United StttH OHIco of PMtlckta «nd Toxic Envlronmantal Protection office of Panted* Programs (TS-766C) Agency WHhington, DC 20460 xe/EPA Pesticide Fact Sheet Name of Chemical: ARSENAL Reason for Issuance: Amended following industry review Date Issued: 09/05/35 Fact'Sheet Number: 63 1. Description of Chemical Code Names: Cl 243,997 and PC 243,997 EPA Shaughnessy Code: 128821 Chemical Abstracts Service (CAS) Nunber: 81334-34-1 Year of Initial Registration: 1984 Pesticide Type: Herbicide Chemical Family: Dnldazolinone U.S. and Foreign Producers: American Cyanamld Company 2. Use Patterns and Formulations Application sites: Noncropland areas such as railroad, utility and pipeline rlghts-of-way, utility plant sites, petroleum tank faros, pumping Installations, fence rows, storage areas, nonlrrlgatlon dltchbanks and other similar areas. Types of formulations: Aqueous solution of isopropylamlne salt Types and methods of application: End-use product may be applied either pre-emergence or postemergence to the weeds. In most situations, the preferred method is postemergence application. Product Is mixed with water and applied as a spray. Application rates: 0.5 to 1.5 Ibs. acid equivalent per acre depending on weed species and degree of Infestation. Usual carriers: Water. Drift control agent and foam reducing agent may be added if needed. ------- —2— 3. Science Findi gs Sunniary science stateiient: Results of acute toxicity 8t ie8 indicate toxicity category III. Chronic sti. iies present no evidence of ziacceptab1e health hazards resulting fran jropo8ed e. Ecolcgica]. effects data ir icate that the tech iical acid is practically nontoxic to avian and aquatic organ1 n8. Additional fish and wildlife 8tudies are required, on the salt fonnulation. Several data gape exist in &ivirorinental fate. Chenical characteristics: Physical state: Color: Po der I* iite to off—white () or: Slight acetic acid odor Meltir€ point: 169—173°C &ilk densIty: 13.1 lb/cubic foot Solubility: 1.0 to 1.5% In water at 25°C Dissociation constant: pk 1 =1.9, pk 2 =3.6 0ctarioiJ%* ter partition coeffIcient: 1.3 greater than 5,000 irgJlcg Toxicity category III Acute derrnal toxicity (rabbit): greater than 2,000 ngJlcg Toxicity category III Primary eye irritatIon (rabbit): Toxicity category III PrImary sld.n irritation (rabbit): ‘lbxicity category P1 pH: Stability: Toxicolcgy characteristics: Acute toxicolcgy results: Acute oral toxicity (rat): 3-3.5 as 1% solution in water at 25°C Stable at 25°C for at least 18 n nths ------- —3— Acute inhalation toxicity (rat): greater than 5.1 nRJl (runlnal) greater than 1.3 mg/i (gravimetric) ¶I xIcity category III Dennal sensitization (guinea pig): Technical materIal 18 not a sld.n sensitizer. Chronic toxicoic y results: 21-day derina]. (rabbit): Systamic 1 DEL is 1400 ng/kgJday (HEIr). The for sldn is 1100 mg/kg/day (HDF). Teratolc€y (albino rat): M)EL for teratogenicity and fetotoxicity Is 1,000 mgJkgJday. fl !X) for maternal toxicity is 300 mg/kg/day. The LEL Is 1,000 mg/kgJd&y with salivation occurring In 6 of 22 fanales. Teratology (albino rabbit): Test material .s not teratogenic or fetotoxic at dosages up to 1400 mg/kg/day (HEIr). The maternal toxic }DEL is 1100 mg/kg/day. Mitagenicity: Technical material s not mutagenic In the nes assay. Metabolism (rat): The half-life of the technical s less than one day. re s no significant radiolabeled cançoizid detected in tissue residues. Major routes of expo8ure: Mixers, loaders and applicators would be expected to receive the most exposure via skin contact and inhalation. ThysIoic Ical and blocheinica ] . behavioral characteristics: Follar absorptiai: The product is absorbed by roots and