vvEPA
Unitad Statat
Environmental Pronction
Agency
Office of Pacticidai and Toxic Subctancas
Office of Pertiada Program (TS-766C)
W**nington. DC 20460
Pesticide
Fact Sheet
Name of Chemical:
Reason for Issuance:
Date Issued:
Fact Sheet Number:
"
30,
1. DESCRIPTION OF CHEMICAL
Generic Name:
Conunon Name:
Trade Names:
EPA Shaughnessy Code:
Chemical Abstracts
Service (CAS) Number:
Pesticide Type:
Year of Initial
Registration:
Chemical Family:
U.S. Producer:
2-(p-tert-butylphenoxy)cyclo-
hexyl 2-propynyl sulfite
Propargite
Omite®, Comite® and
Uniroyal D014
097601
2312-35-8
Acaricide
1966
Organosulfite
Uniroyal Chemical Company
2. USE PATTERNS AND FORMULATION
Application Sites; Terrestrial food crops (field, vegetable,
and orchard crops); terrestrial nonfood crops (ornamentals),
aquatic food crop (cranberry); and greenhouse nonfood crops
(ornamentals).
Types of Formulations: Single active ingredient (a.i.) formu-
lations consist of 4% dust; 3% and 30% wettable powders;
5, 6 and 6.55 pounds per gallon emulsifiable concentrates;
The technical formulation is 85% a.i., and the formulation
intermediate is 25% ct.i.
Types and Methods of Application: End-use product is applied
foliarly using air and/or ground equipment (including air
blast) .
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Application Rates : Application rate ranges from 0.75 to
6.75 lb active ingredient per acre.
Usual Carrier : Water
3. SCIENCE FINDINGS
Summary Science Statement : Propargite is not considered at
this time to be oncogenic. Propargite has a low acute
(Category III) oral, dermal, inhalation toxicity. It is
in toxicity category I however, for primary eye and primary
skin irritation, and cases of severe dermatitis afflicting
workers reentering treated sites have been reported.
Chronic testing reveals that propargite appears to have
little effect on laboratory animals except at higher
dosage levels; effects reported include depressed body
weights and rates of weight gain. Oral subchronic test
results appear to parallel those for chronic testing.
Propargite is not teratogenic in rabbits and rats. Insuf-
ficient data exist to fully assess the dermal sensiti-
zation, subchronic dermal toxicity, subchronic inhalation
toxicity, and mutagenicity of propargite. Additional
metabolism testing is also necessary. Propargite is
relatively nontoxic to honey bees and avian species. It
is very highly toxic to freshwater fish. The actual threat
to aquatic organisms at this time cannot be accurately
assessed due to the insufficiency of environmental fate
data. Field monitoring data to determine propargite
residues in water from terrestrial applications is needed
as is additional testing to determine the effects of
end—use products on coldwater and warmwater species of
fish, aquatic invertebrates, and estuarine and marine
organisms. The metabolism of propargite in both plants
and animals is not sufficiently understood; additional
metabolism data are necessary. Storage stability data
are also necessary, as well as additional crop residue
data and processing studies for certain crops registered
for propàrgite use.
CHEMICAL CHARACTERISTICS
Physical State: Viscous liquid.
Color: Dark amber
Odor: Faint solvent odor to very faint
solvent odor.
Density: Specific gravity = 1.085 — 1.115
at 25°C;
Bulk density = 40.92 lb/ft.
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Solubility: In water, about 0.5 ppm at 25°C,
miscible with organic solvents
such as acetone, benzene, and
ethanol.
Stability: No evidence of breakdown in one
year.
Flash Point: At least 38.5°C
TOXICOLOGICAL CHARACTERISTICS
Acute Effects
Adequate data are not available to fully assess the toxi-
city of Propargite. While, in general, propargite is not
highly toxic (Category III oral, derrnal and inhalation),
it is in toxicity Category I for primary eye and skin irri-
tation. Available data present only supplementary informa-
tion (as set forth below), and additional data must be
submitted.
