Case Number 102
GUIDANCE FOR THE
REREGISTRATION OF MANUFACTURING-USE
AND CERTAIN END-USE PESTICIDE PRODUCTS
CONTAINING
DISULFOTON
(032501)
CAS 298-04-4
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. 20460
DECEMBER, 1984
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Workgroup
Robert O’Brien
Bill Boodee
Dave Brassard
George Chali
Tom Parshley
Hudson Boyd
Ed Fite
John Tice
(BUD/PQUA)
(RCB)
(BUD/INDEX)
(TOX)
(RD)
(EAB)
(EEB)
(SIS/HED)
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TABLE OF CONTENTS
I ntroduction . . . . . . . . • , . . • • • • • • • • • 1
i. Regulatory Position. . . . . . . . . . . . . . . . . . 4
ii. Requirement for Submission of Generic Data . . . 40
iii. Requirement for Submission of Product—Specific
Data S S I S S S
iv. Submission of Revised Labeling and Packaging
Information. • . . 86
A. Label Contents . . . . . . . . 86
1. Product Name • • • • • • . . • 86
2. Company Name and Address . . . . . . . . . . . 86
3. Net Contents . . . . . . . . . . . . . . . . . 86
4. Product Registration Number. . . . . . . . . . 86
5. Producing Establishment
Registration Number. . . . . . . . . . • . . . 87
6A Ingredient Statement . . . . . . . . . • . . . 87
6B pounds Per Gallon Statement. . . 87
7. Front Panel Precautionary Statements . . . . . 7E
7A Child Hazard Warning Statements. . . . • . . . 87
7B Signal Word. . . . . . . . . . . . . . . . . . 87
7C Skull and Crossbones and Word Poison . . . . . 88
7D Statement of Practical Treatment . . . • . . . 88
7E Referral Statement . . . . . . . 88
8. Side/Back Panel Precautionary Labeling . . . . 88
8A Hazard to Humans and Domestic Animals. . . . . 88
8B Environmental Hazard . . . . . . . . . . . . . 88
8C Physical or Chemical Hazard. . . . . . . . . . 88
9. Product Classification . . . . . . . . . . . . 89
10. Misuse Statement . . . . . . . . . . . . . . . 91
hA Storage and Disposal Block . . . . . . . . . . 91
I1B Directions for Use . . . . . . . . . . . . . . 91
B. Collateral Information . . . . . . . . . . . . . . 91
V. Instructions for Submission. . . . . . . . . . . . . . 92
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APPENDICES
Bibliography •..............................S..... li—i
FIFRA §3(c)(2)(B) Summary Sheet —
EPA Form 8580—1 .. ..... 11—2
Certification of Attempt to Enter Into an
Agreement With Other Registrants for Development
of Data EPA Form 8580—6 •. .. . . ............. .... .. 11—3
Product Specific Data Report (End—Use Products)... 111—1
Sample Label Formats . . . . . . . . . . . . . . . . . . . . . . . . . . . . IV—1
Table of Labeling Requirements ......... .......... Iv—2
Physical/Chemical Hazards Labeling Statement ..... IV—3
Storage and Disposal Instructions................. IV—5
Note: Appendices IV—4 and IV—6 are not germane to this
document and are not included.
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INTRODUCTION
The Federal Insecticide, Fungicide, and Rodenticide Act
(FIFRA sec. 3(g), as amended in 1978, directs EPA to reregister
all pesticides as expeditiously as possible. Each registrant
of a manufacturing use product (MP) containing disulfoton as the
sole active ingredient who wishes to continue to sell or distribute
that product must apply for reregistration under and fulfill the
requirements described in this standard.
Although the full requirements for reregistration do not
apply to other products containing disulfoton at this time,
registrants with such products are subject to various provisions
of this standard as follows. Each registrant of a MP containing
disulfoton in combination with other active ingredients is required
to comply with the data requirements set forth in Table A and B
of their documents, labeling revisions and reregistration are not
required at this time. Each registrant of an end use product (EP)
containing disulfoton as a sole active ingredient or in combination
with other active ingredients are subject to the labeling and data
requirements (refer to Table C) in this standard.
To carry out the task of reregistration, we have established
the Registration Standards program, which will review all pesti-
cide active ingredients first registered before January 1, 1977.
These pesticides will be reviewed in use clusters which are
prioritized on the basis of a ranking scheme giving preference
to pesticides used on food and feed crops.
The Registration Standards program involves a thorough
review of the scientific data base underlying pesticide
registrations and an identification of essential but missing
studies which may not have been required when the product
was initially registered or studies that are now considered
insufficient. Our reassessment results in the development
of a regulatory position, contained in this document, on
each pesticide and its uses. Based on the regulatory position,
the Agency may require the registrant to modify product
labels to provide additional precautionary statements, restrict
the use of the pesticide to certified applicators, provide
reentry intervals, modify uses or formulation types, specify
certain packaging limitations, or other requirements to
assure that proper use of the pesticide poses no potential
adverse effects to human health or the environment.
The scientific review, which is not contained in this
Guidance Package but is available upon request, concentrates
on the technical grade of the active ingredient and identifies
missing generic data. However, during the review of these
data we are also looking for potential hazards that may he
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associated with the formulated (end use) products that contain
the active ingredient. If we find serious concerns, we will bring
formulated products under the provisions of the Registration
Standards program to the extent necessary to protect the public.
EPA has the authority under FIFRA §3(c)(2)(B) to require
that registrants submit data that will answer our questions
regarding the hazard that may result from the intended use
of the pesticide under review. Further, §3(c)(2)(B) provides
that these data are to be submitted by those registrants
who do not qualify for the formulator’s exemption EFIFRA
§3(c)(2)(D)J . Normally, this means that the registrants who
are responsible for filling the data gaps are the manufacturing
use product producers (basic suppliers of the active ingredient).
However, end use producers will not qualify for the formulator’s
exemption if the source of their active ingredient: (1) is
not registered with EPA, and/or (2) is produced by the regis-
trant’s firm, or a firm which has ownership in common with
the registrant’s firm. These end use producers can qualify
for the formulator’s exemption if they change their source of
supply to a registered source, provided the source does not
share ownership in common with the registrant’s firm. If the
end use product registrant decides to switch sources, a new
Confidential Statement of Formula, EPA Form 8570—4, must be
submitted to the appropriate Product Manager within 90 days
of receipt of this Guidance Document. The chart on the
following page shows what is generally required of those who
do and do not qualify for the formulator’s exemption in the
Registration Standards program.
If you decide to request the Agency to cancel the regis-
tration of any of your products subject to the reregistration
requirements of this Guidance Document, please notify the Product
Manager named in the cover letter, within 90 days from the
receipt of this document, that you wish to voluntarily cancel
the registration(s) . If you decide to maintain your product
registration(s), you must provide the information described in
the following pages within the timeframes outlined. EPA will
issue a notice of intent to cancel or suspend the registration
of any currently registered product if you fail to comply
with the requirements set forth in this Guidance Document.
You are reminded that FIFRA sec. 6(a)(2) requires you at
any time to submit factual information raising concerns of
possible unreasonable adverse effects of a pesticide. You
should notify the Agency of interim results of studies in
progress if those results show possible adverse effects.
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PE JWCTS SUBJECr ‘10 ThE
REGI RATION SIANE1 IRLS P1 )GBAM
ACTIC14( S) REY UIRED 10
M1 I AIN REGISTRATION
I. Products That 1X Not Qualify
For The Formulator’s Exemption
A. Single Active Ingredient
ProduCts*
SI•• .•• . •I•• ••I •I •• •e•• •..
B. Multiple Active Ingredient
Products
These products must be reregis—
tered. 1 obtain reregistration,
labeling, packaging and data
requir nents must be satisfied
in accordance with the Regis-
trat ion Standards Guidance
DDc ment.
S..... SS•SI
These products will not be
reregistered at this tine.
However, generic data required
to continue the registration of
the active ingredient under
review, as described in the
Registration Standards Guidance
Dcun nt, will be required and
sate labeling precautions may
also be required.
II. Products That DD Qualify For
The Formulator’s Exemption
In the case of this standard
that requires restrictions
and labeling to protect man and
the envirorment, these products
are subject to certain
provisions in this Registration
Standard. Affected products
are to be called in as provided
for in this docurtent.
* E id use products of registrants who also produce a manufacturing
use product will not be required to be reregistered provided that
registrant fulfills the requir tents specified in the Guidance
I)Dcl ntent for manufacturing use product(s). Such end use products
will be subject to the labeling changes required for products in “ii
above. If there are no manufacturing use products registered by any
canpany end use products will be required to be reregistered, that is
neet the full data requirenents, labeling requirements, (as appropri-
ate) and 3(c)(l)(D) requirements imposed by this docunent.
NOlE: If all registrants in “I” above fail to meet the requir rents in
I—A and B above, then the registrants in NIlU lose their right to
qualify for the formulator’s exemption and becane sub)ect to the
requirements in I—A and B.
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I. Regulatory Position
A. Introduction
This Registration Standard describes the regulatory
position of the Environmental Protection Agency (EPA) on
manufacturing—use products (MUP’s) and certain end—use
products (EUP’s) containing the insecticide disulfoton as a
sole active ingredient. The Agency’s position is based on
an evaluation of all registered uses of disulfoton and registered
MUP’s with disulfoton as an active ingredient.
This document provides the rationale for the Agency’s
position and the criteria for registration that result from
it. It also discusses labeling requirements and tolerances.
Finally, it considers Special Local Needs registrations,
authorized by Section 24(c) of the Federal Insecticide Fungicide
and Rodenticicle Act (FIFRA), as an ended, in addition to federal
registrations granted under Section 3 of the FIFRA. Future
products that differ appreciably from those described in this
Standard may require an amendment to this Standard to reflect
the difference. No new uses for disulfoton will be considered
until the human and environmental concerns raised in this
Standard are satisfactorily resolved.
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B. Chemical Description and Use Profile
Disulfoton is the common name for 0, 0—diethyl S— [ 2—(ethylthio)
ethyl] phosphorodithioate. Trade names and other names include
ethylthiodemeton, Disyston, dithiodemeton, dithiosystox, and
thiodemeton. The chemical is manufactured in the U. S. by
Mobay Chemical Corp. The empirical formula is C8H 1 9O2PS3 and
the molecular weight is 274.4. The structural formula is as
follows:
S
It
(C 2 H SO)2 — PSCH 2 CH 2 SC2H S
The 95% technical material also serves as a manufacturing—use
product under the trade name Di—Syston.
Technical disulfoton is a pale yellow liquid which
hydrolyzes under alkaline conditions, with a boiling point of
62°C at 0.01 mm/Hg. It is soluble in most organic solvents
and is soluble in water at 25 parts per million (ppm) at 20°C.
Other physical and chemical properties are vapor pressure
1.8 X l0 millibars at 20°C, and specific gravity 1.144 at
20°C/4°C. Existing data gaps relating to product chemistry
are identified in Table A and Table B.
There are five manufacturing—use products, 70 federally
registered Section 3 end—use products, 41 24(c) Special Local
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Need registrations, and 34 intrastate products containing
disulfoton as the sole active ingredient. There are also a
number of products containing disulfoton in combination with
other active ingredients. These multiple active ingredient
products include one multiple active ingredient manufacturing—
use product containing disulfoton, 29 federally registered
Section 3 end—use products, four 24(c) Special Local Need
registrations, and 11 intrastate products. The formulation
types of the above products include granulars, pelleted/tableted,
emulsifiable concentrates, and ready—to—use liquids.
Disulfoton is formulated in various percentages in
combination with benefin, chlorobenzilate, demeton, diazinon,
dicofol, ethoprop, fensulfothion, PCNB, etridiazole, trifluralin,
and vernolate.
Disulfoton, a plant systemic organophosphate chemical,
is principally used as an insecticide/acaricide for the
agricultural crops cotton, sorghum, and wheat. Additional
registered uses include the agricultural crops alfalfa, corn,
peanuts, soybeans, tobacco, pecans, various seed crops,
certain fruits and vegetables, ornamentals and nursery stock,
forest uses, greenhouse uses, and potted house plants.
Most granular disulfoton products are applied as pre—plant
or at—planting soil treatments, although emulsifiable concentrates
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and ready—to—use liquids can be applied either aerially or by
ground equipment. Certain formulations containing 10% or
greater concentrations of disulfoton are already classified
for Restricted Use (44 CFR 45131 Aug., 1, 1979) based on
dermal and/or inhalation toxicity.
C. Regulatory Position and Rationale
Based on a review and evaluation of all available data and
other relevant information on disulfoton, the Agency has made
the following determinations:
1. An interim farm worker reentry interval of 24 hours
is necessary for disulfoton under this Standard
pending receipt and evaluation of reentry studies
noted in Table A.
Rationale: The Agency is concerned about possible
dermal and inhalation exposure to farm workers
because of disulfoton’s high acute toxicity. In
order to assess this potential risk, reentry studies
(dermal exposure, inhalation exposure, foliar dissi-
pation and soil dissipation studies) and toxicity
(dermal absorption) data are required to be submitted.
In the absence of such data interim reentry intervals
will be utilized to minimize exposure to workers
entering treated fields.
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2. Product integrity studies on typical end—use disulfoton
granular formulations are being required to assess
hazards from inhalation and dermal exposure to workers
and handlers from granular formulations of disulfoton.
Rationale: Based on present use patterns and application
practices there would appear to be little likelihood of
exposure to workers resulting from the handling and
use of the disulfoton granular formulations. However,
should the granules fracture during shipping and handling,
an inhalation and dermal exposure hazard to handlers and
other workers subject to prolonged exposure may occur.
Therefore, product integrity studies are being required
to assess this possibility. Depending on results of
these studies, additional precautionary labeling and!
or other protective measures, as appropriate, will be
implemented. In addition, a subchronic inhalation exposure
study (90—day rat) and a subchronic dermal study (21—day)
may be required.
3. Disulfoton and its degradation products have potential
to leach through soil and contaminate ground water;
however the available data is insufficient to character-
ize this potential. Additional studies are being
requested. These studies include hydrolysis, metabolism
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and mobility studies. Once these additional studies
are submitted and reviewed an environmental fate
assessment on disulfoton and its metabolites and
their potential for ground water contamination can
be made.
Rationale : Preliminary information indicates that
disulfoton has a low to intermediate mobility in soils.
The mobility of its inetabolites are somewhat greater.
Because disulfoton is mainly applied by soil incor-
poration, the mobility potential is further enhanced.
The half—life and leaching potential of disulfoton
and its degradates are unknown; however, it is believed
that the degradates may persist in the soils for a
relatively long period of time.
4. The “restricted use” classification for all disulfoton
emulsifiable concentrates 65%, 21% (w/ FensulfothiOrl
43% and greater) or 32% (w/ fensulfothiOn 32% and
greater) and greater, and ready—to—use liquids 95%
and greater, and granular formulatiOns 10% and
greater (for greenhouse use) will continue . All
remaining end—use product formulations greater than
2% are hereby classified for “restricted use” on an
interim basis by this Standard, pending receipt and
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evaluation of additional data specified in Table C.
All end—use product formulations 2% and less are
not now being classified “restricted use” pending
receipt of toxicity data specified in Table C.
Rationale: The emulsifiable concentrates and ready—
to—use liquids, and granular formulations 10% and
greater (greenhouse use) were previously restricted
by regulation on August 1, 1979 (40 CFR 162.31).
Classification for the EC and liquids was based
upon acute dermal and acute inhalation toxicity, and
for the granulars for greenhouse use was based on
acute inhalation toxicity.
Though granular formulations containing greater than 2%
disulfoton were previously proposed for restricted use
on August 1, 1979 (44 FR 54219), the Agency never
promulgated a final rule classifying these formulations.
All product formulations greater than 2% are being
restricted through this Standard.
All product formulations greater than 2% released for
shipment after September 1, 1985 must be labeled for
restricted use. All such products which are in the
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channels of trade after September 1, 1986 must be
labeled for restricted use.
The September 1, 1985 date for products released for
shipment provides time for States to certify applicators
and also assures that most products used in the 1986
growing season will be classified for restricted use.
Requiring all products still in the channels of
trade after September 1, 1986 to be so restricted
will prevent stockpiling by dealers and distributors
and assure that all products greater than 2% available
for the 1986 growing season are restricted.
The decision to classify some disuifotOn registrations
as restricted use products was based on criteria set
out in §162.11(c). The principal human effects
triggers for chemicals used in non—domestic settings
are the Toxicity Category I criteria, i.e., acute
dermal LDSO — 200 mg/kg; acute inhalation LC5O — 0.2
mg/i; acute oral LD5O — 50 mg/kg. The principal
human effects triggers for pesticides used in domestic
settings are the Toxicity II criteria. Current
disulfoton end use product labels carry Toxicity
Category I, II, III designations. Based on extrapolation
of available acute oral toxicity data in our files
non—domestic use products containing 3.38% or more
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disulfoton would fall in Toxicity Category I and
domestic use products greater than O.3%* in Toxicity
Category II and thus would be candidates for restricted
use classification. The acute toxicity data base
for end—use products containing disulfoton is not
adequate for the Agency to make a final determination
which formulations warrant the restricted—use classi-
fication. Therefore the Agency will require products
greater than 2% disulfoton to be classified for re-
stricted use until appropriate toxicity studies and
other information is received. When the acute toxicity
data base is complete, the Agency will review its decision
regarding the classification of registered products
containing more than 2% disulfoton. (Refer to Data
Table C).
The majority of current disulfoton products are
registered for use on agricultural crops, commercially
grown ornamentals and limited forestry uses. However,
there are a number of products formulated at 2% and
less for use primarily by the homeowner for vegetables,
flowers and potted houseplants, which remain unclassified.
*Assumptions: A 10 kg female consumes lOg of granular
material containing .03g of chemical (96% pure) and
complete rapid absorption takes place. Calculated
from 3.38% disulfoton.
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The acute toxicology data base for disulfoton end
use products is severely lacking.
The Agency has decided not to classify product
formulations containing 2% or less as restricted
use pending receipt and evaluation of appropriate
toxicity data required under this Standard (refer
to Data Table C). After receipt of this data the
Agency will consider the acute toxicity categories
for those products 2% or less and current label
language to determine if these products warrant
restricted use classification.
5. The Attwater’s greater prairie chicken, Aleutian
Canada Goose, the Everglades kite, Slackwater darter,
woundfin, 11 freshwater mussels, longhorn beetle, delta
green ground beetle, and Kern primrose sphinx moth, all
endangered species, may be at risk from the use
of disulfoton. The Agency has decided to adopt a
generic (cluster) approach for addressing endangered
species concerns associated with the uses of pesticides.
This cluster labeling should be complete by the
1986 growing season; if it is not, the need for
interim labeling statements will be reconsidered.
No labeling statements are currently proposed pertaining
to endangered species.
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Rationale: The Office of Endangered Species of the
United States Department of Interior, representatives
of agricultural interest groups and the Agency
believe the conventional labeling approach is inadequate
to properly inform the users on how to protect the
endangered species and at the same time use the
product to the greatest benefit.
It is presently anticipated that appropriate labeling
will be developed in time for the 1986 growing
season for these five crops. If not, this Standard
may be amended to impose interim labeling to protect
endangered species which may be affected by use of
disul foton.
6. No new uses of disulfoton will be allowed until
the the human dietary concerns have been resolved
through receipt and analysis of pending toxicology
and residue data.
Rationale: The Agency is unable to complete a tolerance
reassessment because of certain residue chemistry
and toxicology data gaps, therefore the Agency
cannot propose a change in present tolerances.
However the provisional acceptable daily intake
(PADI) has been exceeded, and because of this, no
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new uses for disulfoton will be allowed until the
human and environmental concerns raised in this
standard have been addressed. (Refer to Section G:
Tolerance Reassessment.)
7. The available field and laboratory studies and
reports of livestock kills corroborate the Agency’s
findings that disulfoton is very highly toxic to
fish and highly toxic to birds and rnamn als. The
hazard to terrestrial species can result directly
from ingestion of granules or indirectly by consumption
of invertebrates, vegetation, or water containing
disulfoton residues. Available data are not sufficient
to assess the significance of this hazard, i.e., to
determine if significant population reduction will
occur. Full field studies including population
monitoring are required. Depending on the results
of the environmental fate studies, an avian repro-
duction study may be required as well. Depending
on the results of the requested metabolism data
and the likelihood that the metabolites may be more
toxic than disulfoton itself acute toxicity studies
of metabolites may be required for mammalian and
avian species.
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For the hazard to fish, additional data are needed
before the Agency can complete a full assessment
of this hazard potential. Depending on the results
of the environmental fate studies full field studies
with pbpulation monitoring may be required. A fish
early life—cycle study and an aquatic organism
accumulation study may also be required depending
on the result of lower tier studies and environmental
fate data. After the Agency has evaluated these
data, it will determine whether EPA should initiate
a public interim review process by placing the
chemical in Special Review.
Rationale: A total risk assessment cannot be made
until gaps in the data base for aquatic and terrestrial
species and environmental fate are filled. Because
exposure data were insufficient to judge the level
of concern for disulfoton, the most appropriate
regulatory action is to move expeditiously in filling
the data gaps. If, after review of these data,
regulation of the chemical through the normal regis-
tration process is found to be appropriate, the Agency
will update its regulatory position and rationale to
reflect this conclusion and the reasoning behind it.
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8. Manufacturing—uSe and end—use products containing
disulfoton must bear revised environmental hazard
statements reflecting the pesticide’s toxicity to
fish and wildlife (refer to Section F. “Required
Labeling).
Rationale: Based upon studies available to assess
hazards to wildlife and aquatic organisms, disulfoton
is characterized as very highly toxic to mammals
and aquatic organisms (especially freshwater fish),
moderately toxic to highly toxic to birds and
moderately toxic to honey bees. updated label
precautions required under this Standard should
reduce the hazard to fish and other wildlife.
9. The tank mixing of disulfoton with Phosalone for
use on pecans and potatoes is prohibited. (Refer
to Section F, Required Labeling, for the exact
labeling statement.)
Rationale: Laboratory potentiation studies with
disulfoton and other organophosphate chemicals
indicates that the acute toxicity of disulfoton,
when mixed with Phosalone and fed to laboratory
animals, was enhanced over sixteen times. None
of the other tested chemicals potentiated disulfoton’S
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toxicity. The Agency concludes that this potentiation
may occur due to a peculiarity of the Phosalone
molecule, but the exact mechanism is unknown. Since the
Agency has identified only two uses, (pecans and potatoes)
where these two chemicals could be used together, a
label prohibition against tank mixing Phosalone and
disulfoton for these uses is warranted.
10. Data to evaluate spray drift potential are needed.
Those data being required include droplet size
spectrum studies and field evaluation of pesticide
drift (refer to Table A).
Rationale: The Agency is concerned about potential
hazards to non—target organisms (domestic animals
and humans) from drift after spray applications of
disulfoton. This concern is due to the very high
toxicity of the chemical to all mammalian species
by all routes of exposure (Toxicity Category I).
Pesticide Incident Monitoring System (PIMS) incidents
lend some support to this concern. Of ten incidents
involving domestic animal mortality or morbidity at
least three involved deaths to large numbers of
horses consuming disulfoton contaminated hay. Of
these three incidents one was definitely attributed
to spray drift contaminating grazing areas.
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11. By this Standard, the Agency is requiring the
submission of applications for full registration of
all intrastate products containing disulfoton by
December 31, 1985 . An “intrastate product is one
registered by a State before August 3, 1975,
and for which a Notice of Application was filed
with the Agency before October 4, 1975. Such
products were assigned Accession Numbers by EPA;
the latter part of this number, the product number,
is greater than or equal to 3000, e.g., 1256—5779.
If you have such a product containing disulfoton,
you must submit an application for registration
including the following information:
A. An Application for New Registration (EPA
Form 8570—1);
B. A complete and accurate Confidential
Statement of Formula (EPA Form 8570—4);
C. A copy of draft labeling complying with the
requirements of 40 CFR 162.10 and this
Standard;
D. Data required by 40 CFR Part 158 for your
product; and
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E. Information to show your compliance
with the requirements of FIFRA sec. 3(c)(l)(D)
pertaining to compensation for use of data
submitted by another person. (Refer to
PR Notice 84—4 for the latest information.)
Any distribution or sale of an intrastate (not federally
registered) product containing disulfoton after the
deadline will be considered to be in violation of
FIFRA sec. 12(a)(l)(A). For those intrastate
products that are issued a Federal registration,
the labeling timeframes set out in section 6 of
this Standard (Required Labeling) apply to the
product. If you do not wish to pursue Federal
registration of your intrastate product, you should
request withdrawal of your Notice of Application.
If you request withdrawal of your Notice, or if you
fail to respond to this notification, you may not
distribute or sell the intrastate product after
December 31, 1985 . Products already in channels of
trade as of that date may continue to be distributed
and sold by dealers and retailers until June 30, 1986
Any product found in channels of trade after
June 30, 1986 will be considered to be in
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violation of FIFRA sec. 12(a)(l)(A).
Rationale: At the time that the Notice of Application
was filed with the Agency, the producer of the intra-
state product agreed to submit an application for
full Federal registration when directed to do so by
the Agency. It is EPA policy that the Agency will
require the producer of an intrastate product to
submit an application for federal registration if
the intrastate product contains the same active
ingredient and is intended for the same or a
substantially similar end use as federally registered
products which are subject to:
A. A notice of Rebuttable Presumption Against
Registration (RPAR) or Special Review;
B. A notice under FIFRA sec. 3(c)(2)(B)
requiring the submission of data in support
of federal registration;
C. A regulation or notice classifying the
product for restricted use under FIFRA
sec. 3(d)(l)(C); or
D. A notice requiring the federal registrant
to submit an application for reregistration
of his product.
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Under FIFRA sec. 12(a)(1)(A), it is unlawful for a
person in any State to distribute or sell any pesti-
cide which is not registered under section 3 [ except
as provided by section 6(a)(lfl.
12. Pesticide products containing disulfoton as an
active ingredient may be registered for sale, distri-
bution, reformulation, and use, subject to the
terms and conditions specified in this Standard.
Affected registrants must provide (or agree to provide
additional in the case of scientific studies) data,
labeling and comply with the data compensation
provisions of FIFRA sec. 3(c)(1)D. Applicants for
new registrations of products containing disulfoton
must also comply with these same requirements.
Rationale: Under FIFRA, the Agency cannot cancel or
withhold registration simply because data are missing
or inadequate (see sections 3(c)(2)(B) and 3(c)(7)
of the FIFRA). Rather, issuance of this Standard
provides a mechanism for identifying data needs.
These data will be reviewed and evaluated when they
are received and the Agency will determine at that
time if they will affect the registration(s) of
disulfoton.
22
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D. Criteria for Registration under the Standard
To be acceptable for registration under this standard,
products must contain disulfoton as the sole active
ingredient, bear required labeling, and conform to the
product composition, acute toxicity limits, and use
pattern requirements listed in Section E of this document.
The applicant for registration or reregistration of
products subject to this Standard must comply with all
terms and conditions described in it, including submission
of an up—to—date Confidential Statement of Formula,
submission of revised labeling, commitment to fill data
gaps on the schedule specified by the Agency
and, when applicable, offer to pay compensation as
required by 3(c)(l)(D) and 3(c)(2)(D) of the Federal
Insecticide, Fungicide and Rodenticide Act (FIFRA), as
amended, 7 U.S.C. 136(c)(l)(D) and 136(c)(2)(D).
Registration applicants must contact the Agency for
specific instructions, including updated information on
data requirements and companies whose data must be
cited and to whom compensation must be offered.
E. Acceptable Ranges and Limits
1. product Composition Standard
To be covered under this Standard, manufacturing—use
products must contain disulfoton as the sole active
23
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ingredient. Each MP formulation proposed for
registration must be fully described with an
appropriate certification of limits, stating maximum
and minimum amounts of the active ingredient and any
intentionally—added inert ingredients which may be
present in products.
2. Acute Toxicity Limits
The Agency will consider registration of technical
grade and manufacturing—use products containing
disulfoton, provided that the product labeling
bears appropriate precautionary statements for the
acute toxicity category in which each product is
placed.
3. Use Patterns
To be registered under this Standard, manufacturing—
use products containing disulfoton may be labeled
for formulation into end—use products only for the
commodities listed below. The attached “EPA Index
to Pesticide Chemicals” entry lists all registered
uses, as well as approved maximum application rates
and frequencies.
—Terrestrial, non—domestic, food uses on:
alfalfa, barley, beans (dry, snap, lima),
24
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bermudagrass [ seed crop (24(C)] blackeyed
peas (seed crop), broccoli, Brussels sprouts,
cabbage, carrots (seed crop), cauliflower,
clover, coffee, corn, cotton, garlic (seed
crop), hops, lettuce, oats, onion (seed crop),
peanuts, peas, pecans, peppers [ 24(C)] pineapple,
potato, radish (seed crop), rice, sorghum,
soybeans, spinach, strawberries (propagating
plants), sugar beets, sugarcane, tomato,
turnips (seed crop), and wheat.
—Terrestrial, non—domestic, non—food uses on:
non—bearing fruit trees (apple, apricot, cherry,
crabapple, peach, pear, plum and prune), raspberry
(nursery stock), tobacco, ornarnentals (herbaceous
plants, woody shrubs, trees) and forest plantings.
