Internal Report
GENETIC ACTIVITY PROFILES
OF
SUPERFUND PRIORITY 1 CHEMICALS
Michael D. Waters, Ph.D., Director
Genetic Toxicology Division, Health Effects Research Laboratory,
U.S. Environmental Protection Agency, Research Triangle Park, NC 27711
and
H. Frank Stack and Ann L. Brady
Environmental Health Research and Testing, In-
Research Triangle Park, NC 27709
July 9, 1987
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Internal Report
GENETIC ACTIVITY PROFILES
OF
SOPERFUND PRIORITY 1 CHEMICALS
Michael D. Waters, Ph.D., Director
Genetic Toxicology Division, Health Effects Research Laboratory,
U.S. Environmental Protection Agency, -Research Triangle Park, NC 27711
and
H. Frank Stack and Ann L. Brady
Environmental Health Research and Testing, Inc.
Research Triangle Park, NC 27709
July 9, 1987
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Introduction to the Data Base
There are currently more than 200 test systems or bioassays for evaluating
agents that induce genetic or related effects. The number of chemicals for
which data exist is greater than 18,200, with more than 60,000 references in
the data base at the Environmental Mutagen, Carcinogen, and Teratogén
Information Program (EMCT), Oak Ridge National Laboratory, Oak Ridge, TN. The
concept of presenting graphically the results from short—term tests originated
from the need to represent the available qualitative and quantitative data in a
standardized format. Garrett etal. (1984) previously described a method for
presenting the data for a given chemical in a bar or line graph (activity
profile) in which test systems (identified by three—letter code words) are
displayed along the x—axis and values corresponding to the doses employed in
the tests are shown on the y—axis. The total data avt.J.lable from short—term
tests for a compound are thus presented in a condensed format that allows rapid
visualization of the type of genetic (or related) effects induced, and facilitates
comparisons among different chemicals.
Genetic activity profiles have been prepared and compared for 24 known
or suspected human carcinogens (Garrett et al., 1984). The U.S. National
Academy of Science has published genetic activity profiles on cyclamate,
cyclohexylamine, and N—hydroxy cyclohexylamine (NAS, 1985). Genetic activity
profiles also have been prepared for six well—known organic solvents (Vainio et
al., 1985), for 65 pesticides (Garrett etal., 1986), and for six putative
non—carcinogens (Waters et al., 1987a).
The International Agency for Research on Cancer (IARC) has employed the
genetic activity profile methodology in evaluating short—term genetic test
data in three of its Monograph Working Group Meetings: An appendix to Vol.
36 on “Allyl and llylic Compounds, Aldehydes, Epoxides and Peroxides”
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describes the “Activity Profiles for Short—Term Tests” and presents the
profiles for 14 chemicals evaluated in Vol. 36 (IARC, 1985a). The method also
was employed in evaluating short—term test data on 19 chemicals for Vol. 39,
“Some chemicals Used in Plasticizers and Elastomers” (IARC, 1985b), and on
14 chemicals for Vol. 41, “Some Halogenated Hydrocarbons and Pesticide Exposures”
(IARC, 1986).
In December 1986, a Working Group was convened at the IARC to summarize
and bring up to date the findings from tests for genetic and related effects
in experimental systems, and from studies of DNA damage, chroinosomal effects
and mutation in humans for 195 compounds that had been evaluated in Volumes
1—42 of the Monographs for which some data on carcinogenicity to humans
were available (cf. , Waters et al., 1987b). The conclusions of this group
were made available to a Working Group that met in March 1987 to evaluate data
on carcinogenicity in humans and experimental animals for some agents. A full
report of the December meeting will be published as Supplement 6 to the IARC
Monographs (IARC, 1987). The proceedings of the March meeting will be published
as Supplement 7 to the Monographs (IARC, 1988).
In preparation for the December meeting references were selected and
activity profiles and corresponding listings of data and references were
assembled by the Genetic Toxicology Division, Health Effects Research Laboratory
(GTD/HERL), and Environmental Health Research and Testing, Inc. (EHRT), Research
Triangle Park, NC.
The data listings and cited references were reviewed before the meeting
by scientists who subsequently participated in the Working Group and who
also prepared draft summaries of the findings and summary tables. During
the meeting, the tabulated material was reviewed and the entries, indicating
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the positivity or negativity of a test result, were verified and agreed upon.
The summaries and summary tables were also reviewed and verified in working
sessions, and approved by the Working Group.
Methodology
A data set, consisting of a discrete number of assays and of the doses
required to produce responses in those assays, is represented in a bar graph
(activity profile). The lines originating on the x—axis represent the assays
plotted in either a phylogenetic or endpoint sequence. Values on the y—axis
are the logarithmically—transformed lowest effective doses (LED) and highest
ineffective doses (HID) tested. The term “dose”, as used in this report, does
not take into consideration length of treatment or exposure and may therefore
be considered synonymous with concentration: the doses or concentrations used
in all in vitro tests were converted to iig/ml, and those for in vivo tests to
mg/kg bw per day as shown in Appendix 1. Because dose units are plotted on a
log scale, differences in molecular weights of compounds do not greatly influence
comparisons of their activity profiles. Methods for the comparative analysis
of the genetic activity profiles are given in Garrett et al. (1984, 1986) and
Waters et al. (1987c).
Profile—line height (the magnitude of each bar) is a function of the
LED or HID, which is associated’ with the characteristics of each individual
test system, such as population size, cell—cycle kinetics and metabolic
competence. Thus, the detection limit of each test system is different, and
across a given activity profile, responses will vary substantially. No
attempt is made to adjust or relate responses in one test system to those of
another.
Line—heights are derived as follows: for negative test results, the
highest dose tested without appreciable toxicity is defined as the HID. If
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there were evidence of extreme toxicity, the next highest dose is used. A
single dose tested with a negative result is considered equivalent to the
HID. Similarly, for positive results, the LED is recorded. If the original
data have been analyzed statistically by the author, the dose recorded is that
at which the response was significant (p<0.O5). If the data were not analyzed
statistically, the dose required to produce an effect is estimated as follows:
when a dose—related positive response is observed with two or more doses, the
lower of the doses is taken as the LED; a single dose resulting in a positive
response is considered equivalent to the LED.
In order to accommodate both positive and negative responses on a
continuous scale, doses are transformed logarithmically so that effective (LED)
and ineffective (HID) doses are represented by positive and negative numbers,
respectively. The logarithmic dose unit (LDUj ) for a given test system i
and chemical j is represented by the expressions:
LDUjj = —1og 10 (dose), for HID values; LDU ( 0
LDUjj = —log 10 (dose X iO ), for LED values; LDU ) 0
These simple relationships define a dose range of 0 to —5 logarithmic units
for ineffective doses (1—100,000 pg/mi or mg/kg bw) and 0 to +8 logarithmic
units for effective doses (100,000—0.001 pg/mi or mg/kg bw). A scale illustrating
the LDU values is shown in Fig. 1. Negative responses at doses less than
1 pg/rn]. (mg/kg bwr) were set equal to 1. Effectively, an LED value ) 100,000
or an HID value I produces an LDU=O; no quantitative information is gained
from such extreme values. Levels of log dose units between 1 and —1 define a
Nzone of uncertainty in which positive results are reported at very high doses
(10,000 and 100,000 pg/mi or mg/kg bw), and negative results are reported at
relatively low dose levels (1 to 10 pg/mi or mg/kg bw).
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During processing of the data file an average of the logarithmic values
of the data subset is calculated and the length of the profile line represents
this average value. All dose values are plotted for each assay regardless
of whether results are positive or negative. Results obtained in the absence
of an exogenous metabolic system are indicated by a bar (—) and those obtained
in the presence of an exogenous metabolic system are indicated by an
upward—directed arrow (A). When all results for a given assay are either
positive or negative, the average of the responses is plotted as a solid line;
when conflicting data are reported for the same assay (i.e., both positive and
negative results) the majority data are shown with a solid line and of the
minority data with a dashed line (drawn to the maximum response). In the few
cases where the numbers of positive and negative results are equal, the solid
line is drawn in the positive direction, and the maximum negative response
is indicated with a dashed line.
Profile lines are identified by three—letter code words representing
the commonly used tests. Code words have been defined by the GENE—TOX Program
of the U.S. Environmental. Protection Agency (Waters, 1979; Waters and Auletta,
1981) for most of the test systems in current use in genetic toxicology.
Codes now have been redefined (Table 1) in a manner that should facilitate
inclusion of additional tests in the future.
Data Base
Data are available on the genetic and related effects of 195 selected
compounds from volumes 1—42 of the IARC Monographs. The results from these
tests are summarized by endpoint for whole mammals, cultured mammalian cells
and nonmaxmualian systems.
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For each agent the data are given in four forms:
(1) Summary : The activity of the agent or exposure at each endpoint
is described, with emphasis given to studies of DNA damage and chromosomal
effects in humans and in vivo studies in animals.
(2) Tabular sInTm%ary : The activity of the agent is indicated by
phylogenetic group (prokaryotes, lower eukaryotes, plants, insects, animal
cells in vitro , human cells in vitro , animals in vivo and humans in vivo )
according to the endpoint or group of endpoints detected (DNA d m ge,
mitotic recombination, gene mutation, sister chromatid exchanges, micronuclei,
chrontosomal aberrations, aneuploidy, dominant lethality, cell transformation
and iithibition of intercellular communication).
(3) Activity profile plot : The activity of the agent in each test
system displayed quantitatively according to phylogenetic or endpoint order.
(4) Activity profile listing : The activity of the agent in each
individual study is given with the dose used and the reference.
The EPA/IARC Supplement 6 data base on short-term tests contains
approximately 7000 entries from 4000 references, providing an evaluated
qualitative and quantitative analysis of test results on 195 compounds. A
complementary carcinogen data base was established by an IARC Working Group
that met in March 1987 to evaluate the data on the carcinogexucity of these
compounds to humans and to animals. These data bases can be used to examine
retrospectively the usefulness of short—term tests for the prediction of
carcinogenicity and the relationship between specific endpoints or assays
and carcinogenicity. Since the data base includes most types of short—term
tests, covering a wide variety of endpoints, and provides information on
doses, it will also be useful for evaluating individual assays, comparing
the sensitivities of different assays and for making other similar analyses.
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Data on 18 of the 25 Superfund Priority 1 Chenticals were previously
assembled by GTD/HERL and peer reviewed by the IARC as described above. The
summary texts and summary tables for these chemicals have been provided by
the IARC in prepublication draft form and are marked “DRAFT - DO NOT CITE
OR QUOTE”. An additional seven chemicals have been similarly researched in
the published open literature. The literature for these seven chemicals has
been abstracted and reviewed in collaboration with EMCT for the Office of
Pesticides and Toxic Substances. Summary texts and summary tables for these
seven chemicals were prepared by GTD/HERL and EHRT.
The list of Superfund Priority 1 Chemicals represented in this document
is shown in Table 2. The remainder of the document consists of summary texts,
tabular summaries, activity profile plots, and activity profile listings for
these chemicals. A list of full citations appears at the end of the document.
These full citations correspond to the short citations shown in the activity
profile listing for each chemical. A list of the 195 chemicals to appear
in IARC Monographs Supplement 6 is shown in Table 3.
The authors wish to assure the accuracy of the information contained in
this document and request that errors or omissions be brought to their attention.
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REFERENCES
Garrett, N.E., H.P. Stack, M.R. Gross and M.D. Waters (1984) An analysis
of the spectra of genetic activity produced by known or suspected human
carcinogens, Mutation Res., 134, 89—111.
Garrett, N.E., H.P. Stack and M.D. Waters (1986) Evaluation of the genetic
activity profiles of 65 pesticides, Mutation Res., 168, 301—325.
IARC (1985a) IARC Monographs on the evaluation of carcinogenic risk of
chemicals to humans, Vol. 36, Some allyl and allylic compounds,
aldehydes, epoxides and peroxides. Appendix: Activity profiles
for short—term tests, International Agency for Research on Cancer,
Lyon, France, pp. 325—346.
IARC (1985b) IARC Monographs on the evaluation of carcinogenic risk of
chemicals to humans, Vol. 39, Some chemicals used in plastics and
elastonters, International Agency for Research on Cancer, Lyon, France.
IARC (1986) IA Monographs on the evaluation of carcinogenic risk of
chemicals to humans, Vol. 41, Some halogenated hydrocarbons and pesticide
exposures, International Agency for Research on Cancer, Lyon, France.
IARC (1987) IARC Monographs on the evaluation of carcinogenic risks to
humans: Genetic and related effects: An update of selected IARC
Monographs from volumes 1 to 42, Supplement 6, International Agency
for Research on Cancer, Lyon, France, in press.
IARC (1988) IARC Monographs on the evaluation of carcinogenic risks to
humans: Carcinogenicity: An update of selected IARC Monographs
frau volumes 1 to 42, Supplement 7, International Agency for Research
on Cancer, Lyon, France, in press.
NAS (1985) Evaluation of cyclamate for carcinogenicity, National Academy
Press, U.S. National Academy of Sciences, Washington, DC, pp. 67—70.
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Vainio, H., M.D. Waters, and H. Norppa (1985) Mutagenicity of selected
organic solvents, Scand. J. Work Environ. Health, 11 (Suppl. 1), 75—82.
Waters, M.D. (1979) The GENE—POX program, in: A.W. Hsie, J.P. O’Neill,
and V.K. McElheny (Eds.), Banbury Report 2, Cold Spring Harbor,
Cold Spring Harbor Laboratory, pp. 449—467.
Waters, M.D., and A. Auletta (1981) The GENE—POX program: Genetic activity
evaluation, 3. chem. Inf. Comput. Sci., 21, 35—38.
Waters, M.D., H.B. Bergman, and S. Nesnow (1987a) The genetic toxicology
of Gene—Pox non—carcinogens, Mutation Res., in press.
Waters, M.D., H.F. Stack, A.L. Brady, P.H.M. Lohman, L. Haroun, and H. Vainio
(198Th) Use of computerized data listings and activity profiles of
genetic and related effects in the review of 195 compounds, Mutation
Res., in press.
Waters, M.D., R.F. Stack, J.R. Rabinowitz and N.E. Garrett (1987c) Genetic
activity profiles and pattern recognition in test battery selection,
Mutation Res.,, in press.
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TABLE 1
TEST SYSTEM CODE WORDS IN ALPHABETICAL ORDER
ACC Alliuin cepa, chromosome aberration
AlA Aneuploidy in animal cells in vitro
AIH Aneuploidy in human cells in vitro
ANF Aspergillus nidulans, forward mutation
ANG Aspergillus nidulans, genetic crossing—over
ANN Aspergillus nidulans, aneuploidy
ANR Aspergi].lus nidulans, reverse iutation
ASM Arabidopsis species, mutation
AVA Aneuploidy in animal cells in vivo
AVH Aneuploidy in human cells in vivo
BHD Binding (covalent) to DNA in humans, in vivo
BHP Binding (covalent) to protein in humans, in vivo
BFA Body fluids from animals, microbial mutagenicity
BFH Body fluids from humans, microbial ‘nut ageni city
BID Binding (covalent) to DNA, in vitro
BIP Binding (covalent) to protein, in vitro
BPF Bacteriophage, forward imitation
BPR Bacteriophage, reverse mutation
3RD DNA repair—deficient bacteria, differential toxicity
BSD Bacillus subtilis rec strains, differential toxicity
BSM Bacillus subtilis multi—gene test
BVD Binding (covalent) to DNA in mammals, in vivo
BVP Binding (covalent) to protein in mammals, in vivo
CBA chromosome aberration in animal bone marrow cells in vivo
CBH Chromosome aberration in human bone marrow cells in vivo
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TABLE 1 (continued)
CCC Chromosome aberration in vivo, spermatocytes treated and observed
CGC Chromosome aberration in vivo, spermatogonia treated, cytes obs.
CGG Chromosome aberration in vivo, spermatogonia treated and observed
CHF Chromosome aberration in human fibroblasts in vitro
CHL Chromosome aberration in human lymphocyte in vitro
CHT Chromosome aberration in transformed human cells in vitro
CIA Chromosome aberration in other animal cells in vitro
dC Chromosome aberration in Chinese hamster cells in vitro
CIH chromosome aberration in other human cells in vitro
dIM Chromosome aberration in mouse cells in vitro
CIR chromosome aberration in rat cells in vitro
CIS Chromosome aberration in Syrian hamster embryo cells in vitro
CIT Chromosome aberration in tumor cells in vitro
LA Chromosome aberration in animal leukocytes in vivo
CLH Chromosome aberration in human lymphocytes in vivo
COE Chromosome aberration in oocytes or embryos in viva
CVA chromosome aberration in other animal cells in vivo
CVH Chromosome aberration in other human cells in vivo
DIA DNA strand breaks, crossl. and rel. damage in animal cells in vitro
DIH DNA strand breaks, crossl. and rel. damage in human cells in vitro
DLM Dominant lethal test in mice
DLR Dominant lethal test in rats
DMC Drosophila melanogaster, chromosome aberration
DMG Drosophila melanogaster, genetic crossing—over and recombination
DUN Drosophila melanogaster, heritable translocation test
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TABLE 1 (continued)
DML Drosophila
DMM Drosophila
DMN Drosophila
DMX Drosophila
DVA DNA strand
DVR DNA strand
ECB
E D Escherichia coli
ECF Escherichia coli,
E K Escherichia coli
E L Eacherichia coil
ECR Escherichia coil,
ECW Escherichia coli
EC2 Escherichia coli
ERD
GCL
GCO Gene
GIA Gene
GIH Gene
GML Gene
GVA Gene
G5T Gene
G51 Gene
G9H Gene
G90 Gene
melanogaster, dominant lethal test
melanogaster, somatic mutation
inei.anogast er, aneuploidy
melanogaster, sex—linked recessive lethal test
breaks, crossi. and rel. damage in animals in vivo
breaks, crossl. and rel. damage in humans in vivo
Escherichia coli (or E. coil DNA) strand breaks, crosslinks or repair
Eacherichia coli
Gene mutation in
pol A/W3110—P3478 spot test, diff. toxicity
forward mutation
X12, mutation
p0]. A/W3110—P3478 liquid susp. test, diff. toxicity
miscellaneous strains., reverse mutation
WP2 uvrA, reverse mutation
WP2, reverse mutation
rec strains, differential toxicity
chinese hamster lung cells in vitro
Chinese hamster ovary cells in vitro
other animal cells in vitro
human cells in vitro
mouse lymphoma cells (excluding L5178Y) in vitro
animal cells in vivo
mouse L5178Y cells in vitro, TX locus
mouse L5178Y cells in vitro, all other loci
chinese hamster lung V—79 cells in vitro, HPRT
Chinese hamster lung V—79 cells in vitro, ouabain
mutation in
mutation in
mutation in
mutation in
mutation in
mutation in
mutation in
mutation in
mutation in
Host mediated assay, animal cells in animal hosts
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TABLE 1 (continued)
HMH Host mediated assay, human cells in animal hosts
HMM Host mediated assay, microbial cells in animal hosts
HSC Hordeum species, chromosome aberration
HSM Hordeum species, mutation
1CM Inhibition of intercellular communication, human in vitro
ICR Inhibition of intercellular communication, rodent in vitro
KPF Kiebsiella pneumonia, forward mutation
MAP Micrococcus aureus, forward mutation
MHT Mouse heritable translocation test
MIA Micronucleus test in human cells in vitro
MIM Micronucleus test in human cells in vitro
MST Mouse spot test
MVA Micronucleus test in other animals in vivo
MVC Micronucleus test in hamsters (cricetulus sp.) in vivo
MVH Micronucleus test in human cells in vivo
MVM Micronucleus test in mice in vivo
MVR Micronucleus test in rats in vivo
NCF Neurospora crassa, forward mutation
NCN Neurospora crassa, aneuploidy
NCR Neurospora crassa, reverse mutation
PLC Plants (other), chromosome aberration
PLI Plants (other), micronuclei
PLM Plants (other), mutation
PLS Plants (other), sister chromatid exchange
PLU Plants, unscheduled DNA synthesis
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TABLE 1 (continued)
PRB Prophage, induction, SOS repair test, DNA strand breaks, or crosslinks
PSC Paramecium species, chromosome aberration
PSM Paramecium species, mutation
RIA DNA repair exclusive of UDS in animal cells in vitro
RIR DNA repair exclusive of UDS in human cells in vitro
RVA DNA repair exclusive of UDS in animal cells in vivo
SAD Salmonella typhimurium, differential toxicity
SAP Salmonella typhimurium, forward mutation
SAL Salmonella typhimurium, all strains
SAO Salmonella typhimurium TA100, reverse mutation
SAS Salmonella typhimurium, mutation, other miscellaneous strains
SA2 Salmonella typhimurium TA1O2, reverse mutation
SA3 Salmonella typhimurium TA1530, reverse mutation
SA4 Salmonella typhimurium TA1O4, reverse mutation
SA5 Salmonella typhimurium TA1535, reverse mutation
SA7 Salmonella typhimurium TA1537, reverse mutation
SAB Salmonella typhimurium TA1538, reverse mutation
SA9 Salmonella typhimurium TA98, reverse mutation
SCF Saccharomyces cerevisiae, forward mutation
SCG Saccharomyces cerevisiae, gene conversion
8CR Saccharomyces cerevisiae, homozygosis by rec. or gene conversion
SCN Saccharomyces cerevisiae, aneuploidy
8CR Saccharomyces cerevisiae, reverse mutation
SGR Streptomyces griseoflavus, reverse mutation
SRF Sister chromatid exchange in human fibroblasts in vitro
SRL Sister chromatid exchange in human lymphocytes in vitro
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TABLE 1 (continued)
SPF
SPH
SPM
SPR
SPs
SSB
SSD
STF
STR
SVA
SVH
S ZD
SzF
SZG
Sister chromatid exchange
Sister chromatid exchange
Sister chromatid exchange
Sister chromatid exchange
Si ster chromatid exchange
Sister chromatid exchange
Sister chromatid exchange
Sister chroinatid exchange
Sister chromatid exchange
Mouse specific locus test,
Mouse specific locus test,
in transformed human cells in vitro
in other animal cells in vitro
in CHO cells in vitro
in other human cells in vitro
in mouse cells in vitro
in rat cells in vitro
in syrian hamster cells in vitro
in transformed cells in vitro
in human lymphocytes in vivo
other stages
post spermat ogoni a
SRT
SIA
SIC
SIH
SIN
SIR
S’S
SIT
SLH
S W
SLP
Sperm morphology, Fl mouse
Sperm morphology, human
Sperm morphology, mouse
Sperm morphology, rat
Sperm morphology, sheep
Saccharomyces species, DNA breaks, crosslinking, and rel. damage
Saccharomyces cerevisiae, DNA repair deficient, diff. toxicity
Streptomyces coelicolor, forward mutation
Streptomyces coelicolor, reverse mutation
Sister chromatid exchange in animal cells in vivo
Sister chromatid exchange in other human cells in vivo
Schizosaccharomyces pombe, DNA repair deficient, diff. toxicity
Schizosaccharomyces pombe, forward mutation
Schizosaccharomyces pombe, gene conversion
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TABLE 1 (continued)
SZR Schizosaccharomyces pombe, reverse mutation
TAM Cell transformation in AKR/ME mouse cells
TBM Cell transformation in BALB/C3T3 mouse cells
TCL Cell transformation in established cell lines
TcM Cell transformation in C3R1OT1/2 mouse cells
TCS Cell transformation in Syrian hamster embryo cells, clonal assay
TEV Cell transformation in viral enhancement
TFS Cell transformation in Syrian hamster embryo cells, focus assay
TIH Cell transformation in human cells in vitro
TPM Cell, transformation in mouse prostate cells
PRR Cell transformation in RLV/FISCHER rat embryo cells
TSC Tradescantia species, chromosome aberration
TSI Tradescantia species, micronuclei
TSM Tradescantia species, mutation
TVI Cell transformation, treat in vivo, score in vitro
T7R Cell transformation in SA7/rat cells
T7S Cell. transformation in SA7/SHE cells
UBH Unscheduled DNA synthesis in human bone marrow cells in vivo
UHF Unscheduled DNA synthesis in human fibroblasts in vitro
UHL Unscheduled DNA synthesis in human lymphocytes in vitro
UHT Unscheduled DNA synthesis in transformed human cells in vitro
UIA Unscheduled DNA synthesis in other animal cells in vitro
UIH Unscheduled DNA synthesis in other human cells in vitro
UPR Unscheduled DNA synthesis in rat primary hepatocytes in vivo
URP Unscheduled DNA synthesis in rat primary hepatocytes in vitro
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TABLE 1 (continued)
t WA Unscheduled DNA synthesis in other animal cells in vivo
UVC Unscheduled DNA synthesis in hamster cells in vivo
UVH Unscheduled DNA synthesis in other human cells in vivo
UVM Unscheduled DNA synthesis in mice in vivo
UVR Unscheduled DNA synthesis in rat cells in vivo
VFC Vicia faba, chromosome aberration
‘IFS Vicia faba, sister chromatid exchange
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TABLE 2 • SUPERFUND PRIORITY 1 CHEMICALS
(Chemicals marked with an asterisk were not reviewed by the IARC)
CHEMICALS CAB NUMBER
1. ALDRIN 309—00—2
2. ARSENIC +3 7440—38—2+3
ARSENIC +5 7440—38—2+5
3. BENZENE 71—43—2
*4 BENZO(A)PYRENE 50—32—8
*5 BENZO(B)FLUORANTHENE 205—99—2
*6. BENZ(A)ANTHRACENE 56—55—3
7. BERYLLIUM 7440—41—7
8. CADMIUM 7440—43—9
9. CHLOROFORM 67-66—3
10. CHROMIUM +3 7440—47—3+3
CHROMIUM +6 7440-47-3+6
11. CHRYSENE 218—01—9
*12. DIBENZO(A,H)ANTHRACENE 53—70—3
13. DICHLOROBENZENE, p.- 106-46—7
14. DICHLOROMETHANE 75-092
15. DIELDRIN 60—57—1
*16. DIETHYLHZXYLPHTHALATE 117-81—7
17. HEPTACHLOR 76—44—8
18. LEAD 7439—92—1
*19 N—NITROSODIPHENYLAMINE 86—30—6
20. NICKEL 7440—02—0
21. POLYCHLORINATED BIPHENYLS 1336—36-3
22. TcDD, 2,3,7,8— 1746—01—6
23. TETRACKLOROETHYLENE 127-18-4
24. TRICHLOROETFIYLENE 79—01—6
25. VINYL CHLORIDE 75—01—4
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TABLE 3. 195 CHEI 1ICALS IN IARC MONOGRAPHS SUPPLEMENT 6
CHEMICALS CAS NUMBER
2,4,5—T 93—76—5
2,4—D 94—75—7
ACROLEIN 107—02—8
A RYLONITRILE 107-13-1
ACTINOMYCIN D 50-76-0
ACETALDEHYDE 75—07-0
ADRIAMYCIN 23214—92—8
AFLATOXIN Bi 1162—65—8
AFLATOXIN G1 1165-39-5
AFLATOXIN M l 6795-23—9
AFLATOXIN 32 7220—81—7
APLATOXIN G2 7241-98-7
ALDR.IN 3 09—00—2
AMITROLE 61—82—5
AMINOBIPHENYL, 4— 92—67—1
ANOSITE ASBESTOS 12172—73—5
ANTHOPHYLLITE ASBESTOS 17068-78-9
ANILINE 62—53—3
ARSENIC +3 7440—38—2+3
ARSENIC +5 7440—38—2+5
ASBESTOS 1332—21—4
ATTAPULGITE 12174-11-7
AURAMINE 492—80—8
AZATHIOPRINE 446-86-6
BCNU 154—93—8
BERYLLIUM 7440—41—7
BENZIDINE 92—87—5
BENZYL CHLORIDE 100—44—7
BENZENE 71—43—2
BENZOTRICHLORIDE 98—07—7
BENZAL CHLORIDE 98-87—3
BENZOYL CHLORIDE 98-88—4
BISCHLOROMETHYL ETHER 542-88-1
BLEOMYCIN 11056—06—7
BUTADIENE, 1,3— 106—99—0
CADMIUM 7440—43—9
CARBON TETRACHLORIDE 56-23-5
CCNtJ 13010—47—4
CHLORMADINONE ACETATE 3 02-22-7
HLORANEUCIL 305-03—3
cHLORNAPHAZINE 494—03—1
CHRYSOIDINE, 0— 532—82—1
CHLORDANE 57-74-9
CHROMIUM +3 7440—47—3+3
CHROMIUM +6 7440—47—3+6
CHLOROMETHYL METHYL ETHER 107-30-2
CHLOROPRENE 126-99-8
CHRYSOTILE ASBESTOS 12001—29—5
CHLOROBIPHENYL, 4— 2051—62-9
CHLORAZ4PHENICOL 56-75-7
CHOLESTEROL 57-88—5
CHLOROFORM 67-66—3
CHLORODIFLUOROMETHANE 75-45-6
CISPLATIN 15663—27—1
CLOFIBRATE 637-07—0
CLOMIPHENE CITRATE 50—41—9
CROCIDOLITE ASBESTOS 12001—28—4
CYCLOPHOSPHANIDE 50-18—0
CYCLOPROPANE 75-19—4
-------
TABLE 3 (continued)
CHEMICALS CAS NUMBER
CYCLOHEXYLA1IINE 108-91-8
CYCLAMATE, SODIUM 13 9—05—9
CYCLAMATE, CALCIUM 139—06-0
DAPSONE 80—08—0
DACARBAZINE 4342—03—4
DDT 8017—34—3
DES DIPROPIONATE 13 0—80—3
DIVINYL ETHER 109-93—3
DIMETHOXYSENZIDINE, 3,3’— 119—90—4
DIRECT BROWN 95 16071—86—6
DIRECT BLACK 38 1937-37-7
DIRECT BLUE 6 2602—46—2
DIAZEPAI4 439—14—5
DI m1LSTILBOESTROL 56-53-1
DIETI1 L rti R 60—29—7
DIELDRIN 60—57—1
DIENOESTROL 84-17—3
DIcHLCROBENZIDINE, 3,3’— 91—94—1
DIBROMO NLOROPROPANE 9 6-12-8
DICYCLCHEXYLAZ4INE 101-83—7
DIcHLOROBENZENE, P— 106—46—7
DIcHLOROPHENOL, 2,4— 120—83—2
DIOXANE, 1,4— 123—91—1
DICELOROPROPENE, 1,3— 542—75—6
DIETZIYL SULPHATE 64—67—5
DIC HLOROMETRANE 75—09—2
DICHLOROPROPANE, 1,2— 75—87—5
DIMETHYL SULPHATE 77-78—1
DIMETHYLCARBANOYL CHLORIDE 79-44-7
DIcHLOROBENZENE, 0- 95-50—1
DIMETHISTERONE 79—64-1
ENPLVRANE 13838—16—9
EPI HLOROHYDRIN 106—89—8
ERIONITE 12510—42—8
ETHYNODIOL DIACETATE 297-76-7
ETHINYLOESTRADIOL 57—63—6
EThYLENE DIBROMIDE 106—93—4
EmILENE OXIDE 75—21-8
Erzi LENEmIOURZA 96—45—7
FLUROXENE 406—90—6
FLUORIDE, SODIUM 7681-49-4
FLUOROURACIL, 5— 51—21—8
FORMALDEHYDE 50—00—0
MALOTHANE 151—67—7
HEXAcHLOROBENZENE 118—74—1
HEXA HLOROCYCLOHEXANE 58-89-9
HEP AcHLOR 76-44-8
HEXOESTROL 84-16—2
HYDRALAZINE 86—54—4
HYDRAZINE 302—01—2
ISOFLURANE 26675—46—7
ISONIAZIDE 54—85—3
ISOPROPYL ALCOHOL 67-63-0
LEAD 7439—92—1
MAGENTA (PARA-ROSANILINE) 569-61-9
MAGENTA (ROSANILINE) 632-99-5
MCPA 94-74-6
MELPHALAN 148—82—3
METHOXYPSORALEN, 8— (+UVR) 298—81—7
METHOXYPSORALEN, 8- (DARK) 298—81—7-+-D
-------
TABLE 3 (continued)
CHEMICALS CAS NUMBER
METRONIDAZOLE 443-48-1
METHOXYPSORALEN, 5- (DARK) 484—20—8+D
METHOXYPSORALEN, 5- (+UVR) 484—20—8
MEDROXYPROGESTERONE ACETATE 7 1-58-9
MESTRANOL 72—33—3
METHOXYFLURANE 76-38-0
MERCAPTOPURINE, 6— 50—44—2
METHOTREXATE 59—05—2
METHYL BROMIDE 74-83—9
METHYL CHLORIDE 74-87—3
MNNG 70—25—7
MOCA 101—14—4
N-PHENYL-2 -NAPHTHALANINE 135-88-6
MUSTARD GAS 505—60—2
MYLERAN 55—98—1
NAPHTHYLAZ4INE, 1— 134-32—7
NAPBTifYLAMINE, 2— 91—59—8
NAPHTHYL T HIOUREA 86-88—4
NITROUS OXIDE 10024—97—2
NITROGEN MUSTARD 51-75-2
NICKEL 7440—02—0
NORETHISTERONE ACETATE 5 1-98-9
NORETHYNODREL 68-23-5
NORGESTREL 797-63—7
OCHRATOXIN A 303-47—9
OESTRIOL 50—27—1
OESTRADIOL, 17B— 50—28—2
OESTRONE 53-16-7
PENTACHLOROPHENOL 87-86-5
PHENELZINE SULPHATE 156-51-4
PHENACETIN 62-44—2
PHENOBARBITAL 50-06—6
PHENYLBUTAZONE 50-33—9
PHENYTOIN 57-41—0
PHENAZOPYRIDINE 136-40—3
POLYCELORINATED BIPHENYLS 1336-36-3
POLYBROMINATED BIPHENYLS 67774-32—7
PROGESTERONE 57-83-0
PROCARBAZINE HCL 366-70-1
PROPYLTHIOURACIL 51-52-5
PREDNISONE 53—03—2
PROPYLENE OXIDE 7 5-56—9
RESERPINE 50—55—5
SACCHARIN, SODIUM 128-44—9
SACCHARIN 81—07—2
SILICA 14808—60—7
SODIUM MONOFLUOROPHOSPHATE 10163-15-2
STANNOUS FLUORIDE 7783—47-3
STYRENE 100-42—5
SULFAMETHOXAZOLE 723-46-6
TALC 14807—96—6
TCDD, 2,3,7,8— 1746—01—6
TETRACBLOROETHYLENE 127-18-4
TETRACHLOROBIPHENYL 35693—99-3
TESTOSTERONE 58-22-0
TETRACHLOROPHENOL, 2,3,4,6- 58—90—2
TETRACHLOROETHANE, 1,1,2,2— 79—34—5
TETRAETHYL LEAD 70—00—2
TETRANETHYL LEAD 75-74-1
THIOTEPA 52-24—4
-------
TABLE 3 (continued)
CH fICALS CAS NUMBER
TOLUIDINE,0— 95—53—4
TOLUENE 2,4—DIISOCYANATE 584-84—9
TOLUENESULPHONA14IDE, 0- 88-19—7
TRIS (2, 3-DIBROMOPROPYL) P04 126-72—7
TREOSULPHAN 299-75—2
TRIMETHYLPSORALEN,4,5’ ,8—(+UV) 3902—71—4
TRIAZIQUONE 68-76-8
TRIMETHYLPSORALEN, 4,5’,8—DABX 3902—71—4+D
TRI HLOR0ETHYLENE 79-01-6
TRIcHLOROPHENOL, 2,4,6— 88—06—2
TRICHLOROPHENOL, 2,4,5— 95—95—4
URACIL MUSTARD 66-75—1
VINBLASTINE SULPHATE 143-67-9
VINCRISTINE SULPHATE 2068-78-2
VINYL CHLORIDE 75-01-4
VINYLIDENE CHLORIDE 75—35—4
IARCS6) >
-------
FIGURE 1
Positive Log Dose
(iig/ml or mg/kg bw) Units
0.001 8
0.01 7
0.1 6
1.0 . . . . . . . . . . . . . 5
10 4
100 3
1000 2
10000 1
100000 . . . . . . 1 0
10 • —1
100 . . . . . . —2
1000
10000 •
100000 . . . . . . —5
Negative
( i g/utl or mg/kg bw)
-------
APPENDIX 1
DOSE CONVERSIONS FOR ACTIVITY PROFILES
Doses are reported in various units and must be converted to pg/mi for non—
mamalian tests or for mammalian in vitro tests. For mammalian in vivo assays,
body fluid assays or host—mediated assays, doses are converted to mg/kg body
weight/day of exposure.
Non Mammalian Tests or Mammalian In Vitro Tests
Some co on dose conversions used in these assays include:
1. Weight per volume converts directly to pg/mi.
2. Molar concentration X molecular weight mg/mi io pg/mi;
mM concentration X molecular weight — pg/mi.
3. Microbial plate tests given as weight per plate are divided by
the top agar volume. If no volume is given, 2 ml top agar is
assumed.
4. Microbial spot tests given as weight or weight/disk are not converted
to weight/volume of the top agar. Concentration varies depending
upon the solubility of the compound. 1 ml volume is assumed as a
rough approximation.
M ,wftalian in vivo tests
Doses obtained from in vivo mammalian tests are converted to mg/kg body
weight/day of exposure assuming 100% absorption and using standard weight
and intake values for each sex and species of rodent, as reported by Gold et
al., 1984. For example, in a test using male mice fed 50 ppm of an agent in
the diet, the standard food intake per day is 12 percent body weight, and the
conversion is:
Dose 50 ppm X 12%
- 6 mg/kg body weight/day.
Standard values used for humans are as follows:
Weight (kg)
Surface
area m 2
Inhalation rate
(L/m.tn)
70
male
1.7
male
20 light work
55
female
1.5
female
30 mild exercise
(male or female)
-------
Assumptions
Certain assumptions must be made in any attempt at standardizing doses because
of physical properties of the compound and the route of exposure. The following
assumptions are based on the physical properties of the tested agents.
1. Soluble solids expressed as % concentration are assumed to be in units of
mass per volume (i.e. 1% 0.01 glut ] . = 10,000 pg/mi. Also, 1 ppm = 1
p glut].).
2. Liquids expressed as % concentration are assumed to be in units of
volume per volume. Convert liquids to weight per volume using the
density CD) of the solution (D glut].). If the bulk of the solution
is water then D = 1.0 g/ut]..
3. Gases and vo].atiles are also assumed to be in units of volume per
volume; however, they must be converted from volume to mass using
the ideal gas law PV = aRT. For exposure at 20 — 37’C at standard
atmospheric pressure 1% (V/V) 0.4 pg/rn]. x molecular weight of the
gas. Also 1 ppm (V/V) — 4 x i0 pg/mi x molecular weight.
The fibrous form of asbestos necessitates a special conversion. In in vitro
tests the concentration of asbestos is coimnonly given in units of pg/cm 2
area of the culture dish, and a conversion from area to volume is necessary.
As an example for a 100 mm dish with an agar volume of 10 ml .,
A — iT x(5cm) 2 78.5 2
and 1 ml. — 785 2.
Assumptions also were made in dose conversions because of the different routes
of exposure, particularly from inhalation of particles. Difficulties are
encountered because of the differences in particle size of different compounds
and the rate of deposition in different areas of the respiratory system.
100% absorption was generally assumed; however, where reported the dose at the
target site was used. For example, in human lymphocyte studies with lead or
pentachlorophenol exposure in vivo, doses are the measured blood concentrations
in pg/mi.
-------
SUPERFUND PRIORITY 1 CHEMICALS :
SUMMARY
TABULAR SUMMARY
*In these tables, the following symbols are used:
+ positive for the endpoint and phylogenetic category
+ positive, but ortiy one valid study
— negative
— negative, but only one valid study
? equivocal or inconclusive
ACTIVITY PROFILE PLOT
a. Endpoint sequence
b. Phylogenetic sequence
ACTIVITY PROFILE LISTING
In phylogenetic order
-------
CRAFT
DO NOT CITE OR QL 1 TE
No data were available on the genetic and related effects of aidrin
in hun ns.
Aidrin did r t induce dominant lethal i :in mice. In sir le
stndies, it induced throitcsoiial aberrati s UT bone—mavr cells of rats
and mice, t*it r t micronuclei in u se:1 iii-tt rr cells iz ivo . It
induced dirazcsxal aberrations in cultured htnr lyn ocyte5 t .rhes
of E dai ge in h n and ‘ alian cells th ‘ atro were inax cluswe.
Aidrin inhibited intercellulac c xu. ucatiai {n bath ht n and rodent
cell system. Aldri.n did rx t ir e t ssive lethal iitations in
it s z gen ic imitagenic to bacteria
and did r t i áka 9 e :of pl: . i
lIA. ::::::::: : : :::::::.
-------
- ----——-—-- —.--———.-———------———-
,j1-ttlf*i.— -,j- ij-it ——-- — —----- --—-- -
& n-m ima1ian ayat
j4aarm IJau ayst ns
— —
— - —
--
Prc a- karyotes
ryc*ea -
—
-
In vivo
-
yot.es
— —
Plants
— — — —
Insect -a
— — —
t1on-wh Iaan
— — 4+i rrt —. pa. —
lunan
— — • — - —
Non-hisn n
— -— — — — —
Hunan
— — — — —
—
D GD
A E
D
3
C
A
D
0
C
A
D
S
H
i
A
T
I
D
S
S
14
C
AT
D
C
S
H
C
A
I L
D
C
S
14
C
&
— — —
1
——
— —
4
-1-
,_.
a. —
_
—
-
—
—
?
.
——
::
&a
::::
SJ
::4
t-
1.
: :.
s
:::
-
r
.::
—
pS.. .
.1
-1’
i
:::
; . —
—
::.
. .
.
4
—
.—
j
4-
—
—
4
..
—
D. W damage; 3, gene ia tatia*; C, d1rai* Qnal aberrations; S. slster chrca idcl:eicchangea; A 1 AU 1oidy, T. cell
tranafotmation. IL. dczninant lethal. H micronuclei, R, mitotic r itinatfrz% or gene Exnversion L inkübition of intercellular
‘catJ :: :::: .
—____
No.
Subrwp -
-------
PLDflIfl g-JUL-e7
30g-OO-2
6-
4-
In
I —
2-
3
uJ
ill
UU S SE U I U
C RH U UC I U L
B Pt 0 92 X
I or 1 o l I R C j1rnian f sc nic I c non. Tiai ( 1 u f CEI. TIWSFO IV TIa1
-------
RLDIRIfl 9-JUL-B?
309-00-2
I I I I I II I
6-
4- —
lfl
E 2-
w - ,- .- —
U i
—4- —
E S SE S U U I S
C A AC I A H U L
I S 12 P 1 I I
Pf C YOT LO R U( 4VOT PU T I CT m VITRO I4I I FM I W1 VI’. I4I ’
n VITRO [ J m vivo
-------
ALDRIN
309-00-2
9-JUL-87 PAGE 1
HR. TEST END
CODE POINT
RESULT RESULT DOSE REF EMIC
NO ACT ACT (HID/LED) NUMBER NUMBER
SHORT CITATION
PLOT
DESCRIPTION TESTCOOES IN PHYLOGENETIC ORDER
Prokaryot Ic systems
ECS a E. coil or CE. coIl DNA) . strand breaks, crosslinks or repair
5*0 • Salmonella typhialirlus TA100, reverse na tatlon
5*9 • Salmonella typflhusjrltiu TA98, reverse nutation
EC2 • Escherfchie coil WP2, reverse nutation
Lower eukaryotic systems
5CC • Saccharomyces cerevisiae, gene conversion
SCR • Saccharcniyces cerevislas, reverse m tat ion
Insect systems
DNX a Drosophila melanogaster, sex-Linked recessive Lethal nutation
Animal cells In vitro
DIA a D MA strand breaks 1 crosst. or ret. daimge, animal cells In vitro
uRP . Unsche iled DNA synthesis, rat primary hepetocytes
NI.man cells In vitro
UHL a Unsche iLed DNA synthesis, hunan Lyrphocytes In vitro
UHY • Unsche ited DNA synthesis, transformed hunan cells In vitro
CHL • Chromosome I aberrations • hunan tyi flocytes in vitro
Animal In vivo
1 ECS
0
-
0
1000.0000
2188
30811
GRIFFIN AND HILL 161, 1978
2 5*0
0
-
-
182.0000
2308
50918
NISHIMURA, NISNMJRA, O$HII4A 305,
1982
3 5*9
0
-
-
182.0000
2308
50918
NISHDRJRA, NISHDRJRA, OSNIMA 305,
1982
4 EC2
0
-
0
1000.0000
2330
14190
ASHW000-SMITH, TREVINO, RING 418,
1972
5 SCO
R
-
0
0.0000
3511
FANRIG 161, 1974
6 SCR
0
+
0
5.0000
2390
24000
JERZ0MI , DEL CUPOLO, PONTI 161,
1976
7 DNX
0
-
0
10.0000
2130
6618
BElIES & SEAM 50, 1969
8 DIA
D
•
0
110.0000
532
50861
SIMA, BEAN, OYSART 357, 1983
9 URP
D
•
0
36.0000
740
37980
PROSST, MCMAHON , HILL 11, 1981
10 UIIL
0
.
