶1t)lerance Reassessment. . . . . . . * . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15
Chapter III Su nnary of 1 ta Requirements and t ta Gaps. ... . . .. 17
Chapter Iv Pro1uct Chemistry. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 50
‘l’echnical.... . .............e. .......... 50
Physica landchemicalProperties.............
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Chapter V E vironmenta1 Fate.. . 52
Use Profile...... .... ........... ... .... .. .. .. .......... ... .. . .. . 52
E ivironrnental Fate SuiuT ary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52
Ex xsure Profile . . . . . . . . . . . . . . . . . . . . . 52
Suninary of Major Data Gaps . 53
Chapter VI ‘ibxicology. . . . . . . . . • . . . * . . . 54
‘IbxicologySumnary- I chn icalODu1 aPhOS.............. 54
ute ‘I Dxicity 54
Subchronic ‘Itxicity . . . . . . . . . . . . . . . . 54
Chronic ‘I% xicity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 54
‘itxioo logySunmary—CoumaphosFormulations.....................55
‘Ibxicity hazard Assessment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 55
SuITrnar of Major 1 ta Gaps . . . . . . . . . . . 55
Chapter VII — Residue Ci emistry. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56
Residue Chemistry — ‘I chnical 56
Residue C emistry Profile . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56
Sunrnaz , of Major Data Gaps......... .... .... . . 57
Chapter VIII Ecological Effects. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58
Ecological Effects Suninary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 58
Sunuiary of Major i t.a Gaps . . . . . . . . . . . . . . 58
Chapter IX Efficacy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
Efficacy SI.1rriT ary. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59
Suninary of Major Data Gaps . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 60
....... .... ......................•. . 61
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I
now ‘10 REGISTER
UNDER A REGISTRATION STANDARD
Organization of the Standard
Purpose of the Standard
Requirement to Re—register Under the Standard
“Product Specific” Data and “Generic” Data
Data Canpensation Requirements under FIFRA 3(c) (1) (D)
Obtaining Data to Fill “Data Gaps”; FIFRA 3(c) (1) (D)
Amendments to the Standard
Organization of the Standard
This first chapter explains the purpose of a Registration Standard and
suiTrnarizes the legal principles involved in registering or reregistering under
a Standard. The second chapter sets forth the requirements that must be met to
obtain or retain registration for products covered by this particular
Registration Standard. In the remaining chapters the Agency reviews the
available data by scientific discipline, discusses the Agency’s concerns with
the identified potential hazards, and logically develops the conditions and
requirements that w uld reduce those hazards to acceptable levels.
Purpose of the Standard
Section 3 of the Federal Insecticide, Fungicide, and I denticide Act (FIFRA)
provides that “no person in any State may distribute, sell, offer for sale,
hold for sale, ship, deliver for shipoent, or receive (and having so received)
deliver or offer to deliver, to any person any pesticide which is not
registered with the Pdministrator [ of EPA) .“ TO approve the registration of a
pesticide, the Administrator must find, pursuant to Section 3(c)(5) that:
“(A) its cx position is such as to warrant the proposed claims for it;
(B) its labeling and other material required to be subaitted oanply
with the requirements of this Act;
(C) it will perform its intended function without unreasonable adverse
effects on the environment; and
(D) when used in accordance with widespread and caimonly recognized
practice it will not generally cause unreasonable adverse effects
on the environment.”
In making these findings, the Agency reviews a wide range of data which
registrants are required to subeit and assesses the risks and benefits
associated with the use of the proposed pesticide. But the established
approach to making these findings has been found to be defective on t counts:
First, EPA and its predecessor agency, the United States Department of
Agriculture (USDA), routinely reviewed registration applications on a “product
by product” basis, evaluating each product—specific application sanewhat
independently. In the review of products containing similar ocntponents, there
was little cç ortunity for retrospective review of the fu.U range of pertinent
data available in Agency files and in the public literature. Thus the “product
by product” approach was often inefficient and sanetimes resulted in
inconsistent or inocii lete regulatory judgnents.
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Second, over the years, as a result of inevitable and continuing advances in
scientific knowledge, methodology, and policy, the data base for many
pesticides came to be considered inadequate by current scientific and
regulatory standards. Given the long history of pesticide regulation in
several agencies, it is even likely that materials may have been lost fran the
data files. When EPA issued new requirements for registration in 1975 (40 CFR
162) and proposed new guidelines for hazard testing in 1978 (43 FR 29686, July
10, 1978 and 43 FR 37336, August 22, 1978), many products that had already been
registered for years were being sold and used without the same assurances of
human and environmental safety as was being required for new products. Because
of this inconsistency, Congress directed EPA to reregister all previously
registered products, so as to bring their registrations and their data bases
into canpliance with current requirements. (See FIEW Section 3(g)].
Facing the enormous job of re-reviewing and calling—in new data for the
approximately 35,000 current registrations, and realizing the inefficiencies of
the “product by product” approach, the Agency decided that a new, more
effective method of review was needed.
A new review procedure has been developed. Under it, EPA publishes documents
called Registration Standards, each of which discusses a particular pesticide
active ingredient. Each Registration Standard summarizes all the data
available to the Agency ai a particular active ingredient and its current uses,
and sets forth the Agency’s cC1T prehensive position on the conditions and
requirements for registration of all existing and future products which contain
that active ingredient. These conditions and requirements, all of which must
be met to obtain or retain full registration or reregistration under Section
3(c)(5) of FIFRA, include the sut*nission of needed scientific data which the
Agency does not now have, canpliance with standards of toxicity, cauposition,
labeling, and packaging, and satisfaction of the data canpensation provisions
of FIFRA Section 3(c)(l)(D).
The Standard will also serve as a tool for product classification. As part of
the registration of a pesticide product, EPA may classify each product for
“general use” or “restricted use” (FIFRA Section 3(d)]. A pesticide is
classified for “restricted use” when sane special regulatory restriction is
needed to ensure against unreasonable adverse effects to man or the
environment. Many such risks of unreasonable adverse effects can be lessened
if expressly-designed label precautions are strictly followed. Thus the
special regulatory restriction for a “restricted use” pesticide is usually a
requirement that it be applied only by, or under the supervision of, an
applicator who has been certified by the State or Federal government as being
canpetent to use pesticides safely, responsibly, and in accordance with label
directions. A restricted—use pesticide can have other regulatory restrictions
(40 CER 162.11(c) (5)] instead of, or in addition to, the certified applicator
requiremente These other regulatory restrictions may include such actions as
seasonal or regional limitations on use, or a requirement for the monitoring of
residue levels after use. A pesticide classified for “general use,” or not
classified at all, is available for use by any individual who is in xxnpliance
with State or local regulations. The Registration Standard review caupares
information about potential adverse effects of specific uses of the pesticide
with risk criteria listed in 40 CFR 162.11(c), and thereby determines whether a
product needs to be classified for “restricted use.” If the Standard does
classify a pesticide for “restricted use,” this determination is stated in the
second chapter. 2
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Requirement to Reregister Under the Standard
FIFRA Section 3(g), as amended in 1978, directs EPA to reregister all currently
registered products as expeditiously as possible. Congress also agreed that
reregistration should be acoanplished by the use of Registration Standards.
Each registrant of a currently registered product to which this Standard
applies, and who wishes to continue to sell or distribute his product in
canuerce, must apply for reregistration. His application must contain proposed
labeling that canplies with this Standard.
EPA will issue a notice of intent to cancel the registration of any currently
registered product to which this Standard applies if the registrant fails to
canply with the procedures for reregistration set forth in the Guidance Package
which accanpanies this Standard.
“ Product Specific” Data and “Generic” Data
In the course of developing this Standard, EPA has determined the types of data
needed for evaluation of the properties and effects of products to which the
Standard applies, in the disciplinary areas of Product Chemistry, Environmental
Fate, ‘Ibxicology, Residue Chemistry, and Ecological Effects. These
determinations are based primarily on the data Guidelines proposed in 1978 (43
FR 29696, July 10, 1978, and 43 FR 37336, ugust 22, 1978), as applied to the
use patterns of the products to which this Standard applies. Where it appeared
that data fran a normally applicable Guidelines requirement was actually
unnecessary to evaluate these products, the Standard indicates that the
requirement has been waived. Cn the other hand, in sane cases studies not
required by the Guidelines may be needed because of the particular ccttiposition
or use pattern of products the Standard covers; if so, the Standard explains
the Agency’s reasoning. Data guidelines have not yet been proposed for the
Residue Chemistry discipline, but the requirements for such data have been in
effect for sane time and are, the Agency believes, relatively familiar to
registrants. Data which we have found are needed to evaluate the
registrability of saiie products covered by the Standard may not be needed for
the evaluation of other products, depending upon the canposition, formulation
type, and intended uses of the product in question. The Standard states which
data requirements apply to which product categories. (See the third chapter.)
The various kinds of data normally required for registration of a pesticide
product can be divided into ts basic groups:
(A) data that are “ product specific, ” i.e., data that relate only to
the properties or effects of a product with a particular cc*nposition (or a
group of products with closely similar canposition); and
(B) “ generic ” data that pertain to the properties or effects of a
particular ingredient, and thus is relevant to an evaluation of the
risks and benefits of all products containing that ingredient (or all
such products having a certain use pattern), regardless of any such
product’ s unique ccnLposition.
The Agency requires certain “product specific” data for each product to
characterize the product’s particular ccmçosition and physical/chemical
properties (Product Chemistry), and to characterize the product’s acute
toxicity (which is a function of its total canposition). The applicant for
registration or reregistration of any p od t, whether it is a manufacturing—
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use or end—use product, arx I without regard to its intended use pattern, must
sutinit or cite enough of this kind of data to allow EPA to evaluate the
product. For such purposes, “product specific” data on any product other than
the applicant’ s is irrelevant, unless the other product is closely similar in
cx nposition to the applicant’s. (Where it has been found practicable to group
similar products for purposes of evaluating, with a single set of tests, all
products in the group, the Standard so indicates.) “Product specific” data on
the efficacy of particular end—use products is also required where the exact
formulation may affect efficacy and where failure of efficacy could cause
public health problems.
All other data needed to evaluate pesticide products concerns the properties or
effects of a particular ingredient of products (normally a pesticidally active
ingredient, but in sane cases a pesticidally inactive, or “inert”,
ingredient). Sane data in this “generic” category are required to evaluate the
properties and effects of all products containing that ingredient [ e.g., the
acute LD-50 of the active ingredient in its technical or purer grade; see
proposed 40 CFR 163.81—1(a), 43 FR 373551.
Other “generic” data are required to evaluate all products which both contain a
particular ingredient and are intended for certain uses (see, e.g., proposed
40 CFR l6382—l, 43 ER 37363, which requires subchronic oral testing of the
active ingredient with respect to certain use patterns only). Where a
particular data requirement is use—pattern dependent, it will apply to each end—
use product which is to be labeled for that use pattern (except where such end—
use product is formulated fran a registered manufacturing-use product
permitting such formulations) and to each manufacturing-Use product with
labeling that allows it to be used to make end-use products with that use
pattern. Thus, for example, a subchronic oral dosing study is needed to
evaluate the safety of any manufacturing—use product that legally could be used
to make an end—use, food-crop pesticide. But if an end—use product’ s label
specified it was for use only in ways that involved no food/feed exposure and
no repeated human exposure, the subchronic oral dosing study would not be
required to evaluate the product’s safety; and if a manufacturing—use product’s
label states that the product is for use only in making end-use products not
involving food/feed use or repeated human exposure, that subchronic oral study
would not be relevant to the evaluation of the manufacturing—use product either.
If a registrant of a currently registered manufacturing-use or end—use product
wishes to avoid the costs of data ainpensation [ under FIFRA Section 3(c) (1) (D)]
or data generation (under Section 3(c)(2)(B)] for “generic” data that is
required only with respect to sane use patterns, he may elect to delete those
use patterns fran his labeling at the time he reregisters his product. An
applicant for registration of a new product under this Standard may similarly
request approval for only certain use patterns.
I ta Compensation Requirements under FIFRA 3(c)(1)(D )
Under FIFRA Section 3(c) (1) (D), an applicant for registration, reregistration,
or amended registration must offer to pay cmpensation for certain existing
data the agency has used in developing the Registration Standard • The data for
which cxxnpensation must be offered are all data which are described by all of
the following criteria:
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(1) the data were first sulxnitted to EPA (or to its predecessor agencies,
USDA or F1Y ), on or after January 1, 1970;
(2) the data were sut:xnitted to. EPA (or USDT’t or FDA) by sane other
applicant or registrant in support of an application for an
experimental use permit, an amendment adding a new use to a
registration, or for reregistration, or to support or maintain an
existing registration;
(3) the data are relevant to the Agency’ s decision to register or
reregister the applicant’s product under the Peg istrat ion Standard,
taking into account the applicant’ s product ‘ s canposition and
intended use pattern(s);
(4) the data are determined by EPA to be valid and usable in reaching
regulatory conclusions; and
(5) the data are not those for which the applicant has been exempted by
FIFRA Section 3(c)(2)(D) fran the duty to offer to pay canpensation.
(This exemption applies to the “generic” data concerning the safety
of an active ingredient of the applicant’s product, not to “product
specific” data. The exemption is available only to applicants whose
product is labeled for end-uses for which the active ingredient in
question is present in the applicant’s product because of his use
of another registered product containing that active ingredient
which he purchases fran another producer.)
An applicant for reregistration of an already registered product under this
Standard, or for registration of a new product under this Standard, accordingly
must determine which of the data used by EPA in developing the Standard must be
the subject of an offer to pay caupensation, and must subeit with his
application the appropriate statements evidencing his canpliance with FIFRA
Section 3(c)(l)(D).
An applicant would never be required to offer to pay for “product specific”
data subnitted by another firm. In many, if not in n st cases, data which are
specific to another firm’s product will not suffice to allow EPA to evaluate
the applicant’s product; that is, will not be useful to the Agency in
determining whether the applicant’s product is registrable. There may be
cases, however, where because of close similarities between the ocxnpositiOn of
two or nore products, another firm’s data may suffice to allow EPA to evaluate
sane or all of the “product specific” aspects of the applicant’s product. In
such a case, the applicant may choose to cite that data instead of sukinitting
data fran tests on his own product, and if he chooses that option, he u1d
have to xmply with the Section 3(c) (1) (D) requirements with respect to each
item of “generic” data that relates to his product’s intended uses.
Each applicant for registration or reregistration of a manufacturing—use
product, and each applicant for registration or reregistration of an end—use
product, who is rot exempted by FIFRA Section 3(c)(2)(D), must cxxnply with the
Section 3(c) (1) (D) requirements with respect to each item of “generic” data
that relates to his product’ s intended uses.
A detailed description of the procedures an applicant must follow in applying
for reregistration (or new registration) under this Standard is found in the
Guidance Package for this Standard.
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Obtaining Data to Fill “Data Gaps”; FIFRA 3(c)(2)(B )
Sane of the kinds of data EPA needs for its evaluation of the properties and
effects of products to which this Standard applies have never been sub nitted to
the Agency (or, if st.±mitted, have been found to have deficiencies rendering
them inadequate for making registration decisions) and have not been located in
the published literature search that EPA conducted as part of preparing this
Standard. Such instances of missing but required data are referred to in the
Standard as “data gaps.”
FIFRA Section 3(c) (2) (B), added to FIFRA by the Congress in 1978, authorizes
EPA to require registrants to whan a data requirement applies to generate (or
otherwise produce) data to fill such “gaps” and sutinit those data to EPA. EPA
must allow a reasonably sufficient period for this to be accanplished. If a
registrant fails to take appropriate and timely steps to fill the data gaps
identified by a Section 3(c) (2) (B) order, his product’s registration may be
suspended until the data are sutinitted. A mechanism is provided whereby t or
more registrants may agree to share in the costs of producing data for which
they are both responsible.
The Standard lists, in the third chapter, the “generic” data gaps and notes the
classes of products to which these data gaps pertain. The Standard also points
out that to be registrable under the Standard, a product must be supported by
certain required “product specific” data. In sane cases, the Agency may
possess sufficient “product specific” data on one currently registered product,
but may lack such data on another. Only those Standards which apply to a very
small number of currently registered products will attempt to state
definitively the “product specific” data gaps on a “product—by-product” basis.
(Although the Standard will in sane cases note which data that EPA does possess
u1d suffice to satisfy certain “product specific” data requirements for a
category of products with closely similar canposition characteristics.)
As part of the process of reregistering currently registered products, EPA will
issue Section 3(c)(2)(B) directives requiring the registrants to take
appropriate steps to fill all identified data gaps -— whether the. data in
question are “product specific” or “generic” —- in accordance with a schedule.
Persons who wish to obtain registrations for new products under this Standard
will be required to sutiuiit (or cite) sufficient “product specific” data before
their applications are approved. Upon registration, they will be required
under Section 3(c) (2) (B) to take appropriate steps to suti it data needed to
fill “generic” data gaps. (We expect they will respond to this requirement by
entering into cost-sharing agreements with other registrants who previously
have been told they must furnish the data.) The Guidance Package for this
Standard details the steps that must be taken by registrants to ccinply with
Section 3(c)(2)(B).
Anendments to the Standard
Applications for registration which propose uses or formulations that are not
presently covered by the Standard, or which present product cciupositions,
product chemistry data, hazard data, toxicity levels, or labeling that do not
meet the requirements of the Standard, will autanatically be considered by the
Agency to be requests for amendments to the Standard. In response to such
applications, the Agency may request additional data to support the proposed
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amendment to the Standard, or may deny the application for registration on the
grounds that the proposed product v uld cause unreasonable adverse effects to
the environment. In the former case, when additional data have been
satisfactorily supplied, and providing that the data do not indicate the
potential for unreasonable adverse effects, the Agency will then amend the
Standard to cover the new registration.
Each Registration Standard is based upon all data and information available to
the Agency’s reviewers on a particular date prior to the publication date.
This “cut-off” date is stated at the beginning of the second chapter. ny
subsequent data sulmissions and any approved amendments will be incorporated
into the Registration Standard by means of addenda, which are available for
inspection at EPA in Washington, D.C., or copies of which may be requested fran
the Agency. When all the present “data gaps” have been filled and the
sutmitted data have been reviewed, the Agency will revise the Registration
Standard. Thereafter, when the Agency determines that the internally
maintained addenda have significantly altered the conditions for registration
under the Standard, the document will be updated and reissued for publication.
While the Registration Standard discusses only the uses and hazards of products
containing the designated active ingredient(s), the Agency is also concerned
with the potential hazards of sane inert ingredients and impurities.
Independent of the developnent of any one Standard, the Agency has initiated
the evaluation of sane inert pesticide ingredients. Where the Agency has
identified inert ingredients of concern in a specific product to which the
Standard applies, these ingredients will be pointed out in the Guidance Package.
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II
Regulatory Position
1. Introduction
This chapter describes the Z gency’s regulatory position on products which
contain coumaphos as the sole active ingredient. The ? 4 gency’s regulatory
position incorporates a number of considerations. Foren st anong these
considerations is an analysis of the registrability of products containing
coumaphos based on the risk criteria found in Section 162.11(a) of Title 40 of
the U.S. Code of Federal Regulations. The 1 gency’s determination is presented
below, and the rationale for this decision follows the position.
In addition to the basic regulatory decision and rationale, this chapter
includes the following: criteria for the registration of coumaphos products
under the Standard; acceptable ranges and limits for product canposition, acute
toxicity, and use pattern/application method; required labeling, and a
tolerance reassessment.
The scientific basis for decisions presented in this chapter can be found by
reading the various disciplinary chapters (Chapters IV-IX) which provide
sumaries of available scientific data on coumaphos. The data requirements and
data gaps are presented in Chapter III. Also, the rationale for requiring data
can be found in the footnotes of the tables in Chapter III. References to
) ency guidelines for testing are provided when appropriate. In instances
where the data requirements differ fra u the guideline requirements, the
rationale is presented in the footnotes of the tables.
2. I scription of Chemical
Coumaphos is an insecticide used to control flies, fly larvae, cattle grubs,
ticks, lice, fleas, , screwworms and fleeceworms on animals. The chemical
name for coumaphos is 0, O-d iethyl 0- ( 3-chloro-4-methyl--2-oxo-2H-1-benzopyran—7-
yl) phosphorothioate. For convenience in writing this Standard the name
“coumaphos” will be used instead of the chemical names • Use of the name
coumaphos, however, implies no endorsement of any product containing the active
ingredient. Coumaphos is the camon name accepted by the International
Organization of Standardization (ISO). The American National Standard
Institute has rot recognized coumaphos as the accepted camon name.
Trade names for counaphos include: Bay 21/199, Asuntol, Muscatox, Resitox,
Baymix®, Meldane, Unbethion, and Co-Ral®. (Co-Ral is the registered trademark
of the Farbenfabriken Bayer A.G. (MacI uga1l (19??) MRID 00005526). The
technical chemical names for coumaphos are:
a • 0, 0-diethyl 0—( 3—chloro -4-methyl—2-oxo-2H—1—benzopyran-7—yl)
phosphorothioate
b. 0- ( 3-chloro-4-methyl-7-counarinyl) 0, 0-diethyl phosphorothioate
c. 0,0-diethyl 0-(3—chloro-4--methyl-7-counarinyl) phosphorothioate
The Chemical Abstracts Registry (CAS) number for coumaphos is 56-72-4. The opp
(Shaughnessey) number is 036501. The nolecular formula is C 14 H 16 C10 5 PS.
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3. 1 gu1atory Iksition for Products Containing Coumaphos as the Sole Active
Ingredient
Coumaphos as described in this Standard may be registered for sale,
distributicri, formulation, arid use in the United States • Based on the review
of the limited data, the Agency, as of May 12, 1981, finds that none of the
risk criteria found in Section 162.11(a) of Title 40 of the U.S. Code of
Federal Regulations (CFR) were met or exceeded for cournaphos.
The Agency has considered the limited scientific data obtained frcni the open
literature as of May 12, 1981 and those data suheiitted by the registrants up
through the time of publication of this Standard. The Agency does not have
reason to believe that the use of this insecticide will cause unreasonable
adverse effects when used in canpliance with proper label directions and
precautions. Also, at this time, the Agency has no data with which to classify
existing counaphos products. Products will be classified when sufficient data
are available. Existing coumaphos products may be reregistered subject to the
conditions imposed fot data requirements. New coumaphos products may be
registered under this Standard, and are subject to the same requirements.
4. Regulatory Rationale
Counaphos was first registered as a pesticide in 1958. Current annual
production in the U.S. arrounts to approximately 500,000 lbs. It is used as an
insecticide on cattle, livestock, livestock bedding, sheep, goats, horses,
dogs, arid dog bedding, poultry, poultry housing and poultry litter. It is
applied as a dust, spray, dip, pour-on, and backrubber oiler. The products act
on the surface of arid systemically in the animal. Because the pesticide is
used to control certain public health pests on dogs (fleas, lice, arid ticks),
proof of the efficacy of counaphos for these uses is a registration requirement
(44 FR 27932: May 11, 1979).
Coumaphos is registered under §24(c) of FIFRA for use within the states of New
Mexico and California to meet special local needs. Five percent counaphos dust
bags are registered for control of scabies mite on desert bighorn sheep in NeW
Mexico. fle twenty-five percent wettable powder is registered for control of
scabies mite on cattle in California.
There are limited scientific studies available with which to assess the
registrability of all coumaphos products. Available acute toxicity data
indicate that: 1) a 50% wettable powder formulation is a severe eye irritant
and has a low acute dermal toxicity; and 2) that the oral toxicity of technical
counaphos is high. The data further indicate that a 25% wettable powder
formulation has an oral LD four times itore toxic than a 50% wettable powder
formulation. The one acce able chronic effects study denonstrates that
counaphos is not oncogenic in rats arid mice. Several studies suggest that
cournaphos is a cholinesterase inhibitor in animals although these studies do
not meet the Agency’s Guidelines for testing (see Chapter VI).
Residues of coumaphos are alequately analyzed in the literature and, as
discussed in section 7 of this chapter, do not exceed established U.S.
tolerances when the pesticide is applied according to label instructions (see
Chapter VIII). Sme data are ayailable on the physical/chemical properties of
technical coumaphos, but there are ma:jor gaps, particularly for the
manufacturing-use and end—use products (see Chapter IV). Qie study is
9
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available on ecological effects arid there are no data on the environmental fate
of oumaphos (see chapters V and VIII). The efficacy of the cxinpound ‘then used
on dcis is partially established in the literature; however, the gency accepts
the cxinpound as being efficacious on dogs based on the well—established
efficacy for livestock (see Chapter IX).