foliage. Translocation: The product translocates readily following absorption and is dlstrthuted between roots and foliage. Mechaniam of pesticidal action: ¶fl herbicide prevents the production of the amino acids; valine, leucine and isoleucine. Once the levels of these amino acids decrease, protein synthesis slows do ’ni and growth stops. The growing points of target plants die first. Mature, green tissue is not as rapidly affected. Envirorinental characteristIcs: Adsorption and leaching In basic soil types: The technical material has a moderate leaching potential. The adsorption coefficient (K) ranges fran 1.7 in a clay loam soil (14.6% organic matter) to 11.9 a a silt loam soil (14.0% organic matter). The adsorbed material will desorb fran soil. ------- Loss fr rI todecanposition: chriical material will hotodegr&2e in aq .eous solution with a hall—life of 2.5 to 5.3 days (12 hours of aui].lght/day). Ecolc€ica]. characteristics: Fish acute toxicity (Rainbow trout): greater than 100 nRJl Fish acute toxicity (Bluegill sunfish): greater than 100 mg/i Fish acute toxicity (Channel catfish): greater than 100 rrgJl Aquatic invertebrate toxicity ( Daphnia ma a) : greater than 100 mg/i Avian acute oral toxicity (Bobwhite quail): greater than 2,150 mg/kg Avian acute oral toxicity (Mallard ducks): greater than 2,150 mg/kg Avian dietary toxicity (Bobwhite quail): greater than 5,000 p n Av an dietary toxicity (Mallard ducklir€s): greater than 5,000 ppn L . &m n ry of’ Regulatory Position and Rationale : Use, formulation, manufacturing process or gec raphical restrictions: Do not use on food or feed crops • Do not apply to ditches used to transport Irrigation water. Do not apply where runoff water may flow onto agricultural land as injury to crops may result. Keep fran contact with fertilizers, insecticides, fungicides and seeds. Do not apply or drain or fh h equiçxn&it on or near desirable trees or other plants, or on areas where theIr roots may exterxl, or in locations where the ch nical may be washed or moved into contact with their roots • Do not use on lawns, walks, driveways, tennis courts, or similar areas. Prevait drift of spray to desirable plants. Do not use In California. Unique label warning stat n its: PHYSICAL AN]) CH 14ICAL HAZARDS Spray solutions of’ Arsenal should be mixed, stored and applied only in stainless steel, fiberglass, plastic and plastic-lined containers • Do not mix, store or apply Arsenal or spray solutions of Ars al in unlined steel (except stainless steel) containers or spray tanks. ------- —5— 5. Si .r y of !. jor Data Gaps : Ecological Effects: The following studies are to be done with the end-use product: Avian single—dose oral Lt 0 (1 teat) Avian dietary LC 50 (2 tests - waterfowl and upland game bird) Acute toxicity test for freshwater fish (2 tests - warm water and cold water species) Acute toxicity test for freshwater aquatic invertebrates (1 test) A waiver of above studies will be considered If data are supplied that fulfill: one avian dietary study, one freshwater fish study, an aquatic invertebrate study and demonstrate equivalent toxicity levels to the technical material. &ivirczinental Fate: Mnguideline 8tudy - Application of’ 11 C Arsenal to weeds Fish acctmulation study Field dissipation study (if field crop uses are proposed in the future) 6. Contact Person at EPA : Robert J. Taylor Product Manager (25), —767C &iviror nental Protection Agency i0l M Street, S.W. Washington, D.C. 201460 Phor : (703) 557—1800 DISCLATh1 : Information presented in this Pesticide Fact ieet Is for informational purposes only and may not be used to ThlfIll data requirements for pesticide registration and reregistration. ------- |