r/EPA
United Stvtti
Environments! Protection
AgMiey
Offlwof
Pwfcfata and Toxic SubttancM
Wnhington OC 20460
PattiCKtas
August 1986
Guidance for the
Reregistration of
Pesticide Products
Containing
Methyl Bromide
as the Active Ingredient
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GUIDANCE FOR THE
REREGISTRATION OF PESTICIDE PRODUCTS
CONTAINING
METHYL BROMIDE
AS THE ACTIVE INGREDCENT
CASE NUMBER 0335
CAS REGISTRY NUMBER 74-83-9
AUGUST 1986
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20460
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TABLE OF CONTENTS
Page
I. Introduction
II. Chemical(s) Covered by this Standard 4
A. Description of Chemical
B. Use Profile
III. Agency Assessment . . . . . . . . . . . . . 6
A. Summary
B. Preliminary Risk Assessment
C. Science Findings
D. Tolerance Reassessment
IV. Regulatory Position and Rationale. . . . . . 13
A. Regulatory Positions
B. Criteria for Registration
C. Acceptable Ranges and Limits
D. Required Labeling
V. Products Subject to this Standard 31
VI. Requirement for ‘Submission of Generic Data 33
A. What are generic data?
B. Who must submit generic data?
C. What generic data must be submitted?
D. How to comply with DCI requirements
E. Procedures for requesting a change in protocol
F. Procedures for requesting extensions of time
G. Existing stocks provisions upon suspension or
cancellation
VII. Requirement for Submission of Product—Specific Data. . . 38
VIII. Requirement for Submission of Revised Labeling 39
IX. Instructions for Submission 40
A. Manufacturing use products (sole active)
B. Manufacturing use products (multiple active)
C. End use products
D. Intrastate products
E. Addresses
1
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APPENDICES
Page
I. DATA APPENDICES
Guide to Tables 43
Table A 45
Table B • • • • . . . . . 75
II. LABELING APPENDICES
Summary of label requirements and table 78
40 CFR 162.10 Labeling Requirements 86
Physical/Chemical Hazards Labeling Statements 95
Storage Instructions 96
Pesticide Disposal Instructions 97
Container Disposal Instructions 98
III. USE INDEX APPENDIX
Table of Contents 99
Use Index . 103
IV. BIBLIOGRAPHY APPENDICES
Guide to Bibliography . . 179
Bibliography . 181
V. FORMS APPENDICES
EPA Form 8580—1 FIFRA §3(c)(2)(B) Summary Sheet . . . . 189
EPA Form 8580—6 Certification of Attempt to Enter Into
an Agreement with Other Registrants for
Development of Data . . . . . . . . . . 190
Product Specific Data Report 191
Formulator’s Exemption Statement 193
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I. INTRODUCTION
The Registration Standards Program
EPA has established the Registration Standards program
in order to provide an orderly mechanism by which pesticide
products containing the same active ingredient can be reviewed
and standards set for compliance with FIFRA. The standards
are applicable to reregistration and future applications for
registration of products containing the same active ingredient.
Each registrant of a product containing an active ingredient
subject to this Standard who wishes to continue to sell or
distribute that product must bring the product arid labeling
into compliance with FIFRA, as instructed by this Standard.
Pesticides have been grouped into use clusters and will be
reviewed on the basis of a ranking scheme giving higher
priority to (1) pesticides in clusters used on food and feed
crops; and (2) pesticides produced in large volumes.
The Registration Standards program involves a thorough
review of the scientific data base underlying a pesticide’s
registration. The purpose of the Agency’s review is to
reassess the potential hazards arising from the currently
registered uses of the pesticide; to determine the need for
additional data on health and environmental effects; and to
determine whether the pesticide meets the “no unreasonable
adverse effects” criteria of FIFRA. In its review EPA identifies:
1. Studies that are acceptable to support the data
requirements for the currently registered uses of the
pesticide.
2. Additional studies necessary to support continued
registration. The additional studies may not have been
required when the product was initially registered or may be
needed to replace studies that are now considered inadequate.
3. Labeling revisions needed to ensure that the product
is not misbranded and that the labeling is adequate to protect
man and the environment.
The detailed scientific review, which is not contained
in this document, but is available upon request’, focuses on
the pesticide active ingredient. The scientific review
primarily discusses the Agency’s evaluation of and conclusions
from available data in its files pertaining to the pesticide
1 The scientific reviews may be purchased from the Information
Services Section, Program Management and Support Division
(TS—757C), EPA, 401 M St. SW, Washington, DC 20460.
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active ingredient. However, during the review of these data
the Agency is also looking for potential hazards that may be
associated with the end use products that contain the active
ingredient. The Agency will apply the provisions of this
Registration Standard to end use products if necessary to
protect man and the environment.
EPA’s reassessment results in the development of a
regulatory position, contained in this Registration Standard,
on the pesticide and each of its registered uses. See
Section IV — Regulatory Position and Rationale. Based on its
regulatory position, the Agency may prescribe a variety of
steps to be taken by registrants to maintain their registrations
in compliance with FIFRA. These steps may include:
1. Submission of data in support of product registration;
2. Modification of product labels;
3. Modifications to the manufacturing process of the
pesticide to reduce the levels of impurities or contaminants;
4. Restriction of the use of the pesticide to certified
applicators or other specially trained individuals;
5. Modification of uses or formulation types; or
6. Specification of packaging limitations.
Failure to comply with these requirements may result in
the issuance of a Notice of Intent to Cancel or a Notice of
Intent to Suspend (in the case of failure to submit data).
In addition, in cases in which hazards to man or the
environment are identified, the Agency may initiate a special
review of the pesticide in accordance with 40 CFR Part 154
to examine in depth the risks and benefits of use of the
pesticide, If the Agency determines that the risks of the
pesticide’s use outweigh the benefits of use, the Agency
may propose additional regulatory actions, such as cancellation
of uses of the pesticide which have been determined to cause
unreasonable adverse effects on the environment.
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EPA has authority under the Data Call—In (DCI) provisions
of FIFRA see. 3(c)( 2 )(B) to require that registrants submit
data to answer our questions regarding the chemical, toxicological,
and environmental characteristics and fate of a pesticide.
This Registration Standard lists the data EPA believes are
necessary to resolve our concerns about this pesticide.
These data are listed in the Tables A, and B in Appendix I.
Failure to comply with the DCI requirements enumerated in
this Registration Standard may result in issuance by EPA of a
Notice of Intent to Suspend the affected product registrations.
Registrants are reminded that FIFRA sec. 6(a)(2) requires
them to submit factual information concerning possible unreason-
able adverse effects of a pesticide at any time that they
become aware of such information. You should notify the
Agency of any information, including interim or preliminary
results of studies, if those results suggest possible adverse
effects on man or the environment. This requirement continues
as long as your products are registered by the Agency.
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II. CHEMICAL COVERED BY THIS STANDARD
A. Description of Chemical
The following chemical is covered by this Registration
Standard.
Common Name: Methyl Bromide.
Chemical Name: Bromomethane.
CAS Registry No: 74—83—9.
EPA/OPP Pesticide Chemical Code: 053201.
Empirical Formula: CH 3 Br,
Trade Names: Brom_O_Gas®; Celfume®; Dowfume@; Embafume®;
Kayafume®; Meth O Gas®; Terr—O—Gas 100®.
Description of Physical Characteristics of Chemical:
Color: Colorless to light yellow.
Physical State: Gas at 25°C.
Odor: Odorless.
Melting Point: —94°C.
Boiling Point: 4°C.
Specific Gravity: 1.732 at 0°C.
Solubility: 1.75 g/lOOml H 2 0 at 20°C and 748 mmHg;
readily soluble in lower alcohols, ethers, esters, ketones,
halogeriated and aromatic hydrocarbons, and CS 2 .
Vapor Pressure: 1400 mmHg at 200 C.
Octanol/Water Partition Coeff.: log P = 1.19 (15.5:1).
Stability: Degrades by hydrolysis; 35—day half—life in soil.
Flammability: Nonflammable.
Explodability: Nonexplosive.
Storage Stability: Stable indefinitely upon storage.
Corrosion Characteristics: Non—corrosive to metal
containers; traces of water or acid may lead to corrosion
of application equipment.
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B. Use Profile
Type of Pesticide: Acaricide; Fungicide; Herbicide;
Insecticide; Nematicide; Rodenticide.
Pests Controlled: Insects; mites; rodents; plant
pathogens; nematodes; termites; weeds.
Registered Uses: Preplant, soil fumigation; stored
commodities (both raw agricultural commodities
and processed foods/feeds); greenhouses; termite
control; grain elevators; mills, ships and
transportation vehicles.
Predominant Use(s): Vegetables; tobacco; strawberries;
commodity/structural; government quarantine; ornamentals;
fruits.
Mode of Activity: Fumigation.
Formulation Types Registered: Gaseous, liquid under
pressure, or liquid.
Method of Application: Chisel application to field
soil; gravity distribution for smaller bins; forced
(recirculation) distribution systems; tarpaulin.
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III. AGENCY ASSESSMENT
A. SUMMARY
The Agency reviewed data submitted to support the regis-
tration of methyl bromide. Numerous data gaps exist for methyl
bromide and few definitive conclusions can be made. Based on the
available data, the Agency has reached the following conclusions.
1. Methyl bromide is considered highly acutely toxic. Applicator
exposure is a major concern with use of methyl bromide. Currently,
all methyl bromide products in containers of 1.5 lbs or greater
are restricted use. Applicator exposure during all types of
fumigation can be reduced through additional protective
measures (use of chloropicrin as a warning agent, restricted
use classification of 1.5 lb containers or less, interim
reentry levels, extensive label revisions and distribution
of an application manual with methyl bromide products providing
the necessary details for safe use of the product).
2. There are concerns regarding methyl bromide’s reproductive
and oncogenic potential due to its structural similarity to
animal reproductive toxins and oncogens, and its demonstrated
mutagenic effects. A rat oricogenicity study via inhalation was
recently completed in the Netherlands. The Agency has not yet
received this study for review, but preliminary findings are
reported to be negative. A mouse oncogenicity study via
inhalation is in progress at the National Toxicology Program.
Chronic toxicity data are required and further evaluation
will be conducted.
3. All tolerances for methyl bromide are currently expressed
in terms of inorganic bromide. However, residues of methyl
bromide per se, that Is actual residues of methyl bromide itself,
have been detected in a variety of foods. Metabolism, residue
and toxicology data are required, and a tolerance reassessment
will be conducted after these data are received.
4. While methyl bromide is believed to be highly toxic to
birds, fish and aquatic invertebrates, little hazard to nontarget
organisms is expected for all indoor and most outdoor uses
of methyl bromide. The practice of covering a treated area
with a tarpaulin following soil injection minimizes exposure
to nontarget organisms following outdoor uses. Methyl bromide’s
potential to leach to ground water is unknown. Environmental
fate and ecological effects data are required and further
evaluation will be conducted.
The missing data necessary to evaluate the environmental
and human risks associated with the use of methyl bromide
must be developed in order to maintain registrations of
products or register new products containing methyl bromide.
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B. PRELIMINARY RISK ASSESSMENT
Numerous data gaps exist for methyl bromide. The following
assessment is based on the available data and will be revised
after these data gaps are filled.
Methyl bromide is considered highly acutely toxic. Appli-
cator exposure is a major concern with use of methyl bromide.
For most products, use is already restricted to certified
applicators or those under the direct supervision of a certified
applicator. Based on data from the California Department of
Food and Agriculture, between 1981 — 1985 methyl bromide ranked
seventh as a cause of systemic pesticide poisonings, second
as the cause of hospitalization for occupational pesticide
poisonings and first in terms of total days hospitalized.
Ten deaths were due to methyl bromide in California from
1982 — 1985. All of these deaths were the result of unauthor-
ized persons reentering tarped structures that were being
fumigated, and were properly posted with warning signs. A
review of the occupational Illnesses and injuries from California
shows the circumstances leading to the overexposures can be
attributed primarily to inadequate employee training or
supervision, carelessness, or equipment failure.
The current Occupational Safety and Health Administration
(OSHA) standard for methyl bromide Is a maximum of 20 pm
(80 mg/M 3 ). A threshold limit value of 5 ppm (20 mg/Mi)
on a time weighted average, and a short—term exposure limit
of 15 ppm (60 mg/M 3 ) are recommended for methyl bromide by
the American Council of Government and Industrial Hygienists
(ACGIH).
The Agency requires through current labeling that after
fumigation of enclosed spaces with methyl bromide, the treated
area must be aerated until the level of methyl bromide is
below 5 ppm. This is a practical and attainable level which
can be achieved through current fumigation practices. This
interim level was established under the Label Improvement
Program for Fumigants, PR Notice 85—6, August 30, 1985.
Entry into the treated area is not allowed until the methyl
bromide level is measured, and determined to be below 5 ppm,
unless respiratory protection is worn (self—contained—breathing
apparatus (SCBA) or combination air—supplied/SCBA). The
Agency believes the measures required in PR Notice 85—6 will
reduce the risk to workers during fumigation in enclosed
spaces. The Agency will reevaluate the 5 ppm level based on
the toxicological data required in Table A, and an inhalation
study already submitted and under review. Also, the Agency
is requiring the addition of chloropicrin as a warning agent
during fumigation in enclosed spaces (except for commodity
fumigation), restricted use classification of all methyl
bromide products, and distribution of an application manual.
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The California Department of Food and Agriculture submitted
soil fumigation applicator exposure studies. These studies
measured the concentration of methyl bromide in the breathing
zone under normal use conditions and found the concentrations
generally do not exceed 5 ppm on a time weighted average. In
the event of a spill or leak, however, the concentrations
can exceed 5 ppm. Therefore, the Agency is not requiring
respiratory equipment to be worn during routine soil fumigation
use, but will require that approved respiratory equipment be
available and be used in case of a spill or leak. The Agency
believes additional protective measures should be taken to
reduce worker risks during soil fumigation. These measures
include adding chloropicrin as a warning agent, restricted
use classification of 1.5 lb containers or less that are
currently unclassified, and extensive revisions and improvements
in precautionary statements and use directions on the labeling
of all methyl bromide products covering safe use of the
product. See Section IV Regulatory Position and Rationale
for a detailed discussion of these measures.
C. SCIENCE FINDINGS
Most of the toxicological information on methyl bromide is
from published sources. These sources were analyzed in the Chemical
Hazard Information Profile (CHIP) dated September 28, 1984 and
revised February 20, 1985, by the US EPA, Office of Toxic Substances.
1. Acute Toxicity . Methyl bromide is considered highly acutely
toxic. The approximate LD 50 in rats is 214 mg/kg by the
oral route and 2700 ppm for a 30 minute exposure by the
inhalation route. In humans, 1,583 ppm (6.2 mg/L) was lethal
to adults exposed for 10 to 20 hours while 7,890 ppm (30.9
nig/L) was lethal after 1 1/2 hours. The lungs and kidneys
are affected by methyl bromide. No acute testing is required.
2. Subchronic Toxicity . Irish et al. (1940) reported methyl
bromide was toxic to rats, guinea pigs, and rabbits exposed
by the inhalation route for up to six months at 0.85 inglL,
and 0.42 mgIL was toxic to monkeys. The doses of 0.13 mg/L
for rats, guinea pigs and monkeys and 0.65 ing/L for rabbits
showed no toxic signs. Rats exposed to 65 ppm methyl bromide
for 100 hours or 55 ppm for 1080 hours showed no neurotoxic
effects. Rabbits exposed to 65 ppm for 100 hours showed
weight loss and neurological alterations. A 13—week rat
study in which methyl bromide was dissolved in peanut oil
and fed by gavage five times a week showed possible squamous
cell carcinomas of the forestomach at 50 mg/kg/day (Danse,
et al., 1984). The above studies are inadequate for regulatory
purposes. Subchronic inhalation studies in the rodent and
rabbit are required.
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3. Chronic Feeding and Oncogenicity . There are no adequate
data by any route to characterize the effects of long—term
exposure to methyl bromide. Concerns regarding oncogenic
effects arise due to its structural similarity to ethylene
dibromide (EDB) and dibromochioropropane (DBCP), both
animal oncogens, and because of its demonstrated rnutagenic
effects. A mouse oncogenicity study via inhalation is in
progress at the National Toxicology Program. A rat oncogenicity
study via inhalation has recently been completed in the
Netherlands. Although the Agency has not yet received this
study for review, preliminary findings are reported to be
negative. Oncogenicity and chronic feeding studies by gavage
in a rodent and non—rodent are required because tolerances
are needed.
4. Teratogenicity . Both rats and rabbits were exposed to either
20 or 70 ppm of methyl bromide in the air. The high dose caused
adverse maternal effects especially in rabbits (only one of 25
rabbits was alive at day 30). The low dose caused no adverse
effects in the dams or pups. The rat segment of the study is
adequate for regulatory purposes because a large number of
animals were dosed during the critical period of gestation, and
survival at the high dose was not as impaired as it was in the
rabbit. However, the rabbit segment of the study is not
adequate because only one rabbit survived the highest dose
tested. A teratology study in rabbits is required.
5. Reproduction . Concerns regarding reproductive effects arise
due to the structural similarity of methyl bromide to animal
reproductive toxins such as EDB and DBCP. A reproduction study
via inhalation has been submitted to the Agency and is currently
under review. Preliminary review of the study indicates no adverse
reproductive effects were detected. Because there is dietary
exposure, a reproduction study by gavage is required.
6. Mutagenicity . Methyl bromide is mutagenic in bacterial tests
using S. typhimurium, E. coli , and K. pneumoniae . Methyl bromide
is a direct—acting mutagen and induces primarily base—pair
substitution mutations. Methyl bromide has been shown to induce
gene mutations in Drosophila and at two different loci in
mammalian cells in culture. Methyl bromide does not appear to
be as potent a mutagen as ethylene dibromide in that more
chemical is needed to induce a response. Both bone marrow
and sister chromatid exchange tests are required. Other
genotoxic effects testing are required including an unscheduled
DNA synthesis test using rat hepatocytes and a test to determine
the effects on germ cells.
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7. General Metabolism . Published sources indicate methyl bromide Is
rapidly absorbed via the lungs. Additional testing is not needed
at this time, but may be requested depending on the evaluation
of dietary, chronic toxicology and worker exposure data.
8. Ecological Effects . No toxicity data are available on non—target
organisms. Due to the highly toxic nature of methyl bromide to
humans, it is expected to be toxic to birds, fish, and wildlife.
However, little hazard to nontarget organisms is expected
for all indoor and most outdoor uses of methyl bromide. The
practice of covering a treated area with a tarpaulin following
soil injection minimizes exposure to nontarget organisms
following outdoor uses. Because surface waters may receive
input from ground water, the need for acute testing on freshwater
fish and aquatic invertebrates will depend on the determination
of methyl bromide’s potential to reach ground water. Preliminary
ground water monitoring data showed no detectable levels
(the level of detection was 1 ppb). No oral or dietary
testing on birds is required because methyl bromide is a
gaseous formulation.
9. Environmental Fate . Methyl bromide is not expected to reach
surface water because most outdoor uses are soil injected.
Methyl bromide’s potential to reach ground water is unknown,
but based on its chemical structure, solubility and use
patterns, it has been identified as having the potential to
enter ground water. The Agency issued a data call—in notice
on March 8, 1984 requesting product chemistry data and a
data call—In notice on May 16, 1984 requestIng environmental
fate data. Hydrolysis data indicate methyl bromide breaks
down at a rate of 1.4 mg /liter water/day at 25°C to principally
methanol and inorganic bromide. Soil metabolism, leaching
and adsorption/desorption and soil dissipation data have
been received by the Agency and are currently under review.
A photodegradation study in water is required. Based on
these data, the Agency will evaluate methyl bromide’s potential
for contaminating ground water. Because the Agency is unable
to determine if residues exist in primary treated crops,
rotational crop data are reserved. If residues of concern are
found in the primary treated crops, rotational crop data will
be required.
D. TOLERANCE REASSESSMENT
Tolerances have been established (40 CFR 180.123) for residues
of inorganic bromide in raw agricultural commodities which have
been fumigated postharvest with methyl bromide.
Tolerances have been established (40 CFR 180.199) for
residues of inorganic bromides resulting from soil treatment
with conibinations of chloropicrin and methyl bromide.
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According to 40 CFR 180.3 (c)(1) •Where tolerances for
inorganic bromide in or on the same raw agricultural commodity
are set in two or more sections in this part, the overall quantity
of inorganic bromide to be tolerated from use of two or more
pesticide chemicals for which tolerances are established is
the highest of the separate applicable tolerances.”
According to 40 CFR 180.3(c)(2) tolerances are established
in terms of inorganic bromide residues “based on evidence of the
dissipation of the organic pesticide or its conversion to
Inorganic bromide residues in the food when ready to eat,”
and therefore, methyl bromide per se is exempt from a require-
ment for tolerance.
Tolerances have been established for residues of inorganic
bromide in milled fractions resulting from fumigation of grain—
mill machinery (21 CFR 193.225), and for residues of inorganic
bromide in processed grains used in fermented malt beverages
(21 CFR 193.230). Food additive tolerances have been established
for residues of inorganic bromide in fumigated processed foods
(21 CFR 193.250). Feed additive tolerances have been established
for residues of Inorganic bromide in fumigated animal feeds
(21 CFR 561.260).
The Agency evaluated the residue and toxicology data
supporting these tolerances, and reviewed all uses of methyl
bromide. Based on the available data, the following conclusions
have been made.
o Because residues of methyl bromide p se have been found
in foods, the establishment of tolerances in terms of
inorganic bromide residues alone is not adequate. Data
concerning the residues of methyl bromide se have
been or are required.
o The metabolism of methyl bromide in plants is not adequately
understood, and plant metabolism studies are required.
o None of the inorganic bromide tolerances in or on raw
agricultural commodities (RACs) or processed products
is supported due to the inadequacy of available data.
Data are required for each registered RAC and processed
product depicting the residues of concern resulting
from application. If both preplarit and stored commodity
fumigations are registered uses on a given commodity,
then data are required depicting both inorganic bromide
and methyl bromide per se residues resulting from the
combination of the two types of treatment, and one tolerance
will be established.
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o The metabolism of methyl bromide in animals is not adequately
understood. However, no animal metabolism studies will
be required unless the plant metabolism or residue studies
indicate the presence of residues of concern in feed items.
o No conclusions can be reached at this time as to the magnitude
of residues of methyl bromide in animal products because the
magnitude of residues in feed items, metabolism in plants and
(if required) metabolism in animals are not adequately defined.
Upon receipt of these data, the necessity of tolerances in
animal products will be determined.
o Plant metabolism data must be developed first to identify
the residues of concern. Residue data will then be required
showing the magnitude of the residues of concern in or on
treated foods or feeds. If plant metabolism or residue
studies indicate the presence of residues of concern in
feed items, animal metabolism and livestock feeding
studies will be required.
An Acceptable Daily Intake (ADI) for inorganic bromide
set by FAO/WHO is 1.0 mg/kg/day. A similar ADI (1.1 mg/kg/day)
set by FDA in 1961 is used by the Agency. The ADI set by FDA
is based on information derived from human use of inorganic
bromide therapeautic drugs showing that 11 mg/kg/day inorganic
bromide is a safe level provided that the person is not unduely
sensitive to inorganic bromide. A 10—fold safety factor is
used to allow for human sensitivity. Based on the available
reviews of laboratory animal data and human use as a therapeutic
drug, no further data are requested on inorganic bromide.
The Theoretical Maximum Residue Concentration (TMRC) for
inorganic bromide resulting from treatment with methyl bromide
is 0.42 mg/kg/day. This utilizes approximately 38% of the
ADI of Inorganic bromide.
Because no chronic and reproduction studies are available,
an ADI has not been set for methyl bromide Se. When
toxicological data are received, an ADI will be established.
Based on requested residue and toxicology data a tolerance
reassessment will be performed.
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IV. REGULATORY POSITION AND RATIONALE
A. REGULATORY POSITIONS
Based on review and evaluation of all available data
on methyl bromide, the Agency has made the following determinations.
Refer to Section IV.D for specific language for label revisions.
1. The Agency considered whether methyl bromide met one of
the criteria for Special Review, that of acute toxicity to
humans, and determined it will not be placed in the Special
Review process at this time. The Agency is requiring extensive
additional protective measures to reduce worker risks. The
Agency will evaluate the effectiveness of these measures by
examining pesticide poisoning incidence reports to determine
if additional regulatory action is necessary to reduce the
risk from methyl bromide exposure.
Rationale : The Agency is very concerned about the high acute
toxicity of methyl bromide, and the serious poisoning incidents
that have been reported. However, a review of the occupational
poisoning data from the State of California indicates circumstances
leading to overexposures can be attributed primarily to
inadequate employee training or supervision, carelessness,
or equipment failure. The Agency believes additional protective
measures can be taken to reduce worker risks during all types of
fumigation. These measures include adding chioropicrin as a
warning agent, restricted use-classification of 1.5 lb containers
or less that are currently unclassified, extensive label revisions,
and the inclusion of an application manual for all methyl
bromide products covering the safe use of the product (these
measures are discussed in detail in Regulatory Position and
Rationale 2, 3 and 4, and B. Criteria for Registration).
The Agency believes the measures required in PR Notice 85—6
will also reduce worker risks during fumigation of enclosed spaces.
The Agency believes these measures will substantially reduce
acute risks to users and that a Special Review is not necessary
at this time. The Agency will monitor incident data to determine
if exposure is being significantly reduced.
2. The Agency is requiring that chloropicrin at a concentra-
tion between 0.25% and 2.0% be present as a warning agent in
methyl bromide formulations used for all outdoor sites including
soil fumigation and for fumigation in enclosed spaces, except
for commodity fumigation. The Agency is requiring that
chioropicrin at these levels be listed as an inert ingredient,
and that the label state it has been added as a warning agent.
Rationale : Many methyl bromide products contain chloropicrin as
a warning agent because methyl bromide is odorless and a
worker may be unaware of being exposed to hazardous levels.
However, there are existing registrations for 100% formulated
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methyl bromide products. The use of chioropicrin with its
ability to cause painful irritation to the eyes, producing
tearing, and its disagreeable pungent odor at low concentrations
will warn a person of methyl bromide exposure and will promote
its safe use. The Agency is not requiring that chioropicrin
be added to commodity fumigation uses because there is a
possibility that residues of chioropicrin remain in treated
products, and no tolerances for chloropicrin have been established.
Registrants whose products require the addition of chloro
picrin must submit applications for amended registrations. At the
level of 2% or less, chioropicrin adds no additional efficacy to
the formulation and, therefore may be classified as an inert
ingredient (currently, some products list chloropicrin at a
level of 2% or less as an active ingredient).
3. The Agency will require all products containing methyl
bromide to be classified for restricted use. The Agency will
propose to amend 40 CFR 162.31 (proposed §152.171, 49 FR
37946—37949) to require restricted use classification for
1.5 lb containers or less of methyl bromide containing chioropicrin
as a warning agent. Methyl bromide products that are restricted
according to 40 CFR 162.31 will continue to be classified for
restricted use.
Rationale : In 40 CFR 162.31, the Agency restricted all methyl
bromide formulations in containers greater than 1.5 lbs and
containers with not more than 1.5 lbs having no indicator.
Containers of 1.5 lbs or less with 0.25% to 2.0% chioropicrin
as a warning agent that are used for nondomestic single
applications for soil treatment in closed systems are unclassified
according to 40 CFR 162.31. The Agency believes restricted
use classification of all methyl bromide products is necessary
to protect users from the acute toxic effects of methyl
bromide. The registrations of the currently unclassified
methyl bromide products must be amended to require restricted
use classification and the Agency will amend its regulation
accordingly.
4. The Agency will require that application manuals be developed
by registrants to provide the necessary details for the safe
use of methyl bromide fumigants. Such manuals will be considered
part of the registered labeling and will be required to be
submitted within 90 days from the date of receipt of this
standard for approval by the Agency.
Rationale : Because of the limitations of space on labels and
the complexity of the precautions necessary to use methyl
bromide safely, an application manual is needed to provide
an adequate description of the various use patterns and the
special precautions applicable to each. The manual should
provide, but need not be limited to, Information on the chemical
and physical properties of the formulation, and should include
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instructions for the care and use of respiratory equipment,
equipment maintenance, pre—fumigation inspections and/or
testing, detector device usage, posting, aeration techniques,
and instructions to comply with all local regulations and
ordinances on fumigants.
5. The Agency will continue to require that enclosed spaces
fumigated with methyl bromide be aerated until the level of
methyl bromide is below 5 ppm. Entry by any person into the
treated areas before this level is reached is not allowed
unless the person is provided with an approved respiratory
protection device (SCBA or combination air—supplied/SCBA).
Rationale : The interim 5 ppm reentry level was established under
the Label Improvement Program for Fumigants, PR Notice 85—6,
August 30, 1985 because the Agency is concerned about the
possible inhalation exposure of workers handling methyl
bromide because of its high acute toxicity. To better eval-
uate the worker risk, the Agency issued a Special Data Call—In
Notice under FIFRA §3(c)(2)(B) requesting applicator exposure
data. This notice originally requested data for dermal and
inhalation exposure. The Agency waived the requirement for
dermal exposure data because methyl bromide fumigation is
done in a closed system, and inhalation is the most important
route of exposure even during a spill. The inhalation exposure
data were received by the Agency in July 1986 and are currently
under review. As soon as these data and the toxicology data
required in Table A are submitted and reviewed, the Agency
will reevaluate the reentry level.
6. The Agency will not require respiratory equipment to be
worn during routine soil fumigation, but will require that such
equipment be on the premises in case of an emergency situation.
Rationale : Based on all available data, the Agency has determined
that under normal conditions of use the concentration in the
working area will not generally exceed 5 ppm as a time weighted
average and no respiratory protection is required. However,
there is the possibility of a spill or leak during soil funiiga—
tion. Therefore, a SCBA or a combination alr—supplied/SCBA
respirator must be available and will be required for entry
into an affected area in the event of a leak or spill.
7. The Agency will not impose a special label advisory statement
for endangered species at this time.
Rationale : The Agency does not expect exposure to endangered
species. If data indicate methyl bromide may reach surface
water, acute aquatic toxicity studies will be required. If
the estimated environmental concentrations of methyl bromide
exceed the endangered species trigger for aquatic species
(1/10 of the LC 50 ), an Office of Endangered Species opinion
will be requested.
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8. The Agency will not allow any significant new food uses (an
increase in the Theoretical Maximum Residue Contribution of
greater than one percent) to be established for methyl bromide
until the toxicological and residue chemistry data deficiencies
identified in Table A have been satisfied.
Rationale : The Agency is unable to complete a tolerance
reassessment of methyl bromide because of extensive residue
chemistry atid toxicology data gaps. The data requested in
Table A are :needed for the Agency to calculate an ADI for
methyl bromlde and its metabolites and to reassess the current
tolerances.
9. The Agency is requiring residue data to support the existing
tolerances for use in or on cumin seed, mangoes, papayas and
pomegranates for which no registered uses can be located.
If no data developer can be located, the tolerances may be
revoked.
Rationale : Tolerances have been established for these crops
in terms of inorganic bromide. However, residue data do
not exist to support these uses. Also, the Agency is unable to
locate registered uses for these crops. The Agency is aware that
these tolerances are for imported products, however, data must
be submitted to support the tolerances.
10. The Agency is requiring the submission of residue chemistry
data to support all current inorganic bromide tolerances
relating to the use of methyl bromide (see 40 CFR 180.123,
180.199 and 180.3(c)(1) as well as 21 CFR 193.225, 193.230,
193.250 and 561.260) and to establish tolerances for methyl
bromide per Se. Plant metabolism data along with storage
stability data should be developed first followed by the
residue data on crops. Animal metabolism data and livestock
feeding studies are reserved pending results of the above
data. Finally, if residues of concern, including at a minimum
inorganic bromide and methyl bromide per se, are found in
animals as a result of ingesting methyl bromide treated feeds,
tolerances will be required for animal products and byproducts,
eggs, and milk.
Rationale : None of the methyl bromide tolerances are supported
due to the inadequacy of the available data (see Section lIt. D
Tolerance Reassessment). Plant metabolism data must be developed
first to identify the residues of concern. Residue data will then
be required showing the magnitude of the residues of concern
in or on treated foods or feeds. If plant metabolism or
residue studies indicate the presence of residues of concern
in feed items, animal metabolism and livestock feeding studies
will be required.
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11. No crop group tolerances, as specified under 40 CFR 180.34(f),
may be established at this time.
Rationale : As noted in position 10, none of the current methyl
been established for methyl bromide per se. Therefore, no group
tolerances can be set. The registrants may propose crop group
tolerances. When appropriate data required in Table A are
submitted and evaluated, crop group tolerances may be set.
12. The Agency will propose that 40 CFR 180.3(c)(2) be deleted,
and will propose tolerances for methyl bromide per se.
Rationale : Tolerances for brominated organic fumigants such as
methyl bromide concurrent with inorganic bromide tolerances were
thought unnecessary since the parent compound was expected to
degrade completely and/or dissipate by the time the food item
was consumed. However, due to findings of methyl bromide per se
in foods treated post—harvest, the Agency will require tolerances
for methyl bromide per se.
13. As soon as the required inorganic bromide residue data have
been submitted and evaluated, the Agency will consider deleting
all existing paragraphs in the 21 and 40 CFR concerning inorganic
bromide tolerances and replacing them with a single paragraph
for raw agricultural commodities (RACs) (40 CFR 180) and
processed products (21 CFR 193 and 561). One inorganic
bromide level for each RAC or processed food or feed would
be substituted. Pesticides/sources which are covered by the
tolerances would be identified. Any tolerance for inorganic
bromide must be high enough to cover naturally occurring
inorganic bromide plus inorganic bromide resulting from soil
and/or postharvest fumigation.
Rationale : Inorganic bromide is a naturally occurring substance
and is also a metabolite of numerous pesticides. The Agency
policy has been to set inorganic bromide tolerances whenever
significant levels of inorganic bromide could result from the
use of a pesticide. This policy has resulted in a proliferation
of tolerances for inorganic bromide. As described in 40 CFR
180.3(c)(1), whenever more than one inorganic bromide tolerance
exists for a single commodity, then the enforcement limit is
the highest tolerance for that commodity. Thus the only
regulatory limit used for enforcement of inorganic bromide
residues on a given commodity is the highest existing tolerance.
The proposed deletion of all but the highest inorganic bromide
tolerance for a commodity will merely clarify what actually
occurs in practice, i.e., the highest tolerance for a commodity
is the regulatory limit. The only effect of this change from
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a regulatory standpoint is to replace multiple CFR sections
on inorganic bromide tolerances with one section. It would not
affect enforcement procedures or residue chemistry data require-
ments.
If a new pesticide use results in residues of inorganic
bromide, then under the current system a new inorganic bromide
tolerance has to be established in yet another section in
40 CFR 180. Under the proposed scheme the only change in
the CFR would be that the name-of the chemical is added to
the section in 40 CFR 180 for inorganic bromide residues. Only
if the new use results in higher residues of inorganic bromide
than any registered use would the numeric tolerance for
inorganic bromide be changed.
Tolerances for the parent compound would need to be set
in most cases. The 40 CFR 180 section containing the tolerances
for the parent compound should contain a reference to the
existence of the tolerances for the inorganic bromide metabolite.
14. While data gaps are being filled, currently registered
manufacturing use products (MPs) and end—use products (EPs)
containing methyl bromide may be sold, distributed, formulated
arid used, subject to the terms and conditions specified in
this Standard. Registrants must provide or agree to develop
additional data, as specified in the Data Appendices, in
order to maintain existing registrations.
Rationale : Under FIFRA, the Agency does not normally cancel or
withhold registration for previously registered use patterns
simply because data are missing or are inadequate (see FIFRA
sec. 3(c)(2)(B) and 3(C)(7). Issuance of this Standard provides
a mechanism for identifying data needs which then will be
required to be submitted to maintain the registration of
pesticide products containing methyl bromide. These data will
be reviewed and evaluated, after which the Agency will determine
if additional regulatory changes are necessary.
B. Criteria for Registration
To be registered or reregistered under this Standard,
products must contain methyl bromide as the sole active
ingredient*, bear required labeling, and conform to the product
composition, acute toxicity limits, and use pattern require-
ments listed in this section.
*1 The Agency has determined that chloropicrin in amounts of
2% or less is present solely as a warning agent and must
be declared as inert in formulations of 98% to 99.75%
methyl bromide. See Section IV(A)(2).
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C. Acceptable Ranges and Limits
1. Product Composition Standard
To be registered or reregistered under this Standard,
manufacturing—use products (MPs) must contain methyl bromide
as the sole active ingredient. Each MP formulation proposed
for registration must be fully described with an appropriate
certification of limits, stating maximum and minimum amounts
of the active ingredient and inert ingredients which are
present in products, as well as Impurities found at greater
than 0.1%.
2. Acute Toxicity Limits
The Agency will consider registration of technical
grade and manufacturing—use products containing methyl
bromide provided that the product labeling bears appropriate
precautionary statements for the acute toxicity category in
which each product is placed.
3. Use Patterns
To be registered under this Standard, manufacturing—use
products may be labeled for formulation into end—use products
only for the use patterns listed below. The EPA Index to
Pesticide Chemicals lists all registered uses, as well as
approved maximum application rates and frequencies.
o Terrestrial, domestic, food uses on :
asparagus; broccoli; cauliflower; citrus fruits;
deciduous fruit trees (including apple; apricot;
cherry and peach); eggplant; grapes; lettuce;
melons; nut crops; nut trees; onions (direct seeded);
peppers; pineapple; strawberry; tomato
o TerrestrIal, domestic, non—food uses on :
bulk soil (potting soil, top soil); compost
piles; forest tree transplants; manure; mulch
(hay, manure, straw); ornamental lawns;
ornamental plants (including nursery stock);
ornamental turf; recreational areas (Including
athletic fields; golf courses and parks); seed
and transplant beds (nonfood); tobacco
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o Domestic outdoor use on :
domestic dwellings (outdoor); wooden plant stakes
o Greenhouse, food uses on :
tomato
o Greenhouse, non—food uses on :
nonfood/nortfeed crops
o Indoor
— Fumigation of stored agricultural commodities use on :
alfalfa (hay); almond; apple; apricot; artichoke
(Jerusalem); barley; beans; beets (roots); Brazil nut;
butternut; cabbage; cantaloupe; carrots; cashew;
cherry; chestnut; citron; cocoa beans; corn; corn
(sweet); cotton (including baled cotton); cottonseed;
cucumber; eggplant; filbert (hazelnut); garlic;
grapefruit; grapes; honeydew melon; horseradish (roots);
kumquat; lemon; lime; macadamia nut (bushnut); muskmelon;
nectarine; oats; okra; onion; onion (cipollini bulbs);
orange; parsnip (roots); peach; peanuts; pear; peas;
pecan; peppers; pimento; pineapple; pistachio; plum;
popcorn; potato; prune; pumpkin; quince; radish;
rice; rutabaga; rye; salsify (roots); sorghum; squash
(summer); squash (winter) squash (zucchini); sugar beets;
sweet potato; tangelo; tangerine; tobacco; tomato;
turnip (roots); walnut; watermelon; wheat; yams
o Indoor
— Fumigation of processed food/feed use on :
candy (processed); cereals (processed); cheese; cheese
byproducts; copra; dog feed; eggs (dried); flour
(including bagged cereal flour; bakery mixes and
cereal flour); feed/food containers (empty) (including
bags, boxes and crates); food processing, handling and
storage areas; fruits (dried) (including apple; apricot;
cherry; date; fig; peach; pear; prune and raisin); grain
bins (empty); grain products (processed); herbs;
seasoning or spices (dried); meat processing plants
(including ham houses); meat products (including
cured meat products)
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o Indoor
— Non—food use on :
Airtight chambers (empty) (including atmospheric chambers,
vacuum chambers, and fumigation vaults); barns; boxcars!
railway cars (empty); burlap bags (empty); domestic
dwellings (including garages); domestic dwelling
contents (including furniture); farm storage areas;
greenhouse (empty); lumber and wood products; mushroom
houses (empty); nonfeed/nonfood containers (empty)
(including bags, boxes and crates); paper (stored);
poultry houses (empty); ships (cargo)/steel barges;
tarpaulins; trailers (empty); van containers (empty)
D. Required Labeling
All manufacturing—use products and end—use products
must bear appropriate labeling as specified in 40 CFR 162.10.
Appendix II contains information on label requirements. Submit
labels and product manuals within 90 days from the date of
receipt of this standard for review and approval.
No pesticide product containing methyl bromide may be
released for shipment by the registrant after nine months
from the date of receipt of this standard unless the product
bears an amended label, including the product manual, which
complies with the requirements of this standard.
No pesticide product containing methyl bromide may be
distributed, sold, offered for sale, held for sale, shipped,
delivered for shipment, or received and (having so received)
delivered or offered to be delivered by any person in channels
of trade after 12 months from the date of receipt of this
standard unless the product bears an amended label, including
the product manual, which complies with the requirements of
this Standard.
In addition to the above, the following information must
appear on the labeling:
1. Ingredient Statement
The ingredient statement for Manufacturing—Use Products must
list the active ingredient as:
Methyl Bromide
2. Use Pattern Statements
All manufacturing—use products must state that they are
intended for formulation into end—use products for acceptable
use patterns. Labeling for manufacturing—use products must
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specify sites which may appear on the labels of end—use products
formulated from them and which are listed in Use Patterns ,
Section C.3. No use may be included on the label where the
registrant fails to agree to comply with the data requirements
in Table A for that use pattern.
3. Precautionary Statements for Manufacturing—Use Products
a. Labels for manfacturing—use methyl bromide products
must bear statements reflecting that methyl bromide
is highly acutely toxic. Required precautionary
statements associated with this category are
specified in 40 CFR 162.10.
b. The signal word “DANGER along with the word •POISOW
in red and the skull and crossbones symbol are
required on the front panel of all manufacturing—use
labels.
c. The following revised environmental hazard state-
ments must appear on all manufacturing—use labels:
This pesticide is toxic to wildlife. Do not
discharge effluent containing this product into
lakes, streams, ponds, estuaries, oceans, or
public waters unless this product is specifically
identified and addressed in an NPDES permit. Do
not discharge effluent containing this product to
sewer systems without previously notifying the
sewage treatment plant authority. For guidance
contact your State Water Board or Regional Office
of the EPA.
