United States Offios of Pertteidei end Toxic Sub«tane« Environmental Protection Office of Pettied* Program (TS-766C) Agency Wellington, DC 20460 v°/EPA Pesticide Fact Sheet Name of Chemical: Reason for Issuance: Date Issued: ***<* 31' 1985 Fact Sheet Number: 49 1. Description of chemical; Generic Name: naptalam, naotalam sodium Conmon name; naptalam (WSSA, BSI, ISO) Trade name: Alanap-L • EPA Shauqhnessy Code: 030702 Chemical Abstracts Service (CAS) Number: 132-66-1 Year of Initial Registration: 1949 Pesticide Type: Herbicide Chemical family: Phthalic acid U.S. and Foreign Producers: Uniroyal 2. Use patterns and formulations; Application sites: Liquid and granular naptalam are used as selective preemerqence herbicides for the control of a wide range of annual broadleaf weeds and grasses in soybeans, peanuts, cucumbers, melons, and established woody ornamental stock. Naptalam mav also be applied after emergence on soybeans. Types of formulations: Liquid and granular forms. Types and Methods of Application: Planter-mounted preemerqence herbicide spraver, aerial spravinq, or qranular applicator. Applications may be preemerqence, or oostemerqence in soybeans and cucurbits. One application per year, except on cucurbits, where there may be two. Application Rates: Por the liouid formulations, rates ranqe from 2.0-6.0 Ibs ai/A, except on ornamental nursery stock, where 8.0 Ibs ai/A may be used. For the qranular formulation, the rate is 4.3 Ibs ai/A, except on cranberries, where B.I Ibs ai/A may be used. Usual carriers: Water is the most common carrier for liquid formulations. ------- —2— 1. Science T ’indinas : S .minarv science stat ent: th ical characteristics: Physical state: solid Qlor: urole Ck or: no data Va r pressure: not available and not required Meltinq çoint: 185°C (acid) and 234°C (sodii. i salt) Octanol/water partition coefficient: not available Stability: not stable above pM 9.5 or above 180°C. Tends to form the imide at elevated t nperatures. Solubility! Solvent Naptal Naptalam, Sod ium Water — 0.02 30.0 Acetone — 0.59 l.6R Xvlene — * 0.04 Benzene — * 0fl5 Rexane — * * thioroform — 0.01 * — 1.q4 5.53 nMq() — 4.31 140.0 Ether — 0.11 0.01 2—oropanol — ‘1.21 2. OQ MF ( — 0.37 o.c * Insoluble in this solvent. unusual handlina characteristics: Very hard water and water with l oM may cause precioitation of free acid F ran solution of naptalam sod iwt. May be incanoatible with sane pesticides. Riah electrolyte may be a robl n in mixtures with soluble fertilizers. ‘I xico1oqical characteristics: Acute Effects: Acute Oral tD ij — (rats) R.2 q/kq (naptalan), 1.7 a/kg (naptalan sodiun)(Cateqory IV) Acute Dermal W 50 - not available Acute Inhalation xicitv — not available Primary Eye Irritation — (rabbits) Cbrneal opacity in 3 of f animals: reversed in 4 of v animals at day 7. Coniunctival damaqe in 6 of 6 animals:, reversed in 3 of 6 animals at day 7. (Category 1) ------- —3-. Major Routes of ‘&posure: Dennal is the major route, followed by ocular and inhalation. Chronic ‘Effects: Oncogenicity — Mice : N ative at 5000 ppm, the highest dose tested. 1 ts : data gap ratology - Sprague-t wley rats: Increased maternal nDrtality and resorptions re noted at the mid dose level and above. MJEL for maternal and fetotoxic effects is therefore 15 mg/kg/day (lowest dose tested). Reproduction - data gap Mutagenicity — data gap Chranosomal Abberatlon — data gap Physiological and Biochenical Behavioral Characteristics: Tharislocatlon: 1’ en applied to soil, naptalain is absorbed by the roots and translocated to the leaves. Mechanian of Action: Blockaga of indoleacetic acid ( 1 IAA) action. ‘thvirorinental Characteristics: Absorption and leaching characteristics: Incomplete data indicate that naptalam is very n bile in a fine sand, a sandy loam, and a silt loan soil, and slightly n b11e in muck soil. Retention of naptalam by soil is correlated with CEC and organic matter content. The suth itted data are not sufficient to fill data requirenents. Microbial breakdown: Data gap Loss fran photodegradation and/or volatilization: t ta gap Resultant average persistance: Unknown Half-life in Water: Unknown. ‘Ecological characteristics: Hazards to Birds: Low toxicity, suggesting minimal hazards. Hazards to Fish and Aquatic ,Invertebrates: Low toxicity, suggesting minimal hazards. Potential Proble with ‘E dangered Species: 1 k ha7ards indicated. ------- —4— Tolerance Reassessment: List of crops and tolerances: (40 CFR 180.297) CJMMODITI (PPM) Cantaloups 0.1N Cranberries 0.1N Cucumbers 0.1N Mus) elons 0.1N Peanuts 0.1W Peanuts, hulls 0.1N Peanuts, hay 0.1W Soybeans 0.1N Soybeans, hay 0.1W Watermelons 0.1N List of food contact uses: Cantaloups, cranberries, cucumbers, muskmelons, peanuts, soybeans, watermelons. Results of tolerance assessment: No ADI can be set at this time. The k ency will reccrnmend that the negligible (N) classification be removed frcr all tolerances. 