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Du*onm«rn«l Protection Offiei of Porticitf* Program* (TC-766C)
A0*ncy WMMngton. DC 20460
vvEPA Pesticide
Fact Sheet
Name of Chemical: isomate-M
Reason for Issuance: New Biochemical Pesticide
Date Issued: M 3 I
Fact Sheet Number: 12g
1- Description of Biochemical Pesticide (Pheromone)
Chemical Names; 2-8-dodecen-l-yl-acetate
E-8-dodecen-l-yl-acetate
2-8-dodecen-l-ol
Common Name: Oriental Fruit Moth Pheromone
Trade Name: Isomate-M
EPA/OPP Chemical Code (Shaughnessy) Number(s):
2-8-Dodecen-l-yl actetate - 128906
E-8-Dodecen-l-yl acetate - 128907
2.9-Dodecen-l-ol - 128908
Chemical Abstracts Service (CAS) Number: 410C
Year of Initial Registration: 1986
Pesticide Type: Biochemical Pesticide
U.S. and Foreign Product(s): Biocontrol, Ltd. of Australia
2. Use Pattern and Formulation(s);
Application Site: Six-inch polyethylene tle-ons for fruit trees
in orchards (specifically peaches and nectarines).
Pests Controlled: Oriental Fruit Moth (GraphoHtha molesta).
3. Science Findings
Summary Science Statement:
The available information that has been reviewed suggests that Isomate-M
is potentially safer than many conventional pesticides currently used
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for control of the same pest. Due to the fact that this product is a
pheromone which will be used only in plastic dispensers, environmental
exposure is expected to be minimal.
Biochemical Pesticide Characteristics :
Isomate-M is a pheromone of the oriental fruit moth. Control of the
pest is obtained through mating disruption.
This pheromone is applied only In plastic dispensers which are twisted
around the branches of peach/nectarine trees in the orchard. Applica-
tion rate is four dispensers per tree In standard orchard spacing,
or 400 dIspensers per acre. This is equivalent to approximately 30 mg
of active Ingredient per hour, or 12.145 mg per acre per hour. lsomate-M
is species-specific; therefore, it does not affect other nontargeted or
beneficial species.
Data Requirements
1. Product Analysis :
Product identity and disclosure requirements have been satisfied.
2. Residue Chemistry Data :
Residue chemistry data are applicable only if Tier II or Tier III
toxicology data are required as specified by 40 CFR 158.165(e).
This was not the case with this product. Therefore, no residue
data are reouired In order to register Isomate-M.
3. Ecological Effects Data :
The applicable data requirements consist of the following:
a. Avian single-dose oral toxicity test for one species,
preferably bobwhite quail (Guideline No. 154-6);
b. F4sh acute bioassay for one species, preferably rainbow trout
(Guideline No. 154-8); and
c. Aquatic Invertebrate acute bioassay, preferably Daphnia
(Guideline Plo. 154-9).
These tests must be conducted with technical material, and the
protocols, including formulas for calculating maximum dose levels, for
conducting the studies can be found in Pesticide Assessment Guidelines,
Subdivision M, Biorational Pesticides, EPA—540/9-82—028, October 1982.
The registrant has agreed to submit these data. The Agency has
decided to issue a conditional registration contingent on the
submission of these data.
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Toxicology Data
The company submitted a battery of studies as required by 40 CFR
158.165(c).
These studies included the following data which were reviewed
and classified as follows:
1. Acute oral L0 50 , rat
ID5 = > 20 mL/kg (17.12 gfkg)
Toxicity Category: IV
Classification : Core Minimum Data
2. Acute dermal LD 50 , rat
LD 50 = > 2000 mg/kg
Toxicity Category: III
Classification : Core Minimum Data
3. Primary dernial irritation, rabbit
P.!. score = 0.96, a slightly
irritating agent
Classification : Core Minimum Data
4. Primary eye Irritation, rabbit
No corneal opacity or iritis.
Conjunctival redness in all eyes at
1 and 24 hours, which persisted in
three eyes to 48 hours.
Toxicity Category: III
Classification : Core Minimum Data
5. Acute inhalation toxicity, rat
At- 1 ,t 4 halation LC 50 = > 4.7 mg/L
Toxicity Category: III
Classification : Core Minimum Data
6. Ames Mutagenicity Assay
No mutagenic potential shown by this
assay.
Classification : Acceptable study
Sumary of Regulatory Position and Rationale :
Section 3(c)(7)(C) of FIFRA requires that a public interest finding
be made before a conditional registration can be Issued. The Agency has
concluded that this requirement has been satisfied.
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tsanate—M is a relatively 1c i—toxicity pesticide which is
encapsulated in a plastic tube. This product will be used as part of
an Integrated Pest Management system. This will result in the reduction
of the use of broad spectrum conventional pesticides of relatively higher
toxicity.
Furthermore, the development and use of these innovative methods of
pest control are deemed to be in the public interest, since they may
serve to alleviate the use of larger quantities and frequency of use
of the nore conventional pesticides.
Contact Person at EPA :
Arturo E. Castilj.o
Product Manager (17)
Registration Division (IS—767C)
Office of Pesticide Programs
Environmental Protection Agency
401 M Street SW.
Washington, D.C. 20460
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