United States Office of Perticidei end Toxic Sufaetencw Environmental Protection Office of PestMMe Proorems (TS-766C) Agency Wellington. DC 20460 vvEPA Pesticide Fact Sheet Name of Chemical: Metoiachior Reason for Issuance: Registration Standard Date Issued: January, 1Q87 Fact Sheet Number: 106 1. Description of chemical Generic name: 2-chloro-N-(2-ethyl-6-methylphenyl) N-(2-methoxy-l-me thylethyl)acetamide Common name: Metoiachior Trade names: Dual, OGA-24705, Ontrack, Pennant EPA Shaughnessy code: 108801 Chemical Abstracts Service (CAS) number: 51218-45-2 Year of initial registration: 1976 Pesticide type: Herbicide Chemical family: Chloracetanilide U.S. producer: Ciba-Geigy Corporation, Agricultural Division (from active ingredient manufactured outside the U.S.) 2. Use patterns and formulations Application sites: For preemergence control of certain broadleaf and grassy weeds in terrestrial crop areas (corn, sorghum, cotton, potatoes, peanuts, soybeans, green beans, kidney and other beans, blackeye peas and other peas, stone fruits and tree nuts) and terrestrial noncrcp areas (ornamental plants, railroad, and highway rights-of-way). Types of formulations: 95% active ingredient (ai) technical grade manufacturing-use product. 5%, 15%, and 25% gram la rs, 86.4% emulsifiable concentrate, 27.5%, 31.8%, and 36.1% flowable concen- trate with atrazine; 36.3% flowable concentrate with propazine; and 73.6% emulsifiable concentrate with metribuzin. Types and methods of application: End-use product is applied by ground spray equipment, aircraft, or through center pivot irrigation systems. Application rates: 1.25 to 4 Ib metolachlor ai per acre (A) for terrestrial crop and noncrop areas. Usual carrier: Water, fluid fertilizers. 3. Science findings Summary science statement: -* Metoiachior is not considered to be teratogenic or cause reproductive effects. It is not oncogenic in mice, but is considered an oncogen in rats, and is tentatively classified as showing limited evidence of carcinogenicity in animals. Metoiachior is not mutagenic ------- 2 in available studies, bit mutagenicity and netaboli&n testing requir rents not in effect at the tine of issuance of the orginal MetolachlOr Registration Standard in 1980 imist be net. Metolachior has been found in several surface water surveys, sane tapwater samples, and in ground water in two States. Monitoring studies are required to determine the extent of contamination on a national scale. Metolachior is slightly to noderately toxic to nontarget organi . Available data are insufficient to assess the enviroriTental fate of rretolachlor. Chanical characteristics: Physical state: Liquid Color: White to tan Molecular weight: 238.8 Boiling point: 100 °C at 0.001 rrrnHg Solubility: 530 ppm in water at 20 °C, miscible with xylene toluene, dinethyl formamide, nethyl cellusolve, butyl cellusolve, ethylene dichloride, and cyclohexanone. Insoluble in ethylene glycol and propylene glycol. Vapor pressure: About i0 rrui g at 20 °C Toxicological characteristics: Acute effects: Acute oral toxicity (rat): 2780 mg/kg (Toxicity Category III — noderately toxic) Acute dermal toxicity (rabbit): > 10,000 mg/kg (Toxicity Category III — rroderate ly toxic) Acute inhalation toxicity: ) 1.752 mg/L with 4—hour exposure (Toxicity Category IV - non toxic) Primary eye irritation: Non—irritating Primary dermnal irritation: Non—irritating Dermal sensitization: Sensitizer in guinea pig Subthronic oral toxicity (dog): NOEL = 100 ppm (2.5 mg/kg) Decreased gain in body weight in males and females. Failure of the serum alkaline phosphatase to decrease with increased age, and possible effects on blood clotting syst ns at 300 and 1000 ppm. Chronic effects: 3—generation reproduction (rat): NOEL = 300 ppm (15 mg/kg) Reduced pup weights and reduced parental food consumption at 1000 ppm (50 mg/kg) ------- 3 Teratogenicity: Rabbits — Not fetotoxlc or teratogenic Maternal toxicity at high dose (360 n J1 g/day) Rats - Not fetotox c or teratogenic. Decrease in food consumption at high dose (360 mgJkgJday) in first third of study. Chronic feedigJoncogen city: Mice — Not oncogenic in two studies up to and including 3000 ppm (429 ng/kg) Rat - Systemic NOEL of 30 ppm (1.5 mg/kg). Systemic tEL of 300 ppm (testicular atrophy). In one study a stat1st cally sign f cant increase in primary liver neoplasms in females of’ high dose group (3000 ppm). In repeat study a statistically significant increased incidence of neop1ast c liver nodules and proliferative hepatic lesions in females of the high dose group (3000 ppm) Mutagenicity: Negative in