TECHNICAL BACKGROUND DOCUMENT
TO SUPPORT RULEMAKING
PURSUANT TO CERCLA SECTION 102
VOLUME 3
(PROPOSED RULEMAKING)
A Report to
RELEASES CONTROL BRANCH
OFFICE OF RESEARCH AND DEVELOPMENT
And to
EMERGENCY RESPONSE DIVISION
OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
U.S. ENVIRONMENTAL PROTECTION AGENCY
Under
Contract No. 68-03-3182
Prepared by
ENVIRONMENTAL MONITORING & SERVICES, INC.
A WHOLLY OWNED SUBSIDIARY OF COMBUSTION ENGINEERING, INC.
FORMERLY ENVIRONMENTAL MONITORING & SERVICES CENTER
OF ROCKWELL INTERNATIONAL CORPORATION
NEWBURY PARK, CALIFORNIA 91320
March 1985
DRAFT
DO NOT CITE OR QUOTE
-------
TECHNICAL BACKGROUND DOCUMENT
TO SUPPORT RULEMAKING
PURSUANT TO CERCLA SECTION 102
VOLUME 3
(PROPOSED RULEMAKING)
A Report to
RELEASES CONTROL BRANCH
OFFICE OF RESEARCH AND DEVELOPMENT
And to
EMERGENCY RESPONSE DIVISION
OFFICE OF SOLID WASTE AND EMERGENCY RESPONSE
U.S. ENVIRONMENTAL PROTECTION AGENCY
Under
Contract No. 68-03-3182
Prepared by
ENVIRONMENTAL MONITORING & SERVICES, INC.
A WHOLLY OWNED SUBSIDIARY OF COMBUSTION ENGINEERING, INC.
FORMERLY ENVIRONMENTAL MONITORING & SERVICES CENTER
OF ROCKWELL INTERNATIONAL CORPORATION
NEWBURY PARK, CALIFORNIA 91320
March 1985
-------
DISCLAIMER
This document has not been peer and administratively reviewed within EPA and
is for internal Agency use and distribution only. This report is being issued
as an internal draft for discussion purposes only.
-------
FOREWORD
This draft report was submitted to the Releases Control Branch (formerly the
Oil and Hazardous Materials Spills Branch), Office of Research and
Development, Edison, New Jersey, and the Emergency Response Division of the
Office of Emergency and Remedial Response, of the Office of Solid Waste and
Emergency Response, of the U.S. Environmental Protection Agency (EPA) to
provide the technical base for adjustment of reportable quantities (RQs) for
an additional group of the hazardous substances defined in CERCLA Section
101(14) and for which no adjusted RQs are listed in the current Final Rule or
in the companion Notice of Proposed Rulemaking ( NPRM). It was prepared by
the technical staff of Environmental Monitoring & Services, Inc. (EMSI), a
wholly owned subsidiary of Combustion Engineering, and formerly the
Environmental Monitoring and Services Center of Rockwell International
Corporation. Principal authors are Mr. Franz J. Burmann, Dr. Frank
C. Gunderloy, Jr., Dr. Milton Kirsch, and Mr. Greg Ricci.
The guidance of many members of the EPA staff was provided not only in a
continuous fashion, but also in special working group meetings and by written
and oral comments on the various drafts. The assistance of Dr. K. Jack
Kooyoomjian, Mr. John Riley, and Mr. Richard Horner of the Emergency Response
Division was especially helpful.
The EPA project officer during most of the project was the late Mr. Leo
T. McCarthy, Jr., of the Releases Control Branch, Edison, New Jersey, who
provided invaluable guidance during the project. Recently, his place has been
ably taken by Mr. Richard Field. The support and helpful suggestions of
Mr. James Janis, Mr. Michael Goldman, Mr. Jim Bunting and other staff members
of ICF, Inc., subcontractor to Environmental Monitoring and Services, Inc.,
are acknowledged.
iii
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CONTENTS
PAGE
Foreword iii
Executive Summary ES-1
Section 1. Introduction 1-1
Method of Adjustment 1-1
Summary of Adjustments. 1-2
F- and K- Waste Streams 1-3
Unlisted Hazardous Wastes 1-4
Organization of Report 1-4
Section 2. Proposed RQ Adjustments and Assignments 2-1
Methodology for RQ Adjustments 2-1
Other Factors 2-28
Status of Hazardous Substances Designated
Under the CWA Section 311 2-31
RQs for the F- and K- Hazardous Waste
Streams 2-31
RQs for Unlisted Hazardous Wastes 2-32
RQs Based on Potential
Carcinogenicity Rankings 2-33
Identification of Chemical Carcinogens
on the CERCLA Section 101(14)
List 2-34
CAG's Ranking Methodology For Potential
Carcinogens 2-36
Results of the Carcinogenicity
Ranking 2-38
Substances Not Identified as
Carcinogens 2-40
Substances Only Qualitatively
Identified As Carcinogens .... 2-41
Known Carcinogen Not Rankable by CAG
Methodology 2-41
Indirect Assignment of RQs for
Potential Carcinogens 2-41
A Comparison of Chronic Toxicity and Potential
Carcinogenicity as Primary Criteria 2-43
Section 3. Data Tables for Hazardous Substances 3-1
v
-------
CONTENTS (Continued)
PAGE
Appendix A Data for Evaluation of Biodegradation, Hydrolysis
and Photolysis (BHP) A-l
Appendix B Technical Support Document and Summary Table for
the Ranking of Hazardous Chemicals Based on
Carcinogenicity B-l
Appendix C Summary Table for the Ranking of Formaldehyde,
2-Nitropropane, Selenium sulfide, Benzotrichloride,
and Bis(2-ethylhexyl) Phthalate Based on
Carcinogenicity C-l
TABLES
TABLE NO. PAGE
2-1 Hazardous Substances and Proposed Reportable
Quantity Adjustments for the Additional NPRM 2-2
2-2 Final Candidate List for Upward RQ Adjustments Based
on Other Factors (BHP) 2-30
2-3 Carcinogen Ranking Scheme 2-39
3-1 Data for the NPRM Hazardous Substances 3-3
vi
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EXECUTIVE SUMMARY
The purpose of this report is to provide the U.S. Environmental Protection
Agency (EPA) with the technical background required to adjust the reportable
quantities (RQs) of an additional 260 hazardous substances (including 69
hazardous wastes) designated in Section 101(14) of the Comprehensive
Environmental Response, Compensation, and Liability Act of 1980 ("CERCLA" or
"Superfund"), seven of which are being explicitly identified for the first
time as CERCLA hazardous substances; and to reexamine and repropose the RQ
for one hazardous substance (methyl isocyanate) for which the originally
proposed RQ was 100 pounds. Technical background on the previous RQ
adjustment of 445 hazardous substances and hazardous wastes may be found in
the documents "Technical Background Document to Support Rulemaking Pursuant to
CERCLA Section 102, Volume 1," and "Technical Background Document to Support
Rulemaking Pursuant to CERCLA Section 102, Volume 2, (Proposed Rulemaking),"
both dated March 1985.
These latter background documents provide details on the law, legislative
history, and the development of the preferred methodology for adjusting RQs.
CERCLA assigns statutory RQs to 705 hazardous substances and these RQs remain
in force until the Administrator of the EPA adjusts them. The preferred RQ
adjustment methodology first assigns primary criteria RQs on the basis of the
criteria of aquatic toxicity, mammalian toxicity (oral, dermal, and
inhalation), ignitability, reactivity, and chronic toxicity. Potential
carcinogenicity, which is also a primary criterion, is applied to most of the
260 hazardous substances for which RQs are proposed in this present background
document. The primary criteria RQ for each hazardous substance is the lowest
value of all the applicable criteria. The Agency then evaluates each
hazardous substance according to a set of other criteria consisting of
biodegradation, hydrolysis, or photolysis (BHP). The primary criteria RQ is
then raised one level if an analysis indicates that the hazardous substance
naturally degrades by BHP into less hazardous products when released into the
environment. If the degradation products are more hazardous than the parent
ES-1
-------
hazardous substance, the RQ is adjusted on the basis of the degradation
products and an upward adjustment on the basis of BHP is not made.
Summary of Adjustments
The table below summarizes the proposed RQ adjustments for the 260 hazardous
substances. The number of hazardous substances is given for each of the five
RQ categories.
No. of Hazardous Substances With Specified RQs
RQ (Pounds) Statutory RQ Proposed RQ
1 199 89
10 12 112
100 6 58
1000 25
5000 18 1
Total 260 260
The RQs proposed lower the RQs of 56 hazardous substances, raise the RQs of
131 hazardous substances and leave the RQs of 73 hazardous substances
unchanged.
ES-2
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SECTION 1
INTRODUCTION
In a final rule published in the Federal Register April 4, 1985, the
Environmental Protection Agency (the EPA or the Agency) adjusted the
reportable quantities (RQs) of 340 of the 705 CERCLA hazardous substances.
Proposed RQ adjustments for an additional 105 hazardous substances were
published in a new Notice of Proposed Rulemaking (NPRM) at the same time. The
705 CERCLA hazardous substances include 97 hazardous waste streams with RQs
adjusted as follows: 21 as part of the 340 hazardous substances in the final
rule, seven as part of the 105 hazardous substances in the new NPRM, and 69 as
part of the remaining 260 hazardous substances.
The assessments for these last 260 hazardous substances including 69 hazardous
waste streams have been completed and RQ adjustments will be proposed in an
additional NPRM. The purpose of this document is to identify the 260
hazardous substances for which RQ adjustments will be proposed and to provide
data supporting the proposed RQs. In addition, RQs are proposed for six of
the constituents used in determining the Characteristic of EP (Extraction
Procedure) Toxicity for Unlisted Hazardous Wastes.
The statutory 1-pound RQ for radionuclides will be adjusted in a future
rulemaking.
METHOD OF ADJUSTMENT
RQs are adjusted using a methodology that assigns primary criteria RQ values
based on the following intrinsic properties of each hazardous substance:
aquatic toxicity, mammalian toxicity (oral, dermal, and inhalation),
ignitability, reactivity, chronic toxicity, and potential carcinogenicity.
These primary criteria RQs can then be raised one level on the basis of other
criteria, namely the natural degradative processes of biodegradation,
1-1
-------
hydrolysis, or photolysis (BHP). However, if hazardous substances are found
to be bioaccumulative, environmentally persistent, highly reactive or
degradable to more hazardous products, they are not eligible for a one-level
RQ increase on the basis of BHP. If degradation of a hazardous substance
produces a more hazardous product, not only is an upward BHP adjustment not
made, but the RQ adjustment is based on the product rather than on the less
hazardous parent substance.
SUMMARY OF ADJUSTMENTS
The table below summarizes the proposed RQ adjustments for the 260 hazardous
substances addressed in this document. The number of hazardous substances is
given for each of the five RQ categories.
No. of Hazardous Substances
With Specified RQs
RQ (Pounds) Statutory RQ Proposed RQ
1 199 89
10 12 112
100 6 58
1000 25
5000 18 1
Total 260 260
The RQs proposed lower the RQs of 56 hazardous substances, raise the RQs of
131, and leave the RQs unchanged for 73.
Of the 191 individual hazardous substances on this list (exclusive of the 69
hazardous waste streams), 87 have been evaluated for chronic toxicity by the
Environmental Criteria and Assessment Office (ECA0) in Cincinnati, Ohio, a
branch of the EPA's Office of Health and Environmental Assessment (0HEA), and
173 of the hazardous substances have been evaluated for potential
carcinogenicity by the EPA's Carcinogen Assessment Group (CAG), which is also
1-2
-------
a part of OHEA. The 191 individual hazardous substances which were evaluated
by ECAO and CAG are identified in Table 3-1, in the column "Chronic
Toxicity/Carcinogen". The result of CAG's evaluation shows that 173 of these
individual hazardous substances are potential carcinogens, and all will be
assigned an RQ value based on CAG's methodology. (See p. 2-33 for details of
the CAG ranking methodology for potential carcinogencity.) However, in some
cases, the other primary criteria (aquatic toxicity, mammalian toxicity,
chronic toxicity, ignitability, and reactivity) result in assigning lower
final RQs to the hazardous substances than those RQs that result from the
potential carcinogenicity ranking alone. The basis for the final RQs of the
191 individual hazardous substances are as follows: 131 on the basis of
potential carcinogenicity, 13 on the basis of potential carcinogenicity and
chronic toxicity, 14 on the basis of potential carcinogenicity and at least
one other primary criterion, one on the basis of chronic toxicity, 31 on the
basis of other primary criteria and/or BHP, and one (methyl isocyanate) on the
basis of a decision by the Agency to retain the statutory RQ of one pound
pending additional studies and technical analyses of the Bhopal, India data.
F- and K- Waste Streams
RQ adjustments are being proposed for 12 of the F- list hazardous waste
streams and 57 of the K- list hazardous waste streams. The statutory RQ for
these 69 hazardous wastes is currently one pound. The proposed adjustments
leave the RQs of 25 hazardous waste streams at 1 pound, raise the RQs of 33
hazardous waste streams to 10 pounds, and 11 hazardous waste streams to
100 pounds.
1-3
-------
Unlisted Hazardous Wastes
The list of proposed RQs includes adjustments for six of the constituents used
to determine the Characteristic of EP (Extraction Procedure) Toxicity for
Unlisted Hazardous Wastes. The six constituents are arsenic, cadmium,
chromium, lead, lindane, and toxaphene.
ORGANIZATION OF REPORT
Section 2 of this document presents a table (Table 2-1) which lists the 260
hazardous substances including 69 hazardous waste streams for which adjusted
RQs will be proposed, as well as the numerical RQ for each. In addition,
Section 2 contains a brief discussion of the rationale, and the methodology
used to determine the appropriate RQ levels. Section 2 also contains a
detailed discussion of the methodology used by CAG to rank potential
carcinogens. Section 3 of this document contains the data tables supporting
the proposed RQs presented in Section 2.
1-4
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SECTION 2
PROPOSED RQ ADJUSTMENTS AND ASSIGNMENTS
Table 2-1 lists the 260 CERCLA hazardous substances for which adjusted RQs are
being proposed or reproposed (methyl lsocyanate), together with the statutory
and proposed RQ for each hazardous substance. In addition, seven waste
streams (F020, F021, F022, F023, F026, F027, and F028) are listed for the
first time as CERCLA hazardous substances. The list is arranged
alphabetically and identifies by numerical code in the Statutory Code column
the statutory source for their designation under CERCLA Section 101(14). The
codes are explained in footnotes to the table. In addition, since many
hazardous substances are regulated under more than one statute and may be
identified by different names in the different statutes, all the names under
which a hazardous substance are listed pursuant to any statute or implementing
regulation are listed alphabetically and the synonyms are included in the
Regulatory Synonyms column. Each hazardous substance is uniquely identified
by its Chemical Abstracts Service Registry Number (CASRN).
METHODOLOGY FOR RQ ADJUSTMENTS
The methodology used for adjusting RQs has been discussed in detail in the
draft report "Technical Background Document to Support Rulemaking Pursuant to
CERCLA Section 102, Volume 1," March 1985, and is summarized briefly in the
paragraphs that follow. This methodology is one with which the regulated
community is familiar and is based in part on the methodology used to
establish RQs pursuant to Section 311 of the Clean Water Act (CWA). The
methodology begins with an evaluation of the intrinsic physical, chemical, and
toxicological properties associated with each hazardous substance. The
intrinsic properties evaluated, called primary criteria, are: aquatic
toxicity, mammalian toxicity (oral, dermal, and inhalation), ignitability,
reactivity, chronic toxicity, and potential carcinogenicity. (Refer to 48 FR
pp 23552-23602 for a description of the proposed methodology.)
2-1
-------
Table 2-1
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES
1 1
1
Statutory
Hazardous Substance
1 1
1 1
I CASRN | Regulatory Synonyms
1
1
1 RCRA
I Waste
Proposed RQ
1 RQ
Code
t iNumber
Category
Pounds(Kg)
Acetaldehyde, trichloro-
1 1
I 75876 iChloral
1 |
1 1*
1
4
1
I U034
1
D
5000 (2270)
Acetamide, N-(4-ethoxyphenyl)-
1 1
I 62442 IPhenacetin
1 i
l
1 1*
i
4
1
I U187
I
B
100 (45.4)
Acetamide, N-9H-fluoren-2-yl-
I l
I 53963 |2-Acetylaminonuorene
1 i
1
1 1*
i
4
1
I U005
1
A
10 (4.54)
Acetic acid, lead salt
1 1
I 301042iLead acetate
I i
1
15000
i
1,4
1
1 U144
i
B
100 (45.4)
2-Acetylaminofluorene
i i
I 53963 lAcetamide, N-9H-fluoren-2-yl-
1 1
i
1 1*
4
1
I U005
i
A
10 (4.54)
Acrylonitnle
1 1
I 107131 |2-Propenenitn]e
i i
1
1100
i
1,2,4
1
I U009
B
100 (45.4)
Alanine, 3-lp-bis(2-chloroethyl)amino]phenyl-,L-
I I
I 148823 iMelphalan
1 1
1
1 1*
1
4
1
1 U150
i
X
1 (0.454)
Aldnn
I 309002 M^S^lO-lO-Hexachloro-l^^a^^Sa-hexahydro-
1 |l,4:5,8-endo,exo-dimethanonaphthalene
| |
i
I 1
1
I
1,2,4
i
I P004
1
j
X
1 (0.454)
Amitrole
1 1
1 61825 |lH-l#2,4-Triazol-3-amine
I j
1 1*
i
4
1 U011
1
B
100 (45.4)
Ammonium bichromate
1 1
| 7789095 1
i i
I
11000
1
1
1
1
1
A
10 (4.54)
Ammonium chromate
1 1
| 7788989 1
i i
1
11000
1
1
1
1
1
A
10 (4.54)
Aroclor 1016
1 1
112674112 |
1 |
1 10
1
1,2
1
1
1
X
1 (0.454)
Aroclor 1221
| 1
1111042821
1 1
1 10
1
1,2
1
1
1
X
1 (0.454)
Aroclor 1232
1 1
111141165 |
1 |
1
1 10
j
1,2
1
1
I
X
1 (0.454)
Aroclor 1242
1 I
1534692191
I . I
1 10
1
1,2
1
1
1
X
1 (0.454)
Aroclor 1248
1 * 1
112672296 I
1
1 10
1
1,2
1
1
1
X
1 (0.454)
Aroclor 1254
l 1
111097691 1
1
1 10
1
1,2
1
1
1
X
1 (0.454)
Aroclor 1260
1 1
111096825 1
i i
10
1
1,2
1
1
1
X
1 (0.454)
Arsenic tt
1 1
I 7440382 1
i j
\
1 1*
2,3
1
1
X
1 (0.454)
Arsenic acid
1 1
I 13275221
| 7778394 1
i t
1
1 1*
1
1
4
1
1 P010
1
X
1 (0.454)
Arsenic disulfide
1 1
I 1303328 |
I i
1
15000
1
1
1
1
X
1 (0.454)
Arsemc(lll) oxide
1 i
| 1327533 lArsenic tnoxide
1 1
15000
1
1,4
1
1 P012
1
X
1 (0.454)
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
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LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES
- Continued
1
1
Statutory
1
1
1
1
1 RCRA
1 Waste
Proposed RQ
Hazardous Substance
1 CASRN
Regulatory Synonyms
1 RQ
Code
t [Number
Catecory
Pounds(Kg)
Arsenic(V) oxide
1
1 1303282
1
Arsenic pentoxide
1
15000
1
1,4
1
I P011
I
X
1 (0.454)
Arsenic pentoxide
1
1 1303282
1
Arsenic(V) oxide
1
15000
1
1,4
1
1 P011
1
X
1 (0.454)
Arsenic trichloride
1
I 7784341
1
1
15000
I
1
i
1
X
1 (0.454)
Arsenic trioxide
1
I 1327533
i
Arsenic(IU) oxide
1
15000
|
1.4
1
1 P012
1
X
1 (0.454)
Arsenic trisulfide
1
I 1303339
i
1
15000
1
1
1
1
1
X
1 (0.454)
Arsine, diethyl-
1
1 692422
I
Diethylarsine
1
1 1*
1
4
1
I P038
1
X
1 (0.454)
Asbestos ttt
I
I 1332214
I
1
1 1*
1
2,3
1
1
i
A
10 (4.54)
Auramine
J
I 492808
1
Benzenamine, 4,4'-carbonimidoylbis (N,N-dimethyl-
1
1 1*
4
1
1 U014
i
B
100 (45.4)
Azaserine
1
1 115026
j
L-Senne, diazoacetate (ester)
1
1 1*
1
4
1
I U015
1
A
10 (4.54)
Aziridine
1 151564
i
Ethylenimine
1
1 1*
1
4
1
I P054
i
X
1 (0.454)
Azirino(2',3':3,4)pyrrolo(l,2-a)indole-4,7-dione,6-
amino-8- [((aminocarbonyDoxy)methyl]-
l,la,2,8,8a,8b-hexahydro-8a-methoxy-5-methy]-
1
I 50077
1
1
|
Mitomycin C
1
1 1*
1
1
1
4
1
I U010
1
1
1
A
10 (4.54)
Benz[j)aceanthrylene, l,2-dihydro-3-methyl-
i
1 56495
i
3-Methylcholanthrene
1 1*
t
4
1
1 U157
A
10 (4.54)
Benz[c]acndine
I 225514
I
3,4-Benzacridine
1
1 I*
1
4
1
I U016
i
A
10 (4.54)
3,4-Benzacridine
1
I 225514
l
Benz[c]acridine
1
1 1*
i
4
1
1 U016
j
A
10 (4.54)
Benz[a lanthracene
I
I 56553
j
1,2-Benzanthracene
Benzo[a]anthracene
1
1 1*
1
2,4
1
1 U018
1
A
10 (4.54)
1,2-Benzanthracene
| 56553
1
1
Benz[a]anthracene
Benzol alanthracene
1
1 1*
1
¦
2,4
1
I UQ18
1
i
A
10 (4.54)
1,2-Benzanthracene, 7,12-dimethyl-
i
I 57976
¦
7,12-Dimethylbenz[ a lanthracene
1
1 1*
4
1
I U094
¦
X
1 (0.454)
Benzenamine, 4,4'-carbonimidoylbis (N,N-di methyl-
I 492808
1
Auramine
1
1 1*
¦
4
i
I U014
i
B
100 (45.4)
Benzenamine, 4-chloro-2-methyl-, hydrochloride
1
I 3165933
i
4-Chloro-o-toluidine, hydrochloride
1
1 1*
4
1
1 U049
I
B
100 (45.4)
Benzenamine, N,N-dimethyl-4-phenylazo-
i
1 60117
i
Dimethylaminoazobenzene
1
1 1*
¦
4
1
1 U093
¦
X
1 (0.454)
Benzenamine, 4,4'-methylenebis(2-chloro-
1
1 101144
1
4,4'-Methylenebis(2-chloroaniline)
1
1 1*
1
4
1
I U158
1
B
100 (45.4)
R QLIST/CA R C0485 A.DTB/CON RQLIST. H ED/CON RQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued!
1
1
Statutor
y
1
1
1
1
1 RCRA
1 Waste
Proposed RQ
Hazardous Substance
1 CASRN
Regulatory Synonyms
1 RQ
Code t [Number
Category
Pounds(Kg)
Benzenamine, 2-methy)-, hydrochloride
1
I 636215
j
o-Toluidine hydrochloride
1 1»
j
4
I U222
B
100 (45.4)
Benzenamine, 2-methyl-5-nitro-
I 99558
j
5-N i tro-o- tol ui di ne
I
1 1*
1
4
1 U181
B
100 (45.4)
Benzene
1 71432
|
1
11000
1
1,2,3,4
1 U019
B
100 (45.4)
Benzene, chloromethyl-
1
1 100447
|
Benzyl chloride
1
1100
I
M
I P028
A
10 (4.54)
Benzene, hexachloro-
1 118741
I
Hexachlorobenzene
1
1 1*
1
2,4
1 U127
A
10 (4.54)
Benzene, l-methyl-2,4-dimtro-
1
1 121142
|
2,4-Dini trotoluene
1
11000
1
1,2,4
1 Ul 05
B
100 (45.4)
Benzene, l-methyl-2,6-dinitro-
1 606202
j
2,6-Dini trotoluene
1
11000
1
1,2,4
I U106
B
100 (45.4)
Benzene, l,2-methylenedioxy-4-allyl-
1 94597
1
Safrole
1
1 1*
1
4
I U203
B
100 (45.4)
Benzene, l,2-methylenedioxy-4-propenyl-
1
I 120581
1
Isosafrole
1
1 1*
1
4
I U141
B
100 (45.4)
Benzene, l,2-methylenedioxy-4-propyl-
i
1 94586
j
Dihydrosafrole
1 1*
1
4
1 U090
B
100 (45.4)
Benzene, pentachloronitro-
1 82688
i
Pentachloroni trobenzene
1
1 1*
1
4
I U185
B
100 (45.4)
Benzene, (trichloromethyl)-
1
I 98077
j
Benzotrichloride
1
1 1*
1
4
1 U023
A
10 (4.54)
Benzeneacetic acid, 4-chloro-alpha-(4-
c hlorophenyl >-alpha-hydroxy- ,et hyl est er
I 510156
1
j
Ethyl 4,4'-dichlorobenzilate
1
1 1*
1
1
4
I U038
B
100 (45.4)
1,2-Benzenedicarboxylic acid, [bis(2-ethylhexyl)]
ester
1 117817
1
1
Bis (2-ethylhexyl) phthalate
1
1 1*
1
1
2,4
I U028
B
100 (45.4)
Benzidine
1
1 92875
(l,r-Biphenyl)-4,4'diamine
1
1 I*
j
2,4
j U021
A
10 (4.54)
l,2-Benzisothiazolin-3-one,l,l-dioxide, and salts
1
I 81072
j
Saccharin and salts
1
1 1*
1
4
I U202
B
100 (45.4)
Benzo[ a Janthracene
1
I 56553
1
1
Benzf a] anthracene
1,2-Benzanthracene
1
1 1*
1
1
2,4
I U018
A
10 (4.54)
Benzo[ b] (luoranthene
1
1 205992
1
1
1 1*
2
X
1 (0.454)
Benzo(k)riuoranthene
1
1 207089
1
1
1 1*
1
2
A
10 (4.54)
Benzo[a]pyrene
1
1 50328
1
3,4-Benzopyrene
1
1 1*
1
2,4
1 U022
X
1 (0.454)
3,4-Benzopyrene
i
1 50328
j
Benzo[a]pyrene
1
1 1*
1
2,4
1 U022
X
1 (0.454)
Benzo trichloride
1 98077
1
Benzene, Unchloromethyl)-
1
1 1*
1
4
I U023
A
10 (4.54)
RQLIST/CARC0485A.DTB/CON RQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:3?