Acute Oral Toxicity (Rat): 2.2 g/kg
Acute Dermal Toxicity
(Rabbit): 3.16(1.63—6.15) mi/kg
Acute Inhalation: > 2.5 mg/i
Primary Eye Irritation: Corneal effects that were not
reversible after 14 days were
observed in four of six rabbits.
Dermal Sensitization: Inconclusive
Subchronic Dermal
Toxicity: Inconclusive
Chronic Effects
Teratogenicity (Rabbit): Maternal NOEL = 2 mg/kg/day
Maternal LEL = 6 mg/kg/day
(reduced body weight gain)
Developmental Toxicity NOEL=
2 mg/kg/day; Developmental
(increased resorption,
reduced body weight, and
delayed ossification). A/D
ratio = maternal LEL/Develop-
mental = 2/2 = 1
3—Gen. Reproduction (Rat): NOEL > 300 ppm. Additional data
is required. Only one dose
used throughout the study.
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Mutagenicity: Inconclusive. Additional cate-
gories of mutageniCity testing
are required.
Chronic Feeding!
Oncogenicity (Dog): NOEL = 900 ppm (HDT). No
adverse effects were observed
by the hematology, blood
chemistry determinations or
urine examinations.
Feeding/Oncogenicity: Inconclusive. The study is
classified as Supplementary
because too few animals were
examined histologically at
900 and 2000 ppm. This study
needs to be repeated.
Metabolism: Inconclusive. Additional data
is required.
OTHER TOXICOLOGICAL EFFECTS
Propargite is not an organophosphate chemical; therefore,
it does not have a neurotoxic potential, and a neurotoxicity
study is not required.
MAJOR ROUTES OF EXPOSURE
There is a potential for dermal, ocular and inhalation expo-
sure from mixing concentrates and applying spray mixtures.
PHYSIOLOGICAL AND BIOCHEMICAL BEHAVIOR CHARACTERISTICS
Foliar bsorption: Data are not available to eval-
uate the effects of propargite
- in plants.
Translocation: Data are not available to evaluate
the translocation in plants.
Mechanism of Pesticidal
Actions: Mode of activity involves
residual killing action
ENVIRONMENTAL CHARACTERISTICS
Available data are insufficient to fully assess the environ-
mental fate of propargite. From the data that exists, however,
there seems to be no reason for concern about the leaching of
the parent chemical into groundwater.
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ECOLOGICAL CHARACTERISTICS
Avian Oral Toxicity:
Avian Dietary Toxicity:
Avian Reproduction:
Freshwater Fish Toxicity:
Aquatic Invertebrates
(freshwater):
Mallard duck — > 4640 ppm
•Bobwhite quail 3401 ppm
Mallard duck — > 4640 ppm
Data are inconclusive to deter-
mine the effects on avian
reproduction. Additional
data are required.
Bluegill Sunfish — 0.167 ppm
Rainbow trout — 0.118 ppm
Daphnia rnagna — 0.092 ppm
Aquatic Invertebrates
(lifecycle)
Daphia rnagna — 0.009 —
0.014 ppm
Available data indicate that propargite is practically nontoxic
to avian species. Propargite is highly toxic to fish.
TOLERANCE ASSESSMENT
Tolerances have been established
in raw agricultural commodities,
and meat by—products (40 CFR 180.
Commodity
Almonds
Almonds, hulls
Apples
Apricots
Beans, dry
Beans, succulent
CattreT fat
Cattle, MBYP
Cattle, meat
Corn, fodder
Corn, forage
Corn, fresh (md.