4. Precautionary Statements for End—Use Products
a. All end—use products must bear the restricted—use
s t a t e men t:
RESTRICTED USE PESTICIDE
DUE TO ACUTE TOXICITY
For retail sale to and use only by certified
applicators or persons under their direct
supervision, and only for those uses covered
by the certified applicator’s certification.
b. The following Spanish warning statement must be
located on the front panel of all end—use products:
PRECAUTION AL USUARIO: Si usted no lee Ingles,
no use este producto hasta que la etiqueta le
haya sido explicada ampliamente.
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c. The English and Spanish signal words DANGER” and
“PELICRO” along with the word ‘POISON” in red and
the skull and crossbones symbol are required on
the front panels of all end—use products.
d. The following human hazard precautionary statements
must appear on the front or side panel under the
heading “Hazards to Humans” and in the application
manual of all end—use products:
DANGER
Extremely hazardous liquid and vapor under
pressure. Do not breathe vapor. Inhalation
may be fatal or cause serious acute illness
or delayed lung or nervous system injury.
Liquid or vapor can cause serious skin or
eye injury which may have a delayed onset.
Do not get liquid on skin, in eyes or on
clothing.
[ If the product is 100% methyl bromide).
Methyl bromide vapor is odorless and non—
irritating to skin and eyes during exposure.
Exposure to toxic levels may occur without
warning or detection by the user.
[ If the product contains chloropricrin as a
warning indicator (at levels of 2% or less)].
This product contains chloropicrin as a warning
odorant. Chloropicrin may be irritating to the
upper respiratory tract, and even at low levels
can cause painful irritation to the eyes,
producing tearing. If these symptoms occur,
leave the fumigation area immediately.
e. The following practical treatment statements must
appear on the front panel and in the application
manual of all end—use products:
In all cases of overexposure, get medical
attention immediately. Take person to a
doctor or emergency treatment facility.
If inhaled : Get exposed persons to fresh air.
Keep warm. Make sure person can breathe
freely. If breathing has stopped, apply
artificial respiration. Do not give anything
by mouth to an unconscious person.
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If on skin : Immediately remove contaminated
clothing, shoes, and any other item on skin.
Wash contaminated skin area thoroughly with
soap and water.
If in eyes : Hold eyelids open and flush with a
steady, gentle stream of water for at least
15 minutes.
f. The following Note to Physician” must be located
with the human hazard statements, but in a separate
paragraph, on the label, and in the application
manual of all end—use products:
Early symptoms of overexposure are dizziness,
headache, nausea and vomiting, weakness and
collapse. Lung edema may develop in 2 to 48
hours after exposure, accompanied by cardiac
irregularities; these effects are the usual
cause of death. Repeated overexposures can
result in blurred vision, staggering gait and
mental imbalance, with probable recovery after
a period of no exposure. Blood bromide levels
suggest the occurrence, but not the degree,
of exposure. Treatment is symptomatic.
g. The following specific use directions must appear
on the label for all end—use products:
This fumigant is a highly hazardous material
and should be used only by individuals trained
in its proper use. Before using, read and
follow all label precautions and directions,
including the attached product manual.
All persons working with this fumigant must be
knowledgeable about the hazards, and trained in
the use of required respirator equipment and
detector devices, emergency procedures, and
proper use of the fumigant.
[ specific directions for use follow]
h. The following protective clothing statements must
appear on the label for all end—use products:
Wear loose cotton long sleeve shirts and pants,
shoes and socks that are cleaned after each
wearing. Do not wear jewelry, gloves or boots
when handling. Methyl bromide is heavier
than air and may be trapped inside clothing
and cause skin injury. If full—face respiratory
protection is not required, wear goggles or
full face shield for eye protection when
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handling liquid. After application, immediately
remove clothing, shoes and socks. Do not reuse
contaminated clothing or shoes until cleaned.
Drenched clothing cannot be adequately
decontaminated.
i. The following storage and handling statements must
appear on the labeling for all end—use products:
Store in dry, cool, well—ventilated area under
lock and key. Post as a pesticide storage area.
Do not contaminate water, food or feed by storage.
Store cylinders upright, secured to a rack or
wall to prevent tipping. Cylinders should not
be subjected to rough handling or mechanical
shock such as dropping, bumping, dragging,
or sliding. Do not use rope slings, hooks,
tongs, or similar devices to unload cylinders.
Transport cylinders using hand truck, fork
truck or other device to which the cylinder
can be firmly secured.
Do not remove valve protection bonnet and
safety cap until immediately before use.
Replace safety cap and valve protection
bonnet when cylinder is not in use.
When cylinder is empty, close valve, screw
safety cap onto valve outlet, and replace
protection bonnet before returning to shipper.
Only the registrant is authorized to refill
cylinders. Do not use cylinders for any
other purpose. Follow registrant’s instructions
for return of empty or partially empty cylinders.
j. The following pesticide disposal statement must
appear on the labeling for all end use products:
Pesticide wastes are toxic. Improper disposal
of excess pesticide is a violation of Federal
law. If these wastes cannot be disposed of
by use according to label instructions,
contact your State Pesticide or Environmental
Control Agency, or the Hazardous Waste
representative at the nearest EPA Regional
Office for guidance.
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5. Precautionary Statements for End—Use Products Intended
for Structural, Transportation, Space or Commodity
Fumigation
a. In addition to the use directions specified under
Section 4 above, the following statements must appear
on all end—use products intended for structural,
transportation, space or commodity fumigation:
When used for fumigation of enclosed spaces,
[ houses and other structures, warehouses,
grain bins or elevators, vaults, chambers,
greenhouses, trucks, vans, boxcars, ships,
and other transport vehicles, and tarpaulin—
covered areas or commodities], two persons
trained in the use of this product must
be present during introduction of the fumigant,
initiation of aeration, and after aeration when
testing for reentry. Two persons do not need
to be present if monitoring is conducted
remotely (outside the area being fumigated).
Do not fumigate with this product when
commodity temperature is below 40°F.
[ Specific directions for use follow. The
registrant must provide complete directions
for use of the product for fumigation of
specified spaces, commodities, or structures].
b. The following placarding statements are required
for all end—use products intended for structural,
transportation, space, or commodity fumigation:
The applicator must placard or post all entrances
to the fumigated area with signs bearing, in
English and Spanish:
1. The signal word DANCER/PELIGRO and the skull
and crossbones symbol.
2. The statement, “Area under fumigation, DO NOT
ENTER/NO ENTRE.
3. The date of fumigation.
4. Name of fumigant used.
5. Name, address, and telephone number of the
applicator.
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Only a certified applicator or someone under
his/her supervision may remove placards, and only
when the concentration of methyl bromide in the
treated site or commodity is below 5 ppm.
Any person who transfers a treated commodity to
another site without aeration must ensure that
the new site is placarded until the commodity is
aerated below the threshold concentration.
c. The following respiratory protection statements
must appear on the labeling for all end—use products
intended for structural, transportation, space, or
commodity fumigation:
“If the concentration of methyl bromide in the
working area, as measured by [ a direct—reading
detector device], does not exceed 5 ppm
(20 tng/M 3 ), no respiratory protection is
required.” [ The registrant must identify one
or more detector devices suitable for use
with the product and provide or reference
instructions on Its use].
If this concentration is exceeded at any time,
all persons in the fumigation area must wear
protective clothing and a [ NIOSH! MSHA approved
self—contained breathing apparatus (SCBA) or
combination air—supplied/SCBA respirator].
[ The registrant may instead identify a specific
respiratory protection device to be used
with the product].
d. The following aeration and reentry statements must
appear on the labeling for all end—use products
intended for structural, transportation, space, or
commodity fumigation:
After fumigation, treated areas must be aerated
until the level of methyl bromide is below 5 ppm.
Do not allow entry into the treated area by any
person before this time unless protective clothing
and a respiratory protection device (SCBA or
combination air—supplied/SCBA) is worn.
e. The following spill and leak procedures must appear
on the labeling for all end—use products intended
for structural, transportation, space, or commodity
fumigation:
Evacuate immediate area of spill or leak. Use
SCBA or combination air—supplied/SCBA respirator
for entry into affected area to correct problem.
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Move leaking or damaged cylinders or containers
outdoors or to an Isolated location, observing
strict safety precautions. Work upwind if
possible. Allow spill to evaporate. Do not
permit entry Into spill area by unprotected
persons until concentration of methyl bromide
is determined to be less than 5 ppm.
Contaminated soil, water, and other cleanup
debris is a toxic hazardous waste. Report
spill to the National Response Center
(800—424—8802) if the reportable quantity of
1000 lbs. is exceeded.
6. Precautionary Statements for End—Use Products
Intended for Soil Fumigation
a. The following precautions to be followed prior to
fumigation must appear on the label or in the
application manual for all end—use products
intended for soil fumigation:
Comply with all local regulations and ordinances.
Obtain an application permit from Agricultural
Regulatory Agencies as required.
Never fumigate alone. It is imperative always to
have an assistant and proper protective equipment
in case of accidents.
Drivers of application equipment must advise
other workers of all precautions and procedures.
In addition, drivers must instruct their helpers
in the mechanical operation of the tractor and
how to safely work with the tractor and driver
while fumigating.
Handle this fumigant in the open, with the operator
“up wind” from the container where there is good
ventilation.
Check fumigant pressure system for leaks before
beginning operation.
Two trained persons must be present during
introduction of the fumigant.
When fumigating soil from a tractor, 5 gallons
of water must be carried on the tractor and
placed where it is readily accessible. In
addition to water available on the tractor,
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at least 5 gallons additional water must be
available from the service truck. This
water must be potable and in containers
marked “Decontamination water not
to be used for drinking.”
All trash should be cleared from the field
before starting fumigation.
b. The following precautions to be followed during
fumigation must appear on the label or In the
application manual for all end—use products
intended for soil fumigation:
This fumigant should not be applied when there
is an atmospheric inversion. Since uncomfortable
concentrations of chloropicrin may drift to
nearby areas, immediately cover treated area
with plastic tarpaulin for a minimum of 48 hours.
Do not lift injection shanks to turn at the end
of a pass until fumigant has drained from system
following closure of shutoff valve.
If trash is inadvertently pulled by the shanks
to the ends of the field when fumigating, it
must be covered by lifting the shanks, then
covering the trash with polyethylene film
before making the turn for the next pass.
When changing the cylinders, be certain they
are turned off and fumigant system is not
under pressure.
c. The following precautions to be followed after
fumigation must appear on the label or In the
application manual for all end—use products
intended for soil fumigation:
Post all treated areas with warning signs.
Keep all animals, children and unauthorized
people away from area under fumigation for
48 hours after fumigation and during removal
of tarpaulin.
Two trained persons must be present during
removal of the tarpaulin.
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d. The following spill and leak procedures must appear
on the label or in the application manual for all
all end—use products intended for soil fumigation:
In case of a rupture of hose or fitting while
applying fumigant, immediately stop tractor
and motor. Evacuate immediate area of spill or
leak. Use SCBA or combination air—supplied/SCBA
respirator for entry into affected area to
correct problem. Approach from upwind to
make necessary repairs. Do not reenter area
without respiratory protection until a spill
has evaporated or a leak has been fixed.
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V. PRODUCTS SUBJECT TO THIS STANDARD
All products containing methyl bromide are subject to
certain requirements for data submission or changes in
composition, labeling or packaging of the product. The
applicable requirements depend on whether the product is a
manufacturing or end use product and whether the pesticide
is the sole active Ingredient or one of multiple active
ingredients.
Products are subject to this Registration Standard as
follows:
A. Manufacturing use products containing methyl bromide as
the sole active ingredient are subject to:
1. The restrictions (if any) upon use, composition, or
packaging listed in Section IV, if they pertain to the
manufacturing use product.
2. The data requirements listed in Tables A and B 2
3. The labeling requirements specified for manufacturing
use products in Section IV.
4. Administrative requirements (application forms, Confiden-
tial Statement of Formula, data compensation provisions)
associated with reregistration.
2 Data requirements are listed in the two Tables in
Appendix I of this Registration Standard. The Guide to
Tables in that Appendix explains how to read the Tables.
Table A lists generic data requirements applicable to all
products containing methyl bromide Table B lists product—
specific data applicable to manufacturing use products. The
data in Tables A and B need not be submitted by a producer
who is eligible for the formulatorVs exemption for methyl
bromide.
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-------
B. Manufacturing use products containing methyl bromide in
combination with other active ingredients are subject to:
The data requirements listed in Table A.
C. End use products containing methyl bromide alone or in
combination with other active ingredients are subject to:
1. The restrictions (if any) upon use, composition, or
packaging listed in Section IV if they pertain to the
end use product.
2. If not eligible for the formulator’s exemption 3 , the
data requirements listed in Table A.
3. The labeling requirements specified for end use
products in Section IV.
3 If you purchase from another producer and use as the
source of your active ingredient only EPA—registered products,
you are eligible for the formulator’s exemption for generic
data concerning that active ingredient (Table A) and product—
specific data for the registered manufacturing use product
you purchase (Table B).
Two circumstances nullify this exemption:
1) If you change sources of active ingredient to an
unregistered product, formulate your own active ingredient,
or acquire your active ingredient from a firm with ownership
in common with yours, you lose the exemption and become
subject to the data requirements in Table A.
2) If no producer subject to the generic data requirements
in Table A agrees to submit the required data, all end use
producers lose the exemption, and become subject to those
data requirements.
—32—
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VI. REQUIREMENT FOR SUBMISSION OF GENERIC DATA
This portion of the Registration Standard is a notice
issued under the authority of FIFRA sec. 3(c)(2)(B). It
refers to the data listed in Table A, which are required to
be submitted by registrants to maintain in effect the regis-
tration of products containing this active ingredient. 4
A. What are generic data ?
Generic data pertain to the properties or effects of a
particular active Ingredient. Such data are relevant to an
evaluation of all products containing that active ingredient
regardless of whether the product contains other ingredients.
(unless the product bears labeling that would make the data
requirement inapplicable).
Generic data may also be data on a “typical formulation”
of a product. “Typical formulation” testing is often required
for ecological effects studies and applies to all products
having that formulation type. These are classed as generic
data, and are contained in Table A.
B. Who must submit generic data ?
All current registrants are responsible for submitting
generic data in response to a data request under FIFRA sec.
3(c)(2)(B) (DCI Notice). EPA has decided, however, not to
require a registrant who qualifies for the formulator’s
exemption (FIFRA sec. 3(c)(2)(D) and 152.85) to submit
generic data in response to a DCI notice if the registrant
who supplies the active ingredient in his product is complying
with the data request.
If you are not now eligible for a formulator’s exemption,
you may qualify for one if you change your source of supply
to a registered source that does not share ownership In
common with your firm. If you choose to change sources of
supply, the Confidential Statement of Formula must identify
the new source(s) and you must submit a Formulator’s Exemption
Statement form.
If you apply for a new registration for products containing
this active Ingredient after the issuance of this Registration
Standard, you will be required to submit or cite generic
data relevant to the uses of your product if, at the time
4 Registrations granted after issuance of this Standard
will be conditioned upon submission or citation of the data
listed in this Registration Standard.
—33—
-------
the application is submitted, the data have been submitted
to the Agency by current registrants. If the required data
have not yet been submitted, any new registration will be
conditioned upon the new registrant’s submission or citation
of the required data not later than the date upon which
current registrants of similar products are required to provide
such data. See FIFRA sec. 3(c)(7)(A). If you thereafter fail
to comply with the condition of that registration to provide
data, the registration may be cancelled (FIFRA sec. 6(e)).
C. What generic data must be submitted ?
You may determine which generic data you must submit by
consulting Table A. That table lists the generic data needed
to evaluate current uses of all products containing this
active ingredient, the uses for which such data are required,
and the dates by which the data must be submitted to the
Agency.
D. How to comply with DCI requirements .
Within 90 days of your receipt of this Registration
Standard, you must submit to EPA a completed copy of the form
entitled “FIFRA Section 3(c)(2)(B) Summary Sheet” (EPA Form
8580—1, enclosed) for each of your products. On that form
you must state which of the following six methods you will
use to comply with the DCI requirements:
1. You will submit the data yourself.
2. You have entered into an agreement with one or more
registrants to jointly develop (or share in the cost of
developing) the data , but will not be submitting the data
yourself. If you use this method, you must state who will
submit the data on which you will rely. You must also provide
EPA with documentary evidence that an agreement has been
formed which allows you to rely upon the data to be submitted.
Such evidence may be: (1) your letter offering to join In
an agreement and the other registrant’s acceptance of your
offer, (2) a written statement by the parties that an agreement
exists, or (3) a written statement by the person who will be
submitting the data that you may rely upon its submission.
The Agency will also require adequate assurance that the
person whom you state will provide the data is taking appropriate
steps to secure it. The agreement to produce the data need
not specify all of the terms of the final arrangement between
the parties or a mechanism to resolve the terms.
—34—
-------
3. You have attempted to enter into an agreement to
jointly develop data, but no other registrant has accepted
your offer. You request that EPA not suspend your registration
for non—compliance with the DCI . EPA has determined that,
as a general policy, it will not suspend the registration of
a product when the registrant has in good faith sought and
continues to seek to enter into a data development/cost
sharing program, but the other registrants developing the
data have refused to accept its offer. [ If your offer is
accepted, you may qualify for Option 2 above by entering
into an agreement to supply the data.]
In order to qualify for this method, you must:
1. File with EPA a completed “Certification of Attempt
to Enter into an Agreement with other Registrants for Develop-
ment of Data” (EPA Form 8580—6, enclosed).
2. Provide us with a copy of your offer to the other
registrant and proof of the other registrant’s receipt of your
offer (such as a certified mail receipt). Your offer must,
at a minimum, contain the following language or its equivalent:
[ Your company name] offers to share in the burden of
producing the data required pursuant to FIFRA sec.
3(c)(2)(B) in the [ name of active ingredient] Registration
Standard upon terms to be agreed or failing agreement
to be bound by binding arbitration as provided by FIFRA
section 3(c)(2)(B)(iii).
The remainder of your offer may not in any way attempt to
limit this commitment. If the other registrant to whom your
offer is made does not accept your offer, and if the other
registrant informs us on a DCI Summary Sheet that he will
develop and submit the data required under the DCI, then you
may qualify for this option. In order for you to avoid
suspension under this method, you may not later withdraw or
limit your offer to share in the burden of developing the
data. In addition, the other registrant must fulfill its
commitment to develop and submit the data.
4. You request a waiver of the data requirement . If
you believe that a data requirement does not (or should not)
apply to your product or its uses, you must provide EPA with
a statement of the reasons why you believe this is so. Your
statement must address the specific composition or use factors
that lead you to believe that a requirement does not apply.
Since the Agency has carefully considered the composition and
uses of pesticide products in determining that a data require-
ment applies, EPA does not anticipate that many waivers will
be granted. A request for waiver does not extend the time—
frames for developing required data, and if your waiver
request is denied, your registration may be suspended if you
fail to submit the data.
—35—
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5. You request that EPA amend your registration by deleting
the uses for which the data are needed . You are not required
to submit data for uses which are no longer on your label..
6. You request voluntary cancellation of the registration
of your product(s) for which the data are needed .
E. Procedures for requesting a change in testing protocol .
If you will generate the required data and plan to use
test procedures which deviate from (or are not specified in)
either EPA ’s Pesticide Assessment Guidelines or the Reports
of Expert Groups to the Chemicals Group, Organization for
Economic Cooperation and Development (OECD) Chemicals Testing
Programme, you must submit for EPA approval the protocols
you propose to use.
You should submit your protocols before beginning testing
and await EPA approval, because the Agency will not ordinarily
accept as sufficient studies using unapproved protocols.
A request for protocol approval will not extend the timeframe
for submission of the data, nor will extensions generally be
given to conduct studies due to submittal of inappropriate
protocols.
F. Procedures for requesting extensions of time .
If you think that you will need more time to generate
the data than is allowed by EPA’s schedule, you may submit a
request for an extension of time. Any request for a time
extension which is made as an initial response to a section
3(c)(2)(B) request notice must be submitted in writing to
the Product Manager listed at the end of this section and
must be made before the deadline for response. Once dates
have been committed to and EPA has accepted these commitments,
any subsequent requests for a time extension must be submitted
in writing to the Office of Compliance Monitoring.
EPA will view failure to request an extension before
the response deadline as a waiver of any future claim that
there was insufficient time to submit the data. While EPA
considers your request, you must strive to meet the deadline
for submitting the data.
The extension request should state the reasons why you
believe that an extension is necessary and the steps you
have taken to meet the testing deadline. Time extensions
normally will not be granted due to problems with laboratory
capacity or adequacy of funding, since the Agency believes
that with proper planning these can be overcome. Time extensions
may be considered when joint data development is planned,
—36—
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or when the Agency must approve a new or modified protocol
before the study can be begun.
A request for an extension does not extend the timeframe
for submission of the data. If EPA denies your request for
a time extension and you do not submit the data as requested,
EPA may begin proceedings to suspend the registrations of
your products.
G. Existing stocks provision upon suspension or cancellation .
The Agency has determined that if a registration is
suspended for failure to respond to a DCI request under
FIFRA sec. 3(c)(2)(B), an existing stocks provision is not
consistent with the Act. Accordingly, the Agency does not
anticipate granting permission to sell or distribute existing
stocks of suspended product except in rare circumstances.
If you believe that your product will be suspended or cancelled
and that an existing stocks provision should be granted, you
have the burden of clearly demonstrating to EPA that granting
such permission would be consistent with the Act. The following
information must be included in any request for an existing
stocks provision:
1. Explanation of why an existing stocks provision is
necessary, including a statement of the quantity of
existing stocks and your estimate of the time required
for their sale or distribution; and
2. Demonstration that such a provision would be consis-
tent with the provisions of FIFRA.
—37—
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VII. REQUIREMENT FOR SUBMISSION OF PRODUCT—SPECIFIC DATA
Under the authority of section 3(c)(2)(B) of FIFRA, EPA
has determined that certain product—specific data are required
to maintain your registrations in effect. Product—specific
data are derived from testing using a specific formulated
product, and, unlike generic data, generally support only
the registration of that product. All such data must be
submitted by the dates-specified in this Registration Standard.
If you have a manufacturing use product, these data are
listed in Table B. As noted earlier, the Agency has
decided that it will not routinely require product—specific
data for end use products at this time.
In order to comply with the product specific data require-
ments, you must follow the same procedures as for generic data.
See Section IV.D, E, F, and G. You should note, however, that
product chemistry data are required for every product, and the
only acceptable responses are options IV.D.1. (submit data)
or IV.D.6. (cancellation of registration).
Failure to comply with the product—specific data require-
ments for your products will result in suspension of the
product’s registration.
—38—
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VIII . REQUIREMENT FOR SUBMISSION OF REVISED LABELING
FIFRA requires each product to be labeled with accurate,
complete and sufficient instructions and precautions, reflecting
the Agency’s assessment of the data supporting the product
and its uses. General labeling requirements are set out in
40 CFR 162.10 (see Appendix II — LABELING and SUMMARY). In
addition, labeling requirements specific to products containing
methyl bromide are specified in Section IV.D of this Registra-
tion Standard. Applications submitted in response to this
notice must include draft labeling for Agency review.
If you fail to submit revised labeling as required,
which complies with 40 CFR 162.10 and the specific instructions
in Section IV.D., EPA may seek to cancel or suspend the
registration of your product under FIFRA sec. 6.
—39—
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IX. INSTRUCTIONS FOR SUBMISSION
A. Manufacturing Use Productq (MUPs) containing Methyl
Bromide as the sole active ingredient .
1. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division
for each product subject to this Registration Standard:
a. The “FIFRA Section 3(c)(2)(B)Summary Sheet” (EPA
Form 8580—1), with appropriate attachments. 5
b. Confidential Statement of Formula (EPA Form 8570—4).
c. Formulator’s Exemption Statement, if applicable.
d. Evidence of compliance with data compensation
requirements of FIFRA sec. 3(c)(1)(D). Refer to 40 CFR
152.80—152.99.
e. Three copies of draft labeling, including the
container label and any associated supplemental labeling.
Labeling should be either typewrittentext on 8—1/2 x 11
inch paper or a mockup of the labeling suitable for
storage in 8—1/2 x 11 files. The draft label must indicate
the intended colors of the final label, clear indication
of the front panel of the label, and the intended type
sizes of the text.
2. Within 9 months from receipt of this document you
must submit to the Product Manager:
a. Application for Pesticide Registration (EPA
Form 8570—1).
b. Two copies of any required product—specific data
(See Table B).
c. Product Specific Data Report.
If on the Summary Sheet, you commit to develop the data,
present arguments that a data requirement is not applicable
or should be waived, or submit protocols or modified protocols
for Agency review, you must submit a copy of the Summary
Sheet (and any supporting information) to the Office of
Compliance Monitoring, which will be monitoring the data
generated In response to this notice. This submission is in
addition to responding to the Product Manager, and should be
submitted to the Office of Compliance Monitoring at the
address given at the end of this section. (Actual studies
are not to be submitted to the Office of Compliance Monitoring.)
—40—
-------
3. Within the times set forth in Table A , you must
submit to the Registration Division all generic data, unless
you are eligible for the formulator’s exemption. If for any
reason any test is delayed or aborted so that the schedule
cannot be met, immediately notify the Product Manager and
the Office of Compliance Monitoring of the problem, the
reasons for the problem, and your proposed course of action.
B. Manufacturing Use Products containing Methyl Bromide
in combination with other active ingredients .
1. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division:
a. FIFRA sec. 3(c)(2)(B) Summary Sheet, with appropriate
attachments 5 (EPA Form 8580—1).
b. Confidential Statement of Formula (EPA Form 8570—4)
c. Formulator’s Exemption Statement, if applicable.
2. Within the time frames set forth in Table A , you must
submit to the Registration Division all generic data, unless
you are eligible for the formulator’s exemption. If for any
reason any test is delayed or aborted so that the schedule
cannot be met, immediately notify the Product Manager and
the Office of Compliance Monitoring of the problem, the
reasons for the problem, and your proposed course of action.
C. End Use Products containing Methyl Bromide alone
or in combination with other active ingredients .
1. Within 90 days from receipt of this document, you
must submit to the Product Manager in the Registration Division:
a. FIFRA Section 3(c)(2)(B) Summary Sheet, with
appropriate attachments 5 (EPA Form 8580—1).
b. Confidential Statement of Formula (EPA Form 8570—4).
c. Formulator’s Exemption Statement, if applicable.
—4 1 —
-------
2. Within 90 days from receipt of this document you
must submit to the product manager in the Registration Division:
Three copies of draft labeling, including the container
label and any associated supplemental labeling. Labeling should
be either typewritten text on 8—1/2 x 11 inch paper or a mockup
of the labeling suitable for storage in 8—1/2 x 11 files. The
draft labeling must indicate the intended colors of the final
label, clear indication of the front panel of the label, and
the intended type sizes of the text. End use product labeling
must comply specifically with the instructions in Section 1V
(Regulatory Position and Rationale).
D. Intrastate Products containing Methyl Bromide either
as sole active ingredient or in combination with other
active ingredients .
These products are being called in for full Federal regis-
tration. Producers of these products are being sent a letter
instructing them how to submit an application for registration.
E. Addresses
The required information must be submitted to the following
address:
Jeff Kempter, Acting PM—32
Registration Division (TS—767C)
Office of Pesticide Programs
Environmental Protection Agency
401 M St., SW
Washington, DC 20460
The address for submissions to the Office of Compliance
Monitoring is:
Laboratory Data Integrity Program
Office of Compliance Monitoring (EN—342)
Environmental Protection Agency
401 M St., SW
Washington, DC 20460.
—42—
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GUIDE TO TABLES
Tables A and B contain listings of data requirements
for the pesticides covered by this Registration Standard.
Table A contains generic data requirements that apply to
the pesticide in all products, including data requirements
for which a “typical formulation” is the test substance.
Table B contains product—specific data requirements that
apply only to a manufacturing use product.
The data tables are generally organized according to the
following format:
1. Data Requirement (Column 1). The data requirements are
listed in the order in which they appear in 40 CFR Part 158.
The reference numbers accompanying each test refer to the
test protocols set out in the Pesticide Assessment Guidelines,
which are available from the National Technical Information
Service, 5285 Port Royal Road, Springfield, VA 22161.
2. Test Substance (Column 2). This column lists the composition
of the test substance required to be used for the test, as
follows:
TGAI Technical grade of the active ingredient
PAl = Pure active ingredient
PAIRA = Pure active ingredient, radio labeled -
TEP = Typical end use formulation
MP Manufacturing use product
EP = End use product
Any other test substances, such as metabolites, will be
specifically named in Column 2 or in footnotes to the table.
3. Use pattern (Column 3). This column indicates the use
patterns to which the data requirement applies. Use patterns
are the same as those given in 40 CFR Part 158. The following
letter designations are used for the given use patterns:
A = Terrestrial, food
B = Terrestrial, non—food
C = Aquatic, food
D = Aquatic, non—food
E = Greenhouse, food
F = Greenhouse, non—food
C = Forestry
H = Domestic outdoor
I = Indoor
Any other designations will be defined in a footnote to the table.
—43—
-------
4. Does EPA have data ? (Column 4). This column indicates one
of three answers:
YES — EPA has data in Its files that completely satisfy
this data requirement. These data may be cited by
other registrants in accordance with data compensation
requirements of Part 152, Subpart E.
PARTIALLY — EPA has some data in its files, but such data
do not fully satisfy the data requirement. In some cases,
the Agency may possess data on one of two required species,
or may possess data on one test substance but not all.
The term may also indicate that the data available to
EPA are incomplete. In this case, when the data are
clarified, or additional details of the testing submitted
by the original data submitter, the data may be determined
to be acceptable. If this is the case, a footnote to
the table will usually say so.
NO — EPA either possesses no data which are sufficient
to fulfill the data requirement, or the data which EPA
does possess are flawed scientifically in a manner that
cannot be remedied by clarification or additional infor-
mation.
5. Bibliographic citation (Column 5). If the Agency has
acceptable data in its files, this column lists the Identifying
number of each study. This normally is the Master Record
Identification (MRID) number, but may be a CS number if no
MRID number has been assigned. Refer to the Bibliography
Appendices for a complete citation of the study.
6. Must additional data be submitted ? (Column 6). This
column indicates whether the data must be submitted to the
Agency. If column 3 indicates that the Agency already has
data, this column will usually indicate NO. If column 3
indicates that the Agency has only partial data or no data,
this column will usually indicate YES. In some cases, even
though the Agency does not have the data, EPA will not require
its submission because of the unique characteristics of the
chemical; because data on another chemical can be used to
fulfill the data requirement; or because the data requirement
has been waived or reserved. Any such unusual situations
will be explained in a footnote to the table.
7. Timeframe for submission (Column 7). If column 5 requires
that data be submitted, this column indicates when the data
are to be submitted, based on the issuance date of the Regis-
tration Standard. The timeframes are those established either
as a result of a previous Data Call—tn letter, or standardized
timeframes established by PR Notice 85—5 (August 22, 1985),
8. Footnotes (at the end of each table). Self—explanatory.
—44—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Data Requirement Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Substance
Patterns
Have
Data?
Citation!/
Data be
Submitted?
for
Submission
§158.120 Product Chemistry
Product Identity
61—2 — Description of Beginning TGAI All N/A Yes 6 Months
Materials and Manufacturing
Process
61—3 — Discussion of Formation of TGAI All N/A Yes 6 Months
Impurities
Analysis and Certification of
Product Ingredients
62—1 — Preliminary Analysis TGAI All N/A Yes 12 Months
Physical and Chemical
Characteristics
63—2 — Color TGAI All N/A Yes 6 Months
63—3 — Physical State TCAI All N/A Yes 6 Months
63—4 — Odor TGAI All N/A Yes 6 Months
63—5 — Melting Point TGAI All N/A No2/
63—6 — Boiling Point TGAI All N/A No2/
—45—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Data Requirement Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Substance
Patterns
Have
Data?
Citationh/
Data
be
for
Submitted?
Submission
§158.120 Product Chemistry (Continued)
Physical and Chemical Characteristics
(Continued)
63—7 — Density, Bulk Density, TCAI All N/A Yes 6 Months
or Specific Gravity
63—8 — Solubility TGAI or PAl All N/A Yes 6 Months
63—9 — Vapor Pressure PAt All N/A Yes 6 Months
63—10 — Dissociation Constant PAt All N/A No3/
63—11 — Octanol/Water Partition PAt All N/A Yes 6 Months
Coefficient
63—12 — pH TGAI All N/A Yes 6 Months
63—13 — Storage Stability TGAI All N/A Yes 15 Months
Other Regui rements:
64— 1 — Submittal of Samples TGAI or PAt All N/A Yes 6 Months
1/ Not applicable. Although product chemistry data may have been submitted in the past, the Agency has determined that
these data must be resubmitted for each pesticide. New requirements have been introduced and previously submitted
data must be updated. Therefore bibliographic citations for the old data are not applicable.
2/ Not required because the technical material is a gas at room temperature.
3/ Not required because methyl bromide Is nonionic.
—46—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Data Requirement Substance
Patterns
Have
Data?
Citation
Data be
Submitted?
for
Submission
§158.125 Residue Chemistry
171—4 — Nature of Residue
(Metabolism)
— Plants PAIRA A Partially 00065237,00079550 Yes!/2/ 12 Months
— Livestock PAIRA & Plant A No Reserved3/
Metabolites
171—4 — Residue Analytical
Method
— Plant residues TGAI & A Partially 00026180,00043601 Yes4/5/ 18 Months
Metabolites 00079041,00112926
00118768,00118838
00149535, 00152907
00 153317,00160629
— Animal re8idues TGAI & A No Reserved6/
Metabolites
171—4 — Storage Stability PAl A Partially 00153317 Yes7/ 18 Months
Data
—47—
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TABLE A
GENERIC DATA REQUIREMENTS FOR IETHYL BROMIDE
Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Data Requirement Substance
Patterns
Have
Data?
Citation
Data be
Submitted?
for
Submission
§158.125 Residue Chemistry — Continued
171—4 — Magnitude of the Residue —
Residue Studies8/9/
— Root and Tuber
Vegetables Group
o Jerusalem
Artichokes
o Ginger Roots
o Horseradish
o Parsnip Roots
o Salsify Roots
— Bulb Vegetables Group
— Leafy Vegetables Group
Yes 11/
Yes 11
YesI 1/
YesI 1/
YesI 1/
Yes 12/
Yes 13/
24 Months
24 Months
24 Months
24 Months
24 Months
24 Months
24 Months
TEP
Yes 10/
24 Months
A
TEP A
TEP A
Partially 00088683,00089457
00090408,00119550
00152907,00153317
No
Partially 00090408,00119550
No
No
No
Partially 00079043,00088683
00089457,00152907
00153317
PartIally 00079048,00152907
00157445
—48—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Data Requirement Substance
Patterns
Have
Data?
Citation
Data be
Submitted?
for
Submission
§158. 125 Residue Chemistry — Continued
171—4 — Magnitude of the Residue —
Residue Studies
— Brassica Leafy TEP A Partially 00013057,00140445 Yesl4/15/ 24 Months
Vegetables Group 00152907,00153317
00157445
— Legume Vegetables Group TEP A Partially 00088683,00089457 Yesl6/ 24 Months
00118817,00127221
00152907,00153317
— Fruiting Vegetables TEP A,E Partially 00013000,00013057 Yesl7/ 24 Months
(Except Cucurbits) 00088683,00089457
Group 00118837,00135683
00152907 ,00153317
— Cucurbit Vegetables TEP A Partially 00013057,00089457 Yesl8/ 24 Months
Group 00152907,00153317
— Citrus Fruits Group TEP A Partially 00066267,00089457 Yesl9/ 36 Months
00153317
— Pome Fruits Group TEP A Partially 00088683,00118837 Yes2O/ 36 Months
00153317,00160628
— Stone Fruits Group TEP A Partially 00089457,00149535 Yes2l/ 36 Months
00153317 ,001 60628
—49—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Data Requirement Substance
Patterns
Have
Data?
Citation
Data be
Submitted?
for
Submission
§158.125 Residue Chemistry — Continued
171—4 — Magnitude of the Residue —
Residue Studies
— Small Fruits And TEP A Partially 00012999,00013057 Yes22/ 24 Months
Berries Group 00089457,00096432
00118829,00118845
0012776 7,00149535
00152907,00153317
— Tree Nuts Group TEP A Partially 00088683,001 18821 Yes23/ 36 Months
00119256,00149535
00153317
— Cereal Grains Group TEP A Partially 00088683,00089457 Yes24/ 24 Months
00090269,00109713
00118817,00118820
001 18838,00149535
00153317
— Nongrass Animal TEP A Partially 00088683,001 18830 Yes2S/ 24 Months
Feeds Group
— Herbs and Spices Group TEP A Partially 00090408,00118838 Yes26/ 24 Months
00119550,00152907
00153317,00160627
—50—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Data Requirement Substance
Patterns
Have
Data?
Citation
Data be
Submitted?
for
Submission
§158.125 Residue Chemistry — Continued
171—4 — Magnitude of the Residue —
Residue Studies
— Miscellaneous Commodities
o Asparagus TEP A Partially 00079048,00090147 Yes27/ 24 Months
o Avocados TEP A Partially 00135683 Yes2B/ 24 Months
o Cocoa Beans TEP A Partially 00088683,00153317 Yes29/ 24 Months
o Coffee Beans TEP A Partially 00090408,00119550 Yes3O/ 24 Months
00153317
o Copra TEP A Partially 00089457,00118838 Yea3l/ 24 Months
o Cottonseed TEP A Partially 00088683 Yes32/ 24 Months
o Okra TEP A Partially 00152907 Yes33/ 24 Months
—51—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Data Requirement Substance
Patterns
Have
Data?
Citation
Data be
Submitted?
for
Submission
§158.125 Residue Chemistry — Continued
171—4 — Magnitude of the Residue —
Residue Studies
o Peanuts TEP A Partially 00088683,00089066 Yes34/ 24 Months
00109713,00119256
00125059
o Pineapples TEP A Partially 00012908 Yes3 S/ 24 Months
o Pistachio Nuts TEP A Partially 00149535 Yes36/ 24 Months
o Tobacco TEP B Partially 00153317 Yes37/ 24 Months
o Processed Foods TEP N/A Partially 00088683,00109713 Yes38/ 24 Months
00118817,00118837
00118838,00153317
O Meat/Milk TG&I or Plant N/A Partially 00090270,00090271 Reserved39/
Poultry/Eggs Metabolites 00118825
—52—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
§158.125 Residue Chemistry — Continued
1/ Representative raw agricultural commodities, harvested according to common conunercial procedures, are to be
fumigated with [ 14 C]—inethyl bromide at or above the maximum registered rate and under conditions comparable
to those specified in the label directions. Considering the relatively brief duration of these studies, the
use of 1 14 C, 7490 Br] double—labeled methyl bromide may be feasible (half—lives of the various isotopes of Br
are 1.6 sec to 57 hr). In addition to methyl bromide L8C (MeBr 2 Lse) and inorganic bromide ion (iBr),
methylated and brominated derivatives of natural plant constituents produced upon fumigation must be characterized,
particularly such products as purine and pyrimidine bases. It is advisable to combine the metabolism study with
storage stability and method recovery studies as an optimal means of validating the residue data. Representative
members of at least the following crop groups [ as defined in 40 CFR 180.34(f)] must be tested: root and tuber
vegetables, tree nuts, cereal grains (corn and a small grain), citrus fruits, pome or stone fruits, and nongrass
animal feeds. The major crops in the above or other groups must be included.
2/ If the plant metabolism studies (postharvest commodity fumigation) reveal the formation of residues of concern
other than methyl bromide se and bromide ion, then preplant soil fumigation type plant metabolism studies may
also be required.
3/ May be required if the plant metabolism studies reveal the presence of residues of concern in raw agricultural
commodities used for animal feed.
4/ Bromide analysis — Fortification/recovery data validating the methods of Shrader et al. (Method Pr 6e—64), Heuser
and Scudamore (IR—4), and Abdalla and Lear as well as Method SSL 57.3, Method ML—Ml—69—57, and the WIL 84:7
procedure. Individual values must be reported for each food/feed analyzed; Methyl bromide analysis — Fortification/
recovery data validating the WIL 84:7 procedure. Individual values must be reported for each food/feed analyzed;
Neutron activation analysis — Thi8 method must be described in detail and it muSt be specified whether the X—ray
diffraction or the oxidation/titration method was used.
5/ If the requested plant metabolism studies reveal the presence of additional metabolites of concern, then residue
analytical methods may be required to determine these residues in RAC’s and/or processed products.
6/ If residues of concern are detected in the reserved animal metabolism studies, then feeding studies will be
required to determine the necessity and levels of any tolerances.
—53—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
§158.125 Residue Chemistry — Continued
7/ Representative fumigated and/or spiked commodities must be analyzed for iBr at various intervals following the end
of the aeration time prescribed on registered labels. The end of aeration will represent time zero. Untreated
controls should be included as a means of determining background levels of iBr. A validated method of analysis
must be used. It should also be noted that all residue data (iBr and methyl bromide 2 se) in this Standard must
be accompanied by data regarding storage length and conditions of storage of samples analyzed. These data must be
accompanied by data depicting stability of residues under the conditions and for the intervals specified.
8/ In the event that the requested plant metabolism studies reveal the presence of new metabolites of concern, then
representative data will be required (upon receipt of the metabolism studies) showing the residues of these
metabolites in or on treated foods or feeds.
9/ Preplant soil fumigation data have been submitted which indicate that the Indiana (and perhaps Oklahoma) soil(s)
in which crops were grown may not be typical. Several crops grown in these soils (root crops, lettuce,
succulent beans, tomatoes, peppers, and watermelon) contained unusually high levels of inorganic bromides (iBr)
compared with other States tested. Therefore, the reason(s) for the unusually high inorganic bromide (iBr) levels
In crops grown in Indiana (and perhaps Oklahoma) soil fumigated preplant must be provided. Soil profiles,
treatment histories, and any other pertinent data should accompany the explanation.