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1 1
1
Statutory
1 1
1 1
1
1
1 rCrA
1 Waste
Proposed RQ
Hazardous Substance
1 CASRN | Regulatory Synonyms
1 RQ
Code
t [Number
Category
Pounds(KK)
1,2-Benzphenanthrene
1 218019 iChrysene
1 |
1
1 1*
j
2,4
1
1 U050
j
B
100 (45.4)
Benzyl chloride
1 1
I 100447 iBenzene, chloromethyl-
1 |
1100
1
1.4
I P028
A
10 (4.54)
Beryllium tt
1 l
I 7440417 iBeryllium dust tt
j j
1 1*
j
2,3,4
1 P015
1
A
10 (4.54)
Beryllium chloride
1 7787475 1
1 1
15000
1
1
1
1
1
A
10 (4.54)
Beryllium dust tt
1 1
I 7440417 IBeryllium tt
i i
1
1 1*
1
2,3,4
I P015
1
A
10 (4.54)
Beryllium fluoride
1 1
1 7787497 1
I |
1
15000
|
1
1
1
1
A
10 (4.54)
Beryllium nitrate
i i
113597994|
i i
i
(5000
1
i
i
1
A
10 (4.54)
alpha - BHC
1 1
t 319846 1
i i
1
1 1*
1
2
1
i
1
X
1 (0.454)
beta - BHC
1 1
1 319857 1
i j
1
1 1*
1
2
1
i
i
X
1 (0.454)
gamma - BHC
i i
I 58899 iHexachlorocyclohexane (gamma isomer)
1 ILindane
1
1
I 1
1
|
1,2,4
1
1 U129
1
|
X
1 (0.454)
2,2'-Bioxirane
i i
I 1464535 |l,2:3,4-Diepoxybutane
| 1
1 1*
i
4
i
1 U085
i
B
100 (45.4)
(l,P-BiphenylM,4'diamine
1 1
I 92875 [Benzidine
l i
1
1 1*
|
2,4
I U021
|
A
10 (4.54)
(l,ll-Biphenyl)-4,4,diamine,3,3,dichloro-
I I
I 91941 |3,3'~Dich]orobenzidine
1 |
1 1*
I
2,4
i
I U073
|
A
10 (4.54)
(l,r-Biphenyl)-4t4,diamine)3,3ldimethoxy-
i i
1 119904 |3,3'-Dimethoxybenzidine
| j
1 1*
I
4
i
1 U091
j
B
100 (45.4)
(l,l'Biphenyl>-4,4,-diamine,3,3,-dimethyl-
1 119937 |3,3'-Dimethylbenzidine
i i
1 1*
i
4
I U095
i
A
10 (4.54)
Bis (2-chloroethyl) ether
I . 1
I 111444 iDichloroethyl ether
1 lEthane, l,l'-oxybisI 2-chloro-
1 1
1
1 1*
1
2,4
i
1 U025
1
i
A
10 (4.54)
Bis(chloromethyl) ether
1 1
1 542881 iMethane, oxybis(chloro-
1 1
1*
|
4
1
1 P016
|
A
10 (4.54)
Bis (2-elhylhexyl) phthalate
i i
I 117817 |l,2-Benzenedicarboxylic acid, [bis(2-ethylhexyl)]
1 tester
1 |
1 1*
2,4
i
1 U028
1
1
B
100 (45.4)
1,3-Butadiene, 1,1,2,3,4,4-hexachloro-
1 1
1 87683 iHexachlorobutadiene
1 1
1*
2,4
1
1 U128
X
1 (0.454)
1-Butanamine, N-butyl-N-nitroso-
1 1
1 924163 iN-Nitrosodi-n-butylamine
l i
1*
4
1
1 U172
i
A
10 (4.54)
Butanoic acid, 4-[bis(2-chloroethyl) amino]benzene-
t 1
1 305033 (Chlorambucil
| |
4
1
1 U035
|
A
10 (4.54)
Cacodyhc acid
i i
I 75605 IHydroxydimethylarsine oxide
1 1
1*
4
i
1 U136
1
X
1 (0.454)
R QLIST/CA RC0485A.DTB/CON RQLIST.HED/CON RQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES ANp REPORTABLE QUANTITIES
- Continued
1
1
Statutor
y
1
1
1
1
I RCRA
I Waste
Proposed RQ
Hazardous Substance
1 CASRN
Regulatory Synonyms
1 RQ
Code t [Number
Category
Pounds(Kg)
Cadmium tt
1
I 7440439
¦
1 1*
|
2
A
10 (4.54)
Cadmium acetate
1
I 543908
i
1100
1
1
A
10 (4.54)
Cadmium bromide
1
I 7789426
1
1100
j
1
A
10 (4.54)
Cadmium chloride
1
110108642
i
1100
1
1
A
10 (4.54)
Calcium arsenate
1
I 7778441
i
1
11000
1
1
X
1 (0.454)
Calcium arsenite
i
152740166
i
1
11000
1
1
X
1 (0.454)
Calcium chromate
1
113765190
i
Chromic acid, calcium salt
1
|1000
1
1,4
| U032
A
10 (4.54)
Camphene, octachloro-
i
I 8001352
i
Toxaphene
1
1 1
1
1,2,4
I P123
X
1 (0.454)
Carbamie acid, ethyl ester
1
1 51796
1
Ethyl carbamate (Urethan)
1 1*
1
4
| U238
B
100 (45.4)
Carbamic acid, methylnitroso-, ethyl ester
1
1 615532
I
N-Nitroso-N-methylurethane
1 1*
1
4
I U178
X
1 (0.454)
Carbamide, N-ethyl-N-nitroso-
1
I 759739
1
N-Nitroso-N-ethylurea
1
1 1*
j
4
| U176
B
100 (45.4)
Carbamide, N-methyl-N-nitroso
1
I 684935
1
N-Nftroso-N-methylurea
1
1 1*
1
4
I U177
X
1 (0.454)
Carbamide, thio-
1
I 62566
i
Thiourea
1 1*
1
4
I U219
A
10 (4.54)
Carbamoyl chloride, dimethyl-
1
1 79447
j
Dim ethyl carbamoyl chloride
1
1 1*
j
4
I U097
X
1 (0.454)
Carbon tetrachloride
I 56235
j
Methane, tetrachloro-
15000
1
1,2,4
I U211
A
10 (4.54)
Chloral
1 75876
Acetaldehyde, trichloro-
1 1*
I
4
| U034
D
5000 (2270)
Chlorambucil
1 305033
1
1
Butanoic acid, 4-[bis(2-chloroethyl)
amino Jbenzene-
1
1 1*
1
1
4
| U035
A
10 (4.54)
Chlordane
1 57749
1
1
j
Chlordane, technical
4,7-Methanoindan, 1,2,4,5,6,7,8,8-octachloro-
3a,4,7,7a-tetrahydro-
l
1 1
1
1
1
1,2,4
| U036
X
1 (0.454)
Chlordane, technical
1 57749
1
1
|
Chlordane
4,7-Methanoindan, 1,2,4,5,6,7,8,8-octachloro-
3a,4,7,7a-tetrahydro-
1
1 1
1
1
1
1,2,4
| U036
X
1 (0.454)
Chlornaphazine
1 494031
1
2-Naphthylamine, N,N-bis(2-ehloroethyl)-
1
1 1*
1
4
| U026
A
10 (4.54)
RQL1ST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:3?
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1 1
1
Statutor
y
1 1
1 1
1
1
Ircra
I Waste
Proposed RQ
Hazardous Substance
I CASRN | Regulatory Synonyms
1 RQ
Code t |Number
Category
Pounds(Kg)
l-Chloro-2,3-epoxypropane
1 1
| 106898 lEpichlorohydrin
I lOxirane, 2-(chloromethyl>-
1 i
11000
1
1
1,4
1
| U041
B
100 (45.4)
Chloroform
1 1
1 67663 iMethane, tnchloro-
i j
15000
1
1,2,4
I U044
B
100 (45.4)
Chloromethyl methyl ether
i I
| 107302 IMethane, chloromethoxy-
i i
1 1*
I
4
I U046
A
10 (4.54)
4-Chloro-o-toluidine, hydrochloride
i i
I 3165933 iBenzenamine, 4-chloro-2-methyl-, hydrochloride
j j
1 1*
j
4
I U049
B
100 (45.4)
Chromic acid
1111157451
I |
11000
1
1
A
10 (4.54)
Chromic acid, calcium salt
1 1
(13765190 ICalcium chromate
i i
11000
1
1,4
I U032
A
10 <4.54)
Chromium Tt
1 1
I 7440473 1
I
1
I 1*
1
2
A
10 (4.54)
Chrysene
1 1
I 218019 |1,2-Benzphenanlhrene
| j
1 1*
1
2,4
| U050
B
100 (45.4)
COKE OVEN EMISSIONS
I N.A.I
i <
1 1*
1
3
X
1 (0.454)
Creosote
1 1
I 8001589|
i i
1
1 1*
1
4
I U051
A
10 (4.54)
Cupric acetoarsenite
1 1
112002038|
I i
1
1100
1
1
X
1 (0.454)
1,3-Cyelopentadiene, 1,2,3,4,5,5- hexachloro-
1 1
I 774774 iHexachlorocyclopentadiene
1 I
1
1 1
1
1,2,4
1 U130
X
1 (0.4 54)
Cyclophosphamide
i I
I 50180 |2H-l,3,2-Oxazaphosphorine,2-lbis(2-
j |chloroethyl)amino] tetrahydro-2-oxjde
1 i
1 1*
1
1
4
I U058
X
1 (0.454)
Daunomycin
l I
120830813|5,12-Naphthacenedione, (8s-cis)-8-acetyl-10-[3-
1' jamino-2,3,6-trideoxy-a]pha-L-lyxo-
1 |hexopyranoxyl)oxyl-7,8,9,10-tetrahydro-6,8,l 1-
1 |trihydroxy-l-methoxy-
1
1 1*
1
1
1
1
4
I U059
A
10 (4.54)
DDD
1 1
1 72548 iDichlorodiphenyl dichloroethane
1 ITDE
I |4,4'-DDD
1 1
1 1
1
1
1
1,2,4
I U060
X
1 (0.454)
4,4'-DDD
1 1
1 72548IDDD
1 IDichlorodiphenyl dichloroethane
1 |TDE
t 1
1
1 1
1
1
1
1,2,4
| U060
X
1 (0.454)
DDE
1 1
I 72559 |4,4'-DDE
i i
1
1 1*
1
2
X
1 (0.454)
4,4'-DDE
I i
1 72559IDDE
1 1
1
1 1*
1
2
X
1 (0.454)
RQLIST/CARC0485A.DTB/CON RQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES
- Continued
1
1
Statutor
y
1
1
1
1
1 RCRA
1 Waste
Proposed RQ
Hazardous Substance
1 CASRN
Regulatory Synonyms
1 RQ
Code t (Number
Category
Pounds(Kg)
DDT
1
1 S0293
1
1
Dichlorodiphenyl tnchloroethane
4,4'-DDT
1
I 1
1
i
1,2,4
1 U061
X
1 (0.454)
4,4'-DDT
1
I 50293
1
|
DDT
Dichlorodiphenyl tnchloroethane
I
I 1
1
1
1,2,4
1 U061
X
1 (0.454)
Decachlorooctahydro-l,3,4-metheno-2H-cyclobuta-
[ c,d)-pentalen-2-one
1
I 143500
1
|
Kepone
1
1,4
1 U142
X
1 (0.454)
Diallate
1
I 2303164
|
S-(2,3-DiclUoroaUyl) dusopropylthiocarbamate
1*
I
4
1 U062
B
100 (45.4)
Diamine
1 302012
1
Hydrazine
1 1*
4
I U133
X
1 (0.454)
2,4-Diaminotoluene
I
1 95807
1
Toluene-2,4-diamine
1
1
i
4
I U221
B
100 (45.4)
Dibenz[a,h]anthracene
I
I 53703
1
|
Dibenzo[a,h]anthraeene
1,2:5,6-Dibenzanthracene
i
1 l*
1
2,4
1 U063
X
1 (0.454)
1,2:5,6-Dibenzanthracene
1 53703
1
I
Dibenz[a,h]anthracene
Dibenzof a,h] anthracene
i
1 1*
1
i
2,4
1 U063
X
1 (0.454)
Diben2o[a,h] anthracene
i
1 53703
1
I
Dibenz[a,h]anthracene
1,2:5,6-Dibenzanthracene
i
1 l*
1
i
2,4
I U063
X
1 (0.454)
l,2:7,8-Dibenzopyrene
1
1 189559
j
Dibenz[a,i]pyrene
i
1 1*
4
1 U064
A
10 (4.54)
Dibenz[a,i]pyrene
1 189559
|
l,2:7,8-Dibenzopyrene
1
1 l*
i
4
1 U064
A
10 (4.54)
l,2-Dibromo-3-chloropropane
1 96128
1
Propane, l,2-dibromo-3-chloro-
1
1 1*
i
4
1 U066
X
1 (0.454)
S-(2,3-Dichloroallyl) dusopropylthiocarbamate
i
I 2303164
Diallate
i
1 1*
i
4
1 U062
B
100 (45.4)
Dichlorodjphenyl dichloroethane
1 7254B
1
1
|
DDD
TDE
4,4'-DDD
1
I 1
1
1
i
1,2,4
I U060
X
1 (0.454)
3,3'-Dichlorobenzidine
1
1 91941
i
(l,l'-Biphenyl>-4,4ldiamine,3l3ldichloro-
i
1 l*
i
2,4
1 U073
A
10 (4.54)
Dtchlorodiphenyl tnchloroethane
1
I 50293
1
¦
DDT
4,4'-DDT
l
I 1
1
1,2,4
1 U061
X
1 (0.454)
1,2-Dichloroethane
1 107062
1
|
Ethane, 1,2-dichloro-
Ethylene dichloride
1
15000
1
¦
1,2,4
I U077
B
100 (45.4)
1,1-DichIoroethylene
I 75354
1
1
Ethene, 1,1-dichloro-
Vinylidene chloride
1
15000
1
1
1,2,4
I U078
B
100 (45.4)
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1
I Statutor
y
1
1
1
1
Ircra
1 Waste
Proposed RQ
Hazardous Substance
1 CASRN
Regulatory Synonyms
1 RQ
Code t [Number
Category
Pounds(KR)
Dichloroethyl ether
1
I 111444
1
l
Jis (2-chloroethyl) ether
Ethane, l,l'-oxybis[ 2-chloro-
1
1 1»
1
I
2,4
1 U025
A
10 (4.54)
Dichlorophenylarsine
1
I 696286
j
Phenyl dichloroarsine
I
1
1
4
I P036
X
1 (0.454)
Dieldrin
1 60571
1
1
1
l,2,3,4,10,10-Hexachloro-6,7-epoxy-
l,4,4a,5,6,7,8,8a-octahydro-endo,exo-l,4:5,8-
di methanonaphthalene
1
| 1
1
1
I
1,2,4
1 P037
X
1 (0.454)
1,2:3,4-Diepoxy butane
1
I 1464535
|
2,2'-Bioxirane
1 1*
i
4
1 U085
B
100 (45.4)
Diethylarsine
1 692422
1
Arsine, diethyl-
1
1 1*
i
4
I P038
X
1 (0.454)
1,4-Diethylene dioxide
I
I 123911
|
1,4-Dioxane
1
1 1"
I
4
1 U108
B
100 (45.4)
N,N'-Diethylhydrazine
i
I 1615801
j
Hydrazine, 1,2-diethyl-
1
1 l4
i
4
1 U086
A
10 (4.54)
Diethylstilbestrol
I 56531
|
4,4'-Stilbenediol, alpha ^lpha'-diethyl-
1
1 1*
i
4
I U089
X
1 (0.454)
Dihydrosafrole
1 94586
1
Benzene, l,2-methylenedioxy-4-propyl-
1
1 l"
I
4
1 U090
B
100 (45.4)
3,3'-Dimethoxybenzidine
¦
1 119904
j
(l,l'-Biphenyl)-4,4'diamlne,3,3'dimethoxy-
1 I*
j
4
1 U091
B
100 (45.4)
Di me thylaminoazo benzene
1 60117
|
Benzenamine, N,N-dimethyl-4-phenylazo-
I
1 1*
i
4
1 U093
X
1 (0.454)
7,12-Dimethylbenz[ ajanthracene
1 57976
j
1,2-Benzanthracene, 7,12-dimethyl-
1
1 1*
I
4
1 U094
X
1 (0.454)
3,3'-Di methyl benzidine
1 119937
j
(l,llBiphenyl)-4,4,-dla^)ine,3,3,-dimethyl-
I
1 1*
¦
4
I U095
A
10 (4.54)
Dimethylcarbamoyl chloride
1 79447
Carbamoyl chloride, dimethyl-
1
1 1*
i
4
1 U097
X
1 (0.454)
1,1-Dimethylhydrazine
1 ' 57147
|
Hydrazine, 1,1-dimethyl-
I
1 1*
l
4
1 U098
A
10 (4.54)
1,2-Dimethyl hydrazine
1 540738
|
Hydrazine, 1,2-dimethyl-
1 1»
i
4
1 U099
X
1 (0.454)
Dimethylnitrosamine
1 62759
|
N-Nitrosodimethylamine
1
1 1*
¦
2,4
I P082
A
10 (4.54)
Dimethyl sulfate
I 77781
I
Sulfuric acid, dimethyl ester
1
1 1»
I
4
1 U103
B
100 (45.4)
Dimtrotoluene
125321146
i
11000
1
1,2
B
100 (45.4)
3,4-Dinitrotoluene
1 610399
i
1
11000
1
1,2
B
100 (45.4)
2,4-Dinitrotoluene
1
1 121142
|
Benzene, l-methyl-2,4-dinitro-
1
11000
I
1,2,4
1 U105
B
100 (45.4)
2,6-Dinitrotoluene
I 606202
1
Benzene, l-methyl-2,6-dinitro-
1
11000
1
1,2,4
1 U106
B
100 (45.4)
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQL1ST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1
1
Statutory
1
1
1
1
| RCRA
1 Waste
Proposed RQ
Hazardous Substance
1 CASRN
Regulatory Synonyms
1 RQ
Code
t [Number
Category
Pounds (Kg)
1,4-Dioxane
1
1 123911
j
1,4-Diethylene dioxide
1 1*
1
4
1
I U108
1
B
100 (45.4)
1,2-Diphenylhydrazi ne
1 122667
|
Hydrazine, 1,2-diphenyl-
I
1 1*
1
2,4
1
| U109
1
A
10 (4.54)
D i-n-pr opyl ni trosa mine
1 621647
|
N-N11 rosodi-n-pr opy 1 a m i n e
1 1*
j
2,4
1
I Ulll
j
A
10 (4.54)
Epichlorohydrin
I 106898
1
|
l-Chloro-2,3-epoxypropane
Oxirane, 2-(chloromethyl>-
11000
1
1
1,4
I U041
1
1
B
100 (45.4)
Ethanamine, N-ethyl-N-nitroso-
I 55185
|
N-Nitrosodiethylamine
I 1*
j
4
1
| U174
j
X
1 (0.454)
Ethane,
1,2-dibromo-
I 106934
I
Ethylene dibromide
1)000
1
1,4
| TJ067
i
A
10 (4.54)
Ethane,
1,2-dichloro-
1
I 107062
1
1
1,2-Dichloroethane
Ethylene dichloride
15000
1
1
1,2,4
1
| U077
1
|
B
100 (45.4)
Ethane,
1,1,1,2,2,2-hexachloro-
i
1 67721
|
H exa chloroet hane
1
1 1*
I
2,4
I U131
1
B
100 (45.4)
Ethane,
l,l'-oxybis[ 2-chloro-
i
I 111444
1
Bis (2-chloroethyl) ether
Dichloroethyl ether
1 1*
1
|
2,4
1
I U025
1
j
A
10 (4.54)
Ethane,
1,1,1,2-tetrachloro-
I 630206
I
1,1,1,2-Tetrachloroethane
1 1*
i
4
I U208
i
A
10 (4.54)
Ethane,
1,1,2,2- tetrachloro-
1
I 79345
1
1,1,2,2-Tetrachloroethane
1
1 1*
i
2,4
1
| U209
i
B
100 (45.4)
Ethane,
1,1,2-trichioro-
1
1 79005
l
1,1,2-Trichloroethane
1
1 1*
I
2,4
1
I U227
1
B
100 (45.4)
Ethanethioamide
i
1 62555
j
Thioacetamide
1 1*
i
4
1
| U218
i
A
10 (4.54)
Ethanol,
2,2*—(ni trosoi mino)bis-
1 1116547
|
N-Nltrosodiethanolamine
1
1 1»
1
4
1
| U173
i
A
10 (4.54)
Ethenamine, N-methyl-N-nitroso-
1 4549400
j
N-Nitrosomethylvinylamine
1
1 1*
|
4
l
| P084
1
A
10 (4.54)
Ethene,
chloro-
1 75014
¦
Vinyl chloride
1 1*
i
2,3,4
i
| U043
i
B
100 (45.4)
Ethene,
1,1-dichloro-
I 75354
1
|
1,1-Dichloroethylene
Vinylidene chloride
1
15000
1
1
1,2,4
1
| U078
1
i
B
100 (45.4)
Ethene,
1,1,2,2-tetrachloro-
I 127184
1
i
Tetra chloroet hylene
Tetrachloroethene
1
1 1*
1
¦
2,4
1
I U210
1
i
B
100 (45.4)
Ethyl carbamate (Urethan)
1
I 51796
I
Carbarnic acid, ethyl ester
i
i i*
4
1
l U238
|
B
100 (45.4)
Ethyl 4
4'-dichlorobenzilate
1
1 510156
1
1
Benzeneacetic acid, 4-chloro-alpha-(4-
chlorophenyl)-alpha-hydroxy-,ethyl ester
i
i i*
i
i
4
1
I U038
1
1
B
100 (45.4)
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:3?
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1
1
Statutory
1
1
1
1
1 RCRA
1 Waste
Proposed RQ
Hazardous Substance
1 CASRN
Regulatory Synonyms
1 RQ
Code
t [Number
Category
Pounds(Kg)
Ethylene dibromlde
1
I 106934
1
ithane, 1,2-dibromo-
11000
1
1,4
1
1 U067
1
A
10 (4.54)
Ethylene dichloride
| 107062
1
I
1,2-Dichloroethane
ithane, 1,2-dichloro-
15000
1
1.2,4
1
1 U077
1
B
100 (45.4)
Ethylene oxide
I 75218
1
Oxirane
1
1 1*
1
4
1
1 U115
I
A
10 (4.54)
Ethylenethiourea
1
I 96457
j
2-Imidazolidinethione
1
1 1*
1
4
1
1 U116
1
B
100 (45.4)
Ethylenimine
1 151564
j
Aziridine
1 1*
4
i
1 P054
j
X
1 (0.454)
Ethyl methanesulfonate
I 62500
i
Methanesulfonlc acid, ethyl ester
1
1 1*
1
4
1
1 U119
X
1 (0.454)
Formaldehyde
1
I 50000
|
Methylene oxide
1
11000
1
1,4
1
I U122
I
B
100 (45.4)
D-Glucopyranose, 2-deoxy-2-(3-methyl-3-
nitrosoureido)-
i
118863664
1
1
Streptozotocin
1 I*
1
1
4
1
I U206
1
1
X
1 (0.454)
Glycidylaldehyde
1
I 765344
|
1-Propanal, 2,3-epoxy-
1
1 1*
1
4
1
I U126
j
A
10 (4.54)
Guamdine, N-mtroso-N-methyl-N'-nitro-
I 70257
|
N-Methyl-N'-nltro-N-nitrosoguanidine
1
1 1*
1
4
1 U163
1
A
10 (4.54)
Heptachlor
I 76448
1
|
4,7-Methano-lH-indene,l,4,5,6,7,8,8-heptachloro-
3a,4,7,7a-tetrahydro-
1
1 1
1
1
1,2,4
1 P059
1
i
X
1 (0.454)
Heptachlor epoxide
| 1024573
I
1
1 1*
1
2
1
1
i
X
1 (0.454)
Hexachlorobenzene
i
I 118741
I
Benzene, hexachloro-
1 1*
1
2,4
l
I U127
i
A
10 (4.54)
Hexachlorobutadiene
I 87683
j
1,3-Butadiene, 1,1,2,3,4,4-hexachloro-
1
1*
1
2,4
1
I U128
i
X
1 (0.454)
Hexachlorocyclohexane (gamma isomer)
I 58899
1
i
gamma - BHC
Lindane
1
1
1,2,4
1
1 U129
1
i
X
1 (0.454)
Hexachlorocyclopentadi ene
1
1 774774
|
1,3-Cyclopentadiene, 1,2,3,4,5,5- hexachloro-
1
1,2,4
1
1 U130
j
X
1 (0.454)
1,2,3,4,10,10-Hexachloro-6,7-epoxy-
1,4,4a, 5,6,7,8,8a-octahydro-endo ,exo-l, 4:5,8-
dimethanonaphthalene
1
I 60571
1
1
I
Dieldrin
1
1
1,2,4
1
1 P037
1
1
X
1 (0.454)
Hexachloroethane
1
I 67721
I
Ethane, 1,1,1,2,2,2-hexachloro-
1
1 1»
1
2,4
1
1 U131
I
B
100 (45.4)
1,2,3,4,10-10-Hexachloro-1,4,4a, 5,8,8a-hexa hydro-
l,4:5,8-endo,exo-dimethanonaphthalene
i
I 309002
1
j
Aldrin
1
1 1
I
1
1,2,4
I
I P004
1
X
1 (0.454)
Hydrazine
I 302012
1
Diamine
1
1 1*
1
4
1 U133
1
X
1 (0.454)
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1
1
Sta
tory
1
1
1
1
1 RCRA
I Waste
Proposed RQ
Hazardous Substance
I CASRN
Regulatory Synonyms
1 RQ
Code t [Number
Category
Pounds(Kg)
Hydrazine, 1,2-diethyl-
1
I 1615801
j
N,N'-Diethylhydrazine
1
1 1*
|
1
I U086
j
A
10 (4.54)
Hydrazine, 1,1-dimethyl-
1 57147
|
1,1-Dimethylhydrazine
1 1»
|
| U098
j
A
10 (4.54)
Hydrazine, 1,2-dimethyl-
1 540738
|
1,2-Dimethylhydrazine
1 1*
1
I U099
|
X
1 (0.454)
Hydrazine, 1,2-diphenyl-
1
| 122667
|
1,2-Diphenylhydrazine
1 1*
1
I U109
j
A
10 (4.54)
Hydroxydimethylarsine oxide
I 75605
|
Cacodylic acid
1 1*
1
| U136
j
X
1 (0.454)
2-1 m i da zol idi n et hi one
| 96457
j
Ethylenethiourea
1 1*
I
1 U116
I
B
100 (45.4)
lndeno[ l,2,3-cd]pyrene
I 193395
l,10-(l,2-Phenylene)pyrene
1 1*
1
1
| U137
j
A
10 (4.54)
Isocyanic acid, methyl ester
I 624839
j
Methyl isocyanate
1 1*
1
I P064
X
1 (0.454)
Isosafrole
1 120581
j
Benzene, l,2-methy]enedioxy-4-propenyl-
i i*
i
I U141
j
B
100 (45.4)
Kepone
1 143500
1
1
Decachlorooctahydro-l,3,4-metheno-2H-cyclobuta-
Ic,d]-pentalen-2-one
i
i i
i
i
| U142
1
|
X
1 (0.454)
Lasiocarpine
1
I 303344
1
i i*
j
I U143
i
A
10 (4.54)
Lead acetate
I 301042
1
Acetic acid, lead salt
15000
1
1
| U144
i
B
100 (45.4)
Lead arsenate
1
1 7784409
1
1
15000
i
1
1
1
X
1 (0.454)
Lead phosphate
1
I 7446277
¦
Phosphoric acid, lead salt
1
1 1*
j
1
| U145
i
A
10 (4.54)
Lead subacetate
| 1335326
1
1
1 1*
i
1
I U146
¦
B
100 (45.4)
Lindane
1
| • 58899
1
i
gamma - BHC
Hexachlorocyclohexane (gamma isomer)
1
1 1
1
i
1
1
4 I U129
1
i
X
1 (0.454)
Lithium chromate
114307358
1
1
11000
1
1
1
1
A
10 (4.54)
Melphalan
1
I 148823
j
Alanine, 3-[p-bis(2-chloroethyl(amino]phenyl-,L-
1
1 1*
1
1
| U150
I
X
1 (0.454)
Methane, chloromethoxy-
I 107302
|
Chloromethyl methyl ether
1
1 1»
1
1
| U046
I
A
10 (4.54)
Methane, lodo-
I 74884
1
Methyl iodide
1
1 1*
1
1
I U138
i
A
10 (4.54)
Methane, oxybis(chloro-
i
I 542881
|
Bis(chloromethyl) ether
1
1 1*
1
1
I P016
i
A
10 (4.54)
Methane, tetrachloro-
| 56235
1
Carbon tetrachloride
1
15000
1
1
1
2,4 | U211
1
A
10 (4.54)
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:3?
