UnttMSttm
EiwirennwnttI Prottction
AgMicy
OffiMOf
P«rttcid«i ind Toxic
WMhington DC 20460
Sapt.mbw 1985
xvEPA
Guidance for the
Reregistration of
Pesticide Products
Containing Diflubenzuron
as the Active Ingredient
-------
CASE NUMBER
GUIDANCE FOR THE
REREGISTRATION OF KANUPACTURING-USE
AND CERTAIN END-USE PESTICIDE PRODUCTS
CONTAINING
DIFLUBENZURON
(108201)
CAS 35367-38-5
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20^60
September 1985
-------
TABLE OF CONTENT
Page
Introduction • • • • • • • • 1
I. Regulatory Position and Rationale
II. Requirement for Submission of Generic Data 57
iii. Requirement for Submission of Product_Specific
Data 60
I V. SubmiSsiOn of Revised Labeling 60
A. Label Contents . 61
B. Collateral Information 66
V. Instructions for SubmisSiOn 67
i.
-------
APPENDICES
Page
1 1—1 Guide to Bibliography . . . . . . . . . . . . . . . • 70
11—2 Bibliography 72
11—3 FIPR.A §3(c)(2)(B) Summary Sheet — EPA Form 8580—1 . . 87
II— Certification of Attempt to Enter Into an Agreement
with Other Registrants for Development of Data
EPA Form 8580—2. . . . . . . . . . . . . . 88
111—1 Product Specific Data Report (End—Use Products) . . 89
IV—1 ZO CFR 162.10 Labeling Requirements 91
IV—2 Table of Labeling Requirements 98
IV—3 Physical/Chemical Mazards Labeling Statement. . . . 101
IV— Storage and Disposal Instructions 102
ii
-------
INTRODUCTION
The Federal Insecticide, Fungicide 1 and Rodenticide Act
(FIFRA sec. 3(g)) directs A to reregister all pesticides as
expeditiously as possible.
To carry out this task, A has established the Regis-
tration Standards program, which will review a.].l pesticide
products containing active ingredients first registered before
January 1, 1977. Pesticides will be reviewed in use clusters
which have been ranked to give earliest review to pesticides
used on food and feed crops.
The Registration Standards program involves a thorough
review of the scientific data base underlying pesticide
registrations and an identification of essential but missing
studies which may not have been required when the product
was initially registered or studies that are now considered
insufficient. A’s reassessment results in the developcient
of a regulatory position, contained in a Registration Standard,
on each pesticide and its uses. The Agency may require the
registrant to modify product labels to provide additional
precautionary statements, restrict the use of the pesticide
to certified applicators, provide reentrT intervals, modify
uses or formulation types, specify certain packaging limitations,
or other requir nents to assure that proper use of the pesticide
will not result in adverse effects on the envirorment.
The scientific review, which Is not conta.ined in this
Guidance Package but is available upon request, concentrates
on the technical grade of the active ingredient and identifies
missing generic data. However, during the review of these
data we are also locking for potential hazards that may be
associated with the end use (formulated) products that contain
the active ingredient. If we have serious concerns, we will
address end use products as part of the Registration Standards
program ar will propose regulatory actions to the extent neces-
sary to protect the public.
f nas the authority der FIFRA sec. 3(c)(2)(B) to
require registrants to su data that will answer our
questio:is regarding the hazard that may result from the
intended se of a pesticide. Although sec. 3(c)(2)(B) provides
that all registrants are responsible for these data, the
Agency generally imposes generic data requir ierits only on t}
registrarts of the manufacturing use products (basic suppliers
1
-------
of the active ingredient) and other producers who do not
qualify for the forTnulator’ s exemption. *
A producer who wishes to qualify for the formulator’s
exemption may change his source of supply to a. registered
source, provided the source does not share ownership in
coffmon with the registrant’s firm. A registrant may do so
by submitting a new Confidential Statement of Formula, A
Form 8570—u, identifying the registered source of the active
ingredient, to the appropriate Product Manager within 90
days of receipt of this Guidance Document. The chart on the
following page shows what is generally required of those who
do and do not qualify for the fornni]- tor’ s exemption in the
Registration Standards program.
If you decide to request the Agency to cancel the regis-
tration of any of your products subject to the requirements
of this Guidance Document, please notify the Product Manager
named in the cover letter, within 90 days fran the receipt
of this document. If ‘ou decide to maintain your product
registration(s), you must provide the information described in
the following pages wIthin the tlmeframes outlined. A will
issue a notice of intent to cancel or suspend the registration
of any currently registered product whic ’ does not canply
with the requirements set forth in this Guidance Document.
You are reminded that FIThA sec. 6(a)(2) requires you to
8Ubm.tt factual information raising concerns of possible
unreasonable adverse effects of a pesticide. You should
notify the Agency of interim results of studies in progress
it those results show possible adverse effects.
‘The formulator’s exemption applies to a registrant of an
product if the source of his active irig ’edierit(s): (1) is a
registered product arid (2) is purchased fran a source which
does not have ownership in coi on with the registrant’ a
firm.
-------
W Tl iE
P DUCTS SUBJECT
R ISTRATION STANDARDS FR(XRAN —
MAINTAIN IST?ATION
I. Products That Do Not Qualify
Exemption
For The
be reregis—
A. Single Active Ingredient
products’
These products
tered. To obtain reregistratiOn,
labeling, packaging arid data
requirementS must be satisfied
in accordance with the Regis-
tration Standards Guidance
Document.
be
B. Multiple Active Ingredient
Products
These products will
reregistered at this time.
However, generic data required
to continue the registration of
the active ingredient under
review, as described in the
Registration Standards Guidance
D cuzr nt, will be required and
some labeling precautions may
also be required.
ii. Products That Do Qualify For Only when additional restriC—
The Formulator’s Exemption tions or labeling are needed to
protect man or the environment
will these products be subject
to the Re g1stratiOfl Standard
requirements. Affected products
will be dealt with in a variety
of ways, including but not
limited tO the Label Improvement
Program and special intent
to cancel notices.
U id use products of registrants who also produce ufactur’ing —
use product will not be required to be reregistered provided that
registrant fulfills the requirements specified in the Guidance
Document for manufacturing use product(s). Such end use products
will be subject to the labeling changes required for products in “II”
above. If there are no manufacturing use products registered by any
company end use products will be required to be reregistered.
NOTE: If all registrants in “I” above fail to meet the requirements in
I—A arid B above, then the registrants in “II” lose their right to
qualify for the formulator’s exemption arid become subject to the
requirements in I-A and B.
3
-------
II. R ULATORY SITION AND RATIONALE
A. Introduction
This chapter contains the Agency’s regulatory position
arid rationale on products contain.trig the pesticide diflubenzurOn
as a sole active ingredient. The Agency bases its position and
rationale on a consideration of all uses of diflubenzuron appearing
on pesticide products registered under sections 3 arid 2L (c) of
as well as on products authorized for distribution in
intrastate ccmnerce under 1 O CFR 162.17. The Agency has reviewed
the laiown ch nical, eriv1ror ental, arid toxicological characteristics
of this pesticide and its established t±erances for residues in
or on food arid feed ca odities. Fr these considerations the
Agency sets forth the data and labeling requirements that must be
met by registrants arid applicants for registration of diflubenzu.rcn
manu.facturirig—use products (?‘ s) in order for their products to be
registered or reregistered under this Standard. Unique labeling
requirements and certain data needs for end-use products (es)
containing dif].ubenzuron are also established by this Standard.
Only those data and labeling requirements for current
and future substantially similar ? s and s are addressed here.
Applications to register products that differ appreciably fr i
those described in this Standard may be subject to additional
data and/or labeling requir ents.
14
-------
B. Description of Ch .ical
Diflubenzuron is the American National Standards
Institute (ANSI), British Standards Institution (ESI), European
International Organization for Standardization (E-ISO), and French
Organization Internationale de Norma.lization (F—ISO) approved
cainion name for an insecticide menufactured solely by Duphar, E.V.
(Holland).
The ch ica1 name of diflubenzuron is N- [ [ (14-cbj.orophenyl)
amino carbony]. ]—2 , 6—difluorobenzamide. Other names include
Dimilin, Vigilante, di.fluron, deflubezizon, diflubenuron, Largon,
EU 112307, OMS 18014, PDD 60 140—I, PH 60—140, Th 60140, 60140, and
1— ( 14—chiorophenyl )—3— (2, 6—d.tf 1uorobenzo T) urea. Other identifying
characteristics and codes are:
npirica1 Formula: Cl 1 4H lF2N2O2
Molecular Weight: 310.7
4T Registry No.: 29 0514
Shaugbnessy No.: 108201
Ch ica.1 Abstracts No.: 35367—38—5
Technical diflubenzurofl is a white, crystalline solid
with rio odor and a melting point between 210 and 230 °C. The
Density/Specific Gravity is 1.2089 g/cm 3 . Diflubenzuron is
soluble in water and most organic solvents. It has an octanol/water
partition coefficient of about 5000.
5
-------
Dlflubenzuron is stable at low pH in sterile water
but is less stable at higher pH leve)s, particularly at higher
temperatures. It is stable in ultraviolet light.
Registered diflubenzurOfl technical (Tech) and formu-
lation intermediate (P1) products include the following:
Uniroyal Chemical Corporation, 95 percent Tech (EPA Reg No
130—366); T H Agriculture and Nutrition Company, 90 percent
F l (EPA Reg No 1469116—245); and Duphar,B.V. 95 percent Tech
(EPA Reg No 37100—10) and 90 percent F l (EPA Reg No 37100-9).
EPA Registration Numbers are presented parenthetically. The
90 Percent Fl registered by T H Agriculture and Nutrition
Company and the 95 percent TechTegistered by Uniroyal Chemical
Corp. are produced in Holland by Duphar B.V. and are identical
to the 90 percent Fl and 95 percent Tech products registered
by Duphar B.V. Diflubenzuron is formulated into 25 percent
wettable powder for use as a foliar spray, incorporation
into the growIng medium for mushrooms or field formulation
into granules for mosquitoe control. Uniroyal Chemical Corp.
and T H Agriculture and Nutrition Co. have assigned rights
to all submitted data to Duphar B V.
Diflubenzurofl disrupts the normal moulting of insects
and other invertebrates by interfering with the deposition of
chitin. DlflubenzurOfl primarily affects immature individuals
at the time of the growth process when a new exoskeleton is
formed and the old one shed.
6
-------
C. Regulatory Position and Rationale
Based on a review and evaluation of all available data
and other relevant information on diflubenzuron, the Agency has
made the following determinations:
1. All products containing diflubenzur’on as a sole
active ingredient may continue to be registered for sale, distri-
bution, reformulation, arid use subject to the terms and conditions
specified in this Guidance Doci.m ent. Registrants must provide
or agree to develop, within the required time frame, additional
data as specified i n tables A and B in order to maintain existing
registrations or to permit new registrations.
Rationale : Under FIFRA, the Agency normally does not
cancel or withhold registration simply because data are missing
or inadequate (For example see sections 3(c)(2)(B) and 3(c)(7) of
I 1ENA). Issuance of this Standard provides a mechanism for identi-
fying data needs and providing time frames for their production.
It enables the Agency to modify labels during the period in
which required data are developed. These data will be reviewed
and evaluated after they are received and the Agency will determine
at that time whether they will a.ffect the registration(s) of
diflubenzuron.
2. Additional data are needed to determine if the
final product might contain contaminants of toxicological
7
-------
si iifica.nce. The following additiora]. process chem.tstry data
are required:
Details of the manufacturing process including
the relative amounts of beginning materials, a
description of the equipment used to produce the
product, reaction conditions, the duration of
each step of the process, purification
procedures, and quality control measures for
the 95% T and 90% Fl formulations.
The name arid address of t manufacturer,
producer, or supplier of each beginning material
arid a copy of all available technical specifications,
data sheets, arid other doc ents by which the
manufacturer, producer, or supplier of the
begl.nning material describes its composition or
properties.
Quantitative data on all ingredients const1tuttn ,
0.1% or more of the final product.
8
-------
A discussion of each impurity believed to be
present at >0.1% based on Iciowledge of the beginning
materials, all possible chemical reactions and any
contamination.
Certification of ingredient limits for the
technical and formulation intermediate products.
Rationale : Process chemistry data are
needed to determine if contaminants are present
which are of toxicological si iif1cance.
3. On the basis of the existing data base, it
dose not appear that diflubenzu.ron is an oncogeri.
Rationale : In 1979, the Agency concluded
a Rebuttable Pres znption Against Registration (RPAR)
review of dif].ubenzuron and found that dz a were
insufficient to determine its oncogenic otentia.1.
Lifetime feeding studies of rats arid m c& received
and reviewed since that time demonstrate chat
diflubenzuron did not cause an increane in the
incidence of t nors at any level. Th iighest
dose tested was 10,000 p (500 mgjkg bwt/day).
9
-------
4. Althoug i the Agency is unable to canplete a tolerance
reassessment because of certain residue chemistry arid toxicology
data gaps, the Agency concludes that no change in present
tolerances is indicated at th.is time.
ationale : A No Observed Effect Level (NOa) of 140 ppm
( g/kg) was demonstrated in the rat. The resulting Provisional
Acceptable Daily Intake (PADI) is equal to 0.02 mg/kg body
weight/day utilizing a 100—fold safety factor. The PADI is the
maximum amount of residue which the Agency will permit on food
crops until all the required toxicology studies have been
su n.ttted and an Acceptable Daily Intake is established. The
existing tolerances (including those in meat and milk) caiiprise
2.9 percent of the PADI. Since on the basis of existing data it
was determined that diflubenzurofl was not an oncogen the Agency
does not consider it necessary to utilize a safety factor greater
than 100 in estimating a PADI at this time. However, the Agency
intends to re—evaluate this position upon ca pletion of the
review of the required 1-year dog feeding stud ’ s’hiCh was sub-
mitted to the Agency on June 19, 1985, arid is currently under
review. If new information defining - an unsu. pe ted adverse
effect beccnes available, the Agency would c n ider recalculating
the Acceptable Daily Intake (ADI). The Ager y M.ll consider
all future tolerance proposals for diflubenZLron on a case—by-
case basis pending receipt and review of the data needed to
correct the deficiencies noted in the tables.
10
-------
These NOR. and PADI calculations were based on the levels needed
to discern methe og1obinema and su1 oglobinernia impainnents of the
oxygen transport capability of blood. The data used to calculate the
NO were su .ttted following a special review considering toxicological
concerns expressed in the March 26, 1979 Diflubenzuron Decision Document.
5. All EP’s containing diflubenzuron to be used on forests
(including Christcas tree plantations & nurseries), cotton, soybeans
and irrigated pasture shall continue tobe classified for restricted
use and shall contain label warnings about possible hazards to aquatic
invertebrates.
ationale : Existing data showing high acute toxicity of the
active ingredient to aquatic invertebrate ani.ma.ls juztlSy the continued
classification of difluben.zuron as a restricted use pesticiae. Potential
hazards to aquatic invertebrate animals caL ed by dri.ft fran aerial
and ground applications warrant label wa.r ings until risks are further
defined. Additional data are bei ur d to better define hazards
to non-target organisms to determine whe the: additional regulatory
action is required.
11
-------
6. Concerns need to be resolved regarding the potential
for diflubenzuron to contaminate groundwater.
Rationale : In 198k the Agency initiated a special
ground water data call-in for a number of chemicals, including
diflubenzuron, which may have a potential to contaminate ground-
water based on such factors as chemical structure 1 solubility,
and use patterns. To characterize the potential for diflubenzuron
to enter ground waters, the Agency determined that additional data
were needed. These data are among the basic requirements in the
area of environmental fate and product chemistry for chemicals
used outdoors. In response to the- call—in notice, data were
submitted in May 1985 and are currently under review. Followirlb
review of’ those data, the Agency will determine whether additional
regulatory requirements to address any groundwater concerns arise
from those data.
7. Development of additional data on effects on
aquatic invertebrates was on of the issues in the special
review conducted in 1979.
Rationale : Data sibnitted subsequent to the issuance of
the March 26, 1979 Decision Document are sufficient to justify
continued registration until additional data specified in the
tables are generated.
12
-------
8. Concerns need to be resolved regarding potential
field accumulation resulting in residues in rotational crops.
Rational : Additional data are required to determine
the amount of diflubenzuron residues in crops planted following
the harvest of treated crops.
D. Criteria for Registration Under This Standard
To conform to this Standard, products must contain
diflubenzuron as the sole active ingredient, bear required
labeling, and conform to the product composition, acute toxicity
limits, and use pattern requirements listed in Section E of this
document.
The application for registration or reregistration o ’
MPs subject to this Standard must comply with all terms and
conditions describei in it, including submission of an up-to-date
Confidential State.n nt of Formula, submission of r Ised labeling,
commitment to fil’ data gaps on the schedule specified by the
Agency and, when applicable, offer to pay compensation to the
extent required by sections 3(c)(l)(D) and 3(c)(2)(D) of FIFRA,
as amended, 7 U.S.C. 136(c)(l)(D) and 136(c)(2)(D). Any registrant
of an EP which qualifies for the Formulator’s Exemption must submit
five (5) copies of draft labeling incorporating the unique label
13
-------
statements identified in Section F.
E. Acceptable Ranges and Limits
Product Composition Standard
To conform to this Standard, MPs must contain
diflubenzurofl as the sole active ingredient. Each MP formulation
proposed for registration must be fully described with an appropri-
ate certification of limits, stating maximum and minimum amounts
of the active and intentionallyadded inert ingredients which
will be present in products.
Acute Toxicity Limits
The Agency will consider registration of technical
grade and MPs containing diflubenzuron, provided that the product
labeling bears appropriate precautionary statements for the
acute xicity category in which each product is placed.
Use Patterns
To conform to this Standard, MPs containing diflubenzuron
may be labeled for formulation into EPs only for the commodities
listed below. The attached index entry lists all registered
114
-------
uses as well as approved maximum application rates and frequencies.
Terrestrial 1 non—domestic, food uses on:
cotton, irrigated pasture, soybeans.
Greenhouse food crop: mushrooms.
Terrestrial, non—food uses on: Ornamental
and/or Shade Trees (nursery stock).
Forestry Uses on : Forests including Christmas
Tree Plantations
F. Required Labeling
All manufacturing-use and end-use diflubenzurorl products
must bear appropriate labeling as specified in 4 O CFR 162.10.
The guidance package for this Standard contains information on
label r quiremeflt8.
Ingredient Statement
The ingredient statement for MPs and EPs must list
the active ingredient as:
diflubenzuron:
N_ [ [ (14_Chloropheflyl)amlflo]CarbOflYl]2 ,6—diflurobenzamide
15
-------
Use Pattern Statement
All manufacturing-use diflubenzuron product labels
must state that the products are intended for
formulation into EPs for the aforementioned use
patterns. Labeling must specify sites. A limiting
factor will be data that support these use patterns.
No use may be included on the label where the
registrant fails to agree to comply with the data
requirements in either table A or table B for that
use pattern. —
Precautionary Statements
Statements for Manufacturing-Use Products
Labels for manufacturing—use diflubenzurori products
must bear statements rerlecting t e compound’s toxicity
to aquatic invertebrates. The following revised
environmental hazard statement must appear on all MP
labels:
This pesticide is extreml toxic to crab, shrimp.
16
-------
and other aquatic invertebrates. Do not discharge
effluent containing this product into lakes, streams.,
ponds, estuaries, oceans, or public waters
unless this product is specifically identified
and addressed in an NPDES permit. Do not
discharge effluent containing this product to
sewer systems without previousl ., notifying the
sewa e treatment plant authority. For guidance
contact your State water board or Regional Office
of the EPA. —
Statements for End—Use Products
1. All EP’s to be used on t’orests, cotton,
soybeans, and irrigated pasture must bear the
restricted—use statement:
RESTRICTED USE PESTICIDE
Due to toxicity to aquatic invertebrate animals
For retail sale to and use only by Certified
Applicators or persons under their irect
17
-------
supervision, and only for those uses covered
by the Certified Applicator’s certification.
The following statements must also be included on
all labels for outdoor use products:
a. Non—forest Uses
This pesticide is ex - emely toxic to crab, shrimp,
and other aquatic invertebrates. Do riot apply directly
to water or wetlands. Drift or runoff from treated
areas may be hazardous to aquatic cr anismS in
neighboring areas. Do not contaminate water by c1eantn
of equipment or disposal of wastes.
b. Forest Uses
This pesticide is extremely toxic to crab, shrimp, and
other aquatic invertebrates. Do riot apply directly
to water or wetlands, except under the forest canopy.
Drift or runoff’ from treated areas may be hazarnous to
aquatic organisms in nei6hborin areas. Do not contaminate
water by c1eanin of equipment or disposal ot wastes.
18
-------
2. In the absence of adequate crop rotation data,
the crop rotation restriction below must be placed on aJ.l end
use products which y be used in a situation where rotation
with crops used for food or feed that are not included on t
dl.flubenzuron regis trat ion may occur:
Restrictions on Rotational Crops
Uj) 0 not plant food arid feed crops in
diflubenzurori treated soils,within six
nths following last application, unless
diflubenzuron is authorized for use on
those crops.”
G. Tolerance Reassessment &m ary
The established tolerances I or diflubenzurori are
published in 40 CFR 180.377. A s .minary of these tolerances
is presented ir table I.
Although the Agency is unable to complete a tolerance
reassessment because of certain residue ch istry and toxicology
data gaps, the Agency concludes that rio change in present
19
-------
tolerances is indicated at this time for the following corrinodities:
cottonseed, pasture grass, soybeans, soybean hulls, soybean
soapstock, milk, eggs and the meat) fat and meat by—products of
cattle, goats, hogs, horses, sheep and poultry. However, additional
data are required to support the existing tolerance for residues
in or on mushrocins.
The available plant metabolism data are adequate provided
application is by foliar spray. The data indicate that following
such trea nt no translocation of residues to untreated plant
parts occurs.
The available data do not, however, adequately describe
the nature of the residue following direct application to soil.
The available data indicate that residues are taken up frcm soil
into the roots arid above ground portions of plants and metabolism
of the parent occurs, to satie degree, either in the soil or in
the plant itself.
Since mushrocn s are treated via the soil (cc ost) and,
as fungi, display metabolic behavior which differs frwi that
of higher plants, additional data are required for c nplete
elucidation of the nature of the residue in mushroans to support
the established tolerance in rnushroans.
20
-------
The residues found following foliar applications have
been shown to consist almost entirely of the parent ccinpound.
Following soil treatments, p—chlorophenylurea was found to be a
major metabolite in higher plants and 2,6—difluorobenzoric acid
was found to be the maj or metabolite in rnu.shroans following
treatment of mushroom beds. Para-chlorophenylurea was found in
mushrooms at levels approximating those of diflubenzuron per Se.
The nature of the residue in White Leghorn chickens is
adequately understood. Metabolism studies in which tissue and
egg residues are identified are required for breeds other
than White Leghorns.
Additional data are needed to ascertain the nature of
the residue in ruminants. Characterization of the residue in
cattle liver and kidney is required. Studies on the nature of
the residues in milk at different feeding levels are required.
I! metabolism in ruminants differ? fl that in poultry,
additional data regarding the metabolism of diflubenzurcn in
swine will be required.
In conjunction with the required metabolism arid residue
studies, data are required reflecting the frozen storage stability
21
-------
of diflubenzurofl in representative animal coriTnodities fortified
at levels of 0.05 p at intervals up o 15 monthS.
The PADI of diflubenZUrofl is 0.02 rng/k /day. This is
based on a NOEJ of L 0 ppm (2 mg/kg/day) on met- and sulphe no—
globin formation in rats in a study conducted by B. Hunter et al. ,
1975. A 100—fold safety factor was utilized.
Existing tolerances ccinprise 2.9 percent of the PADI.
An ADI will be calculated after su1ini siOfl of required toxicity
data, including a 1-year dog feeding study, and any other data
which may show adverse effects.
22
-------
Table I
Cani odity
Si. ary of Present Tolerances
Tolerances (ppm)
United States Canada Mexico International
(Codex)
Cattle, fat 0.05 — 0.05
Cattle, mbyp 0.05 — 0.05
Cattle, meat 0.05 — 0.05
Cottonseed 0.2 — 0.2
Eggs 0.05 — 0.05
Goats, fat 0.05 — 0.05
Goats, mbyp 0.05 — 0.05
Goats, meat 0.05 — 0.05
Hogs, fat 0.05 — 0.05
Hogs, mbyp 0.05 —— 0.05
Hogs, meat 0.05 — 0.05
Horses, fat 0.05 — 0.05
Horses, mbyp 0.05 — 0.05
Horses, meat 0.05 — 0.05
Milk 0.05 — 0.05
Mu.thro nz 0.2 -— 0.].
Pasture grass 1.0 0.1 —
Poultry, fat 0.05 — 0.05
Poultry, mbyp 0.05 — 0.05
Poultry, meat 0.05 — 0.05
Sheep, fat 0.05 0.05
Sheep, rnbyp 0.05 0.05
Sheep, meat 0.05 0.05
Soybeans 0.05 0.1
Soybean soapstock 0.1 -—
Soybean hulls 0.5 ——
23
-------
EPA—Compendium of Acceptable Uses
c lOB2Ol DIFLU ENZURON*
TYPE PESTICIDE : Insect growth regulator
FORMUI..AT IONS :
Tech (90%, 95%)
wp (25%)
GENERAL WARNINGS AND LIMITATIONS : Hone.
Agricultural Crop Tolerances (other than those listed in the text) :
1.0 ppm Grass, pasture
Livestock Tolerances :
0.05 ppm (fat, meat, and meat byproducts of cattle, goats, hogs, horses,
poultry, and sheep)
0.05 ppm (eggs)
0.05 ppm (milk)
*Djmjl in
N_ [ ((4_chlorophenyl)amino]carboflYl)2,6dif luor obeflzamide
l—(4—chlorophenyl))( 2 1 6 difluorobenzoyl.)urea
Issued: 1—31—84 1 1I1082011
Provisional Update: 7—25—85
-------
EPA Compendium of Acceptable Uses
DIFLUBENZURON
Site and Pest Dosages and Tolerance, Use, Linitations
Formulation(s)
TERRESTRLAL FOOD CROP
General Warnings and Limitations : Do not plant any food or feed crop in
diflubenzuron treated soils, within six months following last application,
other than those with registered diflubenzuron uses. Diflubenzuron is ex-
tremely toxic to crab 1 shrimp, and other aquatic invertebrates. Do not
apply directly to water or wetlands. Drift or runoff from treated areas
may be hazardous to aquatic organisms in neighboring areas. Do not con-
taminate water by cleaning of equipment or disposal of wastes.
/28007AA Cotton RESTRICTED USE PATTERN
0.2 ppm (cottonseed)
Do not apply after boils begin to
open through 1 ounce per acre for
foliar application. Do not make
more than 6 applications or apply
more than 6 ounces per acre per crop
season.
Do not graze or feed treated cotton
foliage.
LNASM B Boll weevil (eggs) Up to 1 oz/ oliar application. Apply at the
:NAsAHc Boil weevil 2—4 qt oil/A pinhead square stage of cotton
(larvae) (25Z WP) growth when over’wintering weevils
enter fields. Apply in 2 to 3 gal-
lons of water per acre by aircraft
or in 5 to 30 gallons of water per
acre by ground equipment. Repeat
at 5 to 7 day intervals. Following
initial contact of pest with diflu—
benzuron, 7 to 10 days are required
before infertile eggs are laid.
Mixing with oils:
Emulsifiable paraffinic crop oil :
Use 2 to 4 quarts per acre. To
avo c forming an invert emulsion,
use a minimum of 2 parts of water
for each part of oil.
VeLetable oil, such as once sieved
cc’cc’-rnseed oil: Use 2 quarts per
a.re and appLy without water.
?ld .fy spray equipment to provide
droilets with a diameter of 150 to
00 microns.
Issued: 1—31—84 1 1 1l0820 12
25
-------
EPA Compendium of Acceptabl.e Uses
DIFLUBENZURON
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
GREENHOUSE FOOD CROP
( Agricultural Crops)
General Warnings and Limitations : Refer to TERRESTRIAL FOOD CROP.
