(Ailttd Stttm wig, of PwiddM ind ToKie SubMitos Envlronnrniul Protection Offiet of P««Wd» ProBram (T8-766C) Washington, DC 20460 xe/EPA Pesticide Fact Sheet Name of Chemical: DISUlrara Reason for Issuance: Date Issued: Fact Sheet Numb*?' DESCRIPTION OF CHEMICAL Generic Name: 0,0-diethyl S-[2-(ethylthio)ethyl] phospho- rodithioate Common Name: Disulfoton Trade Name: Di-Syston EPA Shaughnessy Code: 032501 Chemical Abstracts Service (CAS) Number: 298-04-4 Year of Initial Registration: 1958 Pesticide Type: Insecticide/Acaricide Chemical Family: Organophosphate U.S. and Foreign Producers: Mobay Chemical Corp. USE PATTERNS AND FORMULATIONS Application Sites: Grain crops, nut crops, cole crops, root crops, pome, strawberry and pineapple fruits, forage, field and vegetable crops, sugarcane, seed crops, forest plantings, ornamentals, and potted plants (including houseplants) Types of Formulations: Emulsifiable Concentrates, granulars, pelleted/tableted, and ready to use liquids Types of Methods of Application: Soil incorporation of granulars, ground and aerial spray and granular broadcast applications ------- Disulfoton 2 fact sheet Application Rates: Range fran 0.25 lbs. a.i./A to 8 lbs. a.i./A for bro ast applications and .25 oz ai.i./1000 ft. r to 10 oz. a.i./1000 foot row for band trea rent; also individual potted plant soil treatment uses at various rates depending on plant and pot size. Usual Carriers: Synthetic clays, various solvents, fertilizers 3. SCI 4cE FIN I S Summary Scienoe Statement Disulfoton is very highly toxic to all ma!Inalian systems by all routes of exposure and is assigned to xicity Category t, on the basis of ecute toxicity requiring the most stringent labeling precautions and use restrictions. It is not considered to be orcogenic, mutagenic, or teratogenic based upon existing data. B ver, additional studies in a second species are being requested to fully assess orcogenic and teratogenic potential. ditional iaitagenicity studies are also being required. Raprod tion data is lecking and is required. tX e to the high ecute toxicity and cbolinesterase inhibition of disulfoton the Pgercy is imposing a 24- ur reentry restriction for crop uses until appropriate reentry studies and dennal absorption data are subnitted and evaluated and a decision is reeched whether a different time interval is more appropriate. Data are insufficient to assess the environn ntal fate of disulfoton. The Agercy is requesting necessary data to make this asses nt and also to specifically assess whether or not disulfoton will leech into ground ter. Considering the high ecute toxicity of disulfotcn spray drift data are being required to measure human and non-target organi n exposure resulting fran spray applications and dennal and thhalation exposure data are being required to measure rker exposure in outdoor applications. Disulfoton is very highly toxic to fish, maT als, highly toxic to birds, and moderately toxic to boney bees. Full field monitoring studies are required for the terrestrial uses to assess the exposure potential. Based on these results and on the results of the outstanding enviroui ntai. fate data, chronic studies for both aquatic and terrestrial species may ------- Disulfoto 3 fact sheet be required as .wall as full field mc*iitoring studies for the aquatic uses. Use precautions and restriction are being licpoeed in the interim to red ce potential hazards. A nunber of terrestrial and aquatic endangered species have been identified as at risk fran the use of a minber of ch nicals, including disulfoton on certain crops. This issue is currently being idressed as part of a cluster approech. Interim labeling to protect these species may be necessary if the cluster analysis is not ca çleted by 1986. A full tolerance reassessriertt cannot be canpieted. The previous ADI was established using a rat chronic feeding study which was found to be un ceptable. The present Prov .sional ADI was based on a dog chroni c feeding study. The percent of the PADI utilized is 169%. A second rat chronic feeding study is required, as ll as an ina.1 mataboli n data to quantify and qualify disulfoton oxidation metabolites in meat, milk, poultry and eggs and residue data on nu rous cicpv yjitjeg . The Agency is requiring that when the tolerance reasses ient is m ji , after receipt of the requested data, all tolerances are to be calculated and expressed in te of disultoton sulforte, the major metabolite, rather than as ton (which is F w the Agency previously expressed tolerances for disulfoton). Ch nical Char teristics Physical State: Liquid Color: Pale yell Odor: Unkr n Boiling Point: 62° C at 0.01 niw’Hg vapor Pressure: 1.8 X millibars at 20° C Flash Point: >180° F(IOC) Toxicoloqy Charecteristics Pcute Oral: 1.9 — 6.2 mg/kg, Toxicity Category I ------- Disulfo ton 4 fact sheet ute Dar’n 1: 3.6 — 15.9 mg/kg. TOxicity Category I Primary Daz7naJ. Irritation: NA since chemicals toxicity uld preclude testing for this requir nt Pcute Inhalation: One study, which did not meet Agency standards, indicated toxicity at 0.2 mg/i, which uld place it in TOxicity Category t. - Neurotoxicity: One study was subnitted which did not meet Agency standards. The study did not indicate delayed neurotoxic