United States Office of Pertiddti and Toxic Sufartances
Environmental Protection Office of Petiiade Program* (TS-766C)
Agency Washington, DC 20460
v>EPA Pesticide
Fact Sheet
Name of Chemical: snmznqE
Reason for Issuance:
Date Issued: ^^ 30' 1984
Fact Sheet Number: 23
1. Description of the chemical
• Generic ns»e: 2-daaro^,*-bis(ethylaBino)-e-triarine
• Trade ranes: Algae-A-My, Algaecide, Algidize, Algi-eeter, Algi-gon
Andrine, Aquaxiner AtoadcMe, Cekusan, Cinarlrte, FTaned, Gesapun,
itop, Prisfltol S, Prinoep, Siaadex, Sn»nex, and Su»-trol.
tier; 0808H7
Service Registry Hunter (CAS) 122-34-9
Tear of initial registration: 1957
Pesticide type: Herbicide
^!s^&^xe^praducrrv * dbe-teigy Corporation, Griffin Corporation,
Chasical £peny. Inc., Dtvcsl Chadcs! Oa^any, and •——
2» Use patterns and fooBuletions
• Jtopiication aitest SiMsine ia registered for use as a selective or
nbn.ftUetive herbicide and algaecide. It is registered for use on
agricultural, noncrop, forest and aquatic sites.
• Mss^offoraiJlattosi Itettable poSr, granular, liquid, OcMble
3£aentrate, soluble eoootntrsta, dry nybto aitf liquid-ready to^use
• TVpes and sathods of appliestions: Biuedcast, band, soil incorporatea,
andsoil surface application using ground or aerial equipwnt.
The specific awthod of application and type of equipment are determined
by site, fonaulation, end egiitnMint availability.
0 Application rates: 1.6 Ibs. a.i.A to 9.6 Ibs. a.i./A, generally
4 Ibs. a.i.A-
0 Usual carrier: Water ,oil, and clay
3. Science f tndinos
Chemical cheracteristicst
• Stesine is a white, odorless, crystalline solid. It is •tableto heat
and tht Belting point is 225-227 C. Siaszine is nonflannable end does
not present unusual handling characteristics. Storage stability is
greater than three years at rcca temperature under dry_conditicns.
lexicological characteristics:
• Simarim is a coderate eye and dermal irritant (Toxicity Category III
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and has 1 ” oral and derl t clcitiec (‘t xlcity Category XV).
• There are no data availthle for ir* a1ati toxicity (A 1 ta Gap exists
for this requir..z.it).
• T i 1ogy Btt ies on s zine are as fU ’s:
— al L O in rats: > than 15,380 uig,lig body i i t
1*i.i..1 L 0 in rats: 10.2 sçlkg body
Irthalation in rats: No data .vail b1e for review.
— iin Irritation in r its: Slight irritant
Eye Irritati i in r Pthit$: 5 test anils after 72 sh d
derate irritation iid wes reversibla itt 7 days. No cwieal
qacity wes obeerved. ____
- Teratology in rats: No data available for rv iew. A data gap
exists for this re iir nt in 2 species.
— Three-Generation P rc ucticr St% y in rats: The reprc6icticn
pri is) 100 parts per ilhion (ppD). No adverse effects on
rejctive perfa r in rats at a dietary level of 100
for three gerarati over a total study period of 3 nks.
— rcmic feedjng/cnw Pa11iCity in rats: Oironic toxicity and ancopenic
potential z1 ’ t be dete ined in this study. A data gap exists
• for oncopenic or- s 1 ic toxicity in tk* rodent (rat).
— p aiic f.ethiç in dogs? Neither chro 4c t Uty mr cmocçenic
potential ild be dater ired fr this study. A data gap exists
for the dironic t tv1ty in i-rodents (dogs)
o oopenicity in aica: An cicogedcity study in a se rd species
is required.
— *itagenicity: P itagecdcity , ies were not available for review.
s exist for the entire category ci itaPgeniCity testing
required fox regiatsatfcn.
— General Netabolie ’ A data gap exists for a required general
eataboli study id i i identifies ar 1 quantitates tabal Ltes
in the q os e ci the ian species.
Whysiological aid biotheslcal behavioral characteristics:
Poliar a ition: Absorbed st1y thrwgh plant roots with little
or no foliar penetration. It has 1 ’ ac ering ability aid is
readily imahed frox foliage by rain.
