GUIDANCE FOR THE
REREGISTRATION OP PESTICIDE PRODUCTS
(REGISTRATION STANDARD)
CONTAINING
AS THE ACTIVE INGREDIENT
ORYZALIN
Case number: GS-0186
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDE PROGRAMS
WASHINGTON, D.C. '20460
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TABLE OF CONTENTS
Pace
INTRODUCTION ...................... 1
PART I. REGULATORY ASSESSMENT ............. 3
A. Description of Chemical
B. Summary of Assessment
C. Agency Assessment
D. Regulatory Position and Rationale
PART II. REQUIREMENTS FOR REGISTRATION ......... 17
A. Criteria for Registration
B. Acceptable Ranges and Limits
C. Required Labeling
D. Submission of Generic Data
E. Instructions for Submission
APPENDICES
A - EPA Index to Pesticide Chemicals - Oryzalin . . M5
B - Labeling Requirements ............. 121
1. Submission of Revised Labeling
2. UO CFR 162.10 Labeling Requirements
3. Table of Labeling Requirements
U. Physical/Chemical Hazards
Labeling Statement
C - Container Disposal Instructions ........ 1U3
D - Farmworker Safety Label Requirements ..... IU5
E - FIFRA §3(c)(2)(B) Summary Sheet
(EPA Form 8580-!) ............. 15*»
F - Certification of Attempt to Enter Into
an Agreement with Other Registrants for
Development of Data (EPA Form 8580-6) ..... 156
G - Formulator ' 3 Exemption Statement ........ 158
BIBLIOGRAPHY ...................... 160
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INTRODUCTION
The Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA),
Section 3(g), directs EPA to reregister all pesticides as
expeditiously as possible.
To carry out this task, EPA has established the Registration
Standards program, which reviews all pesticide products contain-
ing active ingredients first registered before January 1, 1977.
Pesticides are reviewed in use clusters which have been ranked to
give earliest review to pesticides used on food and feed crops.
The Registration Standards program involves a thorough review of
the scientific data base underlying pesticide registrations and
an identification of essential but missing studies which may not
have been required when the product was initially registered or
studies that are now considered Insufficient. EPA's reassessment
results in the development of a regulatory position, contained
in a Registration Standard, on each pesticide and its uses. The
Agency may require the registrant to modify product labels to
provide additional precautionary statements, restrict the use of
the pesticide to certified applicators, provide reentry intervals,
modify uses or formulation types, specify certain packaging
limitations, or other requirements to assure that proper use of
the pesticide will not result in unreasonable adverse effects on
the environment.
The scientific review, which is not contained in the Registration
Standard, but is available from the National Technical Information
Service, concentrates on the technical grade of the active
ingredient and identifies missing generic data. However, during
the review of these data, the Agency is also looking for potential
hazards that may be associated with the end-use (formulated)
products that contain the active ingredient. If the Agency has
serious concerns, the end-use products will be addressed as part
of the Registration Standards program and regulatory actions, to
the extent necessary to protect the public, will be proposed.
This Registration Standard contains the results of the Agency's
review of all registered manufacturing-use products (MPs) contain-
ing oryzalin as the sole active ingredient. During this review,
the Agency evaluated all MPs and Section 3 and 2^(c] uses
registered for oryzalin.
Part I, Regulatory Assessment, of this Standard contains a
description of oryzalin and a summary of the Agency's assessment
of the chemical. This is followed by a more thorough discussion
of the data base and the resulting regulatory position.
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Part II, Requirements for Registration, of the Registration
Standard addresses the necessary requirements for maintaining
registrations of products containing oryzalin, along with the
instructions for submission of the data and information to the
Agency.
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PART I. REGULATORY ASSESSMENT
The Agency has conducted a thorough review of the scientific
data base on orzyalin. This Part of the Standard sets forth the
results of that review beginning with a description of the chemical
and its uses, followed by a discussion of the data base and the
resultant regulatory position. A summary of the Agency's review
and position precedes the discussion.
A. DESCRIPTION OF CHEMICAL
1. Description
Common Name
Chemical Name
Empirical Formula
Trade Names
Chemical Abstracts
Service (CAS) No.
OPP (Shaughnessy) No
2. Use Profile
Orzyalin
3,5-dinitro-N!|,NIt-dipropylsulfan-
11 amide
C12Hl8Ni,06S
Ryzelan, SURPLAN, EL-119
104201
Type of Pesticide
Pest Controlled
Registered Uses
Predominant Use
Method of Application
Mode of Activity
Formulations -
Technical
End Use
Preemergence Herbicide
Annual Grasses; Broadleaf Weeds
Croplands-. Noncroplands • Forestry
Soybeans (86.1 percent)
Broadcast: Banded Around- Aerial:
Irrigation Systems
Inhibition of root and shoot
growth of germinating weed
seedlings
95 percent active ingredient
Emulsiflable Concentrate;
Wettable Powder; Flowable
Liquid
3- History. Oryzalin was patented by Eli Lilly Company
(U.S. Patent No. 3,367,9^9) in 1969 and was first
registered for use in 1974. Technical oryzalin is being
produced in the United States by Elanco Products Company
of Indianapolis, Indiana, and at the present time, Elanco
is the sole registrant of products containing oryzalin.
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SUMMARY OF ASSESSMENT. The Agency has reviewed all data
submitted to support the registration of oryzalln. Based on
the review of these data, the Agency has reached the
following conclusions. See Section C of this Part for a
discussion of this review.
1. Oryzalin poses a limited oncogenic risk from dietary
exposure. The pesticide was classified B2, a probable
human carcinogen, based on the following:
(a) Oryzalin was associated with significantly
elevated incidences of thyroid gland tumors and
three different categories of skin tumors in male
and female rats. A sig-nificant positive trend for
liver adenomas also occurred in male rats but the
elevated incidence of this tumor type at the high
dose level was only of borderline statistical
significance .
(b) Structural analogs of oryzalln have been reported
to cause similar types of tumors in rats.
However, the Agency has some reservation in the
classification of oryzalin as a B2 oncogen, i.e., the
tumors occurred in only one species of rodent (negative
in the mouse), and mutagenicity studies were essentially
n eg a t i v e .
2. Applicator risk can be reduced to acceptable limits
through the use of protective clothing and gloves.
3. Oryzalln has significant benefits that are not outweighed
by the identified risks.
As a result of this review, the Agency has identified missing
data to evaluate the environmental and human risks associated
with the use of oryzalin. These data must be developed in
order to maintain registrations of products or register new
products containing oryzalin. The table in this section
summarizes the data gaps, in addition to product chemistry
information. Please note that this is only a summary and
more details can be obtained by referring to Table A,
Section D of Part II.
The Agency has also determined that label revisions must
be made In the following areas:
o Grazing Restrictions o Protective Clothing
o Rotational Crop Restrictions o Chemigation Instructions
o Use Patterns o Posting Requirement
o Environmental Hazards
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SUMMARY OF DATA GAPS - ORYZALIN
(Refer to Table A, Section D, Part II,
for details regarding specific requirements)
DATA REQUIREMENT
REMARKS
VJl
158.125 Residue Chemistry:
171-4 Nature of Residue (Metabolism)
158.135 Toxicology:
83-1 Chronic Toxicity (Non-rodent)
84-2 Mutagenicity Testing
Chronic toxicity study design must include
evaluation of thyroid gland chemistry and
pathology to more fully assess thyroid function
158.130 Environmental Pate:
Degradation Studies
162-1/3 Metabolism Studies
163-1/2 Mobility Studies
164-1/5 Dissipation Studies
165-1/5 Accumulation Studies
Ground Water Assessment
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Section D contains a discussion of the Agency's review which
resulted in these determinations and Section C of Part II
contains the required wording for the labeling revisions.
AGENCY ASSESSMENT. The Agency has conducted a thorough
review of the scientific data base for oryzalin. The
conclusions and requirements to be imposed as a result
of this review are summarized above. The following is a
discussion of the results of the review.
1. Tolerance Reassessment. Tolerances have been estab-
lished for residues of oryzalin on a wide range of
raw agricultural products listed in 40 CPR 180.304.
The toxicity data considered in support of these
tolerances include:
a. A two-year mouse feeding study with a no-observed-
effect level (NOEL) of 500 ppm (71.4 mg/kg/day)
and no oncogenic effects observed up to 3650
ppm (5^7.5 mg/kg/day);
b. A two-year rat chronic feeding study with a NOEL
of 300 ppm; positive oncogenic effects were noted;
c. A one year mouse chronic feeding study with a NOEL
of 500 ppm:
d. A three-month rat subchronic feeding study with a
NOEL of 1600 ppm (80 mg/kg/day);
e. A three-month mouse subchronic feeding study with
a NOEL of 3650 ppm (547-5 mg/kg/day);
f. A three-month dog subchronic feeding study with
a NOEL of 750 ppm (18.75 mg/kg/day);
g. A. three-generation rat reproduction study with a
NOEL of 250 ppm (12.5 mg/kg/ day);
h. Rat teratology studies with NOELs of 225 mg/kg/day
and 2250 ppm; and
i. Rabbit teratology studies with NOELs of 125 mg/kg/day
The dog was determined to be the most sensitive species
to oryzalin. Therefore, the provisional acceptable
daily intake (PADI) for humans was based on the 3-month
dog feeding study (see item f. above). The PADI in
humans was calculated to be 0.02 mg/kg/day, with a
NOEL of 750 ppm (18.75 mg/kg/day) and a safety factor
of 1000.
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Of concern in the three-month study is a decrease in
the hematocrit and hemoglobin values. This study
was limited and of short duration, therefore, the
Agency has determined that non-oncogenic effects
following long-term exposure in a species other than
the rodent have not been adequately defined. A
long-term study (at least one year's duration) in
the dog is being required.
The maximum permitted intake (MPI) for a 60 kg human
has been calculated to be 0.5625 mg/day. To date the
tolerances granted have accounted for 2.3^% of the
acceptable daily intake (ADI) with a theoretical
maximum residue contribution (TMRC) to the daily
diet of 0.0132 mg/day (for an average 1.5 kg daily
diet) .
Because the Agency considers oryzalin to be a rat
oncogen, all existing tolerances and any proposed
tolerance(s) have been or will be, by necessity,
considered on that basis. However, the potential
impact of each new use on the ADI is also essential
and provides an additional check on estimating the
safety or hazard of each request. Because the ADI
is currently a value which is based on non-oncogenic
effects, the long-term dog study is considered an
important data gap in the toxicology profile of
oryzalIn.
No tolerances have been established for residues of
oryzalin in meat, milk, eggs, or poultry because the
parent compound was thought to be the only residue
of concern, and it was not present at detectable
levels in feed. The Agency has requested additional
metabolism studies in ruminants, chickens and plants
in order to more fully define the terminal residue
and identify If there are any metabolites which may
be of concern.
Tolerances for meat, milk, eggs, and poultry may be
necessary if it is determined that residues are
found in animal feed. At present, available toxicity
data support the existing crop tolerances as they
have been established at or near the limit of
detection. The Agency is requiring the submission
of residue studies in crops, plants and animals to
verify that this is the case.
Pending receipt of the additional studies requested,
the Agency will evaluate new uses and new tolerances
on a case-by-case basis and, if the Incremental
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risks are not slgnficantly increased, will continue
to establish new tolerances. However, food additive
tolerances under sec. 409 of the Federal Pood, Drug
and Cosmetic Act will not be established.
2. Preliminary Risk and Benefit Analysis
a. Risks?. To assess the risks associated with oryzalin,
the Agency reviewed the existing data base. This
included the review of studies conducted for oncogeni-
city, mutageniclty, teratogenicity and metabolism.
Based on these studies, dietary risk and applicator
exposure and risk have been calculated. The following
is a discussion of the results of the risk assessment.
(1) Oncogenicity Studies
Rat Study. Results in the Fischer 3^ rat
study showed that oryzalin, when administered
in the diet, was associated with significantly
elevated incidences of:
(a) Thyroid gland follicular cell adenomas and
carcinomas (combined) in high dose males
and females (primarily adenomas):
(b) Three different groups of skin tumors--fibromas
and fibrosarcomas (combined) in mid- and
high-dose males); papillomas, keratoacanthomas
and squamous cell carcinomas (combined) in
high dose males and females; and basal cell
adenomas and skin adnexal tumors (combined)
in mid- and high-dose males and females; and
(c) Mammary gland adenomas, fibroadenomas and adeno-
carcinomas (combined) in low-, mid-, and high-
dose females (primarily fibroadenomas). Tn
addition, a significant positive trend for
liver adenomas was observed but the elevated
incidence of this tumor type in high-dose
males was only of borderline statistical
significance.
Most of the tumors (except for liver adenomas)
occurred at incidences higher than historical
control incidences for the same respective
tumor type in F344 rats. (Recent NTP data: See
Handbook of Carcinogen Testing, H. A. Milrnan and
E. K. Weisberger, eds. pg. 282-325, In Press:
Toxicol. Pathol. 12:126, 1984).
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The elevated incidence of thyroid tumors observed
in high dose male and female rats was accompanied
by focal follicular hyperplasia of the thyroid
gland in males (control, 2/59; low dose 2/59; mid-
dose, U/57; high dose, 15/56) and females (control,
0/55; low dose, 1/59; mid dose, 5/57; high dose,
1^/55). Hyperplastic changes are a strong indicator
of an oncogenic effect.
In the chronic rat bioassay, the following were
observed at the three test levels:
(a) The highest dose tested (2700 ppm in the
diet) appeared to exceed a "maximum tolerated
dose" (MTD) level. The Agency noted that
some of the tumors that occurred in rats at
the 2700 ppm dose which exceeded the MTD
(i.e., tumors of the thyroid gland, skin,
and mammary gland) also occurred at doses
that did not exceed the MTD level (i.e.,
skin and mammary gland tumors at 900 ppm,
and mammary gland tumors at 300 ppm). The
effects seen at this dose included:
o Reduced survival (p < 0.05) in males and
females ;
o Weight loss (p < 0.05) in males and females
at the end of the studies;
o Depressed red blood cell, hemoglobin and
hematocrit levels in males and females;
o Increased SGPT and BUN levels in females
and increased creatinine levels in
females; and
o Elevated organ weights in males (liver,
kidney, thyroid gland, and heart) and
females (adrenal gland) .
(b) The mid-dose level (900 ppm) in rats did not
exceed the MTD. The only effects seen at this
dose were depressed red blood cell, hemoglobin
and hematocrit levels in females, and elevated
organ weights In males (liver and kidney)
and females (kidney).
(c) The lowest dose tested (300 ppm) resulted in
no observed adverse effects.
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There is presumptive evidence that the thyroid
gland tumors produced by oryzalin in male and
female rats were due to an anti-thyroid effect
of the compound. Although no biochemical tests
were performed to evaluate an effect of oryzalin
on thyroid function in the data available for
review, several morphological changes were
observed in the thyroid gland in the chronic
rat bioassays in addition to the tumors. These
included:
(a) Increased thyroid gland weights in high-dose
(2700 ppm) males.
(b) A dose-related increase in cystic follicles of
the thyroid in males (controls, 3/59; low-dose,
5/59; mid-dose, 12/57; high-dose, 19/56) and
females (controls, 2/55; low-dose,8/59; mid-dose,
13/57; high-dose, 15/55); and
(c) Focal follicular hyperplasia particularly at
the high-dose level, in males and females.
Mouse Study. Oryzalin was not oncogenic when
administered in the diet to B6C3P1 mice.
In the chronic mouse bioassays, th* highest dose
tested in males (3650 ppm in the diet) did not
exceed a MTD. The only effect seen at this dose in
males was a reduction in body weight gain (approximately
-5%) at the end of the study. In female mice, the
3650 ppm dose did appear to exceed a MTD. This dose
in females did not affect mortality but did produce
reductions in body weight gain at 12 months (-12%), 18
months (-15%), and 21 months (-19%) after the start of
the studies. In addition, reductions in blood glucose
levels and uterus weights were also noted.
Other Data. Information is available to suggest a
structural relationship between oryzalin and other
substances that have been demonstrated to be oncogenic
in rodents. Oryzalin is a para-substituted aniline
derivative and also a sulfonamide compound. The Agency
considered data indicating that dietary administration
of another para-substituted aniline derivative,
2, 4-diamlnoanisole, to rats Increased the incidences
of malignant tumors of the thyroid gland and the skin
in both sexes.. (NCI Technical Report No. 8*i, 1978).
In addition, data on two sulfonamides, sulfamethoxazole
and sulphisoxazole, were considered. Orally administered
sulfamethoxazole produced thyroid gland hyperplasia and
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neoplasia (nodules antl adenomas) in rats (IARC 2U: 285,
1980) whereas sulphisoxazole was negative for oncogeni-
city in rats and mice (IARC £4:275, 1980). Both of
these studies appeared to be adequately performed.
Furthermore, anti-thyroid effects have previously
been reported for para-substituted aniline derivatives
(of which the sulfonamides make up the greatest
number) in rats, mice, and dogs (Endocrinology 32;18S,
1943; Goodman and Oilman, 2nd ed., pg. 1301, 1970)
and "even in humans (Br. Med. J. 281:646, 1980;
Goodman and Gilman, 5th ed., pg. iTTl, 1975). On
the basis of this information the Agency considered
that oryzalin might act to cause thyroid tumors by
inhibiting the formation of thyroxin, resulting in
positive feedback stimulation of the pituitary gland
to release thyroid stimulating hormone (TSH) ,
thereby causing thyroid gland hypertrophy (goiter)
and the ensuing hyperplasia and tumor formation.
Along this line, the study design for the chronic
(1-year) toxlcity study in dogs being required to
fulfill EPA's requirements must include evaluation
of thyroid gland chemistry and pathology to more
fully assess thyroid function. studies appeared
to be adequately performed.
(2) Mutagenic Studies. No mutagenic effect of oryzalin was
detected in several tests to assess gene mutations and
chromosomal aberrations. The compound did exert a
positive mutagenic effect in one test (sister chromatid
exchange in Chinese hamster bone marrow cells) to assess
primary DMA damage/repair, but only when the Intra-
peritoneal route of administration was employed; no
positive effect was observed when the oral route of
administration was employed. The compound was also not
mutagenic in another ±n vitro test for primary DNA
damage/repair. The Agency is requiring that an _in
vitro cell transformation test be performed by the
registrant using oryzalin (other compounds demonstrated
to evoke thyroid gland tumors are positive in this
test) .
(3) Teratogenlc and Reproductive Effects Studies. In 1979,
investigations were undertaken by the Occupational
Safety and Health Administration and the National Institute
for Occupational Safety and Health concerning an allegation
by the International Chemical Workers' Union (ICWU) that
oryzalin may have caused production workers to father
children with heart defects. No link to the production of
oryzalin could be found in any of the investigations. In
this regard, the Agency evaluated several teratology and
reproduction studies in rats and rabbits. In a 3-generatlon
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rat reproduction study and two separate rat teratology
studies, there were no teratogenic effects on pup develop-
ment [NOEL 225 mg/kg/day (HOT)]. Furthermore, in the
two rabbit teratology studies there were, similarly, no
teratogenic effects to the fetuses. The repeat rabbit
study involved a detailed examination of the fetal
heart to determine if there was any substantial animal
evidence for the claims made by the ICWU. None was
found. The rabbit teratogenic NOEL is 125 mg/kg/day.
(4) Metabolism Studies. Adequate metabolism data for oryzalin
have not been obtained in animals. Several metabolites
have been identified in In vitro studies, but no toxicology
information is available for these and their relationship
to metabolites that might be formed in vivo has not been
demonstrated.
(5) Risk Assessment. The Agency has reviewed oncogeniolty
studies for oryzalin, and concludes that these data provide
sufficient evidence of oncogenicity for the chemical in
male and female rats. According to EPA Proposed Guidelines
for Carcinogen Risk Assessment (November 23, 1984, i»9 PR
4629*0 , oryzalin has been classified as a Category B2 oncogen,
that'is, a probable human oncogen.
The B2 classification is based upon several factors. One
is that oryzalin causes tumors at multiple organ sites in
the rat. A second factor is that the thyroid gland tumors
and two of the three groups of skin tumors occurred in both
sexes of the rat and, furthermore, the thyroid tumors were
associated with hyperplastlc changes of the thyroid gland.
Finally, other compounds that are both oncogenic and
structurally similar to oryzalin produce thyroid gland and
skin tumors in rats.
The Agency is aware that other aspects of the toxicology
data profile on oryzalin are less supportive of the B2
classification of carcinogenicity. For example, the
compound was not mutagenic in numerous genotoxicity tests,
and it was not oncogenic in the mouse. In addition, one
group of skin tumors (fibromas and fibrosarcomas) and the
mammary gland tumors occurred only in single sexes of the
rat. Finally, although the combined incidences of basal
cell adenomas and adnexal tumors of the skin were elevated
in both sexes of rats, it is difficult to ascribe the
observed combined increases to a change in any individual
basal cell or adnexal tumor type.
(6) Dietary Risk. The oncogenic evidence is discussed above.
The dietary risk associated with oryzalin is 10~5-10~6
(Class B2 carcinogen) using a TMRC of 0.0132 mg/day and a
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Q* of 3*10~2 (mg/kg/day)"! . Dietary exposure to oryzalin
was calculated based on assumptions that 100% of crops are
treated, and that exposed individuals consume only crops
containing residues at the tolerance level. In addition,
established tolerances have been based on no detectable
residue levels or levels at the sensitivity of the analytical
method (0.01 ppra).
Dietary exposure to oryzalin per se? appears to be minimal,
and EPA expects that, because of the assumptions made,
actual exposure is less than the calculated exposure.
Additional uses of oryzalin will be considered on a
case-by-case basis giving particular concern for detectable
levels of oryzalin per se, which may be present, as
well as clarification of the terminal residue in terms
of measurable metabolites.
(7) Applicator Exposure and Risk. The toxicology data strongly
indicate no toxic effects associated with dermal contact and
inhalation exposure to oryzalin. However, the Agency is
concerned about applicator exposure and risk because of the
oncogenic response in the rat study. Exposure, as discussed
below, has been estimated using the toxicology data which
indicate:
(a) Acute toxicity by the dermal route is low (>2 g/kg).
Oryzalin is not a dermal sensitizer; 2 separate
subchronic dermal studies using Surflan 75W and
Surflan UAS demonstrated no adverse effects to rabbits
when applied to intact or abraded skin at concentrations
of >4 .&% for 6 hrs . per day.
(b) Dermal absorption is poor. A percutaneous absorption
study using monkeys demonstrated a derma] absorption rate
of @ 1.6% of the applied dose. Moreover, the rate of
excretion is high compared to the rate of absorption.
(c) Compound-related effects associated with worker or
applicator situations have not been identified in
the epidemiology data.
Evaluation of mixer/loader/applicator exposure via the
dermal and inhalation routes have been estimated using
surrogate data for ground application of oryzalin in
almond orchards at 4 Ibs. a.1./acre and for both private
and commercial applicators to soybeans at 1 Ib. a.i./acre.
For almond orchards and private soybean applicators,
oryzalin is assumed to be used one day a year. Commercial
soybean applicators are assumed to apply oryzalin 15
days a year. Applicators were assumed to weigh 70 kg
and to work 35 years out of a 70-year lifetime.
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For use in almond orchards by workers in normal work
clothes, excluding gloves, dermal exposure is 7 mg/year
(incorporating the dermal absorption factor of 1.6$)
and inhalation exposure is 1 mg/year. This gives a
lifetime average daily dose (LADD) of 2xlO~i| mg/kg
day. For private soybean applicators, clothed as above,
corrected dermal absorption is 5 mg/year and inhalation
exposure is 1 mg/year with an LADD of 1x10"^ mg/kg/day.
For commercial applicators, clothed as above, the corrected
dermal absorption is 106 mg/year and the inhalation
exposure is 21 mg/year with.an LADD of 2xlO~3 mg/kg/day.
Using Q* = 3x10-2 (mg/kg/day)-1 (Class B2 carcinogen), the
upper 95% confidence limits on risks are
almonds
soybeans
soybeans
(pr ivate)
(commercial)
10-5 - 1Q-6
10-5 - 10-6
It is estimated that exposure to mixers/loaders/applicators
could be reduced by as much as 90% by use of impermeable
gloves and other protective clothing. Using these
protective measures, the upper 95% confidence limits on
risks as a Class B2 carcinogen are:
almonds
soybeans
soybeans
(private)
(commerc ial)
10-6 _ iQ-7
ID'6 - 10-7
10-5 - 10-6
b. Benefits. An assessment of the benefits of oryzalln was
made based on the use patterns of the chemical and the
alternatives available. The following is a result of that
assessment.
Oryzalin controls a wide spectrum of annual grasses and
broadleaf weeds (46 different weeds) in 32 fruits, nuts,
vineyards, forestry, noncrop areas, and certain agricultural
crops.
Oryzalln, unlike other dinitroaniline herbicides, can be
applied preemergence and can remain on the soil surface
for as long as 3 weeks before rainfall moves it into the
weeds germinating zones, whereas other herbicides require
rainfall within 7-10 days for activation or need to be
soil incorporated.
Oryzalin fits well into a no-till weed control situation
in soybeans, because it affords the grower flexible
timing and can be applied either in the fall, early
spring or over-the-top which reduces the need for
13A
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"burndown" herbicides. It can also be applied aerially,
by ground equipment, with liquid fertilizers, over-the-top
in tank mixes, or through chemigation systems. Oryzalin
is also widely tank mixed with various herbicides in
several crops to provide a wider weed control spectrum
and provides a low risk of carryover or subsequent
damage to the next crop.
Oryzalin is the only preemergence herbicide that can be
applied over-the-top of standing wheat or barley to
control spring germinating annual weeds. This use
helps make relay intercropping (planting soybeans in
standing wheat or barley before harvest) a more viable
cropping option.
In fruit, nut and vineyard crops, oryzalin gives the
growers the flexibility they need to control weeds from
2-12 months without phytotoxicity depending upon the
application rate selected. In ornamentals, the growers
can also vary their length of weed control from 2-8
months depending upon the application rate selected.
D. REGULATORY POSITION AND RATIONALE. Based on review and
evaluation of all available data and other relevant
information on oryzalin, the Agency has made the following
determinations:
1. If any of the risk criteria listed in Section I62.11(a)
of Title 40 of the U.S. Code of Federal Regulations
have been met or exceeded, a special review of the
chemical is conducted. Although oryzalin has met
one of the criteria, that of an oncogen in the rat,
with potential for oncogencity in humans, it is not
being placed into the special review process at this
t ime.
Rationale: After considering both dietary and applicator
exposure to oryzalin, the Agency has concluded that
the risks posed by oryzalin are minimal and hence
initiation of a special review is not necessary at
this time. The Agency has also reviewed the benefits
of oryzalin and has concluded that its benefits
outweigh its risks.
