United States Office of Pesticides and Toxic Subctances Environmental Protection Office of Pestiade Programs (TS-766C) Agency Washington. DC 20460 <&EPA Pesticide Fact Sheet Name of Chemical: Reason for Issuance: New Date Issued: Decatiber 1986 Fact Sheet Number: 105 1. DESCRIPTION OF CHEMICAL Generic Name: N-cyclopropyl-1,3,5-triazine-2,4,6 triamine Common Name: Cyromazine Trade Name: Larvadex® Technical and Premix (poultry feed through) Trigard® (celery and lettuce) EPA Shaugnessy Code: # 121301 Chemical Abstracts Service (CAS) Number: 66215-27-8 Year of Initial Registration: 1984 Pesticide Type: Insect Growth Regulator Chemical Family: Triazine Producer (U.S. only): Ciba-Geigy Corporation 2. USE PATTERN AND FORMULATION A. Application Site: Feed through for poultry - caged layers only. The active ingredient is passed through the chicken, leaving a residue in the manure that controls the growth of the fly larvae developing there. Type of Formulation: Premix - a coursely ground powder Application Rates: Mix 1 Ib of Larvadex (0.3% Premix) per ton of feed for control of housefly and soldier fly; for lesser housefly, mix 3.33 Ibs of Larvadex (0.3% Premix) per ton of feed. ------- B. Application Sites: Celery and lettuce Type of Formulationr Wettable Powder — this product is only packaged in 2 lb. water soluble bags Application Rates! One 2 lb. package mixed in the appropriate amount of water will treat 12 acres — this is 1/6 lb. Trigard 75W per acre. 3. SCIENCE FINDINGS Based on calculations and environmental chemistry data, there is no expectation for unreasonable adverse effects to riontarget organisms from the proposed uses of cyromazine. Sufficient data are available to support conditional registration of cyromazine as an insect growth regulator in and around poultry houses and for use on celery and lettuce. Chemical Characteristics of the Technical Chemical Physical state: crystalline solid Color: white Odor: odorless Boiling point: Not applicable Melting point! 220° to 222°C Flammability: Not applicable Solubility in water: 1.1% There are no unusual handling characteristics. Toxicology Characteristics Acute oral LD (rat); LD = 3387 mg/kg Toxicology Category III Acute oral LD (mouse); LD = 2029 mg/kg Toxicology Category III Acute oral LD (rabbit); LD = 1467 mg/kg Toxicology Category III Acute dermal LD (rat); LD >3100 mg/kg Toxicology Category III Primary dermal irritation (rabbit); P15 = 1.1/8.0 Toxicology Category IV 2 ------- Primary eye irritation (rabbit); Negative Toxicology Category IV Skin Sensitization (guinea pig): nonser.sitizing Toxicology Category: N/A Mutagenic (Salmonella); Negative for point mutations in TA1535, TA1537. TA98, TA100 with and without activation 90—Day feeding (dog); NOEL = 300 ppm: LEL = 1000 ppm: levels tested = 0, 30, 300, and 3000 ppm. 6 months feeding (dog); NOEL = 30 ppm; LEL = 300 ppm: levels tested = 30, 300 and 300 ppm. Teratology (rat); Negative for teratogeruc effects up to and including 1000 mg/kg/day. Teratology (rabbit); NOEL for teratogenic effects at 5 mg/kg/day: Maternal NOEL at 10 mg/kg/day. 2—Generation reproduction: Systemic NOEL = 30 ppm: systemic LEL = 1000 ppm: levels tested = 0, 30, 1000 and 3000 ppm. 2—Year feeding/Or.coger’.icity (rat): NOEL = 30 ppm: LEL = 300 ppm; negative for oncogenic effects at 3000 ppm (HDT). Mutagenic (dominant and nucleus): negative Physiological and Biochemical Behavioral Characteristics Mechanism of pesticidal action: Cyromazine is not a cholinesterase inhibitor. As an insect growth regulator, cyromazine exerts its toxic action by affecting the nervous system of the immature stages (larvae) of certain insects. Environmental Characteristics Cyromazine is practically nontoxic (acutely) to mammals and birds. Exposure estimates for these organisms are <0.05 ppm. Acute toxicity for birds is 1785 ppm maximum. Safety factor is 105_i06 for birds. Acute toxicity for mammals is 1000 ppm maximum. Safety factor is again 10 — 106. A summary of the environmental chemistry factors to be considered in this hazard assessment indicates that: 3 ------- o Cyromazine is stable to hydrolysis; photolysis is the dominant physico—chemical degradation mechanism. o Cyromazine is not expected to build up in soils; at 5 ppm in chicken manure (5 tons/A) <0.05 ppm cyromazirie is expected in soils. Half lives in soil—manure are 1 year (lab) and 12 weeks (field/greenhouse). o Cyromazirie is not expected to build up in plants or crops; <0.05 ppm is expected from typical chicken manure applications. o Cyromazine is not expected to build up in animal tissues; fish bioconcentratiori factors are expected to be between 0.2—7 .8X. o Cyromazine has no detrimental effects on soil microorganisms. o Cyromazine has a low to moderate mobility in Sandy or loam sand soils. Ecological Characteristics: Avian Acute Oral LD Species Mallard duck Bobwhite quail Peking duck Avian Dietary LC 50 Species Mallard duck Bobwhite quail LDç 0 >2510 mg/kg 1785 (1444—2206) mg/kg >6000 mg/kg >5620 ppm >5620 ppm 4 ------- Fish Acute LC 50 (96—hr) Species Bluegill sunfish Rainbow trout Channel catfish 96 hr LC >89.7 mg/i >87.9 mg/i >92.4 mg/i Aquatic Invertebrate LC Spec ies Daphnia magna hr Lç >97.8 mg/i Summary of Tolerances 40 CFR §180.414 Commod it ies Eggs Meat of Poultry Fat of Poultry Meat by—products of Poultry Poultry feed (see 21 CFR) Celery Lettuce Parts Per Million 0.25 0.05 0.05 0.05 5.0 10.0 5.0 4. SUMMARY OF REGULATORY POSITION Use classification: N/A Use, formulation or geographical restrictions: Larvadex has been approved for use in poultry feed for caged layers as a a feed through pesticide to control flies in the manure. Trigard has been approved for use or. celery and lettuce as a conventional spray on emulsion to control leafminers. Products containing cyromazine are to be stored in cool, dry places. There are no geographical restrictions or unique warning statments required on the label. 5 ------- 5. SUMMARY OF MAJOR DATA GAPS Toxicology: None Environmental Fate: Applicator Exposure Study Environmental Safety: None Residue Chemistry: None 6. CONTACT PERSON AT EPA Arturo E. Castillo, PM—17 Insectjcide—Rodentjcjde Branch (TS—767) 401 M Street SW. Washington, DC 20460 (703) 557—4414 DISCLAIMER: The information presented in this Chemical Information Fact Sheet is for informational purposes only and may not be used to fulfill data requirements for pesticide registration and reregistration. 6 ------- |