Brandt
    RAB/ECAD
May 2, 1991
   RAB PR£  RM1  PRESENTATION FOR C9 AROMATIC HYDROCARBON FRACTION


 SUMMARY:    There  are  no  data on  exposures to  the  C9  aromatic
 hydrocarbon fraction.   However,  based on exposure modeling using
 1,2,4-Trimethylbenzene  (1,2,4-TMB),  a major component of  the C9
 fraction,  there may be health  risks to  consumers  using solvent
 based furniture polish /varnishes  composed of 50%  C9  fraction.
 Workers may also  be at risk during manufacturing, processing and
 use of the  C9 fraction.  Based on TRI data for 1,2,4-TMB there may
 be a risk to aquatic organisms from releases  from one manufacturing
 site.  The major human health hazard concerns are  reproductive and
 developmental toxicity effects.
 I.  CHEMICAL/PHYSICAL CHARACTERISTICS
 Structure:
CS,
                         R- CH. or  R
                         X-2       X
1,2,3- TMB  (Hemimellitene)
1,3,5- TMB  (Mesitylene)
1,2,4- TMB  (Pseudocumene)
TMB  (mixed  isomers)
o-Ethyltoluene
m-Ethyltoluen«
p-Ethyltoluen«
           CAS  Nos.

              526-73-8
              108-67-8
               95-63-6
            25551-13-7
              611-14-3
              620-14-4
              622-96-8
   vp
(mm HG at
  25°C)

   1.55
   1.55
   2.1

   2.5
   2.99
   3.01
               Typical %
             by weight in
              C9 fraction

                 8.2
                 7.6
                41.3

                 9.1
                17.4
                 8.6
Ethyltoluene  (mixed isomers)25550-14-5

(D.  Bushman, 1991)

     The  C9  aromatic fraction  is  obtained  from  the  catalytic
reforming  of crude petroleum.   The major  components  of the  C9
fraction ar«  th« mixed ethyltoluen«  (ET)  (ortho-,  meta- and  para-
ET)  and trim*thyIbenzene  (1,2,3,  1,3,5-  and 1,2,4-TMB)  isomers
which have the same molecular weight of 120.2, boil over a narrow
range and  are similar in chemical  and biological  properties.   A
small  percentage  of  other  compounds  mak« up  the  rest of  the
fraction (Bushman, 1991,  pp.1-8). ET and TMB are colorless liquids
at room temperature,  readily soluble in most organic solvents and
relatively insoluble  in water.
II.  BACKGROUND/SELECTION  RATIONAL

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     The Tenth  Report  of  the  Interagency  Testing committee  (ITC)
 (47  FR  22585,  May  25,  1982)  designated ET  and 1,2,4-TMB  for
 priority  consideration  for  environmental  and  health  effects
 testing.  In its Eleventh Report (47 FR 54624,  December 3,  1982),
 the  ITC recommended that the other TMB isomers (1,2,3-and l,3,rj-)
 also be considered for testing.  The testing recommendations were
 based on the exposure  potential  of  the  chemicals and the lack of
 sufficient  information  on  environmental  and  health  effects.
 Subsequently, the Environmental Protection Agency  (EPA) promulgated
 a  final  Phase  I rule  on May  17,  1985 (50  FR 20662) in 40  CFR
 799.2175, requiring testing of the C9 aromatic hydrocarbon fraction
 (C9  fraction), which contains ET and TMB as its major components.
 On January 23,  1987  a  Phase II  rule (52 FR 2522) was promulgated
 issuing final test standards and reporting  requirements.  Modifica-
 tions to the rule were made on June 29, 1989 (54 FR 27352).

     EPA  found   (l)  production  and  use of  the  C9  fraction  was
 substantial as  a solvent  and  as a  component in  motor fuels;  (2)
 widespread exposure  exists;  (3)  existing data are inadequate to
 predict the effects  of exposure;  and (4)  testing was required to
 assess the potential of the C9 fraction to  cause adverse health and
 environmental effects.

     Section 4  test  data  and  evaluations  of the  C9 fraction were
 reviewed and commented on by  the Health and Environmental Review
 Division (HERD)  of OTS to assess the adequacy of the data for use
 in risk assessment.   Subchronic/chronic  toxicity  tests, metabolism
 studies and environmental fate and effects tests  were  not required
 because  sufficient  data  existed  (FR 20663-20664, May  17,  1985;
 McCormack, 1990, p.2).


