Untted StitM
Environmental Protection
Agency
Off ice of
Pesticides end Toxic Substance*
Washington DC 20460
Pesticides
&EPA
"Wrch 1985
Guidance for the
Reregistration of
Pesticide Products
Containing Pendimethalin
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GUIDANCE FOR THE
REREGISTRATION OP PESTICIDE PRODUCTS
CONTAINIMG
PENDIMETHALIN (108501)
EPA CASE NUMBER: 187
CAS: 40487-42-1
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20460
MARCH, 1985
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TABLE OF CONTENTS PAGE
Introduction .... 1
I. Regulatory Position and Rationale 4
II. Requirement for Submission of Generic Data 34
III. Requirement for Submission of Product-Specific
Data 64
IV. Submission of Revised Labeling 64
A. Label Contents 65
B. Collateral Information 70
v. Instructions for Submission 71
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APPEND ICES
1 1—1 Guide to Bibliography . . . . . . . . . . . .
11—2 Bibliography
11—3 FIFRA 3(c)(2)(B) Summary Sheet — EPA Form 8580—1
11—4 Certification of AttemPt to Enter Into an Agreement
with Other Registrants for Develooment of Data
EPA Form 8580—2 . . . . . . . . . . . . . . • •
i ll—i Product Specific Data Report (End—rise Products)
tv—i 40 CFR 162.10 Labeling Reguirements . . . . . .
Iv—2 Table of Labeling Requirements. . . . . . . . .
IV—3 Physical/Chemical Hazards Labeling Statement. .
IV—4 Storage and Disposal Instructions
ii
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INTRODUCT ION
The Federal Insecticide, Fungicide, and Rodenticide Act
(FIFRA sec. 3(g)) directs EPA to reregister all pesticides as
expeditiously as possible.
To carry out this task, EPA has established the Reqis—
tration Standards program, which will review all pesticide
products containing active ingredients first registered before
January 1, 1977. Pesticides will be reviewed in use clusters
which have been ranked to give earliest review to pesticides
used on food and feed crops.
The Registration Standards program involves a thorough
review of the scientific data base underlying pesticide
registrations and an identification of essential but missino
studies which may not have been required when the product
was initially registered or studies that are now considered
insufficient. EPA’S reassessment results in the development
of a regulatory position, contained in a Registration Standard,
on each pesticide and its uses. The Agency may require the
registrant to modify product labels to provide additional
precautionary statements, restrict the use of the pesticide•
to certified applicators, provide reentry intervals, modify
uses or formulation types, specify certain packaging limitations,
or other requirements to assure that proper use of the pesticide
will not result in adverse effects on the environment.
The scientific review, which is not contained in this
Guidance Package but is available upon request, concentrates
on the technical grade of the active ingredient and identifies
missing generic data. However, during the review of these
data we are also looking for potential hazards that may be
associated with the end use (formulated) products that contain
the active ingredient. If we have serious concerns, we will
address end use products as part of the Registration Standards
program and will propose regulatory actions to the extent neces-
sary to protect the public.
EPA has the authority under FIFRA Sec. 3(c)(2)(B) to
require registrants to submit data that will answer our
questions regarding the hazard that may result from the
intended use of a pesticide. Although Sec. 3(c)(2)(B) provides
that all registrants are responsible for these data, the
Agency generally imposes generic data requirements only on the
registrants of the manufacturing use products (basic suppliers
of the active ingredient). End use producers who
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do not qualify for the formulator’s exemption* are also
required to submit these data.
An end use producer who wishes to aualify for the formu—
lator’s exemption may change his source of supply to a reqistered
source, provided the source does not share ownership in
common with the registrant’s firm. An end use registrant
may do so by submittina a new Confidential Statement of
Formula, EPA Form 8570—4, identifying the registered sour e
of the active ingredient, to the appropriate Product Manager
within 90 days of receipt of this Guidance Document. The
chart on the following page shows what is generally requized
of those who do and do not qualify for the formulator’s
exemption in the Registration Standards program.
If you decide to request the Agency to cancel the regis-
tration of any of your products sublect to the reguirement s
of this Guidance Document, please notify the Product Manac er
named in the cover letter, within 90 days from the receipt
of this document. If you decide to maintain your product
registration(s), you must provide the information describ d in
the follqwing pages within the timeframes outlined. EPA wi ll
issue a notice of intent to cancel or suspend the reqistr tion
of any ci. rrently registered product which does not comply
with the requirements set forth in this Guidance Document,
You are reminded that FIFRA sec. (a)(2) requires you to
submit factual information raisinq concerns of possible
unreasonable adverse effects of a pesticide. You should
notify the Agency of interim results of studies in proare s
if those results show possible adverse effects.
*The formulator’s exemption applies to a registrant of an
end use product if the source of his active ingredient(s):
(1) is registered product and (2) is purchased from a sourice
which does not have ownership in common with the reqistrazit’S
f i rut.
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I PRODUCTS SUBJECT TO THE ACTION(S) REOUIRED TO
I REGISTRATION STANDARDS PROGRAM MAINTAIN RFGISTRATION
II. Products That Do Not Qualify
I For The Formulator’s Exemption
I A. Single Active Inaredient I These products must he reregis— I
Products* I tered. To obtain reregistration,J
I I labeling, packaqing and data
I I requirements must be satisfied I
I I in accordance with the Regis— I
I I tration Standards Guidance
I I Document. I
I..... .. .... . .. .... . ... . . ... 1....... •........ .... I •Is •e .... .... I
I B. Multiple Active Ingredient I These products will not be
I Products I reregjstered at this time.
I I However, generic data required I
I I to continue the registration of I
I I the active ingredient under
I I review, as described in the I
I I Registration Standards Guidance I
I I Document, will be required and I
I I some labeling precautions may I
I also be reauired. I
I ________________________ _______________________ I
II. Products That Do Qualify For I
The Formulator’s Exemption
I I
I I
I I
I I
I I
I I
I I
* End use products of registrants who also produce a manufacturing
luse product will not be required to be reregistered provided that
Iregistrant fulfills the requirements specified in the Guidance
IDocument for manufacturinq use product(s). Such end use oroducts
Iwill he subiect to the labelinq changes required for products in “II”
labove. If there are no manufacturing use products registered by any
Icompany end use products will be required to be rereqistered.
INOTE: If all registrants in “I” above fail to meet the requirements in,
lI—A and B above, then the registrants in “II” lose their riaht to I
qualify for the formulator’s exemption and become subject to the
Ireauirements in I—A and B.
Only when additional restric— I
tions or labeling are needed to I
protect man or the environment I
will these products be subject
to the Registration Standard I
requirements. Affected products I
will be dealt with in a variety I
of ways, including but not I
limited to the Label Improvementl
Program and special intent I
to cancel notices.
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I. REGULATORY POSITION AND RATIONALE
A. INTRODUCTION
This Reqi ration Standard describes the regulatory Position and
rationale of the Environmental Protection Agency (“the Agency’ t )
for all registered manufacturing—use products (MPs) and end—use
products (EPs) containing pendimethalin as the sole active in-
gredient. The Aaencv bases its position and rationale on an
evaluation of all MPS and Section 3, 24(c) and intrastate uses
registered for pendimethalin. EPs are reviewed only when there
are no MPs registered or when the label has been changed signifi-
cantly from the current accepted label. Mixtures are included
only when there is a significant change in the label. After
briefly describing the chemical and its uses, this chapter pre-
sents the Agency’s regulatory position and rationale, the criteria
for registration, acceptable ranges and limits, labeling require-
ments and the tolerance reassessments.
B. DESCRIPTION OF CHEMICAL
Pendimethalin is the accepted common name for the compound: N—(l-
ethylpropyl)—3,4--dimethyl—2,6--dinitrobenzenamine as determined
by the British Standards Institution, International Organization
for Standardization, and the Weed Science Society of America.
pendiinethalin is marketed under the trade name Prowl® and other
names such as: Herbadox®, Stomp®, and AC 92553. The Chemical
Abstracts Service (CAS) Registry number is 40487—42—1. The
Office of Pesticide Program’s EPA Chemical Code Number is 108501.
Pendimethalin is crystalline at room temperature and has a fruit—
like odor. The empirical formula is C 13 R 19 N 3 0 4 , and its molecular
weight is 281.30. The boiling point is 330°C. Pendimethalin is
soluble in aromatic and chlorinated hydrocarbon solvents: and in
water (at 20°C) to <0.50 ppm.
Pendimethaljn is a dinitroaniline herbicide which selectively con-
trols certain broadleafed weeds and grassy weed species. Pendi—
methalin is mainly applied as a preplant incorporation (except in
corn, rice and sorqhum), preemergence spray (corn, soybeans),
early postemergence (rice), and late postemergence “culti-spray”
(field corn and sorghum) applications.
Pendimethalin is taken up by the roots and shoots whereby it in-
hibits cell division and cell elongation. It is not readily
translocated from one part of the plant to the other.
Pendimethalin was patented by the American Cyanamid Company
(W.German Patent Nos. 2232—263 and 2241—408) in 1972 and was
first registered for use in 1974. Technical pendimethalin is
being produced in the United States by the American Cyanamid
Company of Princeton, New Jersey.
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Pendimethaliri is available as a technical material at 90.0 %
active ingredient for formulation of pendimethalin end—use products.
Pendimethalin is available in granular, dispersible granular, and
emulsifiable concentrate formulations.
C. REGULA RY POSITION AND RATIONALE
Based on the review and evaluation of all available data and other
relevant information on pendimethalin the Aqency has made the
following determinations:
1. The available data do not indicate that any of the risk
criteria listed in § 162.11(a) of Title 40 of the tJ.S.Code
of Federal Regulations have been met or exceeded for the
uses of pendimethalin at the present time.
Rationale: Pendimethalin is not acutely toxic by the oral,
dermal, inhalation and occular routes of exposure. The 2—
year dog feeding study satisfied the reauirement for a sub—
chronic dog study. The 2-year dog feeding study indicated
that dogs dosed with pendimethalin at 12.5 mq/kg, 50.0
mg/kg and 200.0 mg/kg had increases in alkaline phosphatase
level and liver weight. The NOEL is 12.5 ma/kg/day. A
teratology test in rats has shown that doses of pendimethalin
up to 500.0 mg/kg, highest dose tested (HDT), failed to
induce teratoqenic, or fetotoxic effects. A teratology
test in rabbits has shown that pendimethalin tested at 60.0
mg/kg (HD’r), failed to induce teratoqenic or fetotoxic
effects. A reproduction study (3—generation rat) indicated
that pendimethalin tested at 500 ppm to 5,000 ppm induced
slightly reduced number of offspring, with no corresponding
increase in deaths; decreased weiqht gain from weaning to
maturity. The NOEL is 500 ppm.
The following toxicological data gaps are: a dermal sensiti-
zation study in guinea pig, a 90—day rat feeding study, a
chronic toxicity study in rat, an oncogenicity study in rat
and in mouse, and the mutagenicity tests: gene mutation in
bacteria, gene mutation in mammalian cells in culture,
chromosomal aberration analysis in mammalian cells in cul-
ture, and DNA damage in mammalian cells in culture. There
are also extensive residue chemistry and environmental
fate data gaps.
2. The Agency will not allow any significant new uses* to be
established for pendimethalin until the toxicological and
residue chemistry data deficiencies identified in Table A
have been satisfied.
* “Significant new use” is defined in 44 FR 27934, May
11, 1979. In the case of a new food or feed use, the
Agency will qenerally consider as significant an in-
crease in the Theoretical Maximum Residue Contribution
of greater than 1%.
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Rationale: The Aqencv is unable to complete a tolerance re-
assessment of oendimethalin because of extensive residue
and toxicology data gaps. The data requested in Table A
are needed for EPA to evaluate the metabolism of pendi-
methalin and related metabolite(s) in crops and animals,
storage stability, and chronic studies in the rat and mouse.
3. Products which are substantially similar to reaistered pro-
ducts may be considered for registration, subiect to the
terms and conditions specified in this document.
Rationale: The Agency does not think that new registrations of
uses already on the market will increase the risks to the
public from exoosure to pendimethalin. However, the Agency
will not register new products that would significantly in-
crease exposure until the data qaps have been filled.
The Agency has authority under FIF’PA Sections 3(c)(2)(R),
3(c)(5) and 3 (c)(7) to reauire registrants and applicants
for registration to provide data needed to support new or
existinq registrations. The issuance of this registration
standard is the mechanism which the Agency has chosen to
identify such data. These data will be reviewed and evalu-
ated when they are received. At that time, the Agency will
determine how the data will affect the registration(s) of
pendimethalin.
4. The Agency will required MPs containing pendimethalin to
bear Category III hazard statements and other warning
statements as required in the precautionary labeling under
40 CFR 162.10.
Rationale: Acute toxicity studies for pendimethalin showed
the following: Toxicity Cateqory III for acute oral and
dermal toxicity, and for dermal and Primary eye irritation,
and Toxicity Category IV for acute inhalation toxicity.
S. The Agency is requiring monitoring data for potential
residues in aquatic sites next to rice fields. Once the
Aqency has evaluated these additional data, it will deter-
mine if EPA should impose more strinqent measures to mini-
mize exposure of aquatic organisms to endimethaiiri. For
the present, the Agency is requiring MPs and EPs con-
taining pendimethalin to bear revised environmental hazard
statements reflectjnq its toxicity to fish and aquatic in-
vertebrates (Refer to Section F. REOUIRF.T) L.ARFT TN(fl by
October 3fl, 1985.
Rationale: Ecological effect studies indicate that pendi—
methalin is highly toxic to certain coidwater and warmwater
fish: moderately to highly toxic to marine and estuarine
organisms. However, a detailed ecological hazard assess-
ment cannot he made until certain environmental chemistry
data requirements are fulfilled and a monitoring study of
aquatic sites next to rice fields is performed.
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6. The Slackwater darter and certain freshwater mussels are
endangered species at risk from the use of pendimethalin
on cotton. The Agency is addressing appropriate means of
labeling pesticides that may threaten the continued exis-
tence of endanqered species. The labelinq should be corn—
pleted by the 1986 growing season. If it is not, this
standard may be amended to impose interim labeling to
protect endangered species.
Rationale: The Agency believes that the conventional labeling
approach may be inadequate to properly inform the users on
how to protect the endangered species. The Agency antici-
pates that appropriate labeling will be developed in time
for the 1986 growing season for cotton.
7. The Agency will regulate the current level of nitrosamine
contaminant in technical oendimethaliri. Technical pendi—
methalin may contain the N-nitroso contaminant, N—nitroso-
pendimethalin at a limit not to exceed 60 ppm. Other
contaminants must be analyzed.
Rationale: A risk assessment was performed usiriq surroqate
data from diethyl—N—nitrosamine (DEN), the most hazardous
known N—nitroso contaminant, and indicated if the nitroso
contaminant in technical pendimethalin was not in excess
of 135 ppm, the associated upper risk would not exceed 1
x l0 (1/1,000,000). As of August 1980, the manufacturing
process was modified to reduce the amount of N—nitrosO—
pendimethalin formed during the production of technical
pendimethalin. Data submitted to the Agency have shown
that the level of this contaminant is less than 60 p m in
the technical product produced at the present time.
Registrants are required to submit product analysis data
and to certify what amount of the active ingredient and any
impurities, including N—nitroso—pendimethalirl, will be
present in technical pendimethalin.
8. The Agency is imposing restrictions on rotational crops and
irrigated crops. The extent of the restrictions will be
reconsidered when additional data are received.
Rationale: It is the policy o the Agency to impose restric-
tions on planting rotational crops and use of water from
treated fields for irrigation of crops, pendinq the sub-
mission of data. This serves to protect the public from
impermissable residues in food or feed in subsequently
planted croPs due to persistent residues.
9. The Agency has determined that pendimethalin should not cause
a water contamination problem. Therefore, the Agency will
not impose qround water data requirements on pendimethalin.
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10. The Agency is not requiring a re-entry interval for currently
reqistered uses of pendimethalin at this time.
Rationale: Pendimethalin has low acute toxicity (Cateaory ITT)
and no known chronic effects at the present time.
11. Reqistrants of end-use products must submit revised lahelina
which incorporates the label precautions found in Section F.
Rationale: The Aqency believes that label statements prescribed
in this guidance document should minimize the hazards to
certain coidwater and warmwater fish, marine and estuarine
organisms.
D. CRITERIA FOR REGISTRATION UNDER THIS DOCUMENT
To he sublect to this guidance document, MPs must meet the fol-
lowing conditions:
1. Contain pendimethalin as the sole active ingredient and,
2. Conform to the acute toxicity limits, product composition,
and use pattern requirements listed in Section F of this
document.
Registration of products subiect to this document must comply with
all terms and conditions described in it, including commitment to
fill data aaps on a schedule acce tabie to EPA and consistent with
that required of the present registrant. All registrants and
applicants for registration under this document must follow the
instructions contained in this document and complete and submit
the appropriate forms within the specified time.
E. ACCEPTABLE RANGES AND LIMITS
1. Product Composition Standard
Technical grade products must contain at least 90.0 percent pendi-
methalin as the sole active inqredient. Each MP formulation
proposed for registration must be fully described with an appro-
priate certification of limits. In addition, the active ingredient
found in the MPs must be substantially similar to that in currently
registered technical products. Any MP not meeting these require-
ments will be considered a new oroduct and will not be registerable
under this guidance document.
2. Acute Toxicity Limits
The Agency will consider registration of products containing
peridimethalin, provided that the product labeling bear appropriate
precautionary statements for the acute toxicity category in which
each product is placed.
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2. Acute Toxicity Limits
The Agency will consider registration of products containing
pendimethalin, provided that the product labeling bear appropriate
precautionary statements for the acute toxicity category in which
each prod çt is placed.
3. Use Patterns
To be registered under this standard, MPs containinc pendimethalin
must be labeled for formulation only into end—use herbicide
products for the commodities listed below. The attached index
entry lists all registered uses, as well as approved maximum
application rates and frequencies.
pendirnethalin, a selective herbicide, is registered for control
of broadleaf weeds and grassy weed species on the followinq sites:
soybeans, cotton, field corn, beans, peanuts, potatoes, rice,
sorghum, sunflower, tobacco, ornamentals, non—bearing fruit and
nut crops, and vineyards. One site, loloba is registered under
Section 24(c) in Arizona.
F. REQUIRED LABELING
All technical grade products, MPs, and EPs containina pendi—
methalin must bear appropriate labeling as specified in 40 CFR S
162.10. Other portions of this guidance package contain specific
information regarding label requirements.
In addition to the requirements stated in 40 CFR S 162.10, the
following information must appear on the labeling no later than
April 30, 1986.
1. Ingredient Statement
The ingredient statement for MPs must list the active in-
gredient as:
pendimethalin, N-(1—ethylpropyl)-3,4—dimethyl— 2 i
—dinitrobenzenamine
2. Manufacturing—USe Product Statements
All products intended for formulation into end—use products
must bear the following statement:
“This pesticide is toxic to fish. Do not discharge effluent
containing this product directly into lakes, streams, ponds,
estuaries, oceans or public waters unless this product is
specifically identified and addressed in a National Pollutant
Discharge Elimination System (NPDES) permit. Do not dis-
charge effluent containing this product into sewer systems
without previously notifying the sewage treatment plant
authority. For guidance, contact your State Water Board or
Regional Office of the Environmental Protection Agency”.
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3. End—Use Product Statements
The human hazard statements must appear on all EP labels
as prescribed in 40 CFR 162.10. In addition, the following
environmental hazard statement must appear on all EPs:
a. Non Aquatic Uses (Granular products)
“This pesticide is toxic to fish. Do not apply directly
to water. Runoff from treated areas may be hazardous
to aquatic organisms in neighborinq areas. Do not
contaminate water by cleaning of equipment or disposal
of wastes. In case of spills, either collect for use
or dispose of properly”.
b. Non Aquatic Uses (Nongranular products)
“This pesticide is toxic to fish. Do not apply di-
rectly to water. Drift and runoff from treated areas
may be hazardous to fish in neighboring areas. Do
not contaminate water by cleaning of equipment or
disposal of wastes”.
c. Aquatic Uses (Rice)
“This pesticide is toxic to fish and aquatic organisms.
Fish may be killed at application rates recommended
on the label. Do not contaminate water by cleaning
of equipment or disposal of wastes”.
“Do not apply to rice fields if fields are used for
catfish or crayfish farming”.
Restrictions on Rotational Crops
“Pending the submission of rotational crop data, do not
apply pendimethalin on rice fields in which crayfish or
catfish farming are included in the cultural practices,
and do not plant crops in pendimethalin—treated fields
unless pendimethalin is registered for use on those
crops”.
Restrictions on Irrigated Crops
“Pending the submission of irrigated crop data, do not
use water containing pendimethalin residues from rice
cultivation to irrigate food or feed crops which are
not registered for use with pendimethalin”.
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G. TOLERANCE REASSESSM NT
The Acceptable Daily Intake (ADI) for oendimethalin was originally
based upo a 2—year feeding study on rats, which was subsequently
declared invalid. Subsequently, the Provisional Acceptable Daily
Intake (PADI) for pendimethalin was calculated, using the 90 day
portion of the same study. The subchronic oortion of this study
was used instead of a 2—year dog study because the (P)ADI value
calculated for the rat is the more conservative value on a mg/kg
basis than for the dog:
NOEL Safety (P)ADI (P)MPI
(mg/kg) Factor mg/kg/day mg/day (60 kg
Rat 25.0 2,000 0.0125 0.7500
Dog 12.0 100 0.1250 7.5000
The No—Observable—Effect-Level (NOEL) for the rat study is 25.0
mg/kg. A 2,000—fold safety factor was used and the PADI was
calculated as 0.0125 mg/kg/day with a Maximum Permissible Intake
(MPI) of 0.7500 mg/day for a 60 kg person. The Theoretical Maxi-
mum Residue Contribution (TMRC) for pendimethalin—based permanent
tolerances is 0.0166 mg/day for a 1.5 kg diet. Currently, the
permanent tolerances utilize 2.22 % of the PADI.
The Agency is unable to complete a full tolerance reassessment
because the available pendimethalin toxicology and residue data
do not fully support the established tolerances listed below.
The metabolism of pendimethalin in animals and plants is not
fully understood. Therefore, the Agency is requiring data on the
metabolism of pendimethalin and related metabolite(s) in crops
and animals, and on storage stability. Additional long term
rat and mouse studies are also required. The additional data
will be used to assess dietary exposure to pendimethalin and may
lead to revisions in the existing tolerances. Therefore, the
Agency will not grant any significant pending or new tolerances
for pendimethalin until the data are submitted.
In the United States, tolerances are currently established in 40
CFR S 180.361 for the combined residues of the herbicide, pendi—
methalin: N—(l-ethylpropyl)—3,4—dimethyl—2,6—dinitrObeflzeflamifle
and its metabolite: 4—(1-ethylpropyl)aminol-2-methyl—3,5- -dinitrO-
benzyl alcohol, in or on the raw agricultural commodities listed
below:
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Commodities
Parts per million
** Beans (lima, dry, snap) 0.1
** Beans, foraqe 0.1
** Beans, hay 0.1
Corn, fodder 0.1
Corn, forage 0.1
** Corn, fresh(includina sweet, T<+CWHR) 0.1
Corn, arain 0.1
Cottonseed 0.1
Peanuts 0.1
Peanut hay 0.1
Peanut foraqe 0.1
Rice grain o.oc
Soybeans 0.1
Soybeans, forage 0.1
Soybeans, hay 0.1
Sunflower seeds
** The tolerances for these commodities were established after the
science reviews for the pendimethalin registration standard
were completed.
International Tolerances
presently, there are no tolerances for residues of peridimethalin
in Canada, Mexico, or in the Codex Alimentarius .
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A Index to P sti 3e C rn 1S
L)LM ALfl * h 10850 1
‘2E ? T1CIDE: Herbicide, Pant uL t r
JLATO S:
Tech (90%)
C (1%, :0%)
EC (2. 8 ibj’l, 3 ib/f:al, 4 lb,/cal)
;i s L2 rAT:c s: r L etha1in controls ge Tninatiflg weeds;
ifl not a rtrol estabI shed. s. C€ strov existing weeds prior to
pi: tion. Cditior s that delay ger ir ation or extend it over a long
:d of t e y r - oe aontrol. uneven arplication or improper
.oi J .ar- Yon can re3 c -‘e’ d c ntroi or c. use crop injury. Onditi.Or.S
t -= n ic nd nts isc increase the ‘xnss ility of crop
- i . --:-‘ s a cu.t vatic’n or rrtsr.j >eLng wiil
‘ t r. &t i - ntrol. Pd aim aoc1iceti ns v be
.v :: :--d c de. :ic’uid fo tions - v -e ;r ’ ied
-‘-: ‘ J :r!. Pn a n : y be on dry
3 .r nt ::n r3z d pl c iior s. : ..
3 jf 5 il.k t l j-r th the
f - :- r -::e. Y ke rial L v5 n 5 : r C S Of
• . -r r . P -- e -f ;e :n pL-oç Drt on o ! nd ict.. elly treated.
T -. - .ay ;‘ :. o :tJ, r ci s t e f c ing year. winter eat
nd i:it r r y : . y e in the f i1 120 c a’jS after a ?endirnethaiin
‘ n1i: ti n -i nv roc. in iITic:at d do r ot pi ant winter wheat or
- -: : f 11 f crnp failure cx rs and the land is fa1i Qed
. r T •; c . y Suit. ‘o ot plant winter wheat
rtr-L - the 1l to trmted a ir no—tillage pr i — 3dreS
as r p rj : . y : s it. To not f3 far ge or graze livestoc) for 75 days
ft -r as : - - t or 5 r y in tre r.&d rces. To avoid crop injury, do
ot 1ant r d - ts or s i ach for 12 ironths folici ng
i ation.
rL ’E -c .i: D OR ( IO ’L: riot 1 - t ed.
?i\Y XiC 2Y O r.iS: Not located
MCDC OF CN: } rbicic 1 eff ct s - s to be re1 ted to the ir hihition of
cell divis ori.
B TAD1.LkF ____
rar th (a,c,f,j,k,m,n) PAFACAA
car *t . . eed (a,c,f,j,m,n) PAL BBA
C i1rEDfl 1 tsquarters (a,c,f,j ,k,rn,n,o) PBD kEBA
-(1-i thylpro ’1 )—3 , 4-dUiethyl-2 , 6-dini trobenzenamine
Pr 1 13
Issued: 01—31—83 1—108501—i
-------
EPA Index to Pesticide Chemicals
PENDflIE’IHALIN
B1 DADLE F WEEES CONrr )LLED : (continued)
ca on pursiane (a,c,f,j,k,m,n) PEDA 8A
Florida pusley (a, c , f, j,m ,n) P A B
kochia (c,f,j,k,n) PBDAIBA
ladysthurth (1) PEAA P
Pennsylvania smartweed (a,d,l,o) PEAA O
redroot pigweed (0) PA CB I
spurge (annuals) (c,f,j,xn,n) PB1Th 1 G A
velvetleaf (a,d,l,o) P ABB2
venice llow (0)
GRASSES ANt) an Ea 1cec Is ca I r,r, rY
barnyardgrass (a ,c,f,j,k,m,n,o) PCABHBB
broadleaf sigrtalgrass (a,c,f,j,m,n) PCMRBD
crabgrass (a, c, f, j ,k ,m , n ,o) P BFAA
cr footgrass (c,f,m) PcABcBA
fall panicum (a,c,f,j,k,m,n,o) ACEBD
field sandbur (j) PCAA .JBB
giant foxtail (a,c,f,j,k,m,n,o) PO CUBA
osegrass (a,c,f,j,k,m,n) BIBA
green foxtail (a,c,f,j,k,m,n,o) PCACUBF
itchgrass (j)
johnsongrass (e) PCAQ*iBC
johnsongrass (seedling) (a,c,f,j,m,n) P BG
panicum (p) P( CEAA
proso millet (b,j) PC CEBI
rice (h) C A
shattercane (g,j) AC4BB
Texas panicum (a, c , f, j,m ,n)
witchgrass (a,f,j ,m,n) P CEBC
woolly cupgrass (a) PCABLBR
yell foxtail (a,c,f,j,k,m,n,o) PCACUBD
Pt NP R UtMtR CLAIMS :
tobacco sucker control PZZZZZA
(a) control in field corn with pree rgence rates of 0.75—2.0 lb a.i./A
(b) reduced cat etition in field corn with preemergence rates of 0.75—2.0
lb a.i./P
(c) control in cotton with preplant incorporated rates of 0.5—1 • 5 lb
a.j./A; and in peanuts with preplant incorporated rates of 0.5—1.0
lb a.i./A
14
Issued: 01—31—83 I1085012
-------
EPA Index to Pesticide Chemicals
P DIMETHALIN
Footnotes (continued)
(d) reduced caripetition in cotton, peanuts, soybeans and sunflowers with
preplant incorporated rates of 0.5—1.5 lb a.i./? ; arid in field corn
and grain sorght.mt with posten rgence incorporated rates of 0.5—1.5
lb a. i . /A; and in transplanted tobacco with preplant incorporated
rates of 0.75—1.5 lb a.i./A
(e) suppression only in cotton and soybeans with preplant incorporated
rates of 1—2 lb a.i./A
(f) control in soybeans with preplant incorporated rates of 0.5—1.5
lb a.i./A
(g) control in soybeans with preplant incorported rates of 1.0—1.5
lb a.i./A
(h) control in soybeans with preplarit incorporated rates of 1—2 lb
a. i . /A
(i) suppression only in soybeans with preplant incorporated rates of
1—2 lb a.i./A
(j) control in field corn and grain sorghun with posten rgence
incorporated rates of 0.5—1.5 lb a.i./A
(k) control in potatoes with preenergence or preexiergence incorporated
rates of 0.75—1.5 lb a.i./A
(1) reduced cc*npetition in potatoes with preen rgence or preenergence
incorporated rates of 0.75-1.5 lb a.i./A
(m) control in transplanted tobacco with preplant incorporated rates
of 0.75—1.5 lb a.i./A
(n) control in sunflowers with preplant incorporated rates of 0.5—1.5
lb a.i./A
(0) control in field corn with preenergence rates of 1.5—2.0 lb a.i./
(p) control in cotton with preplant incorporated rates of 0.56—1.5
lb a.i./A
15
Issued: 01—31—83 11058013
-------
EPA Index to Pesticide Chemicals
PENDIME’fl ALIN
Site, Ibsage
and Formulation ‘ Iblerance, Use, Limitations
(lb a.i./A)
AGRICULTURAL C1 CPS
Corn, field 0.1 ppn (fodder, forage, grain) 28006 AA
Winter wheat and winter barley may be planted in
the fall 90 days after a postemergence incorpor-
ated application in an irrigated crop. The treated
crop must be gr n to maturity and harvested before
planting wheat or barley.
