United States
Environmental Protection
Agency
Office of Pesticides and Toxic Substances.
Office of Pesticide Programs (TS-766C)
Washington, DC 20460
540/FS-88-088
v>EPA Pesticide
Fact Sheet
Name of Chemical: cyf luthrin
Reason for lssuance:Unconditional Registration
Date Issued: December 30, 1987
Fact Sheet Number: 164
DESCRIPTION OF CHEMICAL
Generic Name: Cyfluthrin (Cyano (4-fluoro-3-phenoxyphenyl)
methyl 3-(2,2-dichloroethenyl)-2,2-dimethyl
cyclopropanecarboxylate
Common Name: Cyfluthrin
Trade Name: Laser
EPA Shaughnessy Code: 128831-5
Chemical Abstracts Service (CAS) Numbers: 68359-37-5
Year of Initial Registration: 1987
Pesticide Type: Insecticide
Chemical Family: Synthetic pyrethroids
U.S. Producers: Mobay Chemical Company;
Miles Laboratories, Inc.
USE PATTERNS AND FORMULATIONS
Application Sites: General indoor and domestic outdoor
(ornamental areas)
Method of Application: localized spot treatment,
crack and crevice and space sprays
Formulation Types:
a) Laser Ant and Roach Killer
0.1% Cyfluthrin
1.0% Piperonyl Butoxide
0.05% Pyrethrins
b) Laser Flying Insect Killer
0.04% Cyfluthrin
0.72% Tetramethrin
1.00% Piperonyl Butoxide
c) Laser Flea Killer Spray
0.01% Cyfluthrin
0.8% Chlorpyrifos
2.5% Pyrethrins
1.0% Piperonyl Butoxide
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d) Laser Ant and Roach Killer II
0.10% Cyfluthrin
1.00% Propoxur
0.25% Pyrethrins
1.00% Piperonyl Butoxide
e) Laser House and Garden Multipurpose
Insect Killer
0.04% Cyfluthrin
0.35% Tetramethrin
1.00% Piperonyl Butoxide
Application Rates: 0.04 and 0.1% sprays
Usual Carriers: organic solvents; water
Limitations: For Domestic Indoor and Outdoor
Use Only
3. SCIENCE FINDINGS
Summary Science Statement :
Technical cyfluthrin does not exhibit high mammalian
toxicity. It is not considered to be mutagenic or
teratogenic and is not a skin sensitizer. The results
of the acute toxicity on the domestic use formulations
indicates that the chemical is of low toxicity. Cyfluthrin
has been tested in several studies (rat, mouse, chicken,
dog) for possible delayed type neurotoxicity and has been
shown to be neurotoxic when administered at relatively
high dosage levels under certain conditions. However
the neurotoxic dose levels were considerably higher
than those which elicited other signs of toxicity
indicating that cyfluthrin should not exhibit delayed
type neurotoxicity under conditions of use. Chronic
feeding and oncogenic studies indicate that cyfluthrin
is not an oncogen.
Sufficient data are available to characterize cyfluthrin
from an environmental fate and ecological effects standpoint.
Cyfluthrin is extremely toxic to fish and aquatic organisms
but is practically non—toxic to upland game birds and
waterfowl. An acute contact LD 50 study indicated that
cyfluthrin is toxic to the honey bee with an LD 50 = 0.037
mg/bee. Cyfluthrin undergoes rapid photolysis, is readily
degraded by soil and is relatively insoluble in water.
There is little or no potential for leaching.
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A tolerance assessment is not needed because the
registered use pattern is for non—crop/non—food use.
There are no data gaps.