 III. FINDINGS AND CONCLUSIONS

     A.  PRODUCTION/USB.  The 1985 estimate of production volume
 for C9 fraction  solvents was 379  million pounds/year  (Rawie, 1991,
 pp. 1-2).  The total C9 fraction manufactured is  produced by fewer
 than 200 facilities  (including 190  petroleum refineries), with an
annual production of 77,729 million pounds.  The primary manufac-
turing process is petroleum refining  (Pederson,  1991, p.l).

     The primary use of the  C9 fraction, 99.448%  of the production
volume, is as a gasoline additive.  C9  fraction  solvents are  used
 in coatings,  cleaners,  other chemicals and pesticides, printing and
 inks and  other  miscellaneous  uses (Pederson,  1991,  p.2).    Data
 representing 80% of domestic production  of C9  fraction solvents
 showed a median ET/TMB content of 80%, with a range of 75 -90% (FR
 20673, May 17,  1985).  A wide range of  solvents  also exists which
 are adequate substitutes for C9  solvents  (Rawie,  1991,  p.6).

     B.  ENVIRONMENTAL RELEASES.  The C9 fraction is  released  to
 the environment in substantial quantities through its use in motor

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 fuels  and solvents.  only  one component (1,2,4-TMB) is  a Toxic
 Release  Inventory  (TRI) chemical  (Pederson,  1991, p.l).

     C.   ENVIRONMENTAL FATE.  Most released ET and 1MB partitions
 to  the atmosphere.

     D.  EXPOSURES,  (a) Occupational;  Exposure to the C9 fraction
 is  from  dermal contact with, or inhalation of, vapors.

     (1)  Manufacturing -  There are  no data  on worker exposure to
 the  C9  fraction  during manufacturing.   However,  using toluene in
 the  petroleum refinery  industry  as  a  reference, less  than  600
 workers  would potentially be  exposed  to the C9  fraction  in  the
 petroleum refinery industry.   Petroleum refining is the primary
 manufacturing process  of the C9  fraction  (Pederson, 1991, p.l).
 Using OSHA monitoring data  (4-84 to 4-83) on toluene exposures in
 certain manufacturing and processing industries,  inferences can be
 made as  to exposures to the C9 fraction in those  same industries.
 In general, worker  exposures to toluene, and by  inference, to the
 C9 fraction,  can be expected to be relatively  low.  [This is based
 on the OSHA data  on toluene  indicating that from 87-100%  of the air
 samples   taken   from  the  following  manufacturing  industries:
 petroleum refining,  plastics materials  and  resins,  cyclic crudes
 and intermediates,  and industrial organic chemicals, were less than
 %  the  toluene  Permissible  Exposure  Level   (PEL)  of  200  ppm.]
 Exposures to  the C9 fraction can be  expected to be less  than those
 from toluene  due to the C9  fraction's lower volatility.

     (2)  Processing - There are no data on worker exposure to the
 C9 fraction or to TMB during processing (Pederson, 1991, pp. 2,9).
 Using the same train of thinking as  above, the worker exposures to
 the C9 fraction during processing  can be expected to  be  relatively
 low.   [This  is based on  the OSHA  data on toluene indicating that
 from 87-97% of the air  samples  taken from the  following  processing
 industries  — plastics materials and resins,  paints  and allied
 products, and cyclic crudes and intermediates — were less than  S
 the PEL.]

     (3)  Use  -  There are  no  data  on worker exposure  to the C9
 fraction during industrial use.  OSHA exposure monitoring  data on
TMB for workers using C9  fraction solvents are  incomplete.

     There are no data on household  worker exposure to C9  fraction
 solvents used for cleaning  and polishing furniture,  etc.

     (b)  General  Population.     There  are  no  data  on  general
population exposure to  the C9 fraction  from  either air or water
 release.   Estimates of worst case inhalation  exposure modeling  to
 1,2,4-TMB, based on the  Toxic Release  Inventory (TRI) data  for
populations near 10 air release sites, ranged from 1  to  14 tag/day,
with a median of 3  mg/day.   The two highest levels  were  14 and  6
mg/day (Lynch, 1991, p.3).