10/ Postharvest commodity fumigation of each registered raw agricultural commodity (RAC) at the maximum registered
rate and for the maximum registered exposure period as listed in the EPA Index to Pesticide Chemicals (Appendix
III) must be submitted. If crop group tolerances for iBr and MeBr se are to be sought, then only data
(reflecting the maximum rates and exposure periods) for carrots, potatoes, radishes, and sugar beets need be
submitted. Several trials must be conducted for each RAC to be tested; these trials must represent the major
application methods and, in the case of chambers, two or more commercial types of units must be used. These
application methods should at least be commercial fumigation chambers (atmospheric pressure and partial
vacuum); railroad cars; trucks, vans, or trailers (whichever is the most prevalent); and simple tarpaulin
fumigation (stacking of the RAC and covering with a gasproof film). Processed products of potatoes and
sugar beets derived from fumigated RAC’s (bearing measurable residues) must also be analyzed to determine if
concentration of iBr or MeBr R i se occurs. For preplani soil fumigation use, samples must be first grown in
fumigated soil and then fumigated postharvest at the maximum rates. If one or two fumigation methods predominate
the commercial market, then only the major techniques must be tested provided that the petitioner provides evidence
supporting this claim (and perhaps a label restriction). If one or more members of this crop group teven if not
one of the four representative commodities listed in 40 CFR 180.34 (f)) are more than occasionally (perhaps > 5
percent of the fumigated crop) multiply—treated, then several postharvest fumigations of the same samples must
occur prior to analysis. It is advisable that the petitioner propose minimum aeration times for each RAC if MeBr
residues are detected.
—54—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
§158.125 Residue Chemistry — Continued
11/ Although iBr tolerances and registered uses exist for Jerusalem artichokes, ginger roots, horseradish, parsnip
roots, and salsify roots, the residue data for ginger roots is insufficient and no residue data for the other
commodities supporting these tolerances are available for review. If the petitioner wishes to retain these
individual uses/tolerances, then residue data supporting tolerances for both iBr and MeBr £ L se must be submitted
for each of these crops. If a crop group tolerance is desired, then the petitioner must satisfy all requirements
listed under footnote 13.
12/ Bulb onions are to be grown in soil fumigated at 300 lb al/A in CA and OR and at 240 lb al/A in CO, NY, and
TX, analyzed for iBr and MeBr .2 se, then fumigated postharvest at 3 lb ai/1000 ft 3 for 6 hours (large dry
bulb onions) or 4 lb ai/l000 ft for 4 hours (cipollini or small onion bulbs),• and then analyzed again for
iBr and MeBr Be. Garlic must be fumigated only postharvest at 3 lb ai/100 0 ft 3 for 4 hours (atmospheric)
and 4 lb al/1000 TP for 4 hours (vacuum) and analyzed for both iBr and MeBr 2 L se. Several trials should
be conducted for garlic and onions and postharvest fumigations must be conducted in all of the following
sites unless they are not used commercially: chambers (atmospheric and reduced pressure); railroad cars; trucks,
vans, or trailers; and simple tarpaulin—covered stacks. If multiple treatments of > 5 percent of any member
of this crop group occurs, then data must reflect these. Aeration times must be proposed If MeBr residues
are detected.
13/ MeBr se must be sought at the 400 lb al/A rate (LX) in CA and both leaf and head lettuce must be tested.
Also, the petitioner/registrant must specify whether the iBr data submitted to date for lettuce represent leaf or
head lettuce (or both). If the iBr data submitted thus far do not include both lettuce types, then additional
data will be required. If the petitioner/registrants do not wish the CA use limitation to apply to all products,
then additional studies must be conducted in AZ and FL which produce 18.7 percent and 3.8 percent, respectively,
of the lettuce crop according to the 1984 Agricultural Statistics (p. 160; CA produces 69.4%). Celery, lettuce,
and spinach are to be fumigated postharvest at 4 lb ai/1000 ft 3 for 2 hours in a chamber at normal atmospheric
pressure as per the USDA Section 18 quarantine use. MeBr se and iBr must be determined. Aeration should occur
until MeBr 2 se is nondetectable (at least < 0.01 to < 0.001 ppm). If a crop group tolerance is sought, then
data on spinach will be required (application types and rates to be proposed by registrants) as well as the
following data on celery: preplant soil applications (presumably at the 240 lb al/A rate proposed in PP#5F3198)
made in FL (21.8% of U.S. crop) and MI (7.4%), making sure that the maximum rate is used and that both IBr and
MeBr se are sought.
—55—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
§158.125 Residue Chemistry — Continued
14/ Broccoli and cauliflower must be analyzed for lBr and MeBr se following preplant soil fumigation at 240 lb
ai/A in CA and AZ. Cauliflower must also be treated in NY and OR. Broccoli, cabbage, and mustard greens are
to be fumigated postharvest at 4 lb al/A 1000 ft 3 for 2 hours in a chamber at normal atmospheric pressure
as per the USDA Section 18 quarantine use. MeBr se and iBr must be sought. Aeration should occur until
MeBr p se is nondetectable (at least < 0.01 to < 0.001 ppm). If crop group tolerances are sought, then
data must also be submitted for mustard greens. Broccoli, cabbage, and mustard greens (or a suitable
substitute if greens are not fumigated postharvest) must be treated both preplant and postharvest at the
maximum rates; iBr and MeBr ise must be sought after each fumigation.
15/ Data were presented for brussels sprouts, chinese cabbage, collard greens, kale, and mustard greens.
However, no tolerances or registered uses exist for these crops. Therefore, the data are only useful for
supporting the crop group tolerances proposed in PP#5F3198 and PPI/5F3300. Mustard greens are one of three
representative commodities (other than cabbage and broccoli) listed for this crop group in 40 CFR 180.34(f).
Due to the very high iBr levels found in mustard greens grown in fumigated IN and OK soil (648 to 1360 ppm),
further testing should occur in CA (17.8%), TX (12.1%), and AZ (12%) if a crop group tolerance is desired.
The parenthetic numbers are percentages of U.S. acreage oi mustard greens harvested (from 1982 Census of
Agriculture).
16/ Succulent and dried beans must be fumigated postharvest at 3.5 lb ai/1000 ft 3 for 24 hours, dried peas at 4 lb
aI/1000 ft 3 for 24 hours, and succulent peas at 3 lb ai/L000 ft 3 for 2 hours. Several methods of fumigation must
be used for each commodity including chamber (atmospheric and reduced pressure); truck, van, or trailer; boxcar;
and simple tarpaulin—covered stacks. Repeat fumigations (at least in the case of dried beans and peas) must be
conducted if commercially practiced. At least lima and a smaller Phaseolus app. should be fumigated as well as
succulent peas ( Pisum spp.) and dried southern peas ( Vigna spp.). If a crop group tolerance is desired, then
soybean data must also be submitted which reflect some proposed application rate and exposure period. Both iBr
and MeBr se must be sought in all cases. Prior to approval of preplant soil fumigation uses (PP#5F3198),
samples of the above commodities must be grown in soil fumigated at the maximum rate in the major growing areas,
then analyzed for iBr and MeEr se, then fumigated postharvest at the maximum rate using several methods of
fumigation, and then reanalyzed for MeBr p se and iBr. Aeration periods should be proposed for Inclusion on
the label for postharvest fumigations. If the soybean data is developed, then a processing study must be
conducted to determine if iBr or MeBr p se concentrates in any processed product(s). [ Processed products must
be derived from soybeans bearing measurable weathered residues of MeEr a se and iBr.] Calibration curves must
be submitted for all crops analyzed for MeBr 2. L se by the method of King et al. for validation purposes.
—56—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
§158.125 Residue Chemistry — Continued
17/ Eggplant, peppers, and tomatoes must be grown in soil fumigated preplant at 240 lb ai/A in geographically
representative areas and then analyzed for MeBr se and iBr. Tomatoes should also be greenhouse grown in
soil fumigated replant at 240 lb al/A. The samples grown in treated soil must then be fumigated postharvest at
3 lb al/I 00 0 ft (eggplant and tomatoes) or 4 lb ai/1000 ft 3 for 2 hours (peppers) and, after suitable aeration
periods, analyzed again for iBr and MeBr The most commercially prevalent methods of postharvest
fumigation (e.g., boxcar, vacuum, tarpaulin) must be tested as well as repeat applications, if practiced
commercially. Label restrictions may be required to prevent preplant soil fumigation in areas having soil such
as that in IN which, for many commodities, results in unusually high ifir residues. If a crop group tolerance is
sought, then the eggplant data gap does not apply. A tomato processing study must be conducted to determine if
residues of iBr or MeBr se concentrate in any processed product(s) and to support the 250 ppm tolerance for
iBr in concentrated tomato products (21 CFR 193.250). [ Processed products must be derived from tomatoes bearing
measurable weathered residues of iBr and MeBr se.] MeBr se data for tomatoes determined using the King
et al. method must be validated by the submission of a calibration curve.
18/ Cantaloupes, cucumbers, inuskmelons, pumpkins, squash (winter and summer), and watermelons must be fumigated
postharvest at the maximum registered rates: 2.5 lb ai/1000 ft 3 for 2 hours for cantaloupe, muskmelons, and
watermelons; 2.5 lb ai/1000 ft 3 for 4 hours for cucumber; and 4 lb ai/1000 ft 3 for 2 hours in the case of
pumpkins and summer and winter squash. The most commercially prevalent methods should be used (vacuum, boxcar,
tarpaulin—covered stacks.), and multiple treatments should be made if > 5 percent of the crop receives more
than one treatment. Both MeBr se and iBr should be sought in several trials for each crop. Aeration times
should be added to labels. If crop group tolerances are sought, then the abov e data will be required only for
the representative commodities cucumber, melons, and summer squash. In the case of muskmelons (and all
representative commodities prior to approval of the preplant soil uses proposed in PP#5F3!98), fruit must be
grown in soil treated preplant in AZ, CA, and TX at 240 lb ai/A and then fumigated postharvest; iBr and MeBr se
should be sought before and after the postharvest fumigation.
19/ Sweet orange, lemons, and grapefruit must be planted in soil fumigated preplant at 870 lb al/A (2 lb ai/tree
site). Two years later (or as soon as ripe fruit first appear), fruit are to be harvested and fumigated post—
harvest at 3 lb ai/1000 ft 3 for 2 hours using the mo8t prevalent methods (vacuum, boxcar, trailer, tarpaulin—
covered stacks, etc.), used commercially. If multiple treatments occur commercially, these fruit should receive
multiple treatments. MeBr p se and iBr should be determined before and after the postharvest fumigation.
Oranges should be grown in AZ, CA, and FL, grapefruit in CA, FL, and TX, and lemons in AZ and CA. Aeration periods
should be proposed. Calibration curves must be submitted to validate MeBr se data generated using the method
of King et al. Processed products (dried pulp, peel, oil, molasses, and juice) derived from RAC’s bearing
measurable weathered residues should be analyzed to determine if concentration occurs upon processing.
—57—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
§158.125 Residue Chemistry — Continued
20/ Apples, pears, and quinces must be grown in soil (in geographically representative areas) which has been
fumigated preplant at 870 lb al/A (2 lb ai/tree site). Two years after treatment (or as soon as ripe fruit can
be obtained), fruit should be fumigated postharvest at 5 lb al/1000 ft 3 for 2 hours using the predominant
commercial procedures such as boxcar, vacuum, or tarpaulin—covered stacks. If multiple treatments occur
commercially, these should be conducted. MeBr j se and iBr should be determined before and after the postharvest
fumigation. Aeration periods should be proposed. Calibration curves must be submitted to validate data on MeBr
se generated using the King et al. method. Processed products derived from apples bearing measurable
weathered residues must be analyzed to determine if concentration of residues occurs upon processing. [ Note that
if a crop group tolerance is proposed, data need be submitted for apples and pears only, since the registered uses
on apples, pears, and quinces are identical.]
21/ Apricots, cherries, nectarines, peaches, and plums must be grown in geographically representative areas in soil
fumigated preplant at 870 lb al/A. Fruit should be harvested 2 years posttreatment (or as soon as ripe fruit are
available) and then subjected to postharvest fumigation at 5 lb ai/1 00 0 ft 3 for 2 hours. The most prevalent
commercial fumigation methods (such as vacuum, boxcar, or tarpaulin) should be used. If multiple treatments are
made to > 5 percent of the crop, then these must be conducted. Both iBr and MeBr se must be sought before and
after the postharvest fumigation. Calibration curves must be submitted for each crop analyzed for MeBr 2 se
using the method of King et al. Raw data (not mean values) must be submitted in every case. Aeration periods
should be proposed. Fresh prunes bearing measurable weathered residues should be analyzed for both MeBr
and iBr before and after drying to determine if residue concentration occurs. If group tolerances are sought,
then only data cited above for cherries, peaches, and plums/prunes are required.
22/ Blueberries should be fumigated postharvest at 2 lb ai/1000 ft 3 for 4 hours. Grapes are to be grown in
representative areas in soil fumigated preplant at 600 lb ai/A and the grapes, harvested as soon as possible from
treated sites, and then fumigated postharvest at 4 lb ai/1000 ft 3 for 2 hours. Strawberries are to be grown in
CA, FL, and OR in soil fumigated preplant at 240 lb ai/A; the berries, harvested as soon as pos8ible from treated
sites, are to be fumigated postharvest at 3 lb ai/1000 ft 3 for 4 hours. For all crops above, if multiple
treatments are made commercially, then these must be conducted. Several commercially predominant methods must
be tested such as vacuum, trailer, boxcar, and tarpaulin fumigation. MeBr a se and iBr should be sought after
preplant treatment (if applicable) and after postharveat fumigation. Aeration periods should be proposed for
postharvest uses. Calibration curves must be submitted to validate MeBr a L se data generated using the King et
al. method (1981). Grapes fumigated both preplant and postharvest and bearing measurable residues are to be
processed into raisins, wet and dry pomace, raisin waste, and juice to determine if residue concentration occurs
upon processing. If a crop group tolerance is sought, then data on a Rubus app. (such as raspberries for which
some data are available) and cranberry should be generated which reflect proposed uses.
—58—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
§158.125 Residue Chemistry — Continued
23/ Almonds, pecans, and English walnuts are to be grown in soil fumigated prep].ant at 870 lb al/A and then fumigated
postharvest at 3.5 lb ai/1000 ft 3 for 24 hours as soon as ripe nuts are available from treated plots or 2 years
later, whichever is longer. Several fumigation methods should be tested (such as vacuum, boxcar, tarpaulin)
If such methods are used commercially. If > 5 percent of the nut crop are fumigated more than once, then the
maximum number used commercially should be tested. MeBr a se and lEt should be determined before and after the
postharvest fumigation(s). Sampling should be continued until MeBr 2 se is nondetectable (preferably approaching
0.001 ppm). This will allow establishment of an aeration period. Almond hulls must also be analyzed as above.
If crop group tolerances are not sought , then data similar to that cited above must be submitted for Brazil nuts,
butternuts, chestnuts, filberts, hickory nuts, and macadamia nuts.
24/ Fresh sweet corn should be fumigated postharvest at 3 lb ai/1000 ft 3 for 4 hours, field corn at 4 lb ai/1000 ft 3
for 12 hours, popcorn at 1.5 lb ai/L000 fc 3 , rice and wheat at 6 lb ai/ I000 ft 3 for 12 hours and 3 lb aI/
1000 ft 3 for 24 hours, and sorghum at 6 lb ai/L000 ft 3 for 12 hours. Both iBr and HeRr p se must be sought.
[ For fresh sweet corn, kernels plus cobs with husks removed should be analyzed.] The most commercially important
fumigation procedures must be tested such as vacuum, boxcar, silo, etc. If repeat applications are commercially
typical, these are to be tested. Aeration should continue until MeBr p se is nondetectable (< 0.001 ppm, if
possible) to allow the proposal of aeration intervals. The above studies should also be conducted for barley,
oats, and rye if crop group tolerances are not to be sought. Processing studies should be conducted on field
corn, rice, and wheat grain bearing measurable weathered residues of MeBr se to determine if residues
concentrate in processed products.
25/ Alfalfa hay is to be fumigated postharvest at 3 lb ai/1000 ft 3 for 24 hours ustng the most commercially prevalent
methods (such as vacuum, tarpaulin, or trailer). If multiple treatments occur to > 5 percent of the treated crop,
then these must be reflected. Both iBr and MeBr se must be sought. An aeration Interval should be proposed.
Alfalfa meal prepared from fumigated hay bearing measurable residues must also be analyzed to determine if residue
concentration occurs.
26/ Basil, chives, dill, marjoram, and sage must be fumigated several times at 3 lb ai/1000 ft 3 ( IX) for 24 hours to
simulate fumigation In the exporting country, in transit (ship), at the port, and in storage in the United States.
Several methods of fumigation must be tested If used commercially (ship hold, vacuum, tarpaulin, etc.). Both iBr
and MeBr p se must be sought. Aeration periods should be proposed. Prior to approval of the preplarit soil
fumigation use (proposed In PPI/5F3198), samples must be grown in treated soil and then multiply fumigated
postharvest at the IX rate for 24 hours.
—59—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
§158.125 Residue Chemistry — Continued
27/ Asparagus must be grown in CA in soil fumigated preplant at 400 lb al/A and in MI and WA in soil treated at 240 lb
al/A. MeBr se and iBr must be sought. Asparagus grown in fumigated soil must be fumigated postharvest at 4 lb
ai/1000 ft 3 for 2 hours in a chamber at atmospheric pressure prior to residue analysis. An aeration interval
following postharvest fumigation should be proposed 0
28/ Avocados must be fumigated postharvest at 2 lb ai/1000 ft 3 for 4 hours in a chamber (and any other method used
commercially in CA) at atmospheric pressure. Both iBr and MeBr se must be determined. Aeration must be
continued until MeBr se dissipates to below detectable levels (< 0.01 to < 0.001 ppm) and an aeration interval
should be proposed.
29/ Cocoa beans (unroasted) must be fumigated postharvest at 1.5 lb al/IOU 0 ft 3 for 12 hours in a chamber. Both iBr
and MeBr se must be determined. Aeration must be continued until MeBr se is nondetectable (< 0.01 to
<0.001 ppm) and an aeration interval should be proposed. If multiple fumigations are practiced commercially,
these must also be conducted. Residues must be determined in roasted beans, cocoa powder, and chocolate processed
from fumigated cocoa beans bearing measurable residues.
30/ Green coffee beans and/or roasted beans (as per commercial practice) are to be fumigated postharvest at 2.5 lb
al/ I0 0 0 ft 3 for 24 hours using various fumigation techniques such as vacuum chamber, ship hold, or tarpaulin
(whichever are commercially predominant). If multiple fumigations are practiced commercially, then data should
reflect such treatment. MeBr P L se and iBr must be sought. It must be specified whether green or roasted beans
are treated. The dosage and exposure time for the MB se study (PP#5F3300) must be specified. A calibration
curve should be submitted to validate data on MeBr se generated using the King et al. method. Residues must
be determined in roasted beans and instant coffee processed from fumigated green beans bearing measurable residues.
If roasted beans are fumigated, then residues must be determined in roasted beans and in Instant coffee processed
from roasted beans bearing measurable residues resulting from this use.
31/ Copra is to be fumigated repeatedly (as per commercial custom) at 2.5 lb ai/1000 ft 3 for 24 hours using the
prevalent commercial techniques (vacuum chamber, ship hold, tarpaulin, etc.). Both iBr and MeBr . ise are to be
sought. Aeration must continue until MeBr se is nondetectable (< 0.0! to < 0.001 ppm) and an aeration interval
should be proposed.
32/ Cottonseed are to be fumigated repeatedly (as per commeicial Custom) in a chamber at normal pressure at 9 lb all
1000 ft 3 for 12 hours and at 4 lb ai/I 0 0 0 ft 3 for 24 hours, under a tarpaulin at 9 lb ai/1000 ft 3 for 12 hours,
and 6 lb ai/1000 ft 3 for 24 hours and under 660 minHg vacuum at 9 lb ai/1000 ft 3 for 3 hours. Both iBr and MeBr
se are to be determined. Aeration must continue until MeBr se Is nondetectable (<0.01 to < 0.001 ppm) and
an aeration interval should be proposed. Residues are to be determined in meal, hulls, soapstock, crude oil, and
refined oil prepared from fumigated cottonseed bearing measurable residues to determine whether concentration
occurs upon processing.
—60-.
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
§158. 125 Residue Chemistry — Continued
33/ Okra is to be fumigated (repeatedly, if this Is a common practice) postharvest at 3.5 lb aI/1000 ft 3 for 2 hours
in a chamber at normal atmospheric pressure. Both t Sr arid MeEr !. se are to be determined. Aeration should
preferably continue until MeBr p se is nondetectable (< 0.01 to < 0.001 ppm) and an aeration interval should be
propo8ed. Prior to approval of the proposed preplant soil fumigation use (PP#5F3198), data reflecting both
preplant and postharvest fumigation of the same samples will be required.
34/ Peanuts are to be fumigated postharvest (repeatedly, if this is the commercial practice) at 3.5 lb ai/1000 ft 3
for 24 hours. The most prevalent fumigation methods should be tested (vacuum, boxcar, tarpaulin, etc.). Both iBr
and MeBr se should be sought. Aeration should preferably continue until MeBr se is nondetectable (< 0.01
to < 0.001 ppm) and an aeration interval should be proposed. Residues should be determined in meal, soapstock,
crude oil, and refined oil processed from fumigated peanuts bearing measurable residues to determine whether
concentration occurs upon processing.
35/ Pineapples are to be grown in representative areas in soil fumigated preplant at 240 lb ai/A. As soon as
harvestable fruit are available, they should be fumigated postharvest at 2 lb ai/1000 ft 3 for 6 hours using the
most prevalent methods (ship hold, vacuum, tarpaulin, etc.). If multiple treatments are typical, they should be
conducted. MeBr se and iBr should be determined before and after the postharvest fumigation. Aeration should
preferably continue until MeBr 2 se is noiidetectable (< 0.01 to < 0.001 ppm) and an aeration interval should be
proposed. Residues in pineapple bran and juice processed from pineapple bearing measurable weathered residues
should also be determined to discover if concentration of residues occurs.
36/ Pistachio nuts are to be fumigated postharvest (repeatedly, if commercially conducted) at 3.5 lb ai/1000 ft 3 for
24 hours. The prevalent fumigation techniques should be tested such as vacuum, ship hold, boxcar, etc. Both iBr
and MeBr se should be sought. Aeration must continue until MeSt se is nondetectable (< 0.01 to < 0.001
ppm) and an aeration interval should be proposed. The methods of analysis must be Identified for existing studies.
If the King et al. method is used, a calibration curve must be submitted.
—61—
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TABLE A
GENERIC D Th REQUIRE 1ENTS FOR METHYL BRC 4IDE
§158.125 Residue Chemistry — Continued
37/ Tobacco should be grown in NC (38.3% of daiiestic production) and KY (22.7%) in soil fumigated preplant
at 872 lb ai/A. According to canrnercial procedures, the tobacco above should be harvested and fumigated
postharvest in a chamber (atmospheric pressure) at 3 lb ai/l000 ft 3 for 72 hours, in a warehouse at
4.5 lb ai/1000 ft 3 for 24 hours, and in a vacuum chamber (at about 675 mmHg) at 4 lb ai/l000 ft 3 for
4 hours. If leaves are fumigated both green and cured, then both must be tested. If tobacco is fumigated
both hanging and baled, both are to be tested. MeBr se and iBr must be sought both before and after the
postharvest fumigation. Aeration must continue until MeBr se is nondetectable (< 0.01 to < 0.001 pun) and an
aeration interval should be proposed. If MeBr j se is detectable in or on dried or cured tobacco, pyrolysis
products must be characterized and quantified in sm e. If several postharvest treatments occur to the same
leaves caitmercially (regardless of method), then these must be represented. The test parameters (rate, exposure
time, pressure, ten erature, etc.), should be sub nitted as should calibration curves if the method of King et al.
is used.
38/ Chocolate candy, cheese, meats, dried eggs, corn meal, rolled oats, flours, several dried fruits, and several other
representative miscellaneous processed products are to be fumigated in storage at 2 lb ai/1000 ft 3 for 24 hours
(1.5 lb ai/l000 ft 3 for 24 hours in the case of dried fruits). If multiple fumigations of all or sane of these
items occurs, then the data should reflect this. Several fumigation techniques (ship hold, vacuum and atmospheric
chamber, boxcar, tarpaulin) should be tested. Both MeBr se and iBr should be determined. Aeration must
continue until MeBr Se is nondetectable (< 0.01 to < 0.001 ppii) and an aeration interval should be proposed.
[ sage and exposure duration used in the studies of MeBr se subnitted with PP#5F3300 must be provided as must
calibration curves for all foods analyzed using th method of King et al.
No conclusions can be reached at this time as to the magnitude of residues of MeBr se or iBr in animal products
because the magnitude of residues in feed items, metabolism in plants, and (if required) metabolism in animals
are not adequately defined. Upon receipt of these data, the necessity/magnitude of tolerances for MeBr se
and iBr in animal products will be determined.
—62—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Data Requirement Test
Use
Does
EPA
Bibliographic
Must Additional
Time Frame
Substance
Patterns
Have Data?
Citatton
Data be
Submitted?
for
Submission
§158.130 Environmental Fate
DEGRADATION STUDIES-LAB :
161—1 — Hydrolysis TGAI or PAIRA A,B,E,F Yes 00147718 No
Photodegradation
161—2 — In Water TGAI or PAIRA A,B No Yes 9 Months
161—3 — On Soil TGAI or PAIRA N/A No No!!
161—4 — in Air TGAI or PAIRA A,B,E,F No No2/
METABOLISM STUDIES—LAB :
162—1 — Aerobic Soil TGAI or PAIRA A,B,E,F No Yes3/
162—2 — Anaerobic Soil TGAI or PAIRA A,B No Yes3/
162—3 — Anaerobic Aquatic TGAI or PALRA N/A No No4/
162—4 — Aerobic Aquatic TGAI or PAIRA N/A No No4/
MOBILITY STUDIES :
163—1 — Leaching and TGAI or PAIRA N/A No Yes3/
Adsorption/Desorption
163—2 — Volatility (Lab) TEP N/A No No2/
163—3 — Volatility (Field) TEP N/A No No2/
—63—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Data Requirement Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Substance
Patterns
Have
Data?
Citation
Data be
Submitted?
for
Submission
§158. 130 Environmental Fate — Continued
DISSIPATiON STUDiES—FIELD :
164—1 — Soil TEP A,B,E,F No Yes3/
164—2 — Aquatic (Sediment) TEP N/A No No /
164—3 — Forestry TEP N/A No NoS/
164-4 — Combination and TEP N/A No No6/
Tank Mixes
164-5 — Soil, Long—Term TEP A,B No Reserved7/
ACCUMULATION STUDIES :
165—1 — Rotational Crops PAIRA A,B,E,F No Reserved8/
(Confined)
165—2 — Rotational Crops TEP A,B No Reserved9/
(Field)
165—3 — Irrigated Crops TEP N/A No No2/
165-4 — In Fish TGAI or PAIRA A,B No NolO/
165—5 — In Aquatic Non—Target TEP A,B No NoIO/
Organisms
—64—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
§158.130 Environmental Fate — Continued
!/ Not required because the product will not remain on the soil surface where it will be subjected to light.
2/ Not required because this product is intended Co volatize.
3/ These data have been received by the Agency and are currently under review.
4/ Not required because there are no aquatic or aquatic impact uses.
5/ Not required because there are no forestry uses.
6/ Not required because of the nature of the registered use patterns for methyl bromide.
7/ May be required unless soil residues have dissipated below 50% of the Initial treatment prior to subsequent treatment.
8/ Development of this data is contingent upon the results of the data submitted to support residues In target crops.
9/ Development of this data is contingent upon the results of the confined accumulation studies.
10/ Not required because the octanol/water partition coefficient is 15.5:1.
—65—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Date Requirement Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Substance
Patterns
Have
Data?
Citation
Data
Submi
be
tted
for
Submission
§ 158. 135 Toxicology
ACUTE TESTING :
81 —! — Acute Oral Toxicity — Rat TGAI A,B,E,F,I Yes 00159664 No
81—2 — Acute Dermal Toxicity TGAI A,B,E,F,I Yes 00159664 No
— Rabbit
81—3 — Acute Inhalation Toxicity TGAI A,8,e,F,I Yes 00159664 No
- Rat
81—7 — Delayed TGA1 N/A No Nol/
Neurotoxicity — Hen
SUBCHRONIC TESTING ;
82—1 — 90—Day Feeding: TGAI A,B,E,F I No
— Rodent, and No /
— Non—Rodent (Dog) No2/
82-2 — 21—Day Dermal — Rabbit TGAI N/A No No3/
82—3 — 90—Day Dermal — Rabbit TCAI N/A No No3/
82—4 — 90—Day Inhalation: TGAI A,R,E,F,I No
— Rat, and Yes4/ 15 Months
— Rabbit Yes4/5/ 15 Months
82—5 — 90—Day Neurotoxicity; TGAI A,B,EF,I No Nol/
— Hen —66—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Data Requirement Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Substance
Patterns
Have
Data?
Citation
Data be
Submitted?
for
Submission
§158.135 Toxicology — Continued I
CHRONIC TESTING :
83—1 — Chronic Toxicity — TGAI A,8,E,F,I
2 Species:
— Rodent (Rat), and No Yes6/ 50 Months
— Non—rodent (Dog) No Yes 6 ! 50 Months
83—2 — Oncogenicity — TGAI A,B,E,F,I No
2 Species:
— Rat (preferred), and No Yes / /
— Mouse (preferred) No Yes6/L/
83—3 — Teratogenicity — TCAI A,B,E,F,I
2 Species:
— Rat Yes 00102990 No
— Rabbit No Yes 15 Months
83—4 — Reproduction — Rat TGAI A,B,E,F,I No Yes6/8/ 39 Months
2—Generation
MIJTACENICITY TESTING
84—2 — Gene Mutation (Ames Test) TCAI A,B,E,F,I Yes 00159662 No
84—2 — Structural Chromosomal TGAI A,B,E,F,I No Yes9/ 12 Months
Aberration
84—4 — Other Cenotoxic Effects TCAI AB,E,F,I No YeslO/ 12 Months
—67—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Data Requirement Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Substance
Patterns
Have
Data?
Citation
Data be
Submitted?
for
Submission
§158.135 Toxicology — Continued
SPECIAL TESTING
85—1 — General Metabolism PAL or PAIRA A,B,E,FJI Partially 00159964 Reservedllf
85—2 — Dermal Penetration Choice N/A No No3/
86—1 — Domestic Animal Choice N/A No No12/
Safety
—68—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
§158.135 Toxicology — Continued
1/ This chemical is not an organophosphorous compound nor does it produce cholinesterase inhibition.
2/ 90—day range finding studies should be carried out to determine dosage and target organs prior to chronic studies.
3/ Not required because there is no expected dermal exposure from the registered patterns of use.
4/ Neurological effects should be emphasized in carrying out methyl bromide studies by any route of exposure or
duration.
5/ Testing in the rabbit is required because this species appears to be very sensitive to the effects of methyl bromide.
6/ Because tolerances are required, this study should be conducted by gavage.
7/ These data are being developed to satisfy the requirements of a Data Call In Notice dated July 2, 1981 for
methyl bromide. As required by that notice, the data must be submitted by January 31, 1987.
8/ An inhalation reproductive study has been received by the Agency and is currently under review.
9/ Bone marrow and sister chromatid exchange tests using appropriate dose levels are required.
10/ Unscheduled DNA synthesis using rat hepatocytes and a test to determine the effects on germ cells are required.
11/ If toxicology and residue data indicate residues of toxicological significance, these studies will be required.
12/ Based on the registered patterns of use, there Is no expected exposure to domestic animals.
—69—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METhYL BROMIDE
Data Requirement Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Substance
Patterns
Have
Data?
Citation
Data be
Submitted?
for
Submission
§158.140 Reentry Protection
132—1 — Foliar Dissipation TEP N/A No No!!
132—1 — Soil Dissipation TEP A,B No Yes 27 Months
133—3 — Dermal Exposure TEP N/A No No2/
133—4 — Inhalation Exposure TEP A,B,E,F,I Partially 00159648,00159649 Yes3/
00159651,00159652
00159653,00159654
001 59655,00159656
00159657, 00159658
001 59659, 001 59660
00159661
1/ Not required because there are no foliar uses.
2/ Not required because there is no expected dermal exposure from the use of methyl bromide.
3/ These data have been received by the Agency and are currently under review.
—70—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Data Requirement Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Substance
Patterns
Have
Data?
Citation
Data be
Submitted?
for
Submission
§158.145 Wildlife and
Aquatic Organisms
AVIAN AND MAMMALIAN TESTING
71—1 — Acute Avian Oral Toxicity TGAI N/A No No!/
71—2 — Avian Subacute Dietary TGAI N/A No
Toxicity
— Upland Game Bird, and No!!
— Waterfowl No!!
71-3 — Wild Mammal Toxicity TGAI N/A No No2/
71—4 — Avian Reproduction TGAI N/A No
— Upland Game Bird, and No2/
— Waterfowl No2/
71—5 — SimuLated Field Testing TEP N/A No
— Mammals, and No2/
— Birds No2/
— Actual Field Testing TEP N/A No
— Mammals, and No2/
- Birds No2/
—71—
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TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
Data Requirement Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Substance
Patterns
Have
Data?
Citation
Data be
Submitted?
for
Submission
§158. 145 Wildlife and
uatic Organisms — Continued
AQUATIC ORGANISM TESTING
72—I — Freshwater Fish Toxicity TCAI A,B No
— Coidwater Fish Species, No /
and
— Warmwater Fish Species Reserved3/4/
72—2 — Acute Toxicity to TGAI A,B No Reserved3/
Freshwater Invertebrates
72—3 — Acute Toxicity to TGAI N/A No
Estuarine and Marine
Organisms
— Fish NoZ/
— Mollusk No2/
— Shrimp No2/
72—4 — Fish Early Life Stage, TGAI N/A No No /
and
— Aquatic Invertebrate No /
Life—Cycle
72—5 — Fish — Life—Cycle TCAI N/A No No2/
—72—
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METFIYL BROMIDE
Data Requirement Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Substance
Patterns
have
Data?
Citation
Data be
Submitted?
for
Submission
§158.145 Wildlife and
Aquatic Organisms — Continued
72—6 — Aquatic Organism TGAI, PAl OR N/A No
Accumulation Degradation
Product
— Crustacean No2/
- Fish No2/
— Insect Nymph No2/
— Mollusk No2/
72—7 — Simulated Field Testing TEP N/A No No2/
— Aquatic Organisms
— Actual Field Testing No2/
— Aquatic Organisms
—73—
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR METHYL BROMIDE
§158. 145 Wildlife and Aquatic Organisms — Continued
!/ Not required because the product is a gas at room temperature.
2/ Not required because there is no expected exposure from the registered patterns of use.
3/ Based on the registered patterns of use, surface contamination from the use of methyl bromide is unlikely.
Development of this data is therefore contingent upon a determination of whether or not groundwater contamination
from the outdoor uses of methyl bromide is established 0
4/ Bluegill sunfish should be used. A warm water species was selected because methyl bromide is used mainly in areas
with warm waters.
—74—
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING—USE PRODUCTS CONTAINING METHYL BROMIDE
Data Requirement Test
Use
Does
EPA
Bibliographic
Must
Additional
Time Frame
Substance
Patterns
Have
Data?
Cltatlon!/
Data
be
for
Submitted?
Submission
All
All
All
N/A
N/A
N/A
Yes
Yes
Yes
12 Months
12 Months
12 Months
6 Months
6 Months
6 Months
§158.120 Product Chemistry
Product Identity:
61—1 — Product Identity and MP
Disclosure of
Ingredients
61—2 — Description of Beginning MP
Materials and
Manufacturing Process
61—3 — Discussion of Formation MP
of Impurities
Analysis and Certification of Product
Ingredients
62—1 — Preliminary Analysis MP
62—2 — Certification of Limits MP
62—3 — Analytical Methods to HP
Verify Certified Limit
Physical and Chemical Characteristics
63—2 — Color MP
63—3 — Physical State MP
63—4 — Odor HP
All
N/A
Yes
6
Months
All
N/A
Yes
6
Months
All
N/A
Yes
6
Months
All
N/A
Yes
All
N/A
Yes
All
Yes
—75—
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING—USE PRODUCTS CONTAINING METHYL BROMIDE
Data Requirement
Test
Substance
Use
Pattern8
Does
Have
EPA
Data?
Btbl lographic
Cttatlon!/
Must
Data
Additional
be
Time Frame
for
Submitted?
Submission
§158.120 Product Chemistry (Continued)
Physical and Chemical Characteristics
(Continued)
63—7 — Density, Bulk Density, or MP All N/A Yes 6 Months
Specific Gravity
63—12 - pH NP All N/A Yes 6 Months
63—14 — Oxidizing or Reducing 4P All N/A Yes 6 Months
Action
63—15 — Flammability MP All N/A No2/
63—16 — Explodability MP All N/A Yes 6 Months
63—17 — Storage Stability MP All N/A Yes 15 Months
63—18 — Viscosity NP All N/A No3/
63—19 — Miscibility MP All N/A No3/
63—20 — Corrosion Characteristics MP All N/A Yes 6 Months
1/ Not applicable. Although product chemistry data may have been submitted In the past, the Agency has determined that
these data must be resubmitted for each manufacturing use product. New requirements have been introduced and
previously submitted data must be updated. Therefore bibliographic citations for the old data are not applicable.
2/ Not required because the product does not contain combustible liquids under atmo pheric conditions.
3/ Not required because the product is a gas at room temperature.
—76—
-------
TABLE B
PRODUCT SPECIFIC DATA REQUIREMENTS FOR MANUFACTURING—USE PRODUCTS CONTAINING METHYL BROMIDE
Data Requirement Test Use Does EPA Bibliographic Must Additional Time Frame
Substance Patterns Have Data? Citation Data be for
Submitted? Submission
§ 158. 135 Toxicology
ACUTE TESTING
81—1 — Acute Oral Toxicity — Rat
81—2 — Acute Dermal Toxicity
— Rabbit
81—3 — Acute Inhalation Toxicity
- Rat
81—4 — Primary Eye
Irritation — Rabbit
81—5 — Primary Dermal
Irritation — Rabbit
81—6 — Dermal Sensitization —
Guinea Pig
MP
MP
HP
HP
MP
HP
A,B,E,F, I
A,B,E,F,I
A,B,E,FI
A,B,E,F 1 I
A,B,E,F, I
A,B,E,F, 1
Yes 00159664 No
Yes 00159664 No
Yes 00159664
No
Yes 00159664 No
Yes 00159664 No
Yes 00159664 No
—77—
-------
LABEL CONTENTS
40 CFR 162.10 requires that certain specific labeling
statements appear at certain locations on the label. This
is referred to as format labeling . Specific label items listed
below are keyed to the table at the end of this Appendix.
Item 1. PRODUCT NAME — The name, brand or trademark is
required to be located on the front panel, preferably centered
in the upper part of the panel. The name of a product will
not be accepted if it is false or misleading.
Item 2. COMPANY NAME AND ADDRESS — The name and address
of the registrant or distributor is required on the label.
The name and address should preferably be located at the
bottom of the front panel or at the end of the label text.
Item 3. NET CONTENTS — A net contents statement is
required on all labels or on the container of the pesticide.
The preferred location is the bottom of the front panel
immediately above the company name and address, or at the end
of the label text. The net contents must be ecpressed in the
largest suitable unit, e.g., “1 pound 10 ounces” rather than
“26 ounces.” In addition to English units, net contents may
be expressed in metric units. [ 40 CFR 162.10(d)]
Item 4. EPA REGISTRATION NUMBER — The registration
number assigned to the pesticide product must appear on the
label, preceded by the phrase “EPA Registration No.,” or EPA
Reg. No.” The registration number must be set in type of a
size and style similar to other print on that part of the
label on which it appears and must run parallel to it. The
registration number and the required identifying phrase must
not appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Agency.
[ 40 CFR l& 2 .10(e)]
Item 5. EPA ESTABLISHMENT NUMBER — The EPA establishment
number, preceded by the phrase “EPA Est.” is the final estab-
lishment at which the product was produced, and may appear
in any suitable location on the label or immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment number on the immediate
container cannot be clearly read through such wrapper or container.
[ 40 CFR 162.10(f)]
Item 6A. INGREDIENTS STATEMENT — An ingredients statement
is required on the front panel. The ingredients statement must
contain the name and percentage by weight of each active ingredient
and the total percentage by weight of- all inert ingredients.
The preferred location is Immediately below the product name.
The ingredients statement must run parallel with, and be clearly
distinguished from, other text on the panel. It must not be
placed in the body of other text. [ 40 CFR 1 62 .lO(g)]
—78—
-------
Item 68. POUNDS PER GALLON STATEMENT — For liquid agricul—
tural formulations, the pounds per gallon of active ingredient
must be indicated on the label.
Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS — Front panel
precautionary statements must be grouped together, preferably
within a block outline. The table below shows the minimum type
size requirements for various size labels.
Size of Label Signal Word “Keep Out of Reach
on Front Panel Minimum Type Size of Children”
in Square Inches All Capitals Minimum Type Size
5 and under 6 point 6 point
above 5 to 10 10 point 6 point
above 10 to 15 12 point 8 point
above 15 to 30 14 point 10 point
over 30 18 point 12 point
Item 7A. CHILD HAZARD WARNING STATEMENT - The statement
“Keep Out of Reach of Children” must be located on the front
panel above the signal word except where contact with children
during distribution or use is unlikely. [ 40 CFR 162.lO(h)(1)(ii)]
Item 78. SIGNAL WORD — The signal word (DANGER, WARNING,
or CAUTION) is required on the front panel immediately below
the child hazard warning statement. [ 40 CFR 162.10 (h)(l)(i)1
ttem 7C. SKULL & CROSSBONES AND WORD “POISON” — On products
assigned a toxicity Category I on the basis of oral, dermal,
or inhalation toxicity, the word “Poison” shall appear on the
label in red on a background of dtstinctly contrasting color and
the skull and crossbones shall appear in immediate proximity to
the word POISON. [ 40 CFR 162.1O(h)(l)(i)]
Item 70. STATEMENT OF PRACTICAL TREATMENT - A statement
of practical treatment (first aid or other) shall appear on
the label of pesticide products in toxicity Categories I,
II, and III. [ 40 CFR l62.l0(h)(l)(iii)]
Item 7E. REFERRAL STATEMENT — The statement “See Side
(or Back) Panel for Additional Precautionary Statements” is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
[ 40 CFR 162.lO(h)(l)(iii)]
Item 8. SIDE/BACK PANEL PRECAUTIONARY LABELING — The
precautionary statements listed below must appear together
on the label under the heading “PRECAUTIONARY STATEMENTS.”
