&EPA
United States
Environmental Protection
Agency
OSWER (5204-G)
ORD (RD-689)
OERR 9200.6-3-3 (93-1)
NTISNO. PB93-92119
EPA 540-R-93-058
July 1993
Superfund
Health Effects Assessment Summary
Tables
Supplement No. 1 to the
March 1993 Annual Update
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9200.6-303 (93-1)
EPA 540-R-93-058
PB93-921199
July 1993
HEALTH EFFECTS ASSESSMENT
SUMMARY TABLES
FY-1993 Supplement No. 1
Office of Research and Development
Office of Emergency and Remedial Response
U.S. Environmental Protection Agency
Washington, DC 20460
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DISCLAIMER
This report has been prepared by the U.S. Environmental
Protection Agency. The information contained herein has been taken
from final documents prepared by the Office of Health and Environ-
mental Assessment for the Office of Solid Waste and Emergency
Response and the Office of Water, Washington, DC and the Office of
Air Quality Planning and Standards, Research Triangle Park, NC.
These documents were reviewed in accordance with Agency policy and
approved for publication. Mention of trade names or commercial
products does not constitute endorsement or recommendation for use.
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TABLE OF CONTENTS
Page
INTRODUCTION 1
WHAT’S NEW IN ThE JULY 1993 SUPPLEMENT NO. 1 9
HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) 1-1
HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) 2-1
HEAST TABLE 3: CARCINOGENICITY 3-1
REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC
TOXICITY (OTHER THAN CARCINOGENICITY) Ri-i
REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -
SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) R2-i
REFERENCES FOR HEAST TABLE 3: CARCINOGENICITY R3-1
111
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INTRODUCTION
This document is the July 1993 Supplement No. 1 for the March
1993 Annual Update of the Health Effects Assessment Summary Tables
(HEAST) prepared by EPA’s Office of Health and Environmental
Assessment, Environmental Criteria and Assessment Office,
Cincinnati, OH for use at both Superfund and RCRA sites. It
updates the information in the March 1993 HEAST and should be
checked whenever that document is consulted. This supplement was
not produced to stand alone and does not contain the User’s Guides
or Appendix that are available in the annual update. Thus, the
user is strongly encouraged to reference the March 1993 HEAST for
this information. Supplement No. 2 for the March 1993 HEAST is
)lanned for release in November 1993.
The HEAST is a comprehensive listing consisting almost
entirely of PROVISIONAL HEALTH EFFECTS INFORMATION relative to oral
and inhalation routes for chemicals of interest to Superfund, the
Resource Conservation and Recovery Act (RCRA), and the EPA in
general. These entries in the HEAST are limited to chemicals that
have undergone review and have the concurrence of individual Agency
Program Offices, and each is supported by an Agency reference.
This health effects information has not, however, had enough review
to be recognized as high quality, Agency-wide consensus
information.
The Integrated Risk Information System (IRIS) is the Agency’s
official repository of Agency-wide consensus chronic human health
risk information. IRIS evaluations are conducted by the Agency’s
Work Group Review process, i.e., they have been examined by either
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the Reference Dose/Reference Concentration (RfD/RfC) Work Group or
the Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work
Group. These Agency Work Groups conduct a process that leads to
internal Agency scientific consensus regarding health effects
information on a chemical. This information is recorded on IRIS,
is considered to be “Work Group Verified”, and does not appear on
the HEAST. Thus, provisional health effects information on the
HEAST is subject to possible review and revision by these Agency
Work Groups.
There are two exceptions to the above discussion. The HEAST
also contains information on chemicals that are a part of the
National Ambient Air Quality Standards (NAAQS) or the Drinking
Water Criteria Document (DWCD) series. In each of these cases, the
chemicals are subject to extensive scientific peer review processes
of extremely high quality.
CHEMICAL STATUS DEFINITIONS
Chemicals reviewed by the Agency Work Groups are classified
according to their status as either “verified”, “not verifiable”,
or “under review”. The toxicity values (other than NAAQS or DWCD
values) listed on the HEAST are considered to be “provisional.”
The Agency has no official definitions for these terms, but the
HEAST user may interpret them as follows:
Provisional: A toxicity value or a cancer value is
“provisional” if the value has had some form of Agency
review, but it does not appear on the IRIS system. These
values are generated in several ways. Often they are
determined in the course of developing an Agency document
on a chemical or on a class of chemicals. Some have been
generated through the Work Group process, but have not
yet been input to the IRIS system. At the time each
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value was derived, all available information on the
chemical was evaluated, the value was calculated using
the most current methodology, and a consensus was reached
on the value by Agency scientists.
Brackets are placed around the names of toxicity and
carcinogenicity values on the HEAST to distinguish these
“provisional” values from information on IRIS. The
following names are affected: RfD to [ RfD ], RfC to
[ RfC], slope factor to [ slope factor], EPA group to [ EPA
Group] and unit risk to [ unit risk].
These “provisional” values are found on the HEAST. They
do not appear on IRIS.
Verified: A toxicity value or a cancer value is “Work
Group Verified” if all available information on the value
has been examined by an Agency Work Group, the value has
been calculated using current Work Group methodology, a
unanimous consensus has been reached on the value by the
Work Group, and the value appears on IRIS.