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     Estimates  of  exposure  to  1,2,4-TMB by  ingestion of  con-
 taminated drinking water (DW)  and contaminated  fish  (FI) were made
 at  3 sites with the following results (Lynch, 1991,  p.4):

          DW  (ua/yr)                    FI fua/yr)
            12.5                          46.1
            12                            44.25
            2.03                           7.49

     (c) Consumer.  No data on levels of consumer exposure to the
 C9  fraction are available.  Estimated exposures to 1,2,4-TMB have
 been calculated assuming that the chemical is used as a solvent or
 vehicle in consumer paints or solvent-based varnishes at a concen-
 tration of 50%.   Exposures via  dermal contact  (D) and inhalation
 (I) are estimated below  (Lynch, 1991, p. 5):

 Consumer Product           Route of            Exposure
                           Exposure     fmcr/yrl   fm,g/per event)

 Solvent-based Varnish         D       1.06 x 104     1330
 Aerosol Spray Paint           D       5.60 x 102      560
 Aerosol Furniture Polish      I       4.01 x 104      308
 Solvent-based Varnish         I       7.09 x 102       89
 Aerosol Spray Paint           I       1.50 x 10*       15

 For purposes of risk assessment, dermal absorption is calculated at
 10% of exposure; inhalation is calculated at 100%.

     (d)  Environmental.     The  estimated K   values of  TMB  are
 indicative of moderate mobility in soil (US EPA,  1987, p. 3).   The
concern has been  in the  release of TMB to landfills and possible
 leaching out of the  material.  A rule, however,  banning releases of
TMB  to landfills  was  promulgated  under  RCRA,  1990   (personal
communication with Dave Lynch, April  11,  1991) .

     Surface water concentrations resulting from the  discharges and
annual exposure to  1,2,4-TMB  are estimated below for three  sites
 (Lynch, 1991, p.4) :

     Mean flow                Low  flow
    fug/ 11  (ppm)            fua/11
    17.1    0.017            263      0.26
    16.43   0.016             15.66   0.015
     2.78   0.002             21.66   0.02

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      B.  HAZARDS.  The toxicity of the C9 fraction is assessed here
 as a complete entity rather than by its component chemicals. The C9
 fraction test  substance was required to have a minimum ET content
 of  22%,  a minimum  TMB content  of 15%, and  minimum  total ET/TMB
 content  of 75%.  (Page 1 shows the  composition of a  typical C9
 fraction.)   The health effects of concern  are as follows (HERD,
 1991, p.l):

 Reproductive
  LOEL:  100 mg/kg/day (100 ppm/inhalation/rat)

 Developmental
  LOEL:  210 mg/kg/day (100 ppm/inhalation/mouse)
  NOEL  (Maternal Tox.):  210 mg/kg/day  (100 ppm/inhal/mouse)
  LOEL  (Maternal Tox.): 1100 mg/kg/day  (500 ppm/inhal/mouse)
 Aquatic
  Acute IC50  (daphnid) :
  Acute EC50  (algae) :

  16-day ECSO  (daphnid)
1.44 mg/1 (ppm)
0.84 mg/1 (ppm)
1.08 mg/1 (ppm)
0.18 mg/1 (ppo)
(TMB)
(ET)
(both TMB and ET)
     Human Health Observations - Of 27 workers who had worked  for
several years with a solvent  (Fleet-X-DV99) containing 30%  1,3,5-
TMB, 50% 1,2,4-TMB and other hydrocarbons (1,2,2-TMB  and  1-methyl-
4-ethylbenzene) some experienced nervousness,  tension,  anxiety  ajid
asthmatic bronchitis, as well as  hematologic effects  (ACGIH  TLV's.
4th ED & Suppl.  1980, p. 416, IN HSDB,  Pseudocumene; US  EPA,  1987).

     Developmental/Reproductive Toxicity. A C9 fraction inhalation
developmental toxicity study in mice established a LOEL of 100  ppm
(210 mg/kg/day) (Campbell, 1989,  Conclusions).  No NOEL was  estab-
lished.  The maternal toxicity LOEL is 500 ppm (1100  mg/kg/day);  a
probable maternal toxicity NOEL is 100 ppm (210 mg/kg/day)   (Camp-
bell, 1989 IN HERD, 1991, p.3).

