Case Number 102 GUIDANCE FOR THE REREGISTRATION OF MANUFACTURING-USE AND CERTAIN END-USE PESTICIDE PRODUCTS CONTAINING DISULFOTON (032501) CAS 298-04-4 ENVIRONMENTAL PROTECTION AGENCY OFFICE OF PESTICIDE PROGRAMS WASHINGTON, D.C. 20460 DECEMBER, 1984 ------- Workgroup Robert O’Brien Bill Boodee Dave Brassard George Chali Tom Parshley Hudson Boyd Ed Fite John Tice (BUD/PQUA) (RCB) (BUD/INDEX) (TOX) (RD) (EAB) (EEB) (SIS/HED) ------- TABLE OF CONTENTS I ntroduction . . . . . . . . • , . . • • • • • • • • • 1 i. Regulatory Position. . . . . . . . . . . . . . . . . . 4 ii. Requirement for Submission of Generic Data . . . 40 iii. Requirement for Submission of Product—Specific Data S S I S S S iv. Submission of Revised Labeling and Packaging Information. • . . 86 A. Label Contents . . . . . . . . 86 1. Product Name • • • • • • . . • 86 2. Company Name and Address . . . . . . . . . . . 86 3. Net Contents . . . . . . . . . . . . . . . . . 86 4. Product Registration Number. . . . . . . . . . 86 5. Producing Establishment Registration Number. . . . . . . . . . • . . . 87 6A Ingredient Statement . . . . . . . . . • . . . 87 6B pounds Per Gallon Statement. . . 87 7. Front Panel Precautionary Statements . . . . . 7E 7A Child Hazard Warning Statements. . . . • . . . 87 7B Signal Word. . . . . . . . . . . . . . . . . . 87 7C Skull and Crossbones and Word Poison . . . . . 88 7D Statement of Practical Treatment . . . • . . . 88 7E Referral Statement . . . . . . . 88 8. Side/Back Panel Precautionary Labeling . . . . 88 8A Hazard to Humans and Domestic Animals. . . . . 88 8B Environmental Hazard . . . . . . . . . . . . . 88 8C Physical or Chemical Hazard. . . . . . . . . . 88 9. Product Classification . . . . . . . . . . . . 89 10. Misuse Statement . . . . . . . . . . . . . . . 91 hA Storage and Disposal Block . . . . . . . . . . 91 I1B Directions for Use . . . . . . . . . . . . . . 91 B. Collateral Information . . . . . . . . . . . . . . 91 V. Instructions for Submission. . . . . . . . . . . . . . 92 1 ------- APPENDICES Bibliography •..............................S..... li—i FIFRA §3(c)(2)(B) Summary Sheet — EPA Form 8580—1 .. ..... 11—2 Certification of Attempt to Enter Into an Agreement With Other Registrants for Development of Data EPA Form 8580—6 •. .. . . ............. .... .. 11—3 Product Specific Data Report (End—Use Products)... 111—1 Sample Label Formats . . . . . . . . . . . . . . . . . . . . . . . . . . . . IV—1 Table of Labeling Requirements ......... .......... Iv—2 Physical/Chemical Hazards Labeling Statement ..... IV—3 Storage and Disposal Instructions................. IV—5 Note: Appendices IV—4 and IV—6 are not germane to this document and are not included. ii ------- INTRODUCTION The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA sec. 3(g), as amended in 1978, directs EPA to reregister all pesticides as expeditiously as possible. Each registrant of a manufacturing use product (MP) containing disulfoton as the sole active ingredient who wishes to continue to sell or distribute that product must apply for reregistration under and fulfill the requirements described in this standard. Although the full requirements for reregistration do not apply to other products containing disulfoton at this time, registrants with such products are subject to various provisions of this standard as follows. Each registrant of a MP containing disulfoton in combination with other active ingredients is required to comply with the data requirements set forth in Table A and B of their documents, labeling revisions and reregistration are not required at this time. Each registrant of an end use product (EP) containing disulfoton as a sole active ingredient or in combination with other active ingredients are subject to the labeling and data requirements (refer to Table C) in this standard. To carry out the task of reregistration, we have established the Registration Standards program, which will review all pesti- cide active ingredients first registered before January 1, 1977. These pesticides will be reviewed in use clusters which are prioritized on the basis of a ranking scheme giving preference to pesticides used on food and feed crops. The Registration Standards program involves a thorough review of the scientific data base underlying pesticide registrations and an identification of essential but missing studies which may not have been required when the product was initially registered or studies that are now considered insufficient. Our reassessment results in the development of a regulatory position, contained in this document, on each pesticide and its uses. Based on the regulatory position, the Agency may require the registrant to modify product labels to provide additional precautionary statements, restrict the use of the pesticide to certified applicators, provide reentry intervals, modify uses or formulation types, specify certain packaging limitations, or other requirements to assure that proper use of the pesticide poses no potential adverse effects to human health or the environment. The scientific review, which is not contained in this Guidance Package but is available upon request, concentrates on the technical grade of the active ingredient and identifies missing generic data. However, during the review of these data we are also looking for potential hazards that may he 1 ------- associated with the formulated (end use) products that contain the active ingredient. If we find serious concerns, we will bring formulated products under the provisions of the Registration Standards program to the extent necessary to protect the public. EPA has the authority under FIFRA §3(c)(2)(B) to require that registrants submit data that will answer our questions regarding the hazard that may result from the intended use of the pesticide under review. Further, §3(c)(2)(B) provides that these data are to be submitted by those registrants who do not qualify for the formulator’s exemption EFIFRA §3(c)(2)(D)J . Normally, this means that the registrants who are responsible for filling the data gaps are the manufacturing use product producers (basic suppliers of the active ingredient). However, end use producers will not qualify for the formulator’s exemption if the source of their active ingredient: (1) is not registered with EPA, and/or (2) is produced by the regis- trant’s firm, or a firm which has ownership in common with the registrant’s firm. These end use producers can qualify for the formulator’s exemption if they change their source of supply to a registered source, provided the source does not share ownership in common with the registrant’s firm. If the end use product registrant decides to switch sources, a new Confidential Statement of Formula, EPA Form 8570—4, must be submitted to the appropriate Product Manager within 90 days of receipt of this Guidance Document. The chart on the following page shows what is generally required of those who do and do not qualify for the formulator’s exemption in the Registration Standards program. If you decide to request the Agency to cancel the regis- tration of any of your products subject to the reregistration requirements of this Guidance Document, please notify the Product Manager named in the cover letter, within 90 days from the receipt of this document, that you wish to voluntarily cancel the registration(s) . If you decide to maintain your product registration(s), you must provide the information described in the following pages within the timeframes outlined. EPA will issue a notice of intent to cancel or suspend the registration of any currently registered product if you fail to comply with the requirements set forth in this Guidance Document. You are reminded that FIFRA sec. 6(a)(2) requires you at any time to submit factual information raising concerns of possible unreasonable adverse effects of a pesticide. You should notify the Agency of interim results of studies in progress if those results show possible adverse effects. 2 ------- PE JWCTS SUBJECr ‘10 ThE REGI RATION SIANE1 IRLS P1 )GBAM ACTIC14( S) REY UIRED 10 M1 I AIN REGISTRATION I. Products That 1X Not Qualify For The Formulator’s Exemption A. Single Active Ingredient ProduCts* SI•• .•• . •I•• ••I •I •• •e•• •.. B. Multiple Active Ingredient Products These products must be reregis— tered. 1 obtain reregistration, labeling, packaging and data requir nents must be satisfied in accordance with the Regis- trat ion Standards Guidance DDc ment. S..... SS•SI These products will not be reregistered at this tine. However, generic data required to continue the registration of the active ingredient under review, as described in the Registration Standards Guidance Dcun nt, will be required and sate labeling precautions may also be required. II. Products That DD Qualify For The Formulator’s Exemption In the case of this standard that requires restrictions and labeling to protect man and the envirorment, these products are subject to certain provisions in this Registration Standard. Affected products are to be called in as provided for in this docurtent. * E id use products of registrants who also produce a manufacturing use product will not be required to be reregistered provided that registrant fulfills the requir tents specified in the Guidance I)Dcl ntent for manufacturing use product(s). Such end use products will be subject to the labeling changes required for products in “ii above. If there are no manufacturing use products registered by any canpany end use products will be required to be reregistered, that is neet the full data requirenents, labeling requirements, (as appropri- ate) and 3(c)(l)(D) requirements imposed by this docunent. NOlE: If all registrants in “I” above fail to meet the requir rents in I—A and B above, then the registrants in NIlU lose their right to qualify for the formulator’s exemption and becane sub)ect to the requirements in I—A and B. 3 ------- I. Regulatory Position A. Introduction This Registration Standard describes the regulatory position of the Environmental Protection Agency (EPA) on manufacturing—use products (MUP’s) and certain end—use products (EUP’s) containing the insecticide disulfoton as a sole active ingredient. The Agency’s position is based on an evaluation of all registered uses of disulfoton and registered MUP’s with disulfoton as an active ingredient. This document provides the rationale for the Agency’s position and the criteria for registration that result from it. It also discusses labeling requirements and tolerances. Finally, it considers Special Local Needs registrations, authorized by Section 24(c) of the Federal Insecticide Fungicide and Rodenticicle Act (FIFRA), as an ended, in addition to federal registrations granted under Section 3 of the FIFRA. Future products that differ appreciably from those described in this Standard may require an amendment to this Standard to reflect the difference. No new uses for disulfoton will be considered until the human and environmental concerns raised in this Standard are satisfactorily resolved. 4 ------- B. Chemical Description and Use Profile Disulfoton is the common name for 0, 0—diethyl S— [ 2—(ethylthio) ethyl] phosphorodithioate. Trade names and other names include ethylthiodemeton, Disyston, dithiodemeton, dithiosystox, and thiodemeton. The chemical is manufactured in the U. S. by Mobay Chemical Corp. The empirical formula is C8H 1 9O2PS3 and the molecular weight is 274.4. The structural formula is as follows: S It (C 2 H SO)2 — PSCH 2 CH 2 SC2H S The 95% technical material also serves as a manufacturing—use product under the trade name Di—Syston. Technical disulfoton is a pale yellow liquid which hydrolyzes under alkaline conditions, with a boiling point of 62°C at 0.01 mm/Hg. It is soluble in most organic solvents and is soluble in water at 25 parts per million (ppm) at 20°C. Other physical and chemical properties are vapor pressure 1.8 X l0 millibars at 20°C, and specific gravity 1.144 at 20°C/4°C. Existing data gaps relating to product chemistry are identified in Table A and Table B. There are five manufacturing—use products, 70 federally registered Section 3 end—use products, 41 24(c) Special Local 5 ------- Need registrations, and 34 intrastate products containing disulfoton as the sole active ingredient. There are also a number of products containing disulfoton in combination with other active ingredients. These multiple active ingredient products include one multiple active ingredient manufacturing— use product containing disulfoton, 29 federally registered Section 3 end—use products, four 24(c) Special Local Need registrations, and 11 intrastate products. The formulation types of the above products include granulars, pelleted/tableted, emulsifiable concentrates, and ready—to—use liquids. Disulfoton is formulated in various percentages in combination with benefin, chlorobenzilate, demeton, diazinon, dicofol, ethoprop, fensulfothion, PCNB, etridiazole, trifluralin, and vernolate. Disulfoton, a plant systemic organophosphate chemical, is principally used as an insecticide/acaricide for the agricultural crops cotton, sorghum, and wheat. Additional registered uses include the agricultural crops alfalfa, corn, peanuts, soybeans, tobacco, pecans, various seed crops, certain fruits and vegetables, ornamentals and nursery stock, forest uses, greenhouse uses, and potted house plants. Most granular disulfoton products are applied as pre—plant or at—planting soil treatments, although emulsifiable concentrates 6 ------- and ready—to—use liquids can be applied either aerially or by ground equipment. Certain formulations containing 10% or greater concentrations of disulfoton are already classified for Restricted Use (44 CFR 45131 Aug., 1, 1979) based on dermal and/or inhalation toxicity. C. Regulatory Position and Rationale Based on a review and evaluation of all available data and other relevant information on disulfoton, the Agency has made the following determinations: 1. An interim farm worker reentry interval of 24 hours is necessary for disulfoton under this Standard pending receipt and evaluation of reentry studies noted in Table A. Rationale: The Agency is concerned about possible dermal and inhalation exposure to farm workers because of disulfoton’s high acute toxicity. In order to assess this potential risk, reentry studies (dermal exposure, inhalation exposure, foliar dissi- pation and soil dissipation studies) and toxicity (dermal absorption) data are required to be submitted. In the absence of such data interim reentry intervals will be utilized to minimize exposure to workers entering treated fields. 7 ------- 2. Product integrity studies on typical end—use disulfoton granular formulations are being required to assess hazards from inhalation and dermal exposure to workers and handlers from granular formulations of disulfoton. Rationale: Based on present use patterns and application practices there would appear to be little likelihood of exposure to workers resulting from the handling and use of the disulfoton granular formulations. However, should the granules fracture during shipping and handling, an inhalation and dermal exposure hazard to handlers and other workers subject to prolonged exposure may occur. Therefore, product integrity studies are being required to assess this possibility. Depending on results of these studies, additional precautionary labeling and! or other protective measures, as appropriate, will be implemented. In addition, a subchronic inhalation exposure study (90—day rat) and a subchronic dermal study (21—day) may be required. 3. Disulfoton and its degradation products have potential to leach through soil and contaminate ground water; however the available data is insufficient to character- ize this potential. Additional studies are being requested. These studies include hydrolysis, metabolism 8 ------- and mobility studies. Once these additional studies are submitted and reviewed an environmental fate assessment on disulfoton and its metabolites and their potential for ground water contamination can be made. Rationale : Preliminary information indicates that disulfoton has a low to intermediate mobility in soils. The mobility of its inetabolites are somewhat greater. Because disulfoton is mainly applied by soil incor- poration, the mobility potential is further enhanced. The half—life and leaching potential of disulfoton and its degradates are unknown; however, it is believed that the degradates may persist in the soils for a relatively long period of time. 4. The “restricted use” classification for all disulfoton emulsifiable concentrates 65%, 21% (w/ FensulfothiOrl 43% and greater) or 32% (w/ fensulfothiOn 32% and greater) and greater, and ready—to—use liquids 95% and greater, and granular formulatiOns 10% and greater (for greenhouse use) will continue . All remaining end—use product formulations greater than 2% are hereby classified for “restricted use” on an interim basis by this Standard, pending receipt and 9 ------- evaluation of additional data specified in Table C. All end—use product formulations 2% and less are not now being classified “restricted use” pending receipt of toxicity data specified in Table C. Rationale: The emulsifiable concentrates and ready— to—use liquids, and granular formulations 10% and greater (greenhouse use) were previously restricted by regulation on August 1, 1979 (40 CFR 162.31). Classification for the EC and liquids was based upon acute dermal and acute inhalation toxicity, and for the granulars for greenhouse use was based on acute inhalation toxicity. Though granular formulations containing greater than 2% disulfoton were previously proposed for restricted use on August 1, 1979 (44 FR 54219), the Agency never promulgated a final rule classifying these formulations. All product formulations greater than 2% are being restricted through this Standard. All product formulations greater than 2% released for shipment after September 1, 1985 must be labeled for restricted use. All such products which are in the 10 ------- channels of trade after September 1, 1986 must be labeled for restricted use. The September 1, 1985 date for products released for shipment provides time for States to certify applicators and also assures that most products used in the 1986 growing season will be classified for restricted use. Requiring all products still in the channels of trade after September 1, 1986 to be so restricted will prevent stockpiling by dealers and distributors and assure that all products greater than 2% available for the 1986 growing season are restricted. The decision to classify some disuifotOn registrations as restricted use products was based on criteria set out in §162.11(c). The principal human effects triggers for chemicals used in non—domestic settings are the Toxicity Category I criteria, i.e., acute dermal LDSO — 200 mg/kg; acute inhalation LC5O — 0.2 mg/i; acute oral LD5O — 50 mg/kg. The principal human effects triggers for pesticides used in domestic settings are the Toxicity II criteria. Current disulfoton end use product labels carry Toxicity Category I, II, III designations. Based on extrapolation of available acute oral toxicity data in our files non—domestic use products containing 3.38% or more 11 ------- disulfoton would fall in Toxicity Category I and domestic use products greater than O.3%* in Toxicity Category II and thus would be candidates for restricted use classification. The acute toxicity data base for end—use products containing disulfoton is not adequate for the Agency to make a final determination which formulations warrant the restricted—use classi- fication. Therefore the Agency will require products greater than 2% disulfoton to be classified for re- stricted use until appropriate toxicity studies and other information is received. When the acute toxicity data base is complete, the Agency will review its decision regarding the classification of registered products containing more than 2% disulfoton. (Refer to Data Table C). The majority of current disulfoton products are registered for use on agricultural crops, commercially grown ornamentals and limited forestry uses. However, there are a number of products formulated at 2% and less for use primarily by the homeowner for vegetables, flowers and potted houseplants, which remain unclassified. *Assumptions: A 10 kg female consumes lOg of granular material containing .03g of chemical (96% pure) and complete rapid absorption takes place. Calculated from 3.38% disulfoton. 12 ------- The acute toxicology data base for disulfoton end use products is severely lacking. The Agency has decided not to classify product formulations containing 2% or less as restricted use pending receipt and evaluation of appropriate toxicity data required under this Standard (refer to Data Table C). After receipt of this data the Agency will consider the acute toxicity categories for those products 2% or less and current label language to determine if these products warrant restricted use classification. 5. The Attwater’s greater prairie chicken, Aleutian Canada Goose, the Everglades kite, Slackwater darter, woundfin, 11 freshwater mussels, longhorn beetle, delta green ground beetle, and Kern primrose sphinx moth, all endangered species, may be at risk from the use of disulfoton. The Agency has decided to adopt a generic (cluster) approach for addressing endangered species concerns associated with the uses of pesticides. This cluster labeling should be complete by the 1986 growing season; if it is not, the need for interim labeling statements will be reconsidered. No labeling statements are currently proposed pertaining to endangered species. 13 ------- Rationale: The Office of Endangered Species of the United States Department of Interior, representatives of agricultural interest groups and the Agency believe the conventional labeling approach is inadequate to properly inform the users on how to protect the endangered species and at the same time use the product to the greatest benefit. It is presently anticipated that appropriate labeling will be developed in time for the 1986 growing season for these five crops. If not, this Standard may be amended to impose interim labeling to protect endangered species which may be affected by use of disul foton. 6. No new uses of disulfoton will be allowed until the the human dietary concerns have been resolved through receipt and analysis of pending toxicology and residue data. Rationale: The Agency is unable to complete a tolerance reassessment because of certain residue chemistry and toxicology data gaps, therefore the Agency cannot propose a change in present tolerances. However the provisional acceptable daily intake (PADI) has been exceeded, and because of this, no 14 ------- new uses for disulfoton will be allowed until the human and environmental concerns raised in this standard have been addressed. (Refer to Section G: Tolerance Reassessment.) 7. The available field and laboratory studies and reports of livestock kills corroborate the Agency’s findings that disulfoton is very highly toxic to fish and highly toxic to birds and rnamn als. The hazard to terrestrial species can result directly from ingestion of granules or indirectly by consumption of invertebrates, vegetation, or water containing disulfoton residues. Available data are not sufficient to assess the significance of this hazard, i.e., to determine if significant population reduction will occur. Full field studies including population monitoring are required. Depending on the results of the environmental fate studies, an avian repro- duction study may be required as well. Depending on the results of the requested metabolism data and the likelihood that the metabolites may be more toxic than disulfoton itself acute toxicity studies of metabolites may be required for mammalian and avian species. 15 ------- For the hazard to fish, additional data are needed before the Agency can complete a full assessment of this hazard potential. Depending on the results of the environmental fate studies full field studies with pbpulation monitoring may be required. A fish early life—cycle study and an aquatic organism accumulation study may also be required depending on the result of lower tier studies and environmental fate data. After the Agency has evaluated these data, it will determine whether EPA should initiate a public interim review process by placing the chemical in Special Review. Rationale: A total risk assessment cannot be made until gaps in the data base for aquatic and terrestrial species and environmental fate are filled. Because exposure data were insufficient to judge the level of concern for disulfoton, the most appropriate regulatory action is to move expeditiously in filling the data gaps. If, after review of these data, regulation of the chemical through the normal regis- tration process is found to be appropriate, the Agency will update its regulatory position and rationale to reflect this conclusion and the reasoning behind it. 16 ------- 8. Manufacturing—uSe and end—use products containing disulfoton must bear revised environmental hazard statements reflecting the pesticide’s toxicity to fish and wildlife (refer to Section F. “Required Labeling). Rationale: Based upon studies available to assess hazards to wildlife and aquatic organisms, disulfoton is characterized as very highly toxic to mammals and aquatic organisms (especially freshwater fish), moderately toxic to highly toxic to birds and moderately toxic to honey bees. updated label precautions required under this Standard should reduce the hazard to fish and other wildlife. 9. The tank mixing of disulfoton with Phosalone for use on pecans and potatoes is prohibited. (Refer to Section F, Required Labeling, for the exact labeling statement.) Rationale: Laboratory potentiation studies with disulfoton and other organophosphate chemicals indicates that the acute toxicity of disulfoton, when mixed with Phosalone and fed to laboratory animals, was enhanced over sixteen times. None of the other tested chemicals potentiated disulfoton’S 17 ------- toxicity. The Agency concludes that this potentiation may occur due to a peculiarity of the Phosalone molecule, but the exact mechanism is unknown. Since the Agency has identified only two uses, (pecans and potatoes) where these two chemicals could be used together, a label prohibition against tank mixing Phosalone and disulfoton for these uses is warranted. 10. Data to evaluate spray drift potential are needed. Those data being required include droplet size spectrum studies and field evaluation of pesticide drift (refer to Table A). Rationale: The Agency is concerned about potential hazards to non—target organisms (domestic animals and humans) from drift after spray applications of disulfoton. This concern is due to the very high toxicity of the chemical to all mammalian species by all routes of exposure (Toxicity Category I). Pesticide Incident Monitoring System (PIMS) incidents lend some support to this concern. Of ten incidents involving domestic animal mortality or morbidity at least three involved deaths to large numbers of horses consuming disulfoton contaminated hay. Of these three incidents one was definitely attributed to spray drift contaminating grazing areas. 