United State* Office of PertftidM and Toxic SutatUneci
Environmental Protection Office of Pesticide Progrtmt (TS-766C)
Agency Washington, DC 20460
v°/EPA Pesticide
Fact Sheet
Name of Chemical: DmETON
Reason for Issuance:
Date Issued: ,_ __ nnnc
_ . Febuary 27, 1985
Fact Sheet Number: 45
1. Description of chemical
Chemical Name: Mixture of 2 isomers consisting of:
0,0-diethyl 0-[2(ethylthlo) ethyl] phosphorothloate and
0,0-diethyl S-[2ethylthio)ethyl] phosphorothioate.
Common Names: Deraeton-0 + Deraeton-S, mercaptophos and
mercaptophos teolevy (USSR)
Trade Name: Systox ®
EPA Shaughnessy No: 057601
Chemical Abstracts Service (CAS) Number: 8065-H8-3
Year of Inital registration: July 15, 1955
Pesticide type: systemic acaricide/insecticide
Chemical family: organophosphate
U. S. Producer: Mobay Chemical Corporation
2. Use Patterns and formulations
Application sites: vegetable, field, orchard, and ornamental
(including greenhouse).
Types of formulations: liquid and granular
Types/methods of application: ground or air.
3. Science Findings
Chemical characteristics: light brown liquid; odor characteristic
of sulfur compounds; soluble in most organic solvents;
subject to hydrolysis under alkaline conditions; molecular
weight: 258.32.
Toxicity characteristics: Toxlclty Category I by dermal
route of exposure (lUmg/kg for male rats and 8.2 mg/kg for
female rats; Toxicity Category I by the oral route of
exposure (6.2 mg/kg for male rats and 2.5 mg/kg for female
rats); positive in mutageniclty studies in vitro in cells;
data gaps exist in the area of neurotoxlcity; chronic
toxicity, oncogenicity, teratogenlcity, and reproduction.
A gene mutation assay in mammalian cells in culture and a
chromosome aberration assay in vivo are required to be performed
to assess the mutagenic potential of deraeton.
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2
Physiological and Biochemical Behavioral Characteristics:
readily absorbed and translocated by plants; cholinesterase
inhibitor.
Environmental Characteristics: no data are available to
assess the environmental fate of demeton; no data are
available to assess demetonts potential for contaminating
groundwater.
Ecological Characteristics: highly toxic to birds (7.19
mg/kg for mallard duck and 8.21 mg/kg for pheasant); highly
toxic to fish (0.1 ppm for bluegill sunfish and 0.6 ppm
for rainbow trout); very highly toxic to freshwater
Invertebrates (0.0l’4 ppm for daphnia pulex); special tests
to monitor the residues of demeton on avian feed items
and aquatic sites are required; interim labeling to protect
endangered species to be imposed in time for the 1986
growing season if the generic (cluster) analysis has not
been completed.
Efficacy review results, where conducted: NA
Tolerance assessments: refer to the attached table for the
list of current tolerances established for demeton; available
data are not sufficient to conduct a full tolerance
assessment.
Li. Summary of Regulatory Position and Rationale
Use classification: all end—use products containing demeton
shall continue to be classified for restricted use.
Formulation or geographical restrictions: none
Unique warning statements required on labels: end-use
(EP) products require the use of protective clothing,
rubber gloves, rubber overshoes and goggles; reentry
of 48 hours, and a crop rotation restriction.
5. Summary of Major Data Gaps:
Date Due
Toxicology:
82-1 90—Day Feeding-Rodent, Non-rodent June, 1986
90—Day Feeding—Rat—Thiol Sulfoxide January, 1986
82—2 21—Day Dermal Toxicity-Rabbit August, 1985
81—7 Delayed Neurotoxicity-Hen August, 1985
83—1 Chronic Toxicity March, 1985
83—2 Oncogenicity December,1987
83—3 Teratogenicity December, 1985
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3
161—1
16 1—2
16 1—3
161—a
162—1
162—2
162—3
163—1
163—2
l6 —i
16 —3
165—1
165—2
165—a
132—1
201.1
Residue Chemistry:
September,
September,
March,
March,
March,
August,
June,
June,
June,
March,
August,
June,
March,
March,
March,
February,
March,
1985
1985
1986
1986
1986
1985
1985
1985
1985
1986
1986
1986
1985
1985
1986
1987
1987
1988
1988
1988
171— 4
171— 14
171—4
171—14
Product Chemistry:
February,
February,
February,
February,
1987
1987
1987
1987
61—2
Descripton of Beginning Materials
and Manufacturing Process
March, 1985/
August, 1985
61—3
Discussion of the Formation of
Impurities
December, 1987
August,
August,
March,
83—14 Reproduction
814-2 Gene Mutation Assay in Mammalian
Cells in Culture
Chromosome Aberration Assay in vivo
85—1 General Metabolism
Environmental Safety:
70—1 Special Test — Monitoring of residues
on avian feed items
70—1 Special Test — Monitoring of residues
In aquatic sites
70-3 Acute Toxicity to Estuarine and Marine
Organisms
Environmental Fate:
September, 1986
Hydrolysis
Photodegradatlon in Water
Photodegradation in Soil
Photodegradation in Air
Aerobic Soil Metabolism
Anaerobic Soil Metabolism
Anaerobic Aquatic Metabolism
Leaching and Adsorption
Desorption
Volatility (Lab)
Soil Dissipation
Forestry
Rotational Crops (Confined)
Rotational Crops (Field)
Accumulation in Fish
Reentry Data
Droplet Size Spectrum Testing and
Drift Field Evaluation
February, 1987
Residues in Livestock
Residues Analytical Method
Storage Stability
Residue Data on Crops
- do—
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62—1 Preliminary Analysis March, 1985/
August, 1985
62—2 Certification of Ingredient
Limits —do-
62-3 Analytical Methods to Verify
Certified Limits —do—
63—_ Physical/Chemical Properties -do-
6. Contact Person at EPA :
William H. Miller, (PM—16)
Insecticide—Rodenticide Branch (TS—767)
401 M Street, SW.
Washington, DC 2O 46O
Tel. No. (703) 557—2600
DISCLAIMER: The information presented in this Chemical
Information Fact Sheet Is for informational purposes only and
may not be used to fulfill data requirements for pesticide
registration and reregistration.
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