0
100.0000
2280
37128
ROCCHI, PEROCCO, ALBERCHINI 101,
1980
11 UHT
0
•
•
0.4000
10019
24451
AHMEO, HART & LEVIS 161, 1977
12 CML
C
•
0
19.1250
2360
20048
GEORGIAN 103, 1975
13 MV II
H
-
0
13.0000
2273
35002
USHA EMIl, REDO!, REDDY 277, 1980
14 CBA
C
+
0
19.1250
2360
20048
GEORGIAN 103, 1975
15 DLX
C
•
0
40.0000
414
12984
EPSTEIN, ARNOLD, ANDREA 288, 1972
16 1CM
•
0
3.0000
3691
66349
ZIIONG-XIANG, KAVANAGH, TROSKO 10,
1986
(NO)
17 ICR
•
0
5.0000
3694
66306
KURATA, HIROSO & UPIEDA 217, 1982
(MO)
a Micronucleus test, mice In vivo
C5* a Chrcmoscmal aberrations, aninel bone marrow cells In vivo
-------
ALDRIN 9-JUL-87 PAGE 2
309-00-2
DU4 s Dcminont tethat test, mice
Atternetlve testcodes (not nctuded n profiLes)
ICN • Zrthibiticn of intercellular conmjnication, hu ian in vitro
ICR Inhibition of intercellular cc.am nIcat1on, rodent in vitro
ENDPOINT !NDICATIOiIS
0 a DNA damage R ReconCination G • Gene nn tation S $ SCE N — Micronucleus
C — Chromosome aberration A a Aneuptoidy T a Cell trensfortnetionF • Body fluids H • Hostmediated assay
-------
ND PRSENIC cX 1PcU1DS 1
f 4 ç The genetic toxicology of arsenic has been reviewed (Jacrtson-Kram
V & !‘b italbar , 1985).
In st’ xiy of ople exposed to trivalent arsenic in
drinking .water, r increase in the incidence of sister thra tid
exthanges or d raTosce 1 aberrations s observed (Vig et al. , 1984). A
nL.llber of other studies (IA , l98 ; Nordenson & Bec1 n, 1982)
published on pecple occipationally exposed to arsenic or stients
treated with arsenic have sho in increased levels of d r csa 1
aberrations or sister thraTatid exobanges. The interptetation of these
results r ine certain because of nethcxiological prob1et .
Trivalent arsenic did not induce dczninant lethal imitations in mice;
it produced a wall iz ease in dwceceaiml abe rations and micronuclei
in bone-iimrr i cells of mice treated in vivo . It induced d rai sa 1
aberrations and sister d rcestid exthanges in bran and i emtalian cells
in vitro , and u ,r * ological transfor ration of Syrian hanater etbryo
cells; it did not induce imitation in nanitalian cells in vitro . It
ipinced gene ivers ion in yeast bit did not cause imitation or induce
in bacteria.
Pentavalent arsenic induced c roscsaial aberrations in bran
and sazmalian cells in vitro ; equivocal results re obtained in assays
for the induction of sister chraiatid exthanges. It induced
nor *x,logical transfoL1I tion in Syrian haiiater tbryo cells • It did not
-------
iniuce nutation or - strand breaks in u ini lian cells in vitro or
t utaticn in bacteria.
qra *ts , 1, 41: 2, 48; 23, 39; Su ,l. 4 , 50
-------
ou i A 4 ’c dQAQ4c 1 OaUjt wo. _____
Subgrc*ip -
—— — — — - -fl-- e
t1on-n u 1ian sy.te
- - a-- - --
- -— — —-— -a - - —n—— -— — - - — “- —
Mamalian .ysta
- ------ Se - - nsa-a--—-- - -—
Proka- ukaxyotes
ryotee -
Is. er Plants Ins e cts
— yc ts — — ——
DGD ; A1DocADocA
in vitro Tnvivo
as— - ——— 5- — - —
Non-lunan Hizian Non-hiinan
— — — —. — — — — — — —. —
D SMCATI DOSNC T DGSMCkCLDGSMC
I
:
:
:
:
:
:
:
:
:
E
:
.
::
:
::
:
:
:
E
:
:
:
:
:
—_ d usge (3, gene nuthticn; C, thramemal aberr ticns; S. sister thraiatid exthanges; , aneuploidy, T, cell
transformation, IL, &ininant lethab H, micronuclei; R, mitotic rw*ththation or gene conversion; I, inhi.bition of intercellular
ctm2nicatlcE
-------
flPSEflIC +3
7440—38-2+3
9—JUL-B?
FM R C
if S
IIId N ff.(
S7 3 N
purgr
I (D( N
I L1 I
N IN N
I HI
8- —
I I I I
I I
Sc S S I
liii V II
(S L N I (S
6
4
TI
C?
S S
2-
0.
—2
—4. —
U i
I —
w
0
a
(3
0
-J
p
I I
I
N’
II
NM
-------
I I I I I II
P
S
A
A
S
I
CO
C
I
A
Ofl1
C
I
I
I
I
SI
H
I
A
X
fl
H
N
K VOT
LOSJ IJ( VOT PIM1TS P CTS
1 1T .$ Ni VIT
I* FM
Ni VIT
N B Ni VP O
.tI
Ni VPJO
RRSEflIC +3
7440—38-2+3
I
S
C
S
55 CC T 10 5
II II C 71 H
(S (S S 5 H I
9-JUL-87
I I
:c
II
H
IC
VI
IN
S
I.
H
8-
6- -
4.
2
o
-2-
—4- —
L i i
I—
C
3
w
In
0
0
1!:J
0
-J
-------
ARSENIC +3 9-JUL-87 PAGE 3
7440-38-2+3
HR. TEST END RESULT RESULT DOSE REF EI4IC SHORT CITATION PLOT
C00E POINT NO ACT ACT (HID/LED) NUNGER NUMBER
I PRB 0 - 0 750.0000 2007 37477 ROSSNAN, STONE, MOLINA 371, 1980
2 SAO 0 - - 2806.0000 1624 53403 TIEDENANK & ELNEROOT 170, 1982
3 SA2 0 - 0 3.8000 3516 58786 P ARZIN & PHI 49, 1985
6 SA5 0 - - 2806.0000 1624 53403 TIEDEI4ANN & EINBRDOT 170, 1982
5 SAT 0 - 2806.0000 1624 53403 TIEDEMANH & EINBRTT 170, 1982
6 SAl 0 - - 2806.0000 1624 53403 TIEDEMANN & EINBRDOT 170, 1982
7 5A9 0 - - 2806.0000 1624 53403 TIEDEMANN & EIMBRODT 170, 1982
8 ECR 0 - 0 2200.0000 100 4895 HE4ERLY & DEMEREC 69, 1955
9 ECR 0 - 0 0.0000 2007 37477 ROSSNAJI, STONE, MOLINA 371, 1980
10 ECZ 6 (+) 0 60.0000 73 20155 NISHIOKA 185, 1975
11 EC2 6 - 0 2200.0000 100 4895 NEWERLY & DENEREC 69, 1955
12 EC2 0 - 0 1800.0000 2007 37477 ROSSNAN, STONE, MOLINA 371, 1980
13 sco R • 0 150.0000 1074 49902 FUOJIAGA, KURACHI, MIZUQJCHI 3017, 1982
14 SCM C - 0 450.0000 1074 49902 FURUNAGA, KURACHI, MIZUGJCNI 3017, 1982
15 ONE 0 0 152.0000 299 32290 OUGATOVA, P00STAVKOVA & TREBATICKA 79, 1980
16 DIAl A 0 758.0000 299 32290 DUGATOVA, PODSTAVKOVA & TREBATICKA 79, 1980
17 0911 6 0 7.5000 2007 37677 ROSSMAN, STONE, MOL li lA 371, 1950
18 090 0 - 0 0.3750 2007 37477 ROSSMAN, STONE, MOLINA 371, 1910 (NO)
19 01* G 0 0.7500 3656 62006 LEE, 0SHI* A & BARRET 1421, 1985 (NO)
20 SIC S + 0 1.0000 939 45292 011110, NANAOKA, YAMADA 141, 1982
21 SIC S • 0 0.7500 1030 68043 WAN, CHRISTIAN & SOIJOJP 493, 1962
22 SIS S - 0 1.0000 1003 41825 LARRAMENDY, POPESCU, DIPAOLO 59?, 1981 (NO)
23 515 $ + 0 0.0600 3656 62004 LEE, OSHI*RA & GARRET 1421, 1985
24 MIA N - 0 47.0000 186 26541 DE B*ASAICER , VAN DE VEIRE, AERTS 357. 1976
25 CIC C + 0 0.7500 3514 63162 LEE, LEE, TZENG 119, 1916
26 CIC C • 0 0.0700 1030 48043 WAN, CHRISTIAN & SOJ(UP 493, 1982
27 CIS C • 0 1.0000 1003 61825 LARRAMENDY, POPESCU, DIPAOLO 597, 1981
28 CIS C + 0 0.5000 3656 62004 LEE, OSMI**A & BARIET 1421, 1985
29 TC$ T • 0 0.0100 3656 62006 LEE, OSNIPIA & BARRET 1421, 1985
30 T7S T • 0 0.2300 9 31323 CASTO, MEYERS & DIPAOLO 193, 1919
31 T1 5 T • 0 0.6000 485 44793 CANTO 241, 1981
32 DIN D - 0 4.0000 1076 45434 MCLEAN, WILLIAMS, KAPLAN 137, 1962
33 DIN 0 • 0 75.0000 1995 32855 FORIIACE & LITTLE 706, 1979
36 SNL S • 0 0.2000 949 41948 W, LIEU, CHANG 201, 1981
35 SIlL S (+) 0 0.0070 1572 45314 OGAWA, SNINICIII, NORITA 586, 1978
36 SIll. $ (•) 0 0.0600 1003 41825 URRAMENOY, POPESCU, DIPAOLO 597, 1981
31 SNI. S - 0 0.0600 1362 48960 CROSSEN 415, 1983 (NO)
38 SIlL S (+) 0 0.3000 1186 47953 NORDEIISON, Sl.EINS & BECKMAN 277, 1981
39 Sin_ 5 + 0 0.3100 297 39053 ZANEONI & JUNG 91, 1980
40 ClIP C + 0 0.0002 3086 13522 PATON & ALLISON 332, 1972
41 CML C • 0 0.0500 295 37658 NAKAIIMO & SAYATO 73, 1981
42 Cm. C • 0 0.0500 631 5446 OPPENNEIN & FISHBEIN 980, 1965
43 Clii. C • 0 0.1700 72 51729 SI !NS 249, 1963
44 cm. c + 0 0.0400 1030 48043 WAN, CHRISTIAN & souia 493, 1962
45 C X I. C • 0 1.0000 1003 41825 LARRAIENDY, POPESCU, DIPACLO 597, 1961
46 CI II. C • 0 0.0600 1156 67953 NOROENSON, SI INS & BECKMAN 277, 1981
47 CML C • 0 0.3100 297 39053 ZANZONI & JUNG 91, 1960
48 CIII C • 0 0.7500 3514 63162 LEE, LEE, TZENG 119, 1986
49 NVN N + 0 0.5000 3515 63246 DEKNLOT, LEONARD. ARAIIY 33, 1986
50 CU C • 0 1.7000 229 24105 SUM 25, 1976
-------
ARSENIC .3 9-JuL-87 PAGE 4
7440-38-2+3
HR. TEST END RESULT RESULT DOSE REF EMIC SHORT CITATION PLOT
00E POINT NO ACT ACT (HID/LED) N( 4BER NLJ4BER
51 CM C - 0 12.0000 795 39769 PO4A, DEGRAEVE, KIRSCH-VOLDERS 129, 1981
52 C C C C - 0 12.0000 795 39769 POIA, DEGRAEVE, KIRSCH-VOI.DERS 129, 1981
53 DIM C - 0 250.0000 109 17760 SRAM & BENCKO 308, 1974
54 DIM C - 0 5.0000 3515 63246 DEKNWT, LEONARD, ARANY 33, 1986
55 SLI4 S + 0 0.0000 63 26424 BURGDORF, KURVINK & CERVINKA 69, 1977
56 SLH S 0 0.0030 3655 57012 VIG, FIGUEROA, GORNFORTH 325, 1984 (NO)
57 CI H C - 0 0.0000 63 26424 BURCCORF, KURVINK & CERVINKA 69, 1977
58 C1.H C 0 0.0030 3655 57012 VIG, FIGUERGA, GORNFORTH 325, 1984 (N0
DESCRIPTION TESTCODES IN PHYLOGENETIC ORDER
Prok.ryot ic systems
PRB Prophage, induction, SOS repair, DNA strand breaks or crosstinks
SAO • SaLmoneLLa ty ilSiriLim TA100, reverse .itation
SA2 • SaLmoneLLa ty hiim. rii.. 1A102, reverse ..ltation
5*5 SaLmoneLLa typhiesariia 1A1535, reverse imitation
5*7 • SaLmoneLLa ty h,imarita TA1537 , reverse imitation
5*8 SaLmonelLa typhi.iriua 1A1538, revers. imitation
5*9 • SalmoneLLa ty mor$ 1A98 , reverse imitation
EC2 • Escherichi. coLl WPZ. reverse su.itatlon
ECR • Escherlchla coil (other misc, strains), reverse imitation
Lower .ukaryottc systems
5CC $ Saccharo.yc.s cerevisi.e, gene conversion
5CR • Saccharcmyces cerevisia., reverse Imjtation
Insect systems
Dl i x • DrosophiLa .stanoguter, sex-Linked recessive LethaL imitation
OliN • Drosophi La metanoga*ter, anei . Loidy
Anit ceLLs in vitro
G9 1 1 • Gene imitation, Chines. hter Lung V-79 celLs In vitro, NPRT
G90 • Gene imitation, Chines. hter Lung V-79 cells In vitro, ouabain
CIA a Gene .Jtation, other animi cells In vitro
SIC a Sister chromstld exchange, Chinese ht.r ceLLs in vitro
SIS a Sister chrctid exchange, Syrian hamster celLs in vitro
MIA a Micro, icLeus test, animal celLs in vitro
CIC a Chromoscm.l aberrations, Chinese hter celLs in vitro
a Chromosomst aberrations, Syrian hamster ceLLs In vitro
a CelL transformation, Syrian hter eabryo cells, cLonai assay
175 = CelL tr.nsform.tion, SA7/Syrien hamster eabryo c ci Is
H man ccl La in vitro
DIN a DNA strand breaks, crossL. or reL. d ge, huimn cells in vitro
SHL a Sister chrom.tid exchange, hulian Lyw hocytes in vitro
CNF a ChromosamaL aberrations, hi.msn fibroblasts in vitro
-------
ARSENIC +3 9-JUL-87 PAGE 5
7440-38-2+3
041. Chr s ..t aberrations, hurmn i ç hocytes in vitro
CI I I Chro.osot aberrations, other hu.n cetis in vitro
Anit in viva
WiA I I4icrori. cteus test, mice in viva
CU Chromosc..1 aberrations, anieat bans rro ceLls in viva
CGG Chro scm.t aberrations, spera.togonia treated in viva arid gania abs.
DLII a Dominant LethaL test, mice
l4t in viva
SLN Sister throestid exchange, hiamn l hocytes in viva -
CLII a Chro.osoe.t aberrations, hi.i L hocytes In viva
ENDPOINT INDICATIONS
0 a DNA daw.g. R a Reccabin.tion G a Gene .Jtation S a SCE N MicronucLeus
C Chro scme aberration A • Ane. toidy T a CelL tranafermutionF a Body fLuids N a Nost.edi.ted assay
-------
d c i ’e CdkL az ,td (pwJ L&J -
Subgrcx p _______
syatei
-s-- - -e
Eukaryotes
.
t4anm 1ian ayetai
-_ -e*.eea fla -a -
In vitro Invi q
— -
er
eukar v
— —
tee
S. S
Plants
.
— — — —
Insects
— — —
Non-htjnan
.
5— — —. —, — — —
Hisnan
.
— — — — — 5 — S
Non-h i n an
— — —— —. — — —
Wuan
— — — — — —-
;
AID
0
C
A
D
0
C
A
D
S
H
C
A
T
I
D
3
S
P1
C
AT
D
3
S
H
C
A
IL
D
3
S
H
CA
—
—
—
—
——
——
—
——
— —
?
—
—
—
—-
—
+
5—
—
-
—,
S .—
?
-t-
—
—
—
—
—
S.— —
D, L I lA damage; 0 . gene nutation; C, d raiosanal aberrations; S sister chranatid exchanges; A, aneuploidy. P. cell
transformation. IL, dcaninant lethab M, znicronuclei; R, mitotic recxxnblnaticn or gene caiversion; I, inhibition of intercellular
cc mnunl cation
-------
RPSEflIC + g-JUL--8?
7440-38-2+5
8— I I I I I I I
6 —
4-
U)
I.—
2-
3
U)
In
A a U
I FM REC G fl IUTRTIOfl I I I I “ I I
-------
flPSEflIC +5
7440—3B-2+5
9-JUL--B?
I I I I I I II I I
S
C
II
55 Ct T
II IS C
(S (S S
SC
If N
I. L
DII G I U
II SI I H
52 I D I I YR II F
PROK 1YOT LC* U( VOTE* P.R1T t CT Ii VITRO IUW FM fl VI
Ii VITRO 1) VIVI
8 —
6- —
4
2-
0 .
—2-
-4- -
U i
I—
C
U i
In
0
0
Ui
0
-J
A
-------
ARSENIC +5
7440-38-2+5
9-JUL-87 PAGE 6
NA. TEST E
C00E POINT
RESULT RESULT
NO ACT ACT
DOSE REF ERIC
(MIDILED) NIMBER NUMBER
SNORT CITATION
PLOT
DESCRIPTION TESTC00ES IN PHYLOGENETIC ORDER
Pro&sryotlc syst
5*0 a Sat netLa typhiiriLa TA100 , reverse .ttatlcn
sA2 a SaL.onst La ty I*ah. TAb?, rivers . .itation
5*5 a Sst.oneLta t iarh TAIS3S, reverse sitation
5*7 a Sataons(La t isiri a TA1537, revere. sitati on
5*6 a SaLsinetta t iisir1 .a TA1538 , r rse sitatlon
5*9 Sa&.onetta tWhisiriUM TA98, revere. a.atation
Esch.ricS i. coIl 2 uvrA, revers sitatlon
Lower .t*.ryotlc yet
SCM a S. cerevisle., hc.ozy osls by recc Instlon or gene conversion
Insct syst
I SAO
G
-
-
270.0000
589
31646
SIIIqON, MITCHELL & JORGENSON 1, 1977
2 S*0
G
-
•
3700.0000
1624
53403
TIEDEMANN & EINBR00T 170. 1982
3 5*2
0
-
0
38000
3516
58786
NARZIN & PHI 49, 1985
4 sA5
0
-
-
270.0000
589
31446
SI qON, MITCHELL & JORGENSON 1, 1977
S 5*5
0
-
-
3700.0000
1624
53403
TIEDEMA IN & EINBRODT 170. 1982
6 SAT
0
-
-
270 0000
589
31446
SII! 0N, MITCHELL & JORGENSON 1, 1977
7 SAl
0
-
-
3700.0000
1624
53403
TIEDEI4ANN & EINBR00T 170, 1982
8 5*8
0
-
-
270.0000
589
31446
SIJIOI, MITCHELL & JORGENSON 1, 1977
9 5*8
0
-
-
3700.0000
1624
53403
TIEDEMMN & EINBROOT 170, 1982
10 SA9
0
-
-
3700.0000
1624
53403
TIEDEMAIIN & EINBRODT 170, 1982
11 ECW
0
-
-
270.0000
589
31446-
SIiI 0N, MITCHELL & JORGENSON 1, 1977
12 SCM
A
(.)
•
27000.0000
589
31446
SM ON , MITCHELL 6 JORGENSON 1, 1977
13 oss
&
-
0
8.0000
2001
34221
RAIEL & MAGNUSSON 59, 1979
14 01*
0
-
0
45.0000
532
50841
SINA, BEAN, DVSART 357, 1983
15 051
0
-
0
19.6000
809
37075
AUCHER a PAILLET 279, 1980
16 01*
0
-
0
7.5000
3656
62004
LEE, OSNI*JRA 6 NARRET 1421, 1985
17 SIC
S
•
0
3.2000
939
45292
ClING, NAMAO(A, YAMACA 141, 1982
18 SIS
S
•
0
2.4000
1003
41825
LA&RAIEICY, POPESCU, DIPAOLO 597, 1961
19 SIS
S
•
0
0.7500
3656
62004
LEE, OSNI*JRA & BARRET 1421, 1985
20 11*
II
-
0
4.2000
166
24541
05 BEABAIIDER, VAN DE VEIRE, AERTS 357,
1976
21 CIC
C
+
0
3.7000
1030
68043
MM, CIIRISTIAM & S JKIW 493, 1982
22 CIS
C
•
0
2.4000
1003
41825
LARRAIIEWOY, PORESOJ, DIP*OLO 597, 1981
23 CIS
C
•
0
4.8000
3656
62004
LEE, OSM1IIJRA & BARRET 1421, 1985
24 TCS
I
+
0
2.5000
15
502
DIPAOLO & CASTO 1006, 1979
25 TCS
T
•
0
0.6000
3656
62006
LEE, OSIII**A & BARREl 1421, 1965
26 UHF
0
-
-
75.0000
589
31646
SIINION. MITCHELL & JORGENSON 1, 1977
27 SIlL
S
0
1.4000
1362
48960
CROSSEN 415, 1983
28 SIlL
S
(+)
0
2.4000
1003
41825
LARRAMENDY, POPESCU, DIPROLO 597, 1981
29 SIll.
S
-
0
0.0007
1572
45314
OGMIA, SNIWICHI, NOAITA 584, 1978
(NO)
30 CML
C
-
0
0.0004
3086
13522
PATON & ALLISON 332, 1972
(NO)
31 CML
C
•
0
0.2000
295
37658
MAICAINJRO & SAYATO 73, 1981
32 CML
C
•
0
2.4000
1003
41825
LARRAMENDY. POPESCIJ, DIPAOLO 597, 1981
33 CML
C
-
0
0.2000
1186
47953
MOROEWSON, SUEINS £ BECXNAM 277, 1981
(MO)
DI II • Drosophi (a ..(anog.st.r, .n.i. Loidy
-------
AnimaL cefls in vitro
01* DNA strand breaks, crosst. or ret, damage, animaL celLs in vitro
G5T Gene imitation, mouse L5178Y cells in vitro, 1K locus
GIA Gene imitation, other animal ceLLs in vitro
SIC Sister chromatid exchange, Chinese h ter cells in vitro
SIS Sister chromatid exchange, Syrian hamster celLs in vitro
MIA s Micronucleus test, animal celLs in vitro
dc Chromosom.L aberrations, Chinese h ter cells in vitro
CIS z Chromosomat aberrations, Syrian hamster celLs in vitro
TCS s Cell transformation, Syrian hamster eatryo cells, cLonal assay
Ht.n celLs in vitro
UHF • Unsche Led DNA synthesis, huiian fibroblasts in vitro
SHL • Sister chromatid exchange, hi an Lynçhocytes in vitro
C ML • Chromosomal aberrations, hi.imsn l içhocytes in vitro
ENDPOINT INDICATIONS
0 * DNA d ge R Recos ination G • Gene imjtation S SCE M • MicronucLeus
C • Chromosome aberration A • Anetloidy T • CelL transformationF • Body fluids N z Nostaiediated assay
-------
B E1
DO NOT CITE OR QUDTE
roi cso 1 aberrations in himian peri teral ].ynç*tocytes were
associated with occupational exp sure to benzene, although meny of these
st ziies are very difficult to interpret.
Benze e irx uced d rax som]. aberrations, Micronu l and sister
chrai tid exchanges in bone tiarrow of mice, chrxcsa ai. errat ions in
bone merrow of rats and Qunese hamsters d sperm-heed anometies in
mice. It induced chron,soiTal 4 errat ion 4 y tatton in humen cells in
vitro . Benzene did not tr uce sister chronati* exxthaxiges in cultured
humen ly iç cytes except in one study Eiidi hi ccc centrat ions of an
exoge us metabolic y t u were q 4, In est systeme, benzene
induced Berzene did not induce
sister d ra tid pges r& ’rm 1ia 4s in vitro , but did induce
aneupLotdy , in s e ztndies, thrcnx soiial aberrations in cultured
ceLtz;:::The x cund induced mutation and Ct.
damage st te in *ian cells in vitro .
In 2 J b 1Z he was reported to be weakly positive in assays
for s atic tati âth for crossing-over in spermato xiia; in single
Stiñieg, the x nLx)und did not induce sex—linked recessive mutations or
trans].ocations. It induced aneuploidy, mutation and gene ocnversion in
fungi. Benzene was not mutagenic to bacteria.
1 IA ! . qra* s , 7, 203; 29, 93, 391; Suppl. 4 . 56
-------
ayatai $auuvdtaa% ayst I
-- - - - - ---
fuikaryot.es
vtro
Invivo
1aIr
°r
-
z _
Rz n
AI 0
0
C
A
D
0
C
A
D
S
H
C
A
t
I
D
(
)*
C
AT
0
0
S
14
C
A
IL
0
0
S
H
C A
: :
:
:
:
:
:
E
:
!
:
::
:
:
E
:
:
:
:
0. lilA d m ge: 0, ger nutation; C d roIE a’al aberration8; S. si8tUr ch t141eX4i4Wje8 A Loidy T, cell
t.ronafonnation , IL, dc ninant lethab H, micronuclei; R, initotic rca 1t t genetx*iversiona I j thhth ition of intercellular
0 _____ __
110.
Subgroup ______
c icaUon
-------
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SENZEt4E
71-43-2
9-JUL-87 PAGE 7
1 1 g. TEST END
E POINT
RESULT RESULT
NO ACT ACT
DOSE REF ENIC
(HID/LED) MLJ BER NLI4BER
SHORT CITATION
PLOT
1 PRB
D
0
-
22000.0000
2521
43495
HO & HO 532, 1981
2 850
D
c.
0
40200.0000
892
41826
NCCARRO&L, KEECH & PIPER 607, 1981
3 SAF
G
-
•
500.0000
1701
59615
USER 213, 1985
4 SAG
0
-
-
510.0000
80
26484
COTRUVO, SI* OW & SPANGGORD 124, 1977
S 5*0
c
-
-
2340.0000
357
37207
FLORIN, RUTBERG, CURVALL 219, 1980
6 5*0
0
-
•
500.0000
1699
59613
ZEIGER & HAWORIN 187, 1985
7 SAD
0
-
-
2500.0000
1700
59614
REXROAT & PROSST 201, 1985
8 saQ
C
-
•
1000.0000
1698
59612
MTSUSHINA, *JR*I4ATSU & HARESAKU 181, 1985
9 5*0
0
-
-
2.3000
1321
48947
SNIMIZU, YASUL, MATSLB 0T0 217, 1983
10 5*0
C
-
-
5000.0000
1697
59611
BAKER & SONIN 177, 1985
11 5*5
0
•
-
510.0000
80
26684 -
COTRUVO, SIIB ON & SPANGOORD 124, 1977
12 5*5
6
-
-
234.0000
357
37207
FLORIN, RUTBERG, CURVALL 219, 1980
13 5*5
6
-
-
2500.0000
1700
59614
IEXROAT & PROSST 201, 1985
14 SA5
C
-
-
500.0000
1899
59613
ZEIGER & MANORTH 187, 1985
15 5*5
0
-
-
2.3000
1321
48947
SHINIZU, YASUI. MATSUMOTO 217, 1983
16 SAl
C
-
-
510.0000
80
26684
COTRUVO, SDB OlI & SPANGGORD 124, 1977
17 SAT
C
-
-
234.0000
357
37207
FLORIM, RUTBERG, CURVALL 219, 1980
18 5*7
0
-
-
2500.0000
1700
59614
REXPOAT & P00851 201, 1985
19 SAT
C
-
-
2.3000
1321
48947
SNU4IZU, TASW, MATSUMOTO 217, 1983
20 SAT
0
0
-
2028.0000
1519
48129
SEIXAS, * 1 100 W, HOLLINOSHEAD 201, 1982
21 SM
C
-
•
510.0000
80
26484
COTRUVO, SDWON & SPANGG000 124, 1977
22 5*8
6
-
-
2500.0000
1700
59614
REXRO*T $ PROSSY 201, 1985
23 5*8
C
-
-
2.3000
1321
48947
SHIMIZU. YASUI, NATSUMOTO 217, 1953
24 5*9
6
0
-
50.0000
887
41662
110, CLARK, QJERIW 335, 1981
25 5*9
-
.
510.0000
80
26484
COTRUVO, SDW OW & SPAMGGORD 124, 1977
26 5*9
6
-
•
0.2340
357
37207
FLORIN, RUTBERG, CURVALL 219, 1950
27 sA9
C
-
-
2500.0000
1700
59614
REXROAT & PRO8ST 201, 1985
2$ 5*9
6
-
-
500.0000
1699
59613
ZEIGER & NAWORTN 187, 1985
29 5*9
0
-
•
1000.0000
1698
59612
MATSUSHIMA, MURAMATSU & NARESAKU 181, 1985
30 5*9
0
-
-
2.3000
1321
43947
SNINIZU, YASUI, MAT JI0T0 217, 1983
31 5*9
C
-
-
5000.0000
1697
59611
BAKER & BONIN 177, 1985
32 SAS
C
-
-
500.0000
1699
59613
ZEIGER & HA%JORTH 187, 1985
33 5*5
C
-
-
1000.0000
1698
59612
MATSUSNII4A, **AMATSU S HARESA IQJ 181, 1965
34 5*5
C
-
•
5000.0000
1697
59611
BAKER S 80111W iTT, 1965
35 5CC
R
•
.
1100.0000
1708
59623
MENTA S VOW BOASTEI. 271, 1965
36 5CC
1
•
(+)
200.0000
1707
59622
PARRY S ECKARDI 261, 1985
37 5CC
1
-
-
880.0000
1706
59620
INGE-VECHTONOV, PAVLOV, WOSIC0V 243, 1985
3$ 5CC
1
-
-
2000.0000
1703
59617
BROOKS, GONZALEZ, CALVERT 225, 1985
39 5CC
1
-
-
500.0000
1702
59616
ARifi 217, 1985
40 scn
R
-
-
510.0000
60
26484
COTRUVO, SDe ow & SPARGG000 124, 1917
41 SCN
1
-
-
500.0000
1702
59616
ARNI 217, 1985
62 SCII
R
-
-
860.0000
1706
59620
INGE-VECNTOMOV, PAVLOV, WOSI (OV 243, 1985
43 SCF
C
-
-
880.0000
1706
59620
INGE-VECNTONOV, PAVLOV, NOSKOV 243, 1985
44 SCF
C
•
0
300.0000
1704
59618
FERSUSON 229. 1985
45 5CR
C
-
•
100.0000
1107
59622
PARRY S ECKAROT 261, 1955
46 5CR
S
-
-
500.0000
1702
59616
ARWI 217, 1985
47 5CR
C
-
-
880.0000
1706
59620
IWGE-VECHTONOV, PAVLOV, NOSW4 243, 1985
48 5CR
S
•
•
275.0000
1708
59623
MENTA S VON BORSTEL 271, 1985
49 SZF
C
-
-
1000.0000
1710
59625
LOPRIEIIO, BONCRISTIANI, FORSTER 297, 1955
50 AMP
6
-
0
2197.5000
1711
59626
CARERE, COIflI, CONTI 307, 1985
(NO)
-------
BENZENE
71-43-2
9-JUL-87 PAGE 8
HR. TEST END
COGE POINT
RESULT RESULT DOSE REF EMIC
NO ACT ACT (HID/LED) NUMBER NUMBER
SHORT CITATION
PLOT
51 SCM
A
•
•
0.0000
1709
59624
PARRY & ECKARDI 285, 1985
52 TSM
G
+
0
12.8000
56
31304
SCHAIRER, VAN’T HOF, HAYES 421, 1978
53 TSM
0
(+)
0
12.0000
1504
59997
SCHAIRER, SAUTKULIS, TEMPEL 211, 1983
54 D#4I
G
-
0
64.0000
51
27482
NYLANDER, OLOFSSON, RASMUSOSI 163, 1978
55 0*
C
C+)
0
156.0000
1712
59627
VOGEL 313, 1985
56 0*
0
C .)
0
39.0000
1714
59629
RJRGLER, GRAF & FRET 325, 1985
57 0*
0
-
0
17600.0000
1713
59628
FUJIKAW*, RYO & KONDO 319, 1985
58 0MG
R
(+)
0
630000
1423
50725
KALE 223, 1983
59 DM0
R
-
0
156.0000
1712
59627
VOGEL 313, 1985
60 DM0
R
-
0
39.0000
1714
59629
AJRGLER, GRAF & FREt 325, 1985
61 DMX
0
-
0
86.0000
1423
50725
KALE 223, 1983
62 0MM
C
-
0
84.0000
1423
50725
KALE 223, 1983
63 DIA
0
-
-
780.0000
2386
23583
S1 ENBERG, PETZOLD & HARBACH 732, 1976
64 01*
0
-
0
234.0000
532
50841
SINA, BEAM, DYSART 357, 1983
65 DIA
0
+
-
1328.0000
1719
59634
LAXHANISKY & HENDRICKX 367, 1985
66 01*
0
-
-
234.0000
1718
59633
DOUGLAS, BLAKEY, LIU-LEE 359, 1985
67 01*
0
-
0
261.0000
1717
59632
BRADLEY 353, 1965
68 liMP
0
-
0
39.0000
740
37980
PROBST, MCMAHON. HILL 11, 1981
69 LiMP
0
-
0
10000.0000
1715
59630
WILLIAMS, TONG & VED BRAT 341, 1985
70 URP
0
-
0
390.0000
1722
59637
PROBST & HILL 381, 1965
71 URP
D
•
0
78.0000
1720
59635
GLAUERT, KENNAN, SATTLER 371, 1985
72 OCO
C
-
-
880.0000
1743
59659
ZOZIENICKA & SIMONS 583, 1985
73 0911
G
-
-
2000.0000
1736
59651
FOX & DELON 517, 1965
74 0911
0
-
0
500.0000
1745
59661
ELNORE, KORYTYNSKI & SMITH 597, 1985
75 0911
0
(+)
-
50.0000
1739
59654
KUR00A, YOKOIYAMA & KADA 537, 1985
76 05T
C
-
-
860.0000
1741
59657
MYHR, B iRS & CASPARY 555, 1965
77 GST
0
7
-
250.0000
1744
59660
STYLES, CLAY & CROSS 567, 1965
78 OST
C
-
C.)
100.0000
1742
59658
OBERLY, BEVSEY B PROBST 569,, 1965
79 OST
C
-
-
352.0000
1738
59653
KNUP B LANGEBROEK 531, 1965
80 GST
C
-
-
1062.0000
1734
59649
AMACHER & TURNER 467, 1985
81 GST
G
-
-
1000.0000
1770
52232
OBERLY, BEWSEY, PROBST 291, 1986
82 051
C
-
-
352.0000
1738
59653
KNAAP & LANGEBROEK 531, 1985
83 051
G
7
•
62.5000
1764
59660
STYLES, CLAY & CROSS 587, 1985
86 051
C
•
-
200.0000
1737
59652
GARNER & CAMPBELL 525, 1965
85 SIC
S
-
-
937.0000
1727
59642
NATARAJAN, BUSSMANN, VAN LEEUWEN 433,
1965
86 SIC
S
-
-
1000.0000
1730
59645
LANE, PHILLIPS B ANDERSON 451, 1985
87 SIC
S
-
-
3905.0000
1732
59647
VAN WENT 469, 1985
88 SIC
S
-
-
781.0000
1718
59633
DOUGLAS, BLAKEY, LIU-LEE 359, 1985
39 SIC
S
-
-
5000.0000
1725
59640
SULATI, SABMARWAL & SHELBY 413, 1985
90 SIR
S
-
0
1000.0000
1723
59638
PRISTOII & DEAN 387, 1985
91 PITA
N
-
-
7810.0000
1718
59633
DOUGLAS, BLAKEY, LIU-LEE 359, 1985
92 CIC
C
-
0
250.0000
1724
59639
DANFORO 397, 1985
93 CIC
C
•
•
600.0000
1729
59664
PALITTI, FIORE, DE SALVIA 443, 1985
94 CIC
C
-
•
550.0000
1726
59641
ISHIDATE & SOFUNI 427, 1985
95 CIC
C
-
-
937.0000
1727
59642
MATARAJAN, BUSSMANN, VAN LEEUWEN 433,
1985
96 dc
C
-
-
5000.0000
1725
59640
GULATI, SABHARWAL & SHELBY 413, 1985
97 CIR
C
-
0
1000.0000
1723
59638
PRISTON & DEAN 387, 1965
96 AlA
A
-
0
1000.0000
1723
59638
PRISTON & DEAN 387, 1985
99 AlA
A
-
-
4400.0000
1726
59641
ISHIDATE & SOFUNI 427, 1985
100 AlA
A
•
0
62.5000
1733
59648
PARRY 479, 1985
-------
BENZENE
71-43-2
9-JUL-87 PAGE 9
MR. TEST END
CODE POINT
RESULT RESULT DOSE REF ENIC
MO ACT ACT (HIOILED) NUMBER NUMBER
SNORT CITATION
DESCMIPT ION TEST ODES IN PHYLOGENETIC ORDER
Proksryotic syst
FRI a ProØ,.g. , cdjctIon , SOS repair, 08* strand breaks or crosst Inks
$50 a BacilLus st tiLis rec strains, differantiat toxicity
SAF z Sat nMLa typhl.jrita, forward jtation
101 AlA
A
•
0
2500000
1724
59639
DANFORO 397, 1985
102 TIN
T
-
.
2933.0000
1751
59666
MATTHEWS, DELBALZO & RUNDELL 639, 1985
103 TIM
T
-
0
4000.0000
1538
60000
RUNOELL, 0.JNTAKATTA & MATTHEWS 309, 1983
104 TCN
I
-
-
320.0000
1752
59667
LAWRENCE & MCGREGOR 651, 1985
105 TCN
T
-
0
1000.0000
1753
59668
MESNOJ, QJRIIS I GARLAND 659, 1985
106 TCI.
T
-
880.0000
1749
59671
ZDZIENICKA, DE KOK & SIMONS 685, 1985
107 TCS
T
•
0
20.0000
1754
59669
SAMNER & RIVEDAL 665, 1985
108 TCS
I
•
0
10.0000
1748
59664
BARRETT & LAMB 623, 1985
109 TCS
T
(+)
0
35.0000
1283
49916
MACHER & ZELLJADT 291, 1983
110 TTS
T
-
0
0.5000
1750
59665
HATCH-A ANDERSON 629, 1985
111 LINT
0
-
-
660.0000
1716
59631
BARRETT 347, 1985
112 GIN
0
•
-
1000.0000
1735
59650
CRISP!, RYAN, SEIXAS 497, 1985
113 SIlL
S
-
0
1520.0000
52
31107
GERNER-9IIDT & FRIEDRICH 313, 1978
114 SIlL
S
-
0
391.0000
305
37345
HORINOTO & WOLFF 1189, 1980
115 SHI..
S
-
-
600.0000
1728
59643
O lE, HILLE, JONAS 439, 1985
116 SIlL
S
-
•
15.6000
1263
49576
MORIMOT0 1330, 1983
117 CMI.
C
-
0
1520.0000
52
31107
GERNER-SMIOT a FRIEDRICH 313, 1978
118 C ML
C
•
+
9.0000
1731
59646
Ha4*R0, SHELDON & RICHARDSON 457, 1985
119 SVA
S
•
0
17.0000
945
48262
lICE, WOGT a COSTA 257, 1982
120 sva
S
•
0
0.0000
306
39661
lICE, COSTA & DREW 2148, 1980
121 NVM
N
•
0
88.0000
999
45310
TUNER, HOGSTEDT, OI.OFSSON 129, 1982
122 MVN
N
•
0
88.0000
503
52374
G*0-EL-KARIM, HARPER a LEGATOR 225, 1984
123 MVM
N
•
0
56.0000
943
41698
SIW, CONAN, HAITEN 273, 1981
124 MVN
N
•
0
180.0000
304
36503
DIAZ, REISER, BRAIER 297, 1980
125 N l
N
•
0
4400.0000
308
37627
siai & SQJRDEIX 531, 1980
126 W Al
N
•
0
220.0000
310
36486
SlOW & CONAN 433, 1977
127 ...