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1 1
1
Statutory
1 1
1 1
1
1
1RCRA
1 Waste
Proposed RQ
Hazardous Substance
I CASRN I Regulatory Synonyms
1 RQ
Code
t [Number
Category
Pounds(Kg)
Methane, trichloro-
| 67663 IChloroform
1 1
15000
1
1.2,4
1
1 U044
1
B
100 (45.4)
Methanesulfomc acid, ethyl ester
1 1
| 62500 |Ethyl methanesulfonate
1 |
1
1 1*
1
4
1
1 U119
j
X
1 (0.454)
4,7-Methano-lH-indene,l,4,5,6,7,8,8-heptachloro-
3a,4,7,7a-tetrahydro-
i i
| 76448 (Heptachlor
1 1
j j
1
| 1
1
1
1,2,4
I P059
1
I
X
1 (0.454)
4,7-Methanoindan, 1,2,4,5,6,7,8,8-octachloro-
3a,4,7,7a-tetrahydro-
I 57749 IChlordane
I IChlordane, technical
j |
1
1 1
1
|
1,2,4
i
1 U036
1
j
X
1 (0.454)
2-Methylaziridine
1 1
I 75558 |l,2-Propylenimine
1 i
1 1*
1
4
I P067
j
A
10 (4.54)
4,4'-Methylenebis(2-chloroanilme)
I I
I 101144 IBenzenamine, 4,4f-methy]enebis(2-chloro-
l i
1 1*
i
4
1 U158
j
B
100 (45.4)
3-Methylcholanthrene
l I
I 56495 |Benz[j]aceanthrylene, l,2-dihydro-3-methyl-
1 1
I 50000 IFormaldehyde
j |
1 1*
|
4
1 U157
1
A
10 (4.54)
Methylene oxide
1
11000
1
1,4
1
1 U122
j
B
100 (45.4)
Methyl iodide
1 1
I 74884 iMethane, lodo-
t I
1 1*
1
4
1 U138
1
A
10 (4.54)
Methyl isocyanate
1 1
| 624839 llsocyanie acid, methyl ester
1
1
1 1»
1
4
1
1 P064
j
X
1 (0.454)
N - M et hyl-N '-ni tro-N -ni t rosoguamdi ne
i i
I 70257 (Guanidine, N-nitroso-N-methyl-N'-nitro-
1 |
1 1*
1
4
I U163
j
A
10 (4.54)
Methyl thiouracil
l I
I 56042 |4(lH}-Pyrimidinone, 2,3-dihydro-6-methyl-2-thioxo-
i i
1 1*
1
4
1 U164
A
10 (4.54)
Mitomycin C
i I
I 50077 |Azirino(2',3l:3,4)pyrrolo(l,2-a)indole-4,7-dione,6-
I |amino-8- [((aminocarbonyl)oxy)methyl]-
I |l,la,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-
1 |
1 1»
1
1
1
4
1 U010
1
1
j
A
10 (4.54)
5,12-Naphthacenedione, (8s-cis)-8-acetyl-10-[3-
amino-2,3,6-trideoxy-alpha-L-lyxo-
hexopyranoxyl k>xyl-7,8,9,10-tetrahydro-6,8,11-
tnhydroxy-l-methoxy-
1 1
120830813 iDaunomycin
1 ' 1
1 1
1 1
1 |
1 1*
1
1
1
1
4
1 U059
1
1
1
1
A
10 (4.54)
2,7-Naphthalenedisulfonic acid,3,3'-[(3,3'-
di met hyl-Q.l'-bi phenyl >-4,4'-diyl)-bis(a zo)]bis(5-
amino-4-hydroxy)-tetrasodium salt
1 1
| 72571 ITrypan blue
1 1
1 1
i i
1 1»
1
1
1
4
1
1 U236
1
1
¦
B
100 (45.4)
1-Naphthylamine
i 1
I 134327 lalpha-Naphthylamine
1 1
1
1 1*
1
4
1 U167
1
A
10 (4.54)
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
Hazardous Substance
1
1
1
1 CASRN
Regulatory Synonyms
1
1
1
1 RQ
Statutory
1RCRA
I Waste
Code t [Number
Proposed RQ
Category | Pounds(Kg)
2-Naphthylamfne
1
I 91S98
j
beta-Naphthylamine
I
1
4
1
I U168
j
B
100 (45.4)
alpha-Naphthylamme
1 134327
j
1-Naphthylamine
1 1*
i
4
| U167
j
A
10 (4.54)
beta-Naphthylamine
1 91598
1
2-Naphthylamine
1 1»
1
4
I U168
j
B
100 (45.4)
2-Naphthylamlne, N,N-bis(2-chloroethyl)-
1
1 494031
|
Chlornaphazine
1 1*
1
4
| U026
|
A
10 (4.54)
Nickel tt
I 7440020
i
1 1*
I
1
1
1
A
10 (4.54)
Nickel ammonium sulfate
1
115699180
1
I
15000
|
1
1
1
j
A
10 (4.54)
Nickel carbonyl
1
113463393
¦
Nickel tetracarbonyl
1 1*
j
4
| P073
1
A
10 (4.54)
Nickel chloride
1 7718549
i
15000
j
1
I
i
i
A
10 (4.54)
Nickel cyanide
1
1 557197
l
Nickel(n) cyanide
1110}
j
4
i
1 P074
|
A
10 (4.54)
Nickel(II) cyanide
i
1 557197
j
Nickel cyanide
inoj
4
I P074
1
A
10 (4.54)
Nickel hydroxide
112054487
¦
11000
1
1
i
1
1
A
10 (4.54)
Nickel nitrate
1
114216752
I
1
15000
1
1
1
1
1
A
10 (4.54)
Nickel sulfate
1
1 7786814
¦
1
15000
j
1
t
1
1
A
10 (4.54)
Nickel tetracarbonyl
1
113463393
i
Nickel carbonyl
1
1 1*
1
4
I P073
j
A
10 (4.54)
2-Nitropropane
1
I 79469
1
Propane, 2-nitro-
1 1*
|
4
I U171
j
B
100 (45.4)
N -N i t rosodi-n-bu t yla m i ne
i
1 924163
i
1-Butanamine, N-butyl-N-nitroso-
I 1*
j
4
I U172
1
A
10 (4.54)
N-Nitrosodiethanolamine
1
I 1116547
I
Ethanol, 2,2'-(nitrosoimino)bis-
1
1 1*
i
4
1
| U173
1
A
10 (4.54)
N-Nitrosodiethylamine
1
1 55185
|
Ethanamine, N-ethyl-N-nitroso-
1 1*
1
4
i
I U174
|
X
1 (0.454)
N-Nitrosodimethylamine
i
1 62759
j
Dimethylni trosamine
1 1»
I
2,4
I P082
j
A
10 (4.54)
N-Nitrosodi-n-propylamine
I 621647
i
Di-n-propylnitrosamine
1 1*
i
2,4
I Ulll
A
10 (4.54)
N-Nitroso-N-ethylurea
1
1 759739
|
Carbamide, N-ethyl-N-nitroso-
1 1*
|
4
I U176
|
B
100 (45.4)
N-Nitroso-N-methylurea
i
1 684935
1
Carbamide, N-methyl-N-nitroso
1 1*
i
4
I U177
¦
X
1 (0.454)
N-Nitroso-N-methylurethane
1 615532
1
Carbamic acid, methylmtroso-, ethyl ester
1
1 1*
1
4
1
I U178
1
X
1 (0.454)
RQLIST/CARC0485A.DTB/CONRQL1ST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1 1
1
Statutor
y
1 1
1 1
1
1
1 RCRA
1 Waste
Proposed RQ
Hazardous Substance
I CASRN | Regulatory Synonyms
1 RQ
Code t (Number
Category
Pounds(Kg)
N-Nltrosomethylvinylamine
1 1
I 4549400 lEthenamine, N-methyl-N-nitroso-
1 I
1
1 1*
1
4
I P084
A
10 (4.54)
N-Nitrosopiperidine
1 1
| 100754 (Pyridine, hexahydro-N-nitroso-
1 i
1 1*
I
4
I U179
X
1 (0.454)
N-Nitrosopyrrolidine
l I
| 930552 IPyrrole, tetrahydro-N-nitroso-
1 |
i 1*
|
4
i U180
X
1 (0.454)
5-Nltro-o-toluidine
i i
I 99S58 iBenzenamine, 2-methyl-5-nitro-
1 1
1 1*
i
4
1 U181
B
100 (45.4)
1,2-Oxathiolane, 2,2-dioxide
1 1
| 1120714 |l,3-Propane sultone
i i
1
1 1*
i
4
I U193
A
10 (4.54)
2H-l,3,2-Oxazaphosphorine,2-[bis(2-
chloroethylfemino] tetrahydro-2-oxide
1 1
I 50180 (Cyclophosphamide
1 1
l i
1
1 1*
1
1
4
I U05B
X
1 (0.454)
Oxirane
I l
I 75218 (Ethylene oxide
i i
1
1 1*
4
I U115
A
10 (4.54)
Oxirane, 2-(ch)oromethyl)-
I i
I 106898 lEpichlorohydrin
| | l-Chloro-2,3-epoxypropane
i |
11000
1
1
1,4
I U041
B
100 (45.4)
Parathion
i i
| 56382 |Phosphorothioc acid, O.O-diethyl
1 I 0-(p-nitrophenyl) ester
1 |
1
1 1
1
1
1.4
I P089
A
10 (4.54)
Pentaehloroni trobenzene
1 1
I 82688 iBenzene, pentaehloroni tro-
1 I
1 1*
1
4
1 U185
B
100 (45.4)
Pentachlorophenol
1 1
| 87865 (Phenol, pentachloro-
i i
1 10
1
1,2,4
1 U242
A
10 (4.54)
Phenacetin
I l
| 62442 (Acetamide, N-(4-ethoxyphenyl)-
1 |
1 1*
1
4
1 U187
B
100 (45.4)
Phenol, pentachloro-
i i
| 87865 iPentachlorophenol
1
1 10
1
1,2,4
I U242
A
10 (4.54)
Phenol, 2,4,5-trichloro-
1 1
1 95954 12,4,5-TrichIorophenol
1 1
1 10
1
1,4
I U230
A
10 (4.54)
Phenol, 2,4,6-trichloro-
1 I
| 88062 12,4,6-Trichlorophenol
1 |
1 10
1
1,2,4
1 U231
A
10 (4.54)
Phenyl dichloroarsine
l l
I 696286 (Dichlorophenylarsine
t i
1 1*
1
4
I P036
X
1 (0.454)
l,10-(l,2-Phenylene)pyrene
i 1
I 193395 |lndeno[ l,2,3-cd}pyrene
l i
1
1 1*
1
2,4
I U137
A
10 (4.54)
Phosphoric acid, lead salt
1 i
| 7446277 |Lead phosphate
i i
1
1 1»
1
4
I U145
A
10 (4.54)
Phosphorothioc acid, 0,0-diethyl O-(p-mtrophenyl)
ester
i i
| 56382 IParathion
1 1
1 1
1
1 1
1
1
1,4
| P089
A
10 (4.54)
Polychlonnated biphenyls (PCBs)
1 1
| 1336363 1
¦ j
1 10
1
1,2
X
1 (0.454)
Potassium arsenate
I 77844101
1 1
liooo
1
1
X
1 (0.454)
RQLIST/CARC0485A.DTB/CONFQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES
- Continued
Hazardous Substance
1
1
1
I CASRN
Regulatory Synonyms
1
1
1
1 RQ
Statutory
1 RCRA
I Waste
Code t Number
Proposed RQ
Category | Pounds(Kg)
Potassium arsenite
1
110124502
j
1
11000
i
1
1
1
|
X
1 (0.454)
Potassium bichromate
1
| 7778509
1
1
liooo
1
1
1
1
1
A
10 (4.54)
Potassium chromate
I 7789006
1
1
11000
1
1
1
1
1
A
10 (4.54)
1-Propanal, 2,3-epoxy-
1
I 765344
|
Glycidylaldehyde
1
1 1*
1
4
1
1 ui 26
j
A
10 (4.54)
Propane, l,2-dibromo-3-chloro-
1 96128
1
l,2-Dibromo-3-chloropropane
1
1 1*
1
4
1 U066
i
X
1 (0.454)
Propane, 2-nitro-
1
I 79469
I
2-Nitropropane
1
1 1*
1
4
1
1 Ul 71
|
B
100 (45.4)
1,3-Propane sultone
i
I 1120714
1
1,2-Oxathiolane, 2,2-dioxide
1 1*
1
4
i
I U193
»
A
10 (4.54)
1-Propanol, 2,3-dibromo-, phosphate (3:1)
1
I 126727
1
Tris(2,3-dibromopropyl) phosphate
1
1 1*
1
4
1
1 U235
I
B
100 (45.4)
2-Propenenitnle
i
I 107131
j
Acrylonitrile
1
1100
1
1,2,4
1
I U009
|
B
100 (45.4)
1,2-Propylenimine
I 75558
|
2-Methylaziridine
1
1 1»
1
4
I P067
1
A
10 (4.54)
Pyridine, hexahydro-N-nltroso-
I 100754
|
N-Nitrosopiperidine
1
1 1»
1
4
1
I Ul 79
I
X
1 (0.454)
4(lH)-Pyrim]dinonet 2,3-dihydro-6-methyl-2-thioxo-
1 56042
|
Methyl thiouracil
1
1 1*
1
4
1
1 Ul 64
1
A
10 (4.54)
Pyrrole, tetrahydro-N-nitroso-
i
I 930552
j
N-Nitrosopyrrolidine
1
1 1*
j
4
i
I U180
1
X
1 (0.454)
RADIONUCLIDES
1 N.A.
1
1
1 1»
1
1
1
i
X
IS (0.454)
Saccharin and salts
1
I 81072
j
l,2-Benzisothiazolin-3-one,l,l-d]oxfde, and salts
1
1 1*
1
4
1
I U202
1
B
100 (45.4)
Safrole
1 .94597
j
Benzene, l,2-methylenedioxy-4-allyl-
1
1 1*
1
4
I
I U203
B
100 (45.4)
Selenium disulfide
I 7488564
I
Sulfur selenide
1
1 1»
1
4
I U205
i
B
100 (45.4)
L-Serine, diazoacetate (ester)
1
1 115026
1
Azaserine
1
1 1*
j
4
1
I U015
I
A
10 (4.54)
Sodium arsenate
i
1 7631892
I
1
11000
1
1
1
1
i
X
1 (0.454)
Sodium arsenite
1
I 7784465
i
1
11000
1
1
1
i
i
X
1 (0.454)
Sodium bichromate
1
110588019
i
1
11000
1
1
1
1
i
A
10 (4.54)
Sodium chromate
I
I 7775113
i
1
|1000
1
1
1
i
i
A
10 (4.54)
4,4'-Stilbenediol, alpha,alpha'-diethyl-
1
I 56531
1
Diethylstilbestrol
1
1 1*
1
4
i
I U089
1
X
1 (0.454)
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1
1
Statutor
y
1
1
1
1
I RCRA
I Waste
Proposed RQ
Hazardous Substance
1 CASRN
Regulatory Synonyms
1 RQ
Code t [Number
Category
Pounds (Kg)
Streptozotocin
1
118883664
1
I
D-Glucopyranose, 2-deoxy-2-(3-methyl-3-
nitrosoureido)-
1 1*
1
l
4
I U206
X
1 (0.454)
Strontium chromate
1
| 7789062
j
1
11000
1
1
A
10 (4.54)
Sulfur selenide
| 7488564
I
Selenium disulfide
1
1 1*
1
4
I U205
B
100 (45.4)
Sulfuric acid, dimethyl ester
i
I 77781
j
Dimethyl sulfate
1
1 1*
1
4
I U103
B
100 (45.4)
TDE
| 72S48
1
1
1
DDD
Dichlorodiphenyl dichloroethane
4,4'-DDD
1
1 1
1
1
1
1,2,4
I U060
X
1 (0.454)
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)
1
I 1746016
j
1
1 I*
1
2
X
1 (0.454)
1,1,1,2-Tetrachloroethane
I 630206
j
Ethane, 1,1,1,2-tetrachloro-
1
1 1*
1
4
1 U208
A
10 (4.54)
1,1,2,2-Tetrachloroethane
I 79345
i
Ethane, 1,1,2,2-tetrachloro-
1
1 1*
1
2,4
1 U209
B
100 (45.4)
Tetrachloroethene
1
I 127184
1
1
Tetrachloroethylene
Ethene, 1,1,2,2-tetrachloro-
1
1 1*
1
1
2,4
I U210
B
100 (45.4)
Tetrachloroethylene
1
I 127184
1
i
Ethene, 1,1,2,2-tetrachloro-
Tetrachloroethene
1
1 1*
1
1
2,4
I U210
B
100 (45.4)
Thioacetamide
1
1 62555
j
Ethanethioamide
1
1 1*
1
4
1 U218
A
10 (4.54)
Thiourea
| 62566
j
Carbamide, thio-
1
1 1*
1
4
1 U219
A
10 (4.54)
Toluene-2,4-diamine
| 95807
I
2,4-Diaminotoluene
1
1 1»
1
4
I U221
B
100 (45.4)
o-Toluidine hydrochloride
| 636215
j
Benzenamine, 2-methyl-, hydrochloride
1
1 1*
1
4
1 U222
B
100 (45.4)
Toxaphene
I 8001352
j
Camphene, octachloro-
1
1 1
1
1,2,4
1 P123
X
1 (0.454)
lH-l,2,4-Triazol-3-amine
I 61825
i
Amitrole
1
1 1*
1
4
I U011
B
100 (45.4)
1,1,2-Tnchloroethane
1
| 79005
j
Ethane, 1,1,2-tnchloro-
1
1 1*
1
2,4
I U227
B
100 (45.4)
Trichloroethene
| 79016
|
Trichloroethylene
1
11000
1
1,2,4
1 U228
B
100 (45.4)
Trichloroethylene
I 79016
i
Trichloroethene
1
11000
1
1,2,4
I U228
B
100 (45.4)
Trichlorophenol
i
125167822
1
1 10
1
1
A
10 (4.54)
2,3,4-Trichlorophenol
i
115950660
1
1 10
1
A
10 (4.54)
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
Hazardous Substance
1
1
1
1 CASRN
Regulatory Synonyms
1
1
1
1 RQ
Statutory
Ircra
j Waste
Code t [Number
Proposed RQ
Category | Pounds(Kg)
2,3,5-Trichlorophenol
1
I 933788
j
1 10
I
A
10 (4.54)
2,3,6-Trichlorophenol
1 933755
1
I 10
1
A
10 (4.54)
2,4,5-Trichlorophenol
1
I 95954
j
2,4,5-Trichlorophenol
1 10
1
1,4
| U230
A
10 (4.54)
2,4,6-Trichlorophenol
1 88062
j
Phenol, 2,4,6-Trichloro
1 10
1
1,2,4
| U231
A
10 (4.54)
3,4,5-Trichlorophenol
1 609198
1
1 10
1
A
10 (4.54)
2,4,5-Trichlorophenol
1
1 95954
j
Phenol, 2,4,5-trichloro-
1 10
1,4
| U230
A
10 (4.54)
2,4,6-Trichlorophenol
1 88062
1
Phenol, 2,4,6-trichloro
1 10
1,2,4
| U231
A
10 (4.54)
Tris(2,3-dibromopropyl) phosphate
i
1 126727
j
1-Propanol, 2,3-dibromo-, phosphate (3:1)
1
1 1*
1
4
| U235
B
100 (45.4)
Trypan blue
1 72571
2,7-NaphthalenedisuIfonic acid,3,3'-[(3,3'-
1
1 1*
4
| U236
B
100 (45.4)
1
dimethyl-0,l,-biphenyl)-4,4,-diyl)-bis(azo))bis(5-
1
1
1
amino-4-hydroxyHetrasodium salt
1
1
Unlisted Hazardous Wastes
1
1
1
1
Characteristic of EP Toxicity
1
1
Arsenic
1
1 I*
4
I D004
X
1 (0.454)
Cadmium
1
1 1*
4
| D006
A
10 (4.54)
Chromium(VI)
1
1 1*
4
| D007
A
10 (4.54)
Lead
1
1 1*
2,4
I D008
B
100 (45.4)
Lindane
1
1 1*
1,4
| D013
X
1 (0.454)
Toxaphene
1
1
1 1*
1,4
| D015
X
1 (0.454)
Uracil, 5-[bis(2-chloroethyl)amino]-
1
1 66751
|
Uracil mustard
1
1 1*
4
I U237
A
10 (4.54)
Uracil mustard
I ' 66751
j
Uracil, 5-[bis(2-chloroethyl)amino]-
1
1 1*
1
4
I U237
A
10 (4.54)
Vinyl chloride
1 75014
1
Ethene, chloro-
1
1 1*
1
2,3,4
| U043
B
100 (45.4)
Vinylidene chloride
1
I 75354
1,1-Dichloroethylene
1
15000
1,2,4
| U078
B
100 (45.4)
1
1
Ethene, 1,1-dichloro-
1
1
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
Hazardous Substance
1 1
1 1
1 1
1 CASRN 1
Regulatory Synonyms
1
1
1
1 RQ
Statutory
1RCRA
1 Waste
Code t [Number
Proposed RQ
Category I Pounds(Kg)
F001
1 1
1 1
1 1*
4
1
1 F001
A
10 (4.54)
The following spent halogenated solvents used in
1 1
1
1
degreasing and sludges from the recovery of these
1 1
1
1
solvents in degreasing operations:
1 1
1
1
(a) Tetrachloroethylene
I 127184 1
1 1*
4
1
B
100 (45.4)
(b) Trichloroethylene
I 790161
11000
1
B
100 (45.4)
(c) Methylene chloride
I 750921
1 1*
4
1
C
1000 (454)
(d) 1,1,1-Trichloroethane
| 715561
1 1*
4
1
C
1000 (454)
(e) Carbon tetrachloride
I 56235 1
15000
1
A
10 (4.54)
(f) Chlorinated fluorocarbons
1 N.A.I
1 |
1 1*
1
4
1
¦
D
5000 (2270)
F002
1 1
1 1
1
1 1*
4
I F002
B
100 (45.4)
The following spent halogenated solvents and the
1 1
1
1
still bottoms from the recovery of these solvents:
1 1
1
1
(a) Tetrachloroethylene
I 127184 1
1 1*
4
1
B
100 (45.4)
(b) Methylene Chloride
I 750921
1 1*
4
1
C
1000 (454)
(c) Trichloroethylene
| 790161
11000
1
B
100 (45.4)
(d) 1,1,1-Trichloroethane
| 715561
1 1»
4
1
C
1000 (454)
(e) Chlorobenzene
| 108907 1
1100
1
B
100 (45.4)
(f) l,l,2-Trichloro-l,2,2-
| 761311
1 1»
4
1
D
5000 (2270)
trifluoroethane
1 1
1
1
(g) o-Dichlorobenzene
| 95501 |
1100
1
B
100 (45.4)
(h) Trichlorofluoromethane
I 75694 1
i |
1 1*
1
4
1
1
D
5000 (2270)
F0O6
1 1
1 1
1 1*
4
1
1 F006
A
10 (4.54)
Wastewater treatment sludges from electroplating
1 1
1
1
operations except from the following processes:
1 1
1
1
(1) sulfuric acid anodizing of aluminum; (2) tin
1 1
1
1
plating on carbon steel; (3) zinc plating
1 1
1
1
(segregated basis) on carbon steel; (4) aluminum
1 1
1
1
or zinc-aluminum plating on carbon steel; (5)
1
1
cleaning/stripping associated with tin, zinc and
1 1
1
1
aluminum plating on carbon steel; and
1 1
1
1
(6) chemical etching and milling of aluminum
1 1
1 1
1
1
1
F019
1 1
1 1
1
1 1»
4
1 F019
A
10 (4.54)
Wastewater treatment sludges from the chemical
1 1
1
1
conversion coating of aluminum
1 1
1 1
1
1
1
1
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1 1
1
Statutory
1 1
1 1
1
1
1 RCRA
I Waste
Proposed RQ
Hazardous Substance
I CASRN |
Regulatory Synonyms
1 RQ
Code t (Number
Category 1 Pounds(Kg)
F020
Wastes (except wastewater and spent carbon from
hydrogen chloride purification) from the
production or manufacturing use (as a reactant,
chemical intermediate, or component in a
formulating process) of tn- or tetrachlorophenol,
or of intermediates used to produce their
pesticide derivatives. (This listing does not
include wastes from the production of
Hexachlorophene from highly purified 2,4,5-
trichlorophenol.).
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 !•
1
1
1
1
1
1
1
1
1
1
I
1
4 | F020
1
1
1
1
1
1
1
1
1
1
1
X I 1 (0.454)
1
1
1
1
1
1
1
1
1
1
1
F021
Wastes (except wastewater and spent carbon from
hydrogen chloride purification) from the
production or manufacturing use (as a reactant,
chemical intermediate, or component in a
formulating process) of pentachlorophenol, or of
intermediates used to produce its derivatives.
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
I 1
1 1*
1
1
1
1
1
1
i
1
4 I F021
1
1
1
1
1
1
1
1
X I 1 (0.454)
1
1
1
1
1
1
1
F022
Wastes (except wastewater and spent carbon from
hydrogen chloride purification) from the
manufacturing use (as a reactant, chemical
intermediate, or component in a formulating
process) of tetra-,
pent a-, or hexachlorobenzenes under alkaline
conditions.
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1
1 1*
1
1
1
1
1
1
1
1
4 I F022
1
1
1
1
1
1
1
1
X 1 1 (0.454)
1
1
1
1
1
1
1
F023
Wastes (except wastewater and spent carbon from
hydrogen chloride purification) from the
production of materials on equipment previously
used for the production or manufacturing use (as a
reactant, chemical intermediate,
or component in a formulating process) of tri— and
tetrachlorophenols. (This listing does not
include wastes from equipment used only for the
production or use of Hexachlorophene fromhighly
purified 2,4,5-trichlorophenol.).
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
i !
1 1
1 1
1
1 1*
1
1
1
1
1
1
1
1
1
1
1
1
4 | F023
1
1
1
1
1
1
1
1
1
1
1
1
X I 1 (0.454)
1
1
1
1
1
1
1
1
1
1
1
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1 1
1
Statutory
1 1
1 1
1
1
1 lltCRA
1 I Waste
Proposed RQ
Hazardous Substance
1 CASRN 1
Regulatory Synonyms
1 RQ
1 Code t (Number
Category | Pounds(Kg)
F024
Wastes, including but not limited to, distillation
residues, heavy ends, tars, and reactor cleanout
wastes, from the production of chlorinated
aliphatic hydrocarbons, having carbon content from
one to five, utilizing free radical catalyzed
processes. (This listing does not include light
ends, spent filters and filter aids, spent
dessicants(sic), wastewater, wastewater treatment
sludges, spent catalysts, and wastes listed in
Section 261.32.).
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 I
| |
1
1 1*
1
1
1
1
1
1
1
1
1
1
1
1 1
1 4 I F024
1 1
1 1
1 i
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 i
X I 1 (0.454)
1
1
1
1
1
1
1
1
1
1
1
F026
Wastes (except wastewater and spent carbon from
hydrogen chloride purification) from the
production of materials on equipment previously
used for the manufacturing use
(as a reactant, chemical intermediate, or
component in a formulating process) of tetra-,
penta-, or hexachlorobenzene under alkaline
conditions.
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1*
1
1
1
1
1
1
1
1
I
1 1
I 4 | F026
i i
i i
i i
i i
i i
i i
i i
i i
i i
1
X I 1 (0.454)
1
1
1
1
1
1
1
1
F027
Discarded unused formulations containing trl—,
tetra-, or pentachlorophenol or discarded unused
formulations containing compounds derived from
these chlorophenols. (This listing does not
include formulations containing Hexachlorophene
synthesized from prepurified 2,4,5-trichlorophenol
as the sole component.).
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1
1 !•
i
i
i
i
i
i
i
i
1 1
1 4 | F027
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1
X I 1 (0.454)
1
1
1
1
1
1
1
F028
Residues resulting from the incineration or
thermal treatment of soil contaminated with EPA
Hazardous Waste Nos. F020, F021, F022, F023, F026,
and F027.
1 1
1 1
1 1
1 1
1 1
1 1
1 1
I
1 1*
i
i
i
i
i
1 1
I 4 | F028
i i
i i
i i
i i
• *
1
X | 1 (0.454)
1
1
1
1
K001
Bottom sediment sludge from the .treatment of
wastewaters from wood preserving processes that
use creosote and/or pentachlorophenol
1 1
1 1
1 1
1 1
1 1
| |
i
1
i
i
i
¦
1 1
1 4 ( K001
1 1
1 1
I 1
1 |
1
A | 10 (4.54)
1
1
1
1
K 002
Wastewater treatment sludge from the production of
chrome yellow and orange pigments
1 1
1 1
1 1
1 1
1 1
11»
i
i
i
1 1
1 4 | K002
1 1
1 1
1 1
1
A | 10 (4.54)
1
1
1
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES
- Continued
1 1
1
Statutory
1 1
1 1
1
1
1 RCRA
I Waste
Proposed RQ
Hazardous Substance
1 CASRN I
Regulatory Synonyms
1 RQ
Code t [Number
Category
Pounds (Hp)
K003
Wastewater treatment sludge from the production of
molybdate orange pigments
1 1
1 1
1 1
1 1
1 I
1
1 1*
1
1
I
1
4 | K003
1
1
|
A
10 (4.54)
K 004
Wastewater treatment sludge from the production of
zinc yellow pigments
1 1
1 1
1 1
1 1
1 I
1
1
1
I
4 | K004
1
1
|
A
10 (4.54)
K005
Wastewater treatment sludge from the production of
chrome green pigments
1 1
1 1
1 1
1 1
1 1
l
1 1*
1
1
i
4 t K005
1
1
j
A
10 (4.54)
K006
Wastewater treatment sludge from the production of
chrome oxide green pigments (anhydrous and
hydrated)
1 1
1 1
1 1
1 1
1 1
1 1
1 1*
1
1
1
1
4 | K006
1
1
1
j
A
10 (4.54)
K 007
Wastewater treatment sludge from the production of
iron blue pigments
I I
1 1
1 1
1 1
1 1
1 1*
1
1
1
4 | K007
1
1
|
A
10 (4.54)
K008
Oven residue from the production of chrome oxide
green pigments
1 1
1 1
1 1
1 1
1 |
1 1*
1
1
i
4 | K008
1
1
|
A
10 (4.54)
K 009
Distillation bottoms from the production of
acetaldehyde from ethylene
1 1
1 1
1 1
1 1
1 1
1
1 1*
1
1
1
4 | K009
1
1
|
B
100 (45.4)
K010
Distillation side cuts from the production of
acetaldehyde from ethylene
1 1
1 1
t 1
1 1
1 |
1
1 1*
\
1
i
4 | K010
1
1
|
B
100 (45.4)
K0U
Bottom stream from the wastewater stripper in the
production of acrylonitrile
1 1
1 1
1 1
1 1
1 1
1 1*
1
1
1
1
4 | K011
1
1
|
A
10 (4.54)
K013
Bottom stream from the acetonitrile column in the
production of acrylonitrile
1 1
1 1
1 1
1 1
1 1
1 1*
1
1
1
4 | K013
1
1
1
A
10 (4.54)
K 01 5
Still bottoms from the distillation of benzyl
chloride
1 1
1 1
1 1
1 1
1 1
1
1 1*
1
1
1
4 | K015
1
1
1
A
10 (4.54)
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:3?