General Information : With the exception of minini.un
tifl.age systems, the seed bed should. be firm and
free of clods and trash • Use only where adequate
tillage is practiced to provide good seed coverage.
Plant seed at least 1.5 inches deep. Adequate
rainfall or overhead irrigation is necessary within
7 days after application for optimum control. If
cultivation is necessary because of soil crusting,
soil cat action, or weed germination before rain or
irrigation, use shallcM tillage, being certain that
the corn seeds are bel the tilled area. Wait
7—10 days before cultivating after early poste r-
gence treatu nts. Use the higher rates for fine
soils, or those with higher organic matter content,
or if heavy weed populations are anticipated, or
if extensive crop residues were present prior to
seedbed preparation. lb not use on muck or peat
soils. If crop loss occurs, corn, cotton or
soybeans can be replanted the sane year without
adverse effects. If corn is replanted, seeding
depth must be bel the retilled area. lb not
apply ncre than once per crop season.
0 • 75—2 • 0 Preenergence. Broadcast or band. Apply after
(4 lb/gal EC) planting, but before weeds and crop energe in 10
or ncre gallons of water or in 20 or nore gallons
of liquid fertilizer per acre by ground egui uent.
Make aerial applications in 5 or nore gallons of
water per acre.
1.5—2.0 Preeinergence. Broadcast or band. Apply at or
(10% G) after planting, but before weeds and crop energe.
(3 lb/gal EC) Apply the EC in 10 or nore gallons of water per
acre. lb not use on sands or loamy sands. lb
not use on soils with less than 1.5% organic
matter content.
16
Issued: 01—31—83 1—105801—4
-------
EPA Index to Pesticide Chemicals
PENDfl’1E’I ALIN
Site, Dosage
and Formulation Iblerance, Use, Limitations
(lb a.i./A) —
AGRICULIURAL CPIDPS
Corn, field (continued)
1 • 0—1 • 5 Preemergence. Broadcast or band. riot apply
(3 lb/gal EC) the 3 lb/gal EC on sands or loamy sands, or on
soils that contain less than 1.5% organic matter.
0.75—1.5 Tank mix with atrazine; or cyanazine.
(4 lb/gal EC)
1.5 Use limited to IL, IN, IA, KS, MI, MN, MC, NE, NY,
(4 lb/gal EC) 1D, OH, PA, SD and WI. Preen rgerice. Broadcast
or band. Apply only on level planted corn.
not use on sands, loamy sands, sandy loazns, peat or
or muck soils. D not use on n diurn textured soils
containing less than 3% organic matter.
Tank nix with dicanta, din thylamine or sodium
salts.
1.0—1.5 Early posten rgence. Broadcast or band. Apply
(4 lb/gal EC) in 10 or i re gallons of water by ground equip! n
or in 5 or nore gallons of water by air. fl, not
apply in liquid fertilizer or foll ’iing pre rgent
pendinethalin applications. Apply no later than the
corn 2-leaf stage of growth, and when weeds are no
nore than 1 inch tall.
Tank mix with atrazine; or WP cyanazine formulations.
0 • 5—1.5 stemergence incorporated. The field must be
(4 lb/gal EC) cultivated and all energed weeds must be destroyed
prior to application. This should be done with a
sweep—type or rolling cultivator operated at
sufficient speed to throw at least one inch of soil
over the bases of the corn plants. Apply uniformly
to the soil surface in 10 or xtore gallons of water
per acre by ground equip ent; use drop nozzles, if
r cessary. Apply fran the 4-inch growth stage to
as late as the last cultivation (layby) and
incorporate thoroughly as soon as possible, but
within 7 days after application. If adequate nois—
ture is not received within 7 days after applica-
tion, incorporate with a sweep—type or rolling cul-
tivator. If cultivation is needed after application
and incorporation, the depth of the cut should not
17
Issued: 01—31—83 1—108501—5
-------
EPA Index to Pesticide Chemicals
PENDINE’IHALIN
Site, 1 sage
and Formulation t lblerance, Use, Limitations
(lb a.i./A)
AGRICULThRAL C Ps
Corn, field (continued)
exceed that used for incorporation. Livestock can
graze or be fed forage from treated fields 21 days
after applications.
May be tank mixed with atrazilne.
Cotton 0.1 ppn (cottonseed) 28007AA
1)) not feed forage or graze livestock in treated
cotton fields.
General Information : not plant winter wheat or
winter barley as fo11 i crops if higher rates were
used for rhiza johnsongrass control. Where
incorporation is required, do so within 7 days
after application prior to planting. For flat-
planted cotton, mechanical incorporation should be
into the top 1—2 inches of soil. When application
is to be made over the beds of bedded cotton,
mechanical incorporation should be into the top
1—2 inches of soil. When applying to flat land
prior to bedding, mechanical incorporation should
be of sufficient depth so that bedding does not
bring up untreated soil. After application, rotary
hoeing, shall cultivation or hand hoeing can be
practiced without reducing weed control. Use the
higher rates’ for fine soils, or if heavy weed
populations are anticipated, or if application is
made fran 60—140 days before planting, or if
extensive crop residues were present prior to
seedbed preparation. Use the 1.5 lb a.i./A rate
on heavy, clay soils. If loss of cotton crop
occurs, any crop registered for preplant incor-
porated use can be replanted the same year into
treated soil without adverse effects. If
replanting is necessary, do not re rk the soil
deeper than the originally treated zone.
18
Issued: 01—31—83 1—108501—6
-------
EPA Index to Pesticide Chemicals
PENDIME’mALIN
Site, I sage
and Fbrmulatiori ‘ Iblerance, Use, Limitations
(lb a.i./A)
AGRICULTURAL C1 )PS
Cotton (continued)
0.5—1,5 Preplant incorporated. Broadcast or band, Apply
(4 lb/gal EC) unifonnly in 10 or nrre gallons of water or in
20 or n re gallons of liquid ferti1izer per acre
0.56—1.5 by ground equip ent. Apply in S or nore gallons
(3 lb/gal EC) of water per acre by aircraft. Apply iim diately
before planting or up to 60 days prior to planting
in all states except AZ, CA, LA, NM, MI, OK and
TX where it may• be applied in the fall, after
October 15th (up to 140 days prior to planting
cotton).
May be followed by an overlay preemergence
application of diuron; or flucineturon.
1.0—2.0 Preplant incorporated. Broadcast or band • For
(4 lb/gal EC) control of rhizalE johnsongrass, use a chisel
plow or similar in lement to bring the rhizat s to
the surface. ( iop rhizanes into nall pieces with a
disk harrow set to cut 4-6 inches deep and operate in
t different directions at 4—6 mph. Apply
uniformly in 10 or nore gallons of water or in
20 or nore gallons of liquid fertilizer per
acre by ground equi ient. Apply in 5 or fore
gallons of water per acre by aircraft. Apply
ittit diate1y before planting or up to 60 days prior
to planting. Incorporate as soon as possible
and within 7 days after application. Deep and
thorough incorporation is necessary. I iZQTe
johnsongrass will be suppressed after the first
year and controlled after the same treatment the
following year. 1 not use in AZ, CA and NM.
D riot use on soils with nore than 3% organic
netter content.
0.5—1.5 UselimitedtoAz,CA,M’landtheUpperandlower
(4 lb/gal EC) El Paso Valley of TX.
Preplant incorporated. Broadcast or band. Apply
uniformly in 10 or itore gallons of water per
acre by ground equip nt. May be applied prior
to listing or over partially finished or finished
beds. Incorporate iuinediately after application.
Maintain good agitation at all times. Use
mechanical agitation in AZ arid CA.
Tank mix with pranetryn.
19
Issued: 01—31—83 11085017
-------
EPA Index to Pesticide Chemicals
PENDIMFIHALIN
Site, Dosage
and Formulation Tolerance, Use, Limitations
(lb a.i./A)
A ICTJU JPAL C1 JPS
Cotton (continued)
0.5—1.5 Preeit rgence. Broadcast or band. Apply uniformly
(4 lb/gal EC) in 10 or nx re gallons of water or in 20 or n re
gallons of riitrcgen solution per acre by ground
equi ent immediately after planting. Make sure
cotton seeds are planted 1 inch or deeper.
not use in AZ, CA, 4, OK or TX.
Tank mix with fluat turon; or riorfiurazon (apply
norfiurazon tank mix in water only).
Peanuts 0.1 p n (peanuts, hay, forage) 028015AA
0.25 ppn (peanut hulls)
General Information : Where incorporation is
required, do so within 7 days after application prior
to planting. For flat-planted peanuts, mechanical
incorporation should be into the top 1—2 inches of
soil. When application is to be made over beds of
bedded peanuts, mechanical incorporation should be
into the top 1-2 inches • When applying to flat
land prior to bedding, mechanical incorporation
should be of sufficient depth so that bedding does
not bring up untreated soil. After application,
shallow cultivation or hand hoeing can be practiced
without reducing weed control. Use the high rate
for each region if heavy weed populations are
anticipated or if extensive crop residues were
present prior to seedbed preparation. If loss of
peanut crop occurs, peanuts or any crop registered
for preplant incorporated use can be replanted the
same year. If replanting is necessary do not
re rk the soil deeper than the originally treated
zone.
Preplant incorporated. Broadcast or band. Apply
uniformly in 10 or uore gallons of water or in
20 or t ore gallons of liquid fertilizer per acre
I ground equip ent. Apply in 5 or nore gallons
of water per acre by aircraft. Apply iimediately
before planting or up to 60 days prior to planting.
May be tank mixed with vernam.
0.5—0.75 sage for I4, OK and D(.
(4 lb/gal EC)
o • 75—1.0 Dosage for other peanut-growing states.
(4 lb/gal EC) 20
Issued: 01—31—83 110850l8
-------
EPA Index to Pesticide Chemicals
PEMDIMETHALJIN
Site, sage
and Formulation ‘ Iblerance, Use, Limitations
(lb a.i./A)
AGRICLTL’I PAL C PS
Potatoes 0.1 ppn (potato) 01401 3A
General Information : Where incorporation is
required, do so within 7 days after application
prior to planting. Incorporation is not necessary
if adequate rainfall or irrigation is received
within 7 days after application. Where drag-off
is practiced, apply and incorporate before, at, or
after drag-off but before potatoes and weeds emerge.
When applying as a preemergent incorporated treat-
mant, incorporation should be uniform and into the
txp 1-2 inches of soil. May be applied
preemergence through sprinkler irrigation systems
in all states except CA. Use the higher rates for
fine soils with ri re than 3% organic matter, or when
heavy infestations of grass or broadleaf weeds are
anticipated or if extensive crop residues were
present prior to seedbed preparation. 1 not use
on peat or n ick soils. Previous crop residues
should be thoroughly mixed to a depth of 4-6 inches
by pl ing or discing before planting potatoes.
0, 75—1.5 Pree rgence. Broadcast or band. Apply after
(4 • 0 lb/gal EC) planting, but before potatoes and weeds emarge or
after drag-off in 10 or ixore gallons of water or
in 20 or rrcre gallons of liquid fertilizer per acre
by ground equi nt. Make aerial applications in
5 or n re gallons of water per acre. Use higher
rates on fine textured soils with greater than 3%
organic matter. May be applied through sprinkler
irrigation systei in all states but CA. 1)D
not apply when wind velocity is greater than 10
nçh. qitation nust be maintained in the
nurse tanks. Apply in 0.5—0.75 inches of
irrigation water.
0.75-1.5 Pre rgence incorporated. Broadcast or band.
(4.0 lb/gal EC) Apply and incorporate after planting or before,
at, or after drag-off, but before potatoes and
weeds en rge in 10 or ncre gallons of water or in
20-or nore gallons of liquid fertilizer per acre
by ground equipment. Make aerial applications
in 5 or nore gallons of water per acre. Use
higher rates on fine textured soils with itore than
3% organic matter. May be applied through sprinkler
irrigation syst in all states but CA. Aaitation
Trust be maintained in the nurse tanks.
Issued: 01—31—83 1—108501—9 2 1
-------
EPA Index to Pesticide Chemicals
PENDIME’THALrN
Site, I)sage
and Formulation ‘ Iblerance, Use, Limitations
TIB a.i./A)
AGRICUL’I JRAL CI DPS
tatces (continued)
0.5—1.5 Preemergence. Broadcast or band. Apply after
(4 lb/gal EC) planting, but before potatoes and weeds emerge
or after drag-off in 10 or n re gallons of
water or 20 or nore gallons of liquid fertilizer
per acre by ground equipment. Make aerial
applications in 5 or rt re gallons of water
per acre. Use higher rates on fine textured
soils with greater than 3% organic matter.
Tank mix with metribuzin.
0 • 5—1.75 Preemergence incorporated. Broadcast or band.
(4 lb/gal BC) Apply and incorporate after planting, or before,
at, or after drag-off, but before potatoes and weeds
e rge in 10 or nore gallons of water or’ in 20
or nore gallons of liquid fertilizer per acre
by ground equipment. Make aerial applications in
5 or itore gallons of water per acre. Use higher
rates on fine textured soils with greater than
3% organic matter.
Tank mix with eptam.
Rice 0.05 ppm (rice grain) 024004AA
j , not bale or use rice straw fran treated fields
for feed or bedding.
General Information : E not use trea nent in water-
seeded rice. lb not apply if there is a chance of
rain within 6—8 hours. ? equate rainfall or irri-
gation (flush) should be received within 7 days
after application. b flood water should be on
fields at tiit of application. Use high rates for
medium and fine textured soils if heavy weed
populations are present. lb not apply tank mixture
within 14 days before or after insecticide treat-
ments, do not make itore than one application per
season or apply in liquid fertilizer. Previous
crop residues should be thoroughly mixed into
the soil to a depth of 4—6 inches by pl iing or
disking before planting rice. Apply when barnyard—
grass is in the 1-3 leaf gr th stage with
an occassional 4 leaf plant or when sprangletop
is less than 0.5 inches.
22
Issued: 01—31—83 1—108501—lU
-------
EPA Index to Pesticide Chemicals
PENDIME1 ALIN
Site, flsage
and Formulation ¶Lblerance, use, Limitations
(lb a.i./A)
AGRICULTURAL C CPS
Rice (continued)
0.75—1.0 Early postemergence. Use on dry—seeded rice.
(4 lb al/gal EC) D not use in CA. Apply according o stage of
growth of barnyardgrass and/or sprangletop.
Apply after rice emergence by ground equi nent
in 15—25 gallons of water per acre, or aerially
in 10—12 gallon of water per acre for adequate
coverage. Minimize drift; do not spray aerially
if wind velocity is greater than 5 mph or by
ground If wind velocity is greater than 10 mph.
Tank mix with propanil.
Sorght.nn , grain 0.1 pn (fodder, forage, grain) 28019AA
Winter wheat and winter barley may be planted
in the fall 90 days after a postemergence in-
corporated application in an irrigated crop or 120
days after an application in the dry land crop.
The treated crop must be grown to maturity and
harvested before planting to wheat or barley.
Livestock can graze or be fed forage fran treated
crop 21 days after application.
General Information : Trea ients must be thoroughly
and uniformly incorporated into the top 1 inch
of soil, or receive adequate irrigation water or
rainfall within 7 days after application. Mechanical
incorporation provides best results under situations
of low rainfall or soil goisture when deep germinat-
ing weeds such as shattercane or field sandbur are
anticipated. Treathents can be applied fran the
4 inch growth stage to as late as the last cultiva-
tion (layby) of sorghum. Jhen cultivation is
needed after application and incorporation,
the depth of cut should be no deeper than the depth
of cut used to incorporate. D ot use on peat or
muck soils. Use higher rates when heavy weed in-
festation are anticipated or on fine textured
soils. D not apply x ore than once a crop season.
23
Issued: ol—31—83 1—108501— Il
-------
EPA Index to Pesticide Chemicals
PENDIMEThALIN
Site, T) sage
and Formulation ‘ Iblerance, Use, Limitations
(lb a.i./A)
AGRICULTUPAL PS
Sorghum, grain
(continued)
0.5—1.5 ? stai ergence incorporated. The field must be
(4 lb/gal EC) cultivated and all emerged weeds destroyed prior to
application. This should be done with a sweep—type
or rolling cultivator operated at sufficient speed
to thr at least one inch of soil over the
bases of the grain sorghum plants. Apply
uniformly in 10 or ttcre gallons of water per
acre by ground equipi nt; use drop nozzles,
if necessary.
Soybeans 0.1 ppn (Soybeans, forage and hay) 28023AA
General Information : not plant winter wheat
or winter barley as fOl1 rJ crops if higher rates
were used for rhizai johnsongrass or itchgrass
suppress ian, or for red rice control. Where
incorporation is required, do so within 7 days after
application prior to planting. For flat-planted
soybeans, n chanica1 incorporation should be into
the top 1—2 inches of soil. When applying to flat
land prior to bedding, n chanical incorporation
should be of sufficient depth so that bedding
does not bring up untreated soil. Use the higher
rates on fine soils, and if heavy weed populations
are anticipated, or if extensive crop residues were
present prior to seedbed preparation. Use the 1.5
lb a.i./A rate on heavy, clay soils. If cLOp loss
occurs, any crop registered for preplant incorpor-
ated use can be replanted. If replanting is neces-
sary, do not rework the soil deeper than the
originally treated zone. D not use in .
0.5-i. 5 Preplant incorporated. Broadcast or band.
(4 lb/gal EC) Apply uniformly in 10 or nore gallons of water or in
20 or nore gallons of liquid fertilizer per acre
by ground equi nent. Apply in 5 or nore gallons
of water per acre by aircraft. Apply ininediately
prior to planting or up to 60 days prior to plant-
ing. In the Southern States including the Eastern
Coastal Plain there are no organic matter restric-
tions • For the Northern States, use the higher
rates when organic matter is greater than 3%.
Livestock can graze or be fed soybean forage fran
treated fie1d . 24
Issued: 01—31—83 1—108501—12
-------
EPA Index to Pesticide Chemicals
PEDIME ALIN
Site, Dosage
arid Ebrinulation ‘ Iblerance, Use, Limitations
(lb a.i./A)
AGRICt3L JRAL PS
Soybeans (continued)
0.5—1.25 Preplant incorporated. Broadcast or band. Apply
(4 lb/gal EC) uniforxr’ly in 10 or n re gallons of water p r
acre by ground equip ent, or in 5 or nore gallons
of water by aircraft.
Tank mix with netribuzin; or follow with a
preei rgence application of metribuzin; or
linuron.
0.75—1.25 Use limited to the ? orthern States.
(4 lb/gal EC) Preplant incorporated. Broadcast or band. Apply
uniformly in 10 or ircre gallons of water per
acre by ground equipi nt, or in 5 or nore gallons
of water by aircraft.
Tank mix with chloramben; or chloraniben and
metribuzin; or follow with a preemergence applica-
tion of chioranten.
1.0-1.5 Preplant incorporated. Broadcast or band. For the
(4 lb/gal EC) control of shattercane, apply arid incorporate into
the top 2 inches of soil. Cultivation may be
required to control weed escapes and late germinat-
ing shattercane. May be followed with a preeT rgenCe
application of metribuzin; or chloramben; or
linuron.
May be tank mixed with metribuzin at the lower
pendimethalin dosage of 0.75—1.25 lb a.i./A.
1-2 Preplant incorporated. Broadcast or band. For the
(4 lb/gal EC) control of red rice and suppression of itchgrass.
1-2 Preplant incorporated. Broadcast or band. For
(4 lb/gal Ec) control of rhiza johnsongrass, use a chisel plow
or similar iiipl nt to bring the rhizat s to
the surface. Chop rhizcines into 11 pieces with
a disk harrow set•to cut 4-6 inches deep andoperate
in t different directions at 4—6 mph. Apply
uniformly in 10 or n re gallons of water or in
20 or ncre gallons of liquid fertilizer per acre
by ground equipment. Apply in 5 or ilore gallons
of water per acre by aircraft. Apply Inmediately
before planting or up to 60 days prior to planting.
25
Issued: 01—31—83 1—10850113
-------
EPA I ndex to Pesticide Chemicals
PENDIME T mALIN
Site, I sage
and Formulation Tolerance, Use, Limitations
(lb a.i./A)
AGRICULTUPAL CI )PS
Scyans (continued)
Incorporate as soon as possible and within 7 days
after application. t ep and thorough incorporation
is necessaty. Phizcme johnsongrass will be suppres-
sed after the first year and controlled after the
sane treatit nt the following year. D not use in
AZ, CA and or on soils with gore than 3% organic
matter.
0.5—1.25 Preeu rgence. Broadcast or band. Apply
(4 lb/gal EC) uniformly in 10 or n re gallons of water per
acre by ground equip nent; or in 5 or rtore
gallons of water by aircraft.
Tank mix with n tribuzin; or linuron.
0.75—1.25 Use limited to the tbrthern States
(4 lb/gal EC) Preetergence. Broadcast or band. Apply
uniformly in 10 or nxre gallons of water per
acre by ground equi *IEnt, or in 5 or nxre gallons
of water by aircraft.
Tank mix with chiorainben; or chlorasnben and
metribuzin.
0.5—1025 Pre nergence. Broadcast. For use in minimum and
(4 lb/gal EC) no—till soybeans. Apply uniformly in 20—60 gallons
of water per acre with ground equi nt. Apply at
planting or up to 2 days after planting. Adequate
rainfall imist be received within 7 days after
trea nt. 1) not use on peat or ni.ick soils.
Tank mix with n tribuzin and paraquat dichioride;
or linuron and paraquat dichioride. 1 lete
paraquat dichloride fran the tank mixes if vegeta-
tion is absent at the tiime of application.
Sunflower 0.1 ppn (sunflower seeds) 28021AA
i not feed forage or graze livestock in treated
sunfl r beds.
General Information : Where incorporation is re-
quired, do so within 7 days after application
prior to planting. For flat planted sunflowers,
i chanical incorporation should be into the top
1—2 inches of soil. When application is to be made
26
Issued: 01—31—83 1—108501—14
-------
EPA Index to Pesticide Chemicals
PENDIME ALIN
Site, sag
and Formulation ‘ Iblerance, Use, Limitations
(lb a.i./A)
A ICUL’I JRAL C )PS
Sunflower (continued)
over beds of bedded sunflowers, mechanical incor
poration should be into the top 1—2 inches of soil.
When applying to flat land prior to bedding,
mechanical incorporation should be of sufficient
depth so that bedding does not bring up untreated
soil. After application, rotary hoeing, shallow
cultivation, or hand hoeing can be practiced without
reducing weed control. Use the higher rates for
fine soils or if heavy weed populations are anti-
cipated, or if extensive crop residues were present
prior to seedbed preparation. Use the 1.5 Lb a.i./A
rate on heavy, clay soils. riot use on peat or
imick soils. If loss of sunflower crop occurs, any
crop registered for preplant incorporated use can
be replanted. If replanting is necessary do not
re rk the soil deeper than the originally treated
zone.
0.5—1 • 5 Preplant incorporated. Broadcast or band. Apply
(4 lb/gal EC) uniformly in 10 or iore gallons of water or in 20
or tiore gallons of liquid fertilizer per acre by
ground equi nent. Apply in 5 or nore gallons of
water per acre by aircraft.
For Southern States there are no organic matter
restrictions. For t brthern States, use higher
rates on soils with niore than 3% organic matter.
0.75—1.25 Use limited to brthern States.
(4 lb/gal BC) Preplant incorporated. Broadcast or band. Apply
uniformly in 10 or nore gallons of water per
acre by ground equipnent. Apply in 5 or nore
gallons of water per acre by aircraft. t not
use on coarse soils. Use higher rates on fine
soils with niore than 3% organic matter. Use
higher rates for each soil texture if velvetleaf
and nartweed infestations are anticipated.
Tank mix with, or follow with a preen rgence
application of chioranten.
27
Issued: 01—31—83 1—108501—15
-------
EPA Index to Pesticide Chemicals
P DIME’fl1ALIN
Site, sage
and Formulation Tolerance, Use, Limitations
(lb a.i./A)
Tobacco N.F. 26003M
General Information : For weed control in
transplanted tobacco. Lb not apply as a post
transplant spray. Where incorporation is required,
do so within 7 days after application, prior
to planting. May be applied imediately before
transplanting or up to 60 days prior to trans-
planting tobacco. Thoroughly mix the previous
crop residues into the soil to a depth of 4—6
inches, prior to application. When applying to
flat land prior to bedding, mechanical incorpor-
ation should be of sufficient depth so that bedding
does riot bring up untreated soil. When applying
to flat land that will not be bedded, mechanical
incorporation should be into the top 1—2 inches
of soil. hiring transplanting, or if beds must
be reshaped prior to transplanting, avoid ti.Uage
that will bring untreated soil to the surface
or expose untreated soil on the bed or in the
furrow. After application, shallow cultivation
or hand hoeing can be practiced without reducing
weed control. Use the higher rates for fine
textured soils, or where heavy weed infestations
are anticipated, or if extensive crop residues were
present prior tO seedbed preparation. fl not
use on peat or muck soils. If loss of tobacco
crop occurs, any crop registered for preplarit in-
corporated use can be replanted. If replanting is
necessary, do not res* rk the soil deeper than
the originally treated zone.
0 • 75—1.5 Preplant incorporated. Broadcast or band. Apply
(4 lb/gal ) uniformly in 10 or nore gallons of water per acre
by ground equipuent. In FL, G , MD, NC, SC and
VA do not exceed 1.25 lb a.i./A. Use the higher
rates on fine textured soils.
28
Xuued: 01—31—83 1—108501—16
-------
A Index to Pesticide Cnemicals
P DIME I AI 3 IN
Site, t sage
and Formulation Tblerartce, Use, t jjni tat ions
(lb a.i./A)
1.49 Sucker control in flue-cured tobacco. Make two
(2.98 lb/gal EC) applications to tobacco that is uniform in height,
or to non—uniform tobacco that is to be topped
low enough so that the remaining upper leaves are
fully e cpanded Make the first application at
early first flowering, just after topping. Make
the second application before axillary buds exceed
one half inch in length. Apply in 50. gallons
of water per acre with boo n type power sprayers,
or in 1 gallon of water per 130—160 plants with
hand operated sprayers (with proportionately less
active ingredient).
Formulated with xylerie.
1.49 Sucker control in flue—cured tobacco. Use on
(2.98 Lb/gal EC) irregularly flowering tobacco or tobacco that
is to be topped at full, height in the button
stage or earlier. Make a single application
of fatty alcohols (0.5% C6, 42% C8, 56% ClO,
1.5% C12) at topping time. Follow with an
application of pendimethalin before axillary
buds exceed one half inch in length. Apply in
50 gallons of water per acre with bocin type
power sprayers, or in 1 gallon of water per
130—160 plants with hand operated sprayers
(with proportionately less active ingredient).
Fornulated with xylene.
1.86 Sucker control in burley tobacco. ‘Ibp when
(2.98 lb/gal EC) the majority of plants are in the early flower-
ing stage. ‘Ibp low enough so that the remaining
upper leaves are fully expanded. Apply ii nediately
after topping. Make only one application per year.
Apply in 50 gallons of water per acre with boan
type power sprayers, or in 1 gallon of water per
130—160 plants with hand operated sprayers (with
proportionately less active ingredient).
Fornulated with xylene.
29
Issued: 01—31—83 I—108501 l7
-------
EPA Index to Pesticide Chemicals
P Dn€’mAr. IN
Site, I sage
and Formulation Lblerance, Use, Limitations
QR TAtS
Abelia 34016AA
Arborvitae 3502.] .AA
Botttebrush 34262AA
Boxwood 3403 1AA
Cau flia 3403GM
Chamaecyparis 35038AA
Cotoneaster 34045AA
q w ood 35043AA
onymus 34053AA
Firethorn 34058AA
Forsythia 34062AA
Gardenia 34063AA
Bofly 3407QAA
Hydrangea 3407 3M
Juniperus 35073AA
Ligustrun 34 088M
35093AA
I ander 34 102M
Pieris 34fl1AA
Pine 35098AA
Pittos orun 341.1 3M
Fotentifla 34.11 SM
dodendron 341.]. 8M
Spirea 3413QAA
Viburxun 34 137AA
Xylosaia 34 084AA
Yew 35 13QAA
1 ed control in container (potted liners, bare
(1% G) root liners, individual containers) and field
gr n woody ornan ntals. Loosen the soil to
re ve existing weeds prior to application.