     A 3-generation  C9  fraction  inhalation reproductive  study  in
rats showed evidence of parental  and developmental toxicity  at  all
doses (100,  500 and 1500 mg/kg/day).  The LOEL is 100  mg/kg/day; no
NOEL was established (Seed, 1989 IN HERD,  1991,  p.2).

     Neurotoxieity.  Adult  male  rats exposed by  inhalation to C9
fraction concentrations  of  0, 100, 500  or 1500 ppm (100,  500  or
1500 mg/kg/day) for  13  weeks showed a decrease  in body  weight by
13%, after the  first week,  observed in the high-dose  group only.
No  signs  of  neurotoxicity  were  evident,  as  evaluated  by motor
activity, startle  response,  forelimb and hindlimb grip  strength,
hindlimb splay and thermal responses (McCormack, 1990,  p.11; Rees,
1989 IN HERD, 1991, p.4).

     A variety  of neur©behavioral effects were observed  in  the
developmental study with mice  following  C9  fraction  inhalation of

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 1500  ppm  (3200  mg/kg/day).   The LOEL for neurobehavioral effects
 was established at 1500 ppm.   The NOEL equaled 500 ppm (Rees,  1989
 IN HERD,  1991, p.4) .

      Mutagenicity.  The C9 fraction does  not induce gene mutations
 in prokaryotes or in mammalian cells in culture.   It does not cause
 chromosomal aberrations in mammalian cells in vitro or in vivo or
 DNA effects in mammalian cells  (Cimino, 1988 IN HERD, 1991, p.5) .
 These negative results of the mutagenicity studies did not trigger
 any   additional  mutagenicity  or  carcinogenicity   testing,,  as
 specified in the C9 test rule (Cimino, 1988).

      There  are  a  lack of carcinogenicity  test data  on  the C9
 fraction  (US EPA, 1986 IN US EPA, 1987, p.7).

      Acute, subchronic and other Toxicity.

      Animal Data - No acute toxicity data are  available  for tha C9
 fraction as a whole.   The para-ET (p-ET)  and 1,2,4-TMB isomers are
 the best characterized constituent chemicals.  Both have low acute
 toxicity.

      - Four out of 16 rats died  of  respiratory failure during a
 single continuous  24-hour  exposure  to 2400  ppm 1,3,5-TMB  (ACGIH,
 TLV's 3rd Ed and Suppl 1971-1979, p.269, IN HSDB, Mesitylene).

      Inhalation  exposure to  rats of  979  ppm  p-BT, 6  hr/day 5
 days/wk  for 13  weeks resulted  in liver enlargement.     Gavage
 administration of 400  or  800 mg/kg/day for 14 days also resulted in
 liver enlargement  (McCormack, 1990, p.4).

     Rats exposed by  inhalation to tha TMB  (3-isomer)  mixture at
 1700 ppra for 10-21 days had no adverse effects  in rats.  Exposure
 for 4 months  to the  same  concentration  caused  diminished weight
 gain and a progressive increase  in lymphopenia and neutrophil  with
 a marked depression of the central nervous  system (OP. cit.  HSDB
 Pseudocumene).

     Ecotoxicity.  The calculated log P values  on TMB and ET are
 4.1 and 4.0, respectively.   Both values suggest a high  potential
 for  accumulation  of  these  substances  in  aquatic   organisms.
Calculated acute aquatic toxicities include (HERD, 1991, p.6):

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                                    rma/1)
      96-hr LC50 (fish):         10.9   (both ET and TMB isomers)
      48-hr IC50 (daphnid) :       1.44  (both ET and TMB isomers)
      96-hr EC50 (algae):         0.84  (TMB)
                                1.08  (ET-)
      16-day EC.0 (daphnid):      0.18  (both ET and TMB isomers)
      Chronic algal  toxic ity:    0.24  (TMB)
                                0.34  ppm  (ET)

      Calculated acute daphnid and acute algal  values  indicate a
 moderate to high acute toxicity for both groups  of  isomers.  Acute
 testing  using daphnids and  algae would be  necessary  to confirm
 these estimates of  toxicity.   Calculated chronic values suggest a
 low chronic toxicity for both groups of isomers  (HERD,  1991, p. 6).