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1 1
1
Statutory
1 1
1 1
1
1
I RCRA
1 Waste
Proposed RQ
Hazardous Substance
1 CASRN I
Regulatory Synonyms
1 RQ
Code
t [Number
Category
Pounds(Kg)
K016
Heavy ends or distillation residues from the
production of carbon tetrachloride
1 1
1 1
1 1
1 1
I 1
1 1»
1
1
I
4
1
I K016
1
1
1
X
1 (0.454)
K017
Heavy ends (still bottoms) from the purification
column in the production of epichlorohydrin
1 1
1 1
1 1
1 1
1 1
1
1 1*
1
1
1
4
1
| K017
1
1
A
10 (4.54)
KOI 8
Heavy ends from the fractionation column in ethyl
chloride production
1 1
1 1
1 1
1 1
I 1
1
1 1*
1
1
I
4
1
| K018
1
1
1
X
1 (0.454)
K019
Heavy ends from the distillation of ethylene
dichloride in ethylene dichlonde production
1 1
1 1
1 1
1 1
1 1
1 1*
1
1
4
I K019
1
1
I
A
10 (4.54)
K020
Heavy ends from the distillation of vinyl chloride
in vinyl chloride monomer production
1 1
1 1
1 1
1 1
| 1
1
1 1*
1
1
1
4
1
I K020
1
1
A
10 (4.54)
K021
Aqueous spent antimony catalyst waste from
fluoromethanes production
1 1
1 1
1 1
1 1
1 |
1
1 1*
1
1
i
4
1
| K021
1
1
A
10 (4.54)
K022
Distillation bottom tars from the production of
phenol/acetone from cumene
1 1
1 1
1 1
1 1
1 1
I
1 1*
1
1
1
4
1
| K022
1
1
1
X
1 (0.454)
K025
Distillation bottoms from the production of
nitrobenzene by the nitration of benzene
1 1
1 1
1 1
I 1
1
1 1*
1
1
1
4
1
| K025
1
1
B
100 (45.4)
K 027
Centrifuge and distillation residues from toluene
diisocyanate production
1 1
1 1
1 1
1 1
I |
1
1 1*
1
1
1
4
1
| K027
1
1
i
B
100 (45.4)
K028
Spent catalyst from the hydrochlorinator reactor
in the production of 1,1,1-trichloroethane
1 1
1 1
1 1
1 1
1 I
1
1 1*
1
1
|
4
1
I K028
1
1
B
100 (45.4)
K029
Waste from the product steam stripper in the
production of 1,1,1-tnehloroethane
1 1
1 1
1 1
1 1
1 1
1
1 1»
1
1
1
4
1
I K029
I
1
1
B
100 (45.4)
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQL.IST.FOT/12-APR-85 12:16:37
-------
LjST OF
HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES
1 1
- Continued
1 Statutory
1 1
1 1
1 I IRCRA
1 1 1 Waste
Proposed RQ
Hazardous Substance
1 CASRN | Regulatory Synonyms
1 RQ j Code t (Number
Category
Pounds(Kg)
K 030
Column bottoms or heavy ends from the combined
production of trichloroethylene and
perchloroethylene
1 1
1 1
1 I
1 1
1 |
I I 1
I 1* 1 4 | K030
1 1 1
1 1 1
1 1 1
1 1 1
X
1 (0.454)
K 031
By-product salts generated in the production of
MSMA and cacodylic acid
1 1
1 1
1 1
1 1
| |
1 1* 1 4 | K031
1 1 1
1 1 1
1 1 1
X
1 (0.454)
K032
Wastewater treatment sludge from the production of
chlordane
1 1
1 1
1 1
1 I
1 1
1 1 1
1 1* 1 4| K032
1 1 1
1 1 1
1 1 1
X
1 (0.454)
K 033
Wastewater and scrub water from the chlorination
of cyclopentadiene in the production of chlordane
1 1
1 1
1 1
1 1
1 1
1 1 1
1 1* 1 4 | K033
i i i
i i i
i i i
X
1 (0.454)
K 034
Filter solids from filtration of
hexachlorocyclopentadiene in the production of
chlordane
1 1
1 1
1 1
1 1
1 1
1 1
1 1* 1 4| K034
1 1 1
1 1 1
1 1 1
1 1 1
X
1 (0.454)
K03S
Wastewater treatment sludges generated in the
production of creosote
1 1
1 1
1 1
1 1
| I
1 1 1
|1* I 4 1 K035
1 1 1
1 1 1
1 1 1
X
1 (0.454)
K 038
Wastewater from the washing and stripping of
phorate production
1 1
1 1
1 1
1 1
1 i
1 1 1
I 1* I 4| K038
i i i
i i i
i i i
B
100 (45.4)
K040
Wastewater treatment sludge from the production of
phorate
1 1
1 1
1 1
1 I
1 1* 1 4| K040
1 1 1
1 1 1
1 1 1
B
100 (45.4)
K 041
Wastewater treatment sludge from the production of
toxaphene
1 1
1 1
1 1
1 1
1 |
1 1 1
1 1* 1 4| K041
1 1 1
1 1 1
1 1 1
X
1 (0.454)
K 042
Heavy ends or distillation residues from the
distillation of tetrachlorobenzene in the
production of 2,4,5-T
1 1
1 1
1 1
1 1
1 1
1 1
1 1 1
1 1* 1 4 1 K042
1 1 1
1 1 1
1 1 1
1 1 1
A
10 (4.54)
K043
2,6-Dichlorophenol waste from the production of
2,4-D
1 I
1 1
1 1
1 1
1 1
I 1 1
1 1» 1 4| K043
1 1 1
1 1 1
1 1 1
A
10 (4.54)
RQLIST/CARC0485A.DTB/CON RQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1 1
1
Statutory
1 1
1 1
1
1
RCRA
Waste
Proposed RQ
Hazardous Substance
1 CASRN I
Regulatory Synonyms
1 RQ
Code t (Number
Category
Pounds(Kg)
K 048
Dissolved air flotation (DAF) float from the
petroleum refining industry
1 1
1 1
1 1
1 1
1 |
1
1 1«
1
1
1
4
K048
A
10 (4.54)
K 049
Slop oil emulsion solids from the petroleum
refining industry
1 1
1 1
1 1
1 1
i |
1 1*
1
1
1
4
K049
A
10 (4.54)
K 050
Heat exchanger bundle cleaning sludge from the
petroleum refining industry
1 1
1 1
1 1
1 1
j j
I
1 1*
1
1
1
4
K050
A
10 (4.54)
K 051
API separator sludge from the petroleum refining
industry
1 1
1 1
1 1
1 1
1 1*
1
1
i
4
K051
A
10 (4.54)
K 060
Ammonia still lime sludge from coking operations
1 1
1 1
1 1
1 i
1
1 1*
1
I
4
K060
X
1 (0.454)
K061
Emission control dust/sludge from the primary
production of steel in electric furnaces
1 1
1 1
1 1
1 1
1 1
I
1 1*
1
1
i
4
K061
A
10 (4.54)
K062
Spent pickle liquor from steel finishing operations
1 1
1 1
1 1
1 1
1
1 1*
1
i
4
K062
A
10 (4.54)
K 069
Emission control dust/sludge from secondary lead
smelting
1 1
1 1
1 1
1 1
j j
I
1 1»
1
1
1
4
K069
A
10 (4.54)
K 073
Chlorinated hydrocarbon waste from the
purification step of the diaphragm cell process
using graphite anodes in chlorine production
1 1
1 1
1 1
1 1
1 |
1 1*
1
1
1
1
4
K073
A
10 (4.54)
K0B4
Wastewater treatment sludges generated during the
production of veterinary pharmaceuticals from
arsenic or organo-arsenlc compounds
1 1
1 1
1 1
1 1
1 1
1 1
I
1 1*
1
1
1
1
4
K084
X
1 (0.454)
K 085
Distillation or fractionation column bottoms from
the production of chlorobenzenes
1 1
1 1
1 1
1 1
1 1
1
1 1*
1
1
1
4
K085
A
10 (4.54)
RQLIST/CARC04 85A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
1 1
1
Statutory
1 1
1 1
1
1
I RCRA
1 Waste
Proposed RQ
Hazardous Substance
1 CASRN I
Regulatory Synonyms
1 RQ
Code t [Number
Category
Pounds(Kg)
K086
Solvent washes and sludges, caustic washes and
sludges, or water washes and sludges from cleaning
tubs and equipment used in the formulation of ink
from pigments, driers, soaps, and stabilizers
containing chromium and lead
1 1
1 1
1 1
1 1
1 1
1 1
1 1
I i
1 1*
1
1
1
1
1
i
1
4 I K086
1
1
1
1
1
i
A
10 (4.54)
K 095
Distillation bottoms from the production of 1,1,1-
trichloroethane
I I
1 1
1 1
1 1
1 i
1
1 1»
1
1
i
1
4 | K09S
1
1
¦
A
10 (4.54)
K096
Heavy ends from the heavy ends column from the
production of 1,1,1-trichloroethane
I I
1 1
1 1
1 1
1 i
1
1 1»
1
1
I
4 I K096
1
1
I
B
100 (45.4)
K 097
Vacuum stripper discharge from the chlordane
chlorinator in the production of chlordane
1 1
1 1
1 1
1 1
1 1
I
1 1*
1
1
i
4 | K097
1
1
i
X
1 (0.454)
K098
Untreated process wastewater from the production
of toxaphene
1 1
1 1
1 1
1 1
I |
1
1 1*
1
1
1
1
4 | K098
1
1
1
X
1 (0.454)
K099
Untreated wastewater from the production of 2,4,-D
1 1
1 1
1 1
1 1
1
1 1*
1
1
1
4 I K099
1
A
10 (4.54)
K100
Waste leaching solution from acid leaching of
emission control dust/sludge from secondary lead
smelting
1 I
1 1
1 1
1 1
1 1
I
1 1*
1
1
1
i
1
4 I K100
1
1
1
i
A
A
10 (4.54)
10 (4.54)
K101
Distillation tar residues from the distillation of
aniline-based compounds in the production of
veterinary pharmaceuticals from arsenic or organo-
arsenic compouncte
1 1
1 1
1 1
1 1
1 1
1 1
1
1 1*
1
1
1
1
1
i
4 | K101
1
1
1
1
¦
X
1 (0.454)
K102
Residue from the use of activated carbon for
decolorization in the production of veterinary
pharmaceuticals from arsenic or organo-arsenic
compounds
1 1
1 1
1 1
1 1
1 1
1 1
1 |
1
1 1*
1
1
1
1
1
1
4 I K102
1
1
1
1
X
1 (0.454)
K104
Combined wastewater streams generated from
n 11 robe n ze ne/a n 111 n e chloroben ze nes
1 1
1 1
1 1
1 1
1 1
I
1 I*
1
1
1
1
4 | K104
i
i
i
B
100 (45.4)
RQLIST/CARC0485A.DTB/CONRQL1ST.HED/CON RQLIST.FOT/12-APR-85 12:16:3?
-------
LIST OF HAZARDOUS SUBSTANCES AND REPORTABLE QUANTITIES - Continued
Hazardous Substance
1 1
I 1
1 1
I CASRN I
Regulatory Synonyms
1
1
1
1 RQ
Statutory |
1RCRA|
1 Waste I Proposed RQ
Code t |Number|Category I Pounds(Kg)
K1 OS
Separated aqueous stream from the reactor product
washing step in the production of chlorobenzenes
1 1
1 1
1 1
1 1
1 1
1 1*
1
1
1
1 1 1
4 I K105 | A 1 10 (4.54)
1 1 1
1 1 1
1 1 1
1»
S
indicates the statutory source as defined by 1, 2, 3 or 4 below
no reporting of releases of this hazardous substance is required if the diameter of the pieces of the solid
metal released is equal to or exceeds 100 micrometers (0.004 inches)
the RQ for asbestos is limited to friable forms only
indicates that the statutory source for designation of this hazardous substance under CERCLA is
indicates that the statutory source for designation of this hazardous substance under CERCLA is
indicates that the statutory source for designation of this hazardous substance under CERCLA is
indicates that the statutory source for designation of this hazardous substance under CERCLA Is
indicates that the 1-pound RQ is a CERCLA statutory RQ
the Agency may adjust the RQ for radionuclides in a future rulemaking; until then the statutory 1-pound RQ applies
CWA Section
CWA Section
CAA Section
311(b)(4)
307(a)
112
RCRA Section 3001
RQLIST/CARC0485A.DTB/CONRQLIST.HED/CONRQLIST.FOT/12-APR-85 12:16:37
-------
The Agency ranks each intrinsic property, except potential carcinogenicity
(see p. 2-36), on a five-tier scale, associating a specific range of values on
each scale with a particular RQ value. This five-tier scale uses the five RQ
levels of 1, 10, 100, 1000, and 5000 pounds, which were originally established
pursuant to the CWA Section 311. Each hazardous substance receives several
tentative RQ values based on its particular properties. The lowest of all of
the tentative RQs becomes the primary criteria RQ for that hazardous
substance. For example, if substance A is evaluated for aquatic toxicity and
mammalian toxicity, and RQs of 100 pounds and 1000 pounds are set for aquatic
toxicity and mammalian toxicity, respectively, the 100-pound value will be the
applicable primary criteria RQ. Thus, the overall methodology for adjusting
RQs consists of associating the intrinsic properties of the hazardous
substances with the RQ levels and selecting the lowest level to arrive at the
primary criteria RQ.
Other Factors
Upon completion of the evaluation and the establishment of a primary criteria
RQ, other factors may then be applied. The other factors are the natural
degradative processes of biodegradation, hydrolysis, and photolysis (BHP).
The rationale for applying BHP is that certain hazardous substances, when
released into the environment, may degrade through one or more of these
processes into less hazardous or Innocuous products. If such is determined to
be the case, the applicable primary criteria RQ is subsequently adjusted
upward one RQ level. This adjustment reflects the Agency's judgment that the
danger posed by the release of certain hazardous substances may be reduced due
to these degradative processes. The upward adjustment for potential
carcinogens is restricted, however, in order to maintain a 100-pound maximum
RQ value on all potential carcinogens. For example, the hazardous substance
formaldehyde is subject to biodegradation based on reported BOD data (see
Appendix A). However, since its primary criteria RQ is already 100 pounds on
the basis of its potential carcinogenicity ranking (in addition to its chronic
2-28
-------
toxicity and ignitability rankings) formaldehyde is not a candidate for upward
adjustment of its primary criteria RQ based on its biodegradability. This
logic is consistent with the other primary criteria scales which do not allow
an RQ above 5000 pounds even if substances with 5000-pound RQs exhibit BHP
characteristics.
Appendix A summarizes the results of the review for candidate hazardous
substances for BHP adjustments. It lists the biodegradation, hydrolysis and
photolysis data that are available, identifies those substances rejected on
the basis of bioaccumulation, persistence, reactivity, or hazardous
degradation products, and indicates those hazardous substances for which no
data or insufficient information are available to make an evaluation. Table
2-2 presents the final candidates, four in number, for which sufficient data
are available to justify an upward RQ adjustment ( one level) on the basis of
one or more of the BHP processes. Also shown in the table are the original
primary criteria RQ assignments and the basis on which those assignments were
made.
In some cases, the processes of BHP may produce other hazardous substances
which could lead to increased danger to public health and welfare, and the
environment after a release has occurred. The Agency has taken this into
account whenever such hazardous degradation products are known. In
particular, when assessing reactivity during the primary criteria analysis,
hazardous substances which can hydrolyze to yield hydrofluoric acid, hydrogen
sulfide, or phosphine have been assigned reactivity RQs on the basis of these
hazardous products. In this current group of 260 hazardous substances, the
only substance meeting this reactivity criterion is sulfur selenide, which is
also a potential carcinogen.
A number of hazardous substances (diethylarsine, phenyldichloroarsine, and
cacodylic acid) were ranked as potential carcinogens on the basis of their
degradation in the environment to potential carcinogenic products. One
potential carcinogen (3,3'-dichlorobenzidine) had its RQ lowered because of
2-29
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Table 2-2. FINAL CANDIDATE LIST FOR UPWARD RQ ADJUSTMENTS
BASED ON OTHER FACTORS (BHP)
Primary Proposed
Basis for Adjustment Criteria RQ RQ
Hazardous Substance B* H* P* (Pounds) Basis (Pounds)
Bis(chloromethyl) X 1 CARC 10
ether*
Chloromethyl methyl X 1 CARC 10
ether
Dimethyl sulfate X 10 CARC=c 100
2-Naphthylamine X 10 CARC 100
NOTES:
*B - refers to biodegradation.
*H - refers to hydrolysis.
*P - refers to photolysis.
ABBREVIATIONS:
CARC - Potential carcinogenicity
CARC=c - Carcinogen hazard ranking will be possible when methodology
to calculate a reasonable potency factor is developed
or new data become available. (See footnote "c" in
the Summary Table of Appendix B.) An administrative
RQ assignment of 10 pounds has been recommended
for these substances (see p. 2-41).
2-30
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degradation in the environment to a more potent carcinogen (benzidine). The
manner in which RQs have been assigned to these hazardous substances is
covered in more detail later under the discussion of the results of the
carcinogenicity ranking.
Status of Hazardous Substances Designated Under the CWA Section 311
Of the 260 hazardous substances assigned proposed RQs in this report, 72 were
originally listed as hazardous substances and given RQs under the CWA Section
311 (AO CFR Parts 116 and 117). The results of adjustments of the RQs of
these 72 hazardous substances is as follows: 15 RQs remain the same, 56 RQs
are lower, and one RQ is raised.
RQs for the F- and K- Hazardous Waste Streams
Hazardous waste streams as defined in the Resource Conservation and Recovery
Act (RCRA) (also called The Solid Waste Disposal Act of 1976) regulations,
40 CFR Sections 261.31 and 261.32, are commonly called the "F-" and "K-"
hazardous waste streams. These letters refer to the prefixes used in the EPA
identifying hazardous waste number. A total of 69 such waste streams are
being evaluated and assigned RQs in this additional group of hazardous
substances. The procedure for assigning RQs to hazardous wastes based on
their components is described in the paragraphs that follow.
The K- hazardous waste streams are hazardous wastes from specific sources
(e.g., K087 is decanter tank car sludge from coking operations). In order to
assign proposed RQs to these waste streams, each hazardous constituent is
examined. The next step is to identify the RQ associated with each hazardous
constituent and then assign an RQ to each waste stream. The waste stream RQ
will be the lowest RQ associated with the individual hazardous constituents of
the waste stream.
2-31
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The RCRA waste streams F001 - F005 are collective listings (e.g., five
solvents which are hazardous wastes are listed collectively under F005). RQs
are assigned to these waste streams using a special procedure, as follows.
RQs are first assigned to each individual solvent which is a hazardous waste
as in the case of the K- wastes. Then in addition, a generic RQ is assigned
to the several hazardous wastes, equal to the lowest RQ assigned to any of
these individual solvents. If the releaser is unsure which solvent he has
released, or if he has released a mixture of solvents, he will use the generic
RQ for notification purposes.
RQs for Unlisted Hazardous Wastes
The Characteristic of Extraction Procedure (EP) Toxicity was designed to
identify wastes that could be likely to contribute to contamination of
groundwater by leaching from landfills. There are only 14 hazardous
substances for which the EP toxicity characteristic can be determined, as
listed in the RCRA regulation, 40 CFR Section 261.24. Six of these are
specific compounds and eight, while nominally listed as metals, must actually
be determined on the basis of some soluble compound of the metals. A detailed
discussion of the assignment of RQs based on the Characteristic of EP Toxicity
is given in the "Technical Background Document to Support Rulemaking Pursuant
to CERCLA Section 102, Volume 1," March 1985.
The list of hazardous substances and proposed RQs in Table 2-1 includes six
components of the Characteristic of EP Toxicity under the Unlisted Hazardous
Wastes. These six are: arsenic, cadmium, and chromium, which have been
assigned RQs of 1, 10, and 10 pounds respectively, on the basis of potential
carcinogenicity; lead, which has been assigned an RQ of 100 pounds on the
basis of chronic toxicity; and lindane and toxaphene, both of which have been
assigned RQs of 1 pound on the basis of their original CWA Section 311
assignment (i.e., on the basis of aquatic toxicity).
2-32
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RQs Based on Potential Carcinogenicity Rankings
The health, welfare, and environmental factors used to assign RQs using the
primary criteria may be classified into two categories:
1. Those criteria characterized by some acute or immediate threat;
2. Those criteria characterized by a threat that is not immediately
identifiable.
The first category, those criteria characterized by some acute or immediate
threat to human health, welfare, or the environment, are visibly identifiable
in fatal poisonings of mammals or aquatic organisms, or in fires, explosions
or violent reactions. The criteria that readily consider such acute threats
are acute aquatic toxicity, acute mammalian toxicity (oral, dermal,
inhalation), ignitability, and reactivity. The second category of factors
used to assign RQs are characterized by threats to human health or welfare
that are not immediately identifiable. An example of such a threat is the
concern about asbestos as the potential agent underlying current health
problems in persons exposed to asbestos fibers for prolonged periods, such as
shipyard workers in the 1940s. The criteria of chronic toxicity and potential
carcinogenicity have been examined to evaluate hazardous substances such as
asbestos, which may exhibit toxic threats even after a long lapse of time
between exposure and manifestation of the toxicity, or which may induce some
damaging effects as the result of prolonged exposure at doses which are less
than lethal.
Under CERCLA Section 101(14), 705 hazardous substances are designated
including 97 RCRA waste streams. It would be both costly and time-consuming
for the Agency to analyze each one of these hazardous substances to determine
its chronic toxicity and/or potential carcinogenicity because of the complex
analyses required for these criteria. As a result, the CERCLA Section 101(14)
list of hazardous substances was initially reviewed to identify those
hazardous substances that may exhibit chronic toxicity and/or potential
2-33
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carcinogenicity. The Environmental Criteria and Assessment Office (ECAO)
located in Cincinnati, Ohio, has performed the assessments of those hazardous
substances suspected of exhibiting chronic toxicity. Known and potential
human carcinogens have been evaluated by the Carcinogen Assessment Group (CAG)
to determine the substance's carcinogenic hazard ranking. Both of the
organizations are part of the Agency's Office of Health and Environmental
Assessment (OHEA).
The ECAO's evaluation of chronically toxic hazardous substances was discussed
in detail in the "Technical Background Document to Support Rulemaking Pursuant
to CERCLA Section 102, Volume 2," March 1985. The identification of potential
carcinogens and their ranking by CAG are discussed in the paragraphs that
follow.
Identification of Chemical Carcinogens on the CERCLA Section 101(14) List—
In order to identify those CERCLA Section 101(14) hazardous substances which
should be the subject of a detailed potential carcinogenic hazard ranking
assessment, lists of substances suspected of human carcinogenic potential were
examined by CAG to ascertain the existence of human epidemiological data
and/or animal bioassay data which would be indicative of possible carcinogenic
activity. The sources of the lists of known human or potential human
carcinogens that were reviewed include the following:
1. "First Annual Report on Carcinogens." This report was issued in July
1980 by the Department of Health and Human Services (DHHS). It was
prepared by the National Toxicology Program, U.S. Public Health
Services. It lists 26 substances, classes of substances, processes,
and byproducts which "have been reviewed by panels of international
experts and initially found to be associated with the induction of
cancer in man." This report was mandated under an amendment to
Section 301(b)(4) of the Public Health Service Act, Public Law
95-622, signed November 8, 1978.
2. "Second Annual Report on Carcinogens." This report (December 1981)
was also issued by DHHS as required by the Public Health Service Act
(see 1, above). It lists 88 substances, classes of substances,
processes, and byproducts which are "known human carcinogens and
substances which may reasonably be anticipated to cause cancer in
humans." All but one of the substances listed in the First Annual
2-34
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Report were repeated in this Second Report (The substance dropped,
chloramphenicol, is not on the CERCLA Section 101(14) list).
3. "Third Annual Report on Carcinogens" Summary. NTP 82-830. This
report (September 1983) is the third in the series by the DHHS, as
required by the Public Health Services Act. It lists 28 substances,
not identified in the two prior reports, which are "known
carcinogens" or "which may reasonably be anticipated to be
carcinogens."
4. "Monographs Supplement 1. Chemicals and Industrial Processes
Associated with Cancer in Humans." This report was issued September
1979 by the International Agency for Research on Cancer (IARC). It
encompasses the results of a special working group established to
re-evaluate all prior IARC assessments to determine where studies
identifying carcinogens met IARC's newer evaluation criteria. The
report lists 142 substances and classes of substances for which there
is "sufficient evidence of carcinogenicity in experimental animals."
5. "Monographs Supplement 4. Chemicals, Industrial Processes and
Industries Associated with Cancer in Humans." This report was issued
in 1982 by the IARC and is essentially an updated version of
Monographs Supplement 1. This report lists 175 substances and
classes of substances for which there is "sufficient evidence of
carcinogenicity in experimental animals." It further evaluates the
risk to humans for a total of 154 chemicals, processes or industries.
The above lists were compared with the CERCLA Section 101(14) list to
determine which CERCLA Section 101(14) hazardous substances should be
evaluated by CAG. After a review by CAG, it was decided that all such
potential carcinogens would be included on the list to be evaluated,
regardless of whether other primary criteria had already resulted in 1-pound
RQs. CAG wanted to include all such hazardous substances in order to test the
relative manner in which new or modified methodologies would rank them.
A total of 185 hazardous substances on the CERCLA Section 101(14) list were
thus identified as potential carcinogens and have been evaluated by CAG in a
detailed carcinogenic relative ranking assessment (see Appendix B). Some of
these hazardous substances are not specifically mentioned in the references
cited above, but were identified because they are members of some particular
class of chemical compounds. For instance, the "First Annual Report on
2-35
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Carcinogens" lists arsenic and arsenic compounds, cadmium and cadmium
compounds, nickel and nickel compounds, chromium and chromium compounds, and
soots, tars, and carbon black, the latter with the active agents identified as
"polycyclic aromatic hydrocarbons." As a result, all those CERCLA Section
101(14) hazardous substances which fell into any of these classes were
submitted to CAG for review and a detailed assessment.
CAG's Ranking Methodology for Potential Carcinogens—
The CAG has formulated a unique ranking methodology for assessing CERCLA
Section 101(14) hazardous substances. The CAG methodology for evaluating
potential carcinogenicity as a primary criterion is neither a risk assessment
nor does it provide any absolute measure of harm. It is simply a methodology
for sorting a list of potentially carcinogenic substances into levels of
relative carcinogenic rank, which may then be equated to RQ levels. It is
essential to stress that this approach simply ranks known human and potential
human carcinogens to obtain a "trigger" applicable for implementing the
statutory notification provisions of CERCLA Section 103.
The CAG ranking procedure examines all information available in the scientific
literature on known human and potential human carcinogens and then applies
this information in a two-phase process. The first phase is qualitative,
wherein the reliability of the available data is evaluated through use of the
IARC classification system. The second phase is quantitative, and is designed
to determine how potent a carcinogen may be. This allows carcinogens to be
compared on a numerical basis, and those hazardous substances inducing cancer
at the lowest doses can be identified as the most hazardous. These two
factors are then combined to form a final ranking for each of the CERCLA
Section 101(14) hazardous substances that were evaluated. A short description
of CAG's ranking procedure follows. A more detailed treatment of the
methodology can be found in Appendix B.
2-36
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In the qualitative phase, to evaluate quality and reliability of the available
data, the IARC classifications for assessing the "strength of evidence" were
used as guidelines. The IARC classifies data as either "sufficient,"
"limited," or "inadequate"; it takes into consideration both human
(epidemiology) and animal (bioassay) data; and it categorizes substances into
four "strength of evidence" groups, as follows (the working definitions of the
strength of evidence categories are given in Appendix B):
IARC
Data Class
Evidence Group Human Animal
1 Sufficient Sufficient, Limited, or Inadequate
2A Limited Sufficient or Limited
2B Inadequate Sufficient or Limited
3 Inadequate Limited or Inadequate
In the quantitative phase, to compare carcinogenic potencies, the Agency's
linearized multistage model is first applied to extrapolate the available data
to low doses. The point on this extrapolated line associated with a lifetime
cancer risk of 10% is then determined, and the estimated dose (ED^q) at this
point is used to determine a potency factor, F, where F = 1/ED^q. Based on
the F factors, each evaluated substance is placed in a potency group (Group 1,
2, 3, or 4), as shown below:
Potency Group
1
2
3
4
Potency Factor Range
> 100
10-100
1-10
< 1
The net result of this procedure is the classification of hazardous substances
into four groups. Those hazardous substances with relatively high potencies
and which would have the potential to induce cancer at relatively low doses
2-37
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are classified in Group 1. Other hazardous substances with lower potencies
are placed into Groups 2, 3, and 4. Group 4 includes the hazardous substances
of lowest potency and which would require a relatively high dose in order to
induce cancer.
The final step in the ranking procedure is to combine both the qualitative
IARC Evidence Group and the quantitative Potency Group factors to yield a
relative ranking for each CERCLA Section 101(14) hazardous substance selected
for this evaluation. The three relative ranking groups are simply identified
as "high," "medium," or low," and are determined as shown in Table 2-3.
It should be noted that CAG's carcinogenicity ranking scheme does not in
itself yield an RQ; rather, it ranks a hazardous substance's carcinogenic
potency as "high," medium," or "low." RQ levels have been assigned to these
three relative rankings as follows:
RQ Category RQ (Pounds) Hazard Rank
X 1 High
A 10 Medium
B 100 Low
C 1000
D 5000
This approach places highly potent known human or potential human carcinogens
at the 1-pound RQ level.
Results of the Carcinogenicity Ranking—
The detailed results of the CAG assessment of the 185 CERCLA Section 101(14)
hazardous substances appear in the Summary Table of Appendix B. The 5
potential carcinogens assessed by CAG, but not listed in Appendix B are:
Benzotrichloride, bis (2-ethylhexyl)phthalate, formaldehyde, 2-nitropropane,
and sulfur selenide. A summary table for these substances is provided in
Appendix C. The available data allow the assignment of high, medium, or low
rank to 149 of the 185 hazardous substances. The CAG methodology is thus
being used to assign a direct rank for potential carcinogenicity to 149
2-38
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Table 2-3. CARCINOGEN RANKING SCHEME
Potency Group
IARC Group 12 3 4
1
High
High
Medium
Low
2A
High
Medium
Medium
Low
2B
High
Medium
Low
Low
3
No direct
*
ranking possible
*
Two types of substances fall into this category:
1. Those which are known to be carcinogens, but which can not be ranked
because of insufficient quantitative data.
2. Those which are adjudged not to be carcinogens, and whose RQs should
accordingly be assigned on the basis of other SCP factors.
2-39
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individual substances (excluding the waste streams). Some were assigned RQs
of 1, 10, or 100 pounds, based directly on the CAG rankings of high, medium,
or low. For others, the RQs were assigned indirectly, based on administrative
considerations, or on special situations related to the chemistry of the
hazardous substance. The results of these tentative
-------
Substances Only Qualitatively Identified as Carcinogens—For 19 of the
hazardous substances, there is either sufficient or limited data that shows
them to have a potential carcinogenic effect, but not enough quantitative
information about the associated doses to allow a potency factor to be
estimated. (These substances are identified with the footnote "c" in the
Summary Table of Appendix B, as well as in Table 3-1). An administrative RQ
assignment of 10 pounds has been recommended for these substances, with one
exception. The proposed RQ for the substance 2,6-dinitrotoluene is 100 pounds
because the CAG methodology resulted in a direct 100-pound assignment ("low"
ranking) for the isomeric 2,4-dinitrotoluene. The decision to use the
10-pound level is based on the fact that the majority of the substances that
could be ranked by the CAG methodology were assigned the "medium" (10-pound)
ranking.
Known Carcinogen Not Rankable by CAG Methodology—Asbestos. The CAG procedure
cannot be used to determine a relative ranking for asbestos, even though
asbestos has been identified as a known human carcinogen. The method for
measuring exposures to asbestos is based on the size and number of airborne
fibers, and not on the classical method of measuring dose based on weight,
volume, or concentration, so the CAG methodology cannot be applied. Since no
direct ranking is possible, a decision has been made to include asbestos in
the group of hazardous substances assigned an RQ of 10 pounds on an
administrative basis.