The preferred location is at the top of the side or back
panel preceding the directions for use, and it is preferred
that these statements be surrounded by a block outline. Each
of the three hazard warning statements must be headed by the
appropriate hazard title. [ 40 CFR l62.lO(h)(2)J.
—79—
-------
Item 8A. HAZARD TO HUMANS AND DOMESTIC ANIMALS — Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route(s) of exposure and the precautions to be taken to avoid
accident, injury or damage. [ 40 CFR l62.lO(h)(2)(i)1
Item 88. ENVIRONMENTAL HAZARD — Where a hazard exists to
non—target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, injury, or damage. [ 40 CFR l62.lO(h)(2)(ii)]
Item 8C. PHYSICAL OR CHEMICAL HAZARD — FLAMMABILITY
Precautionary statements relating to flammability of a product
are required to appear on the label if it meets the criteria
in the PHYS/CHEM Labeling Appendix. The requirement is
based on the results of the flashpoint determinations and
flame extension tests required to be submitted for all products.
These statements are to be located in the side/back panel
precautionary statements section, preceded by the heading
“Physical/Chemical Hazards.” Note that no signal word is
used in conjunction with the flammability statements.
Item 9A. RESTRICTED USE CLASSIFICATION — FIFRA sec. 3(d)
requires that all pesticide formulations/uses be classified
for either general or restricted use. Products classified
for restricted use may be limited to use by certified applicators
or persons under their direct supervision (or may be subject
to other restrictions that may be imposed by regulation).
In the Registration Standard, the Agency has (1) indicated
certain formulations/uses are to be restricted (Section IV
indicates why the product has been classified for restricted
use); or (2) reserved any classification decision until
appropriate data are submitted.
The Regulatory Position and Rationale states whether
products containing this active ingredient are classified
for restricted use. If they are restricted the draft label(s)
submitted to the Agency as part of your application must
reflect this determination (see below).
If you do not believe that your product should be classified
for restricted use, you must submit any information and
rationale with your application for reregistration. During
the Agency’s review of your application, your proposed classi-
fication determination will be evaluated in accordance with
the provisions of 40 CFR. 162.11(c). You will be notified of
the Agency’s classification decision.
—80—
-------
Classification Labeling Requirements
If your product has been classified for restricted use,
the following label requirements apply:
1. All uses restricted.
a. The statement “Restricted Use Pesticide” must
appear at the top of the front panel of the label. The
statement must be set in type of the same minimum size
as required for human hazard signal word (see table in 40
CFR 162. 10(h) (1 )(iv)
b. Directly below this statement on the front panel,
a summary statement of the terms of restriction must
appear (including the reasons for restriction if specified
in Section I). If use is restricted to certified applicators,
the following statement is required: “For retail sale
to and use only by Certified Applicators or persons
under their direct supervision and only for those uses
covered by the Certified Applicator’s Certification.”
2. Some but not all uses restricted. If the Regulatory
Position and Rationale states that some uses are classified
for restricted use, and som e are unclassified, several courses
of action are available:
a. You may label the product for Restricted use.
If you do so, you may include on the label uses that
are unrestricted, but you may not distinguish them
on the label as being unrestricted.
b. You may delete all restricted uses from your
label and submit draft labeling bearing only unrestricted
uses.
c. You may “split” your registration, i.e., register
two separate products with identical formulations, one
bearing only unrestricted uses, and the other bearing
restricted uses. To do so, submit two applications for
reregistration, each containing all forms and necessary
labels. Both applications should be submitted simul-
taneously. Note that the products will be assigned
separate registration numbers.
Item 9B. MISUSE STATEMENT — All products must bear the
misuse statement, “It is a violation of Federal law to use
this product in a manner inconsistent with its labeling.”
This statement appears at the beginning of the directions
for use, directly beneath the heading of that section.
—81—
-------
Item 1OA. REENTRY STATEMENT — If a reentry interval
has been established by the Agency, it must be included on
the label. Additional worker protection statements may be
required in accordance with PR Notice 83—2, March 29, 1983.
Item lOB. STORAGE AND DISPOSAL BLOCK — All labels are
required to bear storage and disposal statements. These
statements are developed for specific containers, sizes, and
chemical content. These instructions must be grouped and
appear under the heading “Storage and Disposal” in the directions
for use. This heading must be set in the same type sizes as
required for the child hazard warning. Refer to Appendix tI,
STOR, PEST/DIS, and CONT/DIS to determine the storage and
disposal instructions appropriate for your products.
Item 1OC. DtRECTIONS FOR USE — Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide. When followed, directions must be adequate to
protect the public from fraud and from personal injury and to
prevent unreasonable adverse effects on the environment.
[ 40 CFR 162.10]
COLLATERAL LABELING
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, or other written or graphic printed matter which is
referred to on the label or which is to accompany the product
are termed collateral labeling. Such labeling may not bear
claims or representations that differ in substance from those
accepted in connection with registration of the product. It
should be made part of the response to this notice and submitted
for review.
—82—
-------
LABELING REQUIREMENTS OF TUE FIFRA, AS AMENDED
ITEM
LABEL ELEMENT
APPLICABILITY
OF REQUIREMENT
PLACEMENT ON LABEL
COMMENTS
REQUIRED
PREFERRED
1
Product name
All products
Front panel
Center front
panel
2
Company name
and address
All products
None
Bottom front
panel or end
of label text
If registrant is not the producer, must
be qualif ted by “Packed for . . .,‘
“Distributed by. . ., “ etc.
3
Net contents
All products
None
Bottom front
panel or end
of label text
May be in metric units in addition to
U.S. units
4
EPA Reg. No.
All products
None
Front panel
Must be in similar type size and run
parallel_to_other_type.
5
EPA Est. No.
All products
None
Front panel,
immediateLy
before or
following
Reg._No.
May appear on the container instead of
the label.
6A
Ingredients
statement
All products
Front panel
Immediately
following
product_name
Text must run parallel with other text
on the panel.
6B
Pounds/gallon
statement
Liquid products
where dosage
given as lbs.
al/unit area
Front panel
Directly below
the main
ingredients
statement
7
Front panel
precautionary
statements
All products
Front panel
All front panel precautionary statements
must be grouped together, preferably
blocked.
7A
Keep Out of Reach
of Children
(Child hazard
warning)
All products
Front panel
Above signal
word
Note type size requirements.
7B
Signal word
All products
Front panel
Immediately
below child
hazard
warning
Note type size requirements.
—83—
-------
ITEM
.
LABEL ELEMENT
APPLICABILITY
OF REQUIREMENT
PLACEMENT ON LABEL
COMMENTS
REQUIRED
PREFERRED
7C
Skull & cross—
bones and word
POISON (in red)
All products
which are Cat—
egory I based
on oral, der—
mal, or inhala-
tion_toxicity
Front panel
Both in close
proximity to
signal word
7D
Statement of
Practical
Treatment or
First Aid
All products
In Categories
I, II, and III
Category I:
Front panel
unless refer—
ral statement
is used.
Others:
Grouped with
side panel
precautionary
statements.
Front panel
for all.
7E
Referral
statement
All products
where pre-
cautionary
labeling
appears on
other than
front_panel.
Front panel
8
Side/back panel
precautionary
statements
All products
None
Top or side
of back panel
preceding
directions
for_use
Must be grouped under the headings In
8A, 8B, and 8C; preferably blocked.
8A
Hazards to
humans and
domestic
anima 18
All products
in Categories
I, II, and III
None
Same as above
Must be preceded by appropriate signal
word.
8B
Environmental
hazards
All products
None
Same as above
Environmental hazards include bee
caution where applicable.
—84-
-------
ITEM
LABEL ELEMENT
APPLICABILITY
OF REQUIREMENT
PLACEMENT ON LABEL
COMMENTS
REQUIRED
PREFERRED
8C
Physical or
chemical
hazards
All pressurized
products, others
with flash
points under
150°F
None
Same as above
Refer to Appendix II guide
PHYS/CHEM
9A
Restricted
block
All restricted
products
Top center
of front
panel
Preferably
blocked
Includes a statement of the terms of
restriction. The words “RESTRICTED USE
PESTICIDE must be same type size as
signal word.
9B
Misuse
statement
All products
Immediately
following
heading of
directions
for use
Required statement is:
It is a violation of Federal law
to use this product in a manner
inconsistent with its labeling.”
lOA
Reentry
statement
PR Notice 83—2
or as determined
by the Agency
In the
directions
for use
Immediately
after misuse
statement
lOB
Storage and
disposal block
All products
In the
directtons
for use
Immediately
before
specific
directions
for use or
at the end of
directions
for_use
Must be set apart and clearly distin—
guishable from from other directions
for use.
Refer to Appendix It guides STOR,
CONT/DIS, and PEST/DIS for further
information and required statements.
1OC
Directions
for_use
All products
None
None
May be in metric as well as U.S. units
—85—
-------
* 162.10 TItle 4O—P .t.dion of Envhonm.n9
0162.10 LabelIng requlrtmenta.
(a) Generc2—(1) Contei t of the
labeL Every pesticide products shall
bear a label containing the ln.forma•
tion specified by the Act and the regu-
lations th this Part The contents of a
label must show clearly and promi-
nently the fol]owlnr
(1) The name, brand, or trademark
under which the product is sold as pre-
scribed in paragraph (b) of this sec-
tion:
(11) The name and address of the
producer, registrant, or person for
—86—
-------
Q opt.r I_EnvI,11m11%taI PTO$.CIIOn Ag.ncy
162.10
whom produced as prescribed In para-
graph Cc) of this section;
(U I) The net contents as prescribed
In paragraPh (d) of this section:
(Iv) The product registration
number as prescribed In paragraph (e)
of this sectiOn;
(v) The producing establishment
number as prescribed in paragraph Ct)
of this section;
(vi) An ingredient statement as pre-
scribed In paragraph (g) of this sec-
tion:
(vii) Warning or precautionarY state-
ments as prescribed In paragraph (h)
of this section;
(viii) The directions for use as pre-
scribed in paragraph (ii of this section;
and
(Lx) The use clasatficatlOn(S) as pre-
scribed In paragraph (1) of this section.
(2) ProminenCe and le fbilUV. (1) All
words, statements, graphic representa-
tions. designs or other information re-
quired on the labeling by the Act or
the regulations in this part must be
clearly legible to a person with normal
vIsIofl. and must be placed with such
conspicuousness (as compared with
other words. statements, designs, or
graphic matter on the labeling) and
expressed in such terms as to render it
likely to be read and understood by
the ordinary Individual under custom-
ary conditions of purchase and use.
(II) All required label text must
(A) Be set In 6-point or larger type:
(B) Appear on a clear contrasting
background; and
(C) Not be obscured or crowded.
(3) Lan g’jage to be used. All required
label or labeling text shall appear In
the English language. However, the
Agency may require or the applicant
may propose additional text in other
languages as is considered necessary to
protect the public. When additional
text in another language Is necessary,
all labeling requirements will be ap-
plied equally to both the English and
other-language versions of the label-
ing.
(4) Placement of Label—(i) General.
The label shall appear on or be secure-
ly attached to the lxrunediate contain-
er of the pesticide product. For pur•
poses of this Section. and the mis-
branding provisions of the Act. “se-
curely attached” shall mean that a
label can reasonably be expected to
remain affixed during the foreseeable
conditions and period of use. If the Im-
mediate container Is enclosed within a
wrapper or outside container through
which the label cannot be clearly read.
the label must also be securely at-
tached to such outside wrapper or con-
tainer. if it is a part of the package as
customarily distributed or sold.
(II) Tank can and other bulk con-
ta(nera .—(A) Transportation. While a
pesticide product is In transit, the ap-
propriate provisions of 49 CFR Parts
170-189. concerning the transportation
of hazardous materials, and sped! teal-
ly those provisions concerning the la-
beling. marking and placarding of haz-
ardous materials and the vehicles car-
rying them, define the basic Federal
requirements. In addition, when any
registered pesticide product is trans
ported in a tank car, tank truck or
other mobile or portable bulk contain-
er, a copy of the accepted label must
be attached to the shipping papers.
and left with the consignee at the time
of delivery.
(B) Storage. When pesticide prod-
ucts are stored in bulk containers.
whether mobile or stationary, which
revI’ aIn in the custody of the user, a
copy of the label of labeling. including
all appropriate directions for use. &hall
be securely attached to the container
In the Immediate vicinity of the dis-
charge control valve.
(5) FaLse or ,ntsleczdtng statements.
Pursuant to section 2(QX1XA) of the
Act, a pesticide or a device declared
subject to the Act pur uaflt to
162.15, is misbranded If its labeling is
false or ml3lea1 11g In any particular
including both pesticidal and non-pea-
ticidal Claims . Examples of statements
or representations in the labeling
which constitute misbranding Include:
(I) A false or misleading statement
concerning the composition of the
product:
(II) A false or misleading statement
concerning the effectiveness of the
product as a pesticide or device:
(iii) A false or mbleadjng statement
about the value of the product for
purposes other than as a pesticide or
device;
(iv) A false or misleading comparison
with other pesticides or dfvlceS
—87—
-------
§ 162.10
Titi. 40—Protection of Environment
(v) Any statement directly or indi-
rectly implying that the pesticide or
device Is recommended or endorsed by
any agency of the Federal Govern-
ment.
(vi) The name of a pesticide which
contains two or more principal active
ingredients IS the name suggests one
or more but not all such principal
active ingred ients even though the
names of the other Ingredients are
stated elsewhere in the labeling;
(vii) A true statement used in such a
way as to give a false or misleading Im-
pression to the purchaser,
(viii) Label disclaimers which negate
or detract from labeling statements re-
quired under the Act and these regula-
tions:
(ix) CInIrn as to the safety of the
pesticide or Its ingredients, including
statements such as “safe,” “nonpoison-
ous,” •‘nonlnjurlous,” “harmless” or
“nontoxic to humans and pets’ with
or without such a qualifying phrase as
“when used as directed”; and
(x) Non-numerical and/or compara-
tive statements on the safety of the
product, including but not limited to:
(A) “Contains all natural ingredi-
ents”;
(B) “Among the least toxic them.!-
cals known”
(C) “Pollution approved”
(6) Fins.! printed labeling. (I) Except
as provided In paragraph (aX6XI1) of
this section, fInal printed Labeling
must be submitted and accepted prior
to registration. However, final printed
labeling need not be submitted until
draft label texts have been provision-
ally accepted by the Agency.
(11) Clearly legible reproductions or
photo reductions will be accepted for
unusual labels such as those silk-
screened directly onto glass or metal
containers or large bag or drum labels.
Such reproductions must be of micro-
film reproduction quality.
(b) Name, brnrid, or trademark. (1)
The name, brand, or trademark under
which the pesticide product is sold
shall appear on the front panel of the
label.
(2) No name, brand, or trademark
may appear on the label which:
(I) Is false or misleading, or
(II) Has not been approved by the
Administrator through registration or
supplemental registration as an addi-
tional name pursuant tO 162 6(b)(4).
(c) Name and address of producer,
registrant, or person for whom pro-
duced. An unqualified name arid ad-
dre’-.s given on the label shall be con-
sidi ‘ed as the name and address of the
pr ucer. If the registrant’s name ap-
pears on the label and the registrant is
not the producer, or if the name of the
person for whom the pesticide was
produced appears on the label, It must
be qualified by appropriate wording
such as “Packed for 0 ,“ “Distribut-
edby • ,“or”Soldby • “toshow
that the name is not that of the pro-
ducer.
(d) Net weight or measure of con-
tents. (1) The net weight or measure
of content shall be exclusive of wrap-
pers or other materials and shall be
the average content unless explicitly
stated as a minimum quantity.
(2) If the pesticide is a liquid, the
net content statement shall be In
terms of liquid measure at 68’ F (20’C)
and shall be expressed in conventional
American units of fluid ounces, pints,
quarts, and gallons.
(3) If the pesticide Is solid or semi-
solid, viscous or pressurized, or is a
mixture of liquid and solid, the net
content statement shall be In terms of
weight expressed as avoirdupois
pounds and ounces.
(4) In all cases, net content shall be
stated In terms of the largest suitable
units, I.e.. “1 pound 10 ounces” rather
than “26 ounces.”
(5) In addition to the required units
specified, net content may be ex-
pressed in metric units.
(6) VarIation above minimum con-
tent or around an average is permlssl
ble only to the extent that It repre-
sents deviation unavoidable in good
manufacturing practice. Variation
below a stated minimum Is not permit-
ted. In no case shall the average con-
tent of the packages In a shipment fall
below the stated average content.
(e) Product registration number.
The registration number assigned to
the pesticide product at the time of
registration shall appear on the label,
preceded by the phrase “EPA Regis-
tration No.,” or the phrase “EPA Reg.
No.” The registration number shall be
set in type of a size and style &n’ i1 r to
—88—
-------
Chapter I—Environmental Protection Agency
other print on that part of the label
on which it appears and shall run par-
allel to It. The registration number
and the required Identifying phrase
shall not appear in such a manner as
to suggest or Imply recommendation
or endorsement of the product by the
Agency.
(f) Producing estabhshmenti regis-
trution number. The producing estab-
lishment registration number preced-
ed by the phrase “EPA Est.”, of the
final establishment at which the prod-
uct was produced may appear in any
suitable location on the label or Imme-
diate container. It must appear on the
wrapper or outside container of the
package if the EPA establishment reg-
istration number on the Ixnmedlate
container cannot be clearly read
through such wrapper or container.
(g) Ingredient statement—Il) Gener-
aL The label of each pesticide product
must bear a statement which contains
the name and percentage by weight of
each active ingredient, the total per-
centage by weight of all inert ingredi-
ents: and if the pesticide contains ar-
senic in any form, a statement of the
percentages of total and water-soluble
arsenic calculated as elemental ar-
senic. The active ingredients must be
designated by the term “active ingredi-
ents” and the inert ingredients by the
term “inert Ingredients.” or the singu-
lar forms of these terms when appro-
priate. Both terms shall be in the
same type size, be aligned to the same
margin and be equally prominent. The
statement “Inert Ingredients, none” Is
not required for pesticides which con-
talxi 100 percent active ingredients.
Unless the Ingredient statement Is a
complete analysis of the pesticide, the
term “analysis” shall not be used as a
heading for the ingredient statement.
(2) PositIon of ingredient statement.
(i) The ingredier.t statement Is nor-
mally required on the front panel of
the label. If there Is an outside con-
tainer or wrapper through which the
ingredient statement cannot be clearly
read, the ingredient statement must
also appear on such outside container
or wrapper. If the size or form of the
package makes it impracticable to
place the ingredient statement on the
front panel of the label, permission
§ 162.10
may be granted for the ingredient
statement to appear elsewhere.
(ii) The text of the Ingredient state-
ment must run parallel with other
text on the panel on which it appears,
and must be clearly distinguishable
from and must not be placed in the
body of other text.
(3) Names to be used In ingredient
statement. The name used for each in-
gredient shall be the accepted
common name, if there Is one, fol-
lowed by the chemical name. The
common name may be used alone only
if it Is well known. If no common name
has been established, the chemical
name alone shall be used. In no case
will the use of a trademark or proprie-
tary name be permitted unless such
name has been accepted as a common
name by the Administrator under the
authority of Section 25(cX8).
(4) Statements of percentages- The
percentages of ingredients shall be
stated in terms of weight-to-weight.
The sum of percentages of the active
and the inert ingredients shall be 10O
Percentages shall not be expressed by
a range of values such as “22 -25% ?’ If
the uses of the pesticide product are
expressed as weight of active ingredi-
ent per unit area, a statement of the
weight of active Ingredient per unit
volume of the pesticide formulation
shall also appear in the ingredient
statement.
(5) Accurv.cy stated percentages,
The percentages given shall be as pre-
cise as possible reflecting good manu-
facturing practice. U there may be un-
avoidable variation between manufac-
turing batches, the value stated for
each active Ingredient shall be the
lowest percentage which may be
present.
(6) DeterIoration. Pesticides which
change In chemical composition sig-
nificantly must meet the following la-
beling requlrementa
U) In cases where it is determined
that a pesticide formulation changes
chemical composition significantly.
the product must bear the following
statement In a prominent position on
the label. “Not for sale or use after
Idate].”
(II) The product must meet all label
claims up to the expiration time indi-
cated on the label.
—89--
-------
§ 162.10
Title 40—Protection of Environment
(7) inert ingredients. The Adminis-
trator may require the name of any
Inert ingredient(s) to be listed In the
Ingredient statement 11 he determines
that such ingredient (s) may pose a
hazard to man or the environment.
(h) Warnings and precautionary
statements. Required warnings and
precautionary statements concerning
the general areas of toxicological
hazard including hn, .rd to children.
environmental hazard, and physical or
chemical hnrard fall into two oups;
those required on the front panel of
(I) Human hazard signal woni—(A)
Toxicity Category L AU pesticide prod-
ucts meeting the criteria of Toxicity
Category I shall bear on the front
panel the signal word “Danger.” In ad-
dition if the product was assigned to
Toxicity Category I on the basis of its
oral, Inhalation or derma] toxicity (as
distinct from skin and eye local ef-
fects) the word “Poison” shall appear
In red on a background of distinctly
contrasting color and the skull and
crossbones shall appear in immediate
proximity to the word “poison.”
(B) Toxicity Category II. AU pesti-
cide products meeting the criteria of
Toxicity Category II shall bear on the
front panel the signal word “Warn-
ing-’.
(C) Toxicity Category ilL Al] pesti-
dde products meeting the criteria of
Toxicity Category UI shall bear on
the front panel the signal word “Cau-
tion.”
(D) Toxicity Category IV. Al] pesti-
cide products meeting the criteria of
Toxicity Category l v shall bear on the
front panel the signal word “Caution,”
the labeling and those which may
appear elsewhere. Specific require-
ments concerning content, placement.
type size, and prominence are given
below.
(1) Required front panel statement.s
With the exception of the child
hazard warning statement, the text re-
quired on the front panel of the label
Is determined by the Toxicity Catego-
ry of the pesticide. The category is as-
signed on the basis of the highest
h .d shown by any of the indicators
In the table below:
CE) Use of signal words. Use of any
signal word(s) associated with a higher
Toxicity Category is not permitted
except when the Agency determines
that such labeling is necessary to pre-
vent unreasonable adverse effects on
man or the environment. In no case
shall more than one human hazard
signal word appear on the front panel
of a label.
(I I) Child hazard warning. Every pes-
ticide product label shall bear on the
front panel the statement “keep out of
reach of children.” Only in cases
where the likelihood of contact with
children during distribution, market-
ing. storage or use is demonstrated by
the applicant to be extremely remote,
or if the nature of the pesticide is such
that it Is approved for use on infants
or small children. may the Administra-
tor waive this requirement.
(ill) Statement of practical treat-
ment— (A) Toxicity Category I. A
statement of practical treatment (first
aid or other) shall appear on the front
panel of the label of all pesticides fall-
ing Into Toxicity Category I on the
r
To ?y t $
I
I I
III
Iv
C’ 1.0..
up w 50
mp/kQ
From 50 avu 500 r /k0
From 500 Ovu 5000 iT /
k
Groatec than 5000 m /
k
IC . . ..
up w mig .2
nç a__
From 2 Ovu 2 irçfW
From 2 evu 20 nç/
Gcuatii th 20 mgI
O.’i LD.,_ —
up . 200
Ivç/kg
From 200 Ovu 2000 —
From 2.000 Uth& 20000
GivEr thri 20000
I,. øIsc
Cci’o.vs om
vEy fbi rs IEII
wi 7 d. a .
C op
r.v Ws Vwi 7
ys gthaxn
7 yv
No ns& opsoty
iI tOI rriur1 Ie
WIOVn 7 yv
No rnauon
S i sf$sc
C vc. e —— - -
S.v.r. wn ia it 72
,mIn.
rate umsuon ii 72
-
MId s or%t irutatior at
72 tom
—90—
-------
Chopter I—Environmental Protection Ag.ncy
basis of oral. Inhalation or derrnal tox-
icity. The Agency may. however.
permit reasonable variations in the
placement of the statement of practi-
cal treatment is some reference such
as “See statement of practical treat-
ment on back panel” appears on the
front panel near the word “Poison”
and the skull arid cro bones.
(B) Other toxzctty categories. The
statement of practical treatment is not
required on the front panel except as
described in paragraph (h)(1)(llfl(A) of
this section. The applicant may, how-
ever. include such a front panel state-
ment at his option. Statements of
practical treatment are, however, re-
quired eLsewhere on the label in
accord with paragraph (h)(2) of this
section If they do not appear on the
front panel.
(iv) Placement and prominence. All
the require front panel warning state-
ments shall be grouped together on
the label, and shall appear with suffi-
cient prominence relative to other
front panel text and graphic material
to make them unlikely to be over-
looked under customary conditions of
purchase and use. The following table
shows the rninlrnum type size require-
ments for the front panel warning
statements on various sizes of labels
(ii) Environmental hazards. Where a
hazard exists to non target organisms
excluding humans and domestic ani-
mals. precautionary statements are re-
quired stating the nature of the
§ 162.10
S . of libel front pen vi u e
gc ,
Rsoiasd
.
01 roiof I of
c
5 i dividu r ..
Ab oviStolO
Abo ve l Otoi5 ._
AboveIStO3 O
-.
•
10
12
*4
18
a
•
8
*0
*2
(2) Other required warnings and pre-
cautior&ai’j statements. The warnings
and precautionary statements as re-
quired below shall appear together on
the label under the general heading
“Precautionary Statements” and
under appropriate subheadings of
‘Hazard to Humans and Domestic Ani-
mals.” “Environmental Hazard” and
“Physical or Chemical Hazard.”
(1) Hazard to humans and domestic
animaLs. (A) Where a hazard exists to
humans or domestic aninimig, precau-
tionary statements are required mdi-
cating the particular hazard, the
route(s) of exposure and the precau-
tions to be taken to avoid accident.
Injury or th ntage . The precautionary
paragraph shall be imxned .Iately pre-
ceded by the appropriate hazard signal
word.
(B) The following table depicts typi-
cal precautionary statements. These
statements must be modified or ex-
panded to reflect specific hazards-
hazard and the appropriate precau-
tions to avoid potential accident,
Injury or damage. Examples of the
hazard statements and the circum-
U
I II
Iv
Tciioty
category
P!ecsinoiwy si&...nhe by towip CItIQOFy
iJ or dwvt J to fy
Skel Wid epe IOCII 01t
Fatal (poiso ’ ts) d Iwallowed (awialed or aLe,It.d
Conovve e es eye id ti dIlliage (a’ $*r
Uvorigh ai3 O i 1 u iths v cp ( a’ vy
rioiborl Do rt go vi cm t*. or on
nvitl Do , l gel vi eywe on *11. or cm dorwig
doUwig WW OQ S$ a’ I ICI al ld id
(Front parS s Iament 01 .cbC.l Usstmsnt r.-
gloves .lIsn tw Ig. Nw ’ a’ total ....80i—d.
sd
(*,.g.o at. t nt utotenwrt r. .d]
- May be 11111 if i...D (vMlsd 0 , 411i4
C .s eye (arid aiJ !ntobOn Do ‘ l get vi eyes.
evciqi me vi3 Do not s.me v o,s ( j.i or
on .za*. or cm d e Harnifti it esi oed CAp-
spray Irish Do nol get i .y . an V jn a’ on
davvng (Appropriate twit d slItnuI r, aSd I
prop t.frE.dshatImertreq.wad3
P4irmu ,j 1 swallowed (ithahed or sOlcibed OwOugli me
Avoid itacl rot W . eye. or doUwig In CaM of
sky) Avoid breseIng vapor. (eat or sony mist)
fltIc1 aTinebeteip Sjifi eyes a’ rot ple nty ad
Avoid contact isot skin (eyes a’ doewigl (Appr -
whir Gil msócal .ttsrlon if .ntIXn perwh*s
pliat. twit lid statement reqt sd I
(No precauXnwy ,tat.mrita rsquwedl -.
(No prucaubonwy s*at.m.nta reoiwhd 1
—91—
-------
§ 162.10
Title 40—Protection of Etwironniont
stances under which they are required
follow:
(A) If a pesticide intended for out-
door use contains an active ingredient
with a mammalian acute oral LD.. of
100 or less, the statement “This Pesti-
cide is Toxic to Wildlife” is required.
(B) If a pesticide intended for out.
door use contains an active ingredient
with a fish acute LC. of 1 ppm or’ less,
the statement “This Pesticide is Toxic
to Fish” is required.
(C) If a pesticide intended for out-
door use contains an active ingredient
with an avian acute oral LD. of 100
mg/kg or less, or a subacute dietary
LC 1 . of 500 ppm or less, the statement
“This Pesticide is Toxic to Wildlife” is
required.
(D) U either accident history or field
studies demonstrate that use of the
pesticide may result in fatality to
birds, fish or mammals, the statement
“This pesticide is extremely toxic to
wildlife (fish)” is required.
(E) For uses Involving foliar applica-
tion to agricultural crops, forests, or
shade trees, or for mosquito abate-
ment treatments, pesticides toxic to
pollinating insects must bear appropri-
ate label cautions,
(F) For all outdoor uses other than
aquatic applications the label must
bear the caution “Keep out of lakes,
ponds or streams. Do not contaminate
water by cleaning of equipment or dis-
posal of wastes,”
(ill) Physical or chemical hazards.
Warning statements on the flammabil-
ity or explosive characteristics of the
pesticide are required as follows’
- ., R. ed teit
(A) Pesssuqizw COeTAa nS
Fte t p n it ot 20 F, 8 n .e sa cii i
a, ene opsiwig.
Flsih opeti ovs 20’ F a ’ not 00’ F S t.
ni ..1. ,.ib S Itent then 18 m at a
S It from Vt. Sent.
Al oV p,ss .d — - -. - —
Esornu* tm’efrte Contents irdsc pmswe Kiep iwsy from
tes. sPats wi0 PISIISC S$tiCii Do not JttCttJU ot
n ri.r to Isn erst#.s move 130’ F nwy caas
tem
Ftenenabte Contents wee ’ otsiLRe Kiev swey front Mel
wets. w o t Santo Do nol tcos. ot iwit. mo,wi
EsP3VtV. to tVT 0 tie om 130’ F flt.7 c as teDIte
Content. wl .we Do not Ia. ot utes I tSut hsii
Sam. Do not tct,. wtott.Iste nta ’nr E ost,e to
opuiataes a s I 30 F nwy cuta. buasteig
(B) NOsePEssuRiuD COWTAIISRS
At ot bstow 20’ F — -‘ . .. .
Abom P0’ F end not SO’ F - - .. ..,.
P es SO’ F id not 180’ P — .. . ...
EzOsmuly Mevtt.Ote Kiep essy tmm i .e spats w nested
te . e
Ft.,, . ,,.Ll.. Kiep y front nest aid open Sam.
Do , ‘a. ot stove ,t. st ot opai Item.
(1) Directions for Use—( 1) General
requireinents—(1) Adeqwici, and cZar-
Uy qf directions. Directions for use
must be stated in terms which can be
easily read and understood by the av-
erage person likely to use or to super-
vise the use of the pesticide. When fol-
lowed. directions must be adequate to
protect the public from fraud and
from personal injury and to prevent
unreasonable adverse effects on the
environment,
(Ii) Placement of directions for use,
Directions may appear on any portion
of the label provided that they are
conspicuous enough to be easily read
by the user of the pesticide product.
Directions for use may appear on
printed or graphic matter which ac-
companies the pesticide provided that:
(A) If required by the Agency, such
printed or graphic matter is securely
attached to each package of the pesti-
cide, or placed within the outside
wrapper or bag:
(B) The label bears a reference to
the directions for use in accompanying
leaflets or circulars, such as “See di-
rections in the enclosed circular:” and
(C) The Administrator determines
that it is not necessary for such direc-
tions to appear on the label.
(iii) Exceptions to requirement for
direction for use—(A) Detailed direc-
tions for use may be omitted from la-
beling of pestIcides which are intended
—92--
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O apt.i I.
Prot•ctioii Ag.ncy
§ 162.10
for use only by manufacturers of prod-
ucts other than pesticide products in
their regular manufacturing processes.
provided that:
(1) The label clearly shows that the
product Is Intended for use only In
manufacturing processes and specifies
the type(s) of products involved.
(2) Adequate Information such as
technical data sheets or bulletins, Is
available to the trade specifying the
type of product involved and Its
proper use In manufacturing process-
es;
(3) The product will not come Into
the hands of the general public except
after incorporation into finished prod-
ucts: and
(4) The Administrator determines
that such directions are not necessary
to prevent unreasonable adverse ef-
fects on man or the environment.
(B) Detailed directions for use may
be omitted from the labeling of pest!-
cide products for which sale Is limited
to physicians. veterinarians, or drug-
gists, provided that:
(1) The label clearly states that the
product Is for use only by physicians
or veterinarians:
(2) The Administrator determines
that such directions are not necessary
to prevent unreasonable adverse ef-
fects on man or the environment: and
(3) The product Is also a drug and
regulated under the provisions of the
Federal Food. Drug and Cosmetic Act.
(C) Detailed directions f or use may
be omitted from the labeling of pesti-
cide products which are intended for
use only by formulators in preparing
pesticides for sale to the public, pro-
vided that:
(1) There is information readily
available to the formulators on the
composition, toxicity, methods of use.
applicable restrictions or limitations.
and effectiveness of the product for
pesticide purposes:
(2) The label clearly states that the
product Is intended for use only in
manufacturing, formulating, mixing.
or repacking for use as a pesttcide and
specifies the type(s) of pesticide prod-
ucts Involved:
(3) The product as finally tnaiiufac-
tured, formulated, mixed, or repack-
aged is registered: and
(4) The Administrator determines
that such directions are not necessary
to prevent unreasonable adverse ef-
I ect.s on man or the environment.
(2) Contents of Directions for Use
The directions for use shall include
the following, under the headings “Di-
rections for Use”:
(I) The statement of use classifica-
tion as prescribed In 162.10(3) ImmedI-
ately under the heading “Directions
for Use,”
(II) Immediately below the state-
ment of use classification, the state-
ment “It Is a violation of Federal law
to use this product in a manner incon-
sistent with its labeling.”
(ill) The site(s) of application, as for
example the crops, animAls, areas, or
objects to be treated.
(lv) The target pest(s) associated
with each site.
(v) The dosage rate associated with
each site and pest.
(vi) The method of application. In-
cluding Instructions for dilution, if re-
quired, and type(s) of application ap-
paratus or equipment required.
(vii) The frequency and timing of ap-
plications necessary to obtain effective
rerults without causing unreasonable
adverse effects on the environment.
(viii) Specific limitations on reentry
to areas where the pesticide has been
applied, meeting the requirements
concerning reentry provided by 40
CFR Part 170.
(lx) Specific directions concerning
the storage and disposal of the pesti-
cide and its container, meeting the re
qulrements of 40 CFR Part 165. These
Instructions shall be grouped and
appear under the heading “Storage
and DisposaL” This heading must be
set in type of the same minin um sizes
as required for the child hazard warn-
ing (See Table In 162J0(hXl)(Iv).)
(x) Any limitations or restrictions on
use required to prevent unreasonable
adverse effects, such as:
(A) Required Intervals between ap-
plication and harvest of food or feed
crops.
(B) Rotational crop restrictions.
(C) Warnings as required against use
on certain crops, animals, objects, or
In or adjacent to certain areas.
(D) (Reserved]
—93—
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§ 162.11
Title 4O—Pvot ctlo i of Eiiviromii.nt
(E) For restricted use pesticides, a
statement that the pesticide may be
applied under the direct supervision of
a certified applicator who is not phys•
ically present at the site of application
but nonetheless available to the
person applying the pesticide, unless
the Agency has determined that the
pesticide may only be applied under
the direct supervision of a certified ap-
plicator who is physically present.
(F) Other pertinent information
which the Administrator determines
to be necessary for the protection of
man and the environment.
(j) Statement of Use Ciasstficction.
By October 22, 1976, all pesticide prod-
ucts must bear on their labels a state-
ment of use classification as described
in paragraphs (j)(1) and (2) of this sec-
tion. Any pesticide product for which
some uses are 1a .cifled for general use
and others for restricted use shall be
separately labeled according to the la-
beling standards set forth In this sub-
section, and shall be marketed as sepa-
rate products with different registra-
tion numbers, one bearing directions
only for general use(s) and the other
bearing directions for restricted use(s)
except that. If a product has both re-
stricted use(s) and general use(s), both
of these uses may appear on a product
labeled for restricted use. Such prod.
ucts shall be subject to the provisions
of 162.1O(j)(2).
(1) General Use Claas(flcatlon. Pesti-
cide products bearing directions for
e( ) ‘1a ifj d general shall be la-
beled with the exact words “General
Classification” Immediately below the
heading “Directions for Use.” And ref-
erence to the general I ’iwlfiCatIon
that suggests or Implies that the gen•
eral utility of the pesticide extends
beyond those purposes and uses .
tamed In the Directions for Use will be
considered a false or misleading state-
ment under the statutory definitions
of misbranding.
(2) Restricted Use Class jflcation.
Pesticide products bearing direction
for use(s) eln sified restricted shall
bear statements of restricted use clas-
sification on the front panel as de-
scribed belov
(I) Front panel statement of restrict-
ed use c1a.ujficc lori. (A) At the top of
the front panel of the label, set In type
of the same minimum sizes as required
for human hazard signal words (see
table in 162.lO(h)(l)(lv)), and appear-
ing with sufficient prominence relative
to other text and graphic material on
the front panel to make It unlikely to
be overlooked under customary condi-
tions of purchase and use, the state-
ment “Restricted Use Pesticide” shall
appear.
(B) Directly below this statement on
the front panel, a summary statement
of the terms of restriction imposed as
a precondition to registration shall
appear. If use is restricted to certified
appUcators. the following statement is
required: “For retail sale to and use
only by Certified Applicators or per-
sons under their direct supervision and
only for those uses covered by the Cer-
tified Applicator’s certification.” If,
however, other regulatory restrictions
are Imposed, the Administrator will
define the appropriate wording for the
terms of restriction by regulation.
(k) Advertising. (Reserved)
(40 FR 28288, Jul 3, 1915, 40 FR 32329,
Aug. 1. 1975. 40 FR 36571. Aug 21. 1975. as
amended at 43 FR 5786, Feb. 9, 19783
—94—
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PHYSICAL/CHEMICAL HAZARDS
Criteria
Required Label Statement
I. Pre8surized Containers
A. Flashpoint at or below
20°F; or if there is a
flashback at any valve
opening.
B. Flashpoint above 20°F
and not over 80°F; or
if the flame extension
is more than 18 inches
long at a distance of
6 inches from the
valve opening.
C. All Other Pressurized
Containers
II. Non—Pressurized Containers
A. Flashpoint at or below
20°F.
B. Flashpoint above 20°F
and not over 80°F.
C. Flashpoint over 80°F
and not over 150°F.
D. Flashpoint above
150°F.
Extremely flammable.
Contents under pressure.
Keep away from fire, sparks,
and heated surfaces. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat, sparks, and flame. Do
not puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces.
Flammable. Keep away from
heat and open flame.
Do not use or store near
heat and open flame.
None required.
—95—
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STORAGE INSTRUCTIONS FOR PESTICIDES
Heading :
All products are required to bear specific label instructions
about storage and disposal. Storage and disposal instructions
must be grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL. Products
intended solely for domestic use need riot include the heading
STORACE AND DISPOSAL.”
Storage Instructions :
All product labels are required to have appropriate storage
instructions. Specific storage instructions are not prescribed.
Each registrant must develop his own storage instructions,
considering, when applicable, the following factors:
1. Conditions of storage that might alter the composition or
usefulness of the pesticide. Examples could be temperature
extremes, excessive moisture or humidity, heat, sunlight,
friction, or contaminating substances or media.
2. Physical requirements of storage which might adversely
affect the container of the product and its ability to
continue to function properly. Requirements might include
positioning of the container in storage, storage or damage
due to stacking, penetration of moisture, and ability to
withstand shock or friction.
3. Specifications for handling the pesticide container,
including movement of container within the storage area,
proper opening and closing procedures (particularly for
opened containers), and measures to minimize exposure
while opening or closing container.
4. Instructions on what to do if the container is damaged in
any way, or if the pesticide is leaking or has been
spilled, and precautions to minimize exposure if damage occurs.
5. General precautions concerning locked storage, storage in
original container only, and separation of pesticides
during storage to prevent cross—contamination of other
pesticides, fertilizer, food, and feed.
6. General storage instructions for household products should
emphasize storage in original container and placement in
locked storage areas.
-96—
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PESTICIDE DISPOSAL INSTRUCTIONS
The label of all products, except those intended solely for domestic
use, must bear explicit instructions about pesticide disposal. The
statements listed below contain the exact wording that must appear on
the label of these products:
1. The labels of all products, except domestic use, must contain the
statement, “Do not contaminate water, food, or feed by storage or disposal.”
2. Except those products intended solely for domestic use, the labels
of all products that contain active ingredients that are Acute Hazardous
Wastes (see list in this Appendix) or are assigned to Toxicity Category
I on the basis of oral or dermal toxicity, skin or eye irritation potential,
or Toxicity Category I or II on the basis of acute inhalation toxicity
must bear the following pesticide disposal statement:
“Pesticide wastes are acutely hazardous. Improper disposal of
excess pesticide, spray mixture, or rinsate is a violation of Federal
Law. If these wastes cannot be disposed of by use according to
label instructions, contact your State Pesticide or Environmental
Control. Agency, or the Hazardous Waste representative at the nearest
EPA Regional Office for guidance.”
3. The labels of all products, except those intended for domestic use,
containing active or inert ingredients that are Toxic Hazardous Wastes
(see list in this Appendix) or meet any of the criteria in 40 CFR 261.,
Subpart C for a hazardous waste must bear the following pesticide disposal
statement:
“Pesticide wastes are toxic. Improper disposal of excess pesticide,
spray mixture, or rinsate is a violation of Federal Law. If these
wastes cannot be disposed of by use according to label instructions,
contact your State Pesticide or Environmental Control Agency, or the
Hazardous Waste representative at the nearest EPA Regional Office
for guidance.”
4. Labels for all other products, except those intended for domestic
use, must bear the following pesticide disposal statement:
“Wastes resulting from the use of this product may be disposed of on
site or at an approved waste disposal facility.”
5. Products intended for domestic use only must bear the following
disposal statement: “Securely wrap original container in several layers
of newspaper and discard in trash.”
—97—
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CONTAINER DISPOSAL INSTRUCTIONS
The label of each product must bear container disposal
instructions appropriate to the type of container.