0.2 ppm
Compost treatment through 2.5
pounds per 2,500 square feet.
Casing soil treatment through 0.53
pounds per 2,500 square feet.
10 BFMC
Darkwinged fungus
gnats (larvae)
1.5—2.5 lb/
2,500 sq.ft
Compost
(25% WP)
Mushroom Compost Treatment :
Apply at time of spawning. Thor-
oughly incorporate into the compost.
Spawning machines may be used for
incorporation. This is equivalent
to 30 to 50 ppm when the compost
wet weight is 40 pounds per cubic
foot.
Issued: 1—31—84
0.527 lb/
2,500 sq.ft
Casing soil
(25% wP)
Mushroom Casing Soil Treatment :
Apply at time of casing. E .ther
thoroughly incorporate into the
casing or in sufficient water to
obtain a thorough drench. This is
equivalent to 30 ppm when the
weight of the casing soil is 8.375
tons per 2,500 square feet.
111—108201—4
/ 16 003AA
Mushrooms
26
-------
EPA Compendium of Acceptable Uses
D LFLU3ENZURON
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
Cotton (continued)
ITAYAHC
Cotton leafperfo—
rator (larvae)
0.5— I oz/A
(25 WP)
Foliar application. Apply when
larvae appear on leaves and foliar
feeding becomes evident, normally
at the third or fourth instar stage.
Apply in 1 to 5 gallons of water
per acre by aircraft or in 5 to 30
gallons of water per acre by ground
equipment. Repeat at 5 to 7 day
intervals as needed.
RESTRICTED USE PATTERN
0.05 ppm (soybeans)
0.5 ppm (soybean hulls)
0.1 ppm (soybean soap stock)
21 day preharvest interval through
1 ounce per acre for foliar appli-
cation. Do not make more than 2
applications per growing season.
Do not cut for hay or allow grazing
of treated areas.
Green cloverworm
(larvae)
Velvecbean cater-
pillar (larvae)
Issued: 1—31—84
Foliar application. Apply when
larvae are small (first to third
instar). Repeat when damaging num-
bers reappear. Consult Cooperative
Extension Service regarding infes-
tation levels requiring treatment.
Apply in I to 3 gallons of water
per acre by aircraft or in 9 to 35
gallons of water per acre by ground
equipment. Labeling claims 3 to 5
days between application and reduc-
tion of populations.
111—108201—3
/28023AA Soybeans
LIBCCCC
LTB CAIC
0.5—I oz/A
(25% WP)
27
-------
EPA Compendium of Acceptable Uses
D IFLUBENZURON
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
TERRESTRIAL NON—FOOD CROP
( Ornamental Plants and Forest Trees)
General Warnings and Limitations : Diflubenzuron is extremely toxic to
aquatic invertebrates. Do not apply directly to water or wetlands, ex-
cept under the forest canopy. Drift or runoff from treated areas may
be hazardous to aquatic organisms in neighboring areas. Do not contam-
inate water by cleaning of equipment or disposal of wastes.
‘35000DA Ornamental and/or Shade Trees RESTRICTED USE PATTERN
‘30000AA ( nursery stock )
.TAXAIC Gypsy moth (larvae) 0.25—0.5 oz/A Use limited to quarantine programs
(25Z UP) involving the movement of nursery
stock from infested to non—infested
areas.
Foliar application. Make 2 appli-
cations at 7 to 14 day Lntervals.
TBUDEC Nantucket pine tip 1. az/A Foliar application. Apply to early
moth (larvae) (25Z UP) Lnstar stages of development at
second generation egg hatch. Apply
in 0.5 to 2 gallons of water per
acre by aircraft or in 10 to 200
gallons of water per acre by ground
equipment.
FORESTRY
General Warnings and Limitations : Diflubenzuron is extremely toxic to
crab, shrimp, and other aquatic invertebrates. Do not apply directly to
water or wetlands, except under the forest canopy. Drift or runoff from
treated areas may bc harzardous to aquatic organisms in neighbori.rtg areas.
0005A.A Christmas Tree Pi n — RESTRICTED USE PATTERN
tations
TBUDEC Nantucket pin tip 1 oz/A Foliar application. Apply to early
moth (larvae) (25Z WP) Lnstar stages of development at
second generation egg hatch. Apply
in 0.5 to 2 gallons of water per
acre by aircraft or in 10 to 200
gallons of water per acre by ground
equipment.
Issued: 1—31—84 t 1 11082015
28
-------
EPA Compendium of Acceptable Uses
DIYLUBENZURON
/30000A.A Forest Trees, Forest Lands
ITAXAEC Douglas-fir tussock 1. oz/A
moth (larvae) (25% WP)
Forest tent cater-
pillar (eggs)
Forest tent cater-
pillar (larvae)
RESTRICTED USE PAITERN
Fol .iar application. Apply after
egg hatch when larvae are in first
and second instar stages,
approximately 5 days after full
hatch. Apply in 0.5 to 2 gallons
of water per acre by aircraft or in
10 to 200 gallons of water per acre
by ground equipment.
Foliar application. Apply in the
early instar stages of development
and or before foliage is expanded.
Apply in 0.5 to 2 gallons of water
per acre by aircraft or in 10 to
200 gallons of water per acre by
ground equipment.
Claims for control of forest tent
caterpillar eggs are limited to
— suppression of populations.
ITAXAIC
Gypsy moth (larvae)
0.25l os/A
(25% wP)
Foliar application. Apply prior to
full leaf expansion when larvae are
in the first through third instar.
Apply in 0.5 to 2.5 galirms of
water per acre by aircraft or in
1.5 to 10 gallons of water per acre
by ground equipment (mist blower).
Do not make more than 1 appLication
per year.
0.25—0.5 oz/A Use limited to United States Depart—
(25% WP) ment of Agriculture, Animal Plant
Health and Inspection Service, Plant
Protection and Quarantine personnel
and state cooperators involved in
quarantine programs.
Foliar application. Apply for use
in eradication of isolated infesta-
tions. Make 2 applications at 7 to
14 day intervals.
0.25—0.5 02/A
(25Z WP)
Use limited to quarantine programs
involving the movement of nursery
stock from infested to non—infested
areas.
Foliar application. Make 2 appli-
cations at 7 to 14 day intervals.
Site and Pest
Dosages and Tolerance, Use, Limitations
Forniu 1 at ion ( a )
ITAUAGB
ITAUAGC
1 os/A
(25% WP)
Issued: 1—31—84
llI—l08201
29
-------
EPA Compendium of Acceptable Uses
DIFLUBENZURON
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Forest Trees, Forest Lands (continued)
ITBUDEC Nantucket pine tip I oz/A Foliar application. Apply to early
moth (larvae) (25Z WP) macar stages of development at
second generation egg hatch. Apply
in 0.5 to 2 gallons of water per
acre by aircraft or in 10 to 200
gallons of water per acre by ground
equipment.
AERIAL, MOTHPROOFING AND TANK MIX APPLICATIONS
9001500 Aerial Aplication
AAAA
Refer to
TERRESTRIAL FOOD CROPS
Cotton, Soybeans
GREENHOUSE FOOD CROP
Mushrooms
TERRESTRIAL NON-FOOD CROP
Ornamentals and/or Shade Trees
(nursery stock)
FORESTRY
Christmas Tree Plantations, Forest
Trees, Forest Lands
Issued: 1—31—84 1I 1 1082017
30
-------
EPA Compendium of Acceptable Uses
DIPLUBENZUROt
Listing of Registered Pesticide Products by Formulation
&090.0001. 90% technical chemical
diflubenzuron (108201)
037100—00009 046946—00245
095.0001 95% technical chemical
diflubenzuron (108201)
000400—00366 037100—00010
&025.0006 25% wettable powder
d .f1ubenzurort (108201)
037100—00007 037100—00008 037100—00016 046946—00060
046946—00238 046946—00243
Issued: 1—31—84 III— 10820 1-8
31
-------
EPA Compendium of Acceptable Uses
DIFLUBENZIJRON
Appendix B
Listing by Site/Pest and Site/Formulation/Registration Number
TERRESTRIAL FOOD CROPS
/28007AA Cotton
LNASAIIB Boll weevil (eggs)
LNASAHC Boll weevil (larvae)
LTAYA 1C Cotton leafperforator (larvae)
(25% WP)
037100—00008 046946—00238
/28023AA Soybeans
IT BCCCC Green cloverworm (larvae)
LTBCATC Velvetbean caterpillar (larvae)
(25% wP)
046946—00243
GREENHOUSE FOOD CROP
( Agricultural Craps )
/ 16003AA Mushrooms
IOBFAAC Darkwiaged fungus gnats (larvae)
(25% WP)
037100—00016
TERRESTRIAL NON—FOOD CROP
( Ornamental Plants arid Forest Trees )
/35000DA Ornamental and/or Shade Trees (nursery stock )
ITAXAIC Gypsy moth (larvae)
ITBUDEC Nantucket pine tip moth (larvae)
(25% WP)
037100—00007 046946—00060
FORESTRY
/3 0000AA Christmas Tree Plantations
ITBUDEC Nantucket pine tip moth (larvae)
(252 wE
037100—00007
Issued: 1—31—84 111—108201-9
-------
158.120 Product ChEmistry
Product Identity :
61—i - Product Identity and Disclosure
of’ Ingredients
61—2 — Description of Beginning Materials
and Marn. factu ring Process
61—3 - Discussion of Fonnation of
Impurities
Analysis and Certification of Product
Ingredients
62—i — Preliminary Analysis
Physical and Chemical Characteristics
63-2 - Color
63-3 - Physical State
63-’s -
63-5 -
63-6 -
Odor
Melting Point
Boiling Point
TABLE A
QFJ lEi1IC DATA RE tJIRh} EWFS FOR DIFUJBEiIZURON
Data Must
Be
;uideline Citation arvJ
Peat
Guldeithes
Are Data
Footnote
Submitted
Within
lame
of’
Test
Substance
Status
Required
Yes
No
Number
Time Frames Listed
Below 1/
‘IOAI
¶IOAI
¶IUAI
IDIA I
IDA !
¶IOAI
¶1DAI
¶113A 1
¶IUAI
H
H
H
CR
H
R
H
H
R
33
[ ii
Ii]
(Ti]
[ 1]
[ ii
[ J
(Ti]
]
1 i I
LI
(Ti
(Ti
[ Ti
1
[ TI
liii
6
6
6
12
6
6
6
6
Months
Months
Months
Months
Months
Months
Months
Months
-------
TABLE A
GEN UC DATA RE JIRi 34EiFPS F R DIPUJBE Z1JF N
Data must Be
Guideline Citation arwJ
Teat
Guidelines
Are Data
Footnote
Submitted Within
Name
of
Teat
Substance
Status
Required
Yes No
Number
Time Frames Listed
Below .1/
§158.120 Product Chemistry (Continued)
Physical and Chemical Characteristics
(Continued)
63—1 — Density, Bulk Density, or ¶ AI H 1] ____________ 6 Months
Specific Gravity
63-8 - Solubility TOAI or PAl H [ ] ____________ 6 Months
63-9 — Vapor Pressure PAl ft (T I CI ____________ 6 Months
63-10 — Dissociation constant PAT H [ ] [ •J ___________ 6 Months
63-11 — Octanol/water partition PAT H [ ii Ii ____________ 6 Months
coefficient
63-12 — pH ¶IUAI H Ii ] 1] ____________ 6 Months
63-13 — Stability ¶ AI H 1 I [ 1 ____________ 6 Months
Other Requirements :
6’i- 1 — Submittal. of samples TUAI, PAl CR LI Ii] ___________
qoAI=Technicai Grade of the Active Ingredient; PAI= Pure Acti;e Ingredient;R= Required; CR Conditionally Required
1/ Data must be submttted within the indicated time frame, based on the date stamped on the front of this document.
3,’
-------
TABLE A
0ENE IC DATA REL 1JUU?MENTS 10R DIFIJJBE 4ZURON
To Satisfy This
Be SuI:mltted Under
Requirement? (Yes.
Bibliographic
FIFRA 3(c)(2)(B)?
ita
Requirements
1/
Ccinposition
No, or Partially)
Citation
Time Frames For Data
Submission 2/
158.125 Residue Chemistry Data Requirements
171-2 - Chemical Identity ¶IUAI Yea No
171-3 - Directions for Use Yea No
171-11 - Nature of Residue
— Plants PAIR.A Partially 00038268, 00099683 Yea 3 ! 18 Months
00099767, 00099778 —
000997911, 00099807
00099811’l, 00099807
I 00099881, QSO1IIII -00l
— Livestock PAIRA and Plant Partially 000110159, 000611922 Yes’l/ 18 Months
Metabolitea 00070185, ooo oi86
171 1I — Residue Analytical Method
— Plant residues ‘IUAI and Metabolites No 3 ! 00070181, 00070183 Yea 3 ! 15 Months
— 000701811, 00070700 —
00071822. 00071823
00099683, 000996811
00099686, 0009977’l
00099779, 001091160
— Animal residues IOAI and Metabolitea No 11 ! 00029737, 000297112 yea’l/ 13 Months
— o0o110767 , 000110770 —
00070181, 00070187
00070700, 00071822
00071823, 0S0111’i—002
0S01 1 1’I-003
35
-------
171-11 — Magnitude of the Residue
- Legume Vegetables Group
o Soybeans
— Citrus Fruits Group
— Pczne Fruits Group
— Grass Forage, Fodder,
and Hay Group
— Miscellaneous Ccgmiodltles
o Cottonseed
o Mushroans
— Meat/milk/poultry/eggS
TABLE A
(I Ei1IC DATA REL LJIREMFHI’3 FOR DI ? BF21ZtJR( l
Does EPA Have a
To Satisfy This
Requirement? (Yes
No, or Partially)
Yea
No?!
No 8 !
Yes?!
Yea 8 !
000281135, 0010911611 Yes 9 !
Be Submitted Under
ata
Requirements
1/
Ccxnpoa ltion
BibliographIc
Citation
FIFRA §
Time Frames For Data
Submiss Ion 2/
TEP Partially 6 !
TEP
TEP
TEE ’
TEE’
2 1 months
0S01 1i1 1—0011, GSO1IIII—005
03011111 -00 1 1, OSO1 IIII—005
yes 6 /
No
‘FEE’ Yea
TEP Partially ’ 0 !
¶ AI or YesH/
Plant Metabolitea
00038272, 000996911
001091160, 0301 1111-001
030111 1 1—011
00029737, 00029739
000297111, 000297112
00060385, 00070185
00070186
No
Ye a l O !
No t l /
36
-------
TABLE A
ai ut ic DATA REL (JIREMEWPS i on DIPIIJBENZURI4
§158.125 Residue Chemistry — Continued
1/ Composition: ‘ITIAI = Technic ’ l grade of the active Ingredient; PAIRA Pure active ingredient, radiolabeled;
TEP = Typical end—use product EP = End—use product.
2/ Data must be sutinitted wIthir the indicated time frames, based on the date stamped on the front or this document.
3/ The nature of the residue in muahrocina has not been adequately described. To support the registered use on
mushrooms data reflecting the distribution and metabolism of diflubenzuron (double l 1 1c_ring labeled) in mushrooms,
Agaricus biaporus , following treatment of mushroom growing media at 0.1 lb al/l00 square feet must be subnitted.
On receipt 01’ data requested in Nature of the Residue in Plants, the conclusions regarding acceptability of
methods of data collection and enforcement may change.
V Metabolism studies utilizing ruminants are required. Animals must be dosed for 3 days with double ring—labeled
[ l lC]djfluben uron at a concentration in the total diet whieh will result in sufficient residue in the cattle
liver, kidney, and milk for characterization. Animals must be sacrificed within 211 hours of the final dose (milk
must be collected twice daily). If metabolism in ruminants differs from that in poultry, additional data regarding
the metabolism of dlflubenzuron in swine will be required. Further information is needed on the toxicological
significance of several inetabolitea in poultry tissue and eggs. If it is determined that any or all of’ these
metabolites are of concern, additional validated enforcement n4tliods for residues in poultry and eggs will be
required. The nature or the residue in ruminants has not been adequately described. On receipt of’ the data
requested In Nature of the Residue In Plants and Nature of the Residue In Animals, the conclusions stated here
regarding the acceptability of methods for data collection and enforcement may change.
5/ Data are needed reflecting the frozen storage stability ol’ difl.ubenzuron In representative animal coninoclities
fortified at levels of 0.05 ppm at Intervals up to 15 months.
6/ Data are required for four additional members of this crop group ( Phaseolus app. — one succulent and one dry; and
Plaum app. — one succulent and one dry). Presently, soybeans are the only member of this crop group for which
a registered dIf ’lubenzuron use eciats.
31
-------
TABLE A
0ENE 1IC DATA REQUIREI4EIfFS 10R DIFWB NZUR I I
158.125 Residue Chemistry — Continued
7/ Tolerances of 0.5 ppm have been proposed for the residues of diflubenzuron in or on grapefruit and oranges
(Section 1?, PP#1F2507, 1981). Tolerances of 0.3 ppm and 20 ppm have also been proposed for the residues of
diflubenzuron in the dried pulp and oil, respectively, of members of the citrus fruits groups (Section F,
PP#1F2507, 1981). A conclusion as to the adequacy of these proposed tolerances will not be made at this
time since data autmitted in support of the proposed tolerance are under review.
8/ Data eutziiltted in support of registrations for pears and apples are currently under review.
9/ A crop group tolerance is not appropriate at the present time for the following reasons:
The available data sutinitted in support of the tolerance for residues In pasture grass do not specify
which, If any, representative coarnodities of this crop group (Bermuda grass, bluegraes and bromegrass
of fe8cue) were represented. Data Identifying species of’ grass treated must be sutinitted.
The presently registered use on pasture grass Is highly restrljcted. Only irrigated crops in central CA
may be treated.
) O/ Residues of’ dlflubenzuron must be determined in or on first, second, third, fourth and fifth flush mushrooms
treated at spawning (incorporation of the 25% WP into compost at 2.5 lb ai/2500 sq. ft. of compost) and
at casing (thcorporated or applied as a drench at 0.527 lb ai/2500 sq. ft. of casing soil).
11/ The conclusion that the data are ailequate 13 tentatIve. The metabolism of diflubenzuron In ruminants and the proper
— storage stability of diflubenzuron In animal tissues are not adequately understood. See footnote 5/ above.
38
-------
1 ‘ l . 130 Eriv 1 rorinien La 1 Id I c D i Ca fle u I rutier t
I)11J1(ADAT]()N fltJDJkS—LAU : -
lül—l - hydrolysis IUAI or PAIIlI
Ihoto11e radat Ion
l l—2 — in water
161—3 — On soiL.
1 61_ I l — in Air
h4l IM )I ,i M S ’llJL)I L S—LAIi :
1 62—] — Aerohiic Soil L JA1 or PAulA
162—2 — Anacrobic Soil UAI or PAIRA
162—3 — AIIderOhi UUdCIC
— Acrobic A 1 UsLIL
I i)bl L. L’1Y 1’tJl )1 ES:
Jtj3—l — Lcctchi1r tiid
A’ hoi t I orl/l)cbOrfJI lui
I(3—2 — VuI iIh L.it.y (L,ah)
11 ,3—3 — VoLilhilty (Iluld)
No Yes?!
No Yes 8 !
No Yes 9 !
1/
DiLU Ilequ irciiierit Cc iipos1t ion
Use 2/
Pat 1cm
TABLE A
GENL ]UC DATA REQUIREMENTS 10R DIP LJDENZUHCt’1
Does EPA Have
Data To Satisry
‘this Ilequ ire—
nient? (Yes. No
or Partially)
Be Sutinitted Under
FIFRA § 3(c)(2)(B)?
Bibliographic
Citation
Time Frame for Data
Sutiniss ion 3/
IUAI or
‘Lk]AI or
¶IOAI or
L’AIUA
PAulA
PAulA
A)I3,E ,G
Partial
00039’I Bl
A B G
No
Yes
A)U,G
No
Yes
AU
- No
Yes
A,E3JE,0
Partial
00115665
A,U
No
————
I AI
or
PAIItA
U
‘iUi ’
or
l’Al l(/\
None
No
Yea 6 !
Yes
Yes 6 /
No
5 /
5,
9 Months
5/
5/
5/
5 ,
12 Months
15 Months
1lJ
39
-------
158.130 Enviromental Fate — Continued
DISSIPATION STUDIES-FIELD :
16 1 1—i — Soil
1611-2 — Aquatic (Sediment)
1611—3 — Forestry
16’i- 1 1 — Combination and
Tank Mixes
1611-5 — Soil, Long—term
ACCUMULATION S’IIJDT!3 .
165-1 - Rotational Crops
(Confined)
165-2 — Rotational Crops
(Field)
— Irrigated Crop3
— In Fish
- In Aquatic Non-
Target Organisms
1/
‘ata Requirement Composition
Use 2/
Pattern
TABLE A
GENEIIIC DATA REQUIREMENTS I OR DIFUJBENZURCt I
Does EPA Have
Data To Satlsry
This Require-
ment? (Yea. No
or Partially)
Must Additional Data
Be Submitted Under
Bibliographic
PIFRA S 3(c)(2)(B)?
Citation
Time Frame for Data
SubmissIon 3/
TEP
A,B
No
——
YealO ! 27 Months
TEP
None
No
--
No
TEP
0
No
--
.
YealO! 27 Months
None
No -
-—
No 11 !
TEP
A,B
No
——
No (dissipates
rapidly)
Al)
Partial
0007 10V 1
Ye8 12 ! 39 Months
TEP
AB
No
--
13/
TEE ’
None
No
No
‘fiAT
or PAIRA
A,B,O
No
Yeal 11 / 12 Months
6
Partial
00099897
Reserved 15 !
165—3
165— l i
165-5
-------
TABLE A
0 J4ERIC DATA REQUIREMEJ F]S FOR DIPWB1 4ZURC11
9
§158.130 Environmental Pate — Continued
1/ Ccmposition: ‘IGAI = Technical grade of’ the active 1n redlent; PAIRA = Pure active ingredient, radlolabelled;
TEP = Typical end-use product.
2/ The use patterns are coded as follows: A Terrestrial, Food Crop; B = Terrestrial, Non—Food; C Aquatic 1 Food Crop;
D = Aquatic, Non-Pood; E Greenhouse, Food Crop; P Greenhouse, Non-Food; 0 Forestry; H Dcinestlc Outdoor;
I Indoor.
3/ Data must be sutxnltted within the indicated time frames, based on the date stamped on the front of this document.
11/ This study partially fills data requirements by providing information on the hydrolysis of parent and
— identification of two degradates at pH 5, 7 and 9. To completely satisfy the requirement all degradatea
whose yields are >10 at any time during the study must be qualitatively and quantitatively identified.
Additional environmental fate and product chemistry data required as noted in 7/271811 Ground Water Special
Data Call In letter
5/ Data utynitted Is being reviewed.
6/ This study will lulfill the requirement if the purity of test substance, soil extraction procedure and
soil GEE (Cation exchange eqiiiva1 ’nt) are supplied. Additional data required as noted in 12/11/811 Ground
Water Special Data Call In letter.
7/ Adsorption/de sorptiOfl studies on four soils representative of usage are required. A batch equilibrium study
on four soils typical of usage is required for greenhouse use and will satisfy data requirements for all other
uses. An aged study is also required. Additional data required as noted in 12/11/811 Ground Water Special Data
Call In letter.
8/ Sutinit vapor pressure only. Depending on compound volatility, Agency may require this test.
I ll
-------
TABLE A
GENERIC DATA REQUIRF14EWI’S FOR DIFIJJBENZURC*I
10
§158.130 Envirorinental Pate — Continued
9/ Data may be required, depending on results of Laboratory Volatility study.
10/ All degradates for d in th laboratory teat that occur in yields >10% should be looked for (and
measured if found), when fe .Ible, In the field 8tUdiee. This data requirement may be waived if
the registrant can provide data to show that 2,6-dlfluorobenzolc and p—chloroanhline (in sane studies)
were looked fore Including limits of detection of method and degradate levels found. The Agency recognizes
that the low application rate and/or rapid degradation may have made this impractical but registrant Is
encouraged to utinit waiver request and demonstrate a “best effort” was made. Additional envirorinental
fate and product chemistry data are required as noted In 7/27/81 1 Ground Water Special Data Call In letter.
11/ Not required at this ti-me because this Standard only addresses single active ingredient products.
12/ Study #000710711 partially fulfIlls data requirements by demonstrating that corn, soybeans, and potatoes
rotated into sefl treated 10 weeks earlier with radlolabeled dlflubenzuron can take up diflubenzuron
p—chlorophenyl “rea, and/or uni’ientlfied radioactive compounds. Additional studies are required to determine
the nature and amount f dIflubt iron and/or Its residues taken up by leafy vegetable crops, root and amall
grain crops grown in diflubenzuron—treated soil. See PesticIde Assessment Guidelines, Subpart N, Environmental
Fate, for details.
13/ May be required, depending on results from the Confined Rotational Crop study.
i’l/ Registrant should autinit octanol/water partition coefficient (and temperature) first. For details, see Sectiai
158.120 Product Chemistry Data Requirements, Subdivision D — Product Chemistry Assessment Guidelines, available
fran National Technical Information Services (Springfield, VA), Order No. PB83-l53890, (703) 1187_11650.
15/ May be required, depending on results fran 165-11.
l2
-------
8.135 Toxicology Data Requirements
tCLYI’E TESTING :
1—1: Oral Rat 00091l9 ll
11-2: Dermal LA) 50 00070027
11—3: Inhal. LC 50 t 0009 9’l2
1—il: Primary Eye
Irr. Rabbit
11—5: Primary Dermal
Irr. Rabb.
¶IOAI A,B ,E,G Yes 00038706 No
TGAI A,B,E,Q Yes 00038715 No(’I)
1/
.a Requirement Co.npoaition
Use 2/
Pattern
TABLE A
OFJ1ERIC DATA REQUIREMENrS FOR DIJBE}1ZLJRC 1
Does EPA have
Data To Satisfy
This Require—
ment? (Yea, No
or Partially)
Must
Be SuL n1tted
Bibliographic
FIFRA § 3(c)(2)(B)?
Time Frame for Data
Sutinlaslon 3/
‘IUAI
A,B,E0
Yea
II UAI
AB,E,0
Yea
‘ IUAI
A,B,EJ0
Yes
‘ lUAI
AJB,E,G
No
No
No
No
Yes
NA
11—7: Acute Delayed
Neurotoxicity
Hen
UBCHRONIC TESTING :
12—1: 90 Day Feeding
Rodent, Non-
Rodent
12—2: 21 Day Dermal
9 Months
Yea
NA
00038715 No
00070027
NA
‘$3
-------
TABLE A
12 GENERIC DATA REQ JIRI 24ENTS [ OH DIFUJBE 4ZURON
.
Data Requirement
.
1/
Ccniposition
Use 2/
Pattern
Does EPA Have
Data To Satiat’y
This Require-
ment? (Yea, No
or Partially)
Bibliographic
Citation
Must Additional Data
Be Sutinitted Under
PIFRA § 3(c)(2)(B)?
Time Frame for Data
Sutmiaalon 3/
§158.135 ToxIcology
(continued)
82-3: 90 Day Derm i
¶T3AI
NA
NA
82—’l: 90 Day Inhal-
tion, Rat
‘I 1AI
NA
NA
82—5: 90 Day Neuro—
toxicity/lien
Man.ual.
mAl
AI
NA
NA
ClIHOtIIC TESTING
83—1: Chronic Feeding
2 SpecIes: Rod.
¶IUAI
A,BE,G
‘! ea
GSOillil -006,
0001 l’1329
0S01 1 1 1 1—007 No
Non-Rodent
IIUAI
A,BE,O
5/
5/
83_2: Oncogenicity
2 SpecIes, Hat
& Mouse preferred
‘IUAI
AB ,E,0
Yes
GSO1’Pi—006,
GS014 l—O07 No
I II
-------
TABLE A
GEHERIC DATA REQUIRt 4EWl 1 S 1k R DIFLJJBENZIJRW
)ata Requirement
1/
Cc*npoaltlon
Use 2/
Pattern
Does EPA Have
Data To Satist’y
This Require—
ment? (Yea, No
or_Partially)
Bibliographic
Citation
Must Additional Data
Be Su initted Under
FIPRA § 3(c)(2)(B)?
