United StttH            OHIco of PMtlckta «nd Toxic
                     Envlronmantal Protection      office of Panted* Programs (TS-766C)
                     Agency                WHhington, DC 20460
  xe/EPA      Pesticide
                     Fact  Sheet
                     Name of Chemical:  ARSENAL
                     Reason for Issuance: Amended following industry review
                     Date Issued:     09/05/35
                     Fact'Sheet Number:
1.   Description of Chemical
     Code Names: Cl 243,997 and PC 243,997
     EPA Shaughnessy Code:   128821
     Chemical Abstracts Service (CAS) Nunber:  81334-34-1
     Year of Initial Registration:  1984
     Pesticide Type:  Herbicide
     Chemical Family:  Dnldazolinone
     U.S. and Foreign Producers:  American Cyanamld  Company
2.   Use Patterns and Formulations
     Application sites:  Noncropland areas such as railroad, utility and
       pipeline rlghts-of-way, utility plant sites, petroleum tank faros,
       pumping Installations, fence rows, storage areas, nonlrrlgatlon
       dltchbanks and other similar areas.
     Types of formulations:   Aqueous solution of isopropylamlne salt
     Types and methods of application: End-use product may be applied either
       pre-emergence or postemergence to the weeds. In most situations, the
       preferred method is  postemergence application.  Product Is mixed with
       water and applied as a spray.
     Application rates:  0.5 to 1.5 Ibs. acid equivalent per acre depending on
       weed species and degree of Infestation.
     Usual carriers:  Water. Drift control agent and foam reducing agent may
       be added if needed.

3. Science Findi gs
Sunniary science stateiient: Results of acute toxicity 8t ie8 indicate
toxicity category III. Chronic sti. iies present no evidence of
ziacceptab1e health hazards resulting fran jropo8ed e. Ecolcgica].
effects data ir icate that the tech iical acid is practically nontoxic
to avian and aquatic organ1 n8. Additional fish and wildlife 8tudies
are required, on the salt fonnulation. Several data gape exist in
&ivirorinental fate.
Chenical characteristics:
Physical state:
Po der
I* iite to off—white
() or: Slight acetic acid odor
Meltir€ point: 169—173°C
&ilk densIty: 13.1 lb/cubic foot
Solubility: 1.0 to 1.5% In water at 25°C
Dissociation constant: pk 1 =1.9, pk 2 =3.6
0ctarioiJ%* ter partition coeffIcient: 1.3
greater than 5,000 irgJlcg
Toxicity category III
Acute derrnal toxicity (rabbit): greater than 2,000 ngJlcg
Toxicity category III
Primary eye irritatIon (rabbit): Toxicity category III
PrImary sld.n irritation (rabbit): ‘lbxicity category P1
Toxicolcgy characteristics:
Acute toxicolcgy results:
Acute oral toxicity (rat):
3-3.5 as 1% solution in water
at 25°C
Stable at 25°C for at least 18 n nths

Acute inhalation toxicity (rat): greater than 5.1 nRJl (runlnal)
greater than 1.3 mg/i (gravimetric)
¶I xIcity category III
Dennal sensitization (guinea pig): Technical materIal 18 not a
sld.n sensitizer.
Chronic toxicoic y results:
21-day derina]. (rabbit): Systamic 1 DEL is 1400 ng/kgJday (HEIr). The
for sldn is 1100 mg/kg/day (HDF).
Teratolc€y (albino rat): M)EL for teratogenicity and fetotoxicity
Is 1,000 mgJkgJday. fl !X) for maternal toxicity is 300 mg/kg/day.
The LEL Is 1,000 mg/kgJd&y with salivation occurring In 6 of
22 fanales.
Teratology (albino rabbit): Test material .s not teratogenic or
fetotoxic at dosages up to 1400 mg/kg/day (HEIr). The maternal
toxic }DEL is 1100 mg/kg/day.
Mitagenicity: Technical material s not mutagenic In the nes assay.
Metabolism (rat): The half-life of the technical s less than one
day. re s no significant radiolabeled cançoizid detected in
tissue residues.
Major routes of expo8ure: Mixers, loaders and applicators would be
expected to receive the most exposure via skin contact and inhalation.
ThysIoic Ical and blocheinica ] . behavioral characteristics:
Follar absorptiai: The product is absorbed by roots and foliage.
Translocation: The product translocates readily following
absorption and is dlstrthuted between roots and foliage.
Mechaniam of pesticidal action: ¶fl herbicide prevents the production
of the amino acids; valine, leucine and isoleucine. Once the
levels of these amino acids decrease, protein synthesis slows do ’ni
and growth stops. The growing points of target plants die first.
Mature, green tissue is not as rapidly affected.
Envirorinental characteristIcs:
Adsorption and leaching In basic soil types: The technical material has
a moderate leaching potential. The adsorption coefficient (K) ranges
fran 1.7 in a clay loam soil (14.6% organic matter) to 11.9 a a
silt loam soil (14.0% organic matter). The adsorbed material will
desorb fran soil.