Some numbers that have achieved unanimous consensus by
the Work Group may appear on the HEAST for a short time
until they are loaded onto IRIS, at which time they are
termed, “verified.” During the interim, they are
considered to be “provisional” values that are still
“under review” by the Work Group.
These “verified” numbers only appear on IRIS. They do
not appear on the HEAST.
Not verifiable: A toxicity value is “not verifiable” if
an Agency Work Group has considered all available data on
a chemical and has unanimously determined that data are
inadequate to generate a value that would be suitable for
inclusion on IRIS. No toxicity value is calculated; no
toxicity value is available for IRIS or the HEAST.
This “not verifiable” status is noted on IRIS, and is
sometimes found on the HEAST, with a pointer to the IRIS
system.
Under Review: A toxicity value is “under review” if an
Agency Work Group is in the process of considering all
available data on a chemical. All Work Group chemicals
will have this status until the toxicity value is placed
on the IRIS system. Toxicity values that have been
withdrawn from IRIS by a Work Group for further review
will have this status.
This “under review” status may be indicated on IRIS or on
the HEAST. During this time, “provisional” toxicity
values may appear on the HEAST.
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In all cases, the status of a chemical may change as new data
become available, and the assessment is revisited.
CAUTION
It is imperative for each user of the 1-lEAST to recognize that
the values listed in the toxicity tables and the cancer table are
generally considered to be PROVISIONAL HEALTH EFFECTS INFORMATION.
The user is referred to IRIS for “Work Group Verified” values. It
is also important to remember that the numbers in these tables
alone tell very little about the adverse effects of a chemical or
the quality of evidence on which health effects information is
based. Original assessment documents must be consulted by users of
the HEAST in order to fully appreciate the strengths and limita-
tions of a specific data base. Original source documents will
allow for the most complete characterization of potential toxicity
associated with the range of exposure pathways generally evaluated
at Superfund and RCRA sites. The Reference Tables point the user
to these sources.
CONTRIBUTORS
Chemicals commonly found at RCRA sites as identified by the
Office of Solid Waste’s (OSW) Technical Assessment Branch are
included in the HEAST. The Office of Radiation Programs has
provided data on radionuclide carcinogenicity for Tables 4A and 4B
of the HEAST. Finally, the Office of Air Quality Planning and
Standards (OAQPS) has provided information on chemicals for which
Air Quality Criteria Documents and National Ambient Air Quality
Standards have been developed.
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CHEMICALS LISTED
Most of the chemicals included on the toxicity tables and
carcinogenicity table are those for which at least one of the
following EPA documents has been written: Health Effects Assess-
ment Document (HEA), Health and Environmental Effects Profile
(HEEP), Health and Environmental Effects Document (HEED), Health
Assessment Document (HAD), Air Quality Criteria Document (AQCD),
Drinking Water Criteria Document (DWCD). A description of each is
provided in Appendix A, Section I. In a few cases, the values are
supported by other written material, such as Work Group meeting
notes or Carcinogen Assessment Group (CAG) Profiles. Radionuclide
slope factor values are calculated by the EPA’S Office of Radiation
Programs.
The names of criteria pollutants that are regulated as
National Ambient Air Quality Standards (NAAQS) under the Clean Air
Act are listed in the main body of the HEAST, but the actual
criteria are included as Section V of Appendix A: Technical
Information. The NAAQS were not included in the tables in order to
distinguish them from the reference concentration ( [ RfC]) values.
The NAAQS and [ RfCJs represent different levels of review and
different methods of calculation and thus, must be interpreted and
used differently.
HIERARCHY OF SOURCES
It is recognized that at any point in time there may be
multiple old and new Agency documents or data bases that present
different values on a specific chemical. For chemicals other than
chose represented by the NAAQS or DWCDs, the following hierarchy of
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sources is recommended in evaluating chemical toxicity for
Superfund sites:
1. The Agency’s Integrated Risk Information System
(IRIS) and cited references. Changes are made in
this data base on a monthly basis, but there may be
data gaps. Call IRIS USER SUPPORT at (513)569-7254
for further information.
2. The Health Effects Assessment Summary Tables (HEAST)
and cited references.
3. Consultation with the Superfund Health Risk Tech-
nical Support Center (TSC) at (513)569-7300.
4. Do not consult either the toxicity tables (Appendix
A) in the Superfund Public Health Evaluation Manual
(SPHEM, U.S. EPA, 1986) or the September 1988 Public
Health Risk Evaluation Data Base (PHRED) as these
sources are likely to contain numerous values that
have since become out-of-date.
QUESTIONS
Chemical Toxicity and Carcinogenicity
Regional EPA Superfund Staff may direct questions regarding
the contents of the chemical toxicity and carcinogenicity tables on
the HEAST (e.g., chemicals not covered, chemicals with pending
[ RfD]s) to EPA’s Superfund Health Risk Technical Support Center
(TSC) in Cincinnati, OH at (513)569-7300. Questions from other
users must be submitted to the TSC in writing and must contain the
following information :
• Superfund site name, site location and twelve-digit
site number;
• Name and phone number of the site Remedial Project
Manager (RPM) or Regional Risk Assessor/Toxicologist;
• Detailed description of the health effects information
related question.