effects. Orrogenicity: T studies have been evaluated; one was acceptable and did not suggest oncogenic potential. Teratogenicity: T studies re evaluated; one was acceptable and the other did not fully meet the Agency standards. The ch nical is not teratogenic at 0.3 mg/kg/ day. prodtet.ion — 2 generation: Data gap Metaboliem: The available studies suggest that disu.1foton is rapidly absorbed and may undergo sequential oxidation steps that enhance anti-cholinesterase properties. retion 4.5 canpiete and rapid via urine. Major metabolites include the 0—analog of disulfoton, and the sulfoxide and sulfone derivatives of both disulfoton and its 0-analog. Data to further deecribe the nature and dynanics of this process are necessary. Mutagenicity: Contradictory reports are available on the niitagenic potential of disulfoton. ? gerry has concluded that the imatagenic potential is not adequately defined and further testing is necessary. Physiological and Biochemical Behavioral Characteristics Mechanian of Pesticidal Aticn: A plant systemic insecticide which is active by contact, ingestion, and vapor action. Disulfoton and its major metabolites are potent cholinesterase inhibitors primarily attacking acetyicholinesterase. Poisoning and death results fran e cessive stiimilation of both the parasympathetic and central nervous syst , and the consequent myoneural junction effect as a result of acetyicholinesterase acc unulat ion. ------- Disulfoton fact sheet 5 S ’inptans of Poisoning: headahe, dizziness, extreme weakness, ataxja, tiny pupils, twitching, tr r, nausea, slow heartbeat, pulnxxiary edema, and e essive sweating. Continual daily absorption at inte diate doses may cause influenza—like illness char terized by weakness, anorexia, and malaise. Metaboli n and Persisterce in Plants and Animals : The metaboli n of disulfoton in plants is adequately understood. The major plant metabolite appears to be disui.foton sulfone. Consequently the Agercy believes that the tolerarces for disulfoton residues should be expressed as disulfoton sulfone. The metaboli n in animals is not well understood. More data are required to quantify and qualify animal metar olites, and to quantify plant inetabolites. Erivirorunenta.l Char teristics Available data are insufficient to assess the envirorunental tate of disulfoton. ta gaps exist for virtually all required studies. In order to charsoterize the potential of the c ical to contaninate groundwater adsorption and le hing stt ies are being requested by the Agercy. Droplet Size Spectr testing and Drift Field Evaluation studies are being requested in order to dete nine the m nitude of exposure to non—target organians. Ecological Char teristics Avian Oral: Mallard d ck — 6.54 uq/kg Bobwhite iail — 12—31 n Jkg Avian dietary: Mallard dtck — 510—692 ppn Bobwhite quail — 541—715 ppn ring—necked easant — 634 ppn Freshwater fish: coidwater fish (rain ” trout) — 3.0 ppn wauT ater fish (bluegill sunfish) — 0.039 p Pcute Freshwater Invertebrates: (All studies listed were not cord cted cording to Agency standards) ------- Disulfoton fact sheet 6 Acute Estuarjne and Marine Organisms: Data gaps Precautionary language is being required to mitigate hazards to birds, fish, and aquatic organisms. Additional labeling to protect identified endangered species may be required at a later date. Because of the lack of environ- mental fate and field monitoring data to quantify exposure of disulfoton to these organisms, the Agency can not quantify the hazard potential. Additional chronic toxicity studies may be required depending on the results of the environmental, fate and field monitoring data. Tolerance Assessment The Agency is unable to complete a tolerance reassessment because of certain residue chemistry and toxicology data gaps. Tolerances: Con odity Parts Per Million alfalfa (fresh) 5.0 alfalfa (hay) 12.0 asparagus 0.1 barley (fodder, green) 5.0 barley (grain) 0.75 barley (straw) 5.0 beans (dry) 0.75 beans (lima) 0.75 beans (snap) 0.75 beans (vines) 5.0 beets, sugar (roots) 0.5 beets, sugar (tops) 2.0 broccoli 0.75 brussels sprouts 0.75 cabbage 0.75 caulifower 0.75 clover (fresh) 5.0 clover (hay) 12.0 coffee beans 0.3 corn, field (fodder) 5.0 corn, field (forage) 5.0 corn, grain 0.3 corn, pop 0.3 corn, pop (fodder) 5.0 corn, pop (forage) 5.0 ------- • Disulfo ton fact sheet 7 Tolerances (COn’t): Cou!nodity Parts Per Million corn, sweet (fodder) 5.0 corn, sweet (forage) 5.0 corn, sweet, grain (kernels plus cob with husks removed) 0.3 cottonseed 0.75 hops 0.5 lettuce 0.75 oats (fodder, green) 5.0 oats (grain) 0.75 oats (straw) 5.0 peanuts 0.75 peanuts (hay) 5.0 peanuts (hull) 0.3 peas 0.75 peas (vines) 5.0 pecans 0.75 peppers 0.1 pineapples (forage) 5.0 potatoes 0.75 rice 0.75 rice (straw) 5.0 sorghum (fodder) 5.0 sorghum (forage) 5.0 sorghum (grain) 0.75 soybeans 0.]