sweet) (K+CWHR)
Corn, grain
Cottonseed
Cranberries
Eggs
Figs (fresh)
for residues of propargite
milk, eggs, meat, fat
259)
0.1
55.0
3.0
7.0
0.2
20.0
0.1
0.1
0.1
10.0
10.0
0.1
0.1
0.1
10.1
0.1
3.0
Parts Per Million (ppm )
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Comniodity Parts Per Million (ppm )
Goats, fats 0.1
Goats, meat 0.1
Grapefruit 5.0
Grapes 10.0
Hogs, fat 0.1
Hogs, meat 0.1
Hops 15.0
Horses, fat 0.1
Horses, MBYP 0.1
Horses, meat 0.1
Lemons 5.0
Milkfat (0.08 in whole milk) 2.0
Mint 50.0
Nectarines 4.0
Oranges 5.0
Peaches 7.0
Peanuts 0.1
Peanuts, forage 10.0
Peanuts, hay 10.0
Peanuts, hulls 10.0
Pears 3.0
Plums (fresh prunes) 7.0
Potatoes 0.1
Poultry, fat 0.1
Poultry, MBYP 0.1
Poultry meat 0.1
Sheep, fat 0.1
Sheep, MBYP 0.1
Sheep, meat 0.1
Sorghum, fodder 10.0
Sorghum, forage 10.0
Strawberries 7.0
Tea (dry) 10.0
Walnuts 0.1
Results of the Tolerance Assessment : Because chronic feeding!
oncogenieity and reproduction studies are needed, the current
PADI is set on a 2—year dog feeding study a systemic NOEL
at the highest dose tested (900 ppm). At the highest dose
tested, there were no effects observed. With a safety
factor of 1000, the TMRC is currently 112% of the PADI.
The TMRC, however, is based on the assumption that 100% of
the crop for which a tolerance is established is treated with
propargite, which is not the case. If the TMRC is adjusted
to reflect the actual percentage of crop treated, the TMRC
would be reduced to a percentage level of the PADI signif i—
cantly lower than 112%. Therefore, the public should be in
no danger from dietary exposure while the Agency awaits data.
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SUMMARY OF REGULATORY POSITIONS AND RATIONALES
The following are warning statements that must be included
on propargite pesticide labels.
MANUFACTURING USE PRODUCTS
Under the Environmental Hazard Statement, add the following
precaution:
“This pesticide is toxic to fish. Do not discharge effluent
containing this product into lakes, streams, ponds, estu-
aries, oceans, or public water unless this product is
specifically identified and addressed in an NPDES permit.
Do not discharge effluent containing this product into
sewer systems without previously notifying the sewage
treatment plant authority. For guidance, contact your
State Water Board or Regional Office of the EPA.”
Protective Clothing Statement
“Mixer/loaders must wear goggles or a face shield, chemical—
resistant apron, long-sleeved shirt and long pants or
coveralls, and mid—forearm to elbow length chemical—resist-
ant gloves when mixing, loading, or otherwise handling
the concentrate.”
END-USE PRODUCTS
Products with Aquatic Use(s) : Under the Environmental Hazard
Statement, add the following precaution:
“This pesticide is toxic to fish. Do not apply directly to
watet except as specified on this label. Drift and runoff
from treated areas may be hazardous to aquatic organisms in
neighboring areas. Do not contaminate water by cleaning of
equipment or disposal of wastes.”
Products zith Terrestrial Use(s) : Under the Environmental
Hazard Statement, add the following precaution:
“This pesticide is toxic to fish. Do not apply directly
to water or wetlands (swamps, bogs, marshes, and potholes).
Drift and runoff from treated areas may be hazardous to
aquatic organisms in neighboring areas. Do not contaminate
water by cleaning of equipment or disposal of wastes.”
Reentry Statement (For All Products with Crop Uses )
“Do not allow worker reentry into treated fields within 3
days of application, for strawberries, and within 7 days,
for all other agricultural uses of propargite, unless
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appropriate protective clothing is worn. Protective cloth-
ing means at least a hat or other suitable head covering,
a long—sleeved shirt and long—legged trousers or a coverall—
type garment (closely woven fabric covering .the body,
including the arms and legs), chemical—resistant gloves,
socks, and shoes.”
Crop Rotation Statement
“Do not plant any food or feed crop in rotation within
6 months after last application of propargite unless
the crop is a registered use for propargite.”