18 ------- 11. By this Standard, the Agency is requiring the submission of applications for full registration of all intrastate products containing disulfoton by December 31, 1985 . An “intrastate product is one registered by a State before August 3, 1975, and for which a Notice of Application was filed with the Agency before October 4, 1975. Such products were assigned Accession Numbers by EPA; the latter part of this number, the product number, is greater than or equal to 3000, e.g., 1256—5779. If you have such a product containing disulfoton, you must submit an application for registration including the following information: A. An Application for New Registration (EPA Form 8570—1); B. A complete and accurate Confidential Statement of Formula (EPA Form 8570—4); C. A copy of draft labeling complying with the requirements of 40 CFR 162.10 and this Standard; D. Data required by 40 CFR Part 158 for your product; and 19 ------- E. Information to show your compliance with the requirements of FIFRA sec. 3(c)(l)(D) pertaining to compensation for use of data submitted by another person. (Refer to PR Notice 84—4 for the latest information.) Any distribution or sale of an intrastate (not federally registered) product containing disulfoton after the deadline will be considered to be in violation of FIFRA sec. 12(a)(l)(A). For those intrastate products that are issued a Federal registration, the labeling timeframes set out in section 6 of this Standard (Required Labeling) apply to the product. If you do not wish to pursue Federal registration of your intrastate product, you should request withdrawal of your Notice of Application. If you request withdrawal of your Notice, or if you fail to respond to this notification, you may not distribute or sell the intrastate product after December 31, 1985 . Products already in channels of trade as of that date may continue to be distributed and sold by dealers and retailers until June 30, 1986 Any product found in channels of trade after June 30, 1986 will be considered to be in 20 ------- violation of FIFRA sec. 12(a)(l)(A). Rationale: At the time that the Notice of Application was filed with the Agency, the producer of the intra- state product agreed to submit an application for full Federal registration when directed to do so by the Agency. It is EPA policy that the Agency will require the producer of an intrastate product to submit an application for federal registration if the intrastate product contains the same active ingredient and is intended for the same or a substantially similar end use as federally registered products which are subject to: A. A notice of Rebuttable Presumption Against Registration (RPAR) or Special Review; B. A notice under FIFRA sec. 3(c)(2)(B) requiring the submission of data in support of federal registration; C. A regulation or notice classifying the product for restricted use under FIFRA sec. 3(d)(l)(C); or D. A notice requiring the federal registrant to submit an application for reregistration of his product. 21 ------- Under FIFRA sec. 12(a)(1)(A), it is unlawful for a person in any State to distribute or sell any pesti- cide which is not registered under section 3 [ except as provided by section 6(a)(lfl. 12. Pesticide products containing disulfoton as an active ingredient may be registered for sale, distri- bution, reformulation, and use, subject to the terms and conditions specified in this Standard. Affected registrants must provide (or agree to provide additional in the case of scientific studies) data, labeling and comply with the data compensation provisions of FIFRA sec. 3(c)(1)D. Applicants for new registrations of products containing disulfoton must also comply with these same requirements. Rationale: Under FIFRA, the Agency cannot cancel or withhold registration simply because data are missing or inadequate (see sections 3(c)(2)(B) and 3(c)(7) of the FIFRA). Rather, issuance of this Standard provides a mechanism for identifying data needs. These data will be reviewed and evaluated when they are received and the Agency will determine at that time if they will affect the registration(s) of disulfoton. 22 ------- D. Criteria for Registration under the Standard To be acceptable for registration under this standard, products must contain disulfoton as the sole active ingredient, bear required labeling, and conform to the product composition, acute toxicity limits, and use pattern requirements listed in Section E of this document. The applicant for registration or reregistration of products subject to this Standard must comply with all terms and conditions described in it, including submission of an up—to—date Confidential Statement of Formula, submission of revised labeling, commitment to fill data gaps on the schedule specified by the Agency and, when applicable, offer to pay compensation as required by 3(c)(l)(D) and 3(c)(2)(D) of the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA), as amended, 7 U.S.C. 136(c)(l)(D) and 136(c)(2)(D). Registration applicants must contact the Agency for specific instructions, including updated information on data requirements and companies whose data must be cited and to whom compensation must be offered. E. Acceptable Ranges and Limits 1. product Composition Standard To be covered under this Standard, manufacturing—use products must contain disulfoton as the sole active 23 ------- ingredient. Each MP formulation proposed for registration must be fully described with an appropriate certification of limits, stating maximum and minimum amounts of the active ingredient and any intentionally—added inert ingredients which may be present in products. 2. Acute Toxicity Limits The Agency will consider registration of technical grade and manufacturing—use products containing disulfoton, provided that the product labeling bears appropriate precautionary statements for the acute toxicity category in which each product is placed. 3. Use Patterns To be registered under this Standard, manufacturing— use products containing disulfoton may be labeled for formulation into end—use products only for the commodities listed below. The attached “EPA Index to Pesticide Chemicals” entry lists all registered uses, as well as approved maximum application rates and frequencies. —Terrestrial, non—domestic, food uses on: alfalfa, barley, beans (dry, snap, lima), 24 ------- bermudagrass [ seed crop (24(C)] blackeyed peas (seed crop), broccoli, Brussels sprouts, cabbage, carrots (seed crop), cauliflower, clover, coffee, corn, cotton, garlic (seed crop), hops, lettuce, oats, onion (seed crop), peanuts, peas, pecans, peppers [ 24(C)] pineapple, potato, radish (seed crop), rice, sorghum, soybeans, spinach, strawberries (propagating plants), sugar beets, sugarcane, tomato, turnips (seed crop), and wheat. —Terrestrial, non—domestic, non—food uses on: non—bearing fruit trees (apple, apricot, cherry, crabapple, peach, pear, plum and prune), raspberry (nursery stock), tobacco, ornarnentals (herbaceous plants, woody shrubs, trees) and forest plantings. —Domestic outdoor use on: potted plants, ornamentals (herbaceous plants, flowers, woody shrubs, trees). —Domestic indoor use on: potted plants, ornamentals (specified above). —Greenhouse non—food use on: ornamentals (specified above). 25 ------- F. Required Labeling All manufacturing—use and end—use disulfoton products must bear appropriate labeling as specified in 40 CFR 162.10. This guidance document contains information on label requirements. All labeling changes must appear on all products released for shipment after September 1, 1985 . All labeling changes must appear on all products in channels of trade as of September 1, 1986 . In addition to the above, the following information must appear on the labeling:” 1. Ingredient Statement The ingredient statement for MPs must list the active ingredient as: 0,0—Diethyl S— [ 2—(ethylthio)ethyl] phosphorodithioate....____ 2. Use Pattern Statements All manufacturing—use disulfoton products must state that they are intended for formulation into end—use products for the aforementioned use patterns. Labeling must specify sites, which are listed in Use Patterns , Section E.3. A limiting factor will be data that supports these use patterns. No use may be included on the label where the registrant fails to agree to comply with the data requirements in either Table A or Table B for that use pattern. 26 ------- 3. Precautionary Stat nents Stat nents for Manufacturing—Use Products a. Labels for manufacturing—use disulfoton products must bear statements reflecting the canpound’s acute h .unan toxicity. Disulfoton is in ltxicity Category I by all routes of exposure; the required precautionary stat nts associated with this category are specified in 40 CFR 162.10. b. The following revised environrrental hazard stat nent must appear on all MP labels: “This pesticide is toxic to fish and wildlife. IX not discharge effluent con- taining this active ingredient into lakes, streams, ponds, estuaries, oceans or public waters unless this product is specifically identified and addressed in an NPEES permit. 1X not discharge effluent containing this product to sewer syst ns without previously notifying the sewage treatnEnt plant authority. For guidance contact your State Water Board or Regional Office of the EPA.’ 27 ------- Statements for End—Use Products a. The following “Restricted Use” statement must appear on the label of disulfoton products classified for restricted use: “Restricted Use Pesticide — acute human oral, dermal, and inhalation toxicity” “For retail sale to and use only by certified applicators or persons under their direct supervision and only for those uses covered by the certified applicator’s certification.” b. In the use directions for pecans and potatoes add the following prohibition: “Do not tank mix this product with Phosalone.” C. Add the following worker reentry statement to the labeling of products with directions for use on crops. “Do not allow reentry into treated fields within 24 hours of application unless appropriate protective clothing is worn.” d. Revise the existing environmental hazards statements to read: 28 ------- “This pesticide is toxic to fish and wildlife. Do not apply directly to water or wetlands. Drift and runoff from treated areas may be hazardous to fish in neighboring areas. Do not contaminate water by cleaning of equipment or disposal of wastes. Cover or incorporate spills. This pesticide is toxic to bees exposed to direct application. Applications should be timed to coincide with periods of minimum bee activity, usually between late evening and early morning.” e. Pursuant to PR Notice 83—2, the general worker protection statements specified in that notice must appear on the labeling of outdoor agricultural use products which are applied to crops whose culture requires hand labor. Such products released for shipment after December 31, 1984, must meet the requirements of this PR Notice. f. In the absence of crop rotation data, the crop rotation restriction below must be placed on all products which may be used in a situation where 29 ------- rotation with crops used for food or feed that are not registered with disulfoton may occur: “Do not plant any food or feed crop in rotation after a field treatment with disulfoton unless it is a registered use for disulfoton” C. Tolerance Reassessment U. S. tolerances ranging from 0.1 to 12.00 parts per million (ppm) have been established for the combined residues of disulfoton and its cholinesterase—inhibiting metaboljtes, calculated as demeton* on a variety of raw agricultural commodities (RAC) (40 CFR 180.183) and on the processed feed commodities dried sugarbeet pulp and pineapples bran at 5 ppm (21 CFR 561.160). A summary of the RAC tolerances are presented in Table II located at the end of this section and include Canadian and Codex Maximum Residue Limits. There are no Mexican tolerances for the commodities listed in Table II. The metabolism of disulfoton in plants [ 0,0—diethyl S— [ 2— (ethylthio)ethyl]phosphorodjthjoate (I)] is partially understood. Disulfoton is readily absorbed and translocated by plants. Table I (at the end of this section) depicts the molecular structures of disulfoton and its known metabolites. Identified metabolites included 0,0—diethyl S— [ 2—(ethylsulfinyl) *Demeton (0,0—diethyl 0— [ 2—(ethylthio)ethyl] phosphorothioate is a systemic organophosphate insecticide 30 ------- ethyl]phosphorodjthjoate (II), 0,0—diethyl S— [ 2—(ethylsulfonyl) ethyl]phosphorodithjoate (III), 0,0—diethyl S— [ 2—(ethylsul— finyl)ethyl]phosphorothjoate CV), 0,0—diethyl S— [ 2— (ethylsulfony])ethyljphosphorothjoate (VI), 0,0—diethyl phosphoric acid (VII), 0,0—diethyl phosphorothjoate (VIII), and phosphoric acid (IX). Although not identified in the available metabolism studies, 0,0—diethyl S— [ 2—(ethylthjo) ethyl)phosphorothioate (IV) is a metabolite expected to occur as an intermediate through oxidation; this compound is identical to the demeton thiol isomer and is likely a transient disulfoton intermediary metabolite. Data delineating the quantification of all oxidative metabolites is also required for tolerance reassessment. The Agency is requiring studies of metabolites utilizing ruminants and poultry to determine distribution and characterization of residues in tissues, milk, and eggs as well as an animal metabolism Study (preferably in the rat) to delineate the pharmokinetic and pharrna— codynamic aspects of disulfoton, particularly the rate of conversion of oxidation metaboljtes from one to another. Tolerances are currently expressed in terms of the combined residues of disulfoton and its cholinesterase— 31 ------- inhibiting nietabolites calculated as demeton, which consists of a mixture of the following two isomers: 0,0—diethyl O— [ 2—(ethylthio)ethyl]phosphorothioate and 0,0—diethyl S— [ 2—(ethylthio)ethyl]phosphorothioate. The Agency has determined that it is inappropriate to calculate residues as demeton. Instead, calculation of disulfoton residues as disulfoton sulfone (III) would be more appropriate because: Ci) this compound has the greatest molecular weight of disulfoton and its metabolites (18.6% higher than demeton); (ii) it appears to be a major disulfoton residue in or on plants as a result of treatment whereas demeton thiono isomer is not expected to occur as a disulfoton metabolite; (iii) all analytical methods available involve oxidation to disulfoton sulfone and/or disulfoton 0—analog sulfone and, therefore, even if present, demeton would be oxidized to the corresponding sulfone; and (iv) the Gas Chromatographic (GC) detector response is greater to disulfoton sulfone than to disulfoton 0—analog sulfone. Disulfoton per se (I) is detectable only very soon after treatment of plants. The 0—analog (IV) has not been detected in plants, presumably due to rapid oxidation of the ethylthio sulfur atom of disulfoton or the 0—analog, if formed. Disulfoton sulfone (III) and the 0—analog sulfone (VI) are 32 ------- expected to be the major residues at the time of harvest of treated plants whereas disulfoton sulfoxide (II) and 0—analog sulfoxide (V) will generally be present in lesser quantities. Therefore the current tolerances in 40 CFR 180.183 and 21 CFR must be redefined in terms of disulfoton sulfone. Although plant residues were found to consist almost entirely of oxidation products, the nature and magnitude of the anticholinesterase activity of these individual metabolites were not originally considered in the establishment of existing tolerances. Available studies show certain oxidation products to be more potent cholines— terase inhibitors than the parent compound, and, considering this fact, the actual toxic burden in the diet may be greater than current calculations indicate. The acceptable daily intake (ADI) for cholinesterase inhibition in man is usually determined on the basis of a no—observed—effect—level (NOEL) from a rat chronic feeding study using a normal 10 fold safety factor. However, since the rat chronic feeding study was unaccept- able for setting the ADI, a provisional acceptable daily intake (PADI) for cholinesterase inhibition was established on the basis of a NOEL from a dog chronic feeding study using the customary 10 fold safety factor. 33 ------- A PADI for disulfoton of 0.0025 mg/kg/day was established using a NOEL of 1.0 ppm (0.025 mg/kg) and the maximum permissible intake (MPI) for a 60 kg person is 0.1500 mg/day. Toxicological studies are needed to establish acceptable metabolites. The use of a PADI of 0.0025 mg/kg/day replaces the previous ADI of 0.005 mg/kg/day and may accomodate the uncertainty surrounding greater toxicity and serve to alleviate dietary concerns in the interim between issuance of this Standard and the time the Agency receives and analyzes the metabolite data. The theoretical maximum residue contribution (TMRC) to the human diet from existing tolerances is 0.2544 mg/day (in 1.5 kg of human diet) and represents 169.59% of the PADI. However, a reassessment of the current tolerances based on actual constituents of the plant residues is necessary and additional residue data are needed to determine the nature and magnitude of human dietary exposure to disulfoton’s metabolites. Although the Agency is concerned about exceeding the PADI no regulatory action is warranted now pending receipt of metabolite toxicity and residue chemistry 34 ------- data with which to evaluate the magnitude of human dietary exposure to disulfoton and its metabolites. The Agency believes, for several reasons, that the public will be in no inunediate danger while awaiting exposure assessment data. The TMRC assumes that 100 percent of the crop for which a tolerance is established is treated with disulfoton. Disulfoton’s major uses are cotton, sorghum, and wheat, and the estimated percentage of disulfoton’s use on these crops is low. When adjustments are made for the estimated percentage of crops treated with disulfoton, The Agency assumes the ratio between residue contribution and the PADI is actually much lower than 169%. The Agency recognizes that the statistical significance of the Food and Drug Administration’s market basket survey is limited, but results from this monitoring can function as an indicator of immediate dietary exposure risks. Monitoring activity for the past several years shows that although present, disulfoton residues are consistently below established tolerances, which further alleviates the Agency’s immediate concern over disulfoton’s use while collecting data for a tolerance reassessment. The Agency is requesting data pertinent to the 35 ------- reassessment of current tolerances on an accelerated basis as indicated in Table A. Additional residue data required to support existing tolerances for disulfoton residues in or on certain commodities are listed in Table A. The Agency is also requesting that certain additional tolerances be proposed for certain agricultural commodities and feed/food items. No new crop groupings can be established at this time because of extensive residue chemistry data gaps. Compatibility between Codex MRL’s and U.S tolerances will be assessed when data specified in Table A have been submitted and evaluated. Because the Agency is concerned about the magnitude of the metabolites’ toxicity and their effect on the dietary assessment for disulfoton, and considering the fact that certain food processing techniques could increase the dietary exposure through enhanced oxidation, the Agency may request post—processing residue data be submitted after the above—noted residue data have been submitted and evaluated. 36 ------- Table 1. Disulfotori and its rnetabolites. Code Structure Ch 1ca1 5 O,G-dlet*yl S—C2—(ethylthlo)ethyt]phosphoroditl.loate 1s 1fot n (co)z sc izcI12sc2Hs i i 0 O.O-dlethyl S—C2—(ethy sul finy )etflyl ]phosphorodltMo.te Dl sul toWn (c so)zPsc as2 c 5 sulfoxide Lu o 0,0—diethyl S42—(sthylsulfonyl )et1ly1]pI sphorod1th1oate Disulfoton H II sulfon. (c 2 Hso)zPscHta’42sc2u5 Iv a 0,0—diethyl S—(2—(ethyl thlo )ethyl ]pnospt rothioat* Olsul foton ii O —ana og (C 2 HSO) 2 PSCH2*12 5C2H5 v o 0,0—disthyl S-(2—(ethy suIfVnyL)eUIy1]pnosphorotMoate D1 u1foton II II O- .naloç (CZf., 0) 2 PSOi O1 2 SCZH5 sulfoxide 0 0 O.O—dletflyi S—(2.(ethyl uI fotlyl ) .thyl ]phospnorctfllo.te Dl sulfoton II II O-.n .Iog (c 2 H 5 o) 2 Psc,l 2 cH 2 sc 2 s-i 5 sulfone 0 v i i O,D—dlethyi p soIsoric acid Oletnyl PfloS- II D i late (c 2 M 5 o) 2 e 0H VIII 0 O ,G-diethyl Dilouflorothlcate Oletilyl phos- II pl lOrOtMObte (c o) ps PI sphor1c acid 37 ------- TABLE II SUMMARY OF PRESENT TOLERANCES Commodity alfalfa (fresh) alfalfa (hay) asparagus barley (fodder,green) barley (grain) barley (straw) beans (dry) beans (lima) beans (snap) beans (vines) beets, sugar (roots) beets, sugar (tops) broccol i brussels sprouts cabbage cauliflower clover (fresh) clover (hay) coffee beans corn, field (fodder) corn, field (forage) corn, (grain) corn, pop corn, pop (fodder) corn, pop (forage) corn, sweet (fodder) corn, sweet (forage) corn, sweet, grain (kernels plus cob with husks removed) cottonseed hops lettuce oats (fodder, green) oats (grain) oats (straw) peanuts peanuts (hay) peanuts (hull) peas peas (vines) Tolerances (ppm) U.S.(a) Canada Codex (MRL)(b) 5.0 12.0 0.1 5.0 0.75 5.0 0.75 0.75 0.75 5.0 0.5 2.0 0.75 0.75 0.75 0.75 5.0 12.0 0.3 5.0 5.0 0.3 0.3 5.0 5.0 5.0 5.0 0.3 0.75 0.5 0.75 5.0 0.75 5.0 0.75 5.0 0.3 0.75 5.0 10.0 0.5(c) 5.0(d) 0.2(f) 0.5(c) 0.5(c) 0.5(c) 0.5 0.5(c) 0.5(c) 0.5(c) 0.5(c) 10.0 0.1 0.5(e) 0.5(e) 0.5(e) 0.5(e) 0.5(e) 0.5(e) 0.5(e) 0.5(e) 0.5 0.5 0.5 0.5 0.5 0.5 0.5 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 per per per per per per per per per per per per per se se se se se se se se se se se se se se se 0.1 per se 0.5(e) 0.5 P! se 0.5(c) 0.2(f) 0.1(a) 0.5 per se 0.5(c) 38 ------- Commodity pecans peppers pineapples pineapples (forage) potatoes rice rice (straw) sorghum (fodder) sorghum (forage) sorghum (grain) soybeans soybeans (forage) soybeans (hay) spinach sugarcane tomatoes wheat (fodder, green) wheat (grain) wheat (straw) TABLE II (cont.) SUMMARY OF PRESENT TOLERANCES 0.75 0.1 0.75 5.0 0.75 0.75 5.0 5.0 5.0 0.75 0.1 0.25 0.25 0.75 0.3 0.75 5.0 0.3 5.0 0.1 0.5(c) 0.1 0.5 0.5(h) 5.0(d) 5.0(d) 0.2(f) 0.1 (a) Disulfoton and its cholinesterase inhibitin metabolites, calculated as demetori (b) Additive residues of disulfoton, demetori—S, and their sulfoxides and sulfones, expressed as disulfoton (c) In or on vegetables (d) In or on all green forage crops (e) In or on maize (f) In or on all cereal grains (g) Kernels only (h) In or on rice in the husk Tolerances (ppm) U.S.(a) Canada Codex (MRL)(b) 0.1 per . ! 0.2 2 0.5 per . ! 0.5(c) 0.5 per . ! 0.5(c) 0.2(f) Footnotes for Table II 39 ------- EPA Index to Pesticide Chemicals 0,0—DIETHYL S- [ 2—(ETUYLThIO)EThYLI PHOSPHORODITHIOATE TABLE OF CONTENTS AGRICULTURAL CROPS Alfalfa 2 Apple (nonbearing) 3 Apricot (nonbearing) 3 Barley 4 Beans, Dry 4 Beans, Liina 4 Beans, Snap 4 Bermudagrass (seed crop) 5 Blackeyed Peas (seed crop) 5 Broccoli 5 Broccoli (transplant beds) 6 Brussels Sprouts - 6 Brussels Sprouts (transplant beds) 6 Cabbage 7 Cabbage (transplant beds) 6 Carrots (seed crop) 7 Cauliflower 8 Cauliflower (transplant beds) 6 Cherry (nonbearing) 3 Clover 8 Clover (seed crop) 8 Coffee 9 Corn 9 Cotton 10 Crabapple (nonbearing) 3 Issued: 5—11—82 111—032501—i ------- EPA Index to Pesticide Chemicals 0 ,O-DIETHYL S- [ 2-( ETHYLTHIO) ETHYL] PHOSPHOROD ITHIOATE TABLE OF CONTENTS Garlic (seed crop) 7 Hops 12 Lettuce 13 Oats 13 Onion (seed crop) 7 Peach (nonbearing) 3 Peanuts 14 Pear (nonbearing) 3 Peas 15 Pecan 15 Peppers 16 Pineapple 16 Plum (nonbearing) 3 Potato 17 Prune (nonbearing) 3 Radish (seed crop) 7 Raspberry (nursery stock) 18 Rice 18 Sorghum 19 Soybeans 20 Soybeans (seed crop) 21 Spinach 21 Strawberries (propagating plants) 21 Sugar Beets 22 Sugarcane 22 Tobacco 23 Issued: 5—11—82 111—032501—il ------- EPA Index to Pesticide Chemicals 0 ,O—DIETHYL S— [ 2—(ETHYLTHIO)ETHYL] PHOSPHDRODITHIOATE TABLE OF CONTENTS Tobacco (transplant beds) 23 Tomato 24 Tomato (transplant beds) 25 Turnips (seed crop) 7 Wheat 26 ORNAZIENTALS ( Ornamental Plants (herbaceous, woody shrubs, trees and vines) ) Ornamental Herbaceous Plants 27 Ornamental Trees 28 Ornamental Trees (nursery stock) 29 Ornamental Woody Shrubs 28 Ornamental Woody Shrubs (nursery stock) 29 ( Ornamental Houseplants ) Ornamental Herbaceous Plants (houseplants) 30 FOREST, CHAPARRAL, NONAGRICULTURAL AND WASTELANDS Forest Plantings 30 AERIAL, MOThPROOFING AND TANK MIX APPLICATIONS Aerial Application 30 Issued: 5—11—82 111—032501—ui ------- EPA Index to Pesticide Chemicals c032501 0,0—DIETHYL S— [ 2-(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE* TYPE PESTICIDE : Insecticide, Acaricide FORMULATIONS : Tech (95%) Fl (2%, 2.2%, 5%, 68%) G (0.25%, 0.28%, 0.33%, 0.4%, 0.5%, 0.625%, 0.67%, 0.75%, 0.8%, 0.99%, 1%, 1.33%, 2%, 5%, 10%, 15%) PIT (2%) EC (6 lb/gal, 8 lb/gal) RTU (95%) GENERAL WARNINGS AND LIMITATIONS : The following formulations are RESTRICTED USE PESTICIDES: Emulsifiable concentrates — All emulsifiable concentrates 65 percent and greater, all emulsifiable concentrates and concentrate solutions 21 per- cent and greater with fensulfothion 43 percent and greater, all emulsifi- able concentrates 32 percent and greater in combination with 32 percent fensulfothion and greater. Liquid—ready to use — 95 percent and greater Granular — 2 percent and greater (for use in greenhouses) The use of granular formulations greater than 2 percent are limited to commercial applicators. Do not apply with a knapsack or other equipment that is placed on the user’s body. Disulfoton is toxic to fish and wildlife. Do not apply directly to water or wetlands. Drift and runoff from treated areas may be hazardous to fish in neighboring areas. Do not contaminate water by cleaning of equipment or disposal of wastes. Cover or incorporate spills. Bee Caution : Disulfoton is toxic to bees exposed to direct application. Applications should be timed to coincide with periods of minimum bee activity, usually between late evening and early morning. Agricultural Crop Tolerances : Peppers — 0.1 ppm Definition of Terms : Claims for pest control limited to suppression of populations are indicat- ed by parenthesized pest name. *Djsul foton Di—Syston Issued: 5—11—82 1 1 1—032501—i Provisional Update: 12—05—84 ------- EPA Index to Pesticide Chemicals 0, 0-DIETHYL s- [ 2-(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE Site and Pest Dosages and Tolerance, Use, Limitations Formulation(s) AGRICULTURAL CROPS General Warnings and Limitations : On row crops where row spacing is extremely narrow, do not place treated zones (band or furrow) closer together than 6 inches. Do not reenter treated fields within 24 hours of application. If reentry prior to 24 hours is required, appropriate protective clothing must be worn. Do not plant any crop used for food or feed in disulfoton treated soils other than those with registered disulfoton uses. Plant Response Precaution : When used on beans, cotton, lett:uce, sugar beets, or tomatoes at the maximum recommended rates under adverse condi- tions such as extremely cool or wet or extremely dry weather disulfotort may cause some delay in emergence, stunting of seedlings, or reduction of stand. Damage may be more pronounced in light, sandy soils. Emulsifiable concentrate formulations : Apply in a water emulsion or with liquid fertilizer. When mixing with certain high phosphorous fertilizers an anionic water soluble adjuvant may be needed. Unless otherwise speci- fied, apply per acre races in a minimum of 1 gallon of water per acre by aircraft or ground equipment. Unless otherwise specified, per 1,000 foot row dosages are applied as a soil injection. Low volume soil injection equipment may be used when applying more than 1 quart (6 or 8 pounds per gallon) liquid per acre. Granular formulations : Broadcast foliar applications may be applied by aircraft. Resistance to disulfoton : Due to greenbug resistance in certain areas within the high plains of TX, eastern NM, the OK panhandle, eastern CO, western KS, and SD, disulfoton used alone may not provide satisfactory control. Consult state cooperative extension service for additional information. /23001AA Alfalfa 5 ppm (fresh alfalfa) 12 ppm (alfalfa hay) No preharvest or pregrazing interval through 1 pound per acre for broad- cast application. Allow a minimum of 28 days between applications. IRACAAA Aphids 1 lb/A Broadcast application at planting, ILAAABA Mites (0.25—15% G) prior to growth in the spring, or during the growing season. 1 lb/A Broadcast application. Apply in (6 lb/gal EC) early spring prior to growth or to the stubble after the alfalfa has been cut and removed from the field. Do not apply to alfalfa foliage. Issued: 5—11—82 111—032501—2 ------- EPA Index to Pesticide Chemicals 0 ,0—DIETHYL. S— [ 2—(ETUYLTHI0)ET1IYLJ PHOSPHORODITRIOATE Site and Pest Dosages and Tolerance, Use, Limitations Formulationl .s ) /2300 1BA Alfalfa (seed crop) 12 ppm (alfalfa hay) Chaff and hulls from treated seed crop may be used for feed, however, do not use green chop for feed or forage. 