—Domestic outdoor use on: potted plants,
ornamentals (herbaceous plants, flowers,
woody shrubs, trees).
—Domestic indoor use on: potted plants,
ornamentals (specified above).
—Greenhouse non—food use on: ornamentals
(specified above).
25
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F. Required Labeling
All manufacturing—use and end—use disulfoton products
must bear appropriate labeling as specified in 40 CFR
162.10. This guidance document contains information on
label requirements. All labeling changes must appear
on all products released for shipment after
September 1, 1985 . All labeling changes must appear on
all products in channels of trade as of September 1, 1986 .
In addition to the above, the following information must
appear on the labeling:”
1. Ingredient Statement
The ingredient statement for MPs must list the active
ingredient as:
0,0—Diethyl S— [ 2—(ethylthio)ethyl] phosphorodithioate....____
2. Use Pattern Statements
All manufacturing—use disulfoton products must state
that they are intended for formulation into end—use
products for the aforementioned use patterns.
Labeling must specify sites, which are listed in
Use Patterns , Section E.3. A limiting factor will
be data that supports these use patterns. No use
may be included on the label where the registrant
fails to agree to comply with the data requirements
in either Table A or Table B for that use pattern.
26
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3. Precautionary Stat nents
Stat nents for Manufacturing—Use Products
a. Labels for manufacturing—use disulfoton products
must bear statements reflecting the canpound’s
acute h .unan toxicity. Disulfoton is in ltxicity
Category I by all routes of exposure; the required
precautionary stat nts associated with this
category are specified in 40 CFR 162.10.
b. The following revised environrrental hazard
stat nent must appear on all MP labels:
“This pesticide is toxic to fish and
wildlife. IX not discharge effluent con-
taining this active ingredient into lakes,
streams, ponds, estuaries, oceans or public
waters unless this product is specifically
identified and addressed in an NPEES permit.
1X not discharge effluent containing this
product to sewer syst ns without previously
notifying the sewage treatnEnt plant
authority. For guidance contact your
State Water Board or Regional Office of
the EPA.’
27
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Statements for End—Use Products
a. The following “Restricted Use” statement must
appear on the label of disulfoton products
classified for restricted use:
“Restricted Use Pesticide —
acute human oral, dermal, and inhalation toxicity”
“For retail sale to and use only by certified
applicators or persons under their direct
supervision and only for those uses covered by
the certified applicator’s certification.”
b. In the use directions for pecans and potatoes
add the following prohibition:
“Do not tank mix this product with Phosalone.”
C. Add the following worker reentry statement to
the labeling of products with directions for use
on crops.
“Do not allow reentry into treated fields
within 24 hours of application unless
appropriate protective clothing is worn.”
d. Revise the existing environmental hazards
statements to read:
28
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“This pesticide is toxic to fish and wildlife.
Do not apply directly to water or wetlands.
Drift and runoff from treated areas may be
hazardous to fish in neighboring areas. Do
not contaminate water by cleaning of equipment
or disposal of wastes. Cover or incorporate
spills.
This pesticide is toxic to bees exposed to
direct application. Applications should be
timed to coincide with periods of minimum
bee activity, usually between late evening
and early morning.”
e. Pursuant to PR Notice 83—2, the general worker
protection statements specified in that notice
must appear on the labeling of outdoor
agricultural use products which are applied to
crops whose culture requires hand labor. Such
products released for shipment after
December 31, 1984, must meet the requirements
of this PR Notice.
f. In the absence of crop rotation data, the crop
rotation restriction below must be placed on all
products which may be used in a situation where
29
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rotation with crops used for food or feed that
are not registered with disulfoton may occur:
“Do not plant any food or feed crop in rotation after
a field treatment with disulfoton unless it is a
registered use for disulfoton”
C. Tolerance Reassessment
U. S. tolerances ranging from 0.1 to 12.00 parts per
million (ppm) have been established for the combined
residues of disulfoton and its cholinesterase—inhibiting
metaboljtes, calculated as demeton* on a variety of raw
agricultural commodities (RAC) (40 CFR 180.183) and on
the processed feed commodities dried sugarbeet pulp and
pineapples bran at 5 ppm (21 CFR 561.160). A summary
of the RAC tolerances are presented in Table II located
at the end of this section and include Canadian and Codex
Maximum Residue Limits. There are no Mexican tolerances
for the commodities listed in Table II.
The metabolism of disulfoton in plants [ 0,0—diethyl S— [ 2—
(ethylthio)ethyl]phosphorodjthjoate (I)] is partially
understood. Disulfoton is readily absorbed and translocated
by plants. Table I (at the end of this section) depicts
the molecular structures of disulfoton and its known metabolites.
Identified metabolites included 0,0—diethyl S— [ 2—(ethylsulfinyl)
*Demeton (0,0—diethyl 0— [ 2—(ethylthio)ethyl] phosphorothioate
is a systemic organophosphate insecticide
30
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ethyl]phosphorodjthjoate (II), 0,0—diethyl S— [ 2—(ethylsulfonyl)
ethyl]phosphorodithjoate (III), 0,0—diethyl S— [ 2—(ethylsul—
finyl)ethyl]phosphorothjoate CV), 0,0—diethyl S— [ 2—
(ethylsulfony])ethyljphosphorothjoate (VI), 0,0—diethyl
phosphoric acid (VII), 0,0—diethyl phosphorothjoate (VIII),
and phosphoric acid (IX). Although not identified in the
available metabolism studies, 0,0—diethyl S— [ 2—(ethylthjo)
ethyl)phosphorothioate (IV) is a metabolite expected to
occur as an intermediate through oxidation; this compound
is identical to the demeton thiol isomer and is likely a
transient disulfoton intermediary metabolite.
Data delineating the quantification of all oxidative
metabolites is also required for tolerance reassessment.
The Agency is requiring studies of metabolites utilizing
ruminants and poultry to determine distribution and
characterization of residues in tissues, milk, and
eggs as well as an animal metabolism Study (preferably
in the rat) to delineate the pharmokinetic and pharrna—
codynamic aspects of disulfoton, particularly the rate
of conversion of oxidation metaboljtes from one to
another.
Tolerances are currently expressed in terms of the
combined residues of disulfoton and its cholinesterase—
31
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inhibiting nietabolites calculated as demeton, which
consists of a mixture of the following two isomers:
0,0—diethyl O— [ 2—(ethylthio)ethyl]phosphorothioate
and 0,0—diethyl S— [ 2—(ethylthio)ethyl]phosphorothioate.
The Agency has determined that it is inappropriate to
calculate residues as demeton. Instead, calculation of
disulfoton residues as disulfoton sulfone (III) would
be more appropriate because: Ci) this compound has
the greatest molecular weight of disulfoton and its
metabolites (18.6% higher than demeton); (ii) it
appears to be a major disulfoton residue in or on plants
as a result of treatment whereas demeton thiono isomer
is not expected to occur as a disulfoton metabolite;
(iii) all analytical methods available involve oxidation
to disulfoton sulfone and/or disulfoton 0—analog sulfone
and, therefore, even if present, demeton would be oxidized
to the corresponding sulfone; and (iv) the Gas Chromatographic
(GC) detector response is greater to disulfoton sulfone
than to disulfoton 0—analog sulfone.
Disulfoton per se (I) is detectable only very soon after
treatment of plants. The 0—analog (IV) has not been detected
in plants, presumably due to rapid oxidation of the ethylthio
sulfur atom of disulfoton or the 0—analog, if formed.
Disulfoton sulfone (III) and the 0—analog sulfone (VI) are
32
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expected to be the major residues at the time of harvest of
treated plants whereas disulfoton sulfoxide (II) and 0—analog
sulfoxide (V) will generally be present in lesser quantities.
Therefore the current tolerances in 40 CFR 180.183 and
21 CFR must be redefined in terms of disulfoton sulfone.
Although plant residues were found to consist almost
entirely of oxidation products, the nature and magnitude
of the anticholinesterase activity of these individual
metabolites were not originally considered in the
establishment of existing tolerances. Available studies
show certain oxidation products to be more potent cholines—
terase inhibitors than the parent compound, and, considering
this fact, the actual toxic burden in the diet may be
greater than current calculations indicate.
The acceptable daily intake (ADI) for cholinesterase
inhibition in man is usually determined on the basis
of a no—observed—effect—level (NOEL) from a rat chronic
feeding study using a normal 10 fold safety factor.
However, since the rat chronic feeding study was unaccept-
able for setting the ADI, a provisional acceptable daily
intake (PADI) for cholinesterase inhibition was
established on the basis of a NOEL from a dog chronic
feeding study using the customary 10 fold safety factor.
33
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A PADI for disulfoton of 0.0025 mg/kg/day was established
using a NOEL of 1.0 ppm (0.025 mg/kg) and the maximum
permissible intake (MPI) for a 60 kg person is 0.1500
mg/day.
Toxicological studies are needed to establish acceptable
metabolites. The use of a PADI of 0.0025 mg/kg/day
replaces the previous ADI of 0.005 mg/kg/day and may
accomodate the uncertainty surrounding greater toxicity
and serve to alleviate dietary concerns in the interim
between issuance of this Standard and the time the
Agency receives and analyzes the metabolite data.
The theoretical maximum residue contribution (TMRC) to
the human diet from existing tolerances is 0.2544 mg/day
(in 1.5 kg of human diet) and represents 169.59% of the
PADI. However, a reassessment of the current tolerances
based on actual constituents of the plant residues is
necessary and additional residue data are needed to
determine the nature and magnitude of human dietary
exposure to disulfoton’s metabolites.
Although the Agency is concerned about exceeding the
PADI no regulatory action is warranted now pending
receipt of metabolite toxicity and residue chemistry
34
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data with which to evaluate the magnitude of human
dietary exposure to disulfoton and its metabolites.
The Agency believes, for several reasons, that the
public will be in no inunediate danger while awaiting
exposure assessment data.
The TMRC assumes that 100 percent of the crop for which
a tolerance is established is treated with disulfoton.
Disulfoton’s major uses are cotton, sorghum, and wheat,
and the estimated percentage of disulfoton’s use on
these crops is low. When adjustments are made for the
estimated percentage of crops treated with disulfoton,
The Agency assumes the ratio between residue contribution
and the PADI is actually much lower than 169%.
The Agency recognizes that the statistical significance
of the Food and Drug Administration’s market basket
survey is limited, but results from this monitoring can
function as an indicator of immediate dietary exposure
risks. Monitoring activity for the past several years
shows that although present, disulfoton residues are
consistently below established tolerances, which further
alleviates the Agency’s immediate concern over disulfoton’s
use while collecting data for a tolerance reassessment.
The Agency is requesting data pertinent to the
35
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reassessment of current tolerances on an accelerated
basis as indicated in Table A.
Additional residue data required to support existing
tolerances for disulfoton residues in or on certain
commodities are listed in Table A. The Agency is also
requesting that certain additional tolerances be
proposed for certain agricultural commodities and
feed/food items. No new crop groupings can be
established at this time because of extensive residue
chemistry data gaps. Compatibility between Codex MRL’s
and U.S tolerances will be assessed when data specified
in Table A have been submitted and evaluated. Because
the Agency is concerned about the magnitude of the
metabolites’ toxicity and their effect on the dietary
assessment for disulfoton, and considering the fact
that certain food processing techniques could increase
the dietary exposure through enhanced oxidation, the
Agency may request post—processing residue data be
submitted after the above—noted residue data have been
submitted and evaluated.
36
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Table 1. Disulfotori and its rnetabolites.
Code Structure Ch 1ca1
5 O,G-dlet*yl S—C2—(ethylthlo)ethyt]phosphoroditl.loate 1s 1fot n
(co)z sc izcI12sc2Hs
i i 0 O.O-dlethyl S—C2—(ethy sul finy )etflyl ]phosphorodltMo.te Dl sul toWn
(c so)zPsc as2 c 5 sulfoxide
Lu o 0,0—diethyl S42—(sthylsulfonyl )et1ly1]pI sphorod1th1oate Disulfoton
H II sulfon.
(c 2 Hso)zPscHta’42sc2u5
Iv a 0,0—diethyl S—(2—(ethyl thlo )ethyl ]pnospt rothioat* Olsul foton
ii O —ana og
(C 2 HSO) 2 PSCH2*12 5C2H5
v o 0,0—disthyl S-(2—(ethy suIfVnyL)eUIy1]pnosphorotMoate D1 u1foton
II II O- .naloç
(CZf., 0) 2 PSOi O1 2 SCZH5 sulfoxide
0 0 O.O—dletflyi S—(2.(ethyl uI fotlyl ) .thyl ]phospnorctfllo.te Dl sulfoton
II II O-.n .Iog
(c 2 H 5 o) 2 Psc,l 2 cH 2 sc 2 s-i 5 sulfone
0
v i i O,D—dlethyi p soIsoric acid Oletnyl PfloS-
II D i late
(c 2 M 5 o) 2 e 0H
VIII 0 O ,G-diethyl Dilouflorothlcate Oletilyl phos-
II pl lOrOtMObte
(c o) ps
PI sphor1c acid
37
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TABLE II
SUMMARY OF PRESENT TOLERANCES
Commodity
alfalfa (fresh)
alfalfa (hay)
asparagus
barley (fodder,green)
barley (grain)
barley (straw)
beans (dry)
beans (lima)
beans (snap)
beans (vines)
beets, sugar (roots)
beets, sugar (tops)
broccol i
brussels sprouts
cabbage
cauliflower
clover (fresh)
clover (hay)
coffee beans
corn, field (fodder)
corn, field (forage)
corn, (grain)
corn, pop
corn, pop (fodder)
corn, pop (forage)
corn, sweet (fodder)
corn, sweet (forage)
corn, sweet, grain
(kernels plus cob with
husks removed)
cottonseed
hops
lettuce
oats (fodder, green)
oats (grain)
oats (straw)
peanuts
peanuts (hay)
peanuts (hull)
peas
peas (vines)
Tolerances (ppm)
U.S.(a) Canada Codex (MRL)(b)
5.0
12.0
0.1
5.0
0.75
5.0
0.75
0.75
0.75
5.0
0.5
2.0
0.75
0.75
0.75
0.75
5.0
12.0
0.3
5.0
5.0
0.3
0.3
5.0
5.0
5.0
5.0
0.3
0.75
0.5
0.75
5.0
0.75
5.0
0.75
5.0
0.3
0.75
5.0
10.0
0.5(c)
5.0(d)
0.2(f)
0.5(c)
0.5(c)
0.5(c)
0.5
0.5(c)
0.5(c)
0.5(c)
0.5(c)
10.0
0.1
0.5(e)
0.5(e)
0.5(e)
0.5(e)
0.5(e)
0.5(e)
0.5(e)
0.5(e)
0.5
0.5
0.5
0.5
0.5
0.5
0.5
0.1
0.1
0.1
0.1
0.1
0.1
0.1
0.1
per
per
per
per
per
per
per
per
per
per
per
per
per
se
se
se
se
se
se
se
se
se
se
se
se
se
se
se
0.1 per se 0.5(e)
0.5 P! se 0.5(c)
0.2(f)
0.1(a)
0.5 per se 0.5(c)
38
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Commodity
pecans
peppers
pineapples
pineapples (forage)
potatoes
rice
rice (straw)
sorghum (fodder)
sorghum (forage)
sorghum (grain)
soybeans
soybeans (forage)
soybeans (hay)
spinach
sugarcane
tomatoes
wheat (fodder, green)
wheat (grain)
wheat (straw)
TABLE II (cont.)
SUMMARY OF PRESENT TOLERANCES
0.75
0.1
0.75
5.0
0.75
0.75
5.0
5.0
5.0
0.75
0.1
0.25
0.25
0.75
0.3
0.75
5.0
0.3
5.0
0.1
0.5(c)
0.1
0.5
0.5(h)
5.0(d)
5.0(d)
0.2(f)
0.1
(a) Disulfoton and its cholinesterase inhibitin metabolites, calculated
as demetori
(b) Additive residues of disulfoton, demetori—S, and their sulfoxides and
sulfones, expressed as disulfoton
(c) In or on vegetables
(d) In or on all green forage crops
(e) In or on maize
(f) In or on all cereal grains
(g) Kernels only
(h) In or on rice in the husk
Tolerances (ppm)
U.S.(a) Canada Codex (MRL)(b)
0.1 per . !
0.2 2
0.5 per . ! 0.5(c)
0.5 per . ! 0.5(c)
0.2(f)
Footnotes for Table II
39
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EPA Index to Pesticide Chemicals
0,0—DIETHYL S- [ 2—(ETUYLThIO)EThYLI PHOSPHORODITHIOATE
TABLE OF CONTENTS
AGRICULTURAL CROPS
Alfalfa 2
Apple (nonbearing) 3
Apricot (nonbearing) 3
Barley 4
Beans, Dry 4
Beans, Liina 4
Beans, Snap 4
Bermudagrass (seed crop) 5
Blackeyed Peas (seed crop) 5
Broccoli 5
Broccoli (transplant beds) 6
Brussels Sprouts - 6
Brussels Sprouts (transplant beds) 6
Cabbage 7
Cabbage (transplant beds) 6
Carrots (seed crop) 7
Cauliflower 8
Cauliflower (transplant beds) 6
Cherry (nonbearing) 3
Clover 8
Clover (seed crop) 8
Coffee 9
Corn 9
Cotton 10
Crabapple (nonbearing) 3
Issued: 5—11—82 111—032501—i
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EPA Index to Pesticide Chemicals
0 ,O-DIETHYL S- [ 2-( ETHYLTHIO) ETHYL] PHOSPHOROD ITHIOATE
TABLE OF CONTENTS
Garlic (seed crop) 7
Hops 12
Lettuce 13
Oats 13
Onion (seed crop) 7
Peach (nonbearing) 3
Peanuts 14
Pear (nonbearing) 3
Peas 15
Pecan 15
Peppers 16
Pineapple 16
Plum (nonbearing) 3
Potato 17
Prune (nonbearing) 3
Radish (seed crop) 7
Raspberry (nursery stock) 18
Rice 18
Sorghum 19
Soybeans 20
Soybeans (seed crop) 21
Spinach 21
Strawberries (propagating plants) 21
Sugar Beets 22
Sugarcane 22
Tobacco 23
Issued: 5—11—82 111—032501—il
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EPA Index to Pesticide Chemicals
0 ,O—DIETHYL S— [ 2—(ETHYLTHIO)ETHYL] PHOSPHDRODITHIOATE
TABLE OF CONTENTS
Tobacco (transplant beds) 23
Tomato 24
Tomato (transplant beds) 25
Turnips (seed crop) 7
Wheat 26
ORNAZIENTALS
( Ornamental Plants (herbaceous, woody shrubs, trees and vines) )
Ornamental Herbaceous Plants 27
Ornamental Trees 28
Ornamental Trees (nursery stock) 29
Ornamental Woody Shrubs 28
Ornamental Woody Shrubs (nursery stock) 29
( Ornamental Houseplants )
Ornamental Herbaceous Plants (houseplants) 30
FOREST, CHAPARRAL, NONAGRICULTURAL AND WASTELANDS
Forest Plantings 30
AERIAL, MOThPROOFING AND TANK MIX APPLICATIONS
Aerial Application 30
Issued: 5—11—82 111—032501—ui
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EPA Index to Pesticide Chemicals
c032501 0,0—DIETHYL S— [ 2-(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE*
TYPE PESTICIDE : Insecticide, Acaricide
FORMULATIONS :
Tech (95%)
Fl (2%, 2.2%, 5%, 68%)
G (0.25%, 0.28%, 0.33%, 0.4%, 0.5%, 0.625%, 0.67%, 0.75%, 0.8%, 0.99%,
1%, 1.33%, 2%, 5%, 10%, 15%)
PIT (2%)
EC (6 lb/gal, 8 lb/gal)
RTU (95%)
GENERAL WARNINGS AND LIMITATIONS : The following formulations are
RESTRICTED USE PESTICIDES:
Emulsifiable concentrates — All emulsifiable concentrates 65 percent and
greater, all emulsifiable concentrates and concentrate solutions 21 per-
cent and greater with fensulfothion 43 percent and greater, all emulsifi-
able concentrates 32 percent and greater in combination with 32 percent
fensulfothion and greater.
Liquid—ready to use — 95 percent and greater
Granular — 2 percent and greater (for use in greenhouses)
The use of granular formulations greater than 2 percent are limited to
commercial applicators.
Do not apply with a knapsack or other equipment that is placed on the
user’s body.
Disulfoton is toxic to fish and wildlife. Do not apply directly to water
or wetlands. Drift and runoff from treated areas may be hazardous to fish
in neighboring areas. Do not contaminate water by cleaning of equipment
or disposal of wastes. Cover or incorporate spills.
Bee Caution :
Disulfoton is toxic to bees exposed to direct application. Applications
should be timed to coincide with periods of minimum bee activity, usually
between late evening and early morning.
Agricultural Crop Tolerances :
Peppers — 0.1 ppm
Definition of Terms :
Claims for pest control limited to suppression of populations are indicat-
ed by parenthesized pest name.
*Djsul foton
Di—Syston
Issued: 5—11—82 1 1 1—032501—i
Provisional Update: 12—05—84
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EPA Index to Pesticide Chemicals
0, 0-DIETHYL s- [ 2-(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
AGRICULTURAL CROPS
General Warnings and Limitations : On row crops where row spacing is
extremely narrow, do not place treated zones (band or furrow) closer
together than 6 inches.
Do not reenter treated fields within 24 hours of application. If reentry
prior to 24 hours is required, appropriate protective clothing must be
worn.
Do not plant any crop used for food or feed in disulfoton treated soils
other than those with registered disulfoton uses.
Plant Response Precaution : When used on beans, cotton, lett:uce, sugar
beets, or tomatoes at the maximum recommended rates under adverse condi-
tions such as extremely cool or wet or extremely dry weather disulfotort
may cause some delay in emergence, stunting of seedlings, or reduction of
stand. Damage may be more pronounced in light, sandy soils.
Emulsifiable concentrate formulations : Apply in a water emulsion or with
liquid fertilizer. When mixing with certain high phosphorous fertilizers
an anionic water soluble adjuvant may be needed. Unless otherwise speci-
fied, apply per acre races in a minimum of 1 gallon of water per acre by
aircraft or ground equipment. Unless otherwise specified, per 1,000 foot
row dosages are applied as a soil injection. Low volume soil injection
equipment may be used when applying more than 1 quart (6 or 8 pounds per
gallon) liquid per acre.
Granular formulations : Broadcast foliar applications may be applied by
aircraft.
Resistance to disulfoton : Due to greenbug resistance in certain areas
within the high plains of TX, eastern NM, the OK panhandle, eastern CO,
western KS, and SD, disulfoton used alone may not provide satisfactory
control. Consult state cooperative extension service for additional
information.
/23001AA Alfalfa 5 ppm (fresh alfalfa)
12 ppm (alfalfa hay)
No preharvest or pregrazing interval
through 1 pound per acre for broad-
cast application.
Allow a minimum of 28 days between
applications.
IRACAAA Aphids 1 lb/A Broadcast application at planting,
ILAAABA Mites (0.25—15% G) prior to growth in the spring, or
during the growing season.
1 lb/A Broadcast application. Apply in
(6 lb/gal EC) early spring prior to growth or to
the stubble after the alfalfa has
been cut and removed from the field.
Do not apply to alfalfa foliage.
Issued: 5—11—82 111—032501—2
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EPA Index to Pesticide Chemicals
0 ,0—DIETHYL. S— [ 2—(ETUYLTHI0)ET1IYLJ PHOSPHORODITRIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulationl .s )
/2300 1BA Alfalfa (seed crop) 12 ppm (alfalfa hay)
Chaff and hulls from treated seed
crop may be used for feed, however,
do not use green chop for feed or
forage.
14 day preharvest interval through
1 pound per acre for foliar applica-
tion to seed crop.
Do not make more than 4 applications
during the growing season.
£RACAIA Pea aphid 0.5—1 lb/A Foliar application to seed crop.
(6—8 lb/gal
EC)
/O4001DA Apple (nonbearing) N.F.
IO500IDA Apricot (nonbearing) Do not apply to trees that will bear
/05002DA Cherry (nonbearing) fruit during current crop year.
/04002DA Crabapple (nonbearing)
/05004DA Peach (nonbearing)
/04003DA Pear (nonbearing)
/05005DA Plum (nonbearing)
/05006DA Prune (nonbearing)
IRACAAA Aphids 0.375—4.05 Soil application to nonbearing
IQAXAAA Lace bug oz/tree stock. Apply uniformly from trunk
IRAFAAA Leafhoppers or to drip line on all sides. Incor—
ILAAABA Mites 0.375—0.4 oz/ porate into soil and water thorough—
IMOAAAA Thrips in. of trunk iy. Apply the higher per tree dos—
£RABAA.A Whiteflies diameter age for heavy organic or muck soils.
(5—15% G)
Soil application to nonbearing
stock at transplanting. Apply
equivalent amount to planting hole.
Apricot See Apple (noribearing) cluster.
Issued: 5—11—82 111—032501—3
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EPA Index to Pesticide Chemicals
0, 0—DIETHYL S—(2—(EThYLTHIO)ETHYL] PHOSPHORODITHIOATE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
0.75 ppm (grain)
5 ppm (green fodder and straw)
60 day preharvest interval (grain)
through 1 pound per acre for foliar
application.
30 day pregrazing or preharvest
interval (forage, fodder) through I
pound per acre for foliar applica—
t ion.
Do not
during
method
make more than 2 applications
crop season regardless of
of application.
Foliar application. Apply lover
rate on plants up to tillering
(stooling) and higher rates on
plants after tillering. For appli-
cation in liquid fertilizer, apply
as a topdress by ground equipment.
Observe resistance statement.
Refer to Oats for additional information.
0.75 ppm (beans: dry, lime, snap)
5 ppm (bean vines)
60 day preharvest interval through
1.9 ounces per 1,000 feet of row for
soil application. Do not make more
than 1 application during the grow-
ing season.
For extremely narrow row spacing,
do not apply more than 2 pounds per
acre. Observe plant response pre-
caution.
IRACAAA
tRAP A.AA
INAPAFC
IIAAABA
IMOAAAA
Aphids
Leafhoppers
Mexican bean beetle
(larvae)
Mites
Thrips
0.9—1.9 oz/
1,000 ft row
(0.4—15% G)
(6—8 lb/gal
EC)
or
0.01—0.018 oz
/10 ft row
(1—2% C)
/28063AA Barley
IP..ACDNA
Greenbug 0.5—1 lb/A
(6—8 lb/gal
EC)
Beans, Dry
Beans, Lime
Beans, Snap
/1500 IAA
/ 15002AA
/I50 03AA
Soil application at planting
(double band). Apply a band on
each side of the furrow. Do not
apply directly on the seed.
Issued: 5—11—82
111—032501—4
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EPA Index to Pesticide Chemicals
0, 0-DIETHYL S- [ 2-(ETHYLTHIO)ETHYU PHOSPHORODITHIOATE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
Beans, Dry cluster (continued)
.1 1500 IAA
IRACAAA
RAFAAA
INAPAFC
ILAAABA
IMOAAAA
(Beans, Dry)
Aphids
Leafhoppers
Mexican bean beetle
(larvae)
Mites
Thrips
0.9—1.9 oz/
1,000 ft row
(0.4—15% G)
(6—8 lb/gal
EC)
or
0.01—0.018 oz
/10 ft row
(1—2% G)
/15008BA Blackeyed Peas (seed crop)
Crowder Peas (seed crop)
Southern Peas (seed crop)
or
0.01 oz/l0
row
(1—2% C)
This use only occurs on 24(c) Spe-
cial Local Need labeling and has not
been included in this entry. Refer
to appropriate labeling for use in—
format ion.
N.F.
Soil application at planting
(double band). Apply band on each
side of seed furrow. Do not apply
directly on the seed.
OR
Postemergent soil application
(band). Apply as a sidedress after
plants are established.
0.75 ppm
14 day preharvest interval through
1.125 ounces per 1,000 feet of row
for soil application.
Do not apply more than I application
during the growing season.
Soil application at planting
(double band). Apply band on each
side of the furrow or transplant
row. Do not apply directly to seed.
OR
Postemergent soil application
ft (band). Apply as a sidedress after
plants are established.
Postemergent soil application
(double band). Apply as a
sidedress on each side of the row
after plants are established.
/22017BA Bermudagrass (seed crop)
IRACAAA
Aphids
0.6—1.2 oz/
IRAFAAA
Leafhoppers
1,000 ft row
ILAAABA
Mites
(5% G)
IMOAAAA
Thrips
/13005AA
Broccoli
IRACAAA
Aphids
1.1—1.125 oz/
INANADA
Flea beatles
1,000 ft row
IRAFAAA
Leafhoppers
(0.25—15% C)
ILAAABA
Mites
(6—8 lb/gal
IM OAAAA
Thrips
EC)
Issued: 5—11—82
111—032501—5
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EPA Index to Pesticide Chemicals
0, 0—DIETHYL S— [ 2-(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
Broccoli (continued)
IRACMA
INAMADA
IRAFAAA
ILAAABA
IMOAAAA
/13006AA
Brussels Sprouts
2 tsp 1% G or
1 tsp 2% Cl
plant
(1—2% G)
0.92 oz/2,500
sq. ft
(5—15% G)
(6—8 lb/gal
EC)
or
0.01 oz/lO ft
row
(1—2% C)
Soil application at planting. Mix
with soil in transplant hole before
setting Out plants.
