IMttad Stalt* offiea of Pattlddai and Toxfe Sufartaneai
Envirannwntil Protection Offica of Panietda Programs (TS-766C)
Agency Washington, DC 20460
xvEPA Pesticide
Fact Sheet
Name of Chemical: FENDXYCARB
Reason for Issuance: REGISTRATION STANDARD / NEW CHEMICAL
Date Issued: Feb.i, 1986
Fact Sheet Number: 78
1. Description of Chemical
Generic Name: (Ethyl[2-(1-phenoxyphenoxy)ethyl] carbamate)
Common Name: fenoxycarb
Trade Names: Logic, Ro 13-5223
EPA/OPP Chemical Code (Shaughnessy Number: 128801
Chemical Abstracts Service (CAS) Number: 72190-01-8
Year of Initial Registration: 1985
Pesticide Type: Insectlclde/Mltlcide
U.S. and Foreign Producers: MAAG Agrochemicals
2. Use Patterns and Formulations
Fenoxycarb Is registered for use as a bait to control
fire ants In or on turf, lawns, and nonagrlcultural land
such as airport turfs, parks and golf courses.
Applications are made as single mound (1 to 3 level
tablespoons/ mound) and broadcasting (apply uniformly
with ground equipment calibrated to give correct dosage
[1 to 1.5 lb/A]).
Fenoxycarb Is formulated as a 1.0 percent bait.
3. Science Findings
Summary Science Statement;
Fenoxycarb Is an Insect Growth Regulator (IGR) which
Is moderately acutely toxic to human and other nontarget
terrestrial organisms. Fenoxycarb Is highly toxic to
aquatic Invertebrates. The current No Observable Effect
Level (NOEL) Is based on a rat 52-week Interim report,
which satisfies the requirement for a rat 90-day feeding
study. Available data are sufficient to fully assess
the toxicology of fenoxycarb for the subject use pattern,
Its fate In the environment, and the exposure of humans
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and nontarget organisms to the chemical or its
degradates. Environmental fate data reqiurements has
been satisfeid with the exception of soil photolysis
(data gap).
Chemical Characteristics :
Technical fenoxycarb is a light brown lumpy powder,
stable under normal conditions. Slight hydrolysis occurs
in aqueous solution at pH 3,7, and 9 at 35°C and 50°C
for period of time up to 70 days. It is very soluble
(250 g/l solvent) in most organic solvents(e.g., acetone,
chloroform, diethyl ether, diethyl formamlde, ethyl
acetate, methanol, toluene) hexane. It is slightly
soluble In hexane(5 g/l solvent).
Toxicological Characteristics :
Fenoxycarb Is moderately toxic (Tox. Category III
from acute oral arid derma]. routes of exposure).
Toxicology studies on fenoxycarb are as follows:
— Oral LD 50 in rats: LD 50 > 16,800 mg/kg
— Dermal LD 50 in rats: LD 5 > 5000 mg/kg . -effects
included dysprlea, curved
body position, ruffled fur,
sedation, diarrhea. No
deaths occurred.
— Metabolism study In rats: 90—92% excreted in 96
hours. Organs did not
show persistent residues.
- Rat 52-week Interim Report: NOEL = 200pprn
- Teratogenicity: Terato enic effects were not
observed at dose levels up to
300 mg/kg/day which was the
highest dose tested.
- Mutageriicity: Nonmutagenic
- Derinal sensitization: Not sensitizing
- 21—Day dermal: NOEL = 200mg/kg/day(slight erythema;
elevated liver weight at top dose)
Physiological and Biological Character18tIcs
Fenoxycarb is an insecticide that disrupts the
development of the pest. Penoxycarb has an insect
specific mode of action exhibiting strong juvenile hormone
activity. It inhibits metamorphosis to the adult stage,
induces Interference with the molting of early instar
larvae, and produces certain ovicide and delayed larvicide/
adulticide effects in various insect species.
