United State*
Environmental Protection
Agency
Office of Pectlddes and Toxte Sufaeuneae
Office of Pectidde Pragramt (TS-766C)
Wmhlngton, DC 20460
vvEPA
Pesticide
Fact Sheet
Name of Chemical: AT. mi-IE
Reason for Issuance:
Date Issued: oe/30/83
Fact'Sheet Number:
1. Description of the chemical
Generic name: Aluminum Tris (O-ethyl phosphonate)
Common name: Fosetyl-Al
Trade name: Aliette
EPA Shaughnessy code: 123301
Chemical Abstracts Service (CAS) number: 39148-24-8
Year of initial registration: 1983
Pesticide type: fungicide
Chemical family: Aluminum ester of alkyl phosphonates
U.S. and foreign producers: Rhone-Poulenc, Incorporated
2. Use patterns and formulations
0 Application sites: Greenhouses, field grown ornamentals,
and pineapple seed pieces
• Types of formulations: Nettable power
0 Types and Metnods of applications: Dip and ground spray
apparatus
* Usual carriers: water
3. Science Findings
Summary science statement: There are no extensive data gaps
that exist for Fosetyl-Al. The toxicity from oral, dermal,
and inhalation route of exposure is low. The chemical has
been demonstrated to be a stong eye irritant. The chemical
is considered to be an oncogen. Available data indicate that
Fosetyl-Al has no teratogenic potential nor is it a mutagen.
Fosetyl-Al is degradated rapidly in both moist and dry soils
under aerobic conditions, with half-lives 1 to 1/2 half hours
and 20 minutes respectively. The chemical is not expected to
contaminate groundwater.
Fosetyl-Al has a low toxicity for both fisn and wildlife, ana
the chemical and its use patterns presents no problems to
endangered species.
Chemical characteristics:
0 Fosetyl-Al is a fine white, odorless powder. It is stable to
heat, melts with decomposition at temperatures greater than
200° C. The chemical does not present any unusual handling
hazards.
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Toxicological characteristics:
• Fosetyl—A1 is considered a strong eye irritant (Toxicity
Category I).
• It demonstrates low toxicity from oral, dermal and irthala—
tion routes of exposure (Toxicity Category IV, III, & III
respectively).
• The chemical is not considered to be a skin irritant.
° Toxicology studies on Posetyl—Al are as follows:
— Oral LD5 O in rats: 5.4 gm/kg body weight
— Dermal LE in rats: >3 gm/kg
— Inhalation Lc51, in rats: >1.73 ag/ i
— Eye Irritation in rabbits: 2/6 animals revealed pannus
of the cornesa at 7 days and continued to show irritat-
ing effects at 21 days
— Dermal Irritation in rabbits: not an irritant
— Skin Sensitization in guinea pigs: Not a skin sensitizer
— Teratology in rabbits: No observeable effect level (NOEL)
> than 500 mg/kg/day
— Teratology in rats: NOEL ) than 1000 mg/kg/day
— Multigeneration Reproduction study in rats: The repro-
duction NOEL is 6000 parts per million (PPM); the
lowest effect level (tEL) is 12,000 ppm (crystalline
deposits in urogenital system, lower overall weight
gains in the 2b generation, lower litter and mean
pup weights in late lactation)
— Chronic feeding/oncogenicity in rats: The chronic
feeding/ oncogenicity NOEL is 8000 ppm; the LEt is
3000/4000 ppm (calculi and mineralization in 14/79
males in urogenital)
— Chronic feeding in dogs: The chronic feeding NOEL is
10,000 ppm; the tEL is 20,000 ppm (presence of sperma-
tocytic and or spermatidic giant cells within the
semineferous tubules).
— Oncogenicity in mice: No oncogenic effects were induced
at any dose level under conditions of this test (highest
dose tested 20,000/30,000 ppm).
— Mutagenicity: Fosetyl—Al did not show any mutagenic
activity in gene mutation, chromosomal aberration, or
micronucleus tests.
Environmental Characteristics:
° The degradation of Fosetyl—Al in soil under aerobic
conditions is quite rapid and is due to microbial
action. Half—life is 1 to 1/2 hours in loamy sand,
silt loam, and clay loam soils, and 20 minutes in
sandy loam soil. The degradation proceeds through
the hydrolysis of the ethyl ester bonG resulting in
the formation of phosphorous acid and ethanol.. The
ethanol is further degraded into carbon dioxide. The
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phosphorous acid formed will form precipitates with
calcium, aluminum, or iron in the soil or with aluminum
from the Fosetyl—Al.
• Under field conditions, the chemical is not expected
to leach.
• Bioaccumulation does not appear to be a factor.
• The use patterns are not expected to result in direct
contamination hazards (via spray drift) to humans,
livestock, or wildlife outside the application sites.
Ecological characteristics
• Avian oral LD 50 : >8000 mg/kg (extremely low toxicity)
• Avian dietary LC z >20,000 p
• Fish L O: >150 ag/l (low toxicity)
• Aquatic invertebrate LC : 189 ppm
‘ The use patterns of the chemical do not presenL any
problem to endangered species.
Tolerance assessment
• A tolerance of 0.1 ppm is required for pineapples and
pineapple forage. Data developed with C ’ 4 labeled Fosety-
Al indicate that residues of Fosetyl-Al or its metabo-
lites could remain in harvestea pineapples at or below
the level of analytical method detection.
4. Summary of Regulatory Position and Rationale
• General Use
• No use, formulation, or geographical restrictions are
required
o Because of oncogenicity potential of this compound a
risk assessment was calculated for all uses involved.
The risk calculations are based on overestimates of any
actual risk exposure. The calculated risks, although
low, are likely to be overestimates.
• Dietary risk for pineapples is 0.27—2.40 X 10—8
• Oncogenic risk exposure ranged from 1.0—9.0 x io —9
to applicators to 0.7—6.0 X 10-6 for pineapple planters
wearing gloves.
°• For the pineapple use, the foi1owin j statement is re-
quired to reduce the exposure to seed piece planters:
Note to User : Gloves impermeable to Fosetyl—A.l must
be worn during the handling and planting of pineapple
crowns (seed pieces).
5. Summary of Major Data Gaps :
• Exposure monitoring study for pineapple seed piece
treaters.
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6. Contact person at EPA
Sönry . 7acoby
EPA (TS-767—C)
401 M St., S.W.
Washington, D.C.20460
Phone (703) 557—1900
DISCLAIMER: The inforaation presented in this Cfle icaj.
InforRation Pact Sheet is for inforaational purposes only
and Rb not be uSed to fulfill data require .nt, tor
pesticide registration and reregistration.
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