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Please send requests via mail or FAX to:
Superfund Health Risk Technical Support Center
US EPA
26 W. ML King Dr.
Environmental Criteria and Assessment Office
MS 117
Cincinnati, OH 45268
FAX#: (513)569-7159
RCRA Chemicals
Questions about RCRA chemicals may be addressed by calling the
Office of Solid Waste at (202)260-4761.
Radionuclide Carcinogenicity
Questions concerning radionuclide carcinogenicity should first
be addressed by contacting the appropriate Regional Radiation
Program Manager. A listing of these managers and several contacts
in the Office of Radiation Programs can be found in Exhibit 2 of
he User’s Guide — Radionuclide Carcinogenicity.
REFERENCES
Most cited Agency references (e.g., HEAs, HEEPs, HEEDs), are
(or will soon be) available through the National Technical
Information Service (NTIS), 5285 Port Royal Road, Springfield, VA
22161 [ (703)487-4650]. Carcinogen Assessment Group (CAG) Profiles
cited in Table 3 are available through the RCRA docket
(202)260-9327.
ORDERING INFORMATION
Limited copies of the HEAST are available for EPA Superfund
staff, State Superfund programs and other Federal agencies working
n Superfund sites, and EPA contractors working for the EPA Super-
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fund program. Users in these groups can call Syracuse Research
Corporation (202)479-0881 to be put on the mailing list.
EPA’s Office of Solid Waste (OSW) requests that their users
(i.e., OSW staff, contractors, State solid waste programs) call the
Health Assessment Section (202)260-4761 to obtain copies of the
HEAST. Regional OSW staff are reminded that copies are sent to all
EPA Regional libraries.
Users of the HEAST in EPA’s Office of Air and Radiation and
State air programs should call Kelly Rimer of E PA’s Office of Air
Quality Planning and Standards at (919)541-2962.
All other users must purchase the document from:
National Technical Information Service (NTIS)
5285 Port Royal Road
Springfield, VA 22161
(703) 487-4650
For ordering information, call the NTIS Subscriptions
Department at (703)487-4630. NTIS normally ships 4th class United
States mail. Therefore, users may wish to consult with NTIS
concerning the use of an overnight delivery service. The NTIS
order number is PB93-92l199.
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WHAT’S NEW IN THE JULY 1993 SUPPLEMENT NO. 1
GENER.MJ CHANGES — CHEMICAL TOXICITY AND CARCINOGENICITY
The changes in this version of the HEAST reflect changes in
IRIS through June 1, 1993. It is also current with RtD/RtC and
CRAVE Work Group activities through May 1, 1993. Cross-references
between tables may refer the user to the March 1993 HEAST Annual
Update for that information.
CHEMICAL-SPECIFIC CHANGES — CHEMICAL TOXICITY AND CARCINOGENICITY
A. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 1: SUBCHRONIC AND
CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
Bromoethene
Added to Table 1. An indicator was added to show that the chronic
inhalation RfC is now available on IRIS. The chronic inhalation
RfC on IRIS was adopted as the subchronic inhalation [ RfCJ.
Bromoform
A comment was added to indicate that the chronic inhalation RfC is
considered not verifiable (02/11/93) by the RfD/RfC Work Group.
Chlorobenzilate
A comment was added to indicate that the chronic inhalation RfC is
considered not verifiable (02/11/93) by the RfD/RfC Work Group.
Cyanazine
No change in the tables. Reference to the 1993 Revised and Updated
Drinking Water Quantification of Toxicologic Effects for Cyanazine
was added.
Dinitro-o-cresol, 4,6 -
A comment was added to indicate that the chronic inhalation RfC is
considered not verifiable (02/11/93) by the RfD/RfC Work Group.
Endosul fan
The chronic oral RfD was withdrawn from IRIS (12/01/92) . The
chronic oral [ RfD] was changed to reflect the value currently under
review by the RfD/RfC Work Group (11/04/92). The chronic oral
[ RfDJ was adopted as the subchronic oral [ RfD].
Hexachlorobutadiene
The chronic oral RtD was withdrawn from IRIS (05/01/93) . The
hronic oral [ RfD] was changed to reflect the value currently under
review by the RfD/RfC Work Group (04/01/93)
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I sophorone
No change in the tables. Reference to 1993 Revised and Updated
Drinking Water Quantification of Toxicologic Effects for Isophorone
was added.
Methoxyethanol, 2 -
The chronic oral [ RfD] and the subchronic oral [ RfD] were moved
from Table 1 to Table 2 because they were derived from methodology
that is not current with the methodology used by the RfD/RfC Work
Group.
Methyl Ethyl Ketone
An indicator was added to show that the chronic oral RfD is now
available on IRIS.
Methylene-bis(2-chloroanhline), 4,4’ -
A comment was added to indicate that the chronic inhalation Rf C is
considered not verifiable (02/10/93) by the RfD/RfC Work Group.
Met r i bu z in
Added to Table 1. An indicator was added to show that the chronic
oral RfD is now available on IRIS. The chronic oral RED on IRIS
was adopted as the subchronic oral [ Rf D I.
Naphthalene
The record for Naphthalene, which was inadvertantly omitted from
Table 1 of the March 1993 Annual HEAST, has been replaced.