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Environmental Characteristics :
Fenoxycarb is stable to hydrolysis at pH 3-9 and
temperatures up to 50 °C. However, fenoxycarb is
expected to photodegrade in pure and natural water with
a half—life of’ 5 hours.
Field studies indicate that under exaggerated and
normal use conditions dissipation of’ fenoxycarb in soil
is rapid; resldue8 are no longer detectable 3 days after
application.
Soil column studies using fresh and aged aoils
indicate a low potential for leaching. Adsorption/
desorptlon studies indicate moderate to strong soil
binding. Fish exposed to fenoxycarb In water will bio—
accumulate fenoxycarb to concentration 300x greater
than the concentration in the water. However, the fish
will release 99% of the residues within 2 weekss when
placed in water containing no fenoxycarb.
Ecological Characteristic :
Avian Oral LD 50 = > 3000 mg/kg (mallard ducks)
Avian Dietary LC 50 = 11574 ppm (bobwhite quail).
Data show that fenoxycarb is
practically nontoxic to birds.
Fish LC 50 = 1.6 ppm for rainbow trout and 1.86 ppm
for bluegill. Data show that fenoxycarb
is moderately toxic to fish.
Data submitted indicate that fenoxycarb is low to
moderate in toxicity to honeybees. Bee hazard is
decreased because the pesticide will be formulated as a
grit or corncob bait, which will result In little or no
bee exposure. Thus, currently registered uses of’ the
formulated product should present no hazard to bees.
It Is unlikely that the use of fenoxycarb would
adversely affect endangered aquatic species because of
the low acute toxicity of fenoxycarb to this group and
the low use rates. The expected concentrations in 6
inches of water are less than 1/20 the fish LC 50 and
1/20 the daphnia LC 50 .
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It is unlikely that the u e of fenoxycarb would
affect avian 8pecies because of its low acute toxicity
and low use rate.
Tolerance Assessment :
There are no tolerances established for fenoxycarb.
‘4. Summary of Regulatory Position and Rationale
Fenoxycarb qualifies for a Section 3(c)(7)(C) registra-
tion based on submission of an almost complete data base, a
finding of no unreasonable adver8e effects, and a finding
that registration is in the public interest. The public
interest finding Is based on the chemical’s relativel 1 low
toxicity and its effectiveness (as attested to by USDA) in
fire ant control. The only study still to be submitted is
a soil photolysis study which i8 not typically required of a
surface applied formulation. The study is being required in
this instance because vegetation may shield the product from
sunlight. Because this data gap is a minor one, and because
the registrant could not have been expected to know of the
data requirement, the chemical is being conditionally
registered at this time.
The following Environmental Hazards text Is
required on manufacturing—use products because
of the hazards posed to aquatic invertebrates.
This pesticide is toxic to aquatic
invertebrates. Do not discharge effluent
containing this product into lakes, streams,.
ponds, estuarie8, oceans, or public water
unless this product Is specifically
identified and addressed in an NPDES permit.
Do not discharge effluent containing this
product into sewer 8ystems without
previously notifying the sewage treatment
plant authority. For guidance contact your
State Water Board or Regional Office of the
EPA.
o The following environmental statements are
required for end—u8e products.
This pesticide i8 toxic to aquatic
invertebrates. Drift and runoff from
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treated areas may be hazardous to aquatic
invertebrates in adjacent aquatic sites.
Do not apply directly to water. Do not
contaminate water by cleaning the equipment
or disposal of wastes.
Due to the use pattern and the low toxicological
characteristic to mammals, a reentry precautionary
statement is not required.
5. Summary of Major Data Gaps
° Environmental Pate Due Date
— Soil Photolysls 2/86
6. Contact Person at EPA : Timothy A. Gardner
Product Manager 17
Insecticide—Rodenticide Branch (TS-767C)
J 4 O 1 M StrI t SW.
Washington, DC 20’460
(703) 557—2690
DISCLAIMER: The information presented in this Chemical Information
Fact Sheet is for informational purposes only and may not be used
to fulfill data re4uirements for pesticide registration and
reregistration.
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