an Ames Test, and a mouse dominant lethal test. Major routes of exposure: Dermal, ocular, arid inhalation from mixing concentrates and applying spray mixtures. Phys olog cal and biochemIcal behavior characteristIcs: Absorption: Generally applIed prior to plant emergence. Absorbed through shoots Just above seed and possibly roots. Mechanism of pestlcldal action: Member of group of’ chloracetarnlde herbicides whIch are general growth Irth bitors, especIally of root elongation. Metolachior may disrupt the integrity of plant cell membranes and inhibit lipId synthesis. Environmental characteristIcs: AvaIlable data are insufficIent to assess the envIronmental fate of’ metolachlor. There are indications that metolachlor Is essentIally stable ------- 14 in loamy sand soil over 614 days. Absorption constants in sandy clay loam, loam, and two sand soils indicate mobility in these SOilS. Aged metolachior 114 C residue was mobile in columns of loamy sand soil. Metolachior 114 C residues were mobile in sandy barns, sand, and silt loam soil. Metolachior l 14 C residues were detected in plants grown in metolachlor—treated soil. Metolachior has been found in several surfacewater surveys. Trans ient peaks of 1.2 to 14.1 1 ppb are reported in riverwater possIbly as a result of runoff during spring and summer. Detectable levels of metolachior were found in some tapwater samples. It has been found In ground water in two States. EcologIcal characteristIcs: Avian oral toxicity: Mallard duck > 2510 mg/kg Avian dietary toxicity: Mallard duck > 10,000 ppm BobwhIte quaIl > 10,000 ppm Avian reproduction: Mallard duck - showed no impaIrment at any test level — 1,000 or 10,000 ppm Bobwhi.te quail - NOEL = 10 ppm, impaIr nent at 300 ppm but no effect at 1000 ppm Freshwater fiSh toxIcIty: Bluegill sunfish — 10.0 ppm Rainbow trout — 3.9 ppm Aquatic invertebrates: Daphnla ma a — 25.1 ppm Fish life cycle: Fathead minnow - Maximum acceptable toxlcant concentratIon > 0.78 < 1.6 ppm Available data suggest that the hazard to nontarget organisms on an acute basIs Is sli.ght to moderate. Tolerance assessment: Tolerances have been establIshed for resIdues of metolachbor and its metabolltes in raw agricultural corrmoditles, milk, eggs, meat, fat, and meat byproducts [ 140 CFR 180.368(a)] as follows: Comodities Parts Per Million Almond hulls 0.3 Cattle, fat 0.02 Cattle, kIdney 0.2 Cattle, lIver 0.05 Cattle, meat 0.02 ------- 5 Caiinodities Parts Per Million Cattle, meat byproducts (mbyp) (except kidney and liver) 0.02 Corn, fresh (inc. sweet, kernel plus cob with husk removed) 0.1 Corn, forage and fodder 8.0 Corn, grain 0.1 Cottonseed 0.1 Eggs 0.02 Goats, fat 0.02 Goats, kidney 0.2 Goats, liver 0.05 Goats, meat 0.02 Goats, mbyp (except kidney and 1 ver) 0.02 Hogs, fat 0.02 Hogs, kidney 0.2 Hogs, liver 0.05 Hogs, meat 0.02 Hogs, mbyp (except kidney and liver) 0.02 Horses, fat 0.02 Horses, kidney 0.2 Horses, lIver 0.05 Horses, meat 0.02 Horses, mbyp (except kIdney and liver) 0.02 Legume vegetables group foliage (except soybean forage and soybean hay) 15.0 Milk 0.02 Peanuts 0.5 Peanut, forage and hay 30.0 Peanut, hulls 6.0 Peppers, chili 0.5 Potatoes 0.2 Poultry, fat 0.02 Poultry, lIver 0.05 Poultry, meat 0.02 Poultry, mbyp (except liver) 0.02 Safflower seed 0.1 Seed and pod vegetables (except soybeans) 0.3 ieep, fat 0.02 Sheep, kIdney 0.2 Sheep, liver 0.05 ------- 6 Carinodities Sheep, meat Sheep, mbyp (except kidney and liver) Sorghum, forage and fodder Sorghum, grain Soybeans Soybeans, forage and hay Stone fruits group Tree nuts group Parts Per M 11ion 0.02 0.02 2.0 0.3 0.2 8.0 0.1 0.1 Tolerances have been established [ 140 CFR 180.368(b)] for indirect or inadvertent residues of metolachior as a result of application of metolachior to the growing crops listed in 180.368(a) as follows: Comod t ies Parts Per MilliOfl Barley, fodder Barley, forage Barley, grain &ickwheat, fodder Buckwheat, forage &ickwheat, grain Millet, fodder Millet, forage Millet, grain Milo, fodder Milo, forage Milo, grain Oats, fodder Oats, forage Oats, grain Rice, fodder Rice, forage Rice, grain Rye, fodder Rye, forage Rye, grain Wheat, fodder Wheat, forage Wheat, grain 0.5 0.5 0.1 0.5 0.5 0.1 0.5 0.5 0.1 0.5 0.5 0.1 0.5 0.5 0.1 0.5 0.5 0.1 0.5 0.5 0.1 0.5 0.5 0.1 Canadian tolerances of 0.1 residues of metolachior in or on soybeans. No MexIcan tolerances Maximum ResIdue Limits have been metolachior. ppii have been establIshed for beans, corn, peas, potatoes, and or Codex Alirnentarius Canrnission established for resIdues of ------- 7 Results of tolerance assessment: Using the !sI3EL of 30 ppm (1.5 rng/kgJday) from the rat chronic feeding study and a safety factor of 100, the acceptable daily intake (ADI) is 0.015 rr g/kg/day, and the maximum permissible intake (MPI) iS 0.9 mg/day for a 60 kg person. The established tolerances result in a total theoretical maximum residue concentration (I!’IRC) of 0.0755 mg/day (1.5 kg diet) WhiCh corresponds to 8.38 percent of the MPI for a 60 kg person. 