N
•
0
112.0000
255
34357
luTE, PECHARO, SMITH 149, 1980
128 NYN
N
•
0
440.0000
303
34811
PETNE & LEGATOR 43, 1980
129 NVN
N
•
0
140.0000
1256
50123
lOFT, OLOFSSOB, TUNEE 295, 1982
130 NVC
N
-
0
8800.0000
943
41698
lION, CONAN, HAITEN 273, 1981
131 CIA
C
•
0
22.0000
502
52371
STYLES 4 RICHARDSON 203, 1986
132 CIA
C
•
0
88.0000
503
52374
GAD-EL-KARIM, HARPER & I.EGATOR 225, 1984
133 CIA
C
•
0
56.0000
963
41698
SlOW, CONAN, HAITEM 273, 1981
134 CIA
C
•
0
878.0000
909
34998
ANDERSON & RICHARDSON 261, 1981
135 CIA
C
-
0
2300.0000
306
39661
TICE, COSTA a DREW 2148, 1980
136 CIA
C
+
0
440.0000
303
34811
MEY1IE a LEGATOR 43, 1980
137 SIN
S
()
0
4.6000
2054
52522
SANTO, CONIMATO, PINTON 827, 1984
138 CIN
C
•
0
860000
738
7729
FORMI, PACIFICO & LIMONTA 373, 1971
139 CLII
C
-
0
0.0000
268
36225
FREDGA, RELTALU 4 BERLIN 187, 1979
140 CIN
C
•
0
1.3000
269
33437
PICCIANO 33, 1979
141 CIN
C
•
0
0.0000
625
6535
TONGII a CaINT-BROIRI 684, 1965
142 CLN
C
•
0
6.6000
2054
52522
SARTO, CONINATO, PINTON 827, 1984
11 .3 SPIl
•
0
500.0000
597
37395
TOPIIAM 379, 1980
(HO)
-------
BENZENE 9-JUL-87 PAGE 10
71-43-2
5*0 • SaLmonelLa tyhiiejri 1*100, reverse imitation
5*5 • SaLmonelLa typhiimiriuu TA1535, reverse Imjtation
5*7 SaLmoneLLa tyhiim rius 1*1537, reverse imitation
5*8 • SaLmoneLLa typhimjri*.im TA1538 , reverse imitation
5*9 • SaLmoneLLa typhimjrius 1*98, reverse imitation
5*5 a SaLmoneLLa tyhhum rius (other misc, strains), reverse Imitation
Lower eukaryotic systems
SCG • Saccharoiwyces cerevisiae, gene conversion
SCH S. cerevisiae, homozygosis by recoabination or gene conversion
SCF • Saccharoivyces cerevisiae, forward Imitation
5CR • Saccharomyces cerevisia., reverse imitation
SZF • Schizosaccharomyces poate, forward Imitation
AJIF Aspergittus niditans, forward imitation
S Q l a Saccharomyces cerevisiae, anet toidy
PLant systems
15$ • Iradescantia species, m.itatlan
Insect systems
D$G • DrosophiLa meLanogaster, genetic crossing-over or recoatinatlon
a DrosophiLa .stanogaster, somatic imitation (and r.coatin.tfon)
D$X • DrosophiLa metanogaster, sex-Linked recessive LethaL .itat lon
Ol IN • Drosophi Ls metanogaster, heritabLe transLocatlon test
AnimaL ceLLs In vitro
01* • DNA strand breaks, crosst. or ret. dg., animaL ceLLs In vitro
URP • Unsche iLed DNA synthesis, rat primary hepatocytes
6CC • Gene imitation, Chinese hamster ovary ceLLs in vitro
691 1 Gene Imitation, Chinese hamster Lijig V-79 cit La in vitro, NPRT
GST • Gene imitation, mouse L5178Y ceLLs in vitro, 1K Locus
651 a Gene imitation, mouse L5178Y ceLLs in vitro, aLL other toci
SIC • Sister chroamtid exchange, Chinese ht.r ceLLs in vitro
SIR a Sister chrom.tid exchange, rat ceLLs in vitro
NIA a MicronucLeus test, animaL ceLLs in vitro
CIC a chromosomat aberrations, Chinese hamster oct La in vitro
CIR • Chromosomat aberrations, rat ceLLs in vitro
*1* • Anet Loidy, animaL ceLLs In vitro
IBM • CeLL transformat ion, ULB/C3T3 mouse cit La
101 a CeLL transformation, C3HIOT1/2 mouse ceLLs
TCS a CeLL transformation, Syrian ht.r eutryo ceLLs, ctonaL assay
a CeLL transformstion, other estabLished ceLL tines
175 a CeLL transformation, SATISyrian hter eatryo ceLLs
Ntamn ceLLs in vitro
UNT • Unsche .ited DNA synthesis, transformed h.sn ceLLs in vitro
-------
BENZENE 9JUL-87 PAGE 11
71-43-2
GIN • Gene Itation , h*.n ceLLs in vitro
SIlL • Sister chro tid exchange, In n L hocytes in vitro
C I II Chra.osam.L aberratfons h,.an L ocytes in vitro
Ani L in viva
SVA • Sister chr tid exchange, animaL ceLLs in viva
• MicronucLeus test, mice in viva
NVC • MicronucLeus test, hters in vivo
CM Chrc.osc.eL aberrations, animaL bone m.rrow ceLLs in viva
Ik n In viva
SLN * Sister chrotid exchange, htn L ocytes in viva
CLII • Chr ’ somat aberrations, ht n L hocyt.s in viva
ALternative teetcodes (not incLuded in profiLes)
a Sperm morphoLogy, mouse
ENDPOINT INDICATIONS
D • DNA d ge N • Reco ination G * Gene .Jtation S • SCE N • MicronucLeus
C • Chr snae aberration A • An. Loidy T • C.L & transfor.stionF = Body fLuids N • Nosteediated assay
-------
BENZO(A)PYRENE
Benzo(a)pyrene, in single studies, did not induce unscheduled DNA
synthesis in rats or specific—locus mutations in the offspring of male
mice. The offspring of treated female mice displayed somatic mutations
in one study. Sister chromatid exchanges and micronuclei were induced in
ma aljan cells treated in vivo . Dominant lethal mutations were induced
in a single study with mice. B(a)P caused unscheduled DNA synthesis and
gene mutations in human cells in vitro . DNA d Tnage was induced in
n imn*lian cell cultures as measured by DNA strand breaks, repair of
strand breaks and unscheduled DNA synthesis. Gene mutations, sister
chromatid exchanges and chromosomal aberrations were induced in mAm lian
cells in vitro . Cell transformation occurred in m. ”m lian cell lines
exposed to B(a)P. In single studies in Drosophila melanogaster , B(a)P
induced somatic mutations and weakly increased aneuploidy. It did not
induce sex—linked recessive lethals except in one tudy where it was
weakly positive. In the presence of an exogenous metabolic system, B(a)P
was mutagenic in bacteria and induced prophage and differential toxicity
in ! coli . Gene conversion and aneuploidy were induced in yeast, but
recombination and mutation were not. B(a)P caused mutations and micronuclei
in single studies in Tradescantia . It was active in in , nalian body fluid
assays but not in host—mediated assays in mice.
-------
Compound Benzo(a)pyrene
Non—niaimnalian Systems
Memsalian Systems
Proka-
ryotes
lukaryotes
In vitro
In viVo
Lower
Eukaryotes
Plants
Insect.
.
Non-human
Numan
Nonhuman
fluman
D G
+ +
DGCA{i
+1+
DGJCA
+j+i
DOCk
+
DOS$CATI
+++ + +
DGSNCT A?I
++ I —
DIOSNCADL
+1
DGSNCA
D, DNA damages C, gene mutationi C, chromosomal aberrations, 8, sister chromatid .xchangesp A,
aneuplotdy, T,- cell transformatton, DL, dominant lethal M. mioronual.i, R, mttotto
recombination or gene conversions I, inhibition of intercellular countcation, *Mjcronuclej (plants)
-------
BEflZOUI)PYflEflE
50-32-8
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6-
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2-
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-------
I
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55 55 0
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OH IF I
Pr ( WOT S LOI iU(RWOT PL T W CTS
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BEflZO(fl)PVREflE
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A
6. -
4.
2.
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-------
8ENZO(A)PYRENE
50-32-8
9-JUL-87 PAGE 12
NB. TEST END
RESULT RESULT
DOSE REF EMIC
SHORT CITATION
PLOT
CODE POINT NO ACT ACT (HID/LED) NLJ4BER NIJ4BER
1 PRB
D
0
•
0.3000
157
23508
MOREAU. BAILONE & DEVORET 3700, 1976
2 PRB
B
0
+
15.0000
2521
43495
HO & NO 532, 1981
3 PBS
B
0
-
200.0000
3336
40950
TNO4SON 224, 1981
4 Ed.
0
0
•
250.0000
184
31449
ROSENKRANZ & POIRIER 873. 1979
5 ERD
0
0
•
80.0000
1428
48782
MAMSER, BRYSON, KATZ 135, 1983
6 ERO
D
-
•
10.0000
228
24635
ICHINOTSUBO, MOWER, 52111FF 53, 1977
7 ERO
B
-
+
4.0000
1588
40947
T ATS 199, 1981
8 850
0
0
+
1.3000
892
41826
MCCA&ROLL, KEECH & PIPER 607, 1981
9 SAF
6
0
+
12.5000
505
50813
VITHAYATHIL, MCCLURE, MYERS 33, 1983
10 SAF
6
0
•
1.0000
4408
31969
(ROEN, lUTES & THILLY 4152, 1979
11 SAD
6
0
+
2.5000
84
31926
BRUCE & MEDDLE 319, 1979
12 SAD
6
0
•
2.3000
111
31452
SINBON 893, 1979
13 SAD
6
-
•
1.6000
638
52195
NAWORTM, LAWLOR, MORTEU4AMS 3, 1983
14 SAD
C
-
•
1.5000
1597
40960
RICHOLD & JONES 314, 1981
15 SAD
6
-
•
0.5000
1598
60959
NAGAO & TAKAKASNI 302, 1981
16 SAD
C
-
+
1.0000
1593
40961
ROWLAND & SEVERN 323, 1981
17 SAD
C
0
•
0.5000
2491
37817
HAELLSTR , SUNOVALL, RUNNUG 129, 1981
18 SAO
C
0
•
1.0000
1059
45047
PELROY & STEWART 297, 1981
19 SAD
6
0
+
0.2500
1195
39501
I4ATSUSHINA, SUGIPSJRA, NAGAO 273, 1980
20 5*0
C
0
•
0.1500
1193
39506
NORPOTH, REISCN, HEINECKE 312, 1980
21 SAD
6
-
•
0.5000
155
27123
SINBON, KAUHANEN & TARDIFF 249, 1977
22 5*0
6
-
•
0.3000
1763
58507
DIAIEEL, ZEIGER, BRUSICE 1, 1984
23 SAD
C
-
•
0.5000
6354
60017
SAJCAI, TOSHIBA & MIZUSAKI 61, 1985
24 5*5
6
-
C.)
0.5000
638
52195
NAWOITH, LAWLOR, MORTELMANS 3, 1983
25 SAS
C
0
-
0.0000
111
31452
SINBON 893, 1979
26 5*5
C
-
•
13000
1597
40960
RICHOLD & JONES 314, 1981
27 5*5
6
-
166.0000
1763
58507
BUNKEI., ZEIGER, BRUSICE 1, 1984
28 5 *7
6
-
+
1.2500
1592
40962
SIN ON & SHEPHERD 333, 1981
29 SAT
6
-
C ,)
150.0000
1597
40960
RICHOLD & JONES 314, 1981
30 SAT
C
-
•
0.5000
638
52195
NAWORTN, LAWLOR, MORTELMAMS 3, 1983
31 SAT
C
0
•
2.5000
111
31452
SINBON 893, 1979
32 5*7
C
-
•
0.3000
1763
58507
DUNKEL, ZEIGER, BRUSICE 1, 1986
33 SM
C
-
•
1.5000
1597
40960
RICHOLD & JONES 314, 1961
34 5*8
6
0
•
2.5000
84
31926
BRUCE & MEDDLE 319, 1979
35 SM
G
-
•
50.0000
186
31449
ROSENKRAJIZ £ POIRIER 873, 1979
36 SM
6
0
•
2.5000
111
31452
SIP N 893, 1979
37 SM
C
-
•
0.5000
1763
58507
DIJNKEL, ZEIGER, BRUSICK 1, 1984
38 5*9
0
0
-
2.5000
111
31652
SIPUON 893, 1979
39 SA9
G
0
•
03000
887
41662
NO, CLARK, JERIN 335, 1961
40 5*9
6
0
•
2.5000
86
31926
BRUCE & MEDDLE 319, 1979
41 SA9
C
-
•
1.2000
2147
40954
BROOKS & DEAN 261, 1981
42 SA9
C
-
•
0.5000
638
52195
HAWORTN, LAWLOR, MORTELMANS 3, 1963
43 5*9
0
0
•
0.2500
2899
45712
LEVIN, YAMASAKI, AMES 315, 1982
44 5*9
6
0
•
1.6000
1181
48002
ARIMOTO, NAKAHO,OKARA 105, 1982
45 SA9
C
-
•
0.6000
1600
40955
NARTIRE, VRICELLA, PERFIJ O 271, 1981
46 SA9
6
0
•
0.5000
2491
37817
HAELLSTROI, SUMDVALL, RUNNUG 129, 1981
47 SA9
C
-
•
1.5000
1597
40960
RICHOLD & JONES 314, 1981
45 5*9
6
0
•
500000
2142
60956
GARNER, WELCH & PICKERING 280, 1961
49 5*9
6
-
+
10.0000
1393
40967
GATEHQJSE 376, 1981
SO SA9
G
-
•
0.5000
1763
58507
BUNKEL, ZEIGER, BRUSICK 1, 1984
-------
BENZO(A )PYRENE
50-32-8
HR. TEST END RESULT RESULT DOSE REF EMIC
C00E POINT NO ACT ACT (HID/LED> NUMBER NUMBER
SHORT CITATION
9-JUL-87 PAGE 13
PLOT
51 SA9
0
0
•
0.6000
709
50706
BROOKS, HUTSON, WATSON 225, 1983
52 SA9
C
-
•
0.5000
4354
60017
SAKAI, YOSHIDA & MIZUSAKI 61, 1985
53 SAS
C
0
•
0.0000
111
31452
SIP 4ON 893, 1979
54 SAS
C
0
•
0.2500
2899
45712
LEVIN, YAMASAKI, AMES 315, 1982
55 SAS
C
-
•
0.5000
4354
60017
SAKAI, YOSHIDA & MIZUSAKI 61, 1985
56 ECK
C
-
(+)
50.0000
1589
40968
MOHN, VOGELS-BOUTER & VAN DER 2DM 396, 1981
57 ECW
C
-
•
5.0000
1587
42100
MATSUSHIMA , TAKAMOTO, SHIRAI 387, 1981
58 ECW
C
-
-
166.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1, 1984
59 ECR
C
-
•
0.5000
1587
42100
KATSUSHIMA, TAKAMOTO, SHIRAI 387, 1981
60 SS0
0
•
-
750.0000
1581
40976
SHARP & PARRY 502, 1981
61 SCO
R
•
•
125.0000
1303
50020
KELLY & PARRY 147, 1983
62 5CC
R
-
( •>
51.0000
1422
40972
JAGANNATH, V JLTAGGI0 & BRUSICK 456, 1981
63 5CC
a
•
0
50.0000
1582
40975
SHARP & PARRY 491, 1981
64 SCM
R
-
-
1000.0000
2135
40971
KASSINOVA, KOVALTSOVA, MARFIN 434, 1981
65 SCH
R
-
-
50000.0000
112
31454
51*0W 901, 1979
66 5CR
G
-
-
444.0000
1579
40969
MEHTA & VON BORSTEL 414, 1981
67 SZF
C
•
-
8.5000
2134
40970
LOPRIENO 424, 1981
68 SCM
A
+
•
65.0000
1303
50020
KELLY & PARRY 147, 1983
69 CN
A
•
•
50.0000
1599
40973
PARRY & SHARP 468, 1981
70 15W
C
•
0
10.0000
10082
45839
SCHAIRER & SAUTKULIS 154, 1982
71 TSI
K
•
0
11.4000
10111
58641
MA, HARRIS, ANDERSON 157, 1964
72 0*
C
+
0
252.0000
4407
37188
FAHMY & FAHMY 165, 1980
73 0MX
C
-
0
1260.0000
2554
52277
ZIJLSTRA A VOGEL 243, 1986
74 osx
C
C,)
0
25.2000
1259
48694
VOGEL, ZIJLSTRA, BLIJLEVEN 53, 1983
75 OMX
C
-
0
500.0000
1436
40992
VALENCIA & HQJTCHENS 651, 1981
76 0MW
A
C ’)
0
2520.0000
1259
48694
VOGEL, ZIJLSTRA, BLIJLEVEW 53. 1983
77 DIA
0
•
0
7.6000
532
50841
SIMA, BEAN, DYSART 357, 1983
78 01*
0
0
•
25.2000
2066
52827
BLAKEY & DOUGLAS 141, 1984
79 DIA
0
-
•
7.5000
2386
23583
SUENBERG, PETZOLO & HARBACH 732, 1976
80 DIA
0
-
0
10.0000
4352
54282
LUBET, KISS, GALLAGHER 991, 1983
81 RIA
0
•
0
1.0000
2418
41489
ANORAE & SCHUARZ 187, 1961
82 RIA
0
0
•
25.2000
2066
52827
BLAICEY & DOUGLAS 141, 1964
83 URP
0
•
0
1.3000
740
37980
PROBSY, I4O4AHOW, HILL 11, 1981
84 URP
0
•
0
100.0000
1115
45999
WILLIAMS, LASPIA, OUNKEL 359, 1982
85 URP
0
•
0
250000
4368
41601
TONG, LASPIA, TELAIIG 477, 1981
86 UIA
0
+
0
1.2500
82
21149
CASTO, PIECZYNSKI, JANOSKO 105, 1976
87 UZA
0
C’)
0
0.8000
926
44329
IDE, ISHIKAWA & TAKAYAMA 115, 1981
88 CCC
C
-
+
0.0000
1389
60985
CARVER, SAL .A2AR, KNIZE 596, 1981
890CC
C
0
•
3.0000
1908
37536
PHILLIPS, KRANZ & ELIAS 471, 1980
90 CCC
C
•
•
10.0000
922
45725
GUPTA & SINCH 449, 1982
91 09W
0
-
•
2.5000
723
34289
KUROKI, MALAVEILLE, DREVON 259, 1979
92 G9H
C
0
•
3.0000
181
24465
KRAHN & HEIDELBERGER 27, 1977
93 090
0
0
•
0.1000
4364
27447
SLAGA, HU8ERMAM, SELKIRK 1699, 1978
94 G5T
G
-
•
43000
2138
40964
.JOTZ & MITCHELL 580, 1981
95 GST
C
-
+
2.0000
146
31144
CLIVE, JOHNSON, SPECTOR 61, 1979
96 GST
C
-
•
5.0000
4405
37633
AMACHER & TURNER 485, 1980
97 051
G
0
C.)
3.7500
14.6
31144
CLIVE, JOHNSON, SPECTOR 61, 1979
98 CIA
C
•
0
0.2500
1760
52217
TONG, TELANG & WILLIAMS 53, 1984
99 CIA
C
•
0
2.5000
1636
51682
VED BRAT, TONG, TELANG 474, 1983
100 SIC
S
•
•
0.1000
1586
40982
PERRY & THONSOW 560, 1981
-------
BENZO(A)PYRENE
50-32-8
9-Jul.-87 PAGE 14
MR. TEST END
C00E POINT
RESULT RESULT
NO ACT ACT
DOSE REF EMIC
(HID/LED) NUMBER NUMBER
SHORT CITATION
PLOT
101 SIC
S
•
+
0.2500
1403
50807
BAKER, MITCHELL, MEHER-NONJI 103, 1983
102 SIC
S
0
+
3.0000
1908
37536
PHILLIPS, KRANZ & ELIAS 471, 1980
103 SIC
S
•
.
10.0000
2805
31272
DE RAAT 253, 1979
104 SIC
S
•
+
1610.0000
1595
40981
NATARAJAM & VAN KESTEREN-VAM LEEUWEN 551,1981
105 SIC
S
-
.
1.8800
2143
40980
EVANS & MITCHELL 538, 1981
106 SIR
S
•
0
2.5000
4367
41523
TONG, VED BRAT & WILLIAMS 467, 1981
107 SIS
S
•
0
2.5000
3148
42190
POPESCU, AMSBAUGH, DIPAOLO 71, 1981
108 CIC
C
-
+
500.0000
1595
40981
NATARAJAN & VAN KESTEREN-VAN LEEUWEN 551,1981
109 CIC
C
•
•
500.0000
1919
31275
MATSUOKA, HAYASHI & ISHIDATE 277, 1979
110 C c
C
•
•
126.0000
58
52030
WHIIEHEAD, SAN, SuCH 209, 1983
111 CIC
C
+
0
0.6000
4353
54438
KOCHKAR 845, 1982
112 CI I
C
•
0
10.0000
2144
40983
DEAN 570, 1981
113 TIM
I
+
0
2.5000
480
1024
DUNKEL, PIENTA, SIVAK 1303, 1981
114 TIN
T
+
0
0.5000
4346
SIVAX, CHAREST, RUOENKO 133, 1980
115 1CM
1
•
0
3.0000
4352
54282
LUBE!, KISS, GALLAGHER 991, 1963
116 TCS
T
•
0
2.5000
3148
42190
POPESOJ, AMSBAUGH, DIPACLO 71, 1981
117 TCS
I
•
0
1.0000
1283
49916
AI4ACI4ER & ZELLJADT 291, 1983
116 TCS
I
•
0
0.2500
2503
39667
P011.21, RAINERI, CAVAJIAUGM 323, 1980
119 TCS
I
•
0
1.0000
413
15029
PIENTA, POILEY & LEBHERZ 662, 1977
120 IRA
I
•
0
15.4000
480
1024
DUNKEL, PIENTA, SIVAK 1303, 1981
121 TAR
I
+
0
0.0100
474
FREEMAN, WEISBURGER, WEISIURGER 799, 1973
122 17 5
1
•
0
0.6000
82
21149
CASIO, PIECZYNSKI, JANOSKO 105, 1976
123 TEV
7
•
0
0.5000
676
RAIN, PARE, WEISBUIGER 1167, 1974
124 UHF
0
-
0
252.0000
653
31934
MITCHELL (1976 UNPUB.)
125 UHF
0
0
•
1.0000
2149
40978
AGRELO & AMOS 528, 1961
126 UHF
0
-
•
4.0000
890
42242
AGRELO a SEvERN 151, 1981
127 UHF
0
•
•
10.0000
1594
40977
ROBINSON & MITCHELL 517, 1981
128 UNT
0
-
+
10.0000
1584
40979
MARTIN a NCDERNID 533, 1961
129 UIN
0
-
•
2.3000
836
52152
1%), DING, LI 377, 1983
130 GIN
6
•
•
2.5200
2236
6 1
TONG, FAZIO 1 WILLIAMS 572, 1961
131 GIN
6
-
•
7.5000
2511
40968
GUPTA & GOLDSTEIN 614, 1961
132 GIN
6
•
0
0.0250
4403
37527
ROCCIII, FERRER!, BORGIA 765, 1980
133 BFA
F
•
0
10.0000
656
34279
CONWOR, FORT!, SITAR 269, 1919
134 lEA
F
•
•
100.0000
3061
30829
BAT2INGER, GU & BUEDING 4478, 1978
135 1N
N
-
0
50.0000
2629
GLATI, RUECXER , PLAIT 163, 1985
136 IPSI
H
-
0
495.0000
185
31455
SIJIION, ROSENERAMZ , ZEIGER 911, 1979
137 t WA
0
-
0
100.0000
1055
48204
HIRSALIS, T1SON, 51JTTER% RTH 553, 1982
138 NST
0
•
0
100.0000
4612
26410
DAVIDSON a DAWSON 99, 1977
139 51.0
0
-
0
500.0000
4613
31729
RUSSELL a RUSSELL 1, 1978
140 SVA
S
•
0
13.1000
1601
40995
PAlER, BEMJCIIESISE, RANDALL 673, 1961
141 SVA
S
•
0
450.0000
4361
30879
ROSZINSEY-KOCHER, BASLER a ROIIRBORN 65, 1979
142 W .
N
•
0
30.0000
577
40996
KIRKKART 696, 1961
143 WWA
N
-
0
500.0000
86
31926
BRUCE & HEDOLE 319, 1979
144 MNW
N
•
0
93.0000
576
40997
SALAIIONE, MEDDLE & KATZ 686, 1981
145 w*
n
•
0
30.0000
575
40999
TSUCIIIMOTO & MATTER 705, 1961
146 DLM
C
•
0
750.0000
2131
6919
EPSTEIN & SHAFNER 385, 1968
147 SPA
•
0
232.0000
736
41000
WYROBEK, GORDON & TCHNAJ(ER 712, 1961
(MO)
148 SPA
•
0
250.0000
54
31926
BRUCE a MEDDLE 319, 1979
(NO)
149 SPA
•
0
100.0000
597
37395
TOPHAM 379, 1980 .
(NO)
150 lID
•
0
0.0040
4305
5883
LESKO, SMITH, TS’O 434, 1968
(NO)
-------
BENZO(A)PYREWE 9-JUL-87 PAGE 15
50-32-8
NR. TEST END RESULT RESULT DOSE REF EWIC SHORT CITATION PLOT
IXOE POINT NO ACT ACT (HID/LED) NUMBER NUMBER
DESCRIPTION TESTC ES IN PHYLOGENETIC ORDER
Prokaryotic systems
PRB a Prophage, induction, SOS repair, DNA strand breaks or crosslinks
Ed. a Escherichia coLt pa t A/W3110-P3478, diff. toxicity (Ltq. susp. test)
ERD a Eschertchia colt rec strains, differentiaL toxicity
BSD a BaciLLus st tiL is rec strains, differentiaL toxicity
SAF a SaLmoneLLa typhineiria, forward mutation
SAO a SatmoneUa typfltmuriia TA100, reverse mutation
SA5 a SaLmonelLa typhimurium TA1535, reverse Imjtaticn
SAT • SalmoneLLa typhiia.,rium TA1537, reverse mutation
SA a SalmoneLla tyhimurii. TA1538, reverse nutatton
SA9 • SaLmoneLla typhimurii..m 1A98, reverse mutation
MS a SaLmonelLa typhi,mjrium (other misc. strains), reverse mutation
ECK • Escherichia coLt (12, forward or reverse mutation
ECU a Eacherichia coLi WP2 uvrA, reverse mutation
ECR a Escherichia colt (other misc, strains), reverse mutation
Lower eukaryotic systems
SW • S cerevisi.e, DNA repair-deficient strains, differentiaL toxicity
SCG a Saccharcmyces cerevisiae, gene conversion
SCII a S. cerevisiae, homozygosis by recoa ination or gene conversion
5CR • Saccharcmyces cerevisiae, reverse mutation
a Schizosaccharcmyc.s pca e, forward mutation
SCM a S.ccharo.yces cerevisiae, .net Loidy
Plant syst
TSM a Tradescantla species, mutation
IS! • Tradescantla species, •icror ucLei
Insect systems
a DrosophiLa metanogaster, somatic mutation (and rec ination)
DMJ( a DrosophiLa metanogaster , sex-Linked recessive Lethal mutation
0M W a Drosophila metanogaster, aneuptaid!
Animal ceLls in vitro
DIA a DNA strand breaks, crossL. or ret damage, animal ceLLs in vitro
RIA a DNA repair excLusive of L S, animaL cells in vitro
URP a UnscheduLed DNA synthesis, rat primary hepatocytes
UIA a Unscheduled DNA synthesis, other animaL cells in vitro
GCO a Gene mutation, Chinese hamster ovary celLs in vitro
G9W a Gene mutation, Chinese hamster L .rg V-79 ceLls in vitro, HPRT
G90 a Gene mutation, Chinese hai ter L .sig V-79 ceLls in vitro, ouabain
GST • Gene mutation, mouse L5178Y ceLls in vitro, 1K Locus
G51 a Gene mutation, mouse L5178Y cells in vitro, all other Loci
-------
BENZO(A)PYRENE 9-JUL-87 PAGE 16
50-32-8
GIA a Gene tation, other ammat cells in vitro
SIC — Sister chromatid exchange, Chinese h ter cells in vitro
SIR • Sister chr tid exchange, rat celLs in vitro
SIS • Sister chrosetid exchange, Syrian hter cells in vitro
dC Chro.oso..l aberrations, Chinese hter cells in vitro
dR Chromosomal aberrations, rat cells in vitro
TBM Cal I transformation, BALB/C3T3 mouse eel. Is
TDI Cell transformation, C3N107112 mouse cells
TCS * Cell transformation, Syrian h ter e ryo cells, dlonel assay
TRR CeLl transformation, RLVIFISCHER rat e ryo cells
T7S — Call transformation, SA7/Syrian hster e i-yo cells
TEY a Cell transformat ion, other viral enhancmaent syStama
liLman celLs in vitro
1H4F Urische il.d DNA synth*sis, h r fibrobtasts in vitro
UIIT a lfrische jLed DNA synthesis, transformed himan cells in vitro
UIN Unsch. aled DNA synthesis, other hi.n celLs in vitro
GIN • Gene ..itatlcn, hiaen cells in vitro
Body fluid and host mediated assa
BFA Body fluids fro. animals, microbial ..itagenicity
ISi a $ost mediated assay, •icrobial calls in animal hosts
Animal in vivo
a Unschedslsd DNA synthesis, rat hepatocytes In vive
Nil • Mouse spot test
$1,.O s MOuse specific locus test, other stages
SVA s Sister chr tid exchange, animal cells In vivo
a Micronucleus test, .lc. In vivo
DLM . Qcinsnt lethal test, •ice
Alternative testcodss (not lncLi.obd In profiles)
5PM a Sper . morphology, mouse
5PM a Sperm .orpho&ogy, ss
5PM a Sper. morphology, mouse
BID • Biding (cavalant) to DNA in vitro
EICPOINT I ICATI0NS
o a DNA damage R R.co instlcn G • Gene .itatian S a SCE N a Micronucleus
C a Chr’—’v—e aberration A a Anm. loldy a Cell transformationF a Body fluids N a Nostasdiated assay
-------
BENZO (B ) FLrJOR? 1 NTHENE
Limited data was available for benzo(b)fluoranthene. In a single
study, it caused sister chromatid exchanges in the bone marrow of
Chinese hamsters treated at one dose level. Benzo(b)fluoranthene was
not mutagenic to Salmonella typhimurium TA98 or TA100 in one study.
-------
Compound Benzo(b)fluoranthene
Non—maimna han Systems
N lien $yitms
Proka-
ryotee
lukaryotea
In vitro
In vivo
Lower
Plante
Insects
C
Eukaryotes
DJ C A R
D G CJ
.
DJ 0J CJ
Mon-human
DJ °I NJ CJ AJ ?J I
lumen
DJ 0 J 8J flAJ T J I
lonhuman
DJ ofl M I cj AJDL
Human
DJ 01 1 1 A
1), DHP. damagei C, gene mutations C, chrososomal ab.rrations , si t.r ohro.mtid .zchanqsap A,
aneuplotdy, T,cehl transformatton, DL, dominant lethaip N. aicronuoleti A, aitotic
recombinatton or gene conversjonp I, tnhtbttion of Intercellular aountcation.
-------
BEflZO(B)FLUOflRflTHEflE 9-JUL-87
205—9g-2
8 .— I I I I I
6. —
4.
In
2 —
U) -
In
o O-
L!J
o -
J
—2 —
-4. —
S S
N N
0 0
DI U FM I C I I ‘ I C9.L J
-------
BEflZO(B)FLUORRflTHEflE 9-JUL-B?
205-99-2
I I I I I II
6- —
4- —
Li)
I —
2-
:
w
LA
0
o 0-
L!J
o
J
-2- —
—4- —
S S
a i
P KmVOT S LCI iU( WOT PLaIT ir cts U vrn FM U
N i VITRO Ni
-------
BENZO(R)FLUORANTHENE 9-JUL-87 PAGE 17
205-99-2
NR. TEST END RESULT RESULT DOSE REF ENIC SHORT CITATION PLOT
C00E PCINr NO ACT ACT (HID/LED) NIJIBER NIJ4BER
1 SAO G 0 - 100.0000 4410 31591 MOSSANDA PO* CELET, F .IASSIN 141k 1979
2 SA9 G 0 - 100.0000 4410 31591 H0SSAN0A PONCELET, FOUASSIN 141, 1979
3 SVA S C .) 0 450.0000 4361 30879 R0SZINSKY-K0CHER BASLER & ROHRBORN 65. 1979
DESCRIPTION TESTC00ES IN PKYLOGENETIC ORDER
Prokaryot Ic syste..
SAO • Sat.onet La typhi* riia TA100 , reverse .,taticn
SA9 a Sat.onet La typhi rit.. TA9S, reverse jtation
AniL In vivo
SVA Sister chroe.tid exchange, anit celLs in vivo
ENDPOINT INDICATIONS
D a DNA d gs I • Reccabination 0 • Gene Ritation S • SCE H • MicronucLeus
C • Chro.,sce. aberration A a Ans . Loidy T • C ML tranafore.tionF a Body fLuids a Host.edlated assay
-------
BENZ (A) ANTHRACENE
Benz(a)anthracene induced sister chromatid exchanges and micronuclei
in single studies with Chinese hamsters. Chromosomal aberrations were
increased in bone marrow cells in Chinese hamster but not in rats in single
stud.ies. In a single study, chromosomal aberrations were induced in the
oocytes of mice. No increase in aneuploidy was observed in the same
cells and no increase in aberrations occurred in the spermatogonial
chromosomes of Chinese hamsters. Unscheduled DNA synthesis was not
induced in human fibroblasts in vitro but was induced in ifeLa cells in
one study. No increase in mutation occurred in human cells in vitro .
DNA strand breaks did not occur in use C3H/1OTI/2 fibroblasts in a
single study. Benz(a)anthracene induced unscheduled DNA synthesis in
rat hepatocytes but not in rat tracheal epithelial cells in a single
study. Conflicting results were reported for induction of gene mutation
in in. MnI 1ian cells in vitro . Sister chromatid exchanges were induced in
animal cells in vitro ; conflicting results were reported for chromosomal
aberrations in in si,tm*lian cells in vitro . Benz(a)anthracene did not
induce aneuploidy in one study in Syrian hamster embryo cells in vitro .
Benz(a)anthracene induced transformation of ‘lian cells in vitro .
Sex—linked recessive lethal mutations were not induced in Drosophila
melanogaster . conflicting results were obtained in Escherichia coli
for prophage induction and differential toxicity. Benz(a)anthracene
induced mutations but not recombination in bacteria. It did not induce
micronuclei in plants in one study.
-------
Compounl Benz(a)antbracene
Non—mauu a1ian Systeaa
Naslian 8yat.
Proka-
ryotea
Eukeryotee
,
In vitro
In Viva
Lower
lukaryotes
Plants
-__________
Insects
Ion-human
fltt
$onhuaan
Ilum&fl
D 0
+
DGCAR
OGICIA
).,1
DOCA
-
DO
? 1
BNCATI
+ I
DOINCATI
I -
DO
3JMCADL
+11+1?
DGSNCA
D DNA damages G, gene mutations C, chromosomal ab.rrations 0 . uist.r chrosatid sxchanqes A,
aneuploidy, T,.cell transformation, DL . dominant l.thal N. aioronuol.is R, mitotic
recombination or gene convereton I, inhibition of intercellular cosminication.
-------
BEflZUI)flflTHnqCEflE g-JUL-B7
66-55-3
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56-65-3
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-------
BENZ(A)AMTNRACENE
56-55-3
9-JUL-87 PAGE 18
MR. TEST END
C00E POINT
RESULT RESULT DOSE REF EMIC
NO ACT ACT (HID/LED) NUMBER NUMBER
SNORT CITATION
PLOT
1 P*B
0
0
-
33.0000
157
23508
MOREAU, BAILONE & DEVORET 3700, 1976
2 PQB
0
0
•
50.0000
2521
43495
NO & NO 532, 1981
3 ECL
D
0
-
250.0000
186
31449
ROSENKRANZ 4 POIRIER 873, 1979
4 ERD
0
+
•
0.0000
4351
52500
DE FLORA, ZANACCHI, CAMOIRANO 161, 1984
5 SAP
0
0
•
14.8000
4408
31969
KAOEN, MITES 4 TNILLY 4152, 1979
6 SAC
0
•
•
5.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1, 1984
7 SAC
0
0
•
10.0000
4358
20689
MALAVEILLE, BAUSCH, GROVER 693, 1975
I SAC
0
0
•
5.0000
150
31457
LEVITT, PELKONEbI, OKET 947, 1979
9 SAD
0
0
•
3.6000
4371
47148
GUTHRIE. ROBERTSON, ZEIGER 1620. 1982
10 SAD
0
0
•
10.0000
4378
23983
COONBS, DIXON & KISSONERGNIS 4525, 1976
11 SAC
0
0
( •)
1.0000
4374
54661
CHIU, PU 4 YANG 562, 1984
12 SAG
0
0
•
2.3000
4397
33855
BARTSC)I, NALAVEILLE, TIERNET 185, 1979
13 SAC
0
-
•
5.0000
4398
34423
PEIRILLI, REM!! & DE FLORA 51, 1980
14 SAC
0
0
+
2.5000
4406
37551
AICUENALYKOVA, ANDREEVA, BELITSKII 502, 1980
15 SA5
G
-
•
166.0000
1763
58507
DUNKEL, ZEIGER. BRUSICK 1, 1984
16 sAS
0
0
-
250.0000
4406
37551
ASCUENALYKOVA, ANDREEVA, BELITSKII 502, 1980
17 SAT
0
-
-
166.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1, 1986
18 SAT
0
-
(4)
5.0000
4398
34428
PETRII.LI, REM!! & DE FLORA 51, 1980
19 SAl
0
.
•
17.0000
1763
58507
D(JIKEL, ZEIGER, BRUSICK 1, 1986
20 SM
C
-
(•)
25.0000
111
31452
SIMBON 893, 1979
21 SM
C
( )
5.0000
4398
34428
PETRILLI, REM!! & GE FLORA 51, 1980
22 SAl
0
0
•
50.0000
4406
37551
AIOb*HALYKOVA, ANDREEVA, BELITSICII 502, 1980
23 SA9
C
-
•
5.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1, 1984
24 549
C
0
•
10.0000
709
50706
BROOKS, *JTSON, I ATS0N 225, 1983
25 $49
C
-
+
25.0000
111
31452
SIMBOSI 893, 1979
26 5*9
0
-
•
5.0000
4398
34428
PETULLI, REM!! & 08 FLORA 51, 1980
27 SA9
0
0
•
25.0000
4406
37551
A8DUKI4ALYKOVA, ANOREEVA, BELITSKII 502, 1980
2$ EOV
C
•
.
166.0000
1763
58507
DUNICEL, ZEIGER, BRUSICK 1, 1986
29 5CC
SI
-
0
0.0000
4311
8881
ZIMBERN*NN 65, 1969
30 SCM
B
-
-
50000.0000
112
31454
SINISON 901, 1979
31 T SI
N
-
0
114.0000
10111
51441
MA, HARRIS, ANDERSON 157, 1984
32 0MB
0
-
0
685.0000
4407
37188
FAIISY & FANNY 165, 1980
33 osu
C
-
0
2280.0000
4331
17181
PAMBY & FANNY 2354, 1973
34 0 5CC
C
-
0
799.0000
2554
52277
ZIJLSTRA & VOGEL 243, 1984
35 DIA
0
-
0
22.8000
1995
32858
FCRMACE & LITTLE 704, 1979
36 i. p
0
-
0
228.0000
2
24869
WILLIAMS 1845, 1977
37 UMP
D
•
0
230000
4368
61601
TONG, LASPIA, TELlING 477, 1981
38 t*P
0
•
0
114.0000
740
37980
OSST, MOIAHOSS, HILL 11, 1981
39 UZA
0
-
0
0.2000
926
44329
IDE, ISSIIKMSA 4 TAKAYAMA 115, 1981
40 09W
C
-
0
7.0000
4316
11075
ISIJBERMAX, ASPIRAS, HEIDELIERGER 3195, 1971
41 09W
C
-
10.0000
4336
17796
HIJBERMAN 4 SACHS 326, 1974
42 09N
0
0
•
3.0000
4347
50965
RAVEN 4 NUBERMAN 499, 1983
43 09W
C
0
.
1.0000
4396
35697
WIGLEY, NE ! 0L0 , AMOS 691, 1979
44 09W
0
-
0
10.0000
4396
33852
MARCCMRDT, BAKER, TIERWEY 540, 1979
45 090
0
0
(•)
10.0000
4364
27447
SLAGA, SIJBERMAN, SELKIRK 1699, 1978
46 GST
0
0
(•)
9.8000
715
37387
AMACHER, PAILLET, TURNER 447, 1980
47 C5T
C
0
20.0000
4379
48668
AMACHER S PAILLET 77, 1983
48 OST
C
-
•
5.7000
6405
37633
AMACHER & TURNER 485, 1980
49 01*
0
-
0
21.0000
1636
31612
VED BRAT, TONG, TELANC 474, 1983
50 CIA
C
-
0
2.3000
4391
36626
TONG, FAZIO , TELANG 407, 1980
(NO)
( 540)
-------
BE HZ (A ) AKIN RACENE
56-55-3
9-JUL-87 PAGE 19
MR. TEST END
C00E POINT
RESULT RESULT DOSE REF EMIC
MO ACT ACT (KID/LED) NLJ4BER NUMBER
SHORT CITATION
PLOT
DESCRIPTION TESTC00ES IN PHYLOGENETIC ORDER
Proksryot ic systems
PBS a Prophags, inóictlon, SOS repair, DNA strand breaks or crossLlr*s
Ed. • Eacherichis cot! pot A/U3110-P3478, dlff toxicity (Liq. susp. test)
ERD * Escherlchia cot! fec strains, differentiaL toxicity
SAF * SaLmoneLLa t hi.iri , forward itat1on
SAO • SaLmoneLLa t phi iriia TA100, revers, .Jtstion
SA5 • SaLmoneLLa typhi irita TA1535, reverse jtatlon
SA7 a SaLmoneLLa typhi jrit. TA1537, reverse itation
SAl a SaLmoneLLa t’yphiim.,ri a TA1538, reverse *itation
5A9 a Satmon.L La t ’phiiie rita TA9I, reverse sutation
ECW a Escherichia coti !2 uvrA, reverse jtstion
Lower eukaryotic systems
SCO a Saccharomyces cerevislee, gene conversion
SCM — S. cerevisise, homozygosis by recou tination or gene conversion
51 SIC
S
+
0
2.0000
4369
41885
PAL 389, 1981
52 SIR
S
( )
0
22.8000
4367
41523
TONG, VED BRAT & WILLIAMS 467, 1981
53 CIC
C
+
0
0.6000
4353
54438
KOCHHAR 845, 1982
54 CIS
C
-
0
6.0000
4324
12815
BENEDICT, GIELEN & NEBERT 435, 1972
55 AlA
A
-
0
6.0000
4324
12875
BENEDICT, GIELEN & NEBERT 435, 1972
56 IBM
T
(+)
0
4.0000
480
1024
DUNKEL, PIENTA, SIVAK 1303, 1981
57 TCS
T
C.)
0
10.0000
4321
12001
DIPAOLO, DONOVAN & NELSON 2958, 1971
5$ TCS
I
C.)
0
6.0000
4324
12875
BENEDICT, GIELEN & NEBERT 435, 1972
59 TCS
I
-
0
10.0000
4327
13997
NUSERMANN, KUROKI, MAROIJARDT 1391, 1972
60 TCS
I
•
0
0.1000
473
15029
PIENTA, POILEY & LEBHERZ 642, 1977
61 1PM
I
-
•
1.0000
4326
13788
MARQUARDT & HEIDELBERGER 721, 1972
62 TCI.
I
(+)
0
10.0000
4396
33852
P4AROUARDT, BAKER, TIERNEY 540, 1979
63 TRR
I
•
0
3.0000
480
1024
DIJMKEL, PIENTA, SIVAK 1303, 1981
64 TRR
T
•
0
10000
474
FREEMAN, WEISBURGER, WEISBURGER 799, 1973
65 UHF
0
-
0
100.0000
4328
14328
STICK & SAN 155, 1973
66 UHF
0
-
0
0.0000
132
21394
SAM & STICK 284, 1975
67 UNT
0
0
•
0.0200
1
29113
MARTIN, MCDERMID & GARNER 2621, 1978
68 GIN
G
0
-
10.0000
4356
65123
ALLEN-HOFFNANN & RHEINWALD 7802, 1984
69 GIN
0
-
0
0.2000
4403
37827
ROCCNI, FERRER!, BORGIA 765, 1980
(NO)
70 HMM
H
•
0
1600.0000
185
31455
SIII 0N, ROSENKRANZ, ZEIGER 911, 1979
71 SVA
S
C.)