14 day preharvest interval through 1 pound per acre for foliar applica- tion to seed crop. Do not make more than 4 applications during the growing season. £RACAIA Pea aphid 0.5—1 lb/A Foliar application to seed crop. (6—8 lb/gal EC) /O4001DA Apple (nonbearing) N.F. IO500IDA Apricot (nonbearing) Do not apply to trees that will bear /05002DA Cherry (nonbearing) fruit during current crop year. /04002DA Crabapple (nonbearing) /05004DA Peach (nonbearing) /04003DA Pear (nonbearing) /05005DA Plum (nonbearing) /05006DA Prune (nonbearing) IRACAAA Aphids 0.375—4.05 Soil application to nonbearing IQAXAAA Lace bug oz/tree stock. Apply uniformly from trunk IRAFAAA Leafhoppers or to drip line on all sides. Incor— ILAAABA Mites 0.375—0.4 oz/ porate into soil and water thorough— IMOAAAA Thrips in. of trunk iy. Apply the higher per tree dos— £RABAA.A Whiteflies diameter age for heavy organic or muck soils. (5—15% G) Soil application to nonbearing stock at transplanting. Apply equivalent amount to planting hole. Apricot See Apple (noribearing) cluster. Issued: 5—11—82 111—032501—3 ------- EPA Index to Pesticide Chemicals 0, 0—DIETHYL S—(2—(EThYLTHIO)ETHYL] PHOSPHORODITHIOATE Site and Pest Dosages and Formulation(s ) Tolerance, Use, Limitations 0.75 ppm (grain) 5 ppm (green fodder and straw) 60 day preharvest interval (grain) through 1 pound per acre for foliar application. 30 day pregrazing or preharvest interval (forage, fodder) through I pound per acre for foliar applica— t ion. Do not during method make more than 2 applications crop season regardless of of application. Foliar application. Apply lover rate on plants up to tillering (stooling) and higher rates on plants after tillering. For appli- cation in liquid fertilizer, apply as a topdress by ground equipment. Observe resistance statement. Refer to Oats for additional information. 0.75 ppm (beans: dry, lime, snap) 5 ppm (bean vines) 60 day preharvest interval through 1.9 ounces per 1,000 feet of row for soil application. Do not make more than 1 application during the grow- ing season. For extremely narrow row spacing, do not apply more than 2 pounds per acre. Observe plant response pre- caution. IRACAAA tRAP A.AA INAPAFC IIAAABA IMOAAAA Aphids Leafhoppers Mexican bean beetle (larvae) Mites Thrips 0.9—1.9 oz/ 1,000 ft row (0.4—15% G) (6—8 lb/gal EC) or 0.01—0.018 oz /10 ft row (1—2% C) /28063AA Barley IP..ACDNA Greenbug 0.5—1 lb/A (6—8 lb/gal EC) Beans, Dry Beans, Lime Beans, Snap /1500 IAA / 15002AA /I50 03AA Soil application at planting (double band). Apply a band on each side of the furrow. Do not apply directly on the seed. Issued: 5—11—82 111—032501—4 ------- EPA Index to Pesticide Chemicals 0, 0-DIETHYL S- [ 2-(ETHYLTHIO)ETHYU PHOSPHORODITHIOATE Site and Pest Dosages and Formulation(s ) Tolerance, Use, Limitations Beans, Dry cluster (continued) .1 1500 IAA IRACAAA RAFAAA INAPAFC ILAAABA IMOAAAA (Beans, Dry) Aphids Leafhoppers Mexican bean beetle (larvae) Mites Thrips 0.9—1.9 oz/ 1,000 ft row (0.4—15% G) (6—8 lb/gal EC) or 0.01—0.018 oz /10 ft row (1—2% G) /15008BA Blackeyed Peas (seed crop) Crowder Peas (seed crop) Southern Peas (seed crop) or 0.01 oz/l0 row (1—2% C) This use only occurs on 24(c) Spe- cial Local Need labeling and has not been included in this entry. Refer to appropriate labeling for use in— format ion. N.F. Soil application at planting (double band). Apply band on each side of seed furrow. Do not apply directly on the seed. OR Postemergent soil application (band). Apply as a sidedress after plants are established. 0.75 ppm 14 day preharvest interval through 1.125 ounces per 1,000 feet of row for soil application. Do not apply more than I application during the growing season. Soil application at planting (double band). Apply band on each side of the furrow or transplant row. Do not apply directly to seed. OR Postemergent soil application ft (band). Apply as a sidedress after plants are established. Postemergent soil application (double band). Apply as a sidedress on each side of the row after plants are established. /22017BA Bermudagrass (seed crop) IRACAAA Aphids 0.6—1.2 oz/ IRAFAAA Leafhoppers 1,000 ft row ILAAABA Mites (5% G) IMOAAAA Thrips /13005AA Broccoli IRACAAA Aphids 1.1—1.125 oz/ INANADA Flea beatles 1,000 ft row IRAFAAA Leafhoppers (0.25—15% C) ILAAABA Mites (6—8 lb/gal IM OAAAA Thrips EC) Issued: 5—11—82 111—032501—5 ------- EPA Index to Pesticide Chemicals 0, 0—DIETHYL S— [ 2-(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE Site and Pest Dosages and Formulation(s ) Tolerance, Use, Limitations Broccoli (continued) IRACMA INAMADA IRAFAAA ILAAABA IMOAAAA /13006AA Brussels Sprouts 2 tsp 1% G or 1 tsp 2% Cl plant (1—2% G) 0.92 oz/2,500 sq. ft (5—15% G) (6—8 lb/gal EC) or 0.01 oz/lO ft row (1—2% C) Soil application at planting. Mix with soil in transplant hole before setting Out plants. 0.75 ppm Broadcast soil application to trans- plant beds through 0.92 ounce per 2,500 square feet. Do not make more than I application. 0.75 ppm 30 day preharvest interval through 1.125 ounces per 1,000 feet of row for soil application. Do not make more than 2 applications during the growing season. t Allow a minimum of 21 days between appUca— tions. Soil application at planting (double band). Apply band on each side of the furrow or transplant row. Do not apply directly to the seed. OR Postemergent soil application (band). Apply as a sidedress after plants are established. 2 tsp 1% C or 1 tsp 2% Gf plant (1—2% C) Soil application at planting. Mix with soil in transplant hole before setting Out plants. Brussels Sprouts (transplant beds) See Broccoli (transplant beds) cluster. /I3005DA / 13006DA /I3007DA / 13008DA Broccoli (transplant beds) Brussels Sprouts (transplant beds) Cabbage (transplant beds) Cauliflower (transplant beds) Aphids Flea beetles Lea fhoppers Mites Thr i PS Preplant broadcast soil application to transplant beds. Incorporate into top 2 to 3 inches of soil. OR Postemergent broadcast soil applica- tion to transplant beds. Apply granular over plants after emer- gence. Water thoroughly. IRACAAA Aphids 1.1—1.125 oz/ INAMADA Flea beatles 1,000 ft row IRAFAAA Leafboppers (0.25—15% C) ILAAABA Mites (6—8 lb/gal IMOAAAA Thrips EC) Issued: 5—11—82 111—032501—6 ------- EPA Index to Pesticide Chemicals 0, 0-DIETHYL S- [ 2-(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE Site and Pest Dosages and Formulation(s ) Tolerance, Use, Limitations 0.75 ppm 42 day preharvest interval through 1.7 ounces per 1,000 feet of row for soil application. Do not make more than 2 applications during the growing season. Allow a minimum of 21 days between applica- tions. IRACABA Root aphids 1.1—1.125 oz/ 1,000 ft row (0.25—15% G) (6—8 lb/gal EC) or 0.01 oz/l0 ft row (1—2% G) 1.7 oz/1,000 ft row (0.25—15% C) (6—8 lb/gal EC) Soil application at planting (double band). Apply band on each side of the furrow or transplant row. Do not apply directly to seed. OR Postemergent soil application (band). Apply as a sidedress after plants are established. Cabbage (transplant beds) Aphids Lea fhoppers Mites Th rips 2 tsp 1% C or I tsp 2% G/ plant (1—2% G) Soil application at planting. Mix with soil in transplant hole before setting out plants. See Broccoli (transplant beds) cluster. Soil application at planting (double band). Apply band on each side of seed furrow. Do not apply directly on the seed. OR Postemergent soil application. Apply by broadcast or as a sidedress after plants are established. / 13007AA Cabbage IR.ACAAA tNANADA Aphids Flea beetles Aphids Flea beetles IRACAAA INANADA /28073BA /14007BA / 14011 BA /140 14BA / 28002 BA IRACAAA I RAFA.AA ILAAABA IMOAAAA Carrots (seed crop) Garlic (seed crop) Onion (seed crop) Radish (seed crop) Turnips (seed crop) N.F. 0.3—0.55 oz/ 1,000 ft row (5% C) Issued: 5—11—82 111—032501—7 ------- EPA Index to Pesticide Chemicals 0, 0—DIETHYL S— [ 2—(ETHYLTHIO)EThYLJ PHOSPHORODITHIOATE / 13008AA Site and Pest Cauliflower Dosages and Formulation(s ) 1.1—1.125 oz/ 1,000 ft row (0.25—15% G) (6—8 lb/gal EC) or 0.01 oz/lO row (1—2% C) Tolerance, Use, Limitations 0.75 ppm 40 day preharvest interval through 1.125 ounces per 1,000 feet of row for soil application. Do not make more than 2 applications during the growing season. Allow a minimum of 21 days between applica— t ions. Soil application at planting (double band). Apply band on each side of the furrow or transplant row. Do not apply directly to seed. OR Postemergent soil application ft (band). Apply as a sidedress after plants are established. 2 tsp 1% C or 1 tsp 2% G/ plant (1—2% G) Soil application at planting. Mix with soil in transplant hole before setting out plants. 5 ppm (fresh clover) 12 ppm (clover hay) 7 day preharvest or pregrazing interval through 1 pound per acre for broadcast soil application. Allow a minimum of 28 days between applications. N.F. Allow a minimum of 21 days between applications. IRACAAA INAMADA IRAFA.AA Aphids Flea beetles Leafhoppers Cauliflower (transplant beds) Cherry (nonbearing) /23003AA Clover See Broccoli (transplant beds) cluster. See Apple (nonbearing) cluster. IR.ACAAA ILAAABA Aphids Mites /23003BA Clover (seed crop) IRACAAA ILAAABA Broadcast soil application. Repeat as needed. I lb/A (5—15% C) 1.5 lb/A (5—15% G) Aphids Mites Broadcast soil application. Repeat as needed. Issued: 5—11—82 111—032501—8 ------- EPA Index to Pesticide Chemicals 0, 0-DIETHYL S- [ 2-(ETHYLTUIO)ETHYL] PHOSPHORODITHIOATE /07002AA Site and Pest Coffee Dosages and Formulation(s ) Tolerance, Use, Limitations 0.3 ppm 90 day preharvest interval through 0.6 gram per foot of tree height. Make no more than 1 pre— and 1 pos t— harvest soil application. Do not make more than 2 applications dur- ing the year. INAAAGA Lea fminers 0.3—0.6 g/ft of tree height c 5—l5Z G) Use limited to PR. Pre— and/or postharVest soil appli- cation. Apply uniformly under tree canopy. Aphids Mites Corn rootworms (adults) 0.3 ppm (grain including field corn and sweet corn (kernels plus cob with husk removed), popcorn) 5 ppm (fodder and forage (including field corn, sweet corn, and pop- corn)) 28 day preharvest interval for emulsifiable concentrate formula- tions through 1 pound per acre for foliar application. 40 day preharvest interval for granular formulations through 1.2 ounces for 1,000 feet of row for soil application. Do not make more than 2 applica- tions per season. Apply 1 foliar and 1 soil application per crop season. Foliar application. For corn root— worm adults apply when there is an average of 3 to 5 beetles per plant. INAMBHA Corn rootworms 1.2 oz/1,000 ft row (0.4—15% G) (6—8 lb/gal EC) Soil application at planting (band). Apply a 4 to 6 inch band directly behind the planter shoe in front of the press wheel. Emulsifiable con- centrates applied with liquid fer- tilizer apply split bands on each side of the row. A second applica- tion may be applied to the soil as sidedress treatment later in the season. Do not apply directly to the seed. /28005AA Corn IR.ACAAA ILAAABA INANBHJ 0.5—1 lb/A (6—8 lb/gal EC) Issued: 5—11—82 111—032501—9 ------- EPA Index to Pesticide Chemicals 0,0-DIETHYL S— [ 2—(ETHYLThIO)ETUYLI PHOSPHORODITHIOATE IRACAAA INANBHA IRAFAAA ILAAABA IMOAAAA IRACAAA IRAFAAA ILAAABA IMOAAAA Corn (continued) Aphids Corn rootworms Lea fhoppers Mites Thrips Aphids Lea fhoppers Mites Thr p5 sand Formulation(s ) 1.2 oz/l,000 ft row (l—15Z C) (6—8 lb/gal EC) 1.2 oz/l,000 ft row (5—15% C) 0.75 ppm (cottonseed) 90 day preharvest interval (or up to first squaring) through 2.4 ounces per 1,000 feet of row for soil application. 28 day preharvest interval through 1.2 ounces per 1,000 feet of row for soil application. Do not make more than 2 postemer- gent soil applications during the crop season. Allow a minimum of 21 days between postemergent soil applications. Foliar application prior to bloom through 9 ounces per acre. Do not make more than 3 foliar ap- plications during the crop season. If foliar applications are made do not make soil applications within the same crop year. Observe plant response precaution. 0.75—1.2 oz/ 1,000 ft row (6—8 lb/gal EC) 0.7—1.2 oz/ 1,000 ft row (0.25—15% C) (6—8 lb/gal EC) Preplant soil application (band). Apply a 16 inch band in a water emulsion or with a preemergent herbicide. Incorporate into soil. OR Soil application at planting (band). Apply granular in or on both sides of the furrow. Spray emulsifiable concentrate on either side of the seed or inject on each side of the furrow. OR Site and Pest Tolerance, Use, Limitations Postemergent soil application (band). Apply granular formulation as a sidedress and emulsifiable con- centrate on each side of the furrow. Foliar application. Broadcast into the whorl. /28007AA Cotton IRACAAA IL .AAABA IMOAAAA Aphids Mites Thrips Issued: 5—11—82 111—032501—10 ------- EPA Index to Pesticide Chemicals 0, O—D IETHYL s— [ 2—( ETHYLTHIO) ETHYL] PHOSPHORODITHIOATE Site and Pest Dosages and Formulation(s ) Tolerance, Use, Limitations Cotton (continued) 1.2—2.4 oz/ 1,000 ft row (5—15% C) (6—8 lb/gal EC) Poatemergent soil application. Apply in addition to at planting if needed. Apply granular as a side— dress or broadcast over the foliage. Inject emulsifiable concentrate on each side of the row. Allow a mini- mum of 21 days between applications. Apply preplant at planting and post— emergent treatments as follows: Light soils — 0.7 to 0.75 ounce per 1,000 feet of row. Medium soils — 1 ounce per 1,000 feet of row. Heavy soils — 1.2 ounces per 1,000 feet of row. OR Postemergent soil application. Use of granular formulations is limited to irrigated cotton. Apply up to first squaring (90 days before har- vest). Apply in addition to at planting application if needed. Apply granular as a sidedress or broadcast over the foliage. Ap- ply emulsifiable concentrate on each side of the row. Apply the lower dosage rate for light soils andthe higher rate for heavy soils. 0.375—0.5 oz/ 1,000 ft row (15% G) Soil application to hill dropped cotton at planting (band). Apply with seed at planting. Apply lower rate when hill spacing is greater than 14 inches in the row or where applications are made to light, sandy soils. Foliar application prior to bloom. Repeat as needed. IRACAAN LMOAAAR Aphids Thrips 3—9 oz/A (6—8 lb/gal EC) Issued: 5—11—82 1 1 1—03250 1— Il ------- EPA Index to Pesticide Chemicals 0,0—DIETHYL S-(2—(ETHYLTUIO)ETHYL] PHOSPHORODITHIOATE Site and Pest Dosages and Tolerance, Use, Limitations Formulation(s) Cotton (continued) IRACAAA Aphids 4—8 oz/lOO lb Seed treatment. Apply ready to use IMOAAAA Thrips 8eed with seed treating equipment. Apply (9.14 lb/gal uniformly to cover all seeds. For RTU) control of early season aphids and thrips. For reduction of mites ILAAABA (Mites) 8 oz/lOO lb during the critical period from seed emergence to the 4 to 6 leaf stage. (9.14 lb/gal If the low rate is used, control RTU) may be impaired if treated seed is carried over to the next growing season. Repeat treatment using the low rate the following season to ensure maximum insect control. Properly label treated seed. Treat- ed seeds exposed to soil surface will be hazardous to birds and wild- life. Crabapple (nonbearing) See Apple (nonbearing) cluster. Garlic (seed crop) See Carrots (seed crop) cluster. /08020AA Hops - 0.5 ppm Soil application through 4 pounds per acre or 0.072 ounce per plant for standard 7 foot by 7 foot hopyard spacing. Do not graze or feed crop refuse to livestock. IRACAAA Aphids 2—4 lb/A Soil application. Apply in a 6 inch ILAAABA Mites OR square at the base of each plant. 0.036—0.072 Apply mid to late June just prior oz/plant to the hilling. Hilling operation [ 7 ft by should cover granules with soil. 7 ft hopyard Irrigate as normal crop culture re— spacing] quires. (15% G) Issued: 5—11—82 111—032501—12 ------- EPA Index to Pesticide Chemicals 0,0-DIETHYL S-E2—(ETHYLTHIO)ETHYL PHOSPHORODITHIOATE Site and Pest Dosages and Formulation(s ) Tolerance, Use, Limitations /28062AA Oats /28063AA 0.56—1.2 oz/ 1,000 ft row (0.25—15% G) (.6—8 lb/gal EC) or 0.008—0.012 oz/l0 ft row (1—2% C) 0.75 ppm 60 day preharvest interval through 1.2 ounces per 1,000 feet of row for soil application. Do not apply to transplanted let- tuce. Observe plant response pre- caution. Soil application to spring or sum- mer seeded lettuce at planting (dou- ble band). Apply band on each side of furrow. Do not apply directly on seed. Apply higher rate on heavy organic soils. Postemergent soil application to fall or winter seeded lettuce (band). Apply as a sidedressing at thinning time. 0.75 ppm (grain) 5 ppm (green fodder and straw) 60 day preharvest interval (grain) through 1 pound per acre for soil application. 30 day pregrazing or preharvest interval (forage, fodder) through I pound per acre for soil application. Do not apply more than 2 times er crop season. Allow a minimum of 21 days between postemergent soil ap- plications. Observe resistance statement. Soil application at planting. Apply as a soil injection. /13020AA Lettuce IRACAAA Aphids IR.AFAAA Leafhoppers LAAABA Mites IMOAAAA Thrips Aphids Mites Onion (seed crop) Peach (nonbearing) .RACAAA ILAAABA I lb/A (0.4—15% G) 1 lb/A (6—8 lb/gal EC) Soil application at planting by broadcast or drilling. OR Postemergent broadcast soil appli- cation. See Carrots (seed crop) cluster. See Apple (nonbearing) cluster. Issued: 5—11—82 tiI—03250 1—13 ------- EPA Index to Pesticide Chemicals 0,0-DIETHYL S— [ 2—(ETHYLTHIO)ETRYL] PHOSPHORODIThIOATE Site and Pest Dosages and Tolerance, Use, Limitations Formulation(s ) _______ 0.75 ppm (peanuts) 0.3 ppm (peanut hulls) 5 ppm (peanut hay) Broadcast soil application (prep— lant) through 6 pounds per acre. Do not make more than 1 broadcast soil application during the growing season. Banded soil application (at pegging) through 2.25 ounces per 1,000 feet of row. Do not tank mix with phosalone. Preplant broadcast soil application. Incorporate to a depth of 3 to 6 in- ches by disc or other suitable equipment. Soil application at planting (double band). Apply on each side of the seed furrow. Do not apply directly on the seed. Postemergent soil application (side— dress). Apply after plants are established. Soil application at pegging. Apply if needed. Pear (nonbearing) See Apple (nonbearing) cluster. /28015AA Peanuts IMOAAAA IRACAAA IRAFAAA ILAA.ABA IMOAAAA Thrips 6 lb/A (6—8 lb/gal EC) Aphids Leafhoppers Mites Thrips 1.1—2.25 oz/ 1,000 ft row (l.33—l5 C) (6—8 lb/gal EC) OR OR Issued: 5—11—82 111—032501—14 ------- EPA Index to Pesticide Chemicals 0, O-D IETHYL S- [ 2—( ETHYLTHIO) ETHYL] PHOSPHORODITHIOATE Site and Pest Dosages and Tolerance, Use, Limitations Formulation(s ) /28075AA Peas 0.75 ppm 5 ppm (pea vines) 50 day preharvest interval through 2.5 pounds per acre. Do not make more than 1 application during the growing season. IRACAAA Aphids 1—2.5 lb/A Soil application at planting. IRAFAAA Leafhoppers (0.5—15% C) Apply granular by drilling or (6—8 lb/gal broadcasting. Apply emulsifiable EC) concentrate as an in furrow spray or as an injection on each side of the furrow. OR Postemergent soil application (band). Apply as a sidedress after plants are established. 0.01% oz/lO Soil application at planting (double ft row band). Apply band on each side of (1—2% G) furrow. /03008AA Pecan 0.75 ppm 80 day preharvest interval through 3 pounds per acre for soil applica- tion. Do not make more than 1 soil application during the growing season. 30 day preharvest interval throUgh 1.5 pounds per acre for foliar application. Do not make more than 3 foliar applications during the growing season. Do not allow livestock to graze under treated trees. Do not tank mix with phosalone. IRACAAA Aphids 1—3 lb/A Use limited to central and south— (15% C) western states. (6—8 lb/gal Soil application (double band). Ap— EC) ply 6 foot bands on both sides of trees under the main drip area. In- corporate into the upper 2 to 3 in- ches of soil. For irrigated pecans apply water as soon as possible af- ter treatment. Apply in early spring. Issued: 5—11—82 111—032501—15 ------- EPA Index to Pesticide Chemicals 0 ,0—DIETHYL S— [ 2—(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE Site and Pest Dosages and Tolerance, Use, Limitations Formulation(s) Pecan (continued) 0.25—0.375 Foliar application. Repeat as ib/ICO gal needed. [ up to 400 gal/Al (6—8 lb/gal EC) 0.75—1 lb/A Foliar application by aircraft. Ap— (6 lb/gal EC) ply in a minimum of 5 gallons of water per acre. /28017AA Peppers This use only occurs on 24(c) Spe- cial Local Need labeling and has not been included in this entry. Refer to appropriate labeling for use in- formation. /06013AA Pineapple 0.75 ppm (pineapple) 5 ppm (pineapple foliage) 5 ppm (pineapple bran) 60 day preharvest interval through 2.5 pounds per acre when 2 applica- tions are made. Do not make more than 2 applications during crop period. Do not ensile foliage less than I year after last application when 2 applications are made. IRAWAA.A Mealybugs 2.5 lb/A Soil application. Apply as a broad— (5—15% G) cast application or apply topically by base leaf feeding after plants have developed root system. 2.5 lb/A Use limited to III. (6—8 lb/gal Soil application. Apply with liquid EC) fertilizer as a soil injection. Plum (nonbearing) See Apple (nonbearing) cluster. Issued: 5—11—82 111—032501—16 ------- EPA Index to Pesticide Chemicals 0,0-DIETRYL s- [ 2-(ETHYLTHIO)ETHYL] ?HOSPHORODITHIOATE Site and Pest Dosages and Formulation(s ) Tolerance, Use, Limitations Aphids 3—4 lb/A (5—15% C) (6—8 lb/gal EC) 0.75 ppm 30 day preharvest interval through 1 pound per acre for foliar or sprinkler irrigation application. Do not make more than 3 foliar or sprinkler irrigation applications during the growing season. 60 day preharvest interval through 3 pounds per acre for sprinkler irrigation application. Do not make more than 1 sprinkler irrigation application during the growing sea- son. 75 day preharvest interval through 3.5 ounces per 1,000 feet of row for soil application. Do not make more than 2 soil applications during the growing season. Do not tank mix with phosa].one. Preplant broadcast soil application. Incorporate to a depth of 2 to 3 inches by disc or other suitable equipment. IRACAAA INAMCFA INANADA IRAFAAA IRAXAHA tNAVAFA Aphids (Colorado potato beetle (early season)) Flea beetles (except tuber flea beetles) Lea fhopper s Potato psyllid Southern potato weevil 2.25—3.5 oz/ 1,000 ft row (0.25—15% C) (6—8 lb/gal EC) 0.024—0.036 oz/lO ft row (1—2% G) I R.ACCUA Green peach aphid 0.375—1 lb/A (6—8 lb/gal EC) Foliar application. Apply when pest first appears. Apply higher rates for heavy infestation. Repeat as needed. In AZ and CA do not apply to the Centennial variety. / I4O13AA Potato ERACAAA or Soil application at planting (double band or in furrow). Apply in the furrow or in a band on each £side of the furrow. Spray emulsifiable con— centrate when applying in furrow. OR Postemergent soil application (band). Apply as a sidedress after plants become established. Apply higher rate on organic soils. Issued: 5—11—82 111—032501—17 ------- EPA Index to Pesticide Chemicals 0, 0-DIETHYL S— [ 2—(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE Site and Pest Dosages and Tolerance, Use, Limitations Formulation(s) Potato (continued) INAIICFA Colorado potato 1—3 lb/A Use limited to CA, ID, OR, UT, and beetle (6—8 lb/gal WA. IRACCUA Green peach aphid EC) Sprinkler irrigation application. Solid set systems , apply during the entire length of the irrigation period, or for a 30 to 60 minute period at the end of a regular irrigation set, or as a 30 to 60 minute irrigation as a separate application not associated with regular irrigation. Center pivot systems , inject continuously for I complete revolu- tion of the system. Do not apply when wind velocities exceed 10 miles per hour. Prune (nonbearing) See Apple (nonbearing) cluster. Radish (seed crop) See Carrots (seed crop) cluster. /O1006DA Raspberry (nursery stock) N.F. IRACAAA Aphids 8 lb/A Use limited to Northeast states. (15% G) Soil application to new or estab- lished plantings (band). Apply 24 inch band over row. Incorporate into top 2 to 3 inches of soil using a cultivator or other suitable equipment. A second soil applica- tion may be made later in the sea- son. Consult state agriculture extension service for proper timing. /28020AA Rice 0.75 ppm (rice) 5 ppm (rice straw) 100 day preharvest interval through 2 pounds per acre for broadcast soil application. Do not make more than 2 applications during the growing season. IRAFAAA Leafhoppers 2 lb/A Broadcast soil application at plant— (5—15% C) ing or prior to flooding. Issued: 5—11—82 111—032501—18 ------- EPA Index to Pesticide Chemicals 0, 0—DIETHYL S— [ 2—(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE Site and Pest Dosages and Formulation(s ) Tolerance, Use, Limitations 0.9—1.2 oz/ 1,000 ft row (0.625—15% C) (6—8 lb/gal EC) 1.2 oz/l,000 ft row (5—15% G) (6—8 lb/gal EC) 0.75 ppm (grain) 5 ppm (fodder and forage) 30 day preharvest interval for granular formulations through 1.2 ounces per 1,000 feet of row for 3 foliar applications and 1 soil application (grain). 14 day preharvest/pregrazing inter- val for granular formulations through 1.2 ounces per 1,000 feet of row for 3 foliar applications and 1 soil application (fodder and forage). 34 day preharvest/pregrazing inter- val for emulsifiable concentrate formulations through 0.5 pound per acre for 3 foliar applications and 2 soil applications (grain and for- age and fodder). 7 day preharvest interval for emul- sifiable concentrate formulations through 1 pound per acre for 2 foliar applications when no soil applications have been made (grain). 28 day preharvest/pregrazing inter- val for emulsifiable concentrate formulations through 1 pound per acre for 2 foliar applicatio is when no soil applications have been made (forage and fodder). Observe resistance statement. Soil application at planting (in furrow). Apply 0.5 inch above seed. Do not apply directly on the seed. Soil application at planting (band). Apply a 4 to 6 band inch behind planter shoe in front of press wheel. Do not apply directly on the seed. /28O19AA IRACDNA Greenbug Issued: 5—11—82 111—032501—19 ------- EPA Index to Pesticide Chemicals 0 ,0—DIETHYL S—(2—(ETHYLTHIO)EThYLJ PHOSPHORODITUIOATE Site and Pest Sorghum (continued) Dosages and Formulation(s ) 1.2 oz/l,000 ft row (5—15% G) Tolerance, Use, Limitations Foliar application. Broadcast into whorls. 1.2 oz/l,000 ft row (6—8 lb/gal EC) 0.25—0.5 lb/A (6—8 lb/gal EC) Postemergent soil application (side— dress). Inject into the row on both sides of the furrow any time up to boot stage. Foliar application. I OANAIA Sorghum midge 0.25—0.5 lb/A (6—8 lb/gal EC) Use limited to AR, LA, OK, and TX. Foliar application. Apply when 50 percent of the 8eed heads emerge from the boot. Make second applica- tion 3 to 5 days later. ILAVANA Banks grass mite 0.5—1 lb/A (6—8 lb/gal EC) Use limited to OK and TX, excluding the Trans Pecos area. Foliar application. Apply in a minimum of 1 gallon of water per acre by aircraft or in a minimum of 5 gallons of water per acre by ground equipment. 