United States Office of Peiticido and Toxic Sutatancw Environmental Protection Office of Pestiode Programs (TS-766C) Agency Washington. DC 20460 &EPA Pesticide Fact Sheet Name of Chemical: FENVALERATE Reason for Issuance: Registration update _ . . September 11, 1987 Date Issued: Fact Sheet Number: 145 1. DESCRIPTION OF CHEMICAL Generic Name: (S)-cyano (3-phenoxyphenyl) Methyl-(s)-4-chloro- alpha-(l-methylethyl) benzeneacetate Common Name: Penvalerate (BSI, ISO) Trade Names: Pydrin; Sumicidin; Belmark Other Names: S-5602; Sanmarton; SD 43775; Sumifly; Sumipower EPA Shaughnessy Code: 109301 Chemical Abstracts Service (CAS) Number: 51630-58-1 Year of Initial Registration: 1978 Pesticide Type: Pyrethroid-1ike; Insecticide/miticide Chemical Family: Pyrethroid Manufacturers: E. I. Dupont de Nemours; Sumitomo Chemical Co, Ltd (Japan) 2. USE PATTERNS AND FORMULATIONS Application Sites: Ftoliar treatments for control of various insect pests on agricultural crops, fruits, vegetables, ornamentals, lawns. Space and contact spray treatments in and around commercial and residential areas such as hospitals, supermarkets, motels, hotels, homes, transportation equipment (buses, boats, ships, trains, airplanes), utilities, food processing plants, restaurants and other food handling establishments, for control of common premise pests such as cockroaches, crickets, and ticks. Direct spray treatments for control of ectoparasites on pets, horses; cattle eartag; and spot treatment of fire ant mounds, and soil treatment for subterranean termite control in and around buildings and structures. ------- 2 Types of Formulations: E nulsifiable concentrates; liquids (ready—to—use), ready—to-use, and impregnated, and ULV concentrate. 3. themical/Physical tharacteristics of the Technical Grade Physical State: Liquid. ODlor: Clear viscous yellow Odor: Mild chemical odor Molecular weight and formula: 419.9 — C 25 H 22 C1N0 3 . Melting Point: Boiling Point: Density: 1.17 g/ml at 23° C. Vapor Pressure: 1.1 x 108 mmHg at 25°C. Solubility in various solvents: In H 2 0, <1 mg/i at 20° C. In acetone, chloroform, cyclohexane, ethanol, and xylene, >1 kg/kg at 23° C. In hexane, 155 g/kg at 23° C. Stability: Stable to heat and sunlight; stable to moisture; more stable in acid (pH 4) than alkaline solution. Ibxicology Characteristics of the Technical Grade — Acute Oral: LD 50 1—3 gms/kg for rat. — Acute Dermal LDSo for rabbit = 1—3 gms/kg — Primary Dermal Irritation (rabbit): none observed — Primary Eye Irritation (rabbit): none observed — Skin Sensitization (guinea pig): none observed — Acute Inhalation(rat); LC 50 > 101 gms/m3/4 hours — Subchronic oral: rat — NOEL = 125 ppm; dog — NOEL = 500 ppm (HDT) — Chronic Thxicity (rat): NOEL =250 ppm (HDT) ------- 3 lbxicology Characteristics of the Technical Grade (continued) — Chronic Toxicity (dog)*: NOEL = 200 ppm (HDT) — ( cogenicity (24 rronth — mice): systemic NOEL = lO—5Oppm, no oncogenic effects at 1,250p p m (HDT) — Teratogenicity: Teratogenic (mice) NOEL = 50 mg/kg/day (HDT); Teratogenic (rabbit) NOEL = 50 mg/kg/day (EDT) — Reproduction (3—Geri. Rat): NOEL = 250 ppm (HDT) — Mutagenicity (dominant lethal — mice): negative at 100 mg/kg, (EDT) — Host medicated — (Mice): Negative at 50 mg/kg (HDT) — Mutagenic — (Ames); Negative — Mutagenic — (Chinese hamster, bone merrow): Negative at 25 mg/kg *MO 70616 containing 75% of the active isomer (A—alpha) was tested in place of SD 43775 which contains 18% of its A—alpha isomer. Physiological and Biochemical Characteristics — The rtxx e of action in biological systems is stocnwh and contact, exhibiting neuropathological characteristics typical of pyrethroid insecticides. Slight repellarit effect. — F liar absorption: N/A — Translocation: N/A E vironmental Characteristics Adequate data are sufficient to define the fate of fenvalerate in the environment. nvalerate is stable to hydrolysis at environmental pH and temperature and to photolysis. In aqueous solutions exposed to ------- 4 E ivironmefltal tharacteristiCS (continued) natural sunlight, approximately 52% of the parent compound degraded with a calculated half—life of 41 days. In the laboratory, in soil maintained under aerobic conditions the half—life ranged from 65 days to 8 months, in soil