Nitroaniline, 2 -
The record for Nitroaniline, 2-, which was inadvertantly omitted
from Table 1 of the March 1993 Annual HEAST, has been replaced.
Trifluralin
No change in the tables. Reference to 1993 Revised and Updated
Drinking Water Quantification of Toxicologic Effects for
Trifluralin was added.
Zinc (metallic )
The record for Zinc (metallic), which was inadvertantly omitted
from Table 1 of the March 1993 Annual HEAST, has been replaced.
B. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 2: ALTERNATE
METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN
CARCINOGENICITY)
Methoxyethanol, 2 -
The chronic oral [ RfD] and the subchronic oral [ RfDJ were moved
from Table 1 to Table 2 because they were derived from methodology
that is not current with the methodology used by the RfD/RfC Work
Group.
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. CHEMICAL-SPECIFIC CHANGES ON HEAST TABLE 3: CARCINOGENICITY
Chioromethane
The record for Chloromethane, which was inadvertantly omitted from
Table 3 of the March 1993 Annual HEAST, has been replaced.
Cyanaz me
Carcinogenicity information was added to Table 3 from the 1993
Revised and Updated Drinking Water Quantification of Toxicologic
Effects for Cyanazine.
D. CHANGES ON HEAST TABLES 4A AND 4B: RADIONTJCLIDE CARCINO-
GENICITY — SLOPE FACTORS
No new radionuclide slope factors were added to Tables 4A and
48, and none of the slope factors listed in the March 1993 HEAST
Annual Update were changed.
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) July 1993
S chron$c ChronIc
CHEMICAl . DOSE SPECIES IRfCI (RiD) (RfCI (RiD) REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT ( mci/cu m) ( mci/kg/day) ( mg/cu m) ( mci/kg/day )
UF UF UF UF
BROMOETHENE 00059360-2
(VINYL BROMIDE)
LOAEL 9.7 PPM
RAT 3E•3 IRIS 010929
INHALATION: 24 MONTHS LIVER HYPERTROPHY 3000
INTERMITTENT LIVER BASOPHILIC FOCI
LIVER EOSINOPHILIC FOCI
SUBCHROWIC (RfC3 COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION (RfC).
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY:
BROMOFORM 000075-25-2
NOEL 17.9 MG/KG/DAY
RAT
ORAL: GAVAGE 13 WEEKS LIVER EFFECTS 2E1 IRIS 005722
100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHRONIC (RfC] COMMENT: THE CHRONIC INHALATION CRfC) IS CONSIDERED NOT VERIFIABLE (02/11/93) BY THE RfD/RfC WORK GROUP. 010930
CHLORCBENZILATE 000510-1 5-6
NOEL 5 MG/KG/DAY
RABBIT
ORAL: GAVAGE 13 DAYS GASTROINTESTINAL DECREASED STOOL QUANTITY 2E2 IRIS 010260
SYSTEM 300
WHOLE BODY DECREASED FOOD CONSUMPTION
WHOLE BODY DECREASED WEIGHT GAIN
NERVOUS SYSTEM HYPERIRRITABILITY
SUBCHRONIC (RfD) COMMENT: THE CHRONIC ORAL RfD ON IRIS WAS ADOPTED AS THE SIJBCHRONIC ORAL LRfD). BASED ON A TERATOLOGY STLK)Y WITH EXPOSURES
DURING DAYS 7-19 OF GESTATION.
CHRONIC (RfC) COMMENT: THE CHRONIC INHALATION (RfCJ IS CONSIDERED NOT VERIFIABLE (02/11/93) BY THE RfD/RIC WORK GROUP. 010931
IRIS, EPA’S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254. 1-1
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) JuLy 1993
Siàchronic ChronIc
CHEMICAL SPECIES (RfCJ (RfD) (RfCJ (RfDJ REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT ( mq/cu m) ( mqJkg/day) ( mg/cu m) ( mqjkg/day )
UF UF UF UF
CYANAZINE 021725-46-2
NOEL 0.625 MG/KG/DAY
DOG
ORAL: DIET 1 YEAR WHOLE BOGY DECREASED WEIGHT 2E-3 2E-3 010411
BLOOD INCREASED PLATELET COUNT 300 300
BLOOD ALTERED CLINICAL CHEMISTRY
PARAMETERS
SUBCHRONIC (RfDI COMMENT: THE CHRONIC ORAL CRfD3 WAS ADOPTED AS THE SUBCHRONIC ORAL (RfD].
CHRONIC CRfD] COMMENT: THE CHRONIC ORAL RID WAS WITHDRAWN FROM IRIS (07/01192). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
DINITRO0-CRESOL, 4,6- 000534-52-1
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT.
CHRONIC (RfCI COMMENT: THE CHRONIC INHALATION (RfC) IS CONSIDERED NOT VERIFIABLE (02/11193) BY THE RfQ/RfC WORK GROUP. 010470
ENDOSULFAN 000115-29-7
NOAEL 15 PPM
RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT GAIN 6E-3 6E-3 010926
KIDNEY GLOMERULONEPHROSIS 100 100
BLOOD VESSELS ANEURYSMS
NOAEL 10 PPM
DOG
ORAL: DIET 1 YEAR WHOLE BOGY DECREASED WEIGHT GAIN 010926
SUBCHRONIC (RfD) COMMENT: THE ORAL CHRONIC (RfD] IS ADOPTED AS THE SZJBCHRONIC ORAL CRfDJ.