0.1 ppm (soybeans) 0.25 ppm (forage and hay) Banded soil application (at time of planting) through 1.2 ounces per 1,000 feet of row. Do not apply directly on the seed. Soil application at planting (band or double band). Apply a 4 inch band over the seed furrow behind the planter shoe in front of the press wheel or apply a band on each side of the seed furrow. /28023AA Soybeans INAPAFA IMOAA.AA Mexican bean beetle Thrips (excluding flower thrips) 1.2 oz/l,000 ft row (5—15% G) Issued: 5—11—82 111—032501—20 ------- EPA Index to Pesticide Chemicals 0,0—DIETHYL S— [ 2—(ETHYLTUIO)ETHYLJ PHOSPHORODITHIOATE Site and Pest Dosages and Formulation(s ) Tolerance, Use, Limitations / 28023 BA IR.ACAAA IRAFAAA ILAAABA M0AAAA Soybeans (seed crop) N.F. Do not pasture or use treated crop for feed, food, or forage. Soil application to seed crop at planting (double band). Apply in a band on each side of the seed fur- row. Do not apply directly on the seed. Postemergent soil application to seed crop (band). Apply as a side— dress after plants are established. Spinach 0.75 ppm Banded soil application (at time of planting) through 0.6 ounce per 1,000 feet of row. 0.6 oz/l,000 ft row (0.4—15% C) (6—8 lb/gal EC) or 0.006 oz/ 10 ft row (1—2% C) / 0101 6DA Strawberries (propagating plants) N.F. Do not use fruit from treated plants for food purposes. Soil application. Apply granular by sidedressing on each side of the row or by broadcasting over the row. Apply emulsifible concentrate as a soil injection on each side of the row. Repeat as needed. RACAAA Aphids 1.2 oz/l,000 £RAFAAA Leafhoppers ft row ILAAABA Mites (5—15% C) IMOAAAA Thrips / 13024AA OR Aphids Lea fhoppers Mites Thr i PS Soil application at planting (double band). Apply in a band on each side of the seed furrow. Do not apply directly on the seed. IRACAAA Aphids 2.55—5.2 oz/ U.AAABA Mites (except cyclaman mite) 1,000 ft row (5—15% G) (6—8 lb/gal EC) Issued: 5—11—82 111—032501—21 ------- EPA Index to Pesticide Chemicals 0, 0-DIETHYL S— ( 2—( ETIIYL.ThIO) EThYL] PHDSPHORODIThIOATE / 28020AA Site and Pest Sugar Beets Dosages and Formulation(s ) 0.9 oz/l,000 ft row (0.25—15Z G) (6—8 lb/gal EC) Tolerance, Use, Limitations 0.5 ppm (sugarbeets) 2 ppm (tops) 5 ppm (dehydrated sugar beet pulp) 30 day preharveat interval through 0.9 ounces per 1,000 feet of row for soil application. Do not apply more than 3 applica- tions during growing season. Allow a minimum of 21 days between post— emergent soil applications. Observe plant response precaution. Soil application at planting (in furrow). Apply in seed furrow 2 inches under the seed. Do not apply directly on the seed. Soil application at planting (double band). Apply in a band on both sides of the furrow. Do not apply directly on the seed. Postemergent soil application. Apply granular to foliage and crown. Apply emulsifiable concentrate as a sidedress after plants are estab- lished. IOAC ABA Root maggots 0.675—0.7 oz 1,000 ft row (l0—l5 C) Use limited to MN and ND. Soil application at planting (band). Apply 4 to 6 inch band directly be- hind planter shoe in front of the press wheel. The granules should be placed 1 inch above the seed. Do not apply directly on the seed. Aphids 6—9 az/A (6—8 lb/gal EC) 0.3 ppm 28 day preharvest interval through 9 ounces per acre for foliar appli- cation. Do not make more than 4 applications during the growing season. Use limited to PR. Foliar application. May be applied by aircraft in approximately 4 gal— ions of water per acre. Apply when pest first appears. IRACAAA IRAFA.AA ILAAABA Aphids Lea fhoppers Mites OR OR 125003AA Sugarcane IRACAAA Issued: 5—11—82 111—032501—22 ------- EPA Index to Pesticide Chemicals 0,0-DIETHYL S- [ 2—(ETHYLThIO)ETHYLI PHOSPHORODITHIOATE Site and Pest Dosages and Tolerance, Use, Limitations Formulation(s ) /26003AA Tobacco N.F. /26006AA Do not make more than 1 application during the growing season. IRACAAA Aphids 3—4 lb/A Preplant broadcast soil application. INANADA Flea beetles (1.33% C) Apply immediately before transplant— INAVAFA (Southern potato ing and incorporate into the top 2 wireworm) to 3 inches of soil. 3—6 oz/l,000 Preplant soil application (band). ft row Apply 6 to 12 inch band over the (5—15% C) row, incorporate into top 2 to 3 inches of soil, set transplants into the treated row. OR Preplant broadcast soil application. Incorporate into top 2 to 3 inches of soil. INANADA Flea beetles 4 lb/A Preplant broadcast soil application. (6—8 lb/gal Incorporate into the top 2 to 3 in— EC) ches of soil. /26006AA (Tobacco Flue Cured) IRACAAA Aphids 4 lb/A Use limited to GA and VA. (6 lb/gal EC) Preplant broadcast soil applica- tion. Incorporate into the top 2 to 3 inches of soil. /26003DA Tobacco (transplant beds) N.F. Do not apply more than I application to transplant bed. IRACAAA Aphids 3.75 oz/2,500 Preplant broadcast soil application. INANADA Flea beetles sq. ft Incorporate into top 2 to 3 inches (10—15% G) of soil. OR Postemergent broadcast soil applica- tion. Apply over plants after emer- gence and water thoroughly. Issued: 5—11—82 111—032501—23 ------- EPA Index to Pesticide Chemicals 0, 0-DIETHYL s—(2—(EmYLThI0)ETIWLI PHOSPHORODIThIQATE / 1IOO5AA Site and Pest Tomato Dosages and Formulation(s ) Tolerance, Use, Limitations 0.75 ppm 30 day preharvest interval through 11 ounces per 1,000 feet of row (72 inch row spacing) for soil applica- tion. Do not make more than 1 application during the growing season. 30 day preharvest interval through 5.5 ounces per 1,000 feet of row (72 inch row spacing) for soil application. Do not make more than 2 applications during the growing season. Observe plant response precaution. I.RACAAA INAZICFA IRAFAAA IMAAAGA ILAAABA Aphids (Colorado potato beetle (early sea- son)) Lea fhopper s Leafminers Mites 1.2—3.5 oz/ 1,000 ft row El applica- tion] 1.2—2.4 oz/ 1,000 ft row [ 2 applica- tions] (0.25—15% G) (6—8 lb/gal EC) 3.5—11 oz/ 1,000 ft row [ 72 in. row spacing) El applica- tion) or 2.4—5.5 oz/ 1,000 ft row (72 in. row spacing] [ 2 applica- tions] (5—15% G) (6—8 lb/gal EC) Use limited to highly alkaline soils in FL. Soil application at planting (double band). Apply band on each side of seed furrow or transplant row. Do not apply directly on the seed. OR Postemergent soil application (band). Apply as a sidedress. Al- low a minimum of 21 days between ap- plications. or Soil application at planting (double band). Apply band on each side of seed furrow or transplant row. Do not apply directly on the seed. OR Postemergent soil application (band). Apply as a sidedress. Al- low a minimum of 21 days between ap— plicat ions. Issued: 5—11—82 111—032501—24 ------- EPA Index to Pesticide Chemicals 0,0—DIETHYL S— [ 2—(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE Site and Pest Dosages and Tolerance, Use, Limitations Formulation(s) Tomato (continued) -IRACAAA Aphids 0.02—0.036 Soil application at planting (double INANADA Flea beetles oz/lO ft row band). Apply band on each side of IRAFAAA Leafhoppers [ 1 applica— seed furrow. Do not apply directly IMAAAGA Leafminers tion on the seed. ILAAABA Mites (1—2% G) OR or Postemergent soil application (dou— 0.02 oz/l0 ft ble band). Apply band on each side row of row as sidedress. Allow 21 days [ 2 applica— between applications. .tions) (2% C) 4 tsp 1% G Soil application to transplant hole. or Mix with soil before setting plant. 2 tsp 2% C/ plant (1—2% C) /I1005DA Tomato (transplant beds) 0.75 ppm Broadcast soil application to trans- plant beds through 3 pounds per acre. Do not make more than I application. IRACAAA Aphids 2.75 oz/2,500 Preplant broadcast soil application INA14CFA (Colorado potato sq. ft to transplant beds. Incorporate beetle (early (5—15% G) into top 2 to 3 inches of soil. season)) (6—8 lb/gal OR LRAFAAA Leafhoppers EC) Postemergent broadcast soil applica— IMAAAGA Leafminers tion to transplant beds. Apply ILAAABA Mites granular over plants after emer- gence. Water thoroughly. Turnips (seed crop) See Carrots (seed crop) cluster. Issued: 5—11—82 111—032501—25 ------- EPA Index to Pesticide Chemicals 0 ,O—DIETHYL S— [ 2-(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE Site and Pest Dosages and Tolerance, Use, Limitations Formulation(s ) /28065AA Wheat 0.3 ppm (grain) 5 ppm (green fodder and straw) 30 day preharvest interval through 0.75 pounds per acre for foliar ap- plication. For emulsifiable concentrate formu- lations: Fall application . Two applications may be made. Allow 30 days between applications. Spring application . Application at green up may be made following fall applications. An additional spring application may be made 30 days fol- lowing the first spring application. Observe resistance statement. IRACDNA Greenbug 0.25—0.75 Use limited to AL, TN, and all ILAAABA Mites lb/A states west of the MI River. (6—8 lb/gal Foliar application. Apply the lower EC) rates up to tillering (stooling) and higher rates after plants begin to tiller. 0.375—0.75 Use limited to AL, TN, and all lb/liquid states west of the MI River. fertilizer/A Foliar application. Apply as a top— (6—8 lb/gal dress by ground equipment. EC) 0.75 lb/A Broadcast application. Apply as a (0.75% G) topdress any time after crop is well established. IRACAAA Aphids (including 1 lb/A Broadcast soil application at fall greenbug, oat (0.4—1% C) planting. bird, cherry) or OR IVABAAA Grasshoppers 0.25 oz/l,000 Soil application at fall planting IDAHAQA Hessian fly ft row (band). Apply 3 inch bands by (5—15% C) drilling granular formulations. (6—8 lb/gal EC) Issued; 5—11—82 111—032501—26 ------- EPA Index to Pesticide Chemicals 0, 0—D IETHYL S— [ 2- ( ETHYLTUIO ) ETHYL] PHO SPROROD ITHIOATE Site and Pest Dosages and Formulation(s ) Tolerance, Use, Limitations /3I000AA ORNANENTALS General Warnings and Limitations : Preplant treatments to flowers, shrubs, and trees. Apply evenly to seed bed and incorporate into soil. Plant in usual manner. Established plants may be treated by applying uniformly under foliage canopy. Incorporate into topsoil and water to accelerate entry into the plant. In commercial topping of flowers by hand, clean gloves (cotton or natural rubber) should be worn. When applying in green- houses or other enclosed areas wear a respirator jointly approved by the Mining Enforcement and Safety Administration (formerly the United States Bureau of Mines) and by the National Institute for Occupational Safety and Health. ( Ornamental Plants (herbaceous, woody shrubs, trees and vines) Ornamental Ilerbaceous Plants I tsp 2% Cl plant (1—2% c) 0.053—0. 107 ozllO sq ft (1—2% C) Preplant broadcast soil application. Incorporate into the top 1 to 3 inches of soil. Soil application. Apply around base of established plants. Soil application to established plants (band). Apply near base of plants. Apply higher rate on muck or heavy organic soils. 5.3—10.7 oz/ 1,000 ft row (5—15% G) Soil application Apply band over, side of the row. on muck or heavy at planting (band). the row or on each Apply higher rate organic soils. /31093AA / 31111 AA IRACAAA IQAXAAA I RAFAAA ILAAABA IMOAAAA IRA BAAA (Easter Lily) (Gladiolus) Aphids Lacebugs Lea fhoppers Mites Thrips Whitef lies 5.3—10.7 oz/ 1,000 ft row (5—15% C) Refer to (Ornamental Houseplants), Ornamental Herbaceous Plants for additional information. IRACAAA Aphids 0.08—0.48 ozl IQAXAAA Lacebugs 100 sq ft IRAFAAA Leathoppers (1—2% G) ILAAABA Mites IMOAAAA IRABAAA Thrips Whiteflies 2 tsp or 1% C Soil application at planting (in furrow). Apply over bulbs before covering with soil. Do not apply in furrow application to garden lily bulbs. Apply higher rate on muck or heavy organic soils. IssuedI 5—11—82 111—032501—27 ------- EPA Index to Pesticide Chemicals 0, 0—D IETMYL S— [ 2—( ETHYLTHIO) ETI4YL] PHOSPHOROD ITHIOATE Site and Pest Dosages and Tolerance, Use, Limitations Formulation(s ) /35000AA Ornamental Trees /34004AA Ornamental Woody Shrubs /34120AA IRACAAA Aphids 0.02 ozf ft of Soil application to established INAMOAA Elm leaf beetle growth plants. Incorporate into top 1 to IQAXAAA Lacebugs [ plants 1—3 2 inches of soil. Repeat at 28 to IRAFAAA Leafhoppers ft] 42 day intervals. INAAAGA Leafminers or ITAOACA Mimosa webworms 0.04 oz/ft of ILAAABA Mites growth ITBGACA Pine tip moth/Pine [ plants 3—6 shoot moths ft] IRAAABA Scales or IMOAA.AA Thrips 0.06 ozfft of IRABAAA Whiteflies growth [ plants 6—12 ft I or 0.24 oz/in. of tree trunk diameter (0.99—2% G) 0.5carcrige Soil application to established 2% P/T/3 ft plants. Attach provided root feeder of growth to garden hose and use a gentle and flow of water. Apply evenly under 0.5 cartrige/ drip line. Begin application in additional early spring when new growth appears ft of growth and repeat at 42 day intervals as (2% P/T) needed. For trees, insert root feeder into root zone. For shrubs, insert root feeder up to 12 to 14 inches in the ground. For shallow rooted plants do not insert as deep but never less than 6 inches. (Rose) IRACAAA Aphids 0.016—0.03 oz Soil application at planting. IQAXAAA Lacebugs /plant Divide dosage and apply to bottom IRAFA.AA Leafhoppers (0.99—1% C) of hole and the remainder to the top IMAA.AGA Leafminers 2 inches of soil. Water thoroughly. ILAAABA Mites IRAAABA Scales IMOAAAA Thrips IRABAAA Whiteflies Issued: 5—11—82 111—032501—28 ------- EPA Index to Pesticide Chemicals 0,0—DIETIIYL S—(2-(ETUYLThIO)EThYL] PHOSPRORODITHIOATE Site and Pest Dosages and Formulation(s ) Tolerance, Use, Limitations Ornamental Trees cluster (continued) 0.02 oz/plant (polyantha and hybrid tea roses) or 0.04 oz/plant (bush roses] or 0.08 oz/plant climbers (1% C) 0.32 oz/l00 sq ft (0.99% G) Soil application to e8tablished plants. Incorporate into top 1 to 2 inches of soil. Apply when 1 inch of growth appears in the spring. Repeat at 42 day intervals. ERACAAA INANOAA IQAXAAA IRAFAAA IMAAACA ITAOACA tLAAABA ITBCACA IRAAABA IMOAAAA I RABAAA Aphids Elm leaf beetle Lacebugs Leafhoppers Leafminers Mimosa webworms Mites Pine tip moth/Pine shoot moths Scales Thrips Whiteflies 0.375—4 oz/ plant or 0.375 oz/in. of tree trunk d lame t er (5—15% C) 1.07—2.5% clay slurry (10—15% G) Soil application to established plants. Apply higher per plant dosage for muck or heavy organic soils. Soil application at planting. Apply equivalent amount to transplant hole. Root dip prior to planting. or /35 000DA / 34004DA 130006AA Ornamental Trees Ornamental Woody (nursery stock) Shrubs (nursery stock) Issued: 5—11—82 111—032501—29 ------- EPA Index to Pesticide Chemicals 0, O-D IETHYL s— [ 2—( ETHYLTEIO ) ETHYL] PHOSPHOROD ITILIOATE Site and Pest Dosages and Tolerance, Use, Limitations Formulation(s) ( Ornamental Houseplants ) /3 I000AA Ornamental Herbaceous Plants (Houseplants) IRACAAA Aphids 2 tsp 1% C Soil application to potted plants. IQAXAAA Lacebugs or Thoroughly mix with soil and drench IRAFAAA Leafhoppers 1 tsp 2% G/ with water. IMAAAGA Leafminers 6 in. pot IRAWAAA Mealybugs (1—2% G) ILAAABA Mites or IRAAABA Scales 2 tsp 2% C IMOAAAA Thrips 8 in. pot IRABAAA Whiteflies or I tbls 2% C 10 in. pot (2% G) FOREST, CHAPARRAL, NONAGRICULTURAL AND WASTELANDS /30006AA Forest Plantings Refer to ORNAMENTALS, Ornamental Trees (nursery stock) cluster. 9999999 AERIAL, MOTHPROOFING AND TANK MIX APPLICATIONS 9001500 Aerial Application AAAAAAA Refer to AGRICULTURAL CROPS Alfalfa, Alfalfa (seed crop), Bar— ley, Clover, Clover (seed crop), Corn, Oats,_Peanuts, Peas, Pecan, Pineapple, Potato, Rice, Sorghum, Sugarcane, Tobacco, Tobacco (flue cured), Wheat Issued: 5—11—82 111—032501—30 ------- EPA Index to Pesticide Chemicals 0, 0-D IETHYL s- [ 2-(ETHYLTHIO ) ETHYL] PHOSPHOROD ITHIOATE Listing of Registered Pesticide Products by Formulation 95% technical chemical 00, diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 003125—00183 2% formulation intermediate 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 003125—00120 2.2% formulation intermediate 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 009649—00003 5% formulation intermediate 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 003 125—00 130 68% formulation intermediate 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 003125—00158 0.25% granular 0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 006735—00158 010501—00001 0.28% granular 0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 042057—00069 0.33% granular 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 010554—00002 0.4% granular 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 002124—00408 0.5% granular 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 000912—00043 003120—00006 006735—00161 007192—00006 010501—00002 010554—00003 0.625% granular 0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 003120—00007 007001—00115 0.672 granular 0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 000912—00040 Issued: 5—11—82 111—032501—31 ------- EPA Index to Pesticide Chemicals 0,0-DIETHYL S- [ 2—(ETHYLTHIO)ETHYL] PHOSP}LORODITUIOATE Listing of Registered Pesticide Products by Formulation (continued) 0.75% granular 0,0, —diethy]. S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 006735—00 160 007192—00008 0 10554—0004 0.8% granular 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 003120—00008 0.99% granular 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 007401—00004 1% granular 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 000004—00253 000192—00126 000239—02134 000802—00426 000869—00076 000904—00138 000912—00042 002125—00042 003120—00009 003125—00152 003770—00196 005719—00079 005887—00061 008660—00004* 006735—00159 007001—00313 007192—00005 007401—00235 009404—00003 010554—00001 010554—00005 033313—00004* 04205 7—00051 42057—00052 *jacket currently unavailable for review 1.33% granular 0 ,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 006735—00199 2% granular 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 000004—00153 000192—00074 000192—00119 000602—00146 000769—00515 001685—00049 001769—00167 003125—00083 003125—00 116 003125—00126 005605—00102 007401—00026 008222—00036 033955—00490 045085—00021 5% granular 0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 003125—00058 10% granular 0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 003125—00061 15% granular 0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 000226—00 192 002393—00423* 002749—00233 003125—00172 *jacket currently unavailable for review 2% pelleted/tableted 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 009649—00001 Issued: 5—11—82 111—032501—32 ------- EPA Index to Pesticide Chemicals 0 ,0—DIETHYL S— [ 2—(ETHYLThIO)ETHYL] PHOSPHORODITHIOATE Listing of Registered Pesticide Products by Formulation (continued) 6 lb/gal emulsifiable concentrate 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) plus aromatic petroleum solvent (006601) 003125—00119 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) plus xyleae (086802) 002749—00290 8 lb/gal emulsifiable concentrate 0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) plus aromatic petroleum solvent (006601) 003125—00307 95 ready—to—use 0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) 003125—00173 State Label Registrations AZ Reg. No. 001526—03794 002935—09021 003125—07856 003125—07857 CA Reg. No. 003125—07840 00700 1—07725 007001—07738 007001—07739 007001—07740 007001—07741 007001—07742 011149—04662 0 11149—04664 GA Reg. No. 00673 5—08 174 HI Reg. No. 0 3784 3—08 5 70 ID Reg. No. 003 125—07833 OR Reg. No. 000483—04584 000483—04585 000483—04586 000483—04587 000483—04588 000483—04589 001871—08933 00187 1—09816 00187 1—09817 00187 1—09818 00187 1—09823 011656—05895 035497—04491 035497—04492 WA Reg. No. 003125—07827 WI Reg. No. 021713—10125 021713—10134 035329— 10124 Issued: 5—11—82 111—032501—33 ------- EPA Index to Pesticide Chemicals 0, O—D IETHYL s— [ 2— ( ETHYLTHIO ) ETHYL] PHOSPHOROD ITHIOATE Appendix A Listing of Common Chemical Names TJsed on the Entry Chemical Con non Name EPA Acceptable Code (source) Common/Chemical Name 032701 fensulfothion o,o—diethyl o— [ p—(inethylaulfynl) phenyl] phosphorothioate Issued: 5—11—82 111—032501—34 ------- II. REQUIREMENT FOR SUBMISSION OF GENERIC DATA A. This portion of the guidance document is a Notice issued under the authority of FIFRA sec. 3(c)(2)(B) and describes, in table format, the data required for maintaining the registra— bility of each product. Additionally, a bibliography (Appendix 11—2) is included that identifies that data considered as part of the data base supporting this standard. EPA has determined that additional generic data described in this Notice must be submitted to EPA for evaluation in order to maintain in effect the registration(s) of your product(s) identified as an attachment to the cover letter accompanying this guidance document. As required by FIFRA sec. 3(c)(2)(B), you are required to take appropriate steps to comply with this Notice. EPA may suspend the registration of each of those products unless, within the specified time, you have informed EPA how you will satisfy the requirements of this Notice. Any such suspension will remain in effect until you have complied with the terms of this Notice. B. What Generic Data 1 ! Must be Submitted . You may deter- mine which generic data you must submit by consulting Table A at the end of this chapter. That table lists the generic data needed to evaluate the continued registrability of all products, and the dates by which the data must be submitted. The required studies must be conducted in accordance with EPA approved protocols (such as those contained in the Pesticide Assessment Guidelines 2/ or data collected under the approved protocols of the Organization for Economic Cooperation and Development (OECD). If you wish not to develop data which are necessary to support the reregistration of certain uses appearing in your labeling, you may delete those uses at the time you submit your revised labeling. Also for certain kinds of testing (generally ecological effects), EPA requires the test substance to be a “typical 11 Generic data pertain to the properties or effects of a particular ingredient, and thus are relevant to an evaluation of the risks of all products containing that ingredient (or all such products having a certain use pattern), regardless of any such product’s unique composition or use. Product—specific data relate only to the properties or effects of a product with a particular composition (or a group of products with closely similar composition). 2/ The Pesticide Assessment Guidelines are available in hard copy or microfiche from the National Technical Information Service, 5285 Port Royal Road, Springfield, Va. 22161. 40 ------- formulation,” and in those cases EPA needs data of that type for each major formulation category (e.g., emulsifiable concen- trates, wettable powders, granulars, etc.) These are classified as generic data and when needed are specified in Table A. EPA may possess data on certain “typical formulations” but not others. Note : The “typical formulation” data should not be confused with product—specific data (Table B) which are required on each formulation. Product—specific data are further explained in Chapter III of this document. C. Options Available for Complying With Requirements to Submit Data Within 90 days of your receipt of this Notice you must submit to EPA a completed copy of the form entitled “FIFRA Section 3(c)(2)(B) Summary Sheet” (EPA Form 8580—1, Appendix 11—31 for each of your products. On that form you must state which of the following methods you will use to comply with the requirements of this Notice: 1. (a) Notify EPA that you will submit the data, and (b) either submit the existing data you believe will satisfy the requirement, or state that you will generate the data by conducting testing. If the test procedures you will use deviate from (or are not specified in) the pesticide Assessment Guidelines or protocols contained in the Reports of Expert Groups to the Chemicals Group, Organization for Economic Cooperation and Development (OECD) Chemicals Testing Programme, you must enclose the protocols you will use. OR 2. Notify EPA that you have entered into an agreement with one or more other registrants to jointly develop (or share in the cost of developing) the data. If you elect this option, you must notify EPA which registrant(s) are parties to the agreement. 3. File with EPA a completed “Certification of Attempt to Enter Into an Agreement With Other Registrants for Develop- ment of Data” (EPA Form 8580—6, Appendix II_4)*/ OR / FIFRA sec. 3(c)(2)(B) authorizes joint development of data by two or more registrants, and provides a mechanism by which parties can obtain an arbitrator’s decision if they agree to jointly develop data but fail to agree on all the terms of the agreement. The statute does not compel any registrant to agree to develop data jointly. (Footnote continued on next page) 41 ------- 4. Request that EPA amend your registration by deleting the uses for which the data are needed. (This option is not available to applicants for new products.) OR 5. Request voluntary cancellation of the registration(s) of your products for which the data are needed. (This option is not available to applicants for new products.) D. Procedures for Requesting Changes in Testing Methodology and Extensions of Time EPA recognizes that you may disagree with our conclusions regarding the appropriate ways to develop the required data or how quickly the data must be submitted. If the test procedures you plan to use deviate from (or are not specified in) the registration guidelines or protocols contained in the reports of the Expert Groups to the Chemical Groups, Organization for Economic Cooperation and Development (OECD) Chemicals Testing Programme, you must submit the protocol for Agency review prior to the initiation of the test. If you think that you will need more time to generate the required data than is allowed by EPA’s schedule, you may submit a request for an extension of time. Th& extension request must be submitted in writing to the Product Manager. The extension request should state the reasons why you conclude that an extension is appropriate. While EPA considers your request, you must strive to meet the deadline for submitting the required data. (Footnote continued from previous page) In EPA’s opinion, joint data development by all registrants who are subject to the requirements to submit a pertinent item of data or a cost—sharing agreement among all such registrants is clearly in the public interest. Duplication of testing could increase costs, tie up testing facilities, and subject an unneces- sarily large number of animals to testing. As noted earlier, EPA has discretion not to suspend the registration of a product when a registrant fails to submit data required under FIFRA Section 3(c)(2)(B). EPA has concluded that it is appropriate to exercise its discretion not to suspend in ways which will discourage duplicative testing. Accordingly, if (1) a registrant has informed us of his intent to develop and submit data required by this Notice; and (2) a second regis- trant informs EPA that it has made a bona fide offer to the first registrant to share in the expenses of the testing [ on terms to be agreed upon or determined by arbitration under FIFRA Section 3(c)(2)(B)(iij)]; and (3) the first registrant has declined to agree toenter into a cost—sharing agreement, EPA will not suspend the second firm’s registration. 42 ------- III. REQUIREMENT FOR SUBMISSION OF PRODUCT—SPECIFIC DATA A necessary first step in determining which statements must appear on your product’s label is the completion and submission to EPA of product—specific data* listed on the form entitled “Product Specific Data Report” (EPA Form 8580—4, Appendix 111—1) to fill “gaps identified by EPA concerning your product. Under the authority of FIFRA Sec. 3(c)(2)(B), EPA has determined that you must submit these data to EPA in order to reregister your product(s). All of these data must be submitted not later than six months after you receive this guidance document. “Product—Specific Data Requirements for Manufacturing Use Products” appearing in Table B permit you to determine which product—specific data you must submit. This can be done by examining the entries in the column of those tables entitled “Must Data By Submitted Under §3(c)(2)(B).” / Product specific data pertain to data that support the formulation which is marketed; it usually includes product chemistry data and acute toxicity data. 43 ------- TABLE A GENERIC DATA RE OIREME ’IS R)R DISULFtY1DN Test Substance 1 ! Guidelines Status 2 ! Are Data Required 3 ! Footnote Nunber Data Requirement §158.120 — Product Chemistn Product Identity : 61—1 — Identity of Ingredients 61—2 — Statement of Ccxnpositjon 1 AI R E ] R [ ] [ 1 61—3 — Discussion of Formation of R [ J [ J Ingredients Analysis and Certification of Product Ingredients 62—1 — Preliminary Analysis ¶flAI R [ J [ ] 62—2 — Certification of Limits i Ai R [ X] fl 62—3 — Analytical Methods for It A1 R (XI I) Enforcement of Limits Physical and Chemical Characteristics 63-2 - Color AI R [ J F] 63—3 — Physical State ICAI R [ X l [ ] 63—4 — Odor ltAI R [ XI [ ] 63-5 — Melting Point R [ =1 [ I 4! d 1 ------- TGAI R ( ] [ =1 1 GM R [ ] [ =1 1 GAI0rPAI R [ ] [ :1 PA l R [ ] [ =1 PAl R [ ] C) PAl R E ) 1GM R I P3A1 R EXI CI 1GM R [ =1 Choice C i E I TABLE A GENERIC DATA REX UIREMEN1’S FGR DISULEUPON Test SubstanceV Guidelines Status 2 / Are Data Required 3 ’ Yes No Footnote Number Data Requir 1leflt §158.120 — Product Chemistry (con’t) Physical and Chemical Characteristics (Continued) 63—6 — Boiling Point 63—7 — Density, Bulk Density, or Specific Gravity 63—8 — Solubility 63—9 — Vapor Pressure 63—10 — Dissociation constant 63—11 — Octanol/water partition coefficient 63—12 — pH 63—13 — Stability 63—20 — Corrosion Characteristics Other Requirements : 64—1 — Suth ittal of samples CR 45 ------- TT BLE A GENERIC DPiTA RFX (JIREMENTS FOR DISULFtIflJN §158.120 — Product Chenistry (continued) DPJTA REX UIRENEm F’CXYTh GrES: 1/ Test Substance: IT AI= Technical grade of the active ingredient; PAI= Pure active Ingredient; Choice= choice of several test substances determined on a case—by—case basis. 