United State* Office of Pesticide* and Toxic Substances
Environmental Protection Office of Pesticide Programs (TS-766C)
Agency Washington. DC 20460
x°/EPA Pesticide
Fact Sheet
Name of Chemical:
Reason for Issuance:
Date Issued: Se^t- 30' 1984
Fact Sheet Number: 39
1. Description of chemical:
Generic Name: triphenyltin hydroxide
Common name: fentin hydroxide (BSI, ISO), triphenyltin hydrcccide (USA, S. Africa^
Trade name: Du-ter», Duter», Haitin, TPTR, TPTOH, Suzu H», Supertin, Tubotir*
EPA Shaughnessy Code: 083601
Chemical Abstracts Service (CAS) Nanber: 76-87-9
Year of Initial Registration: 1971
Pesticide Type: Fungicide
Chemical family: Organotin
O.S. and Foreign Producers: M &• T Chemicals (U.S.A.), Phil IDS -rxrohar (Netherlands.,
Nitto-Kasei Co. fJaoan''
2. Dse patterns and formulations;
Apolication sites: fo control earlv and late blioht on potatoes, leaf scot o-
suqar beets and peanuts, scab and several other diseases o-
oecans, leaf spot and alternaria blioht on carrots, anc tr
suppress spider mites on peanuts.
Types of fooDulations: Wettable powders and flowable suspensions
Types and Methods of Application: Aerial and ground sprays, application throuar
irrigation systems.
Application Rates: 1.5 to 12 ounces a.i./acre
Usual carriers: water, Surfactants, spreaders, or stickers should not t*
used because excessive phytotoxicity can result, 'tot tc
be used with oil sorays.
3. Science Findings;
Summary science statement:
TPTH is verv hiohlv toxic (Cateootv T) when it reaches the eves, or when
inhaled or absorbed throuoh the skin. Because the maior routes of Jurnar
-------
—2—
x sure are skin contact and inhalation, this hiah toxicity is cause for
cern. rprii produces birth defects in laboratory animals, can dar ae the
iTnuno1 ical system of exposed animals, produces lesions in the uteruses
of f y 1e rats arid has very hi subacute inhalation toxicity. It is not a
mutaqen.
th nica1 characteristics:
Thysical state: solid, fine pcMier
lor: ite to off-irthite
Q3or:
Va r pressure non-volatile
Melting mint: 11R—]20° C (technical)
F1 T bil1tv: 40(1° C
Octar ,1/i ter rtition coefficient: R.1270 arid 1370
Stability: decarc oees at abczit Rfl° to bis—tri ienyltin oxide
sPable at values of 5, 7, arid Q for >1(1 days
& lubiity: imter - B n n e - 4] a/I
ether - 28 a/I— Etharci — 10 g/l
1,2-Dich1oL thane - 74 g/l Acetone - 70 g/l
Methylene chloride — 171 g/l
th usua1 haii 1ing tharacterlst.tcs: Rrie ported (! data on explodability
or ,sion characteristics)
Tox i 1ogica1 characteristics:
Acute Effects:
Acute Oral U 0 — 165 ing/ (male rats), 156 /ki (f nale rats) (Category II)
Acute Dermal tD 5 - 127 im IIcxi (male rathits) (Category I)
flennal Irritation — Primary Skin Irritation (PS!) 2.R (Cateor rv UI)
Acute Inhalation Toxicity — 0.3 iz/J (Cateqory I)
Primary Eye Irritation — C nosive (Cat iorv 7)
Malor ites of Exposure: Dernal, inhalation
-------
—3—
thronic Effects:
C cogenicity - Caused pathological lesions on the uteruses of f nale rats
at l st dose tested (ZVP). Contr ersy as to whether this
is an crxx genic effect has not yet been resolved.
ratology - Caused hydrocephalus and h droneŘiroeis at < 1.25 nc,lcg
(1 st level tested). Other effects: abortions, decreased
body i 1 t qain, decreased % live fetuses, decreased fetal
weiaht, increased resorptions.
Plitagenicity - ) t a illitagen
Invi.u ot icity — Effects soleen iah t and I ?FC spleen cells and spleen
cell response to mitoc ens at 2.5 ng,lc i/dav (IVP). Decreased
leukocyte counts re observed at ncst dose levels, includir
wr. St y does not sh a ? served P fects Lecel (r& ).
Subacute Inhalation - Effects re noted at 0.0011 mg/liter (rflr), inclodino
a1 ecia, i’as 1 disd arge, red ears, ptosis,
pioerection, and epithelial hv rplasia of the skin.
The hist atho1o y report has not been caipletth the
effects at 1 r dose levels have not been evaluated.
ysiologice1 and -Bioth iica1 Behavioral tharacterist ice:
Pranalocation: I es not translocate
wircrmenta.1 tharacteristice:
beorbtion and 1eathin d aracteristice : Relatively fiwcbile in sandy
clay 1o , and silty clay loan soils.