0
450.0000
4361
30819
ROSZINSKY-KOCHER. SASLER & ROHRBORN 65, 1979
72 MVC
N
•
0
9000000
4402
37248
PETER, PALIE & ROHRBORN 199, 1979
73 CU
C
•
0
50.0000
4332
17569
SUGITAI A 637, 1973
74 CU
C
•
0
900.0000
4402
31241
PETER, PAINE & RO*4RBCRN 199, 1979
75 COG
C
-
0
450.0000
4402
37248
PETER, PAINE & ROIIRBORN 199, 1979
76 dOE
C
•
0
450.0000
4402
31241
PETER, PAINE & BONRBORN 199, 1979
77 AVA
A
-
0
450.0000
4402
37268
PETER, PAINE & ROHRBORN 199, 1979
75 BID
+
0
0.1000
4306
6155
ALFRED £ DIPAGLO 60, 1968
(NO)
19 BID
-
0
5.8000
4307
7923
MOFPNAMN, LESKO & TS’O 2594, 1970
(NO)
80 BID
•
0
1.0000
4322
12859
KURCEI, HUBERMAM, MARGUARDI 389, 1971
(MO)
81 BID
-
0
1.0000
4394
35697
WIGLEY, NEWBOLD, AMOS 691, 1979
(NO)
-------
SENZ(A)ANTHRAcENE 9-JUL-87 PAGE 20
56-55-3
PLant systees
TSI a Tradescantia spectes, micronuctei
Insect syst
Diif a DrosophiLa metanogaster, sceatic *itation (arid recoabination)
DM5 a DrosophiLa aetanog.ster, sex-Linked recessive LethaL *itation
Anit ceUs in vitro
DIA a DMA strand breaks , crossi.. or ret. damage , animaL ceLls in vitro
LRP a f cheó 1ed DMA synthesis, rat primary hepatocytes
LIlA a ( che ited DMA synthesis, other ani.t ceLLs in vitro
69* a Gene ..itatlon, Chinese ht,r Lis g V-79 cit La in vitro, NP*T
a Gene .itation, Chinese hamater L..tig V-79 cit L a in vitro, ouabain
651 a Gene .gation, .ouse LS17SY ceLLs in vitro, TE Locus
61* a Gene tation, other animal cuLts In vitro
SIC • Sister chr tid exchange, Chinese hter cit La in vitro
51* • Sister chrctld exchange, rat ceLls in vitro
CIC a Chr somaL aberrations, Chinese hter ceLLs In vitro
C 5 a Chr— ., & aberrations, Syrian hter celLs in vitro
AlA a Ane Loidy, anlt ceLls In vitro
T9N a CeLL transformation, IALR/C3T3 mous. ceLls
TCS • Cit t transformation, Syrian hter ryo cit Ls ctcn.t assay
TPM a Cit I transformation, mause prostate cit La
ICI. a Cit I transformation, other estabt ishud cut I tines
TIM a Cell trw8formatian, SLV/FISCIIES rat . ryo ceLLs
N..n ceLLs in vitro
1 . 1 W a (kusch.ó4.d DMA synthesis, hi. i ftbrobtasts In vitro
NT a tP ischeójted DNA synthesis, transformed h*a.n caLls In vitro
GIN a Gene tatlon , h .i cit La In vitro
Sody fLuid arid host mediated assays
1111 a lost madistsd assay, microbial cat La In animal hosts
Anit in vivo
SVA a Sister clirc..tid exchange, animaL cit Ia In vivo
a Nlcrorsicteia test, hters In vive
CIA a Chroans L aberrations, an$.sl bone marrow cut La in vivo
C a CI ir s t aberrations, spermetogonia treated In vivo and genie abs.
a Chr ’—e t aberrations, oocytes or uabrycs treated in vivo
AVA • Anetçtoidy, animaL cut La in vivo
Atternstive testeodes (not incLuded In profiLes)
RID a striding (covaLent) to DMA in vitro
RID a Striding (covalent) to DMA fri vitro
RID a Striding (covaLent) to DMA in vitro
RID • Binding (covaLent) to DMA in vitro
E POIIT IICICATIONS
-------
r c.
v .: ’ BE ILRH MID BE LLItM 4 JNDS
No data were available ai the genetic and related effects of
beryllium and beryllium caTix lrx3s in ht tans.
All of the available experinental studies sidered by the Workirs
Grcxxp were carried cut with water-soluble beryllium salts. In a ie
study, beryllium sulphate increased the freq ency of d rQrcsa al
aberratior s and sister chratntid exc anges in htman lyn *ccytes and in
Syrian han ter cells in vitro . Beryllium sulphate caused norplological
transforn tion of cultured lian cells in a variety of test system.
Beryllium thloride induced niitaticx in cultured thinese han ter cells.
Beryllium sulphate did rot induce w sd eduled ttTht synthesis in rat
heçatccytes in vitro . Beryllium sulphate did rot induce mitotic
reanbinatia in yeast in vitro , or nutaticn in bacteria. Beryllium
diloride was iivtagenic to bacteria.
! . oqra *ts , 1, 177 23, l43 l. 4 , 60
-------
— D L&ylaiiz t c& 4 &ith Su p =
--— —
bn-mani 1ian eyet is
Proka- .ikaryotes
ryotea
—---—-%a.a —
Planta insects
— &tea - — — -- — — —
— -___-__---__ —_—__e— —- — -____ - ——-- —_____ - - — —— — — — —
MauMi Ian ayataM
a S ease -r - e- --- -----s- - - -afl——--
in vitro Invivq
- — •as_____ - -
Hon-hunan Ikinan Non-tuinan ftmnn
-— - - — — — — — — — — — — — — — — — —
DO
— C
?
—
A
•
I D
S —
•1
0
C
C
A
D
0
C
A
D
—
I
S
4
+
N
Se
C
#e
i
÷
A
Se
P
÷
I
a
D
0
S
S
a
+
H
C
?
AT
— —
D
3
8
*
H
C
A
Dt
D
Se
3
S
H
C A
— —
U damage; G, gene nutation; C, chra osanal aberrations; S. sister chranatid exchanges; A, aneuploidy, P. cell
transformation, IL, daninant 1etMI H, micronuclet; R, mitotic reocm 1nation or gene cxmversion; I, inh.tbiticn of intercellular
cumunJcati
-------
E3EflVLLIUFfl 9-JUL-B?
7440-41 —7
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9-JUL-87
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BERYLLILI I
7440-41-7
9-JUL-87 PAGE 21
1sAO
2 SA5
3 SAT
6 SA8
5 SA9
6 ECF
7 EcW
8 scn
9 L P
10 09W
11 SIS
12 cIs
13 TBN
14 TRR
15 ics
16 TcS
17 T7S
18 SIlL
19 Ciii.
20 CI II.
21 #
0 - - 166.0000
0 - - 166.0000
C - - 166.0000
C - - 166.0000
O - - 166.0000
O + 0 0.0900
C - 166.0000
I - - 50000000
D - 0 1000.0000
O C .) 0 18.0000
S 0 0.2500
C + 0 0.2500
T • 0 0.0200
T + 0 00050
T • 0 0.3000
I • 0 0.0300
T • 0 5.0000
S • 0 0.2500
C - 0 0.0090
C • 0 0.2500
N - 0 1200.0000
DUHKEL, ZEIGER, 3RUSICIC 1, 1984
DUNKEL, ZEIGER, BRUSICK 1, 1986
DUNKEL, ZEIGER, BRUSICK 1, 1984
DUNKEL, ZEIGER, BRUSICIC 1, 1986
DUNKEL, ZEIGER, BRUSICK 1, 1986
ZAX M & GLICKNAM 9, 1984
DUIKEL, ZEIGER, BRUSICK 1, 1984
SI4ION 901, 1979
WILLIA$S, LASPIA, DtIIKEI. 359, 1982
NITAKI, AKAI4*TSU, ONO 259, 1979
LARRAIENDY, POPESOJ, DIPAOLO 597, 1981
LARRAIEP T , POPESCU, DIPACLO 597, 1981
DUNKEL, PIENTA, SIVAX 1303, 1981
DUNKEL, PIENTA, SIVAK 1303, 1981
PIENTA, P0 11EV & LEBHERZ 642, 1977
DIJIICEL, PIENTA, SIVAIC 1303, 1981
CASTO, lEVERS & DIPACLO 193, 1979
LARRAMEP Y , POPESCU, DIPAOLO 597, 1981
PATON & ALLISON 332, 1972
LARRAIENDY, POPESCJ, DIPACLO 597, 1981
SIIU 0N, ROSENKRAIIZ, ZEIGU 911, 1979
DESCRIPTION TESTCODES IN PNYLOGENETIC ORDER
Prokeryotlc syst
SAD SaLmoneLla t .i.jrl a TAIOO,
SAS a SalmonelLa typhlajrlia TAIS3S,
SAT a Salmonella tp a r4,a TAIS3T,
5*8 a Salmonella t imorl TA1538 ,
5*9 a Salmonella tjr1 TA98, revers . aitatlon
ECF a Escharichfa coti (e,cdtudinq strain K12), fori ard .itation
£04 a Eschericl ia coIl tP2 UVFA, reverse .itation
Lower e Aaryotic systmo
5c)I a $• cerevisia., hcmozygosis by rec ln.tion or gene conversion
Mi1 cells in vitro
URP a W cMô led D MA syntiwsis, rat prlry hepstocytes
09W a Gene itation, Chinese hter t.s g V-79 cells in vitro, NPRT
SIS a Sister chroestid .*change. Syrian hter cells In vitro
CIS a Chr’nso.al aberrat , Syrian htsr ceLLs in vitro
T a c•t I trw sforest ion, BALI/C313 sowea cat Is
1 S a C( I transformot ion, Syrian hamoter ryo cat Is, et onat assay
TU a C.U transfoestlcn, RLV/FISC1IEI rat aabryo eel Is
ITS • CelL transforestlon, SAT/Syrian hter .abryo ceLIa
Ni cells In vitro
$41L a Sister chratid exchange, h I hocytes in vitro
CIII. a Chromosoiuat aberrations, htsn ly ocytes in vitro
MR. TEST EHO RESULT RESULT DOSE REF EMIC
CODE POINT 110 ACT ACT (KID/LED) NIJIBER NIJIBER
SHORT CITATION
1763
1763
1763
1763
1763
3513
1763
112
1115
2000
1003
1003
480
480
473
480
9
1003
3086
1003
185
58507
58507
58507
58507
58507
52342
58507
31454
45999
34022
41
41825
1024
1026
15029
1024
31323
41825
13522
41
31455
PLOT
(NO)
reverse .*atlon
reverse mot.tlon
reverse .jtation
reverse motat ion
-------
Body fluid and host mediated assays
H$S z Host mediated assay, microbiaL ceLLs in animet hosts
ENDPOINT INDICATIONS
D DNA damege R Recontination G Gene ae.ltation $ • SCE N • MicronucLeus
C a Chroniosome aberration A • Anet pLoidy I • CeLL transformationf a Body fLuids H a Hoatmediated assay
-------
V T1’lIU4 AND I 1It14 ctTlPcxlrus 1
People exposed occupaticz a11y to ca nii.in (in an aBcalir -hattery
factory and in the nanufact ze of cadnthmt pigt nts) did not exhibit
ir eased freq iencies of d rcmcsaTa1 aberrati s in their peri * era1
1ynplx cytes. These findings ntrast narkedly with tha positive results
obtained . rkers exposed in zinc e1ting plants and . people
env].rorltentally intoxicated by cac td .in; thase people re also exposed
to other r ,oi dg (see IA , 1976: Lé arl, 1986). In stndy,
sister thrcaetid exthanges re not induced in people exposed to cadmiiin
in the environnent ( k,gav et al. , 1986).
cbnitan tçtx ds have not roduced ir eased frequencies of
th&ui ecma1 aberrations or mtoronuclei in nd ce in vivo nor did they
produce inant lethal effects in nd ce or rats. ( d.tin c i ,ounris
induced an iploidy in haneters bit not in mice treated in vico . c ni
ccnp,x ds induced d roncsaial aberrations bit not sister thra atid
ex&ianges in nenralian cells in vitro and caused u .k logical
trarefornation of cultixed — . lian cells in several test systena.
‘rney i ‘ red _ single—strand breaks in htman and rodent cells in
vitro , and t e j 5 fjj ng evid that they produced nutation in
cultured wnelian cells. Caôniun did not induce aneuploidy or satatic
or recessive lethal nutations in Droeoçfrtila . It induced nd.tctic
rea tination in yeast, bit it did not induce nutatiai in yeast or
bacteria, nor did it induce prq age in bacteria.
! noqra s , 2, 74; 11. 39; iopl. 4 . 71
-------
11 ’8axk
Sub rx*p -
bn-nwmmialian Sy8tet
Hanin 1ian ayst
Proka- Eukaryotes
ryotea -- -
Plante Insects
vttro tnvivc
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Ikinan
Non-hta n an
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D, WA damage; G, gene nutation; C. thran sanal aberrations; S sister chranatid exchanges; A, aneuploidy, T, cell
transfonnation. IL. daiiinant lethab H, micrcnuclei; R, mitotic rea ination or gene cxnversion; I, inhibition of intercellular
aimunicaUon
-------
C 1D1flIU1fl 9-JUL-B?
7440-43-9
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-------
CADN ILJ4
7 640-43-9
9-JUL-57 PAGE 22
U. TEST END
C00E POINT
RESULT RESULT DOSE REF EMIC
NO ACT ACT (KID/LEO) NIJ BER NLI4BER
SNORT CITATION
PLOT
1 P18
0
-
0
7.2000
1766
52886
ROSSNAN, MOLIMA 4 MEYER 59, 1984
2 5*0
S
-
•
250.0000
84
31926
BRUCE & MEDDLE 319, 1979
3 SA0
S
0
1120.0000
812
41535
TSO & FliNG 195, 1981
4 SAO
S
-
-
1666.0000
10131
63366
MORTELMANS, MA1 RTN, LAWLOR 1, 1986
5 SA2
S
-
0
0.0300
3516
58786
MARZIN & PHI 69, 1985
6 SAS
S
•
-
1000.0000
10131
63366
MORTE1 .MANS , HA RTN , !.AULOR 1, 1986
7 SA7
S
-
•
250.0000
84
31926
BRUCE & HEDDLE 319, 1979
8 sA7
S
-
-
1000.0000
10131
63366
NORTEU4ANS, HAWORTM , LAWLOR 1, 1966
9 sA9
S
-
-
250.0000
86
31926
BRUCE & MEDDLE 319, 1979
10 SA9
S
-
-
1666.0000
10131
63366
MORTELMAMS, NAUORTH, LAWLOR 1, 1986
11 SCO
R
+
0
11.0000
1074
49902
F1 JNAGA, KURACHI, MIZUQJCNI 3017, 1982
12 SCM
S
•
0
34.0000
1074
49902
FUKUNAGA, KURACHI, NIZUGUCH! 3017, 1982
13 DIS
S
-
0
132.0000
3526
60287
RAS*3S0N 157, 1985
14 OMX
S
-
0
0.0000
1263
51309
CHUMS & KIN 55, 1962
15 0 10!
S
-
0
112.0000
1996
32964
KOGAN, GROZDOVA, K)IOL IKOVA 1486, 1978
16 D II !
S
.
0
50.0000
1969
30176
INGUE & WATANABAE 153, 1975
17 DI I I
A
-
0
62.0000
2001
34221
lAME!. & NAGNUSSOSI 59, 1979
18 D III
a
-
0
112.0000
1996
32964
KOGAiI, GROZDOVA, (HOLIKOVA 1484, 1978
19 DIA
0
•
0
3.4000
532
50841
SIU, BEAM, DYSART 357, 1963
20 DIA
0
•
0
2.2000
651
50940
CC III & OSISAWA 69, 1963
21 DIA
0
•
0
4.5000
2040
52075
0CM!, ISHIQJRO. ONSAWA 169, 1963
22 GCO
S
(•)
0
0.0000
83
31301
NSIE, O’NEILL, SAN SEBASTIAN 293, 1978
23 S9M
S
•
0
0.1000
651
50940
0CM! & ONSAWA 69, 1963
26 G5T
S
-
0
0.0700
809
37075
AMCNEI I PAILLET 279, 1960
25 SIC
S
-
0
0.0450
314
37263
DEAVEN & CAMPBELL 251, 1980
26 SIC
S
-
0
0.5000
939
45292
011*10, NANACKA, YAMADA 141, 1962
27 CIC
C
•
0
0.1120
316
37263
DEAVEII & CAMPBELL 251, 1960
28 dC
C
•
.
0
11.2000
1969
22344
ROSIN & SAUCHINGER 125, 1976
29 CIT
C
-
0
3.6000
175
31682
IJIEDA & NISNIIBJRA 221, 1979
30 TCS
T
•
0
0.1000
15
502
DIPAOLO & CASTO 1005, 1979
31 TCS
T
(•)
0
0.5000
3672
67549
RIVEDAL & SANNER 2950, 1961
32 115
1
•
0
0.2300
9
31323
CASTO, MEYERS 4 DIPAOLO 193, 1979
33 DIN
0
-
0
6.0000
1076
45434
MCLEAN, WILLIAMS, KAPI.AN 137, 1962
34 DIN
0
•
0
50.0000
1418
54207
CASIO 629, 1953
35 DIN
0
•
0
2.5000
1977
26804
ZASUICIIIMA, SINELSNC14!KOVA 409, 1976
36 SIlL
S
-
0
0.0100
3755
20028
BECK 4 BRIJBAEER 181, 1975
37 CII I
C
(+)
0
11.2000
2012
41606
GAS!OREK & BAUCHINGER 513, 1961
35 CML
C
.
0
5.6000
1967
29104
DEKW T & QEMINATTI 67, 1978
39 IIV
IS
•
0
0.0300
911
44106
BISNUN & PENTECOST 29, 1961
40 W Ml
N
-
0
9.1000
84
31926
BRUCE & NEDOLE 319, 1979
41 .
N
-
0
50.0000
901
45028
WATAJIASE, 10110*, )IAYASHI 43, 1982
42 CSA
C
-
0
72.0000
1999
34009
DEK* T & GERBER 163, 1919
43 CCC
C
0
1.5000
679
21323
SILLIA D 4 LEONARD 43, 1975
44 DIM
C
-
0
1.8000
316
46522
BUlL & LEVERENZ 399, 1980
65 DIM
C
0
1.0000
679
21323
GILLIA & LEONARD 43, 1975
46 DIN
C
-
0
4.3000
414
12964
EPSTEIN, ARNOLD, ANDREA 268, 1972
67 01*5
C
0
1.2000
512
40179
POSSERAIITSEVA, RAMAIYA & VILKINA 1397, 1980
4$ DLII
C
0
2.4000
1978
24822
RAMAIYA, PONERANTSEVA 43, 1917
49 DIM
C
-
0
2.4000
1965
21292
SUTER 365, 197’S
50 DLI
C
-
0
10.0000
315
38222
SUTOU 4 YAMAIIOTO 51, 1960
(NO)
(NO)
(NO)
(NO)
(NO)
(NO)
($0)
-------
CADNILJ 9- UL 87 PAGE 23
7440-43-9
MR. TEST END RESULT RESULT DOSE REF ENIC SHORT CITATION PLOT
CODE POINT NO ACT ACT (HID/LED) MIJ4BER MtJ 8ER
51 AVA A 0 3.7000 1990 30493 WATANABE, SHIMADA, ENDO 472, 1977
52 AVA A • 0 1.2000 1993 31779 WATANABE, SHIMADA, ENDO 349, 1979
53 SI.H S - 0 0.0010 3671 65740 MOGAWI, ISURITANI, TAMADA 283, 1986 (NO)
54 CI.H C (+) 0 0.0000 633 18217 0EKNt T, LEONARD a IVANOV 132, 1973
55 CLH C C ,) 0 0.0000 635 21991 DEKNL T & LEONARD 319, 1975
56 CLH C C-) 0 0.0040 1528 53216 FLEIG. RIETH, STOCKER 106, 1983 (NO)
57 CU4 C C ’) 0 0.0000 634 21945 BAUCHINGER, SCHMID, EIHBRODT 57, 1976
DESCRIPTION TESTCODES IN PHYLOGENETIC ORDER
Prokaryot Ic systema
PRB • Prophage, in .ictfon, SOS repair, DNA strand breaks or crossLinks
SAO a SaLmonella typhi..irua TAIOO, reverse %Itation
5*2 a Salmonella typh irI .a TAIO2, reverse .itation
SAS a SalmonelLa typhi jri.. TA1535 , reverse atation
SAT • Salmonella typh mori*a TA1537 , reverse .Jtat on
SA9 a Salmon, L La typh i iri TA9S, reverse itat ion
Lower .ukaryotic systewe
SCG a Saccharo.yces c.revisia,, gene conversion
SCR * Saccharomyc.s c.r.visia., reverse jtation
Insect systema
a Drosoç,hILa metanogaster, somatic mjtation (and rec ination)
OIC( a Drosophila melanogaster, sex-Linked recessive lethal atation
DMN a DrosophiLa metanogaster, an. toidy
Animal cells in vitro
DIA a DNA strand breaks, crosal. or ret. dme.ge, animal celLs in vitro
OCO a Gene .itat1on, Chinese h ster ovary cells in vitro
0911 a Gene ltat ion, Chinese hter l sug V-79 cells in vitro, HPRT
5T a n, *jtatlon, mouse L5178Y cells In vitro, TK Locus
SIC a Sister chr tId exchange, Chinese hter cells in vitro
CIC a ChromosomaL aberrations, Chinese hter cells in vitro
CIT a Chro.os l aberration., transformed cells in vitro
Ics a Cell transformation, Syrian hamat.r abryo cells, clonel assay
175 a Cell transformation, SAT/Syrian h t.r eabryo cells
Hus.n cells in vitro
DIN * DNA strand breaks, crosst. or ret. d g., htn cells in vitro
SilL a Sister chromatid exchange, husen Ly hocytes in vitro
CHL a Chromosomal aberrations, ht L hocytes in vitro
Body fluid and host mediated assays
IBIA a HoSt mediated assay, animal cells in aniuml hosts
-------
CADMIUN 9 -4Ut.-87 PAGE 24
7440-43-9
Ani t in viva
N W a Micronucteus test, mice in viva
C3A a Chromoso( berrat ions, anit bone asrrow cetts in vivo
CGC a Chro.osc t aberrations, spertogonia treated in viva and cytes abs.
DIN • Dominant LethaL test, mice
DIR • Dominant LethaL test, rats
AVA • Anet Loidy, ani.sL ceLLs in viva
lKn in viva
a Sister chr tid exChange, tn sn Ly hocytes in viva
CL I I a Chroanso L aberrations, hiaw L ocytes in viva
EIC#OINT 1NDICATI IS
D a 0 11* d ge R a Rscothin.tian G a Gene eutation S a $CE N a MicronucLeus
C a Chromoso aberration a • Me Loidy T a C• ( transfortionF • Body fLuids N a Hostuediated assay
-------
° ‘ DO tZT CITE OR QU2TE
No data were available on the genetic and related effects of
chloroform in humans.
Chloroform did not induce micronuclei in ne—uarrow cells or
D ti T’ ge in liver or kidney cells of rats. tr ated in v vo . tt did not
induce throixcsomaj. aberrati . s, sister z tid exchanges! Q
unscheduled ! Th synthesis in human lyir cytes in vitro . Chloroform
enhanced virus-induced cell. tr sformati c) y ian hamster embryo
cells. It did not induce sister iatid exd2sges or mutation in
Chinese hamster cells or Ct 1ns t t hepatocyt in vitro
Chloroform did not induce• reces ikè ethài M thtionS in Dros iila or
aneuploidy, t: seq tioft ir : pergiUus nidulans .
Chloroform indu .& E ri ’ 4 l it not t*ut tion, aneuploidy, ml.totic
rec bi ia i :or gé r3ioii in. Sacd taroinyces cerevisiae , whereas
mito :i combi t Øn and: qerie conversion were induced in S.
cerevisi e using cond .t i.ons n tich levels of endogenous cytochrome
P450 were Ch.t roform did not induce mutation or ! damage r
bacteria.
4 noqraphs , 1, 61; 20, 401; Suppl. 4 , 87
-------
-- ——
l_ 1J _ - — --
& n-ia nma1Lan .y.tai
jj ayat
Prcl a- 1 ikaryote.
——
YOPL4ntS thaects --
— — e — — • — — — — —— — — —
D GD ; A1 DO C A DO C A
- - --——--- -
—— —---—-
y1tro —
::::: .::::::::.
Nan hu a
— — • .... 114 — a — ... . — e
0 S 14 ( A TI DO MC AT
In vivo
Nan-hL un
S
DO S H C A CL 0 0 S MC
A
.
. -
—— —
—
-—
——
—-
--
—
—
- .
.&
-i:
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‘—
—
“
—
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—
- .—
—
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D WA damage; 0 gene ,iutatian; C. dircza eanal aberr ttone; 5, at rthra dexI a’ A ar pIoidy T. cell
tozu tta , EL dcznin nt Lethal. H, micronuclet; k, mitoLic reu ithatfcE r gene unveraion I, ix hthiti of inter Uu1ar
- - j c -
No.
Subgr ip -
cyldilli nicat1ai
-------
CHLOPOFOflIfl 9—JUL-B?
67-66-3
1151 II H
6- —
4
U i
I —
U i
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-2 A
rn A -
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I r aP t 10 S F H C L I L 10
I I c c I I ° , 1 Tn1m I ‘ “ I ‘- -
-------
CHLOflOFOflIfl
67-66-3
i i i
g-JuL—87
sa a i 0 DUG S U S C D I I I
ni imaa t C D fl O I III I H H H VP U
F Ii) I IPII C 1.1 t. 00 I
$ O VO1 % aJ( YOT $ p mT fl AThQ E% FM m A’ 4Ab1
- I flV tRO
8 -
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0
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I
—4. —
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-------
CHLOROFORM 9-JUL-87 PAGE 25
67-66-3
NB. TEST
ENG
RESULT
RESULT
DOSE REF
EMIC SHORT CITATION PLOT
C00E
POINT
NO
ACT
ACT
(HID/LED) NIJ BER
NUNSER
1 PBS
0
-
-
5.0000
3336
40950
THONSON 224, 1981
2 ECL
0
-
C .)
0.2000
1590
40968
ROSENKRAMZ, NYMAN & LEIFER 210. 1981
3 E
0
-
-
10000.0000
2141
40945
GREEN 183, 1981
4 830
0
-
-
20000.0000
3676
40944
KADA 175, 1981
5 SAF
6
-
0
300.0000
1596
40966
SKOPEK, ANDON, KADE$ 371, 1981
6 SAG
6
-
•
5000.0000
1333
43288
VAN A8BEE, GREEN, JONES 557, 1982
7 SAD
6
0
•
7500.0000
10018
37504
NESTMANN, LEE, MATULA 203, 1980
8 S*0
a
-
-
2500.0000
2126
40957
MACDONALD 285, 1981
9 3*5
6
-
-
5000.0000
1333
48288
VAN A8BEE, GREEN, JONES 557, 1982
10 3*5
6
•
•
5000.0000
1597
40960
RICHOLD & JONES 316, 1981
11 5*5
0
0
-
7500.0000
10018
37504
NESThAMN, LEE, MATULA 203, 1980
12 S*5
a
-
-
10.0000
1393
40967
GATEH JSE 376, 1981
13 5*7
6
-
-
5000.0000
1333
48288
VAN ABBEE, GREEN, JONES 557, 1982
14 SAT
a
-
-
5000.0000
1597
40960
RICHOLD & JONES 314, 1981
15 SA?
6
0
-
1500.0000
10018
37506
NESTHANII, LEE, MATULA 203, 1980
16 SAT
6
-
-
2500.0000
2126
40957
MACDONALD 285, 1981
17 SAT
C
•
-
10.0000
1393
40967
GATEHWSE 376, 1951
18 3*8
0
•
-
5000.0000
1333
48288
VAN ABSEE, GREEN, JONES 557, 1982
19 3*3
a
-
-
5000.0000
1597
40960
RICIIOLD & JONES 314, 1981
20 3*8
6
0
-
7500.0000
10018
31506
NESTM*NN, LEE, MATULA 203. 1980
21 5*9
6
-
•
5000.0000
1333
43288
VAN Miff, GREEN, JONES 557, 1982
22 5*9
0
0
•
0.5000
1193
39506
NORPOTH, REISCH, HEINECU 312, 1980
23 3*9
0
0
•
1500.0000
10018
37504
NESTPANIS, LEE, MATULA 203, 1950
26 5*9
0
-
•
2500.0000
2126
4095?
MACDONALD 285, 1981
25 5*9
6
-
-
10.0000
1393
40967
GATENOUSE 376, 1951
26 ECW
6
•
-
1000.0000
1393
40967
G*TEN JSE 376, 1951
27 ECV
C
-
-
5000.0000
2243
41819
KIRKLAND, ITN, VAN ABBE 651, 1951
28 EC2
6
-
-
5000.0000
2243
41819
KIRKLAND, SMITN, VAN ABBE 651, 1951
29 SW
0
•
.
300.0000
1581
40976
SHARP & PARRY 502, 1951
30 SCG
I
•
0
6400.0000
10035
34332
CALLEN, WOLF A PNILPOT 55. 1980
31 3CC
B
0
-
3000.0000
1583
40914
ZUUERMANN & SCHEEL 481, 1951
32 5CC
N
-
-
1000.0000
1582
40975
SHARP £ PARRY 491, 1981
33 5C C
1
-
-
167.0000
1422
40972
JAGMMATN . WLTAGGIO & BRUSZCK 456, 1981
34 SC M
I
-
-
1000.0000
2135
40911
KASSIMOVA, KONALTSOVA, MARF IN 634, 1981
35 SCM
I
•
0
6400.0000
10035
34332
CALI.EN, WOLF & PIIILPOT 55, 1980
36 ANG
B
•
0
7500.0000
2293
52504
GUALAICI 109, 1984
37 MG
B
•
0
250.0000
3674
58351
CREBELLI, CWTI, CONY! 33, 1984
38 5CR
6
•
0
6400.0000
10035
36332
CALLEN, WOLF & PNILPOT 55, 1980
39 s
a
•
-
1111.0000
1579
40969
NENTA & VON BORSTEL 414, 1981
40 ANF
6
-
0
7500.0000
2293
52504
GUALANDI 109, 19*4
41 SCM
A
-
•
100.0000
1599
40973
PARRY & SHARP 468, 1981
42 ANS
A
-
0
250. 0000
3674
58351
CREBELLI, COil!, CONT! 33, 1984
63 0 KM
0
-
0
6400.0000
10050
41641
C CC X !, KING, ECICHAROT 91 • 1981
44 ONE
C
-
0
3000.0000
1580
40993
VOGEL. BLIJLEVEN, KOITSELIUS 660, 1951
45 01*
0
-
0
357.0000
532
50841
SINA. BEAN, DYSAIT 351, 1953
46 INIP
0
-
0
1000.0000
958
1075
PIENTA & KAWALEK 243, 1981
47 URP
0
-
0
1000.0000
1029
45810
ALTHAUS, LAWRENCE. SATTLER 3010, 1982
41 09%
0
-
0
119.0000
2407
25274
STUROCE 20?, 1977
49 sic
s
0
-
33.0000
2128
33288
WHITE, TAXENISA, EGER 426, 1919
50 SIC
5
0
-
10.0000
1586
40982
PERRY £ THONSON 560, 1981
-------
CHLOROFORM 9-JUL-87 PAGE 26
67-66-3
MR. TEST END RESULT RESULT DOSE REF EMIC SHORT CITATION PLOT
CODE POINT NO ACT ACT ( 1410/LEO) NtJ BER MLJ4BER
51 uS 1396 51844
52 UHL 811 61487
53 SHL 2243 41819
54 CML 2243 41819
55 OVA 2196 29366
S6UPR 1055 48204
57 MVN 576 40997
58 MVI4 575 40999
59 NVM 10050 41641
DESCRIPTION TESTCODES IN PHYLOGEMETIC ORDER
Prokaryotic systems
PRB Prophage, induction, SOS repair, DNA strand breaks or crosslinks
ECI. Escherichia coIl pot A/W3110-P3478, diff. toxicity (liq. susp. test)
ERD Escherichia coti rec strains, differential toxicity
850 a Bacillus sAtitts rec strains, differential toxicity
SAF • SaLmonella ty ie,jrius , forward mutation
SAG SaLmonelLa ty nsjrlta TA100, reverse mutation
SA5 • SalmonelLa t hlusirlta TA1535, reverse mutation
SA7 • Salmonella typhlmurita TA1537, reverse mutation
SM a SalumneL La t h1,m.trha TA1538, reverse mutation
5A9 • SaLmonel La typhimurita TA9B, r.vers. mutation
EC%J • Eacherichia coIl %JP2 uvrA, reverse mutation
EC2 • Escherlchia coIl WP2, reverse na..tatlon
Lower eukaryotic systems
$50 • S. cerevisiae, DNA repair-deficient strains, differential toxicity
SCO • Saccharomyces cerevisi.e, gene co wersion
SCN a 5• cerevisiae, hosozygosis by rec instion or gene conversi on
AND a Aspergi I Lus nidutans, genetic crossing-over
5CR a Saccharca.yces cerevisias, reverse mutation
AMF • Aspergit Lu* nidulans, forward mutation
a Saceharosyces cerevislas, enet LoIdy
AWN a Aspergittus nidutans, anet toidy
Insect systems
0MM • DrosophiLa melanogast.r, sex-linked recessive Lethal n. tation
Animal cells in vitro
DIA a DNA strand breaks, crosst. or ret. d g* , animal cells In vitro
a Unscheduled DNA synthesis, rat primary hepatocytes
0944 a Gene mutation, Chines. hm t.r Itrig V-79 cells In vitro, I4PRT
SIC a Sister chromatid exchange, Chinese hamster cells in vitro
ITS • Cell transformation, SAT/Syrian hamster e ryo celLs
Nin cells in vitro
I + 0 163.0000
D - - 15000.0000
5 0 - 400.0000
C 0 - 400.0000
D 0 400.0000
D - 0 400.0000
N - 0 80.0000
N - 0 90.0000
N - 0 952.0000
HATCH, MAMAY, AVER 1945, 1983
PEROC O & PROOI 213, 1981
KIRKLAND, SMITH, VN ABBE 651, 1981
KIRKLAND, SMITH, VAN ABBE 651, 1981
PETZOLD & SWENBERG 1589, 1978
MIRSALIS, TYSON, BUTTERWORTH 553, 1982
SALM4ONE, MEDDLE & KATZ 686, 1981
ISUCNIMOTO & MATTER 705, 1981
GOCKE, KING, ECKHARDT 91, 1981
UHI. a Unscheduled DNA synthesis, hunen Lyeçhocytes in vitro
a Sister chromatid exchange, hunan lyiiçhocytes in vitro
-------
CMI. z Chromoso L aberrations. h ien Ly ocytes in vitro
Ani ( in vivo
DVA * D NA strand breaks, crossi. or ret. d ge, ani Ls in viva
a UnscI e j(ed DNA synthesis, rat hepatocytes in viva
MVl4 a Nicronucteus test, mice in viva
EI POINT INDICATIONS
D a DMA d ge R a Reco. inatian G a Gene .Jtat ion S * SCE 14 a NicroAjcteus
C a Chroaoso.e aberration A a Anet toidy T a CeLL transformatianF a Body fLuids a Ilo*tmedi*ted assay
-------
!tT14 AND E 1fl14
The genetic toxicity of chr ni .m ccxtçounds has been reviewed
recently (Venitt, 1986). The u rked1y different d nical and biological
pcoperties of trivalent and hexava lent thrcrrtitxn are critical to an
understanding of their genetic toxicity. Trivalent chrcm itmi (Cr11111)
is the nore stable oxidation state, and under physiological ditions
it n y form ccitplexes with ligands suth as nucleic acids, pr teins and
organic acids. Biological ncinbranes are thonght to be inperneable to
CrEill ), althou phag cytosis of particulate CrI:III] can occur.
Hexavalent thrQni*zn (CrEVI]) usually fornie strongly oxidizing chratete
and dithrcaete ions, which readily cross biological n thranes and are
easily reduced under physiological xiitions to CrtIII]. Cr11111
carpcxinds nay be ccntandnated with CrtVI] carçx nds (and vice versa) .
Chrani n CVI )
People occupationally exposed to hexava lent chranium tpounds (in
chronate production ar in electroplating factories) have elevated
incidences of th c csa al aberrations in their peripheral blood
lynp1 cytes; re rts on sister d rcvatid exchange induction are
if]icting. Workers exposed to diraniiin xunds during
stainless—steel welding have nct shc in increased incidences of
chroscscaal aberrations, inicronuclei or sister thrcratid exchanges in
peripheral blood lynphocytes (see Th , 1960; Leonard, 1986; Venitt,
1986).
-------
Hexavalent d trcxnius caused dcxninant lethal ntitaticns, d rrxrosc)1el
aberrations and micrcnuclei in rodents treated in vivo . In ht en cells
in vitro , it caused d raivsci el aberrations, sister thratetid exc!nanges
and tt1 danege. In cultured rodent cells, it induced norphological
transfornetiai, d r tcsa l aberrations, sister throsatid exthanges,
nutation and Lt danege. It s nutagenic and caused t*ThL danege in
bacteria.
O rc nitin till )
No data re available on the genetic and related effects of
trivalent dircinii.xn ccxTçcunds in h*.rans.
There is r cunsistent evidence that ter—solub1.e trivalent
dira!thln has genetic activity. The fevi positive results re obtained
only With doses ahout l tines higher than those of hexavalent dir ti itt
r uired to produce su ± effects.
Qirani*jn III did rct induce mi xoriuclei in hone-iiarr cells of
mice treated in vivo . Conflicting results re obtained for the
induction of d saral aberrations in h xian lyn cytes in vitro , and
neither sister du tetid exthanges r r x sd eduled synthesis s
induced in hu en cells in vitro . Conflicting results re obtained
concerning the inducticn of d ra oscrel aberrations, nutation and sister
dwixetid exchanges in neziralian cells in culture. thrcxni*.in III did rct
induce nutation in bacteria, it it induced T danage.
-------
Insoluble crystalline &ranit.mt oxide (Cr 2 0 3 ) irx uced sister
d raTBtid exthanges and imitation in cultured Qkinese han ter cells,
which were sha n to tain particles of the test u terial.
2, 100; 23, 205; Suppi. 4 , 91
-------
CHRONILJ +3
7440-47-3+3
9-JUL-87 PAGE 27
MR. TEST END
C00E POINT
RESULT RESULT DOSE REF EMIC
MO ACT ACT (MID/LED) HIllIER NIJIBER
SHORT CITATION
I PER
0
+
0
26.0000
1766
52886
ROSSMAN, MOLINA & MEYER 59, 1984
2 PER
D
-
0
87.0000
3733
63624
LLAGOSTERA, GARRIDO, GUERRERO 571, 1986
3 850
D
-
0
130.0000
73
20155
NISHIOICA 185, 1975
4 aso
o
+
0
166.0000
584
30890
NAKAIIJRO, YOSHIKAWA . SAYATO 175. 1978
5 ISO
D
-
0
5200.0000
815
39877
GENTILE, HYDE & SCHUBERT 439, 1981
6 8*0
G
-
-
117.0000
53
30889
PETRILLI S DR FLORA 167, 1978
7 SAD
0
-
-
42.0000
42
25197
PETRILLI & DR FLORA 805, 1977
8 SAD
0
•
-
4000.0000
704
40006
DR FLORA 283, 1981
9 SAD
0
-
0
520.0000
812
61538
TSO & FUNG 195, 1981
10 8*0
G
-
-
45.0000
1185
48946
VENIER, MONTALDI, MAJONE 1331, 1962
11 SAC
0
-
0
24.0000
1406
50697
BIARCHI • CELOTTI, LAIIFRARCHI 279, 1983
12 5*2
0
-
-
515.0000
495
52007
BENNICELLI, CAMOIRAIIO, PETRUZZELLI 1, 1983
13 S*5
0
-
•
42.0000
42
25197
PETRILLI £ DR FLORA 805, 1977
14 5*5
0
-
4000.0000
706
40006
DR FLORA 283, 1981
15 SAS
0
-
0
24.0000
1404
50697
BIAICHI, CELOTTI, LANFRAJICHI 279, 1953
16 8*5
0
-
-
65.0000
1185
45946
VENIER, MONTALDI, MAJONE 1331, 1982
17 SAT
0
-
-
3280.0000
42
25197
PETRILLI & DR FLORA 805, 1977
18 5*7
0
-
-
4000.0000
706
40006
DI FLORA 283, 1981
19 8*5
C
-
-
4000.0000
704
40006
DR FLORA 283, 1981
20 SA8
C
-
0
24.0000
1406
50697
IIANCHI, CELOTTI, LANFRANCHI 279, 1983
21 SAS
C
-
-
45.0000
1185
48946
VEMIER, MONTALDI, NAJONE 1331. 1982
22 5*9
0
-
-
42.0000
42
25197
PETRILLI S DR FLORA 805, 1977
23 8*9
0
-
-
4000.0000
704
40006
DI FLORA 283, 1981
24 8*9
0
-
-
45.0000
1185
48946
VENIER, MONTALDI, MAJONE 1331, 1982
25 8*9
0
-
0
24.0000
1404
50697
SIANCHI, CELOTTI, LANFRAMCIII 279, 1983
26 GC0
C
-
0
42.0000
1404
50697
BlANCH!, CELOTTI, LANFRANCHI 219, 1983
27 09W
0
•
0
50.0000
3730
60858
ELIAS, POIROT, SCHNEIDER 159, 1966
28 SIC
S
-
0
50.0000
323
34473
MAJONE & RENSI 379, 1979
29 SIC
S
-
0
0.4000
250
31947
MACRAE, WHITING & STICH 281w 1979
30 SIC
S
•
0
150.0000
258
36919
LEVIS & MAJONE 523, 1979
31 SIC
S
•
0
32.0000
939
45292
OMNO, NAJIAOCA, YAM*OA 141, 1962
32 SIC
S
0
1.0000
813
37212
KOSHI 39, 1979
33 SIC
S
-
0
50.0000
1155
68946
VENIER, NONTALDI, MAJONE 1331, 1982
36 SIC
S
•
0
9.8000
1494
51539
ELIAS, SCHNEIDER, MlI*T 605, 1963
35 SIC
S
-
0
9.8000
1495
42458
LEVIS $ MAJONE 219, 1981
36 SIC
S
-
0
0.5200
1435
50110
UTERI & NISNIO 227, 1963
37 SIC
S
•
0
52.0000
1404
50697
BIANCHI, CELOTTI, LAJIFRAIICHI 279, 1983
38 SIN
S
-
0
52.0000
1261
48797
MAJONE, MOSITALDI, RONCHESE 33, 1983
39 SIN
S
•
0
52.0000
1404
50697
BlANCH!, CELOTTI, LANFRAJICHI 279, 1983
40 CIC
C
•
0
50.0000
323
34473
MAJONE & RENSI 379, 1979
41 CIC
C
•
0
5.0000
258
36919
LEVIS & MAJONE 523, 1979
42 CIC
C
(+)
0
9.8000
1495
42658
LEVIS & MAJONE 219. 1981
43 CIC
C
(+)
0
50.0000
1185
48946
VENIER, MOSITALDI, NAJOWE 1331, 1982
44 CI I I
C
•
0
50.0000
1185
48946
VENIER, MONTALDI, MAJONE 1331, 1982
45 CIS
C
-
0
3.5000
479
24638
TSUBA & KATO 87, 1977
46 CIT
C
-
0
52.0000
175
31682
IJIEDA & NISMIHIJIA 221, 1979
47 UHF
0
-
0
52.0000
1404
50697
BlANCH!, CELOTTI, LANFRANCHI 279, 1983
48 SkI
S
-
0
5.2000
1572
45314
OGAWA, SHINICHI, MORITA 584, 1978
49 SRI
S
-
0
52.0000
1005
45338
STELLA, NONTALDI, *0851 151, 1982
50 CML
C
-
0
130.0000
814
37971
SANTO, LEVIS, PAJJLOSI 239, 1980
-------
CHROMIUM +3 9-JUL-87 PAGE 28
7440-47-3+3
MR. TEST END RESULT RESULT DOSE REF ENIC SHORT CITATION PLOT
C00E POINT NO ACT ACT (HID/LED) NUMBER NUMBER
51 CHL C • 0 2.6000 1005 45338 STELLA, MOIITALDI, ROSS! 151, 1982
52 MVN N 0 49.0000 324 37558 FABRY 889, 1980
DESCRIPTION TESTC ES IN PHYLOGENETIC ORDER
Prokaryotic systems
PRB a Prophage, in ction, SOS repair, DNA strand breaks or crosstinks
a BaciLLus s ti1is rec strains, differentiaL toxicity
SAO a S e Lmonet La typh i .aril.a TA1 00, reverse ILtat ion
SA2 - SaLmoneLLa tyØ i iriia TA1O2, revers• .Jtation
5A5 a Satmon.LL. typfli..iriia TA1535, reverse Imjtation
SA7 a SaLmoneLLa typhiimiri a TA1537 , reverse .. tation
SA8 — Sa Lmonet La typh ijrfsa TA1 538, reverse * tat ion
SA9 a SaLmoneLLa typhiairi a 1A98, reverse tation
AnimaL ceLLs in vitro
GCO a Gene sutation, Chinese h ter ovary ceLLs in vitro
a Gene .Jtation, Chinese h ter Itsig V-79 ceLLs in vitro, NPRT
SIC a Sister chrometid exchange, Chines. h ter ceLLs in vitro
SIN a Sister chromstld exchange, mouse ceLLs In vitro
dc Chromosomet aberrations, Chlnsse hter ceLLs In vitro
CIN a Chromosomat aberrations, mouse ceLLs in vitro
CIS a Chromos L aberrations, Syrian hter c.LLs in vitro
CIT a chromos L aberrations, transfor..d ceLLs in vitro
Ii aan ceLLs In vitro
UHF a Unsch.óited DNA slmthesis, h n fibrobLasts in vitro
SNL a Sister chromatid exchange, h,.men Ly iocytes in vitro
dilL a Chromos L aberrations, h n L hocytes in vitro
AnimeL in vivo
MVN a Microm cLeus test, mice in vivo
ENDPOINT INDICATIONS
D a DNA dm.ege a R.ccthinatlori G a Gene sutation 5 a SCE N a MicronucLeus
C a chromosom, aberration A a Ane Loidy T * CeLL trensformotionF a Body fLuids N a )Iostmediated assay
-------
bi [ O W d&4 LL - — No. _____
Sub3rc*lp -
on-u it Iian systøns
Manunallan Øy8t
Proka- Eukar vtes
ryotea -—
L r Plants Insects
e__ — yts — — — —
Ifl vitro
-— - -— -
tLL Y
Non-hizuan
—- —. —. — -.