Indirect Assignment of RQs for Potential Carcinogens—Beryllium Compounds.
CAG assessed "Beryllium and Compounds" as one of the CERCLA Section 101(14)
hazardous substances, assigning it a medium (10-pound RQ) hazard ranking.
However, the CERCLA Section 101(14) list also includes the specific substances
beryllium chloride, beryllium fluoride, and beryllium nitrate. Even though
these hazardous substances were not specifically ranked by CAG, they have each
been assigned a 10-pound RQ as members of the "Beryllium and Compounds" class.
2-41
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Aroclor Compounds. CAG assessed "Polychlorinated Biphenyls (PCBs)" as one of
the CERCLA Section 101(14) hazardous substances assigning it a medium
(10-pound RQ) hazard ranking. However, the CERCLA Section 101(1A) list also
includes seven specific PCBs (Aroclors 1016, 1221, 1232, 1242, 1248, 1254, and
1260). Even though these hazardous substances were not specifically ranked by
CAG, they have each been assigned a medium (10-pound RQ) hazard ranking.
Organic Arsenic Compounds. Three organic arsenic compounds are on the CERCLA
Section 101(14) list: cacodylic acid, dichlorophenylarsine, and
diethylarsine. CAG found no qualitative or quantitative evidence to allow
these hazardous substances to be ranked as carcinogens. However, all three of
these are degraded to inorganic arsenic oxides if released to the environment.
Accordingly, it has been judged appropriate to assign each of these substances
a "high" ranking (1-pound RQ) based on other inorganic arsenic oxides which
are assigned 1-pound RQs. This assignment is consistent with the chemistry of
the hazardous substances and follows CAG's suggestion that environmental fate
and transport data be applied when appropriate. (See page B-31 of Appendix
B).
3,3'-Dichlorobenzidine. The CAG methodology ranks 3,3'-dichlorobenzidine as
"low", leading to an RQ assignment of 100 pounds. However, in reviewing
substances for BHP adjustments, it was found that 3,3'-dichlorobenzidine is
subject to rapid photolysis if released into the environment, yielding
benzidine itself as one of the photolysis products. The RQ of
dichlorobenzidine was accordingly reduced to that of the more potent benzidine
(ranked "medium" by CAG, and assigned a 10-pound RQ).
This CAG ranking technique in conjunction with the other criteria for
assigning RQs results in the proposed RQs listed in Table 2-1. This procedure
produces the RQ adjustments summarized on p. 1-2.
2-42
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A COMPARISON OF CHRONIC TOXICITY AND POTENTIAL CARCINOGENICITY AS PRIMARY
CRITERIA
Chronic toxicity rankings for chemical substances are derived from the
consideration of dose-dependent adverse effects. Adverse effects are defined
as any effects that result in functional impairment and/or pathological
lesions that may either affect the performance of an organism or reduce its
ability to combat additional insult. An increased dose of such substances
leads to a more pronounced effect, or an increasing number of effects.
Correspondingly, a decreased dose will lead to a less pronounced effect, or a
decreasing number of effects, until a No Observed Effect Level (NOEL) is
reached. Chemical substances acting in this manner may be considered
threshold agents, since the organism can tolerate continuing exposure to the
substance, and either eliminate the substance or marshall its defenses against
the substance in such a manner that it suffers no harm. Conventional
toxicological methods have long been available to define "safe levels of
exposure" to these agents. Thus, conventional toxicological methods can be
used in ranking systemic toxicants.
Carcinogenic substances, on the other hand, give dose responses which are
consistent with no threshold in general. Therefore, "safe levels of exposure"
cannot be identified. This difference arises because cancer seems to be
different from other health problems. It is multifactor In its causation and
multistage in its development. First, cancer appears often to be a disease of
DNA damage, misrepair, or incomplete repair. There is evidence that only a
few molecules of a carcinogen are needed to induce DNA damage. Second, cancer
is a progressive process with long latencies (as much as ten to 20 years in
man). Once the final stage of carcinogenesis has started, the transformed
cells appear to self-replicate out of control of normal growth processes.
When parts of this cell mass invade neighboring tissue directly or are
transferred to distant sites through the circulatory system (a process known
as metastasis), malignant tumors (cancer) result. The initiating agent need
not be present once the process has begun. Third, many agents seem to induce
2-43
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the same cancer. Thus carcinogens should not be considered in isolation
because carcinogens can act additively, at least, to produce the same tumor.
For the sake of argument, assume that a threshold dose exists for each
carcinogen. Even though the individual dose for each substance might be below
its respective threshold dose, the summation of doses for several substances
acting simultaneously might exceed the threshold for the individual organism.
Moreover, the sensitivity of individual organisms of the same species is
different. Therefore, meaningful (practical) thresholds cannot be established
even if they do exist for these agents.
Mathematical models have been developed to estimate the magnitude of harm
associated with exposure to various "non-threshold" agents. Thorough
discussions of these models, their biologic basis and uncertainties and
limitations associated with their use can be found in the published
literature. This brief discussion is intended to give the reader an
appreciation that non-conventional toxicological methods are more appropriate
in evaluating the magnitude of harm posed by carcinogens. It describes the
CAG methodology for ranking potential carcinogens and the application of this
methodology to assign RQs is compared to the chronic toxicity RQ assignments.
A step-wiee process is employed in ranking suspected carcinogens. First, the
biomedical evidence regarding the likelihood of an agent as a potential human
carcinogen is stratified using the IARC criteria. Second, on the assumption
that the agent is a potential human carcinogen, a quantitative estimate of the
strength (a potency factor) of the agent as a potential human carcinogen is
determined using an appropriate extrapolation model. Coupling the qualitative
"weight-of- evidence" to the "potency factor" allows a systematic ranking of
suspected carcinogens.
The final difference between the chronic toxicity and the potential
carcinogenicity as primary criteria is in the RQ levels assigned. The chronic
toxicity procedure theoretically leads to classifying substances into the
usual five RQ levels (although in actuality no substances were adjudged to
2-44
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have a strong enough adverse effect at a low enough effective dose to place
any chronic toxicant at the 1-pound RQ level). Even though the potential
carcinogenicity procedure could be adapted to yield five levels of ranking,
only three were assigned which are tentatively expressed as the 1-, 10-, and
100-pound RQ levels, leaving the 1000-pound and 5000-pound levels unused.
Restricting potential carcinogen rankings to the three lowest levels is simply
an administrative decision to support a more conservative position in
protecting the public and the enviroment from potential carcinogenic agents.
Because of these fundamental differences, it is appropriate that different
ranking procedures be applied for ranking chronic toxicity and
carcinogenicity, even though carcinogenicity might be considered as a form of
chronic toxicity. While a superficial similarity exists in that both methods
use some measure of effective dose level as one factor in developing an
overall ranking, the relationship between dose and response is different in
the two. Dose as applied to chronic toxicity rankings is related to the
intensity or extent of the toxic manifestations. Dose as applied to
carcinogenicity is related to the probability that cancer will occur.
2-45
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SECTION 3
DATA TABLES FOR HAZARDOUS SUBSTANCES
Detailed data tables showing the data for the primary criteria, the proposed
RQs and the basis for the proposed RQs are presented in Table 3-1. The tables
include the data on aquatic toxicity, mammalian toxicity (oral, dermal, and
inhalation), chronic toxicity, potential carcinogenicity, ignitability, and
reactivity upon which the choice of the proposed RQ is based.
Data entered in the Aquatic Toxicity, Mammalian Toxicity, Chronic
Toxicity/Carcinogen, and Ignitability/Reactivity columns are followed by a
letter (X, A, B, C, or D) indicating the RQ level corresponding to that
particular data point. The numerical value corresponding to the lowest level
so identified is given in the proposed RQ column.
All notes listed in the table are located at the end of this section, and all
abbreviations used are discussed there in some length. For those not concerned
with the complete development of the data in Table 3-1, the most common
abbreviations are as follows:
(X),(A),(B),(C),(D) - RQ Categories 1, 10, 100, 1000, and 5000
pounds, respectively
311 - The RQ was established on the basis of aquatic
toxicity under the regulations from the
CWA Section 311.
AQTX - Aquatic toxicity (other than a CWA Section 311
assignment).
T(orl) - Mammalian toxicity (oral)
T(ihl) - Mammalian toxicity (inhalation)
T(skn) - Mammalian toxicity (skin, or dermal)
CTX - Chronic toxicity
3-1
-------
CARC - Potential carcinogenicity
F - Flash point (°F)
B - Boiling Point <°F)
I - Ignitability
R - Reactivity
CS - The RQ was assigned on the basis of chemical similarity
to another hazardous substance, in the absence of data
for the primary criteria.
Max - Maximum possible RQ assignment
BHP - Biodegradation, hydrolysis, or photolysis
- The lowest reported dose which has caused death.
LC^q - The lowest reported concentration which has caused death.
CARC=c - A carcinogen hazard ranking will be possible when
methodology to calculate a reasonable potency factor is
developed or new data become available. (See footnote "c"
in the Summary Table of Appendix B.) An administrative
RQ assignment of 10 pounds has been recommended for these
substances (see p. 2-41).
3-2
-------
Table 3-1
DATA FOB THE NPRM HAZARDOUS SUBSTANCES
Hazardous Substance (Note 1)
1 1
1 1 Aquatic
1 1 Toxicity
1 CASRN I (Note 2)
1
1
1
| Mammalian Toxicity
(Note 3)
1 Chronic
1 Toxicity/
1 Carcinogen
1 (Note 1)
Ignitability/
leactivity
(Note 5)
311
RQ
(Note 6)
Proposed
RQ
(Note 7)
I
I Basis for
IProposed RQ
I (Note 8)
Comments
Acetaldehyde, trichloro-
1 1
1 758761
1 1
1
iRbt-orl:180(D)
1
I
1
|[CT=16(A)]
ICT=I.D.
I
5000
I
iT(orl)
I
I
Note 21
Acetamide, H-(U-ethoxyphenyl)-
| |
1 624421
1 i
1
|Rat-orl:1650(D)
t
1
ILOW 100
1
Solid
100
I
ICARC
1
Acetamlde, N-9H-fluoren-2-yl-
i i
1 539631
1 i
1
iMus-orl:1020(D)
1
1
IMED 10
¦
Solid
10
I
ICARC
1
Acetic acid, lead salt
i l
1 3010421500-100(0)
1 1
| |
1
lDog-orl:LDLo:300(D)
iDog-orl:300(D)
t
1
ILOW 100
ICT=32(B)
I
Solid
5000
100
I
ICARC,CTX
1
1
Note 10
2-Acetylaminofluorene
1 539631
1 i
1
|Mu3-orl:1020(D)
1
1
IMED 10
1
Solid
10
1
ICARC
1
Acrylonitrile
1 I
1 107131110-KB)
1 1
I
iRat-orl:82(C)
iRat-ihl: 500/1H (D)
I
1
ILOW 100
ICT=30(B)
1
F 32(C)
B 171
100
100
1
I311.CARC,
I CTX
1
Note 9
Alanine, 3-[p-bis(2-
chloroethyl)amino]phenyl-,L-
1 |
1 1488231
1 1
1 1
1
1
1
1
1
IHIGH 1
1
1
Solid
1
1
ICARC
1
1
Aldrln
l I
1 309002K0.KX)
| |
1
lRat-orl:39 (C)
|
1
IMED 10
1
Solid
1
1
1311
1
Note 10
Ami trole
1 618251
1 1
1
IRat-orl: 1100(D)
1
1
ILOW 100
¦
Solid
100
1
ICARC
I
Anmonlun bichromate
I 1
1 77890951100-10 (C)
I I
l 1
1
1
1
1
1
IMED 10
|CT=I.D.
1
Solid
1000
10
1
ICARC
1
1
Note 10
Anmoniimi chromate
1 I
1 77889891100-10(0)
1 1
1
1
1
1
IMED 10
1
Solid
1000
10
1
ICARC
1
Aroclor 1016
1 1
112674112|[<0.1(X)]
I 1
1
1
1
1
IMED 10
1
10
1
1
lAQTX
|
Note 11
Aroclor 1221
1 1
111104282ll<0.1(X)]
1 1
1
IRat-orl:3980(D)
1
1
IMED 10
1
10
1
1
lAQTX
|
Note 11
Aroclor 1232
1 1
|11141165I[<0.1(X)]
1 1
I
IRat-orl:4470(D)
1
1
IMED 10
1
10
1
lAQTX
1
Note 11
Aroclor 1212
1 1
1534692191[<0.1(X)]
1 1
1
IRat-orl: 1250(D)
J
1
IMED 10
1
10
1
l
lAQTX
1
Note 11
Aroclor 1218
1 1
1126722961[<0.1(X)]
1
lRat-orl:11 gm/ke(D)
I
1
IMED 10
¦
10
1
1
lAQTX
|
Note 11
Aroclor 1251
1 |
1110976911[<0,1(X)]
1 1
1
IRat-orl: 1010 nig/kg
I
(D)
1
IMED 10
1
10
1
lAQTX
1
Note 11
Aroclor 1260
1 1
1110968251[<0.1(X)]
1 1
1
IRat-orl:1315(D)
1
1
IMED 10
1
10
1
1
lAQTX
|
Note 11
Arsenic tt
1 1
1 71103821
1 1
1 1
1
1
1
1
1
IHIGH 1
ICTrl.D.
I
Solid
1
1
ICARC
1
|
Note 10
Arsenic acid
1 1
1 13275221
1 77783911
1 1
1
IRat-orl: 18(C)
1
1
1
IHIGH 1
|CT=18(C)
I
Solid
1
ICARC
1
1
Note 12
R
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance
(Note 1)
1
1 Aquatic
1 Toxicity
CASRN 1 (Note 2)
1 Mammalian Toxicity (Note 3)
I Chronio |
I Toxici ty/jIgnitabl11ty/
ICarcinogenl Reactivity
1 (Note 4)1 (Note 5)
311
RQ
Note 6)
1
Proposed I Basis for
RQ 1 Proposed RQ
(Note 7)1 (Note 8)
C omenta
Arsenic disulfide
1
1303328I500-100(D)
I
1
1
IHICH 1
ICTsI.D.
1
1
1Sol id
1
|
5000
1
1
ICARC
1
|
Note 10
Arsenic (III) oxide
1327533110-1
I
1
(B)
IMan-orl: KB)
|Rat-orl:20(C)
1
IHIGH 1
|CT=41(A)
1
1
1 Sol id
1
1
5000
1
ICARC
1
|
Note 10
Arsenic(V) oxide
1
1303282110-1
I
1
(B)
|Rat-orl:8(B)
1
IHIGH 1
|CT=19(C)
I
1
1Solid
1
1
5000
1
ICARC
1
|
Note 10
Arsenic pentoxide
1
1303282110-1
I
I
(B)
|Rat-orl:8(B)
1
IHIOT 1
ICT=19(C)
1
1
1SolId
1
|
5000
1
ICARC
1
|
Note 10
Arsenic trichloride
1
778M311110-1
1
1
(B)
iMus-ihl LCLo:338/1(M(C)
1
IHIGH 1
|CT=39(B)
1
IH:NH (d)
1 J
1
5000
1
jCAHC
|
Note 13
Arsenic trloxide
1
1327533110-1
I
1
(B)
IMan-orl: 1(B)
iRat-orl: 20(C)
1
iHICai 1
|CT=41(A)
1
1
1 Solid
1
1
5000
1
ICARC
1
j
Note 10
Arsenic trlsulflde
13033391500-100(D)
I
1
1
IHIGH 1
|CT=35(B)
1
1
1Solid
1
1
5000
1
ICARC
1
|
Note 10
Araine, diethyl-
6921221
1
I
1
iHira 1
|CT=I.D.
1
1
iPyro (A)
1
I
1
ICARC
1
|
Notes 20
27
Asbestos ttt
1
133221HI
1
1
1
ICARC=p
ICT=79(A)
1
1
1Solid
1
1
10
ICTX
1
|
Note 14
Auramine
1
4928081
1
1
IL0M 100
1
1
1 Sol Id
1
100
1
ICARC
1
Azaserine
1
1150261
•1
1515611
I
|
iRat-orl:170(D)
1
|CARC=c
1
i
(Solid
1
10
1
ICARC
1
Note 15
Aziridlne
iRat-orl: 15(C)
iRat-ihl: 25/8H lo(B)
1
IHIGH 1
ICTrl.D.
1
1
I Needs
|stabilizer(B!
1
1
1
ICARC
1
1
Azirino(2' ,3': 3»4)pyrrolo(1,2-a)indole-
14,7-di one, 6-amino-B-
[ ((amino carbonyl )oxy )methyl ]-
1,la,2,8,8a,8b-hexahydro-8a-methoxy-5-
methyl-
1
500771
1
1
1
1
IRat-orl: 14(C)
1
ICARCrc
1
1
1
1
1
1
1Solid
1
1
1
1
1
10
1
ICARC
1
1
1
1
|
Note 15
Benz[J]aceanthrylene,
methyl-
1,2-di hydro-3-
1
561951
1
1
1
IMED 10
I
1
1
1Solid
1
1
10
1
ICARC
1
|
Benz[c]acridine
1
2255111
1
1
IMED 10
1
1
ISolid
1
10
1
ICARC
1
3, 4-Benzacndine
1
2255141
1
1
IMED 10
1
1
1 Solid
1
10
1
ICARC
1
ROTBL/CARC0485A.DTB/CONDATA.HED/12-APR-85 12:16:01
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
I
I Aquatic
I Toxicity
CASRN | (Note 2)
Mammalian Toxicity (Note 3)
I Chronic
I Toxicity/
iCarclnogen
I (Note 4)
Ignitability/
Reactivity
(Note 5)
311
RQ
(Note 6)
Proposed
RQ
(Note 7)
Basis for
Proposed RQ
(Note 8)
Comments
Benz[a]anthracene
I
56553I
I
1
1
IMED 10
|CT=I.D.
I
Solid
10
CARC
1,2-Benzanthracene
1
565531
1
|
1
IMED 10
ICT=I.D.
I
Solid
10
CARC
1,2-Benzanthracene, 7,12-diraethyl-
579761
i
Rat-orl:327(D)
l
IHIGH 1
1
Solid
1
CARC
Benzenamine, 4,4'-earbonimidoylbis (N,N-
dimethyl-
1
1(928081
1
|
1
IL0W 100
I
|
Solid
100
CARC
Benzenamine, 4-chloro-2-methyl-,
hydrochloride
31659331
1
1
ILOW 100
I
I
Solid
100
CARC
Benzenamine, N,N-dimethyl-4-phenylaz»-
1
601171
1
Rat-orl:200(D)
1
IHIGH 1
1
Solid
1
CARC
Benzenamine, 4,4'-methylenebis(2-chloro-
i
1011441
I
1
lLOW 100
i
Solid
100
CARC
Benzenamine, 2-methyl-, hydrochloride
i
6362151
1
Rat-orl: 2951(D)
I
lLOW 100
i
Solid
100
CARC
Benzenamine, 2-methyl-5-nltro-
995581
¦
Rat-orl:574(D)
1
|L0W 100
1
F315
100
CARC
Benzene
1
71132110-1
1
1
(B)
Rat-orl:3800(D)
Rat-ihl:10,000/7H(D)
1
lLOW 100
ICT=17(C)
i
F 12 (C)
B 176
1000
100
AQTX.CARC
Benzene, chloromethyl-
1
1001117110-1
I
I
I
I
I
(B)
Rat-orl:1231(D)
Rat-ihl:150/2H(C)
1
|CARC=C
1
1
1
1
l
F 153(Max)
B 351
Requires
Stabilizer
(B)
100
10
CARC
Notes
15
16
Benzene, hexachloro-
1
1187111
f
i
Rat-orl:10.000(D)
1
IMED 10
ICT=29.5(B)
l
Solid
10
CARC
Note
10
Benzene, 1-methyl-2,4-dinitro-
121112110-100 (C)
I
I
Rat-orl: 268(D)
I
I LOW 100
|CT=32(B)
i
F 404(Max)
B 576
1000
100
CTX, CARC
Benzene, 1-methyl-2,6-dinitro-
l
606202110-100(C)
1
l
Rat-orl:177(D)
1
ICARC=c
|CT=30(B)
I
Solid
1000
100
CARC
Notes
15
29
Benzene, 1,2-methylenedioxy-4-allyl-
915971
|
Rat-orl: 1950(D)
l
lLOW 100
I
F212
100
CARC
Benzene, 1,2-methylenedioxy-M-propenyl-
1205811
|
Rat-orl:1340(D)
I
lLOW 100
I
100
CARC
Benzene, 1,2-methylenedioxy-M-propyl-
945861
|
Rat-orl:2260(D)
1
lLOW 100
I
100
CARC
Benzene, pentaohloronitro-
826881
1
1
Rat-orl:1650(D)
1
lLOW 100
|CT=10.4(C)
I
Solid
I
100
CARC
RQTBL/CARCOH85A.rrrB/COHDATA .HED/12-APR-85 12:16:04
-------
DATA FOB THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
CASRN
Aquatic
Toxicity
(Note 2)
| Mammalian Toxicity (Note 3)
I Chronic
I Toxicity/
1Carcinogen
1 (Note 1)
Ignltabillty/
Reactivity
(Note 5)
311
RQ
(Note 6)
1
Proposed| Basis for
RQ I Proposed RQ
(Note 7)1 (Note 8)
Caranents
Benzene, (trlchlorcmethyl )-
98077
iRat-lhli 125/1H(C)
1
IMED 10
I
? 260
10
I
ICARC
|
Benzeneacetio acid, 1-chl oro-alpha-(1-
chiorophenyl )-al pha-hydroxy-,ethyl ester
510156
iBat-orl: 700(D)
1
lLOW 100
I
1
Solid
100
1
ICARC
1
I
1,2-Benzenedicarboxylic add, [bis(2-
ethylhexyl)] ester
117817
lRat-orls31 mg/kg(D)
1
ILCU 100
1
1
F 120
100
1
ICARC
1
|
Note 10
Benzidine
92875
10-1 (B)
iRat-orl: 309(D)
1
Iked 10
ICT=28(B)
1
Solid
10
1
ICARC
1
1,2-Benzlsothiaz0lin-3-one, 1,1-dioxide,
and salts
81072
1
lLOW 100
1
Solid
100
1
ICARC
1
Benzo[a]anthracene
56553
1
Iked 10
|CT=I.D.
1
Solid
10
1
ICARC
1
|
Benzo[blfluoranthene
205992
1
IKIGH 1
ICTsI.D.
I
1
1
ICARC
1
Benzo (k)fluoranthene
207089
1
ICARCrC
1
10
1
ICARC
I
Note 15
Benzo[a]pyrene
50328
1
IHIGH 1
ICTs16(A)
1
Solid
1
1
ICARC
1
I
3, 1-Benzopyrene
50328
1
IttLffl 1
|CT=16(A)
1
Solid
1
1
ICARC
1
I
Benzotri chloride
98077
iRat-lhl: 125/1H(C)
1
Iked 10
i
F 260
10
1
ICARC
1
1,2-Benzphenanthrene
218019
1
lLOW 100
|CT=I.D.
1
Solid
100
1
ICARC
1
1
Benzyl chloride
100117
10-1 (B)
IRat-orl: 1231(D)
IRat-lhl: 150/21(0
1
ICARC=c
1
1
1
1
1
F 153(Max)
B 351
Requires
Stabilizer
(B)
100
10
1
ICARC
1
1
1
1
1
Notes 15
16
Berylllun jf
7110117
10-100(C)
1
IKED 10
|CT=I.D.
1
Solid
10
1
ICARC
1
1
Berylliun chloride
7787175
100-10 (C)
IRat-orl: 86(C)
1
IMED 10
|CT=16.7(A)
1
R:NH3 (d)
5000
10
1
jCARC.CTX
1
Note 17
Beryllium dust tt
7110117
10-100(C)
1
IMED 10
|CT=I.D.
I
Solid
10
1
ICARC
1
1
RQTBL/CARC0185A.DTB/CONDATA.HED/12-APR-85 12:16:01
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
1 1
| | Aquatic
1 1 Toxicity
1 CASRN I (Note 2)
1
1
1
1 Mansnalian Toxicity (Note 3)
I Chronic
j Toxicity/
ICarcinogen
1 (Note 4)
gnitabllity/
Reactivity
(Note 5)
311
RQ
Note 6)
Proposed
RQ
(Note 7)
Basis for
Proposed RQ
(Note 8)
Ccmments
Beryllium fluoride
1 1
1 7787497I500-100(D)
I I
1 1
1
IRat-orl: 98(C)
1
|
1
IMED 10
|CT=49.6(A)
|
Solid
5000
10
CARC.CTX
Beryllium nitrate
1 1
|13597994I500-100(D)
1 1
1 1
1
1
1
1
I
IMED 10
|CT=44(A)
I
Solid
5000
10
CARC.CTX
alpha - BHC
1 3198461
I I
1
IRat-orl:177(D)
I
I
IHIGH 1
t
1
CARC
Note 18
beta - BHC
1 1
1 3198571
| I
1
iRat-orls6000(D)
I
I
ILOW 100
1
1
CS
Note 18
ganma - BHC
1 1
1 58899l<0.1
I I
| |
(X)
1
lRat-orl:76(C)
iRat-skn: 500(D)
I
I
ILOW 100
I
1
Solid
1
1
311
Note 10
2,2'-Bioxirane
1 1
1 14645351
1 1
I |
1
IRat-orl: 78(C)
|Rat-ihl:90/4H(C)
I
I
ILOW 100
I
1
100
CARC
(1,1'-Biphenyl)-4,4 'diamine
1 1
1 92875110-1
1 1
1 1
(B)
1
IRat-orl:309(D)
I
I
1
IMED 10
iCT=28(B)
i
Solid
10
CARC
(1,1'-Blphenyl)-
M,M'di amine,3»3'dichloro-
1 1
1 919411
1 1
1 1
1
1 Rat-orl:LDlo:4740 ms/kgtD)
1
I
I LOW 100
|CT=I .D.
1
Solid
10
CARC
Notes 10
25
(1,T-Biphenyl)-
4,4' di amine,3>3'dimethoxy-
1 1
1 1199041
1 1
1 1
1
IRat-orl: 1920(D)
I
1
1
(LOW 100
I
1
Solid
100
CARC
(1, 1'Biphenyl)-4,4'-di amine, 3,3'-
dimethyl-
1 1
1 1199371
1 1
1 1
I
1 Rat-orl CD)
1
1
1
IMED 10
I
1
Solid
10
CARC
Bi3 (2-chloroethyl) ether
1 11144411000-100(D)iRat-orl:75(C)
I I iRat-ihl:1000/45M
1 1 1
1
IMED 10
I
1
F131(D)
10
CARC
Bls(chloranethyl) ether
1 1
1 5428811-
1 1
1 1
1
IRat-orl:210(D)
lRat-ihl:7/7H(B)
1
1
IHIGH 1
1CT=I .D.
1
10
BHP
Note 19
Bis (2-ethylhexyl) phthalate
1 1
1 1178171
1 1
1
|Rat-orl:31 mg/kg(D)
1
I
IL0W 100
1
F 420
100
CARC
Note 10
1,3-Butadiene, 1,1,2,3,4,4-hexachloro-
1 1
1 87683l<0.1
I I
1 |
(X)
1
1 Rat-orl: 90(C)
1
1
l
|L0W 100
1CT=10.3(C)
1
1
AQTX
Note 10
1-Butanamine, N-butyl-N-nitroso-
1 1
1 9241631
1
IRat-orl:1200(D)
I
1
IMED 10
¦
10
CARC
Butanoio acid, 4-[bis(2-chloroethyl)
amino]benzene-
1 |
1 3050331
1 1
1 1
1
1
1
I
\
lCARC=c
1
1
Solid
10
CARC
Note 15
Cacodylic acid
I I
1 756051
1 1
1
IRat-orl:700(D)
1
1
IHIGH 1
¦
Solid
1
CARC
Note 20
Cadniuni tt
1 1
1 74404391
1 1
1 1
1
IRat-orl: 225(D)
1
1
1
IMED 10
ICT=I.D.