2/ Guideline Status: R= Required; CR Conditionally required 3/ Data must be subuitted by _____________________ 4/ Not required because the 95% technical is a liquid at roars tenperature 46 ------- TABLE A G ERIC DPATA RE UIREME 1’S FOR DISULFU ON Does EPA Have Data Must Additional To Satisfy This Data Be Sutinitted Requirement? (Yes, Data Requirement CclTlposition 1 / No, or Partially) Bibliographic Citation Under FIFRA Section 3(c)(2)(B)? 2 / §158.125 Residue Chemistry 171—4 — Nature of Residue (Metabolism) — Plants PAIRA Partially GSO1O20 0 1* Yes 3 ! GS0102002* GS0102003* GS0102004* GS0 102005* 00032409* 00096498* — Livestock PAIRA and plant Partially GSO1O2001* Yes 4 ’ 5 ! rnetabol ites GS0102006*a/ 171—4 — Residue Analytical Method — Plant residues I AI and metabolites Partially GS0102003* Yes 6 ! GS0102004* GSO 102013* GS0102007* GSO1 O2 008* GS0 102009* GSO 102010* CS O 1O2 O11*b/ GSO1O 2012* b/ GS0102014* 00071243* 00071237* 47 ------- TABLE A GENERIC DATA REX )UIREMENfS FOR DISULFOTON Does EPA Have Data Must Additional To Satisfy This Data Be Sutinitted Requirenent? (Yes, Data Require ent Cmpositionl-/ No, or Partially) Bibliographic Citation Under FIFRA Section 3(c)(2)(B)? 2 / §158.125 Residue Chenistry (continued) 171—4 — Residue Analytical Method (continued) — Plant residues (continued) 00071233* 0004 1055* 00032409* 00028780*a/ — Animal residues ICAI and inetabolites Partially GS0102006*W Yes 6 ’ GS0102007* GS01020 14* 00071245* 171—4 — Storage Stability Data PAl Yes GS0102002* No GS0102015* GS0102006*8/ GSO1O2O l2*a/ 171—4 — Magnitude of the Residue— Residue Studies for Each Food Use - I ot and Tuber Vegetable Group 10/ Potatoes Partially GS0102016* Yes 7 ! 0009550]*a/ Sugarbeets TEP Partially GS0102004* Yes 8 ! GS0102032* 48 ------- TABLE A GE ERIC DATA REX UIREMENTS FOR DISULFU1T Does EPA Have Data To Satisfy This Requir eflt? (Yes, No or partially) GS0102004* No GS0102032 Must Additional Data Be Sutinitted Bibliographic Canposition 1 / Citation Under FIFRA Section 3(c)(2)(B)? 2 / Data RequirEnent §158.125 Residue Ch nistry (continued) 171—4 — Magnitude of the Residue — Residue Studies (continued) — Leaves of I ot and Thber Vegetable Group ‘ / Sugarbeets Gs0l02 031*a/ TEP Yes - Leafy vegetable Group 11 / TEP Partially GS0102015 Yes 12 ! Lettuce Spinach TEP Partially GS0 102017 Yes’ 3 ! — Brassica (cole) Leafy Vegetable Gronp 14 ! Partially GS0 102002* GSO 10 20 18* yes 15! 16 / Broccoli TEP Brussel Sprc its TEP Partially GS0 102015 Yes’ 5 !’ 7 ! Cabbage TEP Partially GS0102002 yes l5/l 8 / Cauliflower TEP Partially GS0102015 yesl5/l 9 / 49 ------- TABLE A GENERIC DATA RE UIRE24EWI’S FOR DISULF(YI Does EPA Have Data Must Additional To Satisfy This Data Be Sutinitted Requiranent? (Yes, Data RequirGnent Cclnposition 1 / No or Partially) Bibliographic Citation Under FIFRA Section 3(c)(2)(B)? 2 / §158.125 Residue Ch nistry (cant i nued) - Legume Vegetables ( succulent or dried) Group 20/ Dried Beans TEP Yes GS0 10203 1*a/ No GS0 1020 15* Lima Beans TEP Yes GS0102031*a/ No GS O 10 20 15* Peas TEP Yes GS0102031*W No GSO 102015* Snap beans TEP Yes GS0102031*W No GSO1O2O1 5* Soybeans TEP Partially GS0102019* Yes 21 ! GSO1O2 O11* - Fol iage of Legume Vegetable Group 22 ! Bean Vines and Hay TEP Partially GS0102031*W Yes 23 ! GSO 102015* Pea Vines and Hay TEP Partially GS0102031*a/ Yes 24 ! GSO 102015* 50 ------- TABLE A GENERIC DATA RB(JIR 4ENTS FOR DISULFUIT Does EPA Have Data Must Additional To Satisfy This Data Be Sutxnitted Requirei ent? (Yes, Data Require ent Canposition’/ No or Partially) Bibliographic Citation Under FIFRA Section 3(c)(2)(B)? 2 / §158.125 Residue Chenistry (continued) Soybean Forage and Hay TEP Partially GSO1O2O11*b/ Yes 25 GS0102019* - Fruiting Vegetables Group Peppers TEP Partially GSO]02020b/ yes 26 Tonatoes TEP Partially GS0102031*W y es 27 /2 8 GS0102015* 29/ — Thee Nut Group 30 ! Pecans TEP Yes GS0 102012*b/ GS0102021* — Cereal Grains Group Barley TEP Partially GS0102031*W Yes 32 ! GS0102015* Corn TEP Partially GSO102O31* / Yes 33 ! GS0102009* GSO1O2O1O* GSO1 O2O11*b/ CS0102022* 51 ------- TABLE A GENERIC DATA REX (JIREMENIS FOR DISULF YION Does EPA Have Data Must Additional I Satisfy This Data Be Sutinitted Requir nent? (Yes, Data Requir nent Canpcsition 1 / No or Partially) Bibliographic Citation Under FIFRA Section 3(c)(2)(B)? 2 / §158.125 Residue Ch nistry (continued) Oats TEP Partially GS0102015* Yes 32 ! GS0102 031*a/ Rice TEl ’ Partially GS0102018 Yes 34 ! Sorghum TEP Partially GS0102023* yes 32 ! 33 / 3 5/ GS0102009* 36! GSO 10 203 1* a! 00095554* 00095502* Wheat TEP Partially GS0102024* yes 32 ! 3 7/ GS0102031*W GSO 10 2002* — Forage, Fodder, and Straw of Cereal Grain Group Barley, Green Fodder 38 ! TEP Partially (3 50102015* Yes 39 ! Straw GS0102031*W Corn, Fodder TEP Partially GS0102022* Yes 4 ° Forage GSO1O2O1 1*b/ GSO1O2 O1O* GS0102009* G 50102031*a/ Oat, Green Fodder 4 l/ TEP Partially Gs0102015* Yes 42 / Straw GS0102031*a! 52 ------- TABLE A GENERIC DATA RD (JIREMEN S FDR DISUUtYJX)N Does EPA Have Data Must Additional ‘lb Satisfy This Data Be Sulnitted Requir ent? (Yes, Data Requiranent Canpositicn’/ No or Partially) Bibliographic Citation Under FIFRA Section 3(c)(2)(B)? 2 / §158.125 Residue Ch nistry (continued) Rice, Straw TEP Yes GS0102018 No Sorghim , Fodder 40 ! TEP Partially GS0102023* Yes 43 ! Forage GS0102009* GSO 102031 * a/ 00095502* a/ 00095554* Wheat, Green Fodder 41 ! TEP Partially GS0102002* Yes 44 ! Straw GS0102024* GsO].02 031*a! — Non—Grass Animal Feeds ( Forage, Fodder, Straw, and Hay) Group ’ / Alfalfa TEP Partially GS0102002* Yes 46 ! Alfalfa, hay GS0102031*W 00095502* a! Clover TEP Pai±ially GS0102025 NO 46 ’ Clover, hay Asparagus TEP Partially GSO1O2O13 Yes 47 ! Coffee Beans TEP Partially GS01020l0* Yes 48 ! GSO 102008* Cotton, forage TEP Partially GS0102003* Yes 49 ! Cottonseed 00095622* 53 ------- Hops Peanuts 50 ! Peanuts, hulls Peanuts, hay Pineapple Pineapple foliage sugarcane 53 / Tbbacco TABLE A GENERIC DATA RF UIREM ’IS FOR DISULRYrON Does EPA Have Data To Satisfy This Requir ent? (Yes, No or Partially) Data Requir ent §158.125 Residue Chfflnistry (continued) Must Additional Data Be Sutinitted Bibliographic Canpositioni! Citation Under FIFRA Section 3(c)(2)(B)? 2 ! - Crops Gr n Solely for Seed Carrots Garlic Onions Radishes Dirnips TEP Yes GS0102026b/ No TEP Partially GS0102018* GS O 1020 GS 0102 03]*a/ Yes 51 ! TEP Partially GS0102018 Yes 52 ! TEP Partially GS O1O2O1O Yes 54 / TEP Partially 00002477* 00095498* Yes 55 ! TEP No — yes 56 ! TEP No — Yes 56 ! TEP No — yes 56 ’ TEP No — yes 56 ! TEP No yes S 6 ! 54 ------- TABLE A GF ERIC DP TA REX JIREMFWI’S FOR DISULFOTON Does EPA Have Data Must A ditiona1 To Satisfy This Data Be Subnitted Section Requir ent? (Yes, Data Requir nent Cciripositio&J No or partially) Bibliographic Citation Under FIFRA 3(c)(2)(B)? 2 / §158.125 Residue Ch istry (continued) 171—4 — Magnitude of the Residues in Food—Producing Animals Meat/Milk/Poultry/Eggs i 3A1 or Partially 0S0102025* Yes 57 ! plant metabolites GS0102006* 0102026 *b/ GS0102027* a! GSO1O 2030* aJ -— Post Processing Residue TGAI or No Reserved 58 ! Studies plant metabolites 55 ------- TABLE A GE 4ERIC EATA RE (JIRE21ENTS FOR DISULFtTION §158.125 Residue Ch nistry (continued) 1/ Ccrnposition= ‘IGAI= Technical grade of the active ingredient; PAIRA= Pure active ingredient, radiolabeled; TEP= Typical end—use product DEC t986 2/ Data must be subnitted no later than ________________________ 3/ Data delineating the quantification of each oxidative metalxlite present in samples of crcps representing each crcp grouping must be sutrnltted. 4/ Data delineating the quantification of oxidative metabolites present in meat, milk, poultry, and eggs must be sutmitted. 5/ a. Metaboli n studies utilizing ruminants must be subuitted. Animals must be dosed with [ 14 C] disulfoton at 12 p n in the diet for 3 days. Milk must be sampled twice daily throughout the dosing period. Animals must be sacrificed within 24 hours of the final dose and residues characterized and quantified in milk, muscle, fat, kidney, and liver. The dose should include the following metabolites in a 1:5:2:10 ratio: disulfoton sulfoxide (II), disulfoton sulfone (III), disulfoton oxygen analog sulfoxide (V), and disulfoton oxygen analog sulfoxide (V), and disulfoton oxygen analog sulfone (VI). The ratio is based on plant metabol i i studies. The animals should be sacrificed within 24 hours of the last dose. If ruminant metabolism is found to differ significantly fran that of rats (based on previously—subnitted rat metabolism studies), then non— ruminant (swine data) will be required. b. Metabolism studies utilizing poultry must be suttnitted. Animals must be dosed with E 14 C] disulfoton at 2.0 ppn in the diet for 3 days. Eggs must be sampled twice daily throughout the dosing period. Animals must be sacrificed within 24 hours of the final dose and residues characterized and quanitified in eggs, muscle, fat, gizzard, heart, liver and skin. The dose should include the same metabolites as those depicted for the ruminant study. 6/ A method must be provided which can be used without an oxidation step for the purpose of identifying and quantifying individual metabolites. 7/ Additional residue data must be sutinitted which reflects a single at—planting soil application (ground or aerial) followed by a single post ergent broadcast aerial application of a 15% G at 3 lb. a.i./A 56 ------- TABLE A GE1 ERIC DATA REXJ(JIREMENTS FOR DISULFUION §158.125 Residue Ch nistry (continued) rate. Residues must be determined 75 days after the second treatment. Tests must be conducted in Oregon and Washington. 8/ Data on residues in dehydrated sugar beet pulp, molasses, and refined sugar due to the processing of sugar beets having weathered, measurable residues must be sutmitted. 9/ A group tolerance is not appropriate at the present time because residue data are required for one additional m nber of this group (turnip leaves). 10/ A group tolerance is not appropriate at the present time because residue data are required for t additional rn bers of this group (carrots and radishes). 11/ A group tolerance is not appropriate at the present time because residue data are required for one additional m ttber of this group (celery). 12/ Additional data must be sutinitted reflecting residues in leaf and head lettuce (with and without wrapper leaves) gr n in Arizona and California (including irrigated regions) a) 60 days after an at—plant banded soil application (spring—or sinwner-seeded) of a G or EC formulation at 1.2 oz. a.i./l000 feet of r ’i (2.18 lb a.i./A with an 18 inch r spacing), and b) 60 days after a post—Energerit banded soil application (fall—or winter-seeded) as a side-dress at thinning with one G and one EC formulation at 1.2 oz a.i,/1000 rc feet (2.18 lb a.i./A with an 18—inch rc spacing.) 13/ Additional data must be sutnitted reflecting residues in or on spinach gr in in California (including irrigated regions) 42—50 days (normal harvest) after an at—plant banded soil application of a G or EC formulation at 0.6 oz a.i./l000 feet of r . 14/ A group tolerance is not appropriate at the present time because residue data are required for one additional member of this group (mustard greens). 15/ Additional residue data must be subnitted using either a G or an EC formulation as a postemergence broadcast soil application at 0.92 oz. a.i./2500 square feet in the transplant bed foll ed by a single sidedress application (broccoli) at 1.125 oz. a.i./1000 feet of rc i to established plants in the field. For brussel sprouts, cabbage, and caulif1 er, two sidedressings are necessary at above rate. 57 ------- TABLE A GE JERtC DATA REX UIREMEN1’S FOR DI JLRYI ON §158.125 Residue Ch nistry (continued) 16/ Samples should be harvested 14 days after the sidedress treatment.. Tests should be conducted In California (including irrigated regions). 17/ Samples should be harvested 30 days after the last sidedress treatment. Tests should be conducted in California (including irrigated regions). 18/ Samples should be harvested 42 days after the last sidedress treatment. Test should be conducted in California (11%), Florida (21%), New York (14%) and Texas (22%) (including irrigated regions); the percentages given for each state represent the contribution of each state to the total U.S. cabbage crop. 19/ Samples should be harvested 40 days after the last sidedress treatment. Tests should be conducted in California (including irrigated regions). 20/ A group tolerance is not apprcpriate at the present time because a) the established tolerances in or on dry beans, lime beans, snap beans, and peas are more than 5X greater than the established tolerance for soybeans; and b) the ca modity definitions for linta beans as stated in 40 CFR 180.1 (J)(8) (beans and the pod) arid for snap beans differ significantly fran those for dry beans, peas, and soybeans. 21/ Residue data on soybean hulls, soapstock, and refined oil processed fran soybeans having measurable weathered residues must be sutmitted. It may be necessary to use exaggerated rates to achieve measurable residues in the raw agricultural ca iiiodity. Should residues be found to concentrate in any of these processed products, appropriate food/feed additive tolerances must be prcposed. 22/ A group tolerance is not appropriate at the present time because the established tolerance for bean and pea vines are more than SX greater than the established tolerance for soybean forage. 23/ Additional residue data must be suth itted for bean vine hay harvested 60 days after a single post nergent soil application (double banded sidedress on each side of row after plants are established) of a registered G or EC formulation at 1.9 oz a.i. (1000 feet of row). Tests must be conducted in California, Michigan, New York, and Oregon (major U.S. growing regions for dry, snap, and lime beans). Alternatively, a label restriction may be proposed which would prohibit feeding of bean vine hay to livestock. 24/ Additional residue data must be sutuiitted for pea vine hay harvested 50 days after a simple post ergent soil application (banded sidedress after plants are established) of a registered C or EC formulation at 2.5 lb/A. 58 ------- ThBLE A GENERIC DATA REQUIRF2IENTS FOR DISULFUIt)N §158.125 Residue Chemistry (continued) Tests must be conducted in Washington and Wisonsin since these states represent the majority of crop production area for green peas for processing. Alternatively, a label restriction may be proposed which would prohibit feeding of pea vine hay to livestock. 25/ Additional residue data are required for soybean hay harvested 75 to 125 days (depending on the prefeeding restriction proposed) after an atplanting application of one of the registered G formulations at 1.2 oz a.i ./l000 feet of row. Tests must be conducted in Illinois, Minnesota, and Missouri since these states represent the major U.S. soybean production areas. Available data do indicate one of the following should be proposed for soybean forage a) a tolerance increase and a 75—day pregrazing and prefeeding restriction, or b) a 125—day pregrazirig and prefeeding restriction. Should the registrant wish to propose a tolerance increase, we recamnend a level of 2ppe , which would make the soybean forage and bean and vine tolerances ccmpatible. 26/ While the existing tolerance on peppers is based on adequate residue data, this data was generated for a soil application. However, since there are no data available to support the state labels calling for foliar (EC) applications, residue data must be sutznitted fran peppers harvested at intervals appropriate to the state labels after foliar treatment with an EC formulation at the maximum registered rate. The studies should take place in California. 27/ Additional residue data are required for tcinatoes obtained fran plants 30 days after the second of two postemergent soil applications, spaced 21 days apart, of the 61b./gal/ EC and, in a separate test, a representative G formulation at 2.4 oz a.l./1000 feet of row. The plants used in the above trial should be grown in transplant beds that were treated postemergence at 2.75 oz a.i./2500 square feet with a representative G formulation. The field studies should take place in California. 28/ Additional residue data are required for tanatoes obtained 30 days after a single, postenergence soil application of the 6 lb/gal. EC and (in a separate test) a representative G formulation at 11 oz a.i./l000 feet of row (72—inch row spacing). The plants used in the above trial should be raised in transplant beds treated postenergent at 2.75 oz a.i./2500 square feet with a representative G formulation. The field studies should take place in an alkaline soil in Florida. 29/ Residue data must be suthiitted for puree, catsup juice, wet and dry panace obtained by pra essing tcznatoes having weathered residues at or above the tolerance. This may require that the tcmatces be treated at exaggerated rates. 59 ------- TABLE A GENERIC DATA RE UIREMENIS FOR DISULRYI )N §158.125 Residue Chemistry (continued) 30/ A group tolerance is not apprcpriate at the present time because residue data are required for two additional members of this group (almond and English walnut). 31/ No additional data are required; however the existing tolerance should be decreased fran 0.75 p n to 0.1 pp in order to correspond with expected residues at the highest label rate (3 lb a.i./A)(EC); and also to achieve canpatibility with Codex MRL. 32/ Residue data are required fran the milled products of wheat grain, obtained by processing wheat grain samples containing measurable weathered residues. This may require that wheat samples be treated at exaggerated rates. This data will be translated to barley, oats, and sorghum to totally or partially fulfill the same requirements for these catinod it i es. 33/ Residue data are required fran representative processed products of field corn, including crude oil, refined oil, and milled products, and sweet corn (cannery waste) after processing corn bearing measurable weathered residues. This may require that corn samples be treated at exaggerated rates. This data will be translated to sorghum to partially fulfill the same requirement for this ccmnodity. 34/ Residue data are required f ran rice and its milling products, including polished rice, hulls, and other milled products, obtained fran rice bearing measurable weathered residues. This may require that rice be treated at exaggerated rates. 35/ Residue data are required f ran sorghum grain harvested 7 days after the second of two foliar applications, spaced three days apart, at 1 lb. a.i./A. Separate tests of aerial and ground applications should be done in Texas and Oklahcrna. 36/ Additionally, infotmation must be suth itted to indicate the rate of application in oz a.i./l000 feet of row for all soil treatments. Current label rates given as 1 lb. a.i./A may correspond to as low as 0.43 oz a.i./1000 feet of row, if a narrow (14—inch) row spacing was used, and thus the maximum or near maximum rate would not be represented by much of the data currently in the Agency files. 37/ Residue data are required fran winter wheat grain harvested 30 days after the last of the following treatments: an at—planting, fall application of the 15% G at 1 lb a.i./A followed by two foliar treatments with the 6 lb.! gal. EC at 0.75 lb. a.i./A at 30 day intervals in the fall, followed in the spring by two identical follar 60 ------- TABLE A GENERIC DATA RE) UIREMENI’S FOR DISULFUIt)N §158.125 Residue Chemistry (continued) treatments starting 90 days before expected harvest. The studies should be done in Texas, Nebraska, California, Montana, Tennessee, and New York which represent the major winter wheat production areas, as well as the various climatic regions of the U.S. Foliar treatments must be applied in separate tests using aerial and ground equip- ment. 38/ A tolerance for barley hay must be proposed, based upon the data requested in 39/• Also the ccmnodity definition “green fodder” should be changed to “forage”. 39/ Additional residue data must be sutznitted fran barley forage and hay cut 30 days after the second treatment of each of the foll ing two treatment regimes: a) a pre—ernergence soil application and a post—emergence foliar application, following as soon as is normally practiced, of the 6 lb./gal EC at 1 lb. a.i./A; b) two ground— applied, foliar treatments spaced at a practical interval, of the 6 lb./gal EC at 1 lb. a.i./A. In addition residue data fran straw cut 60 days after the former treatment regime (a) should be sut xnitted. The studies should be conducted in California, Montana, North Dakota, and Washington. 40/ Additional residue data must be sut nitted and tolerances proposed for both corn and sorghum silage. Such data should be derived for corn silage produced by ensiling corn forage bearing weathered residues at or near the 5 ppn tolerance. Exaggerated rates or early harvesting may be required to obtain such forage. If not concen- tration of residues takes place, the corn silage tolerances should be proposed at 5 p n; if concentration does occur, an appropriately higher tolerance should be recaim ended. These data will also be used to propose a tolerance for disulfoton residues in or on sorghun silage. 41/ The cx inodity definition “green fodder” should be changed to “forage”. 42/ A tolerance must be proposed for oat hay based upon data requested for wheat hay in 44/• 43/ Additional residue data must be subnitted for sorghum fodder subject to an at—plant application with a G formulation at 1.2 oz a.i./1000 row feet followed by a postenergence sidedress treatment with an EC at 0.5 lb. a.i./A followed by a postemergence sidedress treatment with an EC at 0.5 lb a.i./A followed by three aerially-applied foliar treatments with an EC at 1 lb a.i./A. Fodder should be prepared for sampling 34 days after the final treatment. Studies must be conducted in Okiahana and Texas. Residue data must also be subnitted fran sorghum fodder and forage harvested 28 days after the second of two foliar applications of an EC, spaced 3 days apart, at 0.5 lb. a.i./A. Tests should take place in Texas. 61 ------- TABLE A GENERIC DATA RE JIREMENIS FOR DISULE’OTON §158.125 Residue Ch nistry (continued) 44/ Additional residue data must be sutxnitted and tolerances proposed for both oat and wheat hay. Such data should be derived fran wheat forage, hay, and straw taken 30 days after the last of the following treatments: an at— planting, fall application with a G formulation at 1 lb. a.i./A, a broadcast application of the 0.75% G at 0.75 lb. a.i./A made when the crop is established, followed by two foliar treatments with the 6 lb/gal. EC at 0.75 lb a.i./A at 30 day intervals, followed in the spring by two identical foliar treatments starting 90 days before expected harvest. Foliar applications should be made with aerial and ground equi ment and should take place in Texas, Nebraska, California, Montana, and Tennessee, which represent the major wheat producing areas registered as use sites. 45/ A group tolerance is not appropriate at the present time because a 7—day preharvest interval (PHI) has been established for clover, whereas no PHI exists for alfalfa. Since both crops are caiinonly planted in mixtures, the disparity between PHI’s is unrealistic and must be resolved. 46/ Additional data are required which reflect residues in or on alfalfa (fresh) and alfalfa hay samples collected at 0, 7, and 14 days after the last of four broadcast applications (one at—planting and three prior to growth fran established stubble) made during one growing season. Tests should reflect use of the 15% G or the 6 lb./gal. EC formulation at 1 lb a. i ./A application in California (8%), Nebraska (6%) and Wisconsin (11%); the percent contribution to annual U.S. alfalfa production is given in parenthesis. Additional data are also being required which reflects residues in or on alfalfa hay and seed harvested 14 days after the last of four aerial and ground foliar applications with the 6 or 8 lb./gal. EC formulation at 1 lb. a.i./A. Tests should be conducted at the sites detailed above. Upon subnission of data pertaining to alfalfa seed, a tolerance for disulfoton residues in or on alfalfa seed must be proposed, if necessary. Finally, a processing study Is required to determine residues in meal processed f ran field—treated hay containing detectable, weathered residues; if residues are found to concentrate in meal, a feed additive tolerance must be proposed. The above data on alfalfa will be translated to clover. Note: Until the above data is su nitted a grazing restriction must be placed on the appropriate product labels for alfalfa hay, in addition to the existing restriction against feeding and foraging of cut green alfalfa grown for seed production. 47/ Additional residue data must be sulinitted for asparagus (fresh spears) harvested 4 months after the last of three foliar applications made at greater than 14-day intervals with the 8 lb./gal. EC formulation at 1 lb. a.i./A in the states of California and Washington. Applications must be made using ground and aerial equiçment. 62 ------- TABLE A GENERIC DATA REI )UIREMENIS FOR DISULFCIION §158.125 Residue Ch nistry (continued) 48/ Additional residue data must be sutmitted for coffee beans bearing measurable weathered residues; it may be necessaiy to use exaggerated application rates to obtain detectable residues in the green coffee beans. If residues are found to concentrate in instant coffee, a food additive tolerance must be proposed. 49/ Additional residue data must be subnitted for cottonseed and forage after the following consecutive treatments: (a) seed treatment with the 9.14 lb./gal. WIli formulation at 8 Oz. a.i./lOO lb of seed; (b) a preplant banded soil application of a registered EC formulation at 1.2 oz a.i./l,000 feet of row; (c) an at—plant band soil application of a registered G and EC formulation at 1.0 oz a.i./l,000 feet of row; and (d) two postenergent soil applications (made 21 days apart) of a registered G and EC formulation at 1.2 and 2.4 oz a.i./1,000 feet of row (G formulation at 2.4 02 rate on irrigated cotton only). Seed samples should be collected 28 days after the last postenergent treatment at 1.2 oz. a. i./l ,000 feet of row and 90 days after the last postenergent treatment at 2.4 oz./a.i./l,00 0 feet of row. Forage samples should be collected in Arizona, California, Mississippi, and Texas which together account for 80% of U.S. cotton production. Also data must be reflecting residues in or on cottonseed and forage after seed treatment with the 9.14 lb/gal. RIU formulation at 8 oz. a.i./lOO lb. of seed followed by three foliar spray applications made prior to blocin of the 6 or 8 lb/gal. EC formulation at 9 oz...a.i./A, foliar application should be made using both aerial and ground equi xnent. Cottonseed data are required only for aerially—applied treatments. Forage samples should be collected at weekly intervals throughout the growing season. Tests should be conducted in the same states noted above. Finally data must be sutmitted reflecting residues in meal, hulls, soapstock, and crude and refined oil processed fran cottonseed bearing measurable weathered residues. If residues are found to concentrate in any of these processed products, then appropriate food/feed additive tolerances must be proposed. The above required data for cottonseed forage must be accaipanied by a tolerance proposal. Alternatively, grazing and feeding restrictions may be proposed. 