4. S .ntunary of Regulatory Position and Rationale : Use Classification: Not a restricted use pesticide. L .i toxicity. Groundwater Monitoring: Not required at this time. Data may be required later if warranted by environmental fate data. New Uses: The Agency will not approve new tolerances for significant new crops until data gaps regarding acute toxicity, teratogenicity, oncogenicity, plant and animal metabolism, storage stability, reproductive effects, and environmental fate are filled. Use, Formulation or Geographic Restrictions: Manufacturing—use products (of which there are none registered at this time) may only be formulated into end—use products intended for use as an herbicide on cucurbits, soybeans, peanuts, cranberries, or ody ornamental stock. Unique Label warning statements: 1. Use Pattern Statements : Labels of all MPs must bear the statement: “For formulation into end—use herbicide products intended only for use on soybeans, peanuts, cucurbits, cranberries, or ody nursery stock.” ------- —5— 2. Precautionary Statements Labels of MPS and EPs must bear the statements: a. Hazards to Humans Statements “DANGER: Harmful if swallowed. Corrosive. Causes irreversible eye damage. t not get in eyes or on clothing. Waar a face shield or goggles. Wash thoroughly with soap and water after handling and before eating or smoking. Remove contaminated clothing and wash before reuse.” and; b. Statements of Practical Treatn nt “ If in eyes : Flush with water for fifteen minutes. Call a physician.” “ If swallowed : Call a physician or Poison Control Center. Drink pra’rtptly a large quantity of milk, gelatin solution, or, if these are not available, drink large quantities of water. Avoid alcohol. NOTE TO PHYSICL N : Probable mucosal damage may contraindicate the use of gastric lavage.” C. Envirormental Hazard Statement The following specific statements must appear on the labels of all MP5: “tX. not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or public waters unless this product is specifically identified and addressed in a NPDES permit. Do not discharge effluent containing this product to sewer systems without previously notifyinq the sewage treatment plant authority. For guidance contact your State Water Board or Regional Office of the EPA.” The labels of EPs intended for outdoor use must bear one of the following statements, depending on the formulation of the product: Granular products must bear the statement: “Do not apply directly to water. In case of spills, collect for reuse or properly dispose of the granules. Do not contaminate water by cleaning of equi nent or disposal of wastes.” Non—granular products must bear the statement: “Do not apply directly to water. Do not contaminate water by cleaning of equipnent or disposal of wastes.” ------- -6- d. Grazing 1 strictions Stat nent The label of all EPS registered for use on peanuts must bear the stat nent: “Do not graze or feed forage or hay fran treated peanuts to 1 ivestock.” The label of all EPS registered for use on soybeans must bear the stat iient: “Do not harvest soybeans or soybean hay earlier than 90 days psttreathient. Do not graze or feed soybean forage or hay fran treated fields to livestock.” The labels of all products must bear the appropriate container disposal statenent. See pendix IV-4 of the guidance package. The required statements listed in the Standard must appear on the labels of all MPs and EPs released for shiq ent after March 1, l98 . The labels of all MPs arx3 EPS currently in the channels of traie nust be modified to inclir3e all the listed statements by March 1, 1987. After review of data to be subi ittec1 under the Standard, the Niencv may imtxse aiciitional labe] recuirements. 5. Stminary of malor data gaps Dates t en malor data gaps are due to be filled. Due date (Time allowed after publication of Data Required the Standard ) Description of beginning materials and manufacturing process twelve months Discussion of formation of unintentional inqredients twelve months Preliminary analysis of s nples six months Certification of limits six months ()3or six months Density, milk Density, or Specific Gravity six months Dissociation Constant six months PH six months Livestock metaboli n twenty-four months Plant metabolisn twenty-four months Storage stability data twenty—four months Maanit e of the residue for each food use twenty—four months cunulation Sttz3ies (confined rotational crops) twenty—four months (in fish) six months (in non-target aquatic orqani ns) six months Dermal ‘Ibxicity six months Inhalation ‘Ibxicity six months 90-day feeding (rodent, non-rodent) twelve months thronic toxicity four years Reproduction (2-generation) twenty-t months thraiosanal aberration ten months Other genotoxic effects (fl repair) ten months ------- —7— Data R auired tinder a Data Call—in Letter Sent October 1), 1984 Pzorox iJT ate IX1c? Date Hydrolysis Photodegradation (water, soil) Metaboli n sttxhes in lab Mobility studies - leaching and absorption/desorotion Dissipation studies in field (soil, water) Octanol/water partition coefficient cincogenicity Teratogenicity Water Solubilitv Vapor Pressure August 1, l98 August 1, 1985 P ve nber 1, 1987 August 1, 1985 ? Dvether 1, 1987 August 1, 1985 ? v nber 1, 1988 January 1, 1987 August 1, 1985 August 1, 1985 6. Contact person at EPA : bert Taylor, U.S. Envirom ental Protection Piency, TS—767—C, 401 M Street .J, Washington, DC 20460 (703) 557—l( 50 DISCLAIMER: The information oresented in this th nica1 Information Fact Sheet is for informational purposes only and may not be used to fulfill data requir nents for pesticide reaistration and rerecistration. ------- |