Apply evenly and water in inuediately after
application. For season long weed control,
reapply at 3 munth intervals. D , not incorporate
or use in greenhouses.
For milated with oxyfluorfen.
30
Issued: 01—31—83 1—108501—18
-------
EPA Index to Pesticide Ch icals
PE DIr4 1’HALIN
Site, D sag
and Fonmllation ‘ Iblerance, Use, Limitations
AERIAL AND TANK MIX APPLICATICtS
Aerial A lication 9001500
Refer to
AGRICUL’IVRAL ( DPS
Corn, field, Cotton, Peanuts, Potatoes, Rice,
Soybeans, Sunfl ers
Tank Mix
Refer to
A ICUL JRAL C PS
Corn, field, Cotton, Peanuts, Potatoes, Rice,
Sorghun, grain, Soybeans, Sunfl rs
31
Issued: 01—31—83 140850149
-------
PA Index to Pesticide Chemicals
P DIMETHALIN
Listing of Registered Pesticide Products by rnu1ation
90% technical chemical
pendin tha1in (108501)
000241—00245
1% granular
pendimethalin (108501) plus oxyfl xrf en (111601)
000538—00172
10% granular
perxlinEthalin (108501)
000241—00254
2.98 lb/gal emulsifiable concentrate
pendimethalin (108501) plus xylene (086802)
000241—00247
3 lb/gal emulsifiable centrate
pendin tha.1in (108501)
000241—00244
4 lb/gal emilsif fable concentrate
pendlinethalin (108501)
000241—00243
32
Issued: 01—31—83 1—108501—20
-------
EPA Index to Pesticide Chenicals
pE DD ALIN
A çendix A
Listing of C m n Qienical Names t ed in the Entry
thenical ( lenical Name EPA Acceptable
Code (source) C 1 . on/Q nica1 Name
028201 pr ani1 3’, 4’ -didilor ropiOflaflilide
041401 eptam S—ethyl dipcoWlthiocarbamate
041404 vernam S-pr yl dipropyithiocarbamate
100101 cyanazine 2-( (4- th1oro-6— (ethylainino ) -5-
triaz in-2--yl. )axnino) -2-rnethylpr iOnitrile
101101 metribuzin 4— a mim—6-(l,l-diinethylethyl) 3
(methylthio)—1, 2,4—triazin—5(4H)-Ofle
33
Issued: 01—31—83 1—108501—21
-------
ii. REOUIREMFNT FOR SUBMISSION OF GENERIC DATA
A. This portion of the guidance document is a Notice
issued under the authority of FIFRA sec. 3(c)(2)(B). The
tables following this section list the data required for
maintaining the registrahility of each product.
EPA has determined that additional generic data described
in Table A must be submitted to EPA for evaluation in order
to maintain in effect the reqistration(s) of your product(s)
identified as an attachment to the cover letter accompanyinq
this guidance document. As required by FIFRA sec. 3(c)(2)(R),
you are required to take appropriate steos to comply with
this Notice.
EPA may suspend the registration of each of those products
unless, within the specified time, you have informed EPA how
you will satisfy the requirements of this Notice. Any such
suspension will remain in effect until you have complied with
the terms of this Notice.
B. What Generic Data’/ Must be Submitted . You may deter-
mine which generic data you must submit by consulting Table A
at the end of this chapter. That table lists the qeneric
data needed to evaluate the continued reqistrabilj.ty of all
products, and the dates by which the data must be submitted.
The required studies must be conducted in accordance with
EPA approved protocols (such as those contained in the Pesticide
Assessment Guidelines 2/ or data collected under the approved
protocols of the Organization for Economic Cooperation and
Development (OECD). If you do not wish to develop data
in support of certain uses appearing in your labeling, you
may delete those uses at the time you submit your revised
labeling.
For certain kinds of testing (generally ecological
effects), EPA requires the test substance to he a “typical
formulation,” and in those cases EPA needs data of that tvoe
1/ Generic data pertain to the ProPerties or effects of a
particular ingredient, and thus are relevant to an evaluation of
the risks of all products containina that ingredient, reaardless
of the product’s unique composition or specific use. Product-
specific data relate only to the properties or effects of a
product with a particular composition (or a group of products
with closely similar composition).
2/ The Pesticide Assessment Guidelines are available in hard
copy or microfiche from the National Technical Information
Service, 5285 Port Royal Road, Sprinqfield, Va. 221.61.
34
-------
for each malor formulation cate orv (e.q., emulsifiable concen-
trates, wettable powders, qranulars, etc.) These are classified
as generic data and when needed are specified in Table A.
EPA may possess data on certain “typical formul.ations” hut
not others. Note : “Typical formulation” data should not be
confused with product-specific data (Table B) which are
required on each formulation. product—specific data are
further explained in Charter III of this document.
C. Options Available for Complying With Requirements
to Submit Data
Within 90 days o your receipt of this Notice you must
submit to EPA a completed copy of the form entitled “FIFRA
Section 3(c)(2)(B) Summary Sheet” [ EPA Form A5RO—1, Appendix
11-3] for each of your products. On that form you must state
which of the following methods you will use to comply with
the requirements of this Notice:
1. (a) Notify EPA that you will submit the data, and
(b) either submit the existing data you believe will
satisfy the requirement, or state that you will qenerate
the data by conducting testinq. If the test procedures
you will use deviate from (or are not specified in) the
pesticide Assessment Guidelines or protocols contained in
the Reports of Expert Groups to the Chemicals Group,
Organization for Economic Cooperation and Development
(OECD) Chemicals Testing Proqramme, you must enclose the
protocols you will use.
OR
2. Notify EPA that you have entered into an aqreement
with one or more other registrants to iointly develop (or
share in the cost of develoninq) the data. If you elect
this option, you must notify EPA which registrant(s) are
parties to the agreement.
OR
3. File with EPA a completed “Certification of Attempt to
Enter Into an Agreement With Other Registrants for Develop-
ment of Data” (EPA Form 8580—6, Appendix II_4)*/
*1 FIFRA sec. 3(c)(2)(B) authorizes joint development of
data by two or more registrants, and provides a mechanism by
which parties can obtain an arbitrator’s decision if they agree
to jointly develop data but fail to agree on all the terms of
the agreement. The statute does not compel any registrant to
agree to develop data jointly.
(Footnote continued on next page)
35
-------
(.)P
4. Request that PA amend your registration by del.etina
the uses for which the data are needed. (This option is
not available to applicants for new products.)
OR
5. Request voluntary cancellation of the reaistration(s)
of your products for which the iata are needed. (This option
is not available to applicants for n w products.)
1). Procedures for Requesting Changes in Testing Methodoloqy
and F xtensions of Time
EPA recoqnizes that you may disagree with our conclusions
regarding the appropriate ways to develop the required data
or how quickly the data must be submitted. If the test
procedures you plan to use deviate from (or are not specified
in) the registration guidelines or rotoco1s contained in
the reports of the Expert Groups to the Chemical. Groups,
Organization for Economic Cooperation and Development (OECD)
Chemicals Testinq Proqramme, you must submit the protocol
for Agency review prior to the initiation of the test.
If you think that you will need more time to generate the
required data than is allowed by EPA’S schedule, you may
submit a request for an extension of time. The extension
request must be submitted in writina to the Product Manaqer.
(Footnote continued from previous page)
In EPA’s opinion, loint data development by a].l reais—
trants subiect to a data requirement or a cost-sharinq aareement
among all such registrants is clearly in the public interest.
Duplication of testinq could increase costs, tie up testing
facilities, and subiect an unnecessarily l.arge number of
animals to testing.
As noted earlier, EPA has discretion to suspend the
registration of a product when a reqistrarit fails to submit data
required under FIFRA Section 3(c)(2)(B). EPA has concluded that
it should encourage loint testinq rather than duplicative
testinq, and that suspension should be withheld in certain cases.
to further this goal. Accordingly, if (1) a reqistrant has
informed us of his intent to develoP and submit data required
by this Notice: and (2) a second reqistrant informs EPA that
it has made a horia fide offer to the first recistrant to share
in the expenses of the testing Ion terms to he aqreed upon
or determined by arbitration under FIFRA Section 3(c)(2)(R)(iii)h
and (3) the first registrant has declined to aqree to enter
into a cost—sharing agreement, EPA will not suspend the
second firm’s reqistratipn. 36
-------
Data Requir fleflt
§158.120 Product Chentist y
Product Identity :
61—1 — Identity of InqredientS
61—2 — Stat nent of Ccmposition
61-3 - Discussion of Formation of
Ingredients
Analysis arx3 Certification of Product
Inredients
62-1 - Preliminary Analysis
62—2 - Certification of Limits
62-3 - Analytical Methods for
E forc TEnt of Limits
Physical a ix ) th nica1 Characteristics
63—2 — Color
63-3 — Physical State
63-4 O5or
63—5 — Melting Point
63—6 — Boilinq Point
63-7 - Density, Bulk Density, or
Specific Gravity
ND
Yes 3/4/
Yes 3/5/
TABLE A
GENERIC DATA RE JIRE 1ENTS F(R PENDIME iALIN
lXes EPA Have Data
Tb Satisfy This
Requir nent? (Yes,
No or partially)
(90% 1 .I.)
Bib1iograp1 ic
Data Be Suliiütted
Under FIFRPk Section
CcvipositiOn
Citation
3(c)(2)(B)?
1X I
T( I
TG I
Yes
Partially
No
partially
No
Partially
00106751
00106751
00046347
00106751
Yes 2/6/
Yes 2 /7/
Yes 3/8/
No
TC?J
Yes
( 0187—00l
No
T(?d
Yes
GS0187—O01
T(? .I
Yes
( 0187—001
No
‘K .I
Yes
( 0l87—001
No
37
-------
Data Requirenient
S158.120 Product themistry
(continued)
— Solubility
— Vapor Pressure
— Dissociation constant
- Octano1/i ter partition
coefficient
63—12 —
63—13 — Stability
Other Requirements :
64— 1 — Sul uittal of sanpies
Partially
PAT Yes
PAl
PAl
TABLE A
( 2 ERIC TA REQ(JIRF IENrS FOR PEM)DIE’PIiALIN
1)Des EPA Have Data
To Satisfy This
1/ Requirement? (Yes,
Caiposition ? or Partially)
63— 8
63— 9
6 3—10
6 3—11
Bibi iograçJiic
Citation
?4 st 3ditiona1
Data Re Subuitted
t der FIFRA Section
3(c) (2)(B) ?
c 0l87-001 Yes /9/
(S0187—0O1
- Yes 2/
- Yes2/
- Yes2/
c ol87—0o1 Yes 2/10/
uIY I
‘I I Partially
thoice 11/
3
-------
11 (4) TABLE A
GENERIC E TA RE (JIREMENI S FOR PE DD1EThALIN
§158.120 Product themistry
(contirEed)
1/ CcztpositiOfl: T(?J = Technical grade of the active ingredient; PAl = Pure active ingredient; Choice = Choice o
several test subetances determined on a case—by—case basis.
2/ t th are reiuired and Trust be submitted no later than October 30, 1985.
3/ t ta are reiuired and Trust be submitted no later than April 30, 1986.
4/ The narte and address of the manufacturer or producer of each starting material used in the 90% technical
product is reiuired.
5/ A discussion of each iiipurity believed to be present at >0.1% based on the beginning materials, all ch ica1
reactions and any contamination is ra uired.
6/ Five or n re saTples nust be analyzed for the active ingredient (A.I.)/each inpurity present for which a certified
limit is rauired.
7/ A current Confidential Stat nt of Formula rrust be submitted.
8/ C jantitative mathocis to determine the remaining inpurities in the technical product are required.
9/ E ta are reiuired for solvents in P1 4 solubility at 20 C.
10/ The following data are rejuired for chemical stability: discussion of sensitivity of the A.I. to matal and matal ions,
stability of the A.I. at normal and elevated taiperatures, and the sensitivity of the A.I. to sunlight.
11/ This ccmpc*ind does not require the submittal of sanples.
39
-------
TABLE A
NERIC TA R (JIRF2€? ips F PE? IM PHAL N
Data Requir nents
1/
Canpos it ion
EXes EPA Have Data
Tb Satisfy This
I quir ent? (Yes,
No, or Partially)
Bibi iogra ic
Citation
NkiSt Alclltlonal
Data Be Sutmitted
Ur der FIFR Section
3(c)(2)(B)?
S158.125 Residue themistry
171—4 — Nature of 1 sidue (Metabolism)
171-4 - 1 sidue Analytical Method
—
Plants
PAIRA
Partially
00029803,
00031219,
00067293
00071121
Yes
3J7J8/
00039535,
00074621
00039537,
00093698
00046278,
00106779
00046280,
00106795
000c1963,
00108317
00051965,
00109915
00058478,
( 0l87—002
—
Livestock
PAlM and plant
metabolites
Partially
00067288,
00067289,
00046293
00046275
00071124
Yes
5/9/
—
Plant residues
TGkI and metabolites
40
Partially
00019004,
00023780,
00023781,
00023782,
00024823,
00025820,
00025821,
00025822,
00025827,
00025828,
00025831,
00025832,
00025833,
00025837,
00029018,
00029020,
00031212,
00031214, 00070962
00041898, 00071120
00041901, 00072810
00041904, 00072822
00039519, 00072823
00039520, 00072824
00039522, 00072825
00039526, 00106752
00039527, 00106791
00039528, 00106808
00051958, 00106830
00051959,
00051960,
00051961,
00051962,
00052558,
00058835,
Yes
2/10/
-------
TABLE A
RIC I TA R JIR}1’4EW1S FOR PEMDDIETUALIN
Data 1 quiL uents
— Animal residues
171—4 — Storage Stability Data
Ccvpoaition
T I and metabol ites
I es EPA Rave Data
‘1 Satisfy This
1 ciiir nent? (Yes,
No, or Partially )
Partially
Partially
Bibi jog ra ± ic
Citation
00023796, 00058835
00071129
!4ist h diticnal
Data Be Su initted
tJp 1er PIFRA Section
Yes / /
Yes
171-4 - M nit,x3e of the sidue-
i sidue St 1ies for Eadi
P cd Dae
Wot & Tuber veqetable j /
° Potatoes
Lag*zne Vegetables (Succulent
or Dried) Gros.
o
Partially
00025818, 00029801
00041897
Yes .4 /14/
Fbliage of Legulie
Vegetables C oi.ç
° Soybeans forage
and hay
Partially
00025818, 00029801
Yes .4/’ &/
00023786,
00023787,
00023788,
00023789,
00023790,
00023791,
00023792,
00023794
00023795
00023793
00029029
00030697
00093697
00106820
TSP Yea
00106797
Cereal aina ( o
Corn, grain
1 2/
Partially
41
Yes . 4 / 2/
-------
TABLE A
ERIC [ TA REQUrR ’1FMS FO PE?I)D* I’HALIN
I).es EPA Have Data J tist Mditional
lb Satisfy This Data Be Subnitted
1/ Ièquir nent? (Yes, Biblioqrap ic rXider FIFRA Section
Data Requir nents CcIT x)sition No, or Partially) Citation
Cereal (rains ( oup
o Rice grain Yes 00067283, 00071120
o Sorcdnin, grain TEP Yes 00106791, 00106807
00114313
Ftrage, Fodder, & Straw
of Cereal (kains (koup J
o Qrn, forage aid Partially 00023786, 00023794 Yes 4/19/
fodder 00023787, 00023795 ——
00023788, 00029028
00023789, 00029029
00023790, 00030697
00023791, 00093697
00023792, 00106820
00023793,
o Sorghiiu, forage PEP Partially 00106791, 00106807 Yes 4/20/
aid fodder 00114313 — —
Miscellaneous O vnodities
o O ttonseed TEP Partially 00018997, 00106829 Yes 4/21/
00106752,
o peanuts Partially 00031215, 00031217 Yes 4/22/
00031216, 00106785 ——
o Peanut forage PEP Yes 00106785, G90187—002 No
o Peanut hay Yes 00106785, ( 0l87—fl02
42
-------
TABLE A
NERIC I PA RB UIRF7IENFS FOR PEPlMMEn1 HALIN
Data Requir & ts
1/
Crxiix sit ion
))es EPA Have Data
‘t Satisfy This
R equir nent? (Yes,
No, or Partially)
Bibi ioqrarliic
Citation
?4ist Mditional
Data Be Sutxnitted
Under FIFRA Section
3(c) (2)(B)?
§158.125 Residue th nistry
171-4 - M nitu1e of the Residue-
Residue Sttxiies for Eath
FOod e
Miscellaneous Qzmncxiities
° Sunflower seeds
PEP
Partially
00134355
Yes 4/23/
— Fish
- Irrigated Crops
—— Field trials
-- P ed FOod/Feed
EP Partially
EP 28/
EP 28/
EP Reseived
00046293, 00071124 Yes 4/24/
43
-------
Data Ra uir nent __________________________________
§158.125 Residue Chemistry
(continued)
171—4 — Magnitude of the Residue—
Residue Studies for Each
Food Use
- Meat/mi 1k/poultry/eggs
o Cattle
o Milk
o Hogs
o Goats
O Poultry
o F gs
— Tobacco (non food) Partially 00129937 Yes 4/27/
16 (10)
GENERIC
DATA
RE JIREMENrs FOR PENDIMF iALIN
1/
Caiposition
Ekes EPA Have ta
To Satisfy This
Reguiresent? (Yes,
No or Partially)
Bibliographic
Citation
&ist Aiditional
Data Be Su itted
Under FIFRA. Section
3(c)(2)(B)?
TGAI
No
Yes
4/25/
1 A .I
No
Yes
4/9/
TGM
Yes
4/25/
TGAI
No
Yes
4/26/
‘I AI
Yes
4/26/
44
-------
TABLE A
17 (11) ( ERIC TPL RB )UIR 4FNrS FOR pf tl)IME’LW%LIN
l58.125 Residue themistry
(continued)
1/ QmçositiOfl: ‘JX I = Technical grade of the active ingredient; PAIRA = Pure active ingredient, radi9labelled; TEP =
Typical end-use product; EP = Fxid-use product.
2/ Data are required and must be sut:initted no later than April 30, 1987.
/ Data are required and must be sutinitted no later than October 30, 1986.
4/ Data are required and must be sut:initted no later than July 30, 1986.
5/ Data are required and must be suL znitted no later than April 30, 1986.
6/ Data are required and must be sukxnitted no later than October 30, 1985.
7/ k3ditional plant metaboli ii data are required to reveal the cx lete identity of radioactive extractable and non-
extractable residues encountered in plant tissue resulting frm treatment with radiolabeled pendiinethalin.
8/ Levels of metabolites remaining in polar fractions must be determined for possible toxicological residue concerns.
9/ Meta1x1i stuiies utilizing rtininants are required. Ani.mals must be dosed with ‘ 4 C ring lab& ed pendimethalin
for 3 days at a level > 1.5 pgn to identify residues. nima1s must be sacrificed within 24 hours of the
final dose. Distribution and characterization of residues must be determined in milk, muscle, fat, kidney, and
liver. If the riEdnant metabo1i n differs significantly frctn the rat data, then swine metabo1isi data will also be
required.
10/ If the additional metabolimn data show the presence of new metabolites, then additional methodology data may be
required.
11/ Additional data are required to show the stability of pendimethalin and its 3, 5-dinitrobenzl alcohol metabolite
in or on representative plant and animal s nples stored at freezinq temperatures for time intervals approximatinq
those of the treated sanpies used to determine the magnitule of the residue.
12/ A crop group tolerance is not appropriate at this time for the following reason: residue data are required for 3
additional representative menbers of this crop group (carrot, radish, suqar beet).
13/ A crop group tolerance is not a ropriate at this time for the following reason: data are required for t additional
methers of this group (beans and peas). Data for beans(dried, lima, snap) were reviewed and the tolerances were
issued for beans after this residue chemistry prolect s canpleted. Data for peas (dried and succulent) in support
of proposed tolerances for these ccim jditieS are currently under review.
14/ Depending on the results of the requested metabolism data, additional processing data (to be clarified)
may be required for soybeans.
15/ A crop group tolerance is not appropriate at this time for the following reason: additional data are required to
support the established tolerance for soybean hay, current data do not support the soybean forage tolerance.
Data for bean foliage and straw were reviewed and the tolerances were issued for beans after this residue chemistry
project s canpieted. Readue data for peas and pea vines in support of proposed tolerances for this ccmirdity
are currently under review.
45
-------
TARLE A
( NERIC E PA R1 XJuRF14 Nrs 1Y)R Pf MMME’rrw IN
S158 . 125 Residue themistty
(continued)
16/ Data are required for pendimethaljn and its metabolite in or on soybean hay and straw harvested 60 ç3ays after an
at—planting a licatjon made with ground or aerial equipnent of the 41h/ gallon milsifiahle concenkrate (EC) or
60% dispersable granular (DP) at 2 lb ai/acre. Tests must be conducted in Illinois, Minnesota and Missouri.
17/ Proposed tolerances for t representative members of this crop group (barley and wheat) are currently pending.
Data for sweet corn were reviewed and the tolerances were issued after this residue chemistry project for regis-
trat ion standard s ccii ,1eted.
18/ Proposed tolerances for three representative members of this crop group (barley, sweet corn and wheat) are currently
pending. Wien the currently pending tolerances are established, a crop group tolerance should be considered at that
time.
19/ If new metabolites are found, then additional field residue data for field corn may be required. Wien necessary,
data will be extrapolated fran the soybean processing study to corn.
20/ If new residue metabolites are found, additional metabo1i n and field residue data may be required for sorqhum.
21/ Additional processing data may be required for cottonseed. W ien necessary, data will be extrapolated frcm the
requested soybean processing study.
22/ Additional. metabo1j n data on peanuts may be required. Additional processing data may be required for peanuts. Wien
necessary, data will be extrapolated fran the soybean processing study.
23/ Additional processing data may be required for sunflower seeds. Wien necessary, data will be extrapolated frcxn the
requested soybean processing study.
24/ Residues of pendimethalin and its metaholite in edible tissues of catfish and crayfish obtained fran certain
cultural conditions are required. Consult the Agency for appropriate test protocol.
25/ Lactating runinants must be dosed with 0.1, 0.3, and 1.0 ppn pendimethalin (> three animals/dose qroup) in the total
diet until residues plateau in milk or for 28 consecutive days if no residues are detected in milk. Consult the
Aqency for acpropriate test Protocol.
26/ A study on metabolites of pendimethalin in poultry will be required if additional metabolites of concern are
found in the plant metaboli n studies. The need for a poultry feeding study will depend upon the results of a
Poultry metaboli n study.
27/ The following data are required for tobacco: Residue data involving the metabolj of pendijuethal in in tobacco using
radiosotope techniques; and residue data involving pendiii tha1in metabolite(s) in or on green freshly-harvested
tobacco. If residues exceed 0.1 ppn, additional data on yrolysis products must be submitted.
28/ Refer to rice tolerance on page 14/ Data Tables.
46
-------
E ta 1 4uir T nt
S158.130 Envirormental Fate
DFXRA1 TIC*i STUDIES—LAB :
161—1 — Hydrolysis
Photodegradat ion
161—2 — In water
161—3 — soil
161—4 — In Air
METABOLISM STUDIES-LAB :
162—]. — Aerobic Soil
16 2—2 — Anaerobic Soil
162—3 — Anaerobic Pquatic
162—4 — Aerobic Pquatic
f4DBILITY STUDIES :
163-1 — Leachir j and
Msotpt ion/Desorpt ion
— Volatility (Lab)
— Volatility (Field)
Yes 7/
Yes 7/
Yes 7/12/
Yes 7/13/
Yes 7/14/
19(14)
TABLE A
GENERIC [ TA RE JIRF 4FNIS FOR PENDIMEThALIN
I es EPA Have t ta
To Satisfy This
Reguirenent? (Yes,
No or Partially)
Sut itted
Section
1/
Catpc ition
Use 2/
Pattern
Bibliographic
Citation
Under FIFRA
3(c)(2)(B)?
‘IGA! or PAIRA A,B,C
00106777 No
i I or PAIRA
TGAI or PAIRA
‘ IGAI or PAIRA
‘]X? 1 I or PAIRA
‘r AI or PAIRA
‘lX AI or PAIRA
TGAI or PAIRA
A,B,C
A
A
A,B
A
C
C
Yes
No
No
8/
No
No
No
No
No
No
No
163—2
163—3
Yes 6/
Yes 6/9/
Yes 6/10/
Yes 6/11/
1 3AI or PAIRA A,B,C
TEP A
TEP A
47
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TABLE A
Q NERIC 1 1’A RFOUIR ’IF2 ’TS FOR PE )INE1’RALIN
TXes EPA Have Data
TO Satisfy This
Requirement? (Yes,
No or Partially)
Must I 5d [ tiona1
Data Be S.*mitted
Under FIF’RA Section
3(c) (2) (B)?
Subpart R- Reentry
(158.140)
c c!! Pps itiçm
Use 2/
Pattern
Bibi ioaranhic
Citation
Data Requirement
S158130 Envirormental Fate
(continued)
DISSIPATION STUDIES-FlEW :
164—1 — Soil
164—2 — Aauatic (Sediment)
164—3 — Forestry
164—4 — Q nbination and
nk Mixes
164—c — Soil, Long—term
ACQThUIAPICE STUDIES :
165—1 — tationa1 Crops
(c nfined)
165—2 — Wtational Crqus
(Field)
165—3 — Irrigated Crops
165—4 — In Fish
l 5—5 — In uatic ! n-Tarqet
Organi3
w
TEP A,R
TEP C
TEP A,C
PAIRA A,C
TEP A,C
TEP C
1 ? I or PAIPA A,B,C
Yes
Yes 64 /
Yes 17/
Yes
Yes Jl9/
Yes
Yes 2/21/
48
-------
TA&.E A
GfNERIC TA RB JIREMENIS OR PENDIMETHPiLIN
21 (17)
S158.130 EnvircrI nta1 Fate
(contir.ied)
/ Ccmposition: TGAI Technical grade of the active ingredient; PAIRA Pure active ingredient, radiolabelled;
TF P lypical end-use product.
( The use patterns are coded as follcws: A Terrestrial, Food Crc ; B Terrestrial, Non-Food; CPquatic, Food Crcp;
D k1uatic, Non—Food; E=Greenhwse, Food Crc ; F reenhai5e, Non—Food; G Forestry; H=Dc*testic Qjtdoor; I=Indoor.
/ i ta are required and IT ust be submitted no later than April 30, 1989.
/ 1 ta are re:juired and nust be s mitted no later than April 30, 1988.
/ t*ta are required and mist be submitted no later than Oct er 30, 1987.
t ta are required and mist be submitted no later than April 30, 1987.
2( Data are required and mist be submitted no later than October 30, 1985.
/ This caçcund does rot require photodegradation data in air.
2’ Not required if an anaerobic equatic netaboligu study is conducted.
Q/ A netabolia test i.nder anaerobic aiuatic condition is required.
W A net.abolign test under aerobic aquatic condition is required.
12/ A nobility study involving leaching and adsorption/desorptiOfl is required.
f A nobility study involving volatility in the lab is required.
14/ A nobility study involving volatility in the field is required.
/ A soil dissipation study in the field is required.
A dissipation study in uatic (sedii ent) is required.
17/ A long tenn soil dissipation study in the field is contigent upon the results of studies under 162-1 and/or studies
tmder 164—1 and 164—2.
Pin acar,ilation study in rotational crc s (confined) is required.
An accunijiation study in rotational cr s (field) is required.
/ An acom .i1ation study in irrigated cr s (field) is required.
/ An acc .nm.zlation study in fish is required.
22/ Since pendinethalirk is not applied to forest areas, it does rot require forestry dissipation data.
Data on pendinethalin in cclTt)ination and tank mixes are not required at the present tune.
/ Pending the results of other fate studies, an accmulat ion study in uatic non—target organi may be required.
/ Because of its 1c i toxicity category (III) pendinethalin does not require a re—entry interval.
49
-------
Data Reuir nent
S158.135 Toxicology
ACW E TESTING :
81—1 — Acute Oral Toxicity — Rat
81—2 — Acute DernBl Toxicity
81—3 — Acute Inhalation Toxicity
81—4 — Primary Eye Irritation
81—5 — Prin ry Skin Irritation
81—6 — Dern l Sensitization
81—7 — Acute Delayed
Neurotoxicity — Hen
SLJBG11 IC TESTING :
82—1 — 90—Day Feeding —
Rodent
t’bn—rodent (1)g)
82—2 — 21—Day Dermal
82—3 — 90—Day Dern l
82—4 — 90—Day Inhalation — Rat
82—5 — 90—Day Neurotoxicity —
HerVManw l
00026657, 00072802 No
00026657, 00072802
00073342
22(19)
TP BLE A
GENERIC [ 1 TA REWIREMEm’S FOR PENDIMETHALIN
I ,es EPA Have Data
To Satisfy This
Use 2/ Re uiren nt? (Yes,
Patterns No or Partially)
Must %iditional
Data Be Submitted
1/
Bibliographic
Under FIFR Section
Cci position
Citation
3(c)(2)(B)?