1. Domestic use products must bear one of the following
container disposal statements:
Container Type
S tatement
2. All other products must bear container disposal instructions,
based on container type, listed below:
Container Type
Statement
1/ Manufacturer may replace this phrase with one indicating
whether and how fiber drum may be reused.
Non—aerosolproducts
(bottles, cans, jars)
Do not reuse container (bottle, can, jar).
Rinse thoroughly before discarding in trash.
Non—aerosol products
(bags)
Do not reuse bag. Discard bag in trash.
Aerosol products
Replace cap and discard containers in
trash. Do_not_incinerate_or_puncture.
Metal
containers
(non—aerosol)
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or by
other procedures approved by state and local
authorities.
Plastic containers
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or
incineration, or, if allowed by state and
local authorities, by burning. If burned,
stay_out_of_smoke.
Glass containers
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved_state_and_local_procedures.
Fiber drums
with liners
Completely empty liner by shaking and
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
reused’,_dispose_of_in_the_same_manner.
Paper and
plastic bags
Completely empty bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning. If burned, stay
out__of__smoke.
Compressed gas
cylinders
Return empty cylinder for reuse (or
similar wording)
—98—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
TABLE OF CONTENTS
Site Name Page
TERRESTRIAL FOOD CROP 8
( Agricultural Crops ) 14
Asparagus 14
Broccoli 14
Cauliflower 14
Citrus Fruit (tree sites) 15
Deciduous Fruit Trees (including Apple, Apricot, Cherry and
Peach) 15
Eggplant 17
Grapes 17
Lettuce 17
Melons 18
Nut Crops, Nut Trees (including Almond and Walnut) 15
Onions (Direct Seeded) 18
Peppers 18
Pineapple 18
Strawberry 19
Tomato 19
TERRESTRIAL NON—FOOD CROP 19
( Agricultural Crops ) 19
Tobacco 19
( Ornamental Plants and Forest Trees ) 20
Forest Trees 20
Ornamental Lawns 20
Ornamental Plants (including nursery stock) 21
(Herbaceous Perennials) 22
(Ornamental Woody Shrubs) 22
Ornamental Turf 20
( General Soil Treatment and Composting ) 22
Bulk Soil (Potting Soil, Top Soil) 22
Compost Piles 22
Manure 22
Mulch (Hay, Manure, Straw) 23
Seed and Transplant Beds (nonfood) 23
( Noncrop, Wide Area, and General Indoor/Outdoor Treatments ) 24
Recreational Areas (including Athletic Fields, Golf Courses
and Parks) 24
GREENHOUSE FOOD CROP 24
( Agricultural Crops ) 25
Tomato 25
GREENHOUSE NON-FOOD CROP 25
( Agricultural Crops ) 25
( Ornamental Plants and Forest Trees ) 25
Nonfood/Nonfeed Crops (Greenhouses) 25
Issued: 3—07—84 111—053201—i
—99--
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EPA Compendium of Acceptab’e Uses
METHYL BROMIDE
TABLE OF CONTENTS
Site Name Page
DOMESTIC OUTDOOR 26
( Household ) 26
Domestic Dwellings (Outdoor) 26
( Wood or Wood Protection Treatment ) 26
Wooden Plant Stakes 26
INDOOR 26
( Agricultural Crops ) 37
Alfalfa (Hay) 37
Almond 37
Apple 38
Apricot 38
Artichoke (Jerusalem) 38
Barley 39
Beans 39
Beets (Roots) 40
Brazil Nut 37
Butternut 37
Cabbage 41
Cantaloupe 41
Carrots 42
Cashew 37
Cherry 42
Chestnut 37
Citron 43
Cocoa Beans 43
Corn 43
Corn, Pop 44
Corn, Sweet 44
Cotton (including Baled Cotton) 45
Cottonseed 46
Cucumber 46
Eggplant 47
Filbert (Hazelnut) 37
Garlic 47
Grapefruit 48
Grapes 48
Honeydew Melons 41
Horseradish (Roots) 49
Kumquat 48
Lemon 48
Lime 48
Macadamia Nut (Bushnut) 37
Mugkme lons 41
Nectarine 49
Oats 49
Okra 50
Onion 50
Onion (Cipollini Bulbs) 51
Issued: 3—07—84 111—053201—u
—100—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
TABLE OF CONTENTS
Site Name Page
Orange 48
Parsnip (Roots) 51
Peach 52
Peanuts 37
Pear 38
Peas 52
Pecan 37
Peppers 53
Pimento 53
Pineapple 53
Pistachio 37
Plum 53
Potato 54
Prune 54
Pumpkins 41
Quince 38
Radish 55
Rice 49
Rutabaga 55
Rye 49
Salsify (Roots) 55
Sorghum 55
Squash (Summer) 56
Squash (Winter) 56
Squash (Zucchini) 57
Sugar Beets 40
Sweet Potato 54
Tangelo 48
Tangerine 48
Tobacco 57
Tomato 47
Turnip (Roots) 51
Walnut 37
Watermelons 41
Wheat 49
Yams 59
( Processed or Manufactured Products, and Food or Feed
Containers or Dispensers 59
Airtight Chambers (Empty) (including Atmospheric Chambers,
Vacuum Chambers and Fumigation Vaults) 59
Burlap Bags (Empty) 59
Candy (Processed) 59
Cereals (Processed) 59
Cheese, Cheese Byproducts 60
Copra 60
Dog Feed 60
Eggs (Dried) 60
Feed/Food Containers (Empty) (including Bags, Boxes and
Crates) 60
Issued: 3—07—84 11 1—053201—ui
—101—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
TABLE OF CONTENTS
Site Name Page
Flour (including Bagged Cereal Flour, Bakery Mixes and
Cereal Flour) 61
Fruits (Dried) (including Apple, Apricot, Cherry, Date,
‘Fig, Peach, Pear, Prune and Raisin) 61
Grain Bins (Empty) 62
rain Products (Processed) 62
Herbs, Seasoning or Spices (Dried) 63
Meat P oducts (including Cured Meat Products) 63
Nonfeed/Nonfood Containers (Empty) (including Bags, Boxes
and Crates) 63
Paper (Stored) 63
Processed Foods 64
Tarpaulins 64
( Agricultural Premises and Equipment ) 65
Barns 65
Farm Storage Areas 66
Greenhouses (Empty) 66
Mushroom Houses (Empty) 66
Poultry Houses (Empty) 67
( Household ) 67
Domestic Dwelling Contents (including Furniture) 67
Domestic Dwellings (including Garages) 67
( Wood or Wood Structure Protection Treatment ) 69
Lumber and Wood Products 69
( Commercial and Industrial Uses ) 69
Boxcars/Railway Cars (Empty) 69
Food Processing, Handling and Storage Areas 70
Meat Processing Plants (including Ham Houses) 71
Ships (Cargo)/Steel Barges 71
Trailers (Empty) 72
Van Containers (Empty) 72
Issued: 3—07—84 III—053201—iv
—102—
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EPA Compendium of Acceptable Uses
cO532Ol METHYL BROMIDE*
TYPE PESTICIDE : Acaricide, Fungicide, Herbicide, Insecticide, Nematicide,
Rodenticide and Fumigant
FORMULATIONS :
Tech (100%)
Fl (67%)
PrGs (33%, 43%, 45%, 50%, 57%, 66%, 67%, 68.62, 702, 75%, 80%, 88.2%, 98%,
99%, 99.5%, 99.65%, 99.75%, 99.8%, 100%)
GENERAL WARNINGS AND LIMITATIONS : RESTRICTED USE PESTICIDE.
Extremely hazardous liquid and vapor under pressure. Inhalation may be
fatal or cause serious acute illness or delayed lung, nerve or brain in-
jury. Do not breathe vapor. Liquid or vapor can cause serious skin or
eye injury which may have a delayed onset. Do not get liquid on skin, in
eyes or on clothing. Wear full—body clothing that is cleaned after each
wearing, or disposable protective clothing. Do not wear gloves or boots
when handling. Methyl bromide is heavier than air and may be trapped in-
side and cause skin injury. If full—face respiratory protection is not
required, wear goggles or full face shield for eye protection when hand-
ling liquid. Do not reuse contaminated clothing or shoes until cleaned.
Use only with adequate ventilation when applied to structures and for
stored commodity fumigation. Keep children and animals away from areas
under treatment. Wear a self contained breathing apparatus (SCBA) or com-
bination air—supplied/SCM respirator jointly approved by the Mining
Enforcement and Safety Administration and by the National Institute for
Occupational Safety and Health under the provision of 30 Code of Federal
Regulations Part II. -
Fumigated areas must be placarded on all entrances with signs containing
at least the signal word DANGER and the “Skull and Crossbones” and the
words “Area under fumigation, do not enter until completely aerated”, the
date of fumigation, name of fumigant used, emergency telephone number for
contact, and the name and address of the fumigator. Do not remove warning
signs until the fumigated area is completely aerated and safe for entry,
as indicated by a suitable detector.
Before entering fumigated buildings and structures, determine the presence
or absence of harmful concentrations of methyl bromide gas. This can be
accomplished with the use of a halide gas detector or thermal conductivity
gas detector. Refer to approved labels and technical bulletins for use
directions of detectors.
A 5 parts per million (ppm) threshold limit value (TLV) for methyl bromide
has been established. Threshold limit value is defined as the concentra-
tion below which personal protective devices are not required for persons
entering or within a hazardous environment. Persons not wearing protec-
tive equipment should not enter the fumigated area until monitoring devic-
es show methyl bromide concentrations of 5 parts per million or less.
Methyl bromide may be formulated with chioropicrin.
*bromome thane
Issued: 3—07—84 1 1 1—053201—I
Provisional Update: 6—09—86 —103—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
GENERAL WARNINGS AND LIMITATIONS (continued)
Coimnoditieg Unsuited for Methyl Bromide Fumigations . The following is a
list of materials which should not be exposed to methyl bromide:
1. Foodstuffs
a. Iodized salt stabilized with sodium hyposulfite.
b. Full fat soya flour.
c. Certain baking sodas, cattle licks (i.e., salt blocks), or other
foodstuffs containing reactive sulfur compounds.
Note : Never exceed the recoimnended dosage or exposure period for food or
feedstuff commodities. Prior to repeated fumigation, have the food com-
modity analyzed for inorganic bromide residues.
2. Seeds, Bulbs, and Plants
a. Seeds and bulbs to be used for planting,*
b. Nursery stock and other living plants.*
3. Pets
(All pets, including fish and birds.)
4. Rubber Goods
a. Sponge rubber.
b. Foam rubber, as in pillows, cushions, mattresses, and some car
seats.
c . Rubber stamps and other similar forms of reclaimed rubber.
5. Furs
6. Horsehair
7. Feathers
(Especially in feather pillows.)
8. Leather goods
(Particularly white kid or other leather goods tanned with sulfur
processes).
9. Woolens
(Extreme caution should be used in the fumigation of Angora woolens.
Some adverse effects have been noted on woolen socks, sweaters,
shawls and yarn.)
10. Viscose Rayon
Those rayons processed or manufactured by a process in which carbon
bisulfide is used.
11. Vinyl
*For specific information on procedures to prevent commodity injury, con-
tact manufacturer or United States Department of Agriculture.
Issued: 3—07—84 111—053201—2
-104—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
GENERAL WARNINGS AND LIMITATIONS (continued)
Conunodities Unsuited for Methyl Bromide Fumigations (continued)
12. Paper
a. Silver polishing papers.
b. Certain writing and other papers cured by sulfide processes.
c. Photographic prints and blueprints stored in quantity.
d. Carbonless carbon paper.
e. Blueprint papers.
13. Cellophane*
14. Photographic Chemicals
(Darkroom chemicals, but not cameras or film.)
15. Rug Padding
(Foam rubber, felt, etc.)
16. Cinder Blocks
17. Mixed Concrete
(occasionally picks up odors)
18. Mixtures of mortar and/or soil used for chinking log cabins.
19. Charcoal
(Note: Methyl bromide is readily absorbed by charcoal. This may not
only contaminate such materials, but may reduce the concentration of
the gas in the fumigated area to the point of ineffectiveness.
**In the event of uncertainty about the possible presence of reactive sul-
fur compounds, conduct a trial fumigation of a small quantity of the
material in question.
PEST VOCABULARY AND LISTING
Methyl bromide labels frequently contain pest names which are broad and
nonspecific. Attempts have been made to identify the specific pests fal-
ling under such general names. These broad and general pest names appear
in this entry unless special use instructions or dosages are claimed for
specific pest.
Fungicide Claims
1. Soilborne fungi including:
a) Armillaria spp.
b) Crown rot fungi
c) Fusarium spp.
d) Plastuodiophora spp.
e) Phytophthora spp.
f) Pyrenochaeta spp.
g) Pythiuin spp.
Issued: 3—07—84 111—053201—3
—105—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
GENERAL WARNINGS AND LIMITATIONS (continued)
Fungicide Claims (continued)
h) Rhizoctonia spp.
i) Sclerotinia spp.
j) Sclerotium spp.
k) Verticillium spp.
Herbicide Claims
2. Weeds (including seeds, roots, stolons and bulbs of broadleaf
weeds and grasses) including:
a) Annual bluegrass
b) Barnyardgrass
c) Bermudagrass
d) Broomrape
e) Chickweed
f) Cotmnon lambsquarters
g) Crabgrass
h) Crowfootgrass
i) Goosegrass
j) Mornirigglory
k) Nutsedge
1) Oxalis
m) Pigweed
ii) Purslane
o) Torpedograss
Note: Methyl bromide is ineffective against some species of clover,
dodder, filaree, mallow and other hard—seeded weeds.
Insecticide Claims
3. Soilborne insects including:
a) Garden symphylan
b) June beetles (larvae)
c) White grubs
d) Wireworms
4. Stored product insects including:
a) Angoumois grain moth
b) Australian spider beetle
c) Bamboo powderpost beetle
d) Bean weevil
e) Black carpet beetle
f) Cadelle
g) Carpet beetle
h) Cigarette beetle
i) Cockroaches
j) Coffee bean weevil
k) Confused flour beetle
I) Covpea weevil
m) Derniestid beetle
n) Driedfruit beetle
Issued: 3—07—84 111—053201—4
—106—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
GENERAL WARNINGS AND LIMITATIONS (continued)
Insecticide Claims (continued)
o) Drugstore beetle
p) Flat grain beetle
q) Fungus beetle
r) Furniture beetle
s) Grain borers
t) Grain mite
u) Granary weevil
v) Hairy fungus beetle
w) Indianmeal moth
x) Khapra beetle
y) Larder beetle
z) Leafminers
aa) Lesser grain borer
bb) Mealworms
cc) Mediterranean flour moth
dd) Merchant grain beetle
ee) Odd beetle
ff) Otiorhyncus weevils
gg) Pea weevil
hh) Raisin moth
ii) Red flour beetle
jj) Redlegged ham beetle
kk) Rice weevil
11) Rusty grain beetle
mm) Sawtoothed grain beetle
nn) Seed weevils
oo) Sweetpotato weevil
pp) Tapestry/carpet moth
qq) Trogoderma beetle
rr) Varied carpet beetle
ss) Warehouse beetle
tt) Whitefringed beetles
Note: The dosage rates used to control the life stages of Khapra
beetle are covered by the recommendations and instructions issued by
the United States Department of Agriculture food quarantine programs,
to Se used only by or under the direction of federal/state quarantine
treatments.
5. Wood destroying insects including:
a) Ambrosia beetles
b) Anobiid powderpost beetles
c) Bark beetles
d) Bostrichid beetles
e) Carpenter ants
f) Carpenter bee
g) Drywood termites
h) Flatheaded wood borers
i) Lyctid beetles
Issued: 3—07—84 111—053201—5
—107—
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EPA Compendium of Acceptable Uses
GENERAL WARNINGS AND LIMITATIONS (continued)
Insecticide Claims (continued)
j) Old house borer
k) Roundheaded wood borers
1) White pine weevil
Nematicide Claims
6. Nematodes including:
a) Burrowing nematode
b) Citrus nematode
c) Dagger nematodes
d) Lance nematodes
e) Lesion nematodes
f) Pin nematodes
g) Root—knot nematodes
h) Spiral nematodes
i) Sting nematodes
j) Stunt nematodes
k) Criconemoides spp.
CFR 180,199 —
CFR 193.225 —
CFR 193.230 —
CFR 193 .250
Agricultural Crop
The tolerances of
dues of inorganic
gated with methyl
Issued: 3—07—84
111—053201—6
-108—
METHYL BROMIDE
CFR 180.123
Tolerances :
The following sections of Code of Federal Regulations (CFR) list
tolerances for residues for methyl bromide:
— Inorganic bromides resulting from fumigation with
methyl bromide.
Inorganic bromides resulting from soil treatment with
combinations of chioropicrin, methyl bromide and pro—
pargyl bromide.
Fumigants, including carbon disulfide, carbon tetra—
chloride, ethylene dibromide, ethylene dichioride,
and/or methyl bromide.
Fumigants, incLuding carbon tetrachloride, carbon
disulfide, ethylene dichioride, pentane, and/or methyl
bromide.
and 561.260 — Inorganic bromide in certain processed
foods.
Tolerances (other than those listed in the text):
raw agricultural conmiodities are established for resi—
bromides (calculated as bromine) which have been fumi—
bromide after harvest:
Avocados
—
75
ppm
Blueberries
—
20
ppm
Coffee Beans
—
75
ppm
Cumin, Seed
—
100
ppm
Ginger, Roots
—
100
ppm
Mangoes
—
20
ppm
Papayas
—
20
ppm
Potnegranates
—
100
ppm
Soybeans
—
200
ppm
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
GENERAL WARNINGS AND LIMITATIONS (continued)
Agricultural Crop Tolerances (continued)
Timothy, Hay — 50 ppm
Processed Food/Peed Commodity Tolerances (other than those listed in the
text):
The tolerances of processed food/feed commodities are expressed as
inorganic bromides.
Citrus Pulp, Dehydrated — 90 ppm
Malt Beverages — 25 ppm
Tomato Products, Concentrated — 250 ppm
Issued: 3—07—84 111—053201—7
—109—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation( s)
TERRESTRIAL FOOD CROP
General Warnings and Limitations : When fumigating soil, observe these
precautions:
Drivers of application equipment must advise other workers of all precau-
tions and procedures. In addition, drivers must instruct their helpers
in the mechanical operation of the tractor and how to safely work with the
tractor and driver while fumigating.
Handle this fumigant in the open, with the operator upwind from the con-
tainer where there is good ventilation.
Always have adequate clean water available to wash skin and/or flush eyes.
When fumigating soil from a tractor, 5 gallons of water must be carried
on the tractor and placed where it is readily accessible. In addition to
water available on the tractor, at least 5 gallons of additional water
must be available from the service truck. The water must be drinkable but
in containers marked “WATER NOT FOR DRINKING”.
Check fumigant pressure system for leaks before beginning operation.
Do not lift injection shanks to turn at end of a pass until fumigant has
drained from system following closure of shutoff valve.
Trash pulled by the shanks to the end of the field when fumigating must
be covered by lifting the shanks, then covering the trash with polyethyl-
ene film before making the turn for the next pass.
In case of a rupture of hose or fitting while applying fumigant, immedi-
ately stop tractor and motor. Get off tractor and get to a place where
the problem can be observed without exposure to fumes. Approach from up-
wind with respiratory protection if required, and make necessary repairs.
When changing the cylinders be certain they are turned off and fumigant
system is not under pressure. Do not open the system when there are
people or structures downwind.
Post all treated areas with warning signs.
Keep all animals, children and unauthorized people away from area under
fumigation during the exposure period and during removal of tarpaulin,
Fumigation with methyl bromide and/or chloropicrin sometimes slows down
the rate of nitrification (the conversion to nitrates from ammonia by bac-
terial action). Certain ammonia—sensitive plants such as tomatoes may
suffer growth inhibition or stand reduction when planted in fumigated
soils containing high amounts of aumionia nitrogen. Accumulation of ammo—
nium is most likely to occur when maximum rates of fumigant and fertilizer
are applied to soils that are acidic, wet, cold or high in organic matter.
Issued: 3—07—84 111—053201—8
—110—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation( s)
General Warnings and Limitations (continued)
To lessen this hazard, at least one—half and preferably all of the nitro-
gen fertilizer added issnediately before or soon after fumigation should
be in the form of nitrate nitrogen. This hazard may also be reduced by
delaying planting until several months after fumigation if a nitrate form
of nitrogen such as sodium or calcium nitrate is not readily available.
Ammonium nitrate used sparingly will supply the nitrogen needed without
risk. Phosphorous, potassium and other plant nutrients should be used
according to soil needs.
Application should be made several months prior to planting to soils high
in organic matter such as muck, compost, and heavily manured soils since
they seem more likely to undergo some changes (possible effect on micro-
organisms) resulting in poor growth.
Do not treat very cold (below 50 F or 10.0 C), very wet, or dry soils.
Be sure treated plots are free from gas before planting seed or setting
out plants. If there is doubt as to complete aeration, working the soil
after treatment will aid, particularly when the soil is cool and/or wet.
Do not contaminate fumigated areas by walking from unfumigated soil.
Clean your shoes thoroughly if this is necessary. If the treated bed is
in a location where flooding or washing is possible after rains, plow a
furrow or make a trench around the treated area for proper drainage.
Wooden frames around the beds are also satisfactory for preventing this
type of contamination.
Do not allow domestic animals to feed on crop residues unless a tolerance
exists for such use.
Do not feed hay or straw treated directly or harvested from treated soils
to any animal.
Undesirable concentrations of chloropicrin following soil fumigation with
this material may drift to nearby areas. If this occurs, inunediately
cover treated area with a plastic tarpaulin. The tarpaulins should remain
in place overnight and be removed during the daytime if the escaping
vapors reach an undesirable concentration, as indicated by eye irritation,
the treated areas should be recovered. Since air movement assists the
dilution of the escaping fumes it is most likely that undesirable concen-
trations will build up during evening or nights when the air is static.
Application of this material should not be made when there is little or
no air movement or when there is an inversion.
Pretreatment Soil Preparation
Plow or rip the soil to the depth to which effective treatment is requir-
ed. The soil should be worked until free of clods or large lumps. Resi-
due from previous crops should be worked into the soil to allow for decom—
Issued: 3—07—84 111—053201—9
—111—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation( a)
General Warnings and Limitations (continued)
position prior to fumigation. Soil moisture 8hould be optimum for seed
germination. Coarse textured soils can be fumigated with higher moisture
content than fine textured soils. For best results, soil should be kept
moist for at least 4 days prior to treatment. Do not fumigate if the soil
temperature is below 50 F (10.0 C). For best results, fumigate when soil
temperature is 60 to 80 F (15.6 to 26.7 C) at the depth of 6 to 8 inches.
Soil Fumigation Methods
Use one of the following preplant methods:
1. Augering method (suitable for use in non—compacted or lightly strati-
fied soils): Dig hole 3 to 5 feet deep with auger and, if necessary
back—fill hole to provide final depth of 3 feet. Insert applicator
tube or probe, fill hole and release entire dosage for 100 square foot
site. When fumigant has been completely released, remove applicator
and tamp or compact hole with soil or cover site with polyethylene
tarp for 7 days.
2. Back—Hoe method (especially suitable in highly compacted, hard pan
soils): In stratified soils dig a trench 5 feet deep, 6 feet long and
as wide as the hoe; in deeply compacted soil, prepare a site the size
of the area in which the tree is to be grown. Back—fill with 2 feet
of soil, place applicator outlet at the 3—foot level and complete
back—fill. Release entire dose for 100 square feet, remove applicator
and tamp soil lightly over opening to seed fumigant in the site.
3. Chisel method (suitable for light, non—compacted soils): Rip dry soil
to a depth of 18 to 24 inches, disk to smoothness, inject fumigant by
chisel application to a depth of 36 inches and cover with polyethylene
film for 7 days. For overall field fumigation , using a chisel type
applicator, inject the product with the chisels spaced no more than
12 inches apart. Inject the fumigant to a depth of 6 to 8 inches be-
low the soil surface. The soil surface must be covered immediately
after treatment with simultaneous film laying equipment or by sealing
with a roller or a cultipacker and covered within 20 minutes with
polyethylene film or other suitable cover.
4. Hot gas method : The method consists of using a commercially manufac-
tured heat exchanger or a copper coil inmiersed in a vessel containing
hot water, to vaporize the fumigant before introduction. This method
is useful where large amounts of fumigant are required and rapid
vaporization is advantageous.
5. Raised tarp fumigation method : Support the center of the cover to
provide a small gas dome. Inflated plastic bags, crumpled fertilizer
bags, burlap bags stuffed lightly with hay or straw, inverted baskets,
flowerpots or bottles placed in the soil may be used for support.
Issued: 3—07—84 111—053201—10
—112—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Forinulation( s)
General Warnings and Limitations (continued)
Evaporating pans are essential for the volatilization and uniform dis-
persion of fumigant. Shallow pans or basins made of plastic or tinned
sheet metal are satisfactory for this purpose.
a) Use I evaporator pan for each 300 to 400 square feet of area.
b) Anchor one end of each polyethylene tube into an evaporating pan
with tape or a suitable weight. This insures that the liquid will
be directed into the evaporating pan.
c) Extend the free ends of the polyethylene tubes outside of the area
to be covered.
d) After the supports and tubing are in place, cover the area to be
fumigated with a gasproof cover of polyethylene or coated fabric
film.
e) Position the cover with its edges in a prepared furrow or trench.
f) Seal 6 to 10 inches of the outside edges with dirt. Tamp the
dirt down so edges will not pull loose.
g) Attach a polyethylene tube to the cylinder value outlet and open.
Use a cylinder dispenser or scale to meter small amounts.
6. Tree site injector method (suitable for light, non—compacted soils):
Insert injector into soil to a depth of 18 inches or more, tamp soil
lightly around injector, release entire dose for 100 square feet site,
move away from injector until all fumigant has been released, then re-
move injector and seal hole with taxnped soil.
Equipment Calibration : Calibrate fumigation equipment accurately before
application. Refer to labels to determine proper orifice size and pres-
sure required to deliver the desired dosage.
Exposure and Aeration Periods : In general, expose for 24 hours when tem-
perature is above 60 F (15.6 C) and for 48 hours when temperature is be-
tween 50 to 60 F (10.0 to 15.6 C). After the exposure, aerate soil for 3
days before seeding or 5 to 14 days before setting out vegetative growth.
If odor of fumigants persist at the end of aeration period, disc or plow
the soil to assist aeration.
Issued: 3—07—84 111—053201—1 .1
—113—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations (continued)
Special Instructions for the Control of Armillaria Root Rot (Armillaria
melea) on Deciduous Fruits and Nuts, Citrus and Vineyards
Pretreatment Soil Preparation : To obtain the maximum control of Armilla—
na mellea, soil must be dry to a depth requiring treatment. This can be
accomplished by: a) planting sudangrass in the spring, irrigating until
the grass has established itself, then withholding further irrigation; b)
by naturally allowing plants to grow without irrigation. When soil is
dry, cut and remove grass, plants and debris. Rip soil to a depth of 36
inches and disc to smoothness.
Methods of Application : This is a preplant or replant treatment. Do not
apply to soil where trees or vines will bear harvestable fruit within 24
months. Methods of application are as follows.
1. Non—tarp Chisel Application (Not for Use in CA). After the soil has
been properly prepared, inject dosage by chisel application with
chisels spaced 48 to 66 inches apart to a depth of 24 to 30 inches.
In the row strip, treatments may be made by using a single shank.
Chisels should have a wing welded on the back 2 to 4 inches above the
chemical outlet to partially break the chisel mark. To fill in the
chisel mark and seal the surface, disc and ringroll immediately after
fumigant injection. Be sure that the disc and ringroller cover an
area sufficiently beyond the chisel lines to effect a good seal.
2. Tarp Chisel Application . After the soil has been properly prepared,
apply dosage by chisels spaced 48 to 66 inches apart and cover with
adequate polyethylene film seal.
3. Deep Injection Auger—Probe Treatment . Use 1 pound active per injec-
tion site in light soils (2 pounds in fine—textured soils) to a depth
of 36 inches or more below the soil surface. Use 1 injection site per
100 square feet (on a 10 feet by 10 feet grid pattern) with the injec-
tion in the center of the area to be treated.
Exposure and Aeration Period : To insure the proper time—concentration re-
lationship to control Armillaria root rot, expose for 7 days before remov-
ing the polyethylene film cover for chisel applications, and expose for a
1 day interval with deep injection auger—probe treatment. Planting or re—
planting of trees, vines or other deep—rooted crops may begin 14 days af-
ter the period of exposure.
Issued: 3—07—84 111—053201—12
—114—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations (continued)
Special Instructions for Non—Tarp Nematode Control on Deciduous Fruits and
Nuts, Citrus and Vineyards
Pretreatment Soil Preparation : Plow or rip the soil to the depth to which
effective treatment is required. The soil should be worked until free of
clods or large lumps and residue from previous crops should be worked into
the soil to allow for decomposition prior to fumigation. To insure maxi-
mum fumigant penetration, the soil at the point of injection should not
contain more than 5 to 15 percent moisture depending on soil type. How-
ever, to improve sealing, the soil surface may be moistened by means of a
sprinkler application of 0.25 to 0.5 inch of water prior to final penetra-
tion and application. Avoid treatment of soils that contain more than 30
percent clay or those with high organic content. For best results, fumi-
gate when the soil temperature is 60 to 80 F (15.6 to 26.7 C) at the
depth of 6 inches. Do not fumigate when soil temperature is below 50 F
(10.0 C).
Methods of Application : This is a preplant or replant treatment. Do not
apply to soil where trees or vines will bear harvestable fruit within 24
months. A waiting period of at least 14 days should be observed between
application and planting. Methods of application are as follows:
I. Chisel Application . After the soil has been properly prepared, inject
fumigant with chisels spaced up to 66 inches apart to a depth of 24 to
30 inches. In the row strip, treatments may be made by using a single
shank. Chisels should have a wing welded on the back 2 to 4 inches
above the chemical outlet to partially break the chisel mark. To fill
in the chisel mark and seal the surface, disc and ringroll immediately
after fumigant injection. Be sure that the disc and ringroller cover
an area sufficiently beyond the chisel lines to effect a good seal.
2. Deep Injection Auger—Probe Treatment . Use 1 pound active per injec-
tion site in lighter soils; 2 pounds in fine textured soils. Use 1
injection site per 100 square feet (on a 10 feet by 10 feet grid pat-
tern) with the injection in the center of the area to be treated.
Tamp or compact the soil at the point of injection.
Issued: 3—07—84 111—053201—13
—115—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Fozmulation( 8)
( Agricultural Crops )
116002AA Asparagus 300 ppm (in combination with chloro ’
picrin)
Use limited to CA.
One year preharvest interval through
400 pounds per acre.
NABAAAA Nematodes 300—400 lb/A Preplant soil fumigation.
P ADQBB Soilborne fungi (67%, 75%,
PMAAAA Weeds 80%, 99.5%
PrGs)
/13005AA Broccoli 25 ppm (in combination with chloro
/13008AA ( auliflower picrin)
/O IO I6AA Preplant soil fumigation through 800
/060 13AA pounds per acre.
/10001AA
/ I 1001AA
/1 1 005AA
/28017AA
FKAAQBB Daiaping—off (in- 800 lb/A Preplant soil fumigation of trans—
cluding Fusarium, or plant bed.
Pythium and Rhi— 2 lb/l00
octonia) sq.ft
(98% PrGs)
ABAAAA Nematodes 148—240 lb/A Preplant soil fumigation.
FKADQBB Soilborne fungi (33%, 45%,
tNAAAJA Soilborne insects 50%, 57%,
PAAAAAA Weeds 66%, 67%,
68,6%, 70%,
75%, 80%,
88.2%,
98%, 99%,
99.5%,
99.65%,
99.75%,
100% PrCs)
151—686 lb/A Preplant soil fumigation of trans—
or plant bed.
1 lb/lOO
sq.ft
(68.6%,
88.2%, 98%,
99,5% PrGs)
Issued: 3—07—84 111—053201—14
—116—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest
Formulation(s)
Cauliflower
Citrus Fruit (tree sites)
Deciduous Fruit Trees (includir g
Apple, Apricot, Cherry and Peach)
Nut Crops, Nut Trees (including
Almond and Walnut )
F ICBABX Armillaria root rot 400—870 lb/A
(Armillaria tnelea) (982, 99.52
PrGs)
1—2 lb/injec-
tion site
(1 injection
site/tOO
sq. ft
(982 PrGs)
Tolerance, Use, Limitations
See Broccoli cluster.
N.F 0
Preplant soil fumigation through 870
pounds per acre.
In colder climates, treat in fall
and plant following spring. In
warmer climates, do not plant until
30 days after application.
Do not apply to soil where trees or
vines will bear harvestable fruit
within 24 months. A waiting period
of at least 14 days should be ob-
served between application and
planting.
Dosages for the control of nematodes
and Armillaria root rot will not
usually control weed seeds under
very dry conditions. However, some
control may be observed on deep—
rooted perennials.
Not for use in CA.
Preplant or replant soil fumigation.
Apply by non—tarp chisel application
method.
or replant soil fumigation.
tarp chisel application
Preplant or replant soil fumigation.
Apply by deep injection auger—probe
treatment. Use the lower dose for
lighter soil and the higher dose for
fine textured soils.
MABAAAA
Nematodes
400—870 lb/A
(98%, 992,
99. 5%,
99.65%,
99.75%, 1002
PrGs)
Preplant or replant soil fumigation.
Apply by chisel application method.
111—053201—15
—117—
/O2000AA
/ 2 8038AA
/ O3000AA
/ 0101 4AA
Preplant
Apply by
method.
Issued: 3—07—84
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Citrus Fruit (tree sites) cluster (continued)
435870 lb/A Preplant soil fumigation. Apply by
(98%, 99%, topical application method.
9905%,
99.65%,
99.75%, 100%
PrGs)
1—2 lb/injec— Preplant soil fumigation. Apply by
tion site deep injection auger—probe treat
El injection nt. Use the lover dose for light—
site/lOO er soil and the higher dose for fine
sq,ft textured soils.
(98% PrGs)
NABAA.AA Nematodes 150—650 lb/A Preplant soil fumigation to field,
FKADQBB Soilborne fungi (43%, 50%, nursery stocks and transplant beds.
ENAAAJA Soilborne insects 67%, 68.6%,
PAAAAAA Weeds 75%, 98%,
99.5%, 100%
PrGs)
or
1—1.5 lb/tOO
sq .ft
(75%, 98%,
99.5%, 100%
PrGs)
IO2000AA (Citrus Fruit (tree sites))
NEMBABA Citrus nematode 0033—1.5 Use limited to FL sandy soils.
F AGPCN Phytophehora spp. lb/tOO sq.ft Preplant or replant soil fumigation.
(33%, 45%,
50%, 57%
67%, 68.6%,
70%, 75%,
80%, 88.2%,
98%, 99.5%,
100% PrGs)
Issued: 3—07—84 III—O532O1 16
—118—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Tolerance, Use, Limitations
Formulation(s )
/UOO IAA Eggplant 20 ppm
60 ppm (in combination with chloro—
picrin)
Preplant soil fumigation through 800
pounds per acre.
Refer to Broccoli cluster.
/OIOI4AA Grapes N.F.
Preplant soil fumigation through 600
pounds per acre.
FKAGABX Armillaria Spp. 400-600 lb/A Preplant soil fumigation. Apply the
(98%, 99.5%, lover dose for light sandy soil and
100% PrGs) the higher dose for fine textured
soils.
FKACPCN Phytophthora spp. 600 lb/A Preplant soil fumigation. Treat in
(98%, 99.5%, suer or fall and plant following
100% PrCs) spring. Claim for control is limit-
ed to sandy and fine textured clay
soils.
Refer to Citrus Fruit (tree sites) cluster for ad-
ditional information.
/ 13020AA Lettuce 300 ppm (in combination with chloro—
picrin)
Preplant soil fumigation through
400 pounds per acre.
Do not make more than 1 application
in 2 to 3 years.
Use limited to CA.
FVLBWA Lettuce big vein 200—300 lb/A Preplant soil fumigation.
(67%, 75%,
80%, 99.5%,
PrGs)
NABAAAA Nematodes 300—400 lb/A
PAAAAAA Weeds (67%, 75%,
80%, 99.5%
PrOs)
Issued: 3—07—84 111—053201—17
—119—
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Forinulation( s )
/ 1 000 IAA Melons 40 ppm (for muskmelon; in combina-
tion with chioropicrin)
Preplant soil fumigation through 800
pounds per acre.
Refer to Broccoli cluster.
Nut Crops, Nut Trees (including
Almond and Walnut ) See Citrus Fruit (tree sites) clus-
ter.
/l4OllAA Onions (Direct Seeded ) 300 ppm (in combination with chioro—
pi c rin)
Do not make more than one app tica—
tion per year.
Preplant soil application through
300 pounds per acre.
NABAAAA Nematodes 300 lb/A Use limited to areas west of Rocky
PAAA.AAA Weeds (67%, 75%, Mountains.
PICRQBB White rot 80% PrGs) Preplant soil fumigation. In north-
ern states, late suner or early
fall treatments are best for soil
to be planted for early spring
crops.
/28017AA Peppers 25 ppm (in combination with chloro—
picrin)
Preplant soil fumigation through 800
pounds per acre.
Refer to Broccoli cluster.
/060 13AA Pineapple 25 ppm (in combination with chioro—
picrin)
Preplant soil fumigation through 800
pounds per acre.
Refer to Broccoli cluster.
Issued: 3—07—84 1 11—053201—18
—120—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
/0101 6AA
Site and Pest
Strawberry
Dosages and
Formulation(s )
Tolerance, Use, Limitations
25 ppm (in combination with chioro—
picrin)
Preplant soil fumigation through 800
pounds per acre.
40 ppm (in combination with chioro—
picrin)
Preplant soil fumigation through 800
pounds per acre.
General Warnings and Limitations : See TERRESTRIAL FOOD CRQP General
Warnings and Limitations.
( Agricultural Crops )
/ 26003AA
FIAHPCN
FGATP DZ
FGATVAK
Tobacco
B lack shank
Granville wilt
Verticillium wilt
19—28.5 lb/A
[ 0.27—0.4
lb/lOO ft
row)
(67% PrGs)
FKAAQ BB
Damping—off (in-
cluding Fusarium,
Pythium and Rhi—
zoctonia)
800 lb/A
or
2 lb/lOO
sq.ft
(98%, 99.5%,
100% PrGs)
Preplant soil fumigation of trans-
plant bed.
NABAAAA
F ADQBB
IMAAAJA
PAAAAAA
Neinatodes
Soilborne fungi
Soilborne insects
Weeds
165—872 lb/A
(66%, 67%,
68.6%,
88.2%, 98%,
99%, 99.5%,
99.65%,
99.75%,
99.8%, 100%
PrGs)
111—053201—19
—121—
/1 1005AA
Refer to Broccoli cluster.
Tomato
TERRESTRIAL NON-FOOD CROP
Refer to Broccoli cluster.
Preplant soil fumigation.
Preplant soil fumigation of field
and transplant bed.
Issued: 3—07—84
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest
Do _ g g artd
Formulation( 3 )
Tolerance, Use, Limitations
/ 30000AA
( Ornamental Plants and Forest Trees)
General Warnings and Limitations : For reasons not clearly understood,
plant growth has occasionally been iinsatisfactory following soil fumiga
tion with methyl bromide on the following ornamental plants: conifers,
salvia, snapdragon, carnation, multf.flora roses, holly and certain other
plants. Every grower should use methyl bromide on a small scale under
his growing conditions for at least a full growing season before exten-
sive use.
Forest Trees
FKAAQBB
Damping—off (in-
cluding Fusarium,
Pythium and Rhi—
zoctonia)
800 lb/A
or
2 lb/laO
sq.ft
(98%, 99.5%,
100% PrGs)
Preplant soil fumigation of trans
plant bed.
Ornamental Lavns
Ornamental Turf
150—500 lb/A
(43%, 50%,
57%, 66%,
67%, 68.6%,
88.2%, 98%,
99%, 99.5%,
99.65%,
99.75%,
99.8%, 100%
PrCs)
Prep].ant soil fumigation. Seeds of
certain weeds such as clover, morn-
ing glory, filaree and others with
hard seeds may require a higher dos-
age or a longer exposure period for
effective control.
Treatments and dosages described be-
low can be used for turf renovation.
Work up the turf before fumigating 0
Undisturbed turf may be killed by
fumigation and the dead sod sprigged
or seeded after removal of the cov-
er. Frequent sprinkling after seed-
ing will insure a uniform stand.
FKAA BB
Damping—off (in-
cluding Fusarium,
Pythium and Rhi—
zoctonia)
800 lb/A
or
2 lb/100
sq .ft
(98%, 99.5%,
100% PrGs)
Preplant soil fumigation.
Issued: 3—07—84
111—053201—20
—122—
Nemat odes
Soilborne fungi
Soilborne insects
Weeds
4ABAAAA
FKADQBB
IMAAAJA
PAAAAAA
/33 00IAA
/ 3 3008AA
/ 6700 20A
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest
Dosages and
Portnulation( 3 )
Tolerance, Use, Limitations
Ornamental Lawns cluster (continued)
NAZA.AAA
- PKADQBB
IMAAA.JA
PAAAAAA
Nematodes
Soilborne fungi
Soilborne insects
Weeds
165—500 lb/A
(43%, 57%,
66%, 67%,
68.6%, 702,
-75%, 88.2%,
98%, 99%,
99.5%,
99.65%,
99.75%,
99.82, 100%
PrGs)
or
I. lb/l0O
sq.ft
(98%, 99.5%,
100% PrGs)
/ 32000A.A
/32000DA
/ 3 1000AA
/34004AA
FKAAQBB
Damping—off (in-
cluding Fusarium,
Pythium and Rhi—
zoctonia)
800 lb/A
or
2 lb/lOU
sq.ft
(98%, 99.5%,
100% PrGs)
150—500 lb/A
(332, 43%,
45%, 50%,
57%, 66%,
67%, 68.6%,
70%, 75%,
802, 88.2%,
98%, 99%,
99.52,
99.65%,
99.75%, 100%
PrGs)
or
1 Lb/lOO
sq. ft
(98%, 99.5%,
100% PrGs)
Preplant soil fumigation. Seeds of
certain weeds such as clover, morn-
ing glory, filaree and others with
hard seeds may require a higher dos-
age or a longer exposure period for
effective control.
