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                                         Washington  OC  20460
&EPA       Pesticide
                    Fact Sheet
                    Name of Chemical.   Command
                    Reason for Issuance  «ew chemical
                    Date Issued:  June ?o,  198-
                    Fact Sheet Number: 9o.i
 BACKGROUND

 o This fact sheet addresses reports of phytotoxicity resulting from the  use of

   Command, a herbicide manufactured by FMC Corporation.  Conmand was registered

   oy tne Agency as a new chemical in February, 1986 for use on soyoeans  to control

   a broad spectrum of broadleaf and grassy weeds.  The herbicide is marketed as

   two end-use products; a 4EC  (Reg. No. 2793053) and a SEC (Reg.  Nc.  279-3054).

 o The Agency has a conplete data base for the chemical which shows very  little

   potential for acute or long  term health effects.   However, because the adjuvants

   (inert ingredients) used in  the formulated product can cause irreversible eye

   damage, the 6EC laoel Dears  the signal word danger.

 o Phytotoxicity data indicate  that sane desirable plants are sensitive to Command

   and some off-target injury could occur.  Because  of  this potential for injury

   to non-target plants, statements regarding chlorosis or bleaching of sensitive

   plants growing in proximity  of treated fields are declared on tne laoel.  The

   Command product label states: "Sane desirable plants, including ornamentals

   (e.g., roses), trees (e.g.   flowering and edible  cherries), agronomic crops

   (e.g., small grains, alfalfa, sunflowers) and vegetables (e.g., lettuce, cole
                                                  X
   crops, radish) are sensitive to Command herbicide.   Foliar contact with spray

   drift or vapors may cause visual symptoms of chlorosis or bleaching to sensitive

   plants growing in the proximity of treated fielas.   These symptoms are temporary.

   Extra caution is advised when spraying near desiraole plants found in residential

   or otner cormercial airicultura'  clantincs."

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PHYTUTOXIC PROBW
o The Agency has received numerous reports frc several midwestern states
in Region V & VII of d nage to non—target plants when Cairgnand is applied to
soybean fields as either a surface or soil incorporated treatment. Sane of
this damage is beyond the proximity of the treated field. Apparently, the
chemical quickly volatilizes and IrKves frai the treatment site to nontarget
plants where it causes chlorosis (whitening) in plant foliage. This effect,
in nost cases, appears to be temporary. Reports irc state officials indicate
that the product was used according to label directions.
DIETARY EXPOSURE PROFILE
o C ivnand is not oncogenic or teratogenic. The Acceptable ily Intake is
based on a NOEL of 100 pç n (4.3 u /kg/day) in a 2 year rat feeding study witr
a safety factor of lOG.
o Information suthutted by the registrant do not show any detectable residues
in non—target crops such as leaty vegetables (lettuce, spinach, kale, rhuDarb,
chinese cabbage), fruiting vegetables (peas, beans, tai atoes), root crops anc
fruits. Residues have been detected at levels up to 1.4 ppn in alfalfa and
pasture hay.
o The registered use and tolerance on soybeans at 0.05 p uses 0.3% of tne
AD. Even if every food item in the total diet had residues of .05 pçzr
only approximately 3% of the ADI would be used.

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o The Agency does not have adequate data on the nature or magnitude in meat or
milk fran residues in feec. However, metabolism studies in rats snow tna .
Catinand was excreted rapidly (90-99% within 72 hours) with no significant
retention in rats tissues. This, together with the structure of the chemical
and other information indicate that signifi ant bioacc .unulation in edible
tissues or milk is unlikely.
EPA )SITICN
o The Agency has worked with RIC, regional personnel and state officials to
determine the scope of the problem. EPA will be reviewing additional in-
formation as it becanes available and will be assessing this situation as
to what can be done to address the off—target problem and related issues
prior to the 1987 growing season.
o Since residues were detected in alfalfa and hay, the Agency will be dig-
cussing tne matter with the Food and Drug A iinistration. However, on the
oesis of the available information, the Agency concludes that direct human
consulTç)tion of the affected crops, or the feeding of affected forage iterr
to animals, will not pose an unreasonable risk to the public.
o Off-target movement of Ccznnand is not expected to cause any adverse health
effects to persons in the vicinity of treated areas.
(Contact Frank Sanders 557—1650 or Robert Taylor 557—1800)

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