Although the data base is inccinplete, the ?iency has concluded that it should
continue the registration for this product for the following reasons:
-— No adverse effects have been discovered in the review of the available
studies on coumaphos which are not already adequately addressed by
FIFRA labeling requirements. Therefore, the benefits denonstrated by
the sale of this product outweigh the known risks.
-— The nine reported incidents under the Pesticide Incident Monitoring
System (PIMS) involving this chemical are poorly documented and do riot
establish that coumaphos, properly handled and applied, was the cause
of the adverse effects.
-— When coumaphos is applied according to label directions coumaphos
residues do not exceed the established U.S. tolerances.
-— The Standard protects against over—exposure to the pesticide in the
residential setting by requiring either child—resistant packaging or
veterinary use only for residential use products that n et the child
resistant packaging criteria.
-— The chemical is judged I y EPA to be efficacious in controlling fleas,
lice, arid ticks on dogs and dog bedding.
—— In accordance with FIFRA, the ? ency’ s policy is not to cancel
routinely the registration of products merely because of a lack
of data, or to withhold registration n rely because of lack of data.
(See Sections 3(c)(2)(B) and 3(c)(7) of FIFRA). Rather, publication
of the Standard provides a nechanism for identifying data needs and
the registration arid reregistration requirements. The Standard allows
for upgrading of labels during the period in which the required data
are being generated. When these data are received, they will be
reviewed by the Pt ency and the registrability of the chemical will be
reassessed.
5. Criteria for Registration Under the Standard
‘lb be subject to this Standard, oouiiaphos products must meet the following
conditions:
— contain coumaphos as the sole active ingredient;
-— be within acceptable standards of product canposition;
-— be within acceptable acute toxicity limits;
-— be labeled for acceptable end-uses;
-— bear required labeling.
10
-------
Technical and manufacturing—use coumaphos products must bear label directions
for formulation into acceptable end—uses.
The applicant for registration or reregistration of counaphos products subject
to this Standard must cxinply with all terms and conditions described in this
Standard, including cclTrnitment to fill data gaps on a time schedule specified
by the P ency and, when applicable, offer to pay oaapensation to the extent
required by Sections 3(c)(l)(D) and 3(c)(2)(D) of FIFBA, as amended, 7 U.S.C.
136(c) (1) (D) and 136 (c) (2) (D). As discussed in Chapter I, applicants for
registration under this Standard must contact the Pa ency for specific
instructions, including updated information on data requirements and ca panies
whose data can be cited and, in the event that these data are cited, to whem
canpensation must be offered.
A. Technical Coumaphos
1) Product Qx osition Standards
‘lb be covered under this Standard, the technical product may contain no less
than 90% coumaphos as the sole active ingredient. Any technical product
sutznitted for registration containing less than 90% coumaphos as the sole
active ingredient will be considered a new product and will not be req istrable
under this Standard.
2) Acute ‘ I xicity Limits
The P ency will consider registration of technical coumaphos products in the
following toxicity categories:
I II III IV
Acute Oral Toxicity yes yes yes yes
Acute Dermal Toxicity yes yes yes yes
Acute Inhalation Toxicity yes yes yes yes
Primary Eye Irritation yes yes yes yes
Primary Dermal Irritation yes yes yes yes
3) Use Patterns
To be covered under this Standard, technical coumaphos products must be labeled
for formulation into manufacturing—use products or for formulation into end-use
pesticides which are intended for insecticidal applications on animals, animal
housing, litter, and bedding.
B. Manufacturing-Use Counaphos
1) Product Caiposition Standards
To be covered under this Standard, manufacturing-use coumaphos must contain
coumaphos as the sole active ingredient. In addition, all manufacturing-use
coumaphos products must not contain impurities other than those in currently
11
-------
registered manufacturing—use products and at no higher concentration than those
in currently registered products. Any manufacturing—use product not meeting
these requirements will be considered a new product and will not be registrable
under this Standard.
Manufacturing-use products meeting these requirements may contain any
percentage active ingredient.
2) Acute ¶Lbxicity Limits
The kjency will consider registration of manufacturing—use coumaphos products
in the following categories:
I II III IV
Acute Oral xicity yes yes yes yes
Acute Dermal Dxicity yes yes yes yes
Acute Inhalation ‘Ibxicity yes yes yes yes
Primary Eye Irritation yes yes yes yes
Primary Dermal Irritation yes yes yes yes
3) Use Patterns
¶Ib be covered under this Standard, manufacturing-use cournaphos products must be
labeled for formulation into end—use pesticides which are intended for
insecticidal applications on animals, animal housing, litter, and bedding.
C. End-Use Cournaphos -- Dust, Wettable k 3er, Pressurized Spray, ur-on
Liquid, and E uulsifiable Concentrate
1) Product Canposition Standards
The following table shows the canposition standards end-use coumaphos products
must meet to be acceptable under this Standard. In addition, all end—use
counaphos products must not contain inerts and impurities other than those in
currently registered end—use products and at no higher concentration than those
in currently registered end-use products. Any end-use product not meeting
these requirements will be considered a new product and will not be registrable
under this Standard.
ForTrulation. Percent Active Ingredient
Dust (other than dog dust) up to 5%
Wettable Pow er up to 25%
Pressurized Liquids up to 3.5%
Ikur-on Liquid up to 4%
Dnulsifiable Concentrate up to 11.9%
12
-------
The only exception to the above ranges a ç1ies to products intended for control
of fleas, , and ticks on dogs and dog bedding. Such products must not fall
below 0.5% of the active ingredient for a dust, 1.0% for a pressurized liquid,
and 0.2% for a dip. ‘lb be registered for use on dogs, coumaphos products below
these concentrations will require the performance or citation of supportive
efficacy testing.
Inert ingredients in food—use formulations must be exempted fran the
requirement of a tolerance (or have tolerances established) under 40 CFR
180.1001. Currently, there are 17 inert ingredients used in coumaphos end—use
products that are not exempted under 40 CFR 180.1001(e). These 17 ingredients
are listed in the guidance package which acccxnpanies this Standard.
The gency has identified Freon, a chiorofluorocarbon, as an inert ingredient
in certain coumaphos products, fran review of current Confidential Statements
of Formula • The I gency has banned the use of chlorofluorocarbons in all but
critical pesticide products. The Pgency does not consider coumaphos a critical
product. Therefore, all products containing Freon are not registrable under
this Standard.
2) Acute Ibxicity Limits
The 1 ency will consider registration of any end-use coumaphos products for
danestic use in the following categories:
I II III IV
Acute Oral Tbxicity no no yes yes
Acute Derinal ‘Ibxicity no no yes yes
Acute Inhalation Thxicity no no yes yes
Primary Eye Irritation no no yes yes
Primary Dermal Irritation no yes yes
All coumaphos end-use products intended for danestic use as defined in 40 CFR
162.l6(b)(2) in ‘lbx Category III or IV, which meet the child resistant
packaging criteria (40 CFR 162.16), must either be packaged for child
resistance or be limited to and labeled for veterinary use only.
-------
The ? gency will consider registration of any end—use counaphos products for
nondanestic use with the following categories:
I II III IV
Acute Oral ¶t’ xicity no yes yes yes
Acute Derinal ‘Itxicity no yes yes yes
Acute Inhalation ¶L xicity no yes yes yes
Primary Eye Irritation no yes yes yes
Primary Dermal Irritation no yes yes yes
There are no currently registered end-use products in ‘I x Category I. Any
products sutinitted in this Category uld require supporting data, and uld
not be registrable under this Standard.
3) Use Patterns and Application Methods
¶Ib be registered under this Standard, end-use coumaphos products must be
labeled as insecticides for one or i ore of the following uses:
food use non-food uses
cattle dogs
goats dog bedding
swine livestock bedding
horses poultry housing
poultry poultry litter
sheep
be registered under this Standard, application rates of coumaphos products
must not exceed current levels. This interim restriction is necessary because
the data required to evaluate the environmental hazards of all coumaphos
products are inccrnplete. The Agency will reassess maximum application rates
of all uses when all data required have been sutmitted (see thapter III).
6. 1 quired Labeling
Al .]. coumaphos products must bear labeling as specified in 40 CER 162.10. The
guidance package for this Standard contains specific information regarding
label requirements.
14
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A. Technical and Manufacturing-Use Products
1) Use Pattern Statements
All technical and manufacturing—use products must list on the label the
intended end-use of formulated products produced fran the technical or
manufacturing—use products. In accordance with data to be suthUtted or cited,
all coumaphos technical and manufacturing-use product labels must bear the
following statements:
“For Formulation into an end-use product or an intermediate to
be formulated into an end-use product intended for
insecticidal use on animals, animal housing, litter, and
bedding. t ’
2) Precautionary Statements
Because of the absence of data needed to assess the environmental and health
hazards of counaphos, the I½gency cannot evaluate the adequacy of precautionary
statements on technical and manufacturing use product labels. Therefore, no
changes to current label statements are required at this time • The agency may,
after review of data to be su)initted under this Standard, require revisions to
current labels and may impose additional label requirements.
B. fl d-Use Coumaphos Products
Because of the absence of data needed to assess the environmental and health
hazards of cournaphos, the k ency cannot evaluate the adequacy of precautionary
statements on coumaphos end-use product labels. Therefore, no changes to
current label statements are required at this time. Registrants may, at their
option, label all &ettable pow3er formulations according to the requirements of
¶Lbxicity Category I for eye irritation and thereby be granted a waiver of the
requirement for further eye irritation testing (see Chapter III, ‘I ble C—2).
The Pt ency may, after review of all data to be subnitted under this Standard,
require revisions to current labels and may also impose a3ditional label
requirements.
7. Iblerance Reassessment
U. S. tolerances are established for residues of the insecticide coumaphos, 0,0—
diethyl 0- ( 3-chloro-4-nlethyl-2-oxo-2H-l-benzopyran-7-y1) phosphorothioate, and
its ox ’gen analog, 0 ,0-diethyl 0-3-chloro—4-niethyl-2-oxo--2H—l—benzopyran-7-yl-
phosphate, in or on raw agricultural products as follows: (40 CFR 180.189):
1 ppn in or on meat, fat, and meat by—products of cattle,
goats, hogs, horses, poultry, and sheep
0.5 p *n in milk fat (reflecting negligible residues in milk)
0.1 n in eggs.
15
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The tolerance established by the Canadian government is 0.5 ppii in meat . meat
by—products and fat of cattle, goats horsesr hogs, poultry, and sheep. This
is lower than the U.S. tolerance due to different methods of setting
tolerances. The Canadian tolerance reflects expected residues that are
statistically determined percentages of the maximum residues, rather than the
maximum residues used in setting U.S tolerances. ¶I mporary Codex Maximum
Residue P vels 1 ppu in poultry and fat of meat of cattle, 0.5 ppn in fat of
meat of sheep, pigs, goats, milk, and milk products, and 0.05 ppn in eggs are
proposed to be revoked due to a lack of supporting data.
The theoretical maximum residue contribution (ThRC) of total coumaphos in the
average ?nterican adult diet of milk, meat, fat, milk by—products, and eggs
containing the respective U.S. tolerance levels is calculated to be 0.22
mgjday/l.5 kg. CoLinaphos applied at the currently registered U.S. application
rates will r t exceed the established tolerances. Ebwever, the 1 ency is
unable to establish an acceptable daily intake (ADI) value for counaphos
because of the absence of acceptable sl ,se th1e_effect level” (NOEL) data.
The ? gency is, therefore, unable to assess the safety of current tolerances
because of the lack of chronic effects data. When the required chronic effects
data are sutinitted (see xicology data gaps in Chapter III) the Pgency will
assess the counaphos tolerances and revise them as necessary. In the meantime,
current U.S. tolerance levels will remain in effect.
16
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III.
Sumary of Data Requirements and Data Gaps
AEplicants for registration of coumaphos products must cite or subiiit the
information identified as required in the tables in this chapter. The tables
a p1icab1e to end—use products indicate whether the product to be tested is the
technical grade or a formulation.
The tables list the Proposed Guidelines which describe the type of data and
when the data are required to be su}xnitted [ 43 FR, No. 132, 29696 of July 10,
1978; and 43 FR, . 163, 37336 of August 22, 1978]. Justification for why the
test is required is pro iided in the Guidelines. A discussion of why data
additional to that already su}initted are necessary, or why data normally
required are not necessary for this chemical, are explained in footnotes to the
tables. The data requirements specified are the minimum that will be
required. Areas where additional data may be required as the result of tiered
testing are indicated.
‘7
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Thble Pr-i
Product thesistzy (See thapter IV)
c nerlc Data I quire ents
l4ust i Ei ai Data
&tiuitted urder FIFRA
? re Data D es EPA Have 3(c)(2) (Bfl If , maths
I quired Data to Partially a11 d for sutnission
G ide1ines ne of F This cx totally Satisfy Bibliogra )ic frott published date of
Citation Test Stardard? Q iipisition this I quirement? Citation — — Stardard .
163.61—3 Product Identity yes Technical grade partial 00005526 yes, 1 8 ma.
- flisciosure of active ingre—
of Ingredients dient (1 AI)
163.61—4 Dascription of yes IGAI 00005192, 00005526
manufacturing 05012747, 00005193
163.61—5 Discussion on IGAI yes 05003798, 00005838,
formation of 00005207, 00005435,
ziintentiona1 00005188, 00005189,
Ingredients
163.61—6 Daclaration sad as (See 163.61—5)
cartification
of ingredients
limits
163.61—7 Product analytical yes 00005433, 00005189 ro
mathods sal data 05003798, 00005278
05004290, 00005188,
00005187
163.61—8(1) a lcr 00005193, 00005307.
00005417, 00021981,
00005190, 00005526
163.61—8(2) o or yes (See 163.61—8(1))
163.61—8(3) Melting Point I yes (See 163.61—8(U)
July, 1981
-------
le A—i (Ccxit’d)
Product th nistry (See thapter IV)
Generic Data I quirei ents
— l4ist Pdditional Data be
Sthnitted under FI A
Are Data I es EPA Have 3(c)(2)(8)? If so, nonths
I quired Data to Partially allowed for sthnission
Qilde lines t ne of Fbr This or totally Satisfy Bib1iogra ic fran piilished date of
Citation st Standard? Cai ’osjtion this 1 quiresent? Citation — Standard .
163.61—8(4) Soithility yes ‘ibchnical graie pertial (See 163.61—8(1)) yes,-V 8 sos.
of active ingre-
dient (1 A1)
163.61—8(5) Stability !IGAI yes (See 163.61—8(1))
163.61—8(6) tasol/Water fl3A1 so (See 163.61—8(1)) yes, 8 sos.
pertition
cx,efficient
163.61—8(7) Physical State yes ! ICAI yes (See 163.61—8(1)) I0
163.61—8(8) Dansity or Specific yes 9XA1 so (See 163.61—8(1)) yes, 8 sos.
(kavity
163.61—8(9) alling Point yes I G A l (See 163.61—8(1)) so
163.61—8(10) V por Pressure yes ‘ I GAI (See 163.61—8(1)) so
163.61—8(11) *I yes !I GAI (See 163.61—8(1)) yes, 8 sos.
163.61—8(12) Storage Stability so
July, 1981
-------
Table A—i (Cait’d)
Product thenistry (See thapter I V)
Generic Data I quiren nts
______- Ibat Mditional Data be
Sthnitted under FIFRA
Are Data i ee A Have 3(c)(2)(B)? If so, iTOflthS
Icquired Data to Partially allowed for sd inission
Qaidelines t ne of br This ix totally Satisfy 8ibliograi ic fran piblished date of
Citaticn st Standard? Ca ositian this I c ilrenent? Citation 3/ — Standard .
163.61—8(13) Fl inability ro
163.61—8(14) idizinj cc
ucir Action
163.61—8(15) Dcplcsiveness
163.61—8(16) Miscibility no
163.61—8(17) Viscosity
Qaefficient
163.61—8(18) Q jusia
tharacteristics
163.61—9(19) DIelectric weak— no
* 1tage
163.61—9 oitta1 of no
sa p1es
July, 1981
-------
Footnotes
Table A—i
Product Chemistry
Generic Data Requirements
Coumaphos
1/ Certification that the ingredient statement accurately
reflects current production is required.
2/ A quantitative description of Solubility is required.
3/ The following studies were used in developing the
Standard. Although they are not cited in support of a
specific Guideline requirement, they were generally used:
05006145, 05010317, 05002073, 00005208, 00005528,
05002075, 00005336, 05002340, 05004089, 05005130,
05002360, 05004866, 00021997, 05014477, 05010318,
05003797, 00005298, 05003798.
21
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Table A—2
Environmental Fate (See thapter V)
Generic Data Requirements
Q tznaptcs
Mist Additional Data be
Sut*nitted under FIFRA
Are Data Daes EPA Have 3(c) (2) (B)? If so, months
Required Data to Partially allowed for suheission
Guidelines Nane of For This or totally Satisfy Bibliographic fran published date of
Citation Test Standard? Com sition this Requirement? Citation ___Standard.
163.62—7(b) Hydrolysis Radio—labeled no ” yes, 8 sos.
analytic grade
or technical
grade of active
ingredient
LAGf AI)
163.62—7(c) Photodegradation RLAG/ l AI no yes, 8 sos.
163.62—8(b) Aerobic Soil yes PL?tGfIGAI no yes, 26 sos.
Metabolime
163.62—8(c) Anaerobic Soil RLAG/1 3AI no yes, 26 sos.
Metabolime
163.62—8(d) Anaerobic Aquatic no
Metabolisn
163.62—8(e) Aerobic Aquatic no
Metabolisn
163.62—8(f) Microbial Metabo—
lime: 2
(1) Effects of reserved-’
Microbes on
Pesticides 2
(2) Effects of reserved—’
Pesticides on
Microbes
July, 1981
-------
Table A—2 (Cont’d)
thvirorinental Fate (See thapter Vi
Generic Data Requirenents
GeLinaphos
Itist ?dditional
.
Data
Are Data
Daes EPA Have
Sutznitted under FIFRA
3(c)
If
Requried
Data to Partially
(2) (B)?
so,
allowed for suhoission
Guidelines
Nene of
br This
or totally Satisfy
Bibliographic
fr an date of
Citation
Test
Standard?
Composition
this Requirement?
Citation
Standard.
163.62-8(g)
Activated Slixlge
reserved ’
-
reserved- ’
163.62-9(b)
Leaching
yes ’
Technical grade
of the active
ingredient (TGAI)
no
yes, 14 sos.
163.62—9(c)
Volatility
yes 1
i Ai
no
yes, 14 sos.
163.62—9(d)
so rpt ion!
Deso rpt ion
yes
IGAI
no
yes, 14 sos.
163.62—9 Ce)
ter Dispersal
yes
A representative
formulation type
no
yes, 14 sos.
163.62—10(b)
Terrestrial Field
Dissipation:
(1) Field & Vege—
table Crops
(2) Tree Fruit &
kit Crops Uses
(3) Pasture Land
Uses
(4) Damestic Out—
door Parks,
Ornanental &
Terf Uses
6’
reserved-’
6’
reserved—’
6’
reserved-’
no
no
no
no
July, 1981
-------
Table A—2 (Cont’d)
Environmental Fate (See thapter V)
Generic Data Requirenents
O3tJnaphos
ttist Additional Data be
Subnitted under FIFRA
Are Data
1 es EPA Have
3(c) (2) (B)? If so, uonths
Guidelines
Citation
Name of
Test
Required
Fbr This
Sthadard?
Composition
! ta to Partially
or totally Satisfy
this Requiresent?
Bibliographic
Citation
a11o ed for subsission
frun ptblished date of
Standard.
163.62—10(f)
combInation & Tank
Nix Field Dissipa-
tion
no
163.62—10(g)
tong Term Field
Dissipation Stndy
no
163.62—11(b)
Accunulation in
tational Crops
reserved ’
163.62—11(c)
Accunulation In
Irrigated Crops
no
163.62—11(d)
Fish A.cctznulation
yes
Radio—labeled
analytic grade or
technical grade
of the active
ingredient
no
yes, 14 sos.
163.62—11(e)
SpecIal Stndies
?ccunulation In
Aquatic Noncrop
no
163.62—13
Di sposal & Storage
reserved ’
Special
Qxnpssition and
ncentratIon in
feces
yes 2 ’
A representative
formulation — type
no
yes, 14 sos.
3uly, 1981
-------
Table A—2 (Cont’d)
Environmental Fate (See thapter V)
Generic Data Requirsnents
bua aphos
tist Additional Data be
Are Data
Daes EPA flave
Subnitted tmder FIFRA
Required
Data to Partially
3(c) (2) (B)? If so, months
Guidelines
Nane of
For This
or totally Satisfy
a11o d for subnission
Citation
Test
(5) Rights of Way,
elterbelts
& Related Uses
Standard?
no
Conposition
this Requirenent?
B1bliogra ic
Citation
fron p.tlished date of
Standard.
163.62—10(c)
Aquatic Field
Dissipation:
(1) Aquatic Food
Crop Uses
(2) Aquatic Non-
crop Uses
(3) Specialized
Aquatic Uses
no
no
no
no
.
163.62—10(d)
lèrrestrial/
Aquatic (Forest)
Field Dissipation
no
163.62—10(e)
Aquatic Impacts
Uses:
(1) Direct Dis—
charge
(2) Indirect
Discharge
(3) Waste ter
Treathent
no
no
no
July, 1981
-------
Footnotes
Table A-2
Environmental Fate
Generic Data Requirements
Coumaphos
1/ One hydrolysis study (MRID 05004309) was reviewed and
!ound scientifically invalid because of the lack of detailed
information concerning experimental conditions, including
temperature, darkness, and sterility of the samples. In
addition, discrepancies were found in the calculated data
dealing with levels of degraded coumaphos.
2/ The requirement for submission of these data is currently
‘being reserved pending the review and modification of the
testing protocols.
3/ The mobility of the test substance and its degradates in
soil shall be assessed either by soil thin layer chroma—
tography, soil column, or batch equilibrium (adsorptjon/de—
sorption) procedures. The use of coumaphos in dip vaps and
disposal of vat contents into the environment justifies this
data requirement, as well the use of dust bags (particularly
in feed lots).
4/ Laboratory volatility studies using nonradioisotopic
inalytical techniques are required to support the registration
of all formulated products intended for henhouse use, (to
which the greenhouse use referred to in l 63 .62—9(c) is
similar) and to evaluate reentry hazards from choljnesterase—
inhibiting pesticides, such as the health studies indicate
for coumaphos.
5/ This requirement will be met by data provided on leaching.
6/ Data may be required pending the outcome of special
studies of composition and concentration in feces.
7/ Data are required to show the maximum concentration of
Eoumaphos and its degradation products in chicken litter and
livestock manure at the time such materials are applied as
fertilizer.
26
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Table A—3
E o1ogical Effects (See thapter VI)
Generic Data i quirei ents
__________________ _____________ ________________________— Must 7 dditiona1 Data be
Sthnitted under FIFRA
Are Data i es EPA Have 3(c) (2) (B)? If so, mnths
quired Data to Partially al1 ed for sthnission
Qiidelines } T of Fbr This or totally Satisfy Bibliographic fran p&tlished date of
Citation ¶1 st Standard? O osition this E quira ent? Citation — Standard .
163.71—1 Avian Sirqle qredmical grale yes, 8 nos.
Dse a1 IC of the active
iogredient (!L AI)
163.71—2 Avian Dietary yes yes, 8 sos.
LCso
163 .71—3 ma1ian Acute ro
bxicity
163.71—4 A nan ! production
163.71—5 S inu1. & Actual ro
Field Tasting
for Matnials/Birds
July, 1981
-------
Teble A-3 (Contd)
1ogica1 Effects (See Chapter Vi)
Generic Data I quir i nts
?tzst h ditior r ta be
SthTtittel under FIFHA
Are Data tX,es EPA Have 3(c)(2 (B)? if so, ennths
i quired Data to partially allowed for sulittission
Guidelines of F This cx totally Satisfy Bibliographic ftun published date of
Citation ‘ jest Standard? Carqosition this i quirement? Citation Standard . — ____ —
163.72—1 Fish Acute LC Technical grnde ro yee, 8 n s.
of the active
ingredient
163.72—2 Acute ‘Ioxicity • 05009242 no
to Aqj.iatic
invertthrates
163.72-3 Acute xicity to
to Estuarine
Marine Dagani
163.72—4 B tryolarvae & no
Life-Cycle
163.72—5 k uatic Ckgan. no
lbX. & s1due
Stedies
163.72 —6 Simul. Actual
Field Testing for
?quatic Ct’ganlsns
July, 1981
-------
Table A—4
R)xi logy (See thapter VI)
Generic Data I quirements
- T ronar t &
&fnitted xder FIPPA
Are Data Xies EPA Have 3(c)(2)(B)? If , uonths
1 quirad Data to Partially alixxied for subuission
QJide linss t i of I This totally Satisfy Bibliographic tram p A ished date of
Citation Tast Standard? (lqx,sition this i guirenent? Citation Standard . ___________
163.81—1 .ite C a1 yes Ta nica1 grade yes 00005496
Ibxic ity of the active ( 0018-0O4
ir redient ( AI) 00J.8-O03
163.81—2 te Der al yes, 8 ecs.