0.75 ppm
Broadcast soil application to trans-
plant beds through 0.92 ounce per
2,500 square feet.
Do not make more than I application.
0.75 ppm
30 day preharvest interval through
1.125 ounces per 1,000 feet of row
for soil application.
Do not make more than 2 applications
during the growing season. t Allow a
minimum of 21 days between appUca—
tions.
Soil application at planting (double
band). Apply band on each side of
the furrow or transplant row. Do
not apply directly to the seed.
OR
Postemergent soil application
(band). Apply as a sidedress after
plants are established.
2 tsp 1% C or
1 tsp 2% Gf
plant
(1—2% C)
Soil application at planting. Mix
with soil in transplant hole before
setting Out plants.
Brussels Sprouts (transplant beds)
See Broccoli (transplant beds) cluster.
/I3005DA
/ 13006DA
/I3007DA
/ 13008DA
Broccoli (transplant beds)
Brussels Sprouts (transplant beds)
Cabbage (transplant beds)
Cauliflower (transplant beds)
Aphids
Flea beetles
Lea fhoppers
Mites
Thr i PS
Preplant broadcast soil application
to transplant beds. Incorporate
into top 2 to 3 inches of soil.
OR
Postemergent broadcast soil applica-
tion to transplant beds. Apply
granular over plants after emer-
gence. Water thoroughly.
IRACAAA
Aphids
1.1—1.125 oz/
INAMADA
Flea beatles
1,000 ft row
IRAFAAA
Leafboppers
(0.25—15% C)
ILAAABA
Mites
(6—8 lb/gal
IMOAAAA
Thrips
EC)
Issued: 5—11—82
111—032501—6
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EPA Index to Pesticide Chemicals
0, 0-DIETHYL S- [ 2-(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
0.75 ppm
42 day preharvest interval through
1.7 ounces per 1,000 feet of row
for soil application.
Do not make more than 2 applications
during the growing season. Allow a
minimum of 21 days between applica-
tions.
IRACABA
Root aphids
1.1—1.125 oz/
1,000 ft row
(0.25—15% G)
(6—8 lb/gal
EC)
or
0.01 oz/l0 ft
row
(1—2% G)
1.7 oz/1,000
ft row
(0.25—15% C)
(6—8 lb/gal
EC)
Soil application at planting
(double band). Apply band on each
side of the furrow or transplant
row. Do not apply directly to seed.
OR
Postemergent soil application
(band). Apply as a sidedress after
plants are established.
Cabbage (transplant beds)
Aphids
Lea fhoppers
Mites
Th rips
2 tsp 1% C or
I tsp 2% G/
plant
(1—2% G)
Soil application at planting. Mix
with soil in transplant hole before
setting out plants.
See Broccoli (transplant beds) cluster.
Soil application at planting
(double band). Apply band on each
side of seed furrow. Do not apply
directly on the seed.
OR
Postemergent soil application.
Apply by broadcast or as a
sidedress after plants are
established.
/ 13007AA Cabbage
IR.ACAAA
tNANADA
Aphids
Flea beetles
Aphids
Flea beetles
IRACAAA
INANADA
/28073BA
/14007BA
/ 14011 BA
/140 14BA
/ 28002 BA
IRACAAA
I RAFA.AA
ILAAABA
IMOAAAA
Carrots (seed crop)
Garlic (seed crop)
Onion (seed crop)
Radish (seed crop)
Turnips (seed crop)
N.F.
0.3—0.55 oz/
1,000 ft row
(5% C)
Issued: 5—11—82
111—032501—7
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EPA Index to Pesticide Chemicals
0, 0—DIETHYL S— [ 2—(ETHYLTHIO)EThYLJ PHOSPHORODITHIOATE
/ 13008AA
Site and Pest
Cauliflower
Dosages and
Formulation(s )
1.1—1.125 oz/
1,000 ft row
(0.25—15% G)
(6—8 lb/gal
EC)
or
0.01 oz/lO
row
(1—2% C)
Tolerance, Use, Limitations
0.75 ppm
40 day preharvest interval through
1.125 ounces per 1,000 feet of row
for soil application.
Do not make more than 2 applications
during the growing season. Allow a
minimum of 21 days between applica—
t ions.
Soil application at planting
(double band). Apply band on each
side of the furrow or transplant
row. Do not apply directly to seed.
OR
Postemergent soil application
ft (band). Apply as a sidedress after
plants are established.
2 tsp 1% C or
1 tsp 2% G/
plant
(1—2% G)
Soil application at planting. Mix
with soil in transplant hole before
setting out plants.
5 ppm (fresh clover)
12 ppm (clover hay)
7 day preharvest or pregrazing
interval through 1 pound per acre
for broadcast soil application.
Allow a minimum of 28 days between
applications.
N.F.
Allow a minimum of 21 days between
applications.
IRACAAA
INAMADA
IRAFA.AA
Aphids
Flea beetles
Leafhoppers
Cauliflower (transplant beds)
Cherry (nonbearing)
/23003AA Clover
See Broccoli (transplant beds) cluster.
See Apple (nonbearing) cluster.
IR.ACAAA
ILAAABA
Aphids
Mites
/23003BA Clover (seed crop)
IRACAAA
ILAAABA
Broadcast soil application. Repeat
as needed.
I lb/A
(5—15% C)
1.5 lb/A
(5—15% G)
Aphids
Mites
Broadcast soil application. Repeat
as needed.
Issued: 5—11—82
111—032501—8
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EPA Index to Pesticide Chemicals
0, 0-DIETHYL S- [ 2-(ETHYLTUIO)ETHYL] PHOSPHORODITHIOATE
/07002AA
Site and Pest
Coffee
Dosages and
Formulation(s )
Tolerance, Use, Limitations
0.3 ppm
90 day preharvest interval through
0.6 gram per foot of tree height.
Make no more than 1 pre— and 1 pos t—
harvest soil application. Do not
make more than 2 applications dur-
ing the year.
INAAAGA
Lea fminers
0.3—0.6 g/ft
of tree
height
c 5—l5Z G)
Use limited to PR.
Pre— and/or postharVest soil appli-
cation. Apply uniformly under tree
canopy.
Aphids
Mites
Corn rootworms
(adults)
0.3 ppm (grain including field corn
and sweet corn (kernels plus cob
with husk removed), popcorn)
5 ppm (fodder and forage (including
field corn, sweet corn, and pop-
corn))
28 day preharvest interval for
emulsifiable concentrate formula-
tions through 1 pound per acre for
foliar application.
40 day preharvest interval for
granular formulations through 1.2
ounces for 1,000 feet of row for
soil application.
Do not make more than 2 applica-
tions per season. Apply 1 foliar
and 1 soil application per crop
season.
Foliar application. For corn root—
worm adults apply when there is an
average of 3 to 5 beetles per plant.
INAMBHA
Corn rootworms
1.2 oz/1,000
ft row
(0.4—15% G)
(6—8 lb/gal
EC)
Soil application at planting (band).
Apply a 4 to 6 inch band directly
behind the planter shoe in front of
the press wheel. Emulsifiable con-
centrates applied with liquid fer-
tilizer apply split bands on each
side of the row. A second applica-
tion may be applied to the soil as
sidedress treatment later in the
season. Do not apply directly to
the seed.
/28005AA Corn
IR.ACAAA
ILAAABA
INANBHJ
0.5—1 lb/A
(6—8 lb/gal
EC)
Issued: 5—11—82
111—032501—9
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EPA Index to Pesticide Chemicals
0,0-DIETHYL S— [ 2—(ETHYLThIO)ETUYLI PHOSPHORODITHIOATE
IRACAAA
INANBHA
IRAFAAA
ILAAABA
IMOAAAA
IRACAAA
IRAFAAA
ILAAABA
IMOAAAA
Corn (continued)
Aphids
Corn rootworms
Lea fhoppers
Mites
Thrips
Aphids
Lea fhoppers
Mites
Thr p5
sand
Formulation(s )
1.2 oz/l,000
ft row
(l—15Z C)
(6—8 lb/gal
EC)
1.2 oz/l,000
ft row
(5—15% C)
0.75 ppm (cottonseed)
90 day preharvest interval (or up
to first squaring) through 2.4
ounces per 1,000 feet of row for
soil application.
28 day preharvest interval through
1.2 ounces per 1,000 feet of row for
soil application.
Do not make more than 2 postemer-
gent soil applications during the
crop season.
Allow a minimum of 21 days between
postemergent soil applications.
Foliar application prior to bloom
through 9 ounces per acre.
Do not make more than 3 foliar ap-
plications during the crop season.
If foliar applications are made do
not make soil applications within
the same crop year. Observe plant
response precaution.
0.75—1.2 oz/
1,000 ft row
(6—8 lb/gal
EC)
0.7—1.2 oz/
1,000 ft row
(0.25—15% C)
(6—8 lb/gal
EC)
Preplant soil application (band).
Apply a 16 inch band in a water
emulsion or with a preemergent
herbicide. Incorporate into soil.
OR
Soil application at planting
(band). Apply granular in or on
both sides of the furrow. Spray
emulsifiable concentrate on either
side of the seed or inject on each
side of the furrow.
OR
Site and Pest
Tolerance, Use, Limitations
Postemergent soil application
(band). Apply granular formulation
as a sidedress and emulsifiable con-
centrate on each side of the furrow.
Foliar application. Broadcast into
the whorl.
/28007AA Cotton
IRACAAA
IL .AAABA
IMOAAAA
Aphids
Mites
Thrips
Issued: 5—11—82
111—032501—10
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EPA Index to Pesticide Chemicals
0, O—D IETHYL s— [ 2—( ETHYLTHIO) ETHYL] PHOSPHORODITHIOATE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
Cotton (continued)
1.2—2.4 oz/
1,000 ft row
(5—15% C)
(6—8 lb/gal
EC)
Poatemergent soil application.
Apply in addition to at planting if
needed. Apply granular as a side—
dress or broadcast over the foliage.
Inject emulsifiable concentrate on
each side of the row. Allow a mini-
mum of 21 days between applications.
Apply preplant at planting and post—
emergent treatments as follows:
Light soils — 0.7 to 0.75 ounce
per 1,000 feet of row.
Medium soils — 1 ounce per 1,000
feet of row.
Heavy soils — 1.2 ounces per 1,000
feet of row.
OR
Postemergent soil application. Use
of granular formulations is limited
to irrigated cotton. Apply up to
first squaring (90 days before har-
vest). Apply in addition to at
planting application if needed.
Apply granular as a sidedress or
broadcast over the foliage. Ap-
ply emulsifiable concentrate on each
side of the row. Apply the lower
dosage rate for light soils andthe
higher rate for heavy soils.
0.375—0.5 oz/
1,000 ft row
(15% G)
Soil application to hill dropped
cotton at planting (band). Apply
with seed at planting. Apply lower
rate when hill spacing is greater
than 14 inches in the row or where
applications are made to light,
sandy soils.
Foliar application prior to bloom.
Repeat as needed.
IRACAAN
LMOAAAR
Aphids
Thrips
3—9 oz/A
(6—8 lb/gal
EC)
Issued: 5—11—82
1 1 1—03250 1— Il
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EPA Index to Pesticide Chemicals
0,0—DIETHYL S-(2—(ETHYLTUIO)ETHYL] PHOSPHORODITHIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Cotton (continued)
IRACAAA Aphids 4—8 oz/lOO lb Seed treatment. Apply ready to use
IMOAAAA Thrips 8eed with seed treating equipment. Apply
(9.14 lb/gal uniformly to cover all seeds. For
RTU) control of early season aphids and
thrips. For reduction of mites
ILAAABA (Mites) 8 oz/lOO lb during the critical period from
seed emergence to the 4 to 6 leaf stage.
(9.14 lb/gal If the low rate is used, control
RTU) may be impaired if treated seed is
carried over to the next growing
season. Repeat treatment using the
low rate the following season to
ensure maximum insect control.
Properly label treated seed. Treat-
ed seeds exposed to soil surface
will be hazardous to birds and wild-
life.
Crabapple (nonbearing)
See Apple (nonbearing) cluster.
Garlic (seed crop) See Carrots (seed crop) cluster.
/08020AA Hops - 0.5 ppm
Soil application through 4 pounds
per acre or 0.072 ounce per plant
for standard 7 foot by 7 foot
hopyard spacing.
Do not graze or feed crop refuse to
livestock.
IRACAAA Aphids 2—4 lb/A Soil application. Apply in a 6 inch
ILAAABA Mites OR square at the base of each plant.
0.036—0.072 Apply mid to late June just prior
oz/plant to the hilling. Hilling operation
[ 7 ft by should cover granules with soil.
7 ft hopyard Irrigate as normal crop culture re—
spacing] quires.
(15% G)
Issued: 5—11—82 111—032501—12
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EPA Index to Pesticide Chemicals
0,0-DIETHYL S-E2—(ETHYLTHIO)ETHYL PHOSPHORODITHIOATE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
/28062AA Oats
/28063AA
0.56—1.2 oz/
1,000 ft row
(0.25—15% G)
(.6—8 lb/gal
EC)
or
0.008—0.012
oz/l0 ft row
(1—2% C)
0.75 ppm
60 day preharvest interval through
1.2 ounces per 1,000 feet of row for
soil application.
Do not apply to transplanted let-
tuce. Observe plant response pre-
caution.
Soil application to spring or sum-
mer seeded lettuce at planting (dou-
ble band). Apply band on each side
of furrow. Do not apply directly
on seed. Apply higher rate on heavy
organic soils.
Postemergent soil application to
fall or winter seeded lettuce
(band). Apply as a sidedressing at
thinning time.
0.75 ppm (grain)
5 ppm (green fodder and straw)
60 day preharvest interval (grain)
through 1 pound per acre for soil
application.
30 day pregrazing or preharvest
interval (forage, fodder) through I
pound per acre for soil application.
Do not apply more than 2 times er
crop season. Allow a minimum of 21
days between postemergent soil ap-
plications. Observe resistance
statement.
Soil application at planting. Apply
as a soil injection.
/13020AA Lettuce
IRACAAA Aphids
IR.AFAAA Leafhoppers
LAAABA Mites
IMOAAAA Thrips
Aphids
Mites
Onion (seed crop)
Peach (nonbearing)
.RACAAA
ILAAABA
I lb/A
(0.4—15% G)
1 lb/A
(6—8 lb/gal
EC)
Soil application at planting by
broadcast or drilling.
OR
Postemergent broadcast soil appli-
cation.
See Carrots (seed crop) cluster.
See Apple (nonbearing) cluster.
Issued: 5—11—82
tiI—03250 1—13
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EPA Index to Pesticide Chemicals
0,0-DIETHYL S— [ 2—(ETHYLTHIO)ETRYL] PHOSPHORODIThIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s )
_______ 0.75 ppm (peanuts)
0.3 ppm (peanut hulls)
5 ppm (peanut hay)
Broadcast soil application (prep—
lant) through 6 pounds per acre.
Do not make more than 1 broadcast
soil application during the growing
season.
Banded soil application (at pegging)
through 2.25 ounces per 1,000 feet
of row.
Do not tank mix with phosalone.
Preplant broadcast soil application.
Incorporate to a depth of 3 to 6 in-
ches by disc or other suitable
equipment.
Soil application at planting (double
band). Apply on each side of the
seed furrow. Do not apply directly
on the seed.
Postemergent soil application (side—
dress). Apply after plants are
established.
Soil application at pegging. Apply
if needed.
Pear (nonbearing) See Apple (nonbearing) cluster.
/28015AA Peanuts
IMOAAAA
IRACAAA
IRAFAAA
ILAA.ABA
IMOAAAA
Thrips 6 lb/A
(6—8 lb/gal
EC)
Aphids
Leafhoppers
Mites
Thrips
1.1—2.25 oz/
1,000 ft row
(l.33—l5 C)
(6—8 lb/gal
EC)
OR
OR
Issued: 5—11—82
111—032501—14
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EPA Index to Pesticide Chemicals
0, O-D IETHYL S- [ 2—( ETHYLTHIO) ETHYL] PHOSPHORODITHIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s )
/28075AA Peas 0.75 ppm
5 ppm (pea vines)
50 day preharvest interval through
2.5 pounds per acre.
Do not make more than 1 application
during the growing season.
IRACAAA Aphids 1—2.5 lb/A Soil application at planting.
IRAFAAA Leafhoppers (0.5—15% C) Apply granular by drilling or
(6—8 lb/gal broadcasting. Apply emulsifiable
EC) concentrate as an in furrow spray
or as an injection on each side of
the furrow.
OR
Postemergent soil application
(band). Apply as a sidedress after
plants are established.
0.01% oz/lO Soil application at planting (double
ft row band). Apply band on each side of
(1—2% G) furrow.
/03008AA Pecan 0.75 ppm
80 day preharvest interval through
3 pounds per acre for soil applica-
tion. Do not make more than 1 soil
application during the growing
season.
30 day preharvest interval throUgh
1.5 pounds per acre for foliar
application. Do not make more than
3 foliar applications during the
growing season.
Do not allow livestock to graze
under treated trees.
Do not tank mix with phosalone.
IRACAAA Aphids 1—3 lb/A Use limited to central and south—
(15% C) western states.
(6—8 lb/gal Soil application (double band). Ap—
EC) ply 6 foot bands on both sides of
trees under the main drip area. In-
corporate into the upper 2 to 3 in-
ches of soil. For irrigated pecans
apply water as soon as possible af-
ter treatment. Apply in early
spring.
Issued: 5—11—82 111—032501—15
-------
EPA Index to Pesticide Chemicals
0 ,0—DIETHYL S— [ 2—(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Pecan (continued)
0.25—0.375 Foliar application. Repeat as
ib/ICO gal needed.
[ up to 400
gal/Al
(6—8 lb/gal
EC)
0.75—1 lb/A Foliar application by aircraft. Ap—
(6 lb/gal EC) ply in a minimum of 5 gallons of
water per acre.
/28017AA Peppers
This use only occurs on 24(c) Spe-
cial Local Need labeling and has not
been included in this entry. Refer
to appropriate labeling for use in-
formation.
/06013AA Pineapple 0.75 ppm (pineapple)
5 ppm (pineapple foliage)
5 ppm (pineapple bran)
60 day preharvest interval through
2.5 pounds per acre when 2 applica-
tions are made. Do not make more
than 2 applications during crop
period.
Do not ensile foliage less than I
year after last application when 2
applications are made.
IRAWAA.A Mealybugs 2.5 lb/A Soil application. Apply as a broad—
(5—15% G) cast application or apply topically
by base leaf feeding after plants
have developed root system.
2.5 lb/A Use limited to III.
(6—8 lb/gal Soil application. Apply with liquid
EC) fertilizer as a soil injection.
Plum (nonbearing) See Apple (nonbearing) cluster.
Issued: 5—11—82 111—032501—16
-------
EPA Index to Pesticide Chemicals
0,0-DIETRYL s- [ 2-(ETHYLTHIO)ETHYL] ?HOSPHORODITHIOATE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
Aphids 3—4 lb/A
(5—15% C)
(6—8 lb/gal
EC)
0.75 ppm
30 day preharvest interval through
1 pound per acre for foliar or
sprinkler irrigation application.
Do not make more than 3 foliar or
sprinkler irrigation applications
during the growing season.
60 day preharvest interval through
3 pounds per acre for sprinkler
irrigation application. Do not make
more than 1 sprinkler irrigation
application during the growing sea-
son.
75 day preharvest interval through
3.5 ounces per 1,000 feet of row for
soil application. Do not make more
than 2 soil applications during the
growing season.
Do not tank mix with phosa].one.
Preplant broadcast soil application.
Incorporate to a depth of 2 to 3
inches by disc or other suitable
equipment.
IRACAAA
INAMCFA
INANADA
IRAFAAA
IRAXAHA
tNAVAFA
Aphids
(Colorado potato
beetle (early
season))
Flea beetles
(except tuber flea
beetles)
Lea fhopper s
Potato psyllid
Southern potato
weevil
2.25—3.5 oz/
1,000 ft row
(0.25—15% C)
(6—8 lb/gal
EC)
0.024—0.036
oz/lO ft row
(1—2% G)
I R.ACCUA
Green peach aphid
0.375—1 lb/A
(6—8 lb/gal
EC)
Foliar application. Apply when pest
first appears. Apply higher rates
for heavy infestation. Repeat as
needed. In AZ and CA do not apply
to the Centennial variety.
/ I4O13AA Potato
ERACAAA
or
Soil application at planting (double
band or in furrow). Apply in the
furrow or in a band on each £side of
the furrow. Spray emulsifiable con—
centrate when applying in furrow.
OR
Postemergent soil application
(band). Apply as a sidedress after
plants become established. Apply
higher rate on organic soils.
Issued: 5—11—82
111—032501—17
-------
EPA Index to Pesticide Chemicals
0, 0-DIETHYL S— [ 2—(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Potato (continued)
INAIICFA Colorado potato 1—3 lb/A Use limited to CA, ID, OR, UT, and
beetle (6—8 lb/gal WA.
IRACCUA Green peach aphid EC) Sprinkler irrigation application.
Solid set systems , apply during the
entire length of the irrigation
period, or for a 30 to 60 minute
period at the end of a regular
irrigation set, or as a 30 to 60
minute irrigation as a separate
application not associated with
regular irrigation.
Center pivot systems , inject
continuously for I complete revolu-
tion of the system. Do not apply
when wind velocities exceed 10 miles
per hour.
Prune (nonbearing) See Apple (nonbearing) cluster.
Radish (seed crop) See Carrots (seed crop) cluster.
/O1006DA Raspberry (nursery stock) N.F.
IRACAAA Aphids 8 lb/A Use limited to Northeast states.
(15% G) Soil application to new or estab-
lished plantings (band). Apply 24
inch band over row. Incorporate
into top 2 to 3 inches of soil using
a cultivator or other suitable
equipment. A second soil applica-
tion may be made later in the sea-
son. Consult state agriculture
extension service for proper timing.
/28020AA Rice 0.75 ppm (rice)
5 ppm (rice straw)
100 day preharvest interval through
2 pounds per acre for broadcast soil
application.
Do not make more than 2 applications
during the growing season.
IRAFAAA Leafhoppers 2 lb/A Broadcast soil application at plant—
(5—15% C) ing or prior to flooding.
Issued: 5—11—82 111—032501—18
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EPA Index to Pesticide Chemicals
0, 0—DIETHYL S— [ 2—(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
0.9—1.2 oz/
1,000 ft row
(0.625—15% C)
(6—8 lb/gal
EC)
1.2 oz/l,000
ft row
(5—15% G)
(6—8 lb/gal
EC)
0.75 ppm (grain)
5 ppm (fodder and forage)
30 day preharvest interval for
granular formulations through 1.2
ounces per 1,000 feet of row for 3
foliar applications and 1 soil
application (grain).
14 day preharvest/pregrazing inter-
val for granular formulations
through 1.2 ounces per 1,000 feet
of row for 3 foliar applications
and 1 soil application (fodder and
forage).
34 day preharvest/pregrazing inter-
val for emulsifiable concentrate
formulations through 0.5 pound per
acre for 3 foliar applications and
2 soil applications (grain and for-
age and fodder).
7 day preharvest interval for emul-
sifiable concentrate formulations
through 1 pound per acre for 2
foliar applications when no soil
applications have been made (grain).
28 day preharvest/pregrazing inter-
val for emulsifiable concentrate
formulations through 1 pound per
acre for 2 foliar applicatio is when
no soil applications have been made
(forage and fodder).
Observe resistance statement.
Soil application at planting (in
furrow). Apply 0.5 inch above seed.
Do not apply directly on the seed.
Soil application at planting (band).
Apply a 4 to 6 band inch behind
planter shoe in front of press
wheel. Do not apply directly on
the seed.
/28O19AA
IRACDNA
Greenbug
Issued: 5—11—82
111—032501—19
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EPA Index to Pesticide Chemicals
0 ,0—DIETHYL S—(2—(ETHYLTHIO)EThYLJ PHOSPHORODITUIOATE
Site and Pest
Sorghum (continued)
Dosages and
Formulation(s )
1.2 oz/l,000
ft row
(5—15% G)
Tolerance, Use, Limitations
Foliar application. Broadcast into
whorls.
1.2 oz/l,000
ft row
(6—8 lb/gal
EC)
0.25—0.5 lb/A
(6—8 lb/gal
EC)
Postemergent soil application (side—
dress). Inject into the row on both
sides of the furrow any time up to
boot stage.
Foliar application.
I OANAIA
Sorghum midge
0.25—0.5 lb/A
(6—8 lb/gal
EC)
Use limited to AR, LA, OK, and TX.
Foliar application. Apply when 50
percent of the 8eed heads emerge
from the boot. Make second applica-
tion 3 to 5 days later.
ILAVANA
Banks grass mite
0.5—1 lb/A
(6—8 lb/gal
EC)
Use limited to OK and TX, excluding
the Trans Pecos area.
Foliar application. Apply in a
minimum of 1 gallon of water per
acre by aircraft or in a minimum of
5 gallons of water per acre by
ground equipment.
0.1 ppm (soybeans)
0.25 ppm (forage and hay)
Banded soil application (at time of
planting) through 1.2 ounces per
1,000 feet of row.
Do not apply directly on the seed.
Soil application at planting (band
or double band). Apply a 4 inch
band over the seed furrow behind
the planter shoe in front of the
press wheel or apply a band on each
side of the seed furrow.
/28023AA Soybeans
INAPAFA
IMOAA.AA
Mexican bean beetle
Thrips (excluding
flower thrips)
1.2 oz/l,000
ft row
(5—15% G)
Issued: 5—11—82
111—032501—20
-------
EPA Index to Pesticide Chemicals
0,0—DIETHYL S— [ 2—(ETHYLTUIO)ETHYLJ PHOSPHORODITHIOATE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
/ 28023 BA
IR.ACAAA
IRAFAAA
ILAAABA
M0AAAA
Soybeans (seed crop)
N.F.
Do not pasture or use treated crop
for feed, food, or forage.
Soil application to seed crop at
planting (double band). Apply in a
band on each side of the seed fur-
row. Do not apply directly on the
seed.
Postemergent soil application to
seed crop (band). Apply as a side—
dress after plants are established.
Spinach 0.75 ppm
Banded soil application (at time of
planting) through 0.6 ounce per
1,000 feet of row.
0.6 oz/l,000
ft row
(0.4—15% C)
(6—8 lb/gal
EC)
or
0.006 oz/
10 ft row
(1—2% C)
/ 0101 6DA
Strawberries (propagating plants)
N.F.
Do not use fruit from treated
plants for food purposes.
Soil application. Apply granular
by sidedressing on each side of the
row or by broadcasting over the row.
Apply emulsifible concentrate as a
soil injection on each side of the
row. Repeat as needed.
RACAAA
Aphids
1.2 oz/l,000
£RAFAAA
Leafhoppers
ft row
ILAAABA
Mites
(5—15% C)
IMOAAAA
Thrips
/ 13024AA
OR
Aphids
Lea fhoppers
Mites
Thr i PS
Soil application at planting (double
band). Apply in a band on each side
of the seed furrow. Do not apply
directly on the seed.
IRACAAA
Aphids
2.55—5.2 oz/
U.AAABA
Mites (except
cyclaman mite)
1,000 ft row
(5—15% G)
(6—8 lb/gal
EC)
Issued: 5—11—82
111—032501—21
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EPA Index to Pesticide Chemicals
0, 0-DIETHYL S— ( 2—( ETIIYL.ThIO) EThYL] PHDSPHORODIThIOATE
/ 28020AA
Site and Pest
Sugar Beets
Dosages and
Formulation(s )
0.9 oz/l,000
ft row
(0.25—15Z G)
(6—8 lb/gal
EC)
Tolerance, Use, Limitations
0.5 ppm (sugarbeets)
2 ppm (tops)
5 ppm (dehydrated sugar beet pulp)
30 day preharveat interval through
0.9 ounces per 1,000 feet of row
for soil application.
Do not apply more than 3 applica-
tions during growing season. Allow
a minimum of 21 days between post—
emergent soil applications. Observe
plant response precaution.
Soil application at planting (in
furrow). Apply in seed furrow 2
inches under the seed. Do not apply
directly on the seed.
Soil application at planting (double
band). Apply in a band on both
sides of the furrow. Do not apply
directly on the seed.
Postemergent soil application.
Apply granular to foliage and crown.
Apply emulsifiable concentrate as a
sidedress after plants are estab-
lished.
IOAC ABA
Root maggots
0.675—0.7 oz
1,000 ft row
(l0—l5 C)
Use limited to MN and ND.
Soil application at planting (band).
Apply 4 to 6 inch band directly be-
hind planter shoe in front of the
press wheel. The granules should
be placed 1 inch above the seed.
Do not apply directly on the seed.
Aphids 6—9 az/A
(6—8 lb/gal
EC)
0.3 ppm
28 day preharvest interval through
9 ounces per acre for foliar appli-
cation.
Do not make more than 4 applications
during the growing season.
Use limited to PR.
Foliar application. May be applied
by aircraft in approximately 4 gal—
ions of water per acre. Apply when
pest first appears.
IRACAAA
IRAFA.AA
ILAAABA
Aphids
Lea fhoppers
Mites
OR
OR
125003AA Sugarcane
IRACAAA
Issued: 5—11—82
111—032501—22
-------
EPA Index to Pesticide Chemicals
0,0-DIETHYL S- [ 2—(ETHYLThIO)ETHYLI PHOSPHORODITHIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s )
/26003AA Tobacco N.F.