I
Solid
10
CARC
Note 10
RQTBL/CARC0485A.DTB/CONDATA.HED/12-APR-85 12:16:04
-------
cm FDR THE HPHH HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1}
1
1
1
1 CASRN
Aquatic
Toxicity
(Mote 2)
1 Manual ian Toxicity (Note 3)
I Chronic
1 Toxicity/
(Carcinogen
1 (Note l|)
Ignitahility/
Reactivity
(Hote 5)
311
HQ
Note 6)
1
Proposed| Basis for
RQ IProposed RQ
(Note 7)1 (Note 8)
Canments
Ca(fed«n acetate
1
1 5M3908
\
l
10-1 (B>
1
IMED 10
ICTsMI(A)
)
IKED 10
|CT=^1(A)
1
Solid
100
10
1
ICARC,CTX
1
I
Note
10
Cadmium bromide
1
1 7789*126
1
i
10-1 (B)
Solid
100
10
1
1CARC,CTX
1
i
Note
10
Cadmiun chloride
1
1101086»12
1
|
1.94
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hasardous Substance (Note 1)
1
1
1
1 CASRN
Aquatic
Toxicity
(Note 2)
Mammalian Toxicity (Note 3)
1 Chronic I
1 Toxicity/|Ignitability/
ICarcinogenl Reactivity
1 (Note 1)1 (Note 5)
311
RQ
Note 6)
Proposed
RQ
(Note 7)
Basis for
Proposed RQ
(Note 8)
Comments
Chlornaphazine
1
1 1491031
I
1
ICARC=c
1
I
ISolid
|
10
CARC
Note
15
1-Chloro-2,3-epoxypropane
1
1 106898
1
1
1
100-10 (C)
Rat-orls90(C)
Rat-ihl:LClo:250 ppm/lH(C)
Rat-sl
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
1 1
I | Aquatic
I I Toxicity
1 CASRN 1 (Note 2)
1
1
1
I Mammalian Toxicity (Note 3)
I Chronic
I Toxicity/
I Carcinogen
I (Note 1)
Ignltability/
leactivlty
(Note 5)
311
RQ
Note 6)
I
Proposed I Baals for
RQ IProposed RQ
(Note 7)I (Note 8)
Comments
l.t'-DDD
1 1
1 72518 K0.1 (X)
1 1
I |
1
iRat-orl: 113(D)
IRbt-skn:1200(D)
1
I
I LOW 100
I
1
Solid
1
1
I
1311
I
|
Note 10
DDE
1 1
1 725591<0.1 (X)
I |(1 datun)
i i
1
iRat-orliBBO(D)
|Mus-orl: 200(D)
i
1
IL0W 100
1
1
1
1
IAQTX
1
|
Note 10
H,t'-DDE
1 1
1 72559 K0.1 (X)
I 1(1 datun)
i i
1
IRat-orl: 880(D)
iMus-orl: 200(D)
i
1
IL0W 100
I
1
1
IAQTX
1
|
Note 10
DDT
1 1
1 50293K0.1 (X)
I I
I I
I I
I I
i |
1
IRat-orl: 113(D)
iRat-skn: 1931(D)
IMus-orl: 135(D)
|Kky-orl: 200(D)
iRbt-orl: 250(D)
1
1
IL0W 100
1
1
1
1
|
Solid
1
1
1311
I
I
I
I
j
Note 10
1,1'-DDT
1
1 50293I<0.1 (X)
I I
I I
I I
I I
1 i
i
IRat-orl:113(D)
IRat-skn: 1931(D)
IMus-orl: 135(D)
iKky-orl: 200(D)
IRbt-orl: 250(D)
i
1
IL0W 100
1
1
1
1
|
Solid
1
1
1311
1
1
1
1
1
Note 10
Decachlorooctahydro-1,3, t-inetheno-21-
cyclobuta-[c,d]-pentalen-2-one
1 1
1 143500K0.1 (X)
I I
I I
i i
i
IRat-orl: 95(C)
IRbt-orl: 65(C)
IRbt-skn: 3<45(D)
1
1
IMED 10
1
1
|
Solid
1
1
1311
1
1
1
Note 10
Diallate
1 I
1 230316UI
l i
1
IRat-orl: 395(D)
j
1
IL0W 100
1
Solid
100
V
ICARC
1
Diamine
I I
1 3020121
I i
1
iMus-lhl:252/UH (C)
1
1
IHIGH 1
1
Spont.lgn.(A
1
1
ICARC
j
2, li-Dlaminotoluene
1 1
1 958071
i i
1
IRat-orl: 260(D)
I
1
(LOW 100
1
Solid
100
ICARC
1
Dibenz[a,h]anthracene
i 1
1 537031
1 1
i i
1
1
1
I
1
IHICM 1
|CT=X.D.
1
Solid
1
1
ICARC
1
1
1,2:5,6-Dibenzanthracene
1 1
1 537031
1 1
1 I
I
1
1
I
1
iHica-j 1
|CT=I -D.
1
Solid
1
1
ICARC
1
|
Dibenzo[a,h]anthracene
1 1
1 537031
1 1
1 1
1
1
1
I
l
IHXGH 1
|CT=X.D.
I
Solid
1
1
ICARC
1
|
1,2:7,8-Dibenzopyrene
J 1
1 1895591
i i
1
1
I
1
|CARC=C
I
Solid
10
1
ICARC
j
Note 15
Dlbenz[a,1]pyrene
i i
1 1895591
1 |
1
1
1
1
|CARC=c
1
Solid
10
ICARC
|
Note 15
1,2-Dibromo- 3-chloropropane
1 961281
1 1
1 1
1
IRat-orl: 170(D)
iRat-lhl: 103/8H(C)
I
1
IHIGH 1
I
I
1
ICARC
1
1
RQTBL/CARC0U85A .DTB/CONDATA.HED/12-APR-85 12:16:01
-------
DATA FOR THE NPHM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1}
1 1
1 I Aquatic
1 1 Toxicity
I CASRN 1 (Note 2)
Mammalian Toxicity (Note 3)
I Chronic
I Toxicity/
I Carol no gen
I (Note 4)
Ignitability/
Reactivity
(Note 5)
311
no
Note 6)
Proposed
RQ
(Note 7)
Basis Tor
Proposed RQ
(Note 8)
Comments
S-(2,3-Dichloroallyl)
diisopropylthiocarbamate
1 1
1 23031641
1 1
I |
Bat-orl: 395(D)
I
I LOW 100
1
I
Solid
100
CARC
Dlchlorodiphenyl dlchloroethane
1 1
1 725181 <0.1 (X)
I t
I |
Rat-orl: 113(D)
Rbt-skn:1200(D)
1
lLOW 100
1
I
Solid
1
1
311
Note 10
3,3'-Dichloro benzidine
1 1
I 919111
I l
i i
Bat-orl:LDlo:4740 mg/kg(D)
1
lLOW 100
ICT=I.D.
1
Solid
10
CARC
Notes 10
25
Dlchlorodiphenyl trichloroethane
1 I
1 502931 <0.1 (X)
1 1
1 1
t 1
1 1
1 |
Bat-orl:113(D)
Rat-skn:1931(D)
Mus-orl:135(D)
Mky-orl:200(D)
Rbt-orl:250(D)
1
lLOW 100
I
I
I
I
I
Solid
1
1
311
Note 10
1,2-Dichloroethane
1 1
1 10706211000-100
I I (D)
I I
| 1
Rat-orl:670(D)
Rat-lhl LClo: 1000 ppm/4H(D)
Mus-orl 1600 LDlo(D)
1
ILOW 100
tCT=l8.4(C)
1
I
P 56(C)
B 183
5000
100
CARC
1,1-Dlchloroethylene
1 1
1 7535111000-100
1 1(D)
1 1
| |
Rat-orl:200(D)
Rat-lhl:10,000/2lH(D)
Mu3-ihl:LC50:98 ppm/22H(C)
\
lLOW 100
ICT=19(C)
1
i
F 0(B)
B 99
5000
100
CARC.I
Note 26
Dichloroethyl ether
1 111444I1000-100(D)
I I
Bat-orl:75(C)
Rat-lhl:1000/45M
[
IMED 10
1
I
F131(D)
10
CARC
Dichloropheny1arsine
I |
I 6962861
1 1
1 )
1 |
Rat-skn: 16(C)
Rbt~skn:0.5(B)
Gpg-3kn:4(B)
1
IHIGH 1
ICTzI.D.
I
I
1
CARC
Note 20
Dieldrin
1 1
1 60571 U0.1 (X)
1 1 "
Rat-orl:46(C)
l
IHIGH 1
Solid
1
1
311.CARC
Dote 10
1,2:3,4-Diepoxy butane
\ 1*46*45351
1 1
I |
Rat-orl:78(C)
Rat-lhl:90/4H(C)
1
lLOW 100
1
I
100
CARC
Diethylarsine
1 692M22I
1 1
I i
1
iHicm 1
ICT=I.D.
1
ILOW 100
I
Pyro (A)
1
CARC
Notes 20
27
1i4-Dlethylene dioxide
1 1
1 1239H |100-1000{D
I |
Rat-orl:4200(D)
F54,B214(C)
100
CARC
N ,N'-Diethyl hydrazine
I i
1 16156011
i |
1
ICARCrC
I
10
CARC
Note 15
Dlethylstilbestrol
i i
1 565311
1 |
Mus-orl:2500(D)
l
IHIGH 1
i
Solid
1
CARC
Dihydrosafrole
1 945361
i i
Rat-orl:2260(D)
1
lLOW 100
¦
100
CARC
3,3'-Dimethoxy benzidine
i i
1 1199011
1 1
Rat-orl:1920(D)
1
lLOW 100
I
Solid
100
CARC
RQTBL/CARC0485A.DTB/CONDATA.HED/12-APK-85 12:16;04
-------
DATA FOR THE NPBM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
1 1
| | Aquatic
j | Toxicity
I CASRN I (Note 2)
Mammalian Toxicity (Note 3)
1 Chronic
1 Toxicity/
1 Carcinogen
1 (Note 1)
gnitability/
Reactivity
(Note 5)
311
RQ
Note 6)
Proposed
RQ
(Note 7)
Basis for
Proposed RQ
(Note 8)
Ccmnents
Dimethyl ami noazo benzene
1 I
1 601171
| |
Rat-orl: 200(D)
1
IHIGH 1
Solid
1
CARC
7,12-Dimethylbenz[a]anthracene
1 579761
1 |
Rat-orl:327(D)
1
Ihigh 1
1
Solid
1
CARC
3,3*-Dimethylbenzldine
1 1199371
1 |
Rat-orl:101(D)
1
Iked 10
i
Solid
10
CARC
Dimethyl carbamoyl chloride
1 1
1 791471
1 |
Rat-orls1000
1
Ihigh 1
¦
1
CARC
1,1-Dlmethyl hydrazine
1 571*471
I |
Rat-lhls 252/1H(C)
i
Iked 10
¦
Spont.ign.(A)
10
I,CARC
1,2-Dimethyl hydrazine
1 5107381
1 1
| |
Rat-orl: 100(C)
rat ihl 280/1H(C)
i
Ihigh 1
I
i
1
CARC
Dlmethylni trosamine
1 627591
1 1
1 i
Rat-orl:26(C)
Rat-lhl:LC50:78/1H(C)
i
Iked 10
I
¦
10
CARC
Dimethyl sulfate
i i
1 77781110-100(0
1 1
1 |
Rat-orl:110(D)
Rat-ihl:32/lH lo(B)
i
ICARC=c
1
1
F182
100
BHP
Note 15
Dlnitrotoluene
i i
12532111)61100-10 (C)
I 1
1 i
1
IL0W 100
|CT=29.7(B)
l
Solid
1000
100
CARC.CTX
Note 28
3,4-Dinltrotoluene
1 1
1 6103991100-10 (C)
1 1
1 |
1
ILCW 100
|CT=29.7(B)
I
Solid
1000
100
CARC.CTX
Note 28
2,4-Dinitrotoluene
> i
1 1211l2|10-100 (C)
1 1
1 i
Rat-orl: 268(D)
l
ILOW 100
|CT=32(B)
i
F tOl(Max)
B 576
1000
100
CTX, CARC
2,6-Dinitrotoluene
1 1
1 606202|10-100(C)
I I
I |
Rat-orl:177(D)
1
ICARC=c
ICT=30(B)
i
Solid
1000
100
CARC
Notes 15
29
1, t-Dloxane
¦ 1
1 1239111100-1000(D)
| |
Rat-orl:1200(D)
1
IL0W 100
I
F51,B211(C)
100
CARC
1,2-Diphenylhydrazlne
i i
1 12266711-0.1(A)
1 1
1 1
1 6216171
1 1
Rat-orl: 301(D)
I
IMED 10
|CT=28(B)
I
Solid
10
AQTX.CARC
Notes 10
30
Di-n-propylnitrosamine
Rat-orl:180(D)
¦
|CARC=c
¦
10
CARC
Note 15
Epichlorohydrln
1 1
1 1068981100-10 (C)
1 1
1 1
1 |
Rat-orl: 90(C)
Rat-ihl:LClo:250 ppm/lH(C)
Rat-skn:LDlo:1000(D)
1
ILCW 100
ICT=26(B)
1
i
F 91(C)
B 239
1000
100
CARC.CTX
Ethanamine, N-ethyl-N-nltroso-
1 1
1 551851
1 |
Rat-orl: 280(D)
i
IHIGH 1
i
1
CARC
Ethane, 1,2-dibrccio-
1 1
1 106931I10-100(C)
I I
I I
I I
Rat-orl: 108(D)
Rbt-orl: 55(C)
Rat-ihl:100/2UC)
1
IMED 10
I
I
I
1000
10
CARC
RQrBL/CARC0185A.DTB/00NDATA.HED/12-APR-85 12s 16:01
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
I I
1 1 Aquatic
1 t Toxicity
1 CASRN 1 (Note 2)
1
*
1
1 Mammalian Toxicity (Note 3)
1 Chronic
1 Toxicity/
1 Carcinogen
1 (Note 14)
Ignitability/
Reactivity
(Note 5)
311
RQ
iNote 6)
Proposed
RQ
(Note 7)
Basis for
Proposed RQ
(Note 8)
Comments
Ethane, 1,2-dlchloro-
1 1
1 10706211000-100
I KD)
I I
¦ |
1
IRat-orl:670(D)
IRat-lhl LClo; 1000 ppn/MH(D)
!Mus-orl:600 LDlo(D)
1
1
lLOW 100
|CT=18.4(C)
I
I
F 56(C)
B 183
5000
100
CARC
Ethane, 1,1,1,2,2,2-hexachloro-
t 67721110-KB)
1 1
i i
1
IRat-orl:6000(D)
1
i
I
I LOW 100
|CT=15.2(C)
1
Solid
100
AQTX.CARC
Ethane, 1,1'-oxybis[2-chloro-
1 1 1
1 111444| 1000-100(D) iRat-orl; 75(C)
1 1 iRat-lhl:1000/45M
i i i
1
IMED 10
I
1
F13KD)
10
CARC
E thane, 1,1,1,2-tetraohloro-
1 6302061
1 1
¦ i
1
1
1
1
|CARC=c
|CT=I.D.
I
10
CARC
Note
15
Ethane, 1,1,2,2-tetrachloro-
i i
1 793^5110-1 (B)
1 1
1 i
1
|Rat-ihl:LCLo: 1000/4H(D)
lDog-orl:LDLo:300(D)
i
1
lLOW 100
|CT=1?.5(C)
i
100
AQTX.CARC
Note
10
E thane, 1,1,2-trlchloro-
l i
1 790051100-10 (C)
1 1
i i
1
|Rat-orl:11U0(D)
|Rat-ihl:LCLo:500/8H(D)
1
l
lLOW 100
|CT=I.D.
i
100
CARC
Ethanethloamide
1 1
1 625551
¦ |
1
lRat-orl:200(D)
I
1
IKED 10
1
Solid
10
CARC
Ethanol, 2,2'-(nitro30imino)bis-
1 11165171
¦ |
I
IRat-orl:7500(D)
i
I
IMED 10
i
10
CARC
Ethenamine, N-methyl-N-nltroso-
I 45*494001
1 1
1
|Rat-orl:2iJ(C)
i
1
|CARC=C
i
10
CARC
Note
15
Ethene, chloro-
1 I
1 75011)11000 (D)
1 1
I i
l
IRat-orl;500(D)
|Gpg-ihl:LCLo: 20/3CN(B)
1
1
I LOW 100
lcr=20(c)
i
F GAS(B)
B 7
100
CARC.I,
T(lhl)
Note 36
Ethene, 1,1-dichloro-
1 f
1 7535411000-100
1 1(D)
1 1
1 t"
i
IRat-orl:200(D)
IRat-lhl:10,000/24H(D)
iMua-ihl:LC50:98 ppa/22H(C)
1
i
lLOW 100
lcr=i9(c)
I
i
F 0(B)
B 99
5000
100
CARC,I
Note
26
Ethene, 1,1,2,2-tetrachloro-
1 1
I 12716MI100-10 (C)
1 1
| |
1
|Mus-orl:8l00(D)
|Rab-ihL:LCLo;MOOO/WD)
i
i
I LOW 100
lCT=10(C)
I
100
CARC
Ethyl carbamate (Urethan)
1 517961
i i
i
iMua 2500 (D)
I
1
lLOW 100
i
Solid
100
CARC
Ethyl 4,4'-dichlorobenzilate
i i
1 5101561
1 |
1
IRat-orl: 700(D)
1
1
lLOW 100
I
Solid
100
CARC
Ethylene di bromide
i i
1 106934110-100(C)
I I
I I
I i
i
IRat-orl: 108(D)
lRbt-orl:55(C)
IRat-lhl:400/2H(C)
I
IMED 10
1
1
1000
10
CARC
Ethylene dlchloride
1 1
1 1O7062I1000-100
I I CD)
I I
¦ |
i
IRat-orl:670(D)
IRat-lhl LClo: 1000 ppn/4H(D)
iMus-orl:600 LDlo(D)
1
1
lLOW 100
|CT=18.4(C)
1
F 56(C)
B 183
5000
100
CARC
Ethylene oxide
| 1
1 75218110-100(C)
1 1
1
IRat-orl:72(C)
1
1
IMED 10
I
F<0,B51(B)
10
CARC
ROTBL/CARCOl(85A.DTB/OOHCATA.HED/12-APR-85 12:16:04
-------
DATA TOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
I
I Aquatic
I Toxicity
CASRN | (Note 2)
1
1
1
1 Haranallan Toxicity (Note 3!
1 Chronic 1
1 Toxicity/
(Carcinogen
1 (Note 1)
Suitability/
Reactivity
(Note 5)
311
RQ
Note 6)
Proposed
RQ
(Note 7)
1
1 Basis Tor
1 Proposed RQ
1 (Note 8)
C contents
Ethylenethlourea
I
961571
1
IRat-orl:1832(D)
|
1
ILOW 100
1
Solid
100
1
ICARC
|
Ethyl eni mine
1
1515641
I
I
1
iRat-orls15(C)
Iflat-ihl:25/8H lo(B)
i
1
(HIGH 1
|CT=I.D.
j
Needs
stabllizer(B)
1
ICARC
1
|
Ethyl nethanesulfonate
1
625001
1
1
1
i
|HI(M 1
I
1
ICARC
1
Formaldehyde
1
500001100-10 (C)
1
1
1
IRat-orl: 800(D)
lPat-ihl;LCLo:250 ppa/lH (C)
lPbt-akn:270 (D)
1
1
1LCM 100
|CT=39(B)
1
1
IHIGH 1
I
1
F GAS(B)
B -3
1000
100
1
|CARC,CTX,I
1
1
D-Clucopyranoae, 2-deoxy-2-(3-oethyl-3-
nitrosoureido)-
|
188836611
1
1
iKus-orl:261(D)
1
i
Solid
1
ICARC
1
|
Clyeldylaldehyde
|
7653111
1
702571
1
IRat-orl:50(C)
i
1
1MED 10
I
10
ICARC
1
Guanldine, N-nltroso-N-oethyl-N'-nltro-
i
lHat-orl: 90(C)
i
i
IKED 10
1
Solid
10
1
ICARC
|
Heptachlor
|
76118 K0.1 (X)
1
i
i
|Rat-orl:10(C)
iRat-skn: 119(D)
i
1
|HED 10
I
1
Solid
1
1
1311
I
I
Note
10
Heptachlor epoxide
i
10215731
1
i
IRat-orl:62(C)
1
I
IMED 10
I
Solid
1
ICS
I
Notes
10
3f
Hexachlorobenzene
1
1187111
1
i
1
IRat-orl:10,000(0)
I
1
I
IMED 10
|CT=29-5(B)
i
Solid
10
I
ICARC
I
|
Note
10
Hexachloro butadiene
876831<0.1 (X)
1
i
1
IRat-orl s 90(C)
1
i
1
IL0W 100
|CT=10.3(C)
1
1
IAQTX
I
[
Note
10
Hexachlorocyclohexane (gamna 1 saner)
i
58899 K0.1 (X)
1
1
1
IRat-orl!76(C)
iRat-sVn:500(D)
I
1
lLOW 100
1
|
Solid
1
1
1311
I
|
Note
10
Hexachlorocyclopentadiene
1
7717711<0.1 (X)
I
i
1
IRat-orl: 113(D)
lRbt>akn:130(D)
I
|CT=62(A)
1
1
Solid
1
1
1311
I
|
Note
10
l,2,3,1,10,lO-HexacHloro-617-epoxy-
1 f 11 15,6,7 f 6, 8a- octahydro- endo, e xo-
1,1:5,8-dlmethanonaphthalene
i
60571K0.1 (X)
1
1
t
1
IRat-orl: 16(C)
1
1
1
1
I Him 1
I
I
i
Solid
1
1
I311.CARC
1
1
1
Note
10
Hexachloroettiane
i
67721110-KB)
I
i
1
IRat-orl: 6000(D)
1
I
I
|L0W 100
|CT=15.2(C
1
Solid
100
1AQTX ,CARC
1
|
1,2,3,1,lO-IO-Hexachloro-l.l.la.S,8,8a-
hexahydro-1,4:5,S-endo,exo-
dimethanonaphthal ene
1
309002|<0.1(X)
1
1
1
IRat-orl:39 (C)
1
1
I
1
IMED 10
1
1
I
Solid
1
1
1311
1
1
I
Note
10
Hydrazine
1
3020121
1
1
|Hus-lbl:252/1H(C)
1
1
IHICH 1
1
Spont,ign.(A
1
1
ICARC
1
HOTBL/CARC0185A.DTB/COHDATA.HED/12-APR-85 12:16:01
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
I I
I I Aquatic
I I Toxicity
I CASRN I (Note 2)
1
1
1
| Mammal 1 an Toxicity
1 Chronic I
I Toxicity/11gnitability/
ICarcsinogenl Reactivity
(Note 3) 1 (Note 1)1 (Note 5)
311
RQ
(Note 6)
1
Proposed 1 Basis for
RQ I Proposed RQ
(Note 7)1 (Note 8)
Cccnments
Hydrazine, 1,2-diethyl-
I I
I 16158011
1
1
1
ICARCzC
i
1
i
10
I
ICARC
i
Note
15
Hydrazlne, 1,1-dimethyl-
1 |
1 571171
1 1
|
lRaUihl:252/4H(C)
i
i
IMED 10
1
1
iSpont.lgn.(A)
i
10
1
ll.CARC
|
Hydrazine, 1,2-dimethyl-
1 1
1 5107381
1 1
1 1
1
lRaUorl: 100(C)
Irat lhl 280/UH(C>
i
1
IHIGH 1
I
i
I
i
i
i
1
1
ICARC
1
I
Hydrazlne, 1,2-di phenyl-
1 1
1 12266711-0.1(A)
1 1
1 1
1
IRat-orl: 301(D)
I
i
1
IKED 10
|CT=28(B)
i
I
(Solid
1
i
10
i
|AQrX,CARC
1
\
Notes
10
30
Hydroxy dimethyl araine oxide
1 1
1 756051
1 |
1
iRat-orl: 700(D)
1
1
IHIGH 1
|
1
ISolid
I
1
1
ICARC
j
Note
20
2-Imida zol idi nethi one
i i
1 961571
| 1
i
iRaUorl: 1832(D)
t
i
ILOW 100
i
i
1 Solid
l
100
ICARC
1
Indeno[1,2,3-cdIpyrene
1 1
1 1933951
1 1
I
I
I
i
1
|CARC=C
|CT=I.D.
i
1
1Solid
1
¦
10
1
ICARC
1
1
Note
15
Isocyanic acid, methyl eater
| |
1 6218391
1 1
| I
I
|Rat-orl:7l(C)
|Rat-IhI:5/MH(B)
i
1
1
1
i
1
|F19,B102(C)
I
i
1
\
ISTAT
1
i
Note
32
Isosafrole
1 1
1 1205811
1 1
I
IRat-orl: 13*»0(D)
i
1
lLOW 100
i
1
1
¦
100
1
ICARC
Kepone
1 1
1 113500K0.1
I I
I I
(X)
1
Iflat-orl: 95(C)
|Rbt-orl;65(C)
iRbt-skns345(D)
i
I
IMED 10
1
1
i
l
1Solid
1
1
|
1
1
1311
I
I
Note
10
Lasiooarpine
| |
I 3033HI
1 1
t
IRat-orl:150(D)
i
1
IMED 10
i
1
t Solid
1
10
J
tCARC
|
Lead acetate
1 1
1 3010121500-100(D)
1 1
t |
1
iDog-orl sLXos 300(D)
iDog-orl:300(D)
l
1
ILOW 100
ICT=32(B)
i
1
1 Solid
1
I
5000
100
1
ICARC ,CTX
1
I
Note
to
Lead arsenate
l l
1 77811091500-100(D)
1 1
i i
I
IRat-orl: 100(C)
|Rbt-crl:75(C)
i
1
IHIGH 1
|CT=13(C)
I
l
)
1
I
5000
1
1
ICARC
1
i
Note
10
Lead phosphate
i i
1 71162771
1 1
i i
1
1
1
¦
\
|CARC=C
|CT=33(B)
l
1
1Solid
1
t
10
l
ICARC
1
1
Note
15
Lead subacetate
i i
1 13353261
1 1
¦ *
i
1
1
¦
i
lLOW 100
ICT=33(B)
i
t
1
1
¦
100
l
ICARC ,CTX
1
1
Lindane
i i
I 58899K0.1
I I
¦ i
(X)
I
IRat-orl: 76(C)
IRat-slci: 500(D)
I
1
I LOW 100
1
l
1
1Sol id
1
¦
1
1
1311
I
1
Note
10
Lithim chromate
i i
1113073581100-10 (C)
I I
¦ i
1
1
1
i
1
IMED 10
ICTsI.D.
1
1Sol id
1
I
1000
10
I
ICARC
I
¦
Note
10
Melphalan
i i
1 1188231
1 1
1
1
1
I
IHIGH 1
1
1
1Solid
1
1
i
ICARC
I
RQTBL/CARC01B5A .OTB/CONDATA .HED/12-APR-85 12:16:01
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
I
I Aquatic
I Toxicity
CASRN I (Note 2)
1
1
1
1 Mammalian Toxicity (Note 31
1 Chronic
1 Toxicity/
ICarcinogen
1 (Note 4)
I gnitabillty/
Reactivity
(Note 5)
311
RQ
Note 6)
Proposed
RQ
(Note 7)
1
1 Basis for
1 Proposed RQ
1 (Note 8)
Coranents
Methane, ohloromethoxy-
I I
1073021100-1000(D)|Rat-orl:8l7(D)
1 lRat-ihl:55/7H(C)
i i
1
IHIGH 1
|CT=30.4(B)
I
10
1
IBHP
1
1
Note
19
Methane, lodo-
748841
1
iRat-orl: 150(D)
I
1
ICARC=c
i
10
1
ICARC
i
Note
15
Methane, oxybis(chloro-
1
5428811
1
i
1
|Rat-orl: 210(D)
|Rat-ihl:7/7H(B)
1
1
IHIGH 1
|CT=I.D.