‘mx lcity
163.81—3 ite Ithalation yes, 8 nos.
!lbxicity
163.81-4 Primary E yes 1r1AI yes, 8 nos.
irritation
163.81—5 Primary Deneal yes To yes, 8 ma.
irritation
163.81-6 Dermal ro yes, 8 me.
Sensitization
July, 1981
-------
Teble Pr-4 (Cont’d)
xicology (See thapter VI)
Generic Data 1 quiresont.s
Gu os
Must i idition r ta be
Sitinitted under FIFRA
Are Data rx es EPA Have 3(c)(2)(B)? If so, nonths
I quired Data to Partially allowed for aubnission
Guidelines te of br This cx totally Satisfy Bibliographic fran published date of
Citation Test Standard? Q iiçosition this 1 quir nent? Citation Standard. —
163.83-I thnnic Feeding yes Ted nical grede rio ’ yes, 50 sos.
of the active
th redient {1 AI)
163.83—2 Gucogenicity yes yes 05009938
163.83-3 Teratogenicity yes so yes, 26 sos.
163.83—4 ! pra3 x tion yes yes, 38 sos.
163.84—(2—4) Iltitagenicity yes yes, 26 rca.
163.85—1 Mutaboli n yes D thle-labeled partial 05004087 yes ”, 26 sos.
05012220
163.86—1 [ Xxnestlc
Animal Safety
Testing
July, 1981
-------
le A-4 ( nt’d)
! lbxicxilogy (See thapter VI)
Generic Data I quiresents
— - ?k2st iditiC4 al Data be
SLt2nitted ueder FIFRA
?tre Data IXes EPA Have 3(c)(2)(B)? If n nths
E (1iired Data to Partially allowed for suheission
Qaide lines iie of Fbr This ox totally Satisfy Bibliographic fra n published date of
Citation st Staedard? Cc.eç sition this tequirenient? Citation Star ard.
163.81—7 mute Delayed yesW 2’ d nical graie no yes, 14 nris
Neurotoxicity of the active
(j ,J thgredient (1 AI)
163.82-1 9bchronlc ka1 yes, 14 n s.
øxicity
163.82—2 Sti3thronic naY
(21-day) Deu a1
163.82-3 &.*thx ic 90— yes / I thnical grade yes. 14 nan.
day Deonal Toxicity of t1 active
iogredient
163.82—4 Sitchronic Leserved ’
Inhalation Toxicity
163.82—5 Sththronic reserved 2
urotoxicity
juIy, 1981
-------
Footnotes
Table A-4
Toxicology
Generic Data Requirements
Coumaphos
1/ Data are required on the technical chemical to provide
aThasis for comparison with the end—use product testing.
2/ Data are required because coumaphos is a cholinesterase
inhibitor.
3/ Two studies (MRID 00005384 & MRID 00005504) were reviewed
and found to be insufficient to meet the data requirements.
MRID 00005384 lacked histopathology and MRID 00005504 should
have been performed on weanling rats in order to determine
coumaphos’ toxicity during physical and sexual development.
4/ The subchronic 90—Day Dermal Toxicity Study (163.82—3)
is required instead.
5/ Data are required because coumaphos is used on dogs and
dog bedding and thus presents the potential for direct
application to human skin.
6/ Testing is required if results from acute inhalation
tests are positive.
7/ Testing is required if results from acute delayed
n urotoxicity tests are positive.
8/ One study (MRID 00005473) was reviewed and found
i adequate. The histopathology was inadequate with only 5
animals per dose being studied. No clinical studies were
performed.
9/ One study (MRID 00005148) was reviewed and found not to
meet the data requirements due to inadequate histopathology,
10/ Two studies (MRID 00004087 & MRID 05012220) provided
some information on the identity of major metabolites and
routes of elimination but no data are available to assess
the absorption of coumaphos as a function of dose and
duration of exposure. No information was provided on the
disposition of the leaving gr p. Te ing is required with
the double—labeled compound C P and C) to determine the
fate of the parent compound and leaving group.
32
-------
1 ble A—5
I eidue theslatry (See Ciiapter VII)
Generic Data juiresents
— i t iiticmal Data
Sitinitted urder FIFEA
Are Data Does E A iave 3(c) (2) (8)? If so, sonths
I quired Data to Partially a11 for aLtInission
Oiidelines Nsee of f c This or totally Satisfy 8ib1iogra )Ic fr a u pllisbed date of
Citation st Stardau ? fl-”çositicn this Paquirenent? Citatiau — Stardard . ______
ttho1i in so
plants
Metd)O11S in yea A representative See footnote /
Animals fr ” ’ticn type (P r)
a’
Analytical Methods yes See footiote—
residue Data: so
residue Data: so
residue Data: Milk yes 1 T See fotnote V
a d Meat ki D gs
Storage arvi Stability yes 00005190
July, 1981
-------
Footnotes
Table A-5
Residue Chemistry
Generic Data Requirements
Co umapho s
1/ 05004087,
— 05004483,
05100522,
00005454,
00005401,
05008968,
00005323,
05003806,
00005450
05003806, 05012748,
00005332, 00005392,
2/ 05004066,
— 00005438,
05006630,
00005308,
00005080,
00005437
00005328, 00005342, 00005289,
00005509, 05004211, 05017521,
3/ 00005293,
— 00005338,
05004690,
00005333,
00005396,
00005479,
00005831,
00005834,
00005235,
00005040,
00005456,
00005451,
00005161,
00005329,
00005186,
00005509,
00005830,
00005395,
00005822,
00005483,
00005214,
00005082,
00005042,
00005453,
05010354,
00005400,
05006630,
00005056,
00005080,
00005510,
00005511,
00005047,
00005485,
05010096,
00005074,
00005492,
00005448,
00005480,
00005456,
00005295,
00005493,
00005336,
05005830,
00005339,
05005125,
00005832,
00005491,
00005490,
00005441,
05004066,
00005840,
00005458
00005331,
05012915,
00005081,
00005051,
00005399,
00005048,
00005833,
00005317,
00005486,
00005437,
00005440,
00005842,
4/ The following studies were used in developing the
Standard. Although they are not cited in support of a
specific Guideline requirement, they were generally used:
05002359, 05016099, 00005439, 0500???? Knapp, 05004087,
00005402, 05108561, 05003799, 05006806.
34
-------
Table B—i
Product-Chemistry (See Chapter IV)
Product—Specific Data Requirements for Manufacturing—Use Products
CounaFE os
Mist Mditional Data be
Sukinitted i.nder ‘I A
Are Data
Des EPA Have
3(c) (2) (B)? If so, scnths
Required
Data to Partially
allowed for suheission
Guidelines
Name of
For This
or totally Satisfy
Bib1iogra tiic
from published date of
Citation
Test
Standard?
Composition
this Requirement?
Citation
Standard.
163.61—3
Product Identity
and disclosure
of Ingredients
yes
Each product
no
yes, 8 sonthe
163.61—4
DescrIption of
inanufactur 1mg
process
yes
Each product
no
yes, 26 mnths
163.61—5
Discussion on
formation of
w intentIonal
ingredients
yes
Each product
no
yes, 26 sonths
163.61-6
Declaration and
certification
of ingredients
limits
yes
Each product
no
yes, 8 nonths
163.61-7
Product alytica1
methods and data
yes
Each product
no
yes, 8 nonths
163.61—8(1)
Color
no
163.61—8(2)
C)3or
no
163.61—8(3)
Melting Point
no
( ,1
U,
July, 1981
-------
Table B—i (Cont’d)
Product- hemistr (See thapter IV)
Product Specific Data Requirements for Manufacturing—Use Products
CoLinaphos
f tist Mditional Data be
Subuitted under FIFRA
Are Data D es EPA Have 3(c) (2) (B)? If so, months
Required Data to Partially allowed for subnission
Guidelines Name of Fbr This or totally Satisfy Bibliographic frau pttlished date of
Citation Test Standard? Composition this Requirement? Citation Standard.
163.61—8(4) Sol ±ility no
163.61—8 (5) Stability no
163.61—8(6) tenol/Water no
partition
coefficient
163.61—8(7) Vhysical State yes Each product yes, 8 sos.
163.61—8(8) Demeity or Specific yes Each product yes, 8 ens.
Gravity
163.61—8(9) Boiling Point no
163.61—8(10) vapor Pressure
163.61—8(11) Each product yes, 8 sos.
163.61—8(12) Storage Stability yes Each product no yes, 8 sos.
July, 1981
( J
0%
-------
Table B—i (Cont’d)
Product-O anistry (See thapter IV)
Product-Specific Data Requirenents for Manufacturing—Use Products
a—
Guidelines
Citation
Nene of
Are Data
Required
Pbr This
Standard?
Co s osition
Daes EPA Have
Data to Partially
or totally Satisfy
this Requiranent?
.
BibliograçMc
Citation
tist I’dditional Data be
Subnitted uider FIFRA
3(c) (2) (B)? If on, nontha
allowed for st ission
fran pi iished date of
Standard.
163.61-8 (13)
Fl ir ability
yesr ’
Each product
no
yes, 8 sos.
163.61—8(14)
Cbcidizing or
Reducing Action
yes ’
Each product
no
yes, 8 sos.
163.61—8(15)
Explosiveness
yes ’
Each product
no
yes, 8 sos.
163.61—8(16)
Miscibility
yes ”
Each product
no
yes, 8 sos.
163.61-8(17)
Viscosity
Coefficient
yesW
Each prod*x t
no
yes, 8 sos.
163.61—8(18)
Q,rrosion
tharacteristics
yes
Each product
no
yes, 8 sos.
163.61-9(19)
Dielectric Break—
down Voltage
no
163.61—9
$.tznittal of
s 1es
no
July, 1981
( 4
-------
Footnotes
Table B—i
Product Chemistry
Product—Specific Chemistry Data Requirements for
Manufacturing—Use Products
Coumaphos
1/ For each product containing a volatile, flammable
ing red lent.
2/ For each product containing an oxidizing or reducing
agent as an Ingredient.
3/ For each product containing a potentially explosive
ingredient.
4/ For emulsifiable products which may be diluted with
petroleum solvents.
5/ For liquid formulations.
38
-------
Table 8—2
lbxicoloqy (See Qiapter VI)
Product-Specific Data Requiresents for Manufacturing—Use Products
Counaphos
I vst Additional Data be
Suh*nitted under FIFRP
Are Data Daes EPA Have 3(c) (2)(B)? If so, months
Required Data to Partially allowed for subuission
Guidelines Name of For This or totally Satisfy Bibliographic fran Published date of
Citation - _ Fest Standard?— - Com sition this Requiresent? Citation Standard.
163.81-1 ?cute Oral no
lbxicity
163.81—2 ?cute Dermal no
Th3cicity
163.81—3 Acute Inhalation no
Thzicity
163.81—4 Primary Eye
Irritation
163.81—5 Primary Dermal no
Irritation
163.81-6 Dermal no
Sensitization
July, 1981
/ Data are required on tI m technical product for extrapolation to the manufacturing—use prcd t.
‘0
-------
Table 8—2 (Cont’d)
Toxiooloqy (See thapter VI)
Product—Specific Data Requiresents for Manufacturing-Use Products
LIna i os
Dees EPA Have
Data to Partially
or totally Satisfy
this Requirenent?
Z4ist Pdditional Data be
Subnitted under FIFRA
3(c)(2)(B)? If so, months
al1o d for subnission
fran pitlished date of
163.81—7 Pcute Delayed
Neurotoxicity
163.82—1 ibchronic Oral
Thxicity
163.82—2 & bchronic
(21-day) Dermal
163.82—3 Subchronic 90—
day Derinal ‘rbxicity
163.82—4 Subcbronic
Inhalation lbxicity
163.82—5 &ibthroriic
Neurotoxicity
Guidelines
Citation
Nsne of
Test
Are Data
Required
For This
no
no
no
no
Bibliographic
Citation
/ Data ar. required on the technical product for ectrapolation to the manufacturing—use product.
cD
July, 1981
-------
Table 5—2 (Cont’d)
Toxico1c gy (See thapter VI)
Product—Specific Data Requirenents for Manufacturing—Use Products
O,unaphos
Mist Mditiona]. Data be
Sutinitted der FIFRA
Are Data Daes EPA Have 3(c) (2) (B)? If so, nonths
Required Data to Partially allo d for subeission
Guidelinee N e of For This 1 or totally Satisfy Bibliogra Mc fron pLtlished date of
Citation Test Standard ? 1 Coeçosition this Requirenent? _ _ citaticn Standard . _______
163.83—1 thronic Feeding no
163.83-2 cogenicity no
163.83—3 ratogenicity no
163.83—4 Reproduction no
163.84— (2-4) Jeitagenicity no
163.85—1 Metabol lse
163.86—1 Disnestic no
Animal Safety
Thsting
July, 1981
/ Data are required on the ted nica1 themical for ectrapolation to the manufacturing—t e product.
-------
Table C—i
Product—chemistry (See thapter IV)
Product-Specific Data Requirements for End—Use Products
O Lznaphos
r4.ist Additional Data be
Sutinitted mder FIFRA
Are Data Daes EPA Have 3(c) (2)(B)? If no, nonths
Required Data to Partially allowed for subnission
Guidelines Name of FOr This or totally Satisfy Bibliogra ic from published date of
Citation Test Standard? Composition this RequiraTlent? — Citation Standard. —
163.61—3 Product Identity yes Each product no yes, 8 nontha
and disclosure
of Ingredients
163.61-4 DescrIption of Each product yes, 26 months
manufacturing
process
163.61—5 Discussion on yes Each product yes, 26 months
formation of
ucintentional
ingredients
163.61-6 Declaration and yes Each product yes, 8 months
certification
of ingredients
limits
163.61—7 Product analyttcal yes Each product no yes, 8 months
moth,ds and data
163.61—8(1) O,lor yes Each product no yes, 8 months
163.61—8(2) Q3or yes Each product no yes, 8 months
163.61—8(3) Melting Point no
July, 1981
-------
Table C—i (Cont’d)
Product-Chemistry (See Chapter IV)
Product—Specific Data Requirements for End—Use Products
cotmiaphos
Guidelines
Citation
N&ne of
Test
Are Data
Required
For This
Standard?
Composition
Does EPA Have
Data to Partially
or totally Satisfy
this Requirement?
Bibliographic
Citation
&ist dditional Data be
Subeitted under FIFRA
3(c) (2) (B)? If so, sonths
allowed for subuission
from published date of
Standard.
163.61—8(4)
Solubility
no
163.61—8(5)
Stability
to
163.61—8 (6)
Octano ljWater
partition
coefficient
no
163.61—8(7)
Thysical State
yes
Each product
no
yes, 8 sonths
163.61—8(8)
Density or Specific
Gravity
yes
Each product
no
yes, 8 nonths
163.61—8(9)
BoilIng Point
no
163.61—8(10)
Vapor Pressure
no
163.61—8(11)
I
yes
Each product
no
yeS, 8 ixonths
163.61-8(12)
Storage Stability
yes
Each product
no
yes, 8 nonths
July, 1981
(‘4
-------
Table C—i (Cont’d)
Product-Chemistry (See Chapter IV)
Product-Specific Data Requirements for Fn&-Use Products
cbtinaphos
ist Mditional Data be
Subnitted u der FIFRA
7 re Data
Ibes EPA Have
3(c) (2) (B)? If so, nonths
N ne of
Test
Required Data to Partially
For This or totally Satisfy
Standard? Canposition this Requirement?
Bibliogra lc
Citation
allowed for s hnission
fron p tlished date of
Standard.
Guidelines
Citation
163.61—8 (13)
163.61—8(14)
163.61—8(15)
163.61—8(16)
163.61—8(17)
163.61—8(18)
163.61—9(19)
163.61—9
Fl ability
yes 4 ’
Each
product
no
yes, 8 sos.
Cbcidizing or
Reducing Action
yes ”
Each
product
yes, 8 sos.
E cp1oáiveness
yee ’
Each
product
no
yes, B sos.
Miscibility
yes
Each
product
no
yes, 8 sos.
Viscosity
Chef ficient
yesW
Each
product
yes, 8 sos.
corrosion
Characteristics
Each
product
yes, 8 sos.
Dielectric Break—
do m Voltage
no
ibnitta1 of
s tip1es
July, 1981
.
-------
Footnotes
Table C—i
Product Chemistry
Product—Specific Chemistry Data Requirements for
End—Use Products
Coumaphos
1/ For each product containing a volatile, flammable
ingredient.
2/ For each product containing an oxidizing or reducing
agent as an ingredient.
3/ For each product containing a potentially explosive
ingredient.
4/ For emulsifiable products which may be diluted with
petroleum solvents.
5/ For liquid formulations.
45
-------
Table C—2
Toxicology (See thapter VI)
Product—Specific Data Requirements for End—Use Products
Counaphos
P ist ?dditiona]. Data be
Subnitted under FIFRA
Are Data Daes EPA Have 3(c) (2) (B)? If so, sonths
Required Data to Partially allowed for sithuissiori
Guidelines N ne of For this or totally Satisfy Bibliographic fran published date of
Citation Test Standard? Composition this Requirement? Citation Standard.
163.81—1 ? ute Oral yes Each product yes 00005416 yes, 8 sos.
Thxicity
163.81—2 Pcute Dermal yes Each prcduct 4 ’ no yes, 8 sos.
Ibxicity
163.81—3 Acute Inhalation yes ’ Each product ’ yes, 8 sos.
¶bxicity
163.81—4 Primary Eye yes ’ Each product no yes, 8 sos.
Irritation
163.81—5 Primary Dermal yes Each productL’ yes, 8 sos.
Irritation
163.81—6 rma1 Sensitization yes Each productV yes, B sos.
July, 1981
-------
Footnotes
Table C-2
Toxicology
Product—Specific Date Requirements for End—Use Products
Coumaphos
1/ The Agency has the option of combining end-use products
Tnto groups of “substantially similar” products and requiring
testing on only one product in the groups. Groups are made
up of end—use products of similar concentrations and for-
mulation type. This reduces the testing burden imposed on
the registrant. In the case of coumaphos, however, available
toxicity data show that products may not necessarily be
rationally grouped by conventional means.
Acute oral toxicity studies with technical coumaphos have
demonstrated that the toxicity of the compound varies with
the physical form of the chemical and the vehicle in which
the oral administration is made (Hecht 1958, GS0018003).
Studies have also shown that a 25% wettable powder for-
mulation is four times more toxic than a 50% wettable powder
formulation (Lamb and Anderson, 1974, MRID 00005416, Hecht,
1958, GS0018003). The Agency would be willing to consider
combining coumaphos end—use formulations into groups of
substantially similar products if the above anomalies in the
oral toxicity data can be explained. Otherwise, testing is
required on each coumaphos end—use formulation.
2/ Testing is required if products are found to produce a
respirable vapor, or if 20% more of the aerodynamic equivalent
is composed of particles not larger than 10 microns.
3/ One study (MRID 00005414) has shown that a 50% wettable
pOwder formulation causes eye irritation and corneal damage
in rabbits at 21 days, placing the formulation in Toxicity
Category I. The Agency will waive primary eye irritation
testing for other coumaphos wettable powder formulations if
registrants agree to place Toxicity Category I precautionery
statements on the end—use product labels.
47
-------
1 ble C—3
Efficacy (See thapter IX)
Predt t—S ecific Data 1 quireientS for E) i-Use Products
________ _________ — Must Mditional Data
Sthnitted uoder FIFRA
Are Data Daes EPA Have 3(c) (2) (B)? If , nonths
Haquired Data to partially alIO%&d for sulrznission
Site of F This cx totally Satisfy Bibliographic fran pu b1ished date of
Citation - Pest Starsiard? Cbrçosition this I quires nt? Citation — Starriarth — - —
I s fleas yes 0.5% txlst 00005344 I V )
00005326, 00005211
1.0% Pressurized yes 00005087 1O
Liqui i
lice 0.5% D
1.0% PrL yes 00005098 IV )
ticks 0.5% I) yes ( 00l8—00l 10
1.0% PrL yes 00005087
I j bedding fleas 0.5% 0 yes ( 0018—00l IV)
1.0% PrL yes 00005087 10
Co
lice 0.5% D no
1.0% PrL 00005088 10
ticks 0.5% D CS0018—001 I X )
1.0% PrL 00005087 to
July, 1981
-------
Footnotes
Tables C-3
Efficacy
Product—Specific Data Requirements for End—Use Products
Coumaphos
1/ Efficacy of the .5% dust formulation for control of lice
on dogs and dog bedding is assumed due to extrapolation from
efficacy studies done on lice infesting larger agricultural
animals and their bedding (MRID 00005352, 05011422, 00005028,
00005033, 00005200).
49
-------
Iv
Product Chemistry
Product Chemistry SunTnary - cbnica1 Coumaphos
ODumaphos is synthesized by reacting diethyl phosphorothi 8 nochloridate with 3-
chioro 4 n ethyl-7 hydroxycoiunarin (chiorferron) at 50-100 C and atmospheric
pressure, in the presence of a suitable solvent, and acid—binding agent and
finely divided copper as a catalyst. After the reaction the mixture is cooled,
filtered, the product is recovered by evaporating the solvent (Sittig Manual
(1977) r ise Data Crop. Park Ridge! N.J.). In addition confidential data
describing the coumaphos manufacturing process have been review by the 1 ency
(MRID 00005192). The nolecular structure of counaphos is:
CHfCH 2 O\ o_ç’ r”° ‘ c=o
CH 3 —CHj—O
CH
The Agency has reviewed the available information on ultraviolet
spectrophotometric n thods (MRID 05004290, 00005188, 00005187) and found them
adequate for the identification and quantitation of coumaphos in the technical,
manufacturing-use, and end-use products. Methods are also available for the
analysis of certain impurities (MRID 00005433, 00005189, 05003798, 00005278).
There are 17 inert ingredients used in counaphos end-use products that are not
cleared for use on animals under 40 CFR 180.1001(e). 1 gistrants of end-use
products with inert ingredients that have not been cleared must either remove
the ingredient fran the product or obtain clearance from the 1 gency. The
1v ency has found one inert ingredient, Freon, a chiorofluorocarbon, to be
unacceptable for use in end—use pesticide products because of its potential to
deplete the ozone layer of the atmosphere (see 43 CFR 11318).
Physical and Chemical Properties
Some data are available on the physical and chemical properties of axznaphos.
D which are not available but which are required to be sutxnitted are listed
in the tables in Chapter III. Available data on technical coumaphos are as
follows:
Color , tan
( or : weak but not unpleasant
Me ltinjPz)int : 90 92 0 C
So1ubili y insoluble in water, soluble in aromatic solvents, less
soluble in alcohols and ketones.
Stabi1i : stable under normal use conditions, hydrolyzes slowly under
alkaline conditions.
50
-------
Physical State : crystalline solid
Boiling I int : 20°C at a prox. 1 x l0 nm Hg
Vapor Pressure : 1 x IO urn Hg at 20°C
The above physical and chemical properties for technical coumaphos were
reported under MRID 00005193, 00005307, 00005417, 00021981, 00005190, 00005526.
Sunmary of Major Data Gaps
The major data gaps for this chemical are: clarification of ingredient
statements, solubility in quantitative anounts, octanol/water partition
coefficient, density or specific gravity, pH for the technical product,*
certain physical and chemical properties for manufacturing—use and end-use
coumaphos products and certain product chemistry data on end-use products.
* Depending on solubility in water, which is not known in quantitative terms.
51
-------
V.
Environmental Fate
Use Profile
Couriaphos is an insecticide registered for use on livestock and livestock
bedding, poultry, poultry housing, poultry litter, dogs, arid dog bedding.
Q-ie technical coumaphos product and three manufacturing—use products are
registered. Counaphos is formulated into end-use products as a dust, wettable
powder, pressurized liquid, emulsifiable concentrate, ready—to-use pour—on,
ready—to—use spray, spray foam, spray concentrate and backrubber oiler. The
registration of a new flowable product is pending. Some coumaphos products are
applied topically and act to control external pests; others are applied
topically but act systemically to control internal parasites. Coumaphos
products are sanetimes applied to livestock using dust bags or dip vats • There
are several other registered application methods and numerous registered
concentrations.