2. Registrants must place protective clothing statements
on the labels of manufacturing-use and end-use products
containing oryzalin. The specific language of these
statements is provided in Part II.
Rationale: Because of potential oncogenic risk from
oryzalin, the Agency is requiring protective clothing
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statements on labels for oryzalln products. Applicator
exposure and risks are discussed beginning on page 13.
These risks can be reduced to an acceptable level by
requiring persons who may come in contact with the
chemical to wear protective clothing.
3. The Agency has concluded that no change in present
tolerances is indicated at this time. New tolerances
will be evaluated on a case-by-case basis and new
tolerances established if the incremental risks are
not significantly increased. The Agency will require
additional residue and metabolism studies on soybeans,
potatoes, ruminants and chickens , in order to determine
the nature of the residue in plants and animals.
Rationale: Current tolerances are expressed in terms
of parent compound only: however, the Agency has
determined that the metabolism In plants and animals
is not adequately defined. Most tolerances for
oryzalin have been established at or near the limit
of determination of the analytical method sensitivity.
Available information indicates a need to further
clarify the composition of the terminal residue of
oryzalin in plants and animals.
4. The Agency is not requiring a reentry interval for
currently registered uses of oryzalin.
Rationale: The acute toxicity for oryzalin is low
(Category III). Additionally, exposure and the
resultant risks to field workers are expected to be
much lower than to applicators handling the chemical.
Therefore, no reentry Interval is required.
5. The Agency is requiring grazing restrictions for the
labels of all end-use products.
Rationale: There are currently no tolerances established
for residues of oryzalin in animals or animal byproducts.
6. The Agency is requiring crop rotation restrictions on
the labels of all end-use products.
Rationale: The root crop precaution is necessary due
to the longevity of this type of product in soil and
the lack of adequate residue data on such rotational
crops. It is the policy of the Agency to impose
restrictions on planting rotational crops when data
are insufficient to allow an assessment of the impact
of planting subsequent crops. This serves to protect
the public from impermissable residues In food and feed
15
-------
and to protect subsequent planted crops from adverse
effects due to persistent residues.
7. The Agency is imposing label requirements for end-use
products intended for use with center pivot irrigation
systems (chemigation). See Section C of Part II for
the specific language.
Rationale: Because of the oncogenic risk associated
with the exposure of oryzalln, the Agency is requiring
that labels of end-use products contain precautionary
statements to reduce the chance of Incidental exposure
to field workers.
8. While the data gaps are being .filled, currently registered
manufacturing-use products (MPs) and end-use products
(EPs) containing oryzalin as the sole active ingredient
may be sold, distributed, formulated and used in the
United States, subject to the terms and conditions specified
in this Standard. Registrants must provide or agree to
develop additional data, as specified in Table A of
Section D, Part II, in order to maintain existing regis-
trations .
The Agency will issue registrations for substantially
similar products. However new uses will be issued
only on a case-by-case basis after considering the effects
on the theoretical maximum residue concentration (TMRC)
and the maximum permitted intake (MPI), and the oncogenic
risks.
Rationale: Section 6 of FIFRA authorizes the Administrator
to cancel a pesticide registration if he determines that
the pesticide will cause unreasonable adverse effects on
the environment. Based on available data, the Administrator
has not made such a determination as to oryzalin. The
Administrator has authority under FIFRA sections 3(c)(2)(B)
and (3)(c)(7) to require registrants and applicants for
registration to provide data needed to support new or
continuing registrations.
Issuance of this Standard provides a mechanism for identify-
ing data needs. These data will be reviewed and evaluated
and the Agency will determine if the data will affect the
registration of oryzalin.
16
-------
PART II. REQUIREMENTS FOR REGISTRATION
This Part of the Registration Standard discusses what data and
information are required to maintain existing registrations or
register new products containing oryzalin. It also contains the
instructions for submitting the necessary data and information
to the Agency.
A. CRITERIA FOR REGISTRATION UNDER THIS STANDARD. To be
covered by this Standard, MPs must contain oryzalin as
the sole active ingredient, bear required labeling and
conform to the product composition, acute toxicity limits
and use pattern requirements listed in Section B.
The applicant for registration or reregistration of
products subject to this Standard must comply with all
terms and conditions described in it. This includes
making a commitment to fill data gaps on a schedule
specified by the Agency. Applicants for registration
under this Standard must follow the instructions contained
herein and complete and submit the appropriate forms
within the time specified.
B. ACCEPTABLE RANGES AND LIMITS
1. Product Composition Standard. Technical grade products
must contain at least 95-0 percent oryzalin as the sole
active ingredient. Each MP formulation proposed for
registration must be fully described with appropriate
certification of limits. In addition, the active
ingredient must be substantially similar to that in
currently registered technical products. Any MPs not
meeting these requirements will be considered a new
product and will not be registered under this Standard.
2. Acute Toxicity Limits. The Agency will consider
registration of technical grade MPs containing oryzalin
when the appropriate acute toxicity categories are no
higher than Category III. The labeling of any registered
products must bear the appropriate precautionary statements
3. Use Patterns. To be registered under this Standard,
MPs containing oryzalin must be labeled for formulation
into end-use products that are to be used for control
of germinating annual grasses and broadleaf weeds in fruit,
nuts, vineyards (nonbearlng and bearing), soybeans, cotton
(Texas only), peas (English or green), tobacco (air- and
flue-cured), potatoes (white), small grains (wheat and
17
-------
barley), forestry and Christmas tree plantations,
established ornamentals and noncropland (rights-of-way)
areas. Appendix A, EPA Index to Pesticide Chemicals -
Oryzalin, lists all registered uses, as well as approved
maximum application rates and frequencies of application.
REQUIRED LABELING. The required label statements must
appear on the labels of all products in channels of
trade within two years of issuance of this Standard.
After review of data to be submitted under this Standard,
the Agency may impose additional label requirements.
1. All Products. All products must bear appropriate labeling
as specified in 40 CFR 162.10. Specific information
regarding label requirements is included in Appendix B.
Oryzalin is not designated as an acute or toxic
hazardous waste under the Resource Conservation and
Recovery Act (RCRA). The label must bear the following
pesticide disposal statement:
"Wastes resulting from the use of this product
may be disposed of on site or at an approved
waste disposal facility"
The labels of all products must bear the appropriate
container disposal statement (see Appendix C).
2. Manufacturing Use Products. Labels of all MPs must
bear the statements:
"For formulation into end-use herbicide products
intended only for use on fruit, nuts, vineyards
(bearing and nonbearing) , soybeans, cotton (Texas
only), peas (English and green), Tobacco (air- and
flue-cured), potatoes (white), small grains (wheat
and barley), forestry and Christmas tree plantations,
established ornamentals and noncropland areas."
"Do not discharge effluent containing this product
into lakes, streams, ponds, estuaries, oceans, or
public waters unless this product is specifically
identified and addressed in an NPDES permit. Do
not discharge effluent containing this product to
sewer systems without previously notifying the
sewage treatment plant authority. For guidance
contact your State Water Board or Regional Office
of the EPA."
18
-------
"Protective clothing (coveralls, a long-sleeved
shirt, shoes and impermeable gloves) must be worn
when handling this chemical."
3 . End-Use Products
a. Labels of all
must bear the
formulated end-use products (EPs)
following statements:
"Do not graze or Teed forage
or orchards to livestock."
from treated fields
"Do not plant root crops for twelve months
following treatment."
"Mixer/loader/applicators must wear protective
clothing, consisting of coveralls, a long-sleeved
shirt, shoes, and impermeable gloves when handling
this product."
The labels of non-granular EPs intended for outdoor
use must bear the following statement:
"Do not apply directly
not contaminate water
or disposal of wastes
to
by
it
water or
cleaning
wetlands. Do
of equipment
The labels of all EPs applied by center pivot
irrigation systems must bear the following posting
requirements statement and the appropriate chemigation
instruc tions .
Posting Requirements
"Posting Requirements: Areas being treated
with pesticides applied through irrigation
systems must be posted at the usual entrances
to the area, at bulletin boards where workers
assemble and where the treated area lies
adjacent to roads, residential areas, or
any other areas such as schools, parks, or
other public facilities. Posted signs must
be legible from 25 feet away and be printed
in English and any other appropriate language
such as Spanish. Signs must be posted
prior to application, but may remain in place
indefinitely. The sign must indicate the
following:
19
-------
NOTICE
Pesticides are applied in irrigation
water in this field. Do not enter this
field when the irrigation system is
operating. Do not drink, bathe in or play
in water or in furrows, puddles, ponds,
canals or ditches associated with this
irrigation system."
Chemigation Instructions
(1) Apply only through properly maintained irrigation
systems having continuously moving laterals and
providing uniform distribution of water. Where
a system does not provide uniform water distri-
bution such as at the extreme .ends of the
lateral, around supports, where treated discharge
water is released from water-powered motors,
or where extreme changes in elevation occur,
unacceptable weed control or crop injury may
occur.
(2) Apply the product only through irrigation systems
containing anti-siphon and check valves, to
prevent water source contamination and overflow
and siphoning of slurry tank, and interlocking
controls between the metering device and the water
pump, to insure simultaneous shut-off.
(3) Inject the product with a positive displacement
pump into the main line ahead of a right angle
turn to insure adequate mixing.
(4) Application of more than label recommended
quantities of irrigation water per acre may
result in decreased product performance by
removing the pesticide from the zone of
effectiveness.
(5) Do not apply when wind speed favors drift, when
connections or fittings leak, when nozzles do
not provide uniform distribution or when lines
containing the product should be dismantled and
drained. Use of low trajectory angle sprinkler
or drop nozzles will decrease the likelihood
of drift .
(6) Greater accuracy in pesticide calibration and
distribution will be achieved by injecting a
larger volume of more dilute slurry per hour.
20
-------
(7) Constant agitation should be maintained in the
slurry tank during the entire period of pesticide
application.
d. The labels of all products with outdoor agricultural
uses and which are applied to crops utilizing hand
labor tasks must hear general precautionary language
about farmworker safety. See Appendix D for the
required language.
D. SUBMISSION OF GENERIC DATA. Generic data pertain to the
properties or effects of a particular ingredient, and thus are
relevant to an evaluation of the risks of all products contain-
ing that ingredient, regardless of the product's unique
composition or specific use. EPA has the authority under
FIFRA sec. 3(c)(2)(B) to require registrants to submit data
that will answer the Agency's questions regarding the hazard
that may result from the intended use of a pesticide.
Although sec. 3(c)(2)(B) provides that all registrants are
responsible for these data, the Agency generally imposes
generic data requirements only on the registrants of the
manufacturing-use products (basic suppliers of the
active ingredient) and other producers who do not qualify
for the formulator's exemption. The formulator's exemption
applies to a registrant of a product if the source of its
active ingredient(s): (1) is a registered product, and
(2) is purchased from a source which does not have ownership
in common with the registrant's firm.
A producer who currently does not qualify for the formulator's
exemption may qualify by changing its source of supply to
a registered source, provided the source does not share owner-
ship in common with the registrant's firm. A registrant may
do so by submitting a new Confidential Statement of Formula,
EPA Form 8S70-4 , identifying the registered source of the
active ingredient, to the Product Manager listed in Section E
of this Part within 90 days of receipt of the Registration
Standard. The chart on the following page shows what is
generally required of those who do and do not qualify for the
formulator's exemption in the Registration Standards program.
Registrants are reminded that FIFRA sec. 6(a)(2) requires that
factual information raising concerns of possible unreasonable
adverse effects of a pesticide must be promptly submitted. If
Interim results of studies In progress show possible adverse
effects, the Agency is to be notified of those interim results.
This portion of the Registration Standard is issued under the
authority of FIFRA sec. 3(c)(2)(B). Table A, following this
section, lists the data required for maintaining the regis-
tration of each product.
21
-------
PRODUCTS SUBJECT TO THE
REGISTRATION STANDARD
ACTION(S) REQUIRED TO
MAINTAIN REGISTRATION
I. Products That Do Not Qualify
Fbr The Ponnulator's Exemption
A. Single Active Ingredient
Products*
These products must be reregis-
tered. To obtain reregistration,
labeling, packaging and data
requirements must be satisfied
in accordance with the Regis-
tration Standard.
I
B. Multiple Active Ingredient
Products
These products will not be
reregistered at this time.
However, generic data required
to continue the registration of
the active ingredient under
review, as described in the
Registration Standard, will be
required and some labeling
precautions may also be
required.
II. Products That Do Qualify Fbr
The Formulator's Exemption
Only when additional restric-
tions or labeling are needed to
protect humans or the environ-
ment will these products be
subject to the Registration
Standard requirements. Affected
products will be dealt with in a
variety of ways, Including but
not limited to the Label
Improvement Program and special
intent to cancel notices.
* End-use products of registrants who also produce a manufacturing
use product will not be required to be reregistered provided that
registrant fulfills the requirements specified in the Registration
Standard for manufacturing-use product(s) . Such end-use products
will be subject to the labeling changes required for products In "II"
above. If there are no manufacturing-use products registered by any
company, end-use products will be required to be reregistered.
NOTE: If all registrants in "I" above fail to meet the requirements in
I-A and B above, the registrants in "II" lose their right to qualify
for the formulator's exemption and become subject to the requirements
in I-A and B.
22
-------
EPA has determined that additional generic data described in
Table A must be submitted to EPA for evaluation in order to
maintain in effect the product registration(s). As required
by PIFRA sec. 3(c)(2)(B), registrants are required to take
appropriate steps to comply with this Standard.
EPA may suspend the registration of products unless, within the
specified time, the registrant informs EPA how it will satisfy
the requirements of this Standard. Any such suspension will
remain in effect until the registrant has complied with the
terms of this Standard.
1. What Generic Data Must be Submitted. Registrants may
determine which generic data must be submitted by consulting
Table A. That table lists the generic data needed to evaluate
the continued registrabHity of all products, and the dates
by which the data must be submitted. The required studies
must be conducted in accordance with EPA approved protocols
(such as those contained in the Pesticide Assessment Guide-
lines I/) or data collected under the approved protocols of
the Organization for Economic Cooperation and Development
(OEOD). If registrants do not wish to develop data in support
of certain uses appearing in their labeling, they may delete
those uses at the time they submit revised labeling.
For certain kinds of testing (generally ecological effects) ,
EPA requires the test substance to be a "typical formulation,"
and in those cases EPA needs data of that type for each
major formulation category (e.g., emulsiTiable concentrates,
wettable "powders, granulars, etc.) These are classified as
generic data and when needed are specified in Table A. EPA
may possess data on certain "typical formulations" but not
others.
2. Options Available for Complying With Requirements to Submit
Data. Within 90 days of receipt of this Standard, registrants
must submit to EPA a completed copy of the form entitled
"FIFRA Section 3(c)(2)(B) Summary Sheet," EPA Form 8580-1
(Appendix E) , for each of their products. On that form,
registrants must state which of the following methods they
will use to comply with the requirements of this Standard:
a. Notify EPA that they will submit the data, and either
submit the existing data they believe will satisfy the
i/ The Pesticide Assessment Guidelines are available in hard
copy or microfiche from the National Technical Info'rmation
Service, 5285 Port Royal Road, Springfield, VA 22161.
23
-------
requirement, or state that they will generate the data
by conducting testing. If the test procedures they will
use deviate from (or are not specified in) the Pesticide
Assessment Guidelines or protocols contained in the
Reports of Expert Groups to the Chemicals Group, Organi-
zation for Economic Cooperation and Development (OECD)
Chemicals Testing Programme, they must enclose the proto-
cols they will use.
OR
Notify EPA that they have entered into an agreement with
one or more other registrants to jointly develop (or
share in the cost of developing) the data. If they
elect this option, they must notify EPA which registrant s)
are parties to the agreement.
OR
File with EPA a completed "Certification of Attempt to
Enter Into an Agreement With Other Registrants for Develop-
ment of Data," EPA Form 8580-6 (Appendix F)I/
OF
Request that EPA amend their registrations by deleting
the uses for which the data are needsd. (This option is
not available to applicants for new products.)
OR
Request voluntary cancellation of the registration(s) of
the products for which the data are needed. (This option
is not available to applicants for new products.)
I/ FIPRA sec. 3(c)(2)(6) authorizes Joint development of data
by two or more registrants, and provides a mechanism by which
parties can obtain an arbitrator's decision if they agree
to jointly develop data but fail to agree on all the terms
of the agreement. The statute does not compel any registrant
to agree to develop data jointly. In EPA's opinion, joint
data development by all registrants subject to a data require-
ment or a cost-sharing agreement among all such registrants
is clearly in the public interest. Duplication of testing
could increase costs, tie up testing facilities, and subject
an unnecessarily large number of animals to testing.
(Footnote continued on next page)
-------
Procedures for Requesting Changes in Testing Methodology and
Extensions of Time. EPA recognizes that registrants may
disagree with the Agency's conclusions regarding the appro-
priate ways to develop the required data or how quickly the
data must be submitted. If the test procedures a registrant
plans to use deviate from (or are not specified in) the
registration guidelines or protocols contained in the reports
of the Expert Groups to the Chemical Groups, Organization
for Economic Cooperation and Development (OECD) Chemicals
Testing Programme, the registrant must submit the protocol
for Agency review prior to the initiation of the test.
If a registrant believes it will need more time to generate
the required data than is allowed by EPA's schedule, the
registrant may submit a request for an extension of time.
The extension request must be submitted in writing to the
Product Manager. The extension request should state the
reasons why the registrant believes that an extension is
appropriate. While EPA considers the request, the registrant
must strive to meet the deadline for submitting the required
data.
(Footnote continued from previous page)
As noted earlier, EPA has discretion to suspend the
registration of a product when a registrant fails to submit
data required under FIPRA Section 3(c)(2)(B). EPA has
concluded that it should encourage joint testing rather than
duplicatlve testing, and that suspension should be withheld
in certain cases to further this goal. Accordingly, if (1) a
registrant has informed EPA of its intent to develop and
submit data required by this JVotice; and (2) a second registrant
informs EPA that it has made a bona fide offer to the first
registrant to share in the expenses of the testing [on terms
to be agreed upon or determined by arbitration under PIPRA
Section 3(c){2)(B)(lii)j; and (3) the first registrant has
declined to agree to enter into a cost-sharing agreement, EPA
will not suspend the second firm's registration.
25
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TABLE A
GENERIC DATA RFBUIREMEWTS FOR ORYZALIN
Guideline Citation and Test
Name of Test Substance!/
§158.120 Product Chemistry
Product Identity
61-2 - Description of beginning materials
and manufacturing process
61-3 - Discussion of formation of
impurities
Analysis and Certification of Product
Ingredients
62-1 - Preliminary analysis
Physical and Chemical Characteristics
63-2 - Color
63-3 - Physical state
63-'» - Cdor
63-5 - Melting point
63-6 - Boiling point
63-7 - Density, bulk density, or
TfiAI
TGAI
THAI
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
Guidelines
Status
R
R
CR
R
R
R
R
R
R
Are Data Footnote
Required Number
Yes No
[X]
CD
[X]
["]
o
n
[J
O
m
n 3
. [X]
n M
[X]
m
[X]
[X]
[X]
n 5
Data Must Be
Submitted Within
Time Frames
Listed Below2./
13 months
7 months
7 months
specific gravity
ro
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TABLE A
OF.NERIC DATA RBQUIREMEMrS FOR ORYZALIN
Guideline Citation and
Name of Test
Test Guidelines
Substance!/ Status
Are Data
Required
Yes No
Footnote
Number
E&ta must Be
Submitted Within
Time Frames
Listed Below^/
§158.120 Product Chemistry (Continued)
Physical and Chemical Characteristics
(Continued)
63-8 - Solubility TGAI or PAI R
63-9 - Vapor pressure PAI R
63-10 - Dissociation constant PAI R
63-11 - Octanol/water partition PAI R
coefficient
63-12 - pH TGAI R
63-13 - Stability TGAI R
Other Requirements:
64- 1
- Submittal of samples TGAI, PAI CR
[X]
[X]
n
n
[X] 6
[X]
[~] 5
n 5
[X]
n 5
[X]
7 months
7 months
7 months
7 months
I/ TGAI = Technical Grade of the Active Ingredient; PAI = Pure Active Ingredient; R = Required; CR = Conditionally
Required.
2/ Data must be submitted within the indicated time frame, based on the date of issuance of the Standard.
3/ Additional information needed to fill data gap.
5/ Analyses for impurities must determine all impurities occurring at 0.1% or higher.
5/ Not reported.
?>/ Need temperature at which solubilities were determined.
ro
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TABLE A
GENERIC DATA REQUIREMENTS TOR ORYZALIM
Data Requiranents
Does EPA Have Data
To Satisfy This
V Requirement? (Yes,
Composition No, or Partially)
Bibliographic
Citation
Mist Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Time Frames For Data
Submission
§158.125 Residue Chemistry
171-4 - Nature of Residue (Metabolism)
- Plants PAIRA, TGAI
- Livestock
171-'J - Residue Analytical Method
- Plant residues
- Animal residues
- Storage Stability Data
171-1 - Magnitude of the Residue-
Residue Studies for Each
Food Use
--field trials
—processed food/feed
PAIRA, TGAI and Plant
Metabolites
THAI and Metabolites
TGAI and Metabolites
PAI
TEP
EP
No
No
Partially
Mo
Partially
No
00239QO
0033976
00106730
00106730
00106730
Yes2/ - 18 months
Ye si/ - 1R months
No!/
No!/
Yes - 18 months
Yes - 2H months
I/ Composition: TGAI = Technical grade of the active ingredient; EP = End-use product; PAIRA = Pure active
ingredient radiolabeled; PAI = Pure active ingredient; TEP = Typical end-use product.
2/ The metabolism of oryzalin in plants and animals is not adequately understood. Data are required on soybeans and
potatoes, ruminants and chickens.
37 Additional methods may be required pending the results of the metabolism studies. This would include methods for
crops, by-products, meat, milk, poultry and eggs.
CO
CD
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ORYZALIN
Does F.PA Have
Data To Satisfy
I/ Use 2/ This Require-
Data Requirement Composition Pattern ment? (Yes, No
or Partially)
§158.115
71-1 -
71-2 -
71-3 -
71-4 -
71-5 -
72-1 -
72-2 -
72-3 -
Wildlife and Aquatic Organisms
Avian Single-Dose THAI AB Yes
Avian Dietary TGAI MSF^/G^/ Yes
Wild Mammal Toxiclty N/A N/A
Avian Reproduction TGAI AB Yes
Simulated and Actual TEP N/A
Field Testing for
Mammals and Bird
Fish Acute Toxlcity TGAI ABPi[/GA/ Yes
Acute Toxiclty Aquatic TGAI ABFG Yes
Invertebrates
Acute Toxic ity TGAI A No
Bibliographic
Citation
00098462?/
00106728J/
00106278"/
00072593Z/
000725941/
00126813
00129050
00072595?/
001066635/
00106729°/
000725961/
Must Additional Data
89 Submitted Under
FIFRA § 3(c)(2)(B)?
Time Frame for Data
Submission 3/
No
Noi/
No
No
No
Reserved^/
Estuarine and Marine
Organisms
ro
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TABLE A
GF.NERIC DATA REQUIREMENTS FOR ORYZALIN
I/
Data Requiranent
Composition
Use 2/
Pattern
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Mast Additional Data
Be Submitted Under
PffRA § 3(c)(2)(B)?
Time Frane for Data
Submission 3/
§158.145 Wildlife and
Aquatic Organisms (continued)
72-1 - Fish Early Li^e Stage TGAI
Aquatic Invertebrate
Life-Cycle
72-5 - Fish - Life-Cycle TCP
72-6 - Aquatic Organism TEP
Accumulation
72-7 - Simulated or Actual TEP
Field Testing for
Aquatic Organisms
AB
N/A
N/A
AB
Yes
001268*41!/
00126812Z/
No
00106665§/
Reservedly
Reserved^/
Reserved^/
Reserved^/
_!/ Composition: TGAI = Technical grade of the active ingredient; TEP = Typical end-use product; EP = End-use product.
2/ The use patterns are coded as follows: A = Terrestrial, Food Crop: B = Terrestrial, Non-Food Crop: C = Aquatic, Food
Crop; D = Aquatic, Non-Food; E = Greenhouse, Food Crop; F = Greenhouse, Non-Food; G = Forestry; H = Domestic Outdoor:
I = Indoor, N/A = Not Applicable.
V Data must be submitted no later than 18 months after reserved studies are required.
V Only one species is required to support a manufacturing-use product.
5/ Not required at this time.
5/ Reserved pending evaluation of complete environmental fate data.
7/ Study fulfills guideline requirement on its own.
H/ Study does not fulfill guideline requiranent on its own.
UJ
o
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TABLF A
GENERIC DATA RRQIUREMENTS TOR ORYZALIN
Data Requlranent
I/ Use 2/
Composition Pattern
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Time Frame for Data
Submission !/
§158.155 Nontarget Insect
Nontarget Insect Testing -
Pollinators
- Honey bee acute
contact toxic ity
- Honey bee - toxicity
of residues on
Pol iage
141-3 -
141-4
141-5
Wild bees Important
in alfalfa pollination -
toxicity of residues on
foliage
THAI
TEP
TCP
ABG.
ABO
Yes
No
00066320
No
No5/
Honey bee subacute
feeding study
Field testing for
pollinators
(Reserved)^/
TCP
-------
TABLF. A
GENERIC DATA REQUIREMEOTS FDR ORYZALIN
I/
Data Requirement
Composition
Use 2/
Pattern
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIPRA § 3(c)(2)(B)?
Time Frame for Data
Submission 37
§158.155 Montarget Insect (continued)
Nontarget Insect Testing -
Aquatic Insects
1*12-1 - Acute toxicity to
aquatic insects
-1 - Aquatic insect
life-cycle study
142-3 - Simulated or actual
field testing for
aquatic insects
-1 - Nontarget Insect
Testing - Predators
and Parasites
(Reserved)^.
(Reserved) I/
(Reserved)^/
(Reserved)^/
\J Composition: TGAI = Technical grade of the active ingredient; TEP = Typical end-use product.
2_/ The use patterns are coded as follows: A=Terrestrlal, Food Crop; B=Terrestrial, Non-Food: C=Aquatlc, Food Crop:
D=Aquatlc, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food: G=Forestry; H=Domestic Outdoor: I=Indoor.
3/ Data must be submitted no later than 12 months after reserved studies are required.
V Requirement reserved pending development of test methodology.
5/ Based on the results of the acute toxicity study, there is sufficient information to characterize oryzalin as
of very low toxicity to honeybees. Therefore, this study is not required.