      F. RISKS.

        Possible risks to consumers  from use of aerosol furniture
        polish.

        Possible risks to workers- during manufacturing, process-
       ing,  and during use of  C9  as  an industrial  solvent and as
       a household  end product.

        Possible risks to aquatic organisms  from one release  site.

 IV.   REGULATION

      The current PEL  for individual  isomers or mixtures of TMB  is
 25 ppm (125 mg/m3) ,  with a STEL of 35 ppm (170 mg/m3).


 V.  DISCUSSION

      (a)   Consumer.   Health risks to consumers may  result  from the
 inhalation  of  vapors  and/or  from   dermal  absorption  of  the  C9
 fraction  solvent end products.    Using a  worst  case  exposure
 scenario of consumer inhalation  exposure to vapors from aerosol
 furniture polish, the MOEs from the LOELs for reproductive toxicity
 (100  mg/kg/da)  and  for developmental toxicity (210 mg/kg/da)  from
 animal  studies  would be  17  and  35, respectively.    Risks  to
 consumers   from combined  dermal and  inhalation exposures   to
 furniture varnish would also give low MOE's (22,  and 48  respective-
 ly) .   Since the modeling  is  based on worst  case assumptions,
 including  polishing furniture every 3 days,  the risks would  not
 necessarily be to  the  average  consumer.    However,  using  these
 assumptions  there may be risks to persons who clean households  as
 a profession,  (see  occupational  section).
     Another possible risk to consumers may be from exposure to the
C9 fraction when pumping  gasoline.   This concern  is addressed  in
 "SECTION 4  ISSUES"  (Section  VI.,  below).

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      (b) occupational!  There are no worker exposure data on the C9
 fraction.   However,  exposure levels  to  toluene  in  similar indus-
 tries  (including petroleum refining)  indicate  that most  worker
 exposures during manufacturing and processing would be to concen-
 trations less than k  the PEL.  This comparison with toluene is only
 a gross one since the PEL for toluene is 200 ppm, and that for TMB,
 the major component of the  C9 fraction,  is  25 ppm.  However, since
 toluene is more volatile than the C9 fraction,  a gross comparison
 is possible.

     If C9  fraction  exposures  were similar  to  those  of  toluene,
 i.e.,  most of the exposures were < ** PEL for TMB (< % of 25 ppm),
 workers would be exposed below the LOELs for reproductive and
 developmental toxicities from animal studies (100 mg/kg/da, and 210
 mg/kg/da, respectively).  However, there would still be a concern
 for reproductive and  developmental toxicities risk since the margin
 of exposure from these LOELs would be 8 and 16, respectively.  [210
 mg/kg/da (Developmental LOEL)  * 13 mg/kg/da; and 100 mg/kg/da
 (Reproductive LOEL) +  13 mg/kg/da.] (*Sea calculations below.)

     OSHA data on worker exposure to TMB during use as an industri-
 al solvent  is  incomplete.   It  indicates that about 8% of samples
 taken were  less than  the  detection  level.  OSHA data  on worker
 exposures to toluene to the same Standard Industrial Codes (SICs)
 for  industrial use  indicate  that  some exposures are  >  ^  PEL.
 Therefore,   there  may  also be a  concern  for  reproductive  and
 developmental toxicity  risk due to industrial solvent exposures.

     There is no data on exposure  to the C 9  fraction as a solvent
 in end  products during use by professional household cleaners.
 There may be a health risk  to these persons who  usa these products
 on a daily basis  (see discussion in consumer section).

     (c) General  Population.   There  are no data  on  C9 friction
 releases to air.    However,  an  estimate  of   the  C 9  fraction
 exposures can be made using TRI data on 1,2,4-TMB.   The TRI data
does not tell us if the C9  fraction was  released from these sites,
and only 1,2,4-TMB was measured, or if only 1,2,4-TMB was released.
However,  it  is known that  1,2,4-TMB  is used  primarily  as a
component of the C9 fraction.  If the 1,2,4-TMB data can be used as
a measure  of exposure expected from  the C9 fraction,  then  the
margin of exposures (MOE) from the LOEL (lOOmg/kg/da)  for reproduc-
tive toxicity  from an animal study would be 357 and 833,  respec-
tively  for  the  two  sites with  greatest  releases  of 1,2,4-TMB.
These MOEs indicate that the expected exposures would be well below
the LOELs from  the animal  study.   Given that the modeling of  the
TRI data uses worst case assumptions, there  does not appear to be
a health risk to the general population from air releases.