No
No
I AI
A,B
Yes
TGAI
A,B
Yes
1 AI
A,B
Yes
IX3AI
A,B
Yes
TGAI
A,B
Yes
1 AI
A,B
No
TGAI
A,B
13/
TG I
A,B
No
Yes
I A I
A,B
Yes
TGAI
A,B
14/
TGkI
A,B
14/
TQ AI
A,B
14/
00026657, 00072802
00026663
00058657
00026663
No
No6/
Yes 3/7/
Yes 4/9/
No 8/
No
50
-------
E ta R uir nent
§158.135 Tbxico1 y
(contirued)
CH1 JNIC TESTING :
83—1 — Chronic Toxicity —
Rodent
Non-rodent (t g)
83—2 - Oncogenicity Study —
2 species: Rat aud
Mcuse preferred
83—3 — Teratogenicity -
Rat
Rabbit
83—4 — Reproduction,
2-generation
L4YFNENICITY TESTING
84—2 — Gene Mutation
84—2 - thrc ir&i l Therration
84—2 - Other Mechania of
titagenicity
23(20)
TABLE A
GENERIC DATA RE JIREMENTE FUR PENDIMETHPLIN
I)es EPA Have I ta
To Satisfy This
1/ Use 2/ R€quire tent? (Yes, Bibliographic
Ccnposition Patterns No or Partially) Citation
ist p 1ditional
E ta Be Subinitted
Under FIFRA Section
3(c)(2)(B)?
A,B
No
-
Yes
• / /
Yes
00058657
No
A,B
No
-
Yes
/ .i/
1XIAI
A,B
Yes
00025752
No
Yes
00117444
No
A,B
Yes
00040304
No
1 A1
A,B
Partially
00067519
Yes
3/12/
TGAI
A,B
Partially
00026673
Yes
3/12/
I AI
A,B
No
Yes
3/12/
51
-------
Data Re uir nent
§158.135 Thxicology
(continued)
SPECIAL TESTING
85—1 — General Metaboli i
85-2 - Dariral Absorption Study
SPECIAL REC JIRE 1ENT
86-1 — Danestic Animal Safety Choice 14/
24 (21)
TABLE A
GENERIC DATA REI UIREMENTS FOR PENDIMETHALIN
1)es EPA Have Data
To Satisfy This
R uireiient? (Yes,
No or Partially)?
Must Mditional
Data Be Sut nitted
1/
Use
2/
Bibliographic
Under FIFRA Section
Ca osition
Pattern
Citation
3(c)(2)(B)?
PAT or PAIRA A,B Yes
15/
00046275 No
52
-------
TABLE A
25(22) GENERIC EY TA RE(JIRE 4F TS FOR PENDIMEThALIN
§158.135 Toxicology
(continued)
1/ Caposition: TGAI = Technical grade of the active ingredient; PAl = Pure active ingredient; PAIRA = Pure active
ingredient, radiolabeled; thoice = thoice of several test substances determined on a case—by—case basis.
2/ The use patterns are coded as fo1lc s: A=Terrestrial, Food Crcp; B=Terrestrial, Non—Food; C=A uatic, Food Crcp;
D=Pquatic, Non—Fbod; E=Greenhcuse, Food Crcç; F=Greenhcuse, Non—Food; G=Forestry; H=Et stic Cxitdoor; I=Indoor.
3/ Data are ra uired and mist be submitted no later than October 30, 1985.
4/ E ta are reuired and mist be submitted no later than January 30, 1986.
5/ Data are r uired and mist be submitted no later than April 30, 1989.
6/ A 21—day subacute dern 1 study in the rabbit is being used to satisfy this acute toxicity reluireltent.
7/ A demal sensitization study in the guinea pig is rejuired.
8/ The chronic dog study satisfies the re uire nt for a subchronic dog study.
9/ A 90-day feeding study in the rat is required because the previcus 90-day study was inadequate.
10/ A chronic toxicity study in rat is required because the previcus 2—year study was revie ed by the Agency and
declared invalid.
11/ An oncogenicity study in both rat and in nouse is required because the previcus oncogenicity studies on the rat and
rwiise re revie d by the Agency and declared invalid.
12/ The fol1c ’iing nutagenicity data are required:
a. Gene nutation in bacteria,
b. Gene nuitation in mamtTalian cells in culture,
c. C 1rc*Tcsa aberration analysis in mammalian cells in culture, and
d. DNA damage in mamualian cells in culture.
13/ Since pendimethalin is not a cholinesterase inhibitor and does not otherwise indicate neurotoxicity, this
data is not required.
14/ The guidelines and uses generally indicate that this data is not required.
15/ The Agency has the cption to request this type of study.
53
-------
Data Requir nent
158.l45 Wildlife and
Aquatic Orqani
AVIAN AND MW LIAN TESrI!
71-1 - Acute Avian Oral Toxicity
71-2 — Acute Avian Dietary
1 xiCity
a) Upland qanebird
b) Waterfowl
71—3 — Wild MalTinal. Toxicity
71-4 - Avian 1 production
71—5 - Simulated and Actual
Field ¶l sting —
Maninals and Birds
P ThTIC O1 ANISM TF ’PIW
72-1 - Acute Fresh ter Fish
Toxicity
a) Warmwater
TABLE A
GENERIC D .TA R JIRF 1ENTS FOR PENDIMErHALIN
tees EPA Have Data
To Satisfy This
1/ Use 2/ Requirenent? (Yes, Biblioqraphic
Canposition Pattern No or Partially) Citation
Must Mditional
Data Be Submitted
Under FIFRA Section
3(c)(2)(B)?
¶1 I
A,B,C
Yes
00059739
T I
A,B
Yes
00026674
No
T I
A,B
Yes
00026675
No
‘1 I
A,B
!/
I
A,B
8/
TEP
A,B
!/
‘ft I
A,B,C
Yes
00106764
TEP
C
Yes
00037927
00131773
TCI’J
A,B,C
Yes
00l067 4
No
TEP
C
Yes
00037927
No
b) 1dwater
54
-------
Data RequireT ent
S158.145 Wildlife and
Aquatic Organi ns
(continued)
72—2 — Acute Freshwater
Invertebrate 1 x icity
72—3 — Acute ‘I’bxicity Estuarine
and Marine Organi s
a) Oyster
T BL A
( NER [ C flkTA RE (JIRF74ENPS FOR PEM)IM VHALIN
I)Des FPA 1ave Data
1 Satisfy This
1 auir nent? (Yes,
No or Partially)
itist iditiona1
Data Be Suhnitted
1/
Use
2/
Biblioarathic
Under FIFRA Section
Cc*Tvositicn
Pattern
Citation
3(c)(2)(B)?
Yes 00071123
00059738
A,B,C
TEP C
A,C
TEP A,C
!I I A,C
‘PEP A,C
A,C
‘rEp A,C
A,C
!t I A,C
A,C N D
C5/
Yes
Yes
Yes
Yes
Yes
Yes
b) Shrinp
C) Marine Fish
72—4 — Aauatic Invertebrate
Life-Cycle
72—5 - Fish — Life—Cycle
72-6 - Aquatic Orqania
Acctxnulation
72—7 — Aquatic Field Stlx y
00131772
00131772
00131775
00131775
00131774
00131774
Yes 3/
4/
4/
4/
Yes
Yes
Yes 00100504
Yes 00037940
55
-------
TABLE A
28(3 1) GENERIC I TA RF UIREMENTh FOR PE DIMEThALIN
I es EPA Have t ta
ist ? dditional
To Satisfy This
I ta Be Submitted
1/
Use
2/
Rejuire nt? (Yes,
Bibliographic
Under FIFRA Section
E ta Requir nent Ca position
Pattern
No or Partially)
Citation
3(c)(2)(B)?
§158.155 ! bntarget Insect
N0NTA1 3ET INSECT TESTI -
POLLINAiO :
141—1 — Honey bee ao.ite A,B Yes 00099890
contact toxicity
141—2 — Honey bee — toxicity TEP A,B 9/
of residues on
foliage
141—4 — Honey bee subaoite [ Reserved] 6/
feeding study
141—5 — Field testing for TEP A,B 2/
pollinators
56
-------
TABLE A
29(32) ERIC I A R JIREMENFS OR P DIME’rH LIN
D es EPA Have t ta
?tist
To Satisfy This
I ta Be
Section
1/
i ta R uira ent Ca osition
Use 2/
Pattern
uirwent? (Yes,
No or Partially)
Bibliographic
Citation -
3(c) (2) (B)?
S158.155 Nontarget Insect
(ccnttrued)
P’rANET INSECT TESTING —
A JATIC INSECTS :
142—1 — Aaite toxicity to
auatic insects
142—2 - k uatic insect
life—cycle study
142—3 — Slnvlated or actual
field testing for
uatic insects
143—1 — to ’rA E’r INSECT
- PRE
thru AND PARASITES
143—3
(Reserved)!/
(Reserved)!!
(Reserved)!!
(Reserved)7/
57
-------
TABLE A
30(33) GENERIC EIkTA RE (JIREMENTS FOR PENDIMEIHALIN
§158.145 Wildlife and Pquatic Organisms
(continued)
1/ Ca position: T ? I = Technical grade of the active ingredient; PAl = pure active ingredient;
TEP = Typical end-use product;
2/ The use patterns are coded as foll is: A=Terrestrial, Food Crcp; B=Terrestrial, Non—Food Crop; CA uatic, Food Crop;
Dkluatic, Non—Food; E=Greenhaise, Food Crcp; F=Greenhwse, Non—Food; G=Forestry; H=Dc stic (Xitdoor; I=Indoor.
3/ This study is rnguired to support the rice use, and nust be submitted by October 30, 1985.
4/ R uir ent pending receipt and revi of environnental fate data in conjunction with such uses as corn,
soybeans and cotton.
5/ This study will nonitor residues in & uatic sites next to rice fields, and nust be submitted by ri1 30, 1987.
6/ Reserved pending develoLeent of test nethodology.
7/ Reserved pending Agencys’ decision as to whether data re uirenent shxxld be established.
8/ The lc i avian and mann lian toxicity data for pendiitethalin indicate that these data are not re uired.
9/ No additional data required because the data shcws pendimethalin to be non-toxic to bees.
58
-------
MP Yes 00106751 ND
MP Partially 00106751 Yes 3/5/
MP ND Yes 3/6/
MP Partially 00046347 Yes 2/7/
MP Partially 00046347 Yes 2/8/
MP Partially 00106751 Yes 3/9/
MP Yes G90187—001 ND
MP Yes ( 0187-001 ND
MP Yes ( 0l87—001 ND
MP Yes ( 0i87—001 No
MP Yes C 0i87—00i ND
MP Yes ( Oi87—001 ND
‘PABLE B
PRCUJC’ SPECIFIC I Th RECIJIR1 74ENPS FOR MN’JJFACVtJRfl -LJSE P1 ))OCFS C(Wii’AINDZ PENUI4F HALIN (9(1% A. I.)
Does EPA Have Data Must P ditiona1
‘i Satisfy This Data Be Subnitted
1/ Requirement? (Yes, Bib lioqrathic Under FIFRA Section
Data Requirement Ccr xsition No or Partially) Citation 3(c)(2)(B)?
1S8.120 Product Chemistry
Product Identity :
61—i - Identity of Ingredients
61—2 — Statement of Cci osition
61-3 - Discussion of Formation of
Ingredients
Analysis and Certification of Product
Ingredients
62—1 - Preliminary Analysis
62—2 — Certification of Limits
62-3 - Analytical Methods for
F forc nt of Limits
Physical and Chemical Characteristics
63—2 - Color
63—3 — Physical State
63-4 - C) or
63—5 — Melting Point
63-6 - Boiling Point
63-7 - Density, Bulk Density, or
Specific Gravity
59
-------
TABLE B
32(36) PRDUCr SPECIFIC DT TA RFX (JIREMENTS FDR M1 NUFAC1Xfl ING-tJSE P1 DDUCTS iNINC PENDIMEflIALI N
— tkes EPA Have Data Must Mditional
To Satisfy This Data Be Submitted
1/ R uireirent? (Yes, Bibliograpriic Under FIFRA Section
Data Re uir nent Caiposition No or Partially) Citation —— 3(c)(2)(B) ? ___
S158.120 Product Chemistry
(continued)
63—12 - pH No Yes 2/
63—14 — Oxidizir j or Reducing No Yes 2/
Action
63-15 — Flamrrability MP No Yes 2/
63—16 — Explod bility No Yes 2/
63—17 — Storage Stability T4P No Yes 4/10/
63-18 - Viscaiity No Yes 2/
63—19 - Miscibility MP No Yes 2/
Other R uirejyents :
64— 1 — Submittal of sa les Choice 11/
60
-------
TABLE B
33(39) H ODUC SPEC I FIC Il TA RFX XJ IREMENTS FOR M UFACI1JRING-USE PFODtX1 S (DNTAINING PFNDIMETHALI N
§158.120 Product Chemis y
(continued)
1/ CcitpositiOfl: MP = Manufacturing—use product; Choice = Choice of several test substances determined on a case—by-
case basis.
2/ t ta are r uired and riust be submitted no later than October 30, 1985.
3/ t ta are rejuired and n ist be submitted no later than April 30, 1986.
4/ ! ta are required and must be submitted no later than July 30, 1986.
5/ The nane and address of the nenufacturer or producer of each starting material used in the 90% technical
product is re3uired.
6/ A discussion of each inpurity believed to be present at >0.1% based on the beginning materials, all chemical
reactions and any contamination.
7/ Five or re sanpies must be analyzed for the active ingredient (A.I.) and each inpurity present for which a certified
limit is required.
8/ A current Confidential Stat nt of Formula must be submitted.
9/ ç iantitative netho to determine the remaining irrpurities in the technical product are required.
10/ The follcwing data are required for chemical stability: discussion of sensitivity of the A.I. to matal and matal ions,
stability of the A.I. at normal and elevated tenperatures, and the sensitivity of the A.I. to sunlight.
11/ This carpound does not re4uire the submittal of sanples.
61
-------
Data Requir nent
158 . 135 Toxic’oioqy
AaYrE TESTI!
81—1 - Acute Oral Toxicity - Rat
81-2 - Acute Detmal Toxicity
81—3 — Acute Inhalation Toxicity
Rat
— Primary Eye Irritation
- Primary Skin Irritation
— Dermal Sensitization
- Acute Delayed
urotoxicity — lien
00026657, 00072802
00026657, 00072802
00073342
00026657, 00072802
00026663
No
No
No
No
Yes 4/2/
TABLE B
F4 DLET SPECIFIC t ’rA R XJIR 74ENTS RDR MANUFACrURIM -t E PRODIX’PS )I IrAINTh 3 PE DIMETfjALIN
1X)es EPA Have Data
To Satisfy This
Requirement? (Yes,
No or Partially)
1/
Must
Data
Additional
Be Sut iüt ted
Biblioqrap jc
Cctnposjtjon
Under
FIFRA
Section
81—4
81—5
81—6
81—7
MP
MP
MP
MP
MP
MP
Yes
Yes
Yes
Yes
Yes
MP
62
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TABLE B
PP( X P SPECIFIC LWPA RR)UIRMFNI’S POP MANUFAC1’uRIF -tJSE P1 )UCI’S D V INING PEND M HP LIN
158 . 135 Toxicology
(continued)
1/ Oinposition: MP = Manufacturing-use product.
2/ Data are required arx must be st±tnitted no later than October 30, 1985.
3/ A 21-day subacute dermal study in the rabbit is being used to satisfy this acute toxicity requirement.
4/ A dermal sensitization study in the guinea pig is required.
5/ Since pendimethalin is not a cholinesterase inhibitor or otherwise indicates neurotoxicity, these data are not
required.
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The extension request should state the reasons why you believe
that an extension is appropriate. While EPA considers your
request, you must strive to meet the deadline for submitting
the required data.
III. REQUIREMENT FOR SUBMISSION OF PRODUCT—SPECIFIC DATA
Note: Unless stated otherwise in Section I, Regulatory
Position and Rationale, this Section apolies only to manufac—
turinq use products, not to end use products.
A necessary first step in determining which statements
must appear on your product’s label is the completion and
submission to EPA of product-specific data* listed on the
form entitled “Product Specific Data Report” (EPA Form
8580—4, Appendix 111—1) to fill “q ps” identified by EPA
concerning your product. tinder the authority of FIFRA Sec.
3(c)(2)(B), EPA has determined that you must submit these
data to EPA in order to reregister your product(s). All of
these data must he submitted not later than six months after
you receive this quidance document.
Table B--Product—Specific Data ReQuirements for Manufacturing
Use Products-—lists the product specific data you must submit.
Data that are required to he submitted are identified in the
column of those tables entitled “Must Data By Submitted
Under 3(c)(2)(B).”
IV. SUBMISSION OF REVISED TJABELING
Note : This section applies to end use products only to the
extent described in Section I (Regulatory Position and
Rationale). Otherwise, the followinq information pertains
exclusively to manufacturing use products.
FIFRA requires each Product to be labeled with accurate,
complete and sufficient instructions and precautions, reflecting
the results of data concerning the product and its inqredierits.
Labeling requirements are Set out in 40 CFR 162.10 (see
Appendix IV—l) and are summarized for products containing
this active ingredient as part of this Guidance Document
(See Appendix IV—2). Applications submitted in response to
this notice must include draft labeling for Agency review.
*1 Product specific data Pertain to data that supoort the
formulation which is marketed: it usually includes product
chemistry data and acute toxicity data.
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If you fail to submit revised labeling information
complying with this section (supplemented by requirements
described in Section I, Regulatory Position and Rationale),
EPA may issue a notice of intent to cancel the registration
under FIFRA Sec. 6(b)(l).
A. Label Contents
40 CFR 162.10 requires that certain specific labeling
statements appear at certain locations on the label. This
is referred to as format labeling . Specific label items
listed below are keyed to Appendix TV-2.
Item 1. PRODUCT NAME - The name, brand or trademark is
required to be located on the front panel, referahly centered
in the upper part of the panel. The name of a product will
not be accepted if it is false or misleadinq.
Item 2. COMPANY NAME AND ADDRESS — The name and address
of the registrant or distributor is required on the label.
The name and address should preferably he located at the
bottom of the front panel or at the end of the label. text.
Item 3. NET CONTENTS - A net contents statement is
required on all labels or on the container of the pesticide.
The preferred location is the bottom of the front panel
immediately above the company name and address, or at the end
of the label text. The net contents must be expressed in the
largest suitable unit, e.g., “1 pound 10 ounces” rather than
“26 ounces.” In addition to English units, net contents may
be expressed in metric units. See Appendix iV—1. [ 40 CFR
162.10(d)]
Item 4. EPA REGISTRATION NUMBER - The reqistratiOn
number assigned to the pesticide product must appear on the
label, preceded by the phrase “EPA Registration No.,” or “EPA
Reg. No.” The registration number must be set in type of a
size and style similar to other print on that part of the
label on which it appears and must run parallel to it. The
reqistratiOn number and the required identifying phrase must
not appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Aqency. See Appendix IV-l.
[ 40 CFR l62.lO(e)1
Item 5. EPA ESTABLISHMENT NtJMBF R - The EPA establishment
number, preceded by the phrase “EPA Est.” is the final estab—
lishment at which the product was produced, and may appear
in any suitable location on the label or immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment number on the immediate
container cannot be clearly read through such wrapper or container.
See Appendix IV—l. [ 40 CFR l62.l0(f)1
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Item 6. INGREDIENTS STATEMENT — An ingredients statement
is required on the front panel. The ingredients statement must
contain the name and Percentage by weight of each active inqredje t
and the total percentage by weight of all inert ingredients.
The preferred location is immediately below the product name.
The inqredjents statement must run parallel with, and he clearly
distinguished from, other text on the panel. It must not be
1aced in the body of other text. See Apnendix TV-i. [ 40 CFR
l62.l0(q) I
Item 6A. OUNDS PER GALLON STATEMENT - For liquid agricul-
tural formulations, the pounds per qallon of active inqredient
must be indicated on the label.
Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS - Front Panel
precautionary statements must be qrouped toqether, preferahl.y
within a block outline. The table below shows the minimum type
size requirements for various size labels.
Size of Label Signal Word “Keep Out of Reach
on Front Panel Minimum Type Size of Children”
in Square Inches All Capitals Minimum Type Size
5 and under 6 point 6 point
above 5 to 10 10 point 6 Point
above 10 to 15 12 point S point
above 15 to 30 14 point io point
over 30 15 point 12 point
Item 7A. CHILD HAZARD WARNING STATEMENT - The statement
“Keep Out of Reach of Children” must be located on the front
panel above the siqnal word except where contact with children
during distribution or use is unlikely. See Aopendjx n i—i.
40 CFR 162.l0(h)(l)(ii)1
Item 7B. SIGNAL WORD - The signal word (DANGER, WARNING,
or CAUTION) is required on the front Panel immediately below
the child hazard warning statement. See Appendix TV—i.
140 CFR 162.10 (h)(1)(i)]
Item 7C. SKULL & CROSSBONES AND WORD “POISON” - On oroducts
assigned a toxicity Cateqory I on the basis of oral, dermal,
or inhalation toxicity, the word “Poison” shall a ear on the
label in red on a background of distinctly contrasting color and
the skull and crossbones shall appear in immediate proximity to
the word POISON. See Appendix IV—l. 140 CFR 162.l0(h)(1)(j)]
Item 7D. STATEMENT OF PRACTICAL TREATMENT - A statement
of practical treatment (first aid or other) shall appear on
the label of pesticide products in toxicity Categories I,
II, and III. See Appendix IV—l. [ 40 CFR 162.lO(h)(].)(jji)]
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Item 7E. REFERRAL STATEMENT — The statement “See Side
(or Back) Panel for Additional Precautionary Statements” is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
See Appendix P T—i. 140 CFR 162.ifl(h)(l)(iii)1
Item 8. SIDF./BACT( PANEL PRECAUTIONARY LABELING — The
precautionary statements listed below must appear toaether
on the label under the heading “PRECAUTIONARY STAPF,MFNTS.”
The preferred location is at the top of the side or back
panel preceding the directions for use, arid it is preferred
that these statements be surrounded by a block outline. Each
of the three hazard warning statements must be headed by the
appropriate hazard title. See Appendix iV—l. [ 40 CFR 162.10
(h) (2)1.
Item BA. HAZARD TO HUMANS AND DOMESTIC ANIMALS — Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicatinq the particular hazard, the
route(s) of exposure and the precautions to be taken to avoid
accident, injury or damaqe. See Appendix iv—1. [ 40 CFR 162.10
(h) (2) ( i)]
Item BR. ENVIRONMENTAL HAZARD - Where a hazard exists to
non-tarqet orqanisms excluding humans and domestic animals,
precautionary statements are required statina the nature of
the hazard and the appropriate precautions to avoid potential
accident, iniury, or damage. See Appendix IV—l. [ 4fl CFR
162.10(h) (2) (ii)]
Item BC. PHYSICAL OR CHEMICAL HAZAPT)
1. Flammability statement . Precautionary statements relating
to flammability of a product are required to appear on the
label if it meets the criteria in Appendix p7—3. The require-
ment is based on the results of the flashpoint determinations
and flame extension tests required to be submitted for all
products. These statements are to be located in the side/back
panel precautionary statements section, preceded by the
headinq “Physical/Chemical Hazards.” Note that no signal
word is used in conjunction with the flammability statements.
2. Criteria for declaration of non—flammability . The
following criteria will be used to determine if a product
is non—flammable:
a. A “non—flammable gas” is a gas (or mixture of gases)
that will not ignite when a lighted match is placed
aqainst the open cylinder valve.
b. A “non—flammable liquid” is one havinq a flashpoint
greater than 350°F (177°C ).
67
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c. A “non—flammah]e aerosol” is one which meets the
following criteria:
i. The flame extension is zero inches?
ii. There is no flashback: and
iii. The flashpoint of the non—volatile liquid
component is greater than 350°F (177°C).
3. Declaration of non-flammability . Products which
meet the criteria for non—flammability specified
above may bear the notation “non—flammable” or “non-
flammable (gas, liquid, etc.)” on the label. It may
appear as a substatement to the ingredients statement,
or on a back or side panel, but shall not he highlighted
or emphasized (as with an inordinately larqe type
size) in any way that may detract from precaution.
4. Other physical/chemical hazard statements . When
chemistry data demonstrate hazards of a physical or
chemical nature other than Flammability, appropriate
statements of hazard will be prescribed. Such statements
may address hazards of explosivitv, oxidizinq or reclucinq
capability, or mixing with other substances to produce
toxic fumes.
Item 9A. RESTRICTED USE CLASSIFICATION — FIFRA sec. 3(d)
requires that all pesticide formulations/uses be classified
for either general or restricted use. Products classified
for restricted use may be limited to use by certified apolicators
or persons under their direct supervision (or may be sublect
to other restrictions that may be imposed by regulation).
In the Registration standard, the Agency has (1) indicated
certain formulations/uses are to be restricted (Section I
indicates why the product has been classified for restricted
use); or (2) reserved any classification decision until
appropriate data are submitted.
The Regulatory Position and Rationale states whether
products containing this active ingredient are classified
for restricted use. If they are restricted the draft label(s)
submitted to the Agency as Part of your application must
reflect this determination (see below).
If you do not believe that your product should be classified
for restricted use, you must submit any information and
rationale with your application for rereqistration. During
the Agency’s review of your application, your oroposed classi-
fication determination will be evaluated in accordance with
the Provisions of 40 CFR l 6 2.ll(c). You will be notified of
the Agency’s classification decision.
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A. Classification Labe].inq ReauiremefltS
If Section I of this Guidance Document indicates that
your product has been classified for restricted use, the
following label requirements apply:
1. Front panel statement of restricted use classification.
a. The statement “Restricted Use Pesticide” must
appear at the top of the front panel of the label.
The statement must be set in type of the same
minimum size as required for human hazard signal
word (see table in 40 CFR 162.l0(h)(l)(iV)
b. Directly below this statement on the front panel,
a summary statement of the terms of restriction must
appear (inciudinq the reasons for restriction if
specified in Section I). If use is restricted to
certified applicators, the followiriq statement is
required: “For retail sale to and use only by
Certified Applicators or persons under their direct
supervision and only for those uses covered by the
Certified Applicator’s Certification.”
2. Some but not all uses restricted. If the Regulatory
position and Rationale states that some uses are classified
for restricted use, and some are unclassified, several courses
of action are available:
a. You may label the product for Restricted use.
If you do so, you may include on the label uses that
are unrestricted, but you may not clistinquish them
on the label as being unrestricted.
b. You may delete all restricted uses from your
label and submit draft labeling beaririq only unrestricted
uses.
c. You may “split” your registration, i.e., register
two separate products with identical formulations, one
bearing only unrestricted uses, and the other bearing
restricted uses. To do so, submit two applications for
ereqistratiOn, each containing all forms and necessary
labels. Both applications should he submitted simul-
taneously. Note that the products will, be assigned
separate registration numbers.
69
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B. Compliance Schedules
No product with a use classified for restricted use
under this Standard may be released for shipment by the
reqjstran or producer after one year from the date of
issuance of this Standard, unless such product bears the
restricted use classification. All products still i.n
channels of trade after two years from the date of issuance
of this Standard must be labeled for restricted use.
Item B. (There is no Item 9B].
Item 9C. MISUSE STATEMENT — All products must bear the
misuse statement, “It is a violation of Federal law to use
this product in a manner inconsistent with its labeling.”
This statement appears at the beginning of the directions
for use, directly beneath the headinq of that section.
Item bA. REENTRY STATEMENT - If a reentry interval
has been established by the Agency, it must be included on
the label. Additional worker protection statements may be
required in accordance with PR Notice 83—2, March 29, 1983.
Item lOB. [ There is no Item lOBj.
Item lOC. STORAGE AND DISPOSAL LOCT< - All labels are
required to bear storage and disposal statements. These
statements are developed for specific containers, sizes, and
chemical content. These instructions must be qrouped and
aøpear under the heading “Storace and Disposal” in the directions
for use. This heading must be set in the same type sizes as
required for the child hazard warninq. Refer to Appendix
IV-.4 to determine the disposal instructions appropriate for
your products.
Item 1OD. DIRECTIONS FOR USE — Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide. When followed, directions must be adequate to
protect the public from fraud and from personal in-jury and to
prevent unreasonable adverse effects on the environment. See
Appendix iv—i. [ 40 CFR 162.10]
B. Collateral Labeling
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, or other graphic printed matter which is referred to
on the label or which is to accompany the product are termed
collateral labeling. Such labeling may not bear claims or
representations that differ in substance from those acceotec3
in connection with registration of the product. It should be
made part of the response to this notice and submitted for
review.
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V. INSTRUCTIONS FOR SUBMISSION
All applications prepared in response to this Notice should
be addressed as follows:
Robert J. Taylor
Registration Division (TS—767C)
Office of Pesticide Programs
Environmental Protection Agency
Washington, D.C. 20460
Phone No. (703)557—1800
A. For Manufacturing Products (MP) containing (Pendimethalin
as an active inqredient .
1. Within 90 days from receiot of this document, you must
submit the “FIFRA Section 3(c)(2)(B) Summary Sheet t ’ EPA Form
R580-l. Refer to Appendix 11—3 with appropriate attachments.
2. Within 6 months from receipt of this document you must
submit:
a. Confidential Statement of Formula, EPA Form 8570-4.
b. Product Specific Data Report, EPA Form 8580—4
(Appendix 111—1).
c. Two copies of any required product-specific data.
d. Two copies of draft labeling, including the label and
associated brochures. If current labeling conforms to the
requirements of this guidance document and the results of
the short—term data, you may submit such labeling. End use
product labeling must comply specifically with the instructions
in Section i (Regulatory Position and Rationale) of this
guidance document. The labeling should be either typewritten
text on 8-1/2 x 11 inch paper or a mockup of the labeling
suitable for storage in 8—1/2 x 11 inch files. The draft
label must indicate the intended colors of the final label,
clear indication of the front panel label, and the intended
type sizes of the text.
e. Evidence of compliance with data support requirements
of FIFRA sec. 3(c)(1)(D). Refer to PR Notice 84—4 (enclosed)
for latest requirements.