Time 1?rame for Data
Sut n1aa1on_3/
l58.135 Toxicology
C tinu 1)
3—3: Teratology
2 Species
‘ItlAl
ACE
Yea
0001111326
0001111327
No
3—’1: Reproduction,
2 Generation
‘DIAl
ACE
Yea
0001111330
No
1tTPAGE ICITY TESTING
‘ItlAl
ACE
Y) s.
00069870
000603611
No
I 1-l: aene Mutation
‘I-2: Chromosctnal
Aberration
‘DIAl
ACE
Yes
00069871
No
I l l— li: Other Mechanisms
DNA
D IAl
ACE
No
Yes 12 Months
“5
-------
TABLE A
GENERIC DATA REX UIItEI4EffPS FOR DIPLJJBENZURON
Does EPA Have
Must Additional Data
Data To Satisfy
Be Sut*nitted Under
1/
Use
2/
This Require-
Bib].iographlc
.
FIFRA S 3(c)(2)(B)?
Data Requirement
Ccznpositlon
Pattern
ment? (Yes. No
or Partially)
Citation
Time Frame for Data
Submission 3/
§158 .135 Toxicology
(Continued)
SPECIAL TESTING
85-1: General Metab.
PAl or PAIRA( 6 )
ACE
Yea
00038708
No
86-1: Daneatic Animal
Safety
Ponnulatlons
HI
No
No
(1) Cctnposition.: IUAI Technical Grade of the Active Ingredient
(2) Use Pattern Codes: A = Terrestrial, Food Crop; B = Terrestrial, Non—Food; C Aquatic, Food Crop; D Aquatic
Non-Food; E Greenhouse, Food Crop; P Greenhouse, Non-Food; (I Forestry; H Danestic Outdoor; I Indoor.
(3) Data must be submitted within the indicated time frames, based on the date stamped on the front of this document.
(ii) This study, 82—2, together with 81—2 will also serve to support the requirement for 81—5.
(5) Data in review.
(6) PAI=Purlfied Active Ingredient; PAIRA=Purified Active Ingredient Radiolabled.
-------
TABLE A
0Ei I DATA R1 UIR 4EI 11’S FOR DIPIJJBENZUR(11
Doea
To
Be Sutinitted Under
PII?RA § 3(c)(2)(B)?
‘ata Requirement
1/
Canposition
IJae 2/
Pattern
ThIa Require—
ment? (Yea, No
or Partially)
Citation
Time Frame for Data
Sutiniaslon 3/
158.1115 Wildlife and
Aquatic Organiama
AVIAN AND MAMMALIAN TESTIUJ
‘ [ GAl
A,G
Yea
00073935
00073936
000386111
No
71-1 — Avian Oral LD 50
71-2 — Avian Dietary LC j
a - waterfowl
! IOAI
A,O
•
Yea
p
00039080
00060381
No
b — upland game
¶ IOAI
A,0
Yea
•
00038613
00060381
No
71-3 — Wild Mani a1 Toxicity
‘ [ GAl
A,0
N/A
N/A
N/A
71—il — Avian Reproduction
‘ [ GAl
A,G
Partially
00099719
00099862
00099730
Yea 11 f 211 Montha
71-5 — Simulated arwi Actual
‘ [ GAl
A,G
Partially
G 3 0i 1 1’i—O lO
039999-001
Reeerved 5 /
Field Teating — Marnna ls
and Birds
“7
-------
16 TABLE A
GENERIC DATA REQUIRI 4EWFS 1 OR DIF’LJJBENZURON
Does EPA Have
Must
Data
Requirement
1/
Ccai position
Use 2/
Pattern
Data To Satisfy
This Require—
ment? (Yes No
or Partially)
Bibliographic
Citation
Be Submitted tinder
FIPRA § 3(c)(2)(B)?
Time Frame for Data
Submission 3/
§158.1115 Wildlife and
Aquatic Organisms — Continued
AQUATIC ORGANISM TESTING
72-1 — Freshwater Fish ‘JWJ A,G Yes 00003503 00056035 No
a- warmwater 00056150 00060376
GS O 1 II’1-012
TEP 0 Yes 00003503 00056150 No
00060380 000603811
b— coidwater ‘fOAl A,G Yes 00003503 00056150 No
03011111—012
TEP 0 Yea 00003503 00056150 No
00060380 000603811
72-2 — Freshwater Invertebrate ¶10A1,TEP A,0 Partially 00003503k 03011111-012 Yes 6 ! 9 Months
Acute
72—3 — Eatuarthe/Marine
Organism Acute ‘fOAl A,0
a— shrimp Yes 00038612 00039088 No
030 1 1 1 11—009
b— finfish Partially 00056150 Yes 7 ! 12 Months
c— oyster Partially 00038611 00039088 Yes?! 12 Months
118
-------
17 TABlE A
GE}IEHIC DATA REQUIREI4ENTS FOR DIP1JJBF 4ZURON
Does I PA Have
Must Additional Data
Data To Satisfy
Be Sub itted Under
Data
Requirement
1/
Ccznposition
use 2/
Pattern
This Require—
ment? (Yes,
or Partially)
No
Bibl1ogra * ie
Citation
F’IFRA S 3(c)(2)(B)?
Time Frame for Data
Sutinisaion 3/
5158.1115 Wildlife and
Aquatic Organisms — Continued
72—11 — Fish Early-Life Stage ‘ AI
and Aquatic Invertebrate
Life—Cycle
a— flnfleh
i - freshwater A,0 Yes 00099755 No
ii — estuarine A Partially 0009972 Reserved 8,
b— aquatic invertebrate A,G Partially 00010856 Yes 9 / 15 Months
I - freshwater A,U 03011111—008
ii - estuar lne A Partially 00038612
03011 1 11-009
72-5 — Aquatic Organism IXIA I AU t 4/A N/A
Accumulation
72—6 — Life—Cycle Tests with ¶ITIAI
Fin fish
I — freshwater AU Partially 00099755 Reserved 8,
Ii — estuarlne 00099722 Reserved /
72-2 — Simulated or Actual TEP A,U Partially o5 0 0o8’ui Reserved 10/
- Field Testing — Aquatic 00099897 00038213
00099791 00071210
00099891 00099839
00038212 00039090
00039091 00039092
00095 I16 00099678
00099895 00039095
‘19
-------
18 TABU A
GENERIC DATA HEQ(JIREMEUP3 FOR DIFUJBENZURCI1
§158.1115 Wildilife and Aquatic Organisms — Coritthu&I
1/ Ccinposition: TUAI = Technical grade of the active ingredient; PA l pure active ir*gredient;
— TEP = Typical end—use product;
2/ The use patterns are coded as follows: A Terrestrial Food Crop; B = Terrestrial, Non-Food Crop; C Aquatic,
Food Crop; D Aquatic, Non-Food; E Greenhouse, Food Crop; F Greenhouse, Non-Food; 0 Forestry; H Domestic
Outdoor; I = Indoor.
3/ Data must be autxnitted within the indicated time frames, based on the date stamped on the front of this document.
II, Avian reproduction studies ar’- required since repeat applications are allowed on all uses and potential reproductive
Impainnent is suggested by the vailable data.
5/ Reserved pending results from avian reproduction tests and pertinent environmental fate studies.
6/ An aquatic invertebrate acute toxicity test with technical material is a basic requiroment.
7/ Acute toxicity test8 with estuarine firifish and oysters are rec4iired as part of. the estuarine/marine battery
of testing required of all uses with substantial coastal acreage (i.e., cotton and soybeans).
8/ An estuarine finfish chronic toxicity test is reserved pending the results from the acute estuarthe finlish
toxicity test and pertinent environmental fate infonnation.
9/ An aquatic invertebrate chronic toxicity test is required since repeat applications are allowed and the available
information indicates the potential for chronic hazard to aquatic invertebrates.
The test should indicate a no observable effect level.
10/ Full—scale aquatic field testing is reserved pending the results of’ the requested laboratory data and pertinent
environmental fate studies. The available information, including some partially acceptable field studies, strongly
suggest a substantial hazard to aquatic invertebrates which would require a field study to negate these concerns.
Additionally such a field study may require an investigation of’ potential secondary impact to finfishes from
reduction of their food supply.
50
-------
TABLE A
0D lEflIC DATA REQUIREMENTS Ik)H DIFUJBENZUR(N
Does
EPA Have
.
Must
Data
To Satisfy
Data
Be Submitted Under
ata
Requirement
1/
Cc posit1on
U8e 2/
Pattern
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
FIFRA 3(c)(2)(8)?
Time Frame for Data
Submission
158.150 Plant Protection Data Requirements
121-1 - TARGET AREA EP No No 3/
PHYTcYmxIciTy —
)3NTARGEF AREA PlIYI YIOXICITY
TIER I
122-1 - Seed Germination! ¶IUAI No No 3/
Seedling Dnergence
122-1 — Vegetative Vigor ThAI No No 3/
122—2 - Aquatic Plant Growth No No 3/
TIER II
123-1 — Seed Germination! T hAI No No 3/
Seedling Duergence
123-1 — Vegetative Vigor ThAI No No 3/
123—2 — Aquatic Plant Growth ThAI No No 3/
TIER III
12’i—I — Terrestrial Field PEP No No 3/
1214-2 — Aquatic Field PEP No No 3/
/ Ccinpoaitlon: ThAI = Technical grade of the active Ingredient; PEP = Typical end-use product. EP = End-use product .
/ ‘1’he use patterns arelcoded as follows: A = Terrestrial, Food Crop; B Terrestrial, Non—Food Crop; C = Aquatic,
Food Crop; D = Aquatic, Non-Fo ‘ E Greenhouse) Food Crop; F = Greenhouse, Non—Food; U = Forestry; H = Domestic
Outdoor; I = Indoor.
/ These requtrerneilta ‘r genera1 waived unlesi it Is believed there is a phototoxicity problem.
51
-------
20 TABLE A
GENE]uIC DATA REQUIRU 4Et1TS FOR DIPUJBENZIJRCI4
Does EPA Have Must AcIdltlOflaJ. Data
Data To Satisfy Be Subnitted Under
1’ Use 2/ This Require- Bibliographic PIFRA § 3(c)(2)(B)?
Data Requirement C npo sition Pattern ment? (Yes, No Citation Time Frame for Data
or Partia1ly) Sutiniaaion _____
§158.155 Nontarget Insect
NONTABGEr INSECF TESTING -
POLLINA’lDRS :
i’ll—i — Honey bee acute ¶IUAI A,B ,G Yea 00099890
contact: toxicity 05001991 No
141—2 — Honey bee — toxicity
of residues on
foliage ‘lEP A,B,G Yes No3/
i4 1—’i — Honey bee subacute
feeding study [ Reserved] 1 1/ I
141—5 — Field testing for 00071212 No
pollinators TEP AB,G Yes ooo7i8i6
00099743
00099762
1/ Ccznpositlon: ¶IUAI = Technical grade active ingredient; TEP = Typical end-use product.
2/ The use patterns are coded as follows: A = Terrestrial 1 Food Crop; B = Terrestrial, Non-Food; C = Aquatic,
Food Crop: D Aquatic, Non-Food; E = Greenhouse, Food Crop; P = Greenhouse, Non-Food; (I = Forestry; II Dcineatic
Outdoor I = Indoor.
3/ As acute contact test shows little or no toxicity to bees, no further testing is required.
1i/ Requirement reser”2u , ncIini develo ent of test methodology.
52
-------
21 TABLE A
GENERIC DATA REQUIREMENTS FOR DI1?IJJBENZLJR(11
Does EPA Have
Must Additional Data
Data To Satisfy
Be Sutznitted Under
Data
Requirement
1/
Cc*npoaition
Use 2/
Pattern
This Require—
ment? (Yes,
or Partially)
No
Bibliographic
Citation
F’IFRA § 3(c)(2)(B)?
Time Frame for Data
Sutinisaion 3/
§158.155 Nontarget Insect
(continued)
NOI TARGEF INSECT TESTING -
AQUATIC INSECTS :
1 i2—1 — Acute toxicity to
aquatic insects [ Reserved] 3 !
1 I2—1 — Aquatic insect
life-cycle study [ Reserved] 3 !
1 i2—3 — Simulated or actual
field testing for
aquatic insects [ Reserved] 3 !
1t13-1 - NONTARGET INSECT TESTING-
thru PREDA 1OR ANt) PARASITES
l I3—3 [ Reserved] 3 !
1! Ca poait1on: R]Ai = Tecn .i aI gra c active ingredient; PEP = Typical end—use product.
2! The use patterns are coded as follows: A = Terrestrial, Food Crop; B = Terrestrial, Non-Food; C = Aquatic,
Food Crop; D = Aquatic, Non-Food; E = Greenhouse, Food Crop; F = Greenhouse, Non-Food; G = Forestry; It = Dci estie,
Outdoor; I = Indoor.
3/ Reserved pending Agency decision as to wether the data requirement should be established.
53
-------
TABLE B
PRODUCT SPFCIPIC DATA REQUIRI 741 }(FS R)R MANUPACIIJIUW-LJSE PFE) [ XJCTS CONTPJNINO DIF [ JJB ZLJROH
Data Must Be
Submitted Within
Time Frames Listed
Below 1
61-3 — Discussion of Formation of t4P R [ ]
Impurities
Analysis and Certification of Product
Iri red1ents
62—1 — Preitminary Analysis MP CR [ 1]
62-2 — Certificatir of ‘lr’ ta MP Ft Ii].
62—3 — Analytical Methods for MP Ft [ x l
Enforcement of limits
Phyaical and Chemical Properties
63-2 — Color MP H
63-3 — Physical State MP Ft
63-’I - Odor MP Ft { ]
[ ]
i: i
Cl
[ ii ]
Cl
1T]
[ 1
6
6
6
12
12
12
Months
Months
Months
Months
Months
Months
Cl ______________ 6 Months
[ :11] ______________ 6 Months
1] ______________ 6 Months
22
Guideline Citation and
Test
Guidelines
Are
Data
Footnote
Name
of Test
Substance
Status
Required
Yes No
Number
158.12O Product Chemistry Data Requirements
Product Identity :
61—1 — Product Identity and Disclosure
of Ingredients
61-2 - Statement of Cctnpoaitlon
MP
H
R
-------
23
TABLE B
PRODUCT SPECIFIC DATA RE UIRE 4El (PS Jk)R MANUFACIURINO-USE PRODUCTS CONTAINING DIFWBE ZURON
Data Must Be
Guideline Citation and Teat Guidelines Are Data Footnote Sutinitted Within
Name of Teat Substance Status Required Number Time Frames Listed
Yes No Below 1/
S158.120 Product Chemistry (Continued)
Physeal and Chemical Properties
(Continued)
63-7 - Density, Bulk Density, or NP R I i i ____________ 6 Months
Specific Gravity
63-12 - pH NP CR Ii] (TI ____________ 6 Months
63-14 — Oxidizing or Reducing NP CR Ii] [ TI ____________ 6 Months
Act ion
63-15 — Flanmability NP CR [ i ] IT] _____________ 6 Months
63-16 — Explodability ME ’ H Ii] IT] ____________ 6 Months
63-17 — Storage Stability ME’ 11 ( ] (TI ____________ 6 Months
63-18 — Viscosity NP CR E ] IT] _____________ 6 Months
63-19 — Miscibility ME’ Cit 1 ] IT] _____________ 6 Months
63-20 — Corrosion Characteristics ME’ H [ ] IT] _____________ 15 Months
Other Requirements :
6 11- 1 — Sulinittal of samples ME’ CR [ x l _____________
M1 = Manufacturing-use Product; H Required; CR = Conditionally Required
1/ Data muit be auI)rulltted wlLhin the indicated time frame , based on the date stamped on the front of this document.
55
-------
TABLE B
2 1 1 PRODUCT SPECIFIC DATA RE tJIREMENPS FOR MANLJPAC’IURING-USE PRODUCTS CONTAINING DIPUJBE 4ZUR0N
Does
EPA Have
Must Additional Data
Data
To Satisfy
Be Sut itted Ur ier
Data
Requirement
!/
Composition
This Require—
went? (Yea,
or Partially)
No
Bibliographic
Citation
PIFRA 3(c)(2)(B)?
Time Frame for Data
Submission 2/
158.135 Toxicology Data Requirements
ACUTE TESTING
81-i — Acute Oral Toxicity - Rat MP Yes 0009119111 No
81-2 — Acute Dermal Toxicity MP Yes 00070027 No
- Rabbit
81-3 — Acute Inhalation Toxicity NP Yes 0009119112 No
-Rat
8 1-’i — Primary Eye 4P No Yes 9 Months
Irritation - Rabbit
81-5 — Primary Dermnal MP Yes 00038715 No
Irritation - Rabbit 0007007
81-6 — Dermal Sensitization - NP No Yes 9 Months
Guinea Pig
1/ Cmpositlon: NP Manufacturing-use product.
2/ Data must be subuitted within the indicated time frame 1 based on the date stamped on the front of this document.
56
-------
REQOIREMENT FOR SUBMISSION OF GENERIC DATA
A. This portion of the guidance document is a Notice
issued under the authority of FIPRA sec. 3(c)(2)(B). The
tables following this section list the data required for
maintaining the registrability of each product.
EPA has determined that additional generic data described
in Table A must be submitted to EPA for evaluation in order
to maintain in effect the registration(s) of your produ.ct(s)
identified as an attachment to the cover letter accompanying
this guidance document. As required by FIFRA sec. 3(c)(2)(B),
you are required to take appropriate steps to comply with
this Notice.
EPA may suspend the registration of each of those products
unless, within the specified time, you have informed EPA how
you will satisfy the requirements of this Notice. Any such
suspension will remain in effect until you have complied with
the terms of this Notice.
B. What Generic Data 1 ! Must be So-bmitted . You may deter-
mine which generic data you must submit by consulting Table A
at the end of this chapter. That table lists the generic
data needed to evaluate the continued regi.strabillty of all
products, and the dates by which the data must be submitted.
The required studies must be conducted in accordance with
EPA approved protocols (such as those contained in the Pesticide
Assessment Guidelines 2/ or data collected under the approved
protocols of the Organization for Economic Cooperation and
Development (OECD). If you do riot wish to develop data
in support of certaIn uses appearing in your labeling, you
may delete those uses at the time you submit your revised
labeling.
For certain kinds of testi.ig (generally ecological
effects), EPA requires the te3 substance to be a r typical
formulation,” and in thr ;j cases EPA needs data of that type
1/ Generic data pertain t the properties or effects of a
particular ingredient, and thus are relevant to an evaluation of
the risks of all products c’ ntainIng that ingredient, regardless
of the product’s unique com .c. i.tion or specific use. Product-
specific data relate only to the properties or effects of a
product with a particular composition (or a group of products
with closely similar composition).
2/ The Pesticide Assessment Guidelines are available in hard
copy or microfiche from the National Technical Information
Service, 5285 Port Royal Road, Springfield, Va. 22161.
57
-------
for each major formulation category (e.g., emulsifiable concert—
trates, wettable powders, granulars, etc.) These are classified
as generic data and when needed are specified in Table A.
EPA may possess data on certain “typical formulation&’ but
not others. Note : “Typical formulation” data should not be
confused with product—specific data (Table E which are
required on each formulation. Product-specific data are
further explained in Chapter III of this document.
C. Options Available for Complying With Requirements
to Submit Data
Within 90 days of your receipt of this Notice you must
submit to EPA a completed copy of the form entitled “FIPRA
Section 3(c)(2)(B) Summary Sheet” [ EPA Form 8580—1, Appendix
11—3] for each of your products. On that form you must state
which of the following methods you will use to comply with
the requirements of this Notice:
1. (a) Notify EPA that you will submit the data, and
(b) either submit the exist g data you believe will
satisfy the requirement, or state that you will generate
the data by conducting testing. If the test prdcedures
you will use deviate from (or are not specified in) the
Pesticide Assessment Guidelines or protocols contained in
the Reports of Expert Groups to the Chemicals Group,
Organization for Economic Cooperation and Development
(OECD) Chemicals Testing Programme, you must enclose the
protocols you will use.
OR
2. Notify EPA that you have entered into an agreement
with one or more other registrants to jointly develop (or
share in the cost o developing) the data. If you elect
this option, you m’ .t notify EPA which “egistrant(s) are
parties to the agreement.
OR
3. File with EPA a completed “Certi.ftcation of Attempt to
Enter Into an Agre€ment With Other Registrants for Develop—
merit of Data’ (EVA Porm 8580—6, Appendix II—14)’/
1/ FIFRA sec. 3(c)(2)(B) authorizes joint development of
data E y two or more registrants, and provides a mechanIsm by
which parties can obtain an arbitrator ’s decision if they agree
to jointly develop data but fail to agree on all the terms of
the agreement. The statute does not compel any registrant to
agree to develop data jointly.
(Footnote continued on next page)
58
-------
OR
Ll . Request that EPA amend your registration by deleting
the uses for which the data are needed. (This option is
not available to applicants for new products.)
OR
5. Request voluntary cancellation of the registration(s)
of your products for which the data are needed. (This option
is not available to applicants for new products.)
D. Procedures for Requesting Changes in Testing Methodology
and Extensions of Time
EPA recognizes that you may disagree with our conclusions
regarding the appropriate ways to develop the required data
or how quickly the data must be submitted. If the test
procedures you plan to use deviate from (or are not specified
in) the registration guidelines or protocols contained in
the reports of the Expert Groups tothe Chemical Groups,
Organization for Economic Cooperatie and Development (OECD)
Chemicals Testing Programme, you must submit the protocol
for Agency review prior to the initiation of the test.
If you think that you will need more time to generate the
required data than is allowed by EPA’S schedule, you may
submit a request for an extension of time. The extensIon
request must be submitted in writing to the Product Manager.
(Footnote continued from previous page)
In EPA’s opinion, joint data development by all regis-
trants sub3ect to a data requirement or a cost—sharing agreement
among all such r( istrants is clearly in the public interest.
Duplication of testing could increase costs, tie up testing
facilities, and subject an unnecessarily large —umber of
animals to testii g.
As noted ea..’lier, EPA has discretion to suspend the
registration o product when a registrant fails to submit data
required under PFRA Section 3(c)(2)(3). EPA has concluded that
it should encurage joint testing rather than duplicative
testing, and t t suspension should be withheld in certain cases.
to further this goal. Accordingly, If (1) a registrant has
informed us of his intent to develop and submit data required
by this Notice; and (2) a second registrant informs EPA that
it has made a bona fide offer to the first registrant to share
in the expenses of the testing Eon terms to be agreed upon
or determined by arbitration under FIFRA Section 3(c)(2)(B)(iii)];
and (3) the first registrant has declined to agree to enter
into a cost—sharing agreement, EPA will not suspend the
second firms registration.
59
-------
The extension request should state the reasons why you believe
that an extension is appropriate. While EPA considers your
request, you must strive to meet the deadline for submitting
the required data.
III. REQUIREMENT FOR SUBMISSION OF PRODUCT-SPECIFIC DATA
Note: Unless stated otherwise in Section I, Regulatory
Position and Rationale, this Section applies only to manufac-
turing use products, not to end use products.
A necessary first step in determining which statements
must appear on your product’s label is the completion and
submission to EPA of product—specific data’ listed on the
form entitled “Product Specific Data Report” (EPA Form
8580—4, AppendiX i l l—i) to fill gaps identified by EPA
concerning your product. Under the authority of FIFRA sec.
3(c)(2 (B), EPA has determined that you must submit these
data to EPA in order to reregister your product(s). All of
these data must be submitted not later than six months after
you receive this guidance document.
Table B__product-Specific Data Requirements for ManufacturIng
Use Product8 ”liSt3 the product specific data you must submit.
Data that are required to be submitted are identified in the
column of those tables entitled “Must Data By Submitted
Under §3(c)(2)(B).”
IV. SUBMISSIOt’ OF REVISED LABELING
Note : This section applies to end use products only to the
extent described in Section I (Regulatory Position and
Rationale). Otherwise, the following information pertains
exclusively to manufacturing use products.
FIY requires each product to be labeled with accurate,
complete and suffi ent instructions and precautions, reflecting
the res.. its of dai. a concerning the product and its ingredients.
Labelirg requirements are set out in L O CFR 162.10 (see
Append .X v-i) and are summarized for products containing
this a. t ve ingredient as part of this Guidance Document
(See A pmdiX IV—2). Applications submitted in response to
this rotice must include draft labeling for Agency review.
4/ Product specific data pertain to data that support the
formulation which is marketed; it usually includes product
chemistry data and acute toxicity data.
60
-------
If you fail to submit revised labeling information
complying with this section (supplemented by requirements
described in Section I, Regulatory Position and Rationale),
EPA may issue a notice of intent to cancel the registration
under PIPRA sec. 6(b)(1).
A. Label Contents
140 CFR 162.10 requires that certain specific labeling
statements appear at certain locations on the label. This
is referred to as format labeling . Specific label items
listed below are keyed to Appendix IV—2.
Item 1.. PRODUCT NAME — The name, brand or trademark is
required to be located on the front panel, preferably centered
in the upper part of the panel. The name of a product will
not be accepted if it is false or misleading.
Item 2. COMPANY NAME AND ADDRESS - The name and address
of the registrant or distributor is required on the label.
The name and address should preferably be located at the
bottom of the front panel or at theend of the label text.
Item 3. NET CONTENTS — A net coz terits statement is
required on all labels or on the container of the pesticide.
The preferred location is the bottom of the front panel
iediately above the company name and address, or at the end
of the label text. The net contents must be expressed in the
largest suitable unit, e.g., “1 pound 10 ounces” rather than
“26 ounces.” In addition to English units, net contents may
be expressed in metric units. See Appendix IV—l. [ 140 CFR
162 .10(d)]
Item 14. EPA REGISTRATION NUMBER — The registration
number assigned to the pesticide product must appear on the
label, preceded by the phrase “EPA Registration No.,” or “EPA
Reg. No.” The registration number must be set in type of a
si and style similar to other print on that part of the
label on which it appears and must run parallel to it. The
reg ..stratiofl number and the required identifying phrase must
nr.,t appear in such a manner as to suggest or imply recommendation
o Endorsement of the product by the Agency. See Appendix IV— ) ..
[ 40 CFR 162.10(e)]
Item 5. EPA ESTABLISHMENT NUMBER - The EPA establishment
m”nber, preceded by the phrase “EPA Est.” is the final estab—
lishment at which the product was produced, and may appear
in any suitable location on the label or immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment number on the trnmed±ate
container cannot be clearly read through such wrapper or container.
See Appendix IV— ) .. [ 140 CPR 162.10(f)]
61
-------
Item 6A. INGREDIENTS STATEMENT — An ingredients statement
is required on the front panel. The ingredients statement m’ist
contain the name and percentage by weight of each active ingredient
and the tQtal percentage by weight of all inert ingredients.
The preferred location is immediately below the product name.
The ingredients statement must run parallel with, and be clearly
distinguished from, other text on the panel. It must not be
placed in the body of other text. See Appendix IV -1. [ 40 CFR
162.l0(gfl
Item 63. POUNDS PER GALLON STATEMENT — For liquid agricul-
tural formulations, the pounds per gallon of active ingredient
must be indicated on the label.
Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS - Front panel
precautionary statements must be grouped together, preferably
within a block outline. The table below shows the minimum type
size requirements for various size labels.
Size of Label Signal Word “Keep Out of Reach
on Front Panel Minimum Type Size of Children”
in Square Inches All Capitals Minimum Type Size
5 and under 6 poTht 6 point
above 5 to 10 10 point 6 point
above 10 to 15 12 point 8 point
above 15 to 30 14 point 10 point
over 30 18 point 12 point
Item 7A. CHILD HAZARD WARNING STATEMENT - The statement
“Keep Out of Reach of Children” must be located on the front
panel above the signal word except where contact with children
during distribution or use is unlUcely. See Appendix IV—l.
[ 40 CFR 162.l0(h)(1)(iifl
Item 7B. SIGNAL WORD - The signal word (DANGER, WARNING,
or CAUTION) is required on the front panel immediately below
the child hazard warning statement. See Appendix IV—l.