CHRONIC (RfD] COMMENT: WITHDRAWN FROM IRIS (12/01/92). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
IRIS 5 INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER 4ATION: IRIS USER SUPPORT: (513) 569-7254.
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARC NOGENICITY) July 1993
S chronIc Chronic
CHEMICAL DOSE SPECIES CRfC3 (RfDJ CRfC] (RfDJ REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT ( mq/cu n) ( mq/kg/day) ( mq/cu m) ( mq/kg/day )
UF UF UF UF
HEXACHLOROBUTADIENE 000087-68-3
LOAEL 0.5 MG/KG/OAT
MOUSE
ORAL: DIET 13 WEEKS RENAL TUBULES REGENERATION 2E-4 010927
1000
CHRONIC (RfDJ COMMENT: WITHDRAWN FROM IRIS (05/01/93). UNDER REVIEW. CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
SUBCHRONIC (RfC COMMENT: CONTACT THE SUPERF(JND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300. 010902
SUBCKROIIIC (RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300. 010902
ISOPHORONE 000078-59-1
NOEL 150 HG/KG/DAY
DOG
ORAL: CAPSULE 90 DAYS KIDNEY LESIONS 2E+0 IRIS 005910
100
IRIS 010906
CHRONIC (RfCJ COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (11/15/90) BY THE RfD/RfC WORK GROUP.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3; CARCINOGENICITY.
METHOXYETHANOL. 2- 0001 09-86-4
NOAEL 93 MG/cU N
RABBIT
INHALATION: 13 WEEKS TESTICLE EFFECTS 2E-1 IRIS 010372
INTERMITTENT 100
SUBCHRONIC (RfD) COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHRONIC (RfD COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS, EPA’S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254. 1-3
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) July 1993
Subchron lc Chronic
CHEMICAL SPECIES (RId (RID] CRIC] (RID] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT ( mci/cu m) ( mg/kg/day) ( mci/cu m) ( mci/kg/day )
UF UF UF UF
METHYL ETHYL KETONE 000078-93-3
WOAEL 1711 HG/KG/DAY
RAT
ORAL: DRINKING MULTI-GENERA FETUS DECREASED BIRTH WEIGHT 2E-1 IRIS 010853
WATER TION 1000
SUBCHRONIC (RfOJ COMMENT: THE CHRONIC ORAL RID WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL (RID] -
GENERAL COMMENT: MULTI-GENERATION DEVELOPMENTAL STUDY PERFORMED WITH THE SURROGATE 2-SUTANOL , A METABOLITE OF METHYL ETHYL KETONE.
NOAEL 1010 PPM
MOUSE
INHALATION: 10 DAYS FETUS DECREASED BIRTH WEIGHT 1E+1 IRIS 010845
INTERMITTENT 3000
SIJBCHRONIC (RIC3 COMMENT: THE CHRONIC INHALATION RIC ON IRIS IS ADOPTED AS THE SUBCHRONIC INHALATION (RfCI.
METHYLENE-BIS(2-CHLOROANILINE), 4,4’- 000101-14-4
LOAEL 7.3 MG/KG/DAY
DOG
ORAL 9 YEARS LIVER EFFECTS 7E-4 TE-4 010413
BLADDER EFFECTS 10000 10000
CHRONIC (RfCJ COMMENT: THE CHRONIC INHALATION (RIC3 IS CONSIDERED NOT VERIFIABLE (02/10/93) BY THE RID/RIC WORK GROUP. 010933
METRIBUZIN 021087-64-9
NOAEL 100 PPM
DOG
ORAL: DIET 2 YEARS LIVER EFFECTS 2.5E-2 IRIS 010928
KIDNEY EFFECTS 100
WHOLE BODY MORTALITY
WHOLE BODY DECREASED WEIGHT
SUBCHRONIC (RfDJ COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL (RID].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS ‘S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER AATION: IRIS USER SUPPORT: (513) 569-7254.
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HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY) JuLy 1993
Subchronic Chronic
CHEMICAL Q5 SPECIES ( MC I (RfDJ (MC I (MD ] REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT ( mg/cu m) ( ingjkg/day) ( irn/cu m) ( mg/kg/day )
UF UF UF UF
NAPHTHALENE 000091-20-3
CHRONIC (MD ] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300. 010934
NITROANILINE, 2- 000088-74-4
LOAEL 9.8 HG/EU H
RAT
INHALATION: 4 WEEKS BLOOD HEI4ATOLOGICAL EFFECTS 2E-3 2E-4 010935
INTERMITTENT 1000 10000
CHRONIC (RfD] COMMENT: THE CHRONIC ORAL RfD IS CONSIDERED NOT VERIFIABLE (06/23/92) BY THE RID/RfC WORK GROUP. 010936
TRIFLURALIN 001582-09-8
NOEL 0.75 MG/KG/DAY
DOG
ORAL: DIET 12 MONTHS LIVER INCREASED WEIGHT 7.5E3 IRIS 010080
BLOOD METHEMOGLOBINEHIA 100
SUBCHRONIC (RID] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUSCHRONIC ORAL (RID].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ZINC (METALLIC) 007440-66-6
LOAEL 1.0 MG/KG/DAY
HUMAN
ORAL: DIET 10 WEEKS BLOOD DECREASED BK000 ENZYME 3E-1 IRIS 010937
SUBCHRONIC (RID] COMMENT: THE CHRONIC ORAL RfD ON IRIS WAS ADOPTED AS THE SUBCHRONIC ORAL (RfD ].