1
10
1
IBHP
1
i
Note
19
Methane, tetrachloro-
1
56235l100-10(C)
1
1
1
IRat-orl; 2800(D)
IRat-ihl:1000/MH
1
1
IMED 10
ICT=25.3(B)
1
5000
10
1
ICARC
1
1
Methane, trlchloro-
1
67663l100-10(C)
I
i
1
IRat-orls800(D)
IRat-ihl: 8000/MH(D)
1
(LOW 100
I
1
5000
100
l
ICARC
1
1
Methanesulfonic add, ethyl ester
I
625001
1
1
1
Irigh 1
1
1
1
ICARC
i
4,7-Methano-1H-indene,1,4,5,6,7,8,8-
heptachloro- 3a,1,7,7a-tetrahydro-
1
76448 K0.1 (X)
1
1
I
IRat-orl: M0(C)
iRat-akri: 119(D)
1
1
IMED 10
1
i
Solid
1
1
1311
I
l
Note
10
4,7-Methanolndan, 1,2,4,5,6,7,8,8-
octachloro-3a,t,7,7a-tetrahydro-
i
57719 K0.1 (X)
I
1
1
iRat-skns 700(D)
iRbt-orl: 100(C)
l
i
lLOtf 100
1
1
Solid
1
1
1311
I
I
Note
10
2-Methyl azl ridine
1
755581
i
I
IRat-orl: 19(C)
1
1
IMED 10
I
10
i
ICARC
1
ICARC
1
1,1'-Methylenebis(2-chloroaniline)
I
101141)1
1
1
1
1
(LOW 100
i
Solid
100
3-Methylcholanthrene
1
564951
i
1
1
1
1
IMED 10
I
Solid
10
l
ICARC
1
Methylene oxide
I
500001100-10 (C)
1
1
1
1
IRat-orl:800(D)
lRat-ihl;LCLo:250 ppn/»M (C)
|Rbt-3kn: 270 (D)
i
I
ILOW 100
1CT=39(B)
1
F GAS(B)
B -3
1000
100
l
|CARC,CTX,I
1
1
I
Methyl iodide
1
7U88it|
1
1
IRat-orl: 150(D)
i
1
|CARC=c
i
10
1
ICARC
I
Note
15
Methyl isocyanate
1
6248391
1
i
I
|Rat-orl:71(C)
lRat-ihl:5AH(B)
i
1
1
1
F19,B102(C)
1
1
ISTAT
1
I
Note
32
N-Methyl-N'-nitro-N-nitrosoguanidine
I
702571
I
1
IRat-orl:90(C)
i
1
IMED 10
I
Solid
10
1
ICARC
I
Methylthiouracll
i
560121
|
i
iRbt 2500 (D)
i
I
IMED 10
1
Solid
10
i
ICARC
I
Mitomycin C
500771
i
1
IRat-orl:14(C)
i
1
lCARC=C
1
Solid
10
1
ICARC
1
Note
15
5,12-Naphthacenedlone, (fis-cls)-8-
acetyl-10-[3-amino-2,3,6-trideoxy-alpha-
L-lyxo-hexapyranoxyl)oxyl-7,8,9,10-
tetrahydro-6,8,11-trihydroxy-1-methoxy-
1
208308131
1
1
1
1
1
1
1
1
1
1
1
ICARCrC
1
1
1
1
Solid
10
l
ICARC
1
1
I
1
Note
15
RQTBL/CARC0485A.DTB/0ONDATA.HED/12-APR-85 12:16:0H
-------
DATA FOR ITO NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1}
I
I Aquatic
I Toxicity
CASRN I (Note 2)
Manmalian Toxicity (Note 3)
I Chronic
1 Toxicity/
1Carcinogen
1 (Note 1)
Igriitabllity/
Reactivity
(Note 5)
311
RQ
(Note 6)
1
Proposed1 Basis for
RQ I Proposed RQ
(Note 7)1 (Note 8)
Comments
2,7-Naphthalenedisulfonic acid,3,3'-
[ < 3,3'-dimethyl-{l, 1 '-biphenyl )-M, 1}'-
diyl)-bis(azo)]t)ls(5-amlno-1-hydroxy)-
tetrasodim salt
I
725711
1
1
1
1
1
lLOW 100
1
1
1
Solid
100
1
ICARC
1
t
1
1
1-Naphthylamine
1
13132711-10(B)
1
Rat-orl:779(D)
1
ICARC=c
1
Solid
10
1
ICARC
|
Note 15
2-Naphthylamine
1
91598|1-10(B)
1
Rat-orl:727(D)
1
IMED 10
1
Solid
100
1
IBHP
Note 19
alpha-Naphthylamine
i
13132711-10(B)
Rat-orl:779(D)
1
|CARC=c
1
Solid
10
ICARC
1
Note 15
beta-Naphthylamine
|
9159811-10(B)
1
Rat-orl:727(D)
1
IMED 10
1
Solid
100
1
IBHP
1
Note 19
2-Naphthylamlne, N,N-bis(2-chloroethyl)-
1
1910311
1
1
ICARC=c
1
Solid
10
1
ICARC
1
Note 15
Nickel ft
1
71100201
1
1
Gpg-orl:LDlo:5(B)
1
IMED 10
|CT=26(B)
1
Solid
10
1
ICARC
1
1
Nickel ammoniun sulfate
1
15699180I500-100(D)
I
1
1
IMED 10
|CT=35(B)
1
Solid
5000
10
1
ICARC
1
1
Nickel carbonyl
1
13163393110-100(C)
I
¦
Rat-lhl:35/3CM lo(B)
1
IMED 10
1CT=£I9CA)
1
F-1, B110(C)
10
1
ICARC,CTX
1
1
Nickel chloride
t
77185191500-100(D)
1
1
Rat-orl;105(D)
1
IMED 10
|CT=10(B)
1
Solid
5000
10
1
ICARC
1
1
Nickel cyanide
1
5571971[0.1—1(A)]
1
1
1
IMED 10
|CT=19(A)
I
I
Solid
[10]
10
1
IAOTX,
icrx,
ICARC
Note 33
Nickel(II) cyanide
I
5571971[0.1-1(A)]
I
I
I
1
IMED 10
|CT=19(A)
1
1
Solid
[10]
10
|
lAQTX,
ICTX,
ICARC
1
Note 33
Nickel hydroxide
1
120511871100-10 (C)
1
1
1
IMED 10
|CT=50(A)
1
Solid
1000
10
1
ICARC,CTX
1
1
Nickel nitrate
1
11216752150CMOO(D)
1
1
1
IMED 10
ICT=38(B)
I
Solid
5000
10
1
ICARC
1
1
RQTBL/CARC0185A .DTB/CONDATA -HED/12-APR-85 12:16:01
-------
Dm FOB THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
I
| Aquatic
I Toxicity
CASRN | (Note 2)
Manmallan Toxicity (Note 3)
I rhmnic |
I TO)dcir""I^^uiilty/
(Carcinogen| Reactivity
I (Note
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
I
I Aquatic
I Toxicity
CASRN I (Note 2)
Mammalian Toxicity (Note 3)
I Chronic
I Toxicity/
ICarcinogen
1 (Note 4)
Ignitabillty/
Reactivity
(Note 5)
311
RQ
Note 6)
I
Proposed I Basis for
RQ IProposed RQ
(Note 7)1 (Note 8)
Garments
Pentachloronltrobenzene
I
826881
1
I
Rat-orl:1650(D)
1
lLOW 100
ICT=10.4(C)
1
Solid
100
I
ICARC
I
I
Pentachlorophenol
1
8786510.2-0.6(A)
1
1
Rat—orl: 50(C)
Rat-ihl:11.7(B)
Rat-skn: 105(D)
1
|CT=20(C)
1
1
i
Solid
10
10
1311
I
I
1
Note
10
Phenacetin
|
621(1)21
1
Rat-orl: 1650(D)
I
lLOW 100
I
Solid
100
1
ICARC
1
Phenol, pentachloro-
¦
8786510.2-0.6(A)
1
1
i
Rat-orl:50(C)
Rat-ihl:11.7(B)
Rat-skn:105(D)
1
|CT=20(C)
1
1
i
Solid
10
10
1
1311
1
1
i
Note
10
phenol, 2,4,5-trichloro-
1
95954I0.1-1(A)
I
Rat-orl:820(D)
l
ICT=13(C)
I
Solid
10
10
i
1311
i
Phenol, 2,4,6-trichloro-
i
8806211.0-1 (A)
I
|
Rat-orl:820(D)
I
lLOW 100
|CT=I.D.
1
Solid
10
10
1311
1
1
Phenyl dichloroarsine
6962861
1
1
¦
Rat-skn:16(C)
Rbt-skn:0.5(B)
Gpg-skn: 4(B)
i
IHIGH 1
|CT=I.D.
1
I
1
i
ICARC
1
1
i
Note
20
1,10-(1,2-PhenyleneJpyrene
t
1933951
1
¦
1
|CARC=c
|CT=I.D.
1
Solid
10
1
ICARC
1
i
Note
15
Phosphoric acid, lead 3alt
I
74462771
1
i
l
|CAHC=C
lcr=33(B)
1
Solid
10
1
ICARC
1
I
Note
15
Phosphorothioc acid, 0,0-diethyl 0-(p-
nltrophenyl) ester
1
5638210.4(A)
1
1 .
Rat-orl:2(B)
Rat-ihl:10/2H lo(B)
Rat-skn: 6.8(C)
I
ICT=32(B)
1
1
|
1
10
1
lAQTX
1
1
1
Note
46
Polychlorlnated blphenyls (PCBs)
|
1336363K0.1 (X)
1
1
Iked 10
¦
10
1
1
lAQTX
I
Note
10
Potasslun arsenate
1
77844101100-10 (C)
1
i
i
IHIGH 1
|CT=16(C)
I
Solid
1000
1
1
ICARC
1
1
Potasslun arsenite
i
101245021100-10 (C)
I
I
Rat-orl:14(C)
Rat-skn: 150(C)
1
IHIGH 1
|CT:41(A)
I
Solid
1000
1
1
ICARC
1
1
Note
10
Potasslun bichromate
l
77785091100-10 (C)
I
i
Dog-orl:LDlo:2829(D)
l
IMED 10
|CT=I.D.
i
Solid
1000
10
1
ICARC
1
Note
10
Potassium chrcmate
i
77890061100-10 (C)
1
|
1
IMED 10
ICT=I.D.
i
Solid
1000
10
1
ICARC
1
1
Note
10
1-Propanal, 2,3-epoxy-
7653441
1
Rat-orl: 50(C)
1
IMED 10
I
10
1
ICARC
1
RQTBL/CARC0485A .DTB/OONDATA .HED/12-APR-85 12:16:04
-------
PATH FOR THE rfPRM HAZARDOUS SUBSTANCES . Continue^
Hazardous Substance (Note 1)
1
| Aquatic
I Toxicity
CASRN 1 (Note 2)
Mammalian Toxicity (Note 3)
I Chronic
j Toxicity/
ICarcinogen
I (Note 1)
JgnitabUlty/
Reactivity
(Note 5)
1 1
311 | Proposed| Basis for
RQ | RQ |Proposed RQ
(Note 6)| (Note 7)1 (Note 8)
Convents
Ppopnnc | 1 w—
1
J ts 1 LU |
1
1
•Et-ori.. "70(D)
Rat-lhl: 103/8H(C)
1
IHIGH 1
1
1
1 1
I
i
ICARC
1
1
Propane, 2-nltro-
1
791691
1
1
Rat-orlj500(D)
Rat-lhl :100/6H(C)
1
lLOW 100
1
|
F75,B218(C)
i
1 100
I
1
1
ICARC
1
|
1,3-Propane sultone
1
11207111
i
Mus-skn:1000
1
IMED 10
1
Solid
1 10
1
ICARC
|
1-Propanol, 2,3-dibrano-, phosphate
1
1267271
1
Rat-orl:1010(D)
1
IU)W 100
1
1 100
1
ICARC
1
2-Propenenitri1e
i
107131110- KB)
I
Rat-orl:82(C)
Rat-lhl:500/lH(D)
1
IL0H 100
lcr=30(B)
1
F 32(C)
B 171
1
100 I 100
I
1
1
I311.CARC,
ICTX
1
Note 9
1,2-Propylenimine
|
75558I
i
Rat-orl:19(C)
1
IMED 10
1
1 10
1
1
ICARC
i
Pyridine, hexahydro-N-nltroao-
1
1007511
1
Rat-orl:2C0(D)
1
IHIGH 1
1
Solid
1
1 1
I
1
ICARC
j
1(1H)-Pyrimidinone, 2,3-dihydro-6-
methyl-2-thioxo-
i
560121
1
i
Rbt 2500 (D)
i
IMED 10
1
1
Solid
I 10
1
1
ICARC
1
|
Pyrrole, tetrahydro-N-nitroao-
i
9305521
i
Rat-orl:900(D)
i
iHIffl 1
1
Solid
1 1
1
ICARC
1
RADIONUCLIDES
1
N.A.I
i
1
1
1
I
1 1
1
I
ISTAT
1
Note 31
Saccharin and salts
1
810721
j
1
|L0W 100
i
Solid
1
1 100
1
1
ICARC
1
Safrole
I
915971
i
Rat-orl:1950(D)
I
lLOW 100
1
F212
1
1 100
1
i
ICARC
1
Seleniun disulfide
1
71885611
1
i
Rat-orl:138(D)
1
lLOW 100
ICTsI.D.
1
R:H2S(B)
1 100
1
1
I
ICARC, R
1
1
L-Serine, diazoacetate (ester)
1
1150261
i
Rat-orl:170(D)
l
iCARC-c
i
Solid
1 10
1
1
ICARC
i
Note 15
Sodiun arsenate
1
76318921100-10 (C)
1
¦
Rbt-orl:LCLo: 12.5(C)
1
IHIGH 1
|CT=16(C)
1
Solid
1
1000 1 1
I
1
i
ICARC
1
|
Note 10
Sodiin arsenite
I
77811651100-10 (C)
1
i
Rat-orl: 11(C)
Rat-skn:150(D)
1
IHIGH 1
ICT=U1(A)
1
Solid
1
1000 I 1
1
1
i
ICARC
1
1
Note 10
Sodiun bichromate
1
105880191100-10 (C)
1
i
Rat-orl: 50(C)
1
IMED 10
|CT=I.D.
1
Solid
1
1000 1 10
1
1
¦
ICARC
1
I
Note 10
Sodiun chromate
1
77751131100-10 (C)
I
i
1
IMED 10
ICTsI.D.
i
Solid
1
1000 1 10
I
1
l
ICARC
1
1
Note 10
1,1'-Stilbenediol, alpha, alpha '-di ethyl -
1
565311
1
1
Mus-orl:2500(D)
l
IHIGH 1
I
I
Solid
1
1 1
1
1
1
ICARC
1
1
RQTBL/CARC0185A.DTB/CONDATA.HED/12-APR-85 12:16:04
-------
DATA FOR THE HPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
1 1
1 1 Aquatic
1 1 Toxicity
1 CASRN I (Note 2)
I
I
1
I Mammalian Toxicity (Note 3)
1 Chronic
1 Toxicity/
ICarcinogen
1 (Note U)
Ignitabillty/
Reactivity
(Note 5)
311
RQ
Note 6)
Proposed
RQ
(Note 7)
Basis for
Prop33ed RQ
(Note 8)
Canments
Streptozotocin
1 1
|1888366U|
I
1
lMu3-orl: 264(D)
1
IHIGH 1
1
Solid
1
CARC
Strontium ehromate
1
1 77690621100-10 (C)
1
1
1
I
1
IMED 10
1
Solid
1000
10
CARC
Note
10
Sulfur selenlde
1
1 748856U1
1 1
I
1
iRat-orl:138(D)
I
1
1
IL0W 100
|CT=I.D.
1
R:H2S(B)
100
CARC.R
Sulfuric add, dimethyl ester
1
1 77781|10-100(C)
I I
•
1
IRat-orl:440(D)
IRat-ihl:32/4H lo(B)
1
1
ICARCrc
1
1
F182
100
BHP
Note
15
TDE
I
I 72548 K0.1 (X)
1 1
i 1
1
IRat-orl:113(D)
iRbt-skn:1200(D)
1
1
ILOU 100
I
1
Solid
1
1
311
Note
10
2,3 > 7,8-T et rachl orodi benzo- p- di oxi n
(TCDD)
1 1
1 1746016K0.1 (X)
1 1
1 1
I I
1
IMus-orl:0.114(A)
|Mus-skn:LXo:0.0B(A)
IDog-orl:LILo: 3(B)
I
1
IHIGH 1
1
1
1
1
AQTX.CARC
Note
10
1,1,1,2-Tetrachloroethane
1 1
1 6302061
1 1
I I
1
1
1
1
ICARCzC
ICT-I.D.
¦
10
CARC
Note
15
1,1,2,2-Tetrachloroethane
1 1
1 79345110-1 (B)
I l
I I
1
IRat-ihl :LCLo: 1000/tH(D)
lDog-orli LDLo:300(D)
I
1
IL0W 100
ICT=17.5(C)
1
100
AQTX.CARC
Note
10
Tetrachloroethene
1 \
1 1271841100-10 (C)
1 1
1 1
1
IMus-orl18100(D)
1 Ra t-ihl: LCLo: M000/ MH (D)
<
1
IL0W 100
|CT=10(C)
1
100
CARC
Tetrachloroethylene
1 1
1 12718m 100-10 (C)
I I
1
IMus-orl:8100(D)
IRat-ihl: LCLo: I|000/4H(D)
1
1
lLOW 100
|CT=10(C)
1
100
CARC
Thloaeetamlde
I I
I 625551
1
IRat-orl:200(D)
1
1
IMED 10
¦
Solid
10
CARC
Thiourea
| |
! 625661 '
1 I
1
IRat-orl: 125(D)
1
1
IMED 10
1
Solid
10
CARC
Toluene-2, U-diamine
1 1
1 958071
1
IRat-orl: 260(D)
1
lLOW 100
l
Solid
100
CARC
o-Tolui dine hydrochloride
| |
1 6362151
I I
IRat-orl: 2951(D)
1
I
ILOW 100
1
Solid
100
CARC
Toxaphene
1 1
1 8001352|<0.1(X)
I I
I I
I |
1
IRat-orl:40(C)
iRat-skn: 600(D)
iDog-orl:15(C)
1
I
ILOW 100
1
1
1
Solid
1
1
311
Note
10
1H-1,2, 4-T rlazol- 3-amine
I 618251
1 1
1
IRat-orl:1100(D)
1
1
lLOW 100
1
Solid
100
CARC
111,2-Trichloroethane
1 1
1 790051100-10 (C)
1 1
1 1
1
IRat-orl: nH0(D)
1 Rat-ihl: LCLo: 500/8H (D)
1
1
lLOW 100
ICTrl.D.
1
100
CARC
Trichloroethene
1 1
1 790161 100-10 (C)
I I
I I
1
IRat-orl:H920(D)
1
1
1
lLOW 100
ICTi20(C )
1
F 90(C)
B 188
1000
100
CARC
RQTBL/CARC0185A.DTB/CONDATA.HED/12-APR-85 12:16:OH
-------
DATA FOB THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Mote 1)
1 1
1 1 Aquatic
I 1 Toxicity
1 CASRN 1 (Note 2)
1 Mammalian Toxicity (Note 3)
1 Chronic
( Toxicity/
ICarcinogen
1 (Note M)
Ignitability/
Reactivity
(Note 5)
311
RQ
Note 6)
1
Proposed I Basis for
RQ 1 Proposed RQ
(Note 7)1 (Note 8)
Ccmnents
Trichloroethylene
1 1
1 790161100-10 CC)
I 1
1 |
|Rat-orlsH920(D)
1
ILOU 100
|CT= 20(C)
I
F 90(C)
B 188
1000
100
I
ICABC
I
i
Tri chl orophenol
1 1
12516782211-0.1 (A)
1 |
1
|L0U 100
i
Solid
10
10
1311
1
Note 35
2,3, 4-TricW. orophenol
1159506601
| |
l
1
i
10
10
1311
1
2,3,5-Trl chlorophenol
1 9337861
| |
i
1
1
10
10
1311
|
2,3,6-T ri chl orophenol
1 9337551
i
i
10
10
1311
1
2, U, 5-Trichloro phenol
1 |
1 9595HI0.1-1(A)
1
)Rat-orl:820(D)
|
|CT= 13(C)
1
Solid
10
10
1311
i
2,M,6-Trichlorophenol
1
I 88062)1.0-1 (A)
I I
i i
iRat-orl:820(D)
1
|L0W 100
|CTsI.D.
1
Solid
10
10
1311
1
¦
3, *415-Trl chl orophenol
I
1 6091981
t
1
1
\
10
10
i
1311
1
2,4,5-Trichlorophenol
i
1 9595110.1-1(A)
IRat-orl: 820(D)
i
lCT=13(C)
i
Solid
10
10
1311
I
2,6-Trl chlorophenol
1 |
1 8806211.0-1 (A)
1 1
IRat-orl: 820(D)
1
IL0W 100
|CT=I.D.
I
Solid
10
10
1311
I
|
Trls(2,3-dlbromopropyl) phosphate
| |
I 1267271
| |
IRat-orl; 1010(0)
I
ILOW 100
1
100
1
ICAHC
1
Trypan blue
1 725711
1 |
l
ILOW 100
|
Solid
100
I
ICARC
i
Unlisted Hazardous Wastes
Characteristic of EP Toxicity
Arsenic DOOM
CadmiuD D006
Chromlun(VI) D007
Lead D008
Lindane D013
Toxaphene DO15
i i
i i
i i
i i
i i
i i
i i
i i
i i
i |
I
1
1
1
1
I
1
1
1
|
1
10
10
100
1
1
i
1
1
ICARC
ICARC
ICARC
ICTX
1311
1311
I
Uracil, 5-[bis(2-chloroethyl )amlno]-
1 667511
lRat-orl:7.5(B)
1
ICARC=c
i
Solid
10
1
ICARC
I
Note 15
Uracil mustard
| |
1 667511
1 1
lRat-orl:7.5(B)
1
ICARC=c
1
Solid
10
1
ICARC
1
Note 15
Vinyl chloride
1 1
i 7501111000 (D)
I 1
1 1
lRat-orl:500(D)
lGpg-ihl:LCLo: 20/3CM(B)
1
ILOW 100
ICT=20(C)
1
F GAS(B)
B 7
100
1
ICARC.I,
iT(lhl)
1
Note 36
RGTBL/CARC0185A .DTB/CONDATA .HED/12-APR-85 12:16:04
-------
DATA POT THE NPRM HAZARDOUS SUBSTANCES - Continued
I
1 Chronic
1 Aquatic
1 Toxicity/
Ignitabllity/
311
Proposed
Basis for
1 Toxicity
ICarclnogen
Reactivity
RQ
RQ
Proposed RQ
Hazardous Substance (Note 1)
CASRN 1 (Note 2)
1 Mammalian Toxicity (Note 3)
1 (Note U)
(Note 5)
(Note 6)
(Note 7)
(Note 8)
Comnenta
Vinylidene chloride
1
7535M11000-100
iRat-orl:200(D)
ILCM 100
F Q(B)
5000
100
CARC,I
Note 26
1(D)
iRat-ihl: 10,000/2tH(D)
|CT=19(C)
B 99
1
1
tMus-iKl:LC50:98 pjm/22H(C)
F001
1
1
10
Component
The following spent halogenated
1
solvents used In degreasing and sludges
1
from the recovery of these solvents in
1
degreaslng operations:
1
(a) Tetrachloroethylene
127l8tl
100
CARC
(b) Trichloroethylene
790161
1000
100
CARC
(c) Methylene chloride
750921
1000
CTX
(d) 1,1,1-Trlchloroethane
715561
1000
AffFX.CTX
(e) Carbon tetrachloride
562351
5000
10
CARC
(f) Chlorinated fluorocartons
N.A.I
1
5000
Max
Note 37
F002
1
1
100
Components
The following spent halogenated
1
solvents and the still bottoms from the
1
recovery of these solvents:
1
(a) Tetrachloroethylene
127181)1
100
CARC
(b) Methylene Chloride
750921
1000
CTX
(c) Trichloroethylene
790161
1000
100
CARC
(d) 1,1,1-Trichloroethane
715561
1000
AQTX.CTX
(e) Chlorobenzene
1089071
100
100
311
(f) 1,1,2-Triehloro-1,2,2-
761311
5000
Max
Note 37
trifluoroethane
I
(g) o-Dlchlor-o benzene
955011
100
100
311
(h) Trichlorofluoromethane
7569HI •
1
5000
Max
RQTBL/CARC01I85A .DTB/CONDATA .HED/12-APR-85
12:16:(W
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
I Chronic
1
I
Aquatic
1 Toxicity/
Ignltability/| 311
Proposed I Basis for
Toxicity
ICarcinogen
Beactivity I RQ
RQ
1Proposed RQ
Hazardous Substance (Note 1)
CASRN
(Note 2)
Mammalian Toxicity (Note 3) 1 (Note if)
(Note 5) I(Note 6)
(Note 7)1 (Note 8)
Connents
F006
1
1
1
10
1
1Components
Wastewater treatment sludges fran
1
1
1
electroplating operations except from
1
1
1
the following processes: CD sulfuric
1
1
1
acid anodizing of aluninun; (2) tin
1
1
1
plating on carbon steel; (3) zinc
1
1
1
plating
1
1
1
(segregated basis) on carbon steel; (1)
1
1
1
aluminum or zlno-aluninun plating on
1
1
1
carbon steel; (5) cleaning/stripping
1
1
1
associated with tin, zinc and aluninun
1
1
1
plating on carbon steel; and
1
1
1
(6) chemical etching and milling of
1
1
1
aluninun
1
1
1
(a) Cadmiun can pounds
N.A.
1
1
10
ICARC ,CTX
(b) Hexavalent chranlun compounds
N.A.
1
1
10
ICARC
(c) Nickel compounds
N.A.
1
1
10
lAQTX.CARC,
1
1
ICTX
(d) Cyanides (complexed)
N.A.
1
1
1 [10]
i
10
1311
I
Note 33
F019
1
1
1
1
10
I
1 Components
Wastewater treatment sludges fran the
1
1
1
chemical conversion coating of aluninun
1
1
1
(a) Hexavalent chranlun compounds
N.A.
1
1
10
ICARC
(b) Cyanides (canplexed)
N.A.
1
1
1 [10]
1
10
1311
1
Note 33
RQTBL/CARC0185A.DTB/CONDATA.HED/12-APR-85
12:16:0M
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
CASRN
Aquatic
Toxicity
(Note 2)
Mammalian Toxicity (Note 3)
Chronic
Toxicity/
arcinogen
(Note H)
gnitability/
Reactivity
(Note 5)
311
RQ
Note 6)
Proposed
RQ
(Note 7)
Basis for
roposed RQ
(Note 8)
Comments
F020
Wastes (except wastewater and spent
carbon from hydrogen chloride
purification) from the production or
manufacturing use (as a reactant,
chemical intermediate, or component in
a formulating process) of tri- or
tetrachlorophenol,
or of intermediates used to produce
their pesticide derivatives. (This
listing does not include wastes from
the production of Hexachlorophene from
highly purified 2,i),5-trichlorophenol.)
(a) Tetrachlorodibenzo-p-dioxins
21317 ,8-Tetrachlorodi benzo-p-
dioxln (TCDD)
(b) Pentachlorodibenzo-p-dioxins
(c) Tetrachlorodibenzofurans
2,3,7,8-Tetrachlorodibenzofuran
(d) Pentachlorodibenzofurans
(e) Tetrachlorophenols and their
chlorophenoxy derivative acids,
esters, ethers,amine
and other salts.
2»3,116-Tetrachlorophenol
(f) Trichlorophenols and their
chlorophenoxy derivative acids,
esters, ethers, amine
and other salts.
2, , 5-Trichlorophenol
2,1), 6-Trichlorophenol
1
Components
1716016
N.A
51207319
58902
9595
8806
<0.1(X)
Mus-orl:0.114(A)
Mus-skin:LDlo:80 ug/kg(A)
Dog-orl:LDlo:3(B)
Gpg-orl:5 ug/kg(X)
HIGH 1
1-0.1(A)
0.1-1(A)
1-0.1(A)
Rat-orl:1M0(D)
Rbt-skn:250(D)
Rat-orl:820(D)
Rat-orl:820(D)
CT=32(B)
CT=13(C)
LOW 100
CT=I.D.
Solid
Solid
Solid
10
10
10
10
10
AQTX,CARC
T(orl)
AOTX
311
311
RQTBL/CARCM85A.DTB/CONDATA.HED/12-APR-85 12:16:04
-------
DATA FOR THE HPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Mote 1)
CASRN
Aquatic
Toxicity
(Mote 2)
Mammalian Toxicity (Hote 3)
Chronic
Toxicity/
Carcinogen
(Note J))
gnitabillty/
Reactivity
(Note 5)
311
RQ
Note 6)
Proposed
RQ
(Note 7)
Basis for
"roposed RQ
(Mote 6)
Caiments
F021
Wastes (except wastewater and spent
carbon from hydrogen chloride
purification) from the production or
manufacturing use (as a reactant,
chemical intermediate, or component in
a formulating process) of
pentachlorophenol, or of
intermediates used to produce its
derivatives.
(a) Pentachlordibenzo-p-dioxlns
(b) Hexachlorodibenzo-p-dloxins
1,2,3,7,8,9-He3BcHlorodl benzo-p-
dloxln
Hexachlorodi benzo-p-dloxln
1,2,3,1,7,8-Hexachlorodlbenzo-p-
dioxin
(c) Pentachlorodibenzofurana
(d) Hexachlorodibenzofurans
(e) Pentachlorophenol and its
derivatives.
F022
Wastes (except wastewater and spent
carbon from hydrogen chloride
purification) from the manufacturing
use (as a reactant, chemical
intermediate, or component in a
formulating process) of tetra-,
penta-, or hexachlorobenzenes under
altaline conditions.
(a) Tetrachlorodlbenzo-p-dloxins
2,3,7,8-Tet ra chl orodl be nzo- p- di oxi n
(TCDD)
(b) Pentachlorodibenzo-p-dioxlns
(c) Hexachlorodibenzo-p-dioxins
1,2,3,7,8,9-Hexachlorodi benzo-p-
dloxln
Hexaehloro-p-dioxin
1,2,3,1,7,8-Hexachlorodibenzo-p-
dioxln
(d) Tetrachlorodlhenzofurans
5,3,7 ,S- Ter f-achl ^rwlibenzofuran
(e) Pentachlorodibenzofurans
(f) Hexachlorodi benzofurans
191087*13
31165168
39227286
87865
0.2-0.6(A)
1716016
19108713
31165168
39227286
5127319
<0.1(X)
Components
Gpg-orl:60 ug/kg(X)
Mus-orlj 1250 ug/kg(B)
Gpg-orl;70 ug/kg(X)
Mus-orli825 ug/kg(A)
Gpg-orl:72.5 ug/kg(X)
Rat-orl; 50(C)
Rat-lhl! 11.7(B)
Rat-skn: 105(D)
CT=20(C)
Solid
10
1
1
1
10
T(orl)
T(orl)
T(orl)
311
Components
Mus-skn:LDloj80 ug/kg(A)
Dog-orl;LDlo:3(B)
Mus-orl;0.111(A)
Gpg-orl;60 ug/kg(X)
Hus-orl:1250 ug/kg(B)
Gpg-orl:70 ug/kg(X)
Hus-orl-.825 ug/kg(A)
Gpg-orl:72.5 ug/kg (X)
Gpg-orl:5 ug/kg(X)
HIGH 1
AQTX.CARC
T(orl)
T(orl)
T(orl)
T(orl)
RQTBL/CARC01B5A.DTB/C0NDATA.HED/12-APR-&5 12:16:01
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
CASRN
Aquatic
Toxicity
(Note 2)
Mammalian Toxicity (Note 3)
Chronic
Toxicity/
Carcinogen
(Note
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
I Aquatic
I Toxicity
CASRN I (Note 2)
Mammallan Toxicity (Note 3)
Chronic
Toxicity/
Carcinogen
(Note 1)
gnitaDility/
Reactivity
(Note 5)
311
Proposed
Basis for
RQ
RQ
'roposed RQ
ote 6)
(Note 7)
(Note 8)
1
Components
100
I
1000
CTX
5000
100
CARC
5000
10
CARC
100
CARC,I,
T(ihl)
1000
CTX,I
5000
100
CARC
1000
I,CTX
5000
100
CARC,I
1000
AQTX.CTX
100
CARC
1000
100
CARC
10
CARC
100
acttx.carc
100
CARC
10
AQTX
100
AQTX.CARC
1000
1000
311 ,T(orl)
T(lhl),I
5000
1000
I,CS
5000
100
AQTX.CTX
1000
AQTX,I
1
AQTX
1
1
311
1
1
311
1000
100
AQTX.CARC
100
100
311
100
100
311
100
AQTX
5000
CTX
1000
CTX
10
CARC
1000
1000
311,1,CTX
5000
100
AQTX
Comments
U>
I
ro
oo
F021
Wastes, including but not limited to,
distillation residues, heavy ends,
tars, and reactor cleanout wastes, fran
the production of chlorinated aliphatic
hydrocarbons, having carbon content
fran one to five, utilizing free
radical catalyzed
processes. (This listing does not
include light ends, spent filters and
filter aids, spent dessicants(sic),
wastewater, wastewater treatment
sludges, spent catalysts, and wastes
listed in Section 261.32.).
a) Chlorxxnethane
b) Dlchloromethane
c) Trlchloromethane
d) Carbon tetrachloride
e) Chloroethylene
f) 1,1-Dlchloroethane
g) 1,2-Dichloroethane
h) trans-1,2-Dichloroethylene
i) 1,1-Dichloroethylene
j) 1,1,1-Trichloroethane
k) 1,1,2-Trichloroethane
1) Trichloroethylene
m) 1,1,1,2-Tetrachloroethane
n) 1,1,2,2-Tetrachloroethane
o) Tetrachloroethylene
p) Pentachloroethane
q) Hexachloroethane
r) Allyl chloride (3-chloropropene)
s) Dichloropropane
t) Dichloropropene
u) 2-Chloro-1,3-butadiene
v) Hexachloro-1,3-butadlene
w) Hexachlorocyclopentadiene
x) Hexachlorocyclohexane
y) Benzene
z) Chiorobenzene
aa) Dichl orobenzenes
bb) 1,2,4-Tri chl oro benzene
2c) Tetrachlorobenzene
dd) Pentachlorobenzene
ee) Hexachloro benzene
ff) Toluene
(ig) Naphthalene
I
I
718731
750921
676631
562351
750111
I
753*131
1070621
1566051
753511
715561
790051
790161
6302061
793151
1271811
760171
677211
1070511
I
266381971
269522381
1269981
876831
771711
588991
711321
1089071
253212261
1208211
959131
6089351
1187111
1088831
912031
I
Note 15
RQTBL/CARC0185A .DTB/C0HDATA .HED/12-APR-85 12:16:01
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
CASRN
Aquatic
Toxicity
(Note 2)
Mammalian Toxicity (Note 3)
Chronic
Toxicity/
Carcinogen
(Note !()
Ignitability/
Reactivity
(Note 5)
311
HQ
(Note 6)
Proposed
RQ
(Note 7)
Basis for
Proposed RQ
(Note 6)
Comments
F026
Wastes (except wastewater and spent
carbon from hydrogen chloride
purification) from the production of
materials on equipment previously used
for the manufacturing use
(as a reactant, chemical intermediate,
or component in a formulating process)
of tetra-,penta-, or he xachloro benzene
under alkaline conditions.