[ 40 CFR 162.10 (h)(l)(i)3
Item 7C. SKULL & CROSSBONES AND WORD “POISON” - On products
assigned a toxicity Category I on the basis of oral, dermal,
or inhalation toxicity, the word “Poison” shall appear on the
label in red on a background of distinctly contrasting color and
the skull and crossbones shall appear in immediate proximity to
the word POISON. See Appendix tV—i. 40 CFR l62.l0(h)(1)(i)]
Item 7D. STATEMENT OF PRACTICAL TREATMENT - A statement
of practical treatment (first aid or other) shall appear on
the label of pesticide products in toxicity Categories I,
II, and III. See Appendix tV—i. [ 40 CFR 162.10(h)(1)(iii)J
62
-------
Item 7E. REFERRAL STATEMENT - The statement “See Side
(or Back)- Panel for Additional Precautionary Statements” is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
See Appendix IV—l. [ 40 CFR 162.l0(h)(l)(iii)J
Item 8. SIDE/BACK PANEL PRECAUTIONARY LABELING - The
precautionary statements listed below must appear together
on the label under the heading “PRECAUTIONARY STATEMENTS.”
The preferred location is at the top of the side or back
panel preceding the directions for use, and it is preferred
that these statements be surrounded by a block outline. Each
of the three hazard warning statements must be headed by the
appropriate hazard title. See Appendix ri—i. [ 40 CFR 162.10
(h)(2)J .
Item 8A. HAZARD TO HUMANS AND DOMESTIC ANIMALS - Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route(s) of exposure and the precautions to be taken to avoid
accident, injury or damage. See Appendix IV—l. [ ‘40 CFR 162.10
(h)(2)(i)]
Item 8B. ENVIRONMENTAL HAZARD -Where a hazard exists to
non—target organisms excluding humans and dom stic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, injury, or damage. See Appendix IV—l. [ 40 CFR
162.l0(h)(2)(ii)
Item 8C. PHYSICAL OR CHEMICAL HAZARD
1. Flammability statement . Precautionar ’ statements relatIng
to flammability of a product are required to appear on the
label if it meets the criteria in Appendix IV-3. The require-
ment is based on the results of the flashpoint determinations
and flame extension tests required to be submitted for all
products. These statements are to be located in the side/back
panel precautionary statements section, preceded by the
heading “Physical/Chemical Hazards.” Note tnat no slgnal
word is used in conjunction with the flammability statements.
2. Criteria for declaration of non—flammability . The
following criteria will be used to determine if a product
is non—flammable:
a. A “non—flammable gas” is a gas (or mixture of gases)
that will not ignite when a lighted match is placed
against the open cylinder valve.
b. A “non—flammable liquid” is one having a flashpoint
greater than 350°? (177°C).
63
-------
c. A “non—flammable aerosol” is one which meets the
following criteria:
i. The flame extension is zero inches;
ii. There is no flashback; and
iii. The flashpoint of the non—volatile liquid
component is greater than 350° ? (177°C).
3. Declaration of non—flammability . Products which
meet the criteria for non—flammability specified
above may bear the notation “non—flammable” or “non-
flammable (gas, liquid, etc.)” on the label. It may
appear as a substatement to the ingredients statement,
or on a back or side panel, but shall not be highlighted
or emphasized (as with an inordinately large type
size) in any way that may detract from precaution.
L. Other physical/chemical hazard statements . When
chemistry data demonstrate hazards or a physical or
chemical nature other than flammability, appropriate
statements of hazard will be prescribed. Such statements
may address hazards of explo lvity, oxidizing or reducing
capability, or mixing with other substances to produce
toxic fumes’.
Item 9A . RESTRICTED USE CLASSIFICATION - FIFRA sec. 3(d)
requires that all pesticide formulations/uses be classified
for either general or restricted use. Products classified
for restricted use may be limited to use by certified applicators
or persons under their direct supervision (or may be subject
to other restrictions that may be imposed by regulation)
In the Registration Standard, the Agency has (1) indicated
certain formulations/uses are to be restricted (Section I
indicates why the product has been classified for restricted
use); or (2) reserved any classification decision until
appropriate data are submitted.
The Regulatory Position and Rationale states whether
products containing this active ingredient are classified
for restricted use. If they are restricted the draft label(s)
submitted to the Agency as part of your application must
reflect this determination (see below).
If you do not believe that your product should be classified
for restricted use, you must submit any information and
rationale with your application for reregistration. During
the Agency’s review of your application, your proposed classi-
fication determination will be evaluated in accordance with
the provisions of L Q CFR 162.11(c). You will be notified of
the Agency’s classification decision.
6
-------
Classification Labeling Requirements
If Section I of this Guidance Document indicates that
your product has been classified for restricted use, the
following label requirements apply:
1. Front panel statement of restricted use classification.
a. The statement “Restricted Jse Pesticide’ t must
appear at the top of the front panel of the label.
The statement must be set in type of the aame
minimum size as required for human hazard signal
word (see table in kO CPR 162..1O(h)(l)(iv)
b. Directly below this statement on the front panel,
a summary statement of the terms of restriction must
appear (including the reasons for restriction if
specified in Section I). If use Is restricted to
certified applicators, the following statement is
required: “For retail sale to and use only by
Certified Applicators or persons under their direct
supervision and only for those uses covered by the
Certified Applicator’s Cer ification. ”
2. Some but not all uses restricted. If the Regulatory
Positior and Rationale states that some usee are classified
for restricted use, and some are unclassified, several courses
of action are available:
a. You may label the product for Restricted use.
If you do so, you may include on the label uses that
are unrestricted, but you may not distinguish them
on the label as being unrestricted.
b. You may delete all restricted uses from your
label and submit draft labeling bearing only unrestricted
uses.
c. You may “split” your registration, i.e., register
twc -oarate products with identical formulations, one
bedriug only unrestricted uses, and the other bearing
restricted uses. To do so, submit two applications for
reregistration, each containing all forms and necessary
labels. Both applications should be submitted simul-
taneously. Note that the products will be assigned
separate registration numbers.
65
-------
Item 98 [ There is no Item 98].
Item 90. MISUSE STATEMENT — All products must bear the
misuse statement, “It is a violation of Federal law to use
this product in a manner inconsistent with its labeling.”
This statement appears at the beginning of the directions
for use, directly beneath the heading of that section.
Item bA. REENTRY STATEMENT - It a reentry interval
has been established by the Agency, it must be included on
the label. Additional worker protection statements may be
required in accordance with PR Notice 83—2, March 29, 1983.
Item lOB [ There is no Item 108].
Item 1CC. STORAGE AND DISPOSAL BLOCK — All labels are
required to bear storage and disposal statements. These
statements are developed for specific containers, sizes, and
chemical content. These instructions must be grouped and
appear under the heading “Storage and Disposal” in the directions
for use. This heading must be set in the same type sizes as
required for the child hazard warning. Refer to Appendix
IV-Z to determine the disposal instructions appropriate for
your products.
Item 1OD. DIRECTIONS FOR USE — Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide. When followed, directions must be adequate to
protect the public from fraud and from personal injury and to
prevent unreasonable adverse effects on the environment. See
Appendix IV—l. L O CFR 162.10]
B. Collateral Labeling
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, or other written or graphic printed matter which is
referred to on the label or which is to accompany the product
are termed collateral labeling. Such labeling may not be
claims or representations that differ in substance from
those accepted in connection with registration of the product
It should be made part of the response to this notice and
submitted for review.
66
-------
V. INSTRUCTIONS FOR SUBMISSION
A. For Manufacturing Products (MP) containing (name of
pesticide) as an active ingredient .
1. Within 90 days from receipt of this document, you must
submit to the Product Manager in the Registration Division at
the address given at the end of this section the “PIFRA Section
3(c)(2)(B) Summary Sheet” EPA Form 8580—1. Refer to Appendix
11—3 with appropriate attachments.
If on the Summary Sheet, you commit to develop the data,
request a minor chemical exemption, present arguments that a
data requirement is not applicable, or submit protocols or modified
protocols for Agency review, you must also submit a copy of the
Summary Sheet (and any supporting information) to the Office of
Compliance Monitoring, which will be monitoring the data generated
in response to this notice. This information should be submitted
to the Office of Compliance Monitoring at the address given at
the end of this section. (Actual studies are not to be submitted.)
2. Within 6 months from receipt of this document you must
submit to the Product Manager on theRegistration Division:
a. Confidential Statement of Formula, EPA Form 8570—LI.
b. Product Specific Data Report, EPA Form 8580— I
(Appendix 111—1).
c. Two copies of any required product—specific data.
d. Two copies of draft labeling, including the label and
associated brochures. If current labeling conforms to the
requirements of this guidance document and the results of
the short—term data, you may submit such labeling. End use
product labeling must comply specifically with the instructions
in Section I (Regulatory Position and Rationale) of t . .s
guidance document. The labeling should be either ty written
text on 8—1/2 X 11 inch paper or a mockup of the labeling
suitable for storage in 8_i ) x 11 inch files. The cr”ift
label must indicate the ir .....ed colors of the fina. abel,
clear indication of the front panel label, and the intended
type sizes of the text.
e. Evidence of compliance with data support r- q irements
of FIFRA sec. 3(c)(l)(D). Refer to 4 O CFR 152.80—’5’.99
for latest requirements.
3. Within the times set forth in Table A , you must submit
to the Registration Division all generic data, unless you are
eligible for the formulator’s exemption. If for any reason any
test is delayed or aborted so that the agreed schedule cannot be
met, notify the Product Manager and the Office of Compliance
Monitoring.
67
-------
B. For Manufacturing Use Products containing diflubenzuron
. in combination with other active ingredients
1. Within 90 days from receipt of this document, you must
submit the ‘ 1 B I?RA Section 3(c)(2)(B) Summary Sheet,” EPA Form
8580—1. Refer to Appendix 11—3 with appropriate attachments.
If on the Summary Sheet, you commit to develop the data,
request a minor chemical exemption, present arguments that a data
requirement is not applicable, or submit protocols or modified
protocols for Agency review, you must also submit a copy of the
Summary Sheet (and any supporting information) to the Office of
Compliance Monitoring, which will be monitoring the data generated
in response to this notice. This information should be submitted
to the Office of Compliance Monitoring at the address given at
the end of this section. (Actual studies are not to be submitted.)
2. Within the times set forth in Table A , you must submit
to the Registration Division all generic data, unless you are
eligible for the formulator’s exemption. If for any reason any
test is delayed or aborted so that the agreed schedule cannot be
met, notify the Product Manager and the Office of Compliance
Monitoring.
C. For End Use Products containing diflubenzuron alone
or in combination with other .active ingredients :
1. Within 90 days from receipt of this document, you must
submit the “FIPRA Section 3(c)(2)(E) Summary Sheet,” EPA Form
8580—1. Refer to Appendix 11—3 with appropriate attachments.
If on the Summary Sheet, you commit to develop the data,
request a minor chemical exemption, present arguments that a
data requirement is not applicable, or submit protocols or modified
protocols for Agency review, you must also submit a copy of the
Summary Sheet (and any supporting information) to the Office of
Compliance Monitoring, which will be monitoring th’. data generated
in response to this notice. This 1 ‘ormation sho ’d be submitted
to the Office of Compliance Monitoring at the address given at
the end of this section. (Actual studies are not o be submitted.)
2. Within 6 months from receipt of this document you must
submit:
a. Confidential Statement of Formula, EP Form 8570— 4.
b. Product-Specific Data Report, EPA Form 8580— 1
(Appendix 111—1).
c. Two copies of any required product—specific data.
(Refer to Table C).
68
-------
d. Two copies of draft labeling, including the label and
associated brochures. If current labeling conforms to the
requirements of this guidance document and the results of
the short-term data, you may submit such labeling. End use
product labeling must comply specifically with the instructions
in Section I (Regulatory Position and ationale) of this
guidance document. Labeling should be either typewritten
text on 8 1/2 x 11 inch paper or a mockup of the labeling
suitable for storage in 8 1/2 inch files. The draft label
must indicate the intended colors of the final label, clear
indication of the front panel label, and the intended type
sizes of the text.
e. Evidence of compliance with data support requirements
f PIPRA sec. 3(c)(1)(D). Refer to L 0 CFR 152.80—152.99
for latest requirements.
3. Within the time frames set forth in Table A , submit all
generic data, unless you are eligible for the formulator’s
exemption.
D. For intrastate products containing diflubenzuron
either as the sole active ingredient or in combination
with other active ingredients
These products are being called in for full Federal
registration. Producers of these products are being sent
a letter instructing them how to submit an application for
registration.
E. Applications and other required information should be
submitted to the following address:
Timothy Gardner
Product Manager Team 17
Registration Division (TS—767C)
Offire of Pesticide Programs
Environmental ?rotection Agency
01 M St., SW.
Washington, D.C. 201460
Phone No. (703)
The address for submission to the Office of Compliance Monitoring
is:
Laboratory Data Integrity Program
Office of Compliance Monitoring (EN—3142)
Environmental Protection Agency
L 0l M St., SW.
Washington, D.C. 20L 60
69
-------
Appendi.x 11-1
Guide to Use of This Bibliography
1. CONTENT OF BIBLIOGRAPHY. This bibliography contains
citations of all studies considered relevant by EPA in
arriving at the positions and conclusions stated elsewhere
in the Standard. Primary sources for studies in this
bibliography have been the body of’ data submitted to EPA
and its predecessor agencies in support of past regulatory
decisions. Selections from other sources including the
published literature, in those instances where they have
been considered, will be included.
2. UNITS OF ENTRY. The unit of entry in this bibliography
is called a “study.” In the case of published materials,
this corresponds closely to an article. In the case of
unpublished materials submitted to the Agency, the Age icy
has sought to identify documents at a level parallel to
the published article from within the typically larger
volu.mes in which they were submitted. The resulting
“studies” generally have a distinct title (or at least a
single subject), can stand alone for purposes of review,
and can be described with a conventional bibliographic
citation. The Agency has attempted also o unite basic
documents and commentaries upon them, treating them as a
single study.
3. IDENTIFICATION OF ENTRIES. The entries in this bibliography
are sorted numerically by “Master Record Identifier,” or
MRID, number. This number is unique to the citation, and
should be used at any time specific reference is required.
It is not related to the six—digit “Accession Number”
which has been used to identify volumes of submitted
studies; see paragraph 14(d)( 1 ) below for a further explana-
tion. In a few cases, entries add..d to the bibliograph ,
late in e review may be precede’ by a nine—character
temporary identifier. These entries are listed after
all MRID entries. This temporar identifier number is
also to be used whenever specifi “ef’erence is r eeded.
L$ FORM OF ENTRY. In addition to the Master Record Identifier
(MRID), each entry consists of e citation containing
standard elements followed, in the case of material
submitted to EPA, by a descriptici of the earliest known
submission. Bibliographic conve .tion3 used reflect the
standards of the American National Standards Institute
(ANSI), expanded to provide for certain special needs.
70
-------
Appendix 11—1 (continued)
a. Author. Whenever the Agency could confidently identify
one, the Agency has chosen to show a personal author.
When no individual was identified, the Agency has
shown an identifiable laboratory or testing facility
as author. As a last resort, the Agency has shown
the first submitter as author.
b. Document Date. When the date appears as four digits
with no question marks, the Agency took it directly
from the document. When a four—digit date is followed
by a question mark, the bibliographer deduced the
date from evidence in the document. When the date
appears as (19?’?), the Agency was unable to determine
or estimate the date of the document.
c. Title. In some cases, it has been necessary for
Agency bibliographers to create or enhance a document
title. Any such editorial insertions are contained
between square brackets.
d. Trailing Parentheses. For studies submitted to the
Agency in the past, the trailing parentheses include
(in addition to any se1f—ex i1anatory text) the fol-
lowing elements describing rhe earliest known submission:
(1) Submission Date. Thedate of the earliest known
submission appears immediately following the word
“received. u
(2) Administrative Number. The next element,
immediately following the word “under,” is the
registration number, experimental use permit
number, petition number, or other administrative
number associated with the earliest known submission.
(3) Submitter. The third element is the submitter,
following the phra: “submitted by.” When
authorship is def .ulted to the submitter, this
element is omitted.
(4) Volume Identific .ton (Accession Numbers). The
final element in t e trailing parentheses
identifies the EPA accession number of the volume
in which the original submission of the study
appears. The six—digit accession number follows
the symbol “CDL ,” standing for “Company Data
Library.’ This accession number is in turn
followed by an alphabetic suffix which shows the
relative position of the study within the volume.
For example, within accession number 123456, the
first study would be l23 1 456—A; the second, 123456—
B; the 26th, 123456—Z; and the 27th, 123456—AA.
71
-------
Appendix 11-2
OFFICE OP PESTIC E P GRA tS
R ISThP 1 TI0N STANDARD ThLTOGRAF Y
Citations Considered to be Part of the Data Base Supportir
Registrations Under the Di!lubenzuron Standard
CITATION
00010856 LeBlanc, G. (1975) The Chronic Toxicity of Altosid CR), ‘fli—60140,
end R—20458 to Daphnia magna:. (Unpublished study received Feb
8, 1977 under 209514—1; prepared by Efl& , Bionomics, su itted by
Zoecon Corp., Palo Alto, Calif.; CDL:231488—I)
00028435 Schaefer, C.H.; Dupras, E.P., Jr. (1977) Residues of Diflubenzuron
[ 1—( J4—Chloropheriyl) —3— (2,6 difluorobenzoyl ) -urea in Pasture
Soil, Vegetation and Water following Aerial Applications. (Un-
published study received Jul 31, 1978 under 148—1259; preparea
by Univ. of California, Mosquito Control Research Laboratory,
su itted by Thompson-Hayward Ch ica]. Co., Kansas City, Kans.;
CDL: 234514—C)
00029737 Miller, R.W.; Corley, C.; Hill, K.R. (19??) Feeding 6040 to
chickens: Effect on larval house flies in manure arid deter ina-
tion of residues in eggs. Journal of Economic Entomology 68(2):
181—182. (Also in unpublished su ission received Jul 31, 1978
under 148—1259; su itted by Thompson—Hayward Chemical Co.,
Kansas City, Kans.; CDL:2345JJ1-B)
00029739 De Wilde, P.C.; Buisn n, P. (1976) Residues of Diflubenzuron in
Poultry Tissues: Report No. 56630/95/76. (Unpublished study re-
ceived Jul 31, 1978 under 148—1259; prepared by Philips—Duphar
B.V., su itted by Thompson-Hayward Ch ica1 Co., Kansas City,
Kan.s.; CDL:234514—E)
00029741 Escobar, E.N.; Miller, R. (1977) Sheep Feeding Study: Residue Test
No. 1184. (Unpublished study received Jul 31, 1978 under 148—
1259; prepared in cooperation with Univ. of Maryland, A&lcu.1-
tural Experiment Station, su itted by Thompson—Ha ”riard Ch ica1
Co., Kansas City, Kans.; CDL:234514—G)
00029742 Escobar, E.N.; Miller, R. (1977) Swine Feeding Study: Residue Test
No. 1494. (Uruolished study received Jul 31, 1978 under 148—
1259; prepared i’t cooperation with Univ. of Maryland, Agricu.1-
tural Experime. it Station, su itted by Thompson—hayward Chemical
Co., Kansas City, Karis.; CDL:23’4514—I)
00038212 Steelman, C.D.; Faxlow, J.E.; Breaud, T.P.; et al. (1975) Effects
of Insect Develc ient Inhibiting Ch ica.ls on Psorophora
co1 biae (Dyar and Knab) and Non—target Aquatic Insect Spe-
cies in Rice Fields. (Unpublished study received Feb 10, 1976
under 6G174 1 4; prepared by Louisiana State Univ., Depts. of
Entomology and Experimental Statistics, su itted by Thompson-
Hayward Chemical Co., Kansas City, Kans.; CDL:0914969—G)
72
-------
OFFICE OF PESTIC E PROGRAMS
R ISTRATION STANDARD BIBLIOGRAF ’
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Diflubenzuron Standard
CIT .4 ’ION
00038213 Booth, G.M. (1975) The Impact of Dim.tliri W—25 on Non-target I.nver—
tebrates in Ponds Located in Salt Lake County, Utah. Final
rept. (Unpublished stud.y received Feb 10, 1976 under 6G171414;
prepared by Brigham Young Univ., Dept. of Zoology 1 su itted by
Thc pson—Haywa.rd Chemical Co.; Kansas City, Kans.; CDL:09 1 4965-H)
00038268 Sleck, R.F. (1976) Residues of ¶1 i 60140 Equivalents in Cotton and
Rotational Crops following Foliar Application. (Unpublished
study including letter dated Jan 29, 1976 fr R.F. Sieck to
Donald Nye, received Feb 10, 1976 under 6G174’4; prepared by
Analytical Deve1op ent rp, su .ttted by Th pson-Hayward
Chemical Co., Kansas City, Kans.; CDL:09 1 4970—D)
000382714 Di Prima, S.J. (1975) Deter ination of Th—60 40 (N—( 1 4—Chloropheri-
yl)amino carbonyl—2,6—d.tl’luorobenzamide) in Forest Foliage,
Forest Litter, 501.1 and Sediment. Method rio. 2 dated Oct 10,
1975. (Unpublished study received Feb 10, 1976 under 6G17’4’4;
su nitted by Th psa —Hayward--Chemical Co., Kansas City, Kans.;
CDL: 0914971—C)
00038611 Marine Research Institute (1973) Oyster Bioassays: 96—Hour EC5O
with Fertilized Eggs, Larva and Post-Juveniles. (Unpublished
study received Feb 10, 1976 under 6G17414; su itted by Thompson—
Hayward Chemical Co., Kansas City, Kans.; CDL:09149714—C)
00038612 Bionom .ics— , Incorporated (1975) The Acute arid Subcb.ronic
Toxicity of R—20 1 458, Altosid arid Th—60140 to the Grass Shrimp,
Palaemonetes puglio:. Final rept. (Unpublished study re-
ceived Feb 10, 1976 under 6G17144; su .itted by Th pson—Haywa-rc
Chemical Co., Kansas City, Kans.; CDL:091497 4—D)
00038613 Fink, R.; P t’ocelli, S.R. (1973) Final Report: Eight-Day Dietary
LC5O—MaJ .iard Ducks: Pro ect No. 553—118. (Unpublished study
receive -i Feb 10, 1976 under 6G171414; prepared by EnvirormentaJ.
Sciences Corp., su itted by Thompson-Hayward Chemical Co.,
Kansas City, Karis.; CDL:09 1 49714—E)
000386114 Alsager, D.F.; Cook, D.A. (1975) Acute Oral Toxicity Studies
(LD5O) of 60140 Insecticide to Red Winged Blackbirds
(Agelalus phoeniceus) CBSC No. —112—75. (Unpublished
study r ceived Feb 10, 1976 under 6Gl714 1 4; prepared by Canadian
Blo-Scientific Consultants, Ltd. and Univ. of Alberta, Dept. of
Pbar acology, su itted by Thompson-Hayward Chemical Co., Kansas
City, Kans.; CDL:09149714—G)
73
-------
OFFICE OF P TICIDE PRCGRAL tS
LS ATION STANDARD BIELICGRAP
Citations Considered to be Part of the Data Base Supporting
Re .strations Under the Diflubenzuron Standard
CITATION
00038706 Chesterman, H.; Heywood, R.; Barker, M.H.; et a].. (1974) Du 112307:
Toxicity in Repeated Dietary A 1nistration to Beagle Dogs (Re-
peated A inistration for 13 Weeks): PDR.169/7 1 4157. (Unpub—
lished study received Feb 10, 1976 under 6G17L414; prepared by
Huntingdcn Research Centre, su itted by Thompson-Hayward Chem-
ical Co., Kansas City, Kans.; CDL:094963—G)
00038708 De Lange, N.; Overmars, H.; Willerns, A.G.M.; et a].. (1975) D1!lu—
benzuron (PH 60—40): Balance Studies in the Rat, and IdentU’lca—
tion of Urinary Metabolites: Report No. 56654/22/75. (Unpub-
lished study received Feb 10, 1976 under 6G17’414; prepared by
Philips-Duphar, B.V., su itted by Thompson-Hayward Chemical
Co., Kansas City, Karis.; CDL:09 1 496’1—B)
00038715 Davies, R.E.; Hallida .y, J.C.; Street, A.E.; et al. (1975) Effect
of Repeated Applications of Du 112307 to the Skin of Rabbits
for Three Weeks: PDRJ.46/73845: (Unpublished study received
Feb 10, 1976 under 6G174 4; pr pared by Huntingdon Research Cen-
tre, su itted by Thompson-Hayward Chemical Co., Kansas City,
Kans.; CDL:ô9 4964—J)
00039080 Fink, IL (1973) Final Report: Ei bt-Day Dietary LC5O—Bcbwhite
Quail: Project No. 553—117. (Unpublished study received Apr 7,
1976 under 148—1259; prepared by Enviror ental Sciences Corp.,
su .ttted by Thompson—Hayward Ch 1caJ. Co., Kansas City, Kans.;
CDL: 096227—F)
00039088 Union Carbide Corporation (1976) Acute Toxicity of Dimilin W—25 to
Anodonta sp.; Mercenaria mercenaria; rJca pugiJ.ator; Car-
cinu.s .enas. (Unpublished study received Apr 7, 1976 under
14?-1259; su itted by Thompson—Hayward Chemical Co., Kansas
Cicj, Kans.; CDL:096227—P)
00039090 Unior. Carbide Corporation (1976) The E.ffect of the fosqu.ito Lar-
vi..ade Dirnilin on the Freshwater Enviror ent of Three Test Ponds
in Texas. (Unpublished study received Apr 7, 1976 under 1’48—
1259; su itted by Thompson-Hayward Chemical Co., Kansas City,
Kans.; CDL:096228—A)
00039091 Union Carbide Corporation (1976) The Effect of the Mosquito Lar—
i .cide Di.miliri on the Freshwater Envirorment of Three Test Ponds
in Arkansas. (Unpublished study received Apr 7, 1976 under
148—1259; su itted by Thompson—Hayward Chemical Co., Kansas
City, Kans.; CDL:096228—3)
7i4
-------
OFFICE OF PESTICIDE PROGRAMS
R IS ATION STANDARD B LIOGRAP
Citations Considered to be Part of the Data 3ase Supporting
Registrations Under the Diflubenzuron Standard
CITATION
00039092 Union Carbide Corporation (1976) The Effect of the Mosquito Lar—
vicide D1 rni 1th on the Freshwater Envirorent of Three Test Ponds
in North Carolina. (Unpublished study received Apr 7, 1976 un-
der 1148—1259; su itted by Th pson—Hayward Chemical Co., Kansas
City, Kans.; CDL:096228—C)
00039095 Union Carbide Corporation (1976) The Erfect of the Mosquito Lar-
vicide Dimilin on the Brac d.sh Water viror ent of Three Test
Canals in Louisiana. (Unpublished study received Apr 7, 1976
under 148—1259; su .itted by Tbpson—Hayward Chemica]. Co., Kan-
sas City, Kans.; CDL:096228—F)
000391481 Ni o, W.B.; De Wilde, P.C. (1975) Degradation of Di .flubenzuron
in Sterile Water at pH 5, 7, 9 and 12: Report No. 56635/32/1975.
(Unpublished study received Feb 10, 1976 under 6G17’1 1 4; pre-
pared by Philips-Duphar, 3.V., su itted by Th pson-Hayward
Chem.ical Co., Kansas City, Kan ; CDL:0914972—J)
000140159 Ivie, G.W. (1975) Metabolism of DIinIlln [ 1—(2,6—Dtfluorobenzoyl—3—
(4—ch .loropheny1)urea by a Lactating Cow, and Pate of the Ma.jor
Metabolite in Rats. (U.S. Agricultural Research Service, Veter-
mary Toxicology and Entomology Research Laboratory, unpuollsned
stud.y; CDL:096220—E)
00040767 Th pson—Hayward Chemical C pariy (1976) Residue Report: Beef,
Poultry Tissues: Residue Test No. 1072. (Unpublished study
received Apr 7, 1976 under 1 8—1259; prepared in cooperation
with Cannon Laboratories, Inc.; CDL:096223—K)
000140770 Di..Prtma, S.J. (1975) DeterminatIon of Th_60140 (N— [ [ (14—chioro—
pheriyl ) amino carbony 1—] 2, 6—di.fluorobenzamide) in Cow Tissues,
Poultry Tissues, Fish, Eggs and Milk. Method no. 3 dated Nov
20, 1C ’. (Unpublished study received Apr 7, 1976 under 1148—
1259’ ared in cooperation with Cannon Laboratories, sub—
mitted by Thcmpson—Hayward Chemical Co., Kansas City, Kans.;
CDL: 096223—N)
0O0L4 8 47 Davies, R.E.; Hallisay, J.C. (1974) Acute Percutaneous Toxicity to
Rabbits of DO 112307 (TechnIcal): Report No. 21711D175173.