Irrigated Crops Statement
“Do not use water leaving propargite treated fields to irri-
gate crops used for food or feed that are not registered
for use with propargite.”
Protective Clothing Statement
“Mixer/loaders must wear goggles or a face shield, chemical—
resistant apron, long—sleeve shirt, long pants, and
mid—forearm to elbow length chemical—resistant gloves.
Applicators must wear a long—sleeve shirt and long pants,
and chemical—resistant gloves while applying this pesticide.
Applicators must also wear a wide—brimned hat during
upward directed spraying.
Any article of clothing worn while applying product must be
cleaned before re—use. Clothing should be laundered separ-
ately from household articles. Clothing that has been
drenched or has otherwise absorbed concentrated pesticide
must be disposed of in a sanitary landfill, incinerated,
or burned if allowed by State and local authorities.”
- Endangered Species Statement (For Products with Use on
Terrestrial and Aquatic Food Crops, by February 1988 )
“The use.of any pesticide in a manner that may kill or
otherwise harm an endangered or threatened species or ad-
versely modify their habitat is a violation of Federal
laws. The use of this product is controlled to prevent
death or harm to endangered or threatened species that
occur in the following counties or elsewhere in their
range.
Before using this pesticide in the following counties, you
must obtain the EPA Cropland Endangered Species Bulletin.
The use of this pesticide is prohibited in these counties
unless specified otherwise in the Bulletin. The EPA Bulletin
is available from either your local pesticide distributor,
your County Agricultural Extension Agent, the Endangered
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Species Specialist in your State Wildlife Agency Head-
quarters, or the appropriate Regional Office of the
U.S. Fish and Wildlife Service (FWS). THIS BULLETIN MUST
BE REVIEWED PRIOR TO PESTICIDE USE. ”
5. SUMMARY OF MAJOR DATA GAPS
The following list presents data required and the due date
for submission of this data:
Product Chemistry Due Dates
Product Chemistry Feb 1987
Residue Chemistry
Plant/Livestock Metabolism Feb 1988
Plant/Animal Residues Feb 1988
Storage Stability Feb 1988
Toxicology
Sensitization Study July 1987
Subchronic Dermal Toxicity (21 days) May 1987
Subchronic Inhalation Toxicity (90 days) May 1987
Metabolism Sept 1988
Mutagenicity Sept 1987
Chronic Feeding/oncogencity Dec 1990
Two-Gen. Reproduction Dec 1989
Environmental Fate
Soil Dissipation (Field) Dec 1988
Aquatic (Sediment) Dec 1988
Rotational Crops (Confined) DeC 1989
Rotational Crops (Field) Nov 1990
Irrigated Crops Dec 1989
Fish (Accumulation Studies) Sept 1987
HydrolysTh/PhOtOdegradatiOrl July 1987
Aerobic Soil Metabolism Dec 1988
Anaerobic Soil Metabolism Dec 1988
Anaerobic Aquatic Dec 1988
Aerobic Aquatic Dec 1988
Leaching and
Adsorption/DesorptiOfl July 1987
Volatility (Lab) July 1987
Foliar dissipation (Reentry) Nov 1987
Soil Dissipation (Reentry) Nov 1987
Glove Permeability Nov 1987
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Summary of major data gaps (continued)
Ecological Effects
Residue Level Monitoring (Aquatic) Feb 1988
Avian Reproduction Sept 1988
Freshwater Fish (Warmwater) July 1987
Freshwater Fish (Coidwater) July 1987
Acute LC 50 Freshwater (Invertebrates) July 1987
Acute LC 50 Estuarine & Marine
Organisms (Shrimps) July 1987
(Fish) July 1987
(Mollusk) July 1987
6. CONTACT PERSON AT EPA
George T. LaRocca
U.S. Environmental Protection Agency
TS—767C
401 M Street, S.W.
Washington, D.C. 20460
(703) 557—2400
DISCLAIMER: The information presented in this Pesticide Fact Sheet
is for informational purposes only and may not be used to fulfill
data requirements for pesticide registration and reregistration.
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