Ikm an
— —
Non-h aiian
-— —
Hi.ran
—
D Gfl
;
Al
D
G
C
A
D
0
C
A
S
14
C
A
T
I
D
0
S
14
C
A
T]
D
0
S
M
C
A
DL
D
0
S
II
C A
::
:
:
:
:
:
:
:
:
:
:
:
:
:
::
:
:
:
:
:
:
:
: ::::::
D. WA damage; 0, gene nutation; C, chraa saial aberrations; S. sister chranatid exchanges; A, aneuploidy, T, cell
transformation, IL, daninant lethab 14, micronuclel; R, mitotic re x*th1nation or gene conversion; I, inhibition of intercellular
ammn1cat1a
-------
No. — — — -S
Subgrc* p - -
-— __e— — -
kn-m nii 1ian aye taM
- — —— — -_ .— - — — — —
Manin Iian ayst.eM
—
Ptcka- ikaxyotea
ryotea - --
Lt r Plants Insects
ste —_
In vitro tnvtvq
- -- - -
Non-hunan Htinan Non-hi nan
as Se .5 — e. as .
D GD
;
Al
D
0
C
A
D
0
C
A
D
S
M
C
A
T
I
D
0
S
14
C
AT
D
0
S
N
C
A
I L
D
G
S
14
C
A
:
:
:
:
:
:
:
:
:
:
:
:
:
::
:
:
:
:
:
:
:
D, t*11 damage; 0 gene nutation; C, d rameanal aberrations; S. sister chrmatid exchanges; A. aneuploidy, T, cell
tranafonnation IL. daninant lethab 14, inicronuclel; R, mitotic recc it thation or gene conversion; I, inhibition of intercellular
c.xeuunlcaticm
-------
c norniurn +6
9-JUL-87
7440-47-3+6
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CHROIflIUIfl +6
7440-47—3+6
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-------
CHROMIUM +6
7640-47-3.6
9-JuL•87 PAGE 29
NI. TEST ENO
C € POINT
RESULT RESULT DOSE REF EMIC
NO ACT ACT (HID/LEO) NUMBER tRMBER
SHORT CITATION
PLOT
1 PU
0
+
0
0.2000
1766
52886
ROSSMAN, MOL!NA & PETER 59, 1984
2 P18
D
•
0
1.7000
3733
63624
LLAGOSTERA, GARRIDO, SUERRERO 571, 1986
3 ECO
0
-
0
300.0000
320
31435
NESTMANN, MATULA, DOJGLAS 357, 1979
4 E
D
.
0
0.0000
3831
41642
WARREN, SCHULTZ, BANCROFT 1981
5 SAO
0
•
83.0000
638
52195
NA RTH, LAWLOR, MORTELNANS 3, 1983
6 SAC
0
•
0
6.5000
42
25197
PETRILLI & DE FLORA 805, 1977
7 SAC
B
•
•
4.0000
54
30087
PETRILLLI & 0€ FLORA 139, 1978
8 SAO
S
•
( •)
3.9000
320
31435
NESTK*MN, MATULA, DOUGLAS 357, 1979
9 SAO
G
•
0
2.0000
704
40006
0€ FLORA 283, 1981
10 SAC
B
•
0
520.0000
812
41538
TSO L FUNG 195, 1981
11 SAC
6
•
0
4.0000
495
52007
8ENNICELLI, CAMOIRANO, PETRUZZELLI 1, 1983
12 SAO
o
•
0
0.9000
1404
50691
BIANCHI, CELOTTI, LANFRANCHI 279, 1983
13 SAO
6
•
•
4.0000
1370
53462
PETRILLI a 0€ FLORA 453, 1982
14 SAO
C
•
•
3.5000
1185
48966
VENIER, NONTAWI, MAJOME 1331, 1982
15 5*0
0
•
0
15.6000
3831
41642
WARREN, SCHULTZ, BANCROFT 1981
16 5*2
6
•
•
2.7000
495
52007
BENNICELLI, CANOIRANO, PETRUZZELLI 1, 1983
17 SM
S
.
100.0000
320
31435
NESTMANN, MATULA, DOUGLAS 357, 1919
18 5*5
6
.
2000.0000
704
40006
0€ FLORA 283, 1981
19 SAS
S
•
-
166.0000
638
52195
NN RTN, LAWLOR, MORTELMANS 3, 1983
20 SAS
G
(•)
0
11.0000
54
30087
PETRILLLI & DE FLORA 139, 1978
21 5*5
0
-
-
52.0000
42
25197
PETRILLI & 0€ FLORA 805, 1917
22 5*5
5
-
0
10.0000
495
52007
8€NNICELLI, CAMOIRANO, PETRUZZELLI 1, 1983
23 5*3
6
0
3.5000
1404
50607
IIANCHI, CELOTTI • LANFRANCHI 279, 1983
24 5*5
6
•
-
7.0000
1185
48946
VINIER, MONTALDI, PIAJONE 1331, 1982
25 SAS
S
-
0
10.0000
1370
53462
PETRILLI a DE FLORA 453, 1982
26 SAT
c
(•)
(+
100.0000
320
31435
NESTMANN, MATULA, DOUGLAS 357, 1979
27 SAT
S
-
.
166.0000
638
52195
NAUORTN, LAWLOR, MORTELMMS 3, 1983
28 SAT
C
•
•
13.0000
42
25197
PETRILLI a 0€ FLORA 805, 1977
29 sAT
B
(•)
0
5.4000
54
30081
PETULLLI a DI FLORA 139, 1918
30 SAl
S
(•)
0
0.0000
704
40006
0€ FLORA 283, 1981
31 SAT
5
(•
0
8.0000
695
52007
BENNICELLI. CAMOIRANO, PETRUZZELLI 1, 1983
32 SAl
6
C+)
0
8.0000
1370
53462
PETRILLI & 0€ FLORA 453, 1982
33 SM
S
•
C.)
50.0000
320
31435
NESTMANN, MATULA, DOUGLAS 357, 1979
34 SIB
6
(+)
0
0.0000
704
40006
0€ FLORA 283, 1981
35 518
6
(+)
0
8.0000
495
52001
BENNICELLI, CAMOIRANO, PETRUZZELLI 1, 1983
36 SM
S
•
0
1.3000
1404
50697
BlANCH!, CELOTT I, LANFRANCHI 279, 1983
37 SM
S
•
0
10.0000
1370
53662
PETRILLI & 0€ FLORA 453, 1982
38 5*8
6
•
-
7.0000
1185
48946
VENIER, MONTALDI, PIAJOME 1331, 1982
39 5*9
6
.
•
tde.0000
638
52195
NAI RTN, LAWLOR, MORTELMANS 3, 1983
40 SA9
B
•
0
5.4000
54
30087
PETRILLLI & 0€ FLORA 139, 1978
41 5*9
B
•
0
3.3000
42
25197
PETRILL! & 0€ FLORA 805, 1977
62 SA9
S
(•)
(+)
3.9000
320
31435
NESTMANN, PIATULA, DOUGLAS 357, 1979
43 5*9
6
(+)
0
11.0000
704
40006
0€ FLORA 283, 1981
44 519
6
C.)
0
6.0000
495
52007
BENNICELLI, CAMOIRANO, PETRUZ2ELLI 1, 1983
45 SA9
S
•
•
6.0000
1370
53662
PETRILLI a Of FLORA 453, 1982
46 5*9
5
0
3.5000
1406
50697
BINICHI, CELOTTI, LAJIFRANCHI 279, 1983
47 5*9
6
•
.
3.5000
1185
63946
VINIER, MONTALDI, MAJONE 1331, 1982
48 SA9
B
•
0
13.0000
3831
41642
WARREN, SCHULTZ, BANCROFT 1981
49 5*3
6
•
0
4.0000
1370
53442
PETRILLI & 0€ FLORA 453, 1982
50 SAS
C
•
0
13.0000
3831
41642
WARREN, SCHULTZ, BANCROFT 1981
-------
9-JUL-87 PAGE 30
CHRONIUM +6
7440-47-3+6
SHORT CITATION PLOT
MR. TEST
END
RESULT
RESULT
DOSE
REF
EMIC
C00E
POINT
NO ACT
ACT
(HID/LED)
NUMBER
NUMBER
51 EC
G
-
0
100.0000
320
31435
NESTMANN, MATULA, DOUGLAS 357, 1979
52 ECR
0
+
0
117.0000
1774
56361
KALININA & MINSEITOVA 1525, 1983
53 ECR
0
+
0
166.0000
584
30890
NAKA*JRO, YOSNIKAWA, SATATO 175, 1978
54 ECU
0
•
0
1.6200
320
31435
NESTMANN, I4ATULA , DOUGLAS 357, 1979
55 ECU
0
•
0
125.0000
73
20155
NISHIOKA 185, 1975
56 ECU
0
•
0
1.3000
182
17753
VENITT & LEVY 493, 1974
57 ECU
U
•
0
6.0000
1370
53462
PETRILLI & 08 FLORA 453, 1982
58 EC2
U
•
0
416.0000
73
20155
NISHIOKA 185, 1975
59 EC2
0
•
0
1.3000
182
17753
VENITT & LEVY 493. 1974
60 EC2
U
+
0
0.1000
677
21923
GREEN, P*JRIEL & BRIDGES 33, 1976
61 EC2
G
•
0
8.0000
1370
53462
PETRILLI & DE FLORA 453, 1982
62 SCM
R
+
(+)
62.5000
320
31435
NESTNANN , MATULA, DOUGLAS 357, 1979
63 520
R
•
0
5.2000
3830
22334
BONATTI, HElM! 4 ASBONOANOOLO 147, 1976
66 SCR
U
-
0
520.0000
1074
49902
FUKUNAGA, KURACHI, MIZUGUCHI 3017, 1982
65 DM 14
C
-
0
167.0000
784
52233
ZIM14ERING 907, 1983
66 0MM
A
•
0
167.0000
784
52233
ZIP 4ERING 907, 1983
67 DIA
0
•
0
3.1000
532
50841
SIMA, BEAM, DYSART 357, 1983
68 DIA
D
•
0
0.2600
506
53264
TSAPAKOS, HAMPTON, SINCLAIR 959, 1983
69 0CC
U
•
0
0.0500
1651
52169
PASCHIN, KOZACHENKO & SAL’NIKOVA 361, 1983
70 CCC
U
•
0
0.7000
1404
50697
BIANCHI, CELOTTI, LANFRANCHI 279, 1963
71 G9N
U
•
0
0.0400
996
45113
PASCMIN & KOZACHENKO 367, 1982
72 0914
U
•
0
0.0400
1651
52149
PASCHIN, KOZACI4ENKO & SAL’NIKOVA 361, 1983
73 0914
0
•
0
0.0400
1205
47281
PASNIN, KOZACNENKO, ZATSEPILOVA 64, 1981
74 GST
U
•
(•)
1.2500
3690
67677
MCGREGOR, MARTIN, CATTANACH (IN PRESS)
75 SIC
S
•
0
0.1500
323
34473
IIAJOWE & RENSI 379, 1979
76 SIC
S
•
0
0.0400
250
31947
MACRAE, UNITING & STICH 281, 1979
77 SIC
S
•
0
0.1000
258
36919
LEVIS & MAJONE 523, 1979
78 SIC
S
•
0
0.0400
813
37212
KOSMI 39, 1979
79 SIC
S
•
0
0.0100
939
45292
ONNO, HAIIAOKA, YAIIADA 141, 1982
80 SIC
S
•
0
0.1000
1185
48946
VENIER, NONTALDI, MAJONE 1331, 1982
81 SIC
S
•
0
0.3000
1494
51539
ELIAS. SCHNEIDER, AUBRY 605, 1963
82 SIC
S
+
0
0.0500
1278
64090
MAJONE, MARIN & LEVIS 225, 1962
83 SIC
S
C .)
0
0.0600
1495
42458
LEVIS & MAJONE 219, 1981
84 SIC
S
•
0
0.1000
1406
50697
BIANCHI, CELOTTI, I.ANFRANCMI 279, 1983
85 SIC
S
•
0
0.0010
1435
50110
UTEKI & NISHIO 227, 1963
86 SIC
S
+
-
0.0520
3731
63665
SEN & COSTA 1527, 1986
87 SIN
S
•
0
0.1000
1241
68797
MAJONE, MONTALDI, RONCHESE 33, 1983
88 SIN
S
+
0
0.1000
1406
50697
BIANCHI, CELOTTI, LANFRANCII! 279, 1983
89 CIC
C
+
0
0.1000
258
36919
LEVIS & MAJONE 523, 1979
90 dC
C
•
0
0.1500
323
34473
MAJONE 4 RENSI 379, 1979
91 CIC
C
•
0
0.1000
813
37212
KOSHI 39. 1979
92 CIC
C
C.)
0
0.1000
1185
48946
VENIER, MONTALDI, MAJONE 1331, 1982
93 CIC
C
(+)
0
0.0400
1495
42458
LEVIS & MAJONE 219, 1981
94 CIR
C
•
0
0.4000
3832
60847
NEWTON A LILLY 61, 1966
95 CIS
C
•
0
0.0600
479
24638
TSUDA & KATO 87, 1977
96 CIT
C
•
0
0.0500
175
31682
UMEDA & MISHIMIJRA 221, 1979
97 TBM
T
C.)
0
0.1000
480
1024
DUNKEL, PIENTA, SIVAK 1303, 1981
96 TRR
I
•
0
0.0200
480
1024
DUNKEL, PIENTA, SIVAK 1303, 1981
99 ICS
T
•
0
0.5000
15
502
DIPAOLO & CASIO 1008, 1979
100 TCS
T
•
0
0.0400
679
24438
TSL A & KATO 87, 1977
-------
CHRONIIJ4 +6 9-JUL-87 PAGE 31
7440-47-3+6
NE. TEST END RESULT RESULT DOSE REF ERIC SNORT CITATION PLOT
CODE POINT NO ACT ACT (HID/LED) NUH8ER NUHBER
101 TCS I • 0 0.1000 480 1024 DUNKEL, PIENTA, SIVAK 1303, 1981
102 T7S I (+) 0 10.0000 9 31323 CASTO, MEYERS & DIPACLO 193, 1979
103 T7S I • 0 0.7000 485 44793 CASIO 241, 1981
104 DIN D + 0 26.0000 251 31946 WHITING, STICH & KORAPATNICK 267, 1979
105 0TH 0 • 0 2.7000 991 43342 FORNACE 145, 1982
106 UHF 0 + 0 0.2600 251 31946 WHITING, SuCH & KORAPATNICK 267, 1979
107 UHF 0 - 0 104.0000 1404 50697 IIAJICHI, CELOTTI, LAMFRAMCHI 279, 1983
108 51W + 0 0.0050 250 31947 MACRAE, WHITING & 511CM 281, 1979
109 SHL + 0 0.0030 920 45036 GOMEZ-ARROYO, ALTAMIRANO 425, 1981
110 SIlL S + 0 0.0050 1005 45338 STELLA, MONTALDI, ROSS! 151, 1982
111 SIlL S + 0 0.1000 1572 45314 OGAWA, SNINICHI, NORITA 584, 1978
112 SIN S - 0 0.0000 3678 63654 NAGAYA 129, 1986
113 CHF C + 0 0.0400 250 31947 MACRAE, WHITING & STICH 281, 1979
114 CML C + 0 0.5000 584 30890 NAKAIEJRO, YOSHIKAWA, SAYATO 175, 1978
115 CML C + 0 0.1000 814 37971 SARTO, LEVIS, PAULOW 239, 1980
116 CML C + 0 0.0300 1005 45338 STELLA, NONTALDI, ROSS! 151, 1982
117 NIT G • 0 2.7000 239 37086 KNI SON 66, 1980
118 NW N • 0 6.5000 417 27976 WILD 319, 1978
119 NW N • 0 9.0000 324 37558 FAIRY 839, 1980
120 NW N + 0 0.3500 1536 50145 PASCMIN & TOROPZEV 419, 1982
121 NVC N • 0 2.7000 1578 63787 KATHS SOP, 1981
122 CIA C ‘ 0 0.7000 1205 47281 PASHIN, KOZACHENKO, ZATSEPILOVA 64, 1981 (NO)
123 CIA C + 0 12.0000 3832 60147 NEWTON I LILLY 61, 1986
124 CVA C C c) 0 36.0000 3832 60847 NEWTON & LILLY 61, 1986
125 DLI I C • 0 2.0000 3833 45109 PASCNIN, ZACEPILOVA & KOZACHENK0 345, 1982
126 SLN S • 0 0.0000 1005 45338 STELLA, MONTALDI, ROSS! 151, 1932
127 SW S - 0 0.0400 1610 56626 LITTORIN, HOGSTEDT, S1EO ACK 259, 1983 ($0)
128 WIN N - 0 0.0400 1610 54626 LITTORIN, NOGSTEDT, STRONBACIC 259, 1933 (NO)
129 CLII C - 0 0.0400 1610 54626 LITTORIN, HOGSTEDT, STROISACE 259, 1933 (NO)
130 CLN C - 0 0.0000 3829 49364 IIJSGAFVEL-PURSIANEN, (ALLIONAKI & SORSA 762, 1982
131 CLII C + 0 0.0000 3835 48116 SARTO, CONIMATO, BIANCHI 1011, 1982
DESCRIPTION TESTCODES IN PHYLOGENETIC ORDER
Pro&aryotlc syst
PEE a Praphege, in jct Ion, SOS repair, DNA strand breaks or crosst inks
• Esd*richi. coLT pot A/W3110-P3478, diff. toxicity (spot test)
LEO Esd eric1 is cMl r strains, differentiaL toxicity
SAC St.onet a typhiairia 1*100, reverse ..tt.tion
SA2 a SaLmons! (a tphi. ri 1*102, reverse .,tation
5*5 a SaLmoneLLa typhi a1a TA1535, reverse .atation
SA7 a SaLmoneLLa vypfli.irh TA1537 , reverse ujtation
SM a SaL.on.IL. t ijri TA1538, reverse motation
SA9 a Salmons! (a tYØ%f.jrit TA98, reverse motatlon
SAS a SaLmoneLla typhi*iri (other misc, strains), reverse atation
ECK a Lscherichia coti K12, forward or reverse . tation
ED4 a Escherichf a ceLl 1P2 uvrA, reverse motation
EC2 • Esch.richia coil 1D2, reverse sitation
ECE a Escherlchia coIl (other misc, strains), reverse atat1ofl
Lower e Aaryotic syst
SCM a 5, cerevisiae, hcmozygosis by reco instion or gene conversion
-------
SZG * Schizosaccharomyces po.abe, gene conversion
SCR Saccharomyces cerevisiae, reverse Im.Itation
Insect systens
DM 14 DrosophiLa melanogaster, heritable translocation test
DM14 Drosophila melanogaster, anet loidy
Animal celLs in vitro
DIA DNA strand breaks, croest. or rd. d ge, animal cells in vitro
GCO • Gene eutation, Chinese hamster ovary cells in vitro
0914 a Gene eutation, Chinese hamster Li.mg V-79 cells in vitro, HPRT
GST • Gene .jtation, mouse L51ThY cells in vitro, TK Locus
SIC • Sister chromatid exchange, Chinese hter cells in vitro
SIN • Sister chrometid exchange, mouse cells in vitro
dC • Chromosamsl aberrations, Chinese hamster cells In vitro
CIR • Chromos l aberrations, rat cells in vitro
CIS • Chromoecm.l aberrations, Syrian hamster cells in vitro
CIT • Chromosomel aberrations, transformed cells in vitro
IBM a Cell transformation, ULB/C3T3 mouse cells
ICS • Cell transformation, Syrian hamster eutryo calls, clonal assay
TRR • Cell transformation, RLV/FISCHER rat eu ryo cells
T75 a Cell transformation, SAT/Syrian hamster ryo cells
Ntn cells in vitro
DIN a DNA strand breaks, crossl. or ret. d g., hi..n cells In vitro
UHF * Unsche .jled DNA s ’nthesis, h aan fibroblasts in vitro
SNF * Sister chromatid exchange, ht.n fibroblasts in vitro
SHL a Sister chrom.tld exchange, ht n l hocytes in vitro
SIN a Sister chromatid exchange, other hus.n cells In vitro
CHF a Chromosomat aberrations, husan fibroblasts in vitro
a Chromoscasl aberrations, ht l hocytes in vitro
Animal in vive
NST a Mouse Spot test
MVN • Micronucleus test, mice in vivo
MVC a MicronucLeus test, hters In vivo
CU a Chromos l aberrations, animal bone marrow cells in vivo
CVA * Chromosomal aberrations, other animal cells treated in vivo
DIM • Dominant lethal test, .1cc
H n In vivo
SIN a Sister chrometid exchange, ht.n l hocytes in vivo
SVII • Sister chromatid exchange, ether hussn cells in vivo
MVII • Micronucleus test, ht.man cells in vivo
CIN a Chromosomal aberrations, ht n l hocytes in vivo
ENDPOINT INDICATIONS
0 a DNA damage B • Recoabination G a Gene jtation S • SCE N — Micrors Leua
C a Chromosome aberration A a Anet (oidy T a Cell transformationF • Body fluids N a Nostmediated assay
-------
CHIROIflIUIfl +3
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-------
CRRYSENE
In vivo treatment with chrysene caused, in single studies, weak but
significant increases in sister chromatid exchanges in Chinese hamster
bone marrow cells and chromosomal aberrations in mouse oocytes. it did
not induce chromosomal aberrations in bone marrow cells or spermatogonia
of Chinese hamsters in one study. Chrysene weakly increased gene mutation
in human cell cultures in the presence of an exogenous metabolic system.
Unscheduled DNA synthesis did not result frc in vitro exposure of rat
hepatocytes. Conflicting results were reported in transformation assays
with Syrian hamster embryo cells. In Escherichia coli , chrysene caused
DNA strand breaks in a single study but did not induce differential
toxicity in others. Mutation was induced in bacteria in the presence of
an exogenous metabolic system. In one study in yeast, chrysene did not
enhance mitotic recombi nation.
-------
Compound Chrysene
Non-mammalian Syateme
fl*ali*n 8yst
.
Proka-
ryotee
ukaryotes
In vitro
In vivo
Lower
Eukaryotes
Plants
Insects
Non-human
Human
Non-human
Human
: :
D G CflIR
D G C1A
D G C A
D G S N)CjAfl)I
D G S N1C1A1DL
11111k
D, DNA damage, G, gene mutationi C, chromosomal aberration.i 8, sister chromatid .xchangesi A,
aneuploidy, T,.cell transformation, DL, dominant lethal H. aicronucleit K, *itotic
recombination or gene conversionp I, inhibition of intercellular coimminication.
-------
CHPVSEI1E
218-01-9
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CHRY SE NE
218-01-9
9-JUL-87 PAGE 32
NR.TEST END
COBE POINT
RESULT RESULT
NO ACT ACT
DOSE REF EMIC
(HID/LED) NII4BER NLJ4BER
SNORT CITATION
PLOT
DESCIIPTION TEST ODES IN PIIYLOGEJIETIC ORDU
Proi.ryotic syst
ECI E. coti or (C. coti DNA), strand breaks, crosstinks or repair
Ed. EschericM. coti pot A/ 11O-P3478 , diff. toxicity CLiq. s p. test)
SAF SaLmoneLLa typ 1*iriia , fori .rd .jtation
SA0 x SaLmoneLLa typ lirf TA100, reverse tstion
SAS SalmoneLLa ty,i rita TA1S3S, reverse s,tation
SA7 Satmonet a typhf rItn TA1537, reverse tation
5*8 SaLmoneLla tyØ f aita 7*1538, reverse sstation
5*9 • SalmoneLla t hi.jrha TA9S , reverse .itstlon
SAS s SalmonelLa ty ii.jrl a (other misc. strains), reverse ..atatlon
Lower st aryotlc syst
SC M • S. cerrvlsla., I osozygosis by reco in.t1on or gen, conversion
Animot ceLLs in vitro
1 Ecu
0
0
•
20.0000
4350
52458
OHIA, NAKA*JRA, MORIYA 101, 1984
2 EQ.
0
0
-
250.0000
184
31449
ROSENKRMZ & POIRIER 873, 1979
3 ECL
D
-
0
21.5000
4395
35650
MCCOY, HYMAN & ROSENKRANZ 729, 1979
4 SAF
0
0
•
10.3000
4408
31969
KADEN, KITES & THILLY 4152, 1979
5 5*0
0
-
•
2.5000
4354
60017
SA AZ , YOSNZDA & MI2USA 1 61, 1985
6 SAO
C
0
•
6.8000
4371
47148
GUTNRIE, ROBERTSON, ZEIGER 1620, 1982
7 SAO
C
0
C .)
14.2500
4390
27956
00, LEVIII , RYAN 847, 1977
8 sA0
C
0
C.)
2.5000
4393
35711
AI4OTO, MIZUSAK1, VOSNIDA 1433, 1979
9 SA5
C
-
-
500.0000
111
31452
51 1 14DM 893, 1979
10 SA7
C
-
•
500.0000
111
31452
SI 1 1ION 893. 1979
11 SM
C
-
•
500.0000
111
31452
SINMOSI 893, 1979
12 5*9
C
-
.
2.5000
4354
60017
SAKAI, YOSNIDA & MIZUSAkI 61, 1985
13 SA9
0
0
4300.0000
4395
35650
MCCOY, NYMAI & ROSENKRAMZ 729, 1979
14 SA9
0
0
C.)
5.0000
4393
35711
0(AMOTO , MIZUSAXI, YOSHIDA 1433, 1979
15 SAS
C
-
•
2.5000
4354
60017
5*11*1, YOSHIDA & MIZUSA11I 61, 1985
16 5*5
0
-
-
500.0000
111
31452
SIMMON 893, 1979
17 SCM
R
-
-
50000.0000
112
31454
SIMMON 901, 1979
18 L P
0
•
0
23.0000
4368
41601
TONG, LASPIA, TELANG 477, 1981
19 TCS
T
•
0
10.0000
473
15029
PIENTA, POILEY & LEBHERZ 642, 1977
20 ICS
7
-
0
15.0000
4327
13997
NUIERPIANSI, KUROKI, MAR JARDT 1391, 1972
21 TP$l
7
-
0
10.0000
4325
13787
PIA*OUARDT, KUROLI, HUBERNAM 716, 1972
22 GIN
0
-
C,)
0.9000
4349
52455
NUBERNAM, MCKEO M, JONES 127, 1984
23 GIN
C
-
0
0.2000
4403
37827
ROCCNI, FERRER!. BORGIA 765, 1980
24 1014
N
-
0
330.0000
185
31455
SIPhON, ROSENKRANZ, ZEIGER 911, 1979
25 WA
S
C.)
0
450.0000
4361
30879
ROSZINSICY-KOCHER, BASLER & RONRIORN 65,
1979
26 CIA
C
-
0
450.0000
4375
24688
BASLER, HEROOLD, PETER 249, 1977
27 COG
C
-
0
450.0000
4375
24688
BAStER, HERBOLD, PETER 249, 1977
28 COE
C
C.)
0
450.0000
4375
24688
BAStER, HERBOLD, PETER 249, 1977
(NO)
L*P • LN sche jLed DNA synthesis, rat prinery hepatocytes
TCS • CeLL transformation, Syri en h ter e ryo celLs, c(onsL assay
-------
CHRYSENE 9-JUL-87 PAGE 33
218-01-9
TPN a Cell transformation, mouse prostate cells
Hisian cells in vitro
GIN Gene Illjtation, hunan cells in vitro
Body fLuid ai host mediated assays
H1V • Host mediated assay, microbial cells in animal hosts
Animal in vivo
SVA a Sister chromatid exchange, animal cells in vivo
C8A a Chromosa.sL aberrations, animal bon. marrow cells in vivo
CGG a Chromos t aberrations, sp.rm.togonha treated In vivo and genie abs.
CUE • Chromos l aberrations, oocytes or e ryos treated in viva
ENDPOINT INDICATIONS
a DNA d ge R a Recouu in.tion G a Gene njtation $ a SCE N a Micronucleus
C a Chromosome aberration A a Aneuploidy I a CeLL transformationF a Body fluids N a Hostmediated assay
-------
DIBENZO (A, H) ANTHRACENE
Sister chroinatid exhanges were induced by dibenzo(a,h)anthracene in
one in vivo study in Chinese hamsters. Single studies in human cells
in vitro gave positive results for unscheduled DNA synthesis in HeLa cells
and for gene mutation in EUE cells. Unscheduled DNA synthesis was not
induced in maninalian cells in culture. In m nu lian cells in vitro ,
chroi osomal aberrations, in a single study, and gene mutations were
induced, while sister chromatid exchanges were not induced in a single
study. Ma alian cells in culture were transformed by dibenzo(a,h)anthracene
but conflicting results were seen in C3R10T1/2 mouse cells.
Dibenzo(a,h)anthracene caused differential toxicity and gene mutation in
bacteria in the presence of an metabolic system. Gene conversion was not
induced in Saccharomyces cerevisiae in one study. Conflicting results
were obtained for forward mutation in crease ; one teat for
reverse mutation was negative. In a single study, sex—linked recessive
lethals were induced in Drosophila aelanogaster . Binding to DNA, RNA and
protein was observed in viva and in vitro .
-------
Compound Dlbenzo(a,h)anthracene
Non-mammalian Systems
Naalian Byst.
Proka-
ryotes
ukaryotes
In vitro
In viva
Lower
ukaryotea
Plants
Insects
Non-human
Human
Non-human
Human
D G
+ +
D G C A R
0 G C A
DJG CA
D C
- +
SN C A TI
-‘ + +
DC SM CAT I
+
DO 5 J$ C ADL
1
0GB PICA
0, DNA damage, C, gene mutations C, chromosomal aberrationsp 0, siater chrosatid .xchanqe.p A,
aneuplotdy, T,.cell transformation, DL, dominant lethal, N. *icronucl.ip It, mitotic
recombinatlon or gene convarsion I, inhibition of intercellular communication.
-------
DIBEnZO(R ,H)rnTHnRCEnE
53-70-3
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-------
9-JUL-B?
DIBEflZO(iR.H) 1flTHflRCEflE
53—70—3
I I I I I I II I I
W
ffi
A
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f
I I
IS
II I
(
I
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IW
UI
HI
TN
S
V
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0 lU S
C Al I
I I C
PROK VOT S L * R tJ( VOT PLmT% N CT
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M VITRO W I VH.
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-------
DIBENZO(A , H)ANTHRACENE
53-70-3
9-JUL-87 PAGE 34
MR. TEST END
C00E POINT
RESULT RESULT
NO ACT ACT
DOSE REF EMIC
(HID/LED) NLR4BER MullER
SHORT CITATION
P 1.01
DESCRIPTION TESTC00ES IN PIIYI.OGEIMuTIC ER
Prokaryotic syst
DO a Escherichfa coIl rc strain., diff.reni.I toxicity
ISO • I.cltIi s*.tti(is rec strain., dlffor. t1aI toxicity
SAP * SaL.orietta t hi.jrh , forward tatIon
SAN s 5 5(acfls(($ typiiijrha TA100, reverse tatlon
NAP • Nlcrococct aur.us, forward tation
Lower eticaryotic syst
1 ERD
0
-
•
25.0000
228
24635
ICHINOTSUBO, MOWER, SETLIFF 53, 1977
2 ISO
0
0
•
80.0000
892
41826
MCCARROLL, KEECH & PIPER 607, 1981
3 SAF
0
0
•
21.0000
4408
31969
KADEN, MITES & THILLY 4152, 1979
4 SAD
0
0
•
2.5000
260
37165
BAKER, BONIN, STUPANS 43, 1980
5 SAD
0
0
•
5.0000
150
31457
LEVITT, PELKONEM, OKEY 947, 1979
6 SAO
0
0
•
1.4000
4366
29656
NDOD, LEVIN, THONAS 1967, 1978
7 MAP
0
0
0.0000
4317
11162
CLARK 114, 1953
8 SCG
a
-
0
0.0000
4311
8881
ZIPSIERMANN 65, 1969
9 NCF
0
-
0
250.0000
4302
4932
BURDETTE & HA000X 163, 1954
10 MCF
0
(+)
0
2500.0000
4363
4862
BARRATT & TATIJI 1072, 1958
11 NCR
0
-
0
2500.0000
4302
4932
B*JRDETTE & MADDOX 163, 1954
12 DNX
0
•
0
0.0000
4377
4137
DEIEREC 337, 1948
13 ImP
D
-
0
28.0000
740
37980
P 10 1ST, NCMAHON, HILL 11, 1981
14 UIA
0
•
0
200000
82
21149
CASIO. PIECZYNSKI, JANOSKO 105, 1976
15 UIA
0
-
0
2.8000
926
44329
IDE, ISHIKAWA A TAKAYAMA 115, 1981
16 G91 1
0
-
0
14.0000
4316
11075
II.aERMAN, ASPIRAS, HEIDELBERGER 3195, 1971
17 G9N
0
0
•
1.0000
4348
52395
DIAMOND, CHERIAN, HARVEY 65, 1984
18 0911
0
0
C.)
5.6000
181
24465
KRAMN & HEIDELBERGER 27. 1977
19 051
0
0
•
4.2500
4360
48181
THORNTON, DIAMOND, NIlE 101, 1982
20 SiC
S
-
0
8.0000
4369
41885
PAL 389, 1981
21 Cl i
C
•
0
10.0000
4329
14474
KISLOVA 1398, 1912
22 TIM
I
•
0
0.5000
434.6
SIVAX, CHAREST, RUDENKO 133, 1980
23 TON
I
0
30.0000
4352
54282
LUIET, KISS, GALLAGHER 991. 1983
24 TON
T
(+)
0
20.0000
4345
REZNIKOFF, BERTRAM, BRANKOW 3239, 1973
25 IcS
1
(•)
0
5.0000
4327
13997
UERNAM$l, KUROKI • MARGUAROT 1391, 197’2
26 TCS
I
•
0
0.5000
413
15029
PIENTA, POILEY & LEBNERZ 642, 1977
27 I i i
T
•
0
0.1000
474
FREEMAN, LEISBIJRGER, WEISBURGER 799, 1913
28 TiE
I
•
0
1.0000
4373
CASIO 402, 1973
29 TEV
I
•
0
0.1000
476
IMIN, PARK, WEISBURGER 1167, 1974
30 lINT
D
0
•
2.8000
1
29113
MARTIN, MCDERNID & GARNER 2621, 1978
31 GIN
0
C ,)
0
0.3000
4403
37827
ROCCHI, FERRER!, BORGIA 765, 1980
32 EvA
S
C ’)
0
450.0000
4361
30879
ROSZINSKY-J(OCHER, BASLER & ROHRBORN 65, 1979
33 BID
•
0
0.1000
4306
6155
ALFRED & DIPADLO 60, 1968
(NO)
34 BID
-
0
250.0000
4312
9017
GIOVANELLA, HOCINNEY & HEIDELBERGER 20, 1964
($0)
35 BID
C’)
0
1.0000
4319
11923
EUROKI & HEIDELBERGER 2168, 1971
(NO)
36 BID
•
0
1.0000
4322
12859
JROKI • HUBERPIAN, MARGUAROT 389, 1971
(NO)
37 BID
+
0
0.1400
4323
12874
DUNCAN & BROOKES 369, 1912
(NO)
38 B’ O
•
0
2.0000
4336
18860
BG EN, SLAGA, SNAPAS 2634, 1974
(NO)
39 SW
•
0
2.0000
4336
18860
B EN, SL.AGA, SIIAPAS 2634, 1974
(NO)
60 lIP
C’)
0
1.0000
v.319
11923
KUROEI & NEIDELBERGER 2168, 1971
(NO)
SCO • Saccharo ces cerevisiae, gene conversion
-------
NCF a Neurospora crassa, forward sijtation
NCR a Neurospora crassa, reverse nxjtation
Insect systems
DNX a Drosophila melanogaster, sex-Linked recessive LethaL ns.ltation
Animal cells in vitro
URP • Unscheduled DNA synthesis, rat primary hepatocytes
UIA a Unscheó.zled DNA synthesis, other animeL cells in vitro
G911 a Gene sutation, Chinese hamster Usig V-79 cells in vitro, HPRT
GST a Gene nutation, mouse L5178Y cells in vitro, 1K Locus
SIC a Sister chrometid exchange, Chinese hamster cells in vitro
CIR a Chromos l aberrations, rat cells in vitro
IBM a Cell transformation, BALB/C313 mouse cells
a CelL transformation, C3H1OT1/2 mouse cells
ICR • Cell transformation, Syrian h ter enhryo cells, cLonal assay
TRR a CeLL transformation, RLV/FISCHER rat es ryo cells
I7S a CeLL transformation, SAl/Syrian hamster eabryo cells
1EV * Cell transformation, other viral enhancement systems
Hi.men ceLLs in vitro
UNT a Unscheduled DNA synthesis, transformed htsmn ceLls in vitro
GIN • Gene njtation, h n cells in vitro
Animal in vivo
WA • Sister chromatid exchange, animal ceLLs In vivo
Attrnattve t.stcodes (not Incl,4ed in profiles)
BID a Binding (covalent)
BID a Binding (covalent)
BID a Binding (covalent)
BID a Binding (covalent)
BID a Binding (covalent)
BVD a Binding (covalent)
BVP * Binding (covalent)
BIP a Binding (covalent)
ENDPOINT INDICATIONS
to DNA In vitro
to DNA In vitro
to DNA in vitro
to DNA In vitro
to DNA in vitro
to DNA, animal cells in vivo
to RNA or protein, animal cells in vivo
to RNA or protein in vitro
D a DNA damage B • Reconhinatlon
C a Chromosome aberration A a Anet loIdy
G • Gene .jtatlon S a SCE
I a Cell transformationF a Body fluids
N • Nicrorsicleus
H a Nostmediated assay
-------
&p .M•i4 I
para—DtcO D
DO NOT CITE OR QUDI
No data were available on the genetic ar related effects of
para-di lorobenzene in h .mans.
para-Did lorobenzene was nu.itagenic to fun 9 i i r t to bacteria.
ft qra s , 7, 231; 29, 2 3; Suppi 4 , ç$.
-------
tlon-,wininal 1 .ian Bystalis
-- -- - r ir, v.i
Maim U34 eyst m
.---- 4- - --- .. ..-.- -
Proka- FAlcaryotea
ryotea — -- —
I er
eukaryotes
i n vitro
—-
Ifl’.PivO
—-
Nc )-’bIaJb n
Uui n
Non-hunan
fitinan
— — —
DGfl
———
—. ..
;
—.
-_
A
—
D
•—
—
0
—
—
C
—
—
A
—
—
D
—
—
0
—
•—
C
•—
—
A
——
D
——
S
——
—
14
—
- .
c
S:::.
—
.?
t
•
-
-
-I
::
-
——
()
-—--
t•
0
——
* :
S
.::
—
M+.
H
::::
—
} +
C
—
-.— —
AT D
.
:
0
-
.—
S
-—
—.
14
—
—.
C
—
—
A
—
—
IL
—
—
D
—
—
0
—
—
S
—
—
14
—
— —
CA
———-
!
-——
I.
-
-
—
-—
——
—
——
.——
—
—
:::
:
:.
• •
-_•
.:::
•
:
— -*
;__
—
—
—
—.—
D, WA dainage; 0, gene nutation; C, thra usana1 aberration8 ; S. sister cIW ex * es ; A ar Laidy .
transformation. IL, daninant Letha] H, zaicronuclel; R, mitotic r th4 4pfbØt gez e nversion;: th41ition of intercellular
c4 pLf L L 1Q Q4
No. _____
Subgroup _______
uun cation
-------
DICHLOROBEflZEflE. P- g-JUL--8?
106—46—?
8 —
6. -
4. —
Ln
I-
2
w
In
a 0
L!J
0
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-2
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I ar FM I I ‘ I ° ° ( ED fl1TI
-------
9—JUL-B?
DICHLOIROBEflZEflE, P-
106-46-7
I
I
I
I I I II I I
S
P KRWOT 5 L I J( VOTE I
FM m
mvsTr I mu vo
6•
4.
2
0-
-2-
—4-
LA
I—
c
3
LU
In
0
0
(2
0
-J
A
-------
D CI4LORO8ENZENE. P.
106-46-7
9- uL-8T PARE 35
HR. TEST END
C00E POINT
RESUtT RESULT DOSE REF EMIC
NO ACT ACT (HID/LED) NII 8ER MIJ4BER
SHORT CITATION
PLOT
I SAD 6 - - 3271.0000
25A0 C - - 50.0000
3 SA5 C - - 3271.0000
4 5*5 6 - 50.0000
55*7 C - 3277.0000
6SA7 6 - 50.0000
7 5*8 6 - - 3277.0000
85*9 6 - - 3277.0000
9SA9 C - - 50.0000
10 ARR C • 0 200.0000
DESCRIPTION TESTC ES IN PWVLO HETIC ER
5*0 a S.t n.tLs t *ari TA100 , revere. ..it.t on
S*5 • Satontta t i.jri TA1535, revere. .jtatlon
SAT a Sat n.L (a t i ri TA1537, reverse ..it.tlon
SA l • Satscn.( (a t . ri*a TA1538, revere. sitatlan
SA9 - Sstmon.L (a ty i.jri a TA9S. reverse sitation
Lower eukaryot c syste
ANI • AspsrgiL(us n Lans, reverse tatf on
ENDPOINT INDICATIONS
SI4IMIZU , YASUI, MATSUHOTO 217, 1983
HAWORTH, LAWLOR, MORTELMANS 3, 1983
SHIMIZU, YASUI, M*TSLB4OTO 217. 1983
HAWORTN, LAWLOR, MORTELMAMS 3, 1983
SNINIZU, YASUI, MATS 1JIOTO 217, 1983
HAt RTN , LAWLOR, MORTELMANS 3, 1983
SI4IMIZU , YASUI, MATSUHOTO 217, 1983
SHINIZU, YASUI, NATSLJ4OTO 217, 1983
M*WORTN, LAWLOR, MORTELIWIS 3, 1983
PRASAD 369, 1970
1321
638
1321
638
1321
638
1321
1321
638
2585
48947
52195
48947
52195
48947
52195
48947
48947
52195
5695
Prokaryoti C syst
o 04 1* d gi I • lecc in.tion
C a iron ’s aberration A a AnsI*Lotdy
C a Cans jtstion S • SCE
T • CeLL traisfor tionF a Body fLuids
N • MicronucLeus
N • Ilastasdlated assay
-------
DO OT CITE CR Q 2TE
o data were available on the genetic and related effects of
didtlorc* thane in ht ns.
Did tloromethane did rct induce diroixcsa aL :aberzatia s in rat
ne-uiarr cells or micronucle]. in mice i vivb . Uz dièduled Ct I
synthesis was rx t induced in hun n cells in vitro . It induced
chroizcsonal aberrations, txit r t mutati i or CC A .ti n ge, in 1 L J.ian
cells in vitro ; flicting results were rep,rt for the induction of
sister thrcxatid exchanges n Ch nes hamster ceits. Dichioromethane
induced transformation of vi —j f4 .ted Tirscher rat M Syrian hamster
enüryo cells. it it uc reces let t rroscptiia . it
was iaitagenic iitotic re irbination and
gene conversion in. Sa hart xiyces cerev&s 4 using nditions in which
levels Oereenhariced. It was Iriltagenic to
1 IA !4 qra ths , 2O 449; Suppl. 4 , 111; 41, 43
-------
- ——--a--- -
t-ii m iian .y.taI
--
Proka- Eukaryote.
ryc,t88 —
— ——
.!! ! - -—— f;- --- - ------ -
nm Uian .ayat
- - - -- - -_ -—
fl, !. ittiO — In vivo
. .: : :
— — — — — -, —— — — —-—-— — —— —
.---
-.