(Unpublished study received Feb 10, 1976 under 6G17 l4; prepared
by Huntingdon Research Centre, England, su 1tted by Th pson—
Hayward Chemical Cc., Kansas City, Karis.; CDL:0914962—F)
75
-------
OFFICE OF PESTICIDE PROGRAMS
RECISThATION STANDARD BThLIOGRAP
Citations Considered to be Part of the Data Ease Supporting
Registrations Under the Diflubenzuron Standard
CITATION
000144326 Palmer, A.K., Hill, P.A. (1975) Effect of Du 112307 on Pre iancy
of the Rat: P l92/74978. (Unpublished study received Feb 10,
1976 under 6G17 1 44; prepared by Huntingdon Research Centre, Eng-
land, su itted by Th psori—Eaywand Chemical Co., Kansas City,
Kans.; CDL:0914965—C)
00044327 Palmer, A.K.; Hill, P.A. (1975) Effect of Du 112307 on Pre ancy
of the New Zealand White Rabbit: PDR 193/74937. (Unpublished
study received Feb 10, 1976 under 6G1744; prepared by Hunting—
don Research Centre, England, su itted by Th pscn—Haywand
Chemical Co., Kansas City, Kans.; CDL:094965—D)
000414329 Hunter, 3.; Colley, J.; Street, A.E.; et al. (1975?) Effects of Cu
112307 in Dietary A in1stration to Rats for 10 4 Weeks. (Un-
published study received Feb 10, 1976 under 6G1744; prepared
by Huntingdon Research Centre, England, su itted by Thompson-
Hayward Chemical Co., Kansas City, Kanz.; CDL;094966—A; 0914967;
094968) —
00044330 Palmer, A.K.; Hill, P.A. (19??) Effect of Du 112307 on Reproduc-
tive Function of ?vkltiple Generations in the Rat: PDR173/7595 1 4.
(Unpublished study received Feb 10, 1976 under 601744; preparec
by Huntingdon Research Centre, England, su itted by Th pson-
Hayward Chemical Co., Kansas City, Kari.s.; CDL: 094968—A)
00056150 Marshall, B.L.; Hieb, B.L. (1973) 96—Hour LC5O Salmo gairdneri,
Lep is macrochiriz and Funculus heteroclitus. (UnpublIshed
study receIved Apr 5, 1974 under 148—1170; prepared by Marine
Research Institute, su itted by Thompson-Hayward Chemical Co.,
Kansas City, Kans.; CDL:224671-O)
00056035 Pitcher, F.G. (1973) 60140: luegil1 (Lepom.is macrochirus).
(U.S. Agricultural Researct Service, Pesticides Regulation Div.,
Animal Biology Laboratory, unpublished study; ( 132525—A)
000603614 Bryant, H. (1976) Activity of —60140 in the Ames Salmonella tg—
phimurium Mutagenesis Assay. (Unpublished study received July
31, 1978 under 148—1259; su itted by Thompson—Hayward Chemical
Co., Kansas City, Kans.. CDL:23 45 13—F)
76
-------
OFFICE OP PESTIC E PRC RAMS
R ISTRATION STANDARD BIBLI0GRAP}
Citations Considered to be Part of the Data Ease Supportiri
Registrations Under the Dfflubenzu.ron Standard
CITATION
00060376 Reinert, H.K.; Parke, G.S.E. (1975) Report: Static 96 Hour Toxicity
Study of Th paon Hayward Chemical Canpany Sample Th 60140 in
Fathead Minnows: Laboratory No. 5E-6095. (Unpublished study re-
ceived Ju.]. 31, 1978 under 148—1259; prepared by Cannon Labora-
tories, Inc., submitted by Th pscn—Hayward Chemical Cc., Kansas
City, Kan3.; CDL:23 1 4513—S)
00060380 Reirtert, H.K.; Parke, G.S.E. (1976) Report: Static 96—Hour Toxicity
Study of DtrnlJi.n 1.0% Granular in BluegilJ. Sunfish and Rainbow
Trout: Laboratory No. 6E—2035. (Unpublished study received Jul
31, 1978 under 148—1259; prepared by Cannon Laboratories, Inc.,
suh’i1 tted by Tb pson—Hayward Chemical Co., Kansas City, Kans.;
CDL: 2314513—W)
00060381 Roberts, S.; Parke, G.S.E. (1976) Report: 8—Day Dietary LC5O Study
of D rni1 r 1G: Bobwhite Quail and Mallard Ducks: Laboratory
No. 6E—2036. (Unpublished study received Jul 31, 1978 under
1148—1259; prepared by Car ia Laboratories, Inc., submitted by
Thc npson—Haywa.rd Chemical Co.7Kansas City, Kans.; CDL:234513-X)
00060383 Miller, R.W.; Corley, C.; Shufelt, S.R. (1976) Effects of feeding
‘ —6040 to two breeds of chickens. Journal of Econcmic to-
ology 69(6):741—743. (Also in unpublished submission received
Jul 31, 1978 under 148—1259; submitted by Th pson—Hayward Chem-
ical Co., Kansas City, Kanz.; CDL:234513—Z)
000603814 Fraser, W.D.; Fell, I.E. (1977) The Acute Toxicity of Du 112307
(D1-m i1iri 25% P) to the C on Carp (Cyprinus carplo) and
the Rainbow Trout (Sa].mo gairdrierl): Report No. 556145/1/77.
(Unpublished study received Jul 31, 1978 under 1148—1259; pre-
pared by Huntingdon Research Centre, England, submitted by
Th pson-Hayward Ch ’ icaJ . Cc., Kansas City, Kans.; CDL:
2314 513—AB)
000614922 Opdycke, J.C.; Millei, R.W.; Merizer, R.E. (1976) Metabolism and
Pate of N— ( 4—Chio ’crhenyl ) -N’ -(2, 6—difluorobenzoyl ) urea in
Chickens and Swine. (Unpublished paper presented at the Fif-
teenth Annual Met ting of the Society of Toxicology; Mar 15,
1976, Atlanta, Ga.. unpublished study received Dec 23, 1976 un-
der 148—1258; prepared by Univ. of Maryland, Dept. of Ent ol-
ogy, submitted ty Th pson-Hayward Chemical Co., Kansas City,
Kans.; CDL: 095655—B)
77
-------
OFFICE OF PESTIC E PROGRAMS
R IS TION STANDARD BTRLIOG?AP
Citations Considered to be Part of the Data Ease Supporting
Registrations Under the Diflubenzuron Standard
CIT I0N
00069870 MacGregor, J.T.; Gould, D.H. (1977) Results of Test1n Difluben—
zuron in the Ames Salmonella/Maalian Microsane Mutagenicity
Test and in the Micronucleus Test in Mice. (U.S. A icultura1
Research Service, Western Regional Research Laboratory, Toxicol—
ogy and Eiologica.l Evaluation Research Unit; unpublished study;
CDL: 096300—G)
00069871 Mitchell, A.D.; Sterling, G.P.; Taji.ri, D.T. (1977) ResuJ.ts of
Testing USDA C pound WRRC-153-10-PJX, with and without Metabol-
ic Activation, in the Mouse Lymphoma ‘ ( +1- [ to] TK -/-t Muta-
genesis Syst : SRI Project LSU—5826. Phase I rept. (Stanford
Research Institute for U.S. A icultural Research Service,
Western Regional Research Laboratory; unpublished study; CDL:
096300—H)
00O7002 Koo nan, T.S.M.; Off ringa, 0.R. (1977) Acute Oral Toxicity Study
with Cu 112307 (Technical) in Mice: Report No. 56615/4/77.
(Unpublished study received J 22, 1977 under 6F1773; prepared
by Ph.ilips—Duphar, B.V., Netherlands, su nitted by Th ipson—
Hayward Chemical Co., Kansas City, Kans.; CDL:096166—K)
00070027 Koopinan, T.S.M.; Offringa, O.R. (1977) Acute Dermal Toxicity Study
with Cu 112307 (Technical) in Rats: Report No. 566 45/7/77.
(Unpublished study received Jun 22, 1977 under 6P1773; prepared
by Philips-Duphar, B.V., Netherlands, su 1tted by Thc pson—
Hayward Ch ic.a]. Cc. Kansas City, Karis.; CDL:096167-A)
00070181 Di Prima, S.J. (1976) Hydrolytic Consistency of Dtflubenzuron arid
L —Chlorophenylurea with 1.2N Hydrochloric Acid: Research Report
No. SFt—3. (Unpublished study received Dec 23, 1976 under 1148—
1258; siiri1 t d by Th pson—Haywar’d Ch ical Co., Kansas City,
Kans.; CDL:095668—A)
00070183 Di Prima, S.J. (1976) Specificity of T pson—Ha wa.rd Analytical
Meth No. 20 for the Deter ination of Diflubenzuron Residues
in Cotton See 1 and Process Fractions: Research Report No. SR-5.
(Unpublished study received Dec 23, 1976 under 1118—1258; sub-
mitted by Tb pson-Hayward Cbemi.ca.l Cc., Kansas City, Karls.;
CDL: 095668—D)
000701814 Di Prima, S.c. (1975) Specificity Study of T rmpson—Hayward Ana-
lytical Meth No. 7 for the Determination of Diflubenzuron
Residues in Cotton Foliage, Seed arid Process Fractions: Re-
search Report No. SR—8. (Unpublished study received Dec 23,
1976 under 1118—1258; su itted by Th pson—Hayward Chemical
Co., Kansas City, Kans.; CDL:095668—E)
78
-------
OFFICE OF PESTICIDE P GRA1 1S
R IS’ A ’I0N STANDARD B1 LIOGRAF}
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Dtflubenzuron Standard
CITATION
00070185 n.ith, K.S. (1976) T.H.6O 4O Tissue Residue and Metabolism Study
in Dairy Cows: Laboratory No. 5E-7372. (Unpublished study
received Dec 23, 1976 i.mder 148—1258; prepared by Cannon Lab-
oratories, Inc., su itted by Th pson-Mayward Ch .ical Co.,
Kansas City, Kans.; CDL:09566&-F).
00070186 nith, K. (1976) T.H.6040: Tissue Residue and Metabolism Study
in Poultry: Laboratory No. 5E—7372. (Unpublished study re-
ceived Dec 23, 1976 under 148—1258; prepared by Cannon Lab—
oratories, Inc., su itted by ThrAnpson-Hayward Chemical Co.,
Kansas City, Kans.; CDL:095668—G)
00070187 Di Prima, S.J. (1976) Specificity Study of Th pson-Hayward An-
alyticaJ . Method No. 3 for the Determination of Diflubenzuron
Residues in Animal Tissues: Research Report No. SR —4. (Unpub-
lished study received Dec 23, .1976 under 148—1258; su itted
by Th pson- iayward Chemical Co., Kansas City, Kans.; CDL:
095668—H)
00070700 D l. Prima, 5.3. (1976) Efficiency of Derivatization of 4—Chioro—
aniline with Heptafluorobutyric Anhydride: Research Report
No. SFL—2. (Unpublished stud.y received Dec 23, 1976 under 148—
1258; su itted by Th pson-Hayward Chemical Co., Kansas City.
Kanz.; CDL:095668—C)
00071074 U.S. Forest Service, comp. (1975) Evaluation of Dirniliri a aLnst the
Gypsy Moth arid Effects on Non-target Organisms. (Northeastern
Area State & Private Forestry, Expanded Gypsy Moth Research and
Applications Program; unpublished study; CDL;2 1 4 1 4522—A)
00071210 Buclcier, .L; McLeod, B.B.; Kingsbury, P.D. (1975) The Effect
of an Experimental Application of D1ini 1in CR) upon Selected
For it Fauna: Report CC-X-97. (Canada— iviror ent, Forestry
Seri. ce, Chemical Control Research Institute; unpubLished study;
CDL: 016232—K)
00071212 Matthen.1 z, J.C., Jr. (1975) Effects of Dimili_n on Honey Bees.
(New Jersey, Dept. of Agriculture; unpublished study; CDL:
0q6232—M)
00071816 Th .n—Haywar Chemica.l C pany (1981) Non—target Effects. (C —
pi.lation; unpublished study received Apr 30, 1981 under 11 18—
1268; CDL:070050—B)
79
-------
OFFICE OF PESTICIDE PRCGRAMS
R ISTRATI0N STANDARD B LIOGRAP
Citations Considered to be Part of the Data Ease Supporting
Registrations Under the Diflubenzuron Standard
CITATION
00071822 1Q alil, M. (1977) Hydrolytic Cori.sistency of Diflubenzuron and 4-
Chiorophenylurea with 3.6M Hydrochloric Acid: Research Report
No. t—11. (Unpublished study received Apr 30, 1981 under 1148—
1268; su .itted by Tbanpson—Hayward Ch ica.1. Co., Kansas City,
Kans.; CDL;070051—E)
00071823 Q ia.lil, M. (1977) Ti Study for the Hydrolysis of Difluben.zuron
with 3.6M Hydrochloric Acid: Research Report No. SR-15. (Unpub .-
Lished study received Apr 30, 1981 under 1148—1268; su itted by
Th pson—Hayward Ch ica.l Co., Kansas City, Kans.; CDL:070051—I)
00073935 Roberts, S.; Parke, G.S.E. (1976) Acute Oral Toxicity in Bobwhite
Quail C ipound: T H 60140 99.4% Pure (Air M.tJ.J.ed): Laboratory
No. 6E—2430 A. (Unpublished study received Dec 23, 1976 under
1148—1258; prepared by Ca ion Laboratories, Inc., su itted by
Tha pson—Hayward Chemical Co., Kansas City, Kans.; CDL:095663—N)
00073936 Roberts, S.; Parke, G.S.E. (1976) Acute Oral Toxicity in Mallard
Ducks: Laboratory No. 6E-2430 B. (Unpublished study received
Dec 23, 1976 under 148—1258; prepared Cannon Laboratories,
Inc., su itted by Th pson—Hayward Che i.cal Co., Kansas City,
Kans.; CDL:095663—O)
00075521 Rasn, G. (1978) Stability of Dtf’lubenzurcn Residues in Oranges in
Frozen Storage. (Unpublished study received Apr 30, 1981 under
148—1268; su itted by Th pson—Eayward Chem.tcal Co., Kansas
City, Kans.; CDL;070053—B)
00095416 Wan, M.T.X.; Wilson, D.M. (1977) Impact of Insect Growth Regulators
on Selected Non—target Organi s Co-existing with Mosquito
L .rvae: Report No. S 5—PR-77—1. (U.S. Enviror enta1 Protec-
tion Service, Pacific Region, Pollution Abat ent Branch; unpub-
lished study; CDL:234512—U)
00099673 ar1ow, J. (1976) Ecological Impact of Diinilin ... on the Aquatic
Fauna of a Louisiana Coastal Marsh. Doctoral dissertation,
LouisIana State Univ. and Agricultural and Mechanical College,
Dept. of & tcmo1ogy. (Unpublished study received Dec 23, 1976
under 148—1258; su itted by Th pson—Hayward Ch 1caJ. Co.,
Kansas City, KS; CDL:095650—K)
80
-------
OFFICE OF PESTIC E PRCGRAMS
IS ATION STANDARD BThLICGRAP ff
Citations Considered to be Part of the Data Ease Supporting
Registrations Under the Diflubenzuron Standard
ID CIT) ION
00099683 DtPriria, 3. (1976) Determination of Diflubenzuron (‘fli—60 40), N—
CE (l.-chlorophenyl) amino] carbcnyl]—2,6—difluOrobeflzam.lde)
Residues in Cotton Foliage, Seed, and Process Fractions (Meal,
Oil and Hu.Lls) by Gas Chr atograpby: Analytical Method No. 20.
(Unpublished study received Dec 23, 1976 under l 48—l258; sub-
mitted by Thanpson—Hayward Ch .ic a]. Co., Kansas City, KS;
CDL: 095667—3)
000996814 DiPrina, 3. (1975) Determination of i—60140 (N— [ [ ( 1 4—cküorophenyl)
amino] carboriyJ.]—2,6—difluorobenzamide) in Cotton Pol age, Seed
Lint, Oil, Soapstock Meal and Hulls: Analytical Method No. 7.
(Unpublished study received Dec 23, 1976 under lL 8—1258; pre-
pared in cooperation with Cannon Lab, submitted by
Thpson—Hayward Ch ica.l Co., Kansas City, KS; CDL:095667-E)
00099686 DiPrina, S. (1976) Determination of Diflubenzu.ron (Th—60 0, N— [ [ (L —
cb.lorophenyl) amir ] carbonyl —2, 6—difluorobenzam.ide) and 14—
clorophen yhirea Residues in Rotational Crops by Gas Chr na—
tography: Analytical Method No. 12A. (Unpublished study re-
ceived Dec 23, 1976 under 1148—1258; s ibmitted by Th pson—Hay—
ward Ch ica]. Co., Kansas City, KS; CDL:095667-J)
0009969 4 Thc pscn-Hayward Chemical. Co. (1976) Residue Data: [ Dtflubenzuron].
(C pilation; unpublished study received Dec 23, 1976 under 1148—
1258; CDL:095669—A; 095670; 095671; 095672; 095673)
00099719 Booth, G.; Johnson, S.; H an, D.; et a].. (1977) The Effect of
Dtfluberizuron on the Reproduction of Bobwhite Quail. (Unpub-
lished study received Feb 6, 1978 under 1148—1259; prepared by
Brig ian Young Univ., Depts. of Statistics and Zoology and Univ.
of Illinois, School of Life Sciences, submitted by Th pson—
Hayward Chemical Co., Kansas City, KS; CDL :096787—J)
0G099722 Livingston, R.; Koenig, C. Life Cycle Toxicity Tests Con-
cerning the Acute arid Chronic Effects of a Pesticide (Th—60 40)
on the ‘ttichug (Thjndulus heterocli.tus Walba ), and Egg-laying
To .trinow. (Unpublished study received Feb 6, 1978 under 1148-
1259; prepared by Envlrorental Planning & Analysis, submitted
by Tbc npson—Hayward Chemical Co., Kansas City, KS; CDL:096787-M)
00099730 Roberts, S.; Parke, G.; Charles, S. (1977) ReproductIon Study of
Airmiuled Technical Dtf’lubenzuron in Bob iite Quail: Labora-
tory No. 7E-6032. (Unpublished study received Feb 6, 1978
under 1148—1259; prepared by Cannon Laboratories, Inc., sub-
mitted by Th pson—Hayward Che Ical Co., Kansas City, KS; CDL:
096788—J)
81
-------
OFFICE OF PESTIC E PROGRAMS
R ISThATION STANDARD BThLTCGRAP
Citations Considered to be Part of the Data Ea.se Supporting
Registrations Under the Diflubenzuron Standard
CITA ON
0O0997L 3 Robinson, F. (1978) The Effect of Repeated Spray AppLications of
Dtirflin W—25 on Honey Bee Colonies in Cotton Fields. (tinpub-
li hed study received Dec 15, 1978 under 1148— —25; prepared by
Univ. of Florida, Institute of Food and Agricultural Sciences,
Dept. of Ent ology & Ne .tolo r, sulznitted by Thc pson-Mayward
Ch ica.l Co., Kansas City, KS; CDL:097738-C)
00099755 Cannon, G.; Krize, J. (1976) ‘ —6OL 0 Egg to Egg Reproduction Study
in Fathead Minnows: Laboratory No. 5E-60914. (Unpublished study
received Jul 19, 1976 under 1L$8_1262; prepared by Cannon Labora-
tories, Inc., submitted by Tb pson—Hayward Chenical Co., Kansas
City, KS; CDL:096209—I; 225306)
00099762 Johansen, C.; Robinson, W. (1977) Impact of Chem.ica]. Control Ap-
plication.s in the Forest on Beneficial Insects. Progress rept.
IV. (U.S. Forest Service; unpublished study, CDL:096171—G)
00099767 U.S. Agricultural Research Service, Cotton Insects Research Labo-
ratory (1977) Residues of D rnh1in in Cotton. Prelim. rept.
(Unpublished study; CDL:096l71-L)
0O09977L Di Priria, S. (1976) Specificity of Th pson—Hayward Analytical
Method No. 10 for the Deter ination of Dit’lubenzurori Resicues in
Soybean Foliage and Seed: Research Report No. SR-i. (Un—
published study received Ju]. 19, 1976 under 1L 8—1262; CDL:
096l914—E)
00099778 Sieck, R.; Guztat’son, D.; Ku.lczyk, S.; et aJ.. (1976) Fate of Dim—
hUn Following Application to Soybeans: AEC Proj ect #222. (Un-
published study received Jul 19, 1976 under 1L 8_l262; prepared
by Analytical Deve1o ent Corp., su i .tted by Tha pson-Hayward
Ch ical Co., Kansas City, KS; CDL:096200—B)
00099779 Di Prina, S. (1976) Detenmi.nation of Diflubenzuron ... Residues in
Soybean Foliage and Seed by Gas Chr atography: Analytical
Method No. 10. (Unpublished study received Jul 19, 1976 under
1 48—1262; CDL: 096200—C)
00099791 Bi.rdsong, R. (1965) Field Test of Dimilin on Non—target Organisms
in Virginia: File #179. Final rept. (Unpublished study re-
ceived Jul 19, 1976 under 1 48—1262; prepared by Environmental
Consultants, Inc., su ittea by Th pson-Hayward Chenica]. Co.,
Kansas City, KS; CDL:0962014—H)
82
-------
OFFICE OF PESTICIDE P GRANS
EI IS’ ATION STANDARD B LIOGRAP ff
Citations Considered to be Part of the Data Ease Supporting
Registrations Under t1 Diflubenzuron Standard
CITATION
00099794 N1o, W.; de Wilde, P. (197k) Fate of 60—40 Applied on the
leaves of Corn, Soybean, Cabbage and Apple: Report 56635/16/
197k. (Unpublished study received Jul 19, 1976 under 148—1262;
prepared by Philips-Duphar B .V., Neth., su itted by Th pscn-
Ea.yward Chemical Co., Kansas City, KS; CDL;096204—O)
00099807 Corbin, V.; Nye, D. (1978) Fate of 14C-Labeled Dtflubenzuron a
Citrus under Field Conditions. (Unpublished study received
Dec 15, 1978 under 148— C—25; prepared by Stoner Laboratories,
Inc., su itted by ‘ iompson—Hayward Chemical Co., Kansas City,
KS; CDL:097739—B)
00099839 1 b..il1a, M.; Majori, G.; Darwazeh, H. (1975) Effects of the Insect
Growth Regulator ‘m-6040 on Mosquitoes and S e Nontar et Or-
gan.iscis. (Unpublished study received Jan 29, 1975 under Un—
iaiown im1 r • rio.; prepared by Univ. of Calffornia—R vers ide,
Dept. of Entoi logy, su .ttt by Th pson-Hayward Chemical
Co., Kansas City, KS; CDL;225930—K)
00099844 Ni no, W.; De Wilde, P. (1973) Degradation of ‘ 60—40 and ‘fli
60—38 in Soil, Pond Water, Plants and Fish: Report 56635/20/
19730. Interim rept. (Unpublished study received Jan 29, 1975
under unlciown ai±niri . rio.; prepared by Philhips-Duphar B .V.,
Neth., su itted by Th pson—Hayward Chemical Co., Kansas City,
KS; CDL:225930—P)
00099862 Reinert, H.; Parke, G. (1975) Reproductive Study of —6040 in
Bobwhite Quail and Mallard DucI : Laboratory Nos. 5E-6092 and
5E—6093. (Unpublished study received Jan 12, 1976 under 1148—
1170; prepared by Cannon Laboratories, Inc., su itted by
Tb pson—Hayward Chemical Co., Kansas City, KS; CDL 725306-H)
00099877 N1o, W.; Ce Wilde, P. (1976) Uptake of Diflubenzurori and Its
Metabolites fr the Soil by Rice and Wheat: Report 56635/8/
1976. (Unpublished study received Jul 31, 1978 under 148—1259;
prepared by Pbi.lips-Duphar, B. V., Neth., s .thnitted by Th psorx-
Hayward Chemica.1 Co., Kansas City, KS; CDL:234511—D)
00099881 Nimino, W.; Jouztra, K.; De Wilde, P. (1977) Progress Report on
the Possible Appearance of p—Chloroanuirie, p,p’-Dichloroazo-
berizene and p,p t -Dicnloroazoxybenzene in Soil and Plant Extracts
fr Dimilin Metabolizn Studies: Report No. 56635/17/1977.
(Unpuolished study received Jul 31, 1978 under 148—1259; pre-
pared by Philips-Duphar, B.V., Neth., su itted by Th pson-
Hayward Chem.tca.1 Co., Kansas Citd, KS; CDL:234511— i)
83
-------
OFFICE OP PESTIC E PROGRAMS
R ISThATION STANDARD BIBLICGRkPk
Citations Considered to be Part of the Data Base Supporti_rig
Registrations Under the Diflubenzuron Standard
CITATION
00099890 At d.n.s, B.; Greywood—Ha.le, E.; Macdonald, R.; et al. (197 4) Effect
of Pesticides on Apicu.lture: Project No. 11499. 1974 annual
rept. (Unpublished study received Jul 31, 1978 under 148—1259;
prepared by Univ. of Ca.liforriia—Riverside, Citrus Research
Center and Agriculturai. Experi nt Station, Dept. of Fzitc no1ogy,
sathnitted by Th pson-Hayward Ch ical Co., Kansas City, KS;
CDL: 234511—S)
00099891 Jackson, G. (1976) Dlmilin (Th60140): Biologic Impact on Pond Organ-
isns. (Unpublished study received Jul 31, 1978 under 148—1259;
prepared in cooperation with U.S. Fish and WildJ .ife Service,
Southeastern Fish Cultural Laboratory, su itted by Th pson-
Hayward Chemical Co., Karisa.s City, KS; CDL:2314511-W)
00099895 McAlorian, W. (1975) Effects of Two Insect Growth Regulators on
S e Selected Sa1 arsh Non-target Organisms. (Unpublished
study received Jul 31, 1978 under 1148—1259; su itted by Th p-
son—Hayward Chemica.]. Co., Kansas City, KS; CDL:234511-AA)
00099897 Apperson, C.; Schaefer, C.; Colwell, A. (1977) Effects of Di.flu—
benzuron on Chaoborus astictopus Dyer and Shannon (Diptera:
Chaoboridae) and Nontarget Organi ns, and Persistence of Diflu-
benzurcn in Lentic Habitats. (Unpublished study received Jul
31, 1978 under 148—1259; prepared by North Carolina State Univ.,
Dept. of Ent ology, Univ. of California, Mosquito Control Re-
search Laboratory, arii Lake County (California), Mosquito Abate-
ment District, su itted by Th pson-Hayward Chemical Co.,
Kansas City, KS; CDL:23 1 451l—AC)
C0109 460 Interregional Research Project No. 14 (1981) The Results of Tests
on the Amount of Diflubenzuron Residues R aini.ng in or on
tishro s Includi.ng a Description of the Analytical Method Used.
(( ipilation; unpublished study received Jul 28, 1982 under
r. i .3l; CDL :071020—A)
0010914614 Interregiona]. Research Project No. 14 (1977) The Results of Tests on
the Amount of Dif lubenzuron Residues R aining in or on Pasture
Grass Including a Description of the Analytical Method Usec.
(C pilation; unpublished study received Aug 2, 1982 under
2E2738; CDL:071025—A)
00115665 Ni o, W.; De Wilde, P. (1979) Degradation of Dir lubenzuron in a
Sandy Loam Soil (Supp1 entary Data): Report Nr. 56635/14/1979.