3. Within the times set forth in Table A , all generic data
must be submitted.
71
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Note : If for any reason any required test is delayed or
so that the aqreed schedule cannot be met, notify
the Product Manaqer.
B. For Manufacturjnq Use Products containinq (Pendimethaljn)
in combination with other active inqredier s
1. Within 90 days from receipt of this document, you must
submit tEe “FIFRA Section 3(c)(2)(B) Summary Sheet,” EPA Form
8580—1. Refer to Appendix 11-3 with aporoprjate attachments.
2. Within the times set forth in Table A , all generic data
must be submitted .
Note: If for any reason any required test IS delayed or
aborted so that the agreed schedule cannot be met, notify
the Product Manager.
C. For End Use Products containing (name of Pesticide) alone
or in combination with other active inqredjent
1. Within 90 days from receipt of this document, you must
submit the “FIFRA Section 3(c)(2)(B) Summary Sheet,” EPA Form
8580—1. Refer to Appendix 11-3 with appropriate attachments.
2. Within 6 months from receipt of this document you must
submit:
a. Confidential Statement of Formula, EPA Form 8570—4.
b. Product-Specific Data Report, EPA Form 8580—4
(Appendix 1 1 1-1).
c. Two copies of any required product-specific data.
(Refer to Table C).
d. Two copies of draft lahelinq, includinq the label and
associated brochures. If current labeling conforms to the
requirements of this guidance document and the results of
the short—term data, you may submit such labeling. End use
product labeling must comply sPecifically with the instructions
in Section I (Regulatory Position and Rationale) of this
guidance document. Labeling should be either typewritten
text on 8 1/2 x 11 inch paper or a mockup of the labeling
Suitable for storage in 8 1/2 inch files. The draft label
must indicate the intended colors of the final label, clear
indication of the front panel label, and the intended type
sizes of the text.
e. Evidence of compliance with data support requiremen
of FIFRA sec. 3 (c)(l)(D). Refer to PR notice 84—4 (enclosed)
for latest requiremen
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3. For those end use product registration that are not
eligible for the formulator’s exemption, submit all generic data
within the time set forth in Table A.
D. For intrastate products containing (Pendimethalin)
either as the sole active ingredient or in combination
with other active ingredients .
These products are being called in for full Federal
registration. Producers of these oroducts are being sent
a letter instructing them how to submit an application for
registration.
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Appendix u-i
Guide to Use of This Ribiioqraphy
1. CONTENT OF BIBLIOGRApHy. This bibliography contains
citations of all studies considered relevant by PA in
arriving at the positions and conclusions stated elsewhere
in the Standard. Primary sources for studies in this
bibliography have been the body of data submitted to EPA
and its predecessor agencies in support of past requlatory
decisions. Selections from other sources including the
published literature, in those instances where they have
been considered, will be included.
2. UNITS OF ENTRY. The unit of entry in this bibliography
is called a “study.” In the case of Published materials,
this corresponds closely to an article. In the case of
unpublished materials submitted to the Agency, the Agency
has sought to identify documents at a level parallel to
the published article from within the tyPically larger
volumes in which they were submitted. The resulting
“studies” generally have a distinct title (or at least a
sinqie subiect), can stand alone for purposes of review,
and can be described with a conventional bibliographic
citation. The Agency has attempted also to unite basic
documents and commentaries upon them, treatinq them as a
single study.
3. IDENTIFICATION OF ENTRIES. The entries in this bibliography
are sorted numerically by “Master Record Identifier,” or
MRID, number. This number is unique to the citation, and
should be used at any time specific reference is required.
It is not related to the six—digit “Accession Number”
which has been used to identify volumes of submitted
studies: see Paraqraph 4(d)(4) below for a further explana-
tion. In a few cases, entries added to the bibliography
late in the review may be preceded by a nine—character
temporary identifier. These entries are listed after
all MRID entries. This temporary identifier number is
also to be used whenever specific reference is needed.
4. FORM OF ENTRY. In addition to the Master Record Identifier
(MRID), each entry consists of a citation containing
standard elements followed, in the case of material
submitted to EPA, by a description of the earliest known
submission. Bibliographic Conventions used reflect the
standards of the American National Standards Institute
(ANSI), expanded to provide for certain special needs.
74
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Appendix TI—i (continued)
a. Author. Whenever the Aqency could confidently identify
one, the Agency has chosen to show a personal author.
When no individual was identified, the Agency has
shown an identifiable laboratory or testing facility
as author. As a last resort, the Agency has shown
the first submitter as author.
b. Document Date. When the date appears as four digits
with no question marks, the Agency took it directly
from the document. When a four—digit date is followed
by a question mark, the bibliographer deduced the
date from evidence in the document. When the date
appears as (14??), the Agency was unable to determine
or estimate the date of the document.
c. Title. In some cases, it has been necessary for
Agency biblioqrapherS to create or enhance a document
title. Any such editorial insertions are contained
between square brackets.
d. Traiiinq parentheses. For studies submitted to the
Agency in the past, the trailing parentheses include
(in addition to any self—explanatory text) the fol-
lowing elements describing the earliest known submission:
(1) Submission Date. The date of the earliest known
submission appears immediately following the word
“received.”
(2) Administrative Number. The next element,
immediately following the word “under,” is the
registration number, experimental use permit
number, petition number, or other administrative
number associated with the earliest known submission.
(3) Submitter. The third element is the submitter,
following the phrase “submitted by.” When
authorshiP is defaulted to the submitter, this
element is omitted.
(4) Volume Identification (Accession Numbers). The
final element in the trailing parentheses
identifies the PA accession number of the volume
in which the original submission of the study
appears. The six—digit accession number follows
the symbol “CDL,” standing for “Company Data
Library.” This accession number is in turn
followed by an alphabetic suffix which shows the
relative position of the study within the volume.
For example, within accession number 123456, the
first study would be l2345 —A: the second, l2345 —
B: the 26th, 123456—Z: and the 27th, 123456AA.
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Pendimethalin Standard (108501)
00018997 Smith, 1.; Lignowski, E.; Coble, H.D. : et al. (1978) Summary: Prowl
(CL 92,553) plus Cotoran (Flucineturon) Pre erqence Tank Mix—
ture——Sojl and Cottonseed Residues. (Unpublished study received
Sep 11, 1978 under 241—243; prepared in cooperation with North
Carolina State Univ., Crop Science Dept., Upper Coastal Plain
Research Station, sutmitted by American Cyanamid Co., Princeton,
N.J.; CDL: 235084—B)
00019004 Boughton, p. (1974) CL 92,553: Determination of N—(1-Ethy1pt-oøy1)
3,4—dimethyl—2,6—dinjtrobenzenamjne in Cottonseed Meal. Method
M—524 dated Jun 2R, 1974. (Unpublished study received SeP 12,
197A under 241—243; suI nitted by American Cyanamid Co., Prince-
ton, N.J.; CDL:235084—I)
00023780 Wyckoff, J.C., Thndreau, R.E. (1974) Prowl (CL 92,553): The Gas
thrcinatoqraphic Determination of CL 9 2,553...and CL 202,347...
Residues in Corn (Foliaqe), Soybean (Foliage) and ? eat (Foli-
age) and CL 92,553 in Soil: Report No. C—454. Summary of
studies 094474—C through 094474—E. (Unpublished study received
Sep 27, 1974 under SF1556: sutmitted by American Cyanamid Co.,
Princeton, N.J.; cDL:094474—B)
00023781 Wyckoff, J.C. (19??) CL 92,553: Determination of N—(l—EthylproWl)_
3,4-dimethyl—2,6--dinjtrobenzamjne in Corn Plants. Undated meth-
od M—458.1. (Unpublished study received Sep 27, 1974 under
5Fl556; sutmitted by American Cyanamid Co., Princeton, N.J.;
CDL: 094474—C)
00023782 Wyckoff, J. (1974) CL 92,553: Determination of N—(l—Ethylpropjl)—3,
4-disnethyl—2,6-dinitrobenzenamine in corn Grain. Undated meth-
od M—465.1. (Unpublished study received Sep 27, 1974 under
5F1556; sutmitted by American Cyanamid Co., Princeton, N.J.;
CDL:094474—E)
00023786 Wyckoff, J.C.; Bodnarchuk, D.; Potts, C.; et al. (1974) Prowl (CL
92,553): Determination of CL 92,553...and CL 2 O2,347...Residue
in Field Corn Tissues (Grain and Foraqe): Report No. C—457.
(Unpublished study received Sep 27, 1974 under 5F1556: sutmitted
by American Cyanamid Co., Princeton, N.J.; CDL:094474—K)
00023787 Wyckoff, J.C.: Bodnarchuk, D.; Potts, C.; et al. (1974) Prowl (CL
92,553): Determination of CL 92,553...and CL 202 , 34 7...Resicjue
in Field Corn Tissues (Grain and Forage): Report No. C—459.
(Unpublished study received Sep 27, 1974 under SF1556: sutmjtted
by American Cyanamid Co., Princeton, N.J.: CDT :094474—L)
76
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00023788 Bodnarchuk; Wyckoff, J.C.; Nzewi, G.I. (1974) Prowl (CL 92,553):
Determination of CL 92,553...and CL 202,347...ReSidUeS in Field
Corn Tissues: Report No. C-450. (Unpublished study received Sep
27, 1974 under 5Fl556; suktnitted by American Cvanamid Co.,
Princeton, N.J.; CDL:094474-M)
00023789 Wyckoff, J.: Bodnarchuk, 1).; Moyer, M., et al. (1q74) Prowl (CL
92,553): Determination of CL 92,553..., CL 202, 347..., tra—
zine....and Bladex...ReSidUeS in Corn Tissues: Report ND. C—456.
(UnpubliShed study received Sep 27, 1974 under 5F1556 : sutiTtitted
by American Cyanamid Co., Princeton, N.J.; CDL:094474-N)
00023790 Wyckoff, J.C.; Bodnarchuk, D. Nzewi, G.I. (i 74) Prowl (CL
92,553): Determination of CL 92,553..., CL 202,347..., Atra—
zine...ancl Blac3ex. ..ResidueS in Field Corn Tissues: Report
No. C—460. (Unoublished study received Sep 27, 1974 under
SF1556: su itted by American Cyanamid Co., Princeton, N.J.;
(DL: 094474—0)
00023791 Moyer, M.: Potts, C.; Bodnarchuk, D., et al. (1974) prowl (CL
92,553): DeterminatiOn o CL 92,553..., CL 202,347..., and
Atrazine...and Bladex...ReSidUeS in Field Corn Tissues:
Report No. C—46l. (UnpubliShed study received Sep 27, 1974
under 5F1556; sulxnitted by American Cyanamid Co., Princeton,
N.J.; cDL:094474—P)
00023792 Moyer, M.: Potts, C.; Wyckoff, J.C; et al. (1974) prowl (CL
92,553): Determination of CL 92,553..., CL 202,347..., Atra—
zine...ResidUeS in Field Corn Tissues: Report No. C—463. (Un-
published study received Sep 27, 1974 under 5F1556; sulinitted
by American Cyanamid Co., Princeton, N.J.; CDL:094474Q)
00023793 Moyer, M.; Potts, C.; Wyckoff, J..C.: et al. (1974) Prowl (CL
92,553): DeterminatiOn of CL 92,553..., CL 202,347..., Atra—
zine...and Bladex...ReSidUeS in Field Corn Tissues: Report
No. C—464. (UrnxlbliShed study received SeP 27, 1974 under
5F1556; sutinitted by American Cyanamid Co., Princeton, N.J.;
CDL: 094 474—R)
00023794 Wyckoff, J.C. : Moyer, M.: Potts, C.; et al. (1.974) prowl (CL
92,553): Determination of CL 92,553..., CL 202,347..., Atra—
zine...and Bla5ex...ReSidueS in Field Corn Tissues: Report
No. C—4(5. (Unpublished study received Sep 27, 1974 under
SF1556; su *n1tted by American Cyanamid CO., Princeton, N.J.:
(DL: 094474—S)
77
-------
00023795 Wyckoff, J.C . Bodnarchujc, D.• Moyer, M.; et al. (1974) Prowl (CL
92,553): Determination of CL 92,553..., CL 202,347..., Atra—
zine...and Bladex...Resicjues in Field Corn Tissues: Report
No. C—466. (Unpublished stuc5v received Sep 27, 1974 under
5F1556 : submitted by American Cyananiid Co., Princeton, N.J.:
CDL: 094474—T)
00023796 Pondreau, R.E. (1973) CL 92,553: Determination of N—(l—F.thyipro , .1)_
3, 4—d imethyl-2 ,6-din itrobenzenamine Residues in Milk: Report
No. C—384. (Unpublished study received Sept. 27, 1974 under
SF1556: submitted by American Cyanarnjd Co., Princeton, N.J.:
CDL: 094474—u)
00024823 Fink, R. (1975) Final Report: 21—Day Cataract Fvaluati.on Study in
the Mallard Duck Usinq Technical Butralin: Project No. 113—111.
(Unpublished study includjnq unofficial analytical report, re-
ceived Nov 17, 1975 under 264-297: prepared by Pruslow Farms,
Inc., submitted by Union Carbide Agricultural Products Co.,
Ambler, Pa.; CDL:225999—A)
00025752 Wolfe, C.W.; Mistrettal, L.H. : Kapp, R.W., Jr. (1979) Oral Teratol-
ogy Study in Rats: AC 92,553: Final Report: Project No. 362-
155. Includes methods M—830 dated Nov 18, 1977 and C—l648 dated
Dec 13, 1979. (Unpublished study including appendix by sui:zi it—
ter, received Jan 14, 1980 under 241—243; prepared in coopera-
tion with Razieton Laboratories America, Inc., submitted by
American Qrananüd Co., Princeton, N.J.: CDr :241595—A)
00025818 Bouqhton, P.J.; Mover, M.: Kust, C.A.: et al. (1976) Residues of
Prowl Herbicide and Its Metabolite in Cotton and Soybeans. (Un—
published study received Feb 13, 1980 under 241-243; prepared in
cooperation with Univ. of North Carolina and others, submitted
by American Cyanamid Co., Princeton, N.J.: Q)L:24178l-A)
00025820 Wyckoff, J.C. (1974) CL 92,553: Determination of N—(1—Ethylprooyl)—
3 , 4 -dinethy1—2,6 dinjtrObenzenamjne in Soybean Plants. Method
M—4R3.1 dated Jul 23, 1974. (Unpublished study received Feb 13,
1980 under 241—243; subnjtted by American Cvanamjd Co., Prince-
ton, N.J.• CDL:241781—C)
00025821 Bohn, W.R. (1974) CL 92, 553: Determination of N—(1—Ethylpropy l) —3,
4 -dimethyl-2,6 dinitrobenzenajnjne in Soybean Seed. Method
M-533 dated Jul 30, 1974. (Unpublished study received Feb 13,
1980 under 241—243: submitted by American Cyanamid Co., Prince-
ton, N.J. CDL:24178l—D)
00025822 Boughton, P.J. (1974) CL 92,553: Determination of N—(l—Ethylpro—
pyl ) — 3 , 4 -diii ethy1-2,6 -dinjtrobenzenajnjne in Soybean Green Seed.
Method M-56() dated Nov 12, 1974. (Unpublished study received
Feb 13, 1980 under 241—243; submitted by American Cyanamid Co.,
Princeton, N.J.; CDL:24178 1—E)
78
-------
00025R27 Bohn, W.R. (1974) CL 202,347: DeterminatiOn of 4— (l—F,thvlprOWl)
amino 2_methv1_3,5_diflitr0-beflZYl alcohol in Soybean Seed.
Method M—53 dated Auq , 1974. (UnpubliShed study received
Feb 13, 1980 under 241—243; sutmittecl by American Cyanamid Co.,
Princeton, N.J.; CDL:241781—K)
00025A28 Boughton, p. (1975) CL 202,347: DeterminatiOn of 4— (1—F thylPrOPYI)
mino_2_methV1-3,5dinitr Yl alcohol in Soybean Oil.
Method M-603 dated Apr 24, 3975. (Unpublished study received
Feb 13, 1980 under 241—243; subnitted by American Cyanamid Co.,
Princeton, N.J.: CDL:241781—M)
00025831 American O ranamid cc*npafly (1974) CL 92,553: DeterminatiOn of N—(l—
EthyiprOoyl )—-3, 4 imethy1_2,6_dinitrobenzenami in Cottonseed.
Method M—476.1 dated Jun 6, 1974. (Unpublished study received
Feb 13, 1980 under 241—243: CDL:241781—R)
00025832 Bouqhton, P.J. (1974) CL 92,553: DeterminatiOn of N—(1—Ethylpro--
l)_3,4_dimethy1_2,6_dinitr0ben na1 i in Cottonseed Oil.
Method M—514 dated May 24, 1974. (UnpubliShed study received
Feb 13, 1980 under 241—243: suhnitted by American Cyanamnid Co.,
Princeton, N.J.; CDL:241781-S)
00025833 lRouqhtOn, P.3. (1974) CL 92,553: DeterminatiOn of N—(l—EthylPrO—
oyl )—3, 4—diinethvl—2 , 6_dinitrObenZefl fline in Cotton Plants.
Method M—S 16 dated June 5, 1974. (UnpubliShed study received
Feb 13, 1980 under 241-243, su nitted by American Cyananid Co.,
Princeton, N.J.: cDL:2417A1-’V)
00025837 Bouqhton, P.J. (1974) CL 202,347: Determination of 4—(1—EthviprO—
py1)aminO-2methYl 3 5-dinitrO4DeflzYi alcohol in Cottonseed.
Method M—523 dated May 24, 1974. (Unpublished study received
Feb 13, 1980 under 241—243: suI itted by American Cyanamid Co.,
Princeton, N.J.: CDL:241781—X)
00026657 Morici, I.J. Alford, B.T.; Babcock, C.N.; et al. (1972) Toxicity
Data for Technical Prowl on Animals: Report A-72-4. (Unpib-
lished study received on unknown date under 4(31451; sutinitted
by American Cyanamid Co., Princeton, N.J.; CDL:093868—F)
00026663 Feirinafl, H. (1973) Report: 21—Day Subacute Dermal Toxicity in Rab-
bits of AC-92553: Laboratory No. 1613. (UnpubliShed study re-
ceived on unknown date under 4(31451; prepared by Food and Drug
Research Laboratories, Inc., suttnitted by American Cyanamid Co.,
Princeton, N.J.: CDL:093868—L)
00026673 Bailey, D.E.; Morgareidge, K. (1973) Daninant Lethal Study in Rats
with AC 92553: LaboratOry No. 2006. (UnpubliShed study received
on unknown date under 4G1451, prepared by Food and Drug Research
Laboratories, Inc., suhinitted by American Cyanamid Co., PriflCe
ton, N.J.; CIT)L:093868—V)
79
-------
00026674 Fink, R. (1973) Final Report: Eiqht—Day Dietary C50 Mallard
Ducks: Prolect No. 362—138. (Unpublished study received on un-
known date under 4Gl45l ; prepared by Hazieton Laboratories,
Inc., sutinilteci Jy ’ American Cyananiid Co., Princeton, N.J.;
CDL: 093868—x)
00026675 Fink, R. (1973) Final Report: Eight—Day Dietary LC5O Bobwhite
Quail: Prolect No. 362-137. (Unpublished study received on un—
known date under 4G1451; prepared by Hazieton Lahoratories, sub—
mitted by American Cyanamid Co., Princeton, N.J.; CDL: 093868—y)
00029018 Wyckoff, J. (1973) CL 202—347: Determination of 4—(l—Ethylpro—
pyl)amino—2—methyl—3,5 -dinitro benzyl alcohol in Corn Plants.
Method M—459 dated Sep 25, 1973. (Unpublished study received on
unknown date under 4G1451: submitted by American Cyanamid Co.,,
Princeton, N.J.; CDL:093869—C)
00029020 Wyckoff, J. (1973) CL 202—347: Determination of 4—(l—Ethylpro—
iq1 ) amino-2 -methyl—3, 5-dini tro—benzvi alcohol in Corn Grain.
Method M—466 dated Ck t 16, 1973. (Unpublished study received
on unknown date under 4G1451; submitted by American Cyanamid
Co., Princeton, N.J.: CDL:093869—E)
00029028 Wyckoff, J.C.: Bodnarchuk, 0.; Van Scoik, W.S. (1973) Prowl (CL
92,553): Determinaton of CL 92,553...arxj CL 2 02,347...Resjdues
in Field Corn Plants: Report No. C—382. (Unpublished study
received on unknown date under 4(11451: submitted by American
Cyanarnid Co., Princeton, N.J.; CDL!093869-N)
00029029 Wyckoff, J.C.; Moyer, M.; Bodnarchuk, D.; et a].. (1973) Prowl (CL
92,553): Determination of CL 92,553...Ct 2 20 2,347...Atra—
zine...and Bladex...Residues in Field Corn Tissues (Fodder and
Grain): Report No. C—401. (Unpublished study received on un-
known date under 4G1451 ; submitted by American Cyanarnid Co.,
Princeton, N.J.; CDL:093869-O)
00029801 Boughton, P.J.; Moyer, M.; gust, C. ., et al. (1974) Prowl
(CL 92,553): Determination of CL 92,553 :N—(1—Ethylpro r1)
- 3 , 4 -du ethy1—2,6-dinjtrobenzena j and CL 202,347 4—(Ethyl—
propylanino) -2—methyl—3 , 5-d initro—benzyl alcohol Residues in
Soybean Seeds. Alabama. 1973: Report No. C—542. (Unpublished
study includinq report nos. C—544, C—543, C—548..., received Dec
21, 1974 under 5G1580; submitted by American Cyanamid Co.,
Princeton, N.J.; CDL:09433].—K)
00029803 Marei, A.H.; Eisner, S.K. (1974) Prowl Soybean Metaboli n:
Residual Radioactivity in Soybean Pods and Plants Grown in Soil
Preated with Carbon—14 Labeled CL 92,553: Report No. C-53R.
(Unpublished study received Dec 21, 1974 under 5G1580; submitted
by American Cyanamid Co., Princeton, N.J.; CDL:094331—M)
80
-------
00030697 Suzuki, H.K.: 1nitacre, D.M.: Anderson, R.F.: et al. (1976) Resi-
due Project 75-1- - I ), Banvel Corn—Harvest Aid. (Unpublished
study received Auq 30, 1979 under 876—25: prepared in coopera-
tion with International Research and DeveloPlient Corp. arid ABC
Lalxratories, sut nitted by Velsicol th nical Corp., thicago,
Ill.; cDL:240896—A)
00031212 Manuel, A.; Zulalian, J.; Steller, W. (1980) Residues of Prowl Her-
bicide and Metabolites in Peanut Hulls: Report b. C—1645.l.
S .minary of studies 099395—B thrauqh 099395—F. (Unpublished
study received Apr 29, 1980 under 241—243: sutnitted by American
Cyanamid Co., Princeton, N.J. CDL:099395-A)
00031214 Smith, J. (1979) Prowl Peridijnethalin (CL 92,553): Validation
of GC Method M-1029 for the Determination of CL 2l7,i4 and CL
202,347 Residues in Peanut Hulls: Report 1’ . C—1618. Includes
method M—1029 dated Oct 11, 1979. (UnpubliShed study received
Apr 29, 1980 under 241-243: su iiittnd by American Cyanamid Co.,
Princeton, N.J.: CDL:099395-C)
00031215 Smith, J.; Lignowski, E.M.: Dunn, J.C.: et al. (1979) Prowl
Pendimethalin (CL 2,553/4E): Residues of CL 92,553, CL 202,347
and CL 217,146 in Peanut Hulls: Report T iD. C—1620. (unpubliShed
study received Apr 29, 1980 under 241—243: sulinittei by American
Cyanainid Co., Princeton, N.J.; CDL:099395-D)
00031216 Smith, J.; Liqnowski, E.M.; Walls, F.R., Jr.; et al. (1979)
Prowl Pendimethalin (CL 92,553/4E): Residues of CL 92,553,
CL 202,347 and CL 217,146 in Peanut Hulls: Report 1 . C—l63l.
(UnpubliShed study received Apr 29, 1980 under 241—243: subnit—
ted by American Cyanamid Co., Princeton, N.J.: CDL:099395—E)
00031217 Smith, J.; LignOWSki, E.M.; Goddard, G.; et al. (1979) Prowl
peridjinethalin (CL 92,553/4E): Residues of CL 92,553, CL 202,347
and CL 217,146 in Peanut Hulls: Report No. C—l628. (Unpublished
study received Apr 29, 1980 under 241—243: subnitted by American
Cyanamid Co., Princeton, N.J.: CDL:099395F)
00031219 Marei, A,H.; Barrinqer, D.P., Jr.: Eisner, S.K. (1975) CL 92,553:
Metabolism XVI: Residual Padioactivity in Peanut Seeds and Foil-
aqe GrMn in Soil Treated with Carbon-14 Labeled Prowl Her-
bicide--PD-M Volume 12: prolect No. 2—460. (UnpubliShed study
received Apr 29, 1980 under 241—243; subnitted by American Cya-
narnid Co., Princeton, N.J.: CDL:0993951)
81
-------
00037927 Bentley, R.E. (1974) Acute Toxicity of Prowl 3T , Prowl 4E, and
Avenge 2A—S to Bluegill (Lepai is macrochirus) and Rainbow
Trout (Salmo qairdneri). (Unpublished study received lNbv
14, 1975 under 6F1703: prepared by BionCTnics, EG&G, Inc.,
submitted by American Cyanamid Co., Princeton, N.J. CDL:
094732—H)
00037940 EG&G Bion ics (1975?) thronic Toxicity of CL—92,553 to the Fat-
head Minnow (Pimephales prc*i elas). (Unpublished study re-
ceived Sep R, 1977 under 241—243; submitted b. ’ American Cyanamid
Co., Princeton, N.J.; CDL:09 342— )
00039519 Bouqhton, P.1.; Potts, C.R. (1975) Prowl (CL 2,553): The (‘,as
throiiatoqraphic Determination of CL 92,553 N—(1—Ethylpropyl)--3,
4 1 imethyl—2,6—dinitrobenzenamine and CL 202,347 4—(l—Ethvl—
propyl amino)-2--methyl--3,5--dinitrobenzyl alcohol fran Fortified
Lima Bean Tissues (Foliage, Pods and Beans): Report No. C—793.
(Unpublished study received Feb 9, 176 under 6G1739; submitted
by American Cyanamid Co., Princeton, N.J.; CDL:095485—D)
00039520 Boughton, P.J. (1975) CL 92,553: Determination of N—(1—Ethylpro--
pyl)—3,4-dimethyl—2,6-dintrobenzenajiijne in Lima Beans. Method
no. M—607 dated Jun 9, 1975. (Unpublished study received Feb 9,
1976 under 6G1739; submitted by American Cyanamid Co., Prince-
ton, N.J.; ( DL:095485—E)
00039522 Boughton, P.J. (1975) CL 202,347: Determination of 4—(1—Ethyl—
propyl) amino—2—methyl-3 , 5—dinitro benzyl alcohol in Lima Bean
Foliage and Pods. Method no. M—610 dated Jun 9, 1975. (Unpub-
lished study received Feb 9, 1976 under 6G1739; submitted by
American Cyanamid Co., Princeton, N.J.; CDL:095485-lj)
00039526 Boughton, P.J.: Devine, J.M.; LapDrata, M. (1975) Prowl (CL
92,553): The Gas thranatoqraphjc, Determination of CL 92,553
N-(l—Fthylpropyl)—3,4- ethy1_2,6_< jnjtrobenzenamjne and
CL 202,347 4—(Ethylpropyi. amino)—2—methyl—3,5-dinitrobenzyl
alcohol frcm Fortified Potato Tissues (Tubers and Vines): Re-
port No. C—786. Includes method no. M—613 dated Jun 23, 1975.
(Unpublished study received Feb 9, 1976 under 6G1739, submitted
by American Cyanamid Co., Princeton, N.J.; CDL:095485-L)
00039527 Boughton, P.J. (1975) CL 92,553: Determination of N(1—F thylpro—
pyl)-3, 4-dimethyl—2, 6-dinitrobenzer aj jne in Potato Vines.
Method no. M—614 dated Jun 23, 1975. (Unpublished study re-
ceived Feb 9, 1976 under 6G1739; submitted by American Cyanamid
Co., Princeton, N.J.; CDL:095485—M)
82
-------
00039528 Boughton, P. (1975) CL 2(12,347: DeterminatiOn of 4—(1—EthY1PrOPY1)
amino 2 -rnethyl-3,5diflitr0 benzyl alcohol in Potato Tubers.
Method no. M-615 dated Jun 23, 1975. (Unpublished study re-
ceiv’ed Feb 9, 1976 under 6G1739: sut nitted by American Cyanamid
Co., Princeton, N.J.; CDL:09 5485—N)
00039535 Pdams, C.F. : Eisner, S.K. (1975) Prowl Herbicide Liina Bean
Metabo1i 11: Residual Radioactivity in Lima Bean pods and Plants
Grown in Soil Treated with Carbon-14 Labeled Prowl: Report
No. C—729. (Unpublished study received Feb 9, 1976 under
6G1739: sulmittecl by American Cyanaiuid Co., Princeton, N.J.;
CDL: 095485—U)
00039537 Adams, C.F.: Eisner, S.R. (1975) Prowl Herbicide, Potato Me—
taboli : Residual Radioactivity in Potato Plants Grown in Soil
Treated with Carbon-l4 Labeled Prowl: Report No. C-728. (Unpub-
lished study received Feb 9, 1976 under 6G1739 ; suttnitted by
American Cyanamid Co., Princeton, N.J.; CDL:095485-X)
00040304 Papp, W.R.; KaSner, J.A.; Wilson, !s .H.: et al. (1974) A Three
Generation Reproduction Study of AC 92,553 in Rats: Project
No. 72R—748. (Unpublished study received Sep 27, 1974 under
SF1556; prepared by Bio/dyflalfliCS, Inc., sutinitted by American
Cyananid Co., Princeton, N.J.; Q)L:094232-C)
00041897 American Cyanamici Co. (1975) General Summary—— prowl Herbicide
Residues in Soybean Plants, Seeds, Oil, Meal and Soil. SuT flary
of Studies 094648—B to ( 194648—3 and 094648—L through 094648-0.