D GD
— — —
;
—
AI
•
D
0
C
A
D
0
C
— —
A
D
— —
S
aS
14
t
A
T
j4 4
I
r
D
(
q
S
s
p3
C
AT D
0
S
Se
14
C
A
IL
—
D
—
0
S
—
N
a —
C A
k
— —
j
-1 -
1
—
j
+
4
---
— — —
,-
—
+
•
:::
r
:
::::
e
• 4
:::
4
:::
.
1+
:: :::::
—
:::.
—•
—•
—
—.
-
—
a-
—
—
—
—
(1I damage: 0. gene irutation; C. darQE)GQML aberr ttona; , 8 i : a ; 81 A Qidy T 1 cell
tran.fonu tLan, IL. daaLnant lethal. N, jnicronLclei; k mitotic rexmI,thation or gene cxnveraionl J fl l biticn of intercellular
______ • :::: : :
—____ ____
b.
Subçjrc**p -
-------
DICHLOflornETHç fl 9-JUL-B?
7S—O9-2
I S I 1 : I I I
6-
4-
I—
2-
o ____ ir J t”i ____ _____ _______ _________ ________
-2-
A
1 1 1 1 W I C
11W V 11
I IRR I
I I I I I I ‘ I
-------
In
I—
c
3
III
In
0
a
U
0
-J
DICHL0R0IflETH flE
75-09-2
I I I
555
5
1
1
0
5
C
11
IRA
if
C
S
S
I
I
I
I?
IS A
Al
II
I
C
I
C
C
IS
9—JUL-87
II
I I
8 . —
6. -
4. —
2 —
0
—2
—4.
I
I ’
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I IU
01
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Ni VITRO
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-------
DICHLORONETHANE
75-09-2
9-JUL-87 PAGE 36
NE. TEST END
CODE POINT
RESULT RESULT DOSE REF ERIC
NO ACT ACT (HID/LED) NU4BER NI.I4BER
SNORT CITATION
PLOT
DESCRIPTION TESTCODES IN PNYLOGENETIC ORDER
Prolc*ryotic syst
SM a S.t.onetta typhl.irh TAIOO , reverse .jtatfon
SA5 a Sat.onetta t th iri TA1535, reverse atatlon
SAT a S.l.on.lla t), fJriua TA1537 , reverse tat1on
$48 a SaL.cnelts t ’p tiai T41538, reverse jtatIon
$49 • SaL n.LL. typfli..rha TAgS. revere. *atstlon
Lows? eL*aryotlc syst
SCG • $.ctharcayc cerevisi.., gene conversion
SC M a 5. cerevisise, b zygosis by reco in.ti0n or gen. conversion
SCE • 5.cch.rowyces cerevisi.., reverse t.ticn
Plant system
I SAO
0
+
•
95.0000
10030
50946
GREEN 277 , 1983
2 SAO
6
•
0
14.0000
155
27123
SD ON, KAUHANEN & TARDIFF 249, 1977
3 SAO
0
•
•
19.0000
10028
27967
JONGEN, ALINK & KOEMAM 245, 1978
4 SAO
G
•
•
18.0000
10050
41641
GOCKE, KING, ECKHARDT 91, 1981
5 SAO
6
•
+
2L0000
10026
45903
JONGEM. HARJ4SEN, ALINK 183, 1982
6 SAO
6
•
0
6800.0000
10084
53310
OSTERI4AN-GOLKAR, NUSSAIN, WALLES 121,
1983
7 SAD
6
C .)
C’)
26000.0000
10025
43671
KIRUIN, THO4AS & SIMMOSd 367, 1980
S SAS
6
•
0
14.0000
10054
35603
MCGREGOR 53, 1979
9 SA5
6
C’)
C’)
26000.0000
10025
43671
K IRWIN, INCRAS & SIMMON 367, 1980
10 SAT
0
-
-
26000.0000
10025
43671
KIRWIN, TNO AS & SIII ON 367, 1980
11 548
6
-
-
26000.0000
10025
43671
KIRWIN, THORAS & SIPS4ON 367, 1980
12 5*9
6
+
•
720000
10050
61641
GOCKE, KING, ECKNAROT 91, 1931
13 5*9
6
•
•
19.0000
10025
27967
JONGEN, ALINK & KOEMAN 245, 1978
14 5*9
6
C.)
C’)
26000.0000
10025
43671
KIRWIN, THO4AS & SIMMON 367, 1980
15 SCO
R
+
0
13300.0000
10035
34332
CALLEN, WOLF & PHILPOT 55, 1980
16 SCM
R
+
0
13300.0000
10035
34332
CALLEN, WOLF & PHILPOT 55, 1980
17 SCR
S
•
0
13300.0000
10035
34332
CALLEN, WOLF & PHILPOT 55, 1930
18 TSR
S
•
0
0.1000
10082
45839
SCHAIRER & SAUTKULIS 154, 1982
19 TSC
C
C’)
0
644.0000
10111
55441
MA, HARRIS, ANDERSON 157, 1934
20 0MM
0
•
0
10600.0000
10050
41661
GOCKE, KING, ECKHARDT 91, 1981
21 RIA
D
-
0
2547.0000
10092
59457
AImEM & WOLFF 287, 1983
22 UIA
D
-
0
65000.0000
10027
37950
JONGEN, LOIINAN , KOTTENKAGEN 203, 1981
23 GCO
S
-
0
65000.0000
10027
37950
JONSEN, LOMMAN, KOTTENHAGEN 203, 1981
24 6911
6
-
0
52000.0000
10027
37950
JONGEN, LOMNAIS, KOTTENHAGEM 203, 1951
25 SIC
S
C’)
0
13000.0000
10027
37950
JONGEN, LOMMAM, KOTTENMAGEN 203, 1981
26 SIC
S
-
-
13000.0000
1330
41884
THILAGAR A KII4AROO 361 • 1983
27 CIC
C
‘
•
6500.0000
1330
48884
THILAGAR & KII4AROO 361, 1953
28 TIE
T
•
0
14.0000
10071
384
PRICE, MASSETT & MANSFIELD 290, 1975
29 T75
T
‘
0
0.9000
1396
51844
HATCh, MAMAY, AYER 1945, 1953
30 T75
T
‘
0
330.0000
10073
1056
HATCh, MAMAY, AYER 75, 1982
31 UHF
D
-
0
65000.0000
10021
37950
JONGEN, LOMMAM, KOTTEWNAGEN 203, 1931
32 UNI.
0
-
13000.0000
811
41487
PEROCCO & PRODI 213, 1981
33 RVM
N
-
0
1100.0000
10050
61641
GOCKE, KING, ECICHAROT 91, 1981
36 C3A
C
-
0
2600.0000
10095
55858
BUREK, NITSCNKE, BELL 30, 1984
TSR • Tradescant i a spec fee, *Jtat Ion
-------
TSC Tradescantia species, chromosomat aberrations
Insect systens
DMX DrosophiLa metanogaster, sex-Linked recessive LethaL nutation
AnimaL ceLLs in vitro
RIA DNA repair excLusive of UOS, animaL ceLLs in vitro
UIA • Unsche Led DNA synthesis, other animaL ceLLs in vitro
GCO a Can. nn.atatian, Chinese hamater ovary colts in vitro
G9H • Gene ajtation, Chinese hamater L s g V-79 ceLLs in vitro, HPRT
SIC • Sister chrcmstid exchange, Chinese ht.r ceLLs In vitro
c Ic a Chromosomat aberrations, Chinese hamster cells in vitro
TRR • CeLL transformation, RLV/FISCHE rat eatryo ceLLs
T7S a CeLL transformation, SA7/Syrian hamster eatryo cells
Ht.man ceLls in vitro
UHF a UnscheduLed DNA synthesis, husan fibrobtasts in vitro
UHI • UnscheduLed DNA synthesis, husan Lynçhocytes in vitro
AnimaL in viva
MVN a Micronucleus test, mice in viva
CU • Chromosomat aberrations, ani.sL bone marrow cot La in viva
ENDPOINT INDICATIONS
0 a DNA den.g. a Reco in.tion C • Gene nutation S • SCE N • MicronucLeus
C • Chr osome aberration A a Anet t oi dy T a Cat L transformat i onF • Body fluids H • Hostamedi ated assay
-------
E ET
DI D IN1 DO NOT CiTE CR Q TE
In aie st y, d roia s 1 aberrations were rxt found in peripheral
blood lyup ccytes of v rkers exposed to dieldrin.
Dieldrin did r t induce daninant lethal in mice or
d rxcsanal aberrations in unese han ter onè-narrc% l 11s in vivo
It induced unscheluled synthesis in t nzfori d hu n fi wblasts
it r t in rat hepatocytes It did r t nduce s a le-strand breaks in
Czunese han ter V79 cells. Die] drin i 1n c1 tMtercellular
cc*i” ‘ nicat ion in hun n and xo errt ceU syste .. L did not induce
recessive lethal rmitations izi Ot ii and was r t itagenic to
bacteria. It did r t :induce br ákag of i, ii d
-------
—--—- ———-— ———
ayataus
——— —
M.n Lia I Syat
Eukaryotea
--- . -:i ; -
—
— —- -
In vivo
—
-
— — —
— —
N fl
— - .4 n —
-
— — -— —
— -- — — —
— — — —
;
Al
D
—
G
-
C
-
A
-
D
-
G
—
C
--
A
--
D
—-
-
S
--
H
—
1
—
A
r
I
I
D
G
:::
S
‘.
::
C
.:::
AT D
-
C
::::
S
H
C
4
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EL
D
C
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H
CA
——•—-
—
—
—
—
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——
—
—
———
—
—
.
4 d
.p
j44.
—
..
. ... ..
-
—
C-
No.
Sukxjroup - - -
D WA damage; 0 gene ,aitatia ; C, d1raIo QMl aberrittons; S, at chraâatid exthanges; A. azloi4flqidy. T. cell
tranaform tion, IL. dczninant lethal. H, micronuclei, R, mitotic reooithinatlcn or gene cxinversion( I, thhthition of intercellular
c ’•’.uiicat.icx :: : : : :: ::
-------
DIELDRIfl 9-JUL-87
60-67-1
8—
6 —
4
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A!
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C Ill I R Hl( I ILL
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I FM R C I I ‘ I o m ,a uu J ..*.
-------
OIELDRII1
60-57-1
9-JUL-87
1 I ii , I II l I
E S E 0 OH
C A HC I III
I O 2 X HP
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-------
9-JUL-87 PAGE 37
DES RIPT10N TEST 00ES IN PWVLOGEIIEIIC ORDER
ProUryotlc syst
ECS a E. coIl or CE. cell DMA), strwd breUs, creutinks or rep&r
540 a S.I.onel (a typhi rha TA100, reverse m tstf on
5*5 a SM.cn.t La t hI.jrit.. TA1535 , reverse at.t ion
SAT — SaLmonelLa tyØ i.,rha TA1537 , reverse a.statlon
5*8 a SaL. Mta typiti.riaa TA1538, reverse Jt 5tion
NI. TEST END
C00E POINT
RESULT RESULT
NOACT ACT
DIELDRIN
60-57-1
DOSE
REF
EMIC SHORT CITATION PLOT
(HIDILED)
NGR4BER
NUNBER
I EcS
0
•
0
100.0000
2188
30811
GRIFFIN AND HILL 161, 1978
2 5*0
S
0
-
1250.0000
47
29183
ANDERSON & STYLES 924, 1978
3 5*0
S
-
-
5000.0000
352
21338
MCCANN, CHOI, YMIASAKI 5135, 1975
4 s*o
s
-
•
1500.0000
226
52022
GLATT, JUNG & OESCH 99, 1983
5 SAD
S
-
-
1666.0000
638
52195
NAWORTH, LAWI.OR, MORTELMANS 3, 1983
6 5*0
S
-
-
1000.0000
2184
31436
WADE, MOYER. NINE 367, 1979
7 SAD
S
-
-
190.0000
2308
50918
NISHI IJRA, NISNDRJRA , OSHIMA 305, 1982
8 5*5
6
0
-
1250.0000
47
29183
ANDERSON & STYLES 926, 1978
9 5*5
6
-
-
5000.0000
352
21338
MCCANN, CHOI, YAI1ASA I 5135, 1975
10 5*5
6
-
-
1666.0000
638
52195
HAHORTH, LAWLOR, MORTELMAMS 3, 1983
11 5*5
6
-
-
500.0000
2380
22818
MARSHALL, DOROUGII & SWIM 560, 1976
12 5*7
5
-
-
5000.0000
352
21338
MCCANN, CHOl, YAMASMI 5135, 1975
13 5*7
S
-
0
1500.0000
226
52022
GLATT, JUNG & OESCH 99, 1983
14 SA?
S
-
-
1666.0000
638
52195
NAHORTN, LAWLOR. MORTELMANS 3, 1983
15 SA7
C
•
-
500.0000
2380
22818
MARSHALL, DORWGH & SIJIN 560, 1976
16 5*8
5
0
-
1250.0000
47
29183
ANDERSON & STYLES 926, 1978
17 SAM
6
-
0
1500.0000
226
52022
GI.ATT, JUNG & OESCK 99, 1983
18 SAM
6
-
-
500.0000
2380
22818
MARSHALL, DOROUGN £ SWIM 560, 1976
19 SA9
6
0
-
1250.0000
47
29183
ANDERSON & STYLES 924, 1978
20 5*9
6
•
-
5000.0000
352
21338
MCCANN, CHOI, YAMASAICI 5135, 1975
21 5*9
6
-
-
1500.0000
226
52022
GLATT, JUNG & OESCN 99, 1983
22 5*9
6
•
-
1666.0000
638
52195
NAVOITH, LAWLOR, MORTELMANS 3, 1983
23 SA9
C
-
-
1000.0000
2184
31436
WADE, MOYER, NINE 367, 1979
24 SAD
S
C .)
•
1.0000
2405
25190
MAJ*J AR, MAKARAM, VIGUANTI 184, 1977
25 5*9
6
-
-
190.0000
2308
50918
NISNI*JRA, NISHI*JRA, OSNIMA 305, 1982
26 5*1
6
-
•
500.0000
2380
22815
MARSHALL, DOROUGH & SWIM 560, 1976
27 EC2
S
0
1000.0000
2330
14190
ASW. 00-SMITN, TREVINO, RING 418, 1972
28 0101
6
-
0
10.0000
2130
6618
BElIES & SUM 50, 1969
29 01*
0
-
•
1140.0000
2386
23583
SIIENBERG . PETZOLD A NARBACJI 732, 1976
30 01*
0
0
•
381.0000
2095
43406
S N8ERS 49, 1981
31 ta
0
-
0
190.0000
740
37960
P 10 1ST, MOIANON, HILL 11, 1981
32 690
6
C ,)
0
3.8000
2213
27400
AIlED, LEVIS & HART 369, 1977
33 tINT
0
•
•
0.4000
10079
26451
AIMED, HART & LEVIS 161, 1977
34 1110
N
-
0
50.0000
2368
20236
DEAN, DOAX & SOMERVILLE 317, 1975
35 CU
C
0
60.0000
2368
20234
DEAN, DOAK & SOMERVILLE 317, 1975
36 DLM
C
-
0
26.0000
414
12964
EPSTEIN, ARNOLD, ANDREA 288, 1972
37 DLII
C
-
0
50.0000
2368
20234
DEAN, DOAX & SGERVILLE 317, 1975
38 Cul
C
-
0
0.0000
2368
20234
DEAN, DOAX A SOMERVILLE 317, 1975
39 ICR
•
0
5.0000
3694
66306
KURATA, NIROSO £ LPEDA 217, 1982
40 1CM
•
0
7.0000
3693
66678
WADE, TROSICO, SCHINDLER 525, 1980
41 1CM
•
0
3.0000
3691
66349
ZNONG-XIAJIG, (AVAJIAGN, TROSEO 10, 1966
(NO)
(NO)
(NO)
-------
DIELDRIN 9-JUL-87 PAGE 38
60-57-1
SA9 a SaLmonelLa typhinsirius 1A98, reverse im.Itation
SAS a SalmoneLLa typhium.iriui (other misc. strains), reverse IIIJtatiOn
EC2 Escherichia coti WP2 , reverse Imjtation
Insect systens
DMX * Drosophila meLanogaster, sex-Linked recessive LethaL Atitation
AnimaL celLs in vitro
DIA DNA strand breaks, croest. or ret. damage, animal celLs in vitro
URP • Unsche Led DNA sy,ithesis, rat primary hepatocytes
G9 0 Gene eutation, Chinese h ter lis g V-79 ceLLs in vitro, ouabain
Htamn ceLLs in vitro
WIT Unsche jLed DNA synthesis, transformed husan celLs in vitro
Body fluid and host mediated assays
• Host mediated assay, microbial cells in animaL hosts
Animal In viva
CBA a Chromosomat aberrations, animal bone marrow ceLls In viva
DIM a Dominant Lethal test, mice
Hussn in viva
C1 .N ChromosomaL aberrations, htasn Lyu flocytes in viva
ALternative testeodes (not included in profiles)
IC R a Irthibitian of interceLluLar cc u.a lcation, rodent in vitro
ICH a Irthibitlon of intercellular co.micstlon, hti In vitro
ICR a Irthibition of interceLluLar c .aIication, hus.n in vitro
ENDPOINT INDICATIONS
D a DNA damage R a Rec lnation G a Gene uu.Itation S a SCE N a Micronucleus
C a Chromosome aberration A a Anet Loidy T a CeLL transformetionF a Body fluids H a Kostmediated assay
-------
DIETHYLREXYLPRTHALATE
Diethylhexylpthalate (DEHP) induced dominant lethal mutations in mice
but did not cause unscheduled DNA synthesis, mnicronuclei or chromosoma].
aberrations in other studies in maimnais. In single studies, DEHP did not
induce gene mutation or sister chromatid exchanges in human cells in
vitro . Chromosamal aberrations were not induced in huxiAn lymphocytes
in vitro . DNA damage was not induced in animals in culture as measured
by DNA strand breaks and unscheduled DNA synthesis. DEEP did not induce
gene mutations in ina lian cells except weakly in one conflicting
report of positive results. Conflicting results were obtained for sister
chrausatid exchanges in m* lian celia in vitro . Micronuclei,
chramoecusal aberrations and aneuploidy did not occur in in vitro
treatments of ni.*i a lien cells. Transformation assays were positive except
in one study involving Balb/C3T3 cells. DEEP did not induce gen. mutation
in bacteria. Conflicting results were obtained for gene conversion,
reccusbination and gene mutation in Saccharamycee cereviaiae . One test
for genetic crossing—over in n.idulana was positive. Mosaics
were produced in Drosophila aslanoqaster , but a singl. study for
sex—linked recessive lethals was negative. In a single alian body
fluid assay, D did not induce microbial mutagenicity.
-------
Compound Diethylhexypthalate
t on—mama1ian Systems
MaalLan Sy.t.
Proka-
ryotes
Hukaryotes
In Vitro
In vito
Lower
Eukaryotes
Plants
Insects
Non—human
Human
Non-human
Human
A
D [ 0
D G C A R
D C l A
D A
DII 1 I 1
Dl 04 84 l c
-i °
1 1 1 r
DI 01 5 H Cl
D, DNA damage* G, gene mutation, C chromosomal aberrationet 8, sistsr chromatid .xchange.p A,
aneuploidy, T,.cell transformation, DL, dominant lethal N. nicronuclet, R, mitotic
recombination or gene conversion; I, inhibition of intercellular co inication.
-------
OIETHYLH XYLPHTH11LqTE 9-JUL--a?
117—81—?
8 — I I I I I I I I
6 —
4. f
to
2-
L - --
A — j---k
D I I U I S D 55 II C CCC I I I
IR P F ffi HIC C I %II III IV I INS I I
AP A A S7 I A X TI ll AL Al C AL I A I
I FM __ .t J ‘ I I I i Im I
-------
bIETHVLHEXYLPHTH L TE
117—81—?
g-JuL-87
I I I I I I ‘ii I I
%A
fffl
g46
0
i
I
5
i
C
IT
a
L
11
i
AS
0
L
I
S A AU SIC CA!
C I IA I III I II
51I I A I U irn ARC A Al
P K VO1 LQU 1 IJ(R VOT PLR T$ CT5 I 5 W VITPO
65 C I U I C
IH N F P UI
NIL N N IA
I4.I FM fl
mvrn
8- —
6- —
4-
2-
0-
-2-
—4-
U)
I-
3
U i
In
0
0
I!:J
0
-J
A
A
-------
o IETHYLHEXYLPNTHALATE
117-81-7
9-JUL-87 PAGE 39
NR. TEST E C
O0E POINT
RESULT RESULT DOSE REF EMIC
NO ACT ACT (HID/LED) NIJ BER WJ BER
SHORT CITATION
PLOT
I SA0
0
-
-
2500.0000
1700
59614
REXROAT & PROBST 201, 1985
2 SA0
0
-
•
5000.0000
1699
59613
ZEIGER & KAUORTH 187, 1985
3 uO
o
-
-
2500.0000
1698
59612
MATSUSNIMA, MURAI4ATSU & HARESAKU 181, 1985
4 SAO
0
-
-
5000.0000
1697
59611
BAKER 6 BOMIN 177, 1985
5 V .0
C
-
-
1000.0000
4344
50114
YOSHIKAMA, TANAKA, YAMAHA 221, 1983
6 SAC
6
-
-
4900.0000
4342
50951
KIRBY, PIZZARELLO, LAWLOR 657, 1983
7 5*0
0
-
•
1953.0000
1230
48687
ROBERTSON, SIVARAJAN, ELING 476, 1983
8 sAC
C
-
-
5000.0000
4383
58922
ZEIGER, I4AUORTN, MORTELMANS 213, 1985
9 sA2
C
-
-
5000.0000
1697
59611
BAKER 6 BONIN 177, 1985
10 SA2
C
-
•
2500.0000
1698
59612
MATSJSHIM, JRMATSU & 14A&ESAX1J 181, 1985
11 5*5
C
-
-
5000.0000
1699
59613
ZEIGER & HAHORTN 187, 1985
12 5*5
C
-
-
2500.0000
1100
59614
REXRORT a PROBST 201, 1985
13 5*5
C
-
-
4900.0000
‘342
50951
KIRBY, PIUARELLO, LAWLOR 657, 1983
14 5*5
C
•
-
5000.0000
4383
58922
ZEIGER, HAUORTN, HORTELMANS 213, 1985
15 SAT
C
•
-
2500.0000
1100
59614
REXROAT a PRC*ST 201, 1985
16 SAl
C
•
-
4900.0000
4342
50951
KIRBY, PIZZARELLO, LAWLOR 657, 1983
17 SAT
C
•
-
5000.0000
4383
58922
ZEIGER, NAWORTH, MORTELMANS 213, 1985
18 SA l
C
-
-
2500.0000
1100
59614
REXROAT & P*OBST 201, 1985
19 SAl
C
•
-
4900 . 0000
4342
50951
KIRBY, PIZZARELLO, LAI&OR 657, 1983
20 5*9
0
-
-
2500.0000
1698
59612
NATSUSNIMA, PSJRAMATSU & NARESAIW 161, 1985
21 s*9
C
-
-
5000.0000
1697
59611
BAKER a BONIN ITT , 1985
22 SA9
C
-
-
5000.0000
1699
59613
ZEIGER a H* RTH 187, 1985
23 SA9
C
-
-
2500.0000
1700
59614
REXROAT & PROIST 201, 1985
24 5*9
C
•
-
1000.0000
4344
50114
YOSHIKAWA, TANAKA, YAMAHA 221, 1983
25 5*9
0
-
-
4900.0000
4342
50951
KIRBY, PIUARELLO, LAMLOR 657, 1963
26 SA9
C
-
.
1933.0000
¶230
48687
ROBERTSON, SIVARAJAN, ELING 476, 1963
27 SA9
B
-
-
5000.0000
4363
58922
ZEIGER, IIAHORTH, MORTELMANS 213, 1985
28 SAS
C
-
-
2500.0000
1696
59612
MATSUSHINA, NURAMATSU & HARESAXU 181, 1985
29 5*5
0
•
-
500.0000
1701
59615
uBER 213, 1985
30 SAl
C
•
-
5000.0000
1699
59613
ZEIGER a KAI RTN 187, 1985
31 SAS
B
-
•
5000.0000
1697
59611
BAKER I BONIB 177, 1965
32 ECU
C
-
-
1000.0000
4344
50114
YOSNIKAWA, TANAKA, YAMAHA 221, 1983
33 5CC
R
-
7
1000.0000
1706
59620
INGE-VECNTONOV, PAVLOV, NOSKOV 243, 1985
34 5CC
R
•
•
1541.0000
1708
59623
PEWIA & VON BORSTEL 271, 1985
35 5CC
R
.
-
5000.0000
1707
59622
PARRY a ECICARDT 261, 1985
36 5CC
1
-
•
2000.0000
1703
59617
BROOKS, GONZALEZ, CALVEIT 225, 1985
37 5CC
R
C .)
( )
5000.0000
1702
59616
ARNI 217, 1985
38 SCN
R
c• )
-
200.0000
1702
59616
ARNI 217, 1985
39 $C,
R
7
-
1000.0000
1706
59620
INGE-VECIITONOV, PAVLOV, NOSKOV 243, 1985
40 MG
R
•
0
2465.0000
1711
59626
CARERE, CONTI, CONTI 307, 1985
41 SCF
C
7
-
1000.0000
1106
59620
IMGE-VECHTONOV, PAVLOV, NOSKOV 243, 1985
42 5CR
C
-
-
1000.0000
1106
59620
INGE-VECIITONOV, PAVLOV, NOSICOV 243, 1985
43 SCR
C
-
-
5000.0000
1707
59622
PARRY I ECICAROT 261, 1985
44 5CR
C
-
-
5000.0000
1702
59616
ARNI 217, 1985
45 SC,
C
•
•
1541.0000
1708
59623
I€MTA & VON BORSTEL 271, 1985
66 SZF
C
7
-
5810.0000
1710
59625
LOPRIENO, BONCRISTIANI, FORSTER 297, 1985
47 oies
o
c •)
0
7820.0000
1713
59628
FUJIKAWA, RYO a KONDO 319, 1985
48 0s1
B
(+)
0
782.0000
1712
59627
VOGEL 313, 1985
49 0180
C
C.)
0
78200.0000
1714
59629
WRGLER , GRAF a FREI 325, 1985
50 Ol IN
B
-
0
19.6000
3643
60167
YOON, MASON, VALENCIA 349, 1985
-------
DI ETHYLHEXYLPI4THALATE
117-81-7
9-JUL-87 PAGE 40
Ni. TEST END
CODE POINT
RESULT RESULT
NO ACT ACT
DOSE REF EMIC
(HID/LED) NUMBER NUMBER
SHORT CITATION
PLOT
51 01*
0
-
39100.0000
1718
59633
DOUGLAS. BLAKEY, LIU-LEE 359, 1985
52 01*
0
-
0
3907.0000
1717
59632
BRADLEY 353, 1985
53 URP
0
-
0
10000.0000
1715
59630
WILLIAMS, TONG & VED BRAT 341, 1985
54 URP
0
-
0
3900.0000
1722
59637
PROBST & HILL 381, 1985
55 (liP
0
-
0
391.0000
10040
52793
KORNBRUST, BARFKNECHT, INGRAM 99, 1984
56 ImP
o
-
0
390.0000
4387
56992
BUTTERI RTH, BER E2, SMITH-OLIVER 1329,
1984
57 GST
G
-
-
9810.0000
1744
59660
STYLES, CLAY & CROSS 587, 1985
58 GST
0
-
C ,)
7.5000
1742
59658
OBERLY, BEWSEY & PRO8ST 569, 1985
59 051
0
-
-
4900.0000
1741
59657
MYHR, BOWERS & CASPARY 555, 1985
60 GST
0
7
-
2468.0000
1734
59649
AMACHER & TURNER 487, 1985
61 OST
G
-
-
980.0000
4342
50951
KIRBY, PIZZARELLO, LAWLOR 657, 1983
62051
0
-
-
9810.0000
1744
59660
STYLES, CLAY & CROSS 587, 1985
63 051
0
-
-
200.0000
1737
59652
GARNER & CAMPBELL 525, 1985
64 01*
6
0
-
7751.7998
1751
59666
MATTHEWS, DELBALZO & RUNOELL 639, 1985
65 SIC
S
-
-
3900.0000
1718
59633
DOUGLAS, BLAKEY, LIU-LEE 359, 1985
66 SIC
S
c’
-
5000.0000
1725
59640
GULATI, SABHARWAL & SHELBY 413, 1985
67 SIC
S
(‘)
0
3.9000
690
25199
ABE & SASAKI 1635, 1977
68 SIA
S
-
0
1000.0000
1723
59638
PRISTON & DEAN 387, 1985
69 MIA
N
-
-
3910.0000
1718
59633
DOUGLAS, BLAKEY, LIU-LEE 359, 1985
70 CIC
C
-
-
4130.0000
1726
59641
ISHIDATE & SOFUNI 427, 1985
71 CIC
C
-
•
5000.0000
1725
59640
GULATI, SABNARWAL & SHELBY 413, 1985
72 CIC
C
-
0
50.0000
1724
59639
DAMFORD 397, 1985
73 CIC
C
0
-
0.0000
1719
59634
LAKHANISKY & HENORICXX 367, 1985
71. dc
C
-
0
390.0000
490
25199
ABE & SASAKI 1635, 1977
75 dc
C
-
0
781.0000
4372
48138
PHILLIPS, JAMES & GANGOLLI 297, 1982
76 CIC
C
-
0
160.0000
1876
24895
ISHIDATE & ODASNIMA 337, 1977
77 CIA
C
-
0
1000.0000
1723
59638
PRISTON & DEAN 387, 1985
78 AlA
A
-
0
50.0000
1724
59639
DANFORD 397, 1985
79 TIM
T
.
-
15.6000
1751
59666
MATTHEWS, DELBALZO & RUMOELL 639, 1985
80 1CM
T
C .)
(i)
40.0000
1752
59667
LAURENCE & MCGREGOR 651, 1985
81 YCS
I
•
0
0.8000
1754
59669
SANNER & RIVEDAL 665, 1985
82 ICE
I
•
0
1.0000
1748
59664
BARRETT & LAMB 623, 1985
83 TRR
T
•
0
1000.0000
1755
59670
SUK & IU PHREYS 673, 1985
84 77 5
T
•
0
5083000
1750
59665
HATCH & ANDERSON 629, 1985
85 GIN
0
-
-
1000.0000
1735
59650
CRESPI, RYAN, SEIXAS 497, 1985
86 SHL
S
-
-
1000.0000
1728
59643
OBE, HILLE, JONAS 439, 1985
87 CML
C
-
0
160.0000
4314
9992
TSUCHIYA & HATTORI 114, 1976
88 CML
C
•
0
75.4000
4359
20167
TURNER, PETRICCIANI, CROUCH 560, 1974
89 IFA
F
-
-
2000.0000
4386
58886
DIVINCENZO, HAMILTON, MUELLER 247, 1985
90 (Wi
0
-
0
5000.0000
10040
52793
KORNBRUST, BARFKNECHT, INGRAM 99, 1984
91 (Wi
0
-
0
500.0000
4387
56992
BUTTERWORTN, BER* EZ, SMITH-OLIVER 1329,
1984
92 MVN
N
-
0
6000.0000
4357
65187
DOUGLAS, HUGENHOLTZ & BLAXEY 255, 1986
93 CIA
C
-
0
49000000
4341
50726
PUTNAM, MOORE, SCHECHTNAN 227, 1983
94 DIM
C
•
0
13000.0000
4333
17788
SINGH, LAURENCE & AUTIAN 35, 1973
95 DIM
C
•
0
980.0000
4355
60736
AGARUAL. LAURENCE & AUTIAN 71, 1985
96 ICR
-
0
0.1000
10040
52793
KORNBRUST, BARFKNECNT, INGRAM 99, 1984
(NO)
97 SPN
-
0
6000.0000
4357
65187
DOUGLAS, KUGENHOLTZ & BLAKEY 255, 1986
(NO)
98 SPR
-
0
5200.0000
4357
65187
DOUGLAS, HUGENHOLTZ & BIAKEY 255, 1986
(HO)
99 ICR
•
0
5.0000
1745
59661
ELMORE, KORYTYNSKI & SMITH 597, 1985
(NO)
100 IWO
-
0
558.0000
4388
55892
DANIKEN, LUTZ, JACKH 373, 1984
(NO)
-------
DIETHYLNEXTLPHTHALATE 9-JUL-87 PAGE 41
117-81-7
HR. TEST END RESULT RESULT DOSE REF EMIC SHORT CITATION PLOT
CODE POINT NO ACT ACT (HID/LED) NUMBER NUMBER
DESCRIPTION TESTCCOES IN PNTLOGENETIC ORDER
Pro&aryotic syst
SAD a S.L.oneUa tlçhimoriue TA100, reverse .Jtation
SQ • SaLmonella typhi arius TAIO2 , reverse . tatlon
5*5 a Salmonella t flimorius TA1535, reverie ..itation
SAT s Sst.onetta typh iue TA1537, reverse Bitation
a Sal.onella typhiwjriia TA1538, reverse .jtation
5*9 a S.Lmon,L La typhi irius TA9 . reverse motat ion
s 5 a SalmoneLla typhi. riia (ether misc. straine), reverse ajt.tion
ECLI a Escherlchi. coIl LP2 uvrA, reverse .itatlcn
Lower ei aryotic syste
SCG a Saccharomyces cerevisias, gene conversion
SC M • S. cerevisl.s, h zygosis reco in.t1on or gen. conversion
MG • Asp.rgl (tue nl&lans, genetic crossing-over
SCF Sacch.rcc ces c.rsviaias, fonisrd jt.tion
SCM a Sacchsrc.yces cerevislas, reverse jtat Ion
SZF a Schi zossccharc.yces po e, forw.rd motat Ion
Insect syst
DI I I a Drosophi a melanogaster, seastic notation (end reco In.tIon)
DI a DroscphiL. mel..gaster, sex-lft*ed recessive l etha l jtstlcn
Animel c cl Is In vitro
DIA a DNA strand breaks, crout. or ret. d ge , ani..l set Is in vitro
UMP a thisct e Jled D NA s iithsls, rat prieary h.pstocyt.s
GST a Gene .jtation, mouse L5178Y c.Lts In vitro, TK locus
GS1 a Gene notation, mouse L5178Y cells in vitro, ill, other (oci
GIA a Gene notation, other enimet cells in vitro
SIC a Sister chromutid exchange. Chinese hter cells in vitro
SIA a Sister chro.ut ld exchang, ether anim.t cells In vitro
a IIicrc vjcleuc test, aniest cells In vitro
a Chrnmoecme( aberrations, Chinese htsr cells in vitro
CI a Chr ’— s’veL aberrations, other anleal cells In vitro
AlA a An. loidy, unimet cell. In vitro
TIM a C•lI tr formst ion, BALI/C3T3 mouse cells
TCM a Cell tronsforeatlon, C3N1OT1/2 . *e cells
TCS a CeLL tr formut1cn, Syrian h ter ryo cells, dod assay
TiM a cIt transformetlon. RLV/FISCIIER rat ryo cells
Tfl a c,tI trw formetf on, SA7/Syrlan htir eabryo ceLls
Ni.n cells in vitro
GIN a Gene notation, husan ceLls in vitro
a Sister chr tId exchange, h*mun l ocytes in vitro
-------
DIETHYLHEXYLPHTHALATE 9-JUL-87 PAGE 42
117-81-7
C I II * Chromosamal aberrations, hunan L mçhocytes in vitro
Body fluid and host mediated assays
BFA — Body fluids from animals, microbial ,mjtagenicity
Animal in vivo
UPQ a Unscheduled DNA synthesis, rat hepatocytes in vivo
M%t14 I4icronucteus test, mice in vivo
CU Chromosol aberrations, animal bone marrow cells in vivo
DIM Dominant Lethal test, mice
Alternative testcodes (not incl led In profiles)
I R a Ir iibition of intercellular co .r ication, rodent in vitro
SPII a Sperm morphology, mouse
W I a Sperm morphology, rat
IC R a Ir iibition of intercellular c x ication, rodent in vitro
BVD a Binding (covalent) to DNA, animal cells In vivo
ENDPOINT INDICATIONS
0 a DNA damage R a Recoeblnatlon G a Gene atstion S — SCE N a Micronucleus
C a Chro.osom. aberration A a Anet toidy T a Cell transformatlonF a Body fluids N a Ilostmediated assay
-------
DO NOT CITE C Q c.
No data were available ai the gaietic and related effects of
heptadtlor in humans.
Heptachior did r t induce &lni nant lethal; i ä i s in mice. It
induced unscheduled synthesis in human fibtoblast 1ltures xit r t
repair synthesis in cultured nt ni lian. cells. eptathlor thibited
intercellular c ium ication in rodent ce tL systen . It was r t
iaatagenic to cultured rat liver cells. t induce recessive
lethal tsitatia s in Droscçbfla gene vers i in yeast tt was
imitagenic to plants. tt was t tai ic to bacteria, it in one
study, csitive resu],t .yiere re * t f th ical-grade b.it r t
cci rcial-grade heptathlor . tt Cf id not proc uce breaka of plasmi.d
1 IA ; q r I2s, 5, L’Th: 20, l29 Supp l. 4 , 80
-------
- - ———
.:;:r— ——— - — ————— —— --
n-nianuna1ian øyat us
-
Prnjc.a- £ukar vtea
ryote --
-— — — —. —. • — — — — — —
H Uw syat Js
- -- - - - - . - - -. -
Iflyttro In vivo
.:::::::
- -
— — —. — —
.i4’ ,i .,, -— — — — — . — —
— —
DOD
;
AID
0
C
A
D
0
C
A
D
S
N
C
“.
A
-I
.—
t
- ...
N
C
AT D
0
S
H
C
A
IL
D
6
S
14
CA
T T
— — —
.
1
+
J
-.
•,
-
.
.
.
i
•.
•
.•
—
No. _____
Subgroup - — -
WA damage; (3, gene ,a.itatlon; C. thraioscnal aberrattona , sis A ane ploidy ‘F, cell
transformation, IL, daninant lethal, H, micronuclei, R, mitotic r )iflatlr3n or gene a*iversion I,. inktbiticn of intercellular
zxw’ ” dcaticr : .: :
-------
HEPTRCHLOR g-JUL-67
76-44-8
I lics I II
S. —
4. —
Ill
2-
: 3
w
In
—4- —
E W b 0
C III a i
S s1Is x a
I I FM I I I I H J
-------
4.
U’
2-
Ui
In
0
o 0.
uJ
0
-j
—2-
S S
I I
S I
9—JUL—87
HEPT CHLOR
76-44-8
8- —
6- —
I I I I I I II I I
I
N
I
.i
—4. —
I I I
E S S W G S
C I I L
I 51 5 5 x N I
PR ( VOT LO e wov PLR1T W CTh IWU .$ m VITRO I-U FM I * .I fl VI
m V Imo flVI
-------
HEPTACH LOP
7644-8
9-JUL-87 PAGE 43
Ni. TEST END
CODE POINT
RESULT RESULT
NO ACT ACT
DOSE REF EPIC
(HID/LED) NlJ 8ER flJ48ER
SNORT CITATION
PLOT
DEScRIPTION TESTCODES IN PHYLOGENETIC ONDER
Pro aryotlc syst
ECI a N. colt or CE. coIl DNA), strend breaks, crosstfs*s or repair
SAD • S.taon.lla t phi.jrls.. TA100, reverse ..,t.tfon
SAS * $a(a ta t .jriia 1*1535, reverse ..station
SAT a Set.onet La typM.jri*m 7*1537, reverse .itst Ion
a Sal.onsl La t Iasi a 7*1538, reverse tatlon
5*9 a SitmansIla typhl.urfia TA98, reverse itatiin
a Sat.onstta typhl.jrua (other alec. strains), reverse itation
Lower eL*aryotlc syst
SCG • Saccharoyces cerevisla. , gene conversion
Plant syst
PEP a Plants (other), utatfon
Insect syst
0101 a DrosoØ%its Lno,astei , su-Lti*ed recessive LethaL .atat lcn
Ani..L cells in vItro
a tksche .ited DNA synthesis, rat prfeary h.pstocytes
UIA a th clie Lsd DNA synthesis, other on1L ceLls In vitro
IA • Gins sititlon. other anleat cells in vitro
N.t cells In vitro
UNT a Ik die jLad DNA aynth.sIs. tr.nsfore.d bs. cell. in vitro
1 NCR
0
-
0
100.0000
2188
30811
GRIFFIN AND HILL 161, 1978
2 SAD
C
-
(+)
5.0000
1177
45215
GENTILE, GENTILE, RULTMAN 19, 1982
3 5*5
C
-
-
500.0000
2380
22818
MARSHALL, DOROUGH & SWIM 560. 1976
4 SAT
C
-
-
500.0000
2380
22818
MARSHALL, DOROUGH & SlUM 560, 1976
5 5*8
C
-
-
500.0000
2380
22518
MARSHALL, DOROUGH & SWIM 560, 1976
6 SA9
C
-
C)
5.0000
*177
45215
GENTILE, GENTILE, RULTMAJI 19, 1982
7 SAS
o
-
•
500.0000
2380
22818
MARSHALL, DOROUGH & SWIM 560, 1976
8 5CC
1
-
•
0.0000
1177
45215
GENTILE, GENTILE, BULTMAN 19, 1982
9 P 1.11
C
•
0
0.0000
1177
45215
GENTILE. GENTILE, ULTMAM 19, 1982
10 DM11
C
-
0
5.0000
2130
6618
BElIES & SEAM 50, 1969
*1 UNP
0
-
0
3.7000
740
37980
PROBST, MOIAHON, HILL 11, 1981
ia taP
o
-
0
3.7300
2246
41629
MSLAIISEY & WILLIAMS 121, 1981
13 UIA
0
0
4.0000
2246
61629
ISASLMISKY & WILLIAMS 121, 1981
14 CIA
C
-
0
37.0000
2294
47748
TELANG, TONG, WILLIAMS 1175, 1982
15 liii
0
-
•
37.0000
10079
24451
AISED, HART & LEWIS 161, 1977
16 DLII
C
0
24.0000
414
12984
EPSTEIN, ARNOLD, ANDREA 288, 1972
17 ICR
•
0
0.O 0O
2294
47748
TELAMG, TONG, WILLIAMS 1175, 1982
(NO)
18 ICR
(•)
0
10.0000
3694
66306
KURATA, NIROSO & IJIEDA 217, 1982
(N0
Aniast in vivo
-------
DIM D inant Lethat tests mice
ALternative teatcodes (not incLuded in profiLes)
ICR Inhibition of interceLLuLar coniiaJnication rodent in vitro
ICR Inhibition of interceLLular coavisI%ication rodent in vitro
ENDPOINT INDICATIONS
D s DNA damage I • RecouiCination G Gene ..Itation S • SCE N • MicronucLeus
C • Chromosome aberration A • Anet Loidy I • CeLL trarisformationF • Body fluids I I a Nostmediated assay
-------
LEAD AND LEAD
Studies of dr znos al aberrations in pe le exposed to lead have
c’c3
V been reviewed (1AW2, 1980b; Leonard, 1986). They have given conflicting
results: positive repo ts have been pablished a icerninq rkers in
lead—battery industries and lead snelters, bit othar studies of rkers
under . arable iditions have given negative results • Increased
incidences of sister diraatid exd anges have been reported in the
peri era1 bicod lynçhocytes of rkers exposed to lead bit nc’t in those
of thildren exposed to hi levels of lead in the environuent. An
ii eased incidence of sperm ax ].ities s seen in nen exposed
occupationally to lead.
Althci4 a few studies in rodentrs treated with lead salts in vivo
have n snell (bit 8ignificant) ir eases in the frequency of
d raicsaia1. aberrations and micrcnuclei in bone- iexT’c ,l cells, nost
studies ed r ir ease. lead salts caused uor * logical sperm
abirnalities in mice bit nct in rabbits (Willeee at al. , 1982). Sister
d r tid exthanges and unstheduled synthesis re r t induced in
cells of anii els treated with lead salts in vivo . Lead salts did nct
induce d . ecii l aberrations in hi man lyn 1x cytes in vitro .