(Unpublished stu y received Oct 7, 1982 under 469 46—238; gre—
pared by Philips-Duphar B.V., su itted by T H Agriculture &
Nutrition Cc., Kansas City, KS; CDL:2L48557—B)
814
-------
OFFICE OF PESTIC E PROGRAI’ S
R ISTRATION STANDARD BIBLICGRAP ’
Citations Considered to be Part of the Data Ease Supporting
Registrations Under the Diflubenzuron Standard
CITATION
050008 1 All, A.; Mu.lla, M. (1978) Effects of chironom.id larvicides and
dlflubenzuron on riontarget invertebrates in residentia.1
recreationa.l lakes. Enviror rienta.l &itcmology 7(1):21—27.
05001991 Stevenson, J. (1978) The acute toxicity of for ulated
pesticides to worker boney bees CApis mellifera L.). Plant
Patholc r 27(1):38— O.
GS01L 4—001 Pels, T., ed. (1979) Review of Residues of Difluberizuron arid Its
Metabolites in Mushro is: Report No. 56683/2/79. Unpublished
stary of data fr eight European trials by Pb.ilips-Duphar
B.V. 3 p.
GS014 1 —002 Makhi ani, G. (1977) M to J. Ci.=irigs dated May 2,
1977: Results of method tryout for DlmIliri in cottonseed,
milk, beef Liver, arid fish. In A Correspondence Pile for
petition no. 7P1898.
S011 14—003 F d and Drug A .inlstration (1985) Pesticide Analytical Manual,
Vol. 11: Diflubenzuron: Method 1.1 (1976). Available fr the
National Technical Information Service, PB82911999. 10 p.
GS014 4—O0 4 Beroze, M. (1978) Residues Found in Soybean Process FractIons fr
Beans Spiked with Dtflubenzuron. Unpublished study prepared by
Thc pson-Mayward Ch ica.1 Canpany. 2 p.
S01L 4—005 Thompson—Hayward Chemical Cc. (1976) [ S1ffrn r of Residue Data of
Dirniliri W—25.] Unpublished study. 12 p.
GS0iL —O06 Burdock, G. (198 4) Oncogenicity Study in Rats: Dlflubenzuron: Final
Report: Project Ni . ber 553-122. Unpublished study prepared by
Hazleton Laboratories America., Inc. LIV. 11217 p.
G50111 1 1—007 Colley, J. (19811) The Effect of Dtflubenzurcn Given by Oral
A inIstratiOfl with the Feed on Toxicity and I or Development
in Male and F a1e HC/CFLP Mice: Final Report: Report No.
FUR 360/831096/B. Unpublished study prepared by Huntirigdon
Research Center. 2727 p.
85
-------
OFFICE OF PESTIC E PRCGRAZIS
ISThATION STANDARD BThLIOGRAPF
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Dtflubenzuron Standard
CITATION
GSOiJ4 4—O08 Thc npkina, J. (1979) Biological Report of Analysis: [ Tecbn.ica].
Dlmll-i.n 99%]. UnpubuisPied report by t US Erivtror ental
Protection Agency. 2 p.
GSO14 4—OO9 Nixrnio, D.; R maker, T.; Moore, J.; et al. (19??) Acute and chronic
effects of Dtrnil-in on survival and reproduction of Mysidopsis
bah.ia. Aquatic Toxicology p. 366—376.
GSO1 —Ol0 Richmond, M.; Eenny, C.; Floyd, R; et at L (1979) Effects of
Sevin-k-Oil, DimIlin, and Orthene on Forest Birds in Northeastern
Oregon. Research paper PSW —1L 8. Berkeley, CA: Pacific
Southwest Forest and Range Experiment Station, US Dept. of
Agriculture. 19 p.
GSO1L —O11 de Boer, P. (1979) Dimilin in Mu.shroccis: A Review of Residues
and Evaluation of a Tolerance Proposal: Report No. 56683/7/79.
Unpubilahed study by Phlips—D. phar B.V. 9 p.
GS01U 4—Ol2 Johnson, W.; Finley, M. (1980) Handbook of Acute Toxicity of
Ch ica1s to Fish and Aquatic Invertebrates. USD1 ?ublication
137, Washington, D.C.
S9999—O01 Hudson, R.; Thcker, R.; Haegele, M. (198 4) Handbook of Toxicit ’
of Pesticides to Wildlife. USD1 PublicatIon 153, Washington,
D.C.
86
-------
0MB A , ’rova1 2070—0057
(Ezrires 5/31/86)
FIFH SECT1ON3(C) 2)(S4StJMM ftVSHEET
EPA REGISTRATION NO
——- -
PRODUCT NAME
APPLICANT ’S NAME
DATE GUIDANCE DOCUMENT ISSUED
With respect to the requirement to submit “genenc” data imposed by the FIFRA section 3(C)(2)(B) notice contained in the referenced
Guidance Document. I am responding in the following manner
0 1. I will submit data in a timely manner to satisfy the following requirements. If the test procedures I will use deviate from for are not
specified in) the Registration Guidelines or the Protocols contained in the Reports of Expert Groups to me Chemicals Group, OECD
Chemicals Testing Programme, I enclose the protocols that I will use
02. I have entered into an agreement with one or more other registrants under FIFRA section 3(C)(2)(B)(ii) to satisfy the following data
requirements. The tests, and any required protocols, will be submitted to EPA by:
NAME OF OTHER REGISTRAN T
O 3. I enclose a completed ‘Certification of Attempt to Enter Into an Agreement with Other Registrants for Development of Data” with
respect to the following date requirements.
04. I request that you amend my registration by deleting the following uses (this option is not available to applicants for new products).
0 5. I request voluntary cancellation ol the registration of this product (This option is not available to applicants for new products.)
REGISTRANTS AUThORIZED REPRESENTATIVE SIGNATURE DATE
EPA Form 8580-1 (10-82)
-------
0MB Approval 2070—0057 (expi.res 3/31/86)
CERTIFICATION OF ATTEMPT TO ENTER
INTO AN AGREEMENT WITH OTHER REGISTRANTS
OF DATA
(To g s a
lify, c tify k four item)
FOR DEVELOPMENT
GUIOANCE DOCUMENT DATE
(Thus firm or group of firms is referred to below as “my firm’.)
2. My firm is willing to develop and submit the data as required by that Notice, if necessary. However, my firm would prefer to enter
into an agreement with one or more other registrants to develop jointly, or to share in the cost of developing, the following required
items or data.
1. I am duly
authorized
to represent the f
ollowung firm(s) w
ho are subject to the require-
Guidance Document
ments of a Notice under FIFRA Section 3(c)(2)(B) contained in a
to submit data concerning the active ingredient.
NAME OF FIRM
ACTIVE INGREDIENT
EPA COMPANY NUMBER
3. My firm has offered in writing to enter into such en agreement Copies of the offers are attached. That offer was irrevocable and included an offer to be
bound by an arbrtration decision under FIFRA Section 3(c)(2)(B)(iii) if final agreement on all terms could not be reached otherwise. This offer was made
to the following firm(s) on the following date(s):
NAME OF FIRM
However, none of those firm(s) accepted my offer.
4. My firm requests that EPA not suspend the registration(s) of my firm’s product(s), if any of the firms named in paragraph (3) above
have agreed to submit the data listed in paragraph (2) above in accordance with the Notice. I understand EPA will promptly inform
me whether my firm must submit data to avoid suspension of its registration(s) under FIFRA Section 3(c)(2)(B). (This statement
does not apply to applicants for new products.) I give EPA permission to disclose this statement upon request.
TYPEDNAME SiGNATURE DATE
EPA Form 8580-6 110-82)
-------
Appendix 111-1
vcr pEC ’Ic DATA R O
A Registration No. Guidance Dcct ment for_________
Date
Re stration
Test not
required
for r
pr uct
listed
above
(check
I am c p1ying w _th
data requfl’ erits by
(Por A Use Only)
Accession N oers
nrm1t-
ting
Data
(At—
Guideline No.
i5W.20
P DQCT
L ’
I Name of Test
below) jCiting
•
tached)
I ASS1 ed
61—1
Icentity of
ingredients
61—2
.
Statament of
c osition
61—3 Discussion of
for tion of
I ingredients
.
62—1
Pre lim.thary
enalysis
62—2
Cert fica;ion of
1 ts
62—3
Ai a1ytica1 thocs
for enforcement
1 iml t
63—2
Color
63—3
P ysic.a1 state
63—’4 j
Ocor
63—5 1
Melting point
63—6
Eciling oint
63—T
Density, bulk—
dens ty, or
-
Sc.u.uoillty
63—s
63—9
Vapor pressure
L_______
63—10
D sociaticn
constant
63—li
Octanol/water
partition
coefficient
I
I
63—12
c
89
-------
Appendix 111-1 (continued)
Re .strat1cn
Guideline No.
I
Name of Test
Test not
required
for my
pr duct
listed
above
(c ieck
below)
I am complying with
data recuirements by
(For A Use Only)
Accession N .mbers
Assi ied
Su it-
ting
Data
(At—
Citing ?‘ ID# tached)
63—13
Staoility
ô3—l 4
O i.dizi.ngJ reducing
reaction
63—15
F1 ri n bll1ty
63—16
ExDlcdaollity
b3— 17
torage staoi.Lity
63—18
Viscosity I
63—19
Miscloi. llty
63—20
Corrosion
characteristics
63—21
Dielectric brea c—
down voltage
i5 .l35
TO COLcG!
l—l Acute oral W—50,
rat
81-2
Acute aer al
LD- 50
81—3
Acute thnalation,
LC—50_rat
81— 4
?ri .ry eye
irritation, rabbit
i-5
?r_ ry aer a.i.
irritation
81—ô
Der a1 sensitiza-
tion
9O
-------
APP DIX IV-i
C cpt.r E IYirvnm.nta4 Pre4.dion Ag.nc ’ f 16 2 .JQ
.nt OJ.i e the iz.s iro Lf) if the & p1l tj prodz
(Idtly £P1i t p1e L a y i 3vt z e t othe th&ri
& pubU c &p1 ob... ..d i j7
£ 01 of the di .t o1 eritio into the pr c,
The a pU .nz &h&11 sub t th th oz &cjon of one or/more
h s i taoo a. ‘ t 2 ent thit PA.. othe.r zzce.- d p clc e p o u
eniuz.tlon of the proper e f a.not r .
c7.an iety of the the pI1 - t & a .U a .i d
4 . e03Oduct. a.7 Ct & 7 wn I as to suc $ ve tng -
the &PPL t.1c .
a fcUow zx .a.&a. ta in r. a.c for our.
(13 e di .a. the sub. oømes of aec eo cxiXD) the
ed fl (b of on (ajtd any T UJt.
t 3 __
x ?e .. . &bou ,be e - e a
() Pcr.&iJ to the ____
fety of a pro s a 1n e i- nsideri on of \he/oi1ow .g data..
th.&O to the ety Of the 113 4.11 data. su j .ce or xpe .L2y
d .U3 otO4IJO . - / ted by the a. p1j nt in zuopor of
(3 tO O0 OOd £d41t V the
£ 04 (23 Za. b othor ’ tte of da the
ciwa.ne ad the ?eder2 .i 4. 73
Poo rug. 1Z I4 C e C (1) Con ne ropâ—J e or effe -c.
(a) if the In tt th a t Of y g ,
___ of data. b zJ ,ed 1nd ‘ h . ’ is one,4f the t7? Vf
ieC 3an was genç 4 1 fr y 0r at toe e . e sj or
e of) ancthe* e on ‘04 or- a.i. ______
b w.b n.e the tO A (or I t s
PTad r. £Ou flt
ary 1. 1970. to r. an &pp j on & O 3iC)( ) Of I
lot use “
per t. a ènt ad to those D?OPo ed lot
one to so M co. or z the o nrz produc t deI the
zeI st - .tio ( 1 the in e e t o \ the
and the origsj ta. tot save the p1i ;
ron ed T5U.e ofl t04 ______
________ ‘C! 0 ! ( q 3 & is
107 tha.&\ay be oa.y-
a.b e ___
(44 r Li. isi i
3 (eX1x x1n/vct rei .r to sopr vaj
of the the i1 .nc a.tsjj i
to &. that 04
baa turn a. ed to onc nanA Id ied (a) G?C!....(jj Con .gmLz of L? e
OT zJ d.aLa. labeL Th- 7 t1 . de Or4tje- a.b.aJl
C l) . 00C1Lon.tlcn of the be13 I label otsi th the ln.fo .
intent to ;; y for -iz 1n iud. aO ZDe fad bY the Ao and the reg-
z the ?000sed prod na. ç ‘- in tinS Pitt. The tents of £
to pay the pe.-v • . Clontl and ;r .
i vith rewd to the prov nently the i0i1avin
of th 1O LI t to the e.r. ont re- C I) ‘ te nae. so 4 or
by T RA 3 e ) ) onf the proc ot is aol4 as ;re.
sod cX2xD (b) of tins aeo
of the
of cc wn e the offer a. p \ (ii) The 3t and Of the
An Off er tO or for
11 to the a.ou c 4 V c pr du
t s of to be oaLd *. d sn ( ci Of se
1(5) The a.p ors na. e. &4dresa . Ci2I The net nLents as
ti.lepbone nu.cnber . in tins
91
-------
16t 10
(lv) The product resisIrellon
number ci prescribed In paragraph (a)
of tlil section:
(vi The prodiscing establIshment
number a. pre,c ,ibed Its paragraph (f)
of (liii section:
(vi) An Ingredient statement a. pie-
scrIie.l Iii paragraph Is) of tI i, sec
lion.
(vii) WarnIng or precautionary state.
Snrsila aa $itra tibed lii pai grapIi (I ,)
OS (liii section.
(viii) ii,e directions for use a.. pie-
•ctiicd Iii parag, apis 1i of hugs ecctlois;
cud
(iii) The use cIs.vii liriatlon(.) as pie
acilijad In paragraph (J) ol liii, section.
(31 Prominence and Iegiblidf . (I) All
worth. .t*tcmesil , iraiiiiic tcpresenta-
hlo,ii designs or other lii(o,inatlon re-
quired or, (lie Iatieiiisg by (lie Act or
use regislationa in tliI pert must be
clearly legible to a person will, sionnal
vision unit must be placed will, suck
Con .pIcuo ,sbnee , ( c . compared with
oIlier worulu. .Istcm niju. dc.lgnu. or
giapisic melter on (he labeling) arid
eapresied in suck Lerms a. to render It
likely to be reed end understood by
(lie ordInary individual under custom-
s,, condition, of purc lia.r and use.
(II) All required label teat must:
(A) lie .et Iss I point or ursa type;
(i i) Appear on a clear contra.stlny
buackirosind; end
uc lint ha. obscured or cco ded.
(3) Lonpuage to be uaet All required
libel or lsbelliig (eel shall appear In
(lie Esiglisli isnguuage however. the
Agency may require or (lie applicant
ruicy propose adaJilionul teal In other
iusigua a us Is considered necessary to
roIi-c( (lie public When addllloisci
t et In mother language is necessary.
all lauding requirement. .111 be up.
piled equally to both the English mud
othet language version. of (lie label.
iii ..
(4) Placement of L abel— li) (IeneroL
The label shall appear on or be lecure-
ly attached to the ign,n uIl*t, contain-
er 01 (lie pcetlclde prodiscl For put.
poses of (lila flechion. a,iui (lie siiii-
branlln provision. ol I lie Act. “at.
csssdy attached” shell Incas, (hat a
libel can peesassaulily b e pectc.i to
trimsalsi cliii ad aluis lug (lie los reecatile
tosiulillous. asual pci intl ol sive I I (is . liii
i,sr,ilelc co ,iiai,ier us tin is . eii liI .ls, a
Till. lO—Pral.cilen c i Environment
wrapper or outside cenuelner through
which (lie label cannot be cltarly reed.
the label must also be securely at
(ached to such oiitai .ie w,aiiiier or cosi
tamer, lilt Is a part ol tue package 51
cissiosnarlly allatulbuteal or .olal
(ii) Tank cai-i and other bulk con-
So mers— IA) Trnnipo,(ulion. While a
prsticlile product Is In tautsilt, (lie up-
pro iriste p,ovl.slossa of 4 Cl ii last.
i1O-iO . cossccrrilng (lie (ranaiio ,laIlori
of ) ,ar.arilouis ,natrtlali,. anal s srrlflerI.
ly tlioio pru,hiioi ,-u cosiceruitsig (lie I ..
(iellssg, ma ,kl,ig slid placartihaig ol has
itiloii , snelerlahs and (lie velslcls ’. cur-
tying them. ‘Ii,ie (lie basic Icuicral
requirement., In aslalitiosi. when thy
registered pesticide proalisct is ira,i-
porte.l In a t.ssk car lausk truck or
other • ibliai or portable bulk cosituin-
er. a copy ol (lie accep(eui laud usual
be attached to (lie •Iiil)hilnp lisper..
end kit with (tie consIgnee at the lInac
ol delivery.
(U) Sloroure. When peulicitle prod.
UcL a era stored In bulk container..
whether Mobile or atatlonary which
remain in (lie custody of Ike user. a
eo sy of (he label ol labeling. inchuuiling
eli appropriate dIrections for lice. shall
be securely attached to (i.e cosileiner
in (lie linmediute ylcissity of (lie dl..
charge con(rol valve.
(I) or misleading •talemeni,
Pursuant to section 2(q)( 1XA) of (lie
Ad a pesticide or a devIce dc’chasesl
subject to (lie Act pur.isn.nt to
ill II. Li misbranded lilt. iabcilssg is
tahoe or inlst sallisg iii ssiy hailicuisi
Including boll, p.c.tich.hsi auth run,, it.-
(Iciutai claims r.asmpics of slalesuiesita
Os’ reput.entathon. In Ihie labelisig
whIch constitute nilabrunail,ig isuclusde:
(I) A false or mlsh,.dlssy slate,nesst
concerning (lie CoinpokIllon of (lie
product:
(ii) A lii. . or mh.Icsdlng ut tenucnt
eosicernhuig (lie ef(ec(Iveuitg. ol (lie
prouiiuct as a te.tIclde or device;
(ill) A false or mlshe.uiigig statement
about (lie valise of the product lot
purposes other (lien us a pesticide or
device;
liv ) A false or rntatcaaling cosniiatlso,s
wlihi other peatlelulca or d’vIi ea.
iv) Any siaLessi uit thirdly or hull
tech Ii linislylsug (lust I l . irsllriahr or
ulrvia.” i-s rrrns,s,usa-su,ie ,i U I ,s,tauaa-ai lay
any agency of (lie Federal Oovern.
nient.
(vi) Tue name of a pesticide whIch
ros,(aiisj two or more piisicipai artlyd
Iisgrcihia-n(.j if tli liSsne assggcs(s one
or aunt e bust ant sil gsirii pi isichimal
active issgrr,il.mit.s even (linsigli the
liiInrl sit usc oilier lssgru ’silrggl arc
ataleti clsrwls ,a. iii lIst laluell,sg,
lvii) 4 hue ii ui es,iusit 5i rui lai au th a
way ui In give a (ni-sr or nslslraail, ,p liii.
ii, ecilsis , to (lie Isuirclsnier;
lviii) hstlici aliscinluusu ’r whIrls negate
or ul.l r aa,.l $ nsii lutss-llssg aiaicgiitsit . u e-
qisireui gusher liii Act asni tlisiu . ragsul*—
Lbs is;
(Ia) Claai,u ,j iii to (lii safety of the
peil klil 1 or iii l ’igrs’illsasl.., issrl,sdi,ig
sluatessiessli such, as sal .” sios siuo l.sn, ,.
oU i.’ ‘ i .si,ihui is., iosii, ‘ Isa ru.ilcs.s’ or
‘‘Iiofllo lc lii lssss,ia,sa asisi $
or wIt liosit lana-hi a qssalli vl,ig idura_se a_-u
‘wisest tsieul ci shiiec(cth . anti
Is) No,. nssise,lcnl sisal/or compare.
tlva. a(s(çsusesit , 0,, usc n1dy of the
pro s isuct ut-I iialh,sg but suit hh ,sil led to:
(It) Coustusi, ,, all isutusisi luigrcdi-
gui. ;
(fl) ‘Among (lie Icuit (oak elsemi-
c ii, hno s, ”
(C) ‘i’oliuitlo,i Ilititoveal ’
(I) flnnl jut fated labeling Ii) Lacept
a.. proyls iral iii purgg ,p$ ,ls fahllilil) of
(liii sn Ilos,, lisisi iii issled labeihsig
riiuiit lie uusubmilted sisal accepted prior
to repiilra(Iaius however liuial prluiteal
luabehis ,g need nut lie shubusltl ed usi,IlI
dratt label teal, have bcc,i l ’roVl ,loii-
ally ada-ellICti by the Agency.
liii Clearly legIble Irhiroalsuction. or
plssilo rrshiictlousa wIll lie accepted for
(luisussuah baud, .iscl , those silk.
acisCuirul directly osilo glass or metal
Coiihuulsse,p or hurst bug or thus , hal.el,
iucl, r ciuroahiurt iou ,, nulist bt of lnlcro.
thus reps odin-i In,, qauahii y
lbl Na,,,,, b,an il, or Sradema,L (I)
1 Iii isiuus,. l,ra,ud or it aslcurus , k u det
which thai p r - ui iclalc I” ouhisct is sold
liusli Ciugirar oss (lie hoist l ,isssel of (I.e
tat,. I
(2) tin “aunt h ’ ,at-i,( or Iraileniark
tisay alt’s’., ails (hit haItI which
(I) ii l lue or uuilile ulisig or
liii hl. lint brr,i 5l’li ,ove,I iiy list
A.hsaslusi , , lisrousgis , rglat,allo,i or
nsu ’laprsiiesilnl rn Jails alhs ,ui us cii uglail.
Ilsiuni usn.s , , u . , , , sua,.l i ,.
Arh ’r’sl I .( I V—h
(conI inisesi)
163.10
Ic) Name and uddrri . of produsta.-
regIstrant, or person for whiai ,n mo-
dusced An us t iqis ghhhiral siam , asial aui
dri&i given on (lie lahial ihiahi lie ens,-
sistered a. tugs nens, susial uululrauas of lisp
producer. it (lit irgIjIruissi s siam. up
Pears osu use label email u .s r gl.i , asit ha
not (is, ijiodsicer. or if (Is. usasuse 4.1 I I.e
petunias br wiu,u,n I Is,. s,a ’ l hi lily- waa
prosiasceal afupesra oui I lie Inl,s.h II ua,ssit
hue qusaihiieaj by laisisrosui tale was, uI , . 5
auth a. “lacked for ‘ ‘.‘ i)isi s Ilust
cal by ‘ . or ‘ flout huy lii sliu ,a.
(list the usanie ii siot I hat of I lie i , us
duster.
lull Net angslphf or inrnIu,s’ 0/ ron
leaf, Ii) ‘list lid wrIght or lusecissie
ol coishatit usd1 1)1’ fiflusiiv of W I Cli
par, or oIlier niata-,lali ausal a.uucll I.
(hue average cosutasil. suuila ,a, ruu shlg iiiy
al steal us e nnlusluiiuuin q’ueisl ily,
(2) II ihic pratlclsie Is a hhailsial lisa.
net cotitent atelansasit ail.ail Ii,. Iii
(dun, of IhsiushtJ lusraiusrp al 5I 1 F 520 (‘I
asul shah be eaprecuati Is. (sisivessl isitsal
Aaust, Ican unIt, of finIsh uuuissa-a-a iulu,l-s
qusari,, and gallon,
(3) lithe pastlelalt is anilal or ,aasssl.s
lId, vIscous or h ’rea iusrh,cul or Ii a ,ssi.
(sire of liquId and aoiIul , I his sia’t cuiss
tent itatcint,,t shall Isa in ie,nsj of
weluhst cc preas aJ . avastrais,l,asii
pouiida a.siaJ Ounces.
(I) In all Case., net cositaust aiusilh lie
stated in tern,. of Usc largaut •usliah,hp
unIt,. I e., “i poiusial ho Osius4-a-,, l l hsrr
than 36 OUnces”
(6) in adatltlon lo the required sirdic
apechlled, net content luacy ha ra.
pressed In, nsetrhc Usiltss
II) VarIation above tulisl,i ,ssrn east
tent or arouuid an avelage i, prisnl.s.sl-
ble Only to (lie titeust (last It reiaue.
seni. slevhafions tin. volshet,le iii gisoti
In assists ctun hag (it act ic V a,i*l Ioui
below a stated rnirul,,uu,us Is not penu.it
led. I ii no case shell hiss’ avr ,sse nuts
lent of (lie iseckapea bus a ei.hissusc,( tall
below (lie s(5(Ca% evesage cnusta-u,t
(ci Product nrptslra,i 0 nunsb,,
‘hue tegl.tr atiout 5s%usnh,pr •‘ulguiu-sl to
list peshIclule Ptoihuue( at list Iiuusa’ s.f
regishratlou, shall ipu’rur os I hr Is lirl
(ireredesj by the lairs-sc I:u’,t hla-,l
tnstbo,s Ho ,‘ or (lit hIs, air r-rA I l , g
No’’ ‘I lit neglst ,albo,s ,.ulu,sh,,-, duals ii,.
ant Iii hype of a sire sisal l yle ilu ,ulla, 5 . ,
sillier pllus( sin lP.. 5 ‘. ‘s ‘5 ‘
I
Chaph. , l—tnvhna m .nloh P,oh.chlon Ag.ncy
-------
I 163.10
sun to ft The rci,ietrstion number
cii i) (lie tvisil ,ed lilenilfyini piitase
shall .inI a ipear In such a manner c i
to alsaseat or Imply recommendation
or rlilloraciis i9 i( of (lie •‘ ,oduct by the
Aurory.
(I I I’,yjdurIn , enfebfI,? ,nenf, s-eyh-
trq(lori number. use iirotIuclsi estab.
Ii I.iiu.,i( reclitratlon nus ,nb.c, prcc i)-
cii by ‘lie plirane P VA pf (hr
lliiaI rn(cblkliiiiesi( p1 wI,lg h the I ,riiJ
uct was produced Ivisy ) ItAr lii ai y
•iiItel ,lø locntlosi ori (lie label ni imine.
dicte rositeiner. It •niiit apprar on the
wiegqii ’r or oisl ’ililc conlelner of the
pact age If (lie l’A catsiiil,li,ntnt rr-
Iel ,,Il,,si number on (lie inslntilI ,i(
co,slaiiirr casimsol be . clea ,fy ,cad
thi,nss ls audi wra ipcr 01 contaIner.
s) IngredIent •Iodemcnt—(I) Oener-
at. Tim label of cccli peeticide liro.luct
mmmcl ire, * alate,ncmst which cositelni
(I.e ne.u an) peiceilteac by wci 1 ht of
cccli active hmpecilicnt. (lie total per.
ceuite e by welg$i( of all Ineil Iuiircdl.
clii,. p ’iil If (lie •mea(lchmhr coiit*lni, ar-
emsile In csiy Ioi, . * g(a(etIi ,,i( of tile
percrsiIa es ol total cii i ) watet soluble
crimciilc calcisiatcil as eleinesilal Sr
iseiiic 1 I.e active I ,iiredksils insist be
dnilq ,ia lcd by (I.e term “active lni,tdl-
,.le” niiii (I.e hint liuireillemits by the
trim hm.e,t inpreille,itj. ’ or this •lniu-
icr Iors.ii of (lime term, wheti appro.
,i, Isle. Iio(l, tt,pni shah be In the
SelilS type atre. be aIl iied to the same
marsh.. hiii,1 be equally •‘rotnlnei. (. liii
sictenirtit Iiie,( hl iRtC(hlfil(I. none” I.
lint irqumlred for pie(Irldes which con-
(mlii 100 percent active lIiIremIlent.i.
l t tileec the h ’i reiIleiit statement I i S
rnmnplrte anclymil. of (lie i’eetlch.le. (lie
irimis ‘ ii lypl, shiiiii riot he Used ci a
Isc i)Iui for tIme Imiiredlent sLaIrm ri(.