Approximately 500,000 lbs. of couinaphos are produced in the United States
annually. Approximately 60% is formulated into emulsifiable concentrates and
wettable powders, 36% into dusts, 2% into ready—to-use solutions, and 1% into
pressurized liquids. Beef cattle account for 87% of coumaphos use arid dairy
cattle account for 12%; emulsifiable concentrates and wettable powders are the
primary formulations used on cattle. Use on other livestock, poultry, and dogs
account for the remaining 1% of coumaphos use.
Environmental Fate Surrmery
There is one scientifically valid study on the environmental fate of
coumaphos. Coumaphos (purity unspecified) applied at 2 and 100 ppu inhibited
the respiration of Azotobacter vinelandii , a nitrogen—fixing bacterium, by 50%
and 33% respectively (MacRae and Celo 1974, MRID 05005579). The authors did
not address the apparent contradiction that higher concentrations result in
lower respiratory inhibition. t’ k conclusions about the environmental fate of
coumaphos can be drawn fran this study.
Exposure Profile
Because of the absence of data on the exposure arid environmental fate of
couflaphos, it is not possible to quantitatively assess exposure of humans and
wildlife to coumaphos. Mixers and applicators of coumaphos formulations are at
risk of the highest direct exposures. Dermal arid eye exposure can result f ran
splashing during the diluting, mixing, and use of emulsifiable concentrates and
wettable powders. Respiratory exposure could occur fran “puff back” during
handling of dusts and wettable powders. The potential for respiratory exposure
after application cannot be assessed due to the lack of vapor pressure data.
52
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The general public and daTlestic animals are exposed to t xui iaphos because it is
registered for use a dogs and dog bedding. The use of cournaphos on meat and
dairy livestock and poultry also results in dietary exposure to the general
public; see Chapter VII, r sidue Chemistry, for a discussion of dietary
exposure to counaphos. The use of counaphos-contaminated poultry litter and
manure as fertilizer on field and vegetable crops, tree fruit and nut crops,
and pasture land, presents the potential for human dietary and non—dietary
exposure. This potential was not evaluated due to the lack of data.
Suinnary of Major Data Gaps
The major data gaps for this chemical are hydrolysis, soil metabolism,
leaching, volatility, adsorption/desorption, water dispersal, fish
accumulation, photodegradat ion, and canposition and concentration in feces.
53
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VI
Toxicology
Toxicology Sunmary - Technical Coumaphos
Acute Toxicity
Studies have shown that technical coumaphos has a very high acute oral toxicity
and is classified as Toxicology Category 1. Acute oral toxicities in rats have
been reported ranging fran 17.1 to 87.0 mg/kg depending on sex, physical form
of the chemical, and the method of adfninistration used (Narcisse 1976, MRID
00005496, Johnston and Scott 1965, GSOO18—004, F cht 1958, ( 00l8—003).
Subchronic Toxicity
Inadequate studies assessing the subchronic toxicity report a no-observable—
effect level (NOEL) equal to or less than 2 pu in the diet of adult nongrel
dogs and adult Sprague Dawley rats. In the dogs RBC cholinesterase activity
was depressed 35% when coumaphos was administered in the diet at 50 ppii for 12
weeks. Serum cholinesterase activity was depressed 18% at 2 ppi , 42% at 5 prrn,
59% at 10 ppn, and 68% at 50 ppii over the same 12 week period. Activity
returned to rx)rmal in 3 weeks. I b clinical signs of toxicity were reported
(Vaughn, et. al. 1958, MRID 00005384). The dog study does not satisfy the data
requirements because the histopathology was inadequate. In the rats RBC
cholinesterase activity was depressed at 40 pn after 8 and 16 weeks. Serum
cholinesterase activity was depressed in females at 2, 5, and 20 p n at 8 and
16 weeks and in males at 10 çpn at 8 weeks. (Vaughn, et al. 1958, MRID
00005504). The rat study should have been performed on weanling rats to
determine the toxicity of couTlaphos during physical and sexual develorment and
therefore does not meet data requirements.
Chronic Toxicity
An acceptable oncogenicity study reported no observed carcinogenic effect fran
coumaphos fed at 10 ppn and 20 ppn for ts years in the diet of rats and mice
(NCI 1979, MRID 05009938).
An inadequate chronic feeding study in rats (Doull, et al. 1960, MRID
00005473) reported a NOEL of 5 wn in the diet. Depression of cholinesterase
activity was reported at 10 p n and higher dose levels in serum erythrocytes
and sutinaxillary glands. At 25 and 100 ppn there was increased nortality and
at 100 p ui fasciculations and infrequent cxnvulsions were reported. The
histopathology was inadequate because only S animals per dose were studied and
no clinical studies were performed. The study therefore does not meet the data
requirements.
An inadequate 3 generation nouse reproductive effects study reported a NOEL of
10 ppli. bb effects on reproduction were observed which cx)uld not be attributed
to maternal toxicity (Doull, et. al. 1962, MRID 0005148). Die to the
inadequate histopathology the study does not meet the data requirements.
54
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Data on the metabolism of oo aphos are incanpiete. Four phosphorous-
containing metabolities were identified (diethyl phosporothioic acid,
phosphoric acid, diethyl phosphoric acid, and de—ethylated derivative of
coumaphos) but their time and dose relationship was not quantified. The
disposition of the canpiex leaving group was not followed (Krueger, et al.
1959, MRID 05004087, Vickery, MRID 0512220).
‘ Ibxicology Suimiary -— Coumaphos Formulations
One study is available on a 50% wettable po ier (WP) formulation which reports
an acute LD 5 for male rats of 363 mg/kg (Lamb and Anderson, 1974, MRID
00005416). A second study using a 25% wettable power formulation reported an
acute LD of 22.5 mg/kg in male rats and 13.5 mg/kg in female rats (Hecht,
1958, G9Cftil8003). Further testing is required to resolve the apparent
contradication in the data, particularly because the 25% WP formulation is
reported to be as toxic as sane technical material.
An acceptable study shows that a 50% WI ’ formulation has an acute dermal LD
of greater than 2 mg/kg placing the formulation in ‘Ibxicity Category III ( mb
and Anderson 1974, MRID 00005416). An acceptable eye irritation study on a 50%
WI’ formulation showed irritation and corneal damage to persist after 21 days
placing the formulation in ‘D3xicity Category I for eye irritation (Lamb and
Matzkanin 1975, MRID 00005415).
lbxicity Hazard Assessment
Technical coumaphos has a very high acute oral toxicity. carcinogenic
effect has been report d. The 50% WP has been shown to have a very low acute
dermal toxicity but to cause severe eye irritation.
Sunmary of Major Data Gaps
The major data gaps for this chemical are nost of the acute studies on the
technical chemical and end—use products, and, subchronic oral toxicity,
subchronic 90 day dermal toxicity, chronic feeding, teratogenicity,
reproductive effects, mutagencity, and metabolism on the technical chemical.
testing is required on the manufacturing—use products because the testing
required on the technical will be used to support the registrability of the
manufacturing—use product.
55
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VII
Residue Chemistry
Residue Chernis try - Thchnical Cournaphos
Residue Chemistry Profile
Coumaphos is an organophosphorus insecticide applied to animals topically in
the form of dusts, sprays, dips, and pour—ons. The dusts and liquid
formulations act topically as ll as systemically to control certain insects
and parasites. The systemic products control internal parasites by the
absorption of the active ingredient through the skin (ruminants, non-ruminants,
and poultry).
The metabolism of coumaphos in animals is adequately defined by the available
data. The primary residue of concern is oDumaphos par se and its oxygen
analog. (MRtD 05004087, 00005454, 00005323, 05003806, 05012748, 05004483,
00005401, 05003806, 00005332, 00005392, 05100522, 05008968, 00005450).
The metaboli of counaphos in plants is not of concern because coumaphos is
not applied to crops.
Three different analytical procedures have been developed for the detection of
coumaphos residues and all have been evaluated in EPA laboratories and found
acceptable for the collection of residue data and enforcement of established
tolerances. The procedures are 1) spectrofluorophotanetry, 2) gas-i iquid
chrcinatography, and a ircdified photofluoranetric method (MRID 05004066,
000005308, 00005328, 00005342, 00005289, 00005438, 00005080, 00005509,
05004211, 05017521, 05006630, 00005437).
The available residue data are adequate to support existing tolerances. They
include data for coumaphos and its metabolite. These data are cited in Table
A— 4 under “Residue Data; Milk, Meat and E#ggs”.
Studies conducted with both non-labeled and 32 p-labeled counaphos show that
when animals and poultry are treated with couTtaphos according to label
recaiinendations, there will be no residues in eggs, milk, meat, fat and neat by-
products in excess of the established tolerances. (See Table A-4, “Residue
Data; Milk, Meat and Fags”).
U.S. tolerances are adequately supported by residue data for coumaphos, 0,0-
d iethyi. 0- ( 3-chloro-4-methyi-2-oxo-211-i-benzopyran-7-yi ) phosphorothioate and
its oxygen analog, 0, 0-diethyl 0— (3 -chloro-4-rnethyl-2-oxo-2H—l—benzopyran-7-yl)
phosphate, j.n or on raw agricultural products. These tolerances (40 CFR
180.189) are as follows:
1 p xn — in or on meat, fat and meat by-products of cattle,
goats, hogs, horses, poultry, and sheep.
0.5 pçzn — in milk fat (reflecting negligible residues in milk).
0.1 ppn — in eggs.
56
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Based on the tolerances, the theoretical maximi.in residue contribution (‘ITvIRC) of
total coumaphos is calculated to be 0.22 mg/day/i 5 kg (unverified printout of
Acceptable Daily Intake, 40 CFR 180.189, cxumaphos, February 9, 1981.) This
figure is based on the average adult eating pattern and on the assumption that
milk, meat, fat, meat by-products, and eggs contain residues hith meet the
respective tolerance levels.
T mporary Codex Maximum Residue Levels are 1 pps in poultry and fat of cattle,
0.5 in in fat of sheep, pigs, goats, milk and milk products, and 0.05 çzi in
eggs. The P ency is unable to assess the adequacy of the Codex tolerances due
to a lack of supporting data.
Suirinary of Major Data Gaps
There are r data gaps in Residue Chemistry.
57
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VIII.
Ecological Effects
Ecological Effects Surrmary
There is one acceptable study on the ecological effects of coumaphos. It shows
the 96 hour LC for technical cxurnaphos administered to mature scuds
( GanTnarus Lasc tus ) to be .15 ugh (Sanders 1972, MRID 05017538). This
study does not meet the Agency’ s Guidelines for testing because iinnature
animals were not used; however, the study is acceptable because it shows that
coumaphos is very highly toxic to aquatic invertebrates. There are no
acceptable studies on the effects of coumaphos on plants or non—target insects.
Surm ary of Major I ta Gaps
The data gaps for this chemical are the avian single-dose LD , the avj&i
dietary LC , the fish acute LC 50 , and an acute toxicity to uatic
invertebra s.
58
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Ix
Efficacy
Efficacy Suirmary
The review of coumaphos data is limited to efficacy data only as they relate to
public health applications. The Agency has provided for the waiver of efficacy
data suhirtission as part of the registration process in all other instances (44
FR 17932; May 11, 1979).
The public health applications of cou-naphos are limited to the pesticide’s use
to control fleas, lice, and ticks on dogs and dog bedding.
Products registered for use on dogs and dog bedding and covered by this
Standart are a 0.5% dust and a 1% pressurized liquid. The pressurized liquid
product that is .25% counaphos and 0.5% trichlorfon (0,0—Dimethyl 2,2,2—
trichloro—l-hydroxyethy]. phosphonate) is a double—active ingredient product and
is therefore not registrable under this Standard.
Available data indicate that counaphos in various formulations and at a
concentration as low as 0.2% is effective in achieving sane degree of control
of fleas, lice, and ticks on dogs (MRID GS0018002, 00005087, 00005200,
00005326, 00005344, 00005088, 00005211).
Available data also indicate that a 0.5% coumaphos dust formulation controls
fleas and ticks on dog bedding, (MRID GSOO I800I). An in vitro laboratory
study showed that counaphos ranging in concentration fran .05% to 3.2% is
effective against ult fleas ( Xenopsylla cheopis) , effectiveness reaching
100% at the 0.4% concentration, Courilaphos was sanewhat less effective in
controlling larvae of X. cheopis ; 100% control was reached at the 3.2%
concentration (MRID 05007632).
There appear to be several factors which may influence the efficacy of
coumaphos. Sane of these factors are: animal hair coat (length and type),
method of application, species or type of pest, and arrount of active material
applied. Stuart (1959, GSOO18001) noted problems in obtaining control of
fleas when hair coat was thick and matted. Genung (GS0018002) presents data
which seems to indicate nore rapid control of ticks following application by
washing as opposed to counaphos applied as a dust. Stuart and Brewster (MRID
00005086) observed greater ease in controlling fleas as opposed to obtaining
similar control of ticks. Stuart (GSOOI800 I) observed “light dusting” of
young pups did not result in as rapid or cauplete control as a heavier dusting
applied to a:lult animals.
59
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Suim ary of Major Data Gaps
The data deficiencies for aximaphos are related to the efficacy of the 0.5%
dust in controlling lice on dogs and dog bedding. There are st ies which
indicate that the 0.5% dust and the 1% dust are effective against lice
infesting several species of agricultural animals and their bedding. Sane
exemplary studies are &itith and Richards, 1955, (MRID 00005352), Knapp, 1962,
(MRID 05011422), Bayvet, 1971, (MRID 00005028), Minter, 1970, (MRID 00005033),
and Kohier, 1967, (MRID 00005200). By extrapolation fran the large animal
studies, the 1 gency assumes that the 0.5% dust is effective in controlling lice
on dogs and dog bedding and thus the absence of data does riot constitute a data
gap.
60
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Guide to Use of This Bibliography
1. Content of Bibliography . This bibliography contains citations of all the
studies reviewed by EPA in arriving at the positions and conclusions
stated elsewhere in this Standard. The bibliography is divided into 4
sections: (1) citations that contributed information useful to the review
of the chemical and considered to be part of the data base supporting
registrations under the standard -— this section is cross—referenced by
numerical identifiers, for easy access to studies cited in the Standard;
(2) citations examined and judged to be inappropriate for use in developing
the Standard; (3) standard reference material; and (4) potentially useful
studies identified too late in the process of developing the standard to be
considered. The fourth section cites the studies identified by the basic
producer as being absent frau the cxinputerized search of the literature.
The studies were identified too late to be given a formal review. This
section also includes a single citation for a group of studies subaitted in
support of a flowable coumaphos product. Any of the studies in Section
Four that, upon review, fill data gaps, will then be considered as
amendments to the Guidance Package. Primary sources for studies in this
bibliography have been the body of data su nitted to EPA and its
predecessor agencies in support of past regulatory decisions, and the
published technical literature.
2. Units of Entry . The unit of entry in this bibliography is called a
“study”. In the case of published materials, this corresponds closely to
an article. In the case of unpublished materials sukriitted to the agency,
we have sought to identify documents at a level parallel to a published
article fran within the typically larger volumes in which they were
sukinitted. The resulting “studies” generally have a distinct title (or at
least a single subject), can stand alone for purposes of review, and can be
described with a conventional bibliographic citation. We have attempted
also to unite basic documents and ccnnentaries upon them, treating them as
a single study.
3. Identification of Entries . The entries in this bibliography are sorted
by author, date of the document, and title. Each entry bears, to the left
of the citation, an eight-digit numeric identifier. This number is unique
to the citations, and should be used at any time specific reference is
required. This number is called the “Master Record Identifier”, or
“MRID”. It is r t related to the six-digit “Accession Number”, which has
been used to identify volumes of sul:iuuitted data; see paragraph 4(d)(4)
below for a further explanation. In a few cases, entries added to the
bibliography late in the review may be preceded by a nine-character
temporary identifier. This is also to be used whenever a specific
reference is needed.
61
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4. Form of the Entry . In addition to the Master Record Identifier (MRID),
each entry consists of a bibliographic citation containing standard
elements followed, in the case of materials suhi’iitted to EPA, by a
description of the earliest known sutinission. The bibliographic
conventions used reflect the standards of the American National Standards
Institute (ANSI), expanded to provide for certain special needs. Sane
explanatory notes of specific elements follow:
a. Author . Whenever we could confidently identify one, we have chosen
to show a personal author. When no individual was identified, we
have shown an identifiable laboratory or testing facility as author.
As a last resort, we have shown the first known submitter as author.
b. tkcuIr nt Date . When the date appears as four digits with no
question marks, we took it directly fran the document. When a four-
digit date is followed by a question mark, the bibliographer deduced
the date fran evidence in the document. When the date appears as
(19??), we were unable to determine or estimate the date of the
document.
c. Title . This is the third element in the citation. In sane cases it
has been necessary for our bibliographers to create or enhance a
document title. Any such editorial insertions are contained between
square brackets.
d. Trailing Parentheses . For studies suhsnitted to us in the past, the
trailing parenthese include (in addition to any self-explanatory
text) the following elements describing the earliest known submission:
(1) Submission Date . IlTunediately following the rd
“received” appears the date of the earliest known
submission.
(2) Administrative Number . The next element, iim ediately
following the word “under,” is the registration number,
experimental permit number, petition number, or other
administrative number associated with the earliest known
submission.
(3) Submitter . The third element is the submitter, following
the phrase “submitted by”. When authorship is defaulted to
the submitter, this element is anitted.
62
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(4) Volurr Identification . The final element in the trailing
parenthesis identifies the EPA accession number of the
volume in which the original suliiiuission of the study
appears. The six-digit accession number follows the symbol
“CDL,” standing for “Company t ta Library.” This accession
number is in turn followed by an alphabetic suffix which
shows the relative position of the study within the volume.
For example, within accession number 123456, the first study
would be 123456—A; the second, 123456—B; the 26th, 123456—Z;
and the 27th, 123456—AA.
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Coumaphos
Section One:
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
(References Listed by MRtD Numbers)
MRID Citation
00005028 Bayvet (1971)
00005033 Minter, R.W. (1970)
00005034 Huggins, K.G. (1970)
00005040 Olson, T.J. (1971)
00005042 Chemagro Corporation (1971)
00005047 Chemagro Corporation (1967)
00005048 C1 iemagro Corporation (1967)
00005051 Cheinagro Corporation (1968)
00005056 Chemagro Corporation (1963)
00005074 Anderson, C.A. (1959)
00005080 Chemagro Corporation (1969)
00005081 Chemagro Corporation (1969)
00005082 Irx ustria1 Bio—Test Laboratories (1974)
00005087 Stuart, W.R. (1960)
00005088 Bayvet (1961)
00005148 DDu1I, J., R,ot, M., and Cowan, J. (1962)
00005161 Anderson, C.A. (1959)
00005186 Bayvet (19??)
00005187 Chemagro Corporation (1962)
00005188 Chemagro Corporation (1962)
00005189 Chemagro Corporation (1962)
00005190 Young, J.W. (1962)
00005192 Costello, J.R. (19??)
00005193 Chemagro Corporation (1957)
00005195 Anderson, C.A. (1958)
00005200 Kohier, P.11. (1967)
00005207 Bayvet (1967)
00005208 Bayvet (1965)
00005210 Bayvet (1964?)
00005211 Skaptason, J.S., MacI) uga1l, D. (1960)
00005214 Chemagro Corporation (1964)
00005235 Cheinagro Corporation (1964)
00005278 Waskeski, D.M. (1953?)
00005289 Mains, j. (1964)
00005293 themagro Corporation (1966)
00005295 Chemagro Corporation (1966)
00005307 nose, W.B.; White, C.E. (1971)
00005308 Mobay Chemical Corporation (1964)
00005317 Cheinagro Corporation (1964)
00005326 Williams, G.M. (1959)
00005328 Mams, J.M. (1961)
00005329 chemagro Corporation (1963)
00005331 themagro Corporation (1961?)
00005332 Kruegar, H.R.; Casida, JE.; Niedermeier, R.P. (1961)
00005333 chemagro Corporation (1960)
00005336 chemagro corporation (1964?)
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Office of Pesticide Programs
Registration Standard Bibliography
Case (350018 Cournaphos
Section One:
Citations Considered to be Part of the Data Base
Suççorting Registration Under the Standard
(References Listed by MRID Numbers)
MRID Citation
00005338 Chernagro Corporation (1966)
00005339 Chemagro Corporation (1967)
00005342 darns, J.M. (1963)
00005344 Skaptason, J.S. (1959)
00005345 Cheinagro Corporation (1966)
00005352 itith, C.L., Richards, R. (1955)
00005384 Vaoughn, G., E ininger, E., and Ebull, J.. (1958a)
00005392 Cheinagro Corporation (1959)
00005395 k e1man, D. (1958)
00005396 Gronberg, R.R. (1958)
00005399 Gronberg, R.R. (1958)
00005400 Anderson, C.A. (1959)
00005401 Radeleff, R.D.; Claborn, W.V. (19577)
00005402 Bobbins, W.E.; Fbpkins, T.L.; Darrow, D.I.; E}idy, G.W.
(1959)
00005415 Lamb, D.W., and Matzkanin, C.S. (1975)
00005416 Lamb, D.W., and £4atzkanin, C.S. (1975)
00005417 Bayvet (1974)
00005433 Caswell, R.L. (1962)
00005435 Cheinagro Corporation (1966)
00005437 Chemagro Corporation (1968)
00005438 Thornton, J.S. (1968)
00005439 Chemagro Corporation (1968)
00005440 Chemagro Corporation (1960?)
00005441 Chemagro Corporation (1961)
00005448 Anderson, C.A. (1959)
00005450 Iburrough, H.W.; Brady, O.E., Jr.; Tinmei:man, J.A.;
Arthur, B.W. (1959)
00005451 Anderson, C.A. (1959)
00005453 Anderson, C.A. (1959)
00005454 Eburrough, H.W.; Brady, U.E., Jr.; Tirnmerman, J.A.;
Arthur, B.W (1959)
00005456 Chemagro Corporation (1960)
00005473 Ebull, J,, Vesselinovitch, D., Fitch, R., Boot, M., and
Meskauskas, J. (1960)
00005479 Gronberg, R.R. (1958)
00005480 Chemagro Corporation (1960)
00005483 Chemagro Corporation (1959?)
00005485 Chemagro Corporation (1962)
00005486 Chemagro Corporation (1962)
00005490 Ditinan, L.?. (1963)
00005491 Chemagro Corporation (1963)
00005492 Chemagro Corporation (1961)
00005493 Chemagro Corporation (1961)
00005496 Narcisse, J.K. (1967)
00005504 Vaughn, G., Deininger, E. and r)Dull, J. (1958b)
65
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Coumaphos
Section One:
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
(References Listed by MRID Numbers)
MRID Citation
00005509 Bayvet (1968)
00005510 Chemagro Corporation (1968)
00005511 Chemagro Corporation (1969)
00005526 Mactxxigall, D. (19??)
00005528 Bloom, D. (1969)
00005822 Chemagro Corporation (1963)
00005830 Chemagro Corporation (1964)
00005831 Chernagro Corporation (1964)
00005832 Chemagro Corporation (1964)
00005833 Chemagro Corporation (1964)
00005834 Cheinagro Corporation (1964)
00005837 Chemagro Corporation (1961)
00005838 Chemagro Corporation (1961)
00005840 Chemagro Corporation (1960)
00005842 Chemagro Corporation (1960)
00021981 Chemagro Corporation (1964)
00021997 Mobay Chemical Corporation (1966)
050????? Knapp, F.W. (1962)
05002073 Barney, J.E. II (1965)
05002075 Braithwaite, D.P. (1963)
05002340 t mico, J.N. (1966)
05002359 Askew, J.; Ruzicka, J.H.; Wheals, B.B. (1969)
05002360 Keith, L.H.; Alford, A.L. (1969)
05003797 Volpe, Y.; Mallet, Y.N. (1976)
05003798 Waskeski, D.M. (1966)
05003799 Zakrevsky, J.G.: Mallet, V.N. (1975)
05003806 Radeleff, R.D.: Claborn, H.V. (1960)
05004066 Anderson, C.A.: 1 ams, J.M.: McDzugall, D. (1959)
05004087 Krueger, H.R.; Casida, J.E.; Neidermeier, R.P. (1959)
05004089 E1—Refai, A.; 1bpkins, T.L. (1965)
05004211 Bo uan, M.C.; Beroza, M. (1967)
05004290 Kane, P.F.; Cohen, C. J.; Betker, W..R.; MacD3ugall, D. (1960)
05004395 Keith, L.H.; Garrison, A.W., Alford, A.L. (1968)
05004690 Flurwood, I.S. (1966)
05004483 Kaplanis, J.N.; Ibpkins, D.E.; Treiber, G.H. (1959)
05004866 McKinley, W.P.; Read, S.I. (1962)
05005125 Burnett, E.M. (1970)
05005130 Hartmen, C.H. (1966)
05005579 MacRae, IC; Celo, J.S. (1974)
05005830 Matthysse, J.G.; Lisk, D. (1968)
05006145 Ackermann, H. (1969)
05006630 Oehler, D.D.; Eschle, J.L.; Miller, JA.; Claborn, H.V.;
Ivey, M.C., (1969)
05006806 Zwieg, G., ed.; Sherma, J., ed. (1972)
05007632 Fox, I., et al. (1966)
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Coumaphos
Section One:
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
(References Listed by MRtD Numbers)
MRID Citation
05008968 D3rough, H.W.; Brady, U.E., Jr.; Tinmerman, L.A.;
Arthur, B.W. (1961)
05009242 Sanders, 11.0. (1969)
05009938 National Cancer Institute (NCI) (1979)
05010096 Bo man, M.C., et a]. (1968)
05010317 Babad, H,; Herbert, W.; Goldberg, M.C. (1968)
05010318 1 ss, R.T.; Biros, F.J. (1970)
05100522 DDrough, 11W.; Brady, U.E., Jr. Tininerman, J.A.;
Arthur, B.W. (1961)
05012220 Vickery, D.S., and Arthur, B.W. (1960)
05012747 Kasin v, D.D. (1969)
05012748 Kasirr v, D.D. (1969)
05012915 FL O working Party of E cperts on Pesticide Residues (1973)
05013242 Ebrough, H.W.; Brady, U.E., Jr.; TirriTterman, J.A.;
Arthur, B.W. (1961)
05014477 Pflugmacher, J.; Ebing, W. (1978)
05016099 Beroza, M.; Bownan, M.C. (1971)
05017521 McLeod, H.A.; Butterfield, A.G.; Lewis, D.; Phillips,
W.E.J.; Coffin, D.E. (1975)
05017538 Sanders, H .0. (1972)
05108561 Thornburg, W. (1971)
GSOO18001 Stuart, W. (1959)
GS0018002 Genung, W. (1959)
GS0018003 Hecht, G. (1958)
GS0018004 John ton, C.D., and Scott, W.J. (1965)
67
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO I8 Coumaphos
Section One:
Citations Considered to be Part of the L ta Base
Supporting Registration Under the Standard
Product Chemistry
MRID Citation
05006145 Ackerrnann, H. (1969) Duennshichtchromatographisch—enZymatischer
Nachweis phosphororganishcer Insektizige: zum
duennschichtechrcraatgraphischen Verhal ten einiger s iterer
Insektizide— Thin—layer chranatographic—enzyrnatic determination
of organophosphorus insecticides: thin-layer chrc atographic
behaviour of sa further insecticides. Journal of Chrar atgraphy
44(2) :414—418.