Chemical/Physical Characteristics of the Technical Material
Physical State: liquid
Color: dark amber
Odor: aromatic solvent odor at room teniparature
Melting Point: not applicable
Vapor Pressure: 2.1 x 10—8 mbars
Density: 0.830 + .005 g/ml
Soiubiiity: 0.002 mg/mi at 20°C in water
pH: 5.6
Octanol/Water Partition Coefficient: 4.2 x
Toxicological Characteristics:
Technical Cyfiuthrin
Acute Oral (Mouse): males: 291 mg/kg Toxicity Category II
83.6% females: 609 mg/kg
Acute Dermal:
LD 50 > 5000 mg/kg Toxicity Category III
21—day Dermal (rat):
LD5O > 5000 mg/kg Toxicity Category III
Primary Dermal Irritation (rabbit):
none observed Toxicity Category IV
Skin Sensitization (guinea pig):
not a sensitizer
Acute Inhalation: LC 50 (4 hour) males — >0.735 mg/i
females — 0.200 — 0.735 mg/i
Teratology: (rat) Maternal NOEL = 3 mg/kg/day
Maternal LEL = 10 mg/kg/day
Fetotoxic NOEL = 30 mg/kg/day
Teratogenic NOEL = 30 mg/kg/day
2—Year Feeding/Oncogenicity: (rat) Oncogenic NOEL = 22.5 mg/kg/day
Systemic NOEL = 2.5 mg/kg/day
Systemic NOEL = 7.5 mg/kg/day
Gene Mutation: negative
Structural Chromosome Aberration: negative
Unscheduled DNA Synthesis: negative
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Laser Formulations
,Acute Oral Toxicity in rats: Toxicity Category IV
LD 5 0 = >5000mg/kg
Acute Dermal Toxicity in rats: Toxicity Category III
LDS0 = >2000mg/kg
Acute Inhalation: Toxicity Category IV
LC 50 = >5mg/i
Primary Eye Irritation: Toxicity Category IV
Primary Dermal Irritation: Toxicity Category IV
PIS = 0.9
Dermal Sensitiztion: not a sensitizer
C. Physiological and Biological Characteristics
The mode of action in biological systems is stomach and
contact exhibiting neuropathological characteristics typical
of pyrethroid insecticides. Slight repellant effect.
Foliar absorption: N/A
Translocation: N/A
D. Environmental Characteristics
Adequate data are sufficient to define the fate of cyfluthrin
in the environment. Cyfluthrin is stable to hydrolysis
at environmental pH and temperature and to photolysis.
It photodegrades rapidly with a half—life of <2days at ph
9. The major degradate is 4—f luoro—3—phenxyl—benzaldehyde
Under the conditions of the soil TLC test using various
soils, (aged and unaged) cyfluthrin residues are considered
immobile in soils with a half—life of 56 to 63 days in
German loam and sandy loam, respectively. Anaerobic
conditions did not alter either degradation rate or
products. Cyfluthrin’s solubility in water is determined
to be 2ppb (20°C). It has a bioaccumulation factor in
fish of 858x. Residues are depurated radidly in untreated
water. Accumulated residues are found in non—edible
tissue. Cyfluthrin and its degradates do not leach into
the soil. There are no concerns at this time in regard
to ground water.
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E. Ecological Characteristics
Avian Acute Oral: Bobwhite quail — LD 50 > 2000 mg/kg
Avian Subacute Dietary: Mallard duck — LC 50 > 5000 ppm
Bobwhite quail - LC 50 > 5000 ppm
Freshwater Fish: Bluegill — LC 50 = 1.5 ppb
Rainbow Trout — LC 50 = 0.68 ppb
Freshwater Invertebrate: Daphnia magna LC 50 = 0.14 pptr
Marine/Estuarine Invertebrate: Mysid shrimp — LC 50 = 2.42 pptr
Eastern Oyster EC 50 = 3.2 pptr
Marine/Estuarine Fish: Sheepshead minnow — LC 50 = 4.05 ppb
4. Summary of Regulatory Position and Rationale
The Agency has determined that it should allow the
registration of cyfluthrin for domestic indoor and outdoor
use for control of household pests, such as fleas,
cockroaches, garden insects. Adequate data are available
to assess the acute toxicological effects of cyfluthrin to
humans. Since no crop, food or feed uses are proposed, a toler-
ance assessment is not necessary. As is typical of synthetic
pyrethroids, technical cyfluthrin is highly toxic to aquatic
organisms (invertebrates and fish). However, the proposed use
patterns should not pose any environmental hazard. None of the
criteria for unreasonable adverse effects listed in section
162.11(a) of Title 40 of the U.S. Code of Federal Regulations
have been met or exceeded for this use.
5. Summary of Major Data Gaps
There are no data gaps for the domestic indoor/outdoor use.
6. Contact Person at EPA
George T. LaRocca
Product Manager (15)
Insecticide—Rodenticide Branch
Registration Division (TS—767C)
Office of Pesticide Programs
Environmental Protection Agency
401 M Street, S. W.
Washington, D. C. 20460
Office location and telephone number:
Room 211, Crystal Mall #2
1921 Jefferson Davis Highway
Arlington, VA 22202
(703) 557—2400
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