United Statv             OHiot of Parttcfcta and Toxic SutaancK
                 EnvironnMntal Protection      OHiof of Pttldd* Program (TS-766C)
                 Agmcy                 Wwhlngton. DC 20460

                 Fact  Sheet
                 Name of Chemical:    FEN&GNOSULF
                 Reason for Issuance:
                 Date Issued:     Oct. 14, 1983
                 Fact Sheet Number: 10
    Description of the Chemical;
    Generic one:  p-(dlmethylamino)benzenediaro  sodium sulfonate
    Coanon name:  Fenamlnosulf
    Trade name:  Lesan.  Dexon, Bayer 22555, Bayer 5072, dlatoben
    EPA Shaughneaay Code: 034201
    Chemical abstracts aervlce (CAS) number:  140-56-7
    Tear of Initial registration:  1959
    Peatlcide type:  Fungicide
    Chemical Family:  sulfonated phenyl dlazo
    U.S. and foreign producer:  Mobay Chemical Corporation

2.  Uae Patterns and Formulatlona;

    Application sites:  vegetables, ornamentals,  lawns, and turf
    Types and methods of application:  dry or as  a slurry, soil drench,
    foliar spray or protectant seed treatment
    Application rates:  0.005 to 17 Ib al/A on crop sites
    Types of formulations:  Available as a wettable powder, dust and
    granular formulations  (801 technical product; 70,35,32, and 51 HP;
    2,51 D; 5 and 0.4Z C)
    Usual carrier:  water

3.  Science Findings:
    Summary science statement:
    There are extensive data gaps for Fenamlnosulf.  No human toxlcological
    hazarda of concern, other than mutagenlcity,  have been identified in
    studies reviewed by the Agency for the standard.  The Agency has no
    Information that indicates  continued use will result in any unreasonable
    adverse effects to man or his environment during the time required
    to develop the data.

    Chemical characteristics:
    Fenamlnosulf Is a yellowish-brown, odorless powder.  It is soluble
    in water (2-3Z at 25"C). The chemical does not present any unusual
    handling hazards.

    Toxlcologlc characteristics:
    Chronic toxicology studies:
      Mutagenlcity:  positive results
      Fenamlnosulf Is structurally related to the ato dyes that are
      known carcinogens

    Major routes of exposure:  dermal and inhalation from field uses

Physiological and biocb ica1 behavioral characteristics:
Mechaniu of pesticidal action: appears to inhibit itochondrjal
Metaboli and persistence in plants and aniaals: There is no data
on plant and aniaal tabolin or bioaccu.ulation potential.
Envi roiental characteristic.:
Absorption and leaching in basic soil types: appears to degrade
with a half—life of 2 days in soil
Studies are inadequate to reach a final conclusion about the fate
of Penaainosulf in the environnt or the exposure potential of
the ch ical to htans and wildlife
Ecological characteristics:
Hazards to fish and wildlife:
Avian acute oral LD 50 : 13 .g/kg
Avian subacute dietary LC 50 : 250 pps
Fish IC 50 : >60 pp
Aquatic invertebrates LC5C): Scuds 3.7 p ; Stoneflies 24 p
Potential probleas for endangered species: The use patterns do not
present any prob]ea to endangered species.
Tolerance Assess nts:
There are no tolerance, established for Fenaainosulf rssidues in
or on any crop, or aniaal product. When the cbeaical wns first
registered, seed treataents i re considered non—food uses. The
Agency’s current position is that seed treat nts are considered
food uses until data is subaitted shoving no uptake of the
chealcal or its’ degradat... Therefore etabolic studies are
needed to deteraine the residues of concern and if tolerances
be established. If tolerances need to be established
additional data requireaents aay have to be t.
Probleas known to have accurred froa use: (PINS) There have been
21 cases of exposure reported fros aixing, loading, or field
reentry. No exposures have resulted in fatality.
4. S” ry of Regulatory Position and Rationale :
Use classification: general
5. Stt nry of Major Data Gaps :
Product Che.istry: studies due 5/84
Discussion of foraation of ingredients
Preli.inary analysis
Analytical thods
Certification of halts
Physical and chealcal characteristics
Reaidue Cb istry: studies due 11/87
Plant residue
Aniasi residue
Meat/.ilk/poultry/eggs residue

Enviroi ental Fate: studies due 11/87
Bydro lys is
Photodegradat ion
Aerobic metabolism
Leaching and abeorptiOfl/deeorPtiOD
Fish accumulation
Toxicology: atudies due 11/87
Primary eye irritation — rabbit
Primary dermal irritation
Dermal sensitization
Acute Oral 50 — rat
Acute Dermal LD 50 — rat
Acute Inhalation LC 50
21 day dermal
Chronic toxicity — 2 species
OncogenicitY — 2 species
TeratogenicitY — 2 species
ReproductIon, 2 generation
Gene mutation
Chromosomal aberration
General metabolism
Wildlife and Aquatics: studies due 11/87
Avian dietary — upland game
Acute LC 5 j — invertebrates
6. Contact person at EPA :
Mr. Henry H. Jacoby (PM—21)
Environmental Protection Agency
FungicideHerbicide Branch (TS 767—C)
401 H St., S.W.
Washington, D.C. 20460
(703) 557—1900
DISCLAIMER: The information presented in this Chemical Information
Fact Sheet is for informational purposes only and may not be used to
fulfill data requirements for pesticide registration and reregistration.