05010317 Babad, H,; Herbert, W.; (bldberg, M.C. (1968) Nuclear magnetic
resonance studies of phosphorus (V) pesticides: Part I —
Chemical Shifts of protons as a means of identification of
pesticides. Aualytica Chimica Acta 41(2):259—268.
05002073 Barney, J.E. II (1965) New spray tests for detecting
organophosphorus canpounds on thin—layer chranatograms. Journal
of Chrctnatography 20(2):334—341.
00005208 Bayvet (1965) Confidential Ingredient Statement: Co—Ral 1% Ready—To—
Use Spray. (Unpublished Study received June 4, 1965 under 11556—
16; CDL:126968—D).
00005207 Bayvet (1967) Confidential Ingredient Statement: Co—Ral 1% Ready—To—
Use Spray. (Unpublished st x y received May 1, 1967 under 11556—
16; CDL:126968—C).
00005417 Bayvet (1974) Co—Ral Formulator’s Manual for Dust Formulations.
Unpublished st 1y received Jan. 8, 1975 under 11556—49;
CDL;140110—B).
00005528 Bloan, D. (1969) Stability Study: Moorman’s Insecticide Dust with
(R) Co-Ral. (Unpublished st x1y received Aug. 22, 1969 under
1157—31; sulinitted by Moorman Manufacturing Co., Quincy, Ill.;
CDL:005687—A).
05002075 Brajthwaite, D.P. (1963) Detection of çtiosphorothioate pesticides,
Nature (London) 200(4910):101.
00005433 Caswell, R.L. (1962) Report on Co—Ral: Determination of Sulfotepp.
Method dated Nov. 15, 1962. Unpublished stir3y received Nov. 15,
1962 under unknown admin. no.; prepared by Chemagro Corp.,
sul:initted by Bayvet, Shawnee Mission, Kans.; CDL:124758—A).
68
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Coumaphos
Section One:
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
Product Chemistry
MRID Citation
00005193 Chemagro Corporation (1957) Co—Pal (Formerly Bayer 21/199) for
Experimental Use Only. Unpublished study received July. 1, 1957
under unknown admin. no.; sutirtitted by Bayvet, Shawnee Mission,
Kans.; CDL:l24847—A).
00005838 Chemagro Corporation (1961) Confidential Ingredient Statement: Co-
Ral Livestock Duster (5% Dust). (Unpublished study received
Mar.29, 1961 under 1F0306; CDL:092586—M).
00005188 Chemagro Corporation (1962) Chemagro Corporation Analytical Method:
Assay of chnica1 Co-Pal by Ultraviolet Spectrophotcffle try.
Method It4C—2.8 dated July 17, 1962. (Unpublished study received
Oct. 24, 1962 under unknown admin. no.; subrtitted by Bayvet,
Shawnee Mission, Kans.; CDL:124761—B).
00005187 Chemagro Corporation (1962) Chernagro Corporation Analytical Method:
Estimation of Active Ingredient in Co—Pal 25% Wettable Po x3ers
by Ultraviolet Spectrophotcinetry. Method TMC-2.6 dated July 25,
1962. Unpublished study received Oct. 24, 1962 under unknown
admin. no •; su initted by Bayvet, Shawnee Mission, Kans.;
CDL: 124761—A).
00005189 Chemagro Corporation (1962) Chemagro Corporation Analytical Method:
Estimation of Chlorferrcn in chnica1 Co-Pal by Ultraviolet
Spectrophotanetry. Method ‘I?4C—2.l0, dated June 7, 1962.
(Unpublished study received Oct. 24, 1962 under unknown admin.
no •; subnitted by Bayvet, Shawnee Mission, Kans •; CDL: 124761—C).
00021981 Chemagro Corporation (1964) Co—Pal Parasiticide. (Unpublished study
received Oct. 8, 1968 under unknown admin. no •; sutraitted by
Mobay Chemical Corp., Kansas City, Mo.; CDL:006897—A).
00005435 Chemagro Corporation (1966) Confidential Ingredient Statement: Co-
Ral 25% Wettable bwder. (Unpublished study received Dec • 21,
1967 under SF0678; CDL:092983—B).
00005345 Chanagro Corporation (1966) Confidential Ingredient Statement: Co-
Ral Exulsi fiable Concentrate: (lib . /gal.). (Unpublished study
received on unknown date under 1F0306; CDL:092586- L).
‘9
-------
Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Coumaphos
Section One:
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
Product Chemistry
MRID Citation
00005192 Costello, J.R. (19??) Co—Pal: operating Procedure. (Unpublished
sti.dy received Oct. 24, 1962 under unknown admin • ro.; sutinitted
by Bayvet, Shawnee Mission, Kans.; CDL :124761-O).
05002340 Dainico, JN. (1966) The mass spectra of sar organophosphorus
pesticide cxmpounds. Journal of the Association of Official
Analytical Chemists 49(5):1027—l045.
05013242 Drough, H.W.; Brady, U.E., Jr.; TinTnerman, J.A.; Arthur, B.W.
(1961) Residues in tissues and eggs of poultry receiving Co—Pal
(Bayer 21/199) in the feed. Journal of Economic Entorrology
54(1) :97—100.
05004089 El-Refal, A.; }bpkins, T.L. (1965) Thin—layer chromatography arid
cholinesterase detection of several phosphorothiono insecticides
and their oxygen analogs. Journal of P ricu1tural and Food
• Chemistry 13(5):477—481.
05005130 Hart nan, C.H. (1966) Phosphorus detector for pesticide analysis,
Bulletin of Environmental Contamination and Toxicology l(4):159—
168.
05004290 Kane, P.F., et al. (1960) Assay of Co—Pal in Technical Material and
Formulated Products • Journal of Agricultural and Food
Chemistry 8(1):26—29.
05012747 Kasiirov, D.C. (1969) Laboratornvi sintez ko—rala, mechenogo po P32
Laboratory synthesis of phosphorus—32 labeled Co—Pal. Th x3y,
Vsesoyuznyi Nauchno Issledovatel’skii Institut Veterinarnoi
Sariitarii. Transactions, All—Union Scientific Research Institute
of Veterinary Sanitation. 32:375—378.
05002360 Keith, L.H.; Alford, A.L. (1969) Supplementary interpretations of
the NMR spectra of phosphorus pesticides. Analytica Chimica
Acta 44(2):447—448.
05004395 Keith, L.H.; Garrison, A.W., Alford, A.L. (1968) The high resolution
NMR spectra of pesticides. Organophosphorus pesticides.
Journal of the Association of Official Analytical Chemists
51(5) :1063—1094.
70
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Coumaphos
Section One;
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
Product Chemistry
MRID Citation
00005526 Macflugall, D. (19??) Co—Ral. Pages 83—95, “In”? By ? N.P. (Also
“In” unpublished sukxnission received May 1, 1972 under 2749—135;
sutinitted by Aceto Chemical Co., Inc., Flushing, N.Y. CDL:025450—
A).
05004866 McKinley, W.P.; Bead, S.I. (1962) Esterase inhibition technique for
the detection of organophosphorus pesticides. Journal of the
Assocation of Official 4gricu1tural Chemists 45(2):467—473.
00021997 Mobay Chemical Corporation (1966) Confidential Ingredient Statement:
Co-Ral 5.0% Dust (Livestock Duster). (Unpublished study
received Oct. 8, 1968 under unkrown admin. to.; CDL:006897—AG).
05014477 Pflugmacher, J.; ElDing, W. (1978) Zur Kenntnis des
E lutionsverhaltens einiger pflanzenschutzmittelWirkstOffklasSen
bei der Galchranatographie. Evaluation of the elution behaviour
of scum classes of pesticides in gel chranatography. Journal of
Chranatography 151(2) :171—197.
00005307 Rose, W.B., White, C.E. (1971) Co—Ral: Formulator’s Manual for Dust
Formulations: Report No. 16425. Includes undated method.
(Unpublished study receved June 4, 1971 under 3125—101; sukinitted
by k bay Chemical Corp., ricultural Div., Kansas City, i;
CDL: 025735—A)
05010318 Ross, R.T.; Biros, F.J. (1970) Correlations between 31 chemical
shifts and structures of sc organophosphorus pesticides.
Analytica Chimica Acta 52(l):139—141.
05003797 Volpe, Y.; Mallet, YN. (1976) A mechanism for the neat—induced
fltrrescence of ooumaphos and related cxinpounds and the
identification of their metabolities in water. Malytica Chimica
Acta 81(l):lll—116.
00005278 Wasleski, D.M. (1953?) Colorimetric determination of Potasan in
Coumaphos. Undated method. (Unpublished study received Sep.
20, 1965 under 11556—21; prepared by Chemagro Corp., sulxdtted by
Bayvet, Shawnee Mission, Kans,; CDL:124734—A).
05003798 Wasleski, D.M. (1966) Colotmetric determination of Potasan in
Coumaphos. Journal of P gricu1tura1 and Food Chemistry 14(2): 156-
158.
71
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Office of Pesticide Progran s
Registration Standard Bibliography
Case GSOO1B Coumaphos
Section One:
Citations Considered to be Part of the t ta Base
Supporting Registration Under the Standard
Product Chemistry
ME lD Citation
00005278 Waleski, D.M. (1953?) Colorimetric t terminatiori of Potasan in
Coumaphos. Undated Method. (Unpublished stedy received Sept.
20, 1965 under 11556—21; prepared by Chemagro Corp., sukxaitted by
Bayvet, Shawnee Mission, Kans.; CDL:124734—A).
05003798 Wasleski, D.M. (1966) Colorin tric Determination of Potasan in
Coumaphos. Journal of gricu1tura1 and Food Chemistry
14(2) :156-158.
00005190 Young, J.W. (1962) Co—Ral 25% Wettable Possder Field Storage Tests:
Report 1 b. 10002. (Unpublished study received Oct. 24, 1962
under unknown admin • rx.; prepared by Chemagro Corp., sutinitted
by Bayvet, Shawnee Mission, Kans.; CDL:124761—E).
72
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Office of Pesticide Programs
Registration Standard Bibliography
Case ( SOO18 Coumaphos
Section One:
Citations Considered to be P rt of the Data Base
Supporting Registration Under the Standard
Environn nta1 Fate
MRID Citation
05005579 MacRae, I.C,; Celo, J.S. (1974) The Effects of Organophosphorus
Pesticides on the Respiration of Arotobacter vinelandji. Soil
Biology and Biochemistry 6(2) :109—111.
73
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Cournaphos
Section One:
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
Toxicology
MRID Citation
00005148 DDu I1, J., I ot, M., and Cowan, J. 1962. The Effect of Co—Hal in
the Diet on the Reproduction of Mice: Report No. 10203.
(Unpublished study received March 11, 1963, under unknown
administration number; prepared by University of Chicago,
Departsr nt of Pharmacology, su itted by Bayvet, Shawnee Mission,
Kans.; CDL: 109146—D).
00005473 DDu11, J., Vesselinovitch, D., Fitch, R., Poot, M., and Meskauskas,
3. 1960. Chronic ‘lbxicity of Co—Hal Fed to Rats for a Period of
Two Years: Report No. 6089. (Unpublished study received
Daceinber 14, 1961, under PP0299; prepared by University of
Chicago, t partments of Pharmacology and Pathology, sutii itted by
Chemagro Corp., Kansas City, b.; CDL: 09320—Y).
GS0018003 Hecht, G. (1958) The Acute ‘Ibxicity of Various Co—Hal Preparations
to Rats, Report No 3405a, Farbenfabriken Bayer, West Ge nany,
January 28, 1958 (Unpublished study; CDL:090319 and 090320).
GS0018004 Johnston, C.D., and Scott, W.J. (1965). GS13005 25W Potentiation
Studies with Other Organophosphate Insecticides in the Rat.
(Unpublished study received August 5, 1967, under 8F06481;
prepared by t,odard Research Corp., suhaitted by Geigy Chemical
Corp., Ardsley, N.Y.: CDL:091128—U).
05004087 Krueger, H.R.; Casida, J.E.; Niedermeier, R.P. (1959) Bovine
metabolism of organophosphorus insecticides——Metabolism and
residues associated with dernial application of Co—Pal to rats, a
goat, and a cow. J. Agric. Food Chem. 7:182—188 (26A—0022).
00005416 Lamb, D.W., and Anderson, R.G. 1974. Acute ‘I xicity of Co—Hal 50%
Wettable Powder to Rats and Rabbits: Report No. 41817.
(Unpublished study received January 8, 1975, under 11556—49;
prepared by Mobay Chemical Corp., subnitted by Bayvet, Shawnee
Mission, Kans,; CDL:140110—A).
O0054l5 Lamb, D.W., and Matzkanin, C.S. (1975). Eye Irritance of Co—Hal 50%
Wettable Powder to Rabbits. (Unpublished study received July
29, 1975, under 11556-49; prepared by Mobay Chemical Corp.,
sul:initted by Bayvet, Shawnee Mission, Kans,; CDLd4O1I1—A).
74
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Coumaphos
Section One:
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
Toxicology
MRID Citation
00005496 Narcisse, J.K. (1967) Final report: A rbtentiation Study in Rats in
Vapona with 26 Other Cholinesterase—inhibiting Canpounds: SRI
Project B 868—15. (Unpublished study received June 23, 1967,
under 201—125; prepared by Stanford Research Institute, subnitted
by Shell Chemical Co., Washington, D.C.; CDL:123582—A).
05009938 National Cancer Institute (Nd). (1979). Bioassay of Coumaphos for
Possible Carcinogenicity. CAS No. 56—72—4. NCI Carcinogenesis
Technical Report Series No. 96, Washington, D.C., DHEW (NIH)
Publication No. 79—1346 (26A—0054).
00005384 Vaughn, G.,, Deininger, E., and Deull, J. (1958a) Measurement of the
Safe Dietary Level of Co—Ral for flDgs: Report No. 247 2a.
(Unpublished study received October 8, 19.59, under 1F0306;
prepared by University. of Chicago, Department of Pharmacology,
sutmitted by Chemagro Corp., Kansas city, lb. CDL:090325-0).
00005504 Vaughn, G., Deininger, E. and D ull, J. (1958b) The Effects of
Diets Containing Co—Ral (Bayer 21/199) on Rats: Report No
2455a. (Unpublised study received September 20, 1960, under
11556—li; prepared by University of Chicago, Department of
Pharmacology, sutmitted by Bayvet, Shawnee Mission, Kans,;
CDL: 109120—B).
05012220 Vickery, D.S., and Arthur, B.W. (1960) Animal systemic activity,
metabolism, stability of Co-Ral (Bayer 21/199.) J. Econ.
Entaio. 53:1037—1043.
75
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOOI8 Counaphos
Section ( ie:
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
Residue Chemistry
MRID Citation
00005289 Adams, J. (1964) A Quantitative Method for the Determination of
Residues of Co-Ral (O—03-thloro-4-methyl inpelliferoneJ. 0,0—
Diethyl phosphor.vthioate) and Chiorferron (3-Chloro-4-methyl-.-7 -
hydroxycounarin) in Animal Tissues and Milk: Report No. 13656.
Method dated May 6, 1964. (Unpublished study received Aug 18,
1966 under 7F0612; subnitted by Chemagro Corp., Kansas City, r b.;
CEL:090796—K).
00005328 k ams, J.M. (1961) A quantitative method for the determination of
residues of Co-Pal and thiorferron in animal residues. Report
No. 7165. (Unpublished study dated June 13, 1961). Sut nitted by
Chemagro Corp., Kansas City, tb.; CDL: None.
00005342 Adams, J.M. (1963) A Quantitative Method for the Determination of
Residues of Co-Pal (0—3—thloro-4--methyl unpelliferone) 0,0—
Diethyl. phosphorothioate) and Chiorferron C3-Ch1oro-4-n thy1-7-
hydroxycounarin) in Animal Tissues and Milk: Report No. 7165,
Rev. (pp. 1—6 only; unpublished study received on unkn n date
under 1F0306; subuitted by Cheinagro Corp., Kansas City, ! b.;
CDL:092586—G).
00005395 Adelman, D. (1958) Summary: Co—Ral Residues in Cattle Fat (Biopsy):
Report No. 2408. (Unpublished study including report no. 2447a,
received Oct. 8, 1959 under 1F0306; prepared in cooperation with
U.S. Agricultural Research Service, sutxnitted by themagro Corp.,
Kansas City, lb.; CIL:090326—D).
00005448 Anderson, C.A. (1959) Co—Ral Residues in thicken Tissues and Eggs:
Report No. 4010. (Unpublished study received Mar 10, 1961 under
PP0299; prepared in cooperation with Univ. of California--
Riverside, Agricultural Experiment Station, subuitted by themagro
Corp., Kansas City, ?t.; CDL:090337—N).
00005451 Anderson, C.A. (1959) Co—Pal Residues in thicken Tissues: Report
No. 4323. (Unpublished study received Mar 10, 1961 under
PP0299; prepared in cooperation with Clemson Univ., Dept. of
tmo1ogy, subuitted by themagro Corp., Kansas City, Mo ,;
CIL:090337—U).
00005453 Anderson, C.A. (1959) Co—Pal Residues in thicken Tissues: Report
No. 4421. (Unpublished study received Mar 10, 1961 under
PP0299; prepared in cooperation with M ifl Univ., MoDenald
College, Dept. of u1try Husbandry, subnitted by themagro Corp.,
Kansas City, Z’b.; CIL:090337—W).
76
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Cou aphos
Section One:
Citations Considered to be Part of the Data Base
Su orting Registration Under the Standard
Residue themistry
MRID Citation
00005074 Anderson, C.A. (1959) Co—Ral Residues in Goat Tissues: Report No.
4008. (Unpublished study received Sep 11, 1959 under 11556—21;
prepared by th magro Corp., sulinitted by Bayvet, Shawnee Mission,
Kans.; CDL:0l1001—A).
00005161 Anderson, C.A. (1959) Co-Ral Residues inibg Tissues: Report No.
3758. (Unpublished study received May 25, 1959 under 11556—21;
prepared by themagro Corp., sthnitted by Bayvet, Shawnee Mission,
Kans.; CDL:124730—A).
00005400 Anderson, C.A. (1959) Co-Ral Pec idues in }bg Tissues: Report lb.
4009. (Unpublished study received Oct 8, 1959 under 1F0306;
suI nitted by themagro Corp., Kansas City, sb.; CDL: 090326-0).
00005195 Anderson, C.A. (1958) A Photofluoranetric Method for the
Determination of Co—Ral (Bayer 21/199) Residues in Animal
Tissues: Report No. 2216. MethOd dated Aug. 13, 1958.
(Unpublished study received Feb. 27, 1976 under 11556-Ex—3;
prepared by themagro Corp., suk nitted by Bayvet, Shawnee Mission,
Kans.; CDL:224167—E).
05004066 Anderson, C.A.; iams, J.M.; McEXugall, D. (1959) Photofluoranetric
method for determination of Co-Ral residues in animal tissues.
Journal of 1 ricu1tura1 and Food themistry 7(4):256-259.
05002359 Askew, 3.; Ruzicka, 3.11.; Wheals, B.B. (1969) OrganophosphoruS
pesticides: a gas chrunatographic screening technique based on
the detection of methylated hydrolysis products. Journal of
thranatography 41(2) :180—187.
00005509 Bayvet (1968) Synopsis of Analytical and Residue Information for
Spray A lication of Cb-Ral to Dairy Cattle. SutTnary of studies
102084—B through l02084-G. (Unpublished study received Feb. 20,
1970 under 11556—21; CDL:102084—A).
00005186 Bayvet (19??) Residues of Bayvet 21/199 in Fat and Liver Tissues of
Cattle Sprayed with The Insecticide. (Unpublished study
received on unknown date under unknown adrnin. no.; CDL: 124765—A).
05016099 Beroza, M.; Sc nan, M.C. (1971) Instrunentation in determination of
organophosphorus terminal residues. Pages 79-92, •Th” Pesticide
Terminal Residues: Invited Papers fran the International
Syniposiun on Pesticide Terminal Residues; Feb. 17—19, 1971, Tel
Aviv, Israel. Fthted by A.S. Tehori. London: Butter rths.
77
-------
Office of Pesticide Programs
Registration Standard Bibliography
Case GS0018 Coumaphos
Section One:
Citations Considered to be Part of the t ta Base
Supporting Registration Under the Standard
Residue Chemistry
MR [ D Citation
05004211 Bowman, M.C.; Beroza, M. (1967) Temperature—progranirted gas
chranatography of 20 phosphorus-containing insecticides on 4
different columns arid its application to the analysis of milk and
corn silage. Journal of the Association of Official Analytical
Chemists 50(6) :1228—1236.
05010096 Bowman, M.C., et al (1968) A Method of Analyzing the 01 of 01 milk
Feces of Cows for Coumaphos for Control of Ibuse Fly.
05005125 Burnett, E.M. (1970) Pesticide residues in fat of cattle treated
with backrubbers impregnated with coumaphos, methoxychior or
DtlT. Pesticide Science l(2):70—72.
00005483 Chemagto Corporation (1959?) Synopsis of Analytical and Residue
Information for Cattle, Swine, and P u1try Tissues (Co—Ral——Feed
and Salt &3ditives). Suiruiary of studies 090319—U through 090319—
Y and 090319—M through 090319—AC. (Unpublished study received
Feb. 11, 1964 under PP0299; CDL:090319—U).
00005392 Chemagro Corporation (1959) Synopsis of Metabolic, Analytical
Residue, and Taste I ta on Co-Hal. Sumliary of studies 090326—B
through 090326—U. (Unpublished study received C t. 8, 1959 under
1F0306; CDL:090326—A).
