United Stctai Offlot of Ptrtlddw and Toxic Sutttanon
Environmental Protection OfflM of Pestidd* Program* (TS-766C)
Agency Waning ton, DC 20460
Pesticide
Fact Sheet
Name of Chemical: ANIEAZINE
Reason for Issuance:
Date Issued: December 16, 1983
Fact Sheet Number:
12
1. Description of Chemical;
Generic none: 2,4-dichloro-6-(O-chloroanilino)-&-triazine
Cannon rune: Anilazine
Trade nones: Dyrene, Direz, Kemate, Triasyn, B-622, Ent-26,058, HC1-O06684,
4,6-Klichloro-N-(2-chloraphenyl)-l,3,S-tria2in-2-«nine.
EPA Shaughnessy Code: 080811
Chemical Abstracts Service (CAS) amber: 101-05-3
year of intitial registration: 1957
Pesticide type: fungicide
Chemical family: triazine
U.S. and foreign producers: Nobay Chemical Corporation
2. Use Patterns and Formulations;
Application sites: turf, tobacco, ornamentals, various fruits and vegetables
Types of formulations: dust, vettable powder, granular
Types and methods of application: foliar application, additive to vinyl
plastics
Application rates: 1.0 to 3.0 Ib active ingredient per acre
Usual carriers: water
3. Science Findings;
Suonary science statement:
Extensive data gaps exist for Anilazine. NO human toxioological
hazards of concern have been identified in studies reviewed by the
Agency for the standard. The Agency has no information that indicates
continued use will result in any unreasonable adverse effects to nan
or his environment during the time required to develop the data.
Chemical characteristics:
Anilazine is a white to tan crystalline solid, it is stable in
neutral to slightly acidic media and subject to hydrolysis, it
has a melting point of 159-160 C. The chemical does not present
any unusual handling hazards.
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loxi l ica.1 characteristi :
nilazine is considered a skin sensitizer. It daionstrates.
l i toxicity fran oral routes of exposure. The che!nical has been
found to be highly toxic to fish and aquatic invertebrates.
Aoute toxi 1ogy results:
( al L [ o in rats: 2.71 g/kg body ighb (28—33 days)
(lox Category III)
CEal LD 50 in rabbits: 460 nv/kg (lox Category II)
oral L [ 0 in dogs: MID> 7.1 g/kg (lOX Category IV)
Oral LI in no*eys: MID> 3.2 g/kg (lox Category III)
Dennal LJ in rabbits: > 9.4 g/kg (intact skin)
(lox Category III) > 2.5 g/kg (abraded skin)
E e irritation in rabbits: Cbrneal c acity in 3/6 animals,
iris irritation, redness, ch wsis which persisted through
day 21 (lox Category I)
thronic toxicology results:
Rat and nouse on enicity st*.dies re negative at dosE
levels tested (500 and 1000 ppn). Clinical toxic signs
re noted at both doses in second year.
Major routes of exposure:
dennal
Envirorlrental tharacteristic :
Micrabial breakd :
Anhlazine is degraded rapidly in both noist and dry soils under
aerobic conditions, with half—lives of 0.5 and 2.5 days, respec-
t ive ly.
Msorption and leaching in basic soil types:
Milazine is classified to be of internediate nobility in a
sandy loan and of l nobility in agricultural sand, sandy clay
loan, silt loan and silty clay soils based on soil TLC.
Ecological characteristi :
Hazarde to fish and wildlife:
Avian dietary LC 50 : Anilazire did not cause 50% nortaiity
when birde re exposed to a diet
containing 5000 ppn for > 10 to
(100 days.
Avian oral L 0 : > 2,000 mg/kg
Fish i L : 50 : 0.14 to 0.326 pçin (highly toxic)
uatic invertebrate LC : 0.270 pçxn (highly toxic)
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7blerance asseS flt:
D. tO the abeence of pertinent data, the agency is unable to
cciip1et its reasaes nt of anilazirie tolerances.
