United State* Office of Pesticide* end Toxic Substances Environmental Protection Office of Pettlade Programs (TS-766C) Agency Washington, DC 20460 v>EPA Pesticide Fact Sheet Name of Chemical: DICAMBA. Reason for Issuance: Date Issued: Oct. 17, 1983 Fact Sheet Number: 8 1. Description of Chemical; Generic name: 3,6-dicbloro-o-anisic acid Common name: Dicamba Trade Names: Banvel, Banex, Brush Buster, Mediben, Velsicol 58-CS-ll EPA Shaugnnessy Number: 029802 Chemical Abstracts Service (CAS) Number: 1918-00-9 Year of initial registration: 1967 Pesticide type: Herbicide Chemical family: Benzoic acid U.S. and foreign producers: Velsicol Chemical Corporation 2. Use Patterns and Formulations: Application sites: corn, small grains, grain sorghum, asparagus, sugar- cane, pastures, rangeland and agricultural seed crops, noncrop sites, forest lands, lawns and ornamental turf Types of formulations: diethanolamine, monoethanolamine, dimethylamine and sodium salts as soluble concentrates or granulars. Types and methods of application: Applied by aerial or ground spray, invert system, tree injection or granular equipment. Dicamba is applied preplant, preemergence or postemergence. Application rates: 1/4 pound active per acre to grain sorgbuc 1/8-1/2 pound active per acre to small grains, asparagus 1/4-3 pounds active per acre to sugarcane 1/2-8 pounds active per acre to pasture, range and noncropland 1/4-1 pound active per acre to turf and grass seed crops Usual carriers: water, fluid and dry fertilizer, oil in water emulsions, clay or vermiculite 3. Science Findings; Summary Science Statement: Dicamba appears to pose little acute toxicity or environmental hazard. The major problem appears to be the potential for a dimethylnitrosamine (DNNA) contaminant in the dimethylamine formulations. The level of DMNA is expected to be beicw 1 PP* and the risk level for dicamba with DNNA is 10~7 to 10~8 range. ------- —2— Chema.ca.l Characteristics: It is a light tan slightly phenolic crystalline solid. It is stable to oxidatior and hydrolysis and melts at temperatures between 90- 100•C. Dieamba is nortflkm, ble and does not present any unusual handling hazards. Toxicology Characteristics: Acute Toxicology Results: Oral LD 50 in rats: 2.74 mg/kg body weight, Toxicity Category III Dermal LD 50 in rats >2,000 mg/kg, Toxicity Category IV Inhalation LC 50 in rats: >200 mg/i, Toxicity Category IV Eye irritation in rabbits: Induced corrosiveness of con— unctival tissues and corneal injury i .cn was reversible in 72 hours. In a recent study eye ti t ge was irreversible and pannus was observed. Toxicity Category I. Dermal Irritation: slight dermal irritation. Chronic Toxicology Results: Teratology in rabbits: NOEL of 3.0 mg/kg/day for maternal toxicity; not teratogeru.c. Teratology in rats: Teratology NOEL — 400 mg/kg; maternal toxicity NOEL — 160 mg/kg Three—generation reproduction study in rats: No evidence of toxicity among the rats from any of the generations in the study. No test article related effects were eviden: for any reproductive indices examined. NOEL of 25 mg/kg/day. 90-day subchronic feeding study with rats: Tne NOEL is 250 mg/kg/day. LEL was 500 mg/kg/day (slight de- crease in comparative body weight gains and food con- sumption and evidence of reduced glycogeri storage). Major Routes of Exposure: Dermal and inhalation exposure to hum&nB may occur during application, particularly via splashing during .lu- tion, izing and loading. Application by aircraft increases the potential for exposure of huiw s, livestock, and wild- life due to spray drift and ventilation. ------- —3— Risk Assessment and Cont* ‘santa: The manufacturing process for dicamba has potential of resulting in traces of 2, 7 —dichlorodbenzOPdiOz1.fl as a contaminant. It is present at level. up to 50 ppb (parts per billion). The more toxic dioxir’ isomer, 2,3,7 ,8—tetra- chlorod.thenzo—p-diOXifl , has not been found at the limit of detectiam (2 ppb) of the method and is not expected as an impurity in dicamba. Dicamba products formulated with the dimethylamine salt have the potential of adding a dimethylnitrosamine (D10U 1 ) conta - nant. Nitros 4 v’e levels in the dimethylamine for ’ etions are expected to be less h* t 1 ppm. The risk lave].s for the dicamba products with the attrosamins contaminant are in the 1 x i0 to 1 x range. The benefits outweigh the risks associated with the nitro- s ’ es. The performance of th. dice a cont iT ing herbicides is such that they are viable alternatives to the suspended uses (home lawns, pa. tures, ditchbanks and forests) of silvex and 2,4,5—T. Physiological and Biochemical Behavioral Characteristics: Foliar absorption: Readily absorbed by leaves. Translocatiorl: Dicamba is absorbed by leaves and is readily moved to other plant parts. Mechan.tem of pesticidal actions: chibits properties of an auxi ’-like plant growth regulator. Plant metabolism: Rapidly absorbed and metabolized almost entirely into soluble metabolites and insoluble plant products (celluloses). nim&l metabolism: Some dicamba is demethylated to the mete- bolite, 3,6 —dichlorO-2hydroXybeELZOiC acId. Most dicumba 1.8 excreted rapidly in urine as the free and/or con)ugated form. Environmental Characteristics: AdsorptIon and leaching in basic soil types: Dicamba (free acid and dimethylamine salt) i adsorbed to peat, but not appreciably adsorbed to soils ranging tram heavy clay to loamy sand. ------- —4- Dicamba is readily mobile .ri soils anca .ng from clay to loamy sand. Microbial breakdown: Under aerobic conditions in soil dicamba degrades with half-lives ranging from I to 6 weeks depending on soil texture. Degradation rates are slowed by decreasing teaperatures (<20C) and decreasing soil moisture below field capacity. Loss from Photodecc.position and/or volatilization: Phytotoxic dicamba (free acid) residues are photodegraded in water to nonphytotoxic levels. Dieamba is volatile with losses of 60% in glass flow tubes and 49% from thin films. Data from sterile and nonaterile soil samples indicate that larger losses of dicamba are due to metabolism rather than to volatilization. Resu.ltant average soil persistence: Dic-amba nas a half—life of I to 6 weeks. It may be leached out of the zone of activity in h .id regions in 3 to 12 weeks. Dicamba may persist Longer under conditions of low soil iature and rainfall. Ecoloaical aracteristics: Avian oral LD 50 >2,510 mg/kg (practically non—toxic Avian dietary LC 50 > 10,000 p (practically non—toxic) Aquatic invetebrates LC 50 100 mg/l (practically non-toxic) Cold water fish W 50 — 135.3 mg/i (slightly toxicity) Warm water fish “ so >1,000 mg/i (practically non—toxic) Avaiiable data indicate that dicamba is practically non-toxic to fish and wildiife and unlikely to directly affect these organisms. Use patterns of the chemical do not present any prok lea to endangered species. Tolerance Assessments: Crops and tolerances: 0 • 1 ppm on sugarcane, sugarcane fodder and sugarcane forage. 0.2 ppm on meat, fat and meat byproducta (except liver and kidney) of cattle, goats, hogs, horses and sheep 0.3 ppm on milk ------- —5— 0.5 p a on barley grain and barley straw; corn fodder, forage, and grain; oat grain and oat straw, and wheat grain and wheat straw. 1.5 on kidney and liver of cattle, goats, hogs, horses and sheep. 2.0 pps on sugarcane molasses (food/feed additive tolerance) 3.0 pp. on asparagus, aorght fodder, forage and grain 40.0 pp. on grasses, bay; grasses, pasture; grasses, rangeland. Results of tolerance assessment: The available residue data support the existing tolerances. Tolerances on aorghta milling fractions, poultry and eggs may be required once requested residue data and poultry feeding are submitted. Based on a NOEL of 600 pp. (rat subchronic study) and a 2,000—fold safety factor, the existing tolerance utilizes 37.58% of the PADI. Problems which are kn n to have occurred with the use of the chemical: Based on the pesticide Incident )bnitoriflg System (Pill’s) report, most reported incidents with dicamba involve phytotoxicity to adjoining crops because of drift. 4. Si ary of Regulatory Position and Ratioss!! ’ Use Classification: Gen•ral Use s ary of risk/benefit review: The risk level for dicamba products containing DIQIA is in the to 10-8 range. The Agency considers that the benefits outweigh the risk associated with the nitrosamines. The product performance of djcamba-COfltaifliflg herbicides is such that they are viable alternatives of several of the suspended uses of silvex and 2,4,5— T, such as for home lawns, pastures. along ditcbbanks and brush control in pastures. Use Restrictions: Dicambe ay not be used in any way which contaminates irrigation ditches or vatsr for domestic purposes. Unique label warning statement: Crops for which dicamba is not registered may not be planted in dicaaba-treat.d fields. ------- —6— 5. Su ary of Data Gaps and Dates When These Gaps Are tobe Filled : Residue data on poultry, eggs, and sorghi October 1987 Milling fractions October 1987 Poultry feeding study October 1987 Hydrolysis October 1987 Photodegradation October 1987 Laboratory etaboliaa studies October 1987 Pbbi lity October 1987 Field dissipation studies October 1987 Accumulation studies October 1987 90—day feeding (Nonrodent) October 1987 Chronic feeding/oncogenicity (2 species) October 1987 Mutagenicity test October 1987 6. Contact person at EPA : Robert J. Taylor Environmental Protection Agency (TS—767C) 401 N St. S W. Washington, DC 20460 (703) 557—1SOC ------- |