United States Office of Pesticides end Toxic Subftaneci Environmental Protection Office of Pesticide Program* (TS-766C) Agency Washington, DC 20460 vvEPA Pesticide Fact Sheet Name of Chemical: Reason for Issuance: Date Issued: Fact Sheet Num July 16, 1985 iBer: 61 1. Description of Chemical Generic name: l-hydroxy-2(lH)-pyridinethione, sodium salt (CA) Common names: Sodium omadine Trade names: Sodium 2-pyridinethiol 1-oxide, Sodium 2-mercaptopyridtne, Sodium l-hydroxypyridine-2-thione, and Omadine* sodium. EPA Shaughnessy Code: 088004 Chemical abstracts Service (CAS) number: 15922-78-8 Year of initial registration: 04-10-68 Pesticide Family: Pyridine Pesticide type: Microbiocide U.S. and Foreign producers: Olin Corp., Research Center, 270 South Winchester Ave., P.O. Box 30275, New Haven, CT 06511 2. Use Patterns and Formulations Application sites: in metalworklng fluids, paints, inks, adhesives, plastics, laundry rinse additive, polymers, floor finishes. Types of Formulations: liquid formulations Include the following per- centages of sodium omadine: 4Z, 5Z, 5.9Z, 6.4%, and 40Z. Powder formulations include percentages 2Z and 90Z sodium omadine. Types and methods of application: for manufactured materials (i.e., plastics, paints, adhesives, etc.,), add at any point during the manufacturing process. As a preservative (i.e., in metalworking fluids, and inks) add directly to the solution to preserved. Application rates: for metalworking fluids use 4 - 1280 or./lOO Ibs. of fluid; for inks use 0.05 - 0.75Z of product/lb. of ink; for paints use 0.1 - 0.25Z of product/lb. of paint; for plastics and polymers use 0.1 -0.2Z of product/lb. of plastic or polymer. ------- —2— 3. Science Findings Summary of science statement: “bottom line” of science information listed below. Chemical Characteristics: Physical state: powder Solubility: 45.42 in water (25°C) Color: pale yellow 5.4% in ethanol Melting Point: between 252 — 257°C 19.12 in ethylene glycol 28.6% in methanol 3. Toxicology Characteristics: Acute Eye Irritation: Tox. CAT III Skin Irritation: Tox. CAT III Major routes of exposure: dermal and inhalation Chronic Toxicology: Teratology study (rat; dermal application): no teratogenic effects at 7 mg/kg/day. Teratology study (rabbit; dermal application): sodium omadine displayed dose—related maternal toxic effects and potental teratogenic effects at all dosage levels tested (0.5, 2.0, and 8.0 mg/kg/day). A NOEL could not be determined and malformations cannot be defined as teratogenic until effects are seen in the absence of maternal toxicity. Gene Mutation Study: no mutagenic effects noted at the highest dosage tested (25ug/plate [ activated) and 3ug/plate [ nonactivatedi). Environmental Characteristics: as there are no food/feed uses, or other outdoor uses, environmental fate data do not have to be submitted to the Agency. Ecological Characteristics: Avian Dietary Lc 50 (40% a.i. tested): Bobwhite quail 3246 ppm Mallard duck 9119 ppm Freshwater Fish LC5 (4% a.i. tested): Bluegill sunfish 66 ppm Rainbow trout 0.28 ppm Aquatic invertebrates LC 50 (40% a.i. tested): Daphnia magna 23 ppb ------- —3— Tolerance Assessments: the registered uses of sodium omadine do not include direct application to a food or feed crop. Therefore, no tolerances have been established for this chemical. No problems have been reported to the Agency (i.e., PIMS or data in reference to Section 6(a)(2) of the Act) with respect to the use of this chemical. 4. Summary of Regulatory Position and Rationale There are no use, formulation, manufacturing process or geographical restrictions for sodium omadine registrations. Unique warning statement: Environmental Hazards This pesticide is toxic to fish and freshwater invertebrates. Do not discharge effluent containing this product into lakes, ponds, streams, estuaries, oceans or public water unless this product is specifically identified and addressed in an NPDES permit. Do not discharge effluent containing this product to sewer systems without previously notifying the sewage treatment plant authority. For guidance contact your State Water board or Regional Office of the EPA. A risk assessment has not been conducted on this chemical. 5. Summary of Major Data Gaps Data Cap Date Study Due Acute Oral LD rj 12—31—85 Dermal Sensitization 12—31—85 Teratology (rabbit) 12—31—85 Mutagenicity Studies: Chromosomal 12-31—85 Other Mechanisms 123185 Reproduction — 2 generations 08—31—87 6. Contact Person at EPA Registration Division (TS—767C) U.S. Environmental Protection Agency Office of Pesticide Programs 401 M Street, S.W. Washington, D.C. 20460 Attn.: Marshall Swindell Telephone: (703)—557—3675 DISCLAIMER: The information presented in this Chemical Information Fact Sheet is for informational purposes only and may not be used to fulfill data requirements for pesticide registration and reregistration. ------- |