/26006AA Do not make more than 1 application
during the growing season.
IRACAAA Aphids 3—4 lb/A Preplant broadcast soil application.
INANADA Flea beetles (1.33% C) Apply immediately before transplant—
INAVAFA (Southern potato ing and incorporate into the top 2
wireworm) to 3 inches of soil.
3—6 oz/l,000 Preplant soil application (band).
ft row Apply 6 to 12 inch band over the
(5—15% C) row, incorporate into top 2 to 3
inches of soil, set transplants
into the treated row.
OR
Preplant broadcast soil application.
Incorporate into top 2 to 3 inches
of soil.
INANADA Flea beetles 4 lb/A Preplant broadcast soil application.
(6—8 lb/gal Incorporate into the top 2 to 3 in—
EC) ches of soil.
/26006AA (Tobacco Flue Cured)
IRACAAA Aphids 4 lb/A Use limited to GA and VA.
(6 lb/gal EC) Preplant broadcast soil applica-
tion. Incorporate into the top 2
to 3 inches of soil.
/26003DA Tobacco (transplant beds) N.F.
Do not apply more than I application
to transplant bed.
IRACAAA Aphids 3.75 oz/2,500 Preplant broadcast soil application.
INANADA Flea beetles sq. ft Incorporate into top 2 to 3 inches
(10—15% G) of soil.
OR
Postemergent broadcast soil applica-
tion. Apply over plants after emer-
gence and water thoroughly.
Issued: 5—11—82 111—032501—23
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EPA Index to Pesticide Chemicals
0, 0-DIETHYL s—(2—(EmYLThI0)ETIWLI PHOSPHORODIThIQATE
/ 1IOO5AA
Site and Pest
Tomato
Dosages and
Formulation(s )
Tolerance, Use, Limitations
0.75 ppm
30 day preharvest interval through
11 ounces per 1,000 feet of row (72
inch row spacing) for soil applica-
tion. Do not make more than 1
application during the growing
season.
30 day preharvest interval through
5.5 ounces per 1,000 feet of row
(72 inch row spacing) for soil
application. Do not make more than
2 applications during the growing
season.
Observe plant response precaution.
I.RACAAA
INAZICFA
IRAFAAA
IMAAAGA
ILAAABA
Aphids
(Colorado potato
beetle (early sea-
son))
Lea fhopper s
Leafminers
Mites
1.2—3.5 oz/
1,000 ft row
El applica-
tion]
1.2—2.4 oz/
1,000 ft row
[ 2 applica-
tions]
(0.25—15% G)
(6—8 lb/gal
EC)
3.5—11 oz/
1,000 ft row
[ 72 in. row
spacing)
El applica-
tion)
or
2.4—5.5 oz/
1,000 ft row
(72 in. row
spacing]
[ 2 applica-
tions]
(5—15% G)
(6—8 lb/gal
EC)
Use limited to highly alkaline soils
in FL.
Soil application at planting (double
band). Apply band on each side of
seed furrow or transplant row.
Do not apply directly on the seed.
OR
Postemergent soil application
(band). Apply as a sidedress. Al-
low a minimum of 21 days between ap-
plications.
or
Soil application at planting (double
band). Apply band on each side of
seed furrow or transplant row.
Do not apply directly on the seed.
OR
Postemergent soil application
(band). Apply as a sidedress. Al-
low a minimum of 21 days between ap—
plicat ions.
Issued: 5—11—82
111—032501—24
-------
EPA Index to Pesticide Chemicals
0,0—DIETHYL S— [ 2—(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
Tomato (continued)
-IRACAAA Aphids 0.02—0.036 Soil application at planting (double
INANADA Flea beetles oz/lO ft row band). Apply band on each side of
IRAFAAA Leafhoppers [ 1 applica— seed furrow. Do not apply directly
IMAAAGA Leafminers tion on the seed.
ILAAABA Mites (1—2% G) OR
or Postemergent soil application (dou—
0.02 oz/l0 ft ble band). Apply band on each side
row of row as sidedress. Allow 21 days
[ 2 applica— between applications.
.tions)
(2% C)
4 tsp 1% G Soil application to transplant hole.
or Mix with soil before setting plant.
2 tsp 2% C/
plant
(1—2% C)
/I1005DA Tomato (transplant beds) 0.75 ppm
Broadcast soil application to trans-
plant beds through 3 pounds per
acre.
Do not make more than I application.
IRACAAA Aphids 2.75 oz/2,500 Preplant broadcast soil application
INA14CFA (Colorado potato sq. ft to transplant beds. Incorporate
beetle (early (5—15% G) into top 2 to 3 inches of soil.
season)) (6—8 lb/gal OR
LRAFAAA Leafhoppers EC) Postemergent broadcast soil applica—
IMAAAGA Leafminers tion to transplant beds. Apply
ILAAABA Mites granular over plants after emer-
gence. Water thoroughly.
Turnips (seed crop) See Carrots (seed crop) cluster.
Issued: 5—11—82 111—032501—25
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EPA Index to Pesticide Chemicals
0 ,O—DIETHYL S— [ 2-(ETHYLTHIO)ETHYL] PHOSPHORODITHIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s )
/28065AA Wheat 0.3 ppm (grain)
5 ppm (green fodder and straw)
30 day preharvest interval through
0.75 pounds per acre for foliar ap-
plication.
For emulsifiable concentrate formu-
lations:
Fall application . Two applications
may be made. Allow 30 days between
applications.
Spring application . Application at
green up may be made following fall
applications. An additional spring
application may be made 30 days fol-
lowing the first spring application.
Observe resistance statement.
IRACDNA Greenbug 0.25—0.75 Use limited to AL, TN, and all
ILAAABA Mites lb/A states west of the MI River.
(6—8 lb/gal Foliar application. Apply the lower
EC) rates up to tillering (stooling)
and higher rates after plants begin
to tiller.
0.375—0.75 Use limited to AL, TN, and all
lb/liquid states west of the MI River.
fertilizer/A Foliar application. Apply as a top—
(6—8 lb/gal dress by ground equipment.
EC)
0.75 lb/A Broadcast application. Apply as a
(0.75% G) topdress any time after crop is well
established.
IRACAAA Aphids (including 1 lb/A Broadcast soil application at fall
greenbug, oat (0.4—1% C) planting.
bird, cherry) or OR
IVABAAA Grasshoppers 0.25 oz/l,000 Soil application at fall planting
IDAHAQA Hessian fly ft row (band). Apply 3 inch bands by
(5—15% C) drilling granular formulations.
(6—8 lb/gal
EC)
Issued; 5—11—82 111—032501—26
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EPA Index to Pesticide Chemicals
0, 0—D IETHYL S— [ 2- ( ETHYLTUIO ) ETHYL] PHO SPROROD ITHIOATE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
/3I000AA
ORNANENTALS
General Warnings and Limitations : Preplant treatments to flowers, shrubs,
and trees. Apply evenly to seed bed and incorporate into soil. Plant in
usual manner. Established plants may be treated by applying uniformly
under foliage canopy. Incorporate into topsoil and water to accelerate
entry into the plant. In commercial topping of flowers by hand, clean
gloves (cotton or natural rubber) should be worn. When applying in green-
houses or other enclosed areas wear a respirator jointly approved by the
Mining Enforcement and Safety Administration (formerly the United States
Bureau of Mines) and by the National Institute for Occupational Safety
and Health.
( Ornamental Plants (herbaceous, woody shrubs, trees and vines)
Ornamental Ilerbaceous Plants
I tsp 2% Cl
plant
(1—2% c)
0.053—0. 107
ozllO sq ft
(1—2% C)
Preplant broadcast soil application.
Incorporate into the top 1 to 3
inches of soil.
Soil application. Apply around
base of established plants.
Soil application to established
plants (band). Apply near base of
plants. Apply higher rate on muck
or heavy organic soils.
5.3—10.7 oz/
1,000 ft row
(5—15% G)
Soil application
Apply band over,
side of the row.
on muck or heavy
at planting (band).
the row or on each
Apply higher rate
organic soils.
/31093AA
/ 31111 AA
IRACAAA
IQAXAAA
I RAFAAA
ILAAABA
IMOAAAA
IRA BAAA
(Easter Lily)
(Gladiolus)
Aphids
Lacebugs
Lea fhoppers
Mites
Thrips
Whitef lies
5.3—10.7 oz/
1,000 ft row
(5—15% C)
Refer to (Ornamental Houseplants), Ornamental
Herbaceous Plants for additional information.
IRACAAA
Aphids
0.08—0.48 ozl
IQAXAAA
Lacebugs
100
sq ft
IRAFAAA
Leathoppers
(1—2%
G)
ILAAABA
Mites
IMOAAAA
IRABAAA
Thrips
Whiteflies
2 tsp
or
1%
C
Soil application at planting (in
furrow). Apply over bulbs before
covering with soil. Do not apply
in furrow application to garden lily
bulbs. Apply higher rate on muck
or heavy organic soils.
IssuedI 5—11—82
111—032501—27
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EPA Index to Pesticide Chemicals
0, 0—D IETMYL S— [ 2—( ETHYLTHIO) ETI4YL] PHOSPHOROD ITHIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s )
/35000AA Ornamental Trees
/34004AA Ornamental Woody Shrubs
/34120AA
IRACAAA Aphids 0.02 ozf ft of Soil application to established
INAMOAA Elm leaf beetle growth plants. Incorporate into top 1 to
IQAXAAA Lacebugs [ plants 1—3 2 inches of soil. Repeat at 28 to
IRAFAAA Leafhoppers ft] 42 day intervals.
INAAAGA Leafminers or
ITAOACA Mimosa webworms 0.04 oz/ft of
ILAAABA Mites growth
ITBGACA Pine tip moth/Pine [ plants 3—6
shoot moths ft]
IRAAABA Scales or
IMOAA.AA Thrips 0.06 ozfft of
IRABAAA Whiteflies growth
[ plants 6—12
ft I
or
0.24 oz/in. of
tree trunk
diameter
(0.99—2% G)
0.5carcrige Soil application to established
2% P/T/3 ft plants. Attach provided root feeder
of growth to garden hose and use a gentle
and flow of water. Apply evenly under
0.5 cartrige/ drip line. Begin application in
additional early spring when new growth appears
ft of growth and repeat at 42 day intervals as
(2% P/T) needed. For trees, insert root
feeder into root zone. For shrubs,
insert root feeder up to 12 to 14
inches in the ground. For shallow
rooted plants do not insert as deep
but never less than 6 inches.
(Rose)
IRACAAA Aphids 0.016—0.03 oz Soil application at planting.
IQAXAAA Lacebugs /plant Divide dosage and apply to bottom
IRAFA.AA Leafhoppers (0.99—1% C) of hole and the remainder to the top
IMAA.AGA Leafminers 2 inches of soil. Water thoroughly.
ILAAABA Mites
IRAAABA Scales
IMOAAAA Thrips
IRABAAA Whiteflies
Issued: 5—11—82 111—032501—28
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EPA Index to Pesticide Chemicals
0,0—DIETIIYL S—(2-(ETUYLThIO)EThYL] PHOSPRORODITHIOATE
Site and Pest
Dosages and
Formulation(s )
Tolerance, Use, Limitations
Ornamental Trees cluster (continued)
0.02 oz/plant
(polyantha
and hybrid
tea roses)
or
0.04 oz/plant
(bush roses]
or
0.08 oz/plant
climbers
(1% C)
0.32 oz/l00
sq ft
(0.99% G)
Soil application to e8tablished
plants. Incorporate into top 1 to
2 inches of soil. Apply when 1 inch
of growth appears in the spring.
Repeat at 42 day intervals.
ERACAAA
INANOAA
IQAXAAA
IRAFAAA
IMAAACA
ITAOACA
tLAAABA
ITBCACA
IRAAABA
IMOAAAA
I RABAAA
Aphids
Elm leaf beetle
Lacebugs
Leafhoppers
Leafminers
Mimosa webworms
Mites
Pine tip moth/Pine
shoot moths
Scales
Thrips
Whiteflies
0.375—4 oz/
plant
or
0.375 oz/in.
of tree
trunk
d lame t er
(5—15% C)
1.07—2.5%
clay slurry
(10—15% G)
Soil application to established
plants. Apply higher per plant
dosage for muck or heavy organic
soils.
Soil application at planting. Apply
equivalent amount to transplant
hole.
Root dip prior to planting.
or
/35 000DA
/ 34004DA
130006AA
Ornamental Trees
Ornamental Woody
(nursery stock)
Shrubs (nursery stock)
Issued: 5—11—82
111—032501—29
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EPA Index to Pesticide Chemicals
0, O-D IETHYL s— [ 2—( ETHYLTEIO ) ETHYL] PHOSPHOROD ITILIOATE
Site and Pest Dosages and Tolerance, Use, Limitations
Formulation(s)
( Ornamental Houseplants )
/3 I000AA Ornamental Herbaceous Plants
(Houseplants)
IRACAAA Aphids 2 tsp 1% C Soil application to potted plants.
IQAXAAA Lacebugs or Thoroughly mix with soil and drench
IRAFAAA Leafhoppers 1 tsp 2% G/ with water.
IMAAAGA Leafminers 6 in. pot
IRAWAAA Mealybugs (1—2% G)
ILAAABA Mites or
IRAAABA Scales 2 tsp 2% C
IMOAAAA Thrips 8 in. pot
IRABAAA Whiteflies or
I tbls 2% C
10 in. pot
(2% G)
FOREST, CHAPARRAL, NONAGRICULTURAL AND WASTELANDS
/30006AA Forest Plantings
Refer to ORNAMENTALS, Ornamental Trees (nursery
stock) cluster.
9999999 AERIAL, MOTHPROOFING AND TANK MIX APPLICATIONS
9001500 Aerial Application
AAAAAAA
Refer to
AGRICULTURAL CROPS
Alfalfa, Alfalfa (seed crop), Bar—
ley, Clover, Clover (seed crop),
Corn, Oats,_Peanuts, Peas, Pecan,
Pineapple, Potato, Rice, Sorghum,
Sugarcane, Tobacco, Tobacco (flue
cured), Wheat
Issued: 5—11—82 111—032501—30
-------
EPA Index to Pesticide Chemicals
0, 0-D IETHYL s- [ 2-(ETHYLTHIO ) ETHYL] PHOSPHOROD ITHIOATE
Listing of Registered Pesticide Products by Formulation
95% technical chemical
00, diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
003125—00183
2% formulation intermediate
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
003125—00120
2.2% formulation intermediate
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
009649—00003
5% formulation intermediate
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
003 125—00 130
68% formulation intermediate
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
003125—00158
0.25% granular
0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
006735—00158 010501—00001
0.28% granular
0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
042057—00069
0.33% granular
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
010554—00002
0.4% granular
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
002124—00408
0.5% granular
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
000912—00043 003120—00006 006735—00161 007192—00006
010501—00002 010554—00003
0.625% granular
0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
003120—00007 007001—00115
0.672 granular
0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
000912—00040
Issued: 5—11—82 111—032501—31
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EPA Index to Pesticide Chemicals
0,0-DIETHYL S- [ 2—(ETHYLTHIO)ETHYL] PHOSP}LORODITUIOATE
Listing of Registered Pesticide Products by Formulation (continued)
0.75% granular
0,0, —diethy]. S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
006735—00 160 007192—00008 0 10554—0004
0.8% granular
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
003120—00008
0.99% granular
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
007401—00004
1% granular
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
000004—00253 000192—00126 000239—02134 000802—00426
000869—00076 000904—00138 000912—00042 002125—00042
003120—00009 003125—00152 003770—00196 005719—00079
005887—00061 008660—00004* 006735—00159 007001—00313
007192—00005 007401—00235 009404—00003 010554—00001
010554—00005 033313—00004* 04205 7—00051 42057—00052
*jacket currently unavailable for review
1.33% granular
0 ,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
006735—00199
2% granular
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
000004—00153 000192—00074 000192—00119 000602—00146
000769—00515 001685—00049 001769—00167 003125—00083
003125—00 116 003125—00126 005605—00102 007401—00026
008222—00036 033955—00490 045085—00021
5% granular
0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
003125—00058
10% granular
0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
003125—00061
15% granular
0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
000226—00 192 002393—00423* 002749—00233 003125—00172
*jacket currently unavailable for review
2% pelleted/tableted
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
009649—00001
Issued: 5—11—82 111—032501—32
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EPA Index to Pesticide Chemicals
0 ,0—DIETHYL S— [ 2—(ETHYLThIO)ETHYL] PHOSPHORODITHIOATE
Listing of Registered Pesticide Products by Formulation (continued)
6 lb/gal emulsifiable concentrate
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) plus
aromatic petroleum solvent (006601)
003125—00119
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) plus
xyleae (086802)
002749—00290
8 lb/gal emulsifiable concentrate
0,0,—diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501) plus
aromatic petroleum solvent (006601)
003125—00307
95 ready—to—use
0,0, —diethyl S—(2—(ethylthio)ethyl) phosphorodithioate (032501)
003125—00173
State Label Registrations
AZ Reg. No.
001526—03794 002935—09021 003125—07856 003125—07857
CA Reg. No.
003125—07840 00700 1—07725 007001—07738 007001—07739
007001—07740 007001—07741 007001—07742 011149—04662
0 11149—04664
GA Reg. No.
00673 5—08 174
HI Reg. No.
0 3784 3—08 5 70
ID Reg. No.
003 125—07833
OR Reg. No.
000483—04584 000483—04585 000483—04586 000483—04587
000483—04588 000483—04589 001871—08933 00187 1—09816
00187 1—09817 00187 1—09818 00187 1—09823 011656—05895
035497—04491 035497—04492
WA Reg. No.
003125—07827
WI Reg. No.
021713—10125 021713—10134 035329— 10124
Issued: 5—11—82 111—032501—33
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EPA Index to Pesticide Chemicals
0, O—D IETHYL s— [ 2— ( ETHYLTHIO ) ETHYL] PHOSPHOROD ITHIOATE
Appendix A
Listing of Common Chemical Names TJsed on the Entry
Chemical Con non Name EPA Acceptable
Code (source) Common/Chemical Name
032701 fensulfothion o,o—diethyl o— [ p—(inethylaulfynl) phenyl]
phosphorothioate
Issued: 5—11—82 111—032501—34
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II. REQUIREMENT FOR SUBMISSION OF GENERIC DATA
A. This portion of the guidance document is a Notice issued
under the authority of FIFRA sec. 3(c)(2)(B) and describes,
in table format, the data required for maintaining the registra—
bility of each product. Additionally, a bibliography (Appendix
11—2) is included that identifies that data considered as part
of the data base supporting this standard. EPA has determined
that additional generic data described in this Notice must be
submitted to EPA for evaluation in order to maintain in
effect the registration(s) of your product(s) identified as
an attachment to the cover letter accompanying this guidance
document. As required by FIFRA sec. 3(c)(2)(B), you are
required to take appropriate steps to comply with this Notice.
EPA may suspend the registration of each of those products
unless, within the specified time, you have informed EPA how
you will satisfy the requirements of this Notice. Any such
suspension will remain in effect until you have complied with
the terms of this Notice.
B. What Generic Data 1 ! Must be Submitted . You may deter-
mine which generic data you must submit by consulting Table A
at the end of this chapter. That table lists the generic
data needed to evaluate the continued registrability of all
products, and the dates by which the data must be submitted.
The required studies must be conducted in accordance with
EPA approved protocols (such as those contained in the Pesticide
Assessment Guidelines 2/ or data collected under the approved
protocols of the Organization for Economic Cooperation and
Development (OECD). If you wish not to develop data which
are necessary to support the reregistration of certain uses
appearing in your labeling, you may delete those uses at the
time you submit your revised labeling.
Also for certain kinds of testing (generally ecological
effects), EPA requires the test substance to be a “typical
11 Generic data pertain to the properties or effects of a
particular ingredient, and thus are relevant to an evaluation of
the risks of all products containing that ingredient (or all such
products having a certain use pattern), regardless of any such
product’s unique composition or use. Product—specific data relate
only to the properties or effects of a product with a particular
composition (or a group of products with closely similar composition).
2/ The Pesticide Assessment Guidelines are available in hard
copy or microfiche from the National Technical Information
Service, 5285 Port Royal Road, Springfield, Va. 22161.
40
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formulation,” and in those cases EPA needs data of that type
for each major formulation category (e.g., emulsifiable concen-
trates, wettable powders, granulars, etc.) These are classified
as generic data and when needed are specified in Table A.
EPA may possess data on certain “typical formulations” but
not others. Note : The “typical formulation” data should
not be confused with product—specific data (Table B) which are
required on each formulation. Product—specific data are
further explained in Chapter III of this document.
C. Options Available for Complying With Requirements
to Submit Data
Within 90 days of your receipt of this Notice you must
submit to EPA a completed copy of the form entitled “FIFRA
Section 3(c)(2)(B) Summary Sheet” (EPA Form 8580—1, Appendix
11—31 for each of your products. On that form you must state
which of the following methods you will use to comply with
the requirements of this Notice:
1. (a) Notify EPA that you will submit the data, and
(b) either submit the existing data you believe will
satisfy the requirement, or state that you will generate
the data by conducting testing. If the test procedures
you will use deviate from (or are not specified in) the
pesticide Assessment Guidelines or protocols contained in
the Reports of Expert Groups to the Chemicals Group,
Organization for Economic Cooperation and Development
(OECD) Chemicals Testing Programme, you must enclose the
protocols you will use.
OR
2. Notify EPA that you have entered into an agreement
with one or more other registrants to jointly develop (or
share in the cost of developing) the data. If you elect
this option, you must notify EPA which registrant(s) are
parties to the agreement.
3. File with EPA a completed “Certification of Attempt to
Enter Into an Agreement With Other Registrants for Develop-
ment of Data” (EPA Form 8580—6, Appendix II_4)*/
OR
/ FIFRA sec. 3(c)(2)(B) authorizes joint development of
data by two or more registrants, and provides a mechanism by
which parties can obtain an arbitrator’s decision if they agree
to jointly develop data but fail to agree on all the terms of
the agreement. The statute does not compel any registrant to
agree to develop data jointly.
(Footnote continued on next page)
41
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4. Request that EPA amend your registration by deleting
the uses for which the data are needed. (This option is
not available to applicants for new products.)
OR
5. Request voluntary cancellation of the registration(s)
of your products for which the data are needed. (This option
is not available to applicants for new products.)
D. Procedures for Requesting Changes in Testing Methodology
and Extensions of Time
EPA recognizes that you may disagree with our conclusions
regarding the appropriate ways to develop the required data
or how quickly the data must be submitted. If the test
procedures you plan to use deviate from (or are not specified
in) the registration guidelines or protocols contained in
the reports of the Expert Groups to the Chemical Groups,
Organization for Economic Cooperation and Development (OECD)
Chemicals Testing Programme, you must submit the protocol
for Agency review prior to the initiation of the test.
If you think that you will need more time to generate the
required data than is allowed by EPA’s schedule, you may
submit a request for an extension of time. Th& extension
request must be submitted in writing to the Product Manager.
The extension request should state the reasons why you conclude
that an extension is appropriate. While EPA considers your
request, you must strive to meet the deadline for submitting
the required data.
(Footnote continued from previous page)
In EPA’s opinion, joint data development by all registrants
who are subject to the requirements to submit a pertinent item
of data or a cost—sharing agreement among all such registrants
is clearly in the public interest. Duplication of testing could
increase costs, tie up testing facilities, and subject an unneces-
sarily large number of animals to testing.
As noted earlier, EPA has discretion not to suspend the
registration of a product when a registrant fails to submit data
required under FIFRA Section 3(c)(2)(B). EPA has concluded that
it is appropriate to exercise its discretion not to suspend in
ways which will discourage duplicative testing. Accordingly, if
(1) a registrant has informed us of his intent to develop and
submit data required by this Notice; and (2) a second regis-
trant informs EPA that it has made a bona fide offer to the
first registrant to share in the expenses of the testing [ on
terms to be agreed upon or determined by arbitration under FIFRA
Section 3(c)(2)(B)(iij)]; and (3) the first registrant has declined
to agree toenter into a cost—sharing agreement, EPA will not
suspend the second firm’s registration.
42
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III. REQUIREMENT FOR SUBMISSION OF PRODUCT—SPECIFIC DATA
A necessary first step in determining which statements
must appear on your product’s label is the completion and
submission to EPA of product—specific data* listed on the
form entitled “Product Specific Data Report” (EPA Form
8580—4, Appendix 111—1) to fill “gaps identified by EPA
concerning your product. Under the authority of FIFRA Sec.
3(c)(2)(B), EPA has determined that you must submit these
data to EPA in order to reregister your product(s). All of
these data must be submitted not later than six months after
you receive this guidance document.
“Product—Specific Data Requirements for Manufacturing
Use Products” appearing in Table B permit you to determine
which product—specific data you must submit. This can be
done by examining the entries in the column of those tables
entitled “Must Data By Submitted Under §3(c)(2)(B).”
/ Product specific data pertain to data that support the
formulation which is marketed; it usually includes product
chemistry data and acute toxicity data.
43
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TABLE A
GENERIC DATA RE OIREME ’IS R)R DISULFtY1DN
Test
Substance 1 !
Guidelines
Status 2 !
Are Data
Required 3 !
Footnote
Nunber
Data Requirement
§158.120 — Product Chemistn
Product Identity :
61—1 — Identity of Ingredients
61—2 — Statement of Ccxnpositjon
1 AI R E ]
R [ ] [ 1
61—3 — Discussion of Formation of R [ J [ J
Ingredients
Analysis and Certification of Product
Ingredients
62—1 — Preliminary Analysis ¶flAI R [ J [ ]
62—2 — Certification of Limits i Ai R [ X] fl
62—3 — Analytical Methods for It A1 R (XI I)
Enforcement of Limits
Physical and Chemical Characteristics
63-2 - Color AI R [ J F]
63—3 — Physical State ICAI R [ X l [ ]
63—4 — Odor ltAI R [ XI [ ]
63-5 — Melting Point R [ =1 [ I 4!
d 1
-------
TGAI R ( ] [ =1
1 GM R [ ] [ =1
1 GAI0rPAI R [ ] [ :1
PA l R [ ] [ =1
PAl R [ ] C)
PAl R E )
1GM R I
P3A1 R EXI CI
1GM R [ =1
Choice C i E I
TABLE A
GENERIC DATA REX UIREMEN1’S FGR DISULEUPON
Test
SubstanceV
Guidelines
Status 2 /
Are Data
Required 3 ’
Yes No
Footnote
Number
Data Requir 1leflt
§158.120 — Product Chemistry (con’t)
Physical and Chemical Characteristics
(Continued)
63—6 — Boiling Point
63—7 — Density, Bulk Density, or
Specific Gravity
63—8 — Solubility
63—9 — Vapor Pressure
63—10 — Dissociation constant
63—11 — Octanol/water partition
coefficient
63—12 — pH
63—13 — Stability
63—20 — Corrosion Characteristics
Other Requirements :
64—1 — Suth ittal of samples
CR
45
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TT BLE A
GENERIC DPiTA RFX (JIREMENTS FOR DISULFtIflJN
§158.120 — Product Chenistry (continued)
DPJTA REX UIRENEm F’CXYTh GrES:
1/ Test Substance: IT AI= Technical grade of the active ingredient; PAI= Pure active Ingredient;
Choice= choice of several test substances determined on a case—by—case basis.
2/ Guideline Status: R= Required; CR Conditionally required
3/ Data must be subuitted by _____________________
4/ Not required because the 95% technical is a liquid at roars tenperature
46
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TABLE A
G ERIC DPATA RE UIREME 1’S FOR DISULFU ON
Does EPA Have Data
Must Additional
To Satisfy This
Data Be Sutinitted
Requirement? (Yes,
Data Requirement CclTlposition 1 / No, or Partially)
Bibliographic
Citation
Under FIFRA Section
3(c)(2)(B)? 2 /
§158.125 Residue Chemistry
171—4 — Nature of Residue (Metabolism)
— Plants PAIRA Partially GSO1O20 0 1* Yes 3 !
GS0102002*
GS0102003*
GS0102004*
GS0 102005*
00032409*
00096498*
— Livestock PAIRA and plant Partially GSO1O2001* Yes 4 ’ 5 !
rnetabol ites GS0102006*a/
171—4 — Residue Analytical Method
— Plant residues I AI and metabolites Partially GS0102003* Yes 6 !
GS0102004*
GSO 102013*
GS0102007*
GSO1 O2 008*
GS0 102009*
GSO 102010*
CS O 1O2 O11*b/
GSO1O 2012* b/
GS0102014*
00071243*
00071237*
47
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TABLE A
GENERIC DATA REX )UIREMENfS FOR DISULFOTON
Does EPA Have Data
Must Additional
To Satisfy This
Data Be Sutinitted
Requirenent? (Yes,
Data Require ent Cmpositionl-/ No, or Partially)
Bibliographic
Citation
Under FIFRA Section
3(c)(2)(B)? 2 /
§158.125 Residue Chenistry
(continued)
171—4 — Residue Analytical Method (continued)
— Plant residues (continued) 00071233*
0004 1055*
00032409*
00028780*a/
— Animal residues ICAI and inetabolites Partially GS0102006*W Yes 6 ’
GS0102007*
GS01020 14*
00071245*
171—4 — Storage Stability Data PAl Yes GS0102002* No
GS0102015*
GS0102006*8/
GSO1O2O l2*a/
171—4 — Magnitude of the Residue—
Residue Studies for Each
Food Use
- I ot and Tuber Vegetable Group 10/
Potatoes Partially GS0102016* Yes 7 !