Loss fr rI todecanposition: chriical material will hotodegr&2e in
aq .eous solution with a hall—life of 2.5 to 5.3 days (12 hours of
Ecolc€ica]. characteristics:
Fish acute toxicity (Rainbow trout): greater than 100 nRJl
Fish acute toxicity (Bluegill sunfish): greater than 100 mg/i
Fish acute toxicity (Channel catfish): greater than 100 rrgJl
Aquatic invertebrate toxicity ( Daphnia ma a) : greater than 100 mg/i
Avian acute oral toxicity (Bobwhite quail): greater than 2,150 mg/kg
Avian acute oral toxicity (Mallard ducks): greater than 2,150 mg/kg
Avian dietary toxicity (Bobwhite quail): greater than 5,000 p n
Av an dietary toxicity (Mallard ducklir€s): greater than 5,000 ppn
L . &m n ry of’ Regulatory Position and Rationale :
Use, formulation, manufacturing process or gec raphical restrictions:
Do not use on food or feed crops • Do not apply to ditches used to
transport Irrigation water. Do not apply where runoff water may
flow onto agricultural land as injury to crops may result. Keep
fran contact with fertilizers, insecticides, fungicides and seeds.
Do not apply or drain or fh h equiçxn&it on or near desirable trees
or other plants, or on areas where theIr roots may exterxl, or in
locations where the ch nical may be washed or moved into contact
with their roots • Do not use on lawns, walks, driveways, tennis
courts, or similar areas. Prevait drift of spray to desirable
plants. Do not use In California.
Unique label warning stat n its:
Spray solutions of’ Arsenal should be mixed, stored and applied
only in stainless steel, fiberglass, plastic and plastic-lined
containers • Do not mix, store or apply Arsenal or spray
solutions of Ars al in unlined steel (except stainless steel)
containers or spray tanks.

5. Si .r y of !. jor Data Gaps :
Ecological Effects:
The following studies are to be done with the end-use product:
Avian single—dose oral Lt 0 (1 teat)
Avian dietary LC 50 (2 tests - waterfowl and upland game bird)
Acute toxicity test for freshwater fish (2 tests - warm water
and cold water species)
Acute toxicity test for freshwater aquatic invertebrates (1 test)
A waiver of above studies will be considered If data are supplied
that fulfill: one avian dietary study, one freshwater fish study,
an aquatic invertebrate study and demonstrate equivalent toxicity
levels to the technical material.
&ivirczinental Fate:
Mnguideline 8tudy - Application of’ 11 C Arsenal to weeds
Fish acctmulation study
Field dissipation study (if field crop uses are proposed in the future)
6. Contact Person at EPA :
Robert J. Taylor
Product Manager (25), —767C
&iviror nental Protection Agency
i0l M Street, S.W.
Washington, D.C. 201460
Phor : (703) 557—1800
DISCLATh1 : Information presented in this Pesticide Fact ieet Is for
informational purposes only and may not be used to ThlfIll data requirements
for pesticide registration and reregistration.