Ca flicting results have been tained in assays for uC rp logica1
transfornetiai in cultured uu uu 1ian cells. Lead salts did nct cause
aneuploidy in mitation or gene version in yeast or
n*itation or k danage in bacteria.
Tetxaethyl— and tetranethyllead did rct induce nutatiai in
-------
bacteria, bit they caused specific inhibition of the spindle fibre
n d anism, and aneuploidy has been observed in plants and Dros ,hila.
Wxcgraphs , 1, 40; 2, 52, 150; 23, 325; Su l. 4 , 149
-------
— 4a-d Pb. _____
Subjroup -
- - ea—ae-p--
Pbn-niain Uan .y.t.i
- afle—-- -- ee.ea—---- -—————--—
t4aIuML tan ayet81
Proka- Eukaryotas
-- -- --- --
Vt t 5
vitro
—-- -- -—- - -- -
flyiyq
--•- . -.
I
----
DOD
;
A
j
D
0
C
A
D
0
C
A
D
S
M
C
A
T
I
0
(3
S
H
C
AT
]
D
0
S
H
C
A
IL
0
0
S
M
CA
—
.
— a
—
a
—
—
—
—
—
—,
e_
—
.j
—
—
.e
..e
4,
.
a
.a
i
.
.
.
—
—
0
•
1
•
9
•
•
q
•
?
•
0•0
— —
7
— —
•a
— d
•
S
—
—.
—.
S
—
D. WA damage; 0, gene nutation; C, diraiiecznal aberrations; 5, sister chranatid exchanges; A aneuploidy, T. cell
transformation. IL, daninant lethab H, micronuclet; R, mitotic recui ination or gene cxmversion; I, Thkthition of intercellular
ccimunlcaticii
-------
LE 1D g-JUL-B7
7439-g2-1
I I II I I
6-—
In
E2
3
Iii --1
In
I FM C I I ‘ I I R J I
-------
I I I I I I II I I
LE 1D
743g-92- 1
9-JUL-87
c i I It
II IPL
II S Rn
Sc
L L
H H
In
I-
C
3
U i
In
0
1!J
0
-J
6 —
4-
2-
0-
-2-
—4-
I S E S I I U C NW IC C
R I C ccc I N H H I (V VI I
I O57 U I N 0 N F I I U I II H
PR ( VOT LON £U( OT j PLmTS W &CTS FM l .5 ri vp. I&UYV
m
-------
LEAD
7439-92-1
9-JUL-87 PAGE 44
HR. TEST END
C E POINT
RESULT RESULT DOSE REF EMIC
NO ACT ACT (HID/LED) NUMBER NUMBER
SNORT CITATION
PLOT
1 850
0
0
100000.0000
73
20155
NISHIORA 185, 1975
2 SAO
C
-
-
250.0000
84
31926
BRUCE & HEDDLE 319, 1979
3 uO
G
-
-
166.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1, 1984
6 US
c
-
-
166.0000
1763
58507
DUNKEL, ZEIGER, BRUSICX 1, 1986
5 SA7
C
-
-
250.0000
84
31926
BRUCE & HEDOLE 319, 1979
6 SAT
C
-
-
166.0000
1763
58507
DUNKEL, ZEIGER, BRUSICX 1, 1984
7 548
C
-
-
166.0000
1763
58507
DUNKEL, ZEIGER, BRUSICE 1, 1984
8 SA9
C
-
-
250.0000
84
31926
BRUCE & HEDDLE 319, 1979
9 SA9
C
-
•
166.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1, 1984
10 ECU
C
-
-
166.0000
1763
58507
DUNKEL, ZEIGER, ORUSICK 1, 1984
11 SCO
P
0
62.0000
1074
49902
FUKUIIAGA, ICURAC III • MIZUQJCHI 3017, 1982
12 SCG
P
-
0
60.0000
2623
58864
KMARAB & SINCH 117, 1985
13 SC M
P
-
•
50000.0000
112
31454
SIPhON 901, 1979
16 5CR
C
-
0
207.0000
1074
49902
FUKUNAGA, KURACHI • MIZUQJCNI 3017, 1982
15 SCR
C
-
0
60.0000
2623
58864
KIIARAB & SINGH 117, 1985
16 0MB
A
-
0
200.0000
2001
36221
PANEl. & MAG*JSSON 59, 1979
17 CIA
C
(.)
0
207.0000
3520
11931
BAUCHINGER & SCNMID 95, 1972
18 IMII
T
•
0
0.5000
480
1024
JIKEL, PIENTA, SIVAX 1303, 1981
19 TRR
T
-
0
127.0000
480
1024
OUNICEL, PIENTA, SIVAK 1303, 1981
20 ICE
I
-
0
1.0000
473
15029
PIENTA, P01111 & LEBNERZ 662, 1977
(NO)
21 175
1
+
0
10.0000
9
31323
CASTO, MEYERS & DIPACLO 193, 1979
22 UMF
0
-
0
325.0000
633
31934
MITCHELL (1976 UNPUB.)
23 CIII.
C
-
0
207.0000
3523
13605
SCNMID, BAUCHINGER, PIETRUCE 401, 1972
24 CMI.
C
-
0
207.0000
2012
41604
GASIOREK & BAUCMINGER 513, 1981
25 CIII.
C
-
0
207.0000
1987
29104
DEK* T & DEMIMATTI 67, 1918
26 11*
N
-
0
3500.0000
185
31455
BIllION, ROSENICRAMZ, ZEIGER 911, 1979
27 INN
0
-
0
40.0000
2194
30122
CIIOIE & RICMTE* 235, 1978
28 uvi
D
-
0
10.0000
2241
41938
SARA!, *JRATA, CHIVA 1261, 1981
29 SvA
S
-
0
0.5000
2319
48035
WILLEMS, SCHEPPER, UIBOJO 149, 1982
(NO)
30 NWP
N
-
0
1000.0000
86
31926
BRUCE & NEDOLE 319, 1919
31 NNN
N
-
0
25.0000
1419
24472
JACa T , LEONARD & GERBER 619, 1917
32 IIVI
N
(.)
0
51.8000
3652
62147
TACHI, NISNIMAE & SAITO 144, 1985
33 NVA
N
-
0
0.5000
2319
48035
WILLENS, SCHEPPER, WIBOUO 149, 1982
(NO)
36 CM
C
-
0
1200.0000
1479
24472
JACOIJET, LEONARD & GERBER 619, 1917
35 CM
C
-
0
600.0000
1999
34009
DEKM T & GERBER 163, 1979
36 CM
C
(+)
0
10.4000
3652
62147
TACHI, NISNIMAE & SAITO 144, 1985
37 CLA
C
(.)
0
760.0000
3518
5918
PIJRO & GOYER 660, 1969
38 CLA
C
C.)
0
2.1000
3522
41103
JACCUET & TACHON 165, 1981
39 SLN
S
•
0
0.6000
3653
53770
GRAJIDJEAM, WLF & NIEBUMP 199, 1983
40 SI.N
S
-
0
0.6000
3651
50709
DALP*A, TIBILETTI, NOCERA 249, 1983
(NO)
41 SLN
S
(‘)
0
0.4900
3657
67542
MAICI-PAAEXAIIEM, SORSA & VAINIO 269, 1981
42 CLII
C
-
0
0.0000
3523
13605
SCIIIID, BAUCMIMGER, PIETRUCE 401, 1972
43 CUP
C
+
0
0.0500
3654
63551
AL-KAKICAK, PIAIPAIIT, Il.*AO 53, 1986
44 CUP
C
-
0
0.4900
3657
61542
IIAEI-PAAICKAMEN, SORSA & VAINIO 269, 1981
(NO)
65 SPI
•
0
100.0000
86
31926
BRUCE & PIEDOLE 319, 1979
(NO)
46 5PM
•
0
760.0000
2151
41134
EYDEN, MAISIN & IPATTELIN 266, 1978
(NO)
-------
LEAD 9-JUL-87 PAGE 45
7439-92-1
DESCRIPTION TESTCODES IN PHYLOGENETIC ORDER
Prokaryot ic systems
BSO Bacillus su. tilis rec strains, differential toxicity
5*0 — SaLmonella typhijri .a TA100, reverse eutation
5*5 • Satmanel. La typhins.lri.a 1*1535, reverse m.itation
sAT a Salmonella typhieuri 1*1537, reverse mJtat on
5*8 a Salmonella tyhieuriuu TA1538, reverse ,usjtation
5*9 SalmoneL La typhi rius TA98 , reverse lutation
EC J — Escherichia coti 12 uvrA, reverse n tatian
Lower eukaryotic systems
SCO a Saccharomyces cerevisiae, gene conversion
SCH — S cerevisiae, homozygosis by recon ination or gene conversion
SCR • Saccharomyces cerevisiae, reverse usJtation
Insect systems
DMN a DrosoØ ila melanogaster, anetçloidy
Animal celLs In vitro
CIA • Chromoscast aberrations, other anit cells in vitro
IBM a c•(l transformst Ion, 8ALB/C3T3 mouse eel Is
ICS • Cell transformation, Syrian h ter enteyo cells, clonal assay
TRR • CelL transformation, RLV/FISCHER rat eobcyo cells
175 a Cell transformation, SAT/Syrian hter estryo cells
Nusun ceUs In vitro
UHF a Unsche 1jled DNA synthesis, hti flbrcblasts In vitro
CI II • Chrcmasol aberrations, h*.man Lyuçhocytes in vitro
Body’ fluid and host mediated assays
Host mediated assay, microbial cells In animal hosts
Animal in vivo
UVM • Unsche led DMA synthesis, mouse cells in vivo
UVR • UnscheQaled DNA synthesis, other rat cells in viva
SVA • Sister chros.tid exchange, anImal cells in vivo
M W a Micronucleus test, mice In viva
MVR • Micronucleus test, rats In viva
PIVA • Micronucleus test, other animals in viva
CU * Chromosomsl aberrations, animal bone morrow cells in vivo
a Chromosomel aberrations, animal leukocytes in viva
Pkaan in viva
SIN • Sister chromatid exchange, husan lys hocytes In viva
CIII a Chromosomot aberrations, hunan l sçhocytes In viva
Alternative testcodes (not included in profiles)
-------
SPN s Sperm rphoLoqy. mouse
5PM a Sperm morphoLogy, mous.
ENDPOINT INDICATIONS
D • DMA damage = Rec ination G a Gene .ltation S a SCE 14 a MicronucLeus
C a C4 rnmoscme aberration A a Anei toidy I a C (L transformetionF a Body fLuids 14 a Nostmediated assay
-------
NICKEL P ND cX!IPcXJND&
The genetic toxicology of nickel has been reviewed (Venitt, 1986).
‘t brkers exposed to nickel in refinery had slight excesses of
dtratcsaial aberratia s (n inly gaps) in their peri era1 lynpl ytes,
bit rc increase in sister chraTatid exchanges was seen (see Leonard,
1966; Venitt, 1986).
Nickel crz p inds did rct induce d ninant lethal nutations in mice.
Soluble nickel catp u s caused 1 strar I eaks and cross—links in -
rats treated in vivo and particles of crystalline nickel suiphide .ind
to 1 in Q inese haiTater cells in vitro . Nickel ir 3s were weakly
active in inducing thrat saTa1 aberrations and sister d raTatid
exchanges in urinu lian cells in vitro . They induced norplclogical
trarisfornation in several test syst Ta using u 1ian cells in vitro .
In general, negative results have been cbtained in bacterial nutation
assays; nickel catçx mds induced ,irv I age in bacteria. Insoluble nickel
xrpx nds baind to isolated Particles of crystalline nickel
suiphides induced i utation in a protozosn.
? kzographs , 2, 126; 11, 75; Sopol. 4 , 167
-------
i 1 1) ckaL b. -
Subjrc ip ______
— —p —-— ——
Non-ni m lian syst
— —
Pr ka- ikaryotes
ryotea
— -I— -—-
Plants Insects
eukaxyotes
— -— — —— — — —
- —ee—--— —p —e—
Manrialian syst ns
— e•— — ee S — — — — —
In vitro j vi q
—
-
— - ---——a -—
Non-htman
•
— .ea —. —. — — S
! -- -
I*zi n S Non-htinan
.
— — — — — — a — — ea . — —
——
Hui n
— — — — —
— —
DGD
—
;
a
Al
D
U
c
A
D
U
C
A
D;
S
H
C
A
T
I
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AT
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H
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A
DL.
D
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:
=
:
:
:
:
:
:
:
:
:
:
:
::
:
:
:
:
:
:
:
:
:
D. ttIA danrge; U. gene imitation; C, thraiceam l aberrations; S. sister chranatid excharw.jea; A, aneuploidy, T, cell
transformation. IL. daninant lethal; M, micronuclei; R, mitotic re thination or gene cxmversion; I, inhibition of intercellular
aimun caUm
-------
flICKEL 9-JUL-B?
7440-02-0
I I I I t I ss I I
6- -
4.
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—4- —
0 U H S%SE 0
I V I A II( II t
H I I 0992 NI I
I ° 1 I I I ‘ I
-------
flICKEL
7440-02-0
P
H
I
9-JUL-B?
I I I i i I
S
C
I I
S SE H II U H
ii I i v
O I2 Hi H II I I
PRCKmvOT LOS EU( QT PI T5 NSCTS W TRO I4U FlU I $ I V!JO ILU
m nmo
6 —
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4
2
0.
-2
—4. —
-------
NI CKEL
7440-02-0
9-JUL-ST PAGE 46
WR. TEST EI
C E POINT
RESULT RESULT
NO ACT ACT
DOSE REF ERIC
(HID/LED) NLJIBER NLJI8ER
SHORT CITATION
1 PU
D
•
0
9.4000
1766
52886
ROSSI4AN, MO(.IMA & MEYER 59, 1984
2 SAO
C
-
-
333.0000
638
52195
HAWORTH, LAWLOR, MORTELMANS 3, 1983
3 5*0
C
-
0
587.0000
812
41538
TSO & FUNG 195, 1981
4 SAS
C
-
-
333.0000
638
52195
HAL RTM, LAWLOR, MORTELMANS 3, 1983
S 5A7
C
-
-
333.0000
638
52195
HAWORTH, LAWLOR, MORTELMANS 3, 1983
6 5*9
C
.
-
-
333.0000
638
52195
NAWORTN, LAWLOR, MORTELMAMS 3, 1983
7 EC2
C
-
0
4.5000
677
21923
GREEN, MURIEL & BRIDGES 33, 1976
8 5CC
R
•
0
176.0000
1074
49902
FUKIJIAGA, KZJRACNI, MIZUGUCHI 3017, 1982
9 P 511
G
•
0
0.0000
3660
56073
SMITN-SONMEBORN, PALIZ2I, MCCANN 205, 1983
10 PSC
C
•
0
0.5000
3660
56073
SMITH-SONNEBORN, PALIZZI, MCCANN 205, 1983
11 01*
0
C ,)
0
176.0000
532
50861
5111*, BEAR, DYSART 357, 1983
12 DIA
0
•
0
10.0000
3547
46290
COSTA, HECK & ROBISON 2757, 1982
13 01*
0
+
0
1.0000
3548
65054
ROBISOII & COSTA 35, 1982
14 RIA
0
•
0
0.6000
1229
48673
ROBISON, CANTONI, HECK 273, 1983
15 G9W
C
-
0
23.0000
2000
34022
MIYAICI, AKAMATSU, 0110 259, 1979
16 GST
C
•
0
17.6000
809
37075
AMACHER & PAILLET 279, 1980
17 CIA
C
-
0
5.0000
842
37308
RIVEDAI. & SANNER 203, 1980
18 SIC
S
•
0
0.2500
1024
65501
DENG S CU 212, 1961
19 SIC
S
C.)
0
1.1200
1003
41825
LARRAMENDY, POPESCU, DIPACLO 597, 1961
20 51*
S
C.)
0
32.0000
939
45292
011110, NANAOKA, YAMADA 161, 1962
21 CIC
C
•
0
0.6000
3549
59105
SEN S COSTA 2320, 1985
22 CIS
C
C ’)
0
1.1200
1003
41825
LARRAMEIOY, PCPESOJ, DIPAOLO 591, 1981
23 CIT
C
C’
0
58.7000
175
31682
IJRIDA S NISIIIIBJRA 221. 1979
24 T
I
•
0
0.0000
3661
43496
SAXNOUI, R!ITN S BROGGER 4136, 1981
25 TCS
I
•
0
1.0000
15
502
DIPAOLO S CASIO 1008, 1979
26 TCS
I
•
0
0.2000
346
976
COSTA 373, 1960
27 ICC
I
•
0
20.0000
842
37308
RIVEDAL S SANNER 203, 1980
28 TCS
I
(•)
0
0.0000
923
648
NECK S COSTA 19, 1982
29 ICC
T
•
0
10.0000
3547
46290
COSTA, HECK S ROSISON 2757, 1962
30 TCS
I
C ’)
0
5.0000
1448
1220
RIVEDAL S SANNER 251, 1963
31 TCS
T
c•)
0
40.0000
473
15029
P1811*, POILEY I LEBIIERZ 662, 1977
32 TFS
T
•
0
2.0000
346
976
COSTA 373,. 1980
33 TRY
T
•
0
10.0000
889
7
WILSON S KNOOBYARIAR 253, 1982
34 175
I
•
0
22.3000
9
31323
CASIO, MEYERS S DIPACLO 193, 1979
35 ITS
T
•
0
100.0000
488
33543
CASIO, MIYAGI, MEYER 255, 1979
36 DIN
0
-
0
3.0000
1076
45434
MCLEAN, WILLIAMS, KAPLAN 137, 1982
31 DIN
D
•
0
56.0000
991
43342
FURNACE 145, 1962
38 SRI.
S
C.)
0
7.0000
905
45220
NEIIIAN, SII ITT, NUNEZ 67, 1962
39 SRI.
S
C.)
0
3.6000
1004
36303
JJLF 40, 1980
40 SRI.
S
(+)
0
1.1200
1003
41825
LARRAMENOY, POPE SCU, DIPAOLO 597, 1981
41 SRI.
S
•
0
0.2500
1026
65501
DENG S CU 212, 1961
42 SRI.
S
C-)
0
0.0000
3661
43496
SAXNOLM, REITH S BROGGER 4136, 1961
43 C XI.
C
C•)
0
1.1200
1003
41825
LARRAMENOY, POPESCU, DIPAOL0 597, 1961
44 INS!
N
-
0
50.0000
673
14101
BUSELMAIER, RONRBGRN I PROPPING 311, 1972
45 DVA
0
•
0
10.0000
3546
46763
CICCARELLI & TTERMAHN 3544, 1982
46 OVA
0
•
0
20.0000
3545
41028
CICCARELLI, HAMPTON I JENNETTE 349, 1981
67 INN
0
-
0
10.0000
2261
41938
SAUl, PRJRATA, CHIVA 1261, 1981
48 DLII
C
.
0
56.0000
1234
48803
DEK* T I LEONARD 269, 1962
49 SIN
S
-
0
0.1400
3550
57113
WAKSVIK, BOYSEN S NOGETWIT 1525, 1984
(110)
SO 51.11
S
-
0
0.0700
906
45078
WAKSVIK S BOYSEN 165, 1982
(NO)
-------
9-JUL-87 PAGE 47
NICKEL
7440-02-0
HR. TEST END RESULT RESULT DOSE REF EMIC SHORT CITATION PLOT
C00E POINT NO ACT ACT (HID/LED) NUMBER NUMBER
51 CLI I C (.1 0 0.1400 3550 57113 UAKSVIK, BOYSEN & HOGETVEIT 1525, 1986
52 CLII C ( ) 0 0.0300 906 45078 WAKSVIK & BOYSEM 185, 1982
53 BID • 0 176.0000 3649 67550 LEE, CICCARELLI & JENNETTE 771, 1982 (NO)
54 BID (+) 0 10.0000 3650 4.6558 HARNEIT, ROBINSON, SCHIJARTENDRUBBER 20, 1982 (NO)
55 BIP (+) 0 10.0000 3650 4.6558 HARNETT, ROBINSON, SCHWARTENDRUBBER 20, 1982 (NO)
DESCRIPTION TESTCODES IN PHYLOGENETIC ORDER
Prokaryot Ic systems
PRB Prophage. in .Iction , SOS repel r, DNA strand breaks or crosal inks
SAC Salmonella typ&iimurlus TAIOO , reverse mutation
SA5 a Salmonella typhimurfia TA1S3S, reverse mutation
5 *7 SaLmonella typhimurh TA1537, reverse mutation
5*9 SalmonelLa typhimurius TA98 , reverse mutation
EC2 a Escherichha coIl 2, reverse mutation
Lower eukaryotlc systems
SCG a S.ccharoyces cerevislae, gene conversion
PSN a Paramecius species, mutation
PSC a Parecita species, chromosomal aberrations
Animal cells in vitro
DIA • D MA strand breaks, crossl. or ret, damage, animal cells in vitro
RIA • DNA repair exclusive of LOS, animal cells in vitro
0911 a Gene mutation, Chinese h ter lia g V-79 cells In vitro, NPRT
GST • Gene mutation, mouse L517SY cells In vitro, TK locus
CIA a Gene mutation, other animal cells in vitro
SIC a Sister chr tid exchange, Chinese hamater cells in vitro
SIA * Sister chromatid exchange, other animal cells in vitro
CIC • Chrowoscmal aberrations, Chinese h t.r cells In vitro
CIS a Chromosomat aberrations, Syrian hter cells in vitro
CIT • Chromos L aberrations, transformed cells in vitro
TON a cell transformation, C3NIOT1 /2 mouse ccl La
TCS • Cell transformation, Syrian hter eabryo cells, clonal assay
TFS a Cell transformation, Syrian h ter eabryo cells, focus assay
T7S a Cell transformation, SAT/Syrian hter e ryo cells
1EV a Cell transformation, other viral eabancement systems
Htaan cells In vitro
DIN a DNA strand breaks, crossl. or ret, damage, hussn cells in vitro
SIlL a Sister chromstld exchange, husan lysphocytes in vitro
CML a Chromosomat aberrations, hiaen lysçhocytes in vitro
Body fluid and host mediated assays
Hill a Host mediated assay, microbial cells in animel hosts
Animal in vivo
DVA a DNA strand breaks, crosst. or ret, damage, ammats in vivo
-------
UVR Unsch. .iLed DNA synthesis, other rat ceLLs in vivo
DLN • Oc.ir ant Lethal test, mice
Ni i in vivo
SI.H • Sister chromitid exchange, hi.min Lyi hocytes in vivo
C l ii • Chro.oscmit aberrations, hij..n Ly hocytes in vivo
ALternative testcodes (not incLuded in profiLes)
BID • Binding (covalent) to DNA in vitro
BID Binding (covaLent) to DNA in vitro
BIP • Binding (covalent) to RNA or protein in vitro
EI POINT INDICATIONS
D a DIIA damage R • Rccabination G • Gene . tatian S • SCE N • MicronucLeus
C a Chromosome aberration A • An.*çtoidy T • CeLL transfortionF a Body fLuids N a Noetmediated assay
-------
N-NITROSODIPHENYLAMINE
In a single in vivo test, N—nitrosodiphenylam.tne did not induce
sister chromatid exchanges in Chinese hamster bone marrow cells.
Treatment of rat primary hepatocytes in vitro did not induce unscheduled
DNA synthesis but did induce DNA strand breaks. Negative results were
reported f or gene mutation in m imnalian cells except in one conflicting
report with mouse L5178Y cells. Conflicting results were obtained for
sister chronatid exchanges in CHO cells. Chromosomal aberrations were
not induced in ni mm lian cells in vitro by N—nitrosodiphenylam.tne.
Transformation did not occur in Balb/C3T3 cells but conflicting results
were reported for RLV/Pisher rat embryo cells. N—nitrosodiphenylamine
did not cause prophage induction and induced bacterial mutation only
in two conflicting reports. Conflicting results were obtained for
differential toxicity in Escherichia coli . In single studies, differential
toxicity was observed in Bacillus subtillus and Saccharcmyces cerevisiae .
Neither recombination or gene conversion were induced in Saccharomyces
cerevisiae . N—n.ttrosodiphenylamine induced reverse mutation and aneuploidy
in Saccharoinyces cerevisiae in single studies but did not induce mutation
in Schizogacchrcmyces pombe and Neuroepora crassa . In a single study
in Vicia faba , it did not induce chromosomal aberrations.
N—nitroeodiphenylamine was not inutagenic to bacteria in a host-mediated
assay in mice.
-------
Compound N-ni trosodiphylamine
lon—maumialtan Syatems
Ma.llan lyst.
Proka-
ryotee
lukaryotsi
In ttro
In
Lower
Plants
Insect.
D G
—
rukaryote.
DGCAR
+?
DGIC*
1
DGCA
l on-huaan
DGBMCATI
+—? —
Iuaa
DOINCATI
onhuasn
DGØMCADL
D [ GBMCA
D, DNA damagei 0. gene mutations C, chromosomal ab.rrations S. ai.t.r chromatid •xchang.u A.
anauploidy, T,.cell transformation, DL, dominant lethal, M. mioronucl.i R, mitotia
racombination or gene conversion; I, inhibition of intercellular counioation.
-------
fl-flhTRO5OD pHEflyLRrflIflE 9-JUL-B?
86-30-6
I II I I II I I
6- —
—2
—4 AM \
A
PE U N % EE 511 S S VU V
NC N I if lNlN 1(C Z( U I V II I
II P I 91 RI51 Ifl FA IOTI C I CCA I
fll . I I I ‘ I -- 0 01R J C L T FC TIOfl
-------
fl-flhTflOSODlPHEflvLclrflIflE
86-30-6
S S
C C
N fl
T
A
N
9—JUL—87
II I I
P S fl V U (C T H S
AC R CC it F N •%I II I I V
B I I IA l F N C P I 1I C CA I I B
C VOT LOIW tI( WOTE5 P!. T N CT P S ri TPO I4ZW M U S I
Ifl VIT VI
8- —
6- —
4.
2-
0-
-2
I.n
I—
C
w
In
0
0
0
-J
A
—4-
A
-------
N-NITROSODIPNENYLANINE
86-30-6
9-JUL-87 PAGE 48
NB. TEST END
COOE POINT
RESULT RESULT
NO ACT ACT
DOSE REF ENIC
(KID/LED) IBJ BER NLB4BER
SNORT CITATION
I PU
D
-
•
100.0000
4301
40949
DAJIBLY, T04AN & RADMAN 219, 1981
2 P BS
D
-
•
2000.0000
3336
60950
THONSON 224, 1981
3 PBS
0
-
-
2000.0000
10042
52547
MAMBER, BRYSON & KATZ 141, 1984
4 Ed.
0
-
-
2300.0000
1590
40948
ROSEHKRANZ, KYNAN & LEIFER 210,
1981
S Edt.
0
0
-
250.0000
184
31449
ROSENKRANZ & POIRIER 873, 1979
6 ERD
0
C .)
500.0000
2141
40965
GREEN 183, 1981
7 ERD
D
(+)
-
100.0000
1588
40947
TUEATS 199, 1981
8 ERD
0
0
-
2000.0000
1428
48782
MANNER, BRYSOW, KATZ 135, 1983
9 350
0
C.)
-
2.0000
3676
40944
KACA 175, 1981
10 SAF
6
0
-
500.0000
1596
40966
SKOPEK, ANOON, KADEN 371, 1981
11 SAC
6
-
-
1000.0000
2147
40954
BROOKS & DEAN 261 1981
12 SAC
C
-
-
2500000
2126
40957
MACDONALD 285, 1981
13 SAC
C
-
-
50.0000
1598
40959
WAGAO & TAJCAHASNI 302, 1981
14 s o
o
-
-
5000.0000
1597
40960
RICHOLD & JONES 314, 1981
15 saD
6
-
-
991.0000
4343
55491
ARAKI, NURAMATSU & MATSUSNIM 8,
1964
16 SAC
C
-
-
166.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1, 1984
17 SAC
C
-
•
125.0000
111
31452
SIPI ON 893, 1979
18 5*3
G
.
-
100.0000
2168
40953
BAKER & BONIN 249, 1981
19 SAS
C
•
-
1000.0000
2147
40954
BROOKS & DEAN 261, 1981
20 SA5
6
-
-
5000.0000
1597
40960
RICIIOLO & JONES 314, 1981
21 5*3
C
•
-
150.0000
1393
40967
GATEHDUSE 376, 1981
22 5*5
6
.
•
166.0000
1763
58507
DUNEEL, ZEIGER, BRUSICK 1, 1986
23 5*5
6
-
-
18.0000
184
31449
ROSENKRANZ I POIRIER 873, 1979
24 5*3
6
-
-
125 0000
111
31452
SINBON 893, 1979
25 SA7
C
-
-
1000.0000
2147
40954
BROOKS & DEAN 261, 1981
26 SA7
6
-
-
250.0000
2126
40957
MA ONALD 285, 1981
27 SAT
6
•
-
50.0000
15%
40959
MACAC & TAICANASIII 302, 1981
28 SAT
C
-
-
5000.0000
1597
40960
RICNOLD & JONES 314, 1981
29 SAT
6
-
-
150.0000
1393
60967
GATENDUSE 376, 1981
30 SAT
C
-
-
166.0000
1763
58507
0 JIICEL, ZEIGER, BRUSICK 1, 1954
31 SAT
C
-
-
13.0000
111
31452
SD OSI 893. 1979
32 5*8
6
-
•
1000.0000
2147
40954
BROOKS & DEAN 261, 1981
33 5*8
6
-
-
5000.0000
1597
40960
RICHOLO & JONES 314, 1981
34 SA8
C
-
-
166.0000
1763
58507
OUNKEL, ZEIGER, BRUSICK 1, 1984
35 5*8
6
-
-
13.0000
186
31449
ROSENKRAJIZ & POIRIER 873, 1979
36 5*8
C
-
-
13.0000
111
31452
SI IION 893, 1979
37 5*9
6
-
-
1000.0000
2147
40954
BROOKs & DEAN 261, 1951
38 SA9
6
-
-
30.0000
2126
40957
MACDONALD 285, 1981
39 SA9
C
-
-
50.0000
1598
40959
NAGAO 4 TAKAUSNI 302, 1951
40 5*9
6
•
-
5000.0000
1597
40960
RICHOLD & JONES 316, 1981
41 SA9
6
•
-
150.0000
1393
40967
GATENOJSE 376, 1981
42 5*9
6
-
-
166.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1, 1986
43 SA9
C
-
-
125.0000
111
31452
SINBON 893, 1979
44 5*5
6
-
-
1000.0000
2147
40954
BROOKS & DEAN 261, 1951
45 SAS
6
•
-
125.0000
111
31452
SINBON 893, 1979
46 EdI
6
-
•
1000.0000
1393
40967
GATENOUSE 376, 1981
47 EdtJ
6
-
-
991.0000
4343
55491
ARAXI, *JRAMATSU & MATSUSNIMA 8,
1984
48 EC i
C
-
•
166.0000
1763
58507
DUNKEL, ZEIGER, BRUSICIC 1, 1986
49 ECZ
6
-
C,)
8.0000
1602
40966
VENITT & CROFTON-SLEIGN 351, 1981
50 ECR
C
•
•
3300.0000
4335
17876
NAKAJIMA, TANAKA & TOJYO 361, 1974
-------
N- MITROSODIPHENYLAMINE
86-30-6
9-JUL-87 PAGE 49
MR. TEST END
CWE POINT
RESULT RESULT DOSE REF EMIC
HO ACT ACT (HID/LED) NUMBER NUMBER
SNORT CITATION
PLOT
DESCRIPTION TESTC00ES IN PHYLOGENETIC ORDER
Prokaryotfe syste
P U Propl age, inójction, SOS repir, DNA strand breaks or crosst inks
ECL a Escherichia coil poi A1W3I1O-P3478, diff. toxicity (tfq. susp. test)
ERD a Eacherichia coil rec strains, differential toxicity
850 a Bacillus gi. t1Lls rec strains, differential toxicity
SAF a Salmonella typhiiriia , forward atatf on
SAO • SaLmonel (a typhljri(a TA100, reverse jtat ion
SA5 • Salmonella typhiaa.arfta 1A1535 , reverse u.jtation
SAT • Salmonella typiiiasirius TA1S3T, reverse uzjtation
SAS a Salmonella typhhuairius TA1538, reverse ftltation
SA9 a SalmonelLa typhi rius TA98, reverse saitation
51 SSO
D
+
+
100.0000
1581
40976
SHARP & PARRY 502, 1981
52 SCO
R
-
-
333.0000
1422
40972
JAGANNATH, VULTAGGIO & BRUSICK 456, 1981
53 SCG
R
-
-
0.0000
1583
40974
ZIMMERHAWN & SCHEE1. 481, 1981
51. SCG
R
-
300.0000
1582
40975
SHARP & PARRY 491, 1981
55 SCM
R
-
-
10.0000
2135
40971
KASSINOVA. KOVALTSOVA, MARFIN 434, 1981
56 SCM
R
-
-
50000.0000
112
31454
SIMMON 901, 1979
57 Sal
0
(+)
-
889.0000
1579
40969
MEHTA & VON BORSTEL 414, 1981
58 SZF
G
-
-
5.0000
2134
40970
LOPRIENO 424, 1981
59 NCR
C
•
0
196.0000
4310
8333
MARQUARDT, SCHWAIER & ZIMNERMANN 135, 1962
60 Sal
A
•
300.0000
1599
40973
PARRY & SHARP 468, 1981
61 VFC
C
0
4000.0000
4309
8324
KIHLMAM 43, 1961
62 DIA
0
•
0
198.0000
4339
46192
BRADLEY, DYSART, FITZSINI#IOSIS 2592, 1982
63 DIA
0
•
0
595.0000
532
50841
SIMA, BEAN, DYSART 357, 1983
64 URP
D
0
0.0000
740
37980
PROBST, MCMAHOM, HILL 11, 1981
65 URP
0
-
0
198.0000
4380
31477
WILLIAMS & LASPIA 199, 1919
66 0911
0
-
99.0000
4362
24619
KUROKI, DREVON & MONTESANO 1044, 1977
67 0911
0
-
196.0000
4400
34477
JONES & HUBERMAM 406, 1980
68 090
0
•
-
198.0000
6400
34477
JONES & HUBERMAN 406, 1980
69 GST
C
-
-
110.0000
2138
40984
J0TZ & MITCHELL 580, 1961
70 GST
0
-
•
75.0000
1770
52282
OBERLY, BEi4EY, PROBSI 291, 1984
71 GST
C
0
(+)
1000000
146
31144
CLIVE, JOHNSON, SPECTOR 61, 1979
72 051
C
0
-
100.0000
146
31144
CLIVE, JOHNSON, SPECTOR 61, 1979
73 CIA
S
•
0
1.0000
4609
28445
MISHAR, WILSON, PANT 79, 1978
(NO)
74 SIC
S
-
•
200.0000
2143
40980
EVANS & MITCHELL 538, 1981
75 SIC
S
-
-
100.0000
1586
40982
PERRY & THOMSON 560, 1981
76 SIC
S
+
0
20.0000
490
25199
ABE & SASAXI 1635, 1977
77 CIC
C
-
0
99.0000
490
25199
ABE & SASAXI 1635, 1977
78 CIC
C
1
0
30.0000
1876
24895
ISHIDATE & 00ASHIMA 337, 1977
79 CIR
C
-
0
50.0000
2144
40983
DEAN 570, 1981
80 IBM
I
-
0
125.0000
4346
SIVAK, CHAREST, RL ENK0 133, 1980
81 TBM
T
-
0
50.0000
480
1026
DUNKEL, PIENTA, SIVAX 1303, 1981
82 TRR
T
•
0
1.5000
480
1024
DUNKEL, PIEPITA, SIVAK 1303, 1981
83 TRR
T
-
0
1.0000
4409
28445
M!SHAR, WILSON, PANT 19, 1978
(NO)
84 11MM
H
•
0
5000.0000
185
31455
S1$ION, ROSENKRANZ, UlCER 911, 1979
85 SVA
S
•
0
200.0000
1244
48665
NEAL & PROSST 33, 1983
86 SPN
•
0
1000.0000
597
37395
TOPHAII 379, 1980
(NO)
-------
N-NITROS ODIPHENYLAJ4 INE 9-JUL-87 PAGE 50
86-30-6
SAS a SalmoneLLa typhi.jri (other misc. strains), reverse a.Jtation
EC!II Escherichia cot i iP2 uvrA , reverse .atation
EC2 a Escherlchia call 2 , reverse atation
ECR a Escherichia cot i (other misc. strains), reverse jtation
Lower eukaryotic systees
a S. cerevisiae, DNA repair-deficient strains, differential toxicity
SCG a Saccharo.yces cerevisiae, gene conversion
$C$ * S. cerevisiae, hc.ozygosis by reccobinatlon or gene conversion
SC * Saccharc.yces cerevisi as, reverse sitat ion
SZF a Schizosaccharc.yces poabe, forward aitation
NCR • Neurospora crusa, reverse s tat ion
5CR • Saccharo ces cerevisiae, aietçloidy
Plant syst
VFC • Vicia fibs, chrosos t aberrations
Animel cells in vitro
DIA a D MA strand breaks, crosal. or ret. d ge , aMmst cells In vitro
a Lk sdi.ó.it.d DNA syothesis, rat primery h.patocytes
a Gene sitation, Chinese hamster t*a g V-79 cells In vitro, NPRT
G90 a Gene satstion, Chinese htsr tirig V-79 cells In vitro, ouabain
GST a Gene sitatfon, amuse LSI7SY cit Is In vitro, 1K Locus
GSl a Gins sitation, amuse LSI7BY cells In vitro, alt other loci
CIA • Gene ..atatlcn, other animel cells In vitro
SIC a Sister cfir tfd exChange, Chinese hter cells In vitro
dc a Chr u’—t tharratbxs, Chin.se hter eel Is in vitro
CI I a Chr ’ ’somst aberrations, rat cells In vitro
TIN s c•l transformetion, SALI/C3T3 mouse cells
TSR a c 5t transformation, ILV/PISCIIE* rst ryo cells
Body fluid d host mediated assays
II • Nost mediated assay, microbial ccl Is in animal hosts
Animal in vivo
SVA a Sister chrcmatid exchange, anImal cells In vivo
Alternative testcodss (not included In profiles)
5PM a Sperm morphology, amuse
EJCPOINT INDICATIONS
0 a D M A da s 5 a Reecobination C a Gene sitation S a N • Nicrore.jcleus
C a Chrosos aberration A • Ane .ploidy T a CeLl transformetionf a Body flulde H • Noetmediated assay
-------
DO NOT CITE OR QL’ TE
No data were available on the genetic and related effects of polychlorinated
biphenyls in humans.
Dominant lethal effects were not induced in rats by oral administration
of polychiorirtated biphenyls, but were produced in rats nursed by females
that received polychlorinated biphenyls orally. They did not induce chromosomal
aberrations in bone marrow cells or spermatagonia of rats treated in vivo .
Micronuclei were not induced in bone marrow cells of mice in one study in
vivo , while equivocal results were obtained in a second study in which the
polychiorinated biphenyls were administered in corn oil. They did not transform
Syrian hamster embryo cells in vitro . Polychiorinated biphenyls induced DNA
strand breaks and unscheduled DNA synthesis in rat hepatocytee in vitro .
Neither chromosomal breakage nor aneuploidy was induced in Drosophila .
Polychiorinated biphenyl mixtures did not induce SOS repairs and were not
mutagenic to bacteria.
2,2’,5,5’-Tetrachlorophenyl induced DNA strand breaks in mouse cells in
vitro . 2,4,5,2’,4’,5’-Hexachlorobiphenyls but not 3,4,5,3’,4’,5’—hexachloro—
( c((ecf)
biphenyls inhibited intricellular coimnunication in Chinese hamster V79 cells.
Purified 2,4,2’,4’—, 2,5,2’,5’— and 3,4,3’,4’—tetrachloro— and
2,4,6,2’,4’,6’—hexachlorObiphenYi. were not mutagenic to Salmonella typhimurium .
-------
r :i
Ii .
DO NOT CITE OR TE
Pk .
a-
——---a. ——
n- i Uan .y.tI
H MUan ayat
—- —— -—— ————---s———ap
—_p—_—— —p—__ -— ————e_ ———
—
PEd a- j ryrj
L er
Ca — — — • • • — — — — •• — — —
DOD ; AI DOCADOCA
Ifl vitro
1LYA
- - -
I1an4 n -
— —— — —, — —i S
DSMcATII
Non-lu n
— — — — — — se —, —, Cs —
DOSNC&T DGSNCA
— — — — —
DGSNC
—
A
a
5
Cs
S
e
a S e
5
a
as
•
5
SO
—
ea
S S
a Cs —
5
a I I
a
SC
SO
.k
S
+
5 S
5
5
S
5
Cs
-I
Cs
I
.
?.
?.
.u!ip.e
Cs
5
5
(1, qer *statlau C, thr l abrr tIcns; S. .tat.r dw tid .zthan es; A, eneiç loidy, T, cell
transtccmattai. IL, d ainint 1 b N, lcivmicl$j N, .itct.lc re th t1a or g ccn re1cnj I, iJthtbiticm of Intercellular
‘ i Icati i
-------
POLVCHLOflIflPTED IPHEflVLS 9-JUL-87
1336-36-3
III I I;I
6-
4-
A
I-
3
w —
In
I
A I RIW( I Mlii I C
I A O I C LAiN A S
I FM I I I QI L .L TTW FG T 1
-------
POLYCHLORI TED BIPHEflYLS
1336—36-3
g-JuL-87
I I I I II I I
U
I
p
I
V
I
P 5 E E I 00
P A POP t I II
I 0 U c no
PRc WOT L * tJ(R YOT pLa1T N CT5
C (CD
II s L
t. AIR
FM M I Ii V I
Ii VITRO m Vi’
8 —
6 —
4- —
2-
0-
—2
—4-
Lfl
F-
C
3
U i
In
0
a
1!J
0
-J
I
C
S
m VITRO
-------
POLYCHLORINATED BIPHENYLS
1336-36-3
9-JUL-87 PAGE 51
Ni. TEST ENO
00E POINT
RESULT RESULT DOSE REF ENIC
NO ACT ACT (HIDILED) NI.i 8ER NUMBER
SHORT CITATION
PLOT
DESCRIPTION TEST 0DES IN PHYLOGENETIC C E*
Pro sryotft syst
P u ProØ .qs , 1n jctlon, SOS repsfr, DNA strand breaks or cross(inks
5*0 a S.t.onIt a fl’ Ii jrf%a 1*100, reverse .jtation
SAS a Sataon.tta typhi* iia TAIS3S , r.vsrs .Jtation
SA7 a Sateons(ta typhi rfia TA1537, rsvers ajtstf on
SM a SatonstLe tyhIai TAIS3S , reverse aatat lon
SA9 a SatonetLa t I.jrlia TA9S, reverse aatat Ion
BOIl • Esc* .rich1a coL I Ui2 uvrk , reverse tatIon
lr ict syst
I PU
0
-
-
50.0000
3877
00*, NAKA*JRA, OK! 219, ¶985
2 PU
0
-
-
0.0000
3739
60109
QUILLARDET, DE BELLECONBE & HOFNUNG 79. 1985
3 SM)
B
•
-
5000.0000
84
31926
BRUCE & PEDDLE 319, 1979
4 5*0
6
-
-
167.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1, 1984
5 SAC
6
•
-
100.0000
3749
45218
SCHOEKY 45, 1982
6 5*0
6
•
-
250.0000
3875
34005
SCNOENY, SMITH 8 LOPER 125, 1979
7 SAD
6
0
-
100.0000
1988
30038
HSIA, UN & ALLEN 485, 1978
5 5*5
6
-
-
167.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1, 1984
9 5*5
6
-
•
250.0000
3875
34005
SCHOENY, SMITH & LOPER 125, 1979
10 5*5
6
0
-
100.0000
1988
30038
HSIA, LIN & ALLEN 485, 1975
11 5*7
6
-
-
167.0000
1763
58507
DUNICEL, ZEIGER, BRUSICK 1, 1986
12 sA7
6
-
•
250.0000
3875
34005
SCHOENY, SMITH & LOPER 125, 1979
13 SAT
6
0
-
100.0000
1988
30038
HSIA, tIN & ALLEN 485, 1975
14 5*8
6
0
+
100.0000
1973
23592
WYNOHAII, DEVENISH, SAFE 563, 1976
15 5*8
6
-
-
167.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1. 1984
16 SM
6
-
-
2500.0000
3876
34305
SHANIM, ANDRILLON, GOETZ 327, 1979
17 SA9
6
-
-
5000.0000
86
31926
BRUCE & PEDDLE 319, 1979
18 5*9
6
-
167.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1, 1984
19 5*9
6
-
-
100.0000
3749
45218
SCHOENY 45, 1952
20 5*9
6
-
-
2500.0000
3876
34305
SHANIN, ANORILLON, GCETZ 327, 1979
21 5*9
6
-
-
250.0000
3515
34005
SCHOENY, SMITH & LOPER 125, 1979
225*9
6
0
-
100.0000
1988
30038
HSIA, UN 8 ALLEN 485, 1975
23 BOIl
6
-
-
167.0000
1763
58507
DUNKEL, ZEIGER, BRUSICK 1, 1986
24 DISC
C
-
0
250.0000
3596
NILSSON I RAISEL 319, 1974
25 0MB
A
-
0
375.0000
2001
34221
RANEL & MAGMUSSON 59, 1979
26 01*
0
-
0
98.1000
532
50861
SINA, BEAM, DYSAIT 357, 1983
27 Ui,
0
-
0
16.3000
1913
31952
P*OSST , NCNANON, KILL 11, 1951
25 L*P
0
•
0
20.0000
1029
45810
ALTKAUS, LMENCE, SATTLER 3010, 1982
29 TCS
T
-
0
50.0000
10014
34714
PIENTA 175, 1950
30 CML
C
-
0
220.0000
3595
10171
NOOPINGARNER, SAIRJEL, KEMJSE 155, 1972
31 N’M
N
-
0
15000.0000
54
31926
BRUCE & HEDOLE 319, 1979
32 MVN
N
(.)