0009550]*a/
Sugarbeets TEP Partially GS0102004* Yes 8 !
GS0102032*
48
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TABLE A
GE ERIC DATA REX UIREMENTS FOR DISULFU1T
Does EPA Have Data
To Satisfy This
Requir eflt? (Yes,
No or partially)
GS0102004* No
GS0102032
Must Additional
Data Be Sutinitted
Bibliographic
Canposition 1 / Citation
Under FIFRA Section
3(c)(2)(B)? 2 /
Data RequirEnent
§158.125 Residue Ch nistry
(continued)
171—4 — Magnitude of the Residue —
Residue Studies (continued)
— Leaves of I ot and Thber
Vegetable Group ‘ /
Sugarbeets
Gs0l02 031*a/
TEP Yes
-
Leafy vegetable
Group 11 /
TEP
Partially
GS0102015
Yes 12 !
Lettuce
Spinach
TEP
Partially
GS0 102017
Yes’ 3 !
—
Brassica (cole)
Leafy
Vegetable
Gronp 14 !
Partially
GS0 102002*
GSO 10 20 18*
yes 15! 16 /
Broccoli
TEP
Brussel Sprc its
TEP
Partially
GS0 102015
Yes’ 5 !’ 7 !
Cabbage
TEP
Partially
GS0102002
yes l5/l 8 /
Cauliflower
TEP
Partially
GS0102015
yesl5/l 9 /
49
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TABLE A
GENERIC DATA RE UIRE24EWI’S FOR DISULF(YI
Does EPA Have Data
Must Additional
To Satisfy This
Data Be Sutinitted
Requiranent? (Yes,
Data RequirGnent Cclnposition 1 / No or Partially)
Bibliographic
Citation
Under FIFRA Section
3(c)(2)(B)? 2 /
§158.125 Residue Ch nistry
(cant i nued)
- Legume Vegetables
( succulent or dried) Group 20/
Dried Beans TEP Yes GS0 10203 1*a/ No
GS0 1020 15*
Lima Beans TEP Yes GS0102031*a/ No
GS O 10 20 15*
Peas TEP Yes GS0102031*W No
GSO 102015*
Snap beans TEP Yes GS0102031*W No
GSO1O2O1 5*
Soybeans TEP Partially GS0102019* Yes 21 !
GSO1O2 O11*
- Fol iage of Legume Vegetable Group 22 !
Bean Vines and Hay TEP Partially GS0102031*W Yes 23 !
GSO 102015*
Pea Vines and Hay TEP Partially GS0102031*a/ Yes 24 !
GSO 102015*
50
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TABLE A
GENERIC DATA RB(JIR 4ENTS FOR DISULFUIT
Does EPA Have Data
Must Additional
To Satisfy This
Data Be Sutxnitted
Requirei ent? (Yes,
Data Require ent Canposition’/ No or Partially)
Bibliographic
Citation
Under FIFRA Section
3(c)(2)(B)? 2 /
§158.125 Residue Chenistry
(continued)
Soybean Forage and Hay TEP Partially GSO1O2O11*b/ Yes 25
GS0102019*
- Fruiting Vegetables Group
Peppers TEP Partially GSO]02020b/ yes 26
Tonatoes TEP Partially GS0102031*W y es 27 /2 8
GS0102015* 29/
— Thee Nut Group 30 !
Pecans TEP Yes GS0 102012*b/
GS0102021*
— Cereal Grains Group
Barley TEP Partially GS0102031*W Yes 32 !
GS0102015*
Corn TEP Partially GSO102O31* / Yes 33 !
GS0102009*
GSO1O2O1O*
GSO1 O2O11*b/
CS0102022*
51
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TABLE A
GENERIC DATA REX (JIREMENIS FOR DISULF YION
Does EPA Have Data
Must Additional
I Satisfy This
Data Be Sutinitted
Requir nent? (Yes,
Data Requir nent Canpcsition 1 / No or Partially)
Bibliographic
Citation
Under FIFRA Section
3(c)(2)(B)? 2 /
§158.125 Residue Ch nistry (continued)
Oats TEP Partially GS0102015* Yes 32 !
GS0102 031*a/
Rice TEl ’ Partially GS0102018 Yes 34 !
Sorghum TEP Partially GS0102023* yes 32 ! 33 / 3 5/
GS0102009* 36!
GSO 10 203 1* a!
00095554*
00095502*
Wheat TEP Partially GS0102024* yes 32 ! 3 7/
GS0102031*W
GSO 10 2002*
— Forage, Fodder, and Straw
of Cereal Grain Group
Barley, Green Fodder 38 ! TEP Partially (3 50102015* Yes 39 !
Straw GS0102031*W
Corn, Fodder TEP Partially GS0102022* Yes 4 °
Forage GSO1O2O1 1*b/
GSO1O2 O1O*
GS0102009*
G 50102031*a/
Oat, Green Fodder 4 l/ TEP Partially Gs0102015* Yes 42 /
Straw GS0102031*a!
52
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TABLE A
GENERIC DATA RD (JIREMEN S FDR DISUUtYJX)N
Does EPA Have Data
Must Additional
‘lb Satisfy This
Data Be Sulnitted
Requir ent? (Yes,
Data Requiranent Canpositicn’/ No or Partially)
Bibliographic
Citation
Under FIFRA Section
3(c)(2)(B)? 2 /
§158.125 Residue Ch nistry (continued)
Rice, Straw TEP Yes GS0102018 No
Sorghim , Fodder 40 ! TEP Partially GS0102023* Yes 43 !
Forage GS0102009*
GSO 102031 * a/
00095502* a/
00095554*
Wheat, Green Fodder 41 ! TEP Partially GS0102002* Yes 44 !
Straw GS0102024*
GsO].02 031*a!
— Non—Grass Animal Feeds
( Forage, Fodder, Straw,
and Hay) Group ’ /
Alfalfa TEP Partially GS0102002* Yes 46 !
Alfalfa, hay GS0102031*W
00095502* a!
Clover TEP Pai±ially GS0102025 NO 46 ’
Clover, hay
Asparagus TEP Partially GSO1O2O13 Yes 47 !
Coffee Beans TEP Partially GS01020l0* Yes 48 !
GSO 102008*
Cotton, forage TEP Partially GS0102003* Yes 49 !
Cottonseed 00095622*
53
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Hops
Peanuts 50 !
Peanuts, hulls
Peanuts, hay
Pineapple
Pineapple foliage
sugarcane 53 /
Tbbacco
TABLE A
GENERIC DATA RF UIREM ’IS FOR DISULRYrON
Does EPA Have Data
To Satisfy This
Requir ent? (Yes,
No or Partially)
Data Requir ent
§158.125 Residue Chfflnistry (continued)
Must Additional
Data Be Sutinitted
Bibliographic
Canpositioni! Citation
Under FIFRA Section
3(c)(2)(B)? 2 !
- Crops Gr n Solely for Seed
Carrots
Garlic
Onions
Radishes
Dirnips
TEP
Yes
GS0102026b/
No
TEP
Partially
GS0102018*
GS O 1020
GS 0102 03]*a/
Yes 51 !
TEP
Partially
GS0102018
Yes 52 !
TEP
Partially
GS O1O2O1O
Yes 54 /
TEP
Partially
00002477*
00095498*
Yes 55 !
TEP
No
—
yes 56 !
TEP
No
—
Yes 56 !
TEP
No
—
yes 56 ’
TEP
No
—
yes 56 !
TEP
No
yes S 6 !
54
-------
TABLE A
GF ERIC DP TA REX JIREMFWI’S FOR DISULFOTON
Does EPA Have Data
Must A ditiona1
To Satisfy This
Data Be Subnitted
Section
Requir ent? (Yes,
Data Requir nent Cciripositio&J No or partially)
Bibliographic
Citation
Under FIFRA
3(c)(2)(B)? 2 /
§158.125 Residue Ch istry (continued)
171—4 — Magnitude of the Residues
in Food—Producing Animals
Meat/Milk/Poultry/Eggs i 3A1 or Partially 0S0102025* Yes 57 !
plant metabolites GS0102006*
0102026 *b/
GS0102027* a!
GSO1O 2030* aJ
-— Post Processing Residue TGAI or No Reserved 58 !
Studies plant metabolites
55
-------
TABLE A
GE 4ERIC EATA RE (JIRE21ENTS FOR DISULFtTION
§158.125 Residue Ch nistry (continued)
1/ Ccrnposition= ‘IGAI= Technical grade of the active ingredient; PAIRA= Pure active ingredient, radiolabeled;
TEP= Typical end—use product
DEC t986
2/ Data must be subnitted no later than ________________________
3/ Data delineating the quantification of each oxidative metalxlite present in samples of crcps representing
each crcp grouping must be sutrnltted.
4/ Data delineating the quantification of oxidative metabolites present in meat, milk, poultry, and eggs must
be sutmitted.
5/ a. Metaboli n studies utilizing ruminants must be subuitted. Animals must be dosed with [ 14 C] disulfoton at
12 p n in the diet for 3 days. Milk must be sampled twice daily throughout the dosing period. Animals
must be sacrificed within 24 hours of the final dose and residues characterized and quantified in milk,
muscle, fat, kidney, and liver. The dose should include the following metabolites in a 1:5:2:10 ratio:
disulfoton sulfoxide (II), disulfoton sulfone (III), disulfoton oxygen analog sulfoxide (V), and disulfoton
oxygen analog sulfoxide (V), and disulfoton oxygen analog sulfone (VI). The ratio is based on plant metabol i i
studies. The animals should be sacrificed within 24 hours of the last dose. If ruminant metabolism is found
to differ significantly fran that of rats (based on previously—subnitted rat metabolism studies), then non—
ruminant (swine data) will be required.
b. Metabolism studies utilizing poultry must be suttnitted. Animals must be dosed with E 14 C] disulfoton at
2.0 ppn in the diet for 3 days. Eggs must be sampled twice daily throughout the dosing period. Animals
must be sacrificed within 24 hours of the final dose and residues characterized and quanitified in eggs,
muscle, fat, gizzard, heart, liver and skin. The dose should include the same metabolites as those depicted
for the ruminant study.
6/ A method must be provided which can be used without an oxidation step for the purpose of identifying
and quantifying individual metabolites.
7/ Additional residue data must be sutinitted which reflects a single at—planting soil application (ground
or aerial) followed by a single post ergent broadcast aerial application of a 15% G at 3 lb. a.i./A
56
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TABLE A
GE1 ERIC DATA REXJ(JIREMENTS FOR DISULFUION
§158.125 Residue Ch nistry (continued)
rate. Residues must be determined 75 days after the second treatment. Tests must be conducted in
Oregon and Washington.
8/ Data on residues in dehydrated sugar beet pulp, molasses, and refined sugar due to the processing of sugar beets
having weathered, measurable residues must be sutmitted.
9/ A group tolerance is not appropriate at the present time because residue data are required for one additional
m nber of this group (turnip leaves).
10/ A group tolerance is not appropriate at the present time because residue data are required for t additional rn bers
of this group (carrots and radishes).
11/ A group tolerance is not appropriate at the present time because residue data are required for one additional m ttber
of this group (celery).
12/ Additional data must be sutinitted reflecting residues in leaf and head lettuce (with and without wrapper leaves)
gr n in Arizona and California (including irrigated regions) a) 60 days after an at—plant banded soil application
(spring—or sinwner-seeded) of a G or EC formulation at 1.2 oz. a.i./l000 feet of r ’i (2.18 lb a.i./A with an 18 inch
r spacing), and b) 60 days after a post—Energerit banded soil application (fall—or winter-seeded) as a side-dress at
thinning with one G and one EC formulation at 1.2 oz a.i,/1000 rc feet (2.18 lb a.i./A with an 18—inch rc spacing.)
13/ Additional data must be sutnitted reflecting residues in or on spinach gr in in California (including irrigated
regions) 42—50 days (normal harvest) after an at—plant banded soil application of a G or EC formulation at 0.6
oz a.i./l000 feet of r .
14/ A group tolerance is not appropriate at the present time because residue data are required for one additional
member of this group (mustard greens).
15/ Additional residue data must be subnitted using either a G or an EC formulation as a postemergence broadcast
soil application at 0.92 oz. a.i./2500 square feet in the transplant bed foll ed by a single sidedress application
(broccoli) at 1.125 oz. a.i./1000 feet of rc i to established plants in the field. For brussel sprouts, cabbage,
and caulif1 er, two sidedressings are necessary at above rate.
57
-------
TABLE A
GE JERtC DATA REX UIREMEN1’S FOR DI JLRYI ON
§158.125 Residue Ch nistry (continued)
16/ Samples should be harvested 14 days after the sidedress treatment.. Tests should be conducted In California
(including irrigated regions).
17/ Samples should be harvested 30 days after the last sidedress treatment. Tests should be conducted in California
(including irrigated regions).
18/ Samples should be harvested 42 days after the last sidedress treatment. Test should be conducted in California
(11%), Florida (21%), New York (14%) and Texas (22%) (including irrigated regions); the percentages given for
each state represent the contribution of each state to the total U.S. cabbage crop.
19/ Samples should be harvested 40 days after the last sidedress treatment. Tests should be conducted in California
(including irrigated regions).
20/ A group tolerance is not apprcpriate at the present time because a) the established tolerances in or on dry beans,
lime beans, snap beans, and peas are more than 5X greater than the established tolerance for soybeans; and b)
the ca modity definitions for linta beans as stated in 40 CFR 180.1 (J)(8) (beans and the pod) arid for snap beans
differ significantly fran those for dry beans, peas, and soybeans.
21/ Residue data on soybean hulls, soapstock, and refined oil processed fran soybeans having measurable weathered
residues must be sutmitted. It may be necessary to use exaggerated rates to achieve measurable residues in the
raw agricultural ca iiiodity. Should residues be found to concentrate in any of these processed products, appropriate
food/feed additive tolerances must be prcposed.
22/ A group tolerance is not appropriate at the present time because the established tolerance for bean and pea vines
are more than SX greater than the established tolerance for soybean forage.
23/ Additional residue data must be suth itted for bean vine hay harvested 60 days after a single post nergent soil
application (double banded sidedress on each side of row after plants are established) of a registered G or EC
formulation at 1.9 oz a.i. (1000 feet of row). Tests must be conducted in California, Michigan, New York, and
Oregon (major U.S. growing regions for dry, snap, and lime beans). Alternatively, a label restriction may be
proposed which would prohibit feeding of bean vine hay to livestock.
24/ Additional residue data must be sutuiitted for pea vine hay harvested 50 days after a simple post ergent soil
application (banded sidedress after plants are established) of a registered C or EC formulation at 2.5 lb/A.
58
-------
ThBLE A
GENERIC DATA REQUIRF2IENTS FOR DISULFUIt)N
§158.125 Residue Chemistry (continued)
Tests must be conducted in Washington and Wisonsin since these states represent the majority of crop production
area for green peas for processing. Alternatively, a label restriction may be proposed which would prohibit
feeding of pea vine hay to livestock.
25/ Additional residue data are required for soybean hay harvested 75 to 125 days (depending on the prefeeding
restriction proposed) after an atplanting application of one of the registered G formulations at 1.2 oz
a.i ./l000 feet of row. Tests must be conducted in Illinois, Minnesota, and Missouri since these states
represent the major U.S. soybean production areas. Available data do indicate one of the following should
be proposed for soybean forage a) a tolerance increase and a 75—day pregrazing and prefeeding restriction,
or b) a 125—day pregrazirig and prefeeding restriction. Should the registrant wish to propose a tolerance
increase, we recamnend a level of 2ppe , which would make the soybean forage and bean and vine tolerances
ccmpatible.
26/ While the existing tolerance on peppers is based on adequate residue data, this data was generated for a
soil application. However, since there are no data available to support the state labels calling for foliar (EC)
applications, residue data must be sutznitted fran peppers harvested at intervals appropriate to the state labels
after foliar treatment with an EC formulation at the maximum registered rate. The studies should take place in
California.
27/ Additional residue data are required for tcinatoes obtained fran plants 30 days after the second of two postemergent
soil applications, spaced 21 days apart, of the 61b./gal/ EC and, in a separate test, a representative G formulation
at 2.4 oz a.l./1000 feet of row. The plants used in the above trial should be grown in transplant beds that were
treated postemergence at 2.75 oz a.i./2500 square feet with a representative G formulation. The field studies
should take place in California.
28/ Additional residue data are required for tanatoes obtained 30 days after a single, postenergence soil application
of the 6 lb/gal. EC and (in a separate test) a representative G formulation at 11 oz a.i./l000 feet of row (72—inch
row spacing). The plants used in the above trial should be raised in transplant beds treated postenergent at 2.75 oz
a.i./2500 square feet with a representative G formulation. The field studies should take place in an alkaline soil
in Florida.
29/ Residue data must be suthiitted for puree, catsup juice, wet and dry panace obtained by pra essing tcznatoes having
weathered residues at or above the tolerance. This may require that the tcmatces be treated at exaggerated rates.
59
-------
TABLE A
GENERIC DATA RE UIREMENIS FOR DISULRYI )N
§158.125 Residue Chemistry (continued)
30/ A group tolerance is not apprcpriate at the present time because residue data are required for two additional members
of this group (almond and English walnut).
31/ No additional data are required; however the existing tolerance should be decreased fran 0.75 p n to 0.1 pp in order
to correspond with expected residues at the highest label rate (3 lb a.i./A)(EC); and also to achieve canpatibility
with Codex MRL.
32/ Residue data are required fran the milled products of wheat grain, obtained by processing wheat grain samples
containing measurable weathered residues. This may require that wheat samples be treated at exaggerated rates. This
data will be translated to barley, oats, and sorghum to totally or partially fulfill the same requirements for these
catinod it i es.
33/ Residue data are required fran representative processed products of field corn, including crude oil, refined oil,
and milled products, and sweet corn (cannery waste) after processing corn bearing measurable weathered residues.
This may require that corn samples be treated at exaggerated rates. This data will be translated to sorghum to
partially fulfill the same requirement for this ccmnodity.
34/ Residue data are required f ran rice and its milling products, including polished rice, hulls, and other milled
products, obtained fran rice bearing measurable weathered residues. This may require that rice be treated at
exaggerated rates.
35/ Residue data are required f ran sorghum grain harvested 7 days after the second of two foliar applications, spaced
three days apart, at 1 lb. a.i./A. Separate tests of aerial and ground applications should be done in Texas and
Oklahcrna.
36/ Additionally, infotmation must be suth itted to indicate the rate of application in oz a.i./l000 feet of row for
all soil treatments. Current label rates given as 1 lb. a.i./A may correspond to as low as 0.43 oz a.i./1000
feet of row, if a narrow (14—inch) row spacing was used, and thus the maximum or near maximum rate would not
be represented by much of the data currently in the Agency files.
37/ Residue data are required fran winter wheat grain harvested 30 days after the last of the following treatments:
an at—planting, fall application of the 15% G at 1 lb a.i./A followed by two foliar treatments with the 6 lb.!
gal. EC at 0.75 lb. a.i./A at 30 day intervals in the fall, followed in the spring by two identical follar
60
-------
TABLE A
GENERIC DATA RE) UIREMENI’S FOR DISULFUIt)N
§158.125 Residue Chemistry (continued)
treatments starting 90 days before expected harvest. The studies should be done in Texas, Nebraska, California,
Montana, Tennessee, and New York which represent the major winter wheat production areas, as well as the various
climatic regions of the U.S. Foliar treatments must be applied in separate tests using aerial and ground equip-
ment.
38/ A tolerance for barley hay must be proposed, based upon the data requested in 39/• Also the ccmnodity definition
“green fodder” should be changed to “forage”.
39/ Additional residue data must be sutznitted fran barley forage and hay cut 30 days after the second treatment of
each of the foll ing two treatment regimes: a) a pre—ernergence soil application and a post—emergence foliar
application, following as soon as is normally practiced, of the 6 lb./gal EC at 1 lb. a.i./A; b) two ground—
applied, foliar treatments spaced at a practical interval, of the 6 lb./gal EC at 1 lb. a.i./A. In addition
residue data fran straw cut 60 days after the former treatment regime (a) should be sut xnitted. The studies
should be conducted in California, Montana, North Dakota, and Washington.
40/ Additional residue data must be sut nitted and tolerances proposed for both corn and sorghum silage. Such data
should be derived for corn silage produced by ensiling corn forage bearing weathered residues at or near the
5 ppn tolerance. Exaggerated rates or early harvesting may be required to obtain such forage. If not concen-
tration of residues takes place, the corn silage tolerances should be proposed at 5 p n; if concentration does
occur, an appropriately higher tolerance should be recaim ended. These data will also be used to propose a
tolerance for disulfoton residues in or on sorghun silage.
41/ The cx inodity definition “green fodder” should be changed to “forage”.
42/ A tolerance must be proposed for oat hay based upon data requested for wheat hay in 44/•
43/ Additional residue data must be subnitted for sorghum fodder subject to an at—plant application with a G formulation
at 1.2 oz a.i./1000 row feet followed by a postenergence sidedress treatment with an EC at 0.5 lb. a.i./A followed
by a postemergence sidedress treatment with an EC at 0.5 lb a.i./A followed by three aerially-applied foliar
treatments with an EC at 1 lb a.i./A. Fodder should be prepared for sampling 34 days after the final treatment.
Studies must be conducted in Okiahana and Texas. Residue data must also be subnitted fran sorghum fodder and forage
harvested 28 days after the second of two foliar applications of an EC, spaced 3 days apart, at 0.5 lb. a.i./A.
Tests should take place in Texas.
61
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TABLE A
GENERIC DATA RE JIREMENIS FOR DISULE’OTON
§158.125 Residue Ch nistry (continued)
44/ Additional residue data must be sutxnitted and tolerances proposed for both oat and wheat hay. Such data should
be derived fran wheat forage, hay, and straw taken 30 days after the last of the following treatments: an at—
planting, fall application with a G formulation at 1 lb. a.i./A, a broadcast application of the 0.75% G at 0.75 lb.
a.i./A made when the crop is established, followed by two foliar treatments with the 6 lb/gal. EC at 0.75 lb a.i./A
at 30 day intervals, followed in the spring by two identical foliar treatments starting 90 days before expected
harvest. Foliar applications should be made with aerial and ground equi ment and should take place in Texas,
Nebraska, California, Montana, and Tennessee, which represent the major wheat producing areas registered as use
sites.
45/ A group tolerance is not appropriate at the present time because a 7—day preharvest interval (PHI) has been
established for clover, whereas no PHI exists for alfalfa. Since both crops are caiinonly planted in mixtures,
the disparity between PHI’s is unrealistic and must be resolved.
46/ Additional data are required which reflect residues in or on alfalfa (fresh) and alfalfa hay samples collected at 0,
7, and 14 days after the last of four broadcast applications (one at—planting and three prior to growth fran
established stubble) made during one growing season. Tests should reflect use of the 15% G or the 6 lb./gal. EC
formulation at 1 lb a. i ./A application in California (8%), Nebraska (6%) and Wisconsin (11%); the percent
contribution to annual U.S. alfalfa production is given in parenthesis. Additional data are also being required
which reflects residues in or on alfalfa hay and seed harvested 14 days after the last of four aerial and ground
foliar applications with the 6 or 8 lb./gal. EC formulation at 1 lb. a.i./A. Tests should be conducted at the
sites detailed above. Upon subnission of data pertaining to alfalfa seed, a tolerance for disulfoton residues
in or on alfalfa seed must be proposed, if necessary. Finally, a processing study Is required to determine
residues in meal processed f ran field—treated hay containing detectable, weathered residues; if residues are
found to concentrate in meal, a feed additive tolerance must be proposed. The above data on alfalfa will be
translated to clover.
Note: Until the above data is su nitted a grazing restriction must be placed on the appropriate product labels for
alfalfa hay, in addition to the existing restriction against feeding and foraging of cut green alfalfa grown
for seed production.
47/ Additional residue data must be sulinitted for asparagus (fresh spears) harvested 4 months after the last of
three foliar applications made at greater than 14-day intervals with the 8 lb./gal. EC formulation at 1 lb. a.i./A
in the states of California and Washington. Applications must be made using ground and aerial equiçment.
62
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TABLE A
GENERIC DATA REI )UIREMENIS FOR DISULFCIION
§158.125 Residue Ch nistry (continued)
48/ Additional residue data must be sutmitted for coffee beans bearing measurable weathered residues; it may be necessaiy
to use exaggerated application rates to obtain detectable residues in the green coffee beans. If residues are found
to concentrate in instant coffee, a food additive tolerance must be proposed.
49/ Additional residue data must be subnitted for cottonseed and forage after the following consecutive treatments:
(a) seed treatment with the 9.14 lb./gal. WIli formulation at 8 Oz. a.i./lOO lb of seed; (b) a preplant banded
soil application of a registered EC formulation at 1.2 oz a.i./l,000 feet of row; (c) an at—plant band soil
application of a registered G and EC formulation at 1.0 oz a.i./l,000 feet of row; and (d) two postenergent
soil applications (made 21 days apart) of a registered G and EC formulation at 1.2 and 2.4 oz a.i./1,000 feet of
row (G formulation at 2.4 02 rate on irrigated cotton only). Seed samples should be collected 28 days after the
last postenergent treatment at 1.2 oz. a. i./l ,000 feet of row and 90 days after the last postenergent treatment
at 2.4 oz./a.i./l,00 0 feet of row. Forage samples should be collected in Arizona, California, Mississippi, and
Texas which together account for 80% of U.S. cotton production.
Also data must be reflecting residues in or on cottonseed and forage after seed treatment with the 9.14 lb/gal. RIU
formulation at 8 oz. a.i./lOO lb. of seed followed by three foliar spray applications made prior to blocin of the
6 or 8 lb/gal. EC formulation at 9 oz...a.i./A, foliar application should be made using both aerial and ground
equi xnent. Cottonseed data are required only for aerially—applied treatments. Forage samples should be collected
at weekly intervals throughout the growing season. Tests should be conducted in the same states noted above.
Finally data must be sutmitted reflecting residues in meal, hulls, soapstock, and crude and refined oil processed
fran cottonseed bearing measurable weathered residues. If residues are found to concentrate in any of these
processed products, then appropriate food/feed additive tolerances must be proposed.
The above required data for cottonseed forage must be accaipanied by a tolerance proposal. Alternatively, grazing
and feeding restrictions may be proposed.
50/ A tolerance rnsut be proposed for peanut vines based upon data requested in 51/ below.
51/ Additional residue data must be subnitted for the .processed ccrm dlties peanut meal, crude oil, soapstock, and
refined oil. The processed caruiodities must be derived fran peanuts containing detectable, field weathered residues.
Additionally residue data must be sutrnitted for peanuts, peanut hulls, hay and vines reflecting one preplant, broad—
63
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TABLE A
G ERIC DATA RE JIREM ’IS FDR DISLJLFXY N
§158.125 Residue Ch nistry (continued)
cast, soil—incorporated application of 6—8 lb./gal. EC formulation at 6 lb. a.i./A follcMed by two soil applications
of a G or EC formulation, both early poste ergence and at—pegging at 2.25 oz. a.i./l000 feet of rc (at least 2 lb.
a.i./A).
52/ Additional residue data must be suhnitted in which residues are measured in or on pineapple forage (foliage) 60 days
after the last of two broadcast applications made during the same crop season with one of the G formulations at
2.5 lb. a.i./A; the final application must be applied by leaf base feeding. Tests should be conducted in Hawaii.
Also required is a determination of residues in juice and bran processed frcm disulfoton — treated pineapple, bearing
detectable, weathered residues.
53/ Since sugarcane forage is used for animal feed, appropriate residue data (noted below), a tolerance proposal, and
a pregrazing interval proposal are required; alternatively, a feeding and grazing restriction may be proposed.
54/ Also additional data must be subnitted reflecting residues in or on sugarcane and sugarcane forage following four
weekly foliar applications (both aerial— and ground—applied) of one of the registerd EC formulations at 9 oz. a.i./A.
Sugarcane should be harvested 28 days after the last treatment. Forage should be sampled throughout the treatment
period and at weekly interval thereafter up to 28 days. Tests should be conducted in Puerto Rico and Florida.
Finally data reflecting residues in or on nolasses, refined sugar, and bagasses processed fran sugarcane bearing
measurable weathered residues must be sut nitted. It may be necessary to use exaggerated application rates to
achieve detectable residues in the raw agricultural cai odity. If residues are found to concentrate in any of these
processed products, appropriate food/feed additive tolerance must be proposed.
55/ Additional data must be subnitted which reflects residues of disulfoton and its cholinesterase-inhibiting metabolites
in or on green freshly-harvested tobacco treated with a post nergent broadcast soil application (in the transplant
bed) of one the registered G formulations at 3.75 oz a.i./2,5000 square feet followed by a preplant incorporated soil
application (in the field) of one of the G formulations at 6 oz. a.i./l,000 feet of row and, in separate tests, one
of the registered EC formulations at 4 lb. a.i./A.
