United States Office of Pesticides and Toxic Subrtances
Environmental Protection Office of Pesticide Programs (TS-766CI
Agency Washington. DC 2O460
&EPA Pesticide
Fact Sheet
Name of Chemical: BUTYIATE
Reason for Issuance:
Date Issued: March 22, 1984
Fact Sheet Number: 7
1. Description of chemical;
Generic Naae: Butylate
COODOD name: butylate
Trade name: Sutan
EPA Shaughneusy Code: 041405
Chemical Abstracts Service (CAS) Number: 2008-41-5
Tear of Initial Registration: 1967
Pesticide Type: Herbicide
Chemical family: Thlocarbanate
U.S. and Foreign Producers: Stauffer Chemical Company, PPC Industries, Inc.
2. Use patterns and formulations:
Application sices: Sweet corn, field corn, and popcorn
Types of formulations: Granulars, emulsiflable concentrates, and encapsulated
Types and Methods of Application: Soil Incorporation, generally with discs or
hooded powerdriven tillers, often in combination with atrazlne and/or cyana-
zine herbicide. Center pivot irrigation systems can be used in some areas.
Application Rates: 3.4- 6.7 Ibs ai/A
Usual carriers: Emulsifiable liquid formulations are diluted in water.
3. Science Findings;
Summary science statement:
Butylate appears to pose few, If any, acute toxlcologlcal hazards to
huaans or non-target wildlife. The only major concern is the lack of
Inhalation toxlclty data. Such data has been requested In the standard.
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Chemical characteristics:
Physical state: Liquid
Color: Yellow to ber
Odor: Mine
Boiling point: 71. C at 10 ma Hg
Nelting point: Not applicable
Flash point: (TOC) 110C
Unusual. handling characteri. t ice: None • Non—corrosive, stable
at normal ambient tampa.
Toxicological characteristics:
Acute Effects:
Acute Oral LD 50 — Low — (Tox Category III) (3.0 g/kg)
Acute Dermal LD 50 — Low — (Tox Category III) (>2 glkg)
Dermal Irritation — Not an irritant
Acute Inh*lation Toxicity — data gap
Primary Eye Irritation — Caused permanent ai age in 1/6 of unwashed eyes
(Tox Category II)
Chronic Effects:
Oncogenicity — No dose—related effects at levels up to 320 mg/kg/day (EDT)
(Highest Dose Tested) in a 24—month study.
Teratology — No effects at up to 24 ag/kg (EDT).
Reproductive Effects — No effects at up to 24 mg/kg (EDT).
Mutagenicity — data gap
Feeding Studies — 13—week study with dogs: Ho effects on behavior or
bodyweight. No neurological opthQl ologic,al, hemetologicel, nor blood
chamiatry effects. No effect on brain A E, nor on gross organ
appearance or weight. 56-week study with rate: No major effects at 10
and 30 mg/kg. EDT 180 mg/kg produced liver pericholagitis, uterine and
testicular changes with focal hamorrhage. Blood clotting parater.
were affected at lowest dose (10 mg/kg/day).
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Major Routes of Exposure: Dernal, ji K i1a io
Physiological and Ri och i cal Behavioral Characteristics:
Poltar absorption: Absorbed by leaves, but not nor.ally applied to the
foliage.
Tranaloc.at ion: Butylate is rapidly absorbed by the roots of the corn
plant and translocated throughout the ubole corn plant.
Methsni of pesticidal action: Unknown. Inhibits growth in the ri.t ic
region of the leaves of grassy weds.
Metaboli and persistence in plants and an4. ls: Metabolized rapidly
to C0 2 , diisobutylseine, fatty acids, conjugates of a nne. and fatty acids,
and certain natural plant constituants. Disappear. fr the .t s and
leaves of corn plants 7 to 14 days after trea nt.
Enviroueental Characteristics:
Adsorption and leaching in basic soil types: In sandy dry soils, butylate
leached about one—third the distance that 20 c (8 inches) of t.r ovsd.