50/ A tolerance rnsut be proposed for peanut vines based upon data requested in 51/ below. 51/ Additional residue data must be subnitted for the .processed ccrm dlties peanut meal, crude oil, soapstock, and refined oil. The processed caruiodities must be derived fran peanuts containing detectable, field weathered residues. Additionally residue data must be sutrnitted for peanuts, peanut hulls, hay and vines reflecting one preplant, broad— 63 ------- TABLE A G ERIC DATA RE JIREM ’IS FDR DISLJLFXY N §158.125 Residue Ch nistry (continued) cast, soil—incorporated application of 6—8 lb./gal. EC formulation at 6 lb. a.i./A follcMed by two soil applications of a G or EC formulation, both early poste ergence and at—pegging at 2.25 oz. a.i./l000 feet of rc (at least 2 lb. a.i./A). 52/ Additional residue data must be suhnitted in which residues are measured in or on pineapple forage (foliage) 60 days after the last of two broadcast applications made during the same crop season with one of the G formulations at 2.5 lb. a.i./A; the final application must be applied by leaf base feeding. Tests should be conducted in Hawaii. Also required is a determination of residues in juice and bran processed frcm disulfoton — treated pineapple, bearing detectable, weathered residues. 53/ Since sugarcane forage is used for animal feed, appropriate residue data (noted below), a tolerance proposal, and a pregrazing interval proposal are required; alternatively, a feeding and grazing restriction may be proposed. 54/ Also additional data must be subnitted reflecting residues in or on sugarcane and sugarcane forage following four weekly foliar applications (both aerial— and ground—applied) of one of the registerd EC formulations at 9 oz. a.i./A. Sugarcane should be harvested 28 days after the last treatment. Forage should be sampled throughout the treatment period and at weekly interval thereafter up to 28 days. Tests should be conducted in Puerto Rico and Florida. Finally data reflecting residues in or on nolasses, refined sugar, and bagasses processed fran sugarcane bearing measurable weathered residues must be sut nitted. It may be necessary to use exaggerated application rates to achieve detectable residues in the raw agricultural cai odity. If residues are found to concentrate in any of these processed products, appropriate food/feed additive tolerance must be proposed. 55/ Additional data must be subnitted which reflects residues of disulfoton and its cholinesterase-inhibiting metabolites in or on green freshly-harvested tobacco treated with a post nergent broadcast soil application (in the transplant bed) of one the registered G formulations at 3.75 oz a.i./2,5000 square feet followed by a preplant incorporated soil application (in the field) of one of the G formulations at 6 oz. a.i./l,000 feet of row and, in separate tests, one of the registered EC formulations at 4 lb. a.i./A. If residues of >0.1 ppn are detected in the green, freshly harvested tobacco, then pyrolysis products derived fran disulfoton and its cholinesterase—inhibiting metabolites, and/or formulation impurities must be characterized and quantified. 64 ------- TABLE A GE 1ERIC DATA REX UIREMENIS FOR DISULF(YION §158.125 Residue Ch istry (continued) 56/ At the time these uses were registered, residue data was not required. Presently these uses are considered as feed uses, unless supportive residue data are available to indicate no detectable residues occur in the plants as a result of the maximum registered use rate. Since such data is not presently available, it must be sutinitted. If the data indicate residues do occur in these ccirvnodities, appropriate tolerances must be requested. 57/ The metaboli of disulfoton in animals is not adequately understood. Additional data is being requested (in 4/) to identify and quantify metabolites. Should metabolites of concern differ fran those currently sought, additional data will be required. The available data indicate the necessity of proposing tolerances for poultry at 0.01 ppn and eggs at 0.001 p in (limits for sensitivity of available methods) 58/ The requirenent for these data will be reserved, pending receipt and evaluation of the appropriate residue studies noted above. *All references must be cited a) Studies sul nitted by Ch nagro Ag. Div., Mobay Corp. These data may be canpensable. b) Studies sut nitted by Chanagro Corp. These data may be ccmpensable. 65 ------- TABLE A G ERIC DATA RFXXJIRF 4E TIS FOR DISULFtYflJN Must Additional Does EPA Have Data Data Be Suth itted Use Canposition’/ Pattern 2 ! To Satisfy This Requir nent? (Yes, No or Partially Bibliographic Citation Under FIFRA Section (c)(2)(B)? 3 / (See asterisks) Data Requir ent §158.130 Environmental Fate D XRADATION SThDIES-LAB : 161—1 — Hydrolysis Photodegradat ion 161—2 — In water 161—3 — On soil 161—4 — In Air METABOLISM SIUDI ES—LAB : 162—1 — Aerobic Soil 162—2 — Anaerobic Soil 162—3 — Anaerobic Aquatic 162—4 — Aerobic Aquatic MOBILITY SIUDIES : 163—1 — Leaching and Adsorpt ion/Desorpt ion 1GM or PAIRA A,B,C,F,G No — Yes* 1T3AI or PAIRA A,B,C,G No — Yes* IGAI or PAIRA A,C No Yes* IGAI or PAIRA A No - YeS*** 1GM or PAIRA A,B,G No Yes** 1GM or PAIRA A No Yes** 1GAI or PAIRA C,G No Yes** TGAI or PAIRA C No Yes*** IGAI or PAIRA A,B,C,G Partially 00068214W Yes 4 !* 66 ------- TABLE A GENERIC DATA REX)(JIREMENTS F DR DISULF(YI )N Must Additional Does EPA Have Data Data Be Sutinitted Use Cartposition’/ Pattern 2 ’ To Satisfy This Requirement? (Yes, No or Partially Bibliographic Citation Under FIFRA Section (c)(2)(B)? 3 / (See asterisks) Data Requirement §158.130 Environmental Fate 163—2 — Volatility (Lab) 163—3 — Volatility (Field) DISSIPATION SIUDIES-FIELD : 164—1 — Soil 164—2 — Aquatic (Sediment) 164—3 — Forestry 164—4 — Ccinbinat ion and Tank Mixes 164—5 — Soil, Long—tezm ACCUMULATION SIUDI ES : 165—1 - Rotational Crops (Confined) 165—2 — tational Crcps (Field) TEP A,G No — Yes*** TEP A,G No — Yes*** TEP A,B Partially 5 ! 00068096 b/ Yes 6 /** TEP C No - Yes*** TEP G No — Yes** — — — — Yes*** TEP A,C No — Yes*** PAIRA A,C No Yes*** TEP No Yes*** TEP C No Yes*** 165—3 — Irrigated Crops 67 ------- TABLE A GENERIC DATA REX UIREMENTS FOR DISULF Y1 JN Must Additional Does EPA Have Data Data Subnitted Use Data Require ent Canpositioni! Pattern 2 ! I Satisfy This Require ent? (Yes, No or Partially Bibliographic Citation tinder FIFRA Section (c)(2)(B)? 3 / (See asterisks) §158.130 Environmental Fate (continued) 165—4 — In Fish 1 AI or PAIRA A,C No Yes 165—5 — In Aquatic Non—Target TEP C,G No Yes Organi sns 1! Ccriposition: It AI = Technical grade of the active ingredient; PAIRA = Pure active Ingredient, radiolabelled; TEP = Typical end—use product. 2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non—Food; C=Aquatic, Food Crop; E Aguat Ic, Non—Food; E=Greenhouse, Non-Food; G=Forestry; H=Danest i c Outdoor; I=Indoor. 3/ Data must be sul:initted no later than *J e 1985, **Dac .J r 1986, 1987 . 4! Require one study of absorption/desorption on aquatic sediment, and n ,bi1ity data for disulfoton on sandy loam. 5/ Data identifies degradates sulfone and sulfoxide, but lacks information on decline of disulfoton and/or degradates. 6! Require test on representative dcmestic soil and at highest recamiended label rates. a) Studies sitinitted by Mobay Ch ica1 Corporation. These data may be canpensable. b) Studies sulxnitted by Id Pn erica, Inc. These data may be canpensable. 68 ------- Data Requir nent §158.135 Toxicology ACUTE TESTING : 81—1 — Oral — Rat 81—2 — Dermal 81—3 — Inhalation — Rat 81—7 - Acute Delayed Neurotoxicity — Hen SUBGll IC TESTING : 82—1 — 90—Day Feeding — Rodent, Non-Rodent 82—2 — 21—Day Dermal 82—3 — 90—Day Dermal TCAI T AI TCAI AI AI AI A,B,C,D,E F,G,H A,B,C,D,E, F,G,H A,B,C,D,E F,G,H A,B,C,D,E F,G,H A,C,E A,E,F,G A,E,F,G Yes Yes No No GSO1O 2 300a/ Gso]. 02300a/ No No Yes* Yes* TABLE A GENERIC DATA RD UIREMENIS FOR DISIJLF(Y1TJN Does EPA Have Data To Satisfy This Requirenent? (Yes, No or Partially Must Additional Data Be Sutrtitted Under FIFRA Section Use Ccrnposition’/ Pattern 2 ’ Bibliographic Citation (c)(2)(B)? 3 / (See asterisks) No No No Yes 4 /* yesS/* * No 6 ! 69 ------- Data Requir ent §158.135 Toxicology (continued) SUBCHRJNIC TESTING (continued) 82—4 — 90—Day Inhalation — Rat 82—5 — 90—Day Neurotoxicity- Hen/Manv a1 CH} JNIC TESTING : 83-1 — Chronic Toxicity — 2 species: Rodent and Non—rodent 83—2 — Oncogenicity Study — 2 species: Rat and Mcuse preferred 83—3 — Teratogenicity — 2 species 83—4 — Reproduction, 2—generation MUTN3ENICITY TESTING 84—2 — Gene Mutation TABLE A GENERIC DATA REX UIREMENTS DR DISOLFUJX)N Must Additional Does EPA Have Data Data Be Sutinitted Use canposition 1 / Pattern 2 ’ To Satisfy This Requir nent? (Yes, No or Partially Bibliographic Citation Under FIFRA Section (c)(2)(B)? 3 / (See asterisks) A,E,F,G No Yes 7 /** A,E,F,G No Yes 8 /** GAI AI ‘ItAI A,C,E Partially 0 0 07 33 48a/ Yes 9 /*** 1 AI A,C,E Partially GSO1O23O1W Yes 9 /**** AI A,B,C,E F,G,H,I Partially GS0102302a/ YeslO/**** ICAI A,B,C,D E , F ,G No Yes**** 1X AI A,B,C,E Partially GS0102303 70 ------- TABLE A GENERIC DATA RErUIRErVWrS R)R DISULFOION Must Additional Does EPA Have Data Data Be Sutxnitted Use Ccznpositionl/ Pattern 2 ! To Satisfy This Requirenent? (Yes, No or Partially . Bibliographic Citation Under FIFRA Section (c)(2)(B)? 3 / (See asterisks) Data Requir ient §158.135 Toxicology (continued) 84—2 — Other Mechani ns of Mutagenicity SPECIAL TESTING 85—1 — General Metaboli n 85—2 — Danestic Animal Safety — — Deiinal Absorption — — Product Integrity Studies F,G,I A,B,C,E, F,G,I MUTACENICITY TESTING (continued) 84-2 — Chranosanal Aberration 1 AI A,B,C,E, F,G,I PAl or PAIRA A,C,F,I Choice A,B No Partially 0 0 028625 b/ Partially 00083251 GSO 1 O 200 6a/ Yes 000134 R7C/ No No TEP TEP (Granular) Yesl 2 /**** Yesl 3 /**** Yesl 4 /** No yesl5/* Yesl 6 /* A,B,G A,B,C,D, E,F,G,H,I 71 ------- TABLE A G 4ERIC DATA REX (JIREME 4TS FX)R DISULFCY ON §158.135 Itxicology (continued) 1/ Canposit ion: PAl = Pure active ingredient: PAIRA = Pure active ingredient, radiolabelled; Choice = Choice of several test substances determined on a case—by--case basis. 2/ The use patterns are coded as follows: A=Terrestrial, Food Cr ; BTerrestrial, Non—Food; C—Aquatic, Food Crop; E Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; Fl=Danestic Outdoor; 1= Indoor. 3/ Data must be sutrnitted no later than *J j 1985, ** j 1985, ***Janualy 1985, ****Dc . r 1987 . 4/ Using oxidation matabolites of disulfoton. 5/ Only if worker exposure analysis indicates potential hazard of repeated exposure. 6/ The 21 day dermal study would be sufficient to assess the possible dermal exposure associated with the current pesticidal use of disulfoton. 7/ Only if worker exposure analysis indicates potential hazard of repeated exposure, and if product integrity studies indicate that respirable dust is generated during shipping and handling (see data gaps). 8/ Contingent upon the outcane of the acute delayed neurotoxicity study. 9/ Testing required in the rat. 10/ Testing required in another species (other than the rat). 11/ In vitro manmalian cell; LS178 (1K), CHO (HGPWr), or v79 (HGPRT). 12/ Sister chranatid exchange in CHO cells or human lymphocytes and dcxninant lethal. 13/ Contingent upon the outcme of 7 and 8 above. 14/ An adequate study is required to delineate the pharinacokinetic and pharmacodynamic aspect. Preferred test organism is the rat. 15/ In order to estimate toxicity which may result fran dermal exposure to the chemical or its major metabolites, an estimate of the rate of dermal penetration of these moieties must be established. Dermal uptake kinetics and excretion kinetics studies must be provided to estimate body dose at any point in time after exposure. Such studies are necessary for the risk asses nent to those occupationally or accidentally exposed dermally. 16/ A prcposed protocol is to be subnitted and approved by the Agency prior to initiating these studies. a) Studies su)xnitted by Mobay Chemical Corp. These data may be canpensable. b) Studies sutinitted by FMC Corp. These data may be canpensable. c) Studies subnitted by Chemagro Corp. These data may be canpensable. 72 ------- TABLE A GENERIC DATA RF) (JIREMENTS FOR DISULEtII’ON Data Requirenent Ccinpositionh! Use Pattern 2 ! Does EPA Have Data I D Satisfy This Requir nent? (Yes, No or Partially) Bibliographic Citation Must Additional Data Be Subnitted Under FIFRA Section 3(c)(2)(B)? 3 / §158.140 Reentry Protection TEP A,B,C,F,G No — Yes 4 / 5 / 132—1 — Foliar Dissipation 132-1 — Soil Dissipation TEP A,B,C,F,G No — Yes 4 ! 5 ! 133-3 - De ma1 Exposure TEP A,B,C,FPG No — Yes 4 / 5 ! 133—4 — Inhalation Exposure TEP A,B,C,F,G No — yes 4 /5! 1/ Canposition: TEP = Typical end—use product. 2/ The use patterns are coded as fol lc ,s: A=Terrestri al, Food Crop; B=Terrestrial, Non—Food; C=Aquat ic, Food Crop: D=Aquat Ic, Non—Food: E=Greenhouse, Food F=Gr ouse, Non—Food; G=Forestry; H=Danest i c Outdoor; 1=1 ndoor. 3/ Data must be sul itted no later than I I 4/ An interim 24 hour reentry interval is imposed for these use patterns pending the receipt and evaluation of reentry data. rkers may reenter within that interval if protective clothing is rn. 5/ Analysis of residues should include both qualitative and quantitative assays for oxidative metabolites. 73 ------- TABLE A GENERIC DATA RF (JIREMENTS FOR DISULFOITJN Does EPA Have Data Must Additional To Satisfy This Data Be SutLlnitted Use Data Require ent Ccn position 1 / Pattern 2 ! Requir nent? (Yes, No or Partially) Bibliographic Citation Under FIFRA Section 3(c)(2)(B)? 3 / §158.142 Aerial Spray Drift 201.1 — Droplet Size Spectrum Testing TEP A,B,C,D,G No Yes 202.1 — Drift Field Evaluation TEP A,B,C,D,G No Yes 1/ Ccii posit ion: TEP = Typical end-use product. 2/ The use patterns are coded as foll s: A=Terrestrial, Food Crop; Terrestrial, Non—Food; C=Aquatic, Food Crop: D=Aquat Ic, Non—Food: E=Greenhouse, Food Crc2; F=Greenhouse, Non-Feed; G=Forestry, H=Da est ic Outdoor, 1= Indoor. 3/ Data must be sutmitted no later than OLC 1986 74 ------- Data Requir ent §158.145 Wildlife and Aquatic Organ i ns AVThN AND MAMMALIAN TESTING 71—1 — Avian Oral 71—2 — Avian Dietary a—Waterf il b.Upland game 71—3 — Wild Mamal Toxicity 71-4 — Avian Repr x1uction 71—5 - Simulated and Actual Field Testing — Mamals and Birds P (JATIC O1 ANISM TESTING 72—1 — Acute Freshwater Fish a. Wanuwater TGAI A,B,G,H I GAI A,B,G,H 0006 826 8**a/ No 00003503** 0006826 8**a/ 00003503** TABLE A GENERIC D7 TA RB (JIREMENI’S FOR DI JLFO1DN Does EPA Have Data To Satisfy This Requir ent? (Yes, No or partially) Must Additional Data Be Section Use cC 1 OSitionV Pattern 2 ! Bibliographic Citation Under FIFRA 3(c)(2)(B)? 3 / I GAI A,B,G,H Yes 00095655 *a/ GS0102700* 05008363** IGAI A,B,G,H Yes 00094233 *a/ 00058746* Reserved 4 / ICAI A,B,G,H Yes 0009 4233*a! Reserved 4 ! ICAI A,G No Reserved 4 ! TGAI A ,B ,G No Reserved 5 ! TEP A Partially OOO9 5 6S8 ’ W 0009565 7**W Yes 6 ! b. Coldwater Yes Yes No 75 ------- TABLE A GF ERIC DATA REX IJIRE21EN’IS FOR DISULFtYIt)N Does EPA Have Data Must Additional To Satisfy This Data Be Sutinitted Use Data Requiranent Canposition 1 / Pattern 2 / Requirenent? (Yes, No or Partially) Bibliographic Citation Under FIFRA Section 3(c)(2)(B)? 3 / §158.145 Wildlife arid uatic Organi ns (continued) ? QUATIC OI ANISM IESTI (continued) 72—2 — Acute Freshwater Invertebrates 1 3AI A,B,G,H Partially 7 ’ 00003503** Yes 72—3 — Acute Estuarine and Marine Organi ns a. Shrimp IGAI A,B No Yes 8 ! b. Marine fish TGAI AB No Yes 8 ! c. Oyster I AI A,B No Yes 8 / 72—4 — Fish Early Life Stage and Aquatic Invertebrate Life-Cycle 1t AI A,B No Reserved 4 ! 72—5 — Fish Life—Cycle RAI A,B No Reserved 4 ! 6 / 9 ! 72-6 — Aquatic Organi n Accumulation IGAI A,B No Reserved 4 ’ 72—7 — Simulated or Actual Field Testing — Aquatic Organ i ns TEP A,B No Reserved 4 ’ 76 ------- TABLE A GENERIC DATA RE (JIREME flS RJR DIStJLRYIt N §158.145 Wildlife and Aquatic Organisi s (continued) 1/ Ccznposition: ‘IGAI — Technical grade of the active ingredient; PAT = pure active ingredient; TEP = Typical end—use product 2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; BTerrestrial, Non—Food Crop; C=Aquatic, Food Crop; D=Aquatic, Non-food; E=Greenhouse, Food Crop; F=Greenhouse, Non—Food; G=Forestry; H=Donestic Outdoor I=Indoor. 3/ Data must be submitted no later than ________________________ 4/ Reserved pending results of metaboli u data. Toxicity studies on metabolites may be required. 5/ Reserved pending indication of Environmental Fate information. 6/ Field studies are required due to the toxicity of the chemical in relation to expected environmental concentrations. At this time three field monitoring studies are required: One for the use of the 15% granular product on a crop with higher use rates, one for the use of the emulsifiable concentrate band treatment on a crop with a higher use rates and one for the broadcast foliar application. Depending on the results of studies, further testing on additional crops may be necessary. 7/ A more sensitive life stage must be tested. 8/ Disulfoton has LCSO values below 1 ppn for aquatic invertebrate and fish. Several crops are grown in excess of 300,000 acres in coastal counties. The following dlsulfotai uses meet this requirement: corn, soybean, sorghum and cotton. 9/ Reserved pending results of test 72—4. Study on its own fulfills Guideline Requirement ** Study must be canbined with other studies to fulfill Guideline Requirement. a) Studies submitted by Mobay Chemical Corp. These data may be cai pensable. 77 ------- TABLE A GE2 ERIC DATA REX UIREMENIS FOR DIStJLFtTR!4 Does EPA Have Data To Satisfy This Must Additional Data Be suth itted Use Data Require nent Canposition 1 ! Pattern 2 ! Requir nent? (Yes, No or Partially) Bibliographic Citation Under FIFRA Section 3(c)(2)(B)? §158.155 Nontarget Insect NCt T ET INSECT TESTING - POLLINNIORS : 141—1 — Honey bee acute contact I GAI A,B Yes 00066220a/ 05001991 05004151 141—2 — Honey bee — toxicity of residues on foliage TEP A,B No Yes 141-4 — Honey bee subacute feeding study (Reservedj 4 / 141—5 — Field testing for pollinators (Reserved] 4/ 142—1 — Acute toxicity to aquatic insects [ Reserved] 5/ 142—2 — Aquatic insect life-cycle study [ Reserved] 5 ! 142—3 — Simulated or actual field testing for aquatic insects [ Reserved ) 5 ! 78 ------- TABLE A GENERIC DATA REX JIREMEN1S Et)R DISULFUI JN Does EPA Have Data To Satisfy This Must Additional Data Be sutxnitted Use Data Requir nent Ccitiposition 1 / pattern2/ Requirenent? (Yes, No or Partially) Bibliographic Citation Under FIFRA Section 3(c)(2)(B)? §158.155 Nontarget Insect INSECT TESTING — POLLINATORS : 143—1 — NCNrAWET INSECT TESTINX thru PRED IORS AND PARASITES 143—3 [ Reserved) 5 ’ 1/ Canposition: U3A 1 = Technical grade of the active ingredient; TEP = Typical end—use product. 2/ The use patterns are coded as fol lows: A=Terrestrial, Food Crop; B=Terrestrial, Non—Food; C=Aquat Ic, Food Crop: D=Aquat i c, Non-Food; E=Greenhouse, Food Croj F re ) use, Non—Food; G=Forest ry; H=Danest i c Outdoor; 1=1 ndoor. 3/ Data must be sutmiitted no later than ______________________ 4/ Reserved pending developnent of test method. 5/ Reserved pending Agency decision as to whether data requir nent should be established. a) Studies sulznitted by Penick Corp. These data may be canpensable. 79 ------- TABLE B PROWC SPECIFIC DATA REXYJIREMENIS FOR MANUFACJXJRING-USE P1 )WC1’S CtNTAINII G DISULFUITJN Data Require ent §158.120 — Product Chanistry Product Identity : 61—1 — Identity of Ingredients 61—2 — Statenent of Canposition MP MP MP R R R [ x l [ Xl LX ] [ xl [ Xl [ xl [ [ 1 (1 [ 1 F] Test Substance 1 ! Guidelines Status2/ Are Data Required 3 / Yes No Footnote Ni unber MP R [ ] [ =1 M I ’ R [ X I (] t’IP R [ ] CI 61—3 — Discussion of Fonnation of Ingredients Analysis and Certification of Product Ingredients 62—1 — Preliminary Analysis 62—2 — Certification of Limits 62—3 — Analytical Methods for Enforc nent of Limits Physical and Chanical Characteristics 63—2 — Color 63—3 — Physical State’ 63—4 — Odor MI’ MI’ R R R 80 ------- TABLE B PI DDUC SPECIFIC D A RB UIREMENTS FOR MANUFACIURIM3-USE P1 Jt1JC1’S CO AINING DISULRY1t Guideline Citation and Name of Test Data Require nent §158.120 — Product Chenistry (cont’d) Physical and Chenical Characteristics (Continued) 63—7 — Density, Bulk Density, or Specific Gravity Test Substance’! Guidelines Status 2 ’ Are Data Required 3 ! Yes No Footnote Number CR MP R [ ] E_] NP R [ ] [ =1 NP [ ] NP E ] NP NP E ] E ] NP NP ( ] [ I NP E ] 63—12 — pH 63—14 — Oxidizing or Reducing Act ion LI 63—15 — Fianunability CR [ TI 63—16 — Explodability R [ I 63—17 — storage stability R 0 63—18 — Viscosity CR [ TI 63—19 — Miscibility CR [ 1 63—20 — Corrosion Characteristics R [ I Other Requ i r nents: — Subnittal of samples PA l CR 64— 1 [ I [ i:] 81 ------- TABLE B P DWC SPECIFIC DATA RE (JIREMENI’S F R MANUFACIURIt -USE P DWCTS JWTAINIt DISLJLFUI N §158.120 — Prx uct Chenistry (cont’d) 1/ Test Substance: MP= Manufacturing—use Product; PAI= Pure active ingredient; Choice= Choice of several test substances on a case-by—case basis. 2/ Guideline Status: R= Required; CR Conditionally required 3/ Data must be sutinitted t y 1985 82 ------- TABLE B PF DWCI’ SPECIFIC D A RB UIREMENIS FOR MANUFACTURING USE P1 X11CIS (fl’ffAINING DI JLFU [ ’ON Does EPA Have Data Must Additional To Satisfy This Data be Sutziutted Requir eflt? (Yes, Data Requiranent Ccznposition No or Partially) Bibliographic Citation Under FIFRA Section 3(c)(2)(B)? 1/ §158.135 Toxicology AC JTE TESTING 81—1 — Oral Granular containing 2% ai No Yes Granular containing 2.2% ai No Yes Granular containing 5% ai No Yes E nu1sifiable conc. cont. 68% ai No Yes 81—2 — Detmal Granular containing 2% ai No Yes Granular containing 2.2% ai No Yes Granular containing 5% ai No Yes E u1sifiable conc. cont. 68% ai No Yes 81—3 — Inhalation Granular containing 2% ai No Yes Granular containing 2.2% ai No Yes Granular containing 5% ai No Yes Dttulsiflable cone. cont. 68% ai No Yes 81—4 - Primary Eye Granular containing 2% ai No Yes 2 ! Irritation Granular containing 2.2% ai No Yes 2 ! Granular containing 5% ai No Yes 2 ! nu1sifiab1e conc. cont. 68% ai No Yes 2 ! 81—5 — Primary Granular containing 2% ai No Yes 2 ! Dermal Granular containing 2.2% ai No Yes 2 ! Irritation Granular containing 5% ai No Yes 2 ! E nulsifiable cone. cont. 68% ai No Yes 2 ! 81—6 — DeLma l Granular containing 2% ai No Sensitiza— Granular containing 2.2% ai No No 3 ! tion Granular containing 5% ai No N&! E)nulsifiable cone. cont. 68% ai No No 3 ! 83 ------- TABLE B P1 )WCF SPECIFIC DATA R )UIREME T S Ft)R MANUFAC11JRI USE P1 XIJCTS C T AINING DISULFUION §158.135 Tbxicology (continued) 1/ Data must be suhnitted no later than _______________________ 2/ Testing is contingent upon toxicity category as determined 1 the acute oral, detmal and inhalation toxicity. Chemicals in toxicity category I are not to be tested for their eye or deunal irritating potential. 3/ The chemical structure of disulfoton does not indicate a possible dermal sensitization potential. The inerts used in the formulations do not seen to have skin sensitization potential. 84 ------- TABLE C P WCr SPECIFIC DATA REQUIREMENTS FOR D-USE P X1JCI’S J AINING DISULF(YIt)N E ta I quirement canposition 1 / Exes EPA Have E ta 1b Satisfy This Requirement? (Yes, No or Partially) Bibliographic Citation Must Piiditional E ta be Sutmitted Under FIFRA Section 3(c)(2)(B) §158.135 PDxicology ACITrE TESTING 81—1 — Acute Oral Thxicity Rat EP No — yes / 81—2 - Acute t zTnal Ibxicity EP No — Yes 3 ’ 81—3 — Acute Inhalation 1 ’Dxicity — Rat EP No — Yes 3 ! 1/ Canpos it ion: EP = end—use product. 2/ t ta must be subnitted no later than June 1985 . 3/ (a) For new end—use granular products greater than 2.0% disulfoton. Either these data must be sut nltted and evaluated prior to registration or the products must be labeled for restricted use. (b) For currently registered end—use granular products containing greater than 2.0% disulfoton. These products must be labeled for restricted use pending receipt and evaluation of these data. (c) For new currently registered end—use granular products containing 2.0% disulfoton or less. tata must be sutznitted in order to evaluate the appropriate toxicity category and to consider the appropriateness of classifying these products for restricted use. 5. ------- IV. SUBMISSION OF REVISED LABELING INFORMATION Note : This section applies to all products containing disul foton. FIFRA requires each product to be labeled with accurate, complete and sufficient instructions and precautions, reflecting the results of data concerning the product and its ingredients. Labeling requirements are set out in 40 CFR 162.10 (see Appendix IV—1) and are summarized for products containing this active ingredient as part of this Guidance Document (See Appendix IV—2). Applications submitted in response to this notice must include draft labeling for Agency review. If you fail to submit revised labeling information complying with this section and/or Section I, EPA may issue a notice of intent to cancel the registration under FIFRA sec. 6(b)(1). A. Label Contents 40 CFR 162.10 requires that certain specific labeling statements appear at certain locations on the label. This is referred to as format labeling . Specific label items listed below are keyed to Appendix IV—2. Item 1. PRODUCT NAME — The name, brand or trademark is required to be located on the front panel, preferably centered in the upper part of the panel. The name of a product will not be accepted if it is false or misleading. Item 2. COMPANY NAME AND ADDRESS — The name and addr&ss of the registrant or distributor is required on the label. The name and address should preferably be located at the bottom of the front panel or at the end of the label text. Item 3. NET CONTENTS — A net contents statement is require on all labels or on the container of the pesticide. The preferred location is the bottom of the front panel immediately above the company name and address, or at the end of the label text. The net contents must be expressed in the largest suitable unit, e.g., “1 pound 10 ounces” rather than “26 ounces.” In addition to English units, net contents may be expressed in metric units. See Appendix IV—l. [ 40 CFR 162.10(d)] Item 4. EPA REGISTRATION NUMBER — The registration number assigned to the pesticide product must appear on the label, preceded by the phrase “EPA Registration No.,” or “EPA Reg. No.” The registration number must be set in type of a 86 ------- size and style similar to other print on that part of the label on which it appears and must run parallel to it. The registration number and the required identifying phrase must not appear in such a manner as to suggest or imply recommendation or endorsement of the product by the Agency. See Appendix IV—l. [ 40 CFR 162.10(e)] Item 5. EPA ESTABLISHMENT NUMBER — The EPA establishment number, preceded by the phrase EPA Est.” is the final estab— lishrnent at which the product was produced, and may appear in any suitable location on the label or immediate container. It must also appear on the wrapper or outside container of the package if the EPA establishment number on the immediate container cannot be clearly read through such wrapper or container. See Appendix IV—1. [ 40 CFR 162.10(f)) Item 6. INGREDIENTS STATEMENT — An ingredients statement is required on the front panel and must contain the name and percentage by weight of each active ingredient and the total percentage by weight of all inert ingredients. The preferred location is immediately below the product name. The ingredients statement must run parallel with, and be clearly distinguished from, other text on the panel. It must not be placed in the body of other text. See Appendix IV—l. [ 40 CFR 162.10(g)] Item 6A. POUNDS PER GALLON STATEMENT — For liquid agricul- tural formulations, the pounds per gallon of active ingredient must be indicated on the label. Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS — Front panel precautionary statements must be grouped together, preferably within a block outline. The table below shows the minimum’type size requirements for various size labels. Size of Label Signal Word as Re— “Keep Out of Reach on Front Panel quired Minimum Type of Children” in Square Inches Size All Capitals as Required 5 and under 6 point 6 point above 5 to 10 10 point 6 point above 10 to 15 12 point 8 point above 15 to 30 14 point 10 point over 30 18 point 12 point Item 7A. CHILD HAZARD WARNING STATEMENT — The statement “Keep Out of Reach of Children” must be located on the front panel above the signal word except where contact with children during distribution or use is unlikely. See Appendix iV—l. [ 40 CFR 162.10(h) ( 1)( ii)) Item 7B. SIGNAL WORD — The signal word (Caution, warning, or Danger) is required on the front panel immediately below the child hazard warning statement. See Appendix IV—1. [ 40CFR162.lO(h)(l)(i)] 87 ------- Item 7C. SKULL & CROSSBONES AND WORD “POISON” — On products assigned a toxicity Category I on the basis of oral, dermal, or inhalation toxicity, the word “Poison” shall appear on the label in red on a background of distinctly contrasting color and the skull and crossbones shall appear in immediate proximity to the word POISON. See Appendix 1V—l. [ 40 CFR 162.l0(h)(l)(i)] Item 7D. STATEMENT OF PRACTICAL TREATMENT - A statement of practical treatment (first aid or other) shall appear on the label of pesticide products in toxicity Categories I, II, and III. See Appendix IV—l. [ 40 CFR l62.lO(h)(l)(iii)) Item 7E. REFERRAL STATEMENT — The statement “See Side (or Back) Panel for Additional Precautionary Statements” is required on the front panel for all products, unless all required precautionary statements appear on the front panel. See Appendix IV—l. [ 40 CFR 162.l0(h)(l)(iii)] Item 8. SIDE/BACK PANEL PRECAUTIONARY LABELING — The precautionary statements as listed below must appear together on the label under the heading “PRECAUTIONARY STATEMENTS.” The preferred location is at the top of the side or back panel preceding the directions for use, and it is preferred that these statements be surrounded by a block outline. Each of the three hazard warning statements must be headed by the appropriate hazard title. See Appendix IV—l. [ 40 CFR 162.10 (h) (2)] Item 8A. HAZARD TO HUMANS AND DOMESTIC ANIMALS — Where a hazard exists to humans or domestic animals, precautionary statements are required indicating the particular hazard, the route(s) of exposure and the precautions to be taken to avoid accident, injury or damage. See Appendix IV—l. [ 40 CFR 162.10 (h)(2) (i)) Item 8B. ENVIRONMENTAL HAZARD — Where a hazard exists to non—target organisms excluding humans and domestic animals, precautionary statements are required stating the nature of the hazard and the appropriate precautions to avoid potential accident, injury, or damage. See Appendix IV—l. [ 40 CFR 162.10(h) (2) (ii)] Item BC. PHYSICAL OR CHEMICAL HAZARD 1. Flammability statement . Precautionary statements relating to flammability of a product are required to appear on the label if it meets the criteria in Appendix IV—3. The require- ment is based on the results of the flashpoint determinations and flame extension tests required to be submitted for all products. These statements are to be located in the side/back panel precautionary statements section, preceded by the heading SiPhysical/Chemical Hazards.” Note that no signal word is used in conjunction with the flammability statements. 88 ------- 2. Criteria for declaration of non—flammability . The following criteria will be used to determine if a product is non—flammable: a. A “non—flammable gas” is a gas (or mixture of gases) that will not ignite when a lighted match is placed against the open cylinder valve. b. A “non—flammable liquid” is one having a flashpoint greater than 350°F (177°C). C. A non—flauunable aerosol” is one which meets the following criteria: i. The flame extension is zero inches; ii. There is no flashback; and iii. The flashpoint of the non—volatile liquid component is greater than 350°F (177°C). 3. Declaration of non—flammability . Products which meet the criteria for non—flammability specified above may bear the notation “non—flammable” or “non- flammable (gas, liquid, etc.)” on the label. It may appear as a substatement to the ingredients statement, or on a back or side panel, but shall not be highlighted or emphasized (as with an inordinately large type size) in any way that may detract from precaution. 4. Other physical/chemical hazard statements . When chemistry data demonstrate hazards of a physical or chemical nature other than flammability, appropriate statements of hazard will be prescribed. Such statements may address hazards of explosivity, oxidizing or reducing capability, or mixing with other substances to produce toxic fumes. Item 9 . PRODUCT CLASSIFICATION — Section 3(d) of FIFRA requires that all pesticide formulations/uses be classified for either general or restricted use, and that those uses classified as restricted be limited to use by certified applicators or persons under their direct supervision (or subject to other restrictions that may be imposed by regulation). In the Registration Standard, the Agency has (1) indicated certain formulations/USeS to be restricted, based either on a previous classification determination made through the optional procedures of 40 CFR 162.30 or based on data already available to the Agency, or (2) reserved any classification decision until appropriate data are submitted. 89 ------- The Regulatory Position and Rationale states whether products containing this active ingredient are classified for restricted use. If they are restricted the draft label(s) submitted to the Agency as part of your application must reflect this determination (see below). If you wish to propose that your product should not be classified for restricted use, you must submit any information and rationale with your application for reregistration. During the Agency’s review of your application, your proposed classification determination will be evaluated in accordance with the provisions of 40 CFR 162.11(c). You will be notified of the Agency’s classification decision. A. Classification Labeling Requirements 1. All Uses Restricted — Pesticide products bearing directions for use for formulations or uses classified restricted shall bear statements of restricted use classi- fication on the front panel as described below: a. The statement “RESTRICTED USE PESTICIDE,” must appear at the top of the front panel of the label, set in type of the same minimum sizes as required for human hazard signal words (see table in 40 CFR 162.l0(h)(l)(jv). b. Directly below this statement on the front panel, a summary statement of the terms of restric- tion shall appear. If use is restricted to certified applicators, the following statement is required: “For retail sale to and use only by Certified App1 cators or persons under their direct supervision and only for those uses covered by the Certified Applicator’s Certification.” 2. Some But Not all Uses Restricted — If the Regula- tory Position and Rationale states that some uses are classified for restricted use and some uses are unclassified, several courses of action are available: a. You may label the product for restricted use. If you do so, you may include those uses that are unrestricted, but you may not distinguish them on the label as being unrestricted. b. You may delete all restricted uses from your label and submit draft labeling bearing only unres- tricted uses. 90 ------- c. You may “split” your registration, i.e., register t separate products with identical formula- tions, one containing only unrestricted uses, and the other restricted uses. 1’D do so, subnit t applications for reregistration, each containing all forms and necessary labels. th applications should be sul:initted simultaneously. Note that the product names will be assigned separate registration nutibers. B. Canpliance Schedules No product with a use classified for restricted use under this Standard may be released for shipnent by the registrant or producer after September 1, 1985, without bearing the restricted use classification. All products still in channels of trade after September 1, 1986, must be labeled for restricted use. Item 1OA. SIORN E AND DISPOSAL BLOCK - All labels are required to bear storage and disposal statements. These stat nts are developed for specific containers, sizes, and chemical content. These instructions must be grouped and appear under the heading “Storage and Disposal” in the directions for use. This heading must be set in the same type sizes as required for the child hazard warning. Refer to Appendix Iv—4 to determine the disposal instructions appropriate for your products. Item lOB. DIRECTIONS FOR USE - Directions for use must be stated in terms which can be easily read and understood by the average person likely to use or to supervise the use of the pesticide. 4ien follo d, directions must be adequate to protect the public fran fraud and fran personal injury and to prevent unreasonable adverse effects on the envi rorment • See Appendix P1—1. [ 40 CFR 162.10] B. ( Yllateral Labeling Bulletins, leaflets, circulars, brochures, data sheets, flyers, or other graphic printed matter which is referred to on the label or which is to accanpany the product are termed collateral labeling. Such labeling may not bear claims or representations that differ in substance fran those accepted in connection with registration of the product. It should be made part of the response to this notice and sulmiitted for review. 91 ------- V. INSTRUCTIONS FOR SUBMISSION All applications prepared in response to this Notice should be addressed as follows: George T. LaRocca Product Manager (15) Registration Division (TS—767C) Office of Pesticide Programs Environmental Protection Agency Washington, D.C. 20460 Phone No. (703) 557—2400 For each product for which continued registration is desired: A. For Manufacturing Products (MP) containing only disulfoton as an active ingredient. 1. Within 90 days from receipt of this document, you must submit the “FIFRA Section 3(c)(2)(B) Summary Sheet” EPA Form 8580—1. Refer to Appendix 11—3 with appropriate attachments. 2. Within 6 months from receipt of this document you must submit: a. Confidential Statement of Formula, EPA Form 8570—4. b. Product Specific Data Report, EPA Form 8580—4 (Appendix 111—1). c. Two copies of any required product—specific da ta. d. Two copies of draft labeling, including the label and associated brochures. If current labeling conforms to the requirements of this guidance document and the results of the short—term data, you may submit such labeling. End use product labeling must comply specif- ically with the instructions in Section II (Regulatory Position and Rationale) of this guidance document. The labeling should be either typewritten text on 8—1/2 x 11 inch paper or a mockup of the labeling suitable for storage in 8—1/2 x 11 inch files. The draft label must indicate the intended colors of the final label, clear indication of the front panel label, and the intended type sizes of the text. e. Evidence of compliance with data support requirements of FIFRA sec. 3(c)(l)(D). Refer to PR Notice 84—4 (enclosed) for latest requirements. 3. Within the times set forth in Table A , all generic data must be submitted. 92 ------- Note : If for any reason any required test is delayed or aborted so that meeting the agreed submission time will be delayed, notify the Product Manager. B. For Manufacturing Use Products containing Disulfoton in combination with other active ingredients. 1. Within 90 days from receipt of this document, you must submit the •‘FIFRA Section 3(c)(2)(B) Summary Sheet” EPA Form 8580—1. Refer to Appendix 11—3 with appropriate attachments. 2. Within the times set forth in Table A , all generic data must be submitted. Note : If for any reason any required test is delayed or aborted so that meeting the agreed submission time will be delayed, notifiy the Product Manager. C. For End Use products containing disulfoton alone or in combination with other active ingredients: 1. Within 90 days from receipt of this document, you must submit the “FIFRA Section 3(c)(2)(B) Summary Sheet” EPA For 8580—1. Refer to Appendix 11—3 with appropriate attachments. 2. Within 6 months from receipt of this document you must s u bm i t: a. Confidential Statement of Formula, EPA Form 8570—4. b. Product Specific Data Report, EPA Form 8580—4 (Appendix 111—1). c. Two copies of any required product—specific data. (Refer to Table C) d. Two copies of draft labeling, including the label and associated brochures. If current labeling conforms to the requirements of this guidance document and the results of the short—term data, you may submit such labeling. End use product labeling must comply specif- ically with the instructions in Section II (Regulatory Position and Rationale) of this guidance document. The labeling should be either typewritten text on 8—1/2 x 11 inch paper or a mockup of the labeling suitable for storage in 8—1/2 x 11 inch files. The draft label must indicate the intended colors of the final label, 93 ------- clear indication of the front panel label, and the intended type sizes of the text. e. Evidence of compliance with data support requirements of FIFRA sec. 3(c)(l)(D). Refer to PR Notice 84—4 (enclosed) for latest requirements. 3. For those end use product registrations that are not eligible for the formulations exemption [ FIFRA sec. 3(c)(2)(D)], submit all generic data within the time set forth in Table A. 94 ------- Appendix It—i Guide to Use of This Bibliography 1. XX9TE T OF BIBLIOGRAPHY. This bibliography contains citations of all studies considered relevant by EPA in arriving at the posit ions and conclusions stated elsewhere in the Standard. Primary sources for studies in this bibliography have been the body of data suirtitted to EPA and its predecessor agencies in support of past regulatory decisions. Selections fra n other sources including the published literature, in those instances where they have been considered, will be included. 2. UNITS OF ENrRY. The unit of entry in this bibliography is called a “study.” In the case of published materials, this corresponds closely to an article. In the case of unpublished materials sulnitted to the Agency, the Agency has sought to identify documents at a level parallel to the published article fra n within the typically larger volumes in which they were sut nitted. The resulting “studies” generally have a distinct title (or at least a single subject), can stand alone for purposes of review, and can be described with a conventional bibliographic citation. The Agency has att npted also to unite basic documents and caiinentaries upon then, treating thai as a single study. 3. IE NTIFICATION OF ENTRIES. The entries in this bibliography are sorted numerically by “Master Record Identifier,” or MRID, number. This number is unique to the citation, and should be used at any time specific reference is required. It is not related to the six—digit “Accession Number” which has been used to identify volumes of sul itted studies; see paragraph 4(d)(4) below for a further explana- tion. In a few cases, entries added to the bibliography late in the review may be preceded by a nine—character t nporary identifier. These entries are listed after all MRID entries. This t nporary identifier number is also to be used whenever specific reference is needed. 4. FDRM OF ENTRY. In addition to the Master Record Identifier (MRID), each entry consists of a citation containing standard el ents followed, in the case of material sut nitted to EPA, by a description of the earliest known sutknission. Bibliographic conventions used reflect the standards of the American National Standards Institute (ANSI), expanded to provide for certain special needs. ------- Appendix 11—1 (continued) a. Author. Whenever the Agency could confidently identify one, the Agency has chosen to show a personal author. When no individual was identified, the Agency has s} in an identifiable laboratory or testing facility as author. As a last resort, the Agency has st own the first suhuitter as author. b. i cument [ ate. When the date appears as four digits with no question marks, the Agency took It directly fran the doc ment. When a four—digit date is foll d by a question mark, the bibliographer deduced the date fran evidence in the document. When the date appears as (19??), the Agency was unable to determine or estimate the date of the document. c. Title. In sane cases, it has been necessary for Agency bibliographers to create or enhance a doci.ment title. Any such editorial insertions are contained between square brackets. d. Trailing Parentheses. For studies suhnitted to the Agency in the past, the trailing parentheses include (in addition to any self—explanatory text) the fol- lowing elements describing the earliest known sutinissiori: (1) Su znission I te. The date of the earliest known su1 ission appears ii mediately following the word “received.” (2) Administrative Number. The next el ent, inunediately following the word “under,” is the registration number, experimental use permit number, petition number, or other administrative number associated with the earliest known subuission. (3) SuLiuitter. The third el nent is the sutinitter, following the phrase “sutinitted by.” When authorship is defaulted to the sutinitter, this ela nent is cinitted. (4) Volume Identification (Accession Numbers). The final el nent in the trailing parentheses identifies the EPA accession number of the volume in which the original sutinission of the study appears. The six-digit accession number follows the symbol “CDL,” standing for “Canpany I ta Library.” This accession number is in turn followed by an alphabetic suffix which shows the relative position of the study within the volume. For example, within accession number 123456, the first study would be 123456—A; the second, 123456— B; the 26th, l23456—Z; and the 27th, 123456—AA. ------- Appendix 11—1 OFFICE OF PESTICIDE P1 XRAMS PEGISTRATIC STANDARD BIBLICX3RAPHY Citations Considered to be Part of the Data Base Supportieg Registrations Under the Disulfoton Standard 00002477 Eli Lilly arid Canpany (1972) Isopropalin—Tobacco: Isopropalin as a Herbicide for Tobacco in Cathination with Diazinon, Di—Syston, arid Prophos. Includes undated method entitled: The determina- tion of Disyston, Diazinon and Mclap in tobacco plants; Method no. 5801590 dated Jan 20, 1970 entitled: Determination of can- pound EL—179 (2,6—Dinitro-N,N—diprcpylcurnidine) in agricultural crops. (Unpublished study received Apr 2, 1973 under 1471—79; prepared in cooperation with WARF Institute, Inc., sutinitted by Elanco Products Co., Div. of Eli Lilly and Co., Indianapolis, md.; (I)L:101603—A) 00003503 Johnson, W.W.; Finley, M.T. (1980) Handbook of Acute Toxicity of Chemicals to Fish and Aquatic Invertebrates, U.S. Dept. of the Interior, Fish and Wildlife Service, Resorce Publication 137: p. 34 00013487 McCarty, R.T.; Haufler, M.; Osborn, M.G.; et al. (1969) Oral toxic- ity of Four Organophosphate Insecticides to Farm Livestock. M rican Journal of Veterinary Research 30(7):1149—1153. (Re- port no. 25425; also in unpublished sutxnission received May 3, 1971 under 1F1166; sutinitted by Chemagro Corp., Kansas City, Mo.; CDL:090961—K) 00028625 Sininon, V.F. (1979) In vitro Microbiological Mutagenicity and Un- scheduled LX A Synthesis Studies of Eighteen Pesticides: Report No. EPA—600/l—79—04l. (Unpublished study includieg sutinitter suninary, received Apr 3, 1980 under 279—2712; prepared by SRt International, subnitted by FMC Corp., Philadelphia, Pa. ; CDL: 099350—A) 00028780 Loeffler, W.W. (1970) A Confirmatory Gas Chrcinatographic Procedure for Di—syston Residue Analysis for Tobacco: Report No. 27714. (Unpublished study received Jan 25, 1974 under 3125—279; sutinit— ted by Mobay Chemical Corp., Kansas City, Mo.; CDL:102112—F) 00032409 Kiigeinagi, U.; Wellman, D.; Terriere, L.C. (1968) Residues of Di— sulfoton and Its Metabolites in Fresh and Dry Hops: Report No. 24098. (Unpublished study received Aug 8, 1969 under OF0866; prepared by Oregon State Univ., Dept. of Agricultural Chemistry, sutmitted by Mobay Chemical Corp., Kansas City, Mo.; CDL :093163—C) ------- Appendix II—]. OFFICE OF PESTICIDE P1 XRAMS J GISTRATION STANDARD BI BLICXRAPHY Citations Considered to be Part of the Data Base Supporting Registrations Under the Disulfoton Standard 00041055 Thornton, J.S. (1967) Determination of Di—Syston Residues in Vari- ous Crops and Products: Report No. 21319 • Method dated Oct 27, 1967. (Unpublished study received Oct 23, 1976 under 3125—252, subnitted by Mthay Ch ical Corp., Kansas City, Mo.; C DL: 095937—F) 00058746 Heath, R.G.; Spann, J.W.; Hill, E.F.; et al. (1972) Canparative Dietary Toxicities of Pesticides to Birds. By U.S. Fish and Wildlife Service, Patuxent Wildlife Research Center. Washing- ton, D.C.: USFWS. (Special scientific report—wildlife no. 152; sut xnitter report no. 33423; available fran: U.S. Governrr nt Printing Office: 1972 0—460—531, published study; ( DL: 224691—v) 00066220 Atkins, E.L., Jr.; Anderson, L.D.; Kellum, D.; et al. (1976) Protecting Honey Bees fran Pesticides. ?: Univ. of California, Div. of Agricultural Sciences. (Leaflet 2883; also in unpub- lished sub nission received Mar 20, 1980 under 432—502; sub- mitted by Penick Corp., Lyndhurst, N.J.; (DL:243536—B) 00068096 Suett, D.L. (1975) Persistence and degradation of Chlorfenvinphos, Chlormephos, Disulfoton, Phorate and Pirii iphos—ethyl following spring and late—sun ner soil application. Pesticide Science 6: 385—393. (Also in unpublished sutinission received Dec 17, 1976 under 10182—9; sutxnitted by ICI Americas, Inc., Wilmingtbn, Del.; CDL:2273].4—O) 00068214 Thornton, J.S.; Hurley, J.B.; Obrist, J.J. (1976) Soil Thin—layer Mobility of Twenty Four Pesticide Ch nicals: Report No. 51016. (Unpublished study received Jul 11, 1977 under 3125—315; subnit— ted by Mobay Chanical Corp., Kansas City, Mo.; CDL:230908—I) 00068268 Lamb, D.W.; Roney, D.J. (1972) Acute Toxicity of Di—syston Technical, Di—syston 15% Granular and Di—syston 6 lbs/gal Spray Concentrate to Bluegill and Rainbow Trout: Report No. 34931. (Unpublished study received Sep 13, 1977 under 3125—183; sub- mitted by Mobay Ch nica1 Corp., Kansas City, Mo.; (DL:23185l-A) 00071233 Anderson, C.A. (1962) Colorimetric Determination of Di—syston and Systox Residues in Plant Material: Report No. 8544. (Unpub- lished study received Feb 4, 1962 under PP0331; sut nitted by Mobay ChBnical Corp., Kansas City, Mo.; O)L:099937—A) ------- Appendix 11—1 OFFICE OF PESTICIDE P XRAMS REXISTRATICt STANDARD BIBLIOGRAPHY Citations Considered to be Part of the Data Base Supporting R istrations Under the Disulfoton Standard 00071237 Anderson, C.A. (1961) Colorimetric Determination of Di—syston Residues in Plant Material: Report No. 6684. Method dated Jun 2, 1961. (Unpublished study received Feb 4, 1962 under PP0331; subTlitted by Mc ay Ch nical Corp., Kansas City, Mo.; (DL: 099937—E) 00071243 Anderson, C.A. (1960) Colorimetric Determination of Di—syston and Systox Residues in Plant Material: II. Application to Potatoes, Sugar Beets, Sugar Beet Tops, Cabbage, Broccoli, Pineapple, and Alfalfa: Report No. 5511. Method dated Jul 25, 1960. (Unriib- lished study received Jan 5, 1961 under PP0256; sutxnitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:099938—F) 00071245 Razzell, W.E.; Clark, T.P. (1959) A Cholinesterase Assay for De— termining Residual Insecticides: Report No. 5165. Method dated Mar 1959. (Unpublished study received Jan 5, 1961 under PP0256; prepared by British Columbia Research Council, Div. of Chemistry, subnitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:099938—H) 00071767 Metcalf, R.L.; Fukuto, T.R.; March, R.B. (1957) Plant metaboliem of dithio-systox and thimet. Journal of Econa ic Entanology 50(3):338—345. (Also in unpublished sutinission received Apr 28, 1960 under 24l—EX—18; suth itted by American Cyanamid Co., Princeton, N.J.; ( DL:123098—A) 00073348 Hoffmann, K.; Weischer, C.H.; Luckhaus, G.; et al. (1975) S 276 (Disulfoton) Chronic Toxicity Study on Dogs (T -year Feeding Experiment): Report No. 5618; Report No. 45287. (Unpublished study received Dec 15, 1976 under 3125—58; prepared by Bayer, PC, W. Germany, sutinitted by Mobay Chemical Corp., Kansas City, Mo.; DL:095640—N) 00083251 March, R.B.; Fukuto, T.R.; Metcalf, R.L. (1957?) Metaboli n of P32—Dithio-systox in the White Mouse and American Cockroach: SuI:xnitter * 1830. (Unpublished study received on unkn in date under PP0244; prepared by Univ. of California—Riverside, Citrus Experiment Station, sutxnitted by Chemagro Corp., Kansas City, Mo.; CDL:098725—F) 00089403 Metcalf, R.L.; Reynolds, H.T.; Winton, M.; et al. (1959) Effects of temperature and plant species upon the rates of metabolism of systemically applied Di—syston. Journal of Econanic Entanology 52(3):435—439. (Suhnitter 3635: also in unpublished sutTnission received Aug 15, 1960 under PP0244; sutinitted by Mcbay Chemical Corp., Kansas City, Mo.; CDL:090271—P) ------- Appendix 11—1 OFFICE OF PESTICIDE P1 XRAMS 1 XISTRATIC STANDARD BIBLICCRAPHY Citations Considered to be Part of the Data Base Supportirx3 Registrations Under the Disulfoton Standard 00094233 Lamb, D.W.; Jones, R.E. (1973) Toxicity of (R) Dasanit—IR) Di— syston and Dasanit-Tilliam to Bobwhite Quail and Mallard Ducks: Report No. 38462. (Unpublished study received Jan 25, 1974 under 3125—252; sut znitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:02581].—F) 00095498 Mcbay Chemical Corporation (1970) Synopsis of Analytical, Residue, and Flavor Information on Di—syston Broadcast Application. In- cludes method dated Oct 27, 1967. Stminary of studies 238287—E, 090533—N and 006061—C through 006061—F. (Canpilation; unpib— lished study received Aug 19, 1970 under 3125—119; CDL:005820—A) 00095501 Mobay Chemical Corporation (1970) Synopsis of Analytical and Residue Information on Di—syston Foliar Applications to Pota- toes. Includes method dated Oct 27, 1967. (Canpilation; un- published study received Aug 9, 1970 under 3125—119; ( DL: 005873—A) 00095502 Mcbay Chemical Corporation (1971) Synopsis of Analytical and Residue Information on Di—syston Application to Alfalfa Seed, Peanuts and Sorghum. Includes method dated Oct 27, 1967. (CaTI- pilation; unpublished study received Nov 30, 1971 under 3125— 61; (I)L:006002—A) 00095554 Mcbay Chemical Corporation (1968) (R) Di—syston: Analytical and Residue Information (Corn and Sorghum). (Ccrnpilation; unpib- lished study received Mar 7, 1968 under 8F0734; CDL:091267—A; 101728; 101727) 00095622 Mobay Chemical Corporation (1969) Synopsis of Analytical and Res- idue Information on Di—syston Foliar Spray Application to Cot- ton. Includes method dated Oct 27, 1967. (Canpilation; un- published study received Feb 3, 1969 under 3125—119; ( DL: 101732—A) 00095655 Shellenberger, T.E. (1969) Letter sent to D.L. Nelson dated Aug 11, 1969: Acute Toxicological Evaluations of Di—syston with Adult Bobwhite Quail: GSRI Project No. NC—30l; 25525. Final rept. (Unpublished study received Mar 19, 1971 under unknown adrnin. no.; prepared by Gulf South Research Institute, suI nitted by Mobay Chemical Corp., Kansas City, Mo.; CDL:128228—A) ------- Appendix 11—1 OFFICE OF PESTICIDE P1 X3RA? tS 1 XI STRATION STANDARD BIBLICX RAPHY Citations Considered to be Part of the Data Base Supportirr3 Registrations Under the Disulfoton Standard 00095657 Lamb, D.W.; Nelson, D.L. (1971) Toxicity of (R) Di—syston 15% Granular on Sorghum to Juvenile Bcbwhite Quail under Simulated Field Conditions: Report No. 31135. (Unpublished study received Nov 30, 1971 under unknown admin. ro.; sutTuitted by Mt)ay Che n- ical Corp., Kansas City, Mo.; CDL:128321—A) 00095658 Lamib, D.W.; Nelson, D.L. (1971) Toxicity of (R) Di—syston Spray Concentrate to Juvenile Bobwhite Quail and New Zealand Rabbits under Simulated Field Conditions: Report No. 31235. (Unpub- lished study received Nov 30, 1971 under unknown admin. no.; sut nitted by Mobay Chemical Corp., Kansas City, Mo.; ( DL: 128321—B) 00095664 Shaw, H.R., II (1975) The Metabolism of Di—Syston in Soil: Report No. 40234. Rev. (Unpublished study received May 23, 1974 under 3125—183; sutrrtitted by Mobay Chanical Corp., Kansas City, Mo., DL:234065—A) 05001991 Stevenson, J.H. (1978) The acute toxicity of unformulated pesticides to worker honey bees (Apis mellifera—L). Plant Pathology 27(1) :38—40. 