— anslocation FoUoxirç r t absorption it is trans]ocated
acr eta11y in the xyles, acciia lating in the apical earist
id leaves of plants. ___
— Nediania. of pestiddal action: A photoxynthetic ith1bi bot
have a6 iticna1 effects.
Nstabo1i aid persistence in plants: Sbiezine is readily aetabolixed
by tolerant plants to hydroxysiaazine aid ino acid u njugates.
The bydr cySbDaZLI* can be further degragied by dealkylation of the
aide d aii aid by hydrolysis of resulting anino gruipa on the iing
____ prcd tion. ‘I ea alteratione of simazine are
aajcr protective d ani in acet tolerant and weed species.
Dialtered slaazine .c ruiIates in seneitive plants, causing chiorosis
- death.
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E,wi uJiEntal diaracteristics:
Msorptian le.thing in basic soil types: Str ’?ine is mare readily
a’ rbed on id cr clay soils than in soils of l clay ar 5 ary nie
tter tent. The d rd nt cr leathing of siaiazine is
ilaited by its lo” ter uolubility w . lao pticn to certain soil
a,netituants. Test have i m that icr several ths after surface
spplicaticn the test putUon wifl be fazd in the surface 2 indies
of soil.. It has little if aey lateral. a ., eient in soil t*zt cen be
imshed alcmg with soil particles.
— Ni bial breakd Ni cbIa1 re&cd i is one of several
pr sses thuolved in the degradati of simarine. In soils,
mi iJ4a1 a ivity pc*sibly . mts for de iticn of a
significant .mt of slaazine.
— li fran piotcde ositicn aid/or volatilization Uder n w l
cll tic conditions, loss of sfr 4rie soil by iota e osition
a,4/or volatilixat1a is cg nsidered ineignificant.
— Biosccuejlation Slaazlre has a ] potential to bio.eti .i ete
in fish.
— zl tent average pars istenost The average half-life of s 4 ’. .1ne
wder aMarobic soil c ditions is greater than 12 wedis.
half-life of simaslse wder aarthic soil ditla is S to 12
tcka. The pare lst e of á1z1z in p is dependent i
ear factees inchudiiç the level of algae aid weed infestation.
i age half-life for siii* in por is 30 days.
F , lc g(cal charact.riBtics
— vien oral tao: ) 4640 mg/Icg (practically tcn-t cic) ___
Mien dietary I 0: 2001) e to 111100 pp (soderately to sli t]y to ’ic )
Fish L 0 6.4 to 70.5 (soderately to slightly t ic)
uatic ini ertabt&ta L 0: 3.7 to 100 ppa (soderutely to .il tly t 1c)
— The i of silie a1 affect endangered e iatic species anly if
there wes a direct spplicatlan to the ister where they 6.elL
Terre tLibl endangered species sey be affected, partiaalerly for
audi uses as ditthihai*S aid rights-of-way. F >rr l conaultation
with the Office of Erdangered Species, flrE asy be initiated.
‘Iblerar asseI ntB
— Tolvraflcas have been established for eia.zir* in a variety of food
and forage orq s, east aid poultry, milk aid dairy prodects, aid shellfish.
11* eTEy has reccaluated the existing data base whidi revealed
significant deficiencies. Evaluation of aazte twicity data did not
reveal ar adverse aoute effects ci slaazine. Data are either laddng
or Insufficient to determine long-term dironic effects, oncogenicity
potentials, tirat nicity aid Ratagenicity. These data are crucial
and necessary for the contimiation of existing to1erar and for
the c msideratiui of additional tc1eian s. The inf .-. tion specifying
or differences beb.een aetabolites fQLP 4 in plants aid
anisels is also neoessary.
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Prthle %thith are b o m to have cca.irred with use of BIJ. ine:
— The files of the Pesticide Incident Monitoring SysteTt tPD ) ii icate
71 incidents involving s aazine wing the period 1966 to Jw’ie 1981.