Loss fr d iotodearadation and/or volatilization: W information is
available on photodegredation or volatilization. rii has l va r
Dreesure, so little volatilization is expected.
Resultant aver e persiatance: Ralf—life of 1 to 3 months in iandv and
silt 1o n soils, 126 days in flooded silt lomb.
Ba.lf—life in 1 ter: Stable to hydrolysis for 30 days at 21° C, loss of
16% at 32°C
-------
-4-
cologica1 tharacteristi :
Razards to Birds: Cannot be estimated with t i re data
Razards to Fish arid uatic Invertebrates: Any use pettern that ,uld
result in ccntaitinati of uatic systei thrcu h drift or rw off
ccxmld result in hi risk to p ulaticns of fish arid ac uatic invertebrates,
because of the very hiqh tc icity of yrii to uatic or aniar . MDTe data
persistance and thrcr ic effects are needed to c x lete the hazard
evaluaticxL
Potential Prob1ee with Fndari ered Species: Cannot be estimated withcut
data. uatic species u)d prestm bly be at hi risk if ex eed.
Tolerance Peasses nt:
List of -c arid tolerances: ( R 180.236)
(PW) (PW)
8eets, s ar, 1 ts 0.1W Carrots fl.1
Cattle, kidney C.09 Cattle, liver 0.05N
(bats, kidney 0.0 ats, iver 0.05N
Hoqs, kidney 0.0 Ro , liver fl.09q
RCLSSB, kidney 0.0w Horses, liver 0.05N
Peanuts 0.0 J Peanuts, hulls 0.4
Pecans 0.05 tatoes t1.05N
Sheep, kidney 0.0 N Sheep, liver 0.OSN
•‘N stands for Nealicdble 1 sidues .
List of food tact uses: Pecans, peanuts, potatoes, carrots
Pesults of tolerance assesgient: Ho AD! can be set at this tine
Prcbl )mc rm to have oociired fra!t use: PDtS file tains eiaht
entries, accordina to its index. cannot retrieve the data at this
time (Sept 1984).
-------
—5—
4. Sjiinarv of Regulatory Fositior and Rationale :
use C ia sification: Reclassified ( ‘ the Reaistration StaMard) as
a Restricted t e d nical because of t icity and teratcx enic effects.
Use, Fonnulaticri or Geogra ic Restrictions: Manufacturing use products
may only be fonn i1ated into end-use p *1ucts intended for use as a
fw icide on pecan trees, peanuts, carrots, tatoes, s ar beets,
and tobacco, or as anti—f ling petht, or spider mite suçreeaants
on peanuts.
Unique Label i rning atatenenta:
a. Hazards to B rens Stat nts
Labels of sanufacturing-use and foniiilated -use products ( JPs) iast
bear the stat nts:
9 1 - Fatal if inhaled. OL caive, causes i versible eye da aqe.
May be ha ui or fatal if eimll d or abeorbed thrc the skin.
DO r t aet in eyes, or a akin. DO r t breathe dust, va r, or sp ’
mist. it handling either products containing i vr or p ay-di1uted
mixtures, ar otective c]othth (long oants, boo sleeve shirt,
i r eable g1 res, hat, boots, and a sticide respirator lointlv
at oved q the Mining Th forcenent w Safety inistrat ion and the
t ticzia1 Thstitute for i ticmal Safety and Healthq) then handling
concentrated products, i ar a face shield. I sh thorcziqhly with soap
arid ter after handlirx* arid before eating or e
contariinat& clothing imah before rei e. Do r t enter treated
areas for at least 24 honra after treatnent.’
‘Ibe United States wi vental Protection Mency has determined that
tri ervyltin hydruiid u s birth defects in laboratory anujyals.
posure. to tri enyltin hydroxide during preanancy 1d be avoided.’
The iord isCI ’ (in red letters) arid a skull arid cos es mist a ear
in close ,. i iity to the w,rd ‘E 1 .
-------
-6-
b. Staterents of Practical Treathent
Labels of manufacturinq-uae and end-use pr ucts imist bear the stat nents:
‘ If a skin : 1 sh with plenty of ap and ter.’
‘ If irthal 3 : e victim to fresh air. If not breathing, qive artificial
respiration, preferably mouth-to-,iajth. C t n ic 1 attenticm.’
‘ If in eyes : Flush with plenty of 1 ter. Call a iysician.’
‘ If swallc .ed : Do riot induce vanitir . Drink a aii tly a large Quantity of
milk, egg thites, gelatin solution, or if these are not avaiIable
large auantitiee of imter. Call a J* y5ician or ie x ntrol C nter.’
C. vi ntal Razard Stateaent
The foll ,ir specific stat ts must ar on the labels of all
ruafactLzrinq use oducta
This pesticide is t ic to fish and wildlife. Do not died arqe into
lakes, strews, ponds, estuaries, c ans, or pi*ilic imters iziless this
pru ict is apecificmlly Identified eddreaeed In a zzit.