     Exposure to contaminated drinking water and contaminated  fish
present no risk, since the estimated levels are  below the level of
concern.

                                8

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        (d) Environmental.   There is a concern for potential risk
 to aquatic organisms during low flow conditions at a Lancaster PA
 site.  Surface water  low  flow  concentrations  based on TRI data on
 1,2,4-TMB were above a chronic effect level for daphnids.

 *[TMB  PEL=»  25  ppm or I25mg/m3;  I25mg/m3 X  I,25m3/hr  X  8  hr day =
 1250 mg/da exposure.   Divide by a 50 kg person - 25 rag/kg/da; \ the
 TMB PEL - 13 mg/kg/da]


 VI.  SECTION 4 ISSUES

     Although EPA recognized  that  there may  be substantial human
 exposure to gasoline and its component hydrocarbons,  including the
 C9  fraction,  the  Agency did not  consider   exposure to  the C9
 fraction in gasoline as part of its basis for finding substantial
 human  exposure to the C9 fraction (50 FR  20664,  May 17, 1985).
 EPA justifies its decision by indicating that the C9 fraction was
 among  approximately  300  chemical  species  in  gasoline  and  the
 concentrations  in a  typical  motor  gasoline are  relatively  low
 (approximately 3%) .   Also, since  existing  data  showed unleaded
 gasoline  to  be  carcinogenic  in  laboratory  animal  inhalation
 studies, exposure controls for gasoline were expected to be based
 on  these data  or on additional  testing of  gasoline  aimed at
 characterizing its overall toxicity as a complex product.   Data on
 the C9 fraction alone would be of minimal relevance to that overall
 determination (50 FR 20666, May 17, 1985).


 VII.  OTHER ISSUES

     EPA currently has a Petroleum Cluster Policy group.  An RM1
 meeting is scheduled  for May  1, 1991.


VIII.  RECOMMENDATIONS

     1.  Notify  CPSC of the  possible  risks  to consumers  from C9
 fraction solvent  end products and  the need  for exposure informa-
 tion.

     2.  Bring information   to the attention of  OSHA, NIOSH,  and
ACGIH  indicating the need  for exposure  information to verify  a
 possible risk to  workers from the  C9 fraction.

     3.  Give information to appropriate EPA Regions to communicate
 to the industrial site a possible  aquatic  toxicity concern.

     4.  Send copy of RM1 information  to  Petroleum Cluster Policy
Group.

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 IX. REFERENCES

 Bushman, Daniel R.  January, 1991.  RMl Industrial Chemicals Branch
      (ICB) Form.
 Cimino, M.  April 1,  1988.   Review of  Mutagenicity Testing Results
     on  C9 Aromatic  Hydrocarbon Fraction.   Memorandum  from P.
     Fenner-Crisp, Health and Environmental Review Division (HERD)
     to R. Troast, Test Rules Development Branch, Existing Chemical
     Assessment Division (ECAD).  Washington, DC:  OTS, US EPA.
 HERD.  February 1991.  HERD (Health and Environmental Review
     Division) Profile Working Draft, C9 Aromatic Hydrocarbons.
 HSDS.  Mesitylene.  Hazardous Substance Databank.
     -Pseudocumene.
 Lynch, David G.  April  2, 1991.  Preliminary Exposure Assessment for
     C-9 Hydrocarbons.  Memorandum from David G.  Lynch, Exposure
     Assessment Branch  (EAB) ,  to Ethe], Brandt,  Existing Chemical
     Assessment Division (ECAD).
McCormack, K., P. Wirdzek, R. Troast, R. Nelson, N. Chandhari and
     Merrifield.  9/6/90.    Summary  of  C9  Aromatic  Hydrocarbon
     Fraction:  Ethyltoluenes, and Trimethylbenzenes.
Pederson, Mark E.  March 7, 1991.  RMl Initial Chemical Engineering
     Branch (CEB) Summary, Aromatic C9 Hydrocarbons.
Rawie, Carol.  Feb. 20, 1991.  RMl Economic  Analysis for C-9
     Hydrocarbons. Memorandum from Carol Rawie,  Regulatory Impacts
     Branch  (RIB),  Economics  and Technology Division  (ETD), to
     Ethel Brandt, Existing Chemical  Assessment Division  (ECAD):
Rees,  D.  Cooper.  1989.  Section 4 Testing of  C9  Aromatic Hydrocar-
     bons:  Neurotoxicity data.   Memorandum from  C.  Rees, Toxic
     Effects  Branch  (TEB),  to C.  Auer,  Health and Environmental
     Review Division  (HERD).  Washington,  DC:  OTS:  USEPA.
U.S. Environmental Protection Agency.  June,  1987.  Office of
     Research and Development  (ORD),  Office  of Health and
     Environmental Assessment  (OHEA), Environmental Criteria and
     Assessment  Office  (ECAO),   "Health  Effects  Assessment  for
     Trimethylbenzenes11.
                                10