00005333 Chemagro Corporation (1960) Residue Report: Report ND. 5515.
(Unpublished study including report nos. 5533 and 5534, received
Sep. 4, 1961 under PP0306; CDL:090321—H).
00005480 Chemagro Corporation (1960) Residue Report: Report ND. 6101.
(Unpublished study received Mar. 10, 1961 under PP0299;
CDL:090337—1 K).
00005456 Chemagro Corporation (1960) Residue Report: Report ND. 6102.
(Unpublished study received Mar. 10, 1961 under PP0299;
CDL:090337—AA).
00005840 Chemagro Corporation (1960) Residue Report: ND. 6103. (Unpublished
study received Mar. 10, 1961 under PP0299; CDL:090337—AB).
00005842 Chemagro Corporation (1960) Residue Report: Report ND. 6141.
(Unpublished study received Mar. 10, 1961 under PP0299;
CDL:090337—AJ).
78
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOOI8 Coumaphos
Section One:
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
Residue Chemistry
MRED Citation
00005440 Chemagro Corporation (1960?) Synopsis of Residue Information on
Poultry Meat and Bggs (EXist Box, Spray) * Sumary of studies
091185—E and 091185—C. (Unpublished study received June 14, 1968
under 8F0678; CDL:091185—F).
00005837 Chemagro Corporation (1961) Confidential Ingredient Statement: Co-
Ral 25% Wettable Powder. (Unpublished study received Mar. 29,
1961 under 1F0306; CDL:092586—I).
00005493 Chemagro Corporation (1961) Ch nagro Confidential Residue Experiment
No. ?: Report No. 7167. (Unpublished study received on unknown
date under PP0229; CDL:092579—C).
00005492 Chemagro Corporation (1961) Chernagro Corporation Residue Experiment
No. SE 205—61—D: Report No. 7166. (Unpublished study received
on unknown date under PP0299; CDL: 092579—B).
00005441 Chemagi:o Corporation (1961) Chemagro Confidential Residue Report:
Report No. 6101. (Unpublished study including report r s . 6102—
6104, 6141—6142, 7155—7156, 7159, 7166 and 7248, received June
14, 1968 under 8F0678; CDL:091185—G).
00005331 Chemagro Corporation (1961? Synopsis of Analytical and Residue
Infotmation on Co—Ral: (Milk). &nrrnary of studies 090321—F
through 090321—H. (Unpublished study received Sep. 4, 1961 under
PP0306; CDL:090321—E).
00005485 Chemagro Corporation (1962) Residue Experiment ?: Report No. 8300.
(Unpublished study received Feb. 11, 1964 under PP0299;
CDL:090319—W).
00005486 Chemagro Corporation (1962) Chemagro Corporation Residue Experiment
No. KC-209-62H: Report No. 9721. (Unpublished study received
Feb. 11, 1964 under PP0299; CDL:090319—X).
00005822 Chemagro Corporation (1963) Chemagro Corporation Residue Experiment
No. KC—203—63D: Report No. 11449. (Unpublished study received
July 9, 1963 under 11556—21; suI iitted by Bayvet, Shawnee
Mission, Karis.; CDL:025716—A).
79
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Office of Pesticide Prograns
Registration Standard Bibliography
Case GSOOI8 Cotmiaphos
Section ( ie;
Citations Considered to be Part of the Data Base
Su çorting Registration Under the Standard
Residue Chemistry
MRID Citation
00005056 Chemagro Corporation (1963) Cheni gro Corporation Residue Experu ent
No. KC-2l5-63D Report No. 12541. (Unpublished study including
letter dated Jan. 22 1964 frm G.G. Stetson to G.M. Dwnard,
received Jan. 28. 1964 under 11556-21; sut itted by Bayvet
Shawnee Mission, Kans.; CDL 025715 A).
00005491 chemagro Corporation (1963) Cheniagro Corporation Residue Experiment
No NW-203 62DC Report No. 11447. (Unpublished study received
Feb. 11, 1964 under PP0299; CDL 090319—AC).
00005329 Chemagro Corporation (1963) Report No. 10867: thloroferroni.
(Unpublished study received on unknown date under PP0306;
CDL 09032l C).
00005834 Chemagro Corporation (1964) Chemagro Corporation Residue Experiment
No. ?: Report No. 13100. (Unpublished study received Dec. 21,
1967 under 11556 11; suhinitted by Bayvet, Shawnee Mission, Kans.;
CDL:121477—G).
00005831 Chemagro Corporation (1964) Chemagro Corporation Residue Experiment
No. KC-201-64D: Report No. 13856. (Unpublished study received
June 4, 1965 under 11556 16; sulznitted by Bayvet, Shawnee
Mission, Kans.; CDL:126094—C).
00005830 Cheinagro Corporation (1964) themagro Corporation Residue Experiment
No.KC—200—64D: Report No. 13875. (Unpublished study received
June 4, 1965 under 11556 -l6; su nitted by Bayvet, Shawnee
Mission, Kans.; CDL:126094—B).
00005832 Chemagro Corporation (1964) Chemagro Corporation Residue Experiment
No. KC-202-63D Report No. 12866. (Unpublished study received
Dec 21 1967 under 11556 11; subnitted by Bayvet, Shawnee
Mission, Kans.; CDL:121477—E).
00005214 Chemagro Corporation (1964) themagro Corporation Residue Experiment
No. KC-206, 207—64D: Report No. 14361. (Unpublished study
received Dec 21 1967 under 11556 11; subnitted by Bayvet,
Shawnee Mission Kans.; CDL:121477—1).
00005317 theniagro Corporation (1964) Chemagro Corporation Residue Experiment
No. KC—214-63D: Report No. 12786. (Unpublished study received
June 8, 1964 under 3125 124; sutinitted by t.bbay Chemical Corp.
1 qricu1tura1 Div., Kansas City, Mo.; CDL:005791—B).
80
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Cotinaphos
Section One
Citations Considered to be Part of the t ta Base
Supporting Registration Under the Standard
Residue Chemistry
MRID Citation
00005235 Chemagro Corporation (1964) Chemagro Corporation Residue Experiment
No. KC—214-63D: Report No. 12786. (Unpublished study received
June 8, 1964 under 11556 25; suthtitted by Bayvet, Shawnee
Mission Kansas.; CDL 1 :102326—B).
00005833 Chemagro Corporation (1964) Chemagro Corporation Residue Experiment
No. NC-202--63D: Report No. 12867. (Unpublished study received
Dec. 21. 1967 under 11556-11; subnitted by Bayvet, Shawnee
Mission, Kans.; CDL:121477—F).
00005336 Chemagro Corporation (1964?) Synopsisof Analytical and Residue
Information for Spray Application of Co-Ral to Deiry Cattle,
Sunmary of studies 09( 21 S through 090321-V. (Unpublished study
received on unknown date under PP0306; CDL:090321—R).
00005293 Chemagro Corporation (1966) Chemagro Corporation Residues Experiment
No. KC—3400-66D: Report No. 17971. (Unpublished study received
Aug. 18 1966 under 7F0612; CDL 090796 Q)
00005295 Che!nagro Corporation (1966) themagro Corporation Residue Exeriment
No. KC -340l 66H: Report No. 18522. (Unpublished study received
Aug. 18, 1966 under 7F0612; CDL;090796—S).
00005338 Chemagro Corporation (1966) Synopsis of Analytical and Residue
Information for [ xist Application to Cattle. Suninary of studies
092586 B, 092586 D through 092586-E and 092586 G. (Unpublished
study including supplement, received Mar. 18, 1968 under 1F0306;
CIL:092586 A).
00005047 themagro Corporation (1967) Chemagro Corporation Residue Experiment
No. KC—201—66D: Report No. 20654. (Unpublished study received
Dec. 15, 1967 under 11556 19; su itted by Bayvet, Shawnee
Mission, Kans,; CDL:014008—D).
00005339 Chemagro Corporation (1967) Chemagro Corporation Residue Experiment
No. KC—201—67D: Report No. 20599. (Unpublished study including
report nos. 20651, 20663 and 20677, received Mar. 18, 1968 under
1F0306; CDL:092586—B).
00005048 Chemagro Corporation (1967) Chemagro Corporation Residue Experiment
No. KC-300—66H: Report tb. 20964. (Unpublished study received
Dec. 15, 1967 under 11556 19; subnitted by Bayvet, Shawnee
Mission, Kans.; CDL:0l4008—E).
81
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOOJ.8 Coumaphos
Section One:
Citations Considered to be Part of the L ta Base
Supporting Registration Under the Standard
Residue Chemistry
MRID Citation
00005051 Chemagro Corporation (1968) Chemagro Corporation Residue Experiment
No. ?: Report No. 23942. (Unpublished study received July 23,
1970 under 11556 16; subnitted by Bayvet, Shawnee Mission, Kans.;
CDL:007188-A).
00005439 Chemagro Corporation (1968) Chemagro Corporation Residue Experiment
No. KC—203 --68D: Report No. 22808. (Unpublished study including
report nos. 22809 --228fl. received June 14, 1968 under 8F0678;
CDL:091185—D).
00005510 Chemagro Corporation (1968) Recovery of Co—Ral f aii Milk: Report
No. 22697. (UnpUblished study received Feb. 20, 1970 under
11556 -21; suthiitted by Bay iet, Shawnee Mission, Kans.; CDLI 102084
E).
00005437 Chemagro Corporation (1968) Synopsis of Analytical and Residue
Information on Application of Cowiaphos (Co-Ral, Baymix,
Meldane) to Poultry. St.mnary of studies 092983-B, 092983—C, and
091185-B through 091185-E. (Unpublished study received June 14,
1968 under 8F0678; CDL:091185-A).
00005511 Chemagro Corporation (1969) Chemagro Corporation Residue Experiment
No. KC-200-68D: Report No. 24050. (Unpublished study received
Feb. 20, 1970 under 11556—21; sukinitted by Bayvet, Shawnee
Mission, Kans.; C1L102084 F).
00005080 Chemagro Corporation (1969) Synopsis of analytical and residue
information for spray application of Co—Ral to dairy cattle.
suninary of studies 006078-B through 006078-G. (Unpublished study
received Feb. 20, 1970 under 11556-21; sul uitted by Bayvet,
Shawnee MiSsion, Kans.; CDLI: 006078—A).
00005081 Chemagro Corporation (1969) Chernagro Corporation Residue Experiment
No KC—201--68D: Report No. 24216. (Unpublished study received
Feb. 20, 1970 under 11556 21; sukinitted by Bayvet, Shawnee
Mission, Kans.; CDL:006078-G).
00005042 Chemagro Corporation (1971) Chemagro Corporation Residue Experiment
Nos. AU 70G—810, All 71G-818: Report No. 30331. (Unpublished
study received Oct. 29.. 1971 under 11556-4; suthdtted by Bayvet,
Shawnee Mission, Kans.; CDL:010122—F).
82
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Cotii aphos
Section e:
Citations Considered to be Part of the t ta Base
Supporting Registration Under the Standard
Residue Chemistry
MRID Citation
00005490 Ditman, L.P. (1963) Chemagro Corporation Residue Experiment . EC—
200-63D: Report r . 11372. (Unpublished study received Feb. 11,
1964 under PP0299; prepared by Univ. of Maryland, Dept. of
Entanology, Insecticide Laboratory, sthnitted by Chemagro Corp.,
Kansas City, !b.; CDL:090319—AB).
00005450 D3urrongh, H.W.; Brady, O.E., Jr.; Tininerman, J.A.; Arthur, B.W.
(1959) Magnitude and Nature of Residues in Tissues and E jgs of
Poultry EXIsted with 32P Co-Ral: Progress Report: Report No.
4209. (Unpublished study received Mar. 10, 1961 under PP0299;
prepared by Alabama Polytechnic Institute, Dept. of Zoology-
Entcztology, subuitted by Chemagro Corp., Kansas City, lb.;
CDL: 090337—1)
00005454 Eburrough, H.W,; Brady, U.E., Jr.; Tininerman, J.A.; Arthur, B.W.
(1959) Magnitude and Nature of Residues in Tissues and Bggs of
Poultry Receiving 32P Co-Ral: Mixed in the Feed: Progress Report:
Report lb. 4425. (Unpublished study received Mar. 10, 1961 under
PP0299; prepared by Alabama Polytechnic Institute, Dept. of
Zoology-Entarology, suhuitted by th nagro Corp., Kansas City,
lb.; CDL 1 :090337—X).
05008968 Dzrough, H.W.; Brady, U.E., Jr.; Timerman, L.A., Arthur, B.W.
(1961) Residues in tissues and eggs of poultry dusted with Co-
Ral (Bayer 21/199). Journal of E) onanic Entanology 54(1):25—30.
05013242 D rough, H.W.; Brady, U.E., Jr.; Tininerman, J.A.; Arthur, B.W.
(1961) Residues in tissues and eggs of poultry receiving Co-Ral
(Bager 21/199) in the feed. Journal of Econanic &itanology
54(1) :97—100.
05012915 FPL) rking Party of Experts on Pesticide Residues (1973)
Counaphos. Pages 211—217, “In” 1972 Evaluations of Sane
Pesticide Residues in Fbod. By the FN) Working Party of Experts
on Pesticide Residues and the WHO Expert Oxinittee on Pesticide
Residues • Geneva, Switzerland: br1d Health Organization, (WHO
pesticide residues series no. 2).
00005396 Gronberg, R.R. (1958) Co—Ral Residues in Cattle Tissues: Report
No.2409. (Unpublished study received Oct. 8, 1959 under 1F0306;
prepared in oooperation with U.S. J riculturaI Research Service,
sukinitted by themagro Corp., Kansas City, Mo.; CDL:090326-E).
83
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Coumaphos
Section One:
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
Residue Chemistry
MRID Citation
00005399 Gronberg, R.R. (1958) Co—Ral Residues in Cattle Tissues: Report
bb.2556. (Unpublished stedy received Oct. 8, 1959 under 1F0306;
prepared in oDoperation with Science Service Laboratory, Live-
stock Insect Section, suhnitted by Chemagro Corp., Kansas City,
b.; CDL:090326—I).
00005479 Gronberg, R.R. (1958) Co—Ral Residues in Cattle Tissues: Report
I’b.2409. (Unpublished stuiy including report no. 2447a,
received Feb. 14, 1961 under PP0299; prepared in ocoperation with
U. S. Dept. of l ricuiture, sulinitted by Chemagro Corp., Kansas
City, Yb.; CDL:090320—AH).
05004690 Hurwood, I.S. (1966) Studies on pesticide residues—i—Excretion of
pesticides in milk following dermal treatment of dairy cattle
with coumaphos and dioxathion. Queensland Journal of
P ricultura1 and Animal Sciences 23(4):555—562.
00005082 Industrial Bio-Test Laboratories (1974) Chemagro Division of Baychem
Corporation Residue Experiment: AH—74A—929: Report Yb. 40709.
(Unpublished stu5y received June 20, 1974 under 11556—21;
prepared for Baychem Corp., sutmitted by Bayvet, Sha e Mission,
Kans; CDL:009815—A).
05004483 Kaplanjs, J,N.; 1bpkins, D.E.; Treiber, G.H. (1959) Dermal and oral
treatments of cattle with phosphorus—32—labe led Co—Ral, Journal
of Ps ricultural and Food Chemistry 7(7):483—486.
05012748 Kasinov, D.D. (1969) Metabolism ko-rala v organi te krolikov i
krupnogo rogatogo skota. Co-Ral metabolism in rabbits and
cattle. Pr x1y, Vsesoyuznyi Nauchno-Issledovatel’skii Institut
Veterinarnoi Sanitarii. Transactions, All—Union Scientific
Research Institute of Veterinary Sanitation. 32:379—387.
050???? Knapp, F.W. (1962) 1 ultry tolerance to excessive amounts of Co—Ral
dust.
05004087 Krueger, H.R.; Casida, J.E.; Niedermeier, R.P. (1959) Bovine
metabolism of organophosphorus insecticides—Metabolism and
residues associated with dermal application of Co—Ral to rats, a
goat, and a cow. J. Agric. Food Chem. 7:182—188 (26A—0022).
84
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Office of Pesticide Programs
Registration Standard Bibliography
Case GS0018 Coumaphos
Section One:
Citations Considered to be Part of the t ta Base
Supporting Registration Under the Standard
Residue Chemistry
MRtD Citation
00005332 Kruegar, H.R.; Casida, J.E.; Niedermeier, R.P. (1961) Co—Pal
Residues in Cows Milk Following a Single Spray 1 pplication:
Report 1b. 2213(a). (Unpublished study received Sep. 4, 1961
under PP0306; prepared by Univ. of Wisconsin, t pts. of
Entci ology and 1 iry Husbandry, sutrnitted by Chemagro Corp.,
Kansas City, tb.; CDL:090321—F).
05005830 Matthysse, J.G.; Lisk, D. (1968) Residues of diazinori, coumaphos,
Ciodrin, methoxychior, and rotenone in cow’s milk frau
treatments similar to those used for ectoparasite and fly control
on dairy cattle, with notes on safety of diazinon and Ciodrin to
calves. Journal of Fconc*nic Entcirology 61(5):1394—1398.
05017521 McLeod, H.A.; Butterfield, A.G.; Lewis, D.; Phillips, W.E.J.;
Coffin, D.E. (1975) Gas—liquid chrcsnatography system with flame
ionization, phosphorus, sulfur, nitrogen, and electron capture
detectors operating simultaneously for pesticide residue
analysis. na1ytical Chemistry 47(4):674—679.
00005308 !bbay Chemical Corporation.(l964) Synopsis of 1i na1ytica1 and Residue
Infoim aticn on Co-Pal. Sumnary of study 005791—B. (Unpublished
study received June 8, 1964 under 3125—124; CDL:005791—A).
05006630 Oehler, D.D.; Eschle, J.L.; Miller, J.A.; Claborn, H.V.; Ivey, M.C.
(1969) Residues in milk resulting frau ultra-low-volume sprays
of malathion, methoxychior, coumaphos, ronnel, or Gardona for
control of the horn fly. Journal of Ec,onc*uic Enta logy
62(6) :1481—1483.
00005040 Olson, T.J. (1971) A Gas Chranatographic Confirmatory Residue
Procedure for Cr) Co-Pal and its Oxygen Anaolg: Report tb.
30279. Method dated 1 june 16, 1971. (Unpublished study received
Oct. 29, 1971 under 11556—4; prepared by Chemagro Corp.,
suk iuitted by Bayvet, Shawnee Mission, Kans •; CDL: 010l22—D).
00005401 Radeleff, R.D.; Claborn, H.V. (1957?) Ecreticri of Co-Pal by
t actating I iry Cattle: Report tb • 4161 • Undated method.
(Unpublished study received Oct. 8, 1959 under 1F0306; prepared
by U.S. P ricultural Research Service, E tawlogy Research Div.
in cooperation with animal Disease and Parasite Research Div.,
sutinitted by Chemagro Corp., Kansas City, lb.; CDL: 090326—P).
85
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Office of Pesticide Programs
Peg istration Standard Bibliography
Case GSO 018 Cou’riaphos
Section C ie:
Citations Considered to be Part of the t ta Base
Su orting Registration Under the Standard
Residue Chemistry
MRID Citation
05003806 Radeleff R.D.; Claborn, H.V. (1960) Excretion of Co-Ral in the milk
of dairy cattle. Journal of i gricu1tura1 and Food
Chemistry. 8(6):437 439.
00005402 1 bbins, W.E.; }bpkins, T.L.; L rr , D.I.; Eddy, G.W. (1959)
Studies with P-32-Bayer 21/199 sprayed on cattle. Journal of
Econanic Entaiiology 52(2):214—217. (Report no. 4168; also
“In”unpublished sthTtission received Oct. 8, 1959 under 1F0306;
sukxnitted by Chemagro Corp., Kansas City, Mo.; CDL:090326-R).
00005323 Padrigues, J.L. (1958?) Report for Year Ending December 31, 1958:
Preliminary Results of Experiments with Co_Pal for Controlling
Insect Pests of thickens: Report tb. 4460. (Unpublished study
received Dec. 16, 1959 under 1F0306; prepared by Univ. of
California-Riverside, 1 ricu1tura1 Experiment Station and Citrus
Experiment Station, Dept. of Entciiology, sutinitted by Cheinagro
Corp., Kansas City tb.; CDL:092080-K).
05108561 Thornburg, W. (1971) Pesticide residues. Analytical Chemistry
43(5) :145162.
00005438 Thornton, J.S. (1968) Determination of Co—Ral in )ggs by Thermionic
fluission Flame Gas Chrcii atography: Report tb. 2052. Method
dated Feb. 20, 1968. (Unpublished study including report no.
22053, received June 14, 1968 under 8F0678, sutinitted by themagro
Corp., Kansas City Mo.; CDL 09l185C).
05003799 Zakrevsky J.G.; Mallet, V.N. (1975) Determination of coumaphos and
its oxygen analog in eggs by in situ fluorcinetry. Journal of
the Association of Official Analytical Chemists 58(3):554—556.
05006806 Zweig, G., ed.; Sherma, J., ed. (1972) Co—Ral (Counaphos). Pages
332—339, “In” Analytical Methods for Pesticides and Plant Grci ’ith
Regulators. Vol. VI Gas thrar tographic Analysis. New York:
Academic Press.
86
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Office of Pesticide Programs
Registration Standard Bibliography
Case C OOl8 Coumaphos
Section One:
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
Ecological Effect
MRID Citation
05009242 Sanders, H.O. (1969) ‘Ibxicity of Pesticides to the Crustacean
Ganu arus lacustris . Washington, D.C: U.S. Bureau of Sport
Fisheries and Wildlife; Technical Paper 25.
05017538 Sanders, H.O. (1972) ‘Dzxicity of Scine Insecticides to Four Species
of Malacostracan Crustaceans ( Ganmarus fasciatus) .
Washington, D.C. U.S. Dapt. of the Interior, Fish and Wildlife
Service, Bureau of Sport Fisheries and Wildlife; Technical Paper
66.
87
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Coumaphos
Section One:
Citations Considered to be Part of the Data Base
Supporting Registration Under the Standard
Efficacy
MRID Citation
00005088 Bayvet. (1961) Synopsis of Biological Performance of Co—Pal on flDgs
by ‘Ibpical Application. Suirniary of studies 014009—A through
014009—B and 014009—D through 014009—F. Unpublished study
received Apr. 25, 1961 under 11556—22; CDL:014009—C).
00005028 Bayvet. (1971) Synopsis of Biological Performance of Co—Pal 1% Dust
ministered to Cattle with Shaker Cans for the Control of Cattle
Lice and Horn Flies. Suim ary of studies 004549-B through 004549—
M. (Unpublished study received Oct. 29, 1971 under 11556—4;
CDL: 004549—A).
05007632 Fox, I. et al. (1966) Ibxicity of Various Insecticides to Xenopsylla
cheopis. American Journal of Tropical Medicine and Hygiene .
15(4):611—613. — ________ ________ _______
GS0018002 Genung, W. (1959) Letter and Table 1 scribing Control of Brown Dug
Tick. Bayvet Division, Cutter Laboratories, Inc.; Report No.
3948. (Unpublished study).
05011422 Knapp, F.W. (1962) Co-Pal as a Litter and Nest Dust to Control the
Chicken Body Louse. Journal of Econcinic EntczTology . 55(4): 571—
572.
00005200 Kohier, P.H. (1967) Louse Control Studies Using Dust Bags Containing
Co—Pal (1% and 5%) and Tiguvon (5%): Report I b. 220696.
(Unpublished study received Jan. 16, 1970 under 11556—15;
prepared by South Dakota State Univ. 1 gricultura1 Experiment
Station, for Mabay Chemical Corp., subnitted by Bayvet, Shawnee
Mission, Kans.; CDL:007l68—C).
00005033 Minter, R.W. (1970) Evaluation of 1% Co—Pal Dust in Shaker Cans for
Louse Control in Cattle. Report It,. 29365. (Unpublished study
received Oct. 29, 1971 under 11556-4; prepared for Chemagro
Corp., sutinitted by Bayvet, Shawnee Mission, Kansas.; CDL:004549—
H).
00005344 Skaptason, J.S. (1959) Co—Pal Treatnent of Dugs. Report No. 4474.
(Unpublished study received Dac. 16, 1959 under 1F0306;
sutm itted by Chemagro Corp., Kansas City, Mo.; CDL:092080-Q).