If residues of >0.1 ppn are detected in the green, freshly harvested tobacco, then pyrolysis products derived fran
disulfoton and its cholinesterase—inhibiting metabolites, and/or formulation impurities must be characterized and
quantified.
64
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TABLE A
GE 1ERIC DATA REX UIREMENIS FOR DISULF(YION
§158.125 Residue Ch istry (continued)
56/ At the time these uses were registered, residue data was not required. Presently these uses are considered as
feed uses, unless supportive residue data are available to indicate no detectable residues occur in the plants
as a result of the maximum registered use rate. Since such data is not presently available, it must be sutinitted.
If the data indicate residues do occur in these ccirvnodities, appropriate tolerances must be requested.
57/ The metaboli of disulfoton in animals is not adequately understood. Additional data is being requested (in 4/)
to identify and quantify metabolites. Should metabolites of concern differ fran those currently sought, additional
data will be required. The available data indicate the necessity of proposing tolerances for poultry at 0.01 ppn
and eggs at 0.001 p in (limits for sensitivity of available methods)
58/ The requirenent for these data will be reserved, pending receipt and evaluation of the appropriate residue studies
noted above.
*All references must be cited
a) Studies sul nitted by Ch nagro Ag. Div., Mobay Corp. These data may be canpensable.
b) Studies sut nitted by Chanagro Corp. These data may be ccmpensable.
65
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TABLE A
G ERIC DATA RFXXJIRF 4E TIS FOR DISULFtYflJN
Must Additional
Does EPA Have Data
Data Be Suth itted
Use
Canposition’/ Pattern 2 !
To Satisfy This
Requir nent? (Yes,
No or Partially
Bibliographic
Citation
Under FIFRA Section
(c)(2)(B)? 3 /
(See asterisks)
Data Requir ent
§158.130 Environmental Fate
D XRADATION SThDIES-LAB :
161—1 — Hydrolysis
Photodegradat ion
161—2 — In water
161—3 — On soil
161—4 — In Air
METABOLISM SIUDI ES—LAB :
162—1 — Aerobic Soil
162—2 — Anaerobic Soil
162—3 — Anaerobic Aquatic
162—4 — Aerobic Aquatic
MOBILITY SIUDIES :
163—1 — Leaching and
Adsorpt ion/Desorpt ion
1GM
or
PAIRA
A,B,C,F,G
No
—
Yes*
1T3AI
or
PAIRA
A,B,C,G
No
—
Yes*
IGAI
or
PAIRA
A,C
No
Yes*
IGAI
or
PAIRA
A
No
-
YeS***
1GM
or
PAIRA
A,B,G
No
Yes**
1GM
or
PAIRA
A
No
Yes**
1GAI
or
PAIRA
C,G
No
Yes**
TGAI
or
PAIRA
C
No
Yes***
IGAI
or
PAIRA
A,B,C,G
Partially
00068214W
Yes 4 !*
66
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TABLE A
GENERIC DATA REX)(JIREMENTS F DR DISULF(YI )N
Must Additional
Does EPA Have Data
Data Be Sutinitted
Use
Cartposition’/ Pattern 2 ’
To Satisfy This
Requirement? (Yes,
No or Partially
Bibliographic
Citation
Under FIFRA Section
(c)(2)(B)? 3 /
(See asterisks)
Data Requirement
§158.130 Environmental Fate
163—2 — Volatility (Lab)
163—3 — Volatility (Field)
DISSIPATION SIUDIES-FIELD :
164—1 — Soil
164—2 — Aquatic (Sediment)
164—3 — Forestry
164—4 — Ccinbinat ion and
Tank Mixes
164—5 — Soil, Long—tezm
ACCUMULATION SIUDI ES :
165—1 - Rotational Crops
(Confined)
165—2 — tational Crcps
(Field)
TEP
A,G
No
—
Yes***
TEP
A,G
No
—
Yes***
TEP
A,B
Partially 5 !
00068096 b/
Yes 6 /**
TEP
C
No
-
Yes***
TEP
G
No
—
Yes**
—
—
—
—
Yes***
TEP
A,C
No
—
Yes***
PAIRA
A,C
No
Yes***
TEP
No
Yes***
TEP
C
No
Yes***
165—3 — Irrigated Crops
67
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TABLE A
GENERIC DATA REX UIREMENTS FOR DISULF Y1 JN
Must Additional
Does EPA Have Data
Data Subnitted
Use
Data Require ent Canpositioni! Pattern 2 !
I Satisfy This
Require ent? (Yes,
No or Partially
Bibliographic
Citation
tinder FIFRA Section
(c)(2)(B)? 3 /
(See asterisks)
§158.130 Environmental Fate
(continued)
165—4 — In Fish 1 AI or PAIRA A,C No Yes
165—5 — In Aquatic Non—Target TEP C,G No Yes
Organi sns
1! Ccriposition: It AI = Technical grade of the active ingredient; PAIRA = Pure active Ingredient, radiolabelled;
TEP = Typical end—use product.
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; B=Terrestrial, Non—Food; C=Aquatic, Food Crop;
E Aguat Ic, Non—Food; E=Greenhouse, Non-Food; G=Forestry; H=Danest i c Outdoor; I=Indoor.
3/ Data must be sul:initted no later than *J e 1985, **Dac .J r 1986, 1987 .
4! Require one study of absorption/desorption on aquatic sediment, and n ,bi1ity data for disulfoton on sandy loam.
5/ Data identifies degradates sulfone and sulfoxide, but lacks information on decline of disulfoton and/or degradates.
6! Require test on representative dcmestic soil and at highest recamiended label rates.
a) Studies sitinitted by Mobay Ch ica1 Corporation. These data may be canpensable.
b) Studies sulxnitted by Id Pn erica, Inc. These data may be canpensable.
68
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Data Requir nent
§158.135 Toxicology
ACUTE TESTING :
81—1 — Oral — Rat
81—2 — Dermal
81—3 — Inhalation — Rat
81—7 - Acute Delayed
Neurotoxicity — Hen
SUBGll IC TESTING :
82—1 — 90—Day Feeding —
Rodent, Non-Rodent
82—2 — 21—Day Dermal
82—3 — 90—Day Dermal
TCAI
T AI
TCAI
AI
AI
AI
A,B,C,D,E
F,G,H
A,B,C,D,E,
F,G,H
A,B,C,D,E
F,G,H
A,B,C,D,E
F,G,H
A,C,E
A,E,F,G
A,E,F,G
Yes
Yes
No
No
GSO1O 2 300a/
Gso]. 02300a/
No
No
Yes*
Yes*
TABLE A
GENERIC DATA RD UIREMENIS FOR DISIJLF(Y1TJN
Does EPA Have Data
To Satisfy This
Requirenent? (Yes,
No or Partially
Must Additional
Data Be Sutrtitted
Under FIFRA Section
Use
Ccrnposition’/ Pattern 2 ’
Bibliographic
Citation
(c)(2)(B)? 3 /
(See asterisks)
No
No
No
Yes 4 /*
yesS/* *
No 6 !
69
-------
Data Requir ent
§158.135 Toxicology (continued)
SUBCHRJNIC TESTING (continued)
82—4 — 90—Day Inhalation —
Rat
82—5 — 90—Day Neurotoxicity-
Hen/Manv a1
CH} JNIC TESTING :
83-1 — Chronic Toxicity —
2 species: Rodent
and Non—rodent
83—2 — Oncogenicity Study —
2 species: Rat and
Mcuse preferred
83—3 — Teratogenicity —
2 species
83—4 — Reproduction,
2—generation
MUTN3ENICITY TESTING
84—2 — Gene Mutation
TABLE A
GENERIC DATA REX UIREMENTS DR DISOLFUJX)N
Must Additional
Does EPA Have Data
Data Be Sutinitted
Use
canposition 1 / Pattern 2 ’
To Satisfy This
Requir nent? (Yes,
No or Partially
Bibliographic
Citation
Under FIFRA Section
(c)(2)(B)? 3 /
(See asterisks)
A,E,F,G
No
Yes 7 /**
A,E,F,G
No
Yes 8 /**
GAI
AI
‘ItAI
A,C,E
Partially
0 0 07 33 48a/
Yes 9 /***
1 AI
A,C,E
Partially
GSO1O23O1W
Yes 9 /****
AI
A,B,C,E
F,G,H,I
Partially
GS0102302a/
YeslO/****
ICAI
A,B,C,D
E , F ,G
No
Yes****
1X AI
A,B,C,E
Partially
GS0102303
70
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TABLE A
GENERIC DATA RErUIRErVWrS R)R DISULFOION
Must Additional
Does EPA Have Data
Data Be Sutxnitted
Use
Ccznpositionl/ Pattern 2 !
To Satisfy This
Requirenent? (Yes,
No or Partially
.
Bibliographic
Citation
Under FIFRA Section
(c)(2)(B)? 3 /
(See asterisks)
Data Requir ient
§158.135 Toxicology (continued)
84—2 — Other Mechani ns of
Mutagenicity
SPECIAL TESTING
85—1 — General Metaboli n
85—2 — Danestic Animal Safety
— — Deiinal Absorption
— — Product Integrity
Studies
F,G,I
A,B,C,E,
F,G,I
MUTACENICITY TESTING (continued)
84-2 — Chranosanal Aberration
1 AI
A,B,C,E,
F,G,I
PAl or PAIRA A,C,F,I
Choice A,B
No
Partially 0 0 028625 b/
Partially 00083251
GSO 1 O 200 6a/
Yes 000134 R7C/
No
No
TEP
TEP
(Granular)
Yesl 2 /****
Yesl 3 /****
Yesl 4 /**
No
yesl5/*
Yesl 6 /*
A,B,G
A,B,C,D,
E,F,G,H,I
71
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TABLE A
G 4ERIC DATA REX (JIREME 4TS FX)R DISULFCY ON
§158.135 Itxicology (continued)
1/ Canposit ion: PAl = Pure active ingredient: PAIRA = Pure active ingredient, radiolabelled; Choice = Choice of
several test substances determined on a case—by--case basis.
2/ The use patterns are coded as follows: A=Terrestrial, Food Cr ; BTerrestrial, Non—Food; C—Aquatic, Food
Crop; E Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; Fl=Danestic Outdoor;
1= Indoor.
3/ Data must be sutrnitted no later than *J j 1985, ** j 1985, ***Janualy 1985, ****Dc . r 1987 .
4/ Using oxidation matabolites of disulfoton.
5/ Only if worker exposure analysis indicates potential hazard of repeated exposure.
6/ The 21 day dermal study would be sufficient to assess the possible dermal exposure associated with the current
pesticidal use of disulfoton.
7/ Only if worker exposure analysis indicates potential hazard of repeated exposure, and if product integrity studies
indicate that respirable dust is generated during shipping and handling (see data gaps).
8/ Contingent upon the outcane of the acute delayed neurotoxicity study.
9/ Testing required in the rat.
10/ Testing required in another species (other than the rat).
11/ In vitro manmalian cell; LS178 (1K), CHO (HGPWr), or v79 (HGPRT).
12/ Sister chranatid exchange in CHO cells or human lymphocytes and dcxninant lethal.
13/ Contingent upon the outcme of 7 and 8 above.
14/ An adequate study is required to delineate the pharinacokinetic and pharmacodynamic aspect. Preferred test organism
is the rat.
15/ In order to estimate toxicity which may result fran dermal exposure to the chemical or its major metabolites, an
estimate of the rate of dermal penetration of these moieties must be established. Dermal uptake kinetics and excretion
kinetics studies must be provided to estimate body dose at any point in time after exposure. Such studies are
necessary for the risk asses nent to those occupationally or accidentally exposed dermally.
16/ A prcposed protocol is to be subnitted and approved by the Agency prior to initiating these studies.
a) Studies su)xnitted by Mobay Chemical Corp. These data may be canpensable.
b) Studies sutinitted by FMC Corp. These data may be canpensable.
c) Studies subnitted by Chemagro Corp. These data may be canpensable.
72
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TABLE A
GENERIC DATA RF) (JIREMENTS FOR DISULEtII’ON
Data Requirenent
Ccinpositionh!
Use
Pattern 2 !
Does EPA Have Data
I D Satisfy This
Requir nent? (Yes,
No or Partially)
Bibliographic
Citation
Must Additional
Data Be Subnitted
Under FIFRA Section
3(c)(2)(B)? 3 /
§158.140 Reentry Protection
TEP
A,B,C,F,G
No
—
Yes 4 / 5 /
132—1 — Foliar Dissipation
132-1 — Soil Dissipation
TEP
A,B,C,F,G
No
—
Yes 4 ! 5 !
133-3 - De ma1 Exposure
TEP
A,B,C,FPG
No
—
Yes 4 / 5 !
133—4 — Inhalation Exposure
TEP
A,B,C,F,G
No
—
yes 4 /5!
1/ Canposition: TEP = Typical end—use product.
2/ The use patterns are coded as fol lc ,s: A=Terrestri al, Food Crop; B=Terrestrial, Non—Food; C=Aquat ic, Food Crop:
D=Aquat Ic, Non—Food: E=Greenhouse, Food F=Gr ouse, Non—Food; G=Forestry; H=Danest i c Outdoor; 1=1 ndoor.
3/ Data must be sul itted no later than I I
4/ An interim 24 hour reentry interval is imposed for these use patterns pending the receipt and evaluation of
reentry data. rkers may reenter within that interval if protective clothing is rn.
5/ Analysis of residues should include both qualitative and quantitative assays for oxidative metabolites.
73
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TABLE A
GENERIC DATA RF (JIREMENTS FOR DISULFOITJN
Does EPA Have Data
Must Additional
To Satisfy This
Data Be SutLlnitted
Use
Data Require ent Ccn position 1 / Pattern 2 !
Requir nent? (Yes,
No or Partially)
Bibliographic
Citation
Under FIFRA Section
3(c)(2)(B)? 3 /
§158.142 Aerial Spray Drift
201.1 — Droplet Size Spectrum
Testing TEP A,B,C,D,G No Yes
202.1 — Drift Field Evaluation TEP A,B,C,D,G No Yes
1/ Ccii posit ion: TEP = Typical end-use product.
2/ The use patterns are coded as foll s: A=Terrestrial, Food Crop; Terrestrial, Non—Food; C=Aquatic, Food Crop:
D=Aquat Ic, Non—Food: E=Greenhouse, Food Crc2; F=Greenhouse, Non-Feed; G=Forestry, H=Da est ic Outdoor, 1= Indoor.
3/ Data must be sutmitted no later than OLC 1986
74
-------
Data Requir ent
§158.145 Wildlife and
Aquatic Organ i ns
AVThN AND MAMMALIAN TESTING
71—1 — Avian Oral
71—2 — Avian Dietary
a—Waterf il
b.Upland game
71—3 — Wild Mamal Toxicity
71-4 — Avian Repr x1uction
71—5 - Simulated and Actual
Field Testing —
Mamals and Birds
P (JATIC O1 ANISM TESTING
72—1 — Acute Freshwater Fish
a. Wanuwater
TGAI A,B,G,H
I GAI A,B,G,H
0006 826 8**a/ No
00003503**
0006826 8**a/
00003503**
TABLE A
GENERIC D7 TA RB (JIREMENI’S FOR DI JLFO1DN
Does EPA Have Data
To Satisfy This
Requir ent? (Yes,
No or partially)
Must Additional
Data Be
Section
Use
cC 1 OSitionV Pattern 2 !
Bibliographic
Citation
Under FIFRA
3(c)(2)(B)? 3 /
I GAI
A,B,G,H
Yes
00095655 *a/
GS0102700*
05008363**
IGAI
A,B,G,H
Yes
00094233 *a/
00058746*
Reserved 4 /
ICAI
A,B,G,H
Yes
0009 4233*a!
Reserved 4 !
ICAI
A,G
No
Reserved 4 !
TGAI
A ,B ,G
No
Reserved 5 !
TEP
A
Partially
OOO9 5 6S8 ’ W
0009565 7**W
Yes 6 !
b. Coldwater
Yes
Yes
No
75
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TABLE A
GF ERIC DATA REX IJIRE21EN’IS FOR DISULFtYIt)N
Does EPA Have Data
Must Additional
To Satisfy This
Data Be Sutinitted
Use
Data Requiranent Canposition 1 / Pattern 2 /
Requirenent? (Yes,
No or Partially)
Bibliographic
Citation
Under FIFRA Section
3(c)(2)(B)? 3 /
§158.145 Wildlife arid
uatic Organi ns
(continued)
? QUATIC OI ANISM IESTI (continued)
72—2 — Acute Freshwater
Invertebrates 1 3AI A,B,G,H Partially 7 ’ 00003503** Yes
72—3 — Acute Estuarine
and Marine Organi ns
a. Shrimp IGAI A,B No Yes 8 !
b. Marine fish TGAI AB No Yes 8 !
c. Oyster I AI A,B No Yes 8 /
72—4 — Fish Early Life Stage
and Aquatic Invertebrate
Life-Cycle 1t AI A,B No Reserved 4 !
72—5 — Fish Life—Cycle RAI A,B No Reserved 4 ! 6 / 9 !
72-6 — Aquatic Organi n
Accumulation IGAI A,B No Reserved 4 ’
72—7 — Simulated or Actual
Field Testing —
Aquatic Organ i ns TEP A,B No Reserved 4 ’
76
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TABLE A
GENERIC DATA RE (JIREME flS RJR DIStJLRYIt N
§158.145 Wildlife and
Aquatic Organisi s
(continued)
1/ Ccznposition: ‘IGAI — Technical grade of the active ingredient; PAT = pure active ingredient;
TEP = Typical end—use product
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop; BTerrestrial, Non—Food Crop;
C=Aquatic, Food Crop; D=Aquatic, Non-food; E=Greenhouse, Food Crop; F=Greenhouse, Non—Food;
G=Forestry; H=Donestic Outdoor I=Indoor.
3/ Data must be submitted no later than ________________________
4/ Reserved pending results of metaboli u data. Toxicity studies on metabolites may be required.
5/ Reserved pending indication of Environmental Fate information.
6/ Field studies are required due to the toxicity of the chemical in relation to expected environmental concentrations.
At this time three field monitoring studies are required: One for the use of the 15% granular product on a crop
with higher use rates, one for the use of the emulsifiable concentrate band treatment on a crop with a higher use
rates and one for the broadcast foliar application. Depending on the results of studies, further testing on
additional crops may be necessary.
7/ A more sensitive life stage must be tested.
8/ Disulfoton has LCSO values below 1 ppn for aquatic invertebrate and fish. Several crops are grown in excess of
300,000 acres in coastal counties. The following dlsulfotai uses meet this requirement: corn, soybean, sorghum
and cotton.
9/ Reserved pending results of test 72—4.
Study on its own fulfills Guideline Requirement
** Study must be canbined with other studies to fulfill Guideline Requirement.
a) Studies submitted by Mobay Chemical Corp. These data may be cai pensable.
77
-------
TABLE A
GE2 ERIC DATA REX UIREMENIS FOR DIStJLFtTR!4
Does EPA Have Data
To Satisfy This
Must Additional
Data Be suth itted
Use
Data Require nent Canposition 1 ! Pattern 2 !
Requir nent? (Yes,
No or Partially)
Bibliographic
Citation
Under FIFRA Section
3(c)(2)(B)?
§158.155 Nontarget Insect
NCt T ET INSECT TESTING -
POLLINNIORS :
141—1 — Honey bee acute
contact I GAI A,B Yes 00066220a/
05001991
05004151
141—2 — Honey bee — toxicity
of residues on
foliage TEP A,B No Yes
141-4 — Honey bee subacute
feeding study (Reservedj 4 /
141—5 — Field testing for
pollinators (Reserved] 4/
142—1 — Acute toxicity to
aquatic insects [ Reserved] 5/
142—2 — Aquatic insect
life-cycle study [ Reserved] 5 !
142—3 — Simulated or actual
field testing for
aquatic insects [ Reserved ) 5 !
78
-------
TABLE A
GENERIC DATA REX JIREMEN1S Et)R DISULFUI JN
Does EPA Have Data
To Satisfy This
Must Additional
Data Be sutxnitted
Use
Data Requir nent Ccitiposition 1 / pattern2/
Requirenent? (Yes,
No or Partially)
Bibliographic
Citation
Under FIFRA Section
3(c)(2)(B)?
§158.155 Nontarget Insect
INSECT TESTING —
POLLINATORS :
143—1 — NCNrAWET INSECT TESTINX
thru PRED IORS AND PARASITES
143—3 [ Reserved) 5 ’
1/ Canposition: U3A 1 = Technical grade of the active ingredient; TEP = Typical end—use product.
2/ The use patterns are coded as fol lows: A=Terrestrial, Food Crop; B=Terrestrial, Non—Food; C=Aquat Ic, Food Crop:
D=Aquat i c, Non-Food; E=Greenhouse, Food Croj F re ) use, Non—Food; G=Forest ry; H=Danest i c Outdoor; 1=1 ndoor.
3/ Data must be sutmiitted no later than ______________________
4/ Reserved pending developnent of test method.
5/ Reserved pending Agency decision as to whether data requir nent should be established.
a) Studies sulznitted by Penick Corp. These data may be canpensable.
79
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TABLE B
PROWC SPECIFIC DATA REXYJIREMENIS FOR MANUFACJXJRING-USE P1 )WC1’S CtNTAINII G DISULFUITJN
Data Require ent
§158.120 — Product Chanistry
Product Identity :
61—1 — Identity of Ingredients
61—2 — Statenent of Canposition
MP
MP
MP
R
R
R
[ x l
[ Xl
LX ]
[ xl
[ Xl
[ xl
[
[ 1
(1
[ 1
F]
Test
Substance 1 !
Guidelines
Status2/
Are Data
Required 3 /
Yes No
Footnote
Ni unber
MP
R
[ ]
[ =1
M I ’
R
[ X I
(]
t’IP
R
[ ]
CI
61—3 — Discussion of Fonnation of
Ingredients
Analysis and Certification of Product
Ingredients
62—1 — Preliminary Analysis
62—2 — Certification of Limits
62—3 — Analytical Methods for
Enforc nent of Limits
Physical and Chanical Characteristics
63—2 — Color
63—3 — Physical State’
63—4 — Odor
MI’
MI’
R
R
R
80
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TABLE B
PI DDUC SPECIFIC D A RB UIREMENTS FOR MANUFACIURIM3-USE P1 Jt1JC1’S CO AINING DISULRY1t
Guideline Citation and
Name of Test
Data Require nent
§158.120 — Product Chenistry (cont’d)
Physical and Chenical Characteristics
(Continued)
63—7 — Density, Bulk Density, or
Specific Gravity
Test
Substance’!
Guidelines
Status 2 ’
Are Data
Required 3 !
Yes No
Footnote
Number
CR
MP
R
[ ]
E_]
NP
R
[ ]
[ =1
NP
[ ]
NP
E ]
NP
NP
E ]
E ]
NP
NP
( ]
[ I
NP
E ]
63—12
— pH
63—14
— Oxidizing or Reducing
Act ion
LI
63—15
— Fianunability
CR
[ TI
63—16
— Explodability
R
[ I
63—17
— storage stability
R
0
63—18
— Viscosity
CR
[ TI
63—19
— Miscibility
CR
[ 1
63—20
— Corrosion Characteristics
R
[ I
Other
Requ i r nents:
— Subnittal of samples PA l CR
64— 1
[ I [ i:]
81
-------
TABLE B
P DWC SPECIFIC DATA RE (JIREMENI’S F R MANUFACIURIt -USE P DWCTS JWTAINIt DISLJLFUI N
§158.120 — Prx uct Chenistry (cont’d)
1/ Test Substance: MP= Manufacturing—use Product; PAI= Pure active ingredient;
Choice= Choice of several test substances on a case-by—case basis.
2/ Guideline Status: R= Required; CR Conditionally required
3/ Data must be sutinitted t y 1985
82
-------
TABLE B
PF DWCI’ SPECIFIC D A RB UIREMENIS FOR MANUFACTURING USE P1 X11CIS (fl’ffAINING DI JLFU [ ’ON
Does EPA Have Data
Must Additional
To Satisfy This
Data be Sutziutted
Requir eflt? (Yes,
Data Requiranent Ccznposition No or Partially)
Bibliographic
Citation
Under FIFRA Section
3(c)(2)(B)? 1/
§158.135 Toxicology
AC JTE TESTING
81—1 — Oral Granular containing 2% ai No Yes
Granular containing 2.2% ai No Yes
Granular containing 5% ai No Yes
E nu1sifiable conc. cont. 68% ai No Yes
81—2 — Detmal Granular containing 2% ai No Yes
Granular containing 2.2% ai No Yes
Granular containing 5% ai No Yes
E u1sifiable conc. cont. 68% ai No Yes
81—3 — Inhalation Granular containing 2% ai No Yes
Granular containing 2.2% ai No Yes
Granular containing 5% ai No Yes
Dttulsiflable cone. cont. 68% ai No Yes
81—4 - Primary Eye Granular containing 2% ai No Yes 2 !
Irritation Granular containing 2.2% ai No Yes 2 !
Granular containing 5% ai No Yes 2 !
nu1sifiab1e conc. cont. 68% ai No Yes 2 !
81—5 — Primary Granular containing 2% ai No Yes 2 !
Dermal Granular containing 2.2% ai No Yes 2 !
Irritation Granular containing 5% ai No Yes 2 !
E nulsifiable cone. cont. 68% ai No Yes 2 !
81—6 — DeLma l Granular containing 2% ai No
Sensitiza— Granular containing 2.2% ai No No 3 !
tion Granular containing 5% ai No N&!
E)nulsifiable cone. cont. 68% ai No No 3 !
83
-------
TABLE B
P1 )WCF SPECIFIC DATA R )UIREME T S Ft)R MANUFAC11JRI USE P1 XIJCTS C T AINING DISULFUION
§158.135 Tbxicology
(continued)
1/ Data must be suhnitted no later than _______________________
2/ Testing is contingent upon toxicity category as determined 1 the acute oral, detmal and inhalation toxicity.
Chemicals in toxicity category I are not to be tested for their eye or deunal irritating potential.
3/ The chemical structure of disulfoton does not indicate a possible dermal sensitization potential. The inerts
used in the formulations do not seen to have skin sensitization potential.
84
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TABLE C
P WCr SPECIFIC DATA REQUIREMENTS FOR D-USE P X1JCI’S J AINING DISULF(YIt)N
E ta I quirement
canposition 1 /
Exes EPA Have E ta
1b Satisfy This
Requirement? (Yes,
No or Partially)
Bibliographic
Citation
Must Piiditional
E ta be Sutmitted
Under FIFRA Section
3(c)(2)(B)
§158.135 PDxicology
ACITrE TESTING
81—1 — Acute Oral Thxicity
Rat
EP
No
—
yes /
81—2 - Acute t zTnal Ibxicity
EP
No
—
Yes 3 ’
81—3 — Acute Inhalation
1 ’Dxicity — Rat
EP
No
—
Yes 3 !
1/ Canpos it ion: EP = end—use product.
2/ t ta must be subnitted no later than June 1985 .
3/ (a) For new end—use granular products greater than 2.0% disulfoton. Either these data must be sut nltted and
evaluated prior to registration or the products must be labeled for restricted use.
(b) For currently registered end—use granular products containing greater than 2.0% disulfoton. These products
must be labeled for restricted use pending receipt and evaluation of these data.
(c) For new currently registered end—use granular products containing 2.0% disulfoton or less. tata must be
sutznitted in order to evaluate the appropriate toxicity category and to consider the appropriateness of
classifying these products for restricted use.
5.
-------
IV. SUBMISSION OF REVISED LABELING INFORMATION
Note : This section applies to all products containing
disul foton.
FIFRA requires each product to be labeled with accurate,
complete and sufficient instructions and precautions, reflecting
the results of data concerning the product and its ingredients.
Labeling requirements are set out in 40 CFR 162.10 (see
Appendix IV—1) and are summarized for products containing
this active ingredient as part of this Guidance Document
(See Appendix IV—2). Applications submitted in response to
this notice must include draft labeling for Agency review.
If you fail to submit revised labeling information
complying with this section and/or Section I, EPA may issue
a notice of intent to cancel the registration under FIFRA
sec. 6(b)(1).
A. Label Contents
40 CFR 162.10 requires that certain specific labeling
statements appear at certain locations on the label. This
is referred to as format labeling . Specific label items
listed below are keyed to Appendix IV—2.
Item 1. PRODUCT NAME — The name, brand or trademark is
required to be located on the front panel, preferably centered
in the upper part of the panel. The name of a product will
not be accepted if it is false or misleading.
Item 2. COMPANY NAME AND ADDRESS — The name and addr&ss
of the registrant or distributor is required on the label.
The name and address should preferably be located at the
bottom of the front panel or at the end of the label text.
Item 3. NET CONTENTS — A net contents statement is
require on all labels or on the container of the pesticide.
The preferred location is the bottom of the front panel
immediately above the company name and address, or at the end
of the label text. The net contents must be expressed in the
largest suitable unit, e.g., “1 pound 10 ounces” rather than
“26 ounces.” In addition to English units, net contents may
be expressed in metric units. See Appendix IV—l. [ 40 CFR
162.10(d)]
Item 4. EPA REGISTRATION NUMBER — The registration
number assigned to the pesticide product must appear on the
label, preceded by the phrase “EPA Registration No.,” or “EPA
Reg. No.” The registration number must be set in type of a
86
-------
size and style similar to other print on that part of the
label on which it appears and must run parallel to it. The
registration number and the required identifying phrase must
not appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Agency. See Appendix IV—l.