UI—OS 3201—21
—123—
Ornamental Plants (including
nursery stock )
Preplant soil fumigation of trans-
plant bed.
NABAAAA
FKADQBB
IMAAAJA
PP .AAAAA
Nema t odes
Soilborne fungi
Soilborne insects
Weeds
Issued: 3—07—84
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest
Dosages and
Formulation( 3 )
Tolerance, Use, Limitations
Ornamental Plants (including nursery stock ) (continued)
(Herbaceous Perennials)
(Ornamental Woody Shrubs)
Nematodes 300—600 lb/A
Soilborne fungi or
Soilborne insects 0.75—1 lb/lOO
Weeds sq.ft
(tree sitel
(68.6%, 75%,
98%, 99.5%,
100% PrGs)
( General Soil Treatment and Composting )
Preplant soil fumigation. In colder
climates, treat in fall and plant
following spring. In warmer cli-
mates, do not plant until 30 days
after application.
General Warnings and Limitations : Fumigation should take place outdoors
or in a well ventilated area away from desired plants or occupied build-
ings. The material to be treated should have a temperature of 60 F
(15.6 C) or above, be loose, and moist enough for good seed germination.
To insure a good seal, pile the material to a depth of 19 inches on a
concrete floor or on wet ground. Piles 2 to 3 feet high can also be
treated provided perforations are made in the pile surface at one foot
intervals to assist penetration. Once the pile has been made, install
supports to hold the cover a few inches above the pile surface to aid
in proper fumigant diffusion. Place the outlet of the applicator tube
or tubes in evaporating pans spaced about 30 feet apart on the pile sur-
face. Cover with a polyethylene sheeting or other gas confining tnateri—
a]. of 4 mil or greater thickness. Seal the edges by burying, covering
with moist sand or soil or by means of sand snakes. Introduce the fumi-
gant into the evaporating pans as a liquid or by means of the hot gas
method. Aerate for 24 to 72 hours before planting.
FKAAQ B B
Damping—off (in-
cluding Pusarium,
Pythium and Rhi-
zoctonia)
1 lb/cu.yd
(98%, 99%,
99.75%, 100%
Pr Ga)
0.5—1 th/
cu.yd
(98%, 99%,
99.75%, 100%
PrGs)
General soil fumigation. Preplant
treatment of compost, manure, pot-
ting soil and top soil for use in
transplant beds.
General soil fumigation. Preplant
treatment of compost, manure, pot-
ting soil and top soil for use in
transplant beds.
Issued: 3—07—84
111—053201—22
—124—
/3I000AA
/34004AA
NABAAAA
FKADQBB
IMA.AAJA
PAAAAAA
/ 400 000A
/ 40 0 03 CA
/400 01KA
Bulk Soil (Potting Soil, Top Soil)
Compost Piles
Manure
NABAAAA
FKADQ BB
IMAAAJA
PAAAAAA
Nema todes
Soilborne fungi
Soilborne insects
Weeds
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest
Dosages and
Formulation( s )
Tolerance, Use, Limitations
Bulk Soil (Potting Soil, Top Soil ) cluster (continued)
/40006KA
NAB AAAA
F1(ADQ BB
IMAAAJA
PA.AAAAA
/400080A
NAB MAA
FKADQBB
IMAAAJA
PAAAAAA
4 lb/lO0
cu. ft
(injection
point /100
cu.ftJ
(98%, 99%,
99.75%, 100%
PrG s)
Mulch (Hay, Manure, Straw )
Seed and Transplant
Nema todes
Soilborne fungi
Soilborne insects
Weeds
1 lb/4 bales
(98%, 99.5%,
100% PrGs)
Beds (nonfood)
180—872 lb/A
(33%, 45%,
50%, 57%,
66%, 67%,
68.6%, 70%,
75%, 80%,
88.2%, 98%,
99%, 99.5%,
99.65%,
99.75%,
99.8% 100%
PrGa)
General soil fumigation of potting
mixes in flats. Arrange the flats
in loose criss—cross stacks no more
than 5 feet high, then cover and
seal. Introduce the fumigant into
evaporating pans or by means of the
hot gas method.
Straw or hay should be thoroughly
soaked several days prior to treat-
ment since seeds must be moist at
time of fumigation for best results.
At the time of treatment, the bales
should be piled up and covered with
a plastic cover with edges sealed
in the same manner as recoended
for soil.
111—053201—23
—125—
Nematodes
Soilborne fungi
Soi].borne insects
Weeds
Fumigation of mulches.
Preplant soil fumigation of seed and
transplant beds.
Issued: 3—07—84
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
( Noncrop, Wide Area, and General Indoor/Outdoor Treatments )
/670020A Recreational Areas (including
Athletic Fields, Golf Courses
and Parks )
Refer to (Ornamental Plants and Forest Trees),
Ornamental Lawns cluster for use and limitation
information.
GREENHOUSE FOOD CROP
General Warnings and Limitations : The use of methyl bromide in confined
spaces presents a potential hazard to humans and plant life. Special pre-
cautions must be made in order that these potential hazards be minimized.
It is the responsibility of the individual supervising the fumigation
operation to see that all safety precautions below are strictly observed:
a) Before the fumigation operation co=ences, the supervisor of the fumi-
gation job shall have conducted proper training of all personnel in-
volved in the fumigation (includes use of safety equipment), removed
all persons from the area not directly involved in the fumigation, and
inspected the equipment to insure proper aeration.
b) If a wind is blowing, all injection should be made upwind from a pre-
vious injection site. limnediately after injection of the fumigant and
tarping, a qualified person wearing protective equipment, should moni-
tor the area with a halide leak detector. U excessive leaks are
found, the source of the leak should be resealed iximediately.
c) During this operation, all windows and doors should be open and fans
operating to maximize ventilation. The fumigated area must be placard—
ad on all entrances with signs containing at least the signal word
DANCER and the “Skull and Crossbones” and the words, “Area under fumi-
gation, do not enter until completely aerated”, the date of fumigation,
name of the fumigant used, emergency telephone number for contact, and
the name and address of the fumigator. Do not remove warning signs
until the fumigated area is completely aerated and safe for entry, as
indicated by a suitable detector. Exposure time should be 24 to C .8
hours.
Refer to TERRESTRIAL FOOD CROP, General Warnings and Limitations for Soil
Fumigation Methods.
Issued: 3—07—84 111—053201—24
—126—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest
Dosages and
Forniulation( 5 )
Tolerance, Use, Limitations
40 ppm (in combination with chloro—
picrin)
Preplant soil fumigation of green-
house grown crop through 240 pounds
per acre.
NAB AAAA
F ADQBB
IMAAAJA
PAAAAAA
Nematodes
Soilborne fungi
Soilborne insects
Weeds
165—240 lb/A
or
9.5—13.8 lb/
2500 sq.ft
(66%, 98%,
99%, 99.5%,
99.65%,
99.75%, 100%
PrGs)
GREENHOUSE NON—FOOD CROP
General Warnings and Limitations : Refer to GREENHOUSE FOOD CROP General
Warnings and Limitations.
/28084CA
NABAAAA
FKADQ BB
IMAAAJA
PAAAAAA
Nema todes
Soilborne fungi
Soilborne insects
Weeds
180—435 lb/A
or
10.3—25 lb/
2500 sq.ft
(98%, 99%,
99.5%,
99.65%,
99.75%,
99.8%, 100%
PrGs)
Issued: 3—07—84
111—053201—25
—127—
( Agricultural Crops )
/11005CA Tomato
Preplant soil fumigation of green-
house grown crop.
(Agricultural Crops)
Forest
Trees)
(Ornamental Plants and
Nonfood/Nonfeed Crops
(Greenhouses)
Preplant soil fumigation of nonfood/
nonfeed crops grown in greenhouses.
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation( s)
DOMESTIC OUTDOOR
( Household )
/630030A Domestic Dwellings (Outdoor )
ISASAAA Ants 1 lb/ant Fumigation of ant colonies. Apply
colony to individual mounds. Do not apply
(98 , lOOt near fruit trees.
PrCs)
( Wood or Wood Protection Treatment )
Fumigation of plant stakes for
‘clean—up’ prior to use. Treat un-
der tarp. Allow a minimum exposure
time of 48 hours. Consult local
County Agricultural Extension Ser-
vice for additional directions and
instructions.
INDOOR
General Warnings and Limitations :
For structural fumigation : At temperatures below 60 F (15.6 C), increase
the dosage by 0.5 pound per 1,000 cubic feet for every 10 F (5.6 C) drop
in temperature or use an approved procedure to heat the fumigant. Do not
fumigate when temperature is below 50 F (10.0 C).
Claims for control of stored product pests and structural pests will also
control rats and mice. When rodenticide claim is solely the object of
fumigation, dosages are usually lower.
Overdosing, overexposure or repeated fumigation of food or feeds tuff com-
modity should be avoided. When the prior history is not known, or in
those instances where a repeated fumigation is necessary, the commodity
should be analyzed for inorganic bromide residues before fumigation to
make certain the proposed treatment will not result in residues that will
exceed the tolerances established. Special care must be exercised to
determine that methyl bromide fumigation of commodities such as animal
feeds, flour, dried eggs, dried figs, dried milk, nuts, meats and meat
products will not result in residues in excess of established tolerances.
When used for fumigation of enclosed spaces, 2 persons trained in the use
of methyl bromide must be present at all times during introduction of the
fumigant, testing, and aeration periods.
Stored Cosmiodity/Product Fumigation Methods :
Unless otherwise specified in the use paragraph, use 1 of the following
methods.
111—053201—26
—128—
/640040A Wooden Plant Stakes
NAB AAAA
FXADQ BB
tMAAAJA
PAAAAAA
Nematodes
Soi].borne fungi
Soilborne insects
Weeds
3 lb/1,000
cu. ft
(98%, 99.5%,
100% PrGs)
Issued: 3—07—84
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations (continued)
I. Chamber Fumigation
Load the chamber with the material to be fumigated, close exhaust
ports, turn on circulating fan and close chamber door. Determine the
proper rate of application and exposure time. Vaporize the liquid in
the chamber by spraying it into the air stream in front of a blower
or fan, passing it through a vaporizer, or allowing it to evaporate
from a shallow pan.
Before introducing the fumigant, place warning signs and a red warning
light on the door. Two people wearing full—faced gas masks with an
approved black canister for organic vapors should be present when in-
troducing the fumigant and opening the door after fumigation. All
controls should be outside the chamber.
At the end of the exposure period, aerate by opening the exhaust port,
turning on the exhaust fan and opening the chamber door slightly to
permit fresh air to enter.
Always check completeness of aeration with detection devices before
allowing unprotected persons to enter the chamber.
2. Vacuum Chamber Fumigation
a) Place material to be fumigated in the steel chamber and draw the
desired vacuum.
b) Release fumigant into the chamber (usually through a heating unit
to insure complete vaporization).
c) At the end of the exposure time, release the vacuum and change the
air in the chamber at least 2 times. A vacuum of 15 inch mer-
cury should be drawn for this purpose.
3. Truck, Van or Trailer Fumigation — Closed Top Conveyances
a. Seal the off—side door, ventilators and other openings from the
inside.
b. Use a closed—ended, perforated tube to distribute fumigant evenly.
Secure the tube to the ceiling so the perforations direct fumigant
toward the floor and prevent it from spraying the ceiling. Always
apply fumigant from outside the truck, van or trailer.
c. Seal the door and place warning signs on both sides of the truck,
van or trailer. Fumigated areas must be placarded on all entranc-
es with signs containing at least the signal word DANGER and the
“Skull and Crossbones” and the words “Area under fumigation, do
not enter until completely aerated,” the date of fumigation, name
of the fumigant used, emergency telephone number for contact, and
the name and address of the fumigator. Do not remove warning
signs until the fumigated area is completely aerated and safe for
entry, as indicated by a suitable detector.
d. Do not fumigate while strong winds are blowing.
e. After 12 to 18 hours, open the unit and aerate 1 to 1.5 hours.
The truck, van or trailer may then be resealed for shipment.
f. Advise consignee to check the truck, van or trailer for proper
aeration on arrival. Do not move trucks, vans or trailers during
Issued: 3—07—84 111—053201—27
—129—
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations (continued)
fumigation. They must be completely aerated before movement is
allowed.
4. Truck, Van or Trailer Fumigation — Open Top Conveyances
a) Park trailer or van out of traffic area—if possible on the lee
side of a building to protect from winds.
b) Roll back the protective tarpaulin to expose the bulk grain or
other commodity.
c) Prepare a gas expansion dome by placing several cardboard boxes,
empty 5—gallon pails or other propping materials on the top of the
load down the center line. These props should be high enough to
support the tarpaulin 12 to 18 inches at the center line above the
grain or commodity surface after replacement.
d) Place 2 shallow, plastic or nonaluminum metal, containers on the
center line grain surface of the load at points 0.3 and 0.6 the
distance from the front of the conveyance. Direct into and firmly
attach with tape 1 end of a 0.25 inch I.D. polyethylene applicator
hose into each evaporating container to prevent liquid methyl bro-
mide from contacting the commodity. Hang the other end of each
hose over the side of the conveyance down to approximate waist
height from the round. The ends of the hoses should have a brass
fitting for attaching to the applicator.
e) Pull the tarpaulin back over the load, covering the props thereby
creating the gas expansion dome. Do not tie down the tarpaulin
but leave sufficient room to tape the gasproof cover to the con-
veyance sides below the edges of the tarpaulin.
f) With the 4 or 6 mu polyethylene or other gasproof cover, com-
pletely over—cover the protective tarpaulin to extend down the
sides of the container. Clean the containers of dirt and grease.
With two—inch masking tape, seal the entire edge of the gasproof
cover to the sides and ends of the container, below the tarpaulin,
leaving the ends of the 2 applicator hoses exposed for attaching
the applicator.
g) Do not occupy truck cabs, van cabs or trailer attached tractor
cabs during exposure and aeration periods. Lock the tag cab doors
during the exposure and aeration periods.
h) CLEAR THE IMMEDIATE WORKING AREA OP ALL UNAUTHORIZED PERSONNEL.
Release one—half of the reco=ended dosage through each of the
applicator tubes, from the applicator. Methyl bromide boils at
39 F (3.8 C). -
i) Following release of the methyl bromide and disconnection from the
applicator, tape the open end of the applicator hose with masking
tape and fasten the hose to the side of the conveyance.
j) Using a halide gas detector, check for fumigant leaks at all taped
margins and at the floor of the conveyance. Seal any point where
flame color readings from the faint green to blue—green indicate
methyl bromide leakage.
Issued: 3—07—84 111—053201—28
-130—
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations (continued)
k) Securely attach the proper methyl bromide fumigation warning
placards to each side and to the ends of the conveyance during
the fumigation and aeration period.
1) Do not move the vans, trucks and trailers during the exposure
period of 12 to 24 hours. At the end of the exposure period,
working in a well—ventilated area and from ground level only, un-
seal the taped edges and remove the gasproof cover. Also working
from ground level only, starting with the downwind end first, peel
back the protective tarpaulin cover toward the center of the con-
tainer to expose the commodity load surface at each end. Do not
remove warning placards until aeration has been completed.
UPON COMPLETION OF THE AERATION PROCEDURE, THE PROFESSIONAL FUMI-
GATOR IS RESPONSIBLE FOR THE RELEASE OF THE CONVEYANCE AND COMMO-
DITY.
5. Railroad Car Fumigation
a) Car should be placed on seldom used trackage or siding so that it
will not have to be moved while under fumigation.
b) Methyl bromide must always be applied from outside the railroad
car by means of a 0.25 inch copper or plastic tubing attached to a
special can puncturer or to a methyl bromide cylinder. The tube
may be introduced into the car through a hole drilled in the floor
near the center of the car or through some other convenient hole
such’ as a crack in the door or some roof opening. The discharge
end of the tube should be secured near the ceiling at the center
of the car. This may be accomplished by fastening the tube to a
pole, stick or some other support that may be propped up to hold
the end of the tube near the ceiling. The discharge end of the
tube is plugged and a hole drilled through the opposite walls or
the tube about 1 to 2 inches below the tip to permit escape of the
methyl bromide mist above the commodity load and toward the
opposite ends of the car.
c) All car openings should be carefully sealed. Particular attention
should be given the space around doors, the eaves, and the floor.
During application and fumigation, all openings used to introduce
the gas tube should be tightly sealed up to and surrounding the
tube. Any holes bored through the car structure should be of a
minimum size and carefully sealed following fumigation. Masking
tape, caulking compound or greased paper may be used as sealing
materials.
d) Post warning signs conforming to Department of Transportation
regulations on both doors before applying methyl bromide.
e) Methyl bromide may be applied by using special measuring devices
that can be attached to the cylinders. Always wear safety glasses
when working with methyl bromide.
f) After application of the proper dosage, withdraw the tubing and
seal the hose used for application. Keep the car sealed for 12
to 18 hours. A halide detector may be used to check sealed areas
Issued: 3—07—84 111—053201—29
—131—
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations (continued)
for leaks. The fumigated car should not be moved during the ex-
posure period.
g) At the end of the fumigation period, open all doors and vents to
allow as much air circulation as possible. It will usually re-
quire about 30 minutes to aerate a car after fumigation but this
must be determined by the use of a halide detector. Keep all per-
Sons out of the car during fumigation and aeration and until such
time as the halide detector shows no methyl bromide present. Only
then is it safe to enter the car without wearing respiratory pro-
tection.
6. Grain Elevator Fumigation
The recirculation method is best for grain elevator fumigation since
it allows more time for gas penetration in high resistance areas.
a) Seal structure carefully, using masking tape for small openings
and polyethylene sheeting secured with masking tape for large
openings.
b) Fumigated areas must be placarded on all entrances with signs con-
taining at least the signal word DANGER and the “Skull and Cross-
bones” and the words “Area under fumigation, do not enter until
completely aerated”, the date of fumigation, name of the fumigant
used, emergency telephone number for contact, and the name and
address of the fumigator. Do not remove warning signs until the
fumigated area is completely aerated and safe for entry, as mdi-
cated by a suitable detector.
c) Use the rate and exposure time shown in site entries for specific
grains to be treated.
d) Fumigate by using a fan or blower to recirculate the methyl bro-
mide through the perforated pipes or ducts at the bottom of the
bin, up through the return duct. Or discharge the fumigant
through polyethylene tubing in the head space at intervals of 100
feet or less.
e) Check periodically for leaks with a halide gas detector.
f) To aerate after fumigation, disconnect return air at the fan and
discharge into outside air. Continue aeration until halide detec-
tor shows the fumigant has dissipated. Use halide detector to
check the elevator head space for possible pockets of methyl bro-
mide.
7. Tarpaulin Fumigation
a) Arrange the stacks, gas expansion dome, tubing and evaporating
pans and tarpaulin. Follow these directions:
The stack : Stacks of stored commodities usually can be fumigated
where they stand as long as the tarpaulin is large enough to cover
the stack completely. Be sure to allow for a tarpaulin margin of
at least 2 feet around the stack when the cover is laid over it.
The stack should be on a concrete floor or other airtight surface.
Where floors are not airtight (such as on a loading dock) cracks
Issued: 3—07—84 111—053201—30
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METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations (continued)
should be caulked or otherwise sealed to prevent escape of the
fumigant. Sisal kraft paper, tar paper, or additional tarpaulin
laid on the floor under the material to be fumigated will provide
a satisfactory seal.
The gas expansion dome : Center 4 or more sacks upright on top of
the stacked material to form a gas expansion dome. This facili-
tates gas distribution.
The tubing and evaporating pans : Copper, polyethylene, or saran
tubing is used to inject the gas near the center of the expansion
dome. The outlet of this tubing should be fastened to an evapo-
rating pan to prevent liquid methyl bromide from dripping on the
commodity being fumigated, or splashing on the tarpaulin.
The tarpaulin : Polyethylene or gas proof, impregnated, tarpaulins
should be used. Water—proofed canvas tarpaulins are not satisfac-
tory. Before spreading the tarpaulin, sweep around the stack to
provide a clean surface for sealing. Unroll or unfold the tarpau-
lin over the stack, providing a margin on the floor of 2 or feet.
Run the applicator tubing out from under the tarpaulin at a cor-
ner, which should be folded. Seal the tarpaulin by weighting it
down with a row of bagged material or sand—filled tubes. (Canvas
or plastic tubing about 4 inches in diameter may be used for these
sandsnakes.)
b) Once the above preparations are completed, fumigation can be done.
Attach the applicator tubing to the cylinder of methyl bromide.
Place warning placards on tarpaulins under fumigation. These
place cards must be present during aeration. Leave the stack un-
disturbed for 24 hours after releasing the fumigant.
8. Shipboard, In Transit or Shiphold Fumigation
Shipboard, in transit ship or shiphold fumigation is also governed by
United States Coast Guard Regulations. Refer to and comply with these
regulations prior to fumigation.
Pre fumigation Procedures
a) Prior to fumigating a vessel for in transit cargo fumigation, the
master of the vessel or his representative, and the fumigator must
determine whether the vessel is suitably designed and configured
so as to allow for safe occupancy by the ship’s crew throughout
the duration of the fumigation. If it is determined that the de-
sign and configuration of the vessel does not allow for safe occu-
pancy by the ship’s crew throughout the duration of the fumiga-
tion, then the vessel will not be fumigated unless all crew mem-
bers are removed from the vessel. The crew members will not be
allowed to reoccupy the vessel until the vessel has been properly
aerated and a determination has been made by the master of the
vessel and the fumigator that the vessel is safe for occupancy.
b) The person responsible for the fumigation must notify the master
of the vessel, or his representative, of the requirements relating
Issued: 3—07—84 111—053201—31
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METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations (continued)
to personal protection equipment, detection equipment and that a
person qualified in the use of this equipment must accompany the
vessel with cargo under fumigation. Emergency procedures, cargo
ventilation, periodic monitoring and inspections, and first aid
measures must be discussed with and understood by the master of
the vessel or his representative. Personal protection equipment
means a self contained breathing apparatus (SCBA) or combination
air—supplied/SCBA respirator approved jointly by the National
Institute of Occupational Safety and Health (NIOSH) and the Mine
Safety and Health Administration (MSHA).
c) Fumigated areas must be placarded on all entrances with signs con-
taining at least the signal word DANGER and the “Skull and Cross-
bones” and the words “Area under fumigation, do not enter until
completely aerated”, the date of fumigation, name of the fumigant
used, emergency telephone number for contact, and the name and
address of the fumigator. Do not remove warning signs until the
fumigated area is completely aerated and safe for entry, as indi-
cated by a suitable detector.
d) During the fumigation or until a manned vessel leaves port or the
cargo is aerated, the person in charge of the fumigation shall in-
sure that a qualified person using gas or vapor detection equip-
ment tests spaces adjacent to spaces containing fumigated cargo
and all regularly occupied spaces for fumigation leakage. If
leakage of the fumigant is detected, the person in charge of the
fumigation shall take action to correct the leakage, or shall in-
form the master of the vessel, or his representative of the leak-
age so that corrective action can be taken.
e) If the fumigation is not completed and the vessel aerated before
the manned vessel leaves port, the person in charge of the vessel
shall insure that at least 2 units of personal protection equip-
ment and 1 gas or vapor detection device, and a person qualified
in their operation be on board the vessel during the voyage.
Precautions and Procedures During Voyage
Using appropriate gas detection equipment, monitor spaces adjacent to
areas containing fumigated cargo and all regularly occupied areas for
fumigant leakage. If leakage is detected, the area should be evacuat-
ed of all personnel, ventilated, and action taken to correct the leak-
age, before allowing the area to be occupied, Do not enter fumigated
areas except under emergency conditions. If necessary to enter a fu-
migated area, appropriate personal protection equipment must be used.
Never enter fumigated areas alone. At least 1 other person, wearing
personal protection equipment, should be available to assist in case
of an emergency.
Precautions and Procedures During Discharge
If necessary to enter holds prior to discharge, test spaces directly
above grain surface for fumigant concentration, using appropriate gas
Issued: 3—07—84 111—053201—32
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations (continued)
detection and personal safety equipment. Do not allow entry to fumi-
gated areas without personal safety equipment, unless fumigant concen-
trations are at safe levels, as indicated by a suitable detector.
9. Warehouse, Structural and Food Plant Fumigation
Check with appropriate municipal and county authorities before fumi-
gating to be completely familiar with local regulations. Ordinances
may require watchmen, padlocks, or warning posters during and after
fumigation and/or notification of the nearest fire station. Notify
anyone who would normally be in the area before fumigating. Several
types of buildings can be fumigated with methyl bromide. Frame, metal
and concrete buildings used for storage of agricultural products can
be fumigated if they are in good repair and tight, or can be made
tight by sealing or tarping. The buildings include packing plants,
grain elevators, milling and baking plants, port warehouse grain stor-
age buildings, coffee warehouses. Cement blocks pose a special prob-
lem because of their porous nature, but can be fumigated if an in-
creased do8age and exposure time is allowed to compensate for the dif-
fusion loss. There is no rule of thumb allowing for leakage. The ap-
plicator will have to exercise judgement from his observation of the
building’s condition.
a) The most important part of the entire fumigation job lies in the
preparation and sealing of the structure.
The properties of penetration and diffusion that make methyl bro-
mide an ideal fumigant also make it difficult to confine—and for
that reason, a good sealing job is necessary. High winds, for
example, increase fumigant loss and cause fumigant to drift to the
leeward side of the building.
Sealing of the building begins with the closing of all external
openings to the building. Seal roof ventilators and chimaeys by
wrapping them with tarpaulin, or plastic sheet, or by stripping
the screened openings with a wide commercial masking tape.
Stairwells and interior doors should be closed. Any broken panes
should be replaced, then exterior doors and windows should be
wedged tight, locked, and cracks caulked or taped. Check for
cracks in the floor, roof, and around eaves and seal them.
Special care should be taken to seal partitions to adjacent stor-
age or work areas in a building. Adjoining buildings sharing a
coon wall must be cleared of personnel, animals, and items that
will react to methyl bromide or commodities which might be damaged
by exceeding the established tolerances for inorganic bromide,
before fumigation. If this is not feasible, spread a glossy type
building paper, Sisalkraft or asphalt laminated paper, plastic
film, or a heavily oiled kraft or wrapping paper to prevent spread
of the fumigant into undesired areas. In all such cases where the
adjoining building is occupied, it should be checked frequently
with a halide detector during fumigation to insure the safety of
Is sued: 3—07—84 111—053201—33
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METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations (continued)
the occupants. Check local regulations for specific requirements.
Appearance, economy and ease of cleanup will probably determine
your choice of sealing materials.
Where time and neatness are factors, masking tapes and commercial
caulking compounds will probably justify their extra cost. It is
possible, however, to make your own paste by combining lubricating
oil and a low grade of flour.
Because methyl bromide gas can penetrate accumulations of trash
and sweepings, necessary cleanups may be postponed until after the
fumigation has been completed. It is recommended that all doors
and hatches on milling machinery be opened. These include eleva-
tor boots and repair openings, conveyor lids, settling chamber
doors and dust trunks. This also applied to reels, purifiers,
sifters, shorts and bran dusters, feeder gates on rolls and puri-
fiers as well as other openings that will facilitate the entrance
of gas to the equipment. Dead spouts are particularly difficult
to penetrate and should be opened before the fumigation.
b) Dosage recommendations are made on the basis of cubic content.
In square or rectangular buildings simply multiply the interior
length by width by height. In irregular shaped buildings, find
the cubic content of each unit, then add them together to find the
total. In the case of peaked roofs, the average height between
sidewall and the top of the roof may be used as the third multiple
in calculating the cubic content.
In taking measurements, no deductions should be made for space
occupied by machinery, commodities or furnishings. Exceptions to
this rule apply to fresh fruits and vegetables.
c) Cylinders should be placed by a two—man team, using a clipboard
to map the location of each cylinder in the building. The cylin-
ders should be arranged so that the fumigator will start releas-
ing the gas on the top floor and continue walking away from the
released gas in the direction of the exit as he opens each subse-
quent cylinder.
As methyl bromide is heavier that air, it is advisable to overdose
the top floor slightly. In all cases, the size of cylinder can
quite naturally follow the needed dosage for that particular cubic
space. Cylinders should be located within a room so as to do the
best job of diffusion into all areas. Cylinders should be set in
an upright position and the shipping caps removed. Again, since
methyl bromide is heavier than air, in order to prevent stratifi-
cation at the lower levels, it is sometimes advisable to attach
standpipes (or curved pipes directed upward) to the cylinder
valves. If standpipes are used, they should be equipped with T
fittings to direct the gas laterally and prevent direct contact.
Issued: 3—07—84 111—053201—34
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations (continued)
d) At this point, a practice session should be undertaken to famil-
iarize the operators with the location of each cylinder and the
sequence in which it is to be discharged. With gas masks at ready
position, quickly open and close the cylinder valves to make cer-
tain they are in working order and thus avoid delay during the
actual release.
If fans are to be used, they should be strategically located and
made ready to switch on or off from outside the building. One 16
inch fan for every 50,000 cubic feet of space will be sufficient.
Quite often, however, it is possible to use heating fans or other
installations already in the building.
Extinguish all open flames and turn of all high temperature elec-
trical equipment including laboratory ovens, pilot lights, gas
refrigerators, oil burners, etc. Presence of intense heat from
such sources may change methyl bromide to hydrobromic acid which
may be injurious to coim odities and equipment.
Place warning signs on all entrances to the building. Have lights
to illuminate warning signs plainly. Inform police, fire and
health officials that a fumigation process is about to begin.
Observe location of nearest telephone for use in case of emergen-
cy.
Make sure fumigators can recognize early symptoms of methyl bro-
mide intoxication and that the appropriate physicians and hospi-
tals have been provided a copy of “First Aid & Treatment for
Methyl Bromide Exposure”.
Arrangements should be made to seal and bar the building entrances
as soon as the job is complete. Watchmen should take up their
stations to prevent any admittance during the fumigation.
e) At this point, gas masks should be donned, carefully checked, and
the cylinders opened. Under no circumstances should the operators
be in the building longer than 30 minutes in releasing the gas.
If it is impossible for 1 crew to do it within this time period,
additional experienced crews should be used. Two persons trained
in the use of methyl bromide must be present at all times during
introduction of the fumigant, testing, and aeration periods.
Thus, in case 1 should become incapacitated for any reason, such
as an accidental fall that would result in an injury or uncon-
sciousness, the other man could remove him to fresh air. These
men should always remain close to each other from the time they
open the first cylinder until the time they leave the building
together. While the first 2 are in the building, it is advisable
to have 2 additional men, with gas masks ready, waiting at the
exit to aid if needed. When releasing fumigant, start on the top
floor and work toward exits. Where there is a basement, the gas
should be released there iuunediately prior to releasing the gas
on the ground floor. One man should check off locations of each
cylinder so none are missed.
Issued: 3—07—84 111—053201—35
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
General Warnings and Limitations (continued)
All fans should be running while the gas is being released and
left running until uniform distribution has been accomplished,
which should not require more than 30 minutes to 1 hour. After
this the fans should be turned off.
f) Once the exposure period is complete, aeration should be started
by opening the previously prepared doors and windows on the ground
floor. Where ventilators are accessible from the outside they
should also be opened at this time. The ground floor should be
allowed to aerate until a halide leak detector shows that the
methyl bromide concentration has diminished to the point where the
detector shows no more than dark green. At this point, at least
2 men, wearing gas masks, should begin opening windows, starting
at the bottom and working upward. These men should not try to
open all windows on any single floor the first time through but
should open only those windows that are necessary for thorough
ventilation and return to the outside as soon as possible. They
should not remain inside the building for prolonged periods (not
more than 15 minutes). The fans should be turned on once again
and allowed to run until aeration is complete. After the building
has been partially aerated, the men, again wearing masks, should
open as many of the remaining windows as needed to complete the
aeration. No one should be allowed inside the building without a
gas mask until all parts of the building have been checked with a
halide detector for methyl bromide concentration and the flame
shows no change in color at any point. Once the aeration has been
completed, usually in 2 or 3 hours, the building can be returned
to normal condition for operation. Where possible, it is advis-
able to leave in place such sealing as will not hinder aeration
and operations so that this sealing does not have to be replaced
for future fumigations.
10. Recircu].ation Method
With recirculation, dosages can be reduced as much as 50 percent to
70 percent below those recommended because of more efficient use of
the fumigant. Bulletins are available for dose and use recommenda—
t ions.
Exposure Period for Stored Commodity Fumigation :
Unless otherwise specified, expose the treated coimnodities for a period
of 12 to 24 hours.
Issued: 3—07—84 111—053201—36
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest
ForTnulation( a )
Tolerance, Use, Limitations
( Agricultural Crops )
/23001.EA
General Warnings and Limitations :
moisture content above 14 percent
gate if grain moisture is: high or
(15.6 C) or if there is excessive
Alfalfa (Hay )
F .uuigation of stored grain with
may injure germination. Do not fumi—
if grain temperature is below 60 F
dockage.
50 ppm
Stored commodity fumigation through
3 pounds per 1,000 cubic feet.
3 lb/l,000
cu.ft
(98%, 100%
PrGs)
EMAAAFA
Stored product
insects
2 lb/l,000
Cu. ft
(100% PrGs)
Stored commodity fumigation.
for 16 to 24 hours.
Expose
/ 03004EA
IMAAAFA
(Chestnut)
Stored product
insects
3.5 lb/1,000
c i i. ft
(98%, 100%
PrGs)
200 ppm
Stored commodity fumigation through
3.5 pounds per 1,000 cubic feet.
0.25 lb/l,000 Stored commodity fumigation. Expose
cu.ft for 12 to 18 hours.
(100% PrGs)
1 11—05320 1—37
—139—
INASBWA
INAMCMA
Alfalfa weevil
Cereal leaf beetle
Stored commodity fumigation. Expose
for 24 hours.
IO30 0IEA
/03002EA
/ 0301 OEA
/03003EA
/03004EA
/03005EA
/03007EA
/28O15EA
/ 03008EA
I 03 01 lEA
/03009EA
Almond
Brazil Nut
Butternut
Cashew
Chestnut
Filbert (Hazelnut)
Macadamia Nut (Bushnut)
Peanuts
Pecan
Pistachio
Walnut
IMAAAFA Stored product
insects
1—3.5 lb/
1,000 cu.ft
(98%, 100%
PrGs)
Stored commodity fumigation.
Stored commodity fumigation.
for 24 hours.
/28015EA
VKGAAAA
(Peanuts)
Rodents
Expose
Issued: 3—07—84
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest s and Tolerance, Use 1 Limitations
Forinulation( s )
/04001.EA Apple 5 ppm
/04003EA Pear Postharvest coiodity fumigation
/ 06004EA Quince through 5 pounds per 1,000 cubic
/O500 1EA feet 0
/05002EA
/ OSOO3EA
/05004EA
/05005EA
ENASECA Apple curculio 5 lb/1,000 Postharvest coimnodity fumigation.
IOBMAQA Apple maggot cu.ft Expose for 2 hours.
ILAVACA Brown mite (98%, 100%
IOBMALA Cherry fruit fly PrGs)
ITBGAZA Codling moth
I1 ACCUA Green peach aphid
IOBMADA Mediterranean fruit
fly
IOBMAEA Melon fly
IOBMAFA Oriental fruit fly
ITBGAQA Oriental fruit moth
IRAAABA Scales
IMOAAAA Thrips
IZZZDMA Twig borers
/O500IEA Apricot 20 ppm
Posthar’vest coimnodity fumigation
through 5 pounds per 1, 000 cubic
feet.
Refer to Apple cluster.
/ 14009EA Artichoke (Jerusalem ) 30 ppm
Postharvest commodity fumigation
through 3.5 pounds per acre.
ETBCCFA Armyworm 3.5 lb/1,000 Postharvest commodity fumigation.
ENBCAAA Blister beetles cu.ft Expose for 4 hours.
ETBCBOA Corn earworm (98%, 100%
tNAI4ACA Cucumber beetles PrGs)
INBPAZA Japanese beetle
ITAAAOA Loopers (including
cabbage looper)
IQAMARA Lygus bugs
IRAWA.AA MeaI.ybugs
IIFAAEA Sowbugs
ELAVAAA Spider mites
IQAQA.AA Stink bugs
IJDAAAA Syinphylans
Issued: 3—07—84 IIF O532Ol 38
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation( s )
/28063EA Bane ! 50 ppm
Stored commodity fumigation through
6 pounds per 1,000 cubic feet.
INATANA Khapra beetle 6 lb/l,000 Stored commodity fumigation. Expose
cu.ft for 12 hours. Use in accordance
(100% PrCs) with the plant quarantine program of
the United States Department of
Agriculture.
VKGAAA Rodents (including 0.25 lb/1,000 Stored commodity fumigation. Expose
house mouse, cu.ft for 16 to 24 hours.
Norway rat and (99%, 100%
roof rat) PrGs)
LMAAAFA Stored product 3—4 lb/1,000 Stored coodity fumigation. Expose
insects cu.ft for 12 to 24 hours.
(98%, 99%,
99.5%,
99.65%,
99.75%,
99.8%, 100%
PrG s)
5—6 lb/l,000 Stored coiwnodity fumigation. Expose
cu.ft for 12 hours.
(100% PrCs)
/ 15027EA Beans 50 ppm (for beans, green beans, liTna
beans and snap beans)
Postharvest cotodity fumigation
through 3.5 pounds per acre.
ITEMM.A Almond moth 3 lb/l,000 Stored commodity fumigation. Expose
INAGAGA Cowpea weevil cu,ft for 12 hours.
(100% PrGs)
ITBCCFA Armyworin 3.5 lb/1,000 Postharvest commodity fumigation.
INAMARA Bean leaf beetle sq.ft Expose for 24 hours.
IN GAAA Blister beetles (98%, 100%
ITBCB OA Corn earworm PrGs)
INAGAGA Cowpea weevil
INANACA Cucumber beetles
(including Dia—
brotica beetle)
INBUAAA Darkling beetles
IMDAAAA Earwigs
ITBMCCA European corn borer
INBPAZA Japanese beetle
Issued: 3—07—84 111—053201—39
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Tolerance, Use, Li
Formulation(s)
Beans (continued)
Pest list continued from previous page
ITAAAOA Loopers (including
cabbage looper)
IQAX&RA Lygus bugs
IRAWAAA Mealybugs
INAPAPA Mexican bean beetle
T.IIOCAVA Onion thrips
ITBM&WA Pickleworm
IIFAAEA Sowbugs
ILAVAAA Spider mites
IQAQAAA Stink bugs (includ-
ing green stink
bug)
IJDAAAA Syinphylans
IMAAAFA Stored product 1—2 lb/l,000 Stored commodity fumigation. Expose
insects cu .ft for 12 to 24 hours.
(98%, 100%
PrCa)
/28002EA Beets (Roots ) 30 ppm (roots, garden and sugar)
/28020EA j je s Postharvest cOmmodity fumigation
through 3 pounds per 1,000 cubic
feet
ITBCCFA Artnyworm 3 lb/l,000 Postharvest commodity fumigation.
ENBGAAA Blister beetles cu.ft Expose for 4 hours.
ICACADA Cabbage maggot (98%, 100%
tNAMACA Cucumber beetles PrGs)
ThIDAAAA Earwig s
ITBMCCA European corn borer
IQALAHA False chinch bug
INBPAZA Japanese beetle
ITAAAOA Loopers (including
cabbage looper)
IQAMA RA Lygus bugs
IRAWAAA Mealybugs
IRACAOA Melon aphid
IIPAAEA Sowbugs
tLAVAAA Spider mites
IQAQAAA Stink bugs
tJDAAAA Symphylans
Brazil Nut See Almond cluster.
Butternut See Almond clusterb
Issued: 3—07—84 111 —053201 —40
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s )
/ 130 07EA Cabbage 50 ppm
Postharvest commodity fumigation
through 4 pounds per 1,000 cubic
feet.
ITBCCFA Armyworm 4 lb/l,000 Postharvest commodity fumigation,.
INBGAAA Blister beetles cu .ft Expose for 4 hours. Use in acco rd
IOACADA Cabbage maggot (98%, 100% ance with the plant quarantine pro—
INAMCFA Colorado potato PrGs) gram of the United States Department
beetle of Agriculture.
ITBC BOA Corn earworm
INAMACA Cucumber beetles
(including Dia—
brotica beetle)
INBUA.AA Darkling beetles
INDAAAA Earwigs
EQALAHA False chinch bug
INBPAZA Japanese beetle
ETAAAOA Loopers (including
cabbage looper)
EQAMARA Lygus bugs
IRAWAAA Mealybugs
IMOCAVA Onion thri.ps
IIFAAEA .Sowbugs
ILAVAAA Spider mites
EQAQAAA Stink bugs (includ-
ing green stink
bug)
IJDAAAA Sytnphylans
/ 10002EA Cantaloupe 20 ppm
/I0005EA floneydew Melons Postharvest conmiodity fumigation
/10006EA Musknielons through 2.5 pounds per 1,000 cubic
/100I 1EA Pumpkins feet.
/I0008EA Watermelons
/LOO IOEA
ITBCCFA Armyworm 2.5 lb/l,000 Postharvest cotmnodity fumigation.
INBGAAA Blister beetles cu.ft Expose for 2 hours.
INAMACA Cucuther beetles (982, 100%
(including Dia— PrG8)
brotica beetle)
INBUAAA Darkling beetles
EQALAHA False chinch bug
INBPA2A Japanese beetle
ITA.AAOA Loopers (including
cabbage looper)
IQAMARA Lygus bugs
ERACADA Melon aphid
IMOCAVA Onion thrips
Issued: 3—07—84 111—053201—41
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EPA Compendium of Acceptable Uses
THYL BROMIDE
Site and Pest and Tolerance, Use, Limitations
yoruiulation( s)
Cantaloupe cluster (continued)
Pest list continued from previous page.
ITBMMJA Pickleworm
I IFAAEA Sowbugs
ILAVA A Spider mites
IQAGAFA Squash bug
ITBQADA Squash vine borer
IQAQAAA Stink bugs
IJDAAAA Symphylans
/28073EA Carrots 30 ppm
Postharvest commodity fumigation
through 4 pounds per 1,000 cubic
feet.
IT BCCFA Artnyworm 4 lb/l,000 Postharvest commodity fumigation.
INBGAAA Blister beetles cu,ft Expose for 4 hours.
