UnftKi Sttt« Offloi of PMtefctai and Toxfe SufacuncM Environmental Protection Offie* of PMiddt Program (TS-766C) Agmcy Wwhington, DC 20460 x°xEPA Pesticide Fact Sheet Name of Chemical: Reason for Issuance: Date Issued: <**• 3' 1983 Fact Sheet Number: e 1. Description of the chemical: Generic name: S-ethyl dipropylthiocarbamate Trade name: ChemollmpeiDw, Eptam*, and Bradi'cane* EPA Shanghnaaay Coda: 041401 Chmlcal Atecracea Sarriea (CAS) Eeglatry noabar: 759-94-4 Taar of initial ragiatration: 1969 Paacieida Typa: Harbicida Chamical faaily: Thlocarbaaata U.S. and Foreign Producer: Stauffer Chemical Company 2. Dae patterns and formula tiona: Application aitaa: EPTC ia a aelectlve "tbiocarbamate" herbicide wblcb ia regiatered for oae in preemergent control of certain annual graaaea, broadleaf veeda and perennial weeda, avcb aa quackgraaa, bermndagraaa» and nutaedge on field , vegetable* orchard, ornamental and nonerop aites. Types of f ormnlationa : EPTC ia available in granular and emolaifiable liquid concentrate formolationa. Type* and methoda of application: EPTC must be incorporated in the aoil by diacing, applied with aubanrface injection equipment, or metered into irrigation mater to obtain proper weed control. The apecific method of application and type of equipment are determined by aite, formulation, and availability of equipment. Application ratea: 2.0* Iba. a.i./A to 7.0 Iba. a.l./A. Daual carriers: Water and clay. 3. Science Findings; try science statement: EPTC la potentially a strong eye irritant bat it has low acute tori- cities. Since EPTC is incorporated into the aoil immediately or just after planting, it will not preaent a hazard to birda and aquatic organisms. At least two chronic toxicology studies are required to complete the data base. Chemical characteristics: Technical EPTC ia a light yellow liquid. At room temperature, EPTC la a liquid and it baa an amine odor. EPTC boila at ca 235* C. The eta leal does not preaent any unusual handling haaarda. ------- —2— Toxicological characteristics Technical EPTC is potentia 1 ly a strong .ye irritant (Toxicity Cate- gory II). The available data also indicate that technical EPTC has relatively low acute oral, dernal, and inhalation toxicities, and low potential for priry derwal irritation. Studies on buty]ate (a close structural relative of EPTC), as waU as studies on £PTC itself, have indicated effects of ixpaired clotting function in test aI ls. Therefore, any additional studies on EPTC auat include a test for clotting function and h. tology in the protocol design to better define the effects on clotting and clearly establish a no obser ed—effectlevel (NOEL). Acute toxicology studies on TC are as follow,: Oral LD 50 in rats: 1,632 aaJkg body weight, Toxicity Cat.gory III Oral LD 50 in nice: 3,160 ag/kg body weight, Toxicity Category I II I,ik*1 tion LC 50 in rats: 4.3 ag/l, Toxicity Category III Deral LD 50 in rabbits: 2,750 ag/kg bodywsight, Toxicity Category III Prisary Eye Irritation in rabbits: severe eye irritant, Toxicity Category II Priaary Dereal Irritation in rabbits: aild skin irritant, Toxicity Category IV. Chronic toxicology studies on TC are as foLlows: In a 54-week feeding study of TC in rats: the sOIL was 20 ag/kg/day; the IlL was 80 ag/kg/day. In a twa year chronic feeding and oncogenicity study of TC in nice: the IL was 20 ag/kg/day; the IlL was 80 ag/kg/day and no evidence of t rig.nicity was found. General taboliwa: !C studies in nel. and f l. rats wars reviewed and satisfied the current data requir t 5 for aninel tabol- Major routes of bian sxpos .: Current data does not 1nMcate that the U.S. population is exposed to EPTC through the dietary or non-dietary routes. by a iologica.l and Biochenical Behavioral Characteristics: Poliar absorption: EPTC is absorbed stly through the plant roots nith littl. or no foliar penetration. Tracalocatiofl: EPTC is readily absorbed by roots and translocated upward to th. leaves and st . i h* (s* of pesticide 1 action: rC disrupts the growth of asrist tic regions of th. leaves and protein synthesis. Mataboli and Persistence in