(Unpublished study received Nod. 20, 1975 under 6Fl704
CDL: 09464R—A)
00041R98 Bouqhton, p.3.: Bohn, R.; Pondreau, R.E. (1975) prowl (CL 92,553):
The Gas ra’natOqraPhic Determination of CL 92553 N—(1—Ethyl—
pro l)_ 3 ,4_dimethY1_2,6i trobe e 1Th1r)e and CL 202,347 (4—
1-Ethyl propyl amino) -2-methyl -3,5-din itro—benzyl alcohol fran
Fortified Soybean Tissues (Foliacie, Green Seeds and Dry Seeds)
and Processed CciunoditieS (Oil and Meal): Retxrt No. C—539.l.
summary of studies 094648-C through 094648- J and 094648—L
through 094648-0. (Unpublished study received Nov 20, 1975 un-
der 6F1704; suLxnitted by American Cyanamid Co., Princeton, N.J.;
CDL: 094648B)
83
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00041901 Bouqhton, P.J. (1975) CL 92,553: Determination of N-.(l—Ethylpro—
pyl)-3,4-diiiiethyl—2,6 -djnjtrobenzen njne in Soybean Meal. ?4eth—
od M—604 dated Apr 24, 1975. (Unpublished study received Nov
20, 1975 under 6F1704; submitted by American Cyanamid Co.,
Princeton, N.J.; CDL:094648—F)
00041904 Boughton, P.J. (1974) CL 202,347: Determination of 4—(l—Ethylpro—
‘l)amino—2-methy1-3,5--dinitro benzyl alcohol in Soybean Green
Seed. Method M—561 dated Nov 12, 1974. (Unpublished study re-
ceived Nov 20, 1975 under 6F1704; submitted by American Cyanamid
Co., Princeton, N.J.; CDL:094648—I)
00046275 Zulalian, J. (1973) CL 92,553: Metabolism III. Isolation and Iden- .
tification of Metabolites Present in Urine, Feces, and Selected
Tissues of Rats Treated with Carbon—14 CL 92553 N—(1—Ethy].—
propyl)—2,6-dinitro-3,4-xylidine, Prowl Herbicide: Project
No. 2—463. (Unpublished study received Sep 27, 1974 under
SF1556; submitted by American Cyanamid Co., Princeton, N.J.;
CDL: 094475—B)
00046278 Gatterdam, P.F.; Fasinski, R.; Tondreau, R.E. (1973) CL 92,553:
Metabolism II. Uptake and Residues of Radioactivity in Cotton
following Incorporation of Carbon—14 CL 92,553 in Soil: Project
No. 2—464. (Unpublished study received Sep 27, 1974 under
5F1556; submitted by American Cyanamid Co., Princeton, N.J.;
CDL: 094475—E)
00046280 Ka oor, I.P.; Eisner, 5.1 <. (1974) CL 92,553: Metabolism v i i i. tip—
take and Residues of Radioactivity in Cotton Grown in Soil
Treated with Carbon- I A Labeled Prowl Herbicide: Project No. 2-
464. Final rept. (Unpublished study received Sep 27, 1974
under 5F1556 : submitted by American Cyanamid Co., Princeton,
N.J.; CDL:094475-G)
00046293 Kapoor, I.P.; Barringer, D.F., Jr.; Haugwitz, M.I.; et al. (1974)
Prowl Herbicide: Metabolism X. Isolation, Identification, and
Characterization of CL 92, 553 and Its Metabolites in Fish and
Its P uatic Environment: Project No. 2—463. (Unpublished study
received Sep 27, 1974 under 5F1556; prepared in cooperation with
Bionanics EG&G, Inc., submitted by American Cyanarnid Co.,
Princeton, N.J.; CDL:094674-G)
00046347 King, P.G.; Baker, R. (1980) Recaiunery3ed Method of Analysis.
Method M—855.3 dated Jun 16, 1980. (Unpublished study received
Sep 24, 1980 under 241—243; submitted by American Cyanamid Co.,
Princeton, N.J.; CDL:243330—A)
84
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00051958 Boughton, P.J. (1975) Prowl® (CL 92553: The Gas ( irc natoqraphic
Determination of CL 92553...and CL 202,347...frcsTi Fortified
Peanut Tissues (Foliage, Hay, Hulls and Nuts) and Processed CaTI—
ImDdities (Oil arid Meal): Rejort No. C-655. (Unpublished study
received Feb 9, 1976 under 6G1740: su nitted by American Cyanam—
id Co., Princeton, N.J.: CDL:095393-B)
00051959 Boughton, P.J. (1975) CL 92,553: Determination of N—(1—Ethylpro—
pyl)—3,4-dimethyl-2,6-dinitrObenzeflaflhifle in Peanut Oil. Method
M—590 dated Apr 2, 1975. (Unpublished study received Feb 9,
1976 under 6G1740; sutsnitted by American Cyanarnid Co., Prince-
ton, N.J.: CDL:095393—E)
00051960 Boughton, P. (1975) CL 92,553: Determination of N—(l—Ethylprc*7 11)—
3,4 -dij’nethyl-2,6-dinitrObeflZeflamifle in Peanut Meal. Method M—
592 dated Apr 2, 1975. (tjnpublished study received Feb 9, 1976
under 6G1740: sut nitted by American Cyananiid Co.., Princeton,
N.J.: CDL:095393—F)
00051961 Bouqhton, P.J. (1975) CL 202,347: Determination of 4—(1—Ethvlpro—
pyl)amino—2-methvl—3,5--diflitrO benzyl alcohol in P anut Foli—
aqe, Hay and Hulls. Method M—5F30 dated Feb 18, 1975. (Unpub-
lished study received Feb 9, 1976 under 6G1740: sut*nitted by
American Cyanamid Co., Princeton, N.J.: CDL:095393-H)
00051962 Boughton, P.J. (1975) CL 202,347: Determination of 4—(1—Ethylpro—
‘l )amino-2-TflethYl-3 , 5—dinitro-berizyl alcohol in Peanut Meal.
Method 14-593 dated Apr 2, 1975. (Unpublished study received Feb
C), 1976 under 6G1740: sutinitted by American Cyanamid Co.,
Princeton, N.J.: CDL:095393-J)
00051963 Boughton, P.J.: Kust, C.A.; Potts, C.R.: et al. (1975) Peanut Res-
idue Studies: Peixrt No. C-675. (Unpublished study including
re x)rt nos. C—670, C—674, C—672..., received Feb 9, 1976 under
6G1740: prepared in cooperation with North Carolina State Univ.,
Agricultural Experiment Station, Dept. of Crop Science, Peanut
Belt Pesearch , subidtted by American Cyanamid Co.,
Princeton, N.J.; CDL:095393—K)
85
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00051965 Marei, A.H.; Barringer, D.F., Jr.; Eisner, S.K. (1975) CL 92553:
Metabolism XVI: Residual Radioactivity in Peanut Seeds and Foli-
age Grown in Soil Treated with Carbon—14 Labeled Prowl Her-
bicide: Project ?‘ b. 2-460. (Unpublished study received Feb 9,
1976 under 6G1740; suhtiitted by American Cyanamid Co., Prince—
ton, N.J.: CT)L:095393—M)
00052558 Roughton, P.J. (1975) CL 92,553: Determination of N—(l—Ethylpro—
pyl)—3,4--dimethyl—2,6—dinitrobenzenarnjne in Lima Bean Foliage
and Pods. Method no. M—608 dated Jun 9, 1975. (Unpublished
study received Feb 9, 1976 under (cGl739; sufttitted by American
yanamid Co., Princeton, N.J.; CDL:095485-F)
00058478 Oliver, J.E. (1978) Letter sent to Files dated Mar 22, 1978:
Analysis of soybean’plant parts. (U.S. Agricultural Research
Service, Aqricultural Rnvironmental Quality Institute, Pesti-
cide Degradation Laboratory, unpublished study: CDL:233412—I)
00058657 Cueto, C., Jr.; Manus, A.G. (1979) Two—Year ‘tbxicity Study in Dogs:
AC 92,553: LBI Project I . 20755. Final rept. (Unpublished
study received Feb 26, 1981 under 241—243; prepared by Litton
Bionetics, Inc., sut nitted by American Cyanamid Co., Princeton,
N.J.; cDL:244444—A; 244445)
00058835 Devine, J.M. (1975) CL 92,553: Determination of N—(l—Ethylpropyl)—
3,4-dimethyl—2,6—dinitrobenzenainine in Fish Tissues (Wnole Fish,
Viscera, Fillet and Tail, and Gonads). Undated method M-632.
(Unpublished study received Jun 1, 1976 under 241—243; sutiiiitted
by American Cyanamid Co., Princeton, N.J.; CDL:224592—E)
00059738 LeBlanc, G.A. (1976) Acute Ikxicity of Prowl to Daphnia maqna.
(Unpublished study received 1976 under 241—243: prepared by Bio—
nanics, EG&G, sukinitted by American Cyanamid Co., Princeton,
N.J.; CDL:22839l—A)
00059739 Fink, R. (1976) Final Report: Acute Oral LDSO-—Mallard Duck: Prol—
ect . 130—110. (Unpublished study received 1976 under 241—
243; prepared by Truslow Farms, Inc., su nitted by American
Cyanamid Co., Princeton, N.J.; CDL:228391—B)
86
-------
00067283 American O ’anamid Canpany (1980) Summary of Residue Analysis for
Prowl Herbicide in Rice Grain. (Canpilation: unpublished study
received Aug 25, 1980 under 241—243: CDL:099565—A)
00067288 Haugwitz, M.I.; Eisner, S.K. (1974) Prowl Herbicide: Residual
Radioactivity in t 1 actatinq Coats Treated with 14C—CL 92553
N_(1_EthyiprOPyl)_3,4_ ethV1_2,inhtr0 emnme. PD-M
11:131—231. (rllnpuhlished study received Aug 25, 1980 under
241—243: submitted by American Cyanamid Co., Princeton, N.J.!
CDL: 099565—F)
00067289 Goidhamer, R.E. (1973) Metabolism of 14C—Ct 1 92553 Administered
in Capsules to Lactating Coats: Experiment Reference No. A—987:
PD—M 11:233—244. (Unpublished study received Aug 25, 1980 under
241—243; prepared by Bianetric Testing, Inc., submitted by Amer-
ican Cyanamid Co., Princeton, N.J.; CDL:099565G)
00067290 Tondreau, R.E. (1973) Prowl (CL 92,553): DeterminatiOn of CL 92553
Residues in Mil.k:
Report No. C—384. (UnpubliShed study received Aug 25, 1980 un-
der 241-243; submitted by American Cyanamid Co., Princeton,
N.J.; CDL:099565—H)
00067293 Marei, A.H.; Haugwitz, M.I.; Eisner, S.K. (1974) CL 92,553: Metabo-
lism: XII. Residual Radioactivity in Rice Grain and plants Grown
in Soil Treated with Carbon—14 CL 92,553: PD—M 11:376—416. Fi-
nal rept. (UnpubliShed study received Aug 25, 1980 under 241-
243; submitted by American Cyanamid Co., Princeton, N.J.; CDL:
099565—K)
00067519 Gustafsorl, R.H. (1976) Mutaqeflicity Tests of zpica1 Prowl
Herbicide and of Minor Ccinponent CL 4,269. (Unpublished study
received Jun 1 0, 1977: Jun 15, 1977 under 241—243: submitted by
American Cyanamid Co., Princeton, N.J.: CDL:230618—A)
00070962 American cyanamid Calipany (1976) Summary of Residue Analysis of
Prowl in Peas. Includes methods M—597.1 dated Dec 6, 1976:
M—693 dated Jul 20, 1976: M—742 dated Dec 6, 1976 and M—694
dated Jul 20, 1976. (CclTlpiiation: unpublished study received
Feb 8, 1977 under 241243; DLa:095797—A)
00071120 American Cyanamid CaTipany (1980) } sidues of Prowl Herbicide.
(CanpilatiOn: unpublished study received Jan 22, 1981 under 241—
243; CDL:099888C)
87
-------
00071121. Mangels, G.: Lucas, L. (1980) Prowl® Pendimethalin (CL 92553):
1 sidua1 Radioactivity in Rice Grain and Plants Treated 1 st-
emergence with Carbon—14 CL 92553 Prowl: PD—M 17—12:1—22.
Final rept. (Unpublished study received Jan 22, 1981 under 241—
243; sutmitted by American Cyanamid Co., Princeton, N.J.; CDL:
099888 —D)
00071123 Phcnipson, C.M.; Griffen, J., McAllister, W.A. (1980) Acute xicity
of AC 92,553 to the Freshwater Crayfish (Procambarus simulans):
Static Acute Bioassay Final Retort #25725. (Unpublished
study received Jan 22, 1981 under 241—243; prepared by
Analytical Bio th istry Laboratories, Inc., sulinitted by Artier—
ican Cyanamid Co., Princeton, N.J.; CDL:099889—B)
00071124 McAllister, W.A.; Thanpson, C.M.; Forbis, A.D.; et al. (1980) Resi-
due Accumulation Study in Crayfish (Procanbarus simulans)
with 14C-CL 92,553 (Pendimethaljn) under Static Conditions:
Final Residue Accumulation 1 port # 25687. (Unpublished study
received Jan 22, .1981 under 241—243; prepared by Analytical Bio
thetnistry Laboratories, Inc., sut uitted by American Cyanamid
Co., Princeton, N.J.; CDLa:099889-C)
0007.1129 Manuel, A.J. (1980) Recarinerided Method of Analysis: CL 99,900:
GC Method for the Determination of CL 99,900 Residues in Water.
Method M—1113 dated Dec 2, 1q80. (Unpublished study received
Jan 22, 1981 under 241—243; sut nitted by American Cyanamid Co.,
Princeton, N.J.: CDL:099889—J1)
00072802 American Cjanamid Ccinpany (1973) Toxicity Data: Prowl Herbicide,
¶I chnical: Report A—73—133. (Unpublished study received Sep
27, 1974 under 5F1556; CDL:094233—H)
00072810 Boughton, P.J. (1975) CL 202,347: Determination of 4—(1—Ethylpro—
v l )amino—2--methyl—3, 5-dinitro—benzyl alcohol in Soybean Meal.
Method M—605 dated Apr 24, 1975. (Unpublished study received
N v 20, 1975 under 6F1704; subnitted by American Cyanamid Co.,
Princeton, N.J.; CDL:094648—L)
00072822 Boughton, P.J. (1975) CL 92553: Determination of N—(1—Ethylpro--
pyl)— 3 , 4 -dimethyl—2,6-dinitrobenzena j in Peanuts. Method M—
577 dated Feb 18, 1975. (Unpublished study received Feb 9, 1976
under 6Gl740; subnitted by American Cyanainid Co., Princeton,
N.J.; CDL:095393—C)
00072823 Boughton, P.J. (1975) CL 92553: Determination of N—(l—Ethylpro—
pyl)- 3 , 4 —dimethyl—2,6-djnjtrobenzenamine in Peanut Fbliage, Hay
and Hulls. Method M—578 dated Feb 18, 1975. (Unpublished study
received Feb 9, 1976 under 6G1740; suthtitted by American Cyanam—
id Co., Princeton, N.J.; CDL:0953 3—D)
88
-------
00072824 Bouqhton, P.J. (1975) CL 202,347: Determination of 4—(1—Ethylpro—
pyl ) amino—2- -methyl —3, 5-d initro-benzyl alcohol in Peanuts.
Method M—579 dated Feb 18, 1975. (Unpublished study received
Feb 9, 1976 under 6Gl740; sutinitted by American Cyanamid Co,
Princeton, N.J.; CDL:095393—G)
00072825 Boughton, P. (1975) CL 202,347: Determination of 4 -(l—Ethy1pro—
pyl)amino-2—methyl—3,5-diflitto-beflZyl alcohol in Peanut Oil.
Method M—59l dated Apr 2, 1975. (Ur published study received Feb
9, 1976 under 6G1740; subiiitted by American Cyanamid Co.,
Princeton, N.J.; cDL:095393—I)
00073342 Deprospo, J.R. (1973) Acute Inhalation Study of AC 92553 in Rats:
Contract ? . 122—1968—43. Final rept. (Unpublished study
received Dec 21, 1973 under unknown admin. no., prepared by
Affiliated Medical Research, Inc., suI *nitted by American Cvan-
amid Co., Princeton, N.J.; CDL:130681—T-1)
00074621 Barringer, D.F., Jr.: Eisner, S. (1973) CL 92553: Metabolism
IV. Uptake and Residues of Radioactivity in Sweet Corn Crown in
Soil Treated with Carbon-14 Labeled Prowl Herbicide: PD-M
10:584—629. Final rept. (UnpubliShed study, including sut*nit—
ter st.mnary, received May 8, 1981 under 241—EX—98; sutinitted by
American Cyanamid Co., Princeton, N.J.; CDL:070070-D)
00093697 American Cyanainid Canpany (1981) Residues of Prowl. Includes un-
dated method M—458.1 : method M—465.l dated May 9, 1974: method
M—459.1 dated May 9, 1974; and others. (Canpilation; unpub—
lished study, including published data, received Jan 7, 1982
under 241—243; CDL:246583—A)
00093698 Mangels, C.: Lucas, L. (1981) Prowl Pendirnethalifl (CL 92553):
Residual Radioactivety in Corn Treated st nergence In-
corporated with Carbon- I A CL 92553 Prowl Herbicide: PD-M 18-6:
1-21. Final rept. (Unpublished study received Jan 7, 1982
under 241—243; sutinitted by American Cyanamid Co., Princeton,
N.J.; CDL: 246583—B)
00099890 Atkins, B.; Greywood—Hale, E.; Macdonald, R.; et al. (1974) Effect
of pesticides on Apiculture: Project . 1499. 1974 annual
rept. (Unpublished study received Jul 31, 1978 under 148—1259;
prepared by Univ. of California-—Riverside, Citrus pesearch
Center and Agricultural Experiment Station, Dept. of Entomoloqy,
subi itted by Tha çson-Hayward themical Co., Kansas City, KS;
CDL: 2345l1—S)
89
-------
00100504 Graney, R.L. (1981) The U-ironic (21 Day) Toxicity of AC 92,553 to
Daphnia magna Straus: Project Na. 5179. (Unpublished study
received ? pr 20, 1982 under 241—243; prepared by Biospherics,
Inc., sut nitted by American Cyanamid Co., Princeton, N.J.; CDL:
247299—A)
00106751 American Cyanamid Co. (1974) The Name, th Ttical Identity and Can—
psition of Prowl Herbicide. (Canpilation; unpublished study
teceived on unknown date under 5Gl5 7; CDL:094283—A)
00106752 American Cyanamid Co. (1974) Extent of Prowl Herbicide and Its
Metabolite Residues--Cotton Plants, Seed, Oil, Meal and in
Milk, Including a Description of the Analytical Methods used.
(Canpilation; unpublished study received on unknown date under
5G1567; DL:094284—A)
00106764 Sleiqht, B. (1973) Acute Toxicity of AC—92553 to Bluegill. (Lepanjs
macrochirus), Rainbow Trout (Salmo gairdneri) and thannel Cat—
Fish (Ictaluras punctatus). (Unpublished study received on
unknown date under 5G1567: prepared by Bioncinics, Inc., sub-
mitted by American Cyanamid Co., Princeton, NJ; CDL:094287-E)
00106777 American Cyanamid Co. (1974) Introduction to Environmental them—
istry Studies with Prowl (AC 92,553). (Canpilation; unpublished
study received on unknown date under 5G1567; CDL:094279—A;
094280; 094281; 094282)
00106779 American Cyanamid Co. (1974) Analyses for Residues of Prowl in
Sweet Corn and Other Crops. (Ccinpiiation; unpublished study
received Sep 27, 1974 under 5F1556; CDL:094470—A)
00106785 American Cyanamid Co. (1975) Extent of Prowl Herbicide and Its
Metabolite Residues in Peanut Foliage, Hulls, Nuts, Oil and
Meal, Including a Description of the Analytical Methods Used.
(Canpilation; unpublished study received Feb 9, 1976 under
6Fl74l; CDL:094960—A)
00106791 American Cyanamid Co. (1976) Residues of Prowl Herbicide in
Sorqhum. (Canpilation: unpublished study received Jan 6, 1978
under 241—EX—88; CDL:096712—A)
00106795 Zulalian, J.; Adams, C.; Eisner, S.; et al. (197R) CL 92553: Re-
sidual Radioactivity in Potato Thbers Grown under Greenhouse and
Field Conditions in Soil Treated with Carbon-l4 and a Mixture
of Carbon—13 and Carbon-l4 Labeled Prowl Herbicide: PD-M
15—17:1—26. (Unpublished study received Oct 5, 1978 under 241—
243; sut nitted by American Cyanamid Co •, Princeton, NJ; CDL:
097432—C)
00106797 American Cyanamid Co. (1978) Amounts of Residues of Prowl, Its
Metabolite (CL 202,347) Metribuzin (Sencor or Lexone) and Eptani
in or on Potatoes. (Canpilation; unpublished study received
Oct 5, 1978 under 241—243; CDL:097433—A; 097434)
90
-------
00106807 American Cyanamid Co. (1979) Residue Analysis of Prowl or Atrazine
in Grain Sorghum. (Canpilation: unpublished study received Aug
14, 1979 under 241—243, CDL:098918—A)
00106808 American Cyanamid Co. (1979) Residues of Prowl Herbicide. (Canpi—
lation; unpublished study received SeD 21, 1979 under 241—EX—95;
CDL : 098994—A)
00106820 American C ranamid Co. (1978) Amounts of Residues of Prowl, Its
Metabolite (CL 202,347) Atrazine, and Bladex in or on Field
Corn. (Ccznpilation: unpublished study received May 11, 1978
under 241—243 , CDL:233898—A)
00106829 American Cyanamid Co. (1978) Residues of Prowl Herbicide. (Canpi—
lation; unpublished study received Aug 14, 1979 under 241—243;
CDL: 238944—B: 241020)
00106830 American Qyanamid Co. (1975) Analyses for Residues of Prowl
Herbicide in ieat and Other Crc*s. (Canpilation; unpublished
study received Oct 29, 1979 under 241—243; CDL:241256—A)
00108317 Barringer, D.; Eisner, S. (1975) CL 92553: Metabolism X I V. Uptake
and Residues of Radioactivity in Winter lneat Grown in Soil
Treated with Carbon-14 Labeled Prowl Herbicide: PD-M 12: 402-
433. Progress rept., v 5, 1973 to Jan 7, 1975. (Unpublished
study received Sep 21, 1979 under 241-EX—95; su}:initted } r
American Cyanamid Co., Princeton, NJ; CDL: 098994-B)
00109915 Marei, A.; Barrinqer, D.; Eisner, S. (1975) CL 92,553: Metabolism
XVI: Residual Radioactivity in Peanut Seeds and Foliage Grown
in Soil Treated with Carbon-14 Labeled Prowl Herbicide: PD—M
12:1365—1387. (Unpublished study received Feb 9, 1976 under
6F174l; sutn ritted by American Cyanamid Co., Princeton, 3;
CDL: 094960—B)
0011.4313 American Cyanamid Co. (1982) Residues of Prowl. (Canpilation:
unpublished study received Sep 14, 1982 under 241—243: CDL:
248325—A)
00117444 Wolfe, G.; Mistretta, L.; Durloo, R. (1982) Teratology Study in
Rabbits: AC 92553 Technical: Project 1 . 362—164. Final rept.
(Unpublished study received Oct 28, 1982 under 241—243: prepared
by Hazieton Laboratories America, Inc., sut*nitted by American
Oyanamid Co., Princeton, J; CDL:248659—A)
00129937 American Cyanamid Co. (1983) Residues of Prowl Herbicide. (Canpi-
lation; unpublished study received Jul 27, 1983 under 241—243:
CDL: 250807—A)
91
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00131772 Ward, G. (1.983) Acute Toxicity of AC 92,553 Technical and Formulat-
ed to 1 ribryos-larvae of Eastern () ‘sters ...: Report No. BP—83—
6—65; Prolect No. R95. (Unpublished study received Oct 28, 1983
under 241—1243; prepared by HG & G Bionai ics, submitted by
American Cyanamid Co., Princeton, NJ; CDL:251601—A)
00131773 LeBI.anc, G., Sousa, J. (1983) Acute Toxicity of AC 92,553 to than—
nel Catfish ...: Report #BW—83--2--1361. (Unpublished study re-
ceived Oct 28, 1983 under 241—243: prepared by HG & G Bioncinics,
submitted by American Cyanamid Co.., Princeton, NJ; CDL:251601-C)
00131774 Ward, G.; Shuba, p. (1983) Acute Toxicity of AC 92,553 Technical
and Formulation to Sheepshead Minn s ...: Report No. BP—83-3—
39; Project No. R95. (Unpublished study received Oct 28, 1983
under 241—243; prepared by HG & G Bionc*nics, submitted by Ameri-
can Cyanamid Co., Princeton, NJ; CDL:251601-E)
00131775 Ward, G.; Shuba, P. (1983) Acute Toxicity of AC 92,553 Technical
and Formulation to Pink Shrimp ...: Report No. BP—83—1-5; Pro—
lect No. R95. (Unpublished study received Oct 28, 1983 under
241-243; prepared by HG & G Rioncinics, submitted by American Cy—
anamid Co., Princeton, NJ; CDL:251601-G)
00134355 American Cyanamid Co. (1980) Residues of Prowl Herbicide. (Cc i i i—
pilation; unpublished study received Jun 11, 1980 under 241—
243; DL:242640—A)
GS0187—001 American cyanamid Co. (1974) Data Sheet for 90% Technical Pendi—
methalin. In US EPA Registration Jacket for Product 241—245.
GSO187—002 Zulalian, J. Lucas, L.: Tondreau, R. (1980) CT, 92553: Isolation
and Identification of Malor Metabolites Found in Peanut Hulls
fraii Peanut Plants Grown under Greenhouse and Field Conditions
in Soil Treated with C-14 and a Mixture of C-13 and C-l4
Labeled PRCWL Herbicide. (Unpublished study labeled Report
No. PD—MI Vol. 16—30; received Apr 20, 1980, under 241—243;
submitted by American Qjanamid Co., Princeton, N.J.;
QDL: 099395—H)
92
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0MB Approval No. 2000-0468 Appendix 11-3
FIFRA SECTION 3(C)(2)(B) SUMMARY SHEET
EPA REGISTRATION NO.
PRODUCT NAME
APPLICANT’S NAME
DATE GUIDANCE DOCUMENT ISSUED
With respect to the requirement to submit “generic” data imposed by the FIFRA section 3(C}(2)(B) notice contained in the referenced
Guidance Document, I am responding in the following manner:
1. I will submit data in a timely manner to satisfy the following requirements. If the test procedures I will use deviate from (or are not
specified in) the Registration Guidelines or the Protocols contained in the Reports of Expert Groups to the Chemicals Group, OECD
Chemicals Testing Programme, I enclose the protocols that I will use:
E 2. I have entered into an agreement with one or more other registrants under FIFRA section 3(C)(2)(B)(ii) to satisfy the following data
requirements. The tests, nd any required protocols, will be submitted to EPA by:
NAME OF OTHER REGISTRANT
E 3. I enclose a completed “Certification of Attempt to Enter Into an Agreement with Other Registrants for Development of Oats” with
rasp.ct to the following date r.quiremenw
4. I request that you emend my registration by deleting the following uses (this option Is not available to applicants for new products):
D 5. I request voluntary cancellation of the registration of this product (ThIs option is not available to applicants for new products.)
REGISTRANT’S AUTHORIZED REPRESENTATIVE SIGNATURE DATE
EPA Poem 86801 (1082 1
-------
OMBADOrovSINO. 2 , P endix 11-4
8 (Exoires: 12-31-83)
CERTIFICATION OF ATTEMPT TO ENTER
INTO AN AGREEMENT WITH OTHER REGISTRANTS
(To qualify, c tify four items) FOR DEVELOPMENT OF DATA
1. I am duly authorized to represent the following firm(s) who are subject to the require-
ments of a Notice under FIFRA Section 3(c)(2XB) contained in a Guidance Document
to submit data Concerning the active ingredient:
GUIDANCE DOCUMENT DATE
ACTIVE INGREDIENT
NAME OF FIRM
EPA COMPANY NUMBER
fThis firm or group of firms is referred to below as “my firm”.)
2. My firm is willing to develop and submit the data as required by that Notice, if necessary. However, my firm would prefer to enter
into an agreement with one or more other registrants to develop jointly, or to share in the cost of developing, the following required
items or data:
3. My firm has offered in writing to enter Into auth an ugm.m.nt. Copies of the offers are attached. That offer was Irrevocable and Included an offer to be
bound by an arbitration decision under FIFRA Section 3(c)(2)(B)(Iii) If final agreement on all terms could not be reached otherwies. This offer mad.
to the following firm(s) on the following date(s):
NAMEOFFIRM DATEOFOFFER
iTowever , none of those firm(s) acceoted my offer .