0
100.0000
901
45028
W*TANAAE, NOMBA, KAYASNI 43, 1982
U CBA
C
-
0
5000.0000
3593
20054
GREEN, CARR, PALMER 14, 1975
34 CU
C
-
0
40.3000
10060
27152
GARTHOFF, FRIEDMAN, FARBER 769, 1917
35 COG
C
-
0
40.3000
10060
21182
GARTHOFF, FRIEDMAN, FARBER 769, 1977
36 DIR
C
•
0
2500.0000
3594
20700
GREEN, SAURO, FRIEDMAN 507, 1975
37 DIR
C
-
0
0.0000
3574
51551
SAGAR 76, 1983
DISC a DrosoØ 1 La ..Ianogaster, chrc.os L aberratIons
a Droso ii La .etanogast.r, snetqtoldy
-------
AnimaL ceLLs in vitro
a DNA strand breaks, croset. or ret, damage, animaL ceLLs in Vitro
URP a Unsche .iLed DNA synthesis, rat primary hepatocytes
ics a CeLL transformation, Syrian hanmter eabryo ceLLs, ctonat assay
Htman ceLLs in vitro
C m. a Chromosomat aberrations, htanan L hocytes in vitro
AnimaL in vivo
MVW a Micronucleus test, mice in vivo
C a Chramosomat aberrations, animaL bane marrow caL La in viva
CGG a Chr scmaL aberrations, spermatogonla treated in viva and gonia obs.
DIR a Dominant LethaL test, rats
ENDPOINT INDICATIONS
a DNA d g. R a Reca ination G a Gene im tation S a SCE N a MicronucLeus
a Chromosome aberration A a Anet toidy T a Cell transformationF a Body fluids a Hostmediated assay
-------
I
J9 N .T CITE CR Q’ TE
2,3,7,
iflicting results have been rep rtect fran studies of d’trat sa l
aberratia s in peripheral blood lyn*ccytes of irxlividi als exposed to
T D occupati ally or as a result of irx ustrial acc ideits. ? b
oonv1ncir evid e for the inductiai of chra ,e-rat1a s was
obtained in a study of abortuses of s nen ac ci4enta1ly to ‘ t :o.
TC1 4 ) did not induce daninant lethaL “-aticns th scv 1
aberrations, inicronuclei. or si t t &sra tid exdlarqes in rodents in
vivo . It did not induce trans f n ise /2 cells but did
enhance 4tX3—induced trnsfoiiiution (P ber thy et 19 5). Tn
another study using t i* s i cell t Pe I it 4 t inhibit intercellular
nI. u.cation. Lt. s 1Tut d c to lyn a cells bit did not
induce ixisd eiu1ed. ynthes is ut rat h tocytes. T( )O was not
nuta : :: ia : ::::::. :
V to aphs , , 4 t; 1.. 4 , 211, 23R
-------
Q i x*u i 3 1 !- Io 3 o - t (Tc )
No. _____
Subgroup ______
kin-siaim 1tan ay t
ul tiaA syst
-. -- -T..7?
P dca- b. karyotes
ryote8 -
ant te
- —
lnv4tro
- -
----
Invivo
JA 3Mfl
Non-ht un
D GD
Al
D
G
C
A
D
U
C
A
D
S
14
C
A
T
I
D
Q
S
j
C
AT
D
U
S
14
C
A
iL
D
U
S
14
C A
::
::
:
:
:
:
:
:
:
:
:
:
:
:
?
:
:
:
:
::
:
:
=
=
:
=
:
z-
D. WA damage; U, gene nutaticn; C. d’Ira,K ecin l aberratt s S. sister chrcanat.td e Cd* es. A. ar up1oidy. T cell
txansfoxnatton, IL, dmin nt lethab II, micronuclei; k, mitotic r I4nat±OiOr gcje mversioqs ibitiou of intercellular
-* • uiicaUcm : : :
-------
TCDD, 2,3,7,8- 9-JUL-87
1746-01-6
8 -
4-
Ln
I .-
2-
: 3
w
Ui
0 . 111111
—2 -
A i A
—4. —
I I —
L v t
D5, I I I
I FM I I I ‘ I I I I
-------
9-JUL-82’
tj
I—
w
In
0
0
I D
0
-J
S
P VOT S LOU JC OTE5 R1T$ I GC1
I
C
I
I b1 S ii
a:
L v
If’
I4X FM Ii U
Ni UIT Ii UI
TCDD, 2 ,3,7 ,8-
1746-01-6
i i i i i
II
8- —
6- —
4- —
2- —
0- —
-2- —
—4- —
A /M
-------
TcDo, 2,3,7,8-
1746-01-6
9-JUL-87 PAGE 52
NR. TEST END
CODE POINT
RESULT RESULT DOSE REF EHIC
NO ACT ACT (HID/LED) NUMBER NUMSER
SHORT CITATION
PLOT
DESCRIPTION TESICODES IN PIIYLOGE1IETIC ORDER
Prokaryotlc syst
MO a Ss&.o n stLa t iuiajrit TA100, reverse .utatfcn
SAS • Sat.ønelta t li.jriia TA1535 , reverse .jt•tlan
SAT a Salmonella typI i.jriia TA1537 , r rs. .jtatian
$48 a Salmonella typñlairiia TA1S3S , reverse .jtation
5*9 a Salmonella ryøli.riia TA9S , reverse ..it.tlon
• SalmonelLa t nmorIia (other sc. strains), reverse motation
MIl eelS In vitro
LRP • LN *CI i JIUd D NA synthesis, rat primory hep.tocyt.s
GST a Gins tatlon. mouse LS17BY cit Is In vitro, 7K Loc a
a Gin. . tatlon. moim. L5IThY cells In vitro, alL other (cci
701 a c (( trvusfoftlon, c3NIOT1/2 mouse cells
AnlL in vivo
1 5*0
G
0
-
10.0000
2249
41220
GEIGER & NEAL 125, 1981
2 5*0
C
-
-
500.0000
3718
56690
MORTELMANS, HAUORTH, SPECK 137, 1984
3 SAO
C
0
-
10.0000
3749
45218
SCHOENY 45, 1982
4 5*5
C
0
-
10.0000
2249
41220
GEIGER & NEAL 125, 1981
S SAS
C
-
-
500.0000
3718
56690
MORTELMANS, HAUORTH, SPECK 137, 1984
6 5*5
C
0
-
10.0000
3749
45218
SCHOENY 45, 1982
7 SAl
C
-
-
10.0000
2249
41220
GEIGER & MEAL 125, 1981
8 SAT
C
-
-
500.0000
3718
56690
MORTELMANS, NAWORTH, SPECK 137, 1984
9 5*7
C
0
•
10.0000
3749
45218
SCHOENY 45, 1982
10 SM
G
0
-
10.0000
2249
41220
GEIGER & NEAL 125, 1981
11 5*9
C
0
-
10.0000
2249
41220
GEIGER & MEAL 125, 1981
12 5*9
C
-
-
500.0000
3718
56690
MORTELMANS, HAHORTN, SPECK 137, 1986
13 5*9
C
0
•
10.0000
3749
45218
SCHOENY 45, 1952
14 5*5
C
0
-
10.0000
3749
45218
SCHOEMY 45, 1982
15 im
0
-
0
0.0600
956
1075
PIENTA & KAWALEK 243, 1981
(NO)
16 GST
C
•
0
25.0000
2316
48369
ROGERS, ANDERSEN, BACK 445, 1982
17 GS1
C
•
0
0.0500
2316
48369
ROGERS, ANDERSEN, BACK 445, 1952
18 TOS
I
-
0
1.6000
3753
15033
ABERNETNY, GREENLEE, NI ANO 651, 1985
19 SVA
S
-
0
0.2000
2546
49522
ELIGERMAM, WILIER & EREXSON 277, 1982
(NO)
20 SYR
S
-
0
0.1500
2634
60191
NEYNE, ALLISON, BOSE 63, 1985
(NO)
21 MVN
N
-
0
0.1500
2634
60191
MEYNE, ALLISON, BOSE 63. 1985
(NO)
22 CKA
C
-
0
0.1500
2634
60191
MEYNE, ALLISON, BOSE 63. 1955
(NO)
23 CIA
C
C-)
0
0.0020
2201
29012
GREEN. MORELAND £ SNEU 292, 1977
(NO)
24 CU
C
-
0
0.0200
3732
20520
GREEN & MORELAND 1975
(NO)
25 DLI
C
-
0
0.0050
2337
16733
EIIERA & Rt 0 ICE 70, 1973
(NO)
26 C L I
C
-
0
5.0000
2275
36718
REGGIANI 27, 1950
27 CLI
C
( )
0
0.0000
3751
CZEIZEL & KIRAI.Y 239, 1976
28 CVN
C
C)
0
0.0000
3748
50137
TENC1IINI, CRINAl 0, PACCNETTI 73, 1953
29 ICR
-
0
0.0100
3750
41626
OREIKO, ABERNETNY, SANCHEZ 1095, 1956
(NO)
a Sister chroestid .xchinge, infest cells In vivo
-------
TcDD , 2.3,7 8- 9-JUL-87 PAGE 53
1746-01-6
MVM a Micronucleus test, mice in vivo
c3A a Chromosomat aberrations, animal bone marrow cells in vivo
DL a Dominant Lethal test, rats
Ht afl in vivO
Cui Chromoscust aberratiøns, human l hocytes in vivo
CYN s Chromosom.L aberrations, other human cells in vivo
Alternative testcodes (not included in profiles)
IC R a Imibition of intercellular coeauss ication , rodent in vitro
ENDPOINT INDICATIONS
D a DNA damage R a Reccatination G a Gene mutation 5 a SCE N * Micronucleus
C a Chromosoma aberration A a Ane loidy a Cell transformationF a Body fluids I I = I4ostmediated assay
-------
a
.I n ao 1r E1 C3 NOT CITE CR 2:TE
In a sti y, tetrad tloroethyl e did rct irxiuce diratosai l
aberrations or sister chraiatid exdianges in lyrT ccytes frQu persons
Occupationally exposed to l centrations.
Tetrac*tloroethylene irx uced st g in Lt erarx1 kidney
cells of mice treated in vivo . It ixiix et transfo tion in zat rbryo
cells bit r t in BAT.B/c3T3 cells ar I did t ir,ii* e Uns&eduled i m
synthesis in rat hepatocytes. Th irduced r essi ,e lethal rTutations in
Droso *u.la . Tetradiloroethylsgi. iz xet g v rsLat aM tm.totic
recaT*)inati.on in yeast in one atth J t.thde*’ iiti In ‘*wth levels of
aMogercus cytochr P45w s re tt rs t nutagenic to yeast
in vitro or in t-mediated’ assay M s rot nutagenic to plants or
bacteria.
L 1 ‘ gra * , 491. & p1. 4 , 243
-------
lon-sia imi tian .y.tai
------ -
Proka- ikaryotes
ryoteB
Marmat Ian yatai
- ---—— —---- -
4 ttro Invivo
— ——— --
-— i —i -—
Planta
————-- — ——
Insects
——--— ——
Uon-hI2 fln
—- - ——
Ikxn n
Non-hunan
Ikx n
A
:
;
:
:
:
;
:
:
;
:
;
;
;
;
;
;
;
:
;
:
:
;
;
;
:
:
;
:
;
:
:
:
—
—
,.
÷1
1
— -
.
.e
•3• I
p4 , ,.
p
a
e
a
-tl
a.
a
a
1
,_
,,
_
.,:
.
D. EZ damage; (3, gene nutation; C, chraIK)SQML aberrations; S, sister chran itI4 exchanges; A Euleuploldy, T. cell
twwfoazatizi. IL, daninant leLhaJ H, micronuclei; B, mitotic rexxiibthatlon or gene a version;:1, trthib ition of intercellular
• : :::: .:: :: ::
a i
Ho.
Sub3r ip -
-------
TETRPCHLOPOETHYLEflE 9-JUL-87
127—18-4
B— I I I I I I I I
6. —
4. —
Ui
I—
2-
3
L i i
U I
0
o O 1. :
o - -
-2
I t
-4. A
N S 5E S I
I NffiA( ( I I
I O IK N N I
FM I I ‘ I
-------
9-JUL-B?
Lfl
I —
C
w
U i
0
U
1!.1
0
-j
8 .
6
4.
2
U
TETRRCHLOflOETHVLEflE
12?— 18-4
-------
TETRACI4LOROETHYLENE
127-18-4
9-JUL-87 PAGE 54
NE. TEST EI
C00E POINT
RESULT RESULT
NO ACT ACT
DOSE REF ENIC
(HIOILED) MJMBER NIJ 8ER
SHORT CITATION
PLOT
DESCRIPTION TESTCODES IN PHYLOGENETIC ORDER
Prokoryotic syst
5*0 a Sat.onstts typI i*iriia TAIOO, rvorsl aitat cn
5*5 a $M.onett. t f.jr a TAIS3S , r rs.i aitation
5*7 a St.ons( La tp isit. TA1537, rsversa aitatlon
SA9 a St.onstta tyØ iairita TA9S , rvsrss aitatlon
E X a Esctierichi. coIl K12, tonard or ravers ..itation
Lower .I.*aryotic syst
scG a S.cchar yces C.r,vI s ss, none conversion
SCN a 5• cerevfsies, ho.ozygosis by rico in.tion or ‘ens conversion
ScR a Sacch.rc.yc.s cerevi si as, rsverse aitat ion
P’ant syst
T a Trad.scantla sped.., aitation
Insect syst
DIRt a Drosophila astanogistor, s.x-Ur*.d recessiv, Lethal sitation
*ni L cells in vitro
1 SAO
0
0
-
660.0000
208
31292
BARTSCH, MALAVEILLE. 8ARBIN 249, 1979
2 SAO
0
-
-
166.0000
638
52195
HAWOETH, LAWLOR, HORTELMAIIS 3, 1983
3 SA5
C
-
-
166.0000
638
52195
HAUORTN, LAWLOR, MORTELMAMS 3, 1983
4 5*5
G
-
0
50.0000
2583
46333
KRINGSTAD, LJUNGOUIST, DE S JSA 562,
1981
5 SA7
C
-
•
166.0000
638
52195
HAWORTH , LAWLOR, MORTELMAMS 3, 1983
6 SA9
C
-
-
166.0000
638
52195
HAWORTH, LAWLOR, MORTELMANS 3, 1983
7 ECIC
C
-
-
149.0000
33
24782
GREIN, BONSE, RAOWAN 2013, 1975
8 ECX
0
0
-
99.0000
34
29015
HENSCHLER 61, 1977
9 5CC
R
•
0
1100.0000
10035
34332
CALLEN, WOLF & PHILPOT 55, 1980
10 5CC
R
-
-
3300.0000
3275
48880
BRONZETTI • BAIlER, COESI 323, 1983
11 sa l
1
•
0
1100.0000
10035
34332
CALLEN, WOLF & PHILPOT 55, 1980
12 SCII
R
-
-
3300.0000
3275
48880
BRONZETTI, BAIlER, CORSI 323, 1983
13 5CR
C
-
0
810.0000
10035
34332
CALLER, WOLF & PHILPOT 55, 1980
14 5CR
C
-
•
3300.0000
3275
48880
BRONZETTI, B*UER, CORSI 323, 1983
15 TSM
C
•
0
6.9000
10082
45839
SCHAIRER & SAUTKUI.IS 154, 1982
16 DIRt
C
-
0
6400.0000
10089
60166
VALENCIA, MASON, WO00RUFF 325, 1985
17 URP
D
-
0
0.0000
3552
64061
SHIMADA, SWANSON, LEBER 159, 1985
18 TIM
T
-
0
250.0000
2150
1446
TU, PEJRRAY, HATCH 85, 85
19 TIE
T
•
0
16.0000
10071
384
PRICE, MASSETT $ MANSFIELD 290, 1978
20 IRRt
II
-
0
2.6000
3273
41880
BRONZETTI, $AUER, CORSI 323, 1983
21 DVA
0
•
0
664.0000
3636
62953
WALLES 31, 1986
22 SLN
S
-
0
0.6000
3277
34438
IKEDA, KOIZIJIL, t&ATANABE 251, 1980
23 C1.N
C
-
0
0.6000
3277
34438
IKEDA, KOIZISII, WATANAIE 251, 1980
(NO)
(NO)
a Unsc* .ójted DNA synthesis, rat pri ry h.p.tocyt.s
-------
TETRACHIOROETHYLENE 9-JUL-87 PAGE 55
127-18-4
I BM • CeLL transformation, BALB/C3T3 mouse ceLLs
TRR CeLL transformation, RLV/FISCHER rat eabryo ceUs
Body fLuid and host mediated assays
HMM • Host mediated assay, microbiaL ceLLs in animaL hosts
AnimaL in viva
DVA • DNA strand breaks, crossL or ret. d ge , animaLs in viva
Ht.aen In viva
SIN — Sister chromatid exchange, hi.m.n Lyw iocytes in viva
CLH • Chromosomet aberrations, hi.n L flocytes in viva
ENDPOINT INDICATIONS
D • DNA d ge R z RecosCination C • Gene imitation S • SCE M x MicronucLeus
C • Chromosom, aberration A • Anet Loidy T • CeLL transforwationF s Body fLuids N • Hostmediated assay
-------
* 1 g I
TRIa) YL 4El DO TWT CITE OR Q E
b edeqjiate data re available i the genetic and related effects
of tridtloroethylene in hix ens.
P ny cc ii rcial preparatiats of tridüoroethyI e tain
stabilizers bith are kr to be a rule;: :the ; urities of
preparatia s tested are r t given. Tid 3.’oroethy1ene i.nducec
microriuclei, s tic rTutat1 (in the t test) a i tt strath freaks
in the kidney and liver, but not g, of tt4tie. t eated in vi.vo ; it did
rct induce tiam.nant lethal nutaticrn . It s pcit ve in a e test ai
sperm TTor kclogy in nu.ce. tt irx øad sister rai t zt exdianges and
sdtetiuled rtTh synthesri in htr n 1pl cytee m vitro . It induced
transfoi uicitia j3 W 1 ise a I t cells but r t in cyriart bert ter cells.
It did rct irylucej. d tjji exd a iq s in ( dnese han ter cells in
vitro or d iled L!& .synthesi3 in rat be tccytes. It was nutagenic
to plân 3 1ls : :*t ta iQ , gene tversicrt and mitotic
re.itbinatiocz 3 ar . rces erevisiae in both in—vivo and
bost-nediated aasqs, but tmitati was r t induced in
Sthizosa arQW in vitro or in a boet-cnediated assay. It ‘ B
zT11ta ic to bacteria t en tested as a gee but r t ‘ ,* en tested as a
liquid, exc t in a e sti.rly using a ncuse—liver nstabolic syst n.
1 Th !tnoqraE s , II , 263; 2°f, 545; Suppi. 4 , 247
-------
&n-wdøso 1Lan .y tan8
Mm%1L k .* jat h
—-- i 4I4+W+ - -- -. --
Pnka- ukaryotes
ryotea
Plants lnaecta
— — — — — - — — — - — —
r vitr —
Invivo
--fllFflU rr 1 1p . -
IkuMn Non-hilnan
— - - — — — —. — — —
--
Ilinan
— — — — — —
DGD
AI
D
0
C
A
D
0
C
A
D
S
14
..
T
I
.,.
D
43
S
Ii
(
AT D
.
G
S
14
C
A
IL
D
G
S
14
C A
:. :
:
:
:
:
:
i
2:
:
:
:
:
::
:
:
:
?
:
:
:
:
:
:
:
::
12I dainage; 0. gene ni t.ati ; C. d ra u6anal aberr ttone; . : ; A. azieiaploidy. T. cell
tranafoxinatic-zs, IL, dcuiinant lethab H, snicrcniclei; k, mitotic re i ina 4 ç: qt 9ci) :t nversion of intercellular
O3 —
4.
Sub3ro. p -
-------
TRICHLOflOETHYLEflE 9-JUL-87
79-01-6
8— NO H % S I I U’ I
6
A
4. —
Lfl
I-
2
L AA’
—4.
U S S .D
0 I I L C
p s r C
I - I I I I J c i T c rai
-------
TflICHLO ROETHVLEflE
79-01—6
S El El S I I
• mc anc ii s
I El GI F I
I I I
9-JUL-87
I I I
8. —
A
4.
w
E 2.
w
Lfl
0
o 0-
w
0
-J
-2-
—4- —
S S U S I I
I 2 A I C L
S F P C S I
( YOT L £U( WOT 5 P 1TS N C1 m vimo 4a FM m —
m vn v
-------
TRICHLOROETHYLENE
9-JUL-87 PAGE 1
DESCRIPTION TESTCODES IN PIITLOGEJIETIC ORDER
Prokaryotlc syst
SAO • Sat.cnei La tyhijriua TAIOO, reverse itat$on
US • Sat.onetia typñi.Jri a TA1535, reverse itatfon
SA9 - SsL neL Li typI f..ari a TA96, reverse .atat ion
SAS a S.iaoneLta typñiamjriia (other •isc. strains), reverse sitation
a Escherichia coil K12, forward or reverse .utation
L e, . suk.r) .Otic syst
79-01-6
HR. TEST
END
RESULT
RESULT
DOSE
REF
EMIC
SNORT CITATION
PLOT
CODE
POINT
NO ACT
ACT
(HID/LED)
NIJI8ER NLS IGER
1 SAO
C
-
.
0.6000
155
27123
SIPhON, KAIJHANEN & TARDIFF 249, 1977
2 SAO
C
-
+)
265.0000
208
31292
BARTSCH, NAL.AVEILLE , BAR3IN 249, 1979
3 SAO
C
-
-
526.0000
2116
27480
SASKELL 141, 1978
4 SAO
C
-
c+)
53.0000
2127
31626
BADEN, KELLEY, MAiZE 417, 1979
5 SAS
C
-
0
50.0000
2583
46333
KRINGSTAD, LJUNGOUIST, DE SOUSA 562,
1981
6 SA5
C
-
-
526.0000
2127
31626
BADEN, KELLEY, MAZZE 417, 1979
7 SAS
C
-
-
131.0000
3552
64061
SHIMADA, SUANSON, LEBER 159, 1985
8 SA9
C
0
(+
0.5000
1193
39506
NORPOTH, REISCH, HEINECICE 312, 1980
9 SA9
G
-
-
100000.0000
2116
27480
WASKELL 141, 1978
10 5*5
C
0
•
13.0000
3687
67578
MIYATA, NONMI, YOSHIKAWA 60, 1986
11 ECI(
C
-
C .)
436.0000
33
24782
GREIM, BONSE, RADUAM 2013, 1975
12 5CC
R
•
0
2000.0000
10035
34332
CALLEN, WOLF & PHILPOT 55, 1960
13 3CC
R
-
•
3900.0000
2125
29054
BRONZETTI, ZEIGER, FREZZA 411, 1978
14 SC!!
R
•
0
2000.0000
10035
34332
CALLER, WOLF & PHILPOT 55, 1980
15 *80
R
C•)
0
39.0000
2621
58862
CREBELLI, CONTI, CONTI 105, 1985
16 5CR
C
•
0
2000.0000
10035
34332
CALLEN, WOLF & PHILPOT 55, 1960
17 3CR
C
-
+
26000000
2125
29054
BRONZETTI, ZEIGER, FREZZA 411, 1978
18 SZF
C
-
-
2900.0000
1349
53089
ROSS I, MIGL lORE, BARALE 75, 1983
19 A!!F
C
C.)
0
13.0000
2621
58842
CREBELLI, CONTI. CONTI 105, 1965
20 T I
C
•
0
0.5000
10081
51343
SCHAIRER & VAN’T NOF 1, 1978
21 URP
D
-
0
131.0000
3552
66061
SHIMADA, SWANSON, LEBER 159, 1965
22 SIC
S
0
-
9.0000
2128
33288
WHITE, TAKENISA, ECU 426, 1979
23 THR
T
C.)
0
250.0000
2150
1486
Ui. PhIRRAY, hATCH 85, 85
24 TRI
T
•
0
144.0000
10071
384
PRICE, NASSEIT £ MANSFIELD 290, 1975
25 TCS
T
-
0
3.0000
1283
49916
MACHER & ZELLJADT 291, 1983
26 UlI !.
0
•
•
2500.0000
811
41437
PEROCCO 6 PROD! 213, 1961
27 SN!.
S
•
0
178.0000
2612
66374
9.1, SELE, CI!ARA 105, 1981
28 III!
N
•
0
400.0000
2125
29054
BRONZETT1, ZEIGER, FREZZA 411, 1978
29 PhI!
N
•
0
2000.0000
1369
53089
ROSS!, MIGLIORE, BARALE 75, 1983
30 OVA
0
-
0
2000.0000
2221
1,6318
PARCIN4AN & hAGER 197, 1982
31 OVA
0
•
0
500.0000
3636
62953
WAU.ES 31, 1966
32 MST
C
•
0
140.0000
524
26409
FAHRIG 87, 1977
33 MV II
N
•
0
750.0000
2614
41577
OUPRAT & GRADISEI 182, 1980
36 DL II
C
-
0
3500.0000
2615
34821
SLACIK-ERBEN, ROLL, FRANKE 37, 1980
35 SI.!!
S
C.)
0
0.0000
2612
46374
91, SELE, CH$ARA 105, 1981
36 5PM
•
0
2500.0000
2076
41114
LAND, OIER, LINDE 53, 1981
(NO)
5C a Saccharo.yces c.r.visiae, gene conversion
SC M • S cerevisia., ho.ozygo.is by reco ination or gen. conversion
-------
TRICHLOROETHYLENE 9-JUL-87 PAGE 2
79-01-6
MG Aspergittus nidulans, genetic crossing-over
SCR a Saccharontyces cerevisise, reverse ,m.Itation
SZF Sch I zosaccharomyces pcnte, forward nnItat ion
ANF a Aspergiltus nidulans, forward smJtation
Plant systema
ISM a Tradescantia Species, mjtation
Animal celLs in vitro
URP Unscheduled DNA synthesis, rat primary hepatocytes
SIC a Sister chromatid exchange, Chinese h ter cells in vitro
IB M Cell transformation, BALB/C3T3 mouse cells
ICS a CelL transformation, Syrian hameter eetryo cells, dlonal assay
TRR a Cell transformation, RLV/FISCHER rat eatryo cells
Nusan cells in vitro
UHL a Unscheduled DNA synthesis, huw Lyuçhocytes in vitro
SHL a Sister chromatid exchange, human Lyw hocytes in vitro
Body fluid and host mediated assays
11114 a Host mediated assay, microbial cells in animal hosts
Animal in vivo
DVA a DNA strand breaks, crosst. or ret, damage, animals in vivo
lIST a Mouse spot test
a Micronucleus test, mice in vivo -
DIM a Dominant lethal test, mice
Ntman in vivo
5tH a Sister chromatid exchange, ht lysphocytes in vivo
Alternative testcodes (not included in profiLes)
5PM a Sperm morphology, mouse
ENDPOINT INDICATIONS
D a DNA damage a Reco ination G a Gene itation 5 a SCE N a Micronucleus
C a Chromosome aberration A a Aneuploidy T a Cell transformationF a Body fluids H a Hostmediated assay
COTS1]’
-------
C3 N3T CITE OR Q!2TE
O ratcsa al aberratia is re induced in periØ era1 blood
l * cytes of rkers exposed to vinyl, chloride at levels of 5_ Ø pan.
¶I\ o sttrUes reported negative results for sister ditüi id exchanges in
exposed i rkers, ile in aother sttxiy a ‘ ‘ ‘was
Vinyl chloride ir*iuced thratcsat 1 -rrat1a s, sister thr tid
exchanges and micrcnuclei in r vi ts exposed it vivo bit did rct induce
uutati s in the u ise spot test or * itnent l.e fl tatiQ s in rats or
mice. It alkylated t in severat ti,sue of mice axx 1 rats exposeri in
vivo . Vinyl chiori4e 4 d sist t c %rce tid d- anges in ht ,ran
1 ç* cytes cells and sc*teduled
t*Th synthesis in p4tQ teS. It indc ti cell tmnsfoz ti in
““ ian ha ter cells. It induced
recess i1U ê thal t51t ti is, b t ot aneriploidy, heritable trans locations
or daiu.nant lethal ta i. s in t oec**1Lila . It s nutagenic to plants
and to Schizo dir”i r& e bit r t to other fungi; it induced gene
version in ye 1 danage and nutation in tacteria.
Vinyl. chloride bo x d ,valently to isolated t Th in the presence of a
natablic system.
Mrcç ra ts, 19, 439; Su l. 4 , 262; 39, 195
-------
-ewe
kn-sua mtian ayatei
Main e4t k) yata1
-- —• -. - .-i::- - -- —--——
Ptdca- F .*karyotea
ryote5 _
5
n uttro
--
Invivq
--- — —
D GD
;
A1
D
0
C
A
D
0
C
A
o;
S
H
‘I
I
(
Q
S
H
AT D
0
S
Ii
C
A
IL
D
0
s
is
C A
:i
:
:
:
:
:
:
:
=
::
=
=
:
=
:
:
!
:
:
D. I}1h damage: 0 ger iaitaticn: C. d ra1E 36ana1 aberratians; S. siatøt ch exd ** ee; A. aót: a 3.Qjdy •
trangtoxmattcn. IL, & ninant lethab H, inicrcnuclei; R, mitotic r r gene bonvezsic iz I 4 th dbition of Intercellular
— I I d&/ d
No.
Subgroup -
-------
VIflYL CHLOflIDE JUL 87
76-01—4
— I : 555 SE
6 -— —
4.— — —
A
I ør I I I I I I I -
-------
9-JUL-87
I I I
I I
a ssss S S I I I V S
if AIAI C 2 5 I im S H
II. 03S51 F I I P01 I S L
I S S fl
S 01 C C C II
U H A F Ill
PqQ( YOT L I
-------
VINYL CHLORIDE
15-01-4
9-JUL-87 PAGE 1
NA. TEST END
CCCE POINT
RESULT RESULT
NO ACT ACT
DOSE REF EMIC
(HID/LED) NIJ4BER NIJ4BER
SHORT CITATION
PLOT
I ECO
0
0
•
10.0000
586
31442
ROSENKRANZ & LEIFER 109, 1980
2 Ed.
0
0
•
2.5000
586
31442
ROSENKRANZ & LEIFER 109. 1980
3 350
0
-
0
663.0000
97
23138
ELI4ORE, WONG, LALJM1ACH 405, 1976
4 350
0
-
0
0.0000
187
29335
LAUNSACH, LEE, WONG 155, 1977
5 SAO
C
0
-
1250.0000
47
29183
ANDERSON I STYLES 924, 1978
6 SAO
6
0
•
0.0000
193
30018
JONES & HATHAWAY 1, 1978
7 SAD
6
-
0
663.0000
97
23138
ELMORE, WONG, LAIJ4SACN 405, 1976
8 SAD
6
•
•
492.0000
155
27123
SDI4ON , KAUHANEN & TAROIFF 249, 1977
9 SÃO
6
0
( •)
0.0000
208
31292
BARTSCH, MALAVEILLE, BARBIN 249, 1979
10 SAC
S
4
4
500.0000
10007
30971
SINAON & TAROIFF 417, 1977
11 SÃO
6
-
0
0.0000
187
29335
LALJ4BACN, LEE, WONG 155, 1977
12 SAC
6
•
•
500.0000
87
21347
MCCANN, S1*OW, AMES 3190, 1975
13 SA3
C
-
•
1500.0000
1051
63232
DUVERGER-VAW BOGAERT, LAMBOTTE-VANOEPAER 35,
1982
14 5A3
6
(•)
•
50.0000
354
41726
PONCELET, DE MEESTER 63, 1980
15 SA3
C
•
•
5.0000
60
20131
BARTSCH , MALAVEILLE & MONTESAJIO 429, 1975
16 543
S
0
•
500.0000
208
31292
BARTSCH, MALAVEILLE, BARBIN 249, 1979
17 SA3
6
0
•
250.0000
848
37817
MALLSTRON, SUNOVALL, RAN JG 129, 1981
18 SAS
6
0
-
1250.0000
47
29183
ANDERSON & STYLES 924, 1978
19 SA5
C
-
•
283.0000
48
18068
RAN*JG, JOHANSSON, RAMEL 194, 1974
20 543
G
0
•
2.5000
60
20131
BARTSCN, MALAVEILLE & MONTESANO 429, 1975
21 5*5
C
•
•
0.0000
87
21347
MCCANN, SIPICN, AMES 3190, 197$
22 SAS
C
0
•
123.0000
193
30018
JONES & HATHAWAY 1, 1978
23 US
C
•
•
9.8400
96
22871
ANDREWS, ZAUISTONSEI & VALENTINE 273, 1976
24 SAT
6
0
-
514.0000
48
18068
RANNUG, JOHAMSSCN, BAllEt 194, 1974
25 SA5
C
0
-
514.0000
48
18068
RANNUG, J0NANSSON, BAllEt 194, 1974
26 SA l
C
0
-
1250.0000
47
29183
ANDERSON & STYLES 924, 1978
27 5*9
6
0
-
1250.0000
47
29183
ANDERSON & STYLES 924, 1918
2$ 5*5
6
0
-
514.0000
48
18068
RAIOJG, JOIIANSSON , RAIlEL 194, 1974
29 US
6
0
•
50.0000
60
20131
BARTSCN, NALAVEILLE & MONTESANO 429, 1975
30 ECE
C
-
4
660.0000
33
24782
GREIM, BONSE, RAOWAN 2013, 1975
31 500
A
-
4
3000.0000
69
22339
LOPRIENO, 9ARALE, BAUER 85, 1976
32 SCG
A
-
•
62.5000
846
41155
ECKAROT, PIJLIAWAN, DE RUITER 381, 1981
33 SON
A
-
0
13.80CC
67
22870
SHAHIN 269, 1976
34 5CR
C
-
0
13.3000
67
22870
SMANIM 269, 1976
35 SZF
C
-
•
1000.0000
69
22339
LOPRIENO, BARALE, BALER 85, 1976
36 NCF
C
-
-
1280.0000
106
24427
DROZDCWIC2 & NUANG 43, 1977
37 TSM
C
4
0
0.1870
942
48255
SCHAIRER, SAUTEULIS, TEMPEL 123, 1982
38 T
C
•
0
0.0630
56
31304
SCHAIRER, VAN’T IOF, HAYES 421, 1978
39 ONE
C
•
0
25.6000
194
29118
MAGNUSSON & RAIEL 307, 1978
40 DM11
C
•
0
2.1800
180
24894
VERBURGT & VOGEL 327, 1977
41 DIMS
C
-
0
76.8000
130
24894
VERMSJ4GT & VOGEL 327, 1977
42 DM1.
C
-
0
76.8000
180
26894
VERBURGT & VOGEL 327, 1977
43 DIMS
A
-
0
76.8000
180
24894
VERBUACT & VOGEL 327, 1977
44DMN
A
-
0
500.0000
2001
34221
RAMEL & MAGMJSSON 59, 1979
45 taP
o
•
0
125.0000
3552
64061
SNIMADA, SWANSON, LEBER 159, 1985
46 CCC
C
-
•
750.0000
929
48256
ERANN, BARSEY & MCCOOEY 91, 1982
47 5911
6
-
4
250.0000
25
31667
DREVON & KUNOKI 173, 1979
48 690
C
-
•
250.0000
25
31667
DREVON & KUROKI 173, 1979
49 TBK
T
•
0
0.0200
2150
1466
TU, **RAY, HATCH 85, 85
50 TTS
T
•
0
50.0000
1396
51844
MATCH, MIIAY, ATER 1965, 1983
-------
9-JUL-87 PAGE 2
VINYL CHLORIDE
75-01-4
HR. TEST END
C00E POINT
RESULT RESULT
NO ACT ACT
DOSE REF EMIC
(HID/LED) NUMBER NUMBER
SHORT CITATION
PLOT
DESCRIPTION TESTCODES IN PHYLOGENETIC ORDER
Prokaryot Ic systes
ECO Escherichia coil pot A/W3110-P3478 , diff. toxicity (spot test)
ECI. Escher;chia coil pot A/W3110-P3475, dlff. toxicity (Liq. susp. test)
BS O BacilLus si. tiLIs rec strains, differential toxicity
SA0 SalmonelLa typhi rita TAIOO, reverse . tatlon
SA3 — SaLmoneLla typhi riua TA1530, reverse .jtation
5*5 — Salmonella typhin r1i.a 1*1535, reverse motation
SAT SalmonelLa typhiaJriia TA1537, reverse .jtation
5*8 SalmoneLla tyhi2.lrita TA1538, reverse .. tation
5*9 SalmoneLLa typhi*iria TA98 , reverse imitation
5*5 z SaLmonella typhieu rha (other misc. strains), reverse imitation
ECK Escherlchla coli K12 , forward or reverse asjtation
Lower eukaryotic syste
SI SHL
S
-
+
250.0000
717
41554
ANDERSON, RICHARDSON, PURCHASE 137, 1981
52 1M4
I I
+
0
700.0000
69
22339
LOPRIENO, BARALE, BAUER 85, 1976
53 HIll
H
•
0
Z5.OOOO
846
41155
ECKARDI, WJLIAWAK, DE RUITER 381, 1981
54 lIST
0
0
18000.0000
253
34364
PETER & UNGVARY 193, 1980
55 WA
S
•
0
7000.0000
356
34822
BASLER & ROHRBORN 1, 1980
56 MVII
N
+
0
30000.0000
243
34400
JENSSEN & RAIIEL 191, 1980
57 MVII
N
•
0
45000.0000
1645
52070
RICHARDSON, STYLES, BENNETT 139, 1983
58 CU
C
•
0
270.0000
909
34998
ANDERSON & RICHARDSON 261. 1981
59 CU
C
•
0
50000.0000
356
34822
BASLER & ROHRBORN 1, 1980
60 CU
C
•
0
300.0000
2476
32507
FLEIG & THIESS 557, 1978
61 DIN
C
-
0
27000.0000
68
23915
ANDERSON, HODGE & PURCHASE 359, 1976
62 DIN
C
-
0
6000.0000
1296
48987
HIMENO, OKL )A & SUZUKI 47, 1983
63 DIR
C
-
0
180.0000
44
24532
SHORT, MINOR, WINSTON 965. 1977
64 SIN
S
-
0
0.0000
717
41554
ANDERSON, RICHARDSON, PURCHASE 137, 1981
65 SIN
S
-
0
0.4000
267
36232
HANSTEEN 279, 1979
(NO)
66 SLN
S
C.)
0
8.0000
2467
31496
KUCEROVA, POLIVKOVA & BATORA 97, 1979
67 CLH
C
-
0
2.0000
57
23843
KILIAN & PICCIANO 321, 1976
68 CLII
C
•
0
200.0000
189
24116
KUCEROVA 123, 1976
69 CLII
C
•
0
10.0000
178
29135
HANSTEEN, HILLESTAD, THIIS-EVENSON 271, 1978
70 CLH
C
•
0
0.0000
190
20989
PURCHASE, RICHARDSON & ANDERSON 410, 1975
71 CZ.H
C
-
0
1.6000
559
37610
ROSSNER, SRM, NOVAKOVA 425, 1980
72 CUt
C
•
0
2.0000
560
37369
ANDERSON, RICHARDSON, IGNT 151, 1980
73 C1.H
C
•
0
0.0000
628
23906
SZENTESI, NORNYAK, UNGVARY 313, 1976
74 CLN
C
•
0
0.0000
627
20152
DUCATMAN, HIRSCHHORN & SELIKOFF 163, 1975
75 Cut
C
•
0
12.0000
626
20040
FUNES-CRAVIOTO, LAI4BERT, LIDSIEN 459, 1975
76 CLII
C
•
0
6.0000
629
29120
PURCHASE. RICHARDSON, ANDERSON 325. 1978
77 CLH
C
•
0
0.0000
2476
32507
FLEIG & THIESS 557, 1978
78 CUt
C
•
0
8.0000
2667
31496
KUCEROVA, POLIVKOVA & BATORA 97, 1979
79 BID
0
•
0.0000
3646
42544
LAIB, GWINNER 4 BOLT, 1981
(NO)
80 IVO
•
0
7.3000
3646
62544
LAIB, GWINNER & BOLT, 1981
(NO)
$1 EVO
•
0
162.5000
3647
45117
BERONAN 117, 1982
(NO)
SCG - Saccharomyces cerevislee, gene conversion
-------
VINYL CHLORIDE 9-JUL-87 PAGE 3
75-01-4
SCM a S. cerevisiae, ho zygosts by reccabinatfon or gene conversion
SCM a Saccharo.yces cerevisiae, reverse .,tation
SZF a Sch i zosaccharos ’ces p e. forward jtat ion
MCF a Neurespora crassa , forward tatian
Plait systems
TSM = Tradescantia species, i.jtaticn
Insect systems
DM1 a Drosophila melanogaster, sex-linked recessiv, lethal jtation
0MM a DrosophiLa m.Lanogaster, heritable translocation test
DM1 a Drosophila .elanogaster, dc.inant lethal test
0MM a Drosophila ..Lanogaster , enei.ploidy
AnimsL cells in vitro
IMP a lk sche jled DMA synthesis, rat primsry hepatocytes
GCO a Gene itatlon, Chinese ha.ster ovary cells in vitro
G9N a Gene jtation, Chinese ht.r lii g V-79 cells in vitro, HPQT
G90 a Gen sitatlon, Chines hamster lung V-79 cells In vitro, ousbsin
IBM a cl( transformstion, BALB/C3T3 asuse cells
T7S a Cell transformstlon, SAT/Syrian ht.r ryo cells
Mt.n cells In vitro
SIlL a Sister chrcmstld exchange, hi l hocytes In vitro
Body fluid and host .sdlatud assays
1151 a Host mediated assay, microbial cells In aniasl hosts
Aniast in viva
lIST a Mouse spot test
WA * Sister cliromstld exchange, anil cells in viva
NVN a Mlcrorsjct.im test, mice in viva
CU a Chre ’s’—l aberrations, animsl bone asrrow ccl Is in viva
DLIl a Dosinant lethal test, mice
DIR a Dominant lethal test, rats
Ni.n In viva
SI_N a Sister chromstld exchange, hia.n l hocyt.s in viva
a Chr’ s sl aberrations, M n L hocytea In viva
Alternative testcodss (not Included In profiles)
RID a Binding (covalent) to DMA In vitro
B’ a BindIng (covalent) to DMA, aniast cells in viva
-------
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Pesticide Irdaced DMA and Its repsir in cultured
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Reversibte ir ibit1on of 011* synthesis in h.t.r ryo cells in culture:
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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-------
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