(a) 7etrachlorodibenzo-p-dicxins
2i3,7iS-Tetrachlorodibenzo-p-dioxin
(TCDD)
(b) Pentachlorodibenzo-p-dioxins
(c) Hexachlorodibenzo-p-diojdns
1 >2,3,7,8,9-Hexachlorodibenzo-p-
dioxln
Hexachloro-p-dioidn
1,2,3,t,7,8-Hexachlorodibenzo-p-
dioxin
(d) Tetrachlorodibenzofurans
2,3.71B-Tetrachlorodibenzofuran
(e) Pentachlorodibenzofurans
(f) Hexachl orodi benzofurans
17^6016
19108713
31165H68
39227286
51207319
<0.1(X)
1
Mus-orl:0.111(A)
Mu3-skn:LDlo:80 ug/kg(A)
Dog-orl:LDlo:3(B)
Gpg-orl:60 ug/kg(X)
Mus-orl:1250 ug/kg(B)
Gpg-orl:70 ug/kg (X)
Mua-orl:B25 ug/kg (A)
Gpg-orl:7205 ug/kg(X)
Gpg-orl:5 ug/kg(X)
HIGH 1
Components
AQTX,CARC
T(orl)
T(orl)
T(orl)
T(orl)
RQTBL/CARC0185A.DTB/CONDATA.HED/12-APR-85 12:16:04
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
1
1 Chronic
1
1
Aquatic
I Toxicity/
Ignitability/
311
Proposed
Basis for I
1
Toxicity
1Carcinogen
Reactivity
RQ
HQ
Proposed RQ|
Hazardous Substance (Note 1)
1 CASRN
(Note 2)
Mammalian Toxicity (Note 3)
1 (Note 4)
(Note 5)
Note 6)
(Note 7)
(Note 8) IConrnents
F027
1
1
1
1
Components I
Discarded unused formulations
1
1
containing trl-, tetra-, or
1
1
pentachlorophenol or discarded unused
1
1
formulations containing compounds
1
1
derived from these chlorophenols.
1
1
(This listing does not
1
1
include formulations containing
I
1
Hexachlorophene synthesized from
1
1
prepurified 2,4,5-trichlorophenol as
1
1
the sole component.).
1
1
(a) Tetrachlorodibenzo-p-dioxin3
1
1
2 > 3171 &-Tetrachl orodi benzo- p-
1 17^6016
<0.1(X)
Mus-orl: 0.114(A)
IHIGH 1
1
AQTX ,CARC I
dioxin (TCDD)
1
1
Mus-skn:LDlo:80 ug/kg(A)
Dog-orl:LDlo:3(B)
1
1
(b) Pentachloro di benzo-p-dioxins
1
1
(c) Hexachlorodibenzo-p-dioxins
1
1
T(orl) I
1|2,3,7,8,9-Hexachlorodibenzo-p-
I 19408743
Gpg-orl:60 ug/kg(X)
1
dioxin
1
1
Hexa chlorodi benzo- p-dioxin
134U65H68
1
Mus-orl: 1250 ug/kg(B)
Gpg-orl:70 ug/kg(X)
1
T(orl) I
1
1,2,3,1,7,8-Hexachlorodibenzo-p-
139227286
Mus-orl: 825 ug/kg(A)
1
T(orl) 1
dioxin
1
Gpg-orl:72.5 ug/V
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
1
1 Chronic
1
1
Aquatic
1 Toxicity/
Ignitability/
311
Proposed
Basis for 1
1
Toxicity
ICarcinogen
Reactivity
RQ
RQ
>ro posed RQ|
Hazardous Substance (Note 1)
1 CASRN
(Note 2)
Mammalian Toxicity (Note 3)
1 (Note 4)
(Note 5)
(Note 6)
(Note 7)
(Note 8) IComments
F028
1
1
1
1
Components 1
Residues resulting from the
1
1
incineration or thermal treatment of
1
1
soil contaminated with EPA Hazardous
1
1
Uaste Nos. F020, F021, F022, F023,
1
1
F026, and F027.
1
1
(a) Tetrachlorodibenzo-p-dioxins
1
1
2,3,718-Tetrachlorodibenzo-p-
1 1716016
<0.1(X)
Mus-orl:0.114(A)
IHIGH 1
1
AQTX,CARC 1
dioxin (TCDD)
1
1
Mus-skn:LDlo 80 ug/kg(A)
Dog-orl:LDlo:3(B)
1
1
(b) Pentachlorodibenzo-p-dioxins
1
1
(c) Hexachlorodi benzo-p-dioxim
1
1
112,3 > 7,8,9-He xa chl orodi- benzo- p-
1191087 >43
Gpg-orl:60 ug/kg(X)
1
T(orl) 1
dioxin
1
1
Hexachlorodibenzo-p-dioxlns
I31165M68
1
Mus-orl:1250 ug/kg(B)
Gpg-orl: 70 ug/kg(X)
1
T(orl) I
1
1,2,3 > 17,8-Hexachlorodl benzo- p-
1
Mus-orl: 825 ug/kg(A)
1
T(orl) I
dloxln
1 3977286
Gpg-orl:72.5 ug/kg(X)
1
(d) Tetrachlorodibenzofurans
1
1
2,3,7,8-Tetrachlorodibenzofuran
157207319
Gpg-orl: 5 ug/kg(X)
1
T(orl) 1
(e) Pentachlorodibenzofurans
1
1
(f) Hexachlorodibenzofurans
1
1
(g) Trichlorophenols and their
1
1
chlorophenoxy derivative acids,
1
1
esters,ethers, amine
1
1
and other salts.
1
1
2, if, 5-Trichlorophenol
1 95954
0.1-1(A)
Rat-orl:820(D)
ICTs 13(C)
Solid
10
10
311 I
2,U,6-Tri chlorophenol
1 88062
1
0.1-KA)
Rat-orl: 820(D)
I LOW 100
ICTiI.D.
Solid
10
10
311 1
1
(h) Tetrachlorophenols and their
1
1
chlorophenoxy derivative acids,
1
1
esters,ethers, amine
1
1
and other salts.
1
1
2i3i1,6-Tetrachlorophenol
1 58902
1
0.1-KA)
Rat-orl: 1M0(D)
Rbt-Skn:250(D)
|CT=32(B)
Solid
10
AQTX I
1
(i) Pentachlorophenols and their
1 87865
0.2-0.6(A)
Rat-orl:50(C)
|CT=20(C)
Solid
10
10
311 1
chlorophenoxy derivative acids,
1
Rat-ihl:11.7(B)
1
esters,ethers, amine
1
Rat-skn:105(D)
1
and other salts.
1
1
1
I
RQTBL./CARC0485A.DTB/COHDATA.HED/12-APR-85 12:16:04
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
1
1 Chronic
I
1
Aquatic
1 Toxicity/
Ignitability/
311
Proposed) Baals for
1
Toxicity
ICarcinogen
Reactivity
RQ
RQ
I Proposed RQ
Hazardous Substance (Note 1)
CASRN 1
(Note 2)
Mammalian Toxicity (Note 3) 1 [Note 1)
(Note 5)
Note 6)
(Note 7)
I (Note 8)
Comments
K001
1
1
1
1
10
I
I Components
SEE K069
Bottom sediment sludge from the
1
1
I
treatment of wastewaters from wood
1
1
I
preserving processes that use creosote
1
1
I
and/or pentachlorophenol
1
1
I
(a) Pentachlorophenol
878651
1
10
10
1311
(b) Phenol
1089521
1
1000
1000
IBHP
(c) 2-Chlorophenol
955781
1
100
IAQTX
(d) p-Chloro-m-cresol
595071
1
5000
iT(orl)
(e) 2,4-Dinitrophenol
512851
1
1000
10
IAQTX
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
CASRN
Aquatic
Toxici ty
(Note 2)
Mammalian Toxicity (Note 3)
Chronic
Toxicity/
Carcinogen
(Note H)
Igni tability/
Reactivity
(Note 5)
311
RQ
[Note 6)
Proposed
RQ
(Note 7)
Basis for
Proposed RQ
(Note 8)
Comments
K005
Wastewater treatment sludge from the
production of chrome green pignents
(a) Hexavalent chromlun compounds
(b) Lead compounds
K006
Wastewater treatment sludge from the
production of chrome oxide green
pigments (anhydrous and hydrated)
(a) Hexavalent chromlun compounds
K007
Wastewater treatment sludge from the
production of iron blue pigments
(a) Cyanide (ccmplexed)
(b) Hexavalent chromlun compounds
K008
Oven residue from the production of
chrome oxide green pigments
(a) Hexavalent Chromium Can pounds
K009
Distillation bottoms from the
production of acetaldehyde from ethylene
(a) Chloroform
(b) Formaldehyde
(c) Methylene chloride
(d) Methyl chloride
(e) Paraldehyde
(f) Formic acid
K010
Distillation side cuts from the
production of acetaldehyde from ethylene
(a) Chloroform
(b) Formaldehyde
(c) Methylene chloride
(d) Methyl chloride
(e) Paraldehyde
(f) Formic acid
(g) Chloroacetaldehyde
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
67663
50000
75092
7*)873
123637
61)186
67663
50000
75092
7W3
123637
61)186
107200
[10]
5000
1000
5000
5000
1000
5000
10
10
100
10
10
10
10
10
10
10
100
100
100
1000
100
1000
5000
100
100
100
1000
100
1000
5000
1000
Components
CARC
CTX
Components
CARC
Components
311
CARC
Components
CARC
Components
CARC
CARC,CTX,I
CTX
I
I
311
Components
CARC
CARC,CTX,I
CTX
I
I
311
T(orl)
Note 33
RQTBL/CARC0l)85A .DTB/COIJDATA .HED/12-APR-85 12:16:0M
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
1 1
1 Chronic
1 1
1 1
Aquatic
1 Toxicity/
Ignltability/
311
Proposed
1 Basis for |
1 1
Toxicity
ICarcinogen
Reactivity
RQ
RQ
1Proposed RQl
Hazardous Substance (Note 1)
1 CASRN I
(Note 2)
Mammalian Toxicity (Note 3) 1 (Note 1)
(Note 5)
(Note 6)
(Note 7)
1 (Note 8) ICoraments
K011
1 1
1 1
1
1
10
1 1
ICoraponent |
Bottom stream from the wastewater
1 1
1
1 1
stripper in the production of
1 1
1
1 1
acrylonitrile
1 1
1
1 1
(a) Acrylonltrile
1 1071311
1
100
100
I311.CARC, I
1 1
1
ICTX I
(b) Acetonitrile
1 750581
1
5000
IBHP I
(c) Hydrocyanic acid
1 71908I
1 1
1
1
10
10
1311,R I
1 |
K013
1 1
1 1
1
1
10
1 1
1Component I
Bottom stream from the acetonitrile
1 1
1
1 1
colunn in the production of
1 1
1
1 1
acrylonltrile
1 1
1
1 1
(a) Acrylonltrile
1 1071311
1
100
100
I311.CARC, 1
1 1
1
ICTX |
(b) Acetonitrile
1 750581
1
5000
IBHP |
(c) Hydrocyanic acid
1 719081
1 1
1
1
10
10
1311,R 1
1 1
K015
1 1
1 1
1
1
10
1 1
1Components 1
Still bottoms fran the distillation of
1 1
1
1 1
benzyl chloride
1 1
1
1 1
(a) Benzyl chloride
1 1001171
1
100
10
ICARC I
(b) Chlorobenzene
1 1089071
1
100
100
1311 I
(c) Toluene
1 1088831
1
1000
1000
I311.I.CTX 1
(d) Benzotrichloride
1 980771
1 1
1
I
10
ICARC I
I I
K016
1 1
1 1
I
1
1
1 I
1Component I
Heavy ends or distillation residues
1 1
1
1 1
from the production of carbon
1 1
I
1 1
tetrachloride
1 1
1
1 1
(a) Hexachloro benzene
1 1187111"
1
10
ICARC 1
(b) Hexachlorobutadiene
1 876831
1
1
lAQTX I
(c) Carbon tetrachloride
1 562351
1
5000
10
ICARC 1
(d) Hexachloroethane
1 677211
1
100
lAQTX,CARC I
(e) Perchloroethylene
1 1271811
1 1
1
1
100
ICARC I
1 1
ROTBL/CARC0185A.DTB/COHDATA.HED/12-APR-85
12:16:01
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
1 1
1 Chronic
I
1 1
Aquatic
1 Toxicity/
Ignitability/
311
Proposed| Basis for
1 1
Toxicity
ICarcinogen
Reactivity
RQ
RQ
1Proposed RQ
Hazardous Substance (Note 1)
1 CASRN 1
(Note 2)
Mammalian Toxicity (Note 3) 1 (Note 4)
(Note 5)
Note 6)
(Note 7)1 (Note 8)
Comments
K017
1 1
t 1
1
10
1
1 Components
Heavy ends (still bottoms) from the
1 1
1
1
purification eolunn in the production
1 1
1
1
of epichlorohydrin
1 1
1
1
(a) Epichlorohydrin
1 1068981
1
1000
100
ICARC ,CTX
(b) bis (Chloromethyl ether)
I 5128811
1
10
IBHP
(c) bis (2-Chloroethyl ether)
I mini
1
10
ICARC
(d) Trichloropropane
1 1
1
1
(1) 1,2,3 isomer
1 961841
1
5000
iT(orl)
Note 38
1 1
1
iT(ihl)
(e) Dichloropropanol
1 t
1
1
(1) n-,2,3 iscmer
1 6162391
1
1000
iT(orl)
Note 39
1 I
1 I
1
I
iT(ihl)
K018
1 I
1 1
1
1
1
1
ICcmponent
Heavy ends from the fractionation
1 1
1
1
eolunn in ethyl chloride production
1 1
1
1
(a) 1,2-Dichloroethane
1 1070621
1
5000
100
ICARC
(b) Trichloroethylene
1 790161
1
1000
100
ICARC
(c) Hexachloro butadiene
1 876831
1
1
IAQTX
(d) Hexachlorobenzene
1 1187111
| 1
1
|
10
ICARC
I
K019
1 1
1 1
1
1
10
1
IComponents
Heavy ends from the distillation of
1 1
1
1
ethylene dichloride in ethylene
1 1
1
1
dichloride production
1 1
1
1
(a) Ethylene dichloride
1 1070621
1
5000
100
ICARC
(b) 1,1,1-Triehloroethane
1 715561
1
1000
IAQTX ,CTX
(c) 1,1,2-Trichloroethane
1 790051
1
100
ICARC
(d) 1,1,1,2-Tetrachloroethane
1 6302061
1
10
ICARC
(e) 1,1,2,2-Tetrachloroethane
1 793151
1
100
IAQTX,CARC
(f) Trichloroethylene
1 790161
1
1000
100
ICARC
(g) Tetrachloroethylene
! 1271811
1
100
ICARC
(h) Carbon Tetrachloride
1 562351
1
5000
10
ICARC
(i) Chloroform
1 676631
1
5000
100
ICARC
(J) Vinyl chloride
1 750141
1
100
lT(ihl),
1 1
1
ICARC,I
(k) Vinylidene chloride
1 753511
1 i
1
|
5000
100
ICARC,I
1
K020
i i
1 1
1
1
10
1
1Components
SEE K019
Heavy ends from the distillation of
1 1
1
1
vinyl chloride in vinyl chloride
1 1
1
1
monomer production
! 1
1
1
(a) Components of this waste are
1 1
1
1
identical with those of KOI 9,
1 1
1
1
immediately preceding
1
1
1
1
1
1
RQTBL/CARC0185A .DTB/CONDATA .HED/12-APR-85 12:16:014
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
I
1 Chronic
I
Aquatic
1 Toxicity/
Ignitabllity/
311
Proposed
Basis for
I
Toxicity
ICarcinogen
Reactivity
RQ
RQ
'roposed RQ
Hazardous Substance (Note 1)
CASRN I
(Note 2)
Mammalian Toxicity (Note 3) I (Note 1)
(Note 5)
(Note 6)
(Note 7)
(Note 8)
Comments
K021
I
I
1
1
10
Component
Aqueous spent antimony catalyst waste
I
1
from fluorcmethanes production
1
1
(a) Antimony Trichloride
100259191
1
1000
1000
311
Note 10
(b) Carbon Tetrachloride
562351
1
5000
10
CARC
(c) Chloroform
676631
¦
1
I
5000
100
CARC
K022
1
1
1
1
1
Component
Distillation bottom tars from the
1
1
production of phenol/acetone from cunene
1
1
(a) Phenol
1089521
1
1000
1000
BHP
(b) Tars (polycyclic aromatic)
N.A. 1
1
1
I
1
CARC
Note 111
K025
I
1
1
1
100
Ccmponents
Distillation bottoms from the
1
1
production of nitrobenzene by the
1
1
nitration of benzene
1
1
(a) meta-Dinitrobenzene
996501
1
1000
100
CTX
(b) 2,4-Dinitrotoluene
1211H2I
1
1
1000
100
CARC.CTX
K027
1
1
1
1
100
Ccmponents
Centrifuge and distillation residues
1
1
from toluene diisocyanate production
1
1
(a) Toluene diisocyanate
58W9I
1
100
AQTX,
1
1
T(ihl)
(b) Toluene-2,4-diamine
958071
1
1
100
CARC
K028
1
1
1
1
100
Component
Spent catalyst from the
1
1
hydrochlorinator reactor in the
1
1
production of 1,1,1-trichloroethane
I-
1
(a) 1,1,1-Trichloroethane
715561
1
1000
AQTX,CTX
(b) Vinyl chloride
7501HI
1
100
T(ihl),
I
1
1
CARC,I
K029
1
1
1
1
100
Components
Waste from the product steam stripper
1
1
in the production of 1,1,1-
1
1
trichloroethane
1
1
(a) 1,2-Dichloroethane
1070621
1
5000
100
CARC
(b) 1,1,1-Trichloroethane
715561
1
1000
AQTX,CTX
(c) Vinyl chloride
750111
1
100
T(ihl),
1
1
CARC,I
(d) Vinylidene chloride
7535*41
1
5000
100
CARC,I
(e) Chloroform
676631
1
1
1
5000
100
CARC
RQTBL/CARC0185A.DTB/C0HDATA.HED/12-APR-85 12:l6:0H
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
I
1 Chronic
1 1
I
Aquatic
1 Toxicity/
Ignitability/
311
Proposed I Basis for I
I
Toxicity
iCarcinogen
Reactivity
RQ
RQ
1Proposed RQ1
Hazardous Substance (Note 1)
CASRN I
(Note 2)
Mammalian Toxicity (Note 3) 1 (Note 1)
(Note 5)
Note 6)
(Note
7)1 (Note 8) ICorauents
K030
I
I
1
1
1
1 1
1 Component 1
Coliran bottoms or heavy ends from the
I
1
1 1
combined production of
I
1
1 1
trlchloroethylene and perchloroethylene
I
t
1 1
(a) Hexachloro benzene
1187111
1
10
ICARC 1
(b) Hexachlorobutadiene
876831
1
1
IAQTX I
(c) Hexachloroe thane
677211
1
100
IAQTX,CARC 1
(d) 1,1,1,2-Tetrachloroethane
6302061
1
10
ICARC 1
(e) 1,1,2,2-Tetrachloroethane
793151
1
100
IAQTX,CARC I
(f) Ethylene dichloride
1070621
1
1
5000
100
ICARC 1
1 1
K031
1
1
1
1
1
1 1
1Components I
By-product salts generated in the
1
1
1 1
production of MSMA and cacodylic acid
1
1
1 1
(a) Arsenic compounds
N.A.I
|
1
|
1
ICARC 1
1 |
K032
1
1
1
1
1
1 1
1 Component |
Wastewater treatment sludge from the
1
1
1 1
production of chlordane
1
1
1 1
(a) Hexachlorocyclopentadlene
7717H
t
1
1
1
1
1311 I
| |
K033
1
1
1
1
1
1 1
1 Component I
Wastewater and scrub water from the
1
1
1 1
chlorination of cyclopentadiene in the
1
1
1 1
production of chlordane
1
1
1 1
(a) Hexachlorocyclopentadlene
771711
I
1
1
1
1
1311 I
1 1
K031
1
1
1
1
1
1 1
1 Component I
Filter solids from filtration of
1
1
1 1
hexachlorocyclopentadlene in the
1
1
1 1
production of chlordane
1
1
1 1
(a) Hexachlorocyclopentadlene
771711
|
I
1
1
1
1311 I
1 1
K035
1
1
1
1
1
1 1
1Components I
Wastewater treatment sludges generated
1
1
1 1
in the production of creosote
1
1
1 1
(a) Creosote
80015891
1
10
ICARC I
(b) Chrysene
2180191
1
100
ICARC I
(c) Naphthalene
912031
1
5000
100
IAQTX I
(d) Benzo(b)fluoranthene
2059921
1
1
ICARC I
(e) Fluoranthene
2061101
1
100
IAQTX I
(f) Benzo(a)pyrene
503281
1
1
ICARC I
(g) Indeno(1,2,3-cd)pyrene
1933951
1
10
ICARC 1
(h) Benz(a)anthracene
565531
1
10
ICARC I
(i) Dibenz(a,h)anthracene
537031
1
1
ICARC I
(J) Acenaphthalene
2089681
1
1
1
5000
I MAX |
1 1
RQTBL/CARC0185A.DTB/CONDATA.HED/12-APR-85 12:16:01
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
I Chronic
1
Aquatic
I Toxicity/
Ignitablllty/
311
Proposed I Basis for
Toxicity
iCarclnogen
Reactivity
RQ
RQ
1 Proposed R0
Hazardous Substance (Note 1)
CASRN
(Note 2)
Mammalian Toxicity (Note 3) I (Note M)
(Note 5)
[Note 6)
(Note 7)
I (Note 8)
Comments
K038
I
I
100
1
IComponent
Wastewater from the washing and
I
1
stripping of phorate production
I
1
(a) Phorate
298022
I
1000
IBHP
(b) Formaldehyde
50000
I
1000
100
ICARC.CTX.I
(c) Phosphorodithioic esters
N.A.
I
1000
IBHP
Note 142
(d) Phosphorothiolc esters
N.A.
I
1
1000
IBHP
1
Note 1)2
KO'tO
1
1
100
1
1 Component
SEE K038
Wastewater treatment sludge Tram the
1
1
production of phorate
1
1
Components of this waste Eire Identical
1
1
with those of K038, above.
1
1
|
K011
1
1
1
1
I Component
Wastewater treatment sludge from the
1
1
production of toxaphene
1
1
(a) Toxaphene
8001352
1
1
1
1
1311
K0U2
1
1
10
1
1 Component
Heavy ends or distillation residues
1
1
from the distillation of
1
1
tetrachlorobenzene in the production of
1
1
2,1,5-T
1
1
(a) Hexachlorobenzene
1187*41
1
10
ICARC
(b) Orthodichlorobenzene
95501
1
100
100
1311
1
K013
1
1
10
1
1 Component
2,6-Dichlorophenol waste frcm the
1
1
production of 2,4-D
1
1
(a) 2,4-Dichlorophenol
120832
1
100
IAQTX
(b) 2,6-Dichlorophenol
87650
1
100
IAQTX
(c) 2,14,6-Trichlorophenol
88062
1
1
10
10
1311
1
K0M8
1
1
10
1
(Components
Dissolved air flotation (DAF) float
1
1
from the petrol eon refining industry
1
1
(a) Hexavalent Chromium compounds
N.A.
1
10
ICARC
(b) Lead compounds
N.A.
1
|
100
ICTX
|
K0M9
1
1
10
I
1Components
Slop oil anulsion solids from the
1
1
petroleun refining Industry
1
1
(a) Hexavalent chromium compounds
N.A.
1
10
ICARC
(b) Lead compounds
N.A.
1
1
100
ICTX
1
RQTBL/CARC0M85A .DTB/OONDATA -HED/12-APR-85 12; 16:0U
-------
DATA FOR THE NPRM HAZARDOUS SUBSTANCES - Continued
I Chronic
1 1
Aquatic
I Toxicity/
Ignitability/
311
Proposed| Basis for I
Toxicity
ICarcinogen
Reactivity
RQ
RQ
1Proposed RQ|
Hazardous Substance (Note 1)
CASRN
(Note 2)
Mammalian Toxicity (Note 3) I (Note 4)
(Note 5)
iNote 6)
(Note 7)
1 (Note 8) ICcmments
K050
I
I
10
1 1
1 Components I
Heat exchanger bundle cleaning sludge
I
1 1
from the petroleum refining industry
I
1 1
(a) Hexavalent chromium compounds
N.A.
I
1
10
ICARC I
I 1
K051
1
1
10
1 1
IComponents I
API separator sludge from the petroleum
1
1 1
refining industry
1
1 1
(a) Hexavalent Chromium compounds
N.A.
1
10
ICARC I
(b) Lead compounds
N.A.
1
1
100
ICTX I
| 1
K060
1
1
1
1 1
IComponents I
Amnonia still lime sludge from coking
1
1 1
operations
1
1 1
(a) Cyanides
N.A.
1
[10]
10
1311 iNote 33
(b) Phenolic compounds
N.A.
1
1 1
[Phenol]
108952
1
1000
1000
IBHP I
(c) Naphthalene
91203
1
5000
100
IAQTX 1
(d) Arsenic compounds
N.A.
1
1
1
ICARC 1
I I
K061
1
1
10
1 I
IComponents I
Emission control dust/sludge from the
1
1 1
primary production of steel in electric
1
1 1
furnaces
1
1 1
(a) Hexavalent chromium compounds
N.A.
1
10
ICARC 1
(b) Lead (compounds)
N.A.
1
100
ICTX I
(c) Cadmium (compounds)
N.A.
1
1
10
ICARC ,CTX 1
I I
K062
1
1
10
1 1
IComponents 1
Spent pickle liquor from steel
1
1 1
finishing operations
1
1 1
(a) Hexavalent chromiun compounds
N.A.
1
10
ICARC 1
(b) Lead (compounds)
N.A.
1
1
100
ICTX I
1 1
K069
1
1
10
1 1
1 Components I
Emission control dust/sludge from
1
1 1
secondary lead smelting
1
1 1
(a) Hexavalent chromiun compounds
N.A.
1
10
ICARC I
(b) Lead (compounds)
N.A.
1
100
ICTX |
(c) Cadmium (compounds)
N.A.
1
1
10
ICARC ,CTX I
1 1
RQTBL/CARC0185A.DTB/COHDATA.HED/12-APR-85 12:16:04
-------
DATA FOR THE NPFH HAZARDOUS SUBSTANCES - Continued
1
1 Chronic
I
1
Aquatic
1 Toxicity/
Ignltability/
311
Proposed
Basis for I
1 Toxicity
1Carcinogen
Reactivity
RQ
RQ
Proposed RQ I
Hazardous Substance (Note 1)
CASRN 1
(Note 2)
Mammal lan Toxicity (Note 3) I (Note 1)
(Note 5)
Note 6)
(Note 7)
(Note 8) ICcraraents
K073
1
1
1
1
10
I
Component I
Chlorinated hydrocarbon waste from the
1
1
I
purification step of the diaphragm cell
1
1
I
process using graphite anodes In
1
1
I
chlorine production
1
1
I
CARC I
(a) Chloroform
676631
1
5000
100
(b) Carbon tetrachloride
562351
1
5000
10
CARC I
(c) Hexachloroe thane
677211
1
100
AQTX.CARC I
(d) Trlchloroethane
1
1
I
(1) 1,1,1-isomer
715561
1
1000
AQTX,CTX I
(2) 1,1,2-iscmer
790051
1
100
CARC I
(e) Tetrachloroethylene
1271811
1
100
CARