United Stnei Office of PattieidM and Toxic Subrtancei
Environmental Protection Office of Pertidde Programs (TS-766C)
Agency Washington. DC 20460
Pesticide
Fact Sheet
Name of Chemical: ALDRIN
Reason for Issuance: REGISTRATION STANDARD
Date Issued: DECEMBER, 1986
Fact Sheet Number: 108
1. DESCRIPTION OF CHEMICAL
Generic Name: 1,2,3,4,10,10-hexachloro-l,4,4a,5,8,Sahexahydro-
exo-1,4-endo-5,8-dimethanonaphtalene.
Common Name: Aldrin
Trade and Aldrine, HHDN, Aldrex®, Aldrex 30®, Aldrite®,
Other Aldrosol®, Altox, Bangald®, Drinox®, Octalene®,
Names: Rasayaldrin®, Seedrin® Liquid, Entoma 15949 and
Compound 118.
EPA Shaughnessy Code: 045101
Chemical Abstracts Service (CAS) Number: 309-00-2
Year of Initial Registration: 1949
Pesticide Type: Insecticide
Chemical Family: chlorinated cyclodiene
U.S. and Foreign Producers: Shell International Corp.
2. USE PATTERNS AND FORMULATIONS
Application Sites: soil surrounding wooden structures for
termite control
Types of Formulations: 2 and 4 Ib/gal emulsifiable concentrates
Types and Methods of Application: trenching, rodding, subslab
injection, low pressure spray
Application Rates: 0.25 to 0.5% emulsion
3. SCIENCE FINDINGS
Summary Science Statement
Aldrin is a chlorinated cyclodiene with high acute toxicity.
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The chemical has demonstrated adverse chronic effects in mice
(causing liver tumors). Aidrin may pose a significant health
risk of chronic liver effects to occupants of structures
treated with aidrin. The Agency is continuing to evaluate
the potential risk from the termiticide use of aldrin to
determine whether further regulatory action may be warranted.
Aidrin is extremely toxic to aquatic organisms and birds.
Aldrin is persistent and bioaccumulates. Aldrin may have
a potential for contaminating surface water; thus, a special
study is required to delineate this potential. Applicator
exposure studies are required to determine whether exposure
to applicators may be posing health risks. Special subacute
inhalatioon testing is required to evaluate the respiratory
hazards to humans in structures treated with aidrin. Data
available to the Agency show a pattern of misuse and misap-
plication of aidrin. The Agency is requiring restricted use
classification of all end—use products containing aldrin.
Application must be made either in the actual physical presence
of the Certified Applicator, or if the Certified Applicator
is not physically present at the site, each uncertified
applicator must have completed a State approved training
course and be registered in the State in which the uncertified
applicator is working.
Chemical Characteristics of the Technical Material
Physical State: Crystalline solid
Color: Tan to dark brown
Odor: Mild chemical odor
Molecular weight and formula: 364.93 — C 12 H 8 C1 6
Melting Point: 104 to 104.5 °C
Boiling Point: Decomposes at 1 atm.
Vapor Pressure: 6.6 x 10 mmHg at 25 °C
Solubility in various solvents: Very soluble in most organic
solvents; practically insoluble
in water
Stability: Stable with alkali and alkaline—oxidizing agents; not
stable with concentrated mineral acids; acid catalysts,
acid—oxidizing agents, phenols, active metals
Toxicology Characteristics
Acute Oral: Data gap
Acute Dermal: Data gap
Primary Dermal Irritation: Data gap
Primary Eye Irritation: Data gap
Skin Sensitization: not a sensitizer
Acute Inhalation: Data gap
Major routes of exposure: Inhalation exposure to occupants of
treated structures; dermal and
respiratory exposure to termiticide
applicators.
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Delayed neurotoxicity: does not cause delayed neurotoxic
effects.
Oncogenicity: This chemical is classified as a Group B2
(probable human oncogen). Rat oncogenicity
study is a data gap. There are three long—term
carcinogenesis bioassays of aidrin in mice which
were independently conducted by investigators
affiliated with the National Cancer Institute
and the Food and Drug Administration. These
studies were found to produce significant tumor
responses in three different strains of mice
(C 3 H, CF 1 , and B6C3F 1 ) in males and females
with a dose—related increase in the proportion
of tumors that were malignant.
Available data from seven existing carcinogeneSis
bioassays in rats are inadequate and inconclusive
and a well—designed study in rats is needed
to determine the carcinogenic potential of
aidrin in this species.
Chronic Feeding: Based on a rat chronic feeding study, a Lowest
Effect Level (LEL) of 0.025 mg/kg/day has beer
calculated.
Metabolism: In biological systems, aidrin is readily epoxidizec
to dieldrin.
Teratogenicity: Data gap
Reproduction: Data gap
Mutagenicity: Aidrin does not possess mutagenic activity in
bacteria. Further testing is required to
assess the inutagenic potential of aidrirt in
eukaryotes.
Physiological and Biochemical Characteristics
The precise mode of action in biological systems is not
known. In humans, signs of acute intoxication are primar-
ily related to the central nervous system (CNS), including
hyperexcitability, convulsions, depression and death.
Environmental Characteristics
Available data are insufficient to fully assess the environ-
mental fate of aldrin. Data gaps exist for all applicable
studies. However, available supplementary data indicate
general trends of aidrin behavior in the environment. Aidrin
degrades readily to dieldrin, which is persistent in the
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environment. Reports on leaching and field studies suggest
that aldrin/dieldrin would be unlikely to leach to underground
aquifers. However, additional data are necessary to assess
the potential for ground—water contamination as a result of
the termiticide use of aldrin.
Ecological Characteristics
Avian oral toxicity: 6.59 mg/kg in bobwhite quail; 52 mg/kg
in mallard ducks.
Avian dietary toxicity: 34 and 155 ppm in Japanese quail and
mallard duck, respectively.
Freshwater fish acute toxicity: 5 and 53 ppb in largemouth
bass and channel catfish,
respectively (warmwater species),
2.6 and 8.2 ppb in rainbow trout
and chinook salmon, respect-
ively (coldwater species).
Freshwater invertebrate toxicity: 18 ppb in a species of
seed shrimp; 32 ppb in
a species of water flea.
4. Required Unique Labeling and Regulatory Position Summary
EPA is currently evaluating the potential human health
risks of 1) non—oncogenic chronic liver effects, and 2) oncogenic
effects from exposure to aldrin. Following the completion of
Registration Standards on alternative chlorinated cyclodiene
termiticides (chlordane and heptachlor) EPA will determine whether
the risks posed by the termiticide use of aidrin warrant further
regulatory action.
O In order to meet the statutory standard for continued
registration, retail sale and use of all end—use products containing
Aidrin must be restricted to Certified Applicators or persons
under their direct supervision. For purposes of Aidrin use,
direct supervision by a Certified Applicator means 1) the actual
physical presence of a Certified Applicator at the application
site during application, or 2) if the Certified Applicator is
not physically present at the site, each uncertified applicator
must have completed a State approved training course and be
registered in the State in which the uncertified applicator is
working; the Certified Applicator must be available if and when
needed.
O In order to meet the statutory standard for continued
registration, Aldrin product labels must be revised to provide
specific Aldrin disposal procedures, and to provide fish and
wildlife toxicity warnings.
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O The Agency is requiring a special monitoring study to
evaluate whether and to what extent surface water contamination
may be resulting from the use of Aidrin as a termiticide.
o Special product—specific subacute inhalation testing is
required to evaluate the respiratory hazards to humans in structures
treated with termiticide products containing Aidrin.
O The Agency is requiring the submission of applicator
exposure data from dermal and respiratory routes of exposure.
O While data gaps are being filled, currently registered
manufacturing use products and end use products containing Aldrin
may be sold, distributed, formulated, and used, subject to the
terms and conditions specified in the Registration Standard for
Aldrin. Registrants must provide or agree to develop additional
data in order to maintain existing registrations.
5. TOLERANCE REASSESSMENT
No tolerance reassessment for Aidrin is necessary since
there are no food or feed uses.
6. SUMMARY OF MAJOR DATA GAPS
O Hydrolysis
o Photodegradation in Water
O Aerobic Soil Metabolism
o Anaerobic Soil Metabolism
O Leaching and Adsorption/Desorption
O Aerobic Aquatic Metabolism
O Soil Dissipation
O Reproductive Effects in Rats
O Rat Oncogenicity Study
o Mutagenicity Studies
O Teratology Studies
o Battery of Acute Toxicity Studies
O Special Surface Water Monitoring Studies
O Applicator Exposure Studies
Special Guinea Pig Inhalation Study
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All Product Chemistry Studies
7. CONTACT PERSON AT EPA
George LaRocca
Product Manager (15)
Insecticide—Rodenticide Branch
Registration Division (TS—767C)
Office of Pesticide Programs
Environmental Protection Agency
401 M Street, S.W.
Washington, D.C. 20460
Office location and telephone number:
Room 204, Crystal Mall #2
1921 Jefferson Davis Highway
Arlington, VA 22202
(703) 557—2400
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