4. My firm requests that EPA not suspend the registration(s) of my firm’s product(s), if any of the firms named in paragraph (3) abà
have agreed to submit the data listed In paragraph (2) above In accordanc, with the Notice. I understand EPA will promptly Inform
me whether my firm must ejbmit data to avoid suspension of Its registration(s) under FIFRA Section 3(c)(2)(B). (This statement
does not apply to applicants for new products.) I give EPA permission to disclose this statement upon request.
TYPED NAME SIGNATURE OATS
-------
Appendix ITT — I
P} DDUCP SPECIFIC DATA REPORT’
EPA Registration r D. ____ ____( uidance T cument for —
Date
I ]‘rest noti I
with I
I lreaui.redlI am xmplyina
requirements b rj
I for my Idata
Iproduct 1 Su xnit—I
listed I tinq I
Data I (For EPA
Use C ily)
I labove I
Accession
Numbers
Reqistration I (check I
MRID#
(At—
tached)IASSigfled
Guideline No.1 Name of Pest Ibelow)
l58.20 I I
‘Citing
1
I
I
PR XX1CT I I
cHEMISTRY I — I
61—i I Identity of I 1
-------
Ar’pendjx TTT—i (continued)
I Test not.I
I required II am (x plyina with I
for my Idata requirements byl
I Ipr(xluct I ISubmif I
I Ilisted I Itinq I
I above I Data I (Por EPA Use ily)
Registration I I(check (At-- Accession imbers
Guideline No. Name of Test below) lOiting MRID#
63—13
63—14
Stability
idizinq/reducjnq
reaction
I
I
tached)
Assiqned
63—15
F larrunabi ljty
63—16
63—17
63—18
Exp1 ability I
Storaqe stability
Viscosity 1
I I
1 1
63—19
Miscibility
63—20 1
corrosion
characteristics
I
I
f
63—21 Dielectric break— I I I
I_down_voltage I
I
I
15R.135 I I
TOxIcoLoGy I I I
I
I
81—1 I Acute oral LT)—50, I
frat I
I
I
81—2
I Acute dermal I I
JP— ° I
I
81—3
Acute inhalation, I I
LC—5Orat I I
I
I
I
81-4
Primary eye I I I
irritation, rabbit I I I
I
81—5 1 Primary dermal. I I I
I irritation I I I I
81—6 I Dermal sensitiza— J I I I
Ition I I I I
-------
Chopt.r l—Environrnent& Protection Agency
ca t obtained the data from anoth
fi (identify): applicant copied da
ftc a publication: applicant obtai d
a Co y of the data from EPA).
(d The applicant shall submit ith
his a plication a statement that A.
in its valuation of the properties effi-
cacy. d safety of the form ated
end-us product. may not consid r any
data supporting the appi ation,
except t e following data:
(1) Th data the applicant as sub.
mitted to EPA under paragra h (b) of
this seetlo
(2) 0th data pertain to the
safety of t e product’s act e ingredi-
ents. rathe than to the s ety of the
end-use pro Ct; arid
(3) Exlstin tolerances. ad additive
regulations. xemptiofls and other
clearances Lss ed u.nde the Federal
Food. Drug, an Cosme Act.
(e) If the ap Icant ows that any
item of data he subm ted under this
section was gene ted y i or at the ex-
pense of) anothe pe n who original-
ly submitted the a a to EPA (or Its
predecessor. tJSD ) on or after Janu-
ary 1, 1970. to sup ort an application
for registration, xperlmefltal: use
permit . or amen nt adding a new
use to an existin r tration. or for
reregistration ( the applicant
and the origin data submitter have
reached writte agr ment on the
amount and t terms f payment of
any cornpe Ion the. may be pay-
able und section
3(CX1XDX1I) Ith regar to approval
of the appil tion). the a licant shall
submit to A a statem nt that he
has furnis d to each suc identified
original d submttter
(1) A n if Ication of the ppllcant’S
intent to pply for registrati * includ-
ing the oposed product
(2) offer to pay the pe n corn-
pensati n. with regard to the provs.l
of the application, to the cx nt re-
quire by F’IPRA sections 3(c (l.XD)
snd3 )(2)(D);
(3) An Identification of the I rn(s)
of to which the offer applies,
An offer to commence neg tie.-
tin to ascertain the amount d
te of compensation to be paid; d
5) The applicant’s name. addr
d telephone number.
§ 162. 0
If the applicant’s product on-
tai any active ingredient other han
thos that are present solely b ause
of th incorporation into the p duct.
during formulation, of one more
other gistered pesticide roducts
purcha.s from another roducer.
then the pplicant shall a o comply
with 1 162. -5 as to such tive ingre-
dient, and he applicatlo shall con-
tain an ac wiedgrnent hat for pur-
poses of F l A section (c)( 1 )(D) the
application re es on ( d any result-
ing registration shoul be regarded as
If it were based th Administrator’s
consideration of) h following data:
(1) All data sub ted or specifically
cited by the appi nt in support of
the registration;
(2) Each othe ite of data In the
Agency’s files w ich:
(1) Concerns e prop ties or effects
of any such lye Ingre ent; and
UI) Is one f the types of data that
EPA would equire to be s binitted for
scientific view by EPA I the appli-
cant sou t the Initial r tratlon
under Section 3(c 5) of a
produc with composition an intend-
ed us identical to those pro d. for
the plicant’s product, und the
data requirements in effect o the
dat EPA approves the sppli t’s
pr ent application.
3,6.afld25OfFIFRA.U&Ulefld 7
.S.C, 136 et seq,)
44 FR 21953. MaY Li. 1919 )
• 162.10 Labeling requIrements
(a) General—U) Contents of the
labeL Every pesticide products shall
bear a label containing the informa-
tion specified by the Act and the regu-
lations In this Part. The contents of a
label must show. clearly and promi-
nently the following:
(i) The name, brand, or trademark
under which the product Is sold as pre-
scribed in paragraph (b) of this
section;
UI) The name and address of the
producer. registrant. or person for
whom produced as prescribed in para-
graph (C) of this section,
(ill) The net contents as prescribed
in paragraph Cd) of this section;
-------
§ 162.10
Title 40—Protection of Environment
(iv) The product registration
number as prescribed in paragraph (e)
of this section;
(v) The producing establishment
number as prescribed in paragraph (f)
of this section:
(vi) An ingredient statement as pre-
scribed In paragraph (g of this
section:
(vii) Wax-zung or precautionary state-
znent.s as prescribed in paragraph ( Ii)
of this section;
(viii) The dire tjo s for use as pre-
scribed l x i paragraph U) of this section;
and
(l x) The use classification(s) as pre-
scribed in paragraph ( .j) of this section.
(2) Promznence and egtbilzty. (I) All
worth, statements, graphic representa-
tions, designs or other information re-
quired on the labeling by the Act or
the regulations In this part must be
clearly legible to a person with normal
vision, and must be placed with such
conspicuousness (as compared with
other words, statement.s, designs, or
graphic matter on the labeling) and
expressed In such terms as to render it
likely to be read and understood by
the ordinary individual under custom-
ary conditions of purchase and use.
(U) All required label text must:
(A) Be set in 6-point or larger .type;
(B) Appear on a clear contrasting
background; and
(C) Not be obscured or crowded.
(3) Language to be used. All required
label or labeling text shall appear. in
the English language. However, the
Agency may require or the applicant
may propose additional text In other
languages as Is considered necessary to
protect the public. When additional
text In another language is necessary,
all labeling requirement., will be ap-
plied equally to both the English and
other-language versions of the label.
Ing.
(4) PLacement of Label—U) GeneraL
The label shall appear on or be secure-
ly attached to the Immediate contain.
Cr of the pesticide product. For put.
poses of this Section. and the mis-
branding provisions of the Act, ‘se.
cutely attached” shall mean that a
label can reasonably be expected to
remain affixed during the foreseeable
condltlo s and period of use. I L the un-
mediate container Is enclosed within a
wrapper or outside container through
which the label cannot be clearly read.
the label must also be securely at-
tached to such outside wrapper or con-
tairler, if it is a part of the package as
customarily distributed or sold.
(ii) Tank cars and other bulk con-
ta ners—(A) Transportation. While a
pesticide product is in transit, the ap-
propriate provisions of 49 CFR Parts
170-189, concerning the transportation
of hazardous material.s, and specifical-
ly those provisions concerning the la-
beling, marking and placardj .ng of haz-
ardous materials and the vehicles caz--
rying them, define the basic Federal
requirements. In addition, when any
registered pesticide product f trans-
ported in a tank car, tank truck or
other mobile or portable bulk contain-
er, a copy of the accepted label must
be attached to the shipping papers.
and left with the consignee at the time
of delivery.
(B) Storage. When pesticide prod-
ucts are stored in bulk containers,
whether mobile or stationary, which
remain in the custody of the user, a
copy of the label of labeling, including
all appropriate directions for use, shall
be securely attached to the container
In the iznzxiedjatë vicinity of the dis-
charge control valve.
(5) FaLse or misleading statementL
Pursuant to section 2(q)(lXA) of the
Act, a pesticide or a device declared
subject to the Act pursuant to
* 162.15, Is misbranded If Its labeling Is
false or misleading In any particular
including both pesticidal and non-pes-
ticidal claims. Examples of statement.j
or representations In the labeling
which con. t1tut.e misbranding include:
(I) A faIs or misleading statement
concerning the composition of the
product;
• (11) A false or misleading statement
concerning the effectiveness of the
product as a. pesticide or device;
(Ill) A false or misleading statement
about the value of the product for
purposes other than as a pesticide or
device;
(lv) A false or misleading comparison
with other pesticides or devices;
(v) Any statement directly or indi-
rectly Implying that the pesticide or
device Is recommended or endorsed by
-------
Chapter I—Environmental Protection Agency
§ 162.10
any agency of the Federal Govern-
ment;
(vi) The name of a pesticide which
contains two or more principal active
ingredients if the name suggests one
or more but not all such prrncipai
active ingredients even though the
names of the other ingredients are
stated elsewhere in the labeling;
(vii) A true statement used in such a
way as to give a false or misleading im-
pression to the purchaser;
(viii) Label disclaimers which negate
or detract from labeling statement.S re-
quired under the Act and these reguia-
tions;
(ix) Claims as to the safety of the
pesticide or Its ingredients . including
statements such as “safe,” “nonpoison-
ous.” “noniniurioUs.” “harmless” or
“nontoxic to humans and pets” with
or without such a qualUylng phrase as
“when used as directed”: and
(x) Non-numerical and/or compara-
tive statements on the safety of the
product, Including but not limited to:
(A) “Contains all natural ingredi-
ents ”;
(3) “Among the least toxic chemi-
cals known’
(C) “Pollution approved”
(6) 7 1 no.1 printed ZabelinQ (I) Except
as provided In paragraph (a)(6)(il) of
this section, final printed labeling
must be submitted and accepted prior
to registration. Eowever, final printed
labeling need not be submitted until
draft label texts have been provision-
ally accepted by the Agency.
(I I) Clearly legible reproductions or
photo reductions will be accepted for
unusual labels such as those silk-
screened directly onto glass or metal
containers or large bag or drum labels.
Such reproductions must be of micro.
film reproductiOn quality.
(b) Name brand, or trademark. (1)
The name, brand, or trademark under
which the pesticide product is sold
shall appear on the front panel of the
label.
(2) No name, brand, or trademark
may appear on the label which:
(I) Is false or misleading, or
(11) Ras not been approved by the
Administrator through registration or
supplemental registration as an addi-
tional name pursuant to 162.6(b)(4).
(C) Name and address of producer.
registrant. or person for whom pro-
duced. An unqualified name and ad-
dress given on the label shall be con-
sidered as the name and address of the
producer. If the registrant’s name ap-
pears on the label and the registrant is
not the producer, or if the name of the
person for whom the pesticide was
produced appears on the label, it must
be qualified by appropriate wording
such as Packed for ‘ ,“ “Distribut-
ed by • , or “Sold by “toshow
that the name Is not chat of the pro-
ducer.
Cd) Net weight or mea. ure of con-
tent. . U) The net weight or measure
of content shall be exclusive of wrap-
pers or other materials and shall be
the average content unless explicitly
stated as a minimum quantity.
(2) If the pesticide Is a liquid, the
net content statement shall be In
terms of liquid measure at 68 F (20 ’C)
and shall be expressed in conventional
American units of fluid ounces, pints,
quarts, and gallons.
(3) If the pesticide is solid or semiso.
lid, viscous or pressurized, or Is a mix-
ture of liquid and solid, the net con-
tent statement shall be In terms of
weight expressed as avoirdupois
pounds and ounces.
(4) In all cases, net content shall be
stated in terms of the largest suitable
units, i.e.. “1 pound 10 ounces” rather
than “26 ounces.”
(5) In addition to the required units
specified, net content may be ex-
pressed in metric units.
(6) Variation above minimum con-
tent or around an average is permls’i-
ble only to the extent that It repre-
sents deviatl,on unavoidable in good
manufacturing practice. Variation
below a stated minimum Is not permit-
ted. In no case shall the average con-
tent of the packages in a shipment fall
below the stated average content.
(e) Product registration number.
The registration number assigned to
the pesticide product at the time of
registration shall appear on the label,
preceded by the phrase “EPA Regis.
tration No..” or the phrase “EPA Reg.
No.” The registration number shall be
set in type of a size and style similar to
other print on that part of the label
on which It appears and shall run par-
-------
§ 162.10
IDle 4 O—Protectjon of Environment
allel to it. The registratjo number
and the required identifying phrase
shall not appear in such a manner as
to suggest or imply recommendation
or endorsement of the product by the
Agency.
(I) Producing establishments regzs-
tration number. The producing estab-
lLshinent registration number preced-
ed by the phrase “EPA E .st.”, of the
final establishment acwhich the prod-
uct was produced may appear in any
suitable location on the label or imme-
diate container. It must appear on the
wrapper or outside container of the
package if the EPA establishment reg-
istration number on the immediate
container cannot be clearly read
through such wrapper or container.
(g) Ingredient statement—(1) Gener-
aL The label of each pesticide product
must bear a statement whjch contains
the name and percentage by weight of
each active Ingredient, the total per-
centage by weight of all inert ingrecij.
ents; and If the pesticide conta ar-
senic In any form, a statement of the
percentages of total and water-soluble
arsenic calculated as elemental ar-
senic. The active ingredien Imast be
designated by the term “active Ingredi-
ents” and the Inert Ingredients by the
term ‘inert ingredients,” or the singu.
lax forms of these terms when appro-
priate. Both terms shall be In the
same type size, be aligned to the same
margin and be equally prominent. The
statement “Inert 1ngredien , none” is
not required for pesticides which con-
tain 100 percent active 1ngredIen .
t nless the Ingredient statement Is a
complete analysis of the pesticide, the
term “analysis” shall not be used as a
heading for the Ingredient statement.
(2) Position of ingredient statenzent.
(I) The Ingredient statement Is nor-
mally required on the front panel of
the label. If there Is an outside con-
tainer or wrapper through which the
ingredient statement cannot be clearly
read, the ingredient statement must
also appear on such outside container
or wrapper. If the size or form of the
package makes It Impracticable to
place the Ingredient statement on the
front panel of the label. permission
may be granted for the ingredient
statement to appear elsewhere.
(ii) The text of the ingredient state-
ment must run parallel with other
text on the panel on which It appears,
and must be clearly distinguishable
from and must not be placed in the
body of other text.
(3) Names to be used in ingredient
statemei t. The name used for each in-
gredient shall be the accepted
corrunon name, if there Is one, fol-
lowed by the chemical name. The
common name may be used alone only
if It. is well known. If no common name
has been established, the chemical
name alone shall be used. In no case
will the use of a trademark or propri-
etary name be permitted unless such
name has been accepted as a common
name by the Administrator under the
authority of Section 25(c)(6).
(4) Statemen of percentages The
percentages of Ingredients shall be
stated in terms of weight-to.weight.
The sum of percentages of the active
and the inert lngredien shall be 100.
Percentages shall not be expressed by
a range of values such as “22-25%.” I I
the uses of the pesticide product are
expressed as weight of active ingredi-
ent per unit area, a statement of the
weight of active ingredient per unit
volume of the pesticide formulation
shall also appear in the Ingredjen
statement.
(5) Accurac , of stated percentages,
The percentages given shall be as pre-
cise as possible reflecting good manu-
facturing practice. II there may be un-
avoidable variation between manufac-
turing batches, the value stated for
each active Ingredient shall be the
lowest percentage which may be
present.
(6) DeterioratIon, Pesticides which
change In chemical composition sig-
nificantly must meet the following la-
beling requlremen :
1 In cases where It is determined
that a pestIcide formulation changes
chemical composition significantly,
the product must bear the following
statement In a prominent position on
the label: “Not for sale or use after
(date).”
(II) The Product must meet all label
claims up to the expiration time Indi-
cated on the label.
(7) Inert ingredjent& The Adrnlnjs-
trator may require the name of any
-------
Chapter I—Environmental Protection Agency
§ 162.10
Inert Ingredient(s) to be listed in the
ingredient statement if he determines
that such Ingredient(s) may pose a
hazard to man or the environment.
(h) WarruiWS and precaut .wnarY
stalement .s. Required warnings and
precautionary statements concerning
the general a.rea.s of toxicological
hazard including hazard to children.
environmental hazard. and physical or
chemical hazard fall into two groups;
those required on the front panel of
the labeling and those which may
(I) Human hazard signal word—(A)
Toxicity Category L All pesticide prod.
ucts meeting the criteria of ToXicity
Category I shall bear on the front
panel the signal word “Danger.” In ad-
dition if the prodUCt was a.sslgned to
Toxicity Category I on the basis of Its
oral, inhalation or dermal toxicity (as
distinct from skin and eye local ef-
fects) the word “Poison” shall appear
in red on a background of distinctly
contrasting color and the skull and
crossbones shall appear in Immediate
proximitY to the word “poison.”
(B) Toxicity Category II. All pesti-
cide prodUCt.’ meeting the criteria of
Toxicity Category II shall bear on the
front panel the signal word “Warn-
ing.”
(C) TOXICUY Category ilL All pesti-
cide product.’ meeting the criteria of
Toxicity Category Ifl shall bear on
the front panel the signal word “Cau-
tion.”
CD) TOxicity Category IV. All pesti-
cide products meeting the criteria of
Toxicity Category IV shall bear on the
front panel the signal word ‘Caution.”
CE) Use of signal words. t7se of any
signal word(s) associated with a higher
appear elsewhere. Specific require-
ments concerning content, placement,
type size, and prominence are given
below.
Cl) Required front panel statements.
With the exception of the child
hazard warning statement, the text re-
quired on the front panel of the label
Is determined by the Toxicity Catego-
ry of the pesticide. The category is as-
signed on the basis of the highest
hazard shown by any of the indicators
in the table below:
Toxicity Category is not permitted
except when the Agency determines
that such labeling Is necessary to pie-
vent unreasonable adverse effects on
man or the environment. In no case
shall more than one hllrn2n hazard
signal word appear on the front panel
of a label.
(ii) Child hazard warning. Every pes-
ticide product label shall bear on the
front panel the statement “keep out of
reach of children.” Only in cases
where the likelIhood of contact with
children during distribution, market-
ing. storage or use Is demonstrated by
the applicant ,.to be extremely remote.
or If the nature of the pesticide Is such
that it is approved for use on Infants
or small children. may the Administra-
tor waive this requirement.
(iii) Statement of practical treat-
ment—(A) Toxicity Category I. A
statement of practical treatment (first
aid or other) shall appear on the front
panel of the label of all pesticides fall-
ing Into Toxicity Category I on the
basis of oral, inhalation or dermal tox-
icity. The Agency may, however,
permit reasonable variations In the
Haz in cat0f$ r
I I It III iv
Or.t LO.. ._—. UP to n ic dmg 50
mg/kg.
,a on LC......... Lip to and nciucsng .2
mg .
From 50 thru 500 mgikg.. From 500 ttma 5000 mg /
‘ p.
From .2 wv 2 mg/IiIur ... From 2. thr,. C rng/ttw,..
Gmmtur thin 5000 mg /
Q
Gtsatr than 20 mqitt.r.
Qsmi L0,.... ......
Up to and includIng 200
mg/kg.
From 200 thvu 2000.._. From 2.000 thiu 20.000
.
Gsawv than 20.000.
5,, .tfsdIs._ .....—
Ccivas.vS com.al
p ty not ruvirilOtS
w wi 1
Corn.sI Opacity No com.at cIty
r,yrsibls * tIW% 7 wntatjOn r.’ .riibli.
days. ,Vlt*bOfl wtU*t 7 days.
p.r En9 1O 7 data.
SS ’ irS Wfltitlat St 72 MOdSfitS WvTtadQn ii 12
No r oon.
PMd aighi Vntokofl at
SMi iffiCli....—..
t 0Ifl . P Ious. —
l2P to uvs.
-------
§ 162.10
placement of the statement of practi-
cal treatment is some reference such
as “See statement of practical treat-
ment on back panel” appears on the
front panel near the word “Poison”
and the skull and crossbones.
(B) Other to ricity ca egoi-ies. The
statement of practical treatment is not
required on the front panel except as
described In paragraph (h)(1)(iii)iA) of
this section. The applicant may, how
ever, include such a front panel state-
ment at his option, Statements of
practical treatment are, however, re-
quIred elsewhere on the label in
accord with paragraph (h)(2) of this
section if they do not appear on the
front panel.
(iv) Placement and prominence, All
the require front pa.nel warning state-
ments shall be grouped together on
the label, and shall appear with suffi-
cient prominence relative to other
front panel text and graphic material
to make them unlikely to be over-
looked under customary conditions of
purchase and use. The following table
shows the minimum type size require-
ment ,s for the front panel warning
statements on various sizes of labels:
(II) Environmental hazards. Where a
baaard exists to non target organism.s
excluding humans and domestic ani-
111ft14 , precautionary statements are re-
quired stating the nature of the
:
S,z. at abi front oan.I fl sauar .
fiChis
Poin ts
n.gulr.d x out
$ 9naS
wO . 3 11 c ” r
cao.tals
Sanduncor
AbOV.51010
Abov , 10 1o15 ..
—
Ov o r3O *...—.-
6
10:
121
14
t IP
6
1
8
¶0
12
(2) Other required warnings and pr-
mutionarg statements, The warnings
and precautionary statements as re-
quired below shall appear together on
the label under the general heading
“Precautionary Statements” and
under appropriate subheadings of
“Hazard to Humans and Domestic AriA-
rnals,” “Erwjronxnentaj Hazard” and
“Physical or Chemical Hazard:’
(1) Hazard to human,! and domestic
animals. (A) Where a hazard exists to
humans or domestic animals, precau-
tionary statements are required 1.ndi.
cating the particular hazard, the
route(s) of exposure and the precau-
tions to be taken to avoid accident,
injury or damage. The precautionary
paragraph shall be Inunedlately pre
ceded by the appropriate hazard signal
word,
(B) The following table depicts typi-
cal precautionary statements. These
statements must be modified or ex-
panded to reflect specific hazards.
hazard and the appropriate, precau-
tions to avoid potential accident,
injury or damage. Examples of the
hazard statements and the clrcum-
Title 40—Protection of Environment
Tci ty
PutiOnaiY $tata 11Sflh$ by totaoty cat.gory
Orui, h’Wtuiation, or dsrvnhi toacfty
S iXt ay. locid ifficts
I
Find (poisonous) if awuifowud (ivYiaa.d or abSc4tSd
ifWougIt ads]. Oo not brs.ifw vapor C at or spray
tnot). Do not get wt eyes, on utun, or on cloltisig
(Ftons panel sfat.nsv* of acXL tz..ansnt i.’
QINS J.
Ccvroort,, Cauais aye and sad damage (or Stun
tntsoon). Do not ut . eyes, on stun, or on
cIotJwig , wi QnQ9 s or ac. afield and ruso
evus wMn han 5Wiq. $wmhi or fatal if IwstI .
CAporo na rest
II
May b. fatat if swallowed ( at.d or absorbed
Is. sad]. Do fa._g fs vipOrS ( * or
sy mstj. 00 ñCt get as eyes, on Stat, or on
U Is (ropoats Mt ad statements mqus.d.].
ad atamm.nt ut3
Cau..s ey . (and stat] ITtlabon, Do not g.t as iy ,
on stat, or on ctouw sg. t4wtnfij if swallowed. tAp-
u e rest ad statement rsquasd,.)
I
Hmftj if iesfIow,d (lifistud or adeftid ifYot 1 Use
iEasL Avoid bruIsing v$pCV$ (d.mt or foray met].
Aved contact wilt stai (ayes or clotfisigi. (Aporo.
Avc ’4 contact wilt sldn, eyes or cloltwsg, In ca.. of
contact bomadststy fkaSi eyes or stat anus ptsniy of
waiw. Gst m. st
N
rev aid statement ru sdJ
(No prec.usctie ’,’ stalensents r Wsd.3_
abeneon if btwauen getilats.
(NO orecautton.y staisma , ,t. ,sq j
-------
lift. 40—Prots1ion of Environment
§ 162.10
placement of the statement of practi-
cal treatment is some reference such
as “See statement of practical treat•
rnent on back panel” appears on the
front panel near the word “Poison”
and the skull and crossbones.
(B) Other toz c t cafe gor es. The
statement of practical treatment is not
required on the front panel except as
described in paragraph(h)(1)(ill)(A) of
this section. The applicant may. how-
ever, include such a front panel state-
ment at his option. Statements of
practical treatment are, however, re-
quired elsewhere on the label In
accord with paragraph (h)(2) of this
section If they do not appear on the
front panel.
(lv) Placement and prominence. All
the require front panel warning state-
ments shall be grouped together on
the label, and shall appear with suffi-
cient prominence relative to other
front panel text and graphic material
to make them unlikely to be over.
looked under customary conditions of
purchase and use. The following table
shows the n rdmum type size require-
ments for th. front panel warning
statments on various sizes of labels:
Size 0 IaO.4 front 01111$ In
m d lii
P r
w h1 jl
C10d 1
o t
C (U 1 1
AbG i i5 IOI0......_._...._ .._.. .-
Abo S 10 Ia 15 ...........___
5
lOi
12 i
141
is
5
S
S
10
AbCys 15 to 30...._.-— —. —-.---——
.
(2) Other reqwired warnings and pre-
cautionary scafements. The warnings
and precauXtonary statements as re-
quired below shall appear together on
the label under the general heading
“Precautionary Stacement.s” and
under appropriate subheadings of
‘Hazard to Humans and Domestic An!-
maLt,” “Environmental Hazard” and
“Physical or Chemical Hazard.”
U) Ha.zard to humsna and domestic
animals. (A) Where a hazard exists to
humans or domestic aninl2Is. precau-
tionary statements are required mdi-
eating the particular hazo-rd, the
route(s) of exposure and the precau
tions to be taken to avoid accident,
injury or ds i ge. The precautionary
paragraph shall be immediately pre-
ceded by the appropriate hazard slgsial
word.
(B) The following table depicts typi-
cal precautionary statements. These
statements must be modified or ex-
panded to reflect specific hazards.
T a iMy
sstv
Prscamqt* stalumsiwub tastily *sgot
— 0 1st. hi4 A or dii t t ’f
Sit . s . ta such
$ (Pc JS* I I -J W Sd or $ ‘ VI$1
Svsa a t). 00 no’. srssm. ywuor Ci or sorsy
C .IflCst . ‘ S S and sti’. duwug. ror un
knw.&. .4. Os nsi ge ii u an ill’.. or an
Os gil t sywu. an ilit a, an o1Wg
( “cii 9 . 1 51 . —* 01 .ma5 a wcsn tw re.
.51s t ).
.IJi .. .g . WSV ojtj-, or liii i d aid n bsr
.ss wflai fl. ng. Msinidi or f d
tA,,....,. fist Id w* r9.inod .3
g
usy be tat S .sio..Id WtS5 or aa ot
lus Ste Idni. 00 t stls v ors Citel or-
emit ‘nil). 0 . nst at ayes, an ii, or an
J.4 CAoui fist Id ,*h1a K ,s jnij.
C ease sys Land stil h .w.M . . 00 ch gil i i ayes.
on slit, or an lt1ng. Haniti it p .i.aio..sa. LAp.
*. ‘ .a fate aid .-it rs imit3
p ______
HeIdi S e.da ’. ...4 (Wised or aitwUId bwou 5 ’ . St.
stil. MId b..m ..g . ‘agim t su or sony at1
Avid c ‘m m aId (ayes or ii ., .J. (Ap o.
Most am slit. ayeS or .M51 4 In aSS Oh
anlaa Inwnsiiluly flail ayes or aId wich phsn’.y at
sty. Gil ms if Jfil.&,.. 9sr ts,
i v .
— fist slit statam sdi.
(N i OUst51IIesY ehhimsnN r. Idt3
(Ni rucIdchty stIIULIJIS r.esedi
(11) Znvl,’onmental hazards. Where a
h ’.’d exists to non target organ4-” .’
excluding htIn ’ ..ri .n and domestic an!-
i ’ . ’ .s1a precautionary statements are re-
qufred stating the nature of the
ha .rd and the appropriate precau-
tions to avoid potential accident,
Injury or le-m ge . Examples of the
h rd statements and the circum-
-------
Chapter I—Environm.nta Protection Agency
§ 162.10
stances under which they are requLred
follow:
(A) U a pesticide Lntended for out-
door use contain.s an active ingredient
with a mammalian acute oral LD , of
100 or less, the statement ‘This Pesti-
cide is Toxic to Wildlife” is required.
