United Stttv Office of Pesticides and Toxic Sutastinces Environmental Protection office of Past tad* Programs (TS-766C) Agency Washington, DC 20460 oEPA Pesticide Fact Sheet Name of Chemical: BRONOPOL Reason for Issuance: Date Issued: August 2, 1984 Fact Sheet Number: 1. Description of Chemical Generic Name: 2-Brono-2-nltropropane-l,3-diol Common Name: Bronopol - Boots Trade Name: Myaclde BIO, Myacide AS EPA Shaughnessy Code: 216400 Chemical Abstracts Service (CAS) number: 52-51-7 Year of Initial registration: Aufrust 2, 1984 (EPA Reg. No. 33753-1; MUP) Pesticide Type: Bacterlclde Chemical Family: Alcohol Producers: U.S. none Foreign The Boots Co., PLC 2. Dse Patterns and Formulations Application Sites: pesticide manufacterlng facilities. Types of Formulations: crystalline powder Types and Methods of application: the only registration is for manufac- turing use only. N/A Application rates: N/A Usual carriers: water 3. Science Findings Chemical Characteristics: Physical state: white crystalline powder Melting point: approz. 130°C Bulk density: 1.10 mg/ml Solubility: in ethanol 50Z in water (25°C) 25Z in ethylene glycol 61Z In chloroform 0.9Z ------- Toxicity Characteristjc : Study Effects Catagorv Eye Irritation 5% solution strongly irritating . I Skin Irritation .............. a severe irritant .................. I Dermal LD 50 ................... not specified .. ••••..••.... I Oral LD 50 (mg/kg): ..... II orally administered....... male 307 & female 342 (rat) male 374 & female 327 (mouse) intraperitoneal ........... male 22.0 & female 30.2 (rat) male 22.8 & female 34.7 (mouse) Inhalation ‘ 50 •.............. LC 50 > 5 mg/L ..................... III Dermal Sensitization ...............not a akin sensitizer 90 day Oral (rat) .......... no observable effect level: 20 mg/kg/day lowest effect level: 80 mg/kg/day Teratology ................. no observable effect level: 3.3 mg/kg/day (rabbit) lowest effect level: 10 mg/kg/day Physiological and Biochemical Behavioral Characteristics: Foliar absorption: N/A Translocation: N/A Mechanism of pesticidal action: N/A Metabolism and persistence in plants and animals: N/A Environmental Characteristics: Adsorption and leaching basic soil types: N/A Microbial breakdown: N/A Hydrolysis: bronopol appears to hydrolyze slowly at acidic or neutral pH conditiona. Bronopol decomposes in aqueous solution on exposure to light. Increases in temperature increases de- composition. Label required to disallow any pesticide waste discharge into aquatic environments. Bioaccumulation: N/A Ecological Characteristics: Mallard duck Acute Oral LD 50 510 mg/kg Fresh Water Invertebrate ( Daphnia ) 48 hr EC 50 — 1.4 mg/L Efficacy Data: N/A Tolerance assessments: N/A, no crop applications. Problems which are known to have occurred with use of the chemical (e.g., PD(S): none 4. Sunm ary of Regulatory Position and Rationale : Use Classification: General Use Use, formulation, manufacturing process or geographical restrictions: do not discharge into aquatic environments unless In accordance with and NPDES permit. ------- 3 Unicue warning statements required of labels: none Su ary of risk/benefit review: none, risk assessment was not conductec. 5. Suary of malor data gaps The following studies are to aub itted by December 13, 1984: a. Avian Acute LC 50 b. Fish Acute LC 50 (Rainbow trout) 6. Contact person at EPA : John B. Lee, Product Manager 31 Disinfectante Branch Registration Division (TS—767C) Tel. (703) — 557—3675 DISCLAD R:The information presented in this Chemical Information Fact Sheet is for informational purposes only and may not be used to fulfil data re- quirements for pesticide registration and reregistration. ------- WKR1I&1 I(lt W 11It, i. - ItXJTeJ U*.I al sg 1 y i aL Pri * rt& Ii i. a violation of Po ral La. to t II$I. wud ..t in a i caiai.t.’i( Saul its Iato1I1l . l’ur a L sutacIuI r5 in tonsilstIn du.ksf.ctsnts, ssaltiocru, aI r tIv . gatorw this piod t as. r .ibi. far 1a1ai* W* rI tr t& tar U1r to. dat praxlw,t s for ovidi I r rtats ta. I! I Mm D1I *L — lb oct coctLMt. tsr fo I or f d ‘v stor or dt t . kl*ip ma hsst. I si1ei astm Ill scuisly has a. l a’ r dispasi a.f p 1iotds. np status.. 1w rI ta I a a vtoLatt of rsi La ,. 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BEST DOCUMENT AV!UUU3LE 9 luculsr light . 1Iubi lll y is Valor ( Ct Is lilanol 1. ItIiylww ulycol is Qiionsf ais v/v ,t v/v et .e. 0.9% a/v bilk ity bit ulta is 1 Ilipebcal tmI 4, ------- |