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                       RM1 Meeting Summary

                                                  Final 8/28/91/CG

Date:  May 22, 1991
Subject:  C-9 Aromatics
Chairman:  Jim Willis
Coordinator:  Ethel Brandt
Supporting Documents: Briefing paper

Background Information:

     The  C9  aromatic hydrocarbon  fraction is  obtained from the
catalytic reforming of crude  petroleum.   The Interagency. Testing
Committee recommended that C9  fraction be tested under Section 4 of
TSCA, based on the  exposure potential  and the lack of  sufficient
information on environmental and health effects.

     77,729 million pounds/yr of C9 fraction  are  produced.   The
primary use of this volume is as a gasoline additive.   Other uses
include use as a solvent  in coatings, cleaners,  other  chemical and
pesticides, printing and  inks  and other miscellaneous uses.  A wide
range of substitutes exists for C9 solvents.

     Releases  of C9  fraction to  the environment  occur  to the
atmosphere (via stack and fugitive  emissions, and evaporation from
spills), to water, and to soil (via landfill waste).

     There are no data on worker exposure to C9 fractions during
manufacture, processing,  or use, nor is there any data  available on
household worker exposure, general population exposure, or consumer
exposure to C9 fractions.  Worker exposures can be estimated using
toluene as a reference.  The estimated exposures during manufacture
and processing are low.

     Surface water concentrations resulting from the discharges and
annual exposure to 1,2,4-Trimethylbenzene  have  been estimated, and
are listed in the briefing paper.

     The  toxicity  of the  C9  fraction as a complete entity was
assessed  by  HERD,  and the concerns are  listed in  the briefing
paper, along with LOELs and NOELs.  In general, concerns were for
reproductive and developmental toxicity,  as well as a moderate to
high acute toxicity to aquatic organisms,  and low chronic toxicity
to aquatic organisms.

     There is a possible  risk  to  consumers from the use  of aerosol
furniture polish.  Workers could be at risk during manufacturing,
processing  and use  of  C9  as  an industrial   solvent  and  as  a
household product.  Risks to  aquatic organisms are possible from
one release site.

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Page 2
C-9 Aromatics
8/28/91


Discussion:

     There has been no verification that C-9 fraction is actually
found in any consumer products.  It was therefore decided that such
verification should be the  first  order  of  business.   However,  it
does not seem, prudent to spend  a  great  deal of resources on such
verification. ETD will perform a limited survey of manufacturers.
If  no  information  can  be  easily obtained, the  search will  be
discontinued.  If it can be verified  that  the  C-9 fraction is in
consumer products,  then  a  letter  of  concern will be  written  to
producers,  as well  as to CPSC,  based on  the  ethylhexanoic acid
model.   This letter  will notify  producers and CPSC of the possible
risk to  consumers from  C9  fraction solvent end products and the
need for exposure information.

     The information will  also be  given  to the  appropriate EPA
Region for communication of a possible concern for aquatic toxicity
for the industrial site.

     The RM1 information packet  will be  sent to the Petroleum
Cluster Policy Group,  as well as the Indoor Air Cluster Group.

     With  the exception of the  above  mentioned activities and
referrals,  C9 Aromatic Hydrocarbons will be dropped  from further
RM1 review.

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