88
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Coumaphos
Section One:
Citations Considered to be Part of the Deta Base
Supporting Registration Under the Standard
Efficacy
MRID Citation
00005211 Skaptason, J.S.; MacDougall, D. (1960) Co-Pal—-A Dog Tolerance
Study: Report 1 b. 5133. Includes method dated Oct. 1, 1958
entitled: Determination of Blood Cholinesterase Activity of tho1é
Blood of Cattle. (Unpublished study including report ro. 2598,
received Apr. 22, 1960 under 11556—12; prepared by Cheinagro
Corp., sutmitted by Bayvet, Shawnee Mission, Kans.; CDL:109077—B).
00005352 Smith, C.L.; Richards, R. (1955) Evaluations of Sane New
Insecticides cn Livestock and ibultry. Journal of Econanic
Entonology , 48(5):566—568. (Report ro. 1190; also “In”
unpublished sutmission received Apr. 4, 1958 under 1F0306;
sukxnitted by Chemagro Corp., Kansas City, lb.; CDL:092081—F).
CSOO1800 I Stuart, W. (1959) Control of Pests on Dogs. Bayvet Division, Cutter
Laboratories, Inc., Report tb. 4467. (Unpublished study).
00005087 Stuart, W.R. (1960) Sumary of Dog Dipping Operations with Co—Pal
Suspensions. (Unpublished study including report ros. 6398—6404
and letter dated Dec. 14, 1960 fran W.R. Stuart to Posemarie von
Rumker, received Apr. 25, 1961 under 11556—22, prepared for
Cheinagro Corp., suk:mitted by Bayvet, Shawnee Mission, Kans.;
CDL: 014009—B).
00005326 Williams, G.M. (1959). Co—Pal Treatment of Dog: Report lb. 4473.
(Unpublished study received Dec. 16, 1959 under 1F0306;
subnitted by Chemagro Corp., Kansas City, f ’b •; CDL: 092080—0).
89
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOOI8 Counaphos
Section Two:
Studies Examined and Jixiged ¶Eb Be
Inappropriate for Use in Developing
the Standard
MRID Citation
05011414 kikiris, T.R., Jr., Kropf, D.H., and V&x,ds, S.G. (1963). Residue
deposition of Co—Hal in the tissues of back—line—treated
cattle. J. Econ. Entanol. 56:759—761.
00005484 Niderson, C.A. (1959) Co—Hal residues in chicken tissues: Report
. 3765. (UnpubliShed study received Feb. 11, 1964 under
PP0299; prepared in cooperation with Univ. of Hawaii, Dept. of
Enta logy, sutinitted by themagro Corp., Kansas City, pt).;
CDL:090319—V).
00005447 Anderson, C.A. (1959) Co—Hal residues in chicken tissues: Report
. 3869(b). (Unpublished study received Mar. 10, 1961 under
PP0299; prepared in cooperation with Univ. of California——
Riverside, Dept. of Entomology, sul nitted by Chemagro Corp.,
Kansas City, pb.; CDL:090337—K).
05004394 Askew, J.; Ruzicka, J.H.; Wheals, B.B. (1969) A general method for
the determination of or anophosphorus pesticide residues in
river waters and effluents by gas, thin-layer and gel
chromatography. Analyst 94(11l7):275—283.
05011413 Axtell, R.C. (1966) Comparative ‘Ibxicities of Insecticides to Ibuse
Fly Larvae and Macrocheles muscaedomestica , a Mite Predator of
the Ibuse Fly. Journal of Economic Ent i o1ogy 59(5): 1128—1130.
05002073 Barney, J. E., II (1965) N w Spray Tests for Detecting Organo—
phosphorus Cc*npounds on Thin-Layer thrcinatogr ns. Journal of
Chromatography 20(2) :334—341.
00005075 Bayvet (1960) Suçplement to Sulinary of Performance Reports on Co-
Ral in Dip Vats for Fleeceworm Control, and as a Dest on Degs
and Rultry. Sumary of studies 014019—C through 014019—D.
(Unpublished study received Feb. 25, 1960 under 11556—21;
CDL:014019—A).
00005213 Bayvet (1963) Synopsis of analytical and residue information for
cattle, swine, annd poultry tissues: (Co-Hal——Feed and Salt
kiditives). (Unpublished study received Dec. 21, 1967 under
11556—11, CDL:121477—A).
90
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO I8 Coumaphos
Section Two:
Studies Examined and Judged ‘lb Be
Inappropriate for Use in Developing
the Standard
MRLD Citation
00005210 Bayvet (1964?) Co—Ral 1% Ready—to-Use Fly Spray. Sununary of studies
126094—B and 126094—C. (Unpublished study received June 4, 1965
under 11556-16; CDL:126094—A).
00005170 Bayvet (1965) Supplement to Synopsis of Biological Performance of Co-
Ral 0.25% Neguvon 0.5% Pressurized Spray for Ectoparasite
Control on Degs.
00005045 Bayvet (1967) Synopsis of analytical and residue information for
dust application to cattle. Suninary of studies 014008—B
through 014008—G. (Unpublished study received Dec. 15, 1967
under 11556—19; CDL:014008—A).
05004061 Bellows, R.A., Rumsey, T.S., Kasson, CW., Bond, J., Warnick, E.J.,
and Pahnish, 0. F. (1975). Effects of organic phosphate systemic
insecticides on bovine embryonic survival and developnent. Pm.
J. Vet. Res. 36:1133—1140.
05008969 Blune, R.R., et al. (1976) Effects of Residues of Certain
Anthelmintics in Bovine Manure on Onthophagus gazella , a non-
target organism. Southwestern Entonologist 2(1) :100—103.
00005378 Bombinski, T.J., and t*.iBois, K.P. (1975). 1 ute ¶Ibxicity and
Pharmacological Effects of 0, 0—Diethyl—0-Diethyl—0— C 3—chloro-4—
methyl—7-counarinyl)phosphorothioate (Bayer 21/199): Report Ne.
1924. (Unpublished study received August 31, 1959, under 1F0306;
prepared by University of Chicago, Department of Pharmacology,
subnitted by themagro Corp., Kansas City, rb.; CDL:090324-K).
05004554 Bourne, S. (1978) Preservation of organophosphorus pesticides in
water samples. Journal of Environmental Science and Health,
Part B 13(2):75—86.
05004291 Brodeur, J., and DiBois, K.P. (1963) Comparison of acute toxicity of
antichloinesterase insecticides to weanling and adult male
rats. Proc. Soc. Exp. Biol. Med. 114:509—511.
05004213 Brun, G.L.; Mallet, V. (1973) Detection of organophosphorus
pesticides by in situ fluoranetry on thin—layer chranatograms.
Journal of Chromatography 80(1):117—123.
91
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Coui aphos
Section Two:
Studies Examined and Judged ‘lb Be
Inappropriate for Use in Developing
the Standard
MRID Citation
05005128 Brun, G.L..; Surette, D.; Mallet, V. (1973) A new method for the
detection of orgarophosphorus pesticides by in situ fluora’netry
on thin-layer chrciuatograms. International Journal of
E viroflmental Analytical Chemistry 3(1) :61—71.
05009310 Burchfield, H.P.; Storrs, E.E. (1975) Analysis for organophosphorus
insecticides and metabolities. Journal of Chranatographic
Science 13(5) :202—211.
05003134 Burke, J.A.; blswade, W. (1966) A gas chranatographic column for
pesticide residue analysis: retention times and response data.
Journal of the Association of Official Analytical Ch nists
49(2) :374—385.
05005125 Burnet, E.M. (1970) Pesticide residues in fat of cattle treated with
backrubbers impregnated with cotinaphos, rnethoxychlor or OUT.
Pestic. Sci. l(2):70—72.
05010348 Carlson, C.A. (1966) Effects of Three Organophosphorus Insecticides
on Imature Hexagenia and Hydropsycle of the Upper MisSiSSippi
River. Transaction of the American Fisheries Society 95(1) :1-5.
05013389 Caserio, G.; Mascherpa, G.; Marubini, E. (1970) ssib1e
applications of Artemia sauna as a test animal for detecting
organophosphorus pesticides in meat. Archicio Veterinario
Italiano. Italian Archives of Veterinary f dicine 21(1):49—61.
00005163 Cheinagro Corporation (1962) Paper Chranatographic I su1ts in Co-
Ral. (Unpublished study including letter dated Nov. 21, 1962
fran D. MacD t a1l to T.H. Harris, received Nov. 26, 1962 under
unknown ac3min. no.; suthtitted by Bayvet, Shawnee Mission, Kans •;
CDL: 124751—A)
00005489 Chemagro Corporation (1963) Chemagro Corporation I sidue Experiment
No. EC—212—62D: I port No. 11358. (Unpublished study received
Feb. 11, 1964 under PP0299; CDL:090319—AA).
00005330 themagro Corporation (1963) theinagro Corporation Residue Experiment
No. KC—201—63D: Report No. 10923. (Unpublished study received
on unknown date under PP0306; CDL:090321—D).
92
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Counaphos
Section Two:
Studies Examined and Judged ‘lb Be
Ina ropriate for Use in Developing
the Standard
MRID Citation
00005448 themagro Corporation (1963) The effect of frozen storage at 0 to
- 10 0 F on Co-Hal residues in milk: Report No. 11164.
(Unpublished study received F b. 11, 1964 under PP0299;
CIL:090319—Z).
00005341 Chcmagro Corporation (1963) The Effect of Storage at 40 0 F On Co-
Hal Residues in Milk: Report b. 11212. (UrLpublished study
received on unkn n date under 1F0306; CDL:092586—F).
00005162 themagro Corporation (1964) themagro Corporation Analytical Method:
Determination of DIYr in Co—Hal 25% Wettable sder by
Dehydrohalogenation. Method Th C—2.33 dated Mar. 3, 1964.
(Unpublished study received Mar. 3, 1964 under 11556—21;
suthu.tted by Bayvet, Shawnee Mission, Kans.; CDL:124851—A).
00005836 Chemagro Corporation (1965) Recovery o Co-Ral frciu milk: Report
No. 16197. (Unpublished study received Aug. 18, 1966 under
7F0612; CDL 1 :090796—M).
00005337 Chemagro Corporation (1966) Chemagro Corporation Residue Experiment
No. KC—200-67D: Report No. 19234. (Unpublished study including
report nos. 19235 and 19351, received on unkn n date under
PP0306; CDL:090321—V).
00005046 themagro Corporation (1966) Recovery of Co-Ral fran milk: Report
No. 19235. (Unpublished study received Dec. 15, 1967 under
115546-19; sukxnitted by Bayvet, Shawnee Mission, Kans.;
CDL:014008—C).
00005436 Chemagro Corporation (1967?) Reasonable grounds in su ort of the
petition: Co .inaphos. (Unpublished study received Dec. 21, 1967
under 8F0678; CD [ :092983—C).
00005041 themagro Corporation (1971) Recovery of Co—Pal from Swine: Report
No. 30330. (Unpublished study received Oct. 29, 1971 under 11556—
4; sukinitted by Bayvet, Shawnee Mission, Kans.; CDL:010122—E).
05004292 Clear, M,H; Fowler, F.R.; Solly, S.R.B.; Ritchie, A.R. (1977)
Detection of organorphosphorus and carbamate pesticides in
adipose tissue by thin-layer and gas-liquid chranatgraphy. New
Zealand Journal of Science 20(2):221—224,
93
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Counaphos
Section Two:
Studies Examined and Judged ‘lb Be
Inappropriate for Use in Developing
the Standard
MRID Citation
05004068 Coppage, D.L., Braidich, TE. (1976) River Pollution and
Anticholinesterase Pqents. Water Research 10(l):19—24.
00021983 tale, L.B. (1968). Co—Ral. (Unpublished study received ( tober 8,
1968, under unknown administrative number; suI nitted by tbbay
Chemical Corp., Kansas City, Mo.; CDL:006897—E).
00005487 Ditman, L. P. (1962) Chemagro Corporation Residue Experiment b. EC—
2l2-62H: Report 9912a. (Unpublished study received Feb.
11, 1964 under PP0299; prepared by Univ. of Maryland, Dept. of
& tcinology, Insecticide Laboratory, sukxnitted by themagro Corp.,
Kansas City, Mo.; CDL:090319—Y).
00005107 DDrko, N.M. (1964). Co—Ral E.C. 1 lb/gal Cattle ‘lbxicity Trial:
Report b&. 13684. (Unpublished study received August 24, 1964,
under 11556-23; prepared by themagro Corp., su}xtitted by Bayvet,
Shawnee Mission, Kans.; CDL:007104—S).
00005335 n u11, J. and Root, M. (1966), Effect of Co—Ral in the Diet on the
Blood Cholinesterase Activity of Male and Female Degs: Report
. 18726. (Unpublished study received on unknown date under
PP0306; prepared by University of Chicago, ‘lbxicity Laboratory,
sukxnitted by Chemagro Corp., Kansas City, Mo.; CDL:090321—Q).
00005147 D)u11, J., Root, M., and Cowan, J. (1962). Ninety—Lay Feeding
Studies with Co—Ral in Male and Female Rats and DDgs Fed a Milk
Diet: Report ib. 10200. (Unpublished study received March 11,
1963, under unknown administration number; prepared by University
of Chicago, Department of Pharmacology; sutinitted by Bayvet,
Shawnee Mission, Kans.; CDL:l09146—C),
94
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO I8 Counaphos
Section Two:
Studies E caxnined and Judged To Be
Inappropriate for Use in t ve1oping
the Standard
MRID Citation
00005462 IliBois, K.P. (1958). The I) rma1 Toxicity of Co—Ral and Piperonyl
Butoxide Given Simultaneoously [ sic] to Rats: Report No. 2635.
(Unpublished study received February 14, 1961, under PP0299;
prepared by University of Chicago, D partinent of Pharmacology,
sutinitted by themagro Corp., Kansas City, Mo.; CDL:090320-C).
00005382 IliBois, K.P. (1958). The 1 rma1 Toxicity of Co—Ral (Bayer 21/199)
to Rats: Report No. 2452. (Unpublished study received October 8,
1959, under 1F0306, prepared by University of Chicago, D partment
of Pharmacology, suk nitted by themagro Corp., Kansas City, Mo.;
CDL: 090325—ti)
00005146 DiBois, KP. (1962). Comparison of the Toxicity of Co—Ral to Normal
and Partially Hepatectanized Female Rats: Report No. 10116.
(Unpublished study received March 11, 1963, under unknc n
administration nunber; prepared by University of Chicago,
fl partznent of Pharmacology, sifriitted by Bayvet, Shawnee Mission,
Kans.; CDL:109146—B).
00005507 DiBois, K.P. and Raymund, A. B. (1961). The licute Ibxicity of Bayer
39007 and Bayer 37344 in Catbination with Sane Other
Anticholinesterase Insecticides to Rats: Report No. 7879.
(Unpublished study received June 10, 1964, under 3125—148;
prepared by University of Chicago, L partment of Pharmacology,
su)initted by Mobay Chemical Corp., qricu1tura1 Division, Kansas
City, tb.; CDL:050503—A).
05008663 thing, W. (1967) N w spray reagents for the selective thin—layer
chranatographic determination of pesticides containing nitrogen
groups. Chimia 21(3):132—133.
05006314 Eschle, James L., O h1ein, D.D., Hogan, B.F., and Ivey, M.C.
Counaphos on cable type backrubbers: control of horn flies and
determination of residues in milk of dairy cattle. Jour.
Econanic Entonology, Vol. 66, No. 1, 290—291.
05008484 FN) rking party of experts on pesticide residues. 1975.
05013961 Faulkner, t..C., Carroll, E.J., and Benjamin, M. (1964). Effect of
counaphos on bulls. J. Mt. Vet. Med. Assoc. 145(5):456—459.
95
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Office of Pesticide PrograiT s
Registration Standard Bibliography
Case GSOO18 Cou iaphos
Section Two:
Studies Examined and Judged ‘BD Be
Inappropriate for Use in Developing
the Standard
MRID Citation
05008680 Ferrari, A. (1972) Pesticide residues occurring in animal meats.
Clinical Veterinary Science 95(5):143—152.
05004478 Galley, D.J. (1972) Persistence of Some Organophosphorus
Insecticides in Henhouse Litter. Pesticide Science 3(1):1l9—123.
05002142 Getz, M.E. (1963) The determination of organophosphate pesticides
and their residue by paper chranatography. Pages 9-25, “In”
Residue Reviews: Residues of Pesticides and Other Foreign
Chemicals in F ods arid Feeds. Vol. 2. Edited by F.A. Gunther.
New York: Springer.
05004085 Copal, T., Oehme, F.W. and St. Qiicr, V. (1976). Influence of
dietary protein on the effect of counaphos and trifluprçinazine
interaction in sheep. Pm. J. Vet. Res. 37(10):1143—1152.
05016223 Grechka, G.A. (1973). [ Functional activity of the adrenal cortex of
calves treated with Co-Ral and Sevin suspensions.] Trudy
Stavropol’ Skogo Sel’skokhozyaistvennogo Institue V (XXXVI):181—
184. (Translated from Russian).
05016224 Grechka, G.A. (1973). [ Investigation of the influence of Co—Pal and
Sevin on the cholesterol level in the blood of cattle.] Trudy
Stavropol’ Skogo Sel’skokhozyaistvennogo Institue V (XXXVI);l85—
188. (Translated fran Russian).
05006440 G.ilbransen, B., Laws, L., and Connell, J.A. (1977). Effect of
dipping on the growth rate of grazing cattle. Qieensland J.
Agric. Azthn. Sci. 34(l):99—101.
05005506 Haufe, WO., and Thanpson, C.O.M. (1964) Weight changes in cattle on
dry range in relation to chemical treatments for fly control.
Can. J. Anim. Sci. 44(3):272—280.
00005475 blland, L.M., Faulkner, L., MacDzu al1, D., Skaptason, J.S.
(1961). The Effect on Fertility of Spraying Cattle with Co—Pal:
Report tao. 6186. (Unpublished study received February 14, 1961,
under PP0299; prepared by Colorado State University, sutinitted by
themagro Corp., Kansas City, tt.; CDL:090320-AA).
96
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOOI8 Counaphos
Section TWO:
Studies D amined and Judged ¶1%D Be
Inappropriate for Use in Developing
the Standard
MRID Citation
00005034 Huggins, K.G. (1970) Evaluation of Co—Pal 1% dust in shaker cans
forhorn fly control on beef cows and calves. themagro
Corporation Report No. 29511.
05006182 Hunt, L.M., and McCarty, R.T. (1972). Effects of sane
organophorphorus insecticides on vitamin E and other blood
constituents and on the apparent inducement of diarrhea in
neonatal calves. Bull. iviron. Contain. ‘Ibxicol. 8(5):297—305.
00005083 Industrial Bio— st Laboratories (1974) Recovery of (R) Co—Pal fran
beef fat: Report No. 40706. (Unpublished study received June
20, 1974 under 11556—21; prepared for Baychem Corp., sutinitted by
Bayvet, Shawnee Mission, Kans.; CDL:009815—B).
00005470 Jackson, J,B., Druniond, R.O., Buck,W.B., and Hunt, L.M. (1960).
lbxicity of organic phosphorus insecticides to horses. J.
Econ. taiol. 53(4):602—604. (Report No. 5937; also in
unpublished sutinission received February 14, 1961, under PP0299;
sutinitted by themagro Corp., Kansas City, Missouri; CDL: 090320V).
05004303 Kadin, M. (1960). Systemic effects of Co—Pal and coralox: Q
ocular instillation in the rabbit, dog and hunan. 11fl. J.
hthalImD1. 59(4): 622—627.
05004483 Kaplanis, J.N., Lbpkins, D.E.., and Treiber, G.H. (1959). Derifial
and oral treatments of cattle with phosphorus-32-labeled Co-Pal.
J. 1 gric. Ebod them. 7(7):483—486.
05005516 Katz, M. (1961) Acute ‘Ibxicity of Sane Organic Insecticides to Three
Species of Salnonids and the Threespine Stickleback.
Transaction of the l merican Fisheries Society 90:264—268.
05011426 than, M.A., Kramer, T., and Avery, R.J. (1961). Organophosphate
poisoning in cattle with particular reference to Co-Pal.
Can. Vet. J. 2(6):207—211.
05005518 Khan, M.A., and Lawson, J.E. (1965). Suniner treatments for
cattle grub control and their effects on horn flies and
cattle ight gains. Can. J. AnIm. Sci. 45(1):43—50.
05013391 Knapp, F.W., and Krause, G.F. (1960). Control of the northern
fowl mite, Ornithonyssus sylviarurri (C— and F—), with Rennel,
Bayer L13/59 and Bayer 21/199. J • Econ • E itaio1 • 53(1): 4—5.
97
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOOI8 Counaphos
Section Two:
Studies Examined and Judged ‘ lb Be
Inappropriate for Use in Developing
the Standard
MRID Citation
05008682 Korolev, A.A., Skigan, S.A., Vitsitskaya, B.R., and Sechenov,
I.M. (1972). [ The effect of ozonatian on the anticholinester—
ase activity of several organophosphorus pesticides.] Gig.
Sanit. 37(8):99—10l (Translated from Russian).
05004555 Kreitzer, J.F.; Spann, J.W. (1963) Tests of Pesticidal Synergi n
with Young Pheasants and Japanese Quail. Bulletin of
Environmental Contamination and ‘ lbxicology 9(4) : 2! 5256.
05004077 Lin, T., and Drouh, H.W. (1974). Influence of insecticide
exposure on the in vivo and in vitro metabolic activity of rats.
Arch. Environ. Contain. lbxicol. 2(4):364—377.
05005504 Lindquist, v.A., Burns, E.C., Pant, C.P., and DaI n, P.A. (1958).
Fate of 32—labeled Bayer 21/199 in the white rat. J. Econ.
Enta 1. 51(2):204—206.
00005281 MacI)ugall, D. (1960) Supplement to synopsis of metabolic,
analytical, residue, and taste data on Co—Ral (poultry):
Supplement ? b • 1: Report • 4996 • (Unpublished study received
Mar. 18, 1960 under 11556—21; prepared by themagro Corp.,
su initted by Bayvet, Shawnee Mission, Kans,; CDL:101730—B).
00005343 MacI uga1l, D.; Loeffler, W. (1960) Determination of Co—Ral residues
in milk (Recovery I)ita): Report f b. 5572. (Unpublished study
received Mar. 29, 1961 under 1F0306; sutxnitted by themagro Corp.,
Kansas City, fib.; CDL:092586—J).
05004556 Mallet, V.; Brun, G.L. (1974) A rapid and reliable in situ
spectrophotofluoranetric method for the anlaysis of Co-Ral and
Bayrusil in lake and sewage water. Bulletin of Environmental
Contamination and ‘ lbxicology 12(6) :739—744.
05004309 Mallet, V. N.; Volpe, Y. (1978) Degradation of counaphos in
distilled water as a function of pH. Analytica thiinica ta
97(2) :415-418.
05012621 Malone, J.C. (1962). The toxicity of Coroxon/pheno-thiazine
and cx)unaphos/phenothiazine. Res. Vet. Sci. 3(1): 18—33.
98
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Counaphos
Section Two:
Studies E camined and Judged ‘lb Be
Inappropriate for Use in Developing
the Standard
MIUD : itation
05004557 Matthyssc, J.G. (1974) Insecticides Used on Dairy Cattle and Dairy
Brans: ¶lbxicity to Man and Cattle, Hazards to the Consuner and
the Environment. Journal of Milk and Food Technology 37(5) :255-
264.
00005169 McGrath, H.B. (1961). ¶lblerance of Degs to Daily Application of
Co-Pal 1%-Neguvon 2% Pressurized Spray: 1 port b. 7900.
(Unpublished study received January 9, 1962, under 11556—2,
prepared by themagro Corp., sulxiitted by Bayvet, Shawnee
Mission, Kans.; CDL:014015—B).
05012916 Miklovich, N. (1974). Oitbreaks of poisoning caused by a
phosphate ester insecticide of lc , toxicity in dam?stic
animals (couiiaphos). Tieraerztliche. Unschau 29(2) :85—86,
88—89, 92. (Translated fran German).
05012621 Malone, J.C. (1962). The toxicity of Coroxon/pheno-thiazine
05004314 bscioni, A.D., Engel, J.L., and Casida, J.E. (1977). Kynurenine
fonnamidase inhibition as a possible mechani n for certain
teratogenic effects of organophosphorus and methylcarbamate
insecticides in chicken embryos. Biochem. Pharmacol. 26:2251-
2258.
05002567 Mozier, J.O. (1969). advances in cattle ectoparasite control with
a discussion of sane problems related to treatment with systemic
insecticides. 3. 1 m. Vet. Med. Assoc. 154(l0):1206—1213.