IRIS. EPA’S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254. 1-5
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HEAST TABLE 2: ALTERNATE METHOL, 0 - SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) - July 1993
Subchronic Chronic
CHEMICAl . DOSE SPECIES (RfCJ (RfD] (RfC) CRfDJ REFERENCE
LEVEL ROUTE EXPERIMENT LENGTH TARGET CRITICAL EFFECT ( mg/cu m) ( mg/kg/day) ( mg/cu in) ( mg/kg/day )
UP UP UP UP
METHOXYETHANOL, 2- 000109-86-4
NOAEL 31 MG/DJ N
RABBIT
INHALATION: 13 WEEKS TESTICLE EFFECTS 1E-2 1E-3 010910
INTERMITTENT 100 1000
SUBCHRONIC ( MD ] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC (Rf03 COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
GENERAL COMMENT: ALSO SEE TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAW CARCINOGEIIICITY).
IRIS, EPA’S INTEGRATED RISK INFORMATION SYSTEM, IS UPDATED MONTHLY. FURTHER INFORMATION: IRIS USER SUPPORT: (513) 569-7254. 2-1
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HEAST TABLE 3: CARCINOGENICITY JuLy 1993
(SLOPE FACTORI (UNIT R IS 1
EXPERI NT LENGTH (EPA ORAL INHALATION ORAL INHALATION REFERENT
CHEMICAL ROUTE SPECIES TA2 T CANCER GROUPI (uiIg/kg/day)’(.BlkWday)’ ( /L)’ ( /cu m)-1
CHLOROMETHANE 000074-87-3
INHALATION: 24 MONTHS C 1.3E-2 6.3E-3 3.7E-7 1.8E-6 005038
INTERMITTENT MOUSE KIDNEY TUMORS
ORAL (SLOPE) COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: SUBCHROW IC AND CHRONIC TOXICITY (OTHER THAW CARCINOGENICITY).
CYANAZINE 021725-46-2
ORAL: DIET 2 YEARS C 8.4E-1 2.4E-5 010932
RAT MAMMARY GLAND CARCIWOSARCOMAS
MAMMARY GLAND ADENOSARCOMAS
GENERAL COMMENT: ALSO SEE HEAST TABLE 1: CHRONIC AND SUBCHROMIC TOXICITY (OTHER THAN CARCINOGENICITY).
IRIS EPA’S INTEGRATED RISK INFORMATION SYSTEM IS UPDATED MONTHLY. FURTHER iNFORMATION: IRIS USER SUPPORT: (513) 569-7254. 3-1
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) JuLy 1993
BROMOETHENE 000593-60-2
010929 BENYA TJ , M BUSEY, MA CORATO AND PE BERTEAU. 1982. INHALATION CARCINOGENICITY BIOASSAY OF VINYL BROMIDE IN RATS. TOXICOL APPL
PHARMACOL. 64(3): 367-379.
BUSEY 1A4. 1979. ONCOGENIC POTENTIAL OF VINYL BROMIDE DURING CHRONIC INHALATION EXPOSURE - RATS: PATHOLOGY REPORT. EPA/OTS 8EHO-0479-
0281.
US EPA. 1993. RfD/RfC WORK GROUP.
BROMOFORM 000075-25-2
005722 NTP (NATIONAL TOXICOLOGY PROGRAM). 1989. TOXICOLOGY AND CARCINOGENICITY STUDIES OF TRIBROMOMETHAWE AND BROKOFORN IN F344 RATS AND
B6C3FI MICE (GAVAGE STUDIES). NTP-35O.
US EPA. 1989. HEALTH AND ENVIRONMENTAL EFFECTS DO IJ1ENT FOR BROMOFORM. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE, WASHINGTON, DC.
US EPA. 1987. HEALTH AND ENVIRONMENTAL ASSESSMENT FOR TRIHALOGENATED METHANES. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE,
WASHINGTON, DC.
US EPA. 1987. RfD/RfC WORK GROUP.
010930 US EPA. 1993. RfD/RfC WORK GROUP.
CHLOROBENZILATE 000510-1 5-6
010260 CIBA-GEIGY CORPORATION. 1984. MRID NO 00144691.
US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR CHLOROBENZILATE. PREPARED BY THE ENVIRONMENTAL CRITERIA AND ASSESSMENT
OFFICE, OFFICE OF HEATH AND ENVIRONMENTAL ASSESSMENT, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE.
US EPA. 1989. RfD/RfC WORK GROUP.
010931 US EPA. 1993. RfD/RfC WORK GROUP.
RI-i
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) .Iuty 1993
CYANAZINE 021725-46-2
010411 (1 DU PONT CE NEMOIJRS AND COMPANY, INC. 1986. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. NRID NO. 40081901 AND 40229001.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR CYAMAZINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON, DC.
US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR CYAWAZIWE. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, Oil FOR THE OFFICE OF WATER,
WASHINGTON, DC.
US EPA. 1992. RfD/RfC WORK GROUP.
DINITRO-O-CRESOL, 4,6. 000534-52-1
010470 US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR DINITROCRESOLS. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON 1 DC.
US EPA. 1993. RfD/RfC WORK GROUP.
ENDOSULFAN 000115-29-7
010926 HOECHST CELANESE CORP. 1989A. EWDOSULFAN: 2-YEAR FEEDING/ONCOGENICITY IN RATS. MRID NO. 40256502. 41099502. MED DX. NO. 007937.
HOECHST CELANESE CORP. 19898. ENDOSULFAN: 1-YEAR FEEDING STUDY IN DOGS. MRID. NO. 41099501. HED NO. 007937
US EPA. 1992. RfD/RfC WORK GROUP.
HEXALCHLOROROBUTADIENE 000087-68-3
010927 NTP. 1991. NTP REPORT ON THE TOXICITY STUDIES OF HEXCHLORO-1,3-BUTADIENE IN B6C3FI MICE (FEED STUDIES).
YANG ET AL. 1989. HEXACKLOROBUTADIENE - SUBCHROMIC TOXICOLOGY STUDIES OF HEXACHLORO-1,3-BUTADIENE (HCBD) IN B6C3F1 MICE BY DIETARY
INCORPORATION. J. ENVIRON. PATHOL. TOXICOL. ONCOL. P. 323-332.
KOCIBA RJ, DG KEYS, CC JERSEY, ET AL. 1977. RESULTS OF A 2-YEAR CHRONIC TOXICITY STUDY WITH HEXACHLORO8UTADIENE IN RATS. AM IND HYG
ASSOC J 38: 589-602.
US EPA. 1993. RfD/RfC WORK GROUP.
010902 US EPA. 1992. SUPERFLJND HEALTH RISK TECHNICAL SUPPORT CENTER.
Ri
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1993
ISOPHORONE 000078-59-1
005910 NOR-AM AGRICULTURAL PRODUCTS, INC. 1972. MRID NO 00123976. AVAILABLE UNDER FOI, EPA, WASHINGTON, DC, 20460.
NTP (NATIONAL TOXICOLOGY PROGRAM). 1986. TOXICOLOGY AND CARCINOGENESIS STUDIES OF ISOPHORONE (CAS NO 78-59-1) IN F344/N RATS AND
86C3F1 MICE (GAVAGE STUDIES). NIP TECH REPORT SER NO 291, NIH PUBL NO 86-2547.
US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR ISOPHOROIIE. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER,
WASHINGTON, DC.
010906 US EPA. 1990. RID/RfC WORK GROUP.
METHOXYETHANOL, 2- 000109-86-4
010372 MILLER RR, JA AYRES, JI YOUNG ET AL. 1983. ETHYLENE GLYCOL MOHOHETHYL ETHER. I. SUBCHRONIC VAPOR INHALATION STUDY WITH RATS AND
RABBITS. FUND APPL TOXICOL 3(1):49-54.
US EPA. 1990. RtD/RIC WORK GROUP.
METHYL ETHYL KETONE 000078-93-3
010853 COX GE. 1975. TOXICITY STUDIES IN RATS WITH 2-BUTANOL: INCLUDING GROWTH, REPRODUCTION. AND TERATOLOGIC OBSERVATIONS. FOOD AND DRUG
RESEARCH LABORATORIES, INC. (91MR R 1673)
US EPA. 1992. RfD/RfC WORK GROUP.
010845 SCHWETZ, BA, TJ MAST, RJ WEIGEL, ET AL. 1991 DEVELOPMENTAL TOXICITY OF INHALED METHYL ETHYL KETONE IN MICE. FUND APPL TOXICOL.
16: 742-748.
MAST, TJ, JA DILL, JJ EVANOFF, ET AL. 1989. INHALATION DEVELOPMENTAL TOXICOLOGY STUDIES: TERATOLOGY STUDY OF METHYL ETHYL KETONE IN
MICE. FINAL REPORT. PREPARED BY PACIFIC NORTHWEST LABORATORY, BATELLE MEMORIAL INSTITUTE, FOR THE NATIONAL TOXICOLOGY PROGRAM,
WASHINGTON, DC. PNL 6833 UC-4O8.
US EPA. 1991. RfD/RfC WORK GROUP.
METHYLENE-BIS(2-CHLOROANILINE), 4,4’- 000101-14-4
010413 STULA (F, JR BARNES, H SHERMAN, CF REINHARDY AND JA ZAPP. 1977. URINARY BLADDER TUMORS IN DOGS FROM 4,4’-METHYLENE-BIS(2-
CHLOROANILINE) (MOCA). J ENVIRON PATHOL TOXICOL. 1(1): 31-50.
US EPA. 1990. HEALTH AND ENVIRONMENTAL EFFECTS DOCUMENT FOR 4,4’-METHYLEWE-BIS(2-CHLOROANILINE). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON DC.
010933 US EPA. 1993. RfD/RfC WORK GROUP.
R1-3
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REFERENCES FOR HEAST TABLE 1: SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) July 1993
METRIBUZIN 021087-64-9
010928 MOBAY CHEMICAL CORPORATION. 1974. MRID 000061260. AVAILABLE FROM EPA. WRITE TO F0I, WASHINGTON, DC 20460.
US EPA. 1986. RfD/RfC WORK GROUP.
US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR METRIBUZIN. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER,
WASHINGTON, DC.
NAPHTHALENE 000091-20-3
010934 US EPA. 1992. SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER.
NITROANILINE, 2- 000088-74-4
010935 610/DYNAMICS. 1983. PROJECT NO. (Bo-82 270). A FOUR WEEK INHALATION STUDY OF ORTHO-NITROANILINE IN MALE RATS. FINAL REPORT. SUBMITTED
TO DR. RASHMI HAIR, MONSANTO CO., AUGUST 16, 1963. EPA 87821478. #0TS0206486. P. lA-I ?, 32-42, 46-48, 55-58. 62-67.
US EPA. 1985. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR NITROANILINE (0-, M-, P-). PREPARED BY THE OFFICE OF HEALTH AND
ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY
RESPONSE, WASHINGTON, DC.
US EPA. 1991. HEALTH AND ENVIRONMENTAL EFFECTS DOQJMEMT FOR 2 NITROANILINE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
010936 US EPA. 1992. RfD/RfC WORK GROUP.
TRIFLURALIN 001582-09-8
010080 HOECHST AKTIENGESELLSCHAFT. 1984. CONFIDENTIAL BUSINESS INFORMATION, UNPUBLISHED STUDY. MRID NO 00151908.
US EPA. 1984. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR TRIFLURALIN. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE, WASHINGTON, DC.
US EPA. 1989. RfD/RfC WORK GROUP.
US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR TRIFLURALIN. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER,
WASHINGTON, DC.
ZINC (METALLIC) 007440-66-6
010937 YADRICK, MF, MA KENNEY AND EA WINTERFELDT. 1989. IRON, COPPER AND ZINC STATUS: RESPONSE TO SUPPLEMENTATION WITH ZINC OR ZINC AND IRON
IN ADULT FEMALES. AM J CLIN NUTR. 49:145-150.
US EPA. 1991. RfD/RfC WORK GROUP.
R i
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REFERENCES FOR HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY) JULY 1993
METHOXYETHANOL. 2- 000109-86-4
010910 MILLER RR LI CAU OUN, BI YANO. 1982. ETHYLENE GLYCOL MONOMETHYL ETHER. 13-WEEK VAPOR INHALATION STUDY IN MALE RABBITS. REPORT
PREPARED FOR THE CM MARCH 25 1982.
US EPA. 1986. HEATLH AND ENVIORNMENTAL EFFECTS PROFILE FOR 2-METHOXYETHANOL. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENTS ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE,
WASHINGTON, DC.
R2-1
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REFERENCES FOR HEAST TABLE 3: CARCINOGEN ICITY JuLy 1993
CHIOROMETHANE 000074-87-3
005038 CUT (CHEMICAL INDUSTRY INSTITUTE OF TOXIcOLOGY). 1981. FINAL REPORT ON 24-MONTH INHALATION STUDY ON METHYL CHLORIDE. PREPARED BY
BATTELLE-COLUMBUS LABORATORIES, COLUMBUS 1 OH DECEMBER 31.
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MONOHALOMETHANES. NTIS P885-111623.
US EPA. 1986. HEALTH AND ENVIRONMENTAL EFFECTS PROFILE FOR METHYL CHLORIDE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL
ASSESSMENT 1 ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE 1 CINCINNATI 1 OH FOR THE OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE 1
WASHINGTON 1 DC.
US EPA. 1987. HEALTH EFFECTS ASSESSMENT FOR CHLOROMETHANE. PREPARED BY THE OFFICE OF HEALTH AND ENVIRONMENTAL ASSESSMENT,
ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF EMERGENCY AND REMEDIAL RESPONSE, WASHINGTON, DC.
CYANAZINE 021725-46-2
010932 El DU PONT DE NEMOURS & CO 1990. COMBINED CHRONIC TOXICITY/ONCOGENICITY STUDY WITH CYANAZINE IN RATS. HASKELL LABORATORY. STUDY NO.
23-90. MRID NO. 41509902. (REVIEWED BY DYKSTRA, 1991).
DYKSTRA W. 1991. PEER REVIEW OF CYANAZINE (BLADEX). CAS NO. 21725-46-2. EPA CHEN. C X E: 100101, CFR NO. 180.307. INTERNAL MEMORANDUM
TO L ROSSI AND J AUERBACH, OFFICE OF PESTICIDES AND TOXIC SUBSTANCES, US EPA, WASHINGTON, DC. JULY 30.
US EPA. 1993. REVISED AND UPDATED DRINKING WATER QUANTIFICATION OF TOXICOLOGIC EFFECTS FOR CYANAZINE. PREPARED BY THE OFFICE OF
HEALTH AND ENVIRONMENTAL ASSESSMENT, ENVIRONMENTAL CRITERIA AND ASSESSMENT OFFICE, CINCINNATI, OH FOR THE OFFICE OF WATER,
WASHINGTON, DC.
R3- 1
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