14• Sumary of regulatory positions and rationales UnIque label precautionary statements: Manufacturing-Use Products &ivlronmental Hazards Do not discharge effluent containing this product into lakes, streams, ponds, estuarIes, oceans, or public water unless this product Is specifically identifIed and addressed in an NPDES’ per’mlt. Do not discharge effluent systems without previously notifyIng the sewage treatment plant authority. For guidance, contact your State Water Board or Regional Office of the EPA. End-Use Products a. EnvIronmental hazards for emulsIfIable concentrates and flowable concentrates Lb not apply directly to water or wetlands (swamps, bogs, marshes, and potholes). Do not contaminate water by cleaning of equIpment or disposal of wastes. b. Environmental hazards for granules Cover or incorporate granules that are spIlled during loading or are visible on soIl surface in turn areas. Do not contaminate water by cleaning of equipment or dIsposal of wastes. c. Ground water and surface water advisory to1achlor has been Identified in limited sampling of ground water and there is the possIbility that it may leach through soils to ground water, especIally where soils are coarse and ground water 18 near the suface. Following application and during rainfall events that cause runoff, metolachior may * NatIonal POllUtiOfl Discharge Elminatlon System ------- 8 reach surface water bodies including streams, rivers and reservoirs. Care must be taken when using this product to prevent back Siphoning into wells, spills or improper disposal of excess pesticide, spray mixtures or rinsates. Check valves or antisiphoning devices imist be used on all mixing and/or irrigation equipment. d. Crop rotation statement Crops other than beans (succulent and dry), fresh corn, grain corn, cotton, peanuts, peas (succulent and dry), chill peppers, potatoes, safflower, sorghum, soybeans, stone fruits, tree nuts, and barley, buckwheat, millet, milo, oats, rIce, rye, and wheat may not be planted in metolachlor- treated soIl until 12 months after application e. Endangered species statements for products regIstered for crop uses It is a violation of Federal laws to use any pesticide in a mariner that results in the death of an endangered species or adverse modIfIcatIon of their habitat. The use of thIs product may pose a hazard to certain Federally designated endangered specIes known to occur in specifIc areas wIthin the CALIFORNIA counties of Merced, Sacramento arid Solario. Before using this product in these counties you must obtain the EPA Endangered Species Crop Bulletin. The bulletin Is avaIlable I rcxn eIther your County ExtensIon Agent, the Endangered SpecIes Specialist in your State Wildlife Agency Headquarters, or the RegIonal Office of either the U.S. FIsh and WIldlife Service (Portland, Oregon) or the U.S. Envirormiental Protection Agency (San Francisco, California). THIS BULLETIN MUST BE REVIEMED PRIOR ‘10 PESTICIDE USE. THE USE OF THIS H ODU IS PROHIBITED IN THESE COUN LES UNLESS SPECIFIED OTHE1 4ISE IN THE BULLETIN. 5. Suninary of data gaps (data requIred and due date) Toxicology Mutageniclty studies October 1987 General matabollam October 1988 Effects on coagulation April 1987 ** ** L te protocols are due. After acceptance, the Agency will provIde tlmeframe for SUb i8SiOfl of the reports. ------- 9 EnvIronmental fate Hydrolysis July 1987 Photodegradatlon studies July 1987 Metabolism studies January 1989 Mobility studies January 1989 Accumulation studies January 1990 Ground and surface water monitoring January 1987 ** Product chemistry/residue chemistry Product chemistry January 1988 Plant metabolism April 1988 Storage stability October 1988 Selected residue studIes April 1989 6. Contact person at EPA Richard F. Mountfort U.S. Environmental Protection Agency TS—767C Ziol M Street 34. Washington, DC 201460 (703) 557—1830 DISCLAIMER: The infor ation presented in this Pesticide Fact Sheet Is for informatIon purposes only and may not be used to fulfill data requirements for pestIcide registration and reregistratIon. ** L te protocols are due. After acceptance, the Agency wIll provIde time frame for suth ission of the reports. ------- |