. soybeans (forage) 0.25 soybeans (hay) 0.25 spinach 0.75 sugarcane 0.3 tomatoes 0.75 wheat (fodder, green) 5.0 wheat (grain) 0.3 wheat (straw) 5.0 Based on established tolerances the theoretical maximum residue contribution (TRMC) for disulfoton residue in the human diet is calculated to be 0.2544 mg/day. The provisional acceptable daily intake (PADI) of disulfotort is 0.0025 mg/kg/day. The maximum perinissable intake (MPI) for a 60 kg person is 0.15 mg/day. The percent of the ADI utilized is 169%. However a reassessment of the current tolerances based on actual constituents of the plant residues (xnetabolites) is necessary as well as toxicity ------- Disulfoton fact sheet 8 data on the most toxic metabolite. Conformity of U.S. tolerances with Canada and Codex Alimentaruis tolerances is withheld pending receipt arta- evaluation ot appropriate data referred to above. U.S. tolerances for most raw agricultural commodities are not supported by current residue data. More data are required. 4. SUMMARY OF REGULATORY POSITION AND RATIONALE The Agency has determined that it should continue to allow the registration of disulfoton. Adequate studies are available to assess the acute toxicological effects of di— sulfoton to humans. one of the criteria for unreasonable adverse effects listed in section 162.11(a) of Title 40 of the U.S. Code of Federal Regulations have been met or exceeded. However, because of certain gaps in the data base a full risk assessment of disulfoton cannot be completed. Also, a full tolerance reassessment cannot be completed because of certain residue chemistry and toxicology data gaps. The Agency is concerned about whether or not the potential total human exposure to disulfoton and its metabolites, both from direct and indirect human contact and the ex- ceeded ADI, poses any unacceptable hazards. To resolve this concern, additional residue, metabolism and exposure data are required, and until it is resolved no new uses will be granted. All end—use products formulated at greater than 2% are classified for Restricted Use, pending receipt and evaluation of appropriate acute toxicity data. Acute toxicity data on products 2% and less are being required in order to determine the appropriateness of a Restricted Use classification. These steps are being taken due to the extreme toxicity of disulfoton and the lack of product specific acute toxicity data. A federal 24—hour reentry interval is established for treated crop areas until reentry and dermal absorption data are sub- mitted, as required, and the Agency decides on the most appropriate time interval. ------- Disulfo ton fact sheet 9 Available data are insufficient to fully assess the env iron— mental fate of disulfoton. The Agency is requesting data to determine if disulfoton will contaminate groundwater. Toxicity data available for disu].foton indicates that it is highly toxic to aquatic, terrestrial and avian species. Data to assess the extent of the potential exposure is currently lacking and is required to complete the hazard assessment. 5 • SUMMARY OF MAJOR DATA GAPS Additional residue data on various raw agricultural and processed commodities are being required. Also additional chronic toxicity, oncogenicity, and rnutagenicity data are needed to better define the long term effects of this chemical. Plant and animal metabolism, exposure, spray drift, reentry and subchronic toxicity data are required to better qualify and quantify human exposure to residues of disulfoton and its metabolites, both from dietary and non—dietary sources. Other requirements Acute Inhalation Acute oral, dermal and inhalation studies on formulating intermediates and end—use products Acute delayed neurotoxicity Dermal absorption study Product Integrity study Hydrolysis study Photodegradation studies Soil and Water Metabolism studies Mobility studies Volatility studies Dissipation studies Accumulation studies Large Scale Field Monitoring studies Acute freshwater invertebrates testing Acute estuaring and marine organisms testing Honey bee toxicity of residues on foliage study ------- 4)i sUlfoton 10 fact sheet 6. COMPLIANCE DATES FOR REVISED LABELING —For addition of RESTRICTED USE classification to product formulations containing greater than 2% dlsulfoton. All such products released for shipment after September 1, 1985 must bear RESTRICTED USE labeling. All such products in the channels of trade after September 1, 1986 must be labeled for RESTRICTED USE. —For intrastate products the Agency Is requiring submission of applications for full registration of all intrastate products containing disulfoton by December 31, 1985 . Holders of such intrastate products who request withdrawal or who fail to respond to the notification, may not distri- bute or sell the intrastate product after December 31, 1985 . Products already in the channels of trade as ot that date may continue to be distributed and sold by dealers and retailers until June 30, 1986 . Any product found in the channels of trade after June 30, 1986 will be considered to be in violation of FIFP.A sec. 12(a)(1)(A). CONTACT PERSON AT EPA George T. LaRocca Product Manager (15) Insecticide—Rodenticide Branch Registration Division (TS—767C) Office of Pesticide Programs Environmental Protection Agency 401 M Street, S.W. Washington, D.C. 20460 Office location and telephone number: Room 204, Crystal Mall *2 1921 Jefferson Davis Highway Arlington, VA 22202 (703) 557—2400 DISCLAIMER: The information presented in this Chemical Information Fact Sheet is for informational purposes only and may not be used to fulfill data requirements for pesticide registration and reregistration. ------- |