U)
ro
-------
TABLE A
GENERIC DATA REQUIREMENTS PQR ORYZALIN
Does EPA Have
Data To Satisfy
I/ Use 2/ This Requlre-
Data Requiranent Composition Pattern ment? (Yes, No
or Partially)
§158.135 Toxicology
Acute Testing
81-1 - Acute Oral Toxicity - Rat THAI ABPG Yes
81-2 - Acute Dermal Toxicity THAI ABIT, Yes
81-3 - Acute Inhalation Toxicity TGAI ABFH Yes
81-4 - Primary Eye Irritation TGAI ABFU Yes
- Rabbit
81-5 - Primary Dermal TGAI ABFG Yes
Irritation - Rabbit
Bibliographic
Citation
00026592
00026084
00106667
00106666
00038668
00026757
00094414
00106681
00041970
00026769
00027289
00106660
00038673
00088513
00106681
00041970
00094414
00106664
00038672
Must Additional Data
Be Submitted Under
PIFRA § 3(c)(2)(B)?
Time Frame for Data
Submission
No
No
Mo
No
No
UJ
OJ
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ORYZALIN
V
Data Requirement Composition
Use 2/
Pattern
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Time Frame for Data
Submission
§158.135 Toxicology (continued)
Acute Testing (continued)
8l-6
8l-7
- Dermal Sensltization
- Guinea PJg
- Acute Delayed
Neurotoxicity - Hen
TGAI
TGAI
ABFG
N/A
Yes
No
00026762
No
Nol/
Subchronic Testing
82-1
82-2
82-3
82-1
82-5
- 90-Day Feeding -
Rodent
Non- rodent (Dog)
- 21-Day Dermal - Rabbit
- 90-Day Dermal
- 90-Day Inhalation
- 90-Day Neurotoxicity
TGAI
TGAI
TGAI
TGAI
TGAI
TGAI
AB
AB
AB
N/A
N/A
N/A
Yes
Yes
Yes
No
to
No
00038677
00026773
00106670
00106661
00038662
No
No
No
Nol/
Nol/
Nol/
- Hen
-------
TABLF. A
GENFRIC DATA REQUIREMENTS FOR ORYZALIN
Data Requirement
Does EPA Have
Data To Satisfy
I/ Use 2/ This Require-
Composition Pattern ment? (Yes, No
or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIPRA § 3(c)(2)(B)?
Time Frame for Data
Submission
§138.135 Toxicology (continued)
Chronic Testing
83-1 - Chronic Toxicity -
- Rodent TGAI
- ton-rodent (Dog) TGAI
83-2 - Oncogenlcity -
- Rat TGAI
- Mouse TGAI
83-3 - Teratqgenicity -
- Rat TGAI
- Rabbit TGAI
AB
AB
AB
AB
AB
AB
Yes
to
Yes
Yes
Yes
Yes
00026776
00038681
00044332
00070569
00068079
00026780
00038682
00026781
00073552
00098U61
No
Yes - 50 months
No
Mo
No
No
LO
on
-------
TABLE A
GENERIC DATA REQUIREMENTS TOR ORYZALIM
I/ Use 2/
Data Requirement Composition Pattern
§158.135 Toxicology (continued)
83-4 - Reproduction TGAI AB
Mutageniclty Testing
84-2 - Gene Mutation TGAI AB
84-? - Chromosomal Aberration TGAI AB
84-4 - Other Genotoxic Effects TGAI AB
DNA
Special Testing
85-1 - General Metabolism PAI or PAIRA AB
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Yes
No
Yes
Yes
Yes
Bibliographic
Citation
00042908
.00026782
00038150
00042910
0004291 1
00130427
GS0186010
00115743
00138696
00086801
00087801
00026761
00084886
00026592
00098U63
Must Additional Data
Be Submitted Under
FIPRA 5 3(c)(2)(B)?
Time Frame for Data
Submission
No
YesV - 9 months
Yes - 12 months
Yes - 12 months
No
-------
TABLE A
GENERIC DATA R5QUIRKMEMTS TOR ORYZALIN
Data Requiranent
Does EPA Have Data
To Satisfy This
I/ Use2/ Requirement? (Yes,
Composition"" Pattern No or Partially)
Bibliographic
Citation
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)
Time Frames for Data
Submission
Toxicology (continued)
Special Testing (continued)
86-1 - Domestic Animal
Safety
Additional Testing
Human Exposure
Choice
AB
Yes
THAI and
Formulated
Products
N/A
No
0010666?
00106666
00026592
0003877^
00026788
00066198
00026081
No
No
§158.135 Toxicology (continued)
!_/ Composition: TGAI = Technical Grade Active Ingredient; PAI = Pure active Ingredient; PAIRA = Pure active ingredient,
radiolabelled. As formulated = SurfIan 75W; Surflan 4 AS; SurfIan AS.
2/ The use patterns are coded as follows: A=Terrestrlal, Food Crop; B=Terrestrlal, Non-Food; G=Aquatic, Food Crop;
D=Aquatic, Non-Food; E=Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=Forestry; H=Domestic Outdoor; I=Indoor.
3/ The data requirenent is Inapplicable to this product.
"5/ Data may be upgraded to be acceptable on resolution of the reporting deficiencies described In the text.
oo
-------
TABLK A
GENERIC DATA REQUIREMENTS TOR ORYZALIN
Data Requirement
Composition
I/
Use 2/
Pattern
Does EPA Have
Data To Satisfy
This Require-
ment? (Yes, No
or Partially)
Bibliographic
Citation
Mist Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Time Frame for Data
Submission
§158.130 Environmental Fate
Degradation Studies-Lab
161-1 - Hydrolysis
Photodegradatlon
161-2 - In water
161-3 - Ch soil
161-4 - In Air
Metabolism Studies-Lab
162-1 - Aerobic Soil
162-2 - Anaerobic .Soil
162-3 - Anaerobic Aquatic
162-1 - Aerobic Aquatic
TGAI or PAIRA
ABFG
TGAI or PAIRA ABG
TGAI or PAIRA AG
TGAI or PAIRA F
TGAI or PAIRA ABPG
TGAI or PAIRA A
TGAI or PAIRA G
TGAI or PAIRA N/A
No
No
No
No
No
No
No
N/A
Yes - 9 months
Yes - 9 months
Yes - 9 months
Yes - 9 months
Yes - 27 months
Yes - 27 months
Yes - 27 months
N/A
t_o
co
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ORYZALIN
Data Requirement
I/
Composition
Use 2/
Pattern
Does EPA Have
Data To Satisfy
This Require- Bibliographic
ment? (Yes, No Citation
or Partially)
Must Additional Data
Be Submitted Under
FIFRA § 3(c)(2)(B)?
Time Frame for Data
Submission
§158.130 Environmental Fate (continued)
Mobility Studies
163-1 - Leaching and
Adsorption/Desorption
163-2 - Volatility (Lab)
163-3 - Volatility (Field)
Dissipation Studies-Field
164-1 - Soil
164-2 - Aquatic (Sedknent)
164-3 - Forestry
164-4 - Combination and
TGAI or PA IRA
TEP
TEP
TEP
TEP
TEP
ABFT,
F
F
ABO
N/A
G
N/A
No
No
No
No
N/A
No
N/A
Yes - 12 months
Yes - 12 months
No
Yes - 27 months
N/A
Yes - 27 months
N/A
Tank Mixes
164-5 - SoH, Long-term
TEP
AB
No
Conditional!/
-------
TABLE A
GENERIC DATA RRQUIRFMF.NTS FOR ORYZALIN
I/
Data Requlranent Composition
§158.130
Environmental Pate (continued)
Use 2/
Pattern
Does F.PA Have
Data To Satisfy
This Require- Bibliographic
inent? (Yes, No Citation
or Partially)
Must Additional Data
Be Submitted Under
FIFRA 5 3(c)(2)(B)?
Time Frame for Data
Submission
Accumulation Studies
165-1
165-2
165-3
165-4
165-5
- Rotational Crops PAIRA
(Confined)
- Rotational Crops TEP
(Field)
- Irrigated Crops TEP
- In Fish TGAI or PAIRA
- In Aquatic Non-Target TEP
Organisms
Sub-Part .K - Reentry
Ground
Water Assessment
A
A
N/A
ABG
G
N/A
N/A
No
No
N/A
No
No
N/A
No
Yes -
39 months
Conditional^!/
N/A
Yes -
Yes -
N/A
Yes5/
12 inonths
12 months
\l Composition: TGAI = Technical grade of the active ingredient: PAIRA = Pure active ingredient, radiolabelled;
TEP = Typical end-use product.
2/ The use patterns are coded as follows: A=Terrestrial, Food Crop: B=Terrestrial, Non-Food; C=Aquatic, Food Crop;
D=Aquatic, Non-Fbod; E^Greenhouse, Food Crop; F=Greenhouse, Non-Food; G=R>restry; H=Domestic Outdoor; I=Indoor.
jr
O
-------
TABLE A
GENERIC DATA REQUIREMENTS FOR ORYZALIN
§158.130 Environmental Fate (continued)
3/ Required unless soil residues greater than 50% of initial application of time of subsequent application. Consult
with Agency upon completion of aerobic soil metabolism study, to determine appropriate tlmeframe for conducting
study.
V Required if residues of toxlcological concern are detected in the test crops of confined study.
5_/ Hydrolysis, aerobic soil metabolism, octanol water, vapor pressure, water solubility, photodegradation, mobility,
and field dissipation are required.
-------
E. INSTRUCTIONS FOR SUBMISSION. This section describes what
must be submitted and the time frame3 for the submissions.
Addresses are provided at the end of this section.
1. Requirements
a. For Manufacturing-Use Products Containing Qryzalin
as Sole Active Ingredient
(1) Within 90 days from receipt of this Standard,
registrants must submit the "FIFRA Section
3(c)(2)(B) Summary Sheet," EPA Form 8580-1
(Appendix E).
(2) Within 6 months from receipt of this Standard,
registrants must submit:
(a) Confidential Statement of Formula, EPA
Form 8570-4.
(b) Two copies of draft labeling, including the
label and associated brochures. If current
labeling conforms to the requirements of this
Standard and the results of the short-term
data, such labeling must be submitted. The
labeling should be either typewritten text
on 8-1/2 x 11 inch paper or a mockup of the
labeling suitable for storage in 8-1/2 x 11
inch files. The draft label must indicate
the Intended colors of the final label, clear
indication of the front panel label, and the
Intended type sizes of the text.
(c) Evidence of compliance with data support
requirements of PIPRA sec. ' 3(c)(1)(D). Refer
to 40 CFR 152.80-152.99 for latest requirements.
(3) Within the times set forth in Table A, registrants
must submit all generic data, unless they are
eligible for the formulator' s exemption.
b . For Manufacturing Use Products Containing Qryzalin in
Combination With Other Active Ingredients
(I) Viithin 90 days from receipt of this Standard,
registrants must submit the "FI?RA Section 3(c)(2)(B)
Summary Sheet," EPA Form 8530-1 (Appendix E).
(2) Within the times set forth in Table A, registrants
must submit all generic data, unless they are
eligible for the formulator's exemption.
-------
c. For End-Use Products Containing Oryzalin Alone or In
Combination With Other Active Ingredients
(1) Within 90 days from receipt of this Standard,
registrants must submit the "FIFRA Section
3(c)(2)(B) Summary Sheet," EPA Form 8580-1
(Append!x E).
(2) Within 6 months from receipt of this Standard,
registrants must submit:
(a) Confidential Statement of Formula, EPA
Form 8570-4 .
(b) Two copies of draft labeling, including the
label and associated brochures. If current
labeling conforms to the requirements of this
Standard and the results of the short-term
data, such labeling should be submitted. End-
use product labeling must comply specifically
with the instructions in this Standard. Label-
ing should be either typewritten text on
8 1/2 x 11 inch paper or a mockup of the label-
ing suitable for storage in 8 1/2 inch files.
The draft label must indicate the intended
colors of the final label, clear indication
of the front panel label, and the intended
type sizes of the text.
(-3) Within the time frames set fo rth in Table A,
registrants must submit all generic .data, unless
they are eligible for the formulator's exemption.
d. products Qualifying for Formulator's Exemption.
Within 90 days from receipt of this Standard,
registrants must submit a Formulator's Exemption
Statement, Appendix G. They must also submit
a current Confidential Statement of Formula
or certify that the Confidential Statement of
Formula on file is complete, current and accurate.
Submissions to Product Manager. Applications and other
required information should be submitted to the Product
Manager, Registration Division. If, for any reason, any
test is delayed or aborted so that the agreed schedule
cannot be met, the Product Manager must be notified.
The address for submissions to the Product Manager is:
-------
Mr. Robert J. Taylor
Product Manager
Registration Division (TS-767C)
Office of Pesticide Programs
Environmental Protection Agency
401 M St., SW.
Washington, D.C. 20460
Phone No. (703) 557-1800
Submissions to the Office o£ Compliance Monitoring. If,
on the FIFRA Section 3(c)<2)(8) Summary Sheet, a registrant
commits to develop the data, requests a minor chemical
exemption, presents arguments that a data requirement is
not applicable, or submits protocols or modified protocols
for Agency review, the registrant must also submit a copy
of the Summary Sheet (and any supporting information) to
the Office of Compliance Monitoring, which will be monitor-
ing the data generated in response to this Standard.
Actual studies are not to be submitted.
If for any reason any test is delayed or aborted so that
the agreed schedule cannot be met, the Office of Compliance
Monitoring must also be notified.
The address for submission to the Office of Compliance
Moni tor ing is:
Laboratory Data Integrity Projram
Office of Compliance Monitoring (EN-342)
Environmental Protection Agency
401 M St., SW.
Washington, D.C. 20460
-------
APPENDIX A
EPA INDEX TO PESTICIDE CHEMICALS
ORYZALIN
-------
EPA Index to Pesticide Chemicals
H104201 ORYZALIN*
TYPE PESTICIDE; Herbicide
FORMULATIONS;
WP(75%~5
EC (1.5 Ib/gal, 2 Ib/gal)
F1C (4 Ib/gal)
GENERAL WARNINGS AND LIMITATIONS: A selective, surface-applied herbi-
cide for preemergent control of most annual grasses and certain broadleaf
weeds. Oryzalin will not control established weeds. Existing weeds must
be destroyed prior to application. Chop and thoroughly mix crop residues
into the soil to a depth of at least 4 to 6 inches by deep plowing or
discing, and break up large clods. A 0.5 inch of rain or its equivalent
in center pivot or sprinkler irrigation is necessary to activate oryzalin.
If weeds begin to emerge, shallow cultivate 1 to 2 inches to destroy ex-
isting weeds and place oryzalin in the zone of weed seed germination. If
heavy rains pack the soil surface, use a rotary hoe to break the crust to
aid crop emergence. Silty clay loams and sandy clay loams are transi-
tional soils and may be classified as either medium or heavy textured
soils. Unless otherwise specified, use the lower dosage on coarse and
medium textured soils, and the higher dosage on fine textured soils.
Oryzalin is not recommended for use on soils containing more than 5 per-
cent organic matter. Make only 1 application per season. Dosages are
expressed as pounds a.i. broadcast rate per acre. For band applications,
reduce dosage in proportion to band area actually treated. When tank
mixes are used, observe all precautions and limitations given on the
labeling of tank mix chemicals. Apply in 20 to 40 gallons of water per
acre by ground or 2 to 10 gallons by air, unless otherwise specified.
•Definition of Terms;
a.i. - active ingredient
TIME REQUIRED FOR CONTROL; Not located.
PHYTOTOXICITY TO TARGET WEEDS; Not located.
PHYTOTOXICITY TO CROPS: Not located.
MODE OF ACTION; Inhibits both root and shoot growth when absorbed by the
roots of germinating plants.
*Surflan
3 ,5-dinitro-N4,N4-dipropylsulfanilamide
Issued: 1-17-84 1-104201-1
-------
EPA Index to Pesticide Chemicals
ORYZALIN
BROADLEAF WEEDS CONTROLLED:
PBFDCBC Annual sowthistle
PBKAIAA Bittercress
PBKAFBF Black mustard
PEWAIBE Black nightshade
PADABBA Carpetweed
PAZAAAC Chickweed
PAMAIBA Climbing milkweed
PARABBB Coast fiddleneck
PAZAOBB Common chickweed
PBFCXBK Common groundsel
PBDAEBA Common lambsquarters
PDAAKBB Common mallow
PEDADBA Common purslane
PBFAEBA Common ragweed
PDPABBA Creeping woodsorrel
PEMAEBB Florida pusley
PBFAEBE Giant ragweed
PCOAFBA Henbit
PBFAVBA Horseweed
PEAAGBP Ladysthumb
PBDAEAB Lambsquarters
PBKBDBB London rocket
PEMAZAA Mexican clover
PBGAAAB Moruingglory
PEAAGBO Pennsylvania smartweed
PAAAABI Pigweed
PBFCEBF Prickly lettuce
PDAAJBF Prickly sida
PEAAGBD Prostrate knotweed
PAFACBC Prostrate pigweed
PBVAGBQ Prostrate spurge
PFMAFBB Puncturevine
PAAAABP Purslane
PEDABBA Redmaids rockpurslane
PAFACBI Redroot pigweed
PBZABBB Redstem filaree
PEDABAA Rockpurslane
PAFACAB Rough pigweed
PBKAHBA Shepherdspurse
PEAAGAD Smartweed
PAFACBE Smooth pigweed
PAFACBJ Spiny amaranth
PBVAGBK Spotted spurge
PAFACBA Tumble pigweed
PDAABBB Velvetleaf
PBZABBC Whitestem filaree
PBKAFBE Wild mustard
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a)
(a) Partial control or suppression only.
(b) Provides control on fine textured soils in cotton at 1.5 Ib
a.i./A.
Issued: 1-17-84
1-104201-2
-------
EPA Index to Pesticide Chemicals
ORYZALIN
GRASSES AND OTHER MONOCOTS CONTROLLED:
PCACKBA Annual bluegrass
PCABHBB Barnyardgrass
PCACEBE Browntop panicum (b)
PCAAUBA Buffalograss (b)
PCABFAA Crabgrass
PCABCBA Crowfootgrass
PCABLAA Cupgrass
PCACEBD Fall panicum
PCAAWBB Field sandbur
PCACUAA Foxtail
PCACUBA Giant foxtail
PCAB1BA Goosegrass
PCACUBF Green foxtail
PCABZBA Italian ryegrass
PCACWBG Johnsongrass (seedling)
PCABHBA Junglerice
PCABFBF Large crabgrass
PCABSBF Little barley
PCABKBE Mexican lovegrass
PCABKBK Orcutt lovegrass
PCABYBB Red sprangletop
PCACCBA Rice
PCACUAC Robust foxtail
PCAARAA Signalgrass
PCABFBD Smooth crabgrass
PCABLBA Southwestern cupgrass
PCACEBL Texas panicum (b)
PCADFBA Wheat (volunteer) (a)
PCAAOBB Wild oat
PAAAABC Wiregrass
PCACEBC Witchgrass
PCACUBD Yellow foxtail
(a) Partial control or suppression only.
(b) Provides control on fine textured soils in cotton at 1.5 Ib
a.i./A.
Issued: 1-17-84
1-104201-3
-------
EPA Index to Pesticide Chemicals
ORYZALIN
/U3001AA
/04001AA
/0400IDA
/04003DA
/05002DA
Site, Dosage
and Formulation
(Ib a.i./A)
Tolerance, Use, Limitations
TERRESTRIAL FOOD CROP
(Agricultural Crops)
General Warnings and Limitations; Do not apply to newly transplanted
fruit and nut trees, or vineyards until the soil has settled and there
are no cracks present. Do not apply via center pivot irrigation systems
to fruit and nut orchards or vineyards. In CA do not apply to non-dor-
mant fruit and nut orchards or vineyards through overhead sprinkler
irrigation systems.
Almond
2-6
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal F1C)
Apple
2-6
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal.F1C)
0.05 ppm (nuts and almond hulls)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with dichlobenil; paraquat di-
chloride; simazine; glyphosate, isopropylamine
salt; norflurazon; or oxyfluorfen.
0.05 ppm (pone fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with terbacil; dichlobenil;
diuron; paraquat dichloride; simazine; glyphosate,
isopropylamine salt; or norflurazon.
Apple (nursery scock) N.F.
Bartlett Pear
(nursery stock)
Cherry (nursery
scock)
2-4
(75% WP)
(4 Ib/gal F1C)
Broadcast. Apply as an over-the-top or directed
spray. Use 2 Ib a.i./A for control to last for 2
to 4 months, and 4 Ib a.i./A for 6 to 8 months.
Apply only to established plantings. Rooted lin-
ers should be established in containers 2 weeks
prior to treatment or crop injury may occur.
Directed spray may be tank mixed with glyphosate,
isopropylamine salt.
Issued: 1-17-84
1-104201-4
-------
/05001AA
Site, Dosage
and Formulation
(Ib a.i./A)
Apricot
2-6
(75% WP)
(4 Ib/gal F1C)
/06001AA
Avocado
2-6
(75% WP)
(4 Ib/gal FIG)
/01002AA
/01009AA
Bartlett Pear
(nursery stock)
Blackberry
Blueberry
2-6
(75% WP)
(4 Ib/gal F1C)
/01003AA
Boysenberry
2-6
(4 Ib/gal F1C)
Cherry (nursery
stock)
EPA Index to Pesticide Chemicals
ORYZALIN
Tolerance, Use, Limitations
0.05 ppm (stone fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with paraquat dichloride;
norflurazon; or oxyfluorfen.
0.05 ppm
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with paraquat dichloride; sim-
azine; or glyphosate, isopropylamine salt.
See Apple (nursery stock) cluster.
0.05 ppm (small fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control, to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with terbacil; dichlobenil;
diuron; paraquat dichloride; or simazine.
0.05 ppm (small fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with terbacil; diuron; paraquat
dichloride; or simazine.
See Apple (nursery stock) cluster.
Issued: 1-17-84
1-104201-5
-------
EPA Index to Pesticide Chemicals
ORYZALIN
/05002AA
/28007AA
/01011AA
/01012AA
/01004AA
Site, Dosage
and Formulation
(Ib a.i./A.)
Tolerance, Use, Limitations
Cherry (Sour, Sweet) 0.05 ppn (stone fruits)
2-6
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal F1C)
Cotton
1-1.5
(75% WP)
(4 Ib/gal FIG)
Currant
Elderberry
2-6
(4 Ib/gal F1C)
Dewberry
2-6
(75% WP)
(4 Ib/gal F1C)
Elderberry
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
Hay be tank mixed with dichlobenil; paraquat di-
chloride; simazine; glyphosate, isopropylamine
salt; or norflurazon.
0.05 ppm (cottonseed)
Do not feed forage from treated fields to live-
stock. Do not plant any root crop for 12 months
following an application.
Use limited to TX. Preemergence. Broadcast.
Apply at planting or within 2 days after planting.
Use the lower dosage on medium textured soils and
the higher dosage on fine textured soils. May be
applied by air.
0.05 ppm (small fruits)
Directed spray. Broadcast or band application no
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
0.05 ppm (small fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and b
Ib a.i./A for 8 to 12 months.
May be tank mixed with terbacil; diuron; or sima-
zine.
See Currant cluster.
Issued: 1-17-84
1-104201-6
-------
/03009AA
/04003AA
/06005AA
/03005AA
/01013AA
/01014AA
Site, Dosage
and Formulation
(Ib a.i./A)
English Walnut
Pear
2-6
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal F1C)
lift
2-6
(75% WP)
(4 Ib/gal F1C)
Filbert
2-6
(75% WP)
(4 Ib/gal F1C)
Gooseberry
2-6
(4 Ib/gal F1C)
Grapes
2-6
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal F1C)
EPA Index to Pesticide Chemicals
ORYZALIN
Tolerance, Use, Limitations
0.05 ppm (nuts, pome fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with dichlobenil; diuron; para-
quat dichloride; simazine; glyphosate, isopropyl-
amine salt; or norflurazon.
0.05 ppm
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with paraquat dichloride.
0.05 ppm (nuts)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with dichlobenil; paraquat di-
chloride; simazine; norflurazon; or oxyfluorfen.
0.05 ppm (small fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with diuron.
0.05 ppm (small fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with dichlobenil; diuron; or
simazine.
Issued: 1-17-84
1-104201-7
-------
/02002AA
/02004AA
/02006AA
/06018AA
/06015AA
/01005AA
/03007AA
Site, Dosage
and Formulation
(Ib a.i./A)
Grapefruit
Lemon
Orange
2-6
(75% WP)
(4 Ib/gal F1C)
Kiwi Fruit
Pomegranate
2-6
(75% WP)
(4 Ib/gal F1C)
Lemon
Loganberry
2-6
(4 Ib/gal F1C)
Macadamia Nut
2-6
(4 Ib/gal FIG)
EPA Index to Pesticide Chemicals
ORYZALIN
Tolerance, Use, Limitations
0.05 ppm (citrus fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12'months.
May be tank mixed with bromacil; terbacil; diuron;
paraquat dichloride; simazine; glyphosate, iso-
propylamine salt; norflurazon; or bromacil and
terbacil.
0.05 ppm (kiwifruits, pomegranates)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
See Grapefruit cluster.
0.05 ppm (small fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with terbacil; diuron; or sima-
zine.
0.05 ppm (nuts)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with diuron; or simazine.
Issued: 1-17-84
1-104201-8
-------
/28012AA
/05003AA
Site, Dosage
and Formulatioa
Ub a.i./A)
Mint (Peppermint,
Spearmint)
1-1.5
(75% WP)
(4 Ib/gal FIG)
1-1.5
(75% WP)
(4 Ib/gal F1C)
1-1.5
(4 Ib/gal F1C)
1-1.5
(4 Ib/gal F1C)
Nectarine
2-6
(75% WP)
(4 Ib/gal F1C)
EPA Index to Pesticide Chemicals
ORYZALIN
Tolerance, Use, Limitations
0.05 ppm (hay)
0.1 ppm (oil)
General Information: Deep plow prior to planting
rotational crops within 15 months of application.
Do not apply to mint growing under adverse condi-
tions or to mint weakened by severe winter injury.
Preharvest or postharvest. Broadcast application
for use on coarse and medium textured soils. Ap-
ply up to 60 days before harvest or to mint stub-
ble any time following harvest in the fall.
Use limited to the Midwest. Preemergence.
Broadcast application. For use on coarse and
medium textured soils. Apply to established mint
just after the last cultivation.
Tank mix with terbacil.
Use limited to the Pacific Northwest (west of the
Cascade Mountains). Preemergence. Broadcast ap-
plication for use on coarse and medium textured
soils. Apply to established mint in the spring
or fall after the last cultivation.
Tank mix with terbacil.
Use limited to the Pacific Northwest (east of the
Cascade Mountains). Preemergence. Broadcast ap-
plication for use on coarse and medium textured
soils. Apply any time after the first settling
rain in the fall, but not when ground is frozen.
If moisture is inadequate to activate the herbi-
cide, irrigation by sprinkler must follow fall or
winter treatment as soon as soil thaws in the
spring, or immediately after spring treatment.
Tank mix with terbacil.
0.05 ppm (stone fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with dichlobenil; paraquat di-
chloride; norflurazon; or oxyfluorfen.
Issued: 1-17-84
1-104201-9
-------
EPA Index to Pesticide Chemicals
ORYZALIN
/06009AA
/05004AA
/28016AA
/03008AA
Site, Dosage
and Formulation
(Ib a.i./A)
Olive
2-6
(752 WP)
(4 Ib/gal F1C)
Tolerance, Use, Limitations
0.05 ppm
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and b
Ib a.i./A for 8 to 12 months.
May be tank mixed with diuron; paraquat dichlor-
ide; or simazine.
See Grapefruit cluster.
0.05 ppm (stone fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2-
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with terbacil; dichlobenil;
diuron; paraquat dichloride; simazine; or oxy-
fluorfen.
Peas (English, Green) 0.05 ppm (peas, succulent)
Do not feed forage from treated fields to live-
stock. Do aot plant any root crop for 12 months
following application.
2-6
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal F1C)
0.5
(4 Ib/gal F1C)
Pecan
2-6
(75% WP)
(4 Ib/gal F1C)
Preplant. Broadcast. Apply up to 2 weeks prior
to planting.
Tank mix with trifluralin.
0.05 ppm (nuts)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with terbacil; dichlobenil;
diuron; paraquat dichloride; simazine; or glypho-
sate, isopropylamine salt.
Issued: 1-17-84
1-104201-10
-------
/03011AA
/05005AA
/14013AA
/05006AA
/01006AA
Site, Dosage
and Formulation
(Ib a.i./A)
Pistachio
2-6
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal F1C)
Plum
2-6
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal F1C)
Pomegranate
Potato (White)
0.73-1
(75% WP)
(4 Ib/gal FIG)
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal F1C)
Raspberry
2-6
(75% WP)
(4 Ib/gal F1C)
EPA Index to Pesticide Chemicals
ORYZALIN
Tolerance, Use, Limitations
0.05 ppm (nuts)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A .for 8 to 12 months.
May be tank mixed with glyphosate, isopropylamine
salt.
0.05 ppm (stone fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and .6
Ib a.i./A for 8 to 12 months.
May be tank mixed with dichlobenil; paraquat di-
chloride; sicaazine; norflurazon; or oxyfluorfen.
See Kiwi Fruit cluster.
0.05 ppm
Preemergence. Broadcast. Where rebedding and
drag-off are standard cultural practices, appli-
cations should be made following drag-off. For
use on coarse and medium textured soils.
May be tank mixed with metribuzin.
0.05 ppm (stone fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with paraquat dichloride; nor-
flurazon; or oxyfluorfen.
0.05 ppm (small fruits)
Directed spray. Broadcast or band application to
orchard floor for short and long term weed con-
trol. Use 2 Ib a.i./A for control to last for 2
to 4 months, 4 Ib a.i./A for 6 to 8 months, and 6
Ib a.i./A for 8 to 12 months.
May be tank mixed with terbacil; dichlobenil;
diuron; paraquat dichloride; or simazine.
Issued: 1-17-84
1-104201-11
-------
/28023AA
Sice, Dosage
and Formulation
(Ib a.i./A)
Soybeans
0.28-0.56
(1.5 Ib/gal EC)
0.28-0.56
(1.5 Ib/gal EC)
0.5-1.25
(75% WP)
0.75-1.5
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal F1C)
0.5-1.25
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal F1C)
0.5-1.25
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal F1C)
EPA Index to Pesticide Chemicals
ORYZALIN
Tolerance, Use, Limitations
0.1 ppm
Do not feed forage or vines from treated fields
to livestock. Do not plant any root crop for 12
months following an application.
General Information; Aerial applications may be
made when oryzalin is applied alone or in tank
mix with linuronj metribuzin; or dinoseb and
naptalam.
Preplant soil incorporation. Apply in the spring
and incorporate into top 1 to 3 inches of the
soil within 3 days after application. Treated
soil may be shallow cultivated without reducing
weed control; do not cultivate deeper than the
treated soil. May be applied in conjunction with
a liquid fertilizer or impregnated on a dry bulk
fertilizer. May be applied by air.
Formulated with trifluralin.
Preplant soil incorporation. Incorporate into
top 1 to 3 inches of the soil within 3 days after
application.
Tank mix with chloramben; or metribuzin.
Formulated with trifluralin.
Use limited to AR, LA, MS and TX. Preplant.
Broadcast or band application for the suppression
of rice. Apply up to 2 weeks prior to planting.
Tank mix with metribuzin.
Preplant or preemergence. Broadcast or band.
Apply from 4 weeks prior to planting up through 2
days after planting.
Preplant or preemergence. Broadcast or band.
Apply from 2 to 4 weeks prior to planting up
through 2 days after planting, but before crop
emerges.
Tank mix with metribuzin.
Preemergence. Broadcast or band. Apply within 2
days after planting, but before crop emergence.
Tank mix with chloramben; linuron; or naptalam
and dinoseb.
Issued: 1-17-84
1-104201-12
-------
EPA Index to Pesticide Chemicals
ORYZALLN
Site, Dosage
and Formulation
(Ib a.i./A)
Soybeans (continued)
1-1.5
(4 Ib/gal F1C)
Tolerance, Use, Limitations
0.75-1.5
(75% WP)
(2 Ib/gal EC)
(4 Ib/gal F1C)
Broadcast or band application. Apply anytime
after harvest in the fall up to spring seeding
and prior to weed germination. Application can
be made directly over undisturbed stubble from
the previous crop. Use the lower rate under light
crop residue conditions and under light weed
pressure. Sequential herbicide applications can
be made in the spring to control escaped broad-
leaf weeds and to provide control of weeds not
controlled by oryzalin. Do not till soil after
oryzalin application and before planting.
Preemergence. Broadcast or band application for
use in no-till soybeans. Apply at planting or
within 2 days after planting. Do not spray over
the top of emerged soybeans.
Tank mix with linuron; metribuzin; linuron and
paraquat dichloride; linuron and glyphosate, iso-
propylamine salt; paraquat dichloride and metri-
buzin; or metribuzin and glyphosate, isopropyl-
amine salt.
TERRESTRIAL NON-FOOD CROP
(Agricultural Crops)
/26005AA Tobacco, Air Cured
(Burley, Maryland,
Dark)
/26006AA Tobacco, Flue Cured
0.5-1
(4 Ib/gal F1C)
N.F.
Do not plant any root crop for 12 months following
application.
Posttransplant. Directed spray. Apply at layby
following the last normal cultivation, usually 4
to 6 weeks after transplanting. Do not allow
spray to contact tobacco plants. Do not spray in
the bud stage of the tobacco plants, as crop
injury may occur. If weeds begin to emerge, a
shallow cultivation of 1 to 2 inches is recom-
mended.
Issued: 1-17-84
1-104201-13
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Tolerance, Use, Limitations
Site, Dosage
and Formulation
(Ib a.i./A)
(Ornamental Plants and Forest Trees)
/31303AA African Trailing Daisy
/34427AA Akeake
/34148AA Algerian Ivy
/35288AA American Holly
(HowardT
/35288DA American Holly
(Howard) (nursery
stock)
/34487AA Amur Privet
/34487DA Amur Privet (nursery
stock)'
/35315AA Andorra Juniper
/34543AA Argentine Trumpet-
vine
/34543DA Argentine Trumpet-
vine (nursery stock)
/34297AA Azalea (Gable Hy-
brids)
/34297DA Azalea (Gable Hy-
brids) (nursery
stock)
/34545AA Azalea (Louisa)
/34545DA Azalea (Louisa)
(nursery stock)
/31034AA Begonia
/33086AA Big Blue Lilyturf
(Ground CovefJ
/33086DA Big Blue Ulyturf
(Ground CoverT
(nursery stock)
/34451AA Bigleaf Wintercreeper
/34451DA Bigleaf Win'cercreeper
(nursery stock"!
/31038AA Bird-of-Paradise
/35033AA Blue Spruce
/35033DA Blue Spruce (nursery
stock)
/34346AA Border Forsythia
/34031AA Boxwood
/34031DA Boxwood (nursery
stock)
/3442LAA Bright Bead Coton-
easter
/35378AA Brush Cherry
/35378DA Brush Cherry (nursery
stock)
Issued: 1-17-84
1-104201-14
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Site, Dosage
and Formulation
(Ib a.i./A)
Tolerance, Use, Limitations
African Trailing Daisy cluster (continued)
/35386AA California-Laurel
/35385AA Canary Pine
/35385DA Canary Pine (nursery
stock)
/34L57AA Cape-Jasmine
/34157DA Cape-Jasmine (nursery
stock)
/35384AA Carolina Cherry-
Laurel
/34158AA Ceanothus
/34158DA Ceanothus (nursery
stock)
/34040AA Cherry Laurel
/34417AA Chinese Firethorn
/34417DA Chinese Firethorn
(nursery stock7~
/34160AA Chinese Hibiscus
/34161AA Chinese Holly
/34161DA Chinese Holly (nursery
stock)
/35155AA Chinese Juniper
/35155DA Chinese Juniper
(nursery stock)
/34419AA Chinese Star-Jasaine
734486AA Coast Leucothoe
/34486DA Coast Leucothoe
(nursery stock)
/31493AA Common Geranium
/31496AA Common Zinnia
/34305AA Convex Leaf Holly
/34305DA Convex Leaf Holly
(nursery stock)
/34560AA Cotoneaster Parneyi
/34560DA Cotoneaster Parneyi
(nursery stock)
/34244AA Cranberry Cotoneaster
/34244DA Cranberry Cotoneaster
(nursery stock)
/34046AA Crape Myrtle
/34046DA Crape Myrtle (nursery
stock)
/35160AA Creeping Juniper
/35160DA Creeping Juniper
(nursery stock)
/35236AA Cryptomeria
/35236DA Cryptomeria (nursery
stock)
Issued: 1-17-84
1-104201-15
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Site, Dosage
and Formulation
(Ib a.i./A)
Tolerance, Use, Limitations
African Trailing Daisy cluster (continued)
/33130AA Dwarf Coyotebrush
/31237AA Easter Cactus
/31237DA Easter Cactus
(nursery sto'ck)
/35047AA Eastern Redcedar
/35047DA Eastern Redcedar
(nursery stock)
/35048AA Eastern White Pine
/35237AA Ellwood False Cypress
/35237DA Ellwood False Cypress
(nursery stock)
/34323AA Emerald Cushion
Euonymus
/34323DA Emerald Cushion
Euonymus (nursery
stock)
/35169AA English Holly
/34052AA English Ivy
/34561AA Escallonia (Trades)
/34561DA Escallonia (Frades)
(nursery stock)
/35297AA Eucalyptus cinerea
/34233AA Evergreen Euonymus
/34233DA Evergreen Euonymus
(nursery stock)
/34172AA Fatshedera
/34172DA Fatshedera (nursery
stock)'
/34056AA Fetter-Bush
/34056DA Fetter-Bush (nursery
stock)'
/34237AA Floribunda Rose
/34237DA Floribunda Rose
(nursery stock)
/31491AA Florists' Chrysanthe-
mum
/34176AA Formosan Pyracantha
/34176DA Formosan Pyracantha
(nursery stock)
/34518AA Fraser Photinia
/34518DA Fraser Photinia
(nursery stock)
/31239AA French Marigold
/31494AA Garden Petunia
/35062AA Ginkgo
/35062DA Ginkgo (nursery
stock)
Issued: 1-17-84
1-104201-16
-------
/34422AA
/34179AA
/34179DA
/35063AA
/33104AA
/35403AA
/35403DA
/34331AA
/34331DA
/34313AA
/34313DA
/34071AA
/34233AA
/34238DA
/34075AA
/34075DA
/35340AA
/35340DA
/35182AA
/35182DA
/34078AA
/34078DA
/34079AA
/34079DA
/35185AA
/35185DA
/34272AA
/34272DA
/33119AA
Site, Dosage
and Formulation
(Ib a.i./A)
EPA Index to Pesticide Chemicals
ORYZALIN
Tolerance, Use, Limitations
African Trailing Daisy cluster (continued)
Glossy Abelia
Glossy Privet
Glossy Privet (nursery
stock)
Golden-Rain Tree
Greater Periwinkle
(Ground Cover)
Greek Juniper
Greek Juniper
(nursery stock)
Greek Myrtle
Greek Myrtle (viursery
stock)
Hiryu Azalea
(Hinodegiri)
Hiryu Azalea
(Hinodegiri)
(nursery stock)
Holly osmanthus
Hybrid Tea Roses
Hybrid Tea Roses
(nursery stockT
India Hawthorn
India Hawthorn
(nursery sto'ck)
Interior Live Oak
Interior Live Oak
(nursery stock)
Italian Cypress
Italian Cypress
(nursery stock)
Japanese Andromeda
Japanese Andromeda
(nursery stock)
Japanese Barberry
Japanese Barberry
(nursery stock)
Japanese Black Pine
Japanese Black Pine
(nursery stock)
Japanese Boxwood
Japanese Boxwood
(nursery stock)
Japanese Garden Juni-
per (Ground Cover)
Issued: 1-17-84
1-104201-17
-------
/33119DA
/34307AA
/34310AA
/34310DA
/34188AA
/34188DA
/35072AA
/34285AA
/34285DA
/34414AA
/34414DA
/33103AA
/34089AA
/34089DA
/31411AA
/31411DA
/34504AA
/34504DA
/34091AA
/34097AA
/35289AA
/341UOAA
/34100DA
/35328AA
/35328DA
/34562AA
/34102AA
/34102DA
/34103AA
/35254AA
Site, Dosage
and Formulation
(Ib a.i./A)
EPA Index Co Pesticide Chemicals
ORYZALLN
Tolerance, Use, Limitations
African Trailing Daisy cluster (continued)
Japanese Garden Juni-
per (Ground Coyer)
(nursery stock)
Japanese Honeysuckle
Japanese Pittosporum
Japanese Pittosporum
(nursery stock)
Japanese Privet
Japanese Privet
(nursery stock)
Japanese Yew
Laurustinus
Laurustitms (nursery
stock)
Lemon Bottlebrush
Lemon Bottlebrush
(nursery stock)
Lesser Periwinkle
(Ground Covet)
Lilac
Lilac (nursery stock)
Lily-of-the-Nile
Lily-of-the-Nile
(nursery stockT
Lowfast Bearberry
Cotoneaster
Lowfast Bearberry
Cotoneaster (nursery
stock)
Manzanita
Mountain-Laurel
Myoporum
Nandina
Nandina (nursery
stock)
Narrow Leaved Black
Peppermint
Narrow Leaved Black
Peppermint (nursery
stock)
Old-fashioned Weigela
Oleander
Oleander (nursery
stock)
Oregongrape
Oriental Arborvitae
Issued: 1-17-84
1-104201-18
-------
Site, Dosage
and Formulation
(Ib a.i./A)
EPA Index to Pesticide Chemicals
ORYZALIN
Tolerance, Use, Limitations
/35254DA
/31149AA
733117AA
/33117DA
/34353AA
/35380AA
/34492AA
/34492DA
/34555AA
/34555DA
/34493AA
/34493DA
/34205AA
/34205DA
/35354AA
/35354DA
/35491AA
/35491DA
/34120AA
/34208AA
/34208DA
/34122AA
/35205AA
/35205DA
/34295AA
African Trailing Daisy cluster (continued)
Oriental Arborvitae
(nursery stock)
Pansies
Purpleleaf Winter-
creeper
Purpleleaf Winter-
creeper (nursery
stock)
Pyrenees Cotoneaster
Red Ironbark Eucalyp-
tus
Rhododendron (PJM
Hybrids)
Rhododendron (PJM
Hybrids) (nursery
stock)
Rhododendron
(Ponticum Hybrids)
Rhododendron
(Ponticum Hybrids)
(nursery stock)'
Rhododendron (Rose-
bud)
Rhododendron (Rose-
bud) (nursery stock)
Rockspray Cotoneaster
Rockspray Cotoneaster
(nursery stockT
Rocky Mountain Juni-
Rocky Mountain Juni-
per (nursery stock)
Rocky Mountain Sugar
Maple
Rocky Mountain Sugar
Maple (nursery
stock)
Rose
Sakaki
Sakaki (nursery
stock)
Sandankwa Viburnum
Savin Juniper
Savin Juniper
(nursery stock)
Scarlet Firethorn
Issued: 1-17-84
1-104201-19
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Site, Dosage
and Formulation
(Ib a.i./A)
Tolerance, Use, Limitations
African Trailing Daisy cluster (continued)
/34295DA Scarlet Fire thorn
(nursery stock)
/34420AA Shiny Xylosoma
/35209AA Shore Juniper
/35209DA Shore Juniper
(nursery stock)
/31420AA Shortleaf Stonecrop
/31408AA Shrimp Plant
/31408DA Shrimp Plant (nursery
stock)
/35388AA Soap Tree
/35388DA Soap Tree (nursery
stock)'
/35216AA Southern Magnolia
/33126AA St. John's-Wort
(Ground Cover)
/35118AA Sweetgum
/35118DA Sweetgum (nursery
stock)'
/35393AA Swiss Mountain Pine
/35393DA Swiss Mountain Pine
(nursery stock)
/31455AA Treasure Flower
/34309AA Vicary Golden Privet
/34309DA Vicary Golden Privet
(nursery stock)
/35123AA Western Redcedar
/35123DA Western Redcedar
(nursery stock!
/35137AA Wilson Chinese Juni-
per
/35137DA Wilson Chinese Juni-
per (nursery stockT
/34232AA Winged Euonymus
/34388AA Yaupon
/34388DA Yaupon (nursery
stock)
/35253AA Yew Podocarpus
/35253DA Yew Podocarpus
(nursery stock)
/31492AA Zanzibar Balsam
Issued: 1-17-84
1-104201-20
-------
EPA. Index to Pesticide Chemicals
ORYZALIN
Site, Dosage Tolerance, Use, Limitations
and Formulation
Clb a.i./A)
African Trailing Daisy cluster (continued)
General Information; Apply only to established
plantings. Rooted liners should be established
in containers 2 weeks prior to treatment or crop
injury may occur. On container grown ornamentals
where weed germination continues for extended
periods of time, repeat applications may be made
after 90 days. Do not apply in ornamental plant-
ings where the likelihood of runoff onto lawn
areas containing dichondra or cool season turf-
grasses exists, as severe injury or death may
occur. Do not plant any ornamental species not
listed into soil treated the previous season or
injury may occur.
2-4 Broadcast application for short and long term
(75% WP) weed control. Apply as a directed or over-the-top
(4 Ib/gal F1C) spray. Use the higher dosage when long term (6
to 8 months) control is desired.
2-4 Directed spray to undesirable vegetation. Use
(75% WP) the higher dosage when long term (6 to 8 months)
(4 Ib/gal FIG) weed control is desired.
Tank mix with glyphosate, isopropylamine salt.
Issued: 1-17-84 1-104201-21
-------
EPA Index to Pesticide Chemicals
ORYZALIN
/33107AA
/31996AA
/67U040A
/b70060A
Site, Dosage
and Formulation
(Ib a.i./A)
Largeleaf Iceplant
(ground cover)
White Iceplant
Tolerance, Use, Limitations
2-4
(75% WP)
(4 Ib/gal F1C)
2-4
(75% WP)
(4 Ib/gal
F1C)
General Information; When establishing unrooted
iceplanc on coarse soils in landscape plantings,
use only the 2 Ib a.i./A dosage. After the ice-
plant is well established, a second application
may be made. Apply only to established plantings.
Rooted liners should be established in containers
2 weeks prior to treatment or crop injury may
occur. On container grown ornamentals where weed
germination continues for extended periods of
time, repeat applications may be made after 90
days. Do not apply in ornamental plantings where
the likelihood of runoff onto lawn areas contain-
ing dichondra or cool season turfgrasses exists,
as severe injury or death may occur. Do not plant
any ornamental species not listed into soil
treated the previous season or injury may occur.
Broadcast application for short and long term
weed control. Apply as a directed or over-the-top
spray. Use Che higher dosage when long term (6
to 8 months) control is desired.
Directed spray to undesirable vegetation. Use
the higher dosage when long term (6 to 8 months)
weed control is desired.
Tank mix with glyphosate, isopropylamine salt.
(Noncrop, Wide Area> and General Outdoor Treatments)
Highway Rights-of-Way
Utility Rights-of-Way
2-4
(75% WP)
(4 Ib/gal F1C)
General Information; Use for control of weeds in
or around utility substations, highway guardrails,
sign posts and delineators and similar sites.
Broadcast. Apply to weed foliage. Use the higher
dosage for long term weed control.
May be tank mixed with MSMA; dalapon; paraquat
dichloride; or glyphosate, isopropylamine salt.
Issued: 1-17-84
1-104201-22
-------
Site, Dosage
and Formulation
Clb a.i./A)
EPA Index to Pesticide Chemicals
ORYZALIN
Tolerance, Use, Limitations
GREENHOUSE NON-FOOD CROP
(Ornamental Plants and Forest Trees)
/40005CA Greenhouse Benches
0.75-1.5 oz a.i./
1,000 sq.ft
(75* WP)
(4 Ib/gal F1C)
0.75-1.5 oz a.i./
1,000 sq.ft
(75% WP)
(4 Ib/gal F1C)
Directed spray. Apply to drainage areas under
greenhouse benches. Use the higher dosage for
long term weed control.
Directed spray to emerged weeds. Use the higher
dosage for long term weed control.
Tank mix with MSMA; dalapon; paraquat dichloride;
or glyphosate, isopropylamine salt.
FORESTRY
/30153AA Alpine Fir
/3U084AA Austrian Pine
/30128AA Balsam Fir
/30111AA Bishop Pine
/30107AA Black Spruce
/30141AA Blue Spruce
/30005AA Christmas Tree Plan-
tations
/30L52AA Coulter Pine
/300o9AA Douglas-Fir
/30100AA Eastern White Pine
/30093AA Englemann Spruce
/30129AA Fraser Fir
/30090AA Grand Fir
/30112AA Monterey Pine
/30130AA Norway Spruce
/30062AA Redwood
/30113AA Scotch Pine
/30154AA Veitch Fir
/30092AA White Fir
/3010aAA White Spruce
2-4
(75* WP)
(4 Ib/gal F1C)
Broadcast application for short or long term weed
control. Apply as a directed or over-the-top
spray. Use the higher dosage for long term (6 to
8 months) control.
Tank mix with simazine.
Issued: 1-17-84
1-104201-23
-------
Site, Dosage
and Formulation
(Ib a.i./A)
AERIAL AM) TANK MIX APPLICATIONS
EPA Index to Pesticide Chemicals
ORYZALIN
Tolerance, Use, Limitations
9001500
AAAAAAA
Aerial Application
9900300
AAAAAAA
Tank Kix
Refer to
TERRESTRIAL FOOD CROP
(Agricultural Crops)
Cotton, Soybeans
Refer to
TERRESTRIAL FOOD CROP
(Agricultural Crops)
All sites except Cotton, Currant, Elderberry,
Kiwi Fruit, Pomegranate
GREENHOUSE NON-FOOD CROP
(Ornamental Plants and"Forest Trees)
Greenhouse Benches
TERRESTRIAL NON-FOOD CROP
(Ornamental Plants and Forest Trees)
All sites
(Non-crop, Wide Area, and General Outdoor
treatments)
All sites
FORESTRY
All sites
Issued: 1-17-84
1-104201-24
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Listing of Registered Pesticide Products by Formulation
&075.0006 757. wettable powder
oryzalin (104201)
001471-00096 001471-00102
&101.5012 1.5 Ib/gal emulsifiable concentrate
oryzalin (104201) plus trifluralin
(036101)
001471-00137
&102.0012 2 Ib/gal emulsifiable concentrate
oryzalin (104201)
001471-00105
&104.0014 4 Ib/gal flowable concentrate
oryzalin (104201)
001471-00112 001471-00113
9999999 State Label Registrations
Al Reg. No.
001471-06080 001471-06107
CA Reg. No.
001471-06110 001471-06194
FL Reg. No.
001471-06108
GA Reg. No.
001471-06077
IN Reg. No.
001471-06104
KS Reg. No.
001471-06105
KY Reg. No.
001471-06106
MI Reg. No.
001471-06076
NC Reg. No.
001471-06253
OH Reg. No.
001471-06230
Issued: 1-17-84
1-104201-25
-------
EPA Index to Pesticide Chemicals
ORYZALIN
State Label Registrations (continued)
OK Reg. No.
001471-06078
TN Reg. No.
001471-06254
VA Reg. No.
001471-06079
Issued: 1-17-84 1-104201-26
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix A
Listing of Common Chemical Names Used on the Entry
Chemical Common Name EPA Acceptable
Code (source) Common/Chemical Name
013803 • MSMA monosodium acid methanearsonate
030702 naptalam N-1-naphthylphthalamic acid
Issued: 1-17-84 1-104201-27
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No.
BROADLEAF WEEDS CONTROLLED;
PBFDCBC Annual sowthistle
PBKAIAA Bittercress
PBKAFBF Black mustard
PEWAIBE Black nightshade
PADABBA Carpetweed
PAZAAAC Chickweed
PAMAIBA Climbing milkweed
PARABBB Coast fiddleneck
PAZAOBB Common chickweed
PBFCXBK Common groundsel
PBDAEBA Common lambsquarters
PDAAHBB Common mallow
PEDADBA Common purslane
PBFAEBA Coomon ragweed
PDPABBA Creeping woodsorrel
PEMAEBB Florida pusley
PBFAEBE Giant ragweed '
PCOAFBA Henbit
PBFAVBA Horseweed
PEAAGBP Ladysthumb
PBDAEAB Lambsquarters
PBKBDBB London rocket
PEMAEAA Mexican clover
PBGAAAB Morningglory
PEAAGBO Pennsylvania smartweed
PAAAABI Pigweed
PBFCEBF Prickly lettuce
PDAAJBF Prickly slda
PEAAGBD Prostrate knotweed
PAFACBC Prostrate pigweed
PBVAGBQ Prostrate spurge
PFMAFBB Puncturevine
PAAAABP Purslane
PEDABBA Redmaids rockpurslane
PAFACBI Redroot pigweed
PBZABBB Redstem filaree
PEDABAA Rockpurslane
PAFACAB Rough pigveed
PBKAHBA Shepherdspurse
PEAAGAD Smartweed
PAFACBE Smooth pigweed
PAFACBJ Spiny amaranth
PBVAGBK Spotted spurge
PAFACBA Tumble pigweed
PDAABBB Velvetleaf
PBZABBC Whitestem filaree
PBKAFBE Wild mustard
Issued: 1-17-84
1-104201-28
-------
PCACKBA
PCABHBB
PCACEBE
PCAAUBA
PCABFAA
PCABCBA
PCABLAA
PCACEBD
PCAAWBB
PCACUAA
PCACUBA
PCABIBA
PCACUBF
PCABZBA
PCACWBG
-PCABHBA
PCABFBF
PCABSBF
PCABKBE
PCABKBK
PCABYBB
PCACCBA
PCACUAC
PCAARAA
PCABFBD
PCABLBA
PCACEBL
PCADFBA
PCAAOBB
PAAAABC
PCACEBC
PCACUBD
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
GRASSES AND OTHER MONOCQTS CONTROLLED;
Annual bluegrass
Barnyardgrass
Browntop panicum
Buffalograss
Crabgrass
Crowfootgrass
Cupgrass
Fall panicum
Field sandbur
Foxtail
Giant foxtail
Goosegrass
Green foxtail
Italian ryegrass
Johnsongrass (seedling)
Junglerice
Large crabgrass
Little barley
Mexican lovegrass
Orcutt lovegrass
Red sprangletop
Rice
Robust foxtail
Signalgrass
Smooth crabgrass
Southwestern cupgrass
Texas panicum
Wheat (volunteer)
Wild oat
Wiregrass
Witchgrass
Yellow foxtail
TERRESTRIAL FOOD CROP
(Agricultural Crops)
/03001AA Almond
Pests (see above)
(75% WP)
001471-00096
(2 Ib/gal EC)
001471-00105
Issued: 1-17-84
1-104201-29
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
Almond (continued)
(4 Ib/gal FIG)
001471-00112
/04001AA Apple
Pests (see above)
(75% WP)
001471-00096
(2 Ib/gal EC)
001471-00105
(4 Ib/gal F1C)
001471-00112
/04001DA Apple (nursery stock)
Pests(see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/05001AA Apricot
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/06001AA Avocado
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/04003DA Bartlett Pear (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-64
1-104201-30
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/01002AA Blackberry
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/01009AA Blueberry
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/01003AA Boysenberry
Pests (see above)
(4 Ib/gal F1C)
001471-00112
/05002DA Cherry (nursery stock)
Pests(see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/'J5002AA Cherry (Sour, Sweet)
Pests (see above)
(75% WP)
001471-00096
(2 Ib/gal EC)
001471-00105
(4 Ib/gal F1C)
001471-00112
/28007AA Cotton
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
Issued: 1-17-84
1-104201-31
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/01011AA Currant
Pests (see above)
(4 Ib/gal F1C)
001471-00112
/01004AA Dewberry
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/01012AA Elderberry
PestsTsee above)
(4 Ib/gal F1C)
001471-00112
/03009AA English Walnut
Pests(see above)
(75% WP)
001471-00096
(2 Ib/gal EC)
001471-00105
(4 Ib/gal F1C)
001471-00112
/06005AA Fig
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/03005AA Filbert
Pests (see above)
(75% WP)
001471-00096
(4 lh/gal F1C)
001471-00112
/01013AA Gooseberry
Pests (see above)
(4 Ib/gal F1C)
001471-00112
Issued: 1-17-84
1-104201-32
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/0101AAA Grapes
Pests (see above)
(75% WP)
001471-00096
(2 Ib/gal EC)
001471-00105
(4 Ib/gal F1C)
001471-00112
/02002AA Grapefruit
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/06018AA Kiwi Fruit
Pests £s~ee above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/02004AA Lemon
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/01005AA Loganberry
Pests (see above)
(4 Ib/gal F1C)
001471-00112
/03007AA Macadamia Nut
Pests (see above)
(4 Ib/gal F1C)
001471-00112
/28012AA Mint (Peppermint, Spearmint)
Pests (see above)
(75% WP)
001471-00096
Issued: 1-17-84
1-104201-33
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
Mint (Peppermint, Spearmint) (continued)
(4 Ib/gal F1C)
001471-00112
/05003AA Nectarine
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/06009AA Olive
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/02006AA Orange
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal FIG)
001471-00112
/05004AA Peach
Pests (see above)
(75% WP)
001471-00096
(2 Ib/gal EC)
001471-00105
(4 Ib/gal F1C)
001471-00112
/04003AA Pear
Pests (see above)
(75% WP)
001471-00096
(2 Ib/gal EC)
001471-00105
Issued: 1-17-84
1-104201-34
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
Pear (continued)
(4 Ib/gal F1C)
001471-00112
/28016AA Peas (English, Green)
Pests (see above)
(4 Ib/gal F1C)
001471-00112
/03008AA Pecan
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/03011AA Pistachio
Pests (see above)
(75% WP)
001471-00096
(2 Ib/gal EC)
001471-00105
(4 Ib/gal F1C)
001471-00112
/05005AA Plum
Pests (see above)
(75% WP)
001471-00096
(2 Ib/gal EC)
001471-00105
(4 Ib/gal F1C)
001471-00112
/06015AA Pomegranate
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
Issued: 1-17-84
1-104201-35
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/14013AA Potato (White)
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/05006AA Prune
Pests (see above)
(75% WP)
001471-00096
(2 Ib/gal EC)
001471-00105
(4 Ib/gal F1C)
001471-00112
/01006AA Raspberry
Pests (see above)
(75% WP)
001471-00096
(4 Ib/gal F1C)
001471-00112
/28023AA Soybeans
Pests (see above)
(75% WP)
001471-00096
(1.5 Ib/gal EC)
001471-00137
(2 Ib/gal EC)
001471-00105
(4 Ib/gal F1C)
001471-00112
Issued: 1-17-84
1-104201-36
-------
/26005AA
/26006AA
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
TERRESTRIAL NON-FOOD CROP
(Agricultural Crops)
Tobacco, Air Cured (Burley, Maryland, Dark)
Pests (see above)
(4 Ib/gal F1C)
001471-00112
Tobacco, Flue Cured
Pests (see above)
(4 Ib/gal F1C)
001471-00112
GREENHOUSE NON-FOOD CROP
(Ornamental Plants and Forest Trees)
/40005CA Greenhouse Benches
Pests(see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
TERRESTRIAL NON-FOOD CROP
(Ornamental Plants and Forest Trees)
/31303AA African Trailing Daisy
Pests (see above)
(757= WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34427AA Akeake
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-37
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34148AA Algerian Ivy
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/35288AA American Holly (Howard)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35288DA American Holly (Howard) (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34487AA Amur Privet
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34487DA Amur Privet (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/35315AA Andorra Juniper
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-38
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34543AA Argentine Trumpetvine
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34543DA Argentine Trumpetvine (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/34297AA Azalea (Gable Hybrids)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/34297DA Azalea (Gable Hybrids) (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471^30113
/34545AA Azalea (Louisa)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34545DA Azalea (Louisa) (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-39
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/31034AA Begonia
Pests (see above)
(75Z WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/33086AA Big Blue Lilyturf (Ground Cover)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/33G86DA Big Blue Lilyturf (Ground Cover) (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34451AA Bigleaf Wintercreeper
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34451DA Bigleaf Wintercreeper (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/31038AA Btrd-of-Paradise
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-40
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/35033AA Blue Spruce
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/35033DA Blue Spruce (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/34346AA Border Forsythla
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/3403LAA Boxwood
Pests (see -above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34031DA Boxwood (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34421AA Bright Bead Cotoneaster
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-41
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/35378AA Brush Cherry
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35378DA Brush Cherry (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35386AA California-Laurel
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35385AA Canary Pine
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35385DA Canary Pine (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34157AA Cape-Jasmine
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-42
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34157DA Cape-Jasmine (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35384AA Carolina Cherry-Laurel
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34158AA Ceanothus
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/34L58DA Ceanothus (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34040AA Cherry Laurel
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34417AA Chinese Firethorn
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-43
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34417DA Chinese Firethorn (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34160AA Chinese Hibiscus
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34161AA Chinese Holly
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34161DA Chinese Holly (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35155AA Chinese Juniper
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35155DA Chinese Juniper (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-44
-------
EPA Index to Pesticide Chemicals
OR.YZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34419AA Chinese Star-Jasmine
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34486AA Coast Leucothoe
Pests (see above)
(752 WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34486DA Coast Leucothoe (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/31493AA Common Geranium
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/31496AA Common Zinnia
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34305AA Convex Leaf Holly
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-45
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34305DA Convex Leaf Holly (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34560AA Cotoneaster Parneyi
Pests(see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34560DA Cotoneaster Parneyi (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34244AA Cranberry Cotoneaster
Pests(see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34244DA Cranberry Cotoneaster (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34046AA Crape Myrtle
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-46
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34046DA Crape Myrtle (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C-)
001471-00113
/35160AA Creeping Juniper
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35160DA Creeping Juniper (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35236AA Cryptomeria
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35236DA Cryptomeria (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/33130AA Dwarf Coyotebrush
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-47
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/31237AA Easter Cactus
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/31237DA Easter Cactus (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35047AA Eastern Redcedar
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35047DA Eastern Redcedar (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35048AA Eastern White Pine
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35237AA Ellwood False Cypress
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-48
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/35237DA Ellwood False Cypress (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34323AA Eaerald Cushion Euouymus
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34323DA Emerald Cushion Euonymus (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35169AA English Holly
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34052AA English Ivy
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34561AA Escallonia (Frades)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-49
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34561DA Escallonia (Trades) (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35297AA Eucalyptus cinerea
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34233AA Evergreen Euonymus
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34233DA Evergreen Euonymus (nursery stock)'
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34172AA Fatshedera
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34172DA. Fatshedera (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-50
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34056AA Fetter-Bush
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34056DA Fetter-Bush (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34237AA Floribunda Rose
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34237DA Floribunda Rose (nursery stock)
Pests (see above)
(-75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/31491AA Florists' Chrysanthemum
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34176AA Formosan Pyracantha
Pests(see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-51
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34176DA Formosan Pyracantha (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34518AA Eraser Photinia
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34518DA Fraser Photinia (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FLO
001471-00113
/31239AA French Marigold
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/31494AA Garden Petunia
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/35062AA Glnkgo
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-52
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/35062DA Ginkgo (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34422AA Glossy Abelia
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34179AA Glossy Privet
Pests(see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/34179DA Glossy Privet (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35063AA Golden-Rain Tree
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/33104AA Greater Periwinkle (Ground Cover)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-53
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/35403AA Greek Juniper
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/35403DA Greek Juniper (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34331AA Greek Myrtle
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34331DA Greek Myrtle (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34313AA Hiryu Azalea (Hiaodegiri)
Pests(see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34313DA Hiryu Azalea (Hinodegiri) (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
Issued: 1-17-84
1-104201-54
-------
EPA Index to Pesticide Chemicala
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34071AA Holly Osmanthus
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34238AA Hybrid Tea Roses
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34238DA Hybrid Tea Roses (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34075AA India Hawthorn
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34075DA India Hawthorn (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35340AA Interior Live Oak
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-55
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Fonn/Reg. No. (continued)
/35340DA Interior Live Oak (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35182AA Italian Cypress
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35182DA Italian Cypress (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34078AA Japanese Androaeda
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34073DA Japanese Andromeda (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34079AA Japanese Barberry
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-56
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34079DA Japanese Barberry (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/35185AA Japanese Black Pine
Pests(see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35185DA Japanese Black Pine (nursery stock)
Pests(see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34272AA Japanese Boxwood
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34272DA Japanese Boxvood (nursery stock)
Pests(see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/33119AA Japanese Garden Juniper (Ground Cover)
Pests(see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-57
-------
EPA. Index to Pesticide Chemicals
ORYZAL1N
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/33119DA Japanese Garden Juniper (Ground Cover) (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34307AA Japanese Honeysuckle
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34310AA Japanese Pittosporum
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34310DA Japanese Pittosporuto (nursery stock)
Pests (see above)
(752 WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34188AA Japanese Privet
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34188DA Japanese Privet (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
Issued: 1-17-84
1-104201-58
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/35072AA Japanese Yew
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/33107AA Largeleaf Iceplant (ground cover)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34285AA Laurustinus
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/34285DA Laurustinus (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34414AA Lemon Bottlebrush
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34414DA Lemon Bottlebrush (nursery stock)
Pests (see above^5
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-59
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/33103AA Lesser Periwinkle (Ground Cover)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34089M Lilac
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/.34089DA Lilac (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/31411AA Lily-of-the-Nile
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/3141LDA Lily-of-the-Nile (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34504AA Lowfast Bearberry Cotoneaster
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-60
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34504DA Lowfast Bearberry Cotoneaster (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34091AA Manzanita
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34097AA Mountain-Laurel
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35289AA Myoporum
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/34100AA Nandina
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34100DA Nandina (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-61
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/35328AA Narrow Leaved Black Peppermint
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/35328DA Narrow.Leaved Black Peppermint (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
C01471-00113
/34562AA Old-fashioned Weigela
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34102AA Oleander
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34102DA Oleander (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34103AA Oregongrape
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued; 1-17-84
1-104201-62
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/35254AA Oriental Arborvitae
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35254DA Oriental Arborvitae (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/31149AA Pansies
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/33117AA Purpleleaf Wintercreeper
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/33117DA Purpleleaf Wintercreeper (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/3435JAA Pyrenees Cotoneaster
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-63
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/35380AA Red Ironbark Eucalyptus
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34492AA Rhododendron (PJM Hybrids)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/34492DA Rhododendron (PJM Hybrids) (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34555AA Rhododendron (Ponticum hybrids)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34555DA Rhododendron (Ponticum Hybrids) (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34493AA Rhododendron (Rosebud)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-64
-------
EPA Index to Pesticide Chemicals
OR.YZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34493DA Rhododendron (Rosebud) (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34205AA Rockspray Cotoneaster
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34205DA Rockspray Cotoneaster (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35354AA Rocky Mountain Juniper
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/35354DA Rocky Mountain Juniper (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/35491AA Rocky Mountain Sugar Maple
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-65
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/35491DA Rocky Mountain Sugar Maple (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34120AA Rose
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/34208AA Sakaki
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471^)0113
/34208DA Sakaki (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34122AA Sandankwa Viburnum
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35205AA Savin Juniper
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-66
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/35205DA Savin Juniper (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34295AA Scarlet Firethorn
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34295DA Scarlet Firethorn (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34420AA Shiny Xylosoma
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35209AA Shore Juniper
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35209DA Shore Juniper (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-67
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/31420AA Shortleaf Stonecrop
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/31408AA Shrimp Plant
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/31408DA Shrimp Plant (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35388AA Soap Tree
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/3538BDA Soap Tree (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/35216AA Southern Magnolia
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-68
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/33126AA St. John's-Wort (Ground Cover)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35118AA Sweetgum
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35118DA Sweetgum (nursery stock)
Pests (see above)
(75% WP)
U01471-00102
(4 Ib/gal F1C)
001471-00113
/35393AA Swiss Mountain Pine
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/33393DA Swiss Mountain Pine (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/31455AA Treasure Flower
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-69
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/34309AA Vicary Golden Privet
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34309DA Vicary Golden Privet (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/3:5123AA Western Redcedar
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35123DA Western Redcedar (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/31996AA White Iceplant
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
U01471-00113
/35137AA Wilson Chinese Juniper
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-70
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/35137DA Wilson Chinese Juniper (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34232AA Winged Euonymus
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/34388AA Yaupon
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/34388DA. Yaupon ^nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35253AA Yew Podocarpus
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/35253DA Yew Podocarpus (nursery stock)
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
Issued: 1-17-84
1-104201-71
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/31492AA Zanzibar Balsam
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
(Noncrop, Wide Area, and General Outdoor Treatments)
/670040A Highway Rlghts-of-Way
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/670060A Utility Rights-of-Way
Pests (see above)
(.75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
FORISTRY
/30153AA Alpine Fir
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30084AA Austrian Pine
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30128AA Balsam Fir
Pests (see above)
(75% WP)
001471-00102
Issued: 1-17-84
1-104201-72
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No, (continued)
Balsam Fir (continued)
(4 Ib/gal FIG)
001471-00113
/30111AA Bishop Pine
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30107AA Black Spruce
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30141AA Blue Spruce
Pests (see above)
(75% WP)
001471-OU102
(4 Ib/gal F1C)
001471-00113
/30005AA Christmas Tree Plantations
Pests tsee above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30152AA Coulter Pine
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-73
-------
EPA Index co Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued}
/30039AA Douglas-Fir
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30100M Eastern White Pine
Pests (see above)
(75Z WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30093AA Englemann Spruce
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/30129AA Fraser Fir
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal FIG)
001471-00113
/30090AA Grand Fir
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30112AA Monterey Pine
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-74
-------
EPA Index to Pesticide Chemicals
ORYZALIN
Appendix B
Listing by Site/Pest and Site/Form/Reg. No. (continued)
/30130AA Norway Spruce
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30062AA Redwood
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30113AA Scotch Pine
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30154AA Veitch Fir
Pes"s (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30092AA White Fir
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
/30108AA White Spruce
Pests (see above)
(75% WP)
001471-00102
(4 Ib/gal F1C)
001471-00113
Issued: 1-17-84
1-104201-75
-------
APPENDIX B
LABELING REQUIREMENTS
B-l - Submission of Revised Labeling
B-2 - UO CPR 16?. 10 Labeling Requirements
B-3 - Table of Labeling Requirements
3-4 - Physical/Chemical Hazards
Labeling Statement
121
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APPENDIX B-l
SUBMISSION OF REVISED LABELING
PIFRA requires each product to be labeled with accurate, complete
and sufficient instructions and precautions, reflecting the
results of data concerning the product and its ingredients.
Labeling requirements are set out in 40 CFR 162.10 (Appendix
B-2) and are summarized for products containing this active
ingredient in Appendix B-3• Applications submitted in response
to this Standard must include draft labeling for Agency review.
If revised labeling information complying with this Appendix and
the requirements described in Part II of the Standard, is not
submitted, EPA may issue a notice of intent to cancel the regis-
tration under FIFRA sec. 6(b)(l).
A. LABEL CONTENTS. 40 CFR 162.10 requires that certain specific
labeling statements appear at certain locations on the label.
This is referred to as format labeling. Specific label items
listed below are keyed to Appendix B-3.
Item 1. PRODUCT NAME - The name, brand or trademark is
required to be located on the front panel, preferably centered
in the upper part of the panel. The name of a product will
not be accepted if it is false or misleading.
Item 2. COMPANY NAME AND ADDRESS - The name and address of
the registrant or distributor is required on the label. The
name and address should be located at the bottom of the
front panel or at the end of the label text.
Item 3- NET CONTENTS - A net contents statement is required
on all labels or on the container of the pesticide. The
preferred location is the bottom of the front panel immediately
above the company name and address, or at the end of the
label text. The net contents must be expressed in the largest
suitable unit, e.g., "1 pound, 10 ounces" rather than "26
ounces." In addition to English units, net contents may be
expressed in metric units. [40 CFR I62.10(d)]
Item 4. EPA REGISTRATION NUMBER - The registration number
assigned to the pesticide product must appear on the label,
preceded by the phrase "EPA Registration No.," or "EPA Reg.
No." The registration number must be set in type of a size
and style similar to other print on that part of the label
on which it appears and must run parallel to it. The regis-
tration number and the required identifying phrase must not
appear in such a manner as to suggest or imply recommendation
or endorsement of the product by the Agency. [40 CFR I62.10(e)]
122
-------
Item 5. EPA ESTABLISHMENT NUMBER - The EPA establishment number,
preceded by the phrase "EPA Est." is the final establishment at
which the product was produced, and may appear in any suitable
location on the label or immediate container. It must also
appear on the wrapper or outside container of the package if the
EPA establishment number on the immediate container cannot be
clearly read through such wrapper or container. [40 CPR I62.10(f)]
Item 6A. INGREDIENTS STATEMENT - An ingredients statement is
required on the front panel. The ingredients statement must
contain the name and percentage by weight of each active ingredient
and the total percentage by weight of all Inert ingredients.
The preferred location is immediately below the product name.
The ingredients statement must run parallel with, and be clearly
distinguished from, other text on the panel. It must not be
placed in the body of other text. [40 CFR I62.10(g)]
Item 6B. POUNDS PER GALLON STATEMENT - For liquid agricultural
formulations, the pounds per gallon of active ingredient must be
indicated on the label.
Item 7. FRONT LABEL PRECAUTIONARY STATEMENTS - Front panel
precautionary statements must be grouped together, preferably
within a block outline. The table below shows the minimum type
size requirements for various size labels.
Size of Label .Signal Word "Keep Out of Reach
on Front Panel Minimum Type Size of Children"
in Square Inches All Capitals Minimum Type Size
6 point
6 point
R point
10 point
12 point
The statement "Keep
Out of Reach of Children" must be located on the front panel
above the signal word except where contact with children during
distribution or use is unlikely. OO CFR 162 .10( h) (1) ( ii) ]
Item 7B. SIGNAL WORD - The signal word (DANGER, WARNING, or
CAUTION)is required on the front panel immediately below
the child hazard warning statement. [40 CFR 162.10 (h)(l)(i)]
Item 7C. SKULL & CROSSBONES AND WORD "POISON" - For products
assigned a toxicity Category I on the basis of oral, dermal,
or inhalation toxicity, the word "POISON" shall appear on the
label in red on a background of distinctly contrasting color and
the skull and crossbones shall appear in immediate proximity to
the word "POISON." [40 CFR 162.10(h)(1)(i) ]
123
5 and under
above 5 to 10
above 10 to 15
above 15 to 30
over 30
Item 7A. CHILD HAZARD
6 point
10 point
12 point
14 point
Ifl point
WARNING STATEMENT -
-------
Item 7D. STATEMENT OF PRACTICAL TREATMENT - A statement of
practical treatment (first aid or other) shall appear on the
label of pesticide products In toxlclty Categories I, II,
and III. [40 CPR 162 .10( h) (1) ( 111) ]
Item 7E. REFERRAL STATEMENT - The statement "See Side (or
Back)Panelfor Additional Precautionary Statements" is
required on the front panel for all products, unless all
required precautionary statements appear on the front panel.
[40 CPR I62.10(h)(l)(iii)]
Item 8. SIDE/BACK PANEL PRECAUTIONARY LABELING - The
precautionary statements listed below must appear together
on the label under the heading "PRECAUTIONARY STATEMENTS."
The preferred location Is at the top of the side or back
panel preceding the directions for use, and it is preferred
that these statements be surrounded by a block outline. Each
of the three hazard warning statements must be headed by the
appropriate hazard title. [40 CFR 162.10 (h)(2)]
Item 8A. HAZARD TO HUMANS AND DOMESTIC ANIMALS - Where a
hazard exists to humans or domestic animals, precautionary
statements are required indicating the particular hazard, the
route(s) of exposure and the precautions to be taken to avoid
accident, injury or damage. [40 CPR 162.10 (h)(2)(l)]
Item 8B. ENVIRONMENTAL HAZARD - Where a ha/.ard exists to
non-target organisms excluding humans and domestic animals,
precautionary statements are required stating the nature of
the hazard and the appropriate precautions to avoid potential
accident, Injury, or damage. [-40 CFR 162 .10( h) ( 2) (li) ]
Item 8C. PHYSICAL OR CHEMICAL HAZARD -
1. Flammability statement. Precautionary statements relating
to flammability of a product are required to appear on the
label if it meets the criteria in Appendix B-4. The require-
ment is based on the results of the flashpoint determinations
and flame extension tests required to be submitted for all
products. These statements are to be located in the side/back
panel precautionary statements section, preceded by the
heading "Physical/Chemical Hazards." Note that no signal
word is used in conjunction with the flammability statements.
2. Criteria for declaration of non-flammability. The following
criteria will be used to determine if a product is non-flammable
a. A "non-flammable gas" is a gas (or mix,ture of gases)
that will not ignite when a lighted match is placed
against the open cylinder valve.
-------
b. A "non-flammable liquid" is one having a flashpoint
greater than 350°P (177°C).
c. A "non-flammable aerosol" is one which meets the following
criteria:
i. The flame extension is zero inches;
ii. There is no flashback; and
iii. The flashpoint of the non-volatile liquid component
is greater than 350°F (177°C).
3- Declaration of non-flammability. Products which meet the
criteria for non-flammability specified above may bear the
notation "non-flammable" or "non-flammable (gas, liquid,
etc.)" on the label. It may appear as a substatement to the
ingredients statement, or on a back or side panel, but shall
not be highlighted or emphasized (as with an inordinately
large type size) in any way that may detract from precaution.
4. Other physical/chemical hazard statements. When chemistry
data demonstrate hazards of a physical or chemical nature
other than flammability, appropriate statements of hazard
will be prescribed. Such statements may address hazards of
explosivity, oxidizing or reducing capability, or mixing
with other substances to produce toxic fames.
Item 9A. RESTRICTED USE CLASSIFICATION - FIPRA sec. 3(d) provides
for the classification of products for restricted use. Such use
may be limited to certified applicators or persons under their
direct supervision or may be subject to other restrictions that
may be imposed by regulation. Based on its review of oryzalin,
the Agency has not classified products containing this active
ingredient for restricted use.
Item 9B - There is no Item 9B.
Item 9C. MISUSE STATEMENT - All products must bear the misuse
statement, "It is a violation of Federal law to use this product
In a manner inconsistent with its labeling." This statement
appears at the beginning of the directions for use, directly
beneath the heading of that section.
Item 10A. REENTRY STATEMENT - A reentry interval has not been
established by the Agency for this chemical.
Item 10B - There is no Item 10B.
Item IOC. STORAGE AND DISPOSAL BLOCK - All labels are required
to bear storage and disposal statements. These statements are
125
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developed for specific containers, sizes, and chemical
content. These instructions must be grouped and appear
under the heading "Storage and Disposal" in the directions
for use. This heading must be set in the same type
sizes as required for the child hazard warning. Part II
of the Standard contains the specific disposal statement
for oryzalin and Appendix C sets forth the appropriate
container disposal statements.
Item 10D. DIRECTIONS FOR USE - Directions for use must he
stated in terms which can be easily read and understood
by the average person likely to use or to supervise the
use of the pesticide. When followed, directions must be
adequate to protect the public from fraud and from personal
injury and to prevent unreasonable adverse effects on
the environment. [UO CPR 162.10]
B. COLLATERAL LABELING. Bulletins, leaflets, circulars,
brochures, data sheets, flyers, or other written or graphic
printed :natter which is referred to on the label or which
Is to accompany the product are termed collateral labeling.
Such labeling may not bear claims or representations that
differ in substance from those accepted in connection with
registration of the product. It should be made part of the
response to this Standard and submitted for review.
126
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Appendix 3-2
Chapter 1—Environmental Protection Agency
§162.10 Labeling requirements.
(a) General—(1) Contents of the label. Every pesticide
product shall bear a label containing the information specified by
the Act and the regulations in this Part. The contents of a
label must show clearly and prominently the following:
(i) The name, brand/ or trademark under which the product is
sold as prescribed in paragraph (b) of this section;
(ii) The name and address of the producer, registrant, or
person for whom produced as prescribed in paragraph (c) of this
section;
(iii) The net contents as prescribed in paragraph (d) of this
section;
(iv) The product registration number as prescribed in paragraph
(e) of this section;
(v) The producing establishment number as prescribed in para-
graph (f) of this section;
(vi) An ingredient statement as prescribed in paragraph (g) of
this section;
(vii) Warning or precautionary statements as prescribed in
paragraph (h) of this section;
(viii) The directions for use as prescribed in paragraph (i)
of this section; and
(ix) The use classification(s) as prescribed in paragraph (j)
of this section.