Plants: EPTC is rapidly .stabolized by plants to and c ”n plant constituents ( sai’io acids and trncto.e). ------- —3— E i O Ut&1 characteristics: Adsorption and leaching characteristics in basic soil types: EPIC is adsorbed onto dry soil • The of leaching decreases as clay and organic eettar increases. Nicrebikt brsskd : Microbes are the prlaarY factor in the breakdown of EPTC Lu soils. Loss f row photod.eoPOsitiOn and/or volatilization: EPIC is readily lost f row volatilization miess it is iediately incorporated in the soil at t1 of application. Awsrage persistence at r.c nded rates: The half hf. of EPIC in soist lo soil at 21 to 27C is approx1i’ telY one week. Ecologic*l cbaractarist ice Avian oral I D 50 : > 26,000ppe, Avian dietary LC 50 : > 20,000 ppe, Fish LC 50 : 17.0 ppe to 27.0 ppe, Probleea with aquatic organisas are not anticipated because an estiwated .uviro ntal concentration of 0.141 pps in EPIC runoff is well below the for aquatic organia. Ths low to city and plae nt of EPIC into the soil i—.diats.ty prior to or 3ust after planting should reduce exposure and provide an adequate safety rgin. Tolerance asses .1nt: Tolerances are e.tabl.ishad for n.ghigible r.siduss (N) of th. herbicide S-ethyl dipropyitbioc&rbte Lu or on the following raw agricultural c. —-ditie.: Parts p .r 411i Al.soada, b” 0.1(1) Mpsragus 0.1(N) Mans, castor 0.1(N) Cotton, forags 0.1(N) Cottonseed 0.1( 1) P1 seed 0.1(N) Fruits, citrus 0.1(N) Fruits, s.aLl 0.1( 1) Grain crops 0.1(1) Grasses, forage 0.1( 1) L.g a. forage 0.1(1) ts 0.1( 1) Pineapples 0.1( 1) Safflower, s 0.1( 1) Strawberries 0.1( 1) Sonfl r, seed 0.1(5) V.getablsa fruiting 0.1(5) Vegetables, leafy 0.1(N) Vegetables, root crop 0.1(5) Vegetables, seed and pod 0.1(N) ------- -4- Problene known to hs,e occurred with use: The Pesticide Incident Monitoring Systee (PDIS) indicated at least four cases involving EPTC alone f ron 1966 to 1979. In these reports, agricultural workers such as aixers, loaders and applicators received dical treatwent after the pesticide contacted their eyes. The exposures ware caused by equipasut failure, or splashing and resulted in irritation, swailing, redness, and infltion of the eyes. No fatalities ware reported. PDIS is a voluntary reporting sy.t and do... not include detailed follavup or validation of reported incidents. 4. S —ry of regulatory position and rationale : U.. classification: General use classification. Use, forwulation or geographical restrictions: No use, forvulation, or geographical restrictions are required. Uniqun label warning stat nt: None Su ry of risk/benefit review: No risk asses nts ware condiw ted. 5. S& ry of jor data gaps : The following to cological studies are required within four years after the receipt of the guidancs package. A 1—year or longer dog feeding study, A rat onc g.nicity study, A teratology study in two specie . , A 2—generation reproduction study . * A teratology study (CDL:247780) aubaitted by Stau.ffer Ch ical Coupany is pending review by the Agency. * A reproduction study ( L:249O77) anbaitted by Stau.ffer Ch ica1 Conpany is pending review by the Agency. Th. requir nt for a subchrontc uaurotoxicity study is being deferred until an &cut n.urotoxicity study has been cospleted in order to deterain. wbether the .ubchronic study is necessary. This study at be suheitted wiPh1vt six south. after receipt of the guidance package. ------- —5— The following .nviro nta.l fat, data are r.quirsd within four y.are .1 tsr the receipt of the guidance package. Rydrolysis test, Pbotod.gradation ts.t in tsr, Mstabolius teat in anaerobic soil, Mobility (volatility) teat in the lab, Dissipation stedy in soil, Mciulation study in c binod rotational crop.. 6. Contact Person at KP* : Robert J. Taylor Product Manager (25) Registration Division (TS-767C) Pungicidr erbicids Iranch 401 M Str.st, S.W. Washington, D.C. 20460 (703) 557—1800 DIS Afl 3: The infornatian presented in this Cbical Infornation Pact Sheet is for inforeatiollal p pos.s only and nay not be used to fulfill data requirnasuts for pesticide registration and reregistration. ------- |