05004151 Stevenson, J.H. (1968) Laboratory studies on the acute contact and oral toxicities of insecticide to honeybees. Annals of Applied Biology 6l(3):467—472. 05008363 Hudson, R.H.; Haegele, M.A.; Tucker, R.K. (1979) Acute oral and percutaneous toxicity of pesticides to mallards: correlations with mammalian toxicity data. Toxicology and Applied Pharinacology 47 (3) :451—460. ------- Appendix ri—i OFFICE OF PESTICIDE PR)GRAMS 1 XISTRATION STANDARD BI BLICX3RApHy Citations Considered to be Part of the Data Base Supportiri Registrations Under the Disulfoton Standard GSO1O2001 Bull, D.L. (1965) Metabolism of Di—Syston by Insects, Isolated Cotton Leaves, and Rats • JQJrnai of Ecx)nanic EntaTology 58(2): 249—254 0i02002 Carter, W.; Gortner, W.A. (1958) The Translocatjon of Radioactive (S 35 ) Bayer 19639 in Pinnneapple Plants. Journal of Econcmic Entarology 51(6): 905907. (Also in unpublished study received Decather 2 1960 under petition 0282; suFi itted by Ch nagro Corp., Kansas City, MO; I B 113818) GS0102003 Che agro Corporation (1959) [ Residue Data on Cotton Leaves and Seed] (Canpilation; unpublished study received on January 19, 1961 under PPO291; RCB: 113864—5 GS0102004 Metcalf, R.L.; Fukuto, T.R.; March, R.B. (1957) Plant Metabolism of Dithiosystox and Thimet. Journal of Econanic Entarology 50(3): 338—345. (Also in unpublished study received Feb. 18, 1960 under petition 0244; sutmitted by Ch agro Corp., Kansas City, MO; RCB: 113667 GSO1O200S Ridgway, R.L.; Lindquist, D.A.; Bull, D.L. (1965) Effect of Method of Application on Uptake of Di-Syston by the Cotton Plant. Journal of Econanic Entaiology 58(2): 349—352 GSO1O2006 Puhi, R.J.; Fredrickson, D.R. (1975) The Metabolism and Excretion of Di—Syston by Rats. (Unpublished study received on Dec. 15, 1976 under 7Fl895; sutinitted by Ch nagro Agricultural Division, Mobay Corp., Kansas City, MD; CDL: 095638) GSO1O2007 Cavagnol, J.C. (1972) Analytical Studies of Di—Syston Formulations J DAC 55(5): 918—922 ------- Appendix It—i OFFICE OF PESTICIDE P} )GRAMS REXIISTRATIa J STANDP RD BIBLIOGRAPHY Citations Considered to be Part of the Data Base Supporting Registrations tinder the Disulfoton Standard GS0102008 Chen ro Corp. (1962) Colorimetric Method for the Determination of of Di—Syston Residues in Green Coffee Beans. (Unpublished study received on July 26, 1962 under pp0372; Report No. 9533 by C.A. Anderson CS0102009 Ch nagro Corp. (1967) A Study of Possible Interference of Other Pesticides with the Analytical Method for Di—Syston—Systox on Crops. Report No. 21606 by JS Thornton. (Unpublished study received July 9, 1968 under 8F0734; CDL:1l5654) GSO1O2O1O Ch iiagro Corp. (1967) Determination of Di—Syston Residues in Corn, Soybeans, Sugarcane, and Sugarcane Product by Thermiionic E nission Gas Chranatography. Report No. 20109 by J.S. Thornton. (Unpublished Study received Nov. 9, 1966 under 7F0547; CDL: 114838) GSO1O2O11 Ch nagro Corp. (1968) Determination of Dasanit Residues in Peanuts by Therinionic E idssion Gas Chranatography. Report No. 23037 by T.J. Olson. (Unpublished study received Oct. 23, 1975 under 6F1694; CDL: 116208) GS0102012 Chanagro Corp. (1970) An Interference Study on Di—Syston Pesidue Determination of Alfalfa, Clover, and Potatoes. Report No. 27312 by T.J. Olson. (Unpublished study received July 20, 1976 under 6F1835; CDL: 095330) GS0102013 Interregional Research Project No. 4 (1982) Petition for Tolerance for Use in Asparagus Product (PR—1650) Rutgers Univ. New Brunswick, N.J., received July 28, 1982 under 2E2730. GS0102014 Talbott, T.D. (1972) S iiiautanated Analysis of Granular Organophosphorous Pesticide Formulations. Journal Agric. Food ChEn. 20(5): 959—963 GSO1O2O15 Ch nagro Corp. (1961) Stability of Di—Syston Residues During Frozen Storage. 1 port No. 7147. (Unpublished study received Sept. 18, 1961 under petition 0331; RCB: 114010 ------- Appendix 11—1 OFFICE OF PESTICIDE P} JGRAMS REGISTRATION ST NflRD BIBLIOGRAPHY Citat ions Considered to be Part of the Data Base Supporting Registrations Under the Disulfoton Standard GS0102016 Cha agro Corp. (1960) [ Residue Data on Potatoes) (Canpilation; unpublished study received May 11, 1960 under pp 0256; RCB: 113714—5) GSO1O2O17 Ch nagro Corp. 1962 [ Residue Data on Pineapple, Rice, Rice, Straw, Spinach, and Peanuts] (Canpilation: unpublished study received February 12, 1962 under pp 0350: RCB: 114092) GS0102018 Chenagro Corp. (1962) [ Residue Data Concerning Alfalfa, Broccoli, and wheat] (Canpilation: unpublished study received on April 19, 1962 under pp0358: RCB: 114113) GS0102019 Chanagro Corp. (1968) [ Petition for fllerance of Di—Syston in or on Soybeans] (Canpilat ion: unpublished study received under 8F0624; RCB: 115149 and 115152) GS0102020 Chemagro Corp. (1970) [ Petition for Tolerance of Di—Syston in or on Peppers) (Canpilation: unpublished study received February 18, 1970 under 0F0945; 1 B: 116528) GS0102021 Chemagro Corp. (1966) [ Residue Data Concerning Pecans) (Canpilation: unpublished study received February 25, 1966 under 6FV478; RCB: 114554) GS0102022 Chemagro Corp. (1965) [ Residue Data Concerning Corn) (Ccxnpilation: unpublished study received March 15, 1965 under SF0443; RCB: 114427) GS0102023 Chanagro Corp. (1969) [ Residue Data concerning Sorghum Grain) (Canpilation: unpublished study received February 27, 1969 under 9F0808; RCB: 115959) GS0102024 Chenagro Corp. (1968) [ Petition to Amend Tolerance on Wheat) (Canpilation: unpublished study received February 19, 1968 under 8F0707; RCB: 115546) ------- Appendix 11—1 OFFICE OF PESTICIDE PI )GRAMS REGISTRATION STANDARD BIBLIOGRAPHY Citations Considered to be Part of the Data Base Supporting Registrations Under the Disulfoton Standard GS0102025 Chemagro Corp. (1966) [ Residue Data Concerning Clover (green and hay)] (Ccinpilation: unpublished study received March 4, 1966 under 6F0480; RCB: 114566—7) GS0102026 Kiigenagi, V; Wellamn, D.; Terrier, L.C. (1968) Residues of Disulfoton and Its Metabolites in Fresh and Dry Hops. Report No. 24098. (Unpublished study received Aug. 15, 1979 under 0F0866: sut itted by Chemagro Corp., Kansas City, MO; RCB: 116208) GS0102027 Thornton, 3.S. (1976) Effect of Feeding Di—Syston Metabolites to Dairy Cattle, Report No. 49100. (Unpublished study received Dec. 15, 1976 under 7F1895: suL itted by Mobay Chemical Corp., Kansas City, MO; CDL: 095639) GS0102028 Gunderson, E.L. (1982) Di—Syston Canpliance and Surveillance Residue Occurrences. (Unpublished study sutinitted under FDA cover letter dated May 20, 1982; on file in 7F1895 GS0102029 Gunderson, E.L. (1984) Suimiary of Disulfoton and Related Residue Findings FY 78—83 (Unpublished study sut nitted under FDA cover letter dated March 30, 1984; on file in 7F1895. GS0102030 Thornton, J.S.; Fredrickson, D.R. (1975) Effects of Feeding Di—Syston Metabolites to Chickens. Report No. 4561 (Unpublished study received Dec. 15, 1976 under 7F1895; sut:xnitted by Mobay Chemical Corp., Kansas City, MO; CDL: 095638 GS0102031 Mobay Chemical Corp. (1976) [ Petition for Tolerance of Di—Syston in or on Alfalfa (Green & Hay), Barley (Green Fodder & Straw), Beans (Vines), Clover (Green & Hay), Corn (Forage & Fodder), Meat, Fat, and Meat Byproducts of Cattle, Goats, Hogs, Horses, and Sheep, Milk, Oats (Green Fodder & Straw), Pea (Vines), Sorghui (Forage & Fodder), Sugar Beets (Tops), Wheat (Green Fodder & Straw) (Canpilation: unpublished study received Dec. 15, 1976 under 7F1895; CDL: 006002, 097270, 095637) ------- Appendix 11—1 OFFICE OF PESTICIDE P1 JGRAMS REXISTRATIC STANDARD BIBLIOGRAPHY Citations Considered to be Part of the Data Base Supporting Registrations Under the Disulfoton Standard GS0102032 Chemagro Corporation (1960) Residue and Toxicology Data on Sugar Beets (Unpublished study received February 8, 1960 under PP0244; } B 113667 GS0102300 Mjhail, F. (1978) S 276 (Disulfoton) Acute Toxicity Studies, Report 7602a prepared by Bayer, A , Institut fur Toxikologie. Unpublished study received June 12, 1978. Sutinitted by Mobay Chemical Corp., Kansas City, MO. GS0102301 Hayes, R.H. (1983). Oncogenicity Study of Disulfoton Technical in Mice. (Unpublished report of study No. 80—271—04 prepared by the Corporate Toxicology Department Mobay Chemical Corp.; submitted by Mobay Chemical Corp., Kansas City, MO. GS0102302 Lamb, D.W.; Nixson, E.J. (1983) E mbryotoxic and Teratogenic Effects of Disulfoton. (Unpublished study Report No. 81—611—02 received July 13, 1983; sul:xnitted by Mobay Chemical Corp., Kansas City, MO; CDL: 250706 GS0102303 Hanna, PJ.,; Dyer, K.F. (1975) Mutagenicity of Organophosphorus Canpounds in Bacteria and Drosophila: Mutation Research 28:405—420 G50102700 Hill, E.F. (1983) Acute Toxicity of Granular Insecticide to Bobwhite. Final Report No. IP 3 14—16—0009—82—1830. Patuxent Wildlife , Research Center Laurel, MD ------- .4i = -Z v 1 No. 2C O.O I £ # T4i- J * R1G S7 A? N MC. FIFRA SZCI1CN 3(C (23 (B) StMMARV S 1EET C UC 4AM5 t. I41 IAM1 1JlCAN M T W)mi rn rns r w an ü i d by !F A ‘i 3( Z(3) nn a thi fiii. .- 1 I i. i in a asy frnio.m r am it i I • from (ar ru na IW Gw ar rn ..‘ru j ‘n n rna Exu.r G* u rni c anu a OE 3 ‘ g T q Pru is& e. r wi . . I ‘ d1 :2. I buv .mui U USTrM un, in m w ar 1FRA on , ——- Ths 4 any r w rg 4z I bs A y: - 4AM OP QT) RE 7RAI(r L..2. I a c a MU1l A iit In O e af Ozin rrn i a fuUa nq I r a a ame iuy by a4aui Jawin ‘ t i ua n n m an a rn u’ ari aru : C £ I w ry = *Ia = rt t iL w. af in atn t .a . (Thu c ‘a ____ r e u.* iio. ------- CM8 Annvnii M . 0211P1C.21ION OP 4 rr!Mpr T ENT2 R !N AN a ierr wrr OTHEB REGSTRAJ(T 7i L_’ f . CR DE E .CPMedT OF OA?A 1. I gn uv wmw z s f dcw fIrm4s) wno in s r wi. a a MG unbar F!FRA ivn i j (3) n ni in a Gw C gi rt 1= f S U Sr lCA .c c M*wr Ara , . I D* tfY P4% Z rr iiii cr uo aT ? r,p ia U ?‘Iv m ”.3 2. M nn wdflnq u’ qg mU QIITt s da r wria y Mc . if — -- • 4Cl .11 .1f . rrvy Iinn wcugd ifl r in ui e a.....it wv ns cr enut a z èou auiuy, r s a st m. iJnwing r uw C I5 ‘ lmt in an ajr,.m..... . C siis a? a aff,rzg, irr j rtt an u’ n an aftir m uwv an im ItfiI C a1d t 4L.ifi 4 es f dawu firmisè as s t ia q ‘: . 4AM OP PM OP OFI ean r’rrnis, a ta , v F q 4. M firm r u iat EPA nat .nc s reg zantz a? ny tlrm’s crac iJ. if any r a firme nani.c in araqr1cn i3) acov nave ai e s.acrr7tt ?I lis a in an . ricn 2) accw in zraanas ‘j,r . 4ctras. I snc.retanc EPA vi*I rem imar n ma m am.r my 1rm mu a orm ivoig an on a? i te crna .mcar A $ac cn 3lc (2)(Sh Th,m ann err c n at acary 1ccu n rar I zve EPA m a cn ianasa ia s me ej re zj t tAMI I 414 I I I — ------- Appendix 111—1 P WCr SPECIFIC DATA REPORT EPA Registration No. Guidance Document for Date I f gistration Guideline No. Name of Test Test not required for my product listed above (check be1c ) I am canplying with data requir nents by 1 (For EPA Use Only) Accession Numbers Assigned Citing MRID# Sut xnit- ting Data (At— tached) §158.20 icr Q EMISTRY 61—1 Identity of ingredients 61—2 Stat nent of canpos it ion 61—3 Discussion of formation of ingredients 62—1 Preliminary analysis 62—2 Certification of limits 62—3 Analytical methods for enforcEnent limits 63—2 Color 63—3 Physical state 63—4 Odor _______ 63—5 Melting point 63—6 Boiling point 63—7 Density, bulk— density, or specific gravity 63—8 Solubility 63—9 Vapor pressure 63—10 Dissociation constant 63—11 Octanol/water partition coefficient 63—12 63—13 Stability 63—14 Oxidizing/reducing reaction 63—15 F1an nabi1ity 63—16 Explodability 63—17 Storage stability 63—18 Viscosity 63—19 Miscibility ------- Corrosion Characteristics 63—20 63—21 Dielectric break— I d n_ 1tage I S158. 135 ioxiaxe - 81—1 Acute oral LD-50, rat 81—2 Acute dermal LD—50 81—3 Acute inhalation, LC—50 rat 81—4 Primaxy eye irritation, rabbit 81—5 Primary dermal irritation 81—6 Dermal sensitiza- tion ------- APPENDIX IV—2 LAI3ELINU 1td 2 ThN1b ui iiit . FIFRA, AS AMENDED (REFER 1D ThE SAMPLE LABELS EDLIOWING) ITE 4 LABEL ELE 4E}1T APPLICABILITY OF R JIREMENT PLACE 4ENr ON LABEL (X)MMFNIS REX (JIRED PREFERRED 1. Product name All products Front panel Center front panel 2 Canpany name and address All products None Bottcin front panel or end of label text If registrant is not the producer, must he qualified by “Packed for . . .,“ “Distributed by. . .,“ etc. 3 Net: contents All products None Rottan front panel or end of_label_text —- May be in metric units in addition to U.S. units 4 EPA Est. No. All products None Front panel Must be in similar type size and run parallel to other type. 5 EPA Reg. No. All products None Front panel, inmediatel.y before or following Reg._No. May appear on the container instead of the label. 6A Ingredients statement All products Front panel Inmediately following product_name Text must run parallel with other text on the panel. 6B Pounds/gallon statement Liquid products where dosage given as lbs. ai/unit area Front panel Directly below the main ingredients statement 7 Front panel precautionary statements All products Front panel All front panel precautionary statements must be grouped together, preferably blocked. 7A 7B Keep Out of Reach of Children (Child hazard warning) Signal word All products All products Front panel Front panel Above signal word Ininediately below child Note type size requirements. - Note type size requirements. hazard warning ------- APPE JDIX P1-2 (continued) ITF 4 1 LABEL ELE 4ENT 1 APPLICABILITY OF RE)Q(JIREMENF PLcE 1E7rr ON LABEL or)MMENrS REX)(JIRED PREFERRED 7C Skull & cross— bones and word POISON (in red) All products which are Cat- egory I based on oral, der— mal, or inhala— tion_toxicity Front panel Both in close proximity to signal word 7D Statement of practical treatment All products in Categories I, II, and III Category I: Front panel unless refer- ral statement is used. Others; Grouped with side panel precautionary statements. Front panel for all. 7E Referral statement All products where pre- cautionary labe 11 ng appears on other than front_panel. Front panel 8 Side/back panel precautionary statements All products None Top or side of back panel preceding directions for use Must be grouped under the headings in HA, 813, and BC; preferably blocked. 8A Hazards to humans and danestic anima is All products in Categories I, II, and III None Same as above Must be preceded by appropriate signal word. 8B Environmental hazards All products None Same as above Environmental hazards include bee caution where applicable. ------- APPE 9DIX P /—2 (continued) II 1 LABEL ELE7IENF 1 APPLICABILflY OF R XJIR }1EN PLACf 74ENT ON LABEL — REOUIRED PREFERRED 8C Physical or chemical hazards All pressurized products, others with flash points under 150° F None Same as above (DMMENFS 9A Restricted block All restricted products Top center of front panel Preferably blocked Includes a statement of the terme of - restriction. The words “ RIC1’ED USE PESTICIDE” must be same type size as 9C Misuse statement All products Inmediately following statement of classifica- tion or ahead of directions for use signal word. 1OA Re—entry statement All cholinesterase inhibitors In the directions for use Ininediately after misuse statement 1OC Storage and disposal block All products In the directions for use Inmediate ly before specific directions for use or at the end of directions for use Must be set apart and clearly distin— guishable fr-cm frau other directions for use. 1OD U.S. Directions for use All products None None May be in metric as well as U.S. units ------- Appendix IV—3 PHYSICAL-CHEMICAL HAZARDS Criteria Required Label Statement I. Pressurized Containers A. F].ashpoint at or below 20°F; or if there is a flashback at any valve opening. B. Flashpoint above 20°F and not over 80°F; or if the flame extension is more than 18 inches long at a distance of 6 inches from the valve opening. C. ALL OTHER PRESSURIZED CONTAINERS II. Non—Pressurized Containers A. Flashpoint at or below 20° F. B. Flashpoint above 20°F and over 80°F. C. Flashpoint over 80°F and not over 150°F. D. Flashpoint above 150°F. Extremely flammable. Contents under pressure. Keep away from fire, sparks, and heated surfaces. Do not puncture or incinerate container. Exposure to temperatures above 130°F may cause bursting. Flammable. Contents under pressure. Keep away from heat, sparks, and flame. Do not puncture or incinerate container. Exposure to temperatures above 130°F may cause bursting. Contents under pressure. Do not use or store near heat or open flame. Do not puncture or incinerate container. Exposure to temperatures above 1 0°F may cause bursting. Extremely flammable. Keep away from fire, sparks, and heated surfaces. Flammable. Keep away from heat and open flame. Do not use or store near heat and open flame. None required. ------- Appendix IV—5 STORAGE AND DISPOSAL INSTRUCTIONS FOR PESTICIDES All products are required to bear specific label instructions about storage and disposal. Storage and disposal instructions must be grouped together in the directions for use portion of the label under the heading STORAGE AND DISPOSAL. Products intended solely for domestic use need not include the heading “STORAGE AND DISPOSAL.” The STORAGE AND DISPOSAL heading must appear in the minimum type size listed below: Required type size 1 Size of label for the heading front panel in STORAGE AND DISPOSAL square inches (all capitals) 10 and under . . . . . . . . . . . . . . .6 point Above 10 to 15 . . . . . . . . . . . . . .8 point Above 15 to 30 . . . . . . . . . . . . . 10 point Over 30. . . . . . . . . . . . . . . . . 12 point I I Storage and disposal instructions must be set apart and clearly distinguishable from other directions for use. Blocking storage and disposal statements with a solid line is suggested as a means of increasing their prominence. A. Storage Instruc i : All product labels are required to have appropriate storage instructions. Specific storage instructions are not prescribed. Each registrant must develop his own storage instructions, considering, when applicable, the following factors: 1. Conditions of storage that might alter the composition or usefulness of the pesticide. Examples could be temperature extremes, excessive moisture or humidity, heat, sunlight, friction, or contaminating substances or media. 2. Physical requirements of storage which might adversely affect the container of the product and its ability to continue to function properly. Requirements might include positioning of the container in storage, storage or damage due to stacking, penetration of moisture, and ability to withstand shock or friction. 3. Specifications for handling the pesticide container, including movement of container within the storage area, proper opening and closing procedures (particularly for opened containers), and measures to minimize exposure while opening or closing container. ------- Appendix IV—5 (continued) 4. Instructions on what to do if the container is damaged in any way, or if the pesticide is leaking or has been spilled, and precautions to minimize exposure if damage occurs. 5. General precautions concerning locked storage, storage in original container only, and separation of pesticides during storage to prevent cross—contamination of other pesticides, fertilizer, food, and feed. 6. General storage instructions for household products should emphasize storage in original container and placement in locked storage areas. B. Pesticide Disposal Instructions : The label of all products, except those intended solely for domestic use, must bear explicit instructions about pesticide disposal. The statements listed below contain the exact wording that must appear on the label of these products: 1. The labels of all products, except domestfc use, must contain the statement, “Do not contaminate water, food, or feed by storage or disposal.” 2. Except those products intended solely for domestic use, the labels of all products that contain active ingredients appearing on the “Acutely Hazardous” Commercial Pestic ide Products List (RCRA “E” List) at the end of this appendix or are assigned to Toxicity Category I on the basis of oral or dermal toxicity, skin or eye irritation potential, or Toxicity Category I or II on the basis of acute inhala- tion toxicity must bear the following pesticide disposal statement: “Pesticide wastes are acutely hazardous. Improper dis- posal of excess pesticide, spray mixture, or ririsate is a violation of Federal Law. If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous Waste representative at the nearest EPA Regional Office for guidance.” The labels of all products, except those intended for domestic use, containing active or inert ingredients that appear on the “Toxic” Commercial Pesticide Products List (RCRA “F” List) at the end of this appendix or presently meet any of the criteria in Subpart C, 40 CFR 261 for a hazardous waste must bear the following pesticide disposal statement: ------- Appendix IV-5 (continued) “Pesticide wastes are toxic. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of Federal Law. If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous Waste representative at the nearest EPA Regional Office for guidance.” Labels for all other products, except those intended for domestic use, must bear the following pesticide disposal statement: “Wastes resulting from the use of this product may be disposed of on site or at an approved waste disposal facility.” 3. Products intended for domestic use only must bear the following disposal statement: “Securely wrap original container in several layers of newspaper and discard in trash.” C. Container Disposal Instructions The label of each product must bear container disposaL instructions appropriate to the type of container. 1. All products intended for domestic use must bear one of the following container disposal statements: Container TvDe Statement FNon—aerosoi products 1 J(bottles, cans, jars) Do not reuse container (bottle, can, jar). I Rinse thoroughly before discarding in trash. Non—aerosol products (bags) Do not reuse bag. Discard bag in trash. I Aerosol products I Replace cap and discard containers in trash. Do not incinerate or puncture. 2. The labels for all other products must bear container disposal instructions, based on container type, listed below: Statement Container Type Metal Triple rinse (or equivalent). Then offer I J containers for recycling or reconditioning, or puncture I J(non—aerosol) and dispose of in a sanitary landfill, or by j other procedures approved by state and local authorities. Plastic containers Triple rinse (or equivalent). Then offer for recycling or reconditioning, or puncture I and dispose of in a sanitary landfill, or incineration, or, if allowed by state and local authorities, by burning. If burned, stay out of smoke. Glass containers Triple rinse (or equivalent). Then dispose of in a sanitary landfill or by other approved state and local procedures. ------- Appendix IV—5 (continued) C äiüpIétely empty liner by shaking and tapping sides and bottom to loosen clinging particles. Empty residue into application equipment. Then dispose of liner in a sanitary landfill or by incineration if allowed by state and local authorities. If drum is contaminated and cannot be reused 1 , dispose of in the same manner. Paper and plastic bags ______________________ Completely empty bag into application equipment. Then dispose of empty bag in a sanitary landfill or by incineration, or, if allowed by State and local authorities, by burning. If burned, stay out of smoke. Compressed gas cylinders Return empty cylinder for reuse (or similar wording). lManufacturer may replace this phrase with one indicating whether and how fiber drum may be reused. 2. The labels for all other products must bear container disposal instructions, based on container type, listed on the first page of this Appendix. rther drums with liners Container Type Statement ------- Appendix IV—5 (continued) Pesticides that are hazardous wastes under 40 CFR 261.33(e) and (f) when discarded. “ Acutely Hazardous” Commercial Pesticides (RCRA “E” List) Active Ingredients, (no inerts) : Acrolein Aldicarb Aidrirt Allyl alcohol Aluminum phosphide 4—Aminopyridine Arsenic acid Arsenic pentoxide Arsenic trioxide Calcium cyanide Carbon disulfide p—Chloroanil me Cyanides (soluble cyanide salts, not specified elsewere) Cyanogen chloride 2—Cyclohexyl—4 ,6—dinitrophenol Dieldrin 0,0—Diethyl S—(2—ethylthio)ethylj phosphorodi hioate (disulfoton, Di—Syston) 0,0—Diethyl 0—pyrazinyl phosphorothioate (Zinophos) Dimethoate O,O—Diinethyl O—p—nitrophenyl phosphorothioate (methyl parathion) 4,6—Dinitro—o—cresol and salts 4 ,6—Dinitro—o-cyclohexy].phenol 2,4 Dinitrophenol Dinoseb Endosulfan Endothall End r in Famphur Fluoroacetamide Heptachior Hexanethyl tetraphosphate Hydrocyanic acid Hydrogen cyanide Methomyl alpha—Naphthylthiourea (ANTU) Nicotine and salts Octamethylpyrophosphoramide (OMPA, schradan) Parathion ------- Appendix P1-5 (continued) “ Acutely Hazardous” Commercial Pesticides (RCRA “E” List) Active Ingredients continued : Phenylmercuric acetate (PMA) Phorate Potassium cyanide Propargyl alcohol Sodium azide Sodium cyanide Sodium fluoroacetate Strychnine and salts O,O,O,O—Tetraethyl dithiopyrophosphate (su].fotepp) Tetraethyl pyrophosphate Thallium sulfate Thiofanox Toxaphene Warfarin Zinc phosphide There are currently no inert ingredients for commercial pesticides on the “Acutely Hazardous” List (RCRA “E ” List). ------- Appendix IV—5 (continued) “ Toxic” Commercial Pesticide Products (RCRA “F” List) Active Ingredients : Acetone Acrylonitrile Am it role Benzene Bis( 2—ethylhexyl)pthalate Cacodylic acid Carbon tetrachioride Chioral (hydrate) Chiordane (technical) Chlorobenzene 4—Chloro-m—creso]. Chloroform o—Chlorophenol 4—Chloro—o—toluidine hydrochloride Creosote Cresylic acid Cyclohexane Decachlorooctahydro—l,3,4—metheno—2H—cyclobuta [ c,d]_penta len_2_one (kepone, chlordecone) 1, 2—Dibromo-3—chloropropane (DBCP) Dibutyl phthalate - S—3,3—(Dichloroallyl. diisopropylthiocarbamate (dia].late, Avadex) o—Dichlorobenzene p—Dichlorobenzene Dichiorodifluoromethane (Freon 12®) 3 ,5—Dichloro—N—(l,l—dimethy].—2—propynyl) benzamide (pronarnide,Kerb) Dichioro diphenyl dichioroethane (DOD) Dichioro diphenyl trichioroethane (DDT) Dichiorethyl ether 2,4—Dichiorophenoxyacetic, esters and salts (2.4—D) 1, 2—Dichioropropane l,3—Dichloropropane (Telone) Dimethyl phthalate Ethyl acetate Ethyl 4,4’—dichlorobenzilate (chlorobenzilate) Ethylene dibromide (EDB) Ethylene dichioride Ethylene oxide Formaldehyde Furfural Hexachlorobenzene Hexachiorocyclopentad iene Hexachloroe thane Hydrofluoric acid ------- Appendix IV—5 (continued) “ Toxic Commercial pesticide Products (RCRA F” List) Active Ingredients : Isobutyl alcohol Lead acetate Lindafle Maleic hydrazide Mercury Methyl alcohol Methyl bromide Methyl chloride 2,21 —Methyleflebis (3,4,6_trichlOrOPherlOl) (hexachiOrOphene) Methylene chloride Methyl ethyl ketone 4_Methyl_2 —Pefltaflofle (methyl isobutyl ketone) Naphthalene NitrobeflZefle p—Ni tropheriol pentachiorOethafle pentachlorOflitr0befl2 (PCNB) pentacloropheflol phenol PhosphorOdithiOic acid, 0,0—diethyl, methyl ester Propylene dichioride Pyridine ResorC inol Saf role Selenium disulfide Silvex 1,2 , 4 , 5_TetraChiOrObefizene 1, 1,2 , 2_TetrachiOroethafle TetrachioroethY lene 2 , 3 , 4, 6_TetraChlOropheflol Thiram Toluefle 1,1, 1_TrichiOroethafle TrichlOrOethYlefle Trich1OrOmOflOf1U0r0 t 1 (Freon ll) 2,4, 5_TrichlOrOpheflol 2,4 ,6_TrichlOrOPheflol 2,4,5_TrichlOrOPheflOXYaC5t acid (2,4,5T) Xy 1 e ne ------- Appendix IV—5 (continued) UToxicft Commercial Pesticide Products (RCRA “F” List) Inert Ingredients : Acetone Formaldehyde Acetonjtrj le Formic acid Acetophenone Isobutyl alcohol Acrylic acid Meleic anhydride Aniline Methyl alcohol (methanol) Benzene Methyl ethyl ketone Chlorobenzene Methyl methacrylate Chloroform Naphthalene Cyclohexane Saccharin and salts Cyclohexanone Thiourea Dichlorodjfluoromethane (Freon 12®) Toluene Diethyl phthalate l,l,l—Trichloroethane Dimethylamine 1,1, 2—Trichioroethane Dimethyl phthalate Trichiorofluoromethane (Freon li®) 1,4—Dioxane Vinyl chloride Ethylene oxide Xylene ------- |