(2) Prominence and legibility. (i) All words, statements,
graphic representations, designs or other information required on
the labeling by the Act or the regulations in this part must be
clearly legible to a person with normal vision, and must be placed
with such conspicuousness (as compared with other words, state-
ments, designs, or graphic matter on the labeling) and expressed
in such terms as to render it likely to be read and understood
by the ordinary individual under customary conditions of purchase
and use.
(ii) All required label text must:
(A) Be set in 6-point or larger type;
(B) Appear on a clear contrasting background; and
(C) Not be obscured or crowded.
(3) Language to be used. All required label or labeling text
shall appear in the English language. However, the Agency may
require or the applicant may propose additional text in other
languages as is considered necessary to protect the public. When
additional text in another language is necessary, all labeling
requirements win be applied equally to both the English and
other-language versions of the labeling.
(4) Placement of Label—(i) General. The label shall appear
on or be securely attached to the immediate container of the
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pesticide product. For purposes of this Section, and the mis-
branding provisions of the Act, "securely attached" shall mean
that a label can reasonably be expected to remain affixed during
the foreseeable conditions and period of use. If the immediate
container is enclosed within a wrapper or outside container
through which the label cannot be clearly read, the label must
also be securely attached to such outside wrapper or container,
if it is a part of the package as customarily distributed or
sold.
(ii) Tank cars and other bulk containers—(A) Transportation.
While a pesticide product is in transit, the appropriate
provisions of 49 CFR Parts 170-189, concerning the transportation
of hazardous materials/ and specifically those provisions con-
cerning the labeling, marking and placarding of hazardous materials
and the vehicles carrying them, define the basic Federal require-
ments. In addition, when any registered pesticide product is
transported in a tank car, tank truck or other mobile or portable
bulk container, a copy of the accepted label must be attached to
the shipping papers, and left with the consignee at the time of
delivery.
(3) Storage. When pesticide products are stored in bulk
containers, whether mobile or stationary, which remain in the
custody of the user, a copy of the label of labeling, including
all appropriate directions for'use, shall be securely attached to
the container In the immediate vicinity of the discharge control
valve.
(5) False or misleading statements. Pursuant to section
2(cj)(l)(A) of the Act, a pescicide or a device declared subject
to the Act pursuant to § 162.15, is misbranded if its labeling is
false or misleading in any particular including both pesticidal
and non-pesticida1 claims. Examples of statements or representations
in the labeling which constitute misbranding include:
(i) A false or misleading statement concerning the composition
of the product;
(ii) A false or misleading statement concerning the effectiveness
of the product as a pesticide or device;
(iii) A false or misleading statement about the value of the
product for purposes other than as a pesticide or device;
(iv) A false or misleading comparison with other pesticides or
dev ices;
(v) Any statement directly or indirectly implying that the
pesticide or device is recommended or endorsed by any agency of
the Federal Government;
(vi) The name of a pesticide which contains two or more
principal active ingredients if the name suggests one or more but
not all such principal active ingredients even though the names
of the other ingredients are stated elsewhere in the labeling;
(vii) A true statement used in such a way as to give a false
or misleading impression to the purchaser;
(viii) Label disclaimers which negate or detract from labeling
statements reguired under the Act and these regulations;
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(ix) Claims as to the safety of the pesticide or its ingredients,
including statements such as "safe," "nonpoisonous," "noninjurious,"
"harmless" or "nontoxic to humans and pets" with or without such
a qualifying phrase as "when used as directed"; and
(x) Non-numerical and/or comparative statements on the safety
of the product, including but not limited to:
(A) "Contains all natural ingredients";
(B) "Among the least toxic chemicals known"
(C) "Pollution approved"
(6) Final printed labeling. (i) Except as provided in
paragraph (a)(6)(ii) of this section, final printed labeling must
be submitted and accepted prior to registration. However, final
printed labeling need not be submitted until draft label texts
have been provisional!/ accepted by the Agency.
(ii) Clearly legible reproductions or photo reductions will be
accepted for unusual labels such as those silk-screened directly
onto glass or metal containers or large bag or drum labels. Such
reproductions must be of microfilm reproduction quality.
(b) Name, brand, or trademark. (1) The name, brand, or
trademark under which the pesticide product is sold shall appear
on the front panel of the label.
(2) No name, brand, or trademark may appear on the label which:
(i) Is false or misleading, or
(ii) Has not been approved by the Administrator through
registration or supplemental registration as an additional name
pursuant -to § 152.6(b)(4).
(c) Name and address of producer, registrant, or person for
whom produced. An unqualified name and eccre^j given ^n the
label snail oe considered as the name and address of che producer.
If the registrant's name appears on the label and the registrant
is not the producer, or if the name of the person for whom the
pesticide was produced appears on the label, it must be qualified
by appropriate wording such as "Packed for ***," "Distributed by
***," or "Sold by ***" to show that the name is not that of the
producer.
(d) Net weight or measure of contents. (1) The net weight or
measure of content shall be exclusive of wrappers or other
materials and shall be the average content unless explicitly
stated as a minimum quantity.
(2) tf the pesticide is a liquid, the net content statement
shall be in terms of liquid measure at 68°F (20°C) and shall be
expressed in conventional American units of fluid ounces, pints,
quarts, and gallons.
(3) If the pesticide is solid or semisolid, viscous or
pressurized, or is a mixture of liquid and solid, the net content
statement shall be in terms of weight expressed as avoirdupois
pounds and ounces.
(4) In all cases, net content shall be stated in terms of the
largest suitable units, i.e., "1 pound 10 ounces" rather than
"26 ounces."
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(5) In addition to the required units specified, net content
may be expressed in metric units.
(6) Variation above minimum content or around an average is
permissible only to the extent that it represents deviation
unavoidable in good manufacturing practice. Variation below a
stated minimum is not permitted. In no case shall the average
content of the packages in a shipment fall below the stated
average content.
(e) Product registration number. The registration number
assigned to the pesticide product at the time of registration
shall appear on the label, preceded by the phrase "EPA Registration
No.," or the phrase "EPA Reg. No." The registration number shall
be set in type of a size and style similar to other print on that
part of the label on which it appears and shall run parallel to
it. The registration number and the required identifying phrase
shall not appear in such a manner as to suggest or imply
recommendation or endorsement of the product by the Agency.
(f) Producing establishments registration number. The producing
establishment registration number preceded by the phrase "EPA
Est."/ of the final establishment at which the product was produced
may appear in any suitable location on the label or immediate
container. Et must appear on the wrapper or outside container of
the package if the EPA establishment registration number on the
imr-.'Bii La te container cannot be clearly read through such wrapper
or container.
(g) Ingredient scatement—(1) General. The label of each
pesticide product must bear a statement which contains the name
and percentage by weight of each active ingredient, the total
percentage by weight on all inert: ingredients; and if the pesticide
contains arsenic in any form, a statement of the percentages of
total and water-soluble arsenic calculated as elemental arsenic.
The active ingredients must be designated by the terra "active
ingredients" and the inert ingredients by the term "inert
ingredients," or the singular forms of these terms when appropriate.
Both terms shall be in the same type size, be aligned to the same
margin and be equally prominent. The statement "Inert Ingredients,
none" is not required for pesticides which contain 100 percent
active ingredients. Unless the ingredient statement is a complete
analysis of the pesticide, the term "analysis" shall not be used
as a heading for the ingredient statement.
(2) Position of ingredient statement. (i) The ingredient
statement is normally required on the front panel of the label.
If there is an outside container or wrapper through which the
ingredient statement cannot be clearly read, the ingredient
statement must also appear on such outside container or wrapper.
If the size or form of the package makes it impracticable to place
the ingredient statement on the front panel of the label, permission
may be granted for the ingredient statement to appear elsewhere.
(ii) The text of the ingredient statement must run parallel
with other text on the panel on which it appears, and must be
clearly distinguishable from and must not be placed in the body
of other text.
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(3) Names to be used in ingredient statement. The name used
for each ingredient shall bethe accepted common name, if there
is one, followed by the chemical name. The common name may be
used alone only if it is well known. I £ no common name has been
established, the chemical name alone shall be used. In no case
will the use of a trademark or proprietary name be permitted unless
such name has been accepted as a common name by the Administrator
under the authority of Section 25(c)(6),
(4) Statements of percentages. The percentages of ingredients
shall be saated in terms of weight-to-weight. The sum of per-
centages of the active and the inert ingredients shall be 100.
Percentages shall not be expressed by a range of values such as
"22-25%." If the uses of the pesticide product are expressed as
weight of active ingredient per unit area, a statement of the
weight of active ingredient per unit volume of the pesticide
formulation shall also appear in the ingredient statement.
(5) Accuracy of stated percentages. The percentages given
shall be as precise as possible reflecting good manufacturing
practice. If there may be unavoidable variation between manu-
facturing batches, the value stated for each active ingredient
shall be the lowest percentage which may be present.
(6) Deterioration. Pesticides which change in chemical
composition significantly must meet the following labeling re-
cu i rements:
(i) In cases where it is determined that a pesticide formulation
changes chemical composition significantly, the product must bear
the following statement in a prominent position on the label: "Not
for sale or use after (date)."1
(Li) The product must meet all label claims up to the expiracion
time indicated on the label.
(7) Inert ingredients. The Administrator may require the name
of any inert ingredient{s) to be listed in the ingredient statement
if he determines that such ingredient(s ) may pose a hazard to man
or the environment.
in) Warnings and precautionary statements. Required warnings
and precautionary statements concerning the general areas of
toxicological hazard including hazard to children, environmental
hazard, and physical or chemical hazard fall into two groups; those
required on the front panel of the labeling and those which may
appear elsewhere. Specific requirements concerning content,
placement, type size, and prominence are given below.
(1) Required front panel statements. With the exception of the
child hazard warning statement, the text required on the front
panel of the label is determined by the Toxicity Category of the
pesticide. The category is assigned on the basis of the highest
hazard shown by any of the indicators in the table below:
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Hazard Indicators
Craf ID
50
Inhalation 1C
50
Derma 1 1.0
50
eye ef tects
Sk!n effects
'
i
I
Up to and
Incf yd Ing
50 mg/kg
Up to and
Includ log
.2 mg/1 tter
Up to and
Incfud Ing
200 mgAg
Corrosive;
cornea/ opacity
not ravers !b la
*lrhln 7 days
Corrosive
Tox'clty <
1 1
From 50 thru'
500 mg/kg
From .2 thro
2 mg/I Itar
From 200
thru 2000
Cornea 1 opacity
ravers Ib (e
nlfhln 7 days;
Irr I tar I on
persisting for
7 days
Severe Irritation
at 72 hours
rategorlss
111
From 500 thru
5000 mg/kg
From 2 thru
20 mg/( Iter
From 2.000 thru
20.000
No cornea 1 opacity;
Irritation
reversible
within 7 days
Moderate Irritation
at 72 nours
IV
Greater than
5000 rag/ kg
Greater than
20 mg/l Iter
Greater than
20 , 000 j
MO Irritation |
1
!
Mild or si Ight
Irritation at
72 nours
(i) Human hazard signal word.--(A) Toxicity Category I. All
pesticide produces meeting the criteria of Toxicity Category I
shall bear on the front panel the signal word "Danger." In
addition if the product was assigned to Toxicity Category I on
the basis of its oral, inhalation or
from skin and eye local effects) the
in red on a background of distinctly
skull and crossbones shall appear in
word "poison."
All pesticide products meeting the
II shall bear on the front panel
dermal toxicity (as distinct
word "Poison" shall appear
contrasting color and the
immediate proximity to the
(B) Toxicity Category II.
criteria of Toxicity Category
the signal word "Warning."
(C) Toxicity Category III.
criteria of Toxicity Category
the signal word "Caution."
(D) Toxicity Category IV.
criteria of Toxicity Category
the signal word "Caution."
All pesticide products meeting the
III shall bear on the front panel
All pesticide products meeting the
IV shall bear on the front panel
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(E) Use of signal words. Use of any signal word(s) associated
with a higher Toxicity Category is not permitted except when the
Agency determines that such labeling is necessary to prevent
unreasonable adverse effects on man or the environment. In no
case shall more than one human hazard signal word appear on the
front panel of & label.
(ii) Child hazard warning. Every pesticide product label shall
bear on the (front panel the "s tatement "keep out of reach of
children." Only in cases where the likelihood of contact with
children during distribution, marketing, storage or use is
demonstrated by the applicant to be extremely remote, or if the
nature of the pesticide is such that it is approved for use on
infants or small children, may the Administrator waive this
requirement.
( i i i ) Statement of practical treatment—(A) Toxic i tv
Category I. A statement of practical treatment (first aid or
other)shall appear on the front panel of the label of all
pesticides falling into Toxicity Category I on the basis of oral,
inhalation or dermal toxicity. The Agency may, however, permit
reasonable variations in the placement of the statement of
practical treatment is some reference such as "See statement of
practical treatment on back panel" appears on the front panel
near the word "Poison" and the skull and crossbones.
(B) Other toxicity categories. The statement of practical
treatment is not required on the front panel except as described
in paragraph (h)(1){iii)(A) of this section. The applicant may,
however, include such a front panel statement at his option.
Statements of practical treatment are, however, required elsewhere
on t'ne label in accord with paragraph (h)(2) on this section if
they do not appear on the front panel.
(iv) Placement and prominence. All the required front panel
warning statements shall be grouped together on the Label, and
•shall appear with sufficient prominence relative to other front
panel text and graphic material to make them unlikely to be over-
looked under customary conditions of purchase and use. The
following table shows the minimum type size requirements for the
front panel warning statements on various sizes of labels:
Points
Size of label front panel
in square inches
Above 10 to 15
Above 15 to 30 .
Over 30
Required
signal word,
all capitals
6
10
12
14
18
"Keep out
of reach of
Children"
6
6
8
10
12
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(2) Other required warnings and precautionary statements. The
warnings and precautionary statements as required below shall appear
together on the label under the general heading "Precautionary
Statements" and under appropriate subheadings on "Hazard to Humans
and Domestic Andmals," "Environmental Hazard" and "Physical or
Chemical Hazard."
(i) Hazard t!o humans and domestic animals. (A) Where a hazard
exists to humans or domestic animals, precautionary statements
are required indicating the particular hazard, the route(s) of
exposure and the precautions to be taken to avoid accident, injury
or damage. The precautionary paragraph shall be immediately
preceded by the appropriate hazard signal word.
(B) The following table depicts typical precautionary statements.
These statements must be modified or expanded to reflect specific
hazards.
Precautionary statements by toxic Ity category
Toxic I r-,
category
Oral, Inhalation, or dermal roxfclty
Skin and eve local affects
I . . .( Fatal (poisonous) if swal lowed (Inhaled or
j absorbed through skin). Do not braathe
j vapor [dust! or spray mist!. Oo not gat
| In dyes, on sxlrj, or on c/otft/ng {Front
| panel statement of practical treatment
Ired. I .
| Corrosive, causes aye and skin damage !or |
j skin irritation). Do not get In eyas, on }
, or on cloth 'ng. Wear goggfas or face |
and ruobar g/ovas when handling. f
Harmful or fatal If swallowed. |
(Aopropr'ate f'-sf aid statement
May be fatal if swallowed 1 Inhaled or j
absorbed through the skin I. Oo not breathe)
vapors (dust or spray mlstl. Oo not gat ln[
eyes, on skin, or on clothing. (Approprlate|
first aid statements required.!. j
Causes eye (and skin) Irritation. Oo not
get In eyes, on skin, or on clothing.
Harmful If swallowed. (Appropriate first
aid statement required.!.
IV
Harmful If swallowed I Inhaled or absorbed
through the sklnl. Avoid breathing vapors
Idust or spray mlstl. Avoid contact «ltfi
Skin (eyes or clothing!. [Appropriate
first aid statement required.!.
I Ho precautionary statements required.!.
Avoid contact with sk'n, eyes or clothing.
In case of contact Immediately flush
eyes or skin with planty of water. Get
medical attention If Irritation persists.
j (No precautionary statements required.!
(ii) Environmental hazards. Where a hazard exists to non-
target organisms excluding humans and domestic animals, precautionary
statements are required stating the nature of the hazard and the
appropriate precautions to avoid potential accident/ injury or
-------
damage. Examples of the hazard statements and the circumstances
under which they are required follow:
(A) If a pesticide intended for outdoor use contains an active
ingredient with a mammalian acute oral LD5Q of 100 or less, the
statement "This Pesticide is Toxic to wildlife" is required.
(3) If a pesticide intended for outdoor use contains an active
ingredient with a fish acute LC5Q of 1 Ppm or less, the statement
"This Pesticide is Toxic to Fish" is required.
(C) If a pesticide intended for outdoor use contains an active
ingredient with an avian acute oral LD5Q of 100 mg/kg or less, or
a subacute dietary LC5Q of 500 ppm or less, the statement "This
Pesticide is Toxic to Wildlife" is required.
(D) If either accident history or field studies demonstrate
that use of the pesticide may result in fatality to birds, fish
or mammals, the statement "This pesticide is extremely toxic to
wildlife (fish)" is required.
(E) For uses involving foliar application to agricultural
crops, forests, or shade trees, or for mosquito abatement
treatments, pesticides toxic to pollinating insects must bear
appropriate label cautions.
(F) For ail outdoor uses other than aquatic applications the
label must bear the caution "Keep out of lakes, ponds or streams.
Do not contaminate water by cleaning of equipment or disposal of
wastes."
(iii) Physical or chemical hazards. Warning statements on the
f lanunabil ity or explosive cnaracteristics of the pesticide are
ceauired as follows:
Flash joint I Required taxt
tA) PRESSURIZED CONTAINERS
I
-1asn point at or Delow 20*F; If tnere is a | Extremely flammable. Contents unaer oressure.
tlastioac* at .jny valve opening. f Keep away from fire, soarxs, ana reared
j surfaces. Oo not puncture or Incinerate
\ container. Exposure ro temperatures aoove
} 130*F may causa oursting.
Flasn point aDove 20*F ana not over 30*F or if [ Mammaole. Contents under pressure. Keep a«ay
the flame extension is more than 18 in. long [ from neat, sparks, and open flame. Oo not
at a distance of 6 In. from the flame. [ puncture or Incinerate container. Exposure to
| temperatures above 1 30*F may cause Oursting.
All other pressurized containers ....... .| Contents under pressure. Oo not use or store
| near neat or open flame. Oo not puncture or
j fnctnerate container. Exposure to tampera-
| tures above 13Q*F may cause bursting.
(8) NONPRESSURIZED CONTAINERS
j
At or below ZQ'f ...[ Extremely flammable. Keep away from fire,
j sparks, and heated surfaces.
Above 20*F and not over 80*F ...| Flammable. Keep away from neat and open flame.
Above 80*F and not over I50*F . I Oo not use or store near heat or open flame.
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(i) Directions for Us e— (1) General requirements—(i} Adequacy
and clarity of directions. Directions for use must be stated in
terms which can be easily read and understood by the average
person likely to use or to supervise the use of the pesticide.
When followed, directions must be adequate to protect the public
from fraud and from personal injury and to prevent unreasonable
adverse effects on the environment.
(ii) Placement of directions for use. Directions may appear
on any portion of the label provided that they are conspicuous
enough to be easily read by the user of the pesticide product.
Directions for use may appear on printed or graphic matter which
accompanies the pesticide provided that:
(A) If required by the Agency, such printed or graphic matter
is securely attached to each package of the pesticide, or placed
within the outside wrapper or bag;
(B) The label bears a reference to the directions for use in
accompanying leaflets or circulars, such as "See directions in
the enclosed circular." and
(C) The Administrator determines that it is not necessary for
such directions to appear on the label.
( i i i ) Exceptions to requirement for direction for use—(A)
Detailed directions for use may be omitted from labeling of
pesticides which are intended for use only by manufacturers of
products other than pesticide products in their regular manu-
facturing processes, provided that:
(_!) The label clearly shows that the product is intended for
use only in manufacturing processes and specifies the type(s) of
products involved.
(2} Adequate information such as technical data sheets or
bulletins, is available to the trade specifying the type of
product involved and its proper use in manufacturing processes;
(_3_> The product will not come into the hands of the general
public except after incorporation into finished products; and
(4_) The Administrator determines that such directions are not
necessary to prevent unreasonable adverse effects on man or the
-?nv i ronmen t.
(B) Detailed directions for use may be omitted from the labeling
of pesticide products for which sale is limited to physicians,
veterinarians, or druggists, provided that:
(JJ The label clearly states that the product is for use only
by physicians or veterinarians;
(2) The Administrator determines that such directions are not
necessary to prevent unreasonable adverse effects on man or the
environment; and
(_3.) The product is also a drug and regulated under the provisions
of the Federal Food, Drug and Cosmetic Act.
(C) Detailed directions for use may be omitted from the labeling
of pesticide products which are intended for use only by formulators
in preparing pesticides for sale to the public, provided that:
(I] There is information readily available to the formulators
on the composition, toxicity, methods of use, applicable restrictions
or limitations, and effectiveness of the product for pesticide
purposes;
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(_2) The label clearly states that the product is intended for
use only in manufacturing, formulating, mixing, or repacking for
use as a pesticide and specifies the type(s) of pesticide products
involved;
(_3) The product as finally manufactured, formulated, mixed, or
repackaged is registered; and
M) The Administrator determines that such directions are not
necessary to prevent unreasonable adverse effects on man or the
environment.
(2) Contents of Directions for Use. The directions for use
shall include the following, under the headings "Directions for
Use " :
(i) The statement of use classification as prescribed in
162.10(j) immediately under the heading "Directions for Use."
(ii) Immediately below the statement of use classification,
the statement "It is a violation of Federal law to use this
product in a manner inconsistent with its labeling."
(iii) The site(s) of application, as for example the crops,
animals, areas, or objects to be treated.
(LV) The target pest(s) associated with each site.
(v) The dosage rate associated with each site and pest.
('/i) The method of application, including instructions for
dilution, if required, and type(31 of application apparatus or
equipment requried.
(vii) The frequency and timing of applications necessary to
obtain effective results without causing unreasonable adverse
effects on the environment.
(viii) Specific limitations on reentry to areas where the
pesticide has been applied, meeting the requirements concerning
reentry provided by 40 CFR Part 170.
(ix) Specific directions concerning the storage and disposal
of the pesticide and its container, meeting the requirements of
40 CFR Part 165. These instructions shall be grouped and appear
under the heading "Storage and Disposal." This heading must be
set in type of the same minimum sizes as required for the child
hazard warning (See Table in § 162. 10(h){ I)( iv).)
(x) Any limitations or restrictions on use required to prevent
unreasonable adverse effects, such as:
(A) Required intervals between application and harvest of food
or feed crops.
(B) Rotational crop restrictions.
(C) Warnings as required against use on certain crops, animals,
objects, or in or adjacent to certain areas.
(D) [Reserved]
(E) For restricted use pesticides, a statement that the
pesticide may be applied under the direct supervision of a
certified applicator who is not physically present at the site of
application but nonetheless available to the person applying the
pesticide, unless the Agency has determined that the pesticide
may only be applied under the direct supervision of a certified
applicator who is physically present.
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(F) Other pertinent information which the Administrator
determines to be necessary for the protection of man and the
environment.
(j) Statement of Use Classification. By October 22, 1976, all
pesticide products must bear on their labels a statement of use
classification as described in paragraphs (j)(l) and (2) of this
section. Any pesticide product for which some uses are classified
for general use and others for restricted use shall be separately
labeled according to the labeling standards set forth in this
subsection, and shall be marketed as separate products with
different registration numbers, one bearing directions only for
general use(s) and the other bearing directions for restricted
use(s) except that, if a product has both restricted use(s) and
general use(s), both of these uses may appear on a product labeled
for restricted use. Such products shall be subject to the
provisions of § 162.10 ( j) ( 2} .
(1) General Use Classification. Pesticide products bearing
directions for use(s) classified general shall be labeled with
the exact words "General Classification" immediately below the
heading "Directions for Use." And reference to the general
classification that suggests or implies that the general utility
of the pesticide extends beyond those purposes and uses contained
in the Directions for Use will oe consid3red a false or misleading
ota^einent under che scatucory definitions of misbrand ing.
(2) Restricted Use Classification. Pesticide products bearing
direction for use(s) classified restricted shall bear statements
of restricted use classification on the front panel as described
below:
f i) Front panel statement of restricted use classification.
(A) At the top of the front panel of the label, set in type of
the same minimum sizes as required for human hazard signal words
(see table in § 162.10(h)(1)(iv)), and appearing with sufficient
prominence relative to other text and graphic material on the
front panel to make it unlikely to be overlooked under customary
conditions of purchase and use, the statement "Restricted Use
Pesticide" shall appear.
(3) Directly below this statement on the front panel, a summary
statement of the terms of restriction imposed as a precondition
to registration shall appear. If use is restricted to certified
applicators, the following statement is required: "For retail
sale to and use only by Certified Applicators or persons under
their direct supervision and only (for those uses covered by the
Certified Applicator's certification." If, however, other
regulatory restrictions are imposed, the Administrator will define
the appropriate wording for the terms of restriction by regulation,
(k) Advertising. [Reserved]
[40 FR 28268, July 3, 1975; 40 FR 32329, Aug. L , 1975; 40 FR
38571, Aug. 21, 1975, as amended at 43 FR 5786, Feb. 9, 1978]
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LABELING REQUIREMENTS OP THE PIFRA, AS AMENDED
ITEM
1
2
3
1|
5
6A
6B
7
7A
7B
LABEL ELEMFM1
Product name
Company name
and address
Net contents
F.PA Reg. No.
F.PA Est. No.
Ingredients
statement
Pounds/gallon
statement
Front panel
precautionary
statements
Keep Out of Reach
of Children
(Child hazard
warning)
Signal word
APPLICABILITY
OF REQUIREMENT
All products
All products
All products
All products
All products
All products
Liquid products
where dosage
given as Ibs.
ai/unit area
All products
All products
All products
PLACEMFM1 ON LABEL
REQUIRED
Front panel
None
None
None
None
Front panel
Front panel
Front panel
Front panel
Front panel
PREFERRED
Center Front
panel
Bottom front
panel or end
of label text
Bottom front
panel or end
of label text
Front panel
Front panel ,
immediately
before or
following
Reg . No .
Immediately
fol lowing
product name
Directly below
the main
ingredients
statement
Above signal
word
Immediately
below child
hazard
warning
COMMENTS
If registrant is not the producer, must
be qualified by "Packed for . . .,"
"Distributed by. . .," etc.