List of present tolerances:
op
Blac berries 10.0
BlueberrieS 10.0
celery 10.0
anberries 10.0
O c bers, including pidiles 10.0
De erries 10.0
Garlic 1.0
Cmions, dry bulb 1.0
ions, green 10.0
Potatoes 1.0
pr lu k to have ocoirred trc* use:
The pesticide Incident nitoring Systan (PIlLS) includes a report of
dennatitis and delayed dennal hypersensitivity in several laborers hanc
harwst.trig. anilazine treated stra erries and tcm toes in 1 nnessee. With
trea nt, re zy required at least one ek, bot s tai reaarred with
increased severity upon re-.e oeure.
4 91Tr y of J gulatory Position and Rationale :
use Classification: General
Unique label rning stat nts:
All proc ct labeling is required to bear the statarent protective
clothing shc*ild be rn during perioth of exposure, sucth as, during
application or when contacting treated foliage..
Mar*ifacturing-use labels nust contath the stat nts This pesticide
is toxic to fish and aquatic invertebrates. Do r t discnarge into
lakes, stre , ponde or pt 1ic ter unless in a rdance with an
NP S permit. For guidance, contact y ir I gionaI Office of EPA.
All end-use labels, except t x e for use on cranberries, nust contain
the statw nts This pesticide is toxic to fish anc aquatic
invertebrates. Do r t apply directly to ter or tlands. itt and
runoff tr in treated areas may be hazardc js to aquatic or ania in
neigttoring areas. Do r t cont ninate ter by cleaning of equi nt or
disposal of stes.
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All end-use iabela for use on cranberries mist oontain the stata nte
Th1a pesticide is toxic to fish and aquatic invertebrates, PIv ient
fr treated areas may be hasar ia to aquatic organiazie in neigh-
ring areas • r cont ninate ter by cleaning of equipient or
diepcieal of stes. ’
All end-use labels mist oontain the follo,ing stat nts:
‘tr, not use on seed cr intended to be used for feed or fora3e. 1x
not graze treated areas.
‘rx) not reenter treated fields within 24 t urs toll ,ing application
of this product.’
5• 9. vn*ry of major data gkpe :
product O Tastry (Die Au t 1984)
pr’o jct identity
Analysis and certification of proc ict ingredients.
P ysical and th nica1 tharacteristics
i si&e thenistry (Die June 1986)
Nat e of resickie and analytical mathod for plants and animal residues
Stora stability data
q field trials on all cr s except ai trters, sLiTr r squash,
deidsrries, loganberries, and raspberries
procsaaed food/feed studies on potatoes and taia toes
D virori nta1 Fate (Die 1 ca ter 1987)
i dro1ysis
photodegradat ion
Metabolien studies
M3bility studies
Soil and aquatic dissipation studies
j il at ion studies
Toxi logy (Die Decenber 1987)
1J**alatian LC — rat
21—day dermal
90-day deni 1 (vinyl widitive use only)
90-day inhalation - rat
Ø%rcnic toxicity - rodent and r —rodent
mratogenicity - 2 species
Mprock lcti ofl — 2 generation
*ita nicity testing
General uQtabolien
.ntry protection (Die De er 1987)
Foliar dissipation
e osure
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wjldljfe and k]uatiC gariIw (DJe De ber 1987)
AviSfl orl I D 50
Avian dietary LC50 - upland g bira an tert w1
ita LCSO — fre&amter invertebrates
pjst early life stage and aquatic invertebrate lite—cycle -
invertebrate and fish
6. t reon at EPA :
Henry P1. JaCoby
EPA (TS-767C)
401 P1. St., S.W.
ahjzigtai , D.C. 20460
Pt n (703) 557—1900
DISClAIMER: The infoniation presented in this a uical Information Fact
eet is for informational purp es onLy and may r t be used to tuif ill
data requir nts for pesticide registration and reregistration.
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