maintained under anaerobic conditions the half life was approximately 6 months. In colunr —leaching studies where fenvalerate was applied to different soil types and then saturated with water, results indicated that fenvalerate and aged degradation products were relatively in obile. Field studies indicate that residues of fenvalerate remain in the 0—4 inch layer with a half—life of 1—2 months. After 183 days, residues were at negligible or undetectable levels. Confined and field rotational crop data show that residues of fenvalerate are likely to occur in root crops at intervals of less than nine months. Bioaccumulation factors of 400X were found in edible portions of rainbow trout after exposure for 30 days. Depuration was relatively slow with about 40—60% of the residual activity remaining after 33 days and virtually all as intact parent compound. In catfish, with a bioaccumulation factor of 62X the depuration was also slow with a half—life of 46 days in whole fish. Ecological Effects tharacteristics — Avian acute oral LDSo (Mallard): CD 50 = 9,932 mg/kg. — Avian dietary CC 50 (Bobwhite quail): CC 50 > 10,000 ppm. — Avian dietary CC 50 (Mallard): CC 50 = 5,500 ppm. — Fish acute 96—hour CC 50 (Bluegill sunfish): CC 50 = 0.42 ppb. — Aquatic invertebrate acute 48—hour CC 50 (Pink shrimp)*: (96—hour) EC 50 = 1.4 ppb. ------- 5 Iblerance Assessments The maximum prem.issible intake (MPI) was calculated using the rat no—observable effect level (NOEL) of 50 ppm, which was determined in a subchronic (13—week) feeding study. The study was conducted with MO 70616 which containing 75% of the active isomer (A—alpha) instead of the ) 43775 which contains 18% of its A—alpha isomer. This NOEL is equivalent to 2.5 mg/kg/day. A safety factor of 100 results in a calculated acceptable daily intake (ADI) of 0.025 mg/kg/day and an MPI of 1.5 mg/kg/day for a 60 kg human. No additional data are required to support the current crop tolerances listed in 40 CFR 8180.379 Summary Science Statement — Fenvalerate, a synthetic pyrethroid is toxic to wildlife and extremely toxic to fish. It is. higly toxic to bees exposed to direct treatment on blooming crops or weeds. Fenvalerate has low toxicity to mammals. A 24—month feeding/oncogenic (rat) study demonstrated that fenvalerate is not oncogenic. Mutagenicity data indicate that fenvalerate was negative for all mutagenic tests conducted. Fenvalerate is inmDbilized in soils. The aged degradation products of fenvalerate do not leach significantly in a sandy loam soil column. It degrades in the soil under field conditions. At this time, there are no concerns for ground- water contamination. 4. Su’nmary of Major t ta Caps — Freshwater invertebrate life—cycle test — Estuarine invertebrate life—cycle test — Simulated and/or actual field study ------- 6 5. Surrunary of Tblerances Issued for Fenvalerate Cbmmodity Parts per million Almond hulls 15.0 Almonds 0.2 Apples 2.0 Artichokes 0.2 Beans, dried 0.25 Beans, snap 2.0 Broccoli 2.0 cabbage 10.0 cantaloupes 1.0 Carrots 0.5 Cattle, fat 1.5 Cattle, nbyp 1.5 Cattle, meat 1.5 Cauliflower 0.5 Collards 10.0 Corn, grain 0.002 Corn, fodder 50.0 Corn, forage 50.0 Corn, sweet, kernels & cobs 0.1 Cottonseed 0.2 Cucumbers 0.5 Eggplant 1.0 E iglish walnuts 0.2 Filberts 0.2 Goats, fat 1.5 Goats, rthyp 1.5 Goats, meat 1.5 Hogs, fat 1.5 Hogs, mbyp 1.5 Hogs, meat 1.5 Honeydew melons 1.0 Horses, fat 1.5 Horses, mbyp 1.5 Horses, meat 1.5 Milk 0.3 Milk, fat 7.0 Muskmelons 1.0 Peanuts 0.002 Peanut hulls 0.10 Pears 2.0 Peas 1.0 Peas, dried 0.25 Pecans 0.2 Peppers 1.0 ------- 7 5. Summary of Thierances Issued for Fenvalerate (continued) Cbmmodity Parts per million Potatoes 0.02 Pumpkins 1.0 Radish, roots 0.3 Radish, tops 8.0 Sheep, fat 1.5 Sheep, ntyp 1.5 Sheep, meat 1.5 Soybeans 0.05 Stone fruits 10.0 Sugarcane 2.0 Sun er squash 0.5 Sunflower seed 1.0 Tbmatoes 1.0 Watermelons 1.0 Winter squash 1.0 6. Cbntact Person at EPA George T. LaRocca Product Manager 15 Insecticide—Rodenticide Branch Registration Division (TS—767C) Office of Pesticide Programs &ivironmental Protection Agency 401 M Street, S.W. Washington, DC 20460 Off ice location and Telephone No. — Room 204, Crystal Mall #2 — 1921 Jefferson Davis Highway — Arlington, VA 22202 — (703) 557—2400 ------- |