May be in metric units in addition to
U.S. units
Must be in similar type size and run
parallel to other type.
May appear on the container instead of
the label .
Text must run parallel with other text
on the panel .
All front panel precautionary statements
must be grouped together, preferably
blocked .
Note type size requirements.
Note type size requirements .
CD
X
-------
4=-
O
ITEM
7C
7D
7E
8
8A
8B
LABEL ELEMENT
Skull & cross-
bones and word
POISON (in red)
Statement of
practical
treatment
Referral
statement
Side/back panel
precautionary
statements
Hazards to
himans and
domestic
animals
Envirormental
hazards
APPLICABILITY
OP REQUIREMENT
All products
which are Cat-
egory I based
on oral , der-
mal , or inhala-
tion toxicity
All products
in Categories
I, II, and III
All products
where pre-
cautionary
labeling
appears on
other than
front panel .
All products
All products
in Categories
I, II, and II £
All products
PLACEMENT ON LABEL
REQUIRED
Front panel
Category I :
Front panel
unless refer-
ral statement
is used.
Others •
Grouped with
side panel
precautionary
statements .
Front panel
None
None
None
PREFERRED
Both in close
proximity to
signal word
Front panel
for all.
Top or side
of back panel
preceding
directions
for use
Same as above
Same as above
COMMENTS
Must be grouped under the headings in
8A, 8B, and 8C; preferably blocked.
Must be preceded by appropriate signal
word.
Environmental hazards Include bee
caution where applicable.
-------
ITEM
8C
9A
9C
10A
IOC
10D
LABEL ELEMENT
Physical or
chan leal
hazards
Restricted
block
Misuse
statement
Reentry
statement
Storage and
disposal block
Directions
for use
APPLICABILITY
OP REQUIREMENT
All pressurized
products, others
with Plash
points under
150°P
All restricted
products
All products
All
cholinesterase
inhibitors
All products
All products
PLACEMENT ON LABEL
REQUIRED
None
Top center
of front
panel
Immediately
following
heading of
directions
for use
In the
directions
for use
In the
directions
for use
None
PREFERRED
Same as above
Preferably
blocked
Immediately
after misuse
statement
Immediately
before
specific
directions
for use or
at the end of
directions
for use
None
COMMENTS
Includes a statement of the terms of
restriction. The words "RESTRICTED USE
PESTICIDE" must be same type size as
signal word.
Must be set apart and clearly distin-
guishable from from other directions
for use.
May be In metric as well as U.S. units
-------
Appendix B-U
PHYSICAL-CHEMICAL HAZARDS
Criteria
I. Pressurized Containers
A.
Flashpoint at or below
20°P; or if there is a
flashback at any valve
opening.
Flashpoint above 20°F
and not over 80°F; or
if the flame extension
is more than 18 inches
long at a distance of
6 inches from the
valve opening.
All other pressurized
containers
II. Non-Pressurized Containers
A. flashpoint at or below
20°F.
B. Flashpoint above 20°F
and not over 80°F.
C. Flashpoint over 80°F
and not over 150°F.
D. Flashpoint above
150°F.
Required Label Statement
Extremely flammable.
Contents under pressure.
Keep away from fire, sparks,
and heated surfaces. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Flammable. Contents under
pressure. Keep away from
heat, sparks, and flame. Do
not puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Contents under pressure.
Do not use or store near
heat or open flame. Do not
puncture or incinerate
container. Exposure to
temperatures above 130°F
may cause bursting.
Extremely flammable. Keep
away from fire, sparks, and
heated surfaces.
Flammable. Keep away from
heat and open flame.
Do not use or store near
heat and open flame.
None required.
112
-------
APPENDIX C
CONTAINER DISPOSAL INSTRUCTIONS
143
-------
Appendix 0
CONTAINER DISPOSAL INSTRUCTIONS
The label of each product must hear container dlsposal
appropriate to the type of container.
instructions
1 . Domestic use products must bear one of the following
container disposal statements:
Container Type Statement
Non-aerosol products
(bottles, cans, .lars)
Non-aerosol products
(bags)
Aerosol products
Do not reuse container (bottle, can, Jar).
Rinse thoroughly before discarding in trash.
Do not reuse bag. Discard bag in trash.
Replace cap and discard containers in
trash. Do not incinerate or puncture.
All other products must bear container disposal Instructions,
based on container type, listed below:
Container Type
Statement
(Metal
containers
( non-aerosol)
Plastic containers
Glass containers
Fiber drums
with liners
Paper and
plastic bags
Compressed gas
cylinders
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or by
other procedures approved by state and local
authorities .
Triple rinse (or equivalent). Then offer
for recycling or reconditioning, or puncture
and dispose of in a sanitary landfill, or
incineration, or, ir allowed by state and
local authorities, by burning . If burned,
stay out of smoke.
Triple rinse (or equivalent). Then dispose
of in a sanitary landfill or by other
approved state and local procedures.
Completely empty liner by shaking and
tapping sides and bottom to loosen clinging
particles. Empty residue into application
equipment. Then dispose of liner in a
sanitary landfill or by incineration if
allowed by state and local authorities .
If drum is contaminated and cannot be
reused!, dispose of in the same manner.
Completely empty bag into application
equipment. Then dispose of empty bag in
a sanitary landfill or by incineration,
or, if allowed by State and local
authorities, by burning. If burned, stay
out of smoke.
Return empty cylinder for reuse (or
similar wording)
I/ Manufacturer may replace this phrase with one indicating
whether and how fiber drum may be reused.
-------
APPENDIX D
FARMWORKER SAFETY LABEL REQUIREMENTS
(PR NOTICE 83-2)
145
-------
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WASHINGTON. D.C. 20460
OFFICE OF
PESTICIDES AND TOXIC SUBSTANCES
MAR 2 9
PR NOTICE 83-2
NOTICE TO MANUFACTURERS, FORMULATORS
AND REGISTRANTS OF PESTICIDES
Attention: Persons Responsible for Federal Registrations of
Pesticides
This notice is to inform you that the labels of all outdoor
agricultural use products which are applied to crops whose
culture requires hand labor are required to bear the following
information under the Farmworker Safety Label Improvement Program.
No application for amended registration is required, provided
you use the exact wording contained in this Notice. All affected
products released for shipment after December 31, 1984 must be
relabeled accordingly.
For the purposes of this Label Improvement Program, the terms
"reentry intervals", "farmworkers", and "protective clothing"
used in this notice are as defined in 40 CFR 170.2. Reentry
interval means the period of time immediately following the
application of a pesticide to a field when unprotected workers
should not enter. Farmworker refers to any person or persons
engaged in agricultural hand labor in the field. Protective
clothing means, at least, a hat or other suitable head covering,
a long sleeved shirt and long legged trousers or a coverall type
garment (all of closely woven fabric covering the body, including
the arms and legs), shoes and socks.
The term hand labor tasks, as used in this Notice, is defined as
commonly recognized crop production activities such as harvesting,
detasselling, thinning, weeding, topping, planting, sucker removal,
summer pruning, moving irrigation equipment and other hand labor
tasks performed in the field by farmworkers who will come
in substantial contact with pesticide treated surfaces, such as
plants or plant parts. For the purposes of this notice, mixing,
loading, flagging, and equipment operation are considered to be
part of the application of the pesticide and are not normally
considered to be hand crop production tasks, and therefore, are
1H6
-------
Page 2
not subject to these provisions. At a minimum, the following
crops have been determined to employ hand labor tasks:
Citrus Fruit Onions Figs
Cucurbits Pome Fruits Mango
Fruiting Vegetables Stone Fruits Olives
Leafy Vegetables Tobacco Pineapples
Root Crop Vegetables Small Fruits (berries, grapes, nuts)
Corn (hybrid seed, sweet and pop)
Registrants are responsible for determining whether use of their
products would involve any other crop activities that meet the
definition for hand labor tasks normally performed by farmworkers
and are, thus, subject to this Notice.
While "scouting" for determining efficacy may result in potential
exposure, it is not considered to be a commonly recognized hand
labor crop production task customarily performed by farmworkers
and therefore would normally be excluded from the hand labor
criteria of this Notice. However, if the definition of hand
labor would cover scouting for a particular use, then these
provisions would apply.
I. PRODUCTS AFFECTED;
All products with Outdoor agricultural uses which are applied to
crops utilizing hand labor tasks will be required to bear general
precautionary label language about farmworker safety (see Section
II.A.) In addition, the labels of the following pesticides,
either as sole active ingredients or in combination with other
pesticides, must bear specific precautionary label language
about reentry and farmworker safety (see Section II. A. and B.).
Ethyl Parathion Monocrctophos Matasystox-R
Methyl Parathion Phosalone Bidrin
Azinphos Methyl Carbophenothion Ethion
Demeton Endrin
The requirements set forth in this Notice do not apply to: (1)
Mosquito abatement treatments and related public pest control
programs; (2) Greenhouse treatments; (3) Livestock and other
animal treatments; (4) Treatment of golf courses, forest uses
and similar nonagricuItural areas; (5) Any uses, except pesticides
with systemic modes of action, for which soil incorporation is
requ i red.
-------
Page 3
The reentry intervals for the eleven pesticides listed above and EPN
were established through regulation at 40 CFR 170. EPN was, excluded
from this label improvement action because an RPAR is currently
under negotiation. Registrants will be notified separately of
requirements resulting from the RPAR action.
EPA, as part of the reregistration process, is evaluating the
reentry intervals and protective clothing requirements tor all
pesticides including the ones addressed in this label improvement
program. Registrants will be advise-d through the Registration
Standards Program if future label changes are necessary.
11. REQUIRED LABEL CHANGES:
The following statements contain either the exact wording that
must appear on the affected product labels, or are explicit in
indicating the type of information that must be conveyed in
specific portions of the label text. See attached sample product
label for proper placement of each statement listed in this
Section (A and B).
A. General Worker Protection Statements;
The labels of all products covered by this notice must bear the
following general precautionary statements about farmworker
safety. See the sample label provided in attachment B for the
proper location for these statements.
1. "Do not apply this product in such a manner as to directly or
through drift expose workers or other persons. The area being
treated must be vacated by unprotected persons."
2. "It is a violation of Federal Law to use this product in a
manner inconsistent with its labeling."
3. The labels of all products in Toxicity Category I aruj II,
in addition to the English signal word, must include the
Spanish language equivalent on the front panel. The
appropriate Spanish signal word, "PELIGRO" (for DANGER) or
"AVISO" (for WARNING) must appear in capital letters of the
same type size as the equivalent English signal word.
148
-------
Page 4
4. Agricultural products in Toxicity Category I and II must
bear minimum Spanish language precautionary statements.
The following precautionary statement muse be placed on
the label in proximity to the Spanish signal word:
"PRECAUCION AL USUARIO: Si usted no lee ingles, no use
este producto hasta que le etiqueta haya sido explicado
ampliamente".
(TRANSLATION: TO THE USER: IE you cannot read English, do
not use this product until the label has been fully explained
to you. The English translation oE the Spanish precautionary
statement is not required to appear on your product label.) "
5. All agricultural use products applied to crops utilizing
hand labor tasks, except as specified in Section B (1) oE
this Notice, must bear the following label statement:
"Do not enter treated areas without protective clothing
until sprays have dried (or, if appropr ia r r?, ousts have
sett led ) . "
6. "Because certain states may require more restrictive
reentry intervals for various crops treated with this
product, consult your State Department oE Agriculture for
Eurther inEormation."
7. "Written or oral warnings must be given to workers who are
expected to be in a treated area or in an area about to be
treated with this product. (Indicate speciEic oral warnings
which inform workers of areas or fields that may not be
entered without specific protective clothing, period of
time field must be vacated and appropriate actions to take
in case of accidental exposure.) when oral warnings are
given, warnings shall be given in a language customarily
understood by workers. Oral warnings must be given if
there is reason to believe that written warnings cannot be
understood by workers. Written warnings must include the
following information: (Appropriate signal word DANGER or
WARNING). Area treated with (name of pesticide) on (date
of application). Do not enter without appropriate protective
clothing for (insert here reentry interval for your product).
(insert here actions to take in case of accidental
exposure.)1" This statement may either appear on the label
(see Attachment B for specific location) or on the labeling
accompanying the product.
119
-------
Page 5
B. Specific Reentry and Farmworker Safety Statements;
Because of their inherent human toxicity and to reduce risks for
crop use patterns utilizing hand labor, the Agency has determined
that all products with reentry intervals established through
40 CFR 170 must bear the following label statement:
"Do not enter treated areas for (insert here appropriate
reentry time interval from chart below ) hours unless
appropriate protective clothing is worn."
Reentry Intervals
Ethyl Parathion . .
Metasystox-R
Methyl Parathion.
Azinphos Methyl . .
.48
4R
.48
. 24
hrs .
hrs .
hrs .
hrs .
Monocrotophos . . .
Phosalone
Carbophe noth ion .
Endr i n
.48
. 24
.48
48
hrs .
hrs .
hrs.
hrs .
Demeton .
Bidrin. .
Ethion. .
. .48
. .48
..24
hrs.
hrs.
hrs.
III. Compliance:
tt is the responsibility of the registrants to ensure that the
labels of their products, including distributor products, contain
specific instructions pertaining to farmworker safety. Existing
stocks of products in channels of trade (that is, out of the
registrant's physical possession) prior to December 31, 1984,
need not be relabeled. All products released for shipment after
December 31, 1984, must meet the requirements of this Notice, or
they will be deemed misbranded under Section 2(q)(l)(G). Failure
to revise product labeling in accordance with this Notice may
also result in the initiation of cancellation proceedings.
If you wish to make changes not specified in this Notice, or to
modify any of the required statements, you must submit an
application for amended registration to the address listed below:
(Product Manager for your product listed in Attachment A)
Registration Division (TS-767-C)
U.S. Environmental Protection Agency
150
-------
Page 6
IV. Further Information:
Questions on this Notice may be directed to the appropriate Product
Manager or Richard King, Policy & Liaison Staff, Registration
Division, at (703) 557-0592.
Douglas u>. Campt, Director
Registra'tion Division (T^-767-C)
Attachments
A. Product Manager Assignments
B. Sample Product Label
151
(152 - Attachment A. Product Manager Assignments not Included)
-------
ATTACHMENT B - Sample Label
Label
Statements
A( 1)
Choice, of
ono location
PDECAUtlONAflY SlAlEMENIS
MA^AHDS IO HUMANS
(» DOMESTIC ANIMALS]
OANGEfl
STORAGE AND
DISPOSAL
DISPOSAL :- —. -.-
CHOP
A( 3)
Equivalent
Spanish
Signal
Word
RESTRICTED USE
PESTICIDE
(Oc icLjil s.'ilo to J'») us«? oixJy by Cc
01 |.<;r.':oiis uivliT llK'ir .1iti.-ct
;uii.-iy i sion .^uj only lor U>">se usti covered
<.\,- i"i:itil':->t ;,j/|>l lo.iidr'G cort i f ic-ic ion.
PRODUCT
NAME
KGCPOUTOF
DANGBFT—POISON
jtAltMllll t" 1'HAvMH.Al (III All.ttKl
rHLUAUlK)NAIU 'jIAILMLNIS
tSI AIIII-JllMLHl "O • —
A(4)
ish
.->u a no men t
Hoqardi 119
Liubilif. y t
1 iif
-------
APPENDIX R
FIFRA §3(c)(2)(B) SUMMARY SHEET
(EPA FORM 8580-1)
-------
OMB Approval No. 200O0468
FIFHA SECTJON 3(C)(2)(8) SUMMARY SHEET
EPA REGISTRATION MO.
PRODUCT NAME
APPLICANTS NAME
DATE GUIDANCE DOCUMENT ISSUED
With respect to th« requirement to tubfflit "gensric" data imposed by the flfRA action 3(C)(2)(S) nones contained in tri?
Guidance Document, I am responding in the following manner:
I will submit data in a timely manner to satisfy the following requirements. If the test procedures I will ate deviate irom (or are not
specified in) the Registration Guidelines or the Protocols contained in the Reports of Expert Groups to the Chemicals Giouo. OECD
Chemicals Testing Programme, I enclose the protocols that I will use:
CD 2. I hjve an tared into an agreement with or* or more other registrant! under FIFRA action 3(C)(2)(8)(iil to satisfy the following data
requirements. The tetts, and any required protocols, will be submitted to EPA by:
NAME OF OTHER REGISTRANT
CD 2. I unclose a completed "Certification of Attempt to Enter Into an Agreement with Other Registrants for Development of O^n" -A.
respect to the following data requirements:
I 14. I request that you emend my registration by deleting the following uses Ithii option is not available to applicants for new products):
I requot voluntary conciliation of the registration of this product. (This option it not available to applicants for new products.)
REGISTRANT'S AUTHORIZED REPRESENTATIVE
SIGNATURE
DATE
EPA form 8680-1 HO421
155
-------
APPENDIX P
CERTIFICATION OP ATTEMPT TO ENTER INTO
AN AGREEMENT WITH OTHER REGISTRANTS
POR DEVELOPMENT OP DATA
(EPA FORM 8580-6)
156
-------
OMB Approval No. ZOOfXHSS.
(To qutltfy. certify ftLi, four n«tnt>
CERTIFICATION OF ATTEMPT TO ENTER
INTO AN AGREEMENT WITH OTHER REGISTRANTS
FOR DEVELOPMENT OF DATA
1. I «m duly authorized to reprewnt the following firm(s) who are subject to the require-
menti of a Notice under FlFRA Section 3(c)(2)(8) contained in a Guidance Document
to submit data concerning the active ingredient:
GUIDANCE DOCU"
ACTIVE INGREDIENT
NAME OF FIRM
EPA COMPANY NUMBER
(This firm or group of firms is referred to below as "my firm".)
2. My firm is willing to develop and submit the data as required by that Notice, if necessary However, my firm would prefer to enter
into an agreement with one or more other registrants to develop jointly, or to shaie in the cost of developing, the following required
items or data:
3- M> lirn has ottered in writing to enter into such an agreement. Copies ol the oilers are attached T'ljt ofter was irrevocable and included in offer to Be
oound by an arbitration decision under FlFRA Section 3(cll2)(8){iii) it Imal agreement on all terms could not tie reached otherwise. This otler was made
10 tne following firmlsl on the following deteul:
NAME OF FIRM
DATE OF OFFER
However, none of those fifm(s) accepted my offer.
4. My firm requests that EPA not suspend the registration(s) of my firm's product(s). if any of the firms named in paragraph (3) above
have agreed to submit the data listed in paragraph (21 above in accordance with the Notice. I understand EPA will promptly inform
me whether my firm must submit data to avoid suspension of its registration(s) under FlFRA Section 3(c)(2)(B). (This statement
doe* not apply to applicants for new products.) I give EPA permission to disclose this statement upon request.
VPEO NAME
SIGNATURE
DATE
EPA Form 8S80-6 (10-821
157
-------
APPENDIX G
FORMULATOR'S EXEMPTION STATEMENT
158
-------
FORMULATOR'S EXEMPTION STATEMENT
(40 CFR 152.85)
EPA File Symbol/Reg. No. Product Name
Applicant's Name and Address
As an authorized representative of the applicant for registration of the
product identified above, I hereby certify that:
(1) This product contains the active ingredient(s):
(2) Each active ingredient Listed in paragraph (1) is present solely
as the result of the incorporation into the product (during formulation or
packaging) of another product which contains that active ingredient, which
is registered under FIFRA sec. 3, and which is purchased bv us from another
producer.
(3) Indicate by circling (A) or (8) t>?low which pangraph applies:
(A) An accurate Confidential Statement of Formula (KPA Form 8570-4) for
the above identified product is attached to this statement. That formula
statement indicates, by company name, registration number and product
name, the source of the active ingredient(s) I isted in paragraph (1).
OR
(B) The Confidential Statement of Formula dated on file with
the F.PA is complete, current and accurate and contains the information
reguired on the current CSF Form No. 8570-4. The registered source(s)
of the active ingredientfs) listed in paragraph (1) is/are listed below:
Active ingredient Source: Product name and Reg. No.
Signature
Hate Title
EPA Form (April 1985)
159
-------
BIBLIOGRAPHY
160
-------
Guide to Use of This Bibliography
1. CONTENT OP BIBLIOGRAPHY. This bibliography contains
citations of all studies considered relevant by EPA in
arriving at the positions and conclusions stated elsewhere
in the Standard. Primary sources for studies in this
bibliography have been the body of data submitted to EPA
and its predecessor agencies in support of past regulatory
decisions. Selections from other sources including the
published literature, in those Instances where they have
been considered, will be Included.
2. UNITS OP ENTRY. The unit of entry in this bibliography
is called a "study." In the case of published materials,
this corresponds closely to an article. In the case of
unpublished materials submitted to the Agency, the Agency
has sought to Identify documents at a level parallel to
the published article from within the typically larger
volumes in which they were submitted. The resulting
"studies" generally have a distinct title (or at least a
single subject), can stand alone for purposes of review,
and can be described with a conventional bibliographic
citation. The Agency has attempted also to unite basic
documents and commentaries upon them, treating them as a
s i ng 1 e s t ud y .
3- IDENTIFICATION OF ENTRIES. The entries In chis bibliography
are sorted numerically by "Master Record Identifier," or
MRID, number. This number Is unique to the citation, and
should be used at any time specific reference is required.
It is not related to the six-digit "Accession Number"
which has been used to identify volumes of submitted
studies; see paragraph ^(d)(^4) below for a further explana-
tion. In a few cases, entries added to the bibliography
late In the review may be preceded by a nine-character
temporary Identifier. These entries are listed after
all MRID entries. This temporary identifier number is
also to be used whenever specific reference is needed.
4. FORM OF ENTRY. In addition to the Master Record Identifier
(MRID) , each entry consists of a citation containing
standard elements followed, in the case of material
submitted to EPA, by a description of the earliest known
submission. Bibliographic conventions used reflect the
standards of the American National Standards Institute
(ANSI), expanded to provide for certain special needs.
161
-------
Author. Whenever the Agency could confidently identify
one, the Agency has chosen to show a personal author.
When no individual was Identified, the Agency has
shown an identifiable laboratory or testing facility
as author. As a last resort, the Agency has shown
the first submitter as author.
Document Date. When the date appears as four digits
with no question marks, the Agency took it directly
from the document. When a four-digit date is followed
by a question mark, the bibliographer deduced the
date from evidence in the document. When the date
appears as (19??). the Agency was unable to determine
or estimate the date of the document.
Title. In some cases, it has been necessary for
Agency bibliographers to create or enhance a document
title. Any such editorial insertions are contained
between square brackets.
Trailing Parentheses. For studies submitted to the
Agency in the past, the trailing parentheses include
(in addition to any self-explanatory text) the follow-
ing elements describing the earliest known submission:
(1) Submission Date. The date of the earliest known
submission appears immediately ro 11.owing the word
"rece ived ."
(2) Administrative Number. The next element,
Immediately following the word "under," is the
registration number, experimental use permit
number, petition number, or other administrative
number associated with the earliest known submission
(3) Submitter. The third element is the submitter,
following the phrase "submitted by." When
authorship is defaulted to the submitter, this
element is omitted.
( ^4) Volume Identification (Accession Mumber) . Th e
final element in the trailing parentheses
identifies the EPA accession number of the volume
in which the original submission of the study
appears. The six-digit accession number follows
the symbol "CDL," standing for "Company Data
Library." This accession number is in turn
followed by an alphabetic suffix which shows the
relative position of the study within the volume.
For example, within accession number 123^56, the
first study would be 123^56-A; the second, 123^56-B;
the 26th, 123^56-Z; and the 27th, 123U56-AA.
162
-------
OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Cryzalin Standard
MRID CITATION
00023990 Elanco Products Company (1969) Oryzalin--?ruit and Nut Crocs.
(Unpublished study received Sep 1, 1976 under 6?i859; CDL:
098067-K)
00026081 Probst, G.W. (1979) tonitoring and Exposure Cata on Oryzalin. (Un-
published study received Dec 12, 1979 under 1471-96; submitted
by Elanco Products Co., Div. of Eli Lilly and Co., Indianapolis,
Ind.; CDL:241536-Z)
00026084 Eli Lilly and Company (1972) Technical Report on EL-119: A New
Experimental Herbicide. Indianapolis', Ind.: Elanco Products
Co. (Also in unpublished submission received Dec 12, 1979 under
1471-96; submitted by Elanco Products Co., Div. of Eli Lilly and
Co., Indianapolis, Ind.; CDL:241536-AC)
00026592 Eli Lilly and Company (1975) Technical Report on Surflan (R): A
Selective, Surface-Applied, Prsemerger.ee Herbicide. Indianap-
olis, Ind.: Eli Lilly. (Also in unpublished submission received
Dec 12, 1979 under 1471-96; submitted by Elanco Products Co.,
Div. of Eli Lilly and Co., Indianapolis, Ind.; CDL:241536-AR)
00026757 Elanco Products Company (19??) The Safety Evaluation of Oryzalin,
ELI19. (Unpublished study received Dec 12, 1979 under !47n-96;
CCL:241537-A)
00026761 Berg, D.H.; Errmerson, J.L. (1968) Studies on the Absorption and Ex-
cretion of Compound 67019 in Rats. (Unpublished study received
Dec 12, 1979 under 1171-96; submitted by Elanco Products Co.,
Div. of Eli Lilly and Co., Indianapolis, Ind.; CDL:241537-G)
00026762 Arthur, 3.H.; Worth, H.M.; Hoffman, D.G.; et al. (1972) Guinea Pig
Sensitlzation Study with EL-119: Study G-D-7-72. (Unpublished
study received Dec 12, 1979 under 1471-96: submitted by Elanco
Products Co., Div. of Eli Lilly and Co., Indianapolis, Lnd.;
CDL:241537-H)
163
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OFFICE OP PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Oryzalin Standard
MRJD CITATION
00025759 Elanco Products Ccr.pany (19??) Acute Inhalation Toxicity of Surfian
4 AS in Pats: Study R-K-13-75. (Unpublished study received Dec
12, 1979 under 1471-96; CDL:2^1537-?)