(3) U a pesticide intended for out-
door use contains an active ingredient
with a fish acute LC ,. of 1 ppm or less,
the statement “This Pesticide Is Toxic
to Fish” Is required.
(C) U a pesticide intended for out-
door use contains an active ingredient
With an avian acute oral LD,. of 100
mg/kg or less, or a subacute dietary
LC,. of 500 ppm or less, the statement
“This Pesticide is Toxic to WUdiife” is
required.
(D) U either accident history or field
studies demonstrate that use of tLie
(I) Dfreetioizs for Use—U) General
requirements—.(I) Adequac,j and cZar-
it t , of directions,, Directions for use
must be stated In terms which can be
easily read and understood by the
average person likely to use or to su-
pervtse the use of the pesticide. When
followed, directions must be adequate
to protect the public from fraud and
from personal Injury and to prevent
unreasonable adverse effects on the
environment,,
(Ii) Placement of directions for use.
Directions may appear on any portion
of the label provided that they are
conspicuous enough to be easily read
by the user of the pesticide product,
Directions, for use may appear on
pesticide may resuit En fatality to
birds, fish or mammals, the statement
“This pesticide is extremely toxic to
wildlife (fish)” is required.
(E) For uses involving foliar applica-
tion to agricultural crops. forest ,s, or
shade trees, or tot mosquito abate-
ment treatments, pesticides toxic to
pollinating inseet,s must bear appropri-
ate label cautions.
(F) For all outdoor uses other than
aquatic applications the label must
bear the caution “Keep out of lakes,
ponds or streams. Do not contanjinate
water by cleaning of equipment or dis-
posal of wastes.”
( lii) Phitswal or chemical lza.zards,
Warning statements on the flarnmabjl.
Ity or explosive char cteristlcs of the
pesticide are required a,s follows
printed or graphic matter which so-
companies the pesticide provided that
(A) U required by the Agency, such
printed or graphic matter is securely
attached to each package of the pesti-
cide, or placed Within the outside
wrapper or bag;
(3) The label bears a reference to
the direction., for use In accompanying
leaflets or circular.,, such as “See di .
.rectlons In the enclosed clrcular” and
(C) The Administrator determines
that It Is not necessary for such direc-
tions to appe on the label.
(UI) Exceptions to requirement for
direction for use— (A) Detailed direc-
tions for use may be omitted from la-
beling of pesticide, which are Intended
. pow
(A) Puu *jm COI?AIMR$
F1MI, 00 1 1 W 11 or bilow 20 d a laar c* at E.zw* tIwv , s. Conas to Wur ss. Kate tram
q tWO, $ W L 1W h.t*sd eatocus. Do ‘tot p ’ mlcWte or s.,
cun s . ‘ ‘i ts to ta, sie s 130’ F o
isufl — 1W s 20” F iw not $0 ’ F or d me Rwwnooto. taWor s ws. (isp , tr, ,,
1 1am. — - - m n . ‘ist I l N, a *w e. ws*, 1W oØ flame, Do not ounca,s or coii t ,
o 6 N i f’ m me me ,.. ____ to ts,toeras,.s $0 s 130’ F . camo Nin
As, oOwr cnto . __ Coni...w W ‘ScaNS, Do not i m oor n hca or open
flenie. Do not or i. cot ’ . ‘ -row, . to
oee 130’ F n p came m.aiei,
At or b 20’ F
Above 20’ F 1W not 60’ F.
Above 10’ F oW not owor 150’ F
E4sr... ae 11sameD e. Wisp a tram 1W
I se,
. , manwnoiMa. Keep awsy from ieee and o s , flsp,
Do not use or otor. nesr heel or open llama,
-------
§ 162.10
Title 40.—Prot.ctlon of Environment
for use only by manufacturers of prod.
uct.s other than pesticide products In
their regular rna.nufacturing processes.
provided that
(1) The label clearly shows that the
product Ls intended for use only in
manufacturing processes arid specifies
the type(s) of products involved.
(Z) Adequate information such as
technical data sheets or buuletins. Is
available to the trade specifying the
type of product involved and its
proper use In manufacturing process-
(3) The product will not come Into
the hands of the general public except
after Incorporation into finished prod-
ucts: and
(4) The Adm nLttrator determines
that such directions are not necessary
to prevent unreasonable adverse ef-
fects on man or the environment.
(B) Detailed directions for use may
be omitted ‘from the labeling of pesti-
cide products for which sale Is limited
to physlci&flL veterln*rtaflL or drug-
gists, provided tb*&
(1) The label clearly states that the
product Is for use only by physicians
or veterinarians:
(2) The A stritor determines
- that such directions are not nsceuary
to prevent unseasonable adverse ef-
fects on man or the environment: and
(3) Th. product is also a drug and
regulated under the provisions of the
Federal Food, Drug and Cosmetic Act.
(C) Detailed directions f or use nay
be omitted from the labeling of pesti-
cide products which are intended for
use only by formulators In preparing
pesticides for sale to h. public, pro-
vided that:
C l) There Is information readily
available to the formulators on the
composition, toxicity, methods of use,
applicable restrictions or limitations,
and sffect1venI of the product for
pesticide purposes:
(2) The label clearly states that the
product La Intended for use only In
manufacturing, formulating, mixing ,
or repe 1 ’f for use as a pesticide and
specifies the type(s) of pesticide prod-
ucts jnvolved
(3) The product as finally manufac-
tured. formulated. mixed, or repack-
aged Is registered; and
(4) The Administrator determines
that such directions are not necessary
to prevent uru-ea .sonable adverse ef-
fects on man or the environment.
(2) ContenU of Dfrectioiu /0? (lie.
The directions for use shall include
the following, under the headings ‘Di-
rections for Use”:
(1) The statement of use classifica-
tion as prescribed in 162.10(j) immedi-
ately under the heading “Directions
for Use.”
(U) Immediately below the state.
ment of use classIfication, the state-
ment “It Is a violation of Federal law
to use this product in a manner incon-
sistent with Its labeling.”
(1.11) The site(s) of application, as for
example the crops. anIrn ) . areas, or
objects to be treated.
(lv) The target pest(s) associated
with each site.
Cv) The dosage rate associated with
each site and pest.
(vi) The method of application. in-
cluding instructions for dilution. If re-
quired, and type(s) of application ap-
paratus or equipment required.
(vii) The frequency and ttrnlpg of ap-
plications necemary to obtain effective
results without cauz1ng unreasonable
adverse effects oaths environment.
(viii) Specific limitations on reentry
to areas where the pesticide has been
applied, meeting the requirements
concerning reentry provided by 40
C??. Part 170.
(ix) Specific directions concerning
the storage and disposal of the pesti-
cide and its container, meeting the re-
quirernenta of 40 C??. Part 165. These
InstrUCtiOns shall be grouped and
appear under the beading “Storage
and DispoalL” This h.-dlng must be
set In type of the same minimum sizes
as required for the child lq. rd warn-
ing (See Table In I 1B2.lO(hXl)(iv).)
(x) Any limitations or restrictions on
use required to prevent unreasonable
adverse effects, such as:
(A) Required Intervals between ap-
plication and harvest of food or feed
crops.
(B) Rotational crop restrictions.
(C) Warnings as required against use
on certain crops, animals, objects,’ or
In or adjacent to certain areas.
CD) CReservedl
-------
C iapt.r ‘— ‘En’vkonmsntcI Protection Agenc
§ 62.l1
CE) For restricted use pesticides, a
statement that the pesticide nay be
appUed under the direct s jpervision of
a certified applicator who is not phys-
lcaiiy present at the site of appllca ion
but nonetheless available to the
person applying the pesticide, unless
the Agency has determined that the
pesticide may only be applied under
the direct supervision of a certified ap-
pilcator who is physically present.
(F) Other pertinent information
which the Adnffin trator determines
to be necessary for the protection of
man and the environment,
(j) Statement of Use Class(fication.
By October 22, 1916, all pesticide prod-
ucts must bear on their labeLs a state-
ment of use classification a.s descrlbe
In paragraphs (j)(1) and (2) of this
section. Any pesticide product for
which some uses are classified for gen-
era! use and others for restricted use
ali ll be separately labeled according
to the labeling standards set forth in
this subsection, and shall be marketed
as separate products with different
registration numbers, one bearing di-
rections only for general use(s) and
the other bearing directions for Ye-
stricted usec3) except th t If a product
has both restricted use(s) and general
use(s), both of these uses may appear
on a product labeled for restricted use.
Such products shall be subject to the
provisions of I 162.10(j)(2).
(1) Generai Use CZass(/ caUon. Pest!-
dde products bearing directions for
use(s) classified general shall be Is-
beled with the exact words “Genera!
Classification” 4 mmedlately below the
heading “Dfre ‘4ons for Use.” And ref.
erence to the general -qlf1cat1on
that suggests or Implies that the gen-
eral utility of the pesticide extends
beyond those purposes and uses con-
tained In the Directions for Use will be
considered a false or misleading state-
ment under the statutory definitions
of m1sbranrHi g.
(2) RestrIcted Use aasslflcizfio, .
Pesticide products bearing direction
for use(s) classified reàtrlcted
bear statements of restricted use claa-
aificatlon on the front panel as de-
scribed below:
(I) ‘,ont panel statement of restrict-
ed isse cla.ssjflcaglon. (A) At the top of
the front panel of the label, set In type
of the same mnimum sizes a required
for human hazard signal words (see
table in 162.1O(hX1th ), and appear-
ing with sufficient prominence relative
to other text and graphic aaateriai on
the front panel to make it u.nlikely to
be overlooked tinder customary condi-
tloo.s of purcha.se and use, the State-
menc “Restricted tTse Pescicide’ shall
appear.
(B) Directly below this statement on
the front panel, a summary statement
of the terms of restriction imposed as
a precondition to registration shall
appear. U use Is restricted to certified
applicators, the following statement Is
required: “For retail sale to and use
only by Certified Applicators or per-
sons under their direct supervision and
only for those uses covered by the Cer-
tified Applicator’s certification.” If,
however, other regulatory restrictions
are Imposed, the Administrator will
deflne;tbe appropriate wording for the
terms bf restriction by regulation.
(It) 4ctvertlsing. tfteserved]
,140 FRI 2826S, July 3. 1913: 40 FR 32329.
Aug. 1.j1975; 40 FR 36571. Aug. 21. 1915, u
amend d at 43 FR 5786, Feb. 9, 1978)
I Ill Criteria (or d*tannlnatlons of Un-
nabi. adv.r,e .ff.eJa
(a) Lena for !ulsance of Notic of
Intent to Deny Registration, el
Regist ion, or to Hold a Hers ng—
(1) PnØsu ptloi*. (I) A rebu e pre-
aumpt on all arise that a tice of
Intent to d registration p t to
sectiofl 3(cX of the Act, notice of
intent Ito àsn reglatra pursuant
to sec$lan 8(b ) of e Act, or a
notice l° Intent ho a hearing to
detern 1ne wheth e registration
shouldi be cancell r denied, as ap-
propr1 te, shall be ed, upon a de.
termln t1on by th tor that
the pesticide m or ceeds any of
the criteria for It set rth In para-
graph (a)(3) 0 this sectlo Upon such
deterwffi t,j the trator
h J1 Iásue otice by certifi n2*II to
theappli torreglstrant,aa ecase
may be, tatlng that the appli t or
regis t has the opportuni to
sub evidence In rebuttal of oh
p ptlon In accordance with -
a)(4) of this section. The app -
t o registrant shall have forty-fly
-------
1 PPFM IX P/-2
LABELING RFWIR 4FNI’S (P ThE FIFRA, AS N4E?I)FD
I
ITFII I LABEL ELFII 1P I
APPLIcABILITY I PLAa 7lENF (N LABEL
OF RE JIRFI*21P I REC JIRE ) I PREFERR )
1 I Product nane I
I I
All products I
Front panel I Center front
I panel
is not the must
2 I Q’zI! any nane I All products
I and address
Wne I Bottan front
panel or end
registrant
be qualified L y Packed for . . •,“
Distributed
M etc.
I I
3 I Net contents All products
I
I of label text
b 4 . . • ,
NJne I Bottcin front May be in metric units in addition to
I panel or end I U.S. units
I of label text I___________________________
be in similar
size and
4 I EPA i q. Th.
i
All products
NDne I Front panel
I
type
parallel to other type.
the container instead of
5 1 EPA Fst. ! .
I
I
I
1 All products
I
I
ne
Front panel, May a ear
I iimnediately the label.
I beforeor
I followinq
Re. No.
I
Text must parallel with other text
6A
6B
Ingredients
statement
pounds/qallon
1 All products
Liquid products
Front panel
I
I Front panel
Ininediately
followin
product nane
Directly below
I on the panel.
I__________________________________
I
I
I
statement I where dosaqe
I given as lbs.
I
. the main
ingredients
ai/unit area
7 Front panel I All products
I precautionary
Front panel
I
statement
1 All front panel precautionary statements
I must be grouped toqether, preferably
blocked.
stat nents I_______________
7A I Keep C)it of 1 adt All products
I of thildren I
I (thild hazard I
1 Front panel 1
I
Abocie signal
rd
Note type size requirements.
7B
Iwarning) I
1 Signal tgrd I All products Front panel I Thinediately
I I belowchil-d
I I. I hazard
I I I Iwarning
I te type size requirements.
I
I____________
-------
APPEM)IX P/-2 (continued)
I I APPLICABILITY j ()J LABEL
ITEM LABEL ELEMENT I OF REX JIREMENr I REX JIRED 1
PREFERRED I (DI 4€WrS
7C I Skull & cross- I All products I Front panel ) Both in close 1
I bones and rd I which are Cat— I I proximity to I
I POISON (in red) I eqory I based I I signal rd
I tonoral,der— I I I
I mal, or inhala— I I
tion toxicity I
7D I Statement of I All products I Category I: I Front panel
I practical I in Cateqories I Front panel I for all. I
I treatment I I, II, and III I unless refer- .I I
I I I ral statement I I
lisused. I I
I I lOthers: I I
I I I Groupedwithj I
I I I sidepanel I
precautionary I
statements.
7E I
Referral
All products
I________________
Front panel 1
I______________________________________
-statement - where—pre--- I -- -._____
1 I cautionary
I]-abelinq I I
I Ia earson I I
I lotherthan I I
front panel.
I
I
8 1 Side/back panel F All products None I ‘1 p or side Must be grouped under the headings in
I precautionary I I I of back panel 8A, 8B, and 8C; preferably blocked.
I statements I I I precedinq I
I I I I directions I
I I______ Iforuse
8A Hazards to I All products 1 ne 1 Same as above Must be preceded arpropriate signal
I hixnans and I in Categories I
I danestic I I, II, and III I I
Iani.mals I I I
8B I E vircrinenta]. I All products
hazards I
None I
I
Same as above I F wircanental hazards incltrle bee
-------
APPEM)IX P/—2 (continued)
I 1 APPLICABILITY I PLAC1 74FNF ( 1 LABEL
ITFZ4 I LABEL ELF ’1F V I OP REQUIRF 4F TP I REQUIRED PREFERRED I CX1’f4FNFS
8C I Physical or All pressurized I None
I chemical products, othersi
I hazards I with flash I I
I points under I
150°F I
Sane as above
I
I
I
I
Incindes
statement of the terms of
9A I Restricted All restricted
I block products
I
Top center I
of front
panel
Preferably
a
blocked I restriction. The wrds “RESTRICTE D USE
I PESTICIDE” u ist be sane type size as
I signal rd.
I
9C I Misuse I All products Ininediately
I statement I I foliowinq I I
I I I headingof I I
I I directions I
I I foruse I
bA
I
Reentry I All
statement I cholinesterase
I inhibitors
In the
directions
for use
I n inediately I
after misuse I
statement I
and distin—
1OC Storage and I All products In the 1 Invnediately I Must be set
1 disposal block I directions I before I quishable fran fran other directions
I I I for use I specific I for use.
I I I I directions
I I I foruseor I
I I attheendof I
I I I I directions I
I I I foruse
I
be in metric
1 1 U.S. units
101) I Directions I All products
Iforuse I
Wne I None
May
as
I
-------
Appendix 1V-3
PHYSICAL —CHEMICAL HAZARDS
Criteria
Required Label Statement
I. pressurized Containers
A. Flashpoint at or below
20°F: or if there is a
flashback at any valve
OPefl iflQ.
B. Flashpoint above 20°F
and not over 80°F; or
if the flame extension
is more than 18 inches
lonq at a distance of
6 inches from the
valve opening.
C. ALL OTHER PRESSURtEZED
CONTA INERS
ii. Non—pressurized Containers
A. Flashpoint at or e1ow
20°F.
B. Flashpoint above
and not over 8fl°F
C. Flashpoirtt over 8 °F
and not over 150°F.
D. Flashpoint above
150°F.
Extremely flammable.
Contents under pressure.
KeeP away from fire, sparks,
and heated surfaces. Do not
puncture or incinerate
container. Exposure to
temPeratures above 130°F
may cause burstinq.
Flammable. Contents under
pressure. Keep away from
heat, sparks, and flame. Do
not puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces.
Flammable. Keep away from
heat and open flame.
Do not use or store near
heat and open flame.
None required.
-------
Appendix IV-4
ST0RP GE AND DISPOSAL INSTRUCTIONS FOR PESTICIDF S
All products are required to bear specific label instructions
about storage and disposal. Storage and disposal instructions
must be grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL. Products
intended solely for domestic use need not include the heading
“STORAGE AND DISPOSAL.” The STORAGE AND DISPOSAL heading
must appear in the minimum type size listed below:
I
I
Required type size
ISize of label
I
for the headinq
I front panel in
I
STORAGE AND DISPOSAL
Isquare inches
I
(all capitals)
I
I
I
110 and under
point
I
lAbove 10 to 15
.8 point
lAbove 13 to 30
.
.
.
•
. 10 point
I
lover 30. . . .
.
.
.
.
.
.
.
. .
.
. . . 12 point
I
I
I
Storage and disposal instructions must he set apart and
clearly distinguishable from other directions for use.
Blocking storage and disposal statements with a solid line is
suggested as a means of increasina their prominence.
A. Storage InstructiOfls
All product labels are required to have appropriate storage
instructions. Specific storage instructions are not prescribed.
Each reqistrant must develop his own storage instructions,
considering, when applicable, the following factors:
1. Conditions of storage that might alter the composition or
usefulness of the pesticide. Examples could be temperature
extremes, excessive moisture or humidity, heat, sunlight,
friction, or contaminating substances or media.
2. Physical requirements of storage which might adversely
affect the container of the product and its ability to
continue to function properly. Requirements might include
positioning of the container in storage, storage or damage
due to stacking, penetration of moisture, and ability to
withstand shock or friction.
3. Specifications for handling the pesticide container,
including movement of container within the storage area,
oroper opening and closing procedures (particularly for
opened containers), and measures to minimize exposure
while ooening or closina container.
-------
Appendix IV-4
(continued)
4. Instructions on what to do if the container is damaged in
any way, or if the pesticide is leaking or has been
spilled, and precautions to minimize exposure if damage occurs.
5. General precautions concerninq locked storaqe, storaqe in
original container only, and separation of pesticides
durinq storage to prevent cross-contamination of other
pesticides, fertilizer, food, and feed.
6. General storage instructions for household products should
emphasize storage in original container and placement in
locked storage areas.
R. Pesticide Disposal Instructions :
The label of all products, except those intended solely for
domestic use, must bear explicit instructions about pesticide
disposal. The statements listed below contain the exact wordinq
that must appear on the label of these products:
1. The labels of all products, except domestic use, must
contain the statement, “Do not contaminate water, food,
or feed by storage or disposal.”
2. Except those products intended solely for domestic use,
the labels of all products that contain active ingredients
appearing on the “Acutely Hazardous’ t Commercial Pesticide
Products List (RCRA “F” List) at the end of this appendix
or are assigned to Toxicity Cateqory I on the basis of
oral or dermal toxicity, skin or ye irritation potential,
or Toxicity Category I or II on the basis of acute inhala-
tion toxicity must bear the following pesticide disposal
statement:
“Pesticide wastes are acutely hazardous. Improper dis-
posal of excess pesticide, spray mixture, or rinsate is
a violation of Federal Law. If these wastes cannot he
disposed of by use according to label instructions,
contact your State Pesticide or Environmental Control
Agency, or the Hazardous Waste representative at the
nearest EPA Regional Office for guidance.”
The labels of all products, except those intended for
domestic use, containinq active or inert ingredients
that appear on the “Toxic” Commercial Pesticide Products
List (RCRA “F” List) at the end of this appendix or
presently meet any of the criteria in Subpart C, 40 CFR.
261 for a hazardous waste must bear the followinq pesticide
disposal statement:
-------
Apøendix IV-4
(continued)
“Pesticide wastes are toxic. Improper disposal of excess
pesticide, spray mixture, or rinsate is a violation of
Federal Law. If these wastes cannot be disposed of by
use accordinq to label instructions, contact your State
Pesticide or Environmental Control Agency, or the FTazardous
Waste representative at the nearest EPA Reqional Office
for guidance.”
Labels for all other products, except those intended for
domestic use, must bear the following pesticide disposal
statement::
“Wastes resultinq from the use of this product may be
disposed of on site or at an approved waste disposal
facility.”
3. Products intended for domestic use only must bear the
followinq disposal statement: “securely wrap original
container in several layers of newspaper and discard in
trash.”
C. Container Disposal Instructions
The label of each product must bear container disposal
instructions appropriate to the type of container.
1. All products intended for domestic use must bear one
of the following container disposal statements:
Container Type Statement
INon-aerosol products I Do not reuse container (bottle, can, jar). I
I(bottles, cans, jars)I Rinse thoroughly before discarding in trash.)
INon-aerosol products
I(bags)
Do not reuse bag. Discard bag in trash.
I
lAerosol products 1 Replace cap and discard containers in
1 trash. Do not incinerate or puncture. I
-------
Appendix IV-4
(continued)
2. The labels for all other products must bear container disposal
instructions, based on container type, listed below:
Container Type Statement
IMetal
Icontainers
I (non-aerosol)
I
Triple rinse (or equivalent). Then offer I
for recycling or reconditioninq, or puncture?
and dispose of in a sanitary landfill, or by?
other procedures approved by state and local?
authorities.
IPlastic containers Triple rinse (or equivalent). Then offer I
I I for recyclinq or reconditioning, or Puncture?
I I and dispose of in a sanitary landfill, or
I I incineration, or, if allowed by state and I
local authorities, by burning. If burned, I
I stay out of smoke. I
IGlass containers
I
I
Triple rinse (or equivalent). Then dispose I
of in a sanitary landfill or by other
approved state and local procedures.
IFiber drums Completely empty liner by shakinq and
Iwith liners tappinq sides and bottom to loosen clinging I
I I particles. Empty residue into application I
I I equipment. Then dispose of liner in a I
I sanitary landfill or by incineration if I
I I allowed by state and local authorities.
I I If drum is contaminated and cannot be I
reused 1 , dispose of in the same manner.
IPaper and I Completely empty bag into application I
Iplastic baqs I equipment. Then dispose of empty bag in I
I I a sanitary landfill or by incineration, I
I I or, if allowed by State and local I
I I authorities, by hurninq. If burned, stay I
I I out of smoke. I
ICompressed gas I Return empty cylinder for reuse (or I
Icylinders I similar wordinq) I
-/ Manufacturer may replace this phrase with one indicating
whether and how fiber drum may be reused.
-------
Appendix IV-4
(continued)
pesticides that are hazardous wastes under 40 CFR 261.33(e) and (f)
when discarded.
“ Acutely Hazardous” Commercial pesticides (RCRA “E” LiSt
Active inqredients, (no inerts)
Ac role in
Aid icarb
Al d tin
Ailyl alcohol
Aluminum phosphide
4 —AminOPyt id me
Arsenic acid
Arsenic pentoxide
Arsenic trioxide
Calcium cyanide
Carbon disuifide
p_ChlorOaflil me
CvanideS (soluble cyanide salts, not specified elsewere)
Cyanogen chloride
2_CyciohexYi- 4 ,6_dinitrophenoi
Dieldrifl
O,O-Diethvl S_F2_ethYlthi0)ethYl ’ PhOSph0t0 t 0ate
(djSUlfOtOfl, Di-SYStOn)
0,0-DiethYl O-pvraziflvi h 0 SPhOrOthi0ate (ZinoPhos)
DimethOate
O,O —Dimethv]. o_p_nitroPhenY’- phosTDhorothioate (methyl parathion)
4,6_Dinitroo_ctesol and salts
2,4 DinittoPheno’
oinoseb
Endosuif an
Endothail
Endrin
FamphUr
Fl uoroace tam ide
HeptaChiOr
Hexaflethyl tetraphoSPhate
HydrOcyafliC acid
Hydrogen cyanide
Methomyl
alpha_NaPhthYith] 0utea (ANTtJ)
Nicotine and salts
OctamethYlPYrOPh0sPh0 m e (OMPA, schradan)
Parathion
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Appendix IV-4
(continued)
“ Acutely Hazardous” Commercial Pesticides (RCRA “E” List)
Active Ingredients continued :
Phenylmercuric acetate (PMA)
Phorate
Potassium cyanide
Propargyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacetate
Strychnine and salts
O,O,O,O—Petraethyl dithiopyrophosphate (suifotepp)
Tetraethyl pyrophosphate
Thallium sulfate
Thiofanox
Tox aphene
War far in
Zinc phosphide
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Appendix IV-4
(continued)
“ Toxic” Commercial Pesticide Products (RCRA “F” List)
Active Inqredients :
ce tone
Acrylonitrile
Amitrole
Ben zene
Bi s( 2—ethvlhexyl )nthalate
Cacodvlic acid
Carbon tetrachioride
Chioral (hydrate)
Chlordane (technical)
Chlorohenzene
4 -Chioro—ir-cresol
Chloroform
o-Chlorophenol
4_Chloro—o-toluidine hydrochloride
Creosote
Cresylic acid
Cyclohexafle
DecachlorOOCtahYdrO_l,3,4_methefl o_2H_cYclotafc, _Pentalen 2 -0
(kepone, chlordecone)
1, 2_Dibromo-3--chlOrOPrOPafle (DBCP)
Dibutyl phthalate
s-3,3 -(Dichloroallvl diisoprOPYlthiOCarbamate (diallate, Avadex)
o-DichlOrObeflZefle
p-DichlotObenZefle
Dichlorodifluoromethane (Freon 12®)
3,5_Dichloro_N_(l,ldimethvl-2—PrOPYnVU benzamide (pronamide,Kerb)
Dichioro diphenyl dichioroethafle (DDD)
Dichioro diphenyl trichioroethane (DDT)
Dichlorethyl ether
2,4_Dichiorophenoxyacetic, esters and salts (2,4—D)
1, 2_DichloroproPafle
1, 3—DichioroproPafle (Telone)
Dimethyl phthalate
Ethyl acetate
Ethyl 4,4’ —dichlorobenZiiate (chlorobenzilate)
Ethylene dibromide (EDB)
Ethylene dichioride
Ethylene oxide
Formaldehyde
Furfural
Hex a ch 1 or obe n zen e
Hexachiorocyclopentad iene
Hexachioroetharte
Hydrofluoric acid
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Appendix IV—4
(continued)
“ Toxic” Commercial Pesticide Products (RCRA “F” List)
Active Inaredients :
Isobutyl alcohol
Lead acetate
Lindane
Maleic hydrazide
Mercury
Methyl alcohol
Methyl bromide
Methyl chloride
2,2’-Methylenehis (3,4,6-trichloroøhenol) (hexachiorophene)
Methylene chloride
Methyl ethyl ketone
4-Methyl-2-pentanone (methyl isobutyl ketone)
Naphthalene
Nitrobenzene
p-Ni trophenol
Pentachioroethane
Pentachloronjtrobenzene (PCNB)
Pen tacloroph enol
Phenol
Phosphorodithioic acid, 0,0—diethyl, methyl ester
Propylene dichioride
Pyrid me
Resorcinol
Saf role
Selenium disulfide
Silvex
1 , 2,4, 5-Petrachlorobenzene
1,1,2, 2—Petrachloroethane
Tetrach loroethv lene
2,3, 4,6—Tetrachlorophenoi
Thiram
To 1. u en e
1,1, l—Trichloroethane
Trichioroethylene
Trichiorornonofluoromethane (Freon il®)
2,4, 5—Trichlorophenol
2,4, 6—Trichlorophenol
2,4,5—Trichiorophenoxyacetic acid (2,4,5—T)
Xylene
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Appendix IV—4
(continued)
“ Toxic” Commercial Pesticide Products (RCRA “F” List)
Inert Ingredients :
Acetone
Acetonitrile
Ace tophenone
Acrylic acid
Aniline
Ben zene
Ch lorobenzene
Chloroform
Cyclohexane
Cyclohexanone
DichiorodifluorOmethane (Freon l2 )
Diethyl phthalate
Dimethyl amine
Dimethyl phthalate
1 ,4—Dioxane
Ethylene oxide
Formaldehyde
Formic acid
Isobutyl alcohol
Meleic anhydride
Methyl alcohol (methanol)
Methyl ethyl ketone
Methyl methacrylate
Naphthalene
Saccharin and salts
Th iou re a
Toluene
1,1 ,l—Trichloroethane
1,1 , 2—Prichloroethane
Trichiorofluoromethane (Freon ll®)
Vinyl chloride
Xylene
•U.S. GOV IthM T PRINTING OFVIC , t9N 46l_l17/3 9Ol.
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