Leaching decreased as clay and organic tter increased. In heavy clay
soils, butylate leached slightly downward 2.5 to 7.6 c (1 to 3 inches)
with 20 of water.
Microbial breakdown: Microbial breakdown play. an iaportant role in the
disappearance of butylate from soils.
Lose fro photodecosposition and/or volatilization: Butylate is lost by
vaporization when applied to the surface of wet soils without incorporation.
Very little lose occurs after application to dry soil surfaces.
Bioaccu ulation: Butylate has wderate potential for bioaccuaulation
in fish. After 28 days of exposure, bluegill simfish had bioacc*mulation
ratios of 331 aebient in edible tissues, and 119—1741 aabient in
non—edible tissues.
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lesultant average persistance: The half—life of botylate under crop
growing conditions was 1 • 5 to 3 weeks in several soils. In a loan
soil at 21 to 27 C (70 to 80 F) the half-life wee 3 weeks.
Half—life in Water: Data not yet available.
Ecological characteristics:
Hazards to Birds: Kin1 a1, owing to law toxicity and low exposure rates
Hazard. to Aquatic Invertebrate .: Min1 al, owing to aoderate toxicity
and law e osure rates
Hazards to Fish: Not fully assessed yet. Butylat. is at least derate1y
toxic to fish, bet requested data . tght show a greater toxicity. If
earlier studies prove accurate, and butylate is only aoderately toxic to
fish, the hazards to fish frc the registered use patterns are l .
Potential Proble.s with Endangered Species: None anticipated.
Tolerance Reasaea..ent:
List of crops and tolerances: Corn grain (including popcorn), fresh cori
(including sweet corn — kernels plus cob with husk roved), and corn
forage and fodder (includiug sweet corn, field corn, and popcorn) at
0.1 pp..
List of food contact uses: All corn products listed above.
Result. of tolerance .ssesswant: Aseuaing 1002 of all corn products to De
treated with butylate, the dietary burden unts to no aore than .O32
of the ADI. Reassessment has been conducted. No tolerance changes
are needed at this time.
Problems known to have occured f roe use: None
4. Sn y of Regulatory Position and Rationale :
Use Classification: General use classification.
Use, Formulation or Geographic Restrictions: Uses are l1 ited to
application to corn fields. No other restrictions.
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Unique Label warning stat ents:
Manufacturing Use Products:
Do not discharge into lakes, streams, ponds, or public
waters unless in accordance with a NPDES permit. For
guidance contact your regional office of the EPA.
End—Use Products:
Barwful if swallowed. Avoid contact with skin, eyes
and clothing. Aoid breathing spray mist. Wear goggles,
rubber gloves and protective clothing. Wash skin with
soap and water 4m ’diately after contact. Flush eyes
with water.
Do not apply directly to water or wetlands. Do not
contaminate water by cleaning of equ.ip nt or disposal
of wastes. Cover or incorporate spills.
Data gaps exist (see below), but the Agency will not cancel or withhold
registration solely because of data gaps. The available toxicity and
enviroi ental fate data indicate that butylate use is unlikely to cause
severe hazards to hunans or wildlife, and although this analysis of hazard
cannot be considered complete until the data gaps are filled, there is suf-
ficient justification for continuing the registration of butylate products.
5. Sti . ry of major data gaps
An inhalation LCyj for rats is needed, and has been required. Other
data gaps exist, but none is considered major, or as important as the
lack of an inhAlation LC 50 . The inhalation 5O iS to be supplied by
April 1985. The mutagenicity data and other data are to be supplied
by October 1987.
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Contact person at EPA : Robert Taylor, TS-767C, 401 M Street SW, Washington DC 20460
(703) 557—1800
DISQAZXEL: The inforuation presented in this Ch ical Information Fact Sheet
is for informational purposes only and may not be used to fulfill data
requir nts for pesticide registration and reregistration.
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