(2) rosulon of lnçredfen( •Ialemenf ,
( Ii 1 lie Isitrctjle,i( •(attnir,i( Is nor-
Inch, itiiiilrrml on the (gout psiicl of
lh.e latch If theme l ’ s sri out ld con-
tainer or w,chiper tliro.i hi which (lie
isi rg ,II ,,1 s(ctcme,i( cannot be chrutly
I raiL (I.e lnsme ,hle,i( s(shfsne ip simimet
cl,o asillear on silich. onlaite cosiIahii ,
or WImlil.pr if the nice or (olin of (lie
icrke 1 c , ,iak a It lrnp ,acttea ( ,t to
Place tlir li.p testie.iI slat client on (lie
hiomit laud oS ll. hahn. • ,nm i.iln.Io ,i
lucy Ii araimlnil (or II., lug, cuhleiit
alnln.u , , ..i( (0 “l’i ccr cIacwI,r,
till. 40—P,oi.€il 011 .1 nvl,onm n (
Ill) ihe teat of (I.e lnare.tIent state.
ment mUst run Palallel with other
teat on time panel on which It appemis,
•iid mod bc elcamly ehle1lsip sl.h ,ctiie
horn minI 11 1 1 , 5 1 not be placed in (lie
body of other teat.
(3) Namc to be used fn ingreilli-af
•tafrmenj. Time name mmcii for md. Iii.
•r dhcn( shall be (I.e acci.ti(ed
romnmnoim • name. I I there Ie one. mi.
hoc ed It (I.e chemical Jiptue, 1 lie
COiIlfl,Oi lmflne may be iliCij aloise orily
it It Ia wet, mnwii It no conuatios . licine
limos beers eitalshl,hied, liii ’ chemical
nsmC mlosi shall lye ulenil In no Cane
will (I.e mine of a Ilsilemask or simopil-
etemy name be petmltte.i iisileni antis
risoiC hiss htrri mim-cepteci as a com,uion
name by (lie Ailmnuiuia(sat under (lie
*mittuo.l(y of flectlos i 26(ch(l)
(4) Statement, o/ pervenha es. The
luercesitmir. of Ii .SmeuhInr ,i. milieu he
stair.) in t i-nis of ,sehglu( lo wei h .(.
Tiir eon. of psrcmilamna of (lie active
ans i (lie Inert Inyredlniuts shall be 100.
I’erccnua ns ahsslI slot Ire eajireeceil by
a ra,i e of values such a, “22-2e% If
(lie uuie of (lie pestlrhie prinimict are
enpreased as welphu( of active Isisreill.
esst per huh area, a e(a(cm,,it of (lii
wriehit bf active initruileist pet ,is ilt
volume of (hse pesmilcitie forniulatton
shall also appear In (I.e Iiiuredlent
ststein e nt.
(6) Acccrurp of •tited per centage.
Time hcfteflta 1 e. ‘iven shall be us pie-
elne as pomualbie P Il ctisi ioo.l mciiu-
faclum in practice. if (l.ere may be tan-
avoidable vitiation between miflsufsc-
tu,In bstchu a, (ire valise slated for
Cccli s iIve Imiiteulhi,it shall be (he
lowest peictn(ale whIch ins, be pica.
esut.
(6) Peferioraf(gn_. 1’ee(ici ,1r wlsklu
ch m anme In chsemli-sI eornpos .ltlo,u iii-
rilficantly miu ,.l meet (I.e follo h ,i Ii-
bell, . 1 regsslme,nenpjs:
(I) In cams wI ,tti It I i deler,nt,i. J
(lost a 1 cImi iomuntsla(lo,i cliiiiijti
chsenmlc, olnIHualllolt sIiuihIlcaii(iy ,
use sift set usual bra, (lie lohluwii,
•lat i, .,i .( li i a tuionilm,t,i( luismithois oil
(lii- label: (liii for sale or mine after
humid
(II) 1 lie prn ,Iiirt mijet sued all lain-I
cmliii’s UI , to (lie a ,h,a(lsp Ihiise huh.
mini on this hahn-I.
(3) Ine,f ing.i-iII ,mif , ‘I lie Adi,iiiihi
(muir she? rciliil e (lit sinful- iii ci,y
ins-vt ln,redieiihi.i lo be hunt In (he
Iliamedlemit statement It lie determine.
(lost such hisp IeilItnt(mip may Poir *
linratil (o mcii or (hr environment
(is) IVarningj and Precautionary
atatrmenf, Itrqiih,ed wernhui s and
h”rmautlnnary statensenis concsrninq
(lie lnm,e ,sh CICaS of loSIcoisupical
hia.zcusl Iiidhuulh ,ig lia iird to chuhltjren_
euiviruiimd,m(ah hiararit dish pusyalcal or
chemical hap-at, fall is, 10 two hoops;
lImo-u .. rcq.iIme,I as. (lie front pa nel of
(Iii, habeIhiig and II .oj which, may
Si . .d b .i e
o to_
IJd. 10 .. , ; , ,
b ..i 5
i i . s h y-li
(I) ItI4IIISI,I Piatanf signal word_ tA)
TorIclfy Category ? All pei(ichde prod.
lid. tuuee(lm .p the cihitiha of To*lcf(y
Calepor, I aiialh bt , oq (lie front
panel use eh nsI word ‘f as [ e,- In ad-
dition IS tIre Product was asetyned lo
TouIcI(p Catriom, I on (lie (jails of II.
otal. Inhusha(Iosu or degr.,a ) (o*lclty
dh’s(hmict from skIn asiul eye locil ci-
fec(s) (lie word ‘I’oiusosu” shiafl sppesr
in red or. a bsch.atois,i, of dIstInctly
ton( ia ’ s(In 1 color arid (lie •htuhl and
CtOlalp , ,t. shah ssiuirar In immedIate
siroihs,iI(y to (lie coid “pohsoit
(U) 1otlcfg ,, C’ntepory II All Pestl.
m chic P ’su .l,Iel mec(h, . 1 (lie culterla of
loiilnlty (‘sihi ory II shall be,i- on (lie
fros,t hahn the sl iuah wouil
(C) Tof(clfv CaIcgo, Iii. All Death-
chic pm uiiuctc rnccthgs 1 (I.e c’l(e,Ia of
1 n ’ slcl(y Cainmior, Ill shall bear on
lhie 110111 iia,uel (I.e word ‘C.u-
tins,”
(I)) TnrI ft,, IV All pe.(I-
Chic ilisuhI sirl ’ s lurch 5 ,, (lie ci It t , Ia of
1 (‘shell 1 (I IvRofy I V iuliu .II bi-si oil (lie
is.ii,t Isnisni lhs , . mulmiuivi wo,sh (cu,(hsu,s
mh:i I, , ,. o/ •Iq ,, ( lIar ( s,uv
ni y,.ni
iv
(h..$ us
a.
ba. • .
.—. Pu .w
ToahcI(y Catepoty Is not prrml(t d
escept when (hue Aiens-y sirtn,n,in,mi
that auch habeIIri hi iir-cca.ary to pre
vent unreasonable adv.-, , ntf,r( on
man or the Cfl’lronm, t In no ca.q
hull mote than on )umnnalu ) .srsi,4
•lgi.si word appear on lIst (‘omit panml
of a libel.
(II) Child Ihaagrd vrenu lng P’rry pes
ticIde product label shah bear on hts
front panel thu. SIa(tWt, ,( ks-tp out of
teach. of ChIldren.” Only in casri
whiete (lie likelIhood of con(a - wlhh
thIidr 11 dunn 1 dh ,(,ib,s(1o 0 ma, tnt-
ln , stors e or use I. deflloi I 5 ( 1 p(p4 by
(he applicant to be “shremehy nelnoiC
or lithe fli(tir, of (lie pri(Icldr Is sun-li
that It is approved for slit ohu liifiis,la
Ci small Children may (I.e Auhlnh ,iI. (,a.
(or waIve (liii req,,ircsn ,i(
(III) Xfaj,mmng oF Pracfl at tr eat
‘fln(—(A) Tozfc((p Cat.pnu, I A
statement of practical ttisihuir,it uilm.t
aId on O(hieg) shall appear on (ii i . (mon(
Panel of (lie labs-I of all P ’uhlch.hra lall
hui Into 1 oddly Calean, y I mill (lie
hash of oral. IiiIssIa(I , ,,i flu •hniu,,ah (iIr.
lilt y. I lie Agi-sury lila 1 ilowu-vi
5• — - —
i•. -I •‘b I • 4
- • ‘I 5 ii ’ • s. -.
°• : A i Eh1I)LI IV—I
.f l(contjnued)
I. • is, iii ,
Choph., I—tnvI,.nmafllol ! olstiIon A .ncp. - I p is I. •. • i 162,10
5 i...,
appes, etsewl,,re t pstIIir nnqnI, .
nie l COncernina ronts-sit placrin nh
(ype sire amid t ”oml.ir,i ., air miivrst
below,
ii) Required front pans-f ‘ t nfrnu.-nf,
WIth (I.e escu-pilon s - u i lIre rl,Ihd
hiagand wdi-nu ,i; ,ilat,-,iu,n( liii tia me.
mitslH-d on (hue fromui pain-I ni II— label
I . by thur baldly C a f e o.
1, of (lie pictichil.. This- rml.-ao,y I. a.-
Shut) Ohm (hoc b I of I ii , hulgiigsu(
liar.,,) shown by aim . of this- h li shls -alot ’ s
In (hue table below:
F -___ ?w4 , ’ s 1
I • —.1
s’d i 5,, 10 t * Q a -s 5 P I1, 1 ’w I -lv SIWn S
‘a
is sd b ,5., 5 5 S .v I .wiw._ pu
Is ..j i.y .Ø.., pui P j Is’s au _ so
nw-.sl N s sv.ssl
tOydp 55 . 5 5 Iut.5 5 .
4 I **a
sSè )
, y.ap ,,
P *55
B. .,.. I.. ..
•4.4 __ i . Is ’ sIIwi 55 g 5
I - .
I H,
d 4 ‘..aw .a
I, iu.u
-------
o 161.10
cat treatmetit Ii some telcrence such
o ike ..ts(ement ot pisctic .i treat-
mc iii on back panel • . 5ipir., o” the
110511 •i’niicI neog the wotd “Ioi ,oii”
and tim Oh iiii amid cionabones.
HI Other toxicity categorli , The
n1 .itcniri .( ol practical treotmesit k iiot
acquired on (i .e (rout pasiel cac pt a.
,lr,c,il,c .l In •..r.orasph (1.11 I )(llI ) Al ol
(liii u.rctlo,i 1 liii PIg . 5)lIculs .t may (tow-
ever. luritule such a trout panel aisle.
nirmit iii Hiu option. fltotementa ol
practical tiestrnent .rc. lmowevr,. me.
quired eincwl .cre on (I.e label I,.
cco,d with par.a,aph (1 .1(2 ) ol tl .i
section I I they do riot appear on (lie
I, o t putmici
1.? rlacemeiis and prominence All
(I.e acquIre front panel warnhsi stutle-
uneni,, ,l.alI he touped io etIter on
(lie john. and .i . Ii ap;.r .r with . lIi-
cicitt proiniiirs,c g lalive to other
Irosit psuirl teat utnul matiiiI material
to mitlie them unliktly to be over-
loukcd us.idrr customa.y comiditloti. ol
iitrch .sc anmi tine. 1 he iotIowls, (oWe
show. (I.e minimum type aire require-
mursita lot the (gout pond waniln
sliteniemit.. os. srioue aites ol label ’,
lii) EiiUlt nn,enlat ? a,n,di Wis re a
i, .rniii cihsia lo (mu tam’,ri ot tiIsuui
a ci ,iuiiiia Iluu,,i. mu, Ouili d omen S ii’ 0111
m,iutl’,. pm rcanIlomi ry eiatu-uu,tmiii . ore me-
qiui u-ui sinfi,,. (I .,. iiitI,,, o( (Ii ,.
isn’ni ml 011.1 ll.r o .,.m i, ,uhnh e firern.,
liti 40—P,ehsshlas, .1 Vnvlr.nmsni
1 1 . - i d
• S
I. I
I t I
II IS
I. I I
(21 Other rmgnlrrd looming, and pre.
ca.mllonnry afntcnienl, Tise warmilui.,
. ...ii plc-cautionary ataictni-nt. ae Ic-
qtulrcd below push oIi ,ra, Io cther on
(lie hutbel Iinmlrr (lie penersi i .camhhiu.
hecinustion.ry Btu .teme.iun” amid
tist .ler appropriate a .bl.ramiinp ol
“hisrurd lo lhimii,in. nd i)(munce(io Aid-
nt I, .” ••Puivht om.meuitr’i hipzsrd cmi
lhiyilcai or Ciieiniruil ilarard. ”
(I ) Shiicuf So ?im .n.an and domeilic
animal,. (A) Whtrr a harard e ,iat to
humosic or domeetia ,iimnai,. thu-call-
(busty •tatesn,sii.. ore reuhisited hull.
tatinp (i.e iiaitlctsi .r iisirgirni, (lie
roiste( ) ol eapneutt suid lit. recsti-
(mu, to bt tutlitti to avoid •cvklem .1 ,
i .uitury or dt,n .pe. 1 lie piccoimlionary
p.1. 5 ,-spIn .11011 be i,nuneiiiateiy pie-
teulcmi by (i.e ci .pro um late l.arard .i mial
woid.
(ill lire toilowini labia depict. typi-
cci precwtitlmnuar, si’ttmemit. llseee
statemrn(, mount be modlilemi o cx
p.uided to teliect bpecl(ic i,ar.am-da.
hsijuury ôr du .anm . P iamj .le. ol the
linrutrul ltA1u-a,irpil.u .ini tl. ciucu,m-
eiauict-i lsustl r viii, ii they are req.ul,emi
I s uhiow:
(A) ii ft Sienticimir im,i ru.uir ,I ( ii i mitut
4 .inr IJ ,IC rc.•,tniu, a ,, a, live qurihirmul
11)0 01 lr -mt.’i. (i .e slatu-ment “Thu r .ti-
Clmhe h Tr .alo to WiluIljg ” I. required.
(ill II a p athchip intended los oust-
minor line cnmiloim,, miii active Insuredlesit
with a 1kb AnIle IC.. of I l’pm or ieii.i,
(I.e 3101 i-tuim -m,t “3 liii h ’eui lici ,lt 3 Tank
to Pkii ” Ii icqutru-ul
I( ) Ii a turiticlir luiitmi,Ird lot ptst-
door tine rop ,tmtl,in all ac(iv I ’)RICIIICI .(
vhS ii am. asic,. acute old it).. 01 100
or leti. ar a Auibitcuite dietary
iC,. of 00 or irni. (lie iietemeui(
i 1,11 I’r,tim idc Ii I o ic I a Wihuiiife ” ii
trm (m,irrii
IS)) I I either uicri,irnt l .Iitory or field
i,uuhl ,-i ilesnou, ,(ta l ,. (hot one ol (lie
I ’ctiiri ,te suop n-nulL In (.1.ihIy to
ii ut liii . or mniain,nnin ti. . illatemeni
Ii ) I)frccflona for V ie — fl ) (1en n . ,f
Yq,uimemrn(j_Ilp Adeq,ii p, and chum.
ily of dic.f(qj, Dirrc(Io . (or
must tie allied In (elm,, which. can be
Coolly rtiml am,d usm,m lem ’ ,(otjd by (he
0vertlt lirruton hlkily to use or to lo-
pe, cm i . (lie tune 01 (lie pri ’ticide When
Ioiiow , ,g miInecilo,i ,, tonal be cmIpqi u st e
to pm olm-m-( (Sic pluhahic (p oni I i amid and
(miii liesaomi , ,i huifimsy a,,d to prevent
i’ 5uuCn oui i,ip amivrp,. el( ct on (lie
Curl, i.ii,ne pit
miii Pln ..n ,u- ,,f (a/ dis-e ,- 1 1 00 , f a a- tue.
1)1. chIosiq limp’ ft 5)hltfur Ott auiy portion
oi (Sir isuturl iignvlulr,l that they are
COmt -.I.I ,- ,uo,,, rminm, i. In br u-sicily reaut
by hl ,r mud 01 hue s ’r ticffl himouh,act_
I’ IIloslc fur lIne m.iay nh’i.car on
5•ihu .5r,l hr pmsu 5 .I.I, u ,,nII,—r iiSm—5
Al. IliflIX IV—l
(cont Inued)
*111.10
“Title pietleide in eatrems-ly lode ho
wlldhiic (list.)” ii . irqislremj
(El Por tuna-a haivoivlu, 5 loll., appiim-o.
lion to a,,Ici,l(,,, h rmoi.n lotr,if,• or
shale lieu-n. or (or ri.ong,,llo utt,ai. ..
ment irraimemiluu Prt(ici,Su-a (o*$c in
poihinatimi 1 ipiiureb , . miimu4 hi-ut, Agap,os,,l
at. imibel taulto,iu.
IF) For mull omihmlutut, line.. ntt, . r hIuut,,
aquatic AIil,liC,.( lmiu,i I is ,- ipilarl mnui’.i
bear (lie rntu(iman - lC .- ,gm out ol iutki-t.
pouimli or atrearn, I)n mmcl i-null stun misS,-
w*(a-r by rSm -utnhu ,g of .quulpn .i-,u( or mlii
poioi of waql ,- --
(iii) I ’hs,iiraS or cArmlcof hn,uy,dg
Ws ,,itn 5 atu’iemrni,. II, , liasr ii,aiu ,i,ii.
ii )- or rnptouive rl,iumnr(e,inii ,-, ci 5 iim
pc tkimlu- are reqm.h, a-mi utn ichiow ,,
(A) If ieqtmh,ed by (tie A ,titty. pumi-hi
pilmutemi or Irftpitlc maIler ii. Pa-n-mImeS,
attached to each pockape ol (lie tacoti
tide, or placed witiilmi tutu- ousLilmiC
wmsppe, or ha,:
(ii ) The label bt r, • ‘rftrunc, lo
(lie hlrtclhoai. for un. In ar ornpauiyi., 5
healiela or cirtisla,,. imurli si • Ru-a. dl
rectlon, in (lie enclo-urd circular” amid
(C) liie Admini-uhmalor d .itnrntp,.. ,
(list St Is not flecratary (or audi mhi,.-c
(Ion, to appear or. Ii . . lutiiu-i.
(iii) ?xctptlon So ‘rgusirvnua-nf for
direction for U s e — IA ) Iletahlu-mi mihaic
(Ion, (or use may be lanil llrd isa-ian las
bchl,i 1 of p ’nI (chmlrut which a, a- iuilrp ..I.-ul
ln u,ae osily hg snami,ulutr-(i Irma a-al iim.,I
t,cI oIlier (luau, Sur’lJ-i, h— ili.I.ai ‘a Sms
I. _g_ — — — —
•,. .• h...d p lb. ‘w’.
• s.-d w’d
Abs. ’, l i i . 30
- - -
Chiapt., l—rnvironm.nue, Pioiicilo Aismity
- _ [ i1iiIii *.d -4 -
lA m r-,.,u,.m,. C —.s..a.,
r. c , ,. ,e , , a a.. I , • a..aau-,s.. t.s.. . . . u- ,_, .• s. . to p, 0.. ___
•- .. -. . a. s. u...u.. .-m..,, I i . ..n u-..- ..
i tu- I .po... . s..,... .. . Si. i , •_•
1 . -aOl
h.I. p.*4 . ., o V ‘.4 —a-4 a... am V I vs 5 r.....4i _ . p . o . . .. s... . , su-,
ls.o . 4 . *b . Is ut s I., IS I. bs’, Si I dais.’,’, ,., . a 0. u-i u-..-b... — ...u
sá• I. lu-.,a ,. 5 .... lw . — .. I. ‘vs-as,., d i v. I0 i u-. . ...
AS .v.. ps,i..l..d . - .s . .. C..’i.nu. ta..$s- r . .a . (1 1 11 a... w ..s- i_ _
P..... 0. ..oi p..- ’ , fra. a’ , -ia’... ,., .. . 1.
•..a.ps-.5s. . ,S ,, i -p ‘,, . - ,
(I) ia.s-w.. .p..,, 5
Ala b-b. lo- V__ _____ (.a.. . .% P.na . . .U , ft. .p amy 5. . - a, .4
- ‘I- . .
PG V ad s.. 5o V_ —- — — 5b..n..m . Pa .. . bu-.. ‘.a’ s.d ..-.
.- . d.. .i .. ... Ito- V _. __. — s. a .s.s — i.. au - —. P..... -- — —
a
U
le- 4 r*g
P*cv4sosy .lslvs..4
Od tl.l .I .t . da,—d la.4 .p
by b& ç £.S.vs-p
v . s-d
bsd sut.a-ia
I
- -
- -- —
raid aiu- . . ,os I I P. . .1 ,_43 154.5.4 — al. . ,4 .d
Pso ,, i *b.l 0. aiai Is ..V .. Sw lAd a ‘ .y
s d . . ) 0. . i ,ai er ’- —. — a.. €5.54,
l’i ’r4 .i.lvs.s4 ci 5’.cP.d I..s-..d..
IJ.y to l.id U a l.. . .-J Is..a.d — dw.-4.d
y
Osut.a’, lvm .S Spe s .d dSn 4 1 . ops Iii d s
biAsSu-it 0. wi psi 5. ys. • ‘ . aM a sn
ó.d4 v s.. p ,gyfs.. a to. , ‘5. $ sd
55. ... .4w. i .s.N I....d,d a 1.5.1 P a -i. 4
0. . -., a.yo I— .’ ‘455 ie.,t P. rom p si ti ‘ v.a
I o.v. P. aidS Ii . n .4 b...e. . . -. so...
‘rn a’) 0. s’uI psi . a’ a—’
o5.d4’ IAirs ,roi.ui A . scd .1.1.. . -t. .. A,d I
I P—,’a.--.d Itd.u.d. dio ,oi.•d P .o. ll.
‘ 4I’I 4 . 44 I... .d ‘.o. . ldIs. .Si, .5
d.o.d
. . ct a u-i ‘*‘.ê nu- l I l .
p .ç - 1. ls a.. sad u4.4_, l su-p*4 I
a
A ,dd as. om .45. d At . .i s. ‘ 4.44 , 5. ...e ii
se# i 5. .o . ai.i 1 0,4. . . ‘45. pIs ”ap 1
lv
. -
..‘-“d — . ‘4.. t.,.... .5.sa ’ ,s Iu-en-o
.i.’. ,i aid ai*to, . ..4 .,-,d,d 5
Iii . .,si ..s. . o pAsd I - - —- -
s.* nai u- ..o.i sn..d.ot I 5.5. ... p ...idi
i14 .poos s .4a’ - . . . s . ...y*.d I
-------
• 167.10
(I ) The Ititmi clemily mhowp (hit the
P’odurt It Iiilpuided (or time oiily lit
inmiiiifceltiilip proccti.,ee mud mpe’cmcm
(lie lypria) ol tirodiict. Involved
41) Atleqiaste liilo,ma(lon much at
teelinirci ilata sliecte or biill (int , I,
tvmllgil,ie to the timde upeclIyln the
l Ie of liwbirt llivolp tl mud (I.
i ropcr ij,e In iic,iu(mc(u,ln. (‘roceats-
em;
(3) The ploduct wIll not conic Into
the iu.fidi ol the lene, ml public e.ccpt
miter Inco,tior.(lo,s itito fluilefied prod-
uct.; cud
IS) 1 ht Admlnl .(u-atL r detennIni is
(hut such dhtec(io,is etc hot tieceuuuaty
to preve,i( UuitraJioliAhule adveise ef-
fect. on luau or (lie cuivlronment.
( II) ) t.hkd direclioiim (or use msy
bui oniltied from liii, lcbrhliii of peati-
tithe proutucte (or which male I. limited
lo pfiyuuiclmuie veterh,iaiim, or dru 1 .
pitt.. provider 1 (liii:
(I) 1 lie lmb l clemihy itatee (let the
piotlurt I, (or lime only by phiyelcli,i.
or velcihuue,ianuu
(2) hut Atiunhuhateator de(ermuuueu
(hut such directIon. crc not neceetaty
to pitvr lit Iiuirruruionah,IO sdveree ef.
(cc l . on mars or hue eusvironme,i(, arid
(3) ihe product is. sito a ulnup end
rcRuuuutrd tinier (lie puovlelon, of the
Fedetal rood. i)r*up tui Coeme(lo Act..
IC) l)clrilied dhtectinni for u.e Ins
be ennltteul (torn the lmbehIn of wit
dde ptodi,cbi which Ste Imitended lo s
lilt only by foumnuulttorm lii pititarlup
prthlrldr . for sale to the ptiblic pro.
idtsi (hut:
( 1 5 1 litre I i inlotmution readily
avuhimble to the formulator, on (lie
Coanpomilinui touchy, nietliodt of lime.
•h’pilcsh,Ie c i i i lctloiiui or ilunlta(to,ts..
curt elf etIveneet of (lie product for
pesit (cl e hsuirh,omem:
(2) TIm label clraily state. (fiat the
Itroduct hi Intended for uee only in
unanijfactuis hip, lommuhatlimp, uiihs.I ,ip
or tepnckl,ip for liCt c i a pesticIde mind
specifics. hit lypehe) of pcut lcl.Je prod
un. iuivnivrui,
Ii) I hi hit ndiic( uis flimeuhy ruanuijec
(tired, iou iuim;lat cut. ililiril or Iep)u%ck.
macmi i i Vrmhntetcii: mini
I I) I Iii Auhu,uiiih l , c(or mit-ic, moist,.
I lint Audi til, ret Irsuut mu r uunt lied-tin my
to pm cvcn( mutt rni,tui hjii. miuiv , it ’ ci
tech i oum I,inn sit (lie niivls muui$u iu ’iI(
this 4G—r,.,. tk ,, .1 tnvt,.nmsnt
(1) ullfenta of I1i,vctfon. jbr the.
1 tue dl leetioiie for lime mliii Include
(lie loltowimip, under (lie liemilluip. ••I)l.
iection. for flit’:
II) The atatenitrit of ‘ .me clamsuilica-
lion a.. prrmerhiped in (41 (0(J) itninedl-
•tdy under the liecdluip ‘flirec ilouia
for time.”
(Ii) imt tediudely b,low (lie stale-
merit of time cI cinifIcatIn i, , the etate-
merit “II Is. a vIolatlori of P ’eder.I i w
to time tutu proiliurt in s. inamu ,ier lmicoui-
mietent with II . iliwllaup. ”
I lii) 1 lie •lie(e) of sp iilcslinn. as for
emsinpie (lie crope, auilinaim,, sled, or
outed.. to be tteeled.
(i v) flie (atge( pe .t(e) umioclated
with tici, mite.
Iv) The doiep , rate retoch.(ted wills
Cccli mIte and peut
lv i) 1 lie method of apiiiice tloit. in.
cludirip lnaitn ,rtloiu, (or dilutIon, II me-
nutted, amid type(s) of shultlhcitlon ap-
palming or eq ,ulp ,nriit requited,
(vih Time frequency mud Ilunhip of sp-
plicuiuiong hIeceotary lb obtain l (ectlvé
temuiite without Cilialuip uiutcamoncble
autvertc effect. oil (liC efivlronintnl
(‘Ill) ttpet-Iflo limitation,, on reentry
to area. whicte (lie I citlcluit (it t been
applied, Ineetlup (lie icqiuh, elnent,
cnnccru ,tnp ircuitty provided by 40
Cr 1 1 t’.jt l’P0
Il’) tipecilli, dui-t tioh . eohceiri inp
(tie uiniape arid lilmiHunal ol lime peetl-
chit Muitj Its comituiimmer, ineetiui the m .
q ,ilrclnr,ite of 40 cm lad lee. Theme
Iii.mtrujctlon. tush be prolupeui mud
appear Under (huh’ liessiluip “Blorspe
suid f) mpotuat “ ‘flitS huesuhiui, inusit be
set lii type of (lie mmmi mhuiiunu ,t shieg
at tequired for (lie viuhlil tucesid
my (lice Tuible In I idi I0(lsflIuI,pp
(a) Any hhupiltalho ( or rcsutt lc(lonj din
lime uetJulrcd to prevent umuurtaaun%We
sulveitme rIled., inch, mm’
(A) fleqimired limteu’vmip be(,een ep-
phlcuitla,. mmii i lis ,,em,t of food cu feed
cr 0 1 ,.