00026773 Kitchen, D.N.; Hoffman, D.G.; Todd, G.C.; et al. (1979) Tne Toxico-
Icgical Evaluation of Oryzalin (Compound 67019) Given to Mice in
the Diet for Three f-fonths: Study M-9276. (Unpublished study re-
ceived Dec 12, 1979 under 1471-96; submitted by Elanco Products
Co., Div. of Eli Lilly and Co., Indianapolis, Ind.; CDL:
241537-T)
00026776 Kitchen, D.M.; Hoffman, D.G.; Todd, G.C.; et al. (1978) The Toxico-
logical Evaluation of Oryzalin (EL-119) Given to Rats in the Di-
et for One Year: Study R-157. (Unpublished study received Dec
12, 1979 under 1471-96; submitted by Elanco Products Co., Div.
of Eli Lilly and Co., Indianapolis, Ind.; CDL:241537-X)
00026780 Elanco Products Company (1979) Interim Status Report: Chronic Feed-
ing Studies—Repeated Oral Exposure 2-Year Mouse. (Unpublished
Study recieved Dec 12, 1979 under 1471-96; CDL:241537-AI)
00025731 iMarkham, J.K.; Adams, E.R.; Hoffman,D.G.; et al. (1972) A Teratol-
ogy Study with EL-119 in the Rat: Study R-22. (Unpublished
Study received Dec 12, 1979 under 1471-96; submitted by Elanco
Products Co., Div. of ELI Lilly and Co., Indianapolis, Ind.;
CDL:241537-AF)
00026782 Markham,J.K.; Blubaugh, M.M.; Kitchen, D.N.; et al. (1978) A Pilot
Reproduction Study on Lilly Conpound 67019, Oryzalin, in the
Rat: Study No. R-926 (Unpublished study recieved Dec 12, 1979
under 1471-96; submitted by Elanco Products Co., Div. of Eli
Lilly and Co., Indianapolis, Ind.; CDL:241537-AG)
00026788 Hoffman, D.G. (1972) Personnel Experiences frcm Handling El 119.
(Unpublished study received Dec 12, 1979 under 1471-96; submit-
ted by Elanco Products Co., Div. of Eli Lilly and Co., Indianap-
olis, Ind.; CDL:241537-AM)
00027289 Kitchen, D.N.; Arthur, B.H.; Gibson, W.R.; et al. (1977) Summary of
Acute and Subacute Toxicity Studies of Surfian 4 AS. Summary of
studies 241537-M through 241537-R. (Unpublished study received
Dec 12, 1979 under 1471-96; submitted by Elanco Products Co.,
Div. of ELI-Lilly and Co., Indianapolis, Ind.; CDL:241537-K)
00033976 Sieck, R.P.; Barton, S.J. (1972) Determination of. EL-119 in Crops.
Method no. 5801615 dated Mar 29, 1972. (Unpublished study re-
ceived Nov 30, 1973 under 1471-EX-41; submitted by Elanco Prod-
ucts Co., Div. of Eli Lilly and Co., Indianapolis, Ind.; CDL:
126699^3)
164
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OFFICE OF PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Oryzalin Standard
MRID CITATION
CCC5-3150 Thompson, C.Z.; Mc.vahon, H.S.; Kress, T.J. (1979) The Effect of
Lilly Compound 67019, Cry sal in, upon Bacterial Systans Knc'.vn
To Detect Mitagenic Events. (Unpublished study received on
unknown date under 1471-96; submitted by Elanco Products Co.,
Dlv. of Eli Lilly and Co., Indianapolis, Ind.; CDL:242442-C)
00038668 Worth, H.M. ; Anderson, R.C., eds. (1971) The Safety Evaluation of
Oryzalin, EL 119. (Unpublished study received on unknown date
under 1471-96; submitted by Elanco Products Co., Div. of Eli
Lilly and Co., Indianapolis, Ind.; CDL:242443-A)
00033672 Elanco Products Company (19??) Subacute Dermal Toxicity Study — Rab
bits: Study 3-705-71. (Unpublished study received on unknown
date under 1471-96; CDL:242443-J)
00038673 Kitchen, D.N. ; Arthur, B.H. ; Gibson, W.R.; et al. (1977) Acute and
Subacute Toxicity Studies of Surflan U AS (43% by Weight Com-
pound 67019): Toxicology Submission No. 5« (Unpublished study
received on unknown date under 1471-96; submitted by Elanco
Products Co., Div. of Hi Lilly and Co., Indianapolis, Lid.;
00038677 Kitchen, D.N. ; Carter, J.L. ; Hoffman, D.G.; et al. (1979) The Toxi-
cological Evaluation of Cryzalin (Conpour.i 67019) Given Co Pats
in tne Diet for Three Months: Toxicology Study R-686. Includes
method AUQ dated Jun 1979 entitled: Determination of Oryzalin
(3,5-Dinitro-4N,4N-dipropylsulfanilamide) in formulations and
technical products by high pressure liquid chrcmatography. (Un-
published study received on unknown dace under 1471-96; submit-
Ced by Elanco Products Co., Div. of Eli Lilly and Co., Indianap-
olis, Ind.; CDL:242443-S)
00033631 Kitchen, D.N. ; Hoffman, D.G.; Todd, G.C.; et al . (1979) The Tbxi-
cological Evaluation of Oryzalin (Compound 67019) Given Co Mice
in the Diet for One Year: Study M-9137. Includes method AUQ
dated Jun 1979 entitled: De Germination of Oryzalin (3,5-Dinitro-
4N>4N-dlpropylsulfanilamide) in formulations and technical prod-
ucts by high pressure liquid chroma tog raphy and method no.
5801677 entitled: Determination of volatile Nitrosamines in
technical products and formulations of Dinitroaniline herbi-
cides. (Unpublished study received on unknown date under 1471-
96; submitted by Elanco Products Co., Div. of Eli Lilly and Co.,
Indianapolis, Ind.; CDL:242U43-W)
165
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CFPICE OP PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Oryzalin Standard
XRID CITATION
00038682 Markhan, J.K.; Blubaugh, M.M.; Kitchen, D.N.; et al. (1973) A Tera-
tology Study on Lilly Compound 67019, Oryzalin, in the Rat:
Study No. R-1186. (Unpublished study including study no. R-926,
received on unknown date under 1471-96; submitted by Elanco
Products Co., Dlv. of Eli Lilly and Co., Indianapolis, Ind.;
CDL:242443-AA)
00033774 Carter, E.N.; Dayton, R.P.; Price, P.W.; et al. (1979) Reports
or Inquiries to Eli Lilly and Company Concerning the Manufacture
of Oryzalin and Che Formulation or Use of Surflan (R). (Un-
published study received on unknown date under 1471-96; pre-
pared In cooperation with Southern Dyestuff Co. and Tippecanoe
Laboratories, submitted by Elanco Products Co., Div. of Eli
Lilly and Co., Indianapolis, Ind.; CDL:242444-D)
00041970 Arthur, B.H. (1968) Letter sent to H.M. Worth dated Mar 21, 1968,
Dermal toxicity and eye irritation—Compound 67019. (Unpub-
lished study received on urvknown date under 1471-96; submitted
by Elanco Products Co., Div. of Eli Lilly and Co., Indianapolis,
Ind.; CDL:242443-B)
000^2908 Carter, J.L.; Adams, E.R.; Cwen, N.V.; et al. (1980) A Multi-Gener-
ation Study wich Conpeur.ci 57019 in cr.e Rat: Studies R-1226,
R-327, R-647. (Unpublished study received Peb 5, 1980 under
1471-96; submitted by Elanco Products Co., Div. of Ell Lilly and
Co., Indianapolis, Ind.; CDL:241?42-A)
00042910 Thompson, C.Z.; McMahon, R.E.; Kress, T.J. (1979) The Effect of
Lilly Compound 30545 upon Bacterial Systems Known 1b Detect Mu-
tagenic Events. (Unpublished study received Peb 5, 1980 under
1471-96; submitted by Elanco Products Co., Div. of ELi Lilly and
Co., Indianapolis, Ind.; CDL:241742-E)
00042911 Thompson, C.Z.; McMahon, R.E.; Kress, T.J. (1979) The Effect of
Lilly Compound 56277 upon Bacterial Systems Known To Detect Mu-
tagenic Events. (Unpublished study received Peb 5, 1980 under
1471-96; submitted by Elanco Products Co., Div. of Eli Lilly and
Co., Indianapolis, Ind.; CDL:241742-P)
00044332 Carter, J.L.; Todd, G.C.; Hofttnan, D.G.; et al. (1980) The Toxi-
colcgical Evaluation of Oryzalin (Compound 67019) Given to
Fischer 344 Rats in the Diet for Two Years: Studies R-167 and
R-177. (Unpublished study received Jul 24, 1980 under 1471-96;
submitted by Elanco Products Co., Div. of Eli Lilly and Co.,
Indianapolis, Ind.; 099517-A, 099518)
166
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OFFICE OP PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Oryzalin Standard
MRJD CITATION
00066198 Elanco Products Company (1976) Summary—Human Safety, Domestic
Animal Safety. (Unpublished study received Sep 16, 1977 under
1471-96; CDL:23l325-J)
00066220 Atkins, E.L., Jr.; Anderson, L.D.; Kellura, D.; et al. (1976)
Protecting Honey Bees from Pesticides. ?: tihiv. of California,
Div. of Agricultural Sciences. (Leaflet 2883; also in unpub-
lished submission received Mar 20, 1980 under 432-502; sub-
mitted by Penick Corp., Lyndhurst, N.J.; CDL:243536-3)
00070569 Tcdd, G.C. (1981) Ccmpound 67019, Studies R-167 and R-177. (Unpub-
llshed study received Mar 5, 1981 under 1471-96; submitted by
Elanco Products Co., Div. of Eli Lilly and Co., Indianapolis,
Ind.; CDL:099928-A)
00068079 Carter, J.L.; Owen, N.V.; Todd, G.C.; et al. (1981) The lexicolog-
ical Evaluation of Oryzalin (Compound 67019) Given to 36C3P1
Mice in the Diet for Two Years: Studies M-9087 and M-9097. (rJn-
published study received Apr 2, 1981 under 1471-96; submitted by
Elanco Produces 'Co., Div. of £11 Lilly i Co., Ladianapolis,
Ind.; CDL:244746-A; 244747; 244748)
00072593 Carter, J.L.; Negilski, D.S.; Kehr, C.C.; et al. (1980) The Toxic-
ity of Compound 67019 (Gryzalin) to Bobwnite Cuail In a ?ive-
'iay Dietary Study: Study :b. A010-79- L-.eludes undated method
ATY. (Unpublished study received May 7, 1981 under 1471-96;
submitted by Elanco Products Co., Div. of Eli Lilly and Co.,
Indianapolis, Ind.; CDL:245053-A)
00072594 Carter, J.L.; Negilski, D.S.; Kehr, C.C.; et al. (1980) The Toxic-
icity of Ccmpound 67019 (Oryzalin) to Mallard Ducks In a Five-
day Dietary Study: Study No. 7005-79. Includes undated method
ATY. (Unpublished study received -May 7, 1981 under 1471-96;
submitted by Elanco Products Co., Div. of Eli Lilly and Co.,
Indianapolis, Ind.; CDL:245054-A)
00072595 Sleight, B.H., III (1971) Acute Toxicity of EL-119 Co Bluegill
(Lepomis macrochlrus) and Rainbow Trout (Salmo gaird-
neri). (Unpublished study received May 7, 1981 under 1471-
96; prepared by Bionomics, Lac., submitted by Elanco Products
Co., Div. of Eli Lilly & Co., Indianapolis, Ind.; CDL:245055-A)
167
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OFFICE OP PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Wider the Oryzalin Standard
MRJD CITATION
00072596 Carter, J.L.; Kamak, R.S.; Kehr, C.C.; et al. (1980) The Toxicity
of Conpound 67019 (Oryzalin) to Daphnia magna In a 48-hour
Static Tesc: Study Nos. 5005-79 and 5012-79. (Unpublished study
received May 7, 1981 under 1471-96; submitted by ELanco Products
Co., Div. of Eli Lilly & Co., Indianapolis, Ind.; CDL:245056-A)
00073552 Kitchen, D.N.; Markham, J.K.; Brannon, D.R.; et al. (1979) A Ter-
atology Study on Lilly Compound 67019 (Oryzalin) in the Rabbit:
Study B-7366. (Unpublished study received Oct 30, 1979 under
1471-96; submitted by Elanco Products Co., Div. of Eli Lilly
and Co., Indianapolis, Lnd.; CDL:241232-A)
0008^886 Golab, T.; Wooten, H.L.; Shuey, E.W. (1980) Balance-excretion and
Ffetabolism Study of 14C Oryzalin in a Steer. (Unpublished
study received Oct 22, 1981 under 1471-96; submitted by Elanco
Products Co., Div. of Eli Lilly and Co., Indianapolis, Ind.;
CDL:246113-E)
00086301 Prcbsc, G.S.; Hill,. L.E.; Jordan, W.H.; et al. (1981) The Effect of
Oryzalin (Lilly Compound 67019) on the Induction of DMA Repair
Synthesis in Primary Cultures of Adult Rat Hepatocytes: Study
810217-337-UDS. (Unpublished study received Nov 19, 1981 under
1471-96; submitted by Elanco Products Co., Div. of Eli Lilly and
Co., Indianapolis, Ind.; CDL:2^6259-A)
00087801 Probst, G.S.; Meal, S.3.; Jordan, W.H.; et al. (1981) Tne Effect of
Oryzalin (Compound 67019) on the in vivo Induction of Sister
Chromatic Exchange in Bone Marrow of Chinese Hamsters: Studies
810601 SCE, 810707SCE, 810707SCE. (Unpublished study received
Dec L7, 1981 under 1471-100; submitted by Elanco Products Co.,
Div. of Eli Lilly and Co., Indianapolis, Ind.; CDL:2464i2-E)
00088513 Kitchen, D.N.; Arthur, B.H.; Gibson, W.R.; et al. (1977) Acute
Toxicity: Surflan 4 AS. (Unpublished study received May 1,
1978 under 1471-112; submitted by Elanco Products Co., Div. of
Eli Lilly and Co., Indianapolis, Ind.; CDL:233839-P)
00094414 Arthur, B.H. (1968) Dermal Toxicity and Eye Irritation—Compound
67019. (Unpublished study received Dec 12, 1979 under 1471-96;
submitted by Elanco Products, Co., Div. of Eli Lilly and Co.,
Indianapolis, Ind.; CDL:241537-C)
168
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OFFICE OP PESTICIDE PROGRAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Part of the Data Base Supporting
Registrations Under the Oryzalin Standard
MRID CITATION
00098U61 Jordan, W.H.; Byrd, R.A.; Markhara, J.K.; et al. (1982) A Replicated
Teratology Study on Oryzalin (EL-119, Conpound 67019) by the
Oral Route in Dutch Belted Rabbits: Study Nbs. B7281 and B7291.
(Unpublished study received Apr 8, 1982 under 1471-96; submitted
by Elanco Products Co., Div. of Eli Lilly and Co., Indianapolis,
Ind.; CDL:247229-A)
00098462 Cochrane, R.L.; Kehr, C.C.; Jordan, W.H.; et al. (1982) The Tox-
icity of Oryzalin (EL-119, Compound 67019) to Bobwhite in a 14-
day Acute Oral Study: Study A02980. (Unpublished study received
Apr 8, 1982 under 1471-96; submitted by Elanco Products Co.,
Div. of Eli Lilly and Co., Indianapolis, Ind.; CDL:247229-3)
00098463 Hoffman, D.G.; Bridge, T.L.; Lobb, K.L.; et al. (1982) Percutaneous
Absorption of l4C-Oryzalin in Monkeys: Studies M-6231 and
M-6012. (Unpublished study received Apr 8, 1982 under 1471-96;
submitted by Elanco Products Co., Div. of Eli Lilly and Co.,
Indianapolis, Ind.; CDL:247229-C)
00098464 Cochrane, R.L.; Kehr, C.C.; Jordan, W.H.; et al. (1982) The Toxic-
ity of Oryzalin (EL-119, Compound 67019) to Bobwhite in a 14-day
Acute Oral Study: Study A03580. (Unpublished study received
Apr 8, 1982 under 1471-96; submitted by Elanco Products Co.,
Div. of Eli Lilly and Co., Indianapolis, Lr.d.; CDL:247229-D)
00106660 Elanco Products Co. (1971) Inhalation Toxicity, Rat: Oryzalin:
Study No. R-H-9-71. (Unpublished study received Jun 18, 1972
under 2G1201; CDL:091019~C)
00106663 Elanco Products Co. (1968) Environmental Bioassay, Pish: Oryza-
lin. (unpublished study received Jun 18, 1972 under 2G1201;
CDL:091019-F>
00106664 Arthur, B.; Worth, H., ed. (1971) Subacute Dermal Toxicity Study--
Rabbits: Study 8-705-71. (Unpublished study received Jun 18,
1972 under 2G1201; submitted by Elanco Products Co., Div. of
Eli Lilly and Co., Indianapolis, IN; CDL:091019-G)
00106665 Worth, H. (1971) Effect of a Season-long Exposure to Oryzalin on
Fathead Minnow Production. (Unpublished study received Jun 18,
1972 under 2Q1201; submitted by Elanco Products Co., Div. of
Eli Lilly and Co., Indianapolis, IN; CDL:091019~H)
00106666 Elanco Products Co. (19??) The Safety Evaluation .of Oryzalin,
EL119. (Unpublished study received Jun 18, 1972 under 2G1201;
CDL: 091019-D
169
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OFFICE OF PESTICIDE PROCflAMS
REGISTRATION STANDARD BIBLIOGRAPHY
Citations Considered to be Bart of the Data Base Supporting
Registrations Under the Oryzalin Standard
.•••RID CITATION
00106667 Elanco Products Co. (1968) Single Exposure Effects: Oryzalin.
(Unpublished study received Jun 18, 1972 under 2G1201; CDL:
091019-J)
00106670 Owen, N. (1968) Oryzalin: Dog Study D-100-67. (Unpublished study
received Jun 18, 1972 under 2G1201; submitted by Elanco Products
Co., Div. of Eli Lilly and Co., Indianapolis, IN; CDL:091019-M)
00106681 Arthur, B. (1971) Dermal Toxicity and Eye Irritation—Surflan (Re-
search No. 67019). (Unpublished study received Dec 29, 1972
under 3F1347; submitted by Elanco Products Co., Div. of Eli
Lilly and Co., Indianapolis, IN; CDL:093606-C)
00106728 West, H.; Kehr, C.; Hoffman, D.; et al. (1972) The Acute Cral
Toxicity of Technical EL-119 In Bobwhite Quail and Mallard
Ducks. (Unpublished study received Dec 22, 1972 under 3-pi3-7;
submitted by Elanco Products Co., Div. of Eli Lilly and Co.,
Indianapolis, IN; CDL:092131-AL)
00106729 Elanco Produces Co. (1963) Envirormencai Exposure of Cryzalin to
Goldfish: Acute Toxicity. (Unpublished study received Dec 22,
1972 under 3F1347; CDL:092131-AO)
00106730 Ward, N.; Donoho, A.; Sullivan, W. (1971) Determination of Oryzalin
in Crops: Procedure 5801603. (Unpublished study received 1971
under unknown admin no.; submitted by Elanco Produces Co., Div.
of Eli Lilly and Co., Indianapolis, IN; CDL:125l65-A)
00115743 .Hoyt, J.; Jordan, W.; Owen, N. (1982) A Dominant Lethal Study with
Oryzalin ... in the Wlstar Pat: Study R06082. (Unpublished
study received Oct 21, 1982 under 1471-96; submitted by Hanco
Products Co., Div. of Eli Lilly and Co., Indianapolis, IN; CDL:
248616-A)
00126841 Sauter, S.; Meyerhoff, R.; Jordan, W.; et al. (1983) Tne Toxicity
of Oryzalin (EL-119, Compound 67019) in Water to Fathead Minnows
... in a 34-day Early Life-stage Study: Study F11482. (Unpub-
lished study received Apr 14, 1983 under 1471-96; submitted by
Elanco Products Co., Div. of Eli Lilly and Co., Indianapolis,
IN; CDL:071521-A)
00126842 Meyerhoff, R.; Sauter, S.; Jordan, W.; et al. (1983) The Toxicity
of Oryzalin (EL-119, Compound 67019) in Water to Rainbow Trout
... in a 66-day Early Life-stage Study: Study F11382. (Unpub-
lished study received Apr 14, 1983 under 1471-96; submitted by
Elanco Products Co., Div. of Eli Lilly and Co., Indianapolis,
IN; CDL:071521-B)
170
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OFFICE OP PESTICIDE PROGRAMS
REGISTRATION STANDAJID BIBLIOGRAPHY
Citations Considered to be Part of the Data Sase Supporting
Registrations Under the Cryzalin Standard
MRID CITATION
001253^3 Cochrane, R.; Jordan, W.; Branr.on, D.; et al. (1982) The Toxicity
of Cryzalln (5L-119, Compound 57019) in a Cne-generation Study
with Mallards: Stuiy A00^32. (Unpublished study received Apr
14, 1983 under 1U71-96; submitted"by ELanco Products Co., Div.
of Eli Lilly and Co., Indianapolis, IN; CDL:07152l-C)
000129050 Cochrane, R.; Jordan, W.; Brannon, D.; et al. (1983) The Toxicity
of Oryzalin (EL-119, Corapotjnd 67019) in a One-generation Repro-
duction Study with Bobwhite: Study A01282. (Unpublished study
received Jun 3, 1983; Jun 8, 1983 under 1U71-96; submitted by
Elanco Products Co., Div. of Eli Lilly and Co., Indianapolis,
IN; CDL:250589-A)
00130427 Rexroat, M.; Jordan, W.; Probst, G.; et al. (1983) The Effect of
Cryzalin (Conpound 67019) on the Induction of Reverse .'-tucacicns
in Salmonella typhlmurium Using the .Ames lest: Study
83021UAMS1188. (Unpublished ^study received Aug 11, 1?85 urxler
1^71-96; submitted by Elanco Products Co., Div. of Eli Lilly and
Co., Indianapolis, IN; CDL:25L210-A)
C0133696 Koyt, J.; Markham, J.; Johnson, W.; ec il. (1983) A Dominant Lethal
Study with Triethylenemelamine (TET-l) La the Wlstar Rat: Study
No. R00383. (Unpublished study received "eb 16, 198M -under
1^71-96; submitted bv Zlanco Products Co., -1'.-. :f Ell Lilly =_-.:!
Co., Indianapolis,IN; COL:252^90-A)
C-G0186-010 Probst, G. (198^) Response to EPA Concerning Ames Test with
Oryzalin. tiipublished study supplaientlng MRID 130^27;
prepared by Lilly Research Laboratories, Greenfield, IN. 34 P-
171
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DRAFT
6560-50
ENVIRONMENTAL PROTECTION AGENCY
OFFICE OF PESTICIDES AND TOXIC SUBSTANCES
[OPP-36103;FRL ]
PESTICIDE REGISTRATION STANDARDS; AVAILABILITY FOR COMMENT
AGENCY: Environmental Protection Agency (EPA).
ACTION: Notice of Availability of draft Standard for comment
SUMMARY: This notice announces the availability of certain
draft pesticide Registration Standard documents for comment.
The Agency has completed a review of each listed pesticide
and is making available a document describing its regulatory
conclusions and actions.
DATE: Written comments on each Registration Standard should
be submitted on or before [insert date 60 days after date of
publication in the FEDERAL REGISTER].
ADDRESSES: Three copies of comments identified with the
docket number listed with each Registration Standard should
be submitted to: By mail:
Information Services Section,
Program Management and Support Division (TS-757C),
Office of pesticide Programs,
Environmental Protection Agency,
401 M St., SW.,
Washington, D.C. 20460.
85P-2132
-------
In person, deliver comments to:
Rra. 236, CM#2,
1921 Jefferson Davis Highway,
Arlington, VA.
Information submitted as a comment in response to this
notice may be claimed confidential by marking any part or all of
that information as "Confidential Business Information" (CBI).
Information so marked will not be disclosed except in accor-
dance with procedures set forth in 40 CFR Part 2. A copy of
the comment that does not contain CBI must be submitted for
inclusion in the public docket. Information not marked confi-
dential will be included in the public docket without prior
notice. The public docket will be available for public
inspection in Rm. 236 at the address given above, from 8 a.m.
to 4 p.m., Monday through Friday, excluding legal holidays.
FOR FURTHER INFORMATION CONTACT: To request a copy of a
Registration Standard, contact Frances Mann of the information
Services Section, in Rm. 236 at the address given above
(703-557-3262). Requests should be submitted no later than
[insert date 30 days after date of publication in FEDERAL
REGISTER] to allow sufficient time for receipt before the
close of the comment period.
For technical questions related to each Registration
Standard, contact the Product Manager listed for that
Standard, at the phone number given.
-------
-3-
SUPPLEMENTARY INFORMATION: The Environmental Protection
Agency conducts a systematic review of pesticides to determine
whether they meet the criteria for continued registration
under section 3(c)(5) of the Federal Insecticide, Fungicide,
and Rodenticide Act (FIFRA). That review culminates in the
issuance of a Registration Standard, a document describing
the Agency's regulatory conclusions and positions on the
continued registrability of the pesticide. In accordance
with 40 CFR 155.34(c), published in the FEDERAL REGISTER on
November 27, 1985 (50 FR 48998), before issuing certain
Registration Standards, the Agency makes the draft document
available for public comment.
Draft Registration Standards for the following pesticides
are now available:
Name of pesticide Docket number Contact person
1. Acephate 30560-19-1 William H. Miller
Product Manager 16
(703-557-2600)
2. Amitraz 33089-61-1 Jay Ellenberger
Product Manager 12
(703-557-2386)
3. Chlordimeform 6164-98-3 Jay Ellenberger
4. Copper sulfate 1344-73-6 Richard Mountfort
Product Manager 23
(703-557-1830)
5. Oryzalin 19044-88-3 Robert Taylor
Product Manager 25
(703-557-1800)
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-4-
Copies of each Registration Standard may be obtained from
the Agency at the address listed under For Further Information
Contact. Because of the length of each Standard and the
limited number of copies available for distribution, only
one copy can be provided by mail to any one individual or
organization. Each Registration Standard is also available
for inspection and copying in EPA Regional Offices at the
addresses listed below after [insert date 30 days after date
of publication in the FEDERAL REGISTER].
LIST OF EPA REGIONAL OFFICES
Pesticides Branch
EPA - Region I
JFK Federal Building
Boston, MA 02203 _
Contact person: flarontd Kaziuaitfr— 3nc
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Toxic Materials Branch
EPA - Region V
230 South Dearborn St.
Chicago, IL 60604
Contact person: Lavarre Uhlken
Pesticide and Toxic Substances Branch
EPA - Region VI
1201 Elm St.
Dallas, TX 75270
Contact person: Norman Dyer
Pesticide and Toxic Substances Branch
EPA - Region VII
324 East llth St.
Kansas City, MO 64106
Contact person: Leo Alderman
Toxic Substances Branch
EPA - Region VIII
1860 Lincoln St., Suite 900
Denver, CO 80295
Contact person: -Sob Harding- T}£/
Hazardous Materials Branch
EPA - Region IX
215 Fremont St.
San Francisco, CA 94105
Contact person: Efanoy Frost — - i
Air & Water Division
EPA - Region X
1200 6th Ave.
Seattle, WA 981.01
Contact person: Lyn F rand son C-ftucK. Shenf\
Dated:
Director,
Office of Pesticide programs
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