[ 40 CFR 162.10(e)]
Item 5. EPA ESTABLISHMENT NUMBER — The EPA establishment
number, preceded by the phrase EPA Est.” is the final estab—
lishrnent at which the product was produced, and may appear
in any suitable location on the label or immediate container.
It must also appear on the wrapper or outside container of
the package if the EPA establishment number on the immediate
container cannot be clearly read through such wrapper or container.
See Appendix IV—1. [ 40 CFR 162.10(f))
Item 6. INGREDIENTS STATEMENT — An ingredients statement
is required on the front panel and must contain the name and
percentage by weight of each active ingredient and the total
percentage by weight of all inert ingredients. The preferred
location is immediately below the product name. The ingredients
statement must run parallel with, and be clearly distinguished
from, other text on the panel. It must not be placed in the
body of other text. See Appendix IV—l. [ 40 CFR 162.10(g)]
Item 6A. POUNDS PER GALLON STATEMENT — For liquid agricul-
tural formulations, the pounds per gallon of active ingredient
must be indicated on the label.
Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS — Front panel
precautionary statements must be grouped together, preferably
within a block outline. The table below shows the minimum’type
size requirements for various size labels.
Size of Label Signal Word as Re— “Keep Out of Reach
on Front Panel quired Minimum Type of Children”
in Square Inches Size All Capitals as Required
5 and under 6 point 6 point
above 5 to 10 10 point 6 point
above 10 to 15 12 point 8 point
above 15 to 30 14 point 10 point
over 30 18 point 12 point
Item 7A. CHILD HAZARD WARNING STATEMENT — The statement
“Keep Out of Reach of Children” must be located on the front
panel above the signal word except where contact with children
during distribution or use is unlikely. See Appendix iV—l.
[ 40 CFR 162.10(h) ( 1)( ii))
Item 7B. SIGNAL WORD — The signal word (Caution, warning,
or Danger) is required on the front panel immediately below
the child hazard warning statement. See Appendix IV—1.
[ 40CFR162.lO(h)(l)(i)]
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Item 7C. SKULL & CROSSBONES AND WORD “POISON” — On products
assigned a toxicity Category I on the basis of oral, dermal,
or inhalation toxicity, the word “Poison” shall appear on the
label in red on a background of distinctly contrasting color and
the skull and crossbones shall appear in immediate proximity to
the word POISON. See Appendix 1V—l. [ 40 CFR 162.l0(h)(l)(i)]
Item 7D. STATEMENT OF PRACTICAL TREATMENT - A statement
of practical treatment (first aid or other) shall appear on
the label of pesticide products in toxicity Categories I,
II, and III. See Appendix IV—l. [ 40 CFR l62.lO(h)(l)(iii))
Item 7E. REFERRAL STATEMENT — The statement “See Side
(or Back) Panel for Additional Precautionary Statements” is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
See Appendix IV—l. [ 40 CFR 162.l0(h)(l)(iii)]
Item 8. SIDE/BACK PANEL PRECAUTIONARY LABELING — The
precautionary statements as listed below must appear together
on the label under the heading “PRECAUTIONARY STATEMENTS.”
The preferred location is at the top of the side or back
panel preceding the directions for use, and it is preferred
that these statements be surrounded by a block outline. Each
of the three hazard warning statements must be headed by the
appropriate hazard title. See Appendix IV—l. [ 40 CFR 162.10
(h) (2)]
Item 8A. HAZARD TO HUMANS AND DOMESTIC ANIMALS — Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route(s) of exposure and the precautions to be taken to avoid
accident, injury or damage. See Appendix IV—l. [ 40 CFR 162.10
(h)(2) (i))
Item 8B. ENVIRONMENTAL HAZARD — Where a hazard exists to
non—target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, injury, or damage. See Appendix IV—l. [ 40 CFR
162.10(h) (2) (ii)]
Item BC. PHYSICAL OR CHEMICAL HAZARD
1. Flammability statement . Precautionary statements relating
to flammability of a product are required to appear on the
label if it meets the criteria in Appendix IV—3. The require-
ment is based on the results of the flashpoint determinations
and flame extension tests required to be submitted for all
products. These statements are to be located in the side/back
panel precautionary statements section, preceded by the
heading SiPhysical/Chemical Hazards.” Note that no signal
word is used in conjunction with the flammability statements.
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2. Criteria for declaration of non—flammability . The
following criteria will be used to determine if a product
is non—flammable:
a. A “non—flammable gas” is a gas (or mixture of gases)
that will not ignite when a lighted match is placed
against the open cylinder valve.
b. A “non—flammable liquid” is one having a flashpoint
greater than 350°F (177°C).
C. A non—flauunable aerosol” is one which meets the
following criteria:
i. The flame extension is zero inches;
ii. There is no flashback; and
iii. The flashpoint of the non—volatile liquid
component is greater than 350°F (177°C).
3. Declaration of non—flammability . Products which
meet the criteria for non—flammability specified
above may bear the notation “non—flammable” or “non-
flammable (gas, liquid, etc.)” on the label. It may
appear as a substatement to the ingredients statement,
or on a back or side panel, but shall not be highlighted
or emphasized (as with an inordinately large type
size) in any way that may detract from precaution.
4. Other physical/chemical hazard statements . When
chemistry data demonstrate hazards of a physical or
chemical nature other than flammability, appropriate
statements of hazard will be prescribed. Such statements
may address hazards of explosivity, oxidizing or reducing
capability, or mixing with other substances to produce
toxic fumes.
Item 9 . PRODUCT CLASSIFICATION — Section 3(d) of FIFRA
requires that all pesticide formulations/uses be classified
for either general or restricted use, and that those uses
classified as restricted be limited to use by certified
applicators or persons under their direct supervision (or
subject to other restrictions that may be imposed by regulation).
In the Registration Standard, the Agency has (1) indicated
certain formulations/USeS to be restricted, based either on a
previous classification determination made through the optional
procedures of 40 CFR 162.30 or based on data already available
to the Agency, or (2) reserved any classification decision until
appropriate data are submitted.
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The Regulatory Position and Rationale states whether
products containing this active ingredient are classified
for restricted use. If they are restricted the draft label(s)
submitted to the Agency as part of your application must
reflect this determination (see below).
If you wish to propose that your product should not be
classified for restricted use, you must submit any information
and rationale with your application for reregistration.
During the Agency’s review of your application, your proposed
classification determination will be evaluated in accordance with
the provisions of 40 CFR 162.11(c). You will be notified of
the Agency’s classification decision.
A. Classification Labeling Requirements
1. All Uses Restricted — Pesticide products bearing
directions for use for formulations or uses classified
restricted shall bear statements of restricted use classi-
fication on the front panel as described below:
a. The statement “RESTRICTED USE PESTICIDE,”
must appear at the top of the front panel of the
label, set in type of the same minimum sizes as
required for human hazard signal words (see table in
40 CFR 162.l0(h)(l)(jv).
b. Directly below this statement on the front
panel, a summary statement of the terms of restric-
tion shall appear. If use is restricted to certified
applicators, the following statement is required:
“For retail sale to and use only by Certified App1 cators
or persons under their direct supervision and only
for those uses covered by the Certified Applicator’s
Certification.”
2. Some But Not all Uses Restricted — If the Regula-
tory Position and Rationale states that some uses are
classified for restricted use and some uses are unclassified,
several courses of action are available:
a. You may label the product for restricted use.
If you do so, you may include those uses that are
unrestricted, but you may not distinguish them on
the label as being unrestricted.
b. You may delete all restricted uses from your
label and submit draft labeling bearing only unres-
tricted uses.
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c. You may “split” your registration, i.e.,
register t separate products with identical formula-
tions, one containing only unrestricted uses, and
the other restricted uses. 1’D do so, subnit t
applications for reregistration, each containing all
forms and necessary labels. th applications should
be sul:initted simultaneously. Note that the product
names will be assigned separate registration nutibers.
B. Canpliance Schedules
No product with a use classified for restricted use
under this Standard may be released for shipnent by the
registrant or producer after September 1, 1985, without
bearing the restricted use classification. All products
still in channels of trade after September 1, 1986, must be
labeled for restricted use.
Item 1OA. SIORN E AND DISPOSAL BLOCK - All labels are
required to bear storage and disposal statements. These
stat nts are developed for specific containers, sizes, and
chemical content. These instructions must be grouped and
appear under the heading “Storage and Disposal” in the directions
for use. This heading must be set in the same type sizes as
required for the child hazard warning. Refer to Appendix
Iv—4 to determine the disposal instructions appropriate for
your products.
Item lOB. DIRECTIONS FOR USE - Directions for use must
be stated in terms which can be easily read and understood by
the average person likely to use or to supervise the use of
the pesticide. 4ien follo d, directions must be adequate to
protect the public fran fraud and fran personal injury and to
prevent unreasonable adverse effects on the envi rorment • See
Appendix P1—1. [ 40 CFR 162.10]
B. ( Yllateral Labeling
Bulletins, leaflets, circulars, brochures, data sheets,
flyers, or other graphic printed matter which is referred to
on the label or which is to accanpany the product are termed
collateral labeling. Such labeling may not bear claims or
representations that differ in substance fran those accepted
in connection with registration of the product. It should be
made part of the response to this notice and sulmiitted for
review.
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V. INSTRUCTIONS FOR SUBMISSION
All applications prepared in response to this Notice should
be addressed as follows:
George T. LaRocca
Product Manager (15)
Registration Division (TS—767C)
Office of Pesticide Programs
Environmental Protection Agency
Washington, D.C. 20460
Phone No. (703) 557—2400
For each product for which continued registration is desired:
A. For Manufacturing Products (MP) containing only disulfoton
as an active ingredient.
1. Within 90 days from receipt of this document, you must
submit the “FIFRA Section 3(c)(2)(B) Summary Sheet” EPA
Form 8580—1. Refer to Appendix 11—3 with appropriate
attachments.
2. Within 6 months from receipt of this document you must
submit:
a. Confidential Statement of Formula, EPA Form 8570—4.
b. Product Specific Data Report, EPA Form 8580—4
(Appendix 111—1).
c. Two copies of any required product—specific da ta.
d. Two copies of draft labeling, including the label and
associated brochures. If current labeling conforms
to the requirements of this guidance document and the
results of the short—term data, you may submit such
labeling. End use product labeling must comply specif-
ically with the instructions in Section II (Regulatory
Position and Rationale) of this guidance document.
The labeling should be either typewritten text on 8—1/2
x 11 inch paper or a mockup of the labeling suitable
for storage in 8—1/2 x 11 inch files. The draft label
must indicate the intended colors of the final label,
clear indication of the front panel label, and the intended
type sizes of the text.
e. Evidence of compliance with data support requirements
of FIFRA sec. 3(c)(l)(D). Refer to PR Notice 84—4 (enclosed)
for latest requirements.
3. Within the times set forth in Table A , all generic data
must be submitted.
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Note : If for any reason any required test is delayed or
aborted so that meeting the agreed submission time will be
delayed, notify the Product Manager.
B. For Manufacturing Use Products containing Disulfoton in
combination with other active ingredients.
1. Within 90 days from receipt of this document, you must
submit the •‘FIFRA Section 3(c)(2)(B) Summary Sheet” EPA
Form 8580—1. Refer to Appendix 11—3 with appropriate
attachments.
2. Within the times set forth in Table A , all generic
data must be submitted.
Note : If for any reason any required test is delayed or
aborted so that meeting the agreed submission time will be
delayed, notifiy the Product Manager.
C. For End Use products containing disulfoton alone or in
combination with other active ingredients:
1. Within 90 days from receipt of this document, you must
submit the “FIFRA Section 3(c)(2)(B) Summary Sheet” EPA
For 8580—1. Refer to Appendix 11—3 with appropriate
attachments.
2. Within 6 months from receipt of this document you must
s u bm i t:
a. Confidential Statement of Formula, EPA Form 8570—4.
b. Product Specific Data Report, EPA Form 8580—4
(Appendix 111—1).
c. Two copies of any required product—specific data.
(Refer to Table C)
d. Two copies of draft labeling, including the label and
associated brochures. If current labeling conforms
to the requirements of this guidance document and the
results of the short—term data, you may submit such
labeling. End use product labeling must comply specif-
ically with the instructions in Section II (Regulatory
Position and Rationale) of this guidance document.
The labeling should be either typewritten text on 8—1/2
x 11 inch paper or a mockup of the labeling suitable
for storage in 8—1/2 x 11 inch files. The draft label
must indicate the intended colors of the final label,
93
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clear indication of the front panel label, and the intended
type sizes of the text.
e. Evidence of compliance with data support requirements
of FIFRA sec. 3(c)(l)(D). Refer to PR Notice 84—4 (enclosed)
for latest requirements.
3. For those end use product registrations that are not
eligible for the formulations exemption [ FIFRA sec. 3(c)(2)(D)],
submit all generic data within the time set forth in Table A.
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Appendix It—i
Guide to Use of This Bibliography
1. XX9TE T OF BIBLIOGRAPHY. This bibliography contains
citations of all studies considered relevant by EPA in
arriving at the posit ions and conclusions stated elsewhere
in the Standard. Primary sources for studies in this
bibliography have been the body of data suirtitted to EPA
and its predecessor agencies in support of past regulatory
decisions. Selections fra n other sources including the
published literature, in those instances where they have
been considered, will be included.
2. UNITS OF ENrRY. The unit of entry in this bibliography
is called a “study.” In the case of published materials,
this corresponds closely to an article. In the case of
unpublished materials sulnitted to the Agency, the Agency
has sought to identify documents at a level parallel to
the published article fra n within the typically larger
volumes in which they were sut nitted. The resulting
“studies” generally have a distinct title (or at least a
single subject), can stand alone for purposes of review,
and can be described with a conventional bibliographic
citation. The Agency has att npted also to unite basic
documents and caiinentaries upon then, treating thai as a
single study.
3. IE NTIFICATION OF ENTRIES. The entries in this bibliography
are sorted numerically by “Master Record Identifier,” or
MRID, number. This number is unique to the citation, and
should be used at any time specific reference is required.
It is not related to the six—digit “Accession Number”
which has been used to identify volumes of sul itted
studies; see paragraph 4(d)(4) below for a further explana-
tion. In a few cases, entries added to the bibliography
late in the review may be preceded by a nine—character
t nporary identifier. These entries are listed after
all MRID entries. This t nporary identifier number is
also to be used whenever specific reference is needed.
4. FDRM OF ENTRY. In addition to the Master Record Identifier
(MRID), each entry consists of a citation containing
standard el ents followed, in the case of material
sut nitted to EPA, by a description of the earliest known
sutknission. Bibliographic conventions used reflect the
standards of the American National Standards Institute
(ANSI), expanded to provide for certain special needs.
-------
Appendix 11—1 (continued)
a. Author. Whenever the Agency could confidently identify
one, the Agency has chosen to show a personal author.
When no individual was identified, the Agency has
s} in an identifiable laboratory or testing facility
as author. As a last resort, the Agency has st own
the first suhuitter as author.
b. i cument [ ate. When the date appears as four digits
with no question marks, the Agency took It directly
fran the doc ment. When a four—digit date is foll d
by a question mark, the bibliographer deduced the
date fran evidence in the document. When the date
appears as (19??), the Agency was unable to determine
or estimate the date of the document.
c. Title. In sane cases, it has been necessary for
Agency bibliographers to create or enhance a doci.ment
title. Any such editorial insertions are contained
between square brackets.
d. Trailing Parentheses. For studies suhnitted to the
Agency in the past, the trailing parentheses include
(in addition to any self—explanatory text) the fol-
lowing elements describing the earliest known sutinissiori:
(1) Su znission I te. The date of the earliest known
su1 ission appears ii mediately following the word
“received.”
(2) Administrative Number. The next el ent,
inunediately following the word “under,” is the
registration number, experimental use permit
number, petition number, or other administrative
number associated with the earliest known subuission.
(3) SuLiuitter. The third el nent is the sutinitter,
following the phrase “sutinitted by.” When
authorship is defaulted to the sutinitter, this
ela nent is cinitted.
(4) Volume Identification (Accession Numbers). The
final el nent in the trailing parentheses
identifies the EPA accession number of the volume
in which the original sutinission of the study
appears. The six-digit accession number follows
the symbol “CDL,” standing for “Canpany I ta
Library.” This accession number is in turn
followed by an alphabetic suffix which shows the
relative position of the study within the volume.
For example, within accession number 123456, the
first study would be 123456—A; the second, 123456—
B; the 26th, l23456—Z; and the 27th, 123456—AA.
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Appendix 11—1
OFFICE OF PESTICIDE P1 XRAMS
PEGISTRATIC STANDARD BIBLICX3RAPHY
Citations Considered to be Part of the Data Base Supportieg
Registrations Under the Disulfoton Standard
00002477 Eli Lilly arid Canpany (1972) Isopropalin—Tobacco: Isopropalin as a
Herbicide for Tobacco in Cathination with Diazinon, Di—Syston,
arid Prophos. Includes undated method entitled: The determina-
tion of Disyston, Diazinon and Mclap in tobacco plants; Method
no. 5801590 dated Jan 20, 1970 entitled: Determination of can-
pound EL—179 (2,6—Dinitro-N,N—diprcpylcurnidine) in agricultural
crops. (Unpublished study received Apr 2, 1973 under 1471—79;
prepared in cooperation with WARF Institute, Inc., sutinitted by
Elanco Products Co., Div. of Eli Lilly and Co., Indianapolis,
md.; (I)L:101603—A)
00003503 Johnson, W.W.; Finley, M.T. (1980) Handbook of Acute Toxicity of
Chemicals to Fish and Aquatic Invertebrates, U.S. Dept. of the
Interior, Fish and Wildlife Service, Resorce Publication
137: p. 34
00013487 McCarty, R.T.; Haufler, M.; Osborn, M.G.; et al. (1969) Oral toxic-
ity of Four Organophosphate Insecticides to Farm Livestock.
M rican Journal of Veterinary Research 30(7):1149—1153. (Re-
port no. 25425; also in unpublished sutxnission received May 3,
1971 under 1F1166; sutinitted by Chemagro Corp., Kansas City,
Mo.; CDL:090961—K)
00028625 Sininon, V.F. (1979) In vitro Microbiological Mutagenicity and Un-
scheduled LX A Synthesis Studies of Eighteen Pesticides: Report
No. EPA—600/l—79—04l. (Unpublished study includieg sutinitter
suninary, received Apr 3, 1980 under 279—2712; prepared by SRt
International, subnitted by FMC Corp., Philadelphia, Pa. ; CDL:
099350—A)
00028780 Loeffler, W.W. (1970) A Confirmatory Gas Chrcinatographic Procedure
for Di—syston Residue Analysis for Tobacco: Report No. 27714.
(Unpublished study received Jan 25, 1974 under 3125—279; sutinit—
ted by Mobay Chemical Corp., Kansas City, Mo.; CDL:102112—F)
00032409 Kiigeinagi, U.; Wellman, D.; Terriere, L.C. (1968) Residues of Di—
sulfoton and Its Metabolites in Fresh and Dry Hops: Report
No. 24098. (Unpublished study received Aug 8, 1969 under
OF0866; prepared by Oregon State Univ., Dept. of Agricultural
Chemistry, sutmitted by Mobay Chemical Corp., Kansas City, Mo.;
CDL :093163—C)
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Appendix II—].
OFFICE OF PESTICIDE P1 XRAMS
J GISTRATION STANDARD BI BLICXRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Disulfoton Standard
00041055 Thornton, J.S. (1967) Determination of Di—Syston Residues in Vari-
ous Crops and Products: Report No. 21319 • Method dated Oct 27,
1967. (Unpublished study received Oct 23, 1976 under 3125—252,
subnitted by Mthay Ch ical Corp., Kansas City, Mo.; C DL:
095937—F)
00058746 Heath, R.G.; Spann, J.W.; Hill, E.F.; et al. (1972) Canparative
Dietary Toxicities of Pesticides to Birds. By U.S. Fish and
Wildlife Service, Patuxent Wildlife Research Center. Washing-
ton, D.C.: USFWS. (Special scientific report—wildlife no. 152;
sut xnitter report no. 33423; available fran: U.S. Governrr nt
Printing Office: 1972 0—460—531, published study; ( DL:
224691—v)
00066220 Atkins, E.L., Jr.; Anderson, L.D.; Kellum, D.; et al. (1976)
Protecting Honey Bees fran Pesticides. ?: Univ. of California,
Div. of Agricultural Sciences. (Leaflet 2883; also in unpub-
lished sub nission received Mar 20, 1980 under 432—502; sub-
mitted by Penick Corp., Lyndhurst, N.J.; (DL:243536—B)
00068096 Suett, D.L. (1975) Persistence and degradation of Chlorfenvinphos,
Chlormephos, Disulfoton, Phorate and Pirii iphos—ethyl following
spring and late—sun ner soil application. Pesticide Science 6:
385—393. (Also in unpublished sutinission received Dec 17, 1976
under 10182—9; sutxnitted by ICI Americas, Inc., Wilmingtbn,
Del.; CDL:2273].4—O)
00068214 Thornton, J.S.; Hurley, J.B.; Obrist, J.J. (1976) Soil Thin—layer
Mobility of Twenty Four Pesticide Ch nicals: Report No. 51016.
(Unpublished study received Jul 11, 1977 under 3125—315; subnit—
ted by Mobay Chanical Corp., Kansas City, Mo.; CDL:230908—I)
00068268 Lamb, D.W.; Roney, D.J. (1972) Acute Toxicity of Di—syston
Technical, Di—syston 15% Granular and Di—syston 6 lbs/gal Spray
Concentrate to Bluegill and Rainbow Trout: Report No. 34931.
(Unpublished study received Sep 13, 1977 under 3125—183; sub-
mitted by Mobay Ch nica1 Corp., Kansas City, Mo.; (DL:23185l-A)
00071233 Anderson, C.A. (1962) Colorimetric Determination of Di—syston and
Systox Residues in Plant Material: Report No. 8544. (Unpub-
lished study received Feb 4, 1962 under PP0331; sut nitted by
Mobay ChBnical Corp., Kansas City, Mo.; O)L:099937—A)
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Appendix 11—1
OFFICE OF PESTICIDE P XRAMS
REXISTRATICt STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
R istrations Under the Disulfoton Standard
00071237 Anderson, C.A. (1961) Colorimetric Determination of Di—syston
Residues in Plant Material: Report No. 6684. Method dated Jun
2, 1961. (Unpublished study received Feb 4, 1962 under PP0331;
subTlitted by Mc ay Ch nical Corp., Kansas City, Mo.; (DL:
099937—E)
00071243 Anderson, C.A. (1960) Colorimetric Determination of Di—syston and
Systox Residues in Plant Material: II. Application to Potatoes,
Sugar Beets, Sugar Beet Tops, Cabbage, Broccoli, Pineapple, and
Alfalfa: Report No. 5511. Method dated Jul 25, 1960. (Unriib-
lished study received Jan 5, 1961 under PP0256; sutxnitted by
Mobay Chemical Corp., Kansas City, Mo.; CDL:099938—F)
00071245 Razzell, W.E.; Clark, T.P. (1959) A Cholinesterase Assay for De—
termining Residual Insecticides: Report No. 5165. Method dated
Mar 1959. (Unpublished study received Jan 5, 1961 under
PP0256; prepared by British Columbia Research Council, Div. of
Chemistry, subnitted by Mobay Chemical Corp., Kansas City, Mo.;
CDL:099938—H)
00071767 Metcalf, R.L.; Fukuto, T.R.; March, R.B. (1957) Plant metaboliem
of dithio-systox and thimet. Journal of Econa ic Entanology
50(3):338—345. (Also in unpublished sutinission received Apr 28,
1960 under 24l—EX—18; suth itted by American Cyanamid Co.,
Princeton, N.J.; ( DL:123098—A)
00073348 Hoffmann, K.; Weischer, C.H.; Luckhaus, G.; et al. (1975) S 276
(Disulfoton) Chronic Toxicity Study on Dogs (T -year Feeding
Experiment): Report No. 5618; Report No. 45287. (Unpublished
study received Dec 15, 1976 under 3125—58; prepared by Bayer,
PC, W. Germany, sutinitted by Mobay Chemical Corp., Kansas City,
Mo.; DL:095640—N)
00083251 March, R.B.; Fukuto, T.R.; Metcalf, R.L. (1957?) Metaboli n of
P32—Dithio-systox in the White Mouse and American Cockroach:
SuI:xnitter * 1830. (Unpublished study received on unkn in date
under PP0244; prepared by Univ. of California—Riverside, Citrus
Experiment Station, sutxnitted by Chemagro Corp., Kansas City,
Mo.; CDL:098725—F)
00089403 Metcalf, R.L.; Reynolds, H.T.; Winton, M.; et al. (1959) Effects of
temperature and plant species upon the rates of metabolism of
systemically applied Di—syston. Journal of Econanic Entanology
52(3):435—439. (Suhnitter 3635: also in unpublished sutTnission
received Aug 15, 1960 under PP0244; sutinitted by Mcbay Chemical
Corp., Kansas City, Mo.; CDL:090271—P)
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Appendix 11—1
OFFICE OF PESTICIDE P1 XRAMS
1 XISTRATIC STANDARD BIBLICCRAPHY
Citations Considered to be Part of the Data Base Supportirx3
Registrations Under the Disulfoton Standard
00094233 Lamb, D.W.; Jones, R.E. (1973) Toxicity of (R) Dasanit—IR) Di—
syston and Dasanit-Tilliam to Bobwhite Quail and Mallard Ducks:
Report No. 38462. (Unpublished study received Jan 25, 1974
under 3125—252; sut znitted by Mobay Chemical Corp., Kansas City,
Mo.; CDL:02581].—F)
00095498 Mcbay Chemical Corporation (1970) Synopsis of Analytical, Residue,
and Flavor Information on Di—syston Broadcast Application. In-
cludes method dated Oct 27, 1967. Stminary of studies 238287—E,
090533—N and 006061—C through 006061—F. (Canpilation; unpib—
lished study received Aug 19, 1970 under 3125—119; CDL:005820—A)
00095501 Mobay Chemical Corporation (1970) Synopsis of Analytical and
Residue Information on Di—syston Foliar Applications to Pota-
toes. Includes method dated Oct 27, 1967. (Canpilation; un-
published study received Aug 9, 1970 under 3125—119; ( DL:
005873—A)
00095502 Mcbay Chemical Corporation (1971) Synopsis of Analytical and
Residue Information on Di—syston Application to Alfalfa Seed,
Peanuts and Sorghum. Includes method dated Oct 27, 1967. (CaTI-
pilation; unpublished study received Nov 30, 1971 under 3125—
61; (I)L:006002—A)
00095554 Mcbay Chemical Corporation (1968) (R) Di—syston: Analytical and
Residue Information (Corn and Sorghum). (Ccrnpilation; unpib-
lished study received Mar 7, 1968 under 8F0734; CDL:091267—A;
101728; 101727)
00095622 Mobay Chemical Corporation (1969) Synopsis of Analytical and Res-
idue Information on Di—syston Foliar Spray Application to Cot-
ton. Includes method dated Oct 27, 1967. (Canpilation; un-
published study received Feb 3, 1969 under 3125—119; ( DL:
101732—A)
00095655 Shellenberger, T.E. (1969) Letter sent to D.L. Nelson dated Aug 11,
1969: Acute Toxicological Evaluations of Di—syston with Adult
Bobwhite Quail: GSRI Project No. NC—30l; 25525. Final rept.
(Unpublished study received Mar 19, 1971 under unknown adrnin.
no.; prepared by Gulf South Research Institute, suI nitted by
Mobay Chemical Corp., Kansas City, Mo.; CDL:128228—A)
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Appendix 11—1
OFFICE OF PESTICIDE P1 X3RA? tS
1 XI STRATION STANDARD BIBLICX RAPHY
Citations Considered to be Part of the Data Base Supportirr3
Registrations Under the Disulfoton Standard
00095657 Lamb, D.W.; Nelson, D.L. (1971) Toxicity of (R) Di—syston 15%
Granular on Sorghum to Juvenile Bcbwhite Quail under Simulated
Field Conditions: Report No. 31135. (Unpublished study received
Nov 30, 1971 under unknown admin. ro.; sutTuitted by Mt)ay Che n-
ical Corp., Kansas City, Mo.; CDL:128321—A)
00095658 Lamib, D.W.; Nelson, D.L. (1971) Toxicity of (R) Di—syston Spray
Concentrate to Juvenile Bobwhite Quail and New Zealand Rabbits
under Simulated Field Conditions: Report No. 31235. (Unpub-
lished study received Nov 30, 1971 under unknown admin. no.;
sut nitted by Mobay Chemical Corp., Kansas City, Mo.; ( DL:
128321—B)
00095664 Shaw, H.R., II (1975) The Metabolism of Di—Syston in Soil: Report
No. 40234. Rev. (Unpublished study received May 23, 1974 under
3125—183; sutrrtitted by Mobay Chanical Corp., Kansas City, Mo.,
DL:234065—A)
05001991 Stevenson, J.H. (1978) The acute toxicity of unformulated
pesticides to worker honey bees (Apis mellifera—L). Plant
Pathology 27(1) :38—40.
05004151 Stevenson, J.H. (1968) Laboratory studies on the acute contact
and oral toxicities of insecticide to honeybees. Annals of
Applied Biology 6l(3):467—472.