Do not diad iarqe eff1i nt containina this pr uct to cci r ayst
without previously notifying the aei e treathent plant authority. For
iidance ountact your State 1 ter bard or gicnal C f ice of the gPA.
All labels o s intended for outdoor use must bear thfs 8tat ient:
This pesticide is tc ic to fish ai wildlife. lb riot apily directly
to inter or wetlands. Drift or rw off fr â treated areas may be hazardous
to iuatic o anim!m in neicthborina are e. r or incori:*,rate spills.
lb not ccift inate ister 1q cleaninq of a aipaent or disp l of west s.’
-------
—7—
d. DispoGal Stat TentS
All labels of mnufacturina use or formulated end-use prCx uCtS (EUPs)
imist bear this state nt, lzKier the he inc ‘S’I X A? DIS AL’:
‘ r t oonta tinate water, food, or feed r stor e or disposal. Pesticide
wastes are aaitely hazardous. q er disposal of excess pesticide,
spray mixture, or rinsate is a violation of P eral law. If these wastes
nr t be disposed of t r use according to label instructions, cc* tact your
Stat’e Pesticide or wi L .IUental trol Agency, or the Hazardous Waste
representative at the nearest . Pegional Office for guidance.
The stat nents required r this star ard ‘ust apoear on the labels of a11
ItiPs ard JPs released for shipeient after Perth 30, 1984. After reciew
of data to be ih dtted mder this etar ard, the Aaenc ’ may im ose
*iditkmal label r u.ir nts.
mr ary of risk/benefit analysis: ? risk/benef it analysis per se has been done.
The cy has determine,3 that WTR..seets the risk criteria in 40 (PR ç162.ll(a),
orlssrily beceuse ‘wrti has pt’o&x ed terat çienic effects in latxratorv animals.
TYLII will be pl in the eciai iew process, during whid there will be
an analysis of its riskS benefits.
5. &mmary of n ior data ipe
! tes ič en malor data gape are due to be filled.
• 1 ta Pequested Die date
Description of mariifacturing process April 1, 1985*
Dis, aion of fo tion of ij lntentional inaredients April 1, l985
Preliminary analysis April 1, 1985*
rtificaticm of lImits April 1, 1985*
Analyticel sethods ard data for enfor nent of lImits April 1, 198 5*
Vipor pteaaure April 1, 19R5
Plant residues April 1, IQP5
1ma1 residues A ri1 1, 1985
-------
-8-
Data Reauested (c tinued)
tile Date
Storage stability data
Maqnit z3e of the residue for eath food use
Photc,degradation
Metabo1i n stodies in lab
P bility sttxlies
Disaipatia stiiliee in fieiii
Ac .rulatia et ies in rotaticnal
cu u1atiQ stirlies in fi
entry protecticn
90-day feedinq (rodent)
40-day fe 3im (na —rodent)
21-day der,i 1
90-day inhalatiai
thr ic toxicity
coaenicity
T ratogenicity
Reproducticm (2- r ratia )
a r 1 aberratia,
Other ger ,toxic effects
neral set& oli
Aviw dietaiy toxicity
Avian oducti
,lds ter fish aaite toxicity
Dansity, * lk density, or ecific gravity
c cidizir /reducing acti
Exploiabil ity
Corroaia
A rl1 1, 1985*
April 1, 1985
April 1, 19R5
? ber 1, 1986
April 1, 1985
) Tt r 1, 1986
? rber 1, 1486
April 1, 1985
) e tber 1, 1Q86
January 1, 1986
January 1, 1486
A ri1 1, 1985
April 1, 1985**
April 1, l985 *
April 1, 1985***
April 3, 19R5****
Se tenber 1, 1986
Sept t*r 1, 1986
Septanber 1, 1986
Pebruarv 1, 1986
April 1, 1985
April 1, 1986
April 1, 3485
April 1, 1985*
April 1, 1985*
April 1, 1985*
April 1, 1983*
*Product_specific data reauired for i nufacthrina use oroducts cx*ttainina TFIII.
**If the reaiatrant m ita to car uctIz*z n , stuftes, the de&3line is January 1, 1986.
***yf the reaistrânt xzimiita to ocnductir new stodies, the dealline is
v nber 1, 1988.
**W f the reaistrant e nits to ductir nsv stzxiies, the dea3line is
1 er 1, 3985.
-------
-4-
6. C taat person at EPA : Renry 3aco ’, U.S. viroxrenta1 Protection kiency,
TS—767-C, 401 14 Street i, shir tcn, DC 20460
(703) 557—1900
DISC AD ER: The info iat ion presented in this ni l Info ation Pact eet
is for infornatianal purpoees only ard i v r t be used to fulfill data
r uirdrents for pesticide registration aid rerecistration.
------- |