IOBBABA Carrot ruSt fly (98%, 100%
INAMACA Cucumber beetles PrGs)
INBUAAA Darkling beetles
ETAAAOA Loopers (including
cabbage looper)
IQAMARA Lygus bugs
IRAWAAA Mealybugs
IMOCAVA Onion thrips
IIFAAEA Sowbugs
ILAVAAA Spider mites
IQAQAAA Stink bugs
IJDAAAA Symphylans
Cashew See Almond cluster.
/O5 00ZEA Cherry 20 ppm
Postharvest coodity fumigation
through 5 pounds per 1,000 cubic
feet.
Refer to Apple cluster.
Chestnut See Almond cluster.
Issued: 3—07—84 111—053201—42
—144—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Fortnulation( 8 )
128026EA Citron 30 ppm
Postharvest commodity fumigation
through 3 pounds per 1,000 cubic
feet.
tTBCCFA Armyworm 3 lb/1,000 Postharvest commodity fumigation 0
INBGAAA Blister beetles cu.ft Expose for 2 hours.
INANACA Cucuther beetles (98%, 100%
INBUAAA Darkling beetles PrGa)
IQALA}IA False chinch bug
INBPAZA Japanese beetle
ITAAAOA Loopers (including
cabbage looper)
IQAMARA Lygus bugs
IRAC& OA Melon aphid
ITBMMJA Pickleworin
IIFAAEA Sowbugs
ILAVAAA Spider mites
IQAGAPA Squash bug
ITBQADA Squash vine borer
IQAQAAA Stink bugs
IJDAAAA Syniphylans
/O7001EA Cocoa Beans 50 ppm
Stored commodity fumigat ton through
1.5 pounds per 1,000 cubic feet.
IMAAAFA Stored product 1.5 lb/l,000 Scored commodity fumigation. Apply
insects cu.ft by chamber fumigation. Expose for
(98%, 100% 12 hours.
PrGs)
/28006EA Corn 50 ppm (corn and sweet corn, kernel
plus cob with husk removed)
Stored consnodity fumigation through
6 pounds per 1,000 cubic feet.
INATANA Khapra beetle 6 lb/1.,000 Stored cot iodity fumigation. Expose
cu,ft for 12 hours. Use tn accordance
(100% PrGa) with the plant quarantine program of
the United States Department of
Agriculture.
VKGAAAA Rodents (including 0.25 lb/l,000 Stored commodity fumigation. Expose
house mouse, cu,ft for 16 to 24 hours.
Norway rat and (99%, 1.00%
roof rat) PrGs)
Issued: 3—07—84 111—053201—43
—145—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Fortftulation( s)
Corn (continued)
INAAAPA Stored product 2 lb/l,000 Stored commodity fumigation 0 Expose
insects cu.ft for 12 to 24 hours 0
(98%, 99%,
99. 5%,
99.65%,
99.75%,
99.8%, 100%
PrGs)
4 lb/l,000 Stored commodity fumigation. Expose
cu.ft for 12 hours 0
(98% PrGs)
/ 15004EA Corn, Pop 240 ppm
Stored commodity fumigation through
1.5 pounds per 1,000 cubic feet.
LMAAAFA Stored product 1.5 lb/1,000 Stored commodity fumigation.
insects cu.ft
(98%, 99%,
990 5%,
99.65%,
990 75%,
99.8%, 100%
PrOs)
/15005EA Corn, Sweet 50 ppm (corn and sweet corn, kernel
plus cob with husk removed)
Postharvest coimnodity fumigation
through 3 pounds per 1,000 cubic
feet.
ITBCCFA Arinyvorm 3 lb/1,000 Postharvest coiodity fumigation.
tNANARA Bean leaf beetle cu.ft Expose for 4 hours.
INBGAAA Blister beetles (98%, 100%
IOACADA Cabbage maggot PrOs)
ITBCBOA Corn earworm
INAZ4ACA Cucumber beetles
INBUAAA Darkling beetles
IMDAAAA Earvigs
ITBMCCA European corn borer
IQALAHA False chinch bug
IQAQACA Green stink bug
INBPAZA Japanese beetle
ITAAAOA Loopers
IQAMARA Lygus bugs
IRAWAAA Mealybugs
IIFAAEA Sowbugs
Issued: 3—07—84 111—053201—44
—146—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
Corn, Sweet (continued)
Pest list continued from previous page.
Spider mites
Stink bugs (includ-
ing green stink
bug)
Symphylans
3 lb/l,000
Cu. ft
(98%, 99%,
99.5%,
99.65%,
99.75%’
99.8%, 100%
PrGs)
200 ppm (cottonseed)
Stored coodity fumigation through
4.5 pounds per 1,000 cubic feet.
Stored commodity fumigation. Expose
for 6 hours.
Stored coiodity fumigation. Apply
by atmospheric fumigation. Expose
for 24 hours.
4 lb/l,000
Cu. ft
(98%, 99%,
99.5%,
99.65%,
99.75%,
99.8%, 100%
PrGs)
Stored coodity fumigation. Apply
by vacuum chamber fumigation. Ex-
pose for 2 hours with a sustained
vacuum of 25 to 27 inches (equiva-
lent to a barometric pressure of 3
to 5 inches mercury).
I MAAAFA
Stored product
insects
2.25—4.5 lb/
1,000 cu.ft
[ less than
100,000
cu. ft I
or
1.875—2.25
lb/ I, 000
Cu. ft
(100,000—
500,000
cu .ft]
(98% PrCs)
or
Stored coimnodity fumigation in ware-
houses. Decrasse the dosage by 33
percent when treating unbaled cot-
ton. Expose for 24 hours.
Issued: 3—07—84
111—05 3201—45
—147—
IQAQAAA.
LTD AAAA
/28007EA Cotton (including Baled Cotton)
VXDAAAA
VKCCA.AA
SJKGAAAA
INASAHA
ITAXAOA
Bats
Moles
Rodents
Boll weevil
Pink boliworm
0.25 lb/l,000
cu. ft
(98% PrGs)
-------
EPA Compendium of Acceptable Uses
METHYL BROKIDE
Site and Pest
Dosages and
Formulation( 3 )
Tolerance, Use, Limitations
/27003EA
Cotton (continued)
Cottonseed
1.5—1.875 lb/
1,000 cu,ft
[ 500,000-
1,000,000
cu.ftl
or
1.5 lb/1,000
cu. ft
[ over
1,000,000
Cu. ft]
(98% PrGs)
200 ppm (cottonseed)
Stored commodity fumigation through
8 pounds per 1,000 cubic feet.
Boll weevil
Khapra beetle
Pectinophora cater-
pillars
Sawtoothed grain
beetle
Pink bolluorm
Cigarette beetle 4 lb/l,000
cu. ft
(100% PrGs)
Stored commodity fumigation. For
Khapra beetle and pink bolluorm , use
in accordance with the plant quaran-
tine program of the United States
Department of Agriculture. Expose
for 24 hours.
Stored coimnodity fumigation. Apply
by tarpaulin fumigation. Expose for
24 hours.
30 ppm
Postharvest Commodity fumigation
through 2.5 pounds per 1,000 cubic
feet.
Expose for 4 hours.
Issued: 3—07—84
111—053201—46
—148—
8 lb/l,000
Cu. ft
(98%, 1 .00%
PrGs)
INASAMA
INATANA
ITANkWA
INARACA
ITAMAOA
INABADA
ITBMCHA
/ 100 LOEA
Indianmeal moth
Cucumber
3 lb/t,000
cu. ft
(100% PrGs)
Stored counnodity fumigation.
by vacuum chamber fumigation.
pose for 24 hours.
Apply
Ex-
Refer to Cantaloupe cluster.
-------
EPA Compendium of Acceptable Uses
METWLL BROMIDE
Site and Pest Lafl Tolerance, Use, Limitations
Forinulation( a )
/I1 00 IEA Eggplant 20 ppm
I I10 05EA Tomato Postharvest cot odity fumigation
through 3 pounds per 1,000 cubic
feet. -
ITBCCFA Armyworm 3 lb/l,000 Postharvest commodity fumigation.
tNBGA.AA Blister beetles cu.ft Expose for 4 hours.
tNAMC!A Colorado potato (98%, 100%
beetle PrCs)
ITBCBOA Corn earvorm
tWAMACA Cucumber beetles
(including Dia—
brotica beetle)
INBUA.AA Darkling beetles
rMDAAA.A Earwigs
ITBMCCA European corn borer
INBPAZA Japanese beetle
ITAAAOA Loopers
IQAI4A.RA Lygus bugs
IRAWA.AA Mealybugs
IMOCAVA Onion thrips
IIFAAEA Sowbugs
ELAVAAA Spider mites
IQAQAAA Stink bugs
IJDAAAA Symphyl.ans
Filbert (Hazelnut ) See Almond cluster.
/ 14007EA Garlic 50 ppm
Postharvest commodity fumigation
through 4 pounds per 1,000 cubic
feet.
ILAVAtJA Brown wheat mite 3 lb/1,000 Postharvest co=iodity fumigation.
ITAIAFA Dyspessa ulula cu.ft Expose for 4 hours.
INASHIA Garlic beetle (98%, 100%
EOACACA Onion maggot PrGs)
IMOCAVA Onion thrips
Issued: 3—07—84 111—053201-47
—149—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s )
/ 02002EA Grapefruit 30 ppm
/02003EA K .unguat Postharvest coimnodity fumigation
/02004EA Lemon through 3 pounds per 1,000 cubic
/02005EA Lime feet.
/02006EA Orange Varietal tolerances may vary. Check
/02007EA Tangelo with authorities prior to fumiga—
/02008EA Tangerine tion.
ISASAA.A Ants 3 lb/l,000 Postharvest commodity fumigation.
ERACAAA Aphids cu.ft Expose for 2 hours.
ILAUAPA Brevipalvus mites (98%, 100%
ITBHAH A California orange— PrGa)
dog
IOBMAUA Carribean fruit fly
INAVAWA Conoderus wireworms
IQACAEA Leaffooted bug
IMA.AAEA Leaf rollers
tMASHJA Listroderes weevils
IRAWAAA Mealybugs
INASHNA Megaloinetis weevils
I OBMABA Mexican fruit fly
INASHOA Naupactus weevils
ITBUALA Orange tortrix
tTBUE1 A Proculia moths
ILAVAAA Spider mites
tMQAAAA Thrips
IOBW CA West Indian fruit
fly
IRABAAA Whiteflies
/O1OI4EA Grapes 20 ppm
Postharvest connuodity fumigation
through 4 pounds per 1,000 cubic
feet.
Varietal tolerances may vary. Check
with authorities prior to fumiga-
tion.
ISASAAA Ants 4 lb/l,000 Postharvest commodity fumigation.
IRACA.AA Aphids cu.ft Expose for 2 hours.
I IAtIAPA Brevipalvus mites (98%, 100%
ITBHAHA California orange— PrGs)
dog
IOBMAUA Carribean fruit fly
IMAAAEA Leafrollers
IQAGAKA Leptoglossus bugs
IRAWAAA Mealybugs
IOBMABA Mexican fruit fly
ITBUALA Orange tortrix
ILAVAAA Spider mites
Issued: 3—07—84 111—053201—48
—150—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Grapes (continued)
Pest list continued from previous page.
IMOAAAA Thrips
IOBMACA West Indian fruit
fly
IRABAAA Whiteflies
Honeydew Melon See Cantaloupe cluster.
/ 14008EA Horseradish (Roots ) 30 ppm
Postharvest commodity fumigation
through 3 pounds per 1,000 cubic
feet.
ENASGGA Imported crucifer 3 lb/l,000 Postharvest commodity fumigation.
weevil cu.ft Expose for 4 hours.
(98%, 100%
PrGs)
Kumquat See Grapefruit cluster.
Lemon See Grapefruit cluster.
Lime See Grapefruit cluster.
Macadamia Nut (Bushnut ) See Almond cluster.
Muskme lons See Cantaloupe cluster.
/05003EA Nectarine 20 ppm
Postharvest commodity fumigation
through 5 pounds per 1,000 cubic
feet.
Refer to Apple cluster.
/28062EA Oats 50 ppm
/28072EA Rice Stored commodity fumigation through
128071EA 6 pounds per 1,000 cubic feet.
/28065EA Wheat
ENATANA Khapra beetle 6 Ib/l,000 Stored coimnodity fumigation. Expose
cu.ft for 12 hours. Use in accordance
(100% PrGs) with the plant quarantine program of
the United States Department of
Agriculture.
Issued: 3—07—84 111—053201—49
—151—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest an Tolerance, Use, Limitations
Formulation(s)
Oats cluster (continued)
VKGAAA.A Rodents (including 0.25 lb/l,000 Stored commodity fumigation. Expose
house mouse, cu .ft for 16 to 24 hours.
Norway rat and (99%, 100%
roof rat) PrGs)
IMAAAFA Stored product 3 lb/1.,000 Stored commodity fumigation. Expose
insects cu.ft for 12 to 24 hours.
(98%, 99%,
99.5%,
99.652,
99.75%,
99.82, 1002
PrGa)
/15015EA Okra 30 ppm
Postharvest commodity fumigation
through 3.5 pounds per 1,000 cubic
feet.
ITBCCFA Armyworm 3.5 lb/1,000 Postharvest commodity fumigation.
INBGAAA Blister beetles cu,ft For pink boliworin , use in accordance
1TB CSA Cabbage looper (98%, 100% with the plant quarantine program of
INAMACA Cucumber beetles PrGs) the United States Department of
IMDAAAA Earwigs Agriculture. Expose for 2 hours.
IQAQACA Green stink bug
INBPAZA Japanese beetle
IQAMARA Lygus bugs
IRAWAAA Mealybugs
IR.ACAOA Melon aphid
ITAMA OA Pink bolluorm
I IFAAEA Sowbugs
ILAVAAA Spider mites
IQAQAAA Stink bugs
IJDAAAA Symphylans
/I4O1 IEA Onion 20 ppm
Postharvest coiodity fumigation
through 3 pounds per 1,000 cubic
feet.
ITBCCFA Armyworm 3 1b/l,000 Poatharvest commodity fumigation.
INBGAAA Blister beetles cu.ft Expose for 6 hours.
ITBCCSA Cabbage looper (98%, 100%
INAMACA Cucumber beetles PrGa)
T14DAAA.A Earwigs
rNBPAZA Japanese beetle
EQAMARA Lygus bugs
LRAWAAA Mea lybugs
Issued: 3—07—84 111 —053201—50
—152—
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EPkCompendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation( a)
Onion (continued)
Pest list continued from previous page.
IOACA Ck Onion maggot
INOCAVA Onion thrips
ILAVAAA Spider mites
IQAQAAA Stink bugs
IJDAAAA Symphylans
/ 14OIIEA Onion (Cipollini Bulbs ) 50 ppm (cippolini bulbs)
Postharvest co=odity fumigation
through 4 pounds per 1,000 cubic
feet.
INAMFBA Exosoma lusi— 4 lb/l000 Postharvest commodity fumigation.
tanicum cu.ft Expose for 4 hours.
(98%, 100%
PrGs)
Orange See Grapefruit cluster.
/140 12EA Parsnip (Roots ) 30 ppm (parsnip root)
/14019EA Turnip (Roots ) (turnip root)
Postharvest coimnodity fumigation
through 3 pounds per 1,000 cubic
feet.
ITBCCFA Armyworm 3 lb/l,000 Postharvest commodity fumigation.
INBGAAA Blister beetles cu.ft Expose for 4 hours.
ITBCCSA Cabbage looper (98%, 100%
IOACADA Cabbage maggot PrGs)
IOBBABA Carrot rust fly
ITBCBOA Corn earworm
INAM CA Cucumber beetles
INBUAAA Darkling beetles
IQAQACA Green stink bug
INBPAZA Japanese beetle
IQAMARA Lygus bugs
IRAWAAA Mealybugs
INAPAFA Mexican bean beetle
IIFAAEA Sowbugs
ILAVAAA Spider mites
IQAQA.AA Stink bugs
IJDAAAA Sytnphylans
Issued: 3—07—84 111—053201—51
—153—
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EPA Compendium of Acceptable Uses
METhYL BROMIDE
Site and Pest !. .! and Tolerance, Use, Limitations
Formulation(s )
/050 04EA Peach 20 ppm
Postharvest commodity fumigation
through 5 pounds per 1,000 cubic
feet 0
Refer to Apple cluster.
Peanuts See Almond cluster.
Pear See Apple cluster.
/28074EA Peas 50 ppm (peas and blackeyed peas)
Stored coodity fumigation through
4 pounds per 1,000 cubic feet.
ITBCCFA Armyworm 3 lb/l,000 Postharvest commodity fumigation.
INAM RA Bean leaf beetle cu.ft Expose for 2 hours.
ITB CSA Cabbage looper (98%, 100%
INANCFA Colorado potato PrGs)
beetle
IRBCBOA Corn earworm
INAGAGA Cowpea weevil
£NAM CA Cucuther beetles
INBUAAA Darkling beetles
INDAAAA Earwigs
IQAQACA Green stink bug
INBPAZA Japanese beetle
ETAAAOA Loopers (including
cabbage looper)
IQAMARA Lygus bugs
ERAWAAA Mealybugs
INAPAFA Mexican bean beetle
IMOCAVA Onion thrips
ILAVA.AA Spider mites
IQAQAAA Stink bugs
IJDAAAA Symphylans
/15007EA (Peas, Dry)
ITBMALA Almond moth 3 lb/1.000 Stored commodity fumigation. Expose
INAGAGA Cowpea weevil cu.ft for 12 hours.
(100% PrGs)
ITBMCHA Indianmeal moth 2 lb/l,000
cu • ft
(100% PrGs)
EMAAAFA Stored product 4 lb/1,000 Stored commodity fumigation. Expose
insects cu .ft for 24 hours 0
(98%, 100%
PrGs)
Issued: 3—07-84 111—053201—52
—134—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Forinulation( s)
Pecan See Almond cluster.
/28O17EA Peppers 30 ppm
/ 1 IOO4EA Pimento Postharvest commodity fumigation
through 4 pound8 per 1,000 cubic
feet.
ITBCCFA Armyworm 4 lb/l,000 Postharvest commodity fumigation.
INBGAAA Blister beetles cu.ft Expose for 2 hours.
IT8 CSA Cabbage looper (98Z, lOOZ
tNAZICFA Colorado potato PrCs)
beetle
LTBCBOA Corn earworm
tNAMACA Cucumber beetles
(including Dia—
brotica beetles)
INBUAAA Darkling beetles
IMDAAAA E arwi gs
ITBMCCA European corn borer
tNBPAZA Japanese beetle
ITAAAOA Loopers (including
cabbage looper)
IQAMARA Lygus bugs
tRAWAAA Mealybugs
IRACAOA Melon aphid
IOBMATA Pepper maggot
IIFAAEA Sowbugs
tLAVAAA Spider mites
IQAQAAA Stink bugs
IJDAAAA Sytuphylans
/06013EA Pineapple 20 ppm
Postharvest commodity fumigation
through 2 pounds per 1,000 cubic
feet.
INBPAZA Japanese beetle 2 lb/l,000 Postharvest commodity fumigation.
IRAWAAA Mealybugs cu.ft Expose for 4 hours.
tOBMA FA Oriental fruit fly (l0O PrGs)
tLAVAAA Spider mites
Pistachio See Almond cluster.
105005EA PLum 20 ppm
Postharvest commodity fumigation
through 5 pounds per 1,000 cubic
feet.
Refer to Apple cluster.
Issued: 3—07—84 111—053201—53
—155—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Tolerance, Use, Limitations
Formulation(s )
/ 140 13EA Potato 75 ppm
/ 140 18EA Sweet Potato Postharvest commodity fumigation
/ 14021EA through 3 pounds per 1,000 cubic
feet
ITBCCFA Armyworm 3 lb/l,000 Postharvest commodity fumigation.
INBCAAA Blister beetles cu .ft Expose potato for 6 hours and sweet
INAMCPA Colorado potato (98%, 100% potato for 4 hours.
beetle PrCs)
ITBCBOA Corn earworm
INAMACA Cucumber beetles
(including Dia—
brotica beetles)
INBUAA.A Darkling beetles
IMDAAAA Earwigs
IQALAHA False chinch bug
INBPAZA Japanese beetle
ITAAAOA Loopers (including
cabbage looper)
IQAMARA Lygus bugs
IRAWAAA Mealybugs
IMOC A VA Onion thrips
tRAXAHA Potato psyllid
IIFAAEA Sowbugs
ILAVAAA Spider mites
IQAQAAA Stink bugs
tJDAAAA Symphylans
/05006EA Prune 20 ppm (plums, fresh prunes)
Postharvest coixmiodity fumigation
through 2 pounds per 1,000 cubic
feet.
IMAAAFA Stored product 5 lb/l,000 Postharvest commodity fumigation.
insects cu.ft Expose for 2 hours.
(98%, 100%
PrGs)
Pumpkin See Cantaloupe cluster.
Quince See Apple cluster 0
Issued: 3- 07-84 IiI- O5320l—54
—156—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Fortnulation( s )
/140 14EA Radish 30 ppm
/ 14015EA Rutabaga Postharvest coodity fumigation
through 3 pounds per 1,000 cubic
feet.
ITBCCFA Armyworin 3 lb/l,000 Postharvest coimnodity fumigation.
ENBGAAA Blister beetles cu.ft Expose radish for 4 hours and ruta
I OACADA Cabbage maggot (98%, 100% baga for 6 hours.
ITBCBOA Corn earworm PrGs)
INAM CA Cucuither beetles
INBUAAA Darkling beetles
IMDAAAA Earwigs
IQALAHA False chinch bug
INBPAZA Japanese beetle
ITAAAOA Loopers (including
cabbage looper)
IRAWAAA Mealybugs
tI!AAEA Sowbugs
ILAVAAA Spider mites
IQAQA.AA Stink bugs
IJDAAAA SymphylaxLs
Rice See Oats cluster.
See Oats cluster.
/ 140 16EA Salsify (Roots ) 30 ppm
Postharvest coimnodity fumigation
through 3 pounds per 1,000 cubic
feet.
ITBCCPA Armyworm 3 lb/1,000 Postharvest commodity fumigation.
INAMADA Flea beetles cu.ft Expose for 4 hours.
IRAFAAA Leafhoppers (98%, 100%
IQAQAAA Stink bugs PrCs)
IQAMATA Tarnished plant bug
128O19EA Sorghum 50 ppm
Stored counnodity fumigation through
6 pounds per 1,000 cubic feet.
INATANA hapra beetle 6 lb/l,000 Stored cotmnodity fumigation.
cu.ft Expose for 12 hours. Use in accord—
(100% PrGs) ance with the plant quarantine pro-
gram of the United States Department
of Agriculture.
Issued: 3—07—84 111—053201—55
—157—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
VKGAAAA
Sorghum (continued)
Rodents (including
house mouse,
Norway rat and
roof rat)
0.25 Lb/l,000
cu. ft
(99%, 100%
PrGs)
Stored commodity fumigation.
for 16 to 24 hours.
Expose
IMAAAFA
Stored product
insects
4 lb/1,000
cu. ft
(98%, 99%,
99,5%,
99.65%,
99.75%,
99.8%, 100%
PrGs)
Stored commodity fumigation.
for 12 to 24 hours.
Expose
5—6 ].b/l,000
Cu. ft
(100% PrGs)
Stored commodity fumigation.
for 12 hours.
Expose
/IOOI3EA
/ IOOI4EA
Squash (Suiinner)
Squash (Winter )
20 ppm (winter squash)
30 ppm (Summer squash)
Postharvest commodity fumigation
through 4 pounds per 1,000 cubic
feet 0
Armywo rm
Blister beetles
Cucu!ther beetles
(including Dia—
brotica beetles)
Darkling beetles
False chinch bug
Japanese beetle
Loopers (including
cabbage looper)
Lygus bugs
Melon aphid
Pick leworm
S owbugs
Spider mites
Squash bug
Squash vine borer
Stink bugs
Syiuphylans
4 lb/1,000
Cu. ft
(98%, 100%
PrGa)
Issued: 3—07—84
111 —053201—56
—158 -
Postharvest commodity fumigation.
Expose for 2 hours.
1TBCC A
INBGAAA
INAMACA
INBUAAA
IQALARA
INBPAZA
ITAAAOA
IQAMARA
IRA CAD A
ITBMAWA
IIFAAEA
ILAVAAA
IQAGAFA
ITBQADA
IQAQAAA
IJDAAAA
-------
EPA Compendium of Acceptable Uses
METBYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s )
/IOOI5EA Squash (Zucchini ) 20 ppm
Postharvest commodity fumigation.
Expose for 3 hours.
ITBCC!A Armyworin 2.5 lbIl.,000 Postharvest commodity fumigation.
INBGAAA Blister beetles cu.ft Expose for 3 hours.
INAM CA Cucun er beetles (98%, 100%
(including Dia— PrGs)
brotica beetles)
INBUAAA Darkling beetles
IQALAHA False chinch bug
INBPAZA Japanese beetle
ITAAAOA Loopers (including
cabbage looper)
IQAMARA Lygus bugs
IRACADA Melon aphid
ITBMAWA Pickleworm
I IFAAEA Sowbugs
ILAVAAA Spider mites
IQAGAFA Squash bug
ITBQADA Squash vine borer
IQAQAAA Stink bugs
IJDAAAA Symphylans
Sugar Beets See Beets (Roots) cluster.
Sweet Potato See Potato cluster.
Tangelo See Grapefruit cluster.
Tangerine See Grapefruit cluster.
/26003EA Tobacco N.F.
Postharvest commodity fumigation
through 4 pounds per 1,000 cubic
feet.
V DAAAA Bats 0.25 lb/1,000 Stored co=odity fumigation. Expose
VKCCAAA Moles cu.ft for 6 hours.
V GAAAA Rodents (98% PrGs)
INABADA Cigarette beetle 2—3 lb/l,000 Stored coimnodity fumigation. Apply
tNABAEA Drugstore beetle cu.ft by atmospheric fumigation. Expose
ITBMBLA Tobacco moth (98%, 99%, for 48 to 72 hours.
99. 5%,
99.65%,
99.75%,
99.8%, 100%
PrGs)
Issued: 3—07—84 111—053201—57
—159—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest
Tobacco (continued)
sand
Tormulation( s )
4 lb/l,000
Cu 0 ft
(98%, 99%,
99.5%,
99.65%,
99075%,
99.8%, 100%
PrGs)
Tolerance, Use, Limitations
Stored coimnodity fumigation. Apply
by vacuum chamber fumigation. Ex-
pose for 4 hours with a sustained
vacuum of 25 to 27 inches (equiva-
lent to a barometric pressure of 3
to 5 inches mercury).
IMAAAFA
Stored product
insects
2.25—4.5 lbI
1,000 cu.ft
[ less than
100,000
cu .ft]
or
1.5—2.25 lb/
1,000 cu.ft
(100,000—
500,000
cu.ftl
or
1.5—1.875 lb/
1,000 cu,ft
(500,000—
1,000,000
cu. ft]
or
1.5 lb/1,000
cu. ft
[ over
1,000,000
cu.ftj
(98%, 100%
PrGa)
Stored co=odity fumigation in ware
houses. Decrease the dosage by 33
percent when treating unbaled tobac-
co. Expose for 24 hours.
Tomato
Turnips
Walnut
See Eggplant cluster.
See Parsnips cluster.
See Almond cluster.
Watermelons
Wheat
See Cantaloupe cluster.
See Oats cluster.
Issued: 3—07—84
111—053201—58
—160—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s )
/ 14021EA Yams 30 ppm
Postharvest commodity fumigation
through 3.5 pounds per 1,000 cubic
feet.
Refer to Potato cluster for use and limitation
information.
( Processed or Manufactured Products, and Food or Feed Containers or
Dispensers
/46013EA Airtight Chambers (Empty) (includ-
ing Atmospheric Chambers, Vacuum
Chambers and Fumigation Vaults )
VKGAAAA Rodents (including 0.25 lb/1,000 Fumigation of airtight chambers.
house mouse, cu.ft Expose for 12 to 24 hours.
Norway rat and (100% PrGs)
roof rat)
IMAAAFA Stored product 1—3 lb/l,000 Fumigation of airtight chambers.
insects cu.ft Expose for 3 hours.
(98%, 100%
PrGs)
I 44006EA Burlap Bags (Empty )
ITBMCHA tndianmeal moth 3—4 lb/l,000 Fumigation of empty burlap bags.
INBEAFA Lyctus beetles cu.ft Expose for 24 hours.
LNAAACA Powderpost beetles (100% PrGs)
143046EA Candy (Processed ) 125 ppm (processed food)
Stored commodity fumigation through
2 pounds per 1,000 cubic feet.
ITBMCHA Indianmeal moth 1—2 lb/l,000 Stored commodity fumigation. Expose
INARAGA Sawtoothed grain cu.ft for 12 to 24 hours. Allow 24 hours
beetle (100% PrGs) for aeration.
/43002EA Cereals (Processed ) 125 ppm (processed food)
Stored coiodity fumigation through
2 pounds per 1,000 cubic feet.
INAAAFA Stored product 1—2 lb/1,000 Stored commodity fumigation. Expose
insects cu .ft for 12 to 24 hours. Allow 24 hours
(100% PrGs) for aeration.
Issued: 3—07—84 111—053201—59
—161—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s )
/43049EA Cheese, Cheese Byproducts 325 ppm (parmesan and rouquefort
cheese)
Stored commodity fumigation through
2 pounds per 1,000 cubic feet.
ITABAFA Cheese mite 1—2 lb/l,000 Stored commodity fumigation. Expose
IOAZABA Cheese skipper cu.ft for 12 to 24 hours.
IMA.AAFA Stored product (98%, 100%
insects PrGs)
/43024EA Copra 100 ppm
Stored commodity fumigation through
2.5 pounds per 1,000 cubic feet 0
LMAAAFA Stored product 2.5 lb/l,000 Stored commodity fumigation. Expose
insects cu.ft for 24 hours.
(98%, 100%
PrGs)
/43039EA g Feed 400 ppm
Stored commodity fumigation through
2 pounds per 1,000 cubic feet.
ENABADA Cigarette beetle l 2 lbfl,000 Stored coumiodity fumigation. Expose
!TBMCRA Indianmeal moth cu.ft for 12 to 24 hours. Allow 8 hours
(100% ?rGs) for aeration.
/43023EA Eggs (Dried ) 400 ppm
Stored commodity fumigation through
2 pounds per 1,000 cubic feet.
INATAKA Larder beetle 1—2 lb/l,000 Stored commodity fumigation. Expose
cu.ft for 12 to 24 hours.
(100% PrGa)
/46034 Feed/Food Containers (Empty) (in-
cluding Bags, Boxes and Crates )
VKGAAAA Rodents (including 0.25—0.31 lb/ Fumigation of feed/food containers.
mice and rats) 1,000 cu.ft Expose for 12 to 18 hours.
(98%, 99%,
99.5%,
99.75%,
100% PrGs)
Issued: 3—07—84 tII O5320l—60
—162—
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EPA Compendium of Acceptable Uses
METIF!L BROMIDE
Site and Pest and Tolerance, Use, Limitations
Forinulation( s)
Feed/Food Containers (Empty) (including Bags, Boxes and Crates
(continued)
II4AAAFA Stored product 1.5—3 lb/ Fumigation of feed/food containers.
insects l,000/cu.ft Apply by atmospheric fumigation.
(98%, 99%, Expose for 24 hours.
99. 5%,
99.65%,
99.75Z,
99.8%, 100%
PrGa)
2—3 lb/1,000 Fumigation of feed/food containers.
cu.ft Apply by vacuum chamber fumigation.
(98%, 99%, Expose for 2 hours.
99.5%,
99.65%,
99.75%,
99.8%, 100%
PrGa)
/4301 1EA Flour (including Bagged Cereal 125 ppm (processed food)
Flour, Bakery Mixes and Cereal Stored connnodity fumigation through
Flour ) 2 pounds per 1,000 cubic feet.
IMAAAFA Stored product 1—2 lb/1,000 Stored cotodity fumigation. Expose
insects cu.ft for 12 to 24 hours.
(98%, 100%
PrGs)
/43026EA Fruits (Dried) (including Apple , 125 ppm (processed food)
Apricot, Cherry, Date, Fig, Peach, , 250 ppm (dried figs)
Pear, Prune and Raisin ) Stored coimuodity fumigation through
1.5 pounds per 1,000 cubic feet.
IMAAAFA Stored product 1—1.5 lb/ Stored coumiodity fumigation.
insects 1,000 cu.ft Expose for 12 to 24 hours.
(98%, 100%
PrGa)
Issued: 3—07—84 111—053201—61
—163—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest and Tolerance, Use, Limitations
Formulation(s )
/46015EA Cram Bins (Empty )
VKGAAAA Rodents (including 4—5 oz/l,000 Fumigation of empty grain bins. Ex—
mice and rats) cu.ft pose for 12 to 18 hours.
(98%, 99%,
99. 5%,
99,75%,
99.8%,
100% PrGs)
IMAAAPA Stored product 1.5—3 lb/ Fumigation of empty grain bins. Ex ’
insects 1,000 cu.ft pose for 24 hours 0
(less than
100,000
cu. ft I
or
1.25—1.5 lb/
1,000 cu.ft
(100,000—
500,000
cu. ftl
or
1—1.25 lbI
1,000 cu 0 ft
(500,000—
l, 000 i 000
cu.ft]
or
1 lb/l,000
cu. ft
(over
1,000,000
cu.ft]
(98%, 99%,
9905%,
99.65%,
99.75%,
99.8%, 100%
PrGa)
/43046EA Grain Products (Processed ) 125 ppm (processed food)
Stored commodity fumigation through
2 pounds per 1,000 cubic feet.
IM&AAFA Stored product 1—2 lb/],000 Stored counnodity fumigation of pro—
insects cu.ft cessed grain to be used in produc—
(100% PrCs) tion of fermented beverage. Expose
for 12 to 24 hours.
Issued: 3—07—84 111—053201—62
—164—
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EPA Compendium of Acceptable Uses
! THYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s )
/43008EA Herbs, Seasoning or Spices (Dried ) 400 ppm (processed herbs and spices)
Stored coodity fumigation through
3 pounds per 1,000 cubic feet.
VKCAAAA Rodents 0.25 lb/l,000 Stored commodity fumigation. Expose
cu.ft for 12 to 18 hours.
(100% PrCa)
INAAAFA Stored product 3 lb/1,000 Stored commodity fumigation. Expose
insects cu.ft for 12 to 24 hours.
(98%, 100%
PrGs)
/43047EA Meat Products (including Cured Meat 125 ppm (processed food)
Products ) Stored conunodity fumigation through
2 pounds per 1,000 cubic feet.
Labeling claims for meat products
include cured ham, bacon and sau-
sage.
VKCAAAA Rodents 0.2.5 lb/1,000 Stored coimnodity fumigation. Expose
cu.ft for 12 to 18 hours.
(100% PrGa)
ThA AAFA S’t or’ed p oduct. 2 thft,000 Stored commedity fumigation. cpose
insects cu.ft for 12 to 24 hours.
(100% PrGs)
/46035EA Nonfeed/Nonfood Containers (Empty)
( including Bags, Boxes and Crates )
INAAAFA Stored product 11 lb/l,000 Fumigation of empty nonfeed/nonfood
insects cu.ft containers. Expose for 24 hours.
(98% PrGs)
/44O 1OEA Paper (Stored )
VXDAAAA Bats 0.25 lb/1,000 Stored commodity fumigation. Expose
VKCCAAA Moles cu.ft for 12 to 18 hours.
!KCAAAA Rodents (98% PrGs)
Issued: 3—07—84 111—053201—63
—165—
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EPA Compendit.&m of Acceptable Uses
METHYL BROMIDE
Site and Pest and Tolerance, Use, Limitations
Formulation(s)
(Stored ) (continued)
IMAAAPA Stored product 2.25—4.5 lb/ Stored commodity fumigation in ware—
insects 1,000 cu.ft houses. Expose for 24 hours.
(less than
1,000 cu.ftl
or
1.875—2.25
lb/l,000
cu.ft
(100, 000—
500,000
cu ft1
or
1.5—1.875 lb/
1,000 cu.ft
(500,000—
1,000,000
cu. ft I
or
1.5 lb/1,000
Cu. ft
(over
1,000,000
cw.ftl
(98% PrGs)
/43027EA Processed Foods 125 ppm
Stored commodity fumigation through
2 pounds per 1,000 cu.ft.
IMA.AAFA Stored product 1—2 lb/1,000 Stored commodity fumigation. Expose
insects cu .ft for 12 to 24 hours.
(100% PrCs)
/44006EA Tarpaulins
VKGAAAA Rodents (including 4 oz/1,000 Fumigation of tarpaulins. Expose
house mouse, cu.ft for 12 to 18 hours.
Norway rat and (100% PrGs)
roof rat)
IMAMFA Stored product 145 lb/l,000 Fumigation of tarpaulins. Expose
insects cu.ft for 24 hours 0
(100% PrOs)
Issued: 3—07—84 1 11—053201—64
—166—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest
Dosages and
àrmulation( s )
Tolerance, Use, Limitations
( Agricultural Premises and Equipment )
Ants
Bed bug
Carpenter ants
Carpet beetle
Clothes moth
Cockroaches
Deathwatch beetle
family
Lyctus beetles
Millipedes
Oldhouse borer
Powderpoat beetles
Silverfish
Spiders
Termites (including
dauipvood and dry—
wood termites)
Fumigation of barns. Apply the low-
er dosage for barns in good condi-
tion and the higher dosage for barns
in unfavorable condition. Expose
for 12 to 24 hours.
V GAAAA
Rodents (including
mice and rats)
0.25—0.31 lb/
1,000 cu.ft
(98%, 99%,
99.75%, 100%
PrGs)
Fumigation of barns.
to 18 hours.
Expose for 12
IMAAAFA
Stored product
insects
1.5—3 lb/
1,000 cu.ft
(less than
100,000
cu. ft
or
1.25—1.5 lb/
1,000 cu.ft
(100,000—
500,000
cu. ft]
or
1—1.25 lb/
1,000 cu.ft
(500,000—
1,000,000
cu. ft]
(99.65%,
99.8%, 100%
PrGs)
or
Fumigation of barns.
hours.
Expose for 24
111—05 3 201—65
—167—
/61009EA Barns
1—3.75 1b/
1,000 cu.ft
(98%, 99%,
99.5%,
99.75%, 100%
PrGs)
ISASAAA
I QAFACA
ISASAFA
INATAFA
IT BSA BA
IVAAA BA
INABAAA
INBEAFA
IJCAAAA
INALANA
INAAACA
IMP BACA
IKAAAAA
IMGAAAA
Issued: 3—07—84
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Barns (continued)
I lb/l,000
cii. ft
(over
1,000,000
cu.ft]
(99. 65%,
99.8%, 100%
PrGs)
/61012EA Farm Storage Areas
IMA.AAFA Stored product 3 lb/l,000 Fumigation of farm storage areas.
insects cu.ft Expose for 24 hours.
(98% PrGs)
/61006EA Greenhouses (Empty )
tNATANA Khapra beetle 5 lb/l,000 Fumigation of empty greenhouses.
cu.ft Use in accordance with the plant
(98% PrGs) quarantine program of the United
States Department of Agriculture.
Expose for 48 hours.
tRAWAAA Mealybugs 3 lb/l,000 Fumigation of empty greenhouses.
ELAAABA Mites cu.ft Expose for 4 hours.
ERAAABA Scales (98%, 99%,
99.5%,
99.65%,
99.75%,
99.8%, 100%
PrGs)
/61007EA Mushroom Houses (Empty )
EOAVABA Mushroom flies 2 lb/1,000 Fumigation of empty mushroom houses.
tNAAAFA Stored product cu.ft Expose for 24 hours.
insects (98%, 99%,
99.5%,
99.65%,
99.75%,
99.8%, 100%
PrGs)
VKGAAAA Rodents 0.25 lb/l,000 Fumigation of empty mushroom houses.
cu.ft Expose for 12 to 18 hours.
(100% PrGs)
Issued: 3—07- 84 111—053201—66
—168—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
/ 55000EA
Poultry Houses (Empty )
Bed bug
Poultry mite
( Household )
2 lb/l,000
cu.ft
(98%, 99%,
99.5%,
99.65%,
99.75%,
99.8%, 100%
PrGs)
General Warnings and Limitations : Fwnigation of domestic dwellings is
limited to professional pest control operators. Do not use formulations
containing more than 2 percent ch].oropicrin for household sites.
/63007EA Domestic Dwelling Contents (includ-
ing Furniture )
Bed bug
Carpenter ants
Carpet beetle
Cigarette beetle
Clothes moth
Cockroaches
Deathwatch beetle
family
Drugstore beetle
Powderpost beetles
Silverfish
Termites (including
dampwood and dry—
wood termites)
Fumigation of domestic dwelling con-
tents. Apply by atmospheric fumiga-
tion. Expose for 24 hours.
Fumigation of domestic dwelling con-
tents. Apply by vacuum chamber.
Expose for 2 hours with a sustained
vacuum of 25 to 27 inches (equiva-
lent to a barometric pressure of 3
to 5 inches mercury).
/63000EA
ISASAAA
IQAFACA
I SASAFA
INATAFA
IT BSA BA
IVAAA BA
INABAAA
ENBEAFA
EJCAAAA
INALANA
Ants
Bed bug
Carpenter ants
Carpet beetle
Clothes moth
Cockroaches
Deathwatch beetle
family
Lyctus beetles
Millipedes
Oldhouse borer
Issued: 3—07—84
1—3.75 lb/
1,000 cu.ft
(98%, 99%,
99.5%,
99.75%, 100%
PrGs)
111—053201—67
—169—
EQAPACA
ILAHABA
Fumigation of empty poultry houses.
Expose for 24 hours.
IQAFACA
I SASAFA
INATAFA
INABADA
IT BSA BA
IVAAA BA
INABAAA
INABAEA
INAAACA
IMPBACA
LNGAAAA
1—3 lb/l,000
cu. ft
(98%, 99%,
99.65%,
99.75%,
99.8%, 100%
PrGs)
2—3 lbfl,000
Cu. ft
(98%, 99%,
99 • 65%,
99.75%,
99.8%, 100%
PrGs)
Domestic Dwellings (including
Garages )
Fumigation of domestic dwellings.
Apply by structural fumigation. Ap-
ply the lower dosage for dwellings
in good condition and the higher
dosage for dwellings in unfavorable
condition. Expose for 12 to 24
hours.
-------
EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Domestic Dwellings (including Garages ) (continued)
Pest list continued from previous page.
INA.AACA Powderpost beetles
IMPBACA Silverfish
IKAAAAA Spiders
EMGAAAA Termites (including
dampwood and dry—
wood termites)
VKGAAAA Rodents (including 0.25—0.31 lb/ Fumigation of domestic dwellings.
mice and rats) 1,000 cu.ft Expose for 12 to 18 hours.
(98%, 99%,
99.7 5X,
100Z PrGs)
IMAAAFA Stored product 1.5—3 lb/ Fumigation of domestic dwellings.
insects 1,000 cu.ft Expose for 24 hours.
[ less than
100,000
cu. ftj
or
1.25—1.5 lb/
1,000 cu.ft
[ 100,000—
500,000
cu.ft]
or
1—1.25 lb/
1,000 cu.ft
(500, 000—
1,000,000
CU. ftl
or
I lb/l,000
CU. ft
[ over
1,000,000
cu. ft]
(99.65%,
99.8%, 100%
PrGa)
Issued: 3—07—84 111—053201—68
—170—
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EPA Compendium of Acceptable Uses
METWYL BROMIDE
Site and Pest
Dosages and
rmu1ation( s )
Tolerance, Use, Limitations
( Wood or Wood Structure Protection Treatment )
/6400 1EA
IMAAAKA
Lumber and Wood Products
Wood destroying
insects
I—) lb/l,000
Cu. ft
(98%, 99%
99.5%,
99.65%,
99.75%,
99.8%, 100%
PrGs)
Fumigation of lumber and wood pro-
ducts. Apply by atmospheric fuiniga—
tion. Expose for 24. hours.
2—3 lb/1,000
Cu. ft
(98%, 99%
99.65%,
99.75%,
99.8%, 100%
PrGs)
( Con ercial and Industrial Uses )
Fumigation of lumber and wood pro-
ducts. Apply by vacuum chamber.
Expose for 2 hours with a sustained
vacuum of 25 to 27 inches (equiva-
lent to a barometric pressure of 3
to 5 inches mercury).
VKGAAAA
INARAGA
Rodents (including
house mouse,
Norway rat and
roof rat)
Sawtoothed grain
beetle
3.5—4.5 lb/
1,000 cu.ft
(100% PrGs)
0.25 lbIl,000
Cu. ft
(100% PrGs)
3—3.75 lb/
1,000 cu.ft
(100% PrCs)
Fumigation of empty boxcars/railway
cars of wood composition. Expose
for 16 to 24 hours. Allow 4 hours
for aeration.
Fumigation of empty boxcars/railway
cars. Expose for 12 to 18 hours.
Fumigation of empty boxcars/railway
cars of steel composition. Expose
for 16 to 24 hours. Allow 4 hours
for aeration.
IMA.AAFA
Stored product
insects
2 lb/1,000
Cu. ft
[ steel box-
car in good
condition]
(100% PrCs)
or
Fumigation of empty boxcar/railway
cars. Expose for 12 to 18 hours.
Issued: 3—07—84
111—053201—69
/70005EA Boxcars/Railway Cars (Empty )
IN AAAE A
IT BMCHA
Branbugs
Indianmeal moth
—171—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Tolerance, Use, Limitations
Formulation(s)
Boxcars/Railway Cars (Empty ) (continued)
2.5 ].b/l,000
cu.ft
(steel box-
car in fair
cond it ion]
or
2.5 lb/l,000
cu. ft
[ wood boxcar
•in good con—
dit ion]
or
3 lb/l,000
Cu. ft
[ wood boxcar
in fair con-
dition]
(100% PrGs)
or
10—15 lb/box-
car
(98%, 1.00%
PxGe)
/71000EA Food Processing, Handling and
Storage Areas Specific sites under this general
grouping include: bakeries, cereal
plants, coffee warehouses, grain
storage buildings, meat storage
buildings, milling plants, packaging
plants and port warehouses.
VKDAAAA Bats 0.25—0.31 lb/ Fumigation of food processing, hand—
V (CCAAA Moles 1,000 cu.ft ling and storage areas. Expose for
VKGAAAA Rodents (including (982, 99%, 1.2 to 18 hours.
house mouse, 99.5%, 99.8%
Norway rat and 100% PrGs)
roof rat)
Issued: 3—07—84 111—053201—70
—172—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Food Processing, Handling and Storage Areas (continued)
ENAAAFA Stored product 1.5—3 lb/ Fumigation of food processing hand—
insects 1,000 cu.ft ling and storage areas. Expose for
(less than 12 to 24 hours.
100,000
cu. ft]
or
1.25—1.5 lb/
1,000 cu.ft
(100,000—
500,000
cu.ft]
or
1—1.25 lbI
1,000 cu.ft
(500,000—
1,000,000
cu.ft]
or
1 lb/1,000
cu. ft
[ over
1,000,000
cu.ft]
(98%, 99%,
99. 5%
99.652,
99.8%, 100%
PrGs)
/71008EA Meat Processing Plants (including
Ham Houses )
IOAZABA Cheese skipper 1—2 lb/l,000 Fumigation of meat processing
INATAKA Larder beetle cu.f plants. Expose for 12 to 24 hours.
ILAAABA Mites (98%, 100%
ENAOADA Redlegged ham PrGs)
beetle
/70004EA Ships (Cargo)/Steel Barges
V1CGAAAA Rodents (including 0.25 lb/l,000 Fumigation of cargo ships and steel
house mouse, cu.ft barges. Expose for 12 to 18 hours.
Norway rat and (100% PrGs)
roof rat)
Issued: 3—07—84 111—053201—71
—173—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Ships (Cargo)/Steel Barges (continued)
IMAAAFA Stored product 1—2 lb/1,000 Fumigation of cargo ships and steel
insects cu.ft barges. Expose for 12 to 24 hours.
(98%, 100%
PrGa)
/70006EA Trailers (Emp yj
/70003EA Van Containers (Empty )
VKGAAAA Rodents (including 0.25 lb/l,000 Fumigation of empty trailers and van
house mouse, cu.ft containers. Expose for 12 to 18
Norway rat and (100% PrCs) hours.
roof rat)
IMAAAFA Stored product 1—3 lb/1,000 Fumigation of empty trailers and van
insects cu.ft containers. Apply the lower dosage
(100% PrGs) for trailers and van containers in
good condition and the higher dosage
for trailers and van containers in
fair condition. Expose for 12 to
24 hours.
Issued: 3—07—84 111—053201—72
—174—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
tisting of Registered Pesticide Products by Formulation
&099.9901 100% technical chemical
methyl bromide (053201)
003377—00009 005785—00051 015298_00004*
*jacket currently unavailable for review
&067.0002 67% formulation intermediate
methyl bromide (053201)
005785—00052 005785—00056
&233.0018 33% pressurized gas
methyl bromide (053201) plus chloropicrin (081501)
005785—00025
&243.0018 43% pressurized gas
methyl bromide (053201) plus chloropicrin (081501)
000550—001l6#
#suspended
&245.00l8 45% pressurized gas
methyl bromide (053201) plus chloropicrin (081501)
005785—00023 008536—00006 011220—00011
&250.0018 50% pressurized gas
methyl bromide (053201) plus chioropicrin (081501)
000550—00128# 005785—00048 008536—00009 011220—00010
#suspended
&257.00 18 57% pressurized gas
methyl bromide (053201) plus chioropicrin (081501)
000550—00 129# 005785—00028 008536—00007 011220—00004
#suspended
&266.O018 66% pressurized gas
methyl bromide (053201) plus chloropicrin (081501)
003377—00017 009782—00053 014775—00020
&267.0018 67% pressurized gas
methyl bromide (053201) plus chioropicrin (081501)
000550—00117# 003442—00699 005549—00068 005785—00024
008536—00005 008622—00011 008622—00013 008853—00003
011220—00007
#suspended
&267.0018 67% (9.51 lb/gal) pressurized gas
methyl bromide (053201) plus chloropicrin (081501)
005785—00045 037733—00006
Issued: 3—07—84 111—053201—73
—175—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Listing of Registered Pesticide Products by Formulation (continued)
6268.6018 68.6% pressurized gas
methyl bromide (053201) plus chloropicrin (081501)
000876—00260 001598—00159 001598—00224 002124—00499
003442—00680 003743—00182 003743—00337 004185—00351
005549—00050 005 797—00103 008622—00001 0086 22—00009
008622—00014 008853—00001 009859—00222 014775—00002
042463—00028
&268.6018 68.6% (8.23 lb/gal) pressurized gas
methyl bromide (053201) plus chloropicrin (081501)
005785—00013
6270.0018 70% pressurized gas
methyl bromide (053201) plus chlorinated C3 hydrocarbons (029001 and
029002)
008536—00010
methyl bromide (053201) plus chloropicri i (081501)
005785—00019 005785—00026
&275.0018 75% pressurized gas
methyl bromide (053201) plus chloropicrin (081501)
005785—00040 008536—00001 008536—00011 008622—00015
011220—00006 011220-00008
6280.0018 80% pressurized gas
methyl bromide (053201) plus chioropicrin (081501)
005785—00047 011220—00003
&288.2018 88.2% pressurized gas
methyl bromide (053201) plus chioropicrin (081501)
014775—00008
&288.2018 88.2% (12 lb/gal) pressurized gas
methyl bromide (053201) plus chloropicrin (081501)
005785—00061
&298.0018 98% pressurized gas
methyl bromide (053201) plus chioropicrirt (081501)
000264—00360 000481—00078 000550—00 123# 000876—00256
003377—00007 003377—00016 003377—00018 005549—00073
005785—00004 005785—00022 005785—00042 006720—00230
008622—00006 008622—00010 008622—00012 008853—00002
009782—00056 009859—00227 014775—00019 019713_00088*
045115—00030
suspended
*jacket currently unavailable for review
&298.0018 98% (14.11 lb/gal) pressurized gas
methyL bromide (053201) plus chloropicrin (081501)
037 733—00005
Issued: 3—07—84 111—053201—74
—176—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Listing of Registered Pesticide Products by Formulation (continued)
&299.0018 99% pressurized gas
methyl bromide (053201) plus chloropicrin (081501)
000876—00258 005785—00007
&299.5018 99.5% pressurized gas
methyl bromide (053201) plus chioropicrin (081501)
000550—00 1311fr 005785—00008 008536_00012* 011220—00009
suspended
*jacket currently unavailable for review
&299.6518 99.65% pressurized gas
methyl bromide (053201) plus chloropicrin (081501)
008622—00017
&299.7518 99. 75% pressurized gas
methyl bromide (053201) plus chioropicrin (081501)
003377—00016 005785—00055
&299.8018 99.8% pressurized gas
methyl bromide (053201) plus chloropicrin (081501)
0086 22—00016
&299.9918 100% pressurized gas
methyl bromide (053201)
000485—00048 000550—00130 - 000876—00257 003377—00008
003377—00015 005785—00011 005785—00041 008536—00015
008622—00005 036301—00006#
#suspended
&299.9918 100% (14.4 lb/gal) pressurized gas
methyl bromide (053201)
037733—00007
&299.9918 100% (14.5 lb/gal) pressurized gas
methyl bromide (053201)
005785—000 21
Issued: 3—07—84 111—053201—75
—177—
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EPA Compendium of Acceptable Uses
METHYL BROMIDE
Listing of Registered Pesticide Products by Formulation (continued)
9999999 State Label Registrations
AZ Reg. No.
005785—03682 005785-03683
CA Reg. No.
000550—04772 000550—04781 000550—07428 005481—03842
005481—03843 005481-03844 005481—03862 005785—03684
005785—03685 0O5785 03686 005785—03689 005785—03691
005785—03693 005785—03695 008536—05611 008536—05612
008536—05613 008536—05616 008536—06020 010965—10035
011019—09360 011101—08248 011174—08190 011198—03734
011220—05370 011220—05371 011220—05581 011220—05627
011220—05629 011220-05630 011220—05631 011220—05632
011231—03718 034485—06991
FL Reg. No.
000829—06760 000829—06761 000829—06762 003122—07560
003122—07561 003122—07562 003122—07563 003122—07564
003442—03254 005785—03681 009782—03631 015091—10542
111 Reg. No.
000550—07429 037843—08538 037843—08545 037843—08546
037843—08547 03781i3—08548 037843—08549 037843—08566
MI Reg. No.
005785—03680
NV Reg. No.
037855—08290
WA Reg. No.
005785—03675 005785—03676
Issued: 3—07—84 111—053201—76
—178—
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GUIDE TO USE OF THIS BIBLIOGRAPHY
1. CONTENT OF BIBLIOGRAPHY. This bibliography contains
citations of all studies considered relevant by EPA in
arriving at the positions and conclusions stated elsewhere
in the Standard. Primary sources for studies in this
bibliography have been the body of data submitted to EPA
and its predecessor agencies in support of past regulatory
decisions. Selections from other sources including the
published literature, in those instances where they have
been considered, will be included.
2. UNITS OF ENTRY. The unit of entry in this bibliography
is called a “study.” In the case of published materials,
this corresponds closely to an article. In the case of
unpublished materials submitted to the Agency, the Agency
has sought to identify documents at a level parallel to
the published article from within the typically larger
volumes in which they were submitted. The resulting
“studies” generally have a distinct title (or at least a
single subject), can stand alone for purposes of review,
and can be described with a conventional bibliographic
citation. The Agency has attempted also to unite basic
documents and commentaries upon them, treating them as a
single study.
3. IDENTIFICATION OF ENTRIES. The entries in this bibliography
are sorted numerically by “Master Record Identifier,” or
MRID, number. This number is unique to the citation, and
should be used at any time specific reference is required.
It is riot related to the six—digit “Accession Number’
which has been used to identify volumes of submitted
studies; see paragraph 4(d)(4) below for a further explana-
tion. In a few cases, entries added to the bibliography
late in the review may be preceded by a nine—character
temporary identifier. These entries are listed after
all MRID entries. This temporary identifier number is
also to be used whenever specific reference is needed.
4. FORM OF ENTRY. In addition to the Master Record Identifier
(MRID), each entry consists of a citation containing
standard elements followed, in the case of material
submitted to EPA, by a description of the earliest known
submission. Bibliographic conventions used reflect the
standards of the American National Standards Institute
(ANSI), expanded to provide for certain special needs.
—179—
-------
a. Author. Whenever the Agency could confidently identify
one, the Agency has chosen to show a personal author.
When no individual was identified, the Agency has
shown an identifiable laboratory or testing facility
as author. As a last resort, the Agency has shown
the first submitter as author.
b. Document Date. When the date appears as four digits
with no question marks, the Agency took it directly
from the document. When a four—digit date is followed
by a question mark, the bibliographer deduced the
date. from evidence in the document. When the date
appears as (19??), the Agency was unable to determine
or estimate the date of the document.
c. Title. In some cases, it has been necessary for
Agency bibliographers to create or enhance a document
title. Any such editorial insertions are contained
between square brackets.
d. Trailing Parentheses. For studies submitted to the
Agency in the past, the trailing parentheses include
(in addition to any self—explanatory text) the fol-
lowing elements describing the earliest known submission:
(1) Submission Date. The date of the earliest known
submission appears immediately following the word
r e ce i v e d.•
(2) Administrative Number. The next element,
immediately following the word “under,” is the
registration number, experimental use permit
number, petition number, or other administrative
number associated with the e -irliest known submission.
(3) Submitter. The third element is the submitter,
following the phrase “submitted by.” When
authorship is defaulted to the submitter, this
element is omitted.
(4) Volume Identification (Accession Numbers). The
final element in the trailing parentheses
identifies the EPA accession number of the volume
in which the original submission of the study
appears. The six—digit accession number follows
the symbol “CDL,” standing for “Company Data
Library.” This accession number is in turn
followed by an alphabetic suffix which shows the
relative position of the study within the volume.
For example, within accession number 123456, the
first study would be 123456—A; the second, 123456—
B; the 26th, 123456—Z; and the 27th, 123456—AA.
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OFFICE OF PESTICIDE PROCRAI4S
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Methyl Bromide Standard
MRID CITATION
00012908 Dow Chemical Company (1962) Determination of Inorganic Bromide Res-
idue in Pineapple Resulting from Soil Fumigations with Bro—
zone, Trizone or Dowfume W—85. (Unpublished
study received Jul 5, 1962 under 5F0426; CDL:090462—K)
00012999 Dow Chemical Company (1960) A Study of Bromide Residues in Straw-
berries from Preplant Soil Fumigation with Methyl bromide. (Un-
published study received Apr 28, 1961. under 464—223; CDL:
119921—A)
00013000 Dow Chemical Company (1961) Bromide Residues in Tomatoes from Pre—
plant Soil Fumigations with Brozone. (Unpublished study
received Apr 28, 1961 under 464—223; CDL: 119921—B)
00013057 Gregory, R.L. (1964) Determination of Propargyl bromide and Total
Bromide Residues in Strawberries, Muskmelons, Tomatoes, Broc-
coli, Eggplant, Cauliflower, and Peppers Grown on Soil Fumi.gated
with Trizone or Propargyl bromide. (Unpublished study re-
ceived Sep 4, 1964 under unknown admin. no.; submitted by Dow
Chemical U.S.A., Midland, Mich.; CDL:131472—J)
00026180 Shrader, S.A.; Beshgetoor, A.W.; Stenger, V.A. (1942) Determination
of total and inorganic Bromide in foods fumigated with Methyl
bromide. Industrial and Engineering Chemistry 14(1):1—4. (Also
in unpublished submission received Nov 11, 1966 under 464—240;
submitted by Dow Chemical U.S.A., Midland, Mich.; CDL:003480—F)
00043601 Getzendaner, M.E. (1961) Experimental fumigations with Methyl bro-
mide. Cereal Science Today 6(8):268—270. (Also in unpubl!shed
submission received Nov 11, 1966 under 464—240; submitted by
Dow Chemical U.S.A., Midland, Mich.; CDL:003480—H)
00065237 Bridges, R.G. (1955) The fate of labelled insecticide residues in
food products. III.——N—Methylation as a result of fumigating
wheat with Methyl bromide. Journal of the Science of Food and
Agriculture 6(5):261—268. (Reprint; also in unpublished submis-
sion received Jun 7, 1976 under 464—3; submitted by Dow Chemical
U.S.A., Midland, Mich.; CDL:227158—M)
00066267 Bistline, F.W. (1970) Letter sent to A.E. Witison dated Jul 27,
1970: Status report of tree response from methyl—bromide soil
injections. (Unpublished study received Jan 11, 1972 under 464—
104; prepared by Coca—Cola Co., submitted by Dow Chemical
U.S.A., Midland, Mich.; CDL:003405—D)
—181—
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Methyl Bromide Standard
MRID CITATION
00077846 Stoner, H.C. (1970) Lester sent to Deryl Bondshu dated Dec 9,
1970: Results of analyses on sunflower seeds, treated and un-
treated with methyl bromide. (Unpublished study received Dec
19, 1972 under 3E1346; prepared by Stoner Laboratories, Inc.,
submitted by California, Dept. of Agriculture, Sacramento,
Calif.; CDL:093603—B)
00079041 Abdalla, N.A.; Lear, B. (1975) Determination of inorganic bromide
in soils and plant tissues with a bromide selective—ion elec-
trode. Communications in Soil Science and Plant Analysis 6(5):
489—494. (Also in unpublished submission received Jul 21, 1981
under 1E2541; submitted by Interregional Research Project No. 4,
New Brunswick, N.J.; CDL:070192—C)
00079042 Lear, B. (1979) Residue Determinations——Methyl Bromide on Onins.
(Unpublished study, including letter dated Apr 24, 1979 from
H.G. Alford to Richard T. Guest, received Jul 21, [ 981 under
1E2541; prepared by Univ. of California—Davis, Dept. of
Plant Pathology, submitted by interregional Research Project
No. 4, New Brunswick, N.J.; CDL:070192—D)
00079043 Ferguson, M.P. (1980) Letter sent to Drew M. Baker dated Mar 14,
1980 Dates of treatment, planting and harvesting of methyl bro-
mide on onions. (Unpublished study received Jul 21, 1981 under
1E2541; submitted by Interreglonal Research Project No. 4, New
Brunswick, N.J.; CDL:070192—E)
00079048 Dow Chemical U.S.A. (1980) Residues of Methyl Bromide in Asparagus
and Lettuce. (Compilation; unpublished study receIved Jul
21, 1981 under 464—303; CDL:070203—B)
00079550 Winteringham, F.P.W.; Harrison, A.; Bridges, R.G.; et al. (1955)
The fate of labelled insecticide residues in food products. II——
The nature of methyl bromide residues in fumigated wheat. Jour-
nal of the Science of Food and Agriculture 6(May):251—261. (Al-
so in unpublished submission received Jun 7, 1976 under 464—3;
submitted by Dow Chemical U.S.A., Midland, Mich.; CDL:227157—F)
00088683 Dow Chemical Company (1954) The Residues of Bromides Resulting
from the Fumigation with Methyl Bromide. (Unpublished study
received May 1, 1955 under PPOOI4; CDL:090090—Q)
00089066 Dow Chemical Company (1955) Residues: Methyl Bromide. (Unpub-
lished study received on unknown date under PP0055; CDL:
090053—A)
—182—
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OFFICE OF PESTICIDE PROGRAMS
REG [ STRATtON STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Methyl Bromide Standard
MRID CITATION
00089457 Dow Chemical Company (1957) Analyses——Bromide Residues. (Unpub-
lished study received on unknown date under PP0175; CDL:
090203—A)
00090147 Sco, S.T.; Balock, J.W. (1961) Total Bromides in Asparagus Fumi-
gated with Methyl Bromide: Special Report Ho—31. (U.S. Agri-
cultural Research Service, Entomology Research Div., Fruit and
Vegetable Insects Research Branch, Hawaii Fruit Fly trivestiga—
tions; unpublished study; CDL:090381—A)
00090266 Dow Chemical Company (1962) Bromide Residues in Eggs and Chicken
Tissues from Feed Fumigated with Methyl Bromide. (Unpublished
study received Sep 30, 1963 under PP0345; CDL:090374—B)
00090269 Pauling, L.E.; Mejeur, W.H. (1963) A Study of Bromide Residue in
Milled Fractions of Various Commodities Fumigated with Methyl
Bromide. (Unpublished study received Sep 30, 1963 under PP0345;
prepared by Michigan Chemical Corp., submitted by Dow Chemical
Co., Indianapolois, md.; CDL:090374—E)
00090270 Shuinan Chemical Laboratory, Incorporated (1963) Feeding Methyl
Bromide Fumigated Corn to Beef Cattle and Swine: Report No. 44.
(Unpublished study received Sep 30, 1963 under PP0345; submitted
by Dow Chemical Co., Indianapolis, Irid.; CDL:090374—G)
00090271 Getzendaner, M.E. (1963) A Study of Bromide Residues in Chicken
Tissues and Eggs from Ingestion of Methyl Bromide Fumigated
Feed. (Unpublished study received Sep 30, 1963 under PP0345;
submitted by Dow Chemical Co., Indianapolis, tnd.; CDL:090374—I)
00090408 U.S. Agricultural Research Service, Plant Quarantine Division
(1964) Report on the Determination of Inorganic Bromides in
Products Fumigated with Methyl Bromide. (Unpublished study;
CDL: 090506—B)
00096432 Interregional Research Project Number 4 (1980) Bromide Residues
in Strawberries. Includes method Pr be—64 dated Dec 23, 1965
and method dated Oct 14, 1980. (Compilation; unpublished study,
including published data, received Feb 26, 1982 under 2E2654;
CDL: 070705—A)
00102990 Sikov, M.; Cannon, W.; Carr, D.; et al. (1981) Teratologic Assess-
ment of Butylene Oxide, Styrene Oxide and Methyl Bromide.
Cincinnati, Ohio: U.S. National Institute for Occupational
Safety and Health, Div. of Biomedical and Behavioral Science,
Experimental Toxicology Branch. (Contract no. 210—78—0025;
available from: Superintendent of Documents, U.S. Government
Printing Office, Washington, DC 20402; published study; CDL:
247562—B)
—183—
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Methyl Bromide Standard
MRID CITATION
00109713 Ferguson Fuinigants (1963) Residue of Bromine Residues in Several
Foods. (Compilation; unpublished study received May 17, 1965
under 5H1714; CDL:221617—A)
00112926 Interregional Research Project No. 4 (1979) Analytical Methods Used
and Recovery Data: Bromide. (Compilation; unpublished study
received Aug 8, 1982 under 9E2139; CDL:071083—A)
00118768 Interregional Research Project No. 4 (1973) The Results of Tests on
the Amount of Inorganic Bromide, Organic Bromide and Total Bro-
mide Residues (Calculated as Br.) Remaining in or on Comb Honey
Including a Description of the Analytical Methods Used. (Compi-
lation; unpublished study received Apr 13, 1973 under 3E1387;
CDL: 093700—B)
001 L8817 Dow Chemical Co. (1955) Bromide Residues in Various Crops. (Com-
pilation; unpublished study received on unknown date under
PPOO I4; CDL:094562—A)
00118820 Dow Chemical Co. (19b0) Bromide Residues in Popcorn Resulting from
Methyl Bromide Fumigations. (Unpublished study received Jun 7,
1976 under PP0251; CDL:096408—B)
00118821 Interregional Research Project No. 4 (1977) The Results of Tests on
the Amount of Inorganic Bromide Residues Remaining in or on Al-
mond Hulls, Nutmeats, and Shells, Including a Description of the
Analytical Method Used. (Compilation; unpublished study re—
00118823 Seo, S.; Balock, J.; Burditt, A. (1959) Bromide Residues in Avaca—
do, Bell Pepper, and Tomato Fumigated with Methyl Bromide: Spe-
cial Report Ho—28. (Unpublished study received on unknown date
under PP0175; prepared by U.S. Agricultural Research Service,
Entomology Research Div., Subtropical Fruit Insects Section,
submitted by Dow Chemical Co., Indianapolis, IN; CDL:098160—A)
00118825 Chevron Chemical Co. (1973) Bromide Residues in Milk, Grain, Hay,
and Strawberries. (Compilation; unpublished study received on
unknown date under 0F0975; CDL:098499—A)
00118829 Harris, T.; Thomas, R.; Peters, A. (1963) Methyl Bromide Residues
In Grapes. (Compilation; unpublished study received on unknown
date under unknown admin. no.; submitted by ?; CDL: 124597—A)
—184—
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Methyl Bromide Standard
MRID CITATION
00118830 Hayward, J. (1966) Methy Bromide: Residues in Alfalfa and Other
Subjects. (Compilation; unpublished study received Aug 8,
1966 under unknown admin. no.; submitted by ?; CDL: 124608—A)
00118831 Barthel, W.; Wainerdi, R. (1966) Bromide: Residues in Hay and
Other Subjects. (Compilation; unpublished study received Jan
19, 1966 under unknown admin. no.; submitted by ?; CDL: 124609—A)
00118837 Barnes, D.; Stagg, S.; Mayer, E.; et al. (1959) Methyl Brotnide:
Residues in Raisins and Other Crops. (Compilation; unpublished
study received Feb 26, 1960 under 0H0116; submitted by ?; CDL:
221569—B)
00118838 Shrader, S.; Beshgetoor, A.; Stenger, V. (1960) Determination of
Residues of Methyl Bromide in Various Products. (Compilation;
unpublished study received Mar 8, 1961 under 0H0435; submitted
by ?; CDL:221585—A)
00118845 Dow Chemical U.S.A. (1975) Methyl Bromide Analytical Residue
Report——Strawberries. (Compilation; unpublished study received
Mar 2, 1976 under 464—3; CDL:230666—8)
00119256 Dow Chemical Co. (1957) The Results of Tests on the Amount of
Residue Remaining: Bromides. (Compilation; unpublished study
received on unknown date under PPO IO3; CDL:090133—E)
00119550 U.S. Agricultural Research Service, Pesticide Regulations Div. Lab-
oratory (1965) Report on the Determination of Inorganic Bro-
mides in Various Products Fumigated with Methyl Bromide. (lJn—
published study received Oct 8, 1965 under unknown admin. no.;
submitted by ?; CDL: 124610—A)
00125059 Lynn, G. (1956) Letter sent to F. Vorhes dated Sep 20, 1956 Bro—
m.ide residues. (Unpublished study received 1956 under PP0055;
submitted by Dow Chemical U.S.A., Midland, MI; CDL:092336—A)
00127221 Ford, J.; Mitchell, W.; Grubbs, J.; et al. (1942?) Bromide Residues
following Fumigation of Soybeans with Methyl Bromide. (Unpub-
lished study received Oct 14, 1964 under 5F0428; submitted by
U.S. Agricultural Research Service, Plant Pest Control Div.,
Denver, CO; CDL:092716—A)
00127767 Interregional Research Project No. 4 (1982) The Results of Tests
on the Amount of Methyl Bromide Residues Remaining in or on
Blueberries, Including a Description of the Analytical Method
Used. (Compilation; unpublished study received Mar 14, 1983
under 464—3; CDL:071457—A)
—185—
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Methyl Bromide Standard
MRID CITATION
00135683 Seo, S.; Balock, J.; Burditt, A. (1952?) Bromide Residues in Avoca-
do, Bell Pepper and Tomato Fumigated with Methyl Bromide: Spe-
cial Report HO—28. (Unpublished study received Dec 26, 1961 un-
der PP0341; prepared by Subtropical Fruit Insects Section, sub-
mitted by U.S. Dept. of Agriculture, Entomology Research Div.,
Tifton, GA; CDL:092624—A)
00140445 U.S. Agricultural Research Service (1961) Residue: Bromide on
Apples and Others. (Compilation; unpublished study received
May 3, 1.961 under PP0326; CDL:092608—A)
00147718 Craine, E. (1985) A Hydrolysis Study with Methyl Bromide: Project
WIL—49003. Unpublished study prepared by WIL Research Laborato-
ries, Inc. 47 p.
00149535 Ethyl Corp. (1984) [ Residue Data for Methyl Bromide]. Unpublished
compilation. 269 p.
00152907 Great Lakes Chemical Corp. (1984) [ Analysis of Methyl Bromide Res-
idues in Fruits and Vegetablesj. Unpublished compilation. 57 p.
00153317 Methyl Bromide Industry Panel (1985) The Results of Tests on the
Amount of Organic Methyl Bromide Residues Remaining in or on
Various Fumigated Commodities and a Description of the Analyt-
ical Methods Used. Unpublished compilation. 600 p.
00157445 US Dept. of Agriculture (1970) BromIde Residues in Vegetable
Samples. Unpublished compilation prepared by Agricultural Res-
earch Service. 5 p.
00159648 Reeves, R. (1981) Monitoring Methyl Bromide Levels in Pier Ware-
houses at the Port of Oakland, California, and Observing the
Process of Fumigation of Imported Items under Quarantine,
October 1980: Report No. HS—904. Unpublished study prepared by
California Dept. of Food and Agriculture. 2 p.
00159649 Maddy, K.; Lowe, J.; Gibbons, D. et al. (1986) Studies of Methyl
Bromide and Chloropicrin Used as Structural Fumigants in Cal-
ifornia, 1984: I. Evaluation of Chloropicrin as A Warning Agent:
II. Employee Exposure to Methyl Bromide and Chioropicrin:
III. Penetration of Methyl Bromide into Plastic Food Storage
Bags: Report No. HS—1352. Unpublished study prepared by
California Dept. of Food and Agriculture. 50 p.
00159651 Cusick, W.; Reeves, R.; Conrad, D,; et al. (1981) Monitoring Methyl
Bromide Levels around an Almond Warehouse during Futnigation(...)
Report No. lLS—902. Unpublished study prepared by California
Department of Food and Agriculture. 3 p.
—186—
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Methyl Bromide Standard
MRID CITATION
00159652 Maddy, K.; Richmond, D.; Lowe, J. (1982) A Study of the Inhalation
Exposure of Workers to Methyl Bromide during Preplant Soil
Fumigations (Shallow Injection)(...); Report No. HS—900. Unpub-
lished study prepared by California Dept. of Food and Agricul-
ture. 9 p.
00159653 Maddy, K.; Gibbons, D.; Richmond, D.; et al. (1983) A Study of the
Levels of Methyl Bromide and Chioropicrin in the Air Downwind
from a Field during and after a Preplant Soil Fumigation (Shal-
low Injection) — A Preliminary Report: HS—1061. Unpublished
study prepared by California Dept. of Food & Agriculture. 14 p.
00159654 Maddy, K.; Gibbons, D.; Richmond, D.; et al. (1984) A Study of the
Inhalation Exposure of Workers to Methyl Bromide and Chloropi
cnn during Preplant Soil Fumigations (Shallow Injection) in
1982 —— A Preliminary Report: HS—1076. Unpublished study pre-
pared by CaLifornia Dept. of Food & Agriculture. 12 p.
00159655 Maddy, K.; Schneider, F.; Lowe, J.; et al. (1983) Monitoring Envi-
ronmental Levels of Methyl Bromide during Commodity Fumigations;
HS—1078. Unpublished study prepared by California Dept. of
Food & Agriculture. 8 p.
00159656 Maddy, K.; Jacobs, K.; Fredericksort, S. (1983) A Srudy of tnhala—
tion Exposures of Tarpaulin Fumigation Workers to Methyl Bromide
in Merced County, California in November 1982: US—1084. Unpub-
lished study prepared by California Dept. of Food & Agriculture.
6 p.
00159657 Maddy, K.; Fredrickson, S.; Jacobs, K. (1983) Inhalation Exposure
of Tarpaulin Fumigation Workers to Methyl Bromide in Kern Coun-
ty, Calfornia in November 1982: HS—1092. Unpublished study pre-
pared by California Dept. of Food & Agriculture. 6 p.
00159658 Maddy, K.; Lowe, J.; Fredrickson, S. (1984) Inhalation Exposure of
Commodity Handlers to Methyl Bromide in Yolo County, California,
October 1983: HS—1168. Unpublished study prepared by California
Dept. of Food & Agriculture. 8 p.
00159659 Maddy, K.; Gibbons, D.; Richmond, D.; et al. (1984) Additional
Monitoring of the Inhalation Exposure of Workers to Methyl Bro-
mide and Chloropicrth during Preplant Soil Fumigations (Shallow
Injection) in 1983: HS—1175. Unpublished study prepared by Ca-
lifornia Dept. of Food & Agriculture. 11 p.
—187—
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OFFICE OF PESTICIDE N(OCRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Methyl Bromide Standard
MRID CITATION
00159660 ?laddy, K.; Gibbons, D.; Richmond, D.; et al. (1984) Additional
Monitoring of the Concentrations of Methyl Bromide and Chioro—
picrin in the Air Downwind from Fields during and after Preplant
Soil Fumigations (Shallow Injection): HS—1183. Unpublished
study prepared by California Dept. of Food & Agriculture. 18 p.
00159661 Maddy, K.; Lowe, J.; Fredrickson, S. (1984) Employee Exposure to
Methyl Bromide Used for Ground Squirrel Control: HS—1238. Un-
published study prepared by California Dept. of Food and Agri-
culture. 13 p.
00159662 Vaughan—Dellarco, V.; Fowle III, J.; Rosenthal, S. (1985) Assess-
ment of the Mutagenic Potential of Carbon Disulfide, Carbon
Tetrachioride, Dichioromethane, Ethylene Dich [ oride, and Methyl
Bromide: A Comparative Analysis in Relation to Ethylene Dibro
mide: Report No. EPA/600/6—85/0O1. Unpublished study prepared
by US Environmental Protection Agency. 152 p.
00159664 Opresko, D.; Daugherty, M. (1985?) Chemical Hazard Information Pro-
file: Methyl Bromide: Draft Report: 74—83—9. Unpublished study
prepared by Oak Ridge National Laboratory. 72 p.
00160627 De Vries, J.W.; Broge, J.M. et. al. (1985) Headspace Gas Chromato—
graphic Method for Determination of Methyl Bromide in Food In-
gredients. J. Assoc. Off. Anal. Chem. 68(6): [ 112—1116.
00160628 Reeves, R.G.; McDaniel, C.A. et. al. (1985) Organic and Inorganic
Bromide Residues in Spices Fumigated With Methyl Bromide. J.
Agric. Food Chem. 33(5): 780—783.
00160629 Tebbets, J.S.; Hartsell, P.L. et. al. (1983) Methyl Bromide Fumi-
gation of Tree Fruits for Control of the Mediterranean Fruit
Fly. J. Agric. Food Chem. 31(2): 247—249.
—188—
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0MB ApprovalN. .i. 2’) ‘.468
FIFRA SECTION 3(C)(2)(B) SUMMARY SHEET
EPA REGISTRATION NO
PRODUCT NAME
APPLICANT’S NAME
DATE GUIDANCE DOCUMENT
With respeCt to the requirement to submit “generic” data imposed by the FIFRA section 3(C)(2)(B) notice contained in the referenced
Guidance Document, I am responding in the following manner:
0 1. I will submit date in a timely manner to estisfy the following requirements. If the test procedures I will use deviate from (or are not
specified In) the Registration Guidelines or the Protocols contained in the Reports of Export Groups to the Chemicals Group, OECD
Chemicals Testing Programme, I enclose the protocols that I will use:
02. I have entered Into an agreement with one or more other registrants under FIFRA section 3(C)(2)(B)(ii) to setigfy the following data
requirements. The tests, and any required protocols, wilt be submitted to EPA by:
-
NAME OF OTHER REGISTRANT
03. I enclose a completed “Certification of Attempt to Enter Into an Agreement with Other Registrants for Development of Date” with
respect to the following date requirements: -
04. I request that you emend my registration by deleting the following uses (this option is not available to applicants for new products):
0 5. I request voluntary cancellation of the registration of this product. (This option is not available to applicants for new products.)
REGISTRANT’S AUTHORIZED REPRESENTATIVE SIGNATURE DATE
EPA Form 8580-1 (10-82)
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0MB Annrnval No 2000-0468
CERTIFICATION OF ATTEMPT TO ENTER
INTO AN AGREEMENT WITH OTHER REGISTRANTS
(To quality, ce tity Jj four items) FOR DEVELOPMENT OF DATA
GUIDANCE DOCUMENT DATE
1. I am duly authorized to represent the following firm(s) who are subject to the require-
ments of a Notice under FIFRA Section 3(c)(2) (B) contained In a Guidance Document
to submit data Concerning the active ingredient:
ACTIVE INGREDIENT
EPA COMPANY NUMBER
NAME OF FIRM
Tlhis firm or group of firms is referred to below as “my firm”. )
2. My firm is willing to develop and submit the data as required by that Notice, if necessary. However, my firm would prefer to c i
into an agreement with one or more other registrants to develop jointly, or to share in the cost of developing, the following requ
items or data:
3. My firm has offered in writing to enter into such an agreement. Copies of the offers are attached. That otter was irrevocable and included an offer U e
bound by an arbitration decision under FIFRA Section 3(c)(2)(B)(iii) if final agreement on all terms could not be reached otherwise. This offer was m e
to the following firm(s) on the following date(s):
NAME OF FIRM
i wever , none of those firm(s) accepted my offer.
4. My firm requests that EPA not suspend the registration(s) of my firm’s product(s), if any of the firms named in paragraph (3) abo
have agreed to submit the data listed in paragraph (2) above in accordance with the Notice. I understand EPA will promptly inforrr
me whether my firm must submit data to avoid suspension of its registration(s) under FIFRA Section 3(c)(2)(B). (This statement
does not apply to applicants for new products.) I give EPA permission to disclose this statement upon request.
TYPED NAME I
I
I
a
-------
PRODUCT SPECIFIC DATA REPORT
EPA Reg. No.____________________________ Date ________
Guidance Document for
Registration
Guideline No.
Name of Test
Test not
required
for my
product
listed
above
(check
below)
I am complying with
data requirements by
(For EPA Use Only)
Accession Numbers
Assigned
Citing MRID
Number or
EPA Accession
Number
Submit—
ting
Data
(At—
tached)
§158. 120
PRODUCT
CHEMISTRY
61—1
Identity of
ingredients
61—2
Statement of
composition
61—3
Discussion of
formation of
ingredients
62—1
Preliminary
analysis
62—2
CertificatIon of
limits
62—3
Analytical methods
for enforcement
limits
-
63—2
Color
63—3
Physical state
63—4
Odor
63—5
Melting point
63—6
Boiling point
63—7
Density, bulk—
density, or
specific_gravity
63—8
Solubility
63—9
Vapor pressure
63—10
Dissociation
constant
63—11
Octanol/water
partition
coefficient
63—12
pH
—191—
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Registration
Guideline No.
Name of Test
Test not
required
for my
product
listed
above
(check
below)
I am complying with
data requirements by
(For EPA Use Only)
Accession Numbers
Assigned
Citing MRID
Number or
EPA AcLesslon
Number
Submit—
ting
Data
(At—
tached)
63—13
Stability
63—14
Oxidizing/reducing
reaction
.
63—15
Flammability
63—16
Explodability
63—17
Storage stability
63—18
Viscosity
63—19
Miscibility
63—20
Corrosion
characteristics
63—21
Dielectric break-
down_voltage
§158.135
TOXICOLOGY
81—1
Acute oral
toxicity,_rat
81—2
Acute dermal
toxicity,_rabbit
81—3
Acute inhalation,
toxicity,_rat
81—4
Primary eye
irritation, rabbit
81—5
Primary dermal
irritation
81—6
Dermal sensitiza—
t ion
—192—
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EOPULI L’OR 1 S EX 4PTION STAT ENT
(40 CFR 152.85)
EPA File S mtol/Reg. No. ______________ Product Name
Applicant’s Name and Address _____________________
As an authorized representative of the applicant for registration of the
product identified above, t hereby certify that:
(1) This product àontains the active ingredient(s): _____________
(2) Each active ingredient listed in paragraph (1) is present solely
as the result of the incorporation into the product (during formulation or
packaging) of another product which contaiiis that active ingredient, which
is registered under FIFRA sec. 3, and which is purchased bsr us raii another
producer.
(3) Indicate by circling (A) or (B) below which paragraph applies:
(A) An accurate Confidential Statement of Formula (EPA Form 8570—4) for
the above identified product is attached to this . tatement. That formula
statement indicates, by canpany name, registration number and product
name, the source of the active ingredient(s) listed in paragraph (1).
OR
(B) The Confidential Statement of Formula dated _________ on file with
the EPA is ca ip].ete, current and accurate and contains the information
required on the current F Form No. 8570—4. The req istered source(s)
of the active ingredient(s) listed in paragraph (1) is/are listed below:
active ingredient Source: Product name and Req. No.
Signature ________
r)ate ________________ Title ________
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