(1 )) flotshio,iu,l crop ea(iic1(ona
IC) Wmriii,, am required cpuiuuii( mime
on cettshni cropt, anusmiele objecte, or
lii or euliscerit to cc, tmi,i at Cat
Ii)) hhtcuerveth)
In) P ci icnhiiclt ,i hut pu ’uulhcijts. a
slmirunru,t (htmL hut i’rtuhht-h,te luCy ht
•i’uuiin,h mi,uuirr (lie till ret umi5iet vlvloui nl
mi ri—i lhlhr ,i au,u,hhu alom whip hi mint is 1 pa
I. nily mirtm i—u ,l Al Slur’ iii,’ ,,V A,i,,ul, “ii.
I, , ,, u inn ’fl,p 1 avahhahl, to (ito
PeImohi •Puml,hm tt ic peel icl de, lUuiCM
thin Aps ’,icy hums. d.tr’,niIn J tluc( (tie
pruilcluie mnmy only be III)phhCd tinder
(lie itluect CllDCrphjhoui ol a Cettif lu .4 ep.
(‘ilcator ‘din I , phiyticuiuhy pit- tent
(I’) Other tierlhiutmit hui(ormmthon
w huhchi (hit Aduuiluulti ‘star drtcrmlnt ,
In lie fleCe*imry hot- (lit Protection of
tiiaui arid (lie
(Ii . Snlean n of (lie (-ln--”l.flcuuliom,.
fly October 23, i0’l , cii luetichde prod.
tucti num, ,L bruit o (hit-h, isbn, a atsie.
OutSit Of lute CIL’ tsifhrathon i
hi imarmatmuphut IJ)Ih anti (2) of titI . sec.
(huiui Amiy imnqthrhuhr proiluuct lot which
itiuust lu 5Ir Cit S iaS.uh(it- (or menersi uu e
smuih Otii ,, lot rCttuirt d lime tmim ii he
sciPtur alely Imihiri rd uircotuiI p In lime ha-
hti-hhmis. mitamnhaid, met (a, (hi in (liii imumb-
trt -(toup amid ‘uhiptil be itimuhteted ci sept-
mit prorlumc with Ihiifptrnt teii’utrui.
hio,i umuumubi-is. ePic hcmiuhmip direction,
only lot peiuclmh mllr(3) auth (lit other
bca,imi uhhrcctloii , lou triutlicted uise(a)
eapciit thimt, it e ploduirt hici both cc-
et4lc ( ccl mi,e(su) mmiii aruiermi hide) both
of (lic,c hid may appear on a Protimuct
lnh,m ’i 1 i (or tcnh,hc(eti lime fu el 1 Prod-
luclu siliali be siubject to thu provisIon,
of I II I ] lO(J)(3p
Ii) l/i C1o ,j j . 0 0 ,, PestI.
cult Proh,uct, hca ,i , 1 , direc(i 00 , (or
iiit- ( ’ u) cIst. l(i 1 semietal much be ha.
tt Ied wlltm time evuct word, “OeneIci
Clnt’ui(hcm(lo,i’. himiuotdl ttiy below (lie
iicu u uih,i 1 ‘ h)irtclho,u, fat hlac “ And te l.
tleiitt to tli CrucIal Clcsmi(ic.fl 0 ,,
hid SUpprel , or Irliphlt , (lust (hue pen.
etuui Imililty of (hit pCftticid eatend.
btyo,u ,i (liote Ilulpomit, mmiii umeg con-
(uuimie ,i is, (hue I)i,ec(horis or flat wIll be
cmithtie,ed c Smut or mnutheadiny state.
nirmm( uumiuier (lie itetittory defiuul(ho,, ,
of mmii, hum ntiiuiy_
I l) 11 ’tr (cfed (lie Clu1fl(flc p (fØ,
t’rnIlcl i , f)totiumct. h’em ,ilnp direction
hi C(5) dltuutifled rcsmlilc(,ci shah
(mq’ ,f Imlmtcm,Imi . of reminded Isle ci . ..
Ciiis 1 uii ion ott (lie fiont lunch at de.
ulr ,hImr- 5 itniow:
Ii) S ,upnj panq •Sfl(em ,if of Ivilrkf.
(IS mm i i’ rltv,ilfhca,iori (A) At the lou, of
(lie Irrsumt ittisel of (it t liuiiei, ect Iii (tue
ci i hue mimic usih iii mmii ai,ra uim m rqiuir eu
lot imumm 0 , hAt-nut mipuiqi wautIs. (see
Itul,ir imp 102 mom liulyji mmmd tm h’usrsr-
big hi hi imuhil, u 5 uumoiiuumueuut C
1 u mullu, ui-, ,,i , ,‘n,.i
Arimuluix tv_I
(cont Inued)
1161.11
(tie f,on( paitet to make It umuhikel, to
be ovetlooked under tuuihnnii,y r miu (i.
(toni of pu ,ctiaie and uiu , hit •tmi,.
mcmii “flc. ’ ut,lc(,’ct (hw ’ PeahirI i -’ sliuuil
SPpear.
(0) Dlrectiy brlow (liii atahemenl on
(lit (rout penci a uimmuiuity aimlr ,,,, . ,,
of time (emit of rrmi,hc(Io,i hImipo.r ,$ mu
a pneconi,ft( 0 , to tr,i,h , 5 i 09 u auiutti
Spptuir, II suit I. meshuinitti In resjh(h. .4
Ipplicuitor. (tue IOhiOdiifl $hAlrtn(’ui l ii
tequireci: “For retail ui, to amid um,.’
only by Certified A lsguhita(a,j n, u-n-n
loin Under (lint third mumn.’tvi,ion and
Duly for ttio,ue ntis-n toys-u ru by lb .. cs-,.
lifhctj Apiuli 5 t 0 ,’ 0 s-t I hiijutl mu ‘ U,
however other uu’mimuhtuho,y rrstmii-hi 001
s te Impn (lie Aiimnimil. (,mi,o, will
define (hr ‘PPIOiiuis.ir wOudluip lot iii,
term, of rrm(,icthnn liv
1k) Adventisin 5 lfirmt’,uj,uih
PU lilge iuuhy 3 i9l , 40 P11 111
Au, I, isle; 40 P 11 hall, Au, Ii , illS ui-v
mmn,mird . ii PR slp , r b 0, utui
i’! II Cth(tti 5 In 1 i ” ,iuhm,i ,ihn 5 , , .( •
measfinshul, .d,, uu, •fl,u.,
I ) Crffe,ja fo, I’ ’sanrr of No(l of
l i st I to Deny C iiccf
Rqpi ruSio, or 1t hold a Il Snq
(I) I ’, un-ipfI 0 1 u, (11 A I Chuih la , pr .
•Lutnpti auth utnimr (list a ustire of
In( nt t heny rcpi,t, 1 , p s.uitni( to
sectIon 3 )I ) of (lit Act, noting’ of
Intent to ticci reyhitrail us Pl m ralucum(
to section bx() of (I Au-I, or a
notice of Inst it to lioh a tieuuiiiip lo
determine *1 (tier I e irjiuui,mhlon
Should bt t*OL lied denied a-a ep-
Propniate, audi timed, upon a lie.
(er,nInm(i 0 1 , by (I tlmmIiflh ,t,uito , (hat
the pe uticid. Intel or i’PctetJ coy of
(lie eiiterl 5 for rIck t lot (Ii In par c-
Irephi ( cX3) of (/ h , a liori, hJi’oti lu au-lu
detefnitnatlonj (lit Admi,uhuh,alo,
simmhi Ilium flç(ice by c ti(ieti mmdl to
(lie appi(c ,rulflr nepiutra t, L ’ u thur cmi,
mcy be. ( (pun 5 (intL (lie Pl’lirsuut or
ne,istrent 1 lit, time °h’l’ (hull p io
subunit Iudence imi tehiumlu of inch,
PnieUun$lon in •ccoumhauuce ihi 1dm
•IlPtifui)I4) of Liii,, preuhomi 1I e cppui
usrut ph’ nepht(r., tiuvil have hmh(y live
I l )/Jsy. liohmi lime ti,il e siuchu mu,I i ,-m. I,
lCm), to •uulouu(t tvigirum, e hmi itiusmi ) i of
uifrmiiiii,;tlu,u. m.im’ni 5rui ilovilj u-n,
Choph.r I”iflVii oflm smil .,I P’tlscihoms A,.ncv
-------
•• . .I ( tS 111.*ni .11 •.I •.s $
• I”I,i
as s..lss( l .US5$ 5
C AIDS 50 ’ .
I I• dI9hI%I l l aS ‘1 •I&$ *nsI$
aI . SC ‘I On C••I ..ç a
•.a ‘nos
I, ICIOl,$ On m l
r;g II • Al (S AI$lI l(AlIflhI
• — • •. .* b. b .
.— .-. .4•• •4 • _ .. .
—.. ..b
It • in. 11*111.11,1
.• .. .
€1
5tOIIAG(E MiO
lO t)I WO’At.
S’alnati _______________
sI, , I ’ s ’s ______________________
‘‘ p.
cn —
Cnn. — ___________
_ I
(no .. —
( I’O ’
-v-----------
flna,, 5,$l ,Il(. 1 •aI
• .. .1...... . .
P1 ODUCT
NAME
...;i.. . •••l•s•.. .s ..
*(IIv I •.flnSDh ’ I _________________
• l’ I — —
101*1 . jiisw,
111*1 rA5p’p p 5 (0UI*•a$ I I Iii Sin II ’SIO ,S (3(i )
K1E,’ our or hEAd 101: cim i)IiiE l
CAUTION
1IAl(la . 0, ••lI’’:Ii:aS I s as.s.as
• ____________________ ______
* .1” Is (fl — -
V O . •$ . ii - — — - . _____________
• II S ‘S I ____________________
Si, $l , p liast I Ofl ‘IIflt IW)l.a% Ifl5 C *5II(Ia ,a.I, $ 1*111.11111
&aI (5 fl • ___________
I O . 4 a. s p — _______ -
J\I 5 1 flalj .. . , 5aaI ‘ .45 — ______ . .
$r =—- —(. I
P. 55 (I),I 5 ,.I,—— -_— ___.__________ I
-------
P t l*UDly ItAISUINt
IS AioS.r.&.i.
SIOI1AOE AND
DISPOSAL
11011*0 1 - —
1
‘PRODUCT
NAME
AWP4 SKti’IDSNI —
$ 59 5 5 __________________
100 00
1111 PflOt sj 5 cOlitAlls a, o. pi O.AL(014
to-
KEEP OUT OF (lEACH OF C (IILtrnEU
DANGEfl —POISON
V 1wAi o o
V
V 014 l’
V =
SIA ISMS,iI O PPIAcI1 *. 5 IJ I IAIM IN,
I II 11 ) 4 PAlilt. Dot At s1r 1AL PpICAI.tviw*itv IIAIlLa( i,
(1 ________________
I 1IRAhI),Iu IiIJ ho ________________
IPAflhI It.I*Il).. h,o _________
I 11(1 CO’ht(i Ii _______________
—
PP ICAUI.rjrnpy SIAPIUSNIS
hI*jSJlI)1 SO SIUUAu I
IS flOut tlU AN IA(
bANOD P
li.vv 0hluIh.IA( hI&jAhp$
• flESTflICTEIJ USE
PESTICIDE
hr rst,II tile It t1 sit • , I (..tItI• ‘pp lli,I,.,
“ FerI. S psi ,, (ii, dI..i I Su i.r.t.I,s e •.5, f.r
I •iI cC ,, i.,p,.4 I, S . tar%II 5.4 ipplIt ,i., 5 (. ,IIiI—
ISils is
fl’ 1cIS:1.IS POll U,S
• I b. b i
._ .._. ..i S
..— ‘S
cI —
‘-S
loll’
I
ii
-------
APPI 29DIX IV-2
LABELINO REQUIREM1 NFS OP THE FIFRA, AS AMD 1DED
Keep Out of Reach
of Children
(Child hazard
warning)
Above signal
word
Thined Lately
tie Iow child
hazard
wnrtilrig
rri ii
LABEL EW1J NF
APPLICABILITY
OF iUIithN
PLACE1IE 1 ON LABEL
COMMFM’S
REX UIRFI)
PREFERRED
1
Product name
All products
Front panel
Center front
panel
2
Company name
and address
All products
None
Bottom front
panel or end
of label text
If registrant is not the producer, must
be qualified by “Packed for . . •,“
“Distributed by. . .,“ etc.
3
Net contents
All products
None
Bottom front
panel or end
of_label_text
May be in metric units in addition to
U.S. units
1
EPA Beg. No.
All products
None
•
Front panel
Must be in similar type size and run
parallel to other type.
5
EPA Eat. No.
All products
None
Prdnt panel,
itmiedlately
before or
following
Beg._No.
May appear on the container instead of’
the label.
6A
Ingredients
statement
All products
Front panel
Ininediately
following
product name
Text must run parallel with other text
on the panel.
6B
Pounds/gallon
statement
Liquid products
where dosage
given as lbs.
al/unit area
Front panel
Directly below
the main
ingredients
statement
.
7
Front panel
precautionary
statements
All products
Front panel
All front panel precautionary statements
must be grouped together, preferably
blocked.
( A
all products
711
Signal word
l?ront panel
Front anel
NOte type size requirements.
Note type size requirement3.
-------
APPE 4DIX P1-2 (contthued)
JTj1j }%
LABEL EWIEIIT
APPLICABILITY
OF REX IJIRE}1FNP
PLACEME ’TP ON lABEL
COMME2’ITS
REY )UIRED
PREFERRED
7C
Skull & Cr038—
bones and word
FOISON (in red)
All products
which are Cat-
egory I based
ono 1 ,der—
mal, inhala-
tion__oxicity
Front panel
Both in clo3e
proximity to
signal word
7D
Statement of
practical
treatment
All prodUCtB
in Categories
I, II , and III
Category I:
Front panel
unless refer-
ral statement
13 used.
Othera:
Grouped with
side panel
precautionary
statements.
Front panel
for all.
7E
Referral
statement
All products
where pre-
cautionary
labeling
appears on
other than
front_panel.
Front panel
8
Side/back panel
precautionary
statements
All products
None
Top or side
of back panel
preceding
directions
for_use
Must be grouped under the headings in
UA, BB, and 8C; preferably blocked.
8A
Hazards to All products
humans and in Categories
domestic I, II, and HI
animals -- -.1
Erivlroraieutal L 3 . pro ’
hazards
None
Same as above
Must be preceded by appropriate signal
word.
8 1 1
None
Same as above
Erivlrorunental. hazards Include bee
caution where applicable.
-------
APP 4DIX IV-2 (continued)
ITI 24
LABEL ELE}1ENT
APPLICABILITY
OF REL UIREMENf
PLAC 74E] T ON LABEL
COMMENPS
REX tJIflEI)
PREF1 ]1RED
8c
Physical or
chemical
hazards
All pressurized
products, others
with flash
points under
150°F
None
Same as above
9A
Restricted
block
All restricted
products
Top center
of front
panel
Itrinedlately
following
heading of
direc tibns
foruse
Preferably
blocked
Includes a statement of the terms of
restriction. The words h,RESnI1tICTEI) USE
PESTICIDE” must be same type size as
Bignal word.
9C
Misuse
statement
All products
I
1OA
Reentry
statement
All
choithesterase
inhibitors
In the
directions
for use
linnediately
after misuse
statement
1OC
Storage and
disposal block
All p ‘oducts
In the
directions
for use
Iranediately
before
specific
directions
for use or
at the end of
directions
for use
Must be et apart and clearly distth—
guiehable fran from other directions
for use.
1OD
Directions
for_use
All products
None
None
Ma.y be in metric as well as U.S. units
-------
Appendix IV-3
PHYSICAL-CHEMICAL HAZARDS
Criteria
Required Label Statement
I. Pressurized Containers
A. Plashpoint at or below
20°F; or if there is a
flashback at any valve
opening.
B. Flashpolnt above 20°F
and not over 80°F; or
if the flame extension
is more than 18 inches
long at a distance of
6 inches from the
valve opening.
C. ALL OTHER PRESSURIZED
C ONTAINERS
II. Non—Pressurized Containers
A. Flashpoint at or below
20°F.
B. Flashpoint above 20°F
and not over 80°F.
C. Flashpoint over 80°F
and not over 150° ?.
D. Flashpolnt above
150°F.
Extremely flammable.
Contents under pressure.
Keep away from fire, sparks,
and heated surfaces. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat, sparks, and flame. Do
not puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces.
Flammable. Keep aw .y from
heat anc cen f1a E
Do not use or sto’e near
heat and open flane
None required.
101
-------
Appendix IV-L
STORAGE AND DISPOSAL INSTRUCTIONS FOR PESTICIDES
All products are required to bear specific label instructions
about storage and disposal. Storage arid disposal instructions
must be grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL. Products
intended solely for domestic use need not include the heading
“STORAGE AND DISPOSAL.” The STORAGE AND DISPOSAL heading
must appear in the minimum type size listed below:
Required type size
Size of label for the heading
front panel in STORAGE AND DISPOSAL
square inches (all capitals)
10 and under . . . . . . . . . . . . . . .6 point
Above 10 to 15 . . . . .8 point
Above 15to 30 . . . . . . . . . . . . . 10 point
Over 30 . . . . . . . •. . . 12 point
Storage and disposal instructions must be set apart and
clearly distinguishable from other directions for use.
Blocking storage and disposal statements with a solid line is
suggested as a means of increasing their prominence.
A. Storage Instructions :
All product labels are required to have appropriate storage
instructions. Specific storage Instructions are not prescribed.
Each registrant must develop his own storage instructions 1
considering, when applicable, the following factors:
1. Conditions of storage that might alter the cornTsition or’
usefulness of the pesticide. Examples could te temperature
extremes, excess! e moisture or humidity, heat sunlight,
friction, or co .t iinating substances or medi.
2. Physical requirements of storage which might ad tersely
affect the container of the product and its ab’.lity to
continue to function properly. Requirements might include
positioning of the container in storage, storage or damage
due to stacking, penetration of moisture, and ability to
withstand shock or friction.
3. Specifications for handling the pesticide container,
including movement of container within the storage area,
proper opening and closing procedures (particularly for
opened containers), and measures to minimize exposure
while opening or closing container.
102
-------
Appendix IV-LI
(continued)
LI. Instructions on what to do if the container is damaged in
any way, or if the pesticide is leaking or has been
spilled, and precautions to minimize exposure if damage occurs.
5. General precautions concerning locked storage, storage in
original container only, and separation of pesticides
during storage to prevent cross—contamination of other
pesticides, fertilizer, food, and feed.
6. General storage instructions for household products should
emphasize storage in original container and placement in
locked storage areas.
. Pesticide Disposal Instructions :
The label of all products, except those intended solely for
domestic use, must bear explicit instructions about pesticide
disposal. The statements listed below contain the exact wording
that must appear on the label of these products:
1. The labels of all products, except domestic use, must
contain the statement, “no not contaminate water, food,
or feed by storage or disposal.”
2. Except those products intended solely for domestic use,
the labels of all products that contain active ingredients
appearing on the “Acutely Hazardous” Commercial Pesticide
Products List (RCRA “E” List) at the end of this appendix
or are assigned to Toxicity Category I on the basis of
oral or dermal toxicity, skin or eye irritation potential,
or Toxicity Category I or II on the basis of acute inhala-
tion toxicity must bear the following pesticide disposal
statement:
“Pesticide wastes are acutely hazardous. Improper dis-
posal of excess pesticide, spray mixture, or rinsate is
a violation of Federal Law. If these wa es cannot be
disposed of by use according to label i.n cructions,
contact your State Pesticide or Environri ntal Control
Agency, or the Hazardous Waste representative at the
nearest EPA Regional Office for guidance “
The labels of all products, except those intended for
domestic use, containing active or inert ingredients
that appear on the “Toxic” Commercial Pesticide Products
List (RCRA “F” List) at the end of thiS appendix or
presently meet any of the criteria in ubpart C, L O CF
261 for a hazardous waste must bear the followIng pesticIde
disposal statement:
103
-------
Appendix IV-L
(continued)
“Pesticide wastes are toxic. Improper disposal of excess
pesticide, spray mixture, or rinsate is a violation Of
Federal Law. If these wastes cannot be disposed of by
use according to label instructions, contact your State
Pesticide or Environmental Control Agency, or the Hazardous
Waste representative at the nearest EPA Regional Office
for guidance.”
Labels for all other products, except those intended for
domestic use, must bear the following pestlcide disposal
statement:
“Wastes resulting from the use of this product may be
disposed of on site or at an approved waste disposal
facility.”
3. Products intended for domestic use only must bear the
following disposal statement: “Securely wrap original
container in several layers of newspaper and discard in
trash.
C. Container Disposal Instructions
The label of each product must bear container disposal
instructions appropriate to the type of container.
1. All products intended for domestic use must bear one
of the following container disposal statements:
Container Tv e Statement
Non—aeroso1 products
(bottles, cans, jars)
Do not reuse container (oottle, can, jar).
Rinse thoroughly before discarding in trash.
Non—aerosol procucts
(bags)
Do not reuse bag. Discard bag in trash.
Aerosol products
Replace cap and discard containers in
trash. Do not incinerate or puncture.
1OL
-------
Appendix IV-Z4
(corit inued)
2. The labels for all other products must bear container disposal
instructions, based on container type, listed below:
Container T e
Statement
1, Manufacturer may replace thIs phrase with one indicating
— whether and how fiber drum nay be reused.
Metal
containers
(non—aerosol)
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
a.nd dispose of in a sanitary landfill, or by
other procedures approved by state and local
authorities.
Plastic containers
Triple rinse (or equivalent) . Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or
incineration, or, if allowed by state and
local authorities, by burning. If burned,
stay out of smoke.
Glass containers
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved_state_and_local_procedures.
Fiber drums
with liners
Completely empty liner by shaking anc
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
reused l,_dispose_of_in_the_same_manner.
Paper and
plastic bass
Completely empty bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning. If burned, stay
out of smoke.
Compressed gas
cylinders
Return empty cylinder for reuse (or
similar wording)
135
-------
Appendix IV-LI
(continued)
Pesticides that are hazardous wastes under 40 CFR 261.33(e) and (f)
when discarded.
“ Acutely Hazardous” Commercial Pesticides (RCRA “E” List)
Active Ingredients, (no inerts) ;
Acrolein
Aldicarb
A 1. d r in
Allyl alcohol
Aluminum phosphide
Z —Aminopyridine
Arsenic acid
Arsenic pentoxide
Arsenic trioxide
Calcium cyanide
Carbon disulfide
p—Chloroani.line
Cyanides (soluble cyanide salts, not specified elsewere)
Cyanogen chloride
2—Cyclohexyl—LI ,6—dinitrophenol
Dieldrin
0,0—Diethyl S— [ 2—ethylthio)ethyl] pkiosphcrodithioate
(disulfoton, Di-Syston)
0,0—Diethyl 0—pyrazinyl phosphorothioate (Zinophos)
Dimethoate
0,0—Dimethyl 0—p—nitrophenyl phosphorothioate (methyl parathion)
L I,6 —Dinitro—o—cresol and salts
LI ,6—Dinitro—o—cyclohexylphenol
2,LI Dinitrophenol
Dinoseb
Endosulfan
Endo thall
Endrin
P amphu r
Pluoroacetamide
Heptachior
Hexanethyl tetraphosphatE
Mydrocyanic acid
Hydrogen cyanide
Me thorny 1
alpha—Naphthylthiourea (ANTU)
Nicotine and salts
Octamethylpyrophosphoraiaide (OMPA, schradan)
Parathion
106
-------
Appendix IV-L
( continued)
“ Acutely Hazardous” Commercial Pesticides (RCRA “E” List)
Active ingredients coritinuec :
PhenylmerCUriC acetate (PMA)
Pho rate
Potassium cyanide
Propargyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacetate
Strychnine and salts
0,0,O,O—TetraethYl dithiopyrophOsPhate (sulfotepp)
TetraethYl pyrophosphate
Thallium sulfate
Thiofanox
Toxaphene
Warfarin
Zinc phosphide
107
-------
Appendix IV—L
(cont iriued)
“ Toxic” Co ercial Pesticide Products (RCRA “F” List)
Active Izi redjents :
Acetone
Acry lonit rile
Arni. t role
Benz ene
B13( 2—ethylhexyl)pthalate
Cacodylic acid
Carbon tetrachioride
ChloraJ. (hydrate)
Chiordane (technical)
Chlo roberizene
4—Chloro— —cresol
Chiorotorm
o—Chlorophenol
1 —Chloro—o—tojujdine hydrochloride
Creosote
Cresylic acid
Cyclohexane
Decachlorooctahydro_l,3,L _ etheno_2H_cyc1obuta [ c,dJ...pentalen_ 2 _one
(kepone 1 chiordecone)
l,2—Dibro o—3—ch1oropropane (DBCP) —
Dib ityl phthalate
S—3,3—(Dichloroallyl diizopropy1thiocarb ate (diallate, Avadex)
o—Dichlorobenzene
p—Dichlorobenz ene
Dichlorodifluoromethane (Freon 12)
3,5—Dichloro—N—(l,l—dimethyl—2—propynyl) benza.mide (pronami.de,Xerb)
Dichioro diphenyl dichioroethane (DDD)
Dichioro diphenyl trichioroethane (DDT)
Dichiorethyl ether
2 , 4 —Dichlorophenoxyacetic, esters and salts (2,4—D)
1, 2—Dichioropropane
l,3—Dichloropropane (Telone)
Dimethyl pht late
Ethyl acetate
Ethyl 4 1 1 4’—U ..chlorobenzi1ate (chlorobenzllate)
Ethylene dibro ide (EDE
Ethylene di c1 lor1de
Ethylene o’ ide
Formaldehyde
Furfural
iexachlorobeizene
Hexachiorocyclopentadiene
exachloro hane
Hydrofluoric acid
108
-------
Appendix IV- 4
(continued)
“ Toxic” Commercial Pesticide Products (RCRA “F” List)
Active Ingredients :
Isobutyl alcohol
Lead acetate
Lindane
Maleic hydrazide
Mercury
Methyl alcohol
Methyl bromide
Methyl chloride
2,2’—Metkiylenebiz (3,L ,6—trichlorophenol) (hexachiorophene)
Methylene chloride
Methyl ethyl ketone
i4— ’1ethyl—2—pentanone (methyl isobutyl ketone)
Naphthalene
Nitroberizene
p—Ni trophenol
Pentachioroethane
Pentachloronitrobenzene (PCNB)
Penta.clorophenol
Phenol
Phosphorodlthioic acid, O,O—diethy1 methyl ester
Propylene dichioride
P yr i d the
Resorc inol
S af role
Selenium disulfide
Silvex
1,2, L , 5—Tetrachlorobenzene
1,1,2k 2—Tetrachioroethane
Tetrachioroethylene
2,3, , 6—Tetrachiorophenol
Thi.ram
Toluene
1,1, l—Trichloroethane
Trichlo 1 ’oethylene
Trichl. L’omoncfluoromethane (Freon 11 )
2, , 5—TrlchJ.orophenol
2, , 6—Trichlorophenol
2,L ,5—Trichlcrophenoxyacetic acid (2, ,5—T)
Xy lelie
109
-------
Appendix IV- 4
(continued)
“ Toxic” Commercial Pesticide Products (RCRA “F” List)
Inert Ingredients :
Acetone Formaldehyde
Acetonitrile Formic acid
Acetophenone Iso utyl alcohol
Acrylic acid Meleic anhydride
Aniline Methyl alcohol (methanol)
Benzene Methyl ethyl ketone
Chlorobenzene Methyl methacrylate
Chloroform Naphthalene
Cyclohexarie Saccharin and salts
Cyclohexanone Thiourea
Dlchlorodifluoromethafle (Freon l2) Toluene
Diethyl phthalate 1,1,1—Trichioroethafle
Dimethylamine 1,1, 2—Trichloroethane
Dimethyl phthalate TrichioroflUOromethane (Freon il’)
l, —Dioxane Vinyl chloride
Ethylene oxide Xylene
110
------- |