05011425/ Mozier, J.O., and Allen, A.D. (1969). ‘Ibxicity Evaluation of
00005167 Co—Pal 0.5 lb/gal flnulsifiable Concentrate: Paport b. 25343.
(Unpublished study received January 23, 1970, under 11556—26;
prepared by themagro Corp., su1x itted by Bayvet, Shawnee Mission,
Kans.; CDL:014012—B).
00005404 Mozier, J. 0. (1964) Evaluation of ttability and odor of Co—Pal—
Neguvon (0.25%—0.5%) pressurized spray: I port lb. 14596.
(Unpublished study received Jan. 18, 1965 under 11556—29;
prepared by themagro Corp., sutinitted by Bayvet, Shawnee Mission,
Kans,; CD1 .i:lO9118—A).
99
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOOI8 Counaphos
Section Two:
Studies Examined and Judged ¶1 Be
Inappropriate for Use in Developing
the Standard
MRID Citation
00005380 Murphy, S.D., and DuBois, K.P. (1958). The Subacute ¶Ibxicity of
Co—Ral (0, 0-d iethyl-0—3--chloro-4-methyl 7 -counarinyl—phos-
phorothioate; Bayer 21/199) to Rats: Report t . 2205. (Un-
published study received March 3, 1958, under 1F0306; prepared
by University of thicago, Department of Pharmacology, submitted
by Chemagro Corp., Kansas City, MO.; CDL:090324-M).
05019241 Nangniot, P. (1964) Determination of traces of phosphoric esters by
oscillatory polarography. nalytica Chimica Acta 31(2):166—174.
05005578 Nelson, D.L., Mezier, 3.0., White, R.G., and Allen, A.D. (1968).
The pharmacological effect of Baymix (coumaphos) on poultry.
Poult. Sci. 47(3):960—962.
05013409 Nepolklonov, A.A.; Metelitsa, V.K. (1970) Bizymic agardiffusion
method for detecting organophosphorus insecticide residues in
products of animal origin. Transactions, All—Union Scientific
Research Institute of Veterinary Sanitation, 1 35:383—390.
05010755/ cbersteiner, E.J., and Sharma, R.P. (1978). Evaluation of cyto—
05019564 toxic responses caused by selected organophosphorus esters
in chick sympathetic ganglia cultures. Can. J. Carp. Med.
42:80—99.
05004865 O’Neill, D.K.; Alexander, A.E. (1965) Physico—chemical studies of
pesticides. IV. Solubilised pesticides. Journal of the
Science of Ftod and k riculture 16(l2):750—759.
05006444 Palmer, J.S. (1963). ‘Ibxicologic effects of dual applications
of Bayer 21/199 and toxaphene on yearling cattle and young
calves. Vet. Med. 58(ll):872—874.
05012210 Palmer, J.S., and Radeleff, R.D. (1963). The toxicologic
effects of dual applications of Bayer 21/199 and an arsenical
solution on cattle and calves. 3. Pm. Vet. Med. Assoc.
143(11) :1208—1210.
05011425 Palmer, J.S., and Danz, J.W. (1964). Iblerance of Brabman cattle
to organic phosphorus insecticides. 3. Am. Vet. Med. Assoc.
144(12) :143—145.
100
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOOJ.8 Couiiaphos
Section Two:
Studies Examined and Judged ‘D Be
Inappropriate for Use in Developing
the Standard
MRID Citation
05005224 Pickering, W.L, and Malone, J.C. (1967). The acute toxicity
of dichioroalkyl aryl phosphates in relation to chemical
structure. Biochem. F’harmacol. 16(7):1183—1194.
05000801 Proctor, N.H., Noscioni, A.D., and Casida, J.E. (1976). thicken
embryo NAD levels lc ered by teratogenic organophosphorus
and methylcarbamate insecticides. Biochem. Pharmacol.
25(7) :757—762.
05009731 Radeleff, R.D. (1969) Asses ent of the safety of drugs as used in
animal feeds. Pages 193—19 5, “In” Evaluation of Drugs for Use
in Animal Feeds. Washington, D.C.: National Academy of
Sciences. (National Research Council Publication Sb. 1679).
00005393 Radeleff, R.D., and &bers, R.H. (1957?) Report of Ibxicological
Studies of Co-Hal (Bayer Canpound 21/199) in Cattle: Report
No. 1952. (Unpublished study received October 8, 1959, under
1F0306; prepared by U.S. Ngricultural Research Service, suixtitted
by themagro Corp., Kansas City, tb.; CDL:090326-B).
00005446 Riehl, L.A. (1959) 0,0-diethyl O-(8—ch1oro-4-methyl—7—cou ariny1)
phosphorothioate (Co-Hal) residues in chickens: Report No.
3869a. (Unpublished study received Mar. 10, 1961 under PP0299;
prepared in cxoperation with Univ. of California--Riverside,
gricultura1 Experiment Station and Citrus Experii nt Station,
Dept. of Ehta o1ogy, sulinitted by themagro Corp., Kansas City,
tb.; CLD:09)337—J).
00005841 fl,bbins, WE., Ibpk i .ns, T.L.; and Darrow, D.L. (1959). Synergistic
acticn of piperonyl butoxide with Bayer 21/199 and its corres-
ponding phosphate in mice. J. Feon. D tai 1. 52:660-663 (Report
No. 4375; also in unpublished suixtission received February 4,
1961, udner PP0299; sul3nitted by themagro Corp., Kansas City,
tb.; CDL:090320—M).
05006417 1 se, E, and Sherman, M. (1960)., The effect of selected insecti-
cides on growth and egg production when adminsitratered rsic)
continuously in the feed. Rult. Sci. 39:1203—1211.
05014459 Is, J.D. (1958). Co—Hal poisoning in a Hereford bull. South-
western Vet. 12(l):66—67.
101
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Co inaphos
Section ‘Iwo:
Studies Examined and Judged ‘lb Be
Inappropriate for Use in Developing
the Standard
MRID Citation
05016568 Sa, L.N. de; Nazario, W. (1967) The chranatography of the pesticide
•sj p 1 • (“l½suntol”) (ester o,O-diethyl—0—30chloro 4—methyl—2-
oxo_2H —l—benzo ?rone—7—ilphoSPhothiOate) in veterinary
toxicology. Review of the Faculty of Pharmacy and Biochemistry
of the University of Sao Paulo, 5(2):485—491.
00020560 Schafer, E.W. (1972) The Acute Oral ‘Ibxicity of 369 Pesticidal,
Pharmaceutical, and Other Chemicals to Wild Birds. ¶Ibxicology
and Applied Pharmacology 21(?):315—330.
00006794 Scott, W.J., and Beliles, R.P. (1965). Phosalone: Lk)tentiation
Studies in the Rat with Marketed Pesticides. (Unpublished
study received December 15, 1966, under 7G0575; prepared by
*xx3ard Research Corp., suI itted by thiçman Chemical Co.,
Inc . ., Burlingame, Calif., CDL:090729—I).
05001015 Shafik, M.T., et. a!. (1971) A Method for Confirmation of
Organophosphorus Canpounds at the Residue Level. Bulletin of
Environn nta1 Contamination and ¶ibxicology 6(1) :55—56. —
05016445 Shaw, F.R., nith, C.T., Anderson, D.L., Fischang, W.J.,
Ziener, W.H., and Hurny, J. (1964). The effects of counaphos on
poultry and its residues in tissues and eggs. .3. Econ. & taio1.
57 (4 ) : 516—518
00007191 Sherman, II. (1967). Acute Oral Potentiation Studies with S—
Methyl-N-- ((methylcarbanoyl)oxyl thioacetimidate [ INX-1179).
Haskell Laboratory Report . 160-67. (Unpublished study
received on unknown date under 352—342; sulzttitted by E.I.
DePont de mours and Co., Wilmington, Del.; CDL: 0504 28—D).
05004687 Sherman, M., and Ross, E. (1961). Acute and subacute toxicity
of insecticides to chicks. ‘lbxicol. Appi. Pharmacol.
3 :521—533.
05005123 Silvestri, R., Himes, J.A., and Edds, G.T. (1975). Repeated
oral administration of couriaphos in sheep: Effects on
erythrocyte acetyicholinesterase and other constituents.
Am. J. Vet. Res, 36(3):283—287.
102
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Counaphos
Section Two:
Studios Examined and Judged ‘lb Be
Inappropriate for Use in Developing
the Standard
MRID Citation
00005211 Skaptason, J.S., and MacDeugall, D. (1960). Co—Ral——A D g
‘Iblerance Study: Report No. 5133. (Unpublished study
received April 22, 1960, under 11556-12; prepared by
Chemagro Corp., sutinitted by Bayvet, Shawnee Mission,
Kans.; CDL:109077—B).
00005086 Skaptason, J.S. (1960). The Devleoçinent of Co—Ral Aerosol for Use
of Degs. Report No. 6085. (Unpublished study received April
25, 1961 under 11556—22; prepared by themagro Corp., suk ittitted
by Bayvet, Shawnee Mission, Kans.; CDL:014009—A).
00005277 Stauffer Chemical C pany (19??) Storage stability of veterinary
formulations. (Unpublished study received Mar. 13, 1962 under
unknown admin. no.; CDL:121480—C).
05005617 Stijve, T.; Cardinale, E. (1971) Esterase inhibition technique for
the detection of organophorphorus pesticides on thin-layer
chranatograms. Mitteilungen aus dem Gebiete der
Lebebsrnittleluntersuchung und Hygiene 62(1):25—31.
00005215 U.S. Fish and Wildlife Service, Fish Control Laboratory (19??)
Survival of Fishes at 12C. in Nenty—four Hours: Report No.
12947.
00013539 U.S. Fish and Wildlife Service (19??) Pesticide—Wildlife Studies,
1963: A Review of Fish and Wildlife Service Investigations during
the Calendar Year. U.S. Dept. of the Interior Circular 199, .
24, 26, 28.
00005388 Vaughn, G., Deininger, E., and Deull, J. (1958). Effect of Diets
Containing Co-Ral and Malathion on the Blood Cholinesterase
Activity of lbgs: Report No. 2618. (Unpublished study
received October 8, 1959, under 1F0306; prepared by University
of Chicago, Department of Pharmacology, subnitted by themagro
Corp., Kansas City, rb.; CDL:090325—S).
00005160 Vaughn, G., Deininger, E., and Deull, J. (1958). The Subacute
‘ lbxicity of 3-thloro-4-methyl uthelliferone to Rats: Report
? o. 2660a. (Unpublished study received August 11, 1959, under
11556—21; prepared by University of Chicago, Department of
Pharmacology, subuitted by Bayvet, Shawnee Mission, Kans.;
CDt :l00066—A).
1It 3
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Coumaphos
Section Two:
Studies Examined and Judged lb Be
Inappropriate for Use in Developing
the Standard
MRID Citation
00005148 Vesselinovitch, D., Fitch, F., Meskauskas, J., and D ,u1l, J. (1962).
Gross and ijistopathologic Cbservations in the Tissues of the
Offspring of Mice Fed Diets Containing Co-Pal: Report No. 10204.
(Unpublished study received March 11, 1963, under unknown
administration nunber; prepared by University of Chicago, Depart-
ments of Pathology and Pharmacology, subnitted by Bayvet, Shawnee
Mission, Kans.; CDL:109146—E).
00005150 Vesselinovitch, D., Fitch, F.W., Meskauskas, J., and Deull, 3.
(1963). Gross and Histopathologic Observations in the Tissues
of Rats Fed a Milk Diet Containing Co—Pal for Ninety Deys:
Report tb. 10606. (Unpublished study received March 11, 1963,
under unknown administration number; prepared by University
of Chicago, Departments of Pathology and Phannacology; submitted
by Bayvet, Shawnee Mission, Kans.; CDL:109146—F).
05017904 Villeneuve, D.C. (1971) A review of enzymatic techniques for
pesticide residue analysis. Pages 27—38, “In” Pesticides
Identification at the Residue Level. Washington, D.C.: f erican
Chemical Society Publications. (1 3vances in chemistry series
no. 104).
05012896 Washuettl, J. (1974) Pesticides in milk and milk products. Wiener
Tieraerztliche Monatsschrift 61(2) :44—51.
05008665 Weilborn, T.L., Jr. (1971) lbxicity of Some Compounds to Striped
Bass Fingerlings. Progressive Fish — Culturist 33(1):32—36.
00005130 White, R.G., and Allen, S.D. (1964). The Effects of lbpical
1 pp1ication of Co-Ral, Malathion, and Sevin on Laying Hens
Being Fed a Ration Containing Co-Pal: Report No. 15146.
(Unpublished study received July 2, 1968, under unknown
administration number; prepared by themagro Corp., submitted
by Bayvet, Shawnee Mission, Kans.; CDL:221922—F).
00005406 White, R.G., t’bzier, 3.0., and Mullee, M.T. (1964). Evaluation
of Co-Ral—Neguvon (0.25%—05%) Pressurized Spray for lbxicity
and Effctiveness on Cats: I port tb. 15083. (Unpublished
study received June 23, 1965, under 11556-29; prepared by
themagro Corp., submitted by Bayvet, Shawnee Mision, Kans •;
CDL:l00 161—B).
104
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO I8 Coiinaphos
Section Two:
Studies Examined and Judged ‘lb Be
Inappropriate for Use in Developing
the Standard
MRID Citation
00005495 Williams, H.A. (1962). ¶lbxicity Differences in Calves Sprayed
with 0.75% Co—Ral and 0.75% Co—Ral plus 0.5%, 1%, 2%, or 4%
Sulfo TEPP: Report tb. 10023. (Unpublished study received
January 14, 1963, under 11556-21; prepared by Chemagro Corp.,
su1 iiitted by Bayvet, Shawnee Mission, Kans.; CDL:230468—A).
00013554 Witherup, S., and Schiect, H. (1963). The Ininediate Ibxicity
of Vapona, Ciodrin, and Bidrin in Various Co thinations with
Other Organophosphorous Insecticides. (Unpubi shed study
received April 16, 1965, under 5H].748; prepared by Univer-
sity of Cincinnati, Department of Preventive Medicine and
Industrial Health, Kettering Laboratory, sulinit ted by
Shell Chemical Co., Washington, DC; CDL:221616—L).
00005334 lvin, A.A. (1966). Report to Chemagro Corporation: Three
Generation Reproduction Study on Co-Ral white Leghorn
thickens: Report 1 b. 17838. (Unpublished study received
on unknown date under PP0306; prepared by Industrial BiO—
¶I st Laboratories, Inc., suk itted by themagro Corp., KansaS
City, t’b.; CDL:090321—P).
05005121 Wright, F.C., Hunt, L.M., and Palmer, J.S. (1966). The biOchefliCal
effects of counaphos and three oxixnes on certain enz ne systems
and blood protein elements in cattle. Pin. 3. Vet. Res. 27:177
185.
05004051 Younger, R.L., and Wright, F.C. (1971). Acute CounaphoS tOXiCOSiS
in cattle: Antidotal therapy with pralidox xne chloride and
atropine, and related alterations of blood and serun enzymatic
activities. Am. J. Vet. Res. 32:1053—1063.
05004281 Zweig, G.; Devine, J.M. (1969) Determination of organophOsphOruS
pesticides in water. Pages 17-36, “In” Residue Reviews. k)1.
26. New York; Springer.
105
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Co inaphos
Section Three:
Standard Reference Material Used
in .Support of this Standard
MRID Citation
GS0020024 Bontoyan, W., ed. (1976) Manual of Chemical Methods for Pesticide
and t vices. U.S. Environmental Protection 1 gency, Office of
Pesticide Programs, ¶I chnical Services Division, Chemical and
Biological Investigations Branch. (Available fran Association of
Official Analytical Chemists, Arlington, VA).
005000301 Cutting, W.C. (1967) Insecticides, repellents and rodenticides.
Pages l32-140d, “In” Handbook of Pharmacology, 3rd Edition. New
York: Appleton—Century—Crofts.
005005417 tuvidson, L.M.; Feairs, R.H. (1966) Applied insect control:
chemical. Pages 72—100, “In” Insect Pests of Farm, Garden and
Orchard. 6th ed. New York: John Wiley.
005007048 Fairchild, E.J., ed. (1977) ricu1tura1 chemicals and Pesticides: A
Subfile of the NIC H Registry of ¶Ibxic Effects of chemical
Substances. Cincinnati, Ctzio: National Institute for
Occupational Safety and Health. (Pagination includes 46 pages
numbered i—xlvi; available from: NI’IS, Springfield, VA: P6—274
748).
GSOOI8006 Farm Chemicals Handbook (1979). Mister Publishing Co., Willoughly,
O.H. 44094
005010941 Martin, II.; Miles, J.R.W. (1953) Guide to the chemicals Used in Crop
Protection, 2r ed. Ottawa, C itario, Canada: Canads tupartment
of ricu1tura1.
GSOOI8007 Pesticide Chemical Use Pattern Profile for Counaphos. USEPA Office
of Pesticide Prograii s, Benefits arid Field Studies Division,
August 1979 (26A—0052c).
GS0018005 Schutte, W.D., Preliminary ( 1antitative Usage Analyses of Counaphos
(1980) Econanic Analysis Branch, Benefits and Field Studies
Division, Office of Pesticide Programs, U.S. E) ivironmental
Protection 1 ency.
106
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOO18 Counaphos
Section Four:
Studies Identified ‘ibo Late
to be Included in the Standard
MRID Citation
GS0018012 A kins, T.R. (1961) Co—Hal Residues in Cattle Tissues. Bayvet
Division, Cutter Laboratories, Inc. Report No. 7346. EPA CDL
accession ruther 102334? Originally submitted 10/17/61.
GS0018013 Anderson, C.A. (1959) Co—Hal Residues in Chicken B3gs. Bayvet
Division, Cutter Laboratories, Inc. Report No. 3712. EPA CDL
accession number 102332? Orginally submitted 12/11/59.
GS0018014 Anderson, C.A. (1959) Co—Hal Residues in Sheep Tissues. Bayvet
Division, Cutter Laboratories, Inc. Report No. 3665. EPA CDL
accession number 090326. Orginally submitted 10/12/59.
GS0018015 Anderson, C.A. (1960) Co—Hal Residues in Milk. Bayvet Division,
Cutter Laboratories, Inc. Report No. 5533. EPA CDL accession
number 102327? Orginally submitted 9/28/60.
GS0018016 Anderson, C.A. (1961) Co—Hal Residues in Calf (Tissues). Bayvet
Division, Cutter Laboratories, Inc. Report No. 7263. EPA CDL,
accession number 102334? Orginally submitted 10/17/61.
GS0018008 Bayvet Div., Cutter J bs 1 Inc. (E cember 1979) Ibxicology and
Metabolism Co-Hal (cc ,Lllaphos) Fl able Cattle Insecticide
(Bay Vb 9328 Flowablo). EPA accession No. 241573. This
contains 22 individual reports of studies conducted by or for
Bayvet, Cutter or Mobay, in support of the registration
application for Bay Vb 9328 Flowable.
GS0018017 Booth, A. et al. (1958) Urinary Metabolites of Couflarin and 0-
Counaric Acid. Bayvet Division, Cutter Laboratories, Inc.
Report No. 3714. EPA CDL accession number 090320. Originally
submitted 2/20/61.
GS0018018 Burns, J.J ., et. al. (1952) The Isolation and Characterization of a
Metabolic Product of 3,3 ‘—Carboxymethylene—bis- ( 4-h roxy—
counarin) Ethyl Ester Tranexan) fran Human Urine. Bayvet
Division, Cutter Laboratories, Inc. Report No. 6196. EPA CDL
accession number 090320. Originally submitted 3/20/61.
GS0018019 th nagro Corporation (1963) Recovery of Chiorferron fran Milk.
Bayvt Division, Cutter Laboratories, Inc. Report No. 10673. EPA
CDL accession nt.uther 090321. Originally submitted 3/13/61.
107
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOOI8 Counaphos
Section Four:
Studies Identified ‘lt)O Late
to be Included in the Standard
MRID Citation
GS0018020 Chemagro Corporation (1964) Co—Ral Chiorferron Residues in Cattle
Tissues. Bayvet Division, Cutter Laboratories, Inc. Report
No. 13,912. EPA CbL accession number 102335. Originally
sutznitted 8/17/64.
GS0018021 Chemagro Corporation (1964) Co—Ral and Chiorferron Residues in
Cattle Tissues. Cutter Laboratories, Inc. Report No. 13913.
EPA CDL accession number unknown. Originally su}znitted 8/17/64.
GS0018022 themagro Corporation (1966) Trichlorfon Residues in Cattle Tissues
— Other Chemicals Used--Co—Hal. Bayvet Division, Cutter
Laboratories, Inc. Report No. 18495. EPA CDL accession number
006072? Originally sulndtted 9/8/66.
GS0018023 themagro Corporation (1966) Trichiorfon Residues in Milk, Other
Chemicals Used—--Co—Ral. Bayvet Division, Cutter Laboratories,
Inc. Report No. 17970. EPA CDL accession number 006072?
Originally subnitted 9/8/66.
GS0018024 Chemagro Corporation (1967) Co—Ral and Chiorferron Residues in
Milk. Bayvet Division, Cutter Laboratories, Inc. Report No.
20651. EPA CDL accession number unknown. Originally sulxdtted
7/20/67.
GS0018025 Chemagro Corporation (1967) Co-Ral and Chlorferron Residues in
Milk. Bayvet Division, Cutter Laboratories, Inc. Report No.
20663. EPA CDL accession number unknown. Originally sthnitted
7/20/67.
GS0018026 Chemagro Corporation (1967) Co—Hal aix ] Chiorferron Residues in
Milk. Bayvet Division, Cutter Laboratories, Inc. Report No.
20677. EPA CDL accession number unknown. Originally sui iitted
7/20/67.
CS0018027 CheTnagro Corporation (1967) Co-Hal Residues in Milk. Bayvet
Division, Cutter Laboratories, Inc. Report No. 21110. EPA CDL
accession number 006072. Originally suk nitted 1/2/68.
108
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Office of Pesticide Programs
Registration Standard Bibliography
Case GSOOI8 Counaphos
Section Four:
Studies Identified ‘Ibo Late
to be Included in the Standard
MRID Citation
GS0018028 chemagro Corporation (1967) Trichlorfon Residues in Milk. Other
Chemicals Used-—Co--Pal and Fenthion. Bayvet Division, Cutter
Laboratories, Inc. Report No. 21289. EPA CDL accession number
006072? Originally submitted 9/8/66.
GS0018029 Chemagro Corporation (1968) Co—Pal Residues in Bggs. Bayvet
Division, Cutter Laboratories, Inc. Report No. 22809. EPA CDL
accession nuther unknown. Originally submitted 7/15/6 8.
GS0018030 Chemagro Corporation (1968) Co-Pal Residues in Bgs. Bayvet
Divisin, Cutter Laboratories, Inc. Report ND. 22810. EPA CDL
accession number unknown. Originally submitted 7/15/68.
GSOO.L8031 Chemagro Corporation (1968) Co—Pal Residues in E)ggs. Bayvet
Division, Cutter Laboratories, Inc. Report No. 22811. EPA CDL
accession number unknown. Originally submitted 7/15/68.
GS0018032 Dahm, P.A. (1960) Co—Pal Residues in Milk. Bayvet Division,
Cutter Laboratories, Inc. Report lb. 5515. EPA CDL accession
number 102327? Originally submitted 9/28/60.
GS0018033 Drough, H.W. and Arthur, B.W. (1960) Distribution, Excretion, and
Solubility Properties of P—32 Phosphoric Acid Fed to Laying
Hens. Bayvet Division, Cutter Laboratories, Inc. Report ND.
5226. EPA CDL accession number 090320. Orginally submitted
2/20/61.
GS0018034 aiBois, K.P. and Plazak, G. (1959) Studies on the ¶Dxicity and
Anticholinesterase Action of the Oxygen Analogue of Có-Ral.
Bayvet Division Cutter Laboratories, Inc. Report ND. 3922. EPA
CDL accession number 090325. Originally submitted 4/21/60.
GS0018035 aiBois, K.P. and Schmalgemeier, D. (1959) The 1 bsence of Acute
ltxicity of thiorferron to Rats. Bayvet Division, Cutter
Laboratories, Inc. Report lb. 3555. CAP CDL accession number
090325. Originally submitted 4/21/60.
GS0018036 Helms, H. (1962) Co—Ral Residues in Swine Tissues. Bayvet
Division, Cutter Laboratories, Inc. Report No. 9883. EPA CDL
accession number 090319. Originally submitted 12/21/67.
109
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