Tt grwpe of reports re distingui&e6 in these incidents in
which alleged adverse effects e re ted. 0w gr ç containing
18 reports cited the invo1 rt of . aazine alaie. The other
itairwd 53 reports ad cited aii’ ’irw in c ’ination with ier
iiçredients. ft.eerw re involved in 13 incIdents in which sti’ina
alone cited as causing the alleged ad effects. 0* pe n
s P spit TI .d aid 12 re ived dica1 attention in these
iricid ta. ftanwis vere involved in 43 Incldants in which sI azirw
s cited in cjthirmtion with ott ingredients. Nine p 1e i re
h pitalissd, re than 35 received dical attention aid 412 i e
affected ce involved ad did ict seek sedicel advice in these
thc t
& ry of eciencw findings:
— Siaazirw is a derate eye aid dei 1 i itwit with l oral aid
d ’ 1 toxicities. * ava 41 le t 1 city data are ir affident
to fully ae5S the long-te chronie .ftecta or the orcogenic,
teratogenic, end autagenic potenl 4a1 of sii”1’e. 11* key data
gap for t eatid agrioi1tz al dities is tiw s .zine
eetabolites. Most established residue tolei.ii ws for’ agioalttaial
dities are e, essed In of the parent c xd only .
Ave 4 1 l. data ere ineufficiert to fully 5I the wj , t1
fate of slaixine ad the cm of ad ra*arget orgeni
to slzins. .vail 1 . . zIn. product. theslatry data are
i, afficiert to _ 1 the chesicel’. characteristics.
slth* is , t very ttw 4 c to mntarget ineects, birds, or estuerir*
aid aarine —.
4. &r ’ ry of regulatory position aid rationale
• All terrestrial use are R 1 ICr}1i; all other uses are classified
• No aejar use, fonmilaticri, ce ge 3 1 I ica] restrictice are requlx.
except for gr rdwater as ad 1ressad bel .
• No imique rning stat eflt$, protective clothing requiranents, t r
reentry interval stataieflts are required on the labeling; h ver, the
labeling aust bear the folloving grc*xd ster ocntaninaticei precautionary
tkP nPRr
‘Simazine is knom to leach thru.çh soil aid has been found in
grQxdwater. I ers are advised to a çly this product only where
grcun6mter *.ssinaticn is unlikely. Do tEt açly in recharge
areas c i designated Sole Source Aquifers, or in areas with we1 -
drained soils defined by Class A of the Soil Ccx servation Service
classification syatea which overlay ehal1 aquifers or which are
r protected by an overlying ispervicus layer. nsult the ver
state regulatory officials in your area for infonietion on the
location of sole source recharge areas, and the local agent of
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the Soil aiieiervat*a Servi for irt tia al y ir ecific
soil d arcteristi ..
No risk aeseenta ie u,nductsd.
5• of jcr data a ad these seja data p ’ axe ie to be
• available rt ad resi a diesistry data axe ir ifficin t to fully
j ] S $ d mctar 4 _eti . gter re.oeipt of guidarce padcage.
data iat be e tr 4 within 6 sonthe for rt t’ atidies within
4 eara for laç te atisiies. Laç beze stidies iJc1 de sI!’ I’ ad
its setabolites in at. silk, ,cultry. g aid other ix 1 ities .
• The avafl 1e t wlc1ty ta axe ii ifficisit to fully w the laç-
t” thrad.c ffectz at the a enic, tax t1ly”dC ad wtagenic
pct.nti. ’ of Bz . Vet. g . 1 .o axiste for a g.i m1 t oi.i
t dy in — ed.s. These st z1 4 t be r 4 ttad within 4
y xe aft ze elpt of aidar dc e. ___
• The follaiirç data axe i dz to fully a the envizcr ntal fate aid
txar t of, aid the p.AsflItial to . 1 4* (a) O-
dsridation etidies on soil t In (b) aax ic taboli
(a) .naaxthic aid aezQbIc a tet olLse (6) Ja.&irç aid adaa ptionir
(.) fi.ld diipstion s iv 4es tic._forestry art 3aiç-t (f) 1aUon
sb ies on zvtational ad irrigated a These ebdi.s t be
within the tise peri s ijdleated In T l . A, Gairric Vet. Nequi nt& for
54 4r , 158.130 wiru tal rate.
• ntact PersJ at A
Ritherd P. N mtfort
Pro act na er (23)
ivira ntal Pr ectIcn ency.-( - 767 C)
401 N Street, S.W
i ddsçta , D.C. 20460
(703) 557—38
DI .AD r The jnf tia 1 ie.entid in this diesical Infcn &tion Pact Sheet
is for j, 1 .-Ucnal parp es only ad sey rct be used to fulfill
data rs uix It$ for pesticide r istration ad reregistration.
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