05008363 Hudson, R.H.; Haegele, M.A.; Tucker, R.K. (1979) Acute oral and
percutaneous toxicity of pesticides to mallards: correlations
with mammalian toxicity data. Toxicology and Applied
Pharinacology 47 (3) :451—460.
-------
Appendix ri—i
OFFICE OF PESTICIDE PR)GRAMS
1 XISTRATION STANDARD BI BLICX3RApHy
Citations Considered to be Part of the Data Base Supportiri
Registrations Under the Disulfoton Standard
GSO1O2001 Bull, D.L. (1965) Metabolism of Di—Syston by Insects, Isolated
Cotton Leaves, and Rats • JQJrnai of Ecx)nanic EntaTology
58(2): 249—254
0i02002 Carter, W.; Gortner, W.A. (1958) The Translocatjon of Radioactive
(S 35 ) Bayer 19639 in Pinnneapple Plants. Journal of Econcmic
Entarology 51(6): 905907. (Also in unpublished study received
Decather 2 1960 under petition 0282; suFi itted by Ch nagro Corp.,
Kansas City, MO; I B 113818)
GS0102003 Che agro Corporation (1959) [ Residue Data on Cotton Leaves and Seed]
(Canpilation; unpublished study received on January 19, 1961 under
PPO291; RCB: 113864—5
GS0102004 Metcalf, R.L.; Fukuto, T.R.; March, R.B. (1957) Plant Metabolism of
Dithiosystox and Thimet. Journal of Econanic Entarology 50(3):
338—345. (Also in unpublished study received Feb. 18, 1960 under
petition 0244; sutmitted by Ch agro Corp., Kansas City, MO;
RCB: 113667
GSO1O200S Ridgway, R.L.; Lindquist, D.A.; Bull, D.L. (1965) Effect of Method of
Application on Uptake of Di-Syston by the Cotton Plant. Journal of
Econanic Entaiology 58(2): 349—352
GSO1O2006 Puhi, R.J.; Fredrickson, D.R. (1975) The Metabolism and Excretion of
Di—Syston by Rats. (Unpublished study received on Dec. 15, 1976
under 7Fl895; sutinitted by Ch nagro Agricultural Division, Mobay
Corp., Kansas City, MD; CDL: 095638)
GSO1O2007 Cavagnol, J.C. (1972) Analytical Studies of Di—Syston Formulations
J DAC 55(5): 918—922
-------
Appendix It—i
OFFICE OF PESTICIDE P} )GRAMS
REXIISTRATIa J STANDP RD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations tinder the Disulfoton Standard
GS0102008 Chen ro Corp. (1962) Colorimetric Method for the Determination of
of Di—Syston Residues in Green Coffee Beans. (Unpublished study
received on July 26, 1962 under pp0372; Report No. 9533 by
C.A. Anderson
CS0102009 Ch nagro Corp. (1967) A Study of Possible Interference of Other
Pesticides with the Analytical Method for Di—Syston—Systox on
Crops. Report No. 21606 by JS Thornton. (Unpublished
study received July 9, 1968 under 8F0734; CDL:1l5654)
GSO1O2O1O Ch iiagro Corp. (1967) Determination of Di—Syston Residues in Corn,
Soybeans, Sugarcane, and Sugarcane Product by Thermiionic E nission
Gas Chranatography. Report No. 20109 by J.S. Thornton. (Unpublished
Study received Nov. 9, 1966 under 7F0547; CDL: 114838)
GSO1O2O11 Ch nagro Corp. (1968) Determination of Dasanit Residues in Peanuts by
Therinionic E idssion Gas Chranatography. Report No. 23037 by
T.J. Olson. (Unpublished study received Oct. 23, 1975 under 6F1694;
CDL: 116208)
GS0102012 Chanagro Corp. (1970) An Interference Study on Di—Syston Pesidue
Determination of Alfalfa, Clover, and Potatoes. Report No. 27312
by T.J. Olson. (Unpublished study received July 20, 1976 under
6F1835; CDL: 095330)
GS0102013 Interregional Research Project No. 4 (1982) Petition for Tolerance
for Use in Asparagus Product (PR—1650) Rutgers Univ. New Brunswick,
N.J., received July 28, 1982 under 2E2730.
GS0102014 Talbott, T.D. (1972) S iiiautanated Analysis of Granular Organophosphorous
Pesticide Formulations. Journal Agric. Food ChEn. 20(5): 959—963
GSO1O2O15 Ch nagro Corp. (1961) Stability of Di—Syston Residues During Frozen
Storage. 1 port No. 7147. (Unpublished study received
Sept. 18, 1961 under petition 0331; RCB: 114010
-------
Appendix 11—1
OFFICE OF PESTICIDE P} JGRAMS
REGISTRATION ST NflRD BIBLIOGRAPHY
Citat ions Considered to be Part of the Data Base Supporting
Registrations Under the Disulfoton Standard
GS0102016 Cha agro Corp. (1960) [ Residue Data on Potatoes) (Canpilation;
unpublished study received May 11, 1960 under pp 0256; RCB:
113714—5)
GSO1O2O17 Ch nagro Corp. 1962 [ Residue Data on Pineapple, Rice, Rice, Straw,
Spinach, and Peanuts] (Canpilation: unpublished study received
February 12, 1962 under pp 0350: RCB: 114092)
GS0102018 Chenagro Corp. (1962) [ Residue Data Concerning Alfalfa, Broccoli,
and wheat] (Canpilation: unpublished study received on
April 19, 1962 under pp0358: RCB: 114113)
GS0102019 Chanagro Corp. (1968) [ Petition for fllerance of Di—Syston in or
on Soybeans] (Canpilat ion: unpublished study received under
8F0624; RCB: 115149 and 115152)
GS0102020 Chemagro Corp. (1970) [ Petition for Tolerance of Di—Syston in or
on Peppers) (Canpilation: unpublished study received
February 18, 1970 under 0F0945; 1 B: 116528)
GS0102021 Chemagro Corp. (1966) [ Residue Data Concerning Pecans) (Canpilation:
unpublished study received February 25, 1966 under 6FV478;
RCB: 114554)
GS0102022 Chemagro Corp. (1965) [ Residue Data Concerning Corn) (Ccxnpilation:
unpublished study received March 15, 1965 under SF0443; RCB: 114427)
GS0102023 Chanagro Corp. (1969) [ Residue Data concerning Sorghum Grain)
(Canpilation: unpublished study received February 27, 1969 under
9F0808; RCB: 115959)
GS0102024 Chenagro Corp. (1968) [ Petition to Amend Tolerance on Wheat)
(Canpilation: unpublished study received February 19, 1968 under
8F0707; RCB: 115546)
-------
Appendix 11—1
OFFICE OF PESTICIDE PI )GRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Disulfoton Standard
GS0102025 Chemagro Corp. (1966) [ Residue Data Concerning Clover (green and
hay)] (Ccinpilation: unpublished study received March 4, 1966
under 6F0480; RCB: 114566—7)
GS0102026 Kiigenagi, V; Wellamn, D.; Terrier, L.C. (1968) Residues of
Disulfoton and Its Metabolites in Fresh and Dry Hops.
Report No. 24098. (Unpublished study received Aug. 15, 1979
under 0F0866: sut itted by Chemagro Corp., Kansas City, MO;
RCB: 116208)
GS0102027 Thornton, 3.S. (1976) Effect of Feeding Di—Syston Metabolites
to Dairy Cattle, Report No. 49100. (Unpublished study received
Dec. 15, 1976 under 7F1895: suL itted by Mobay Chemical
Corp., Kansas City, MO; CDL: 095639)
GS0102028 Gunderson, E.L. (1982) Di—Syston Canpliance and Surveillance
Residue Occurrences. (Unpublished study sutinitted under FDA
cover letter dated May 20, 1982; on file in 7F1895
GS0102029 Gunderson, E.L. (1984) Suimiary of Disulfoton and Related Residue
Findings FY 78—83 (Unpublished study sut nitted under FDA cover
letter dated March 30, 1984; on file in 7F1895.
GS0102030 Thornton, J.S.; Fredrickson, D.R. (1975) Effects of Feeding Di—Syston
Metabolites to Chickens. Report No. 4561 (Unpublished study
received Dec. 15, 1976 under 7F1895; sut:xnitted by Mobay
Chemical Corp., Kansas City, MO; CDL: 095638
GS0102031 Mobay Chemical Corp. (1976) [ Petition for Tolerance of Di—Syston
in or on Alfalfa (Green & Hay), Barley (Green Fodder & Straw),
Beans (Vines), Clover (Green & Hay), Corn (Forage & Fodder),
Meat, Fat, and Meat Byproducts of Cattle, Goats, Hogs, Horses,
and Sheep, Milk, Oats (Green Fodder & Straw), Pea (Vines),
Sorghui (Forage & Fodder), Sugar Beets (Tops), Wheat (Green
Fodder & Straw) (Canpilation: unpublished study received
Dec. 15, 1976 under 7F1895; CDL: 006002, 097270, 095637)
-------
Appendix 11—1
OFFICE OF PESTICIDE P1 JGRAMS
REXISTRATIC STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Disulfoton Standard
GS0102032 Chemagro Corporation (1960) Residue and Toxicology Data on Sugar Beets
(Unpublished study received February 8, 1960 under PP0244;
} B 113667
GS0102300 Mjhail, F. (1978) S 276 (Disulfoton) Acute Toxicity Studies, Report
7602a prepared by Bayer, A , Institut fur Toxikologie. Unpublished
study received June 12, 1978. Sutinitted by Mobay Chemical Corp.,
Kansas City, MO.
GS0102301 Hayes, R.H. (1983). Oncogenicity Study of Disulfoton Technical in
Mice. (Unpublished report of study No. 80—271—04 prepared by the
Corporate Toxicology Department Mobay Chemical Corp.; submitted
by Mobay Chemical Corp., Kansas City, MO.
GS0102302 Lamb, D.W.; Nixson, E.J. (1983) E mbryotoxic and Teratogenic Effects
of Disulfoton. (Unpublished study Report No. 81—611—02 received
July 13, 1983; sul:xnitted by Mobay Chemical Corp., Kansas City, MO;
CDL: 250706
GS0102303 Hanna, PJ.,; Dyer, K.F. (1975) Mutagenicity of Organophosphorus
Canpounds in Bacteria and Drosophila: Mutation Research 28:405—420
G50102700 Hill, E.F. (1983) Acute Toxicity of Granular Insecticide to Bobwhite.
Final Report No. IP 3 14—16—0009—82—1830. Patuxent Wildlife , Research
Center Laurel, MD
-------
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C £ I w ry = *Ia = rt t iL w. af in atn t .a . (Thu c ‘a ____
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-------
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4. M firm r u iat EPA nat .nc s reg zantz a? ny tlrm’s crac iJ. if any r a firme nani.c in araqr1cn i3) acov
nave ai e s.acrr7tt ?I lis a in an . ricn 2) accw in zraanas ‘j,r . 4ctras. I snc.retanc EPA vi*I rem imar n
ma m am.r my 1rm mu a orm ivoig an on a? i te crna .mcar A $ac cn 3lc (2)(Sh Th,m ann err
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—
-------
Appendix 111—1
P WCr SPECIFIC DATA REPORT
EPA Registration No. Guidance Document for
Date
I
f
gistration
Guideline No. Name of Test
Test not
required
for my
product
listed
above
(check
be1c )
I am canplying with
data requir nents by
1
(For EPA Use Only)
Accession Numbers
Assigned
Citing MRID#
Sut xnit-
ting
Data
(At—
tached)
§158.20
icr
Q EMISTRY
61—1
Identity of
ingredients
61—2
Stat nent of
canpos it ion
61—3
Discussion of
formation of
ingredients
62—1
Preliminary
analysis
62—2
Certification of
limits
62—3
Analytical methods
for enforcEnent
limits
63—2
Color
63—3
Physical state
63—4
Odor
_______
63—5
Melting point
63—6
Boiling point
63—7
Density, bulk—
density, or
specific gravity
63—8
Solubility
63—9
Vapor pressure
63—10
Dissociation
constant
63—11
Octanol/water
partition
coefficient
63—12
63—13
Stability
63—14
Oxidizing/reducing
reaction
63—15
F1an nabi1ity
63—16
Explodability
63—17
Storage stability
63—18
Viscosity
63—19
Miscibility
-------
Corrosion
Characteristics
63—20
63—21
Dielectric break— I
d n_ 1tage
I
S158. 135
ioxiaxe
-
81—1
Acute oral LD-50,
rat
81—2
Acute dermal
LD—50
81—3
Acute inhalation,
LC—50 rat
81—4
Primaxy eye
irritation, rabbit
81—5
Primary dermal
irritation
81—6
Dermal sensitiza-
tion
-------
APPENDIX IV—2
LAI3ELINU 1td 2 ThN1b ui iiit . FIFRA, AS AMENDED (REFER 1D ThE SAMPLE LABELS EDLIOWING)
ITE 4
LABEL ELE 4E}1T
APPLICABILITY
OF R JIREMENT
PLACE 4ENr ON LABEL
(X)MMFNIS
REX (JIRED
PREFERRED
1.
Product name
All products
Front panel
Center front
panel
2
Canpany name
and address
All products
None
Bottcin front
panel or end
of label text
If registrant is not the producer, must
he qualified by “Packed for . . .,“
“Distributed by. . .,“ etc.
3
Net: contents
All products
None
Rottan front
panel or end
of_label_text
—-
May be in metric units in addition to
U.S. units
4
EPA Est. No.
All products
None
Front panel
Must be in similar type size and run
parallel to other type.
5
EPA Reg. No.
All products
None
Front panel,
inmediatel.y
before or
following
Reg._No.
May appear on the container instead of
the label.
6A
Ingredients
statement
All products
Front panel
Inmediately
following
product_name
Text must run parallel with other text
on the panel.
6B
Pounds/gallon
statement
Liquid products
where dosage
given as lbs.
ai/unit area
Front panel
Directly below
the main
ingredients
statement
7
Front panel
precautionary
statements
All products
Front panel
All front panel precautionary statements
must be grouped together, preferably
blocked.
7A
7B
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
All products
All products
Front panel
Front panel
Above signal
word
Ininediately
below child
Note type size requirements. -
Note type size requirements.
hazard
warning
-------
APPE JDIX P1-2 (continued)
ITF 4
1
LABEL ELE 4ENT
1 APPLICABILITY
OF RE)Q(JIREMENF
PLcE 1E7rr ON LABEL
or)MMENrS
REX)(JIRED
PREFERRED
7C
Skull & cross—
bones and word
POISON (in red)
All products
which are Cat-
egory I based
on oral, der—
mal, or inhala—
tion_toxicity
Front panel
Both in close
proximity to
signal word
7D
Statement of
practical
treatment
All products
in Categories
I, II, and III
Category I:
Front panel
unless refer-
ral statement
is used.
Others;
Grouped with
side panel
precautionary
statements.
Front panel
for all.
7E
Referral
statement
All products
where pre-
cautionary
labe 11 ng
appears on
other than
front_panel.
Front panel
8
Side/back panel
precautionary
statements
All products
None
Top or side
of back panel
preceding
directions
for use
Must be grouped under the headings in
HA, 813, and BC; preferably blocked.
8A
Hazards to
humans and
danestic
anima is
All products
in Categories
I, II, and III
None
Same as above
Must be preceded by appropriate signal
word.
8B
Environmental
hazards
All products
None
Same as above
Environmental hazards include bee
caution where applicable.
-------
APPE 9DIX P /—2 (continued)
II 1
LABEL ELE7IENF
1 APPLICABILflY
OF R XJIR }1EN
PLACf 74ENT ON LABEL
—
REOUIRED
PREFERRED
8C
Physical or
chemical
hazards
All pressurized
products, others
with flash
points under
150° F
None
Same as above
(DMMENFS
9A
Restricted
block
All restricted
products
Top center
of front
panel
Preferably
blocked
Includes a statement of the terme of -
restriction. The words “ RIC1’ED USE
PESTICIDE” must be same type size as
9C
Misuse
statement
All products
Inmediately
following
statement of
classifica-
tion or
ahead of
directions
for use
signal word.
1OA
Re—entry
statement
All
cholinesterase
inhibitors
In the
directions
for use
Ininediately
after misuse
statement
1OC
Storage and
disposal block
All products
In the
directions
for use
Inmediate ly
before
specific
directions
for use or
at the end of
directions
for use
Must be set apart and clearly distin—
guishable fr-cm frau other directions
for use.
1OD
U.S.
Directions
for use
All products
None
None
May be in metric as well as U.S. units
-------
Appendix IV—3
PHYSICAL-CHEMICAL HAZARDS
Criteria
Required Label Statement
I. Pressurized Containers
A. F].ashpoint at or below
20°F; or if there is a
flashback at any valve
opening.
B. Flashpoint above 20°F
and not over 80°F; or
if the flame extension
is more than 18 inches
long at a distance of
6 inches from the
valve opening.
C. ALL OTHER PRESSURIZED
CONTAINERS
II. Non—Pressurized Containers
A. Flashpoint at or below
20° F.
B. Flashpoint above 20°F
and over 80°F.
C. Flashpoint over 80°F
and not over 150°F.
D. Flashpoint above
150°F.
Extremely flammable.
Contents under pressure.
Keep away from fire, sparks,
and heated surfaces. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat, sparks, and flame. Do
not puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 1 0°F
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces.
Flammable. Keep away from
heat and open flame.
Do not use or store near
heat and open flame.
None required.
-------
Appendix IV—5
STORAGE AND DISPOSAL INSTRUCTIONS FOR PESTICIDES
All products are required to bear specific label instructions
about storage and disposal. Storage and disposal instructions
must be grouped together in the directions for use portion of
the label under the heading STORAGE AND DISPOSAL. Products
intended solely for domestic use need not include the heading
“STORAGE AND DISPOSAL.” The STORAGE AND DISPOSAL heading
must appear in the minimum type size listed below:
Required type size 1
Size of label for the heading
front panel in STORAGE AND DISPOSAL
square inches (all capitals)
10 and under . . . . . . . . . . . . . . .6 point
Above 10 to 15 . . . . . . . . . . . . . .8 point
Above 15 to 30 . . . . . . . . . . . . . 10 point
Over 30. . . . . . . . . . . . . . . . . 12 point
I I
Storage and disposal instructions must be set apart and
clearly distinguishable from other directions for use.
Blocking storage and disposal statements with a solid line is
suggested as a means of increasing their prominence.
A. Storage Instruc i :
All product labels are required to have appropriate storage
instructions. Specific storage instructions are not prescribed.
Each registrant must develop his own storage instructions,
considering, when applicable, the following factors:
1. Conditions of storage that might alter the composition or
usefulness of the pesticide. Examples could be temperature
extremes, excessive moisture or humidity, heat, sunlight,
friction, or contaminating substances or media.
2. Physical requirements of storage which might adversely
affect the container of the product and its ability to
continue to function properly. Requirements might include
positioning of the container in storage, storage or damage
due to stacking, penetration of moisture, and ability to
withstand shock or friction.
3. Specifications for handling the pesticide container,
including movement of container within the storage area,
proper opening and closing procedures (particularly for
opened containers), and measures to minimize exposure
while opening or closing container.
-------
Appendix IV—5
(continued)
4. Instructions on what to do if the container is damaged in
any way, or if the pesticide is leaking or has been
spilled, and precautions to minimize exposure if damage occurs.
5. General precautions concerning locked storage, storage in
original container only, and separation of pesticides
during storage to prevent cross—contamination of other
pesticides, fertilizer, food, and feed.
6. General storage instructions for household products should
emphasize storage in original container and placement in
locked storage areas.
B. Pesticide Disposal Instructions :
The label of all products, except those intended solely for
domestic use, must bear explicit instructions about pesticide
disposal. The statements listed below contain the exact wording
that must appear on the label of these products:
1. The labels of all products, except domestfc use, must
contain the statement, “Do not contaminate water, food,
or feed by storage or disposal.”
2. Except those products intended solely for domestic use,
the labels of all products that contain active ingredients
appearing on the “Acutely Hazardous” Commercial Pestic ide
Products List (RCRA “E” List) at the end of this appendix
or are assigned to Toxicity Category I on the basis of
oral or dermal toxicity, skin or eye irritation potential,
or Toxicity Category I or II on the basis of acute inhala-
tion toxicity must bear the following pesticide disposal
statement:
“Pesticide wastes are acutely hazardous. Improper dis-
posal of excess pesticide, spray mixture, or ririsate is
a violation of Federal Law. If these wastes cannot be
disposed of by use according to label instructions,
contact your State Pesticide or Environmental Control
Agency, or the Hazardous Waste representative at the
nearest EPA Regional Office for guidance.”
The labels of all products, except those intended for
domestic use, containing active or inert ingredients
that appear on the “Toxic” Commercial Pesticide Products
List (RCRA “F” List) at the end of this appendix or
presently meet any of the criteria in Subpart C, 40 CFR
261 for a hazardous waste must bear the following pesticide
disposal statement:
-------
Appendix IV-5
(continued)
“Pesticide wastes are toxic. Improper disposal of excess
pesticide, spray mixture, or rinsate is a violation of
Federal Law. If these wastes cannot be disposed of by
use according to label instructions, contact your State
Pesticide or Environmental Control Agency, or the Hazardous
Waste representative at the nearest EPA Regional Office
for guidance.”
Labels for all other products, except those intended for
domestic use, must bear the following pesticide disposal
statement:
“Wastes resulting from the use of this product may be
disposed of on site or at an approved waste disposal
facility.”
3. Products intended for domestic use only must bear the
following disposal statement: “Securely wrap original
container in several layers of newspaper and discard in
trash.”
C. Container Disposal Instructions
The label of each product must bear container disposaL
instructions appropriate to the type of container.
1. All products intended for domestic use must bear one
of the following container disposal statements:
Container TvDe
Statement
FNon—aerosoi products 1
J(bottles, cans, jars)
Do not reuse container (bottle, can, jar). I
Rinse thoroughly before discarding in trash.
Non—aerosol products
(bags)
Do not reuse bag. Discard bag in trash.
I Aerosol products
I
Replace cap and discard containers in
trash. Do not incinerate or puncture.
2. The labels for all other products must bear container disposal
instructions, based on container type, listed below:
Statement
Container Type
Metal
Triple rinse (or equivalent). Then offer
I
J containers
for recycling or reconditioning, or puncture
I
J(non—aerosol)
and dispose of in a sanitary landfill, or by
j
other procedures approved by state and local
authorities.
Plastic containers
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
I
and dispose of in a sanitary landfill, or
incineration, or, if allowed by state and
local authorities, by burning. If burned,
stay out of smoke.
Glass containers
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved state and local procedures.
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Appendix IV—5
(continued)
C äiüpIétely empty liner by shaking and
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities.
If drum is contaminated and cannot be
reused 1 , dispose of in the same manner.
Paper and
plastic bags
______________________
Completely empty bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning. If burned, stay
out of smoke.
Compressed gas
cylinders
Return empty cylinder for reuse (or
similar wording).
lManufacturer may replace this phrase with one indicating whether
and how fiber drum may be reused.
2. The labels for all other products must bear container
disposal instructions, based on container type, listed
on the first page of this Appendix.
rther drums
with liners
Container Type Statement
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Appendix IV—5
(continued)
Pesticides that are hazardous wastes under 40 CFR 261.33(e) and (f)
when discarded.
“ Acutely Hazardous” Commercial Pesticides (RCRA “E” List)
Active Ingredients, (no inerts) :
Acrolein
Aldicarb
Aidrirt
Allyl alcohol
Aluminum phosphide
4—Aminopyridine
Arsenic acid
Arsenic pentoxide
Arsenic trioxide
Calcium cyanide
Carbon disulfide
p—Chloroanil me
Cyanides (soluble cyanide salts, not specified elsewere)
Cyanogen chloride
2—Cyclohexyl—4 ,6—dinitrophenol
Dieldrin
0,0—Diethyl S—(2—ethylthio)ethylj phosphorodi hioate
(disulfoton, Di—Syston)
0,0—Diethyl 0—pyrazinyl phosphorothioate (Zinophos)
Dimethoate
O,O—Diinethyl O—p—nitrophenyl phosphorothioate (methyl parathion)
4,6—Dinitro—o—cresol and salts
4 ,6—Dinitro—o-cyclohexy].phenol
2,4 Dinitrophenol
Dinoseb
Endosulfan
Endothall
End r in
Famphur
Fluoroacetamide
Heptachior
Hexanethyl tetraphosphate
Hydrocyanic acid
Hydrogen cyanide
Methomyl
alpha—Naphthylthiourea (ANTU)
Nicotine and salts
Octamethylpyrophosphoramide (OMPA, schradan)
Parathion
-------
Appendix P1-5
(continued)
“ Acutely Hazardous” Commercial Pesticides (RCRA “E” List)
Active Ingredients continued :
Phenylmercuric acetate (PMA)
Phorate
Potassium cyanide
Propargyl alcohol
Sodium azide
Sodium cyanide
Sodium fluoroacetate
Strychnine and salts
O,O,O,O—Tetraethyl dithiopyrophosphate (su].fotepp)
Tetraethyl pyrophosphate
Thallium sulfate
Thiofanox
Toxaphene
Warfarin
Zinc phosphide
There are currently no inert ingredients for commercial pesticides
on the “Acutely Hazardous” List (RCRA “E ” List).
-------
Appendix IV—5
(continued)
“ Toxic” Commercial Pesticide Products (RCRA “F” List)
Active Ingredients :
Acetone
Acrylonitrile
Am it role
Benzene
Bis( 2—ethylhexyl)pthalate
Cacodylic acid
Carbon tetrachioride
Chioral (hydrate)
Chiordane (technical)
Chlorobenzene
4—Chloro-m—creso].
Chloroform
o—Chlorophenol
4—Chloro—o—toluidine hydrochloride
Creosote
Cresylic acid
Cyclohexane
Decachlorooctahydro—l,3,4—metheno—2H—cyclobuta [ c,d]_penta len_2_one
(kepone, chlordecone)
1, 2—Dibromo-3—chloropropane (DBCP)
Dibutyl phthalate -
S—3,3—(Dichloroallyl. diisopropylthiocarbamate (dia].late, Avadex)
o—Dichlorobenzene
p—Dichlorobenzene
Dichiorodifluoromethane (Freon 12®)
3 ,5—Dichloro—N—(l,l—dimethy].—2—propynyl) benzamide (pronarnide,Kerb)
Dichioro diphenyl dichioroethane (DOD)
Dichioro diphenyl trichioroethane (DDT)
Dichiorethyl ether
2,4—Dichiorophenoxyacetic, esters and salts (2.4—D)
1, 2—Dichioropropane
l,3—Dichloropropane (Telone)
Dimethyl phthalate
Ethyl acetate
Ethyl 4,4’—dichlorobenzilate (chlorobenzilate)
Ethylene dibromide (EDB)
Ethylene dichioride
Ethylene oxide
Formaldehyde
Furfural
Hexachlorobenzene
Hexachiorocyclopentad iene
Hexachloroe thane
Hydrofluoric acid
-------
Appendix IV—5
(continued)
“ Toxic Commercial pesticide Products (RCRA F” List)
Active Ingredients :
Isobutyl alcohol
Lead acetate
Lindafle
Maleic hydrazide
Mercury
Methyl alcohol
Methyl bromide
Methyl chloride
2,21 —Methyleflebis (3,4,6_trichlOrOPherlOl) (hexachiOrOphene)
Methylene chloride
Methyl ethyl ketone
4_Methyl_2 —Pefltaflofle (methyl isobutyl ketone)
Naphthalene
NitrobeflZefle
p—Ni tropheriol
pentachiorOethafle
pentachlorOflitr0befl2 (PCNB)
pentacloropheflol
phenol
PhosphorOdithiOic acid, 0,0—diethyl, methyl ester
Propylene dichioride
Pyridine
ResorC inol
Saf role
Selenium disulfide
Silvex
1,2 , 4 , 5_TetraChiOrObefizene
1, 1,2 , 2_TetrachiOroethafle
TetrachioroethY lene
2 , 3 , 4, 6_TetraChlOropheflol
Thiram
Toluefle
1,1, 1_TrichiOroethafle
TrichlOrOethYlefle
Trich1OrOmOflOf1U0r0 t 1 (Freon ll)
2,4, 5_TrichlOrOpheflol
2,4 ,6_TrichlOrOPheflol
2,4,5_TrichlOrOPheflOXYaC5t acid (2,4,5T)
Xy 1 e ne
-------
Appendix IV—5
(continued)
UToxicft Commercial Pesticide Products (RCRA “F” List)
Inert Ingredients :
Acetone Formaldehyde
Acetonjtrj le Formic acid
Acetophenone Isobutyl alcohol
Acrylic acid Meleic anhydride
Aniline Methyl alcohol (methanol)
Benzene Methyl ethyl ketone
Chlorobenzene Methyl methacrylate
Chloroform Naphthalene
Cyclohexane Saccharin and salts
Cyclohexanone Thiourea
Dichlorodjfluoromethane (Freon 12®) Toluene
Diethyl phthalate l,l,l—Trichloroethane
Dimethylamine 1,1, 2—Trichioroethane
Dimethyl phthalate Trichiorofluoromethane (Freon li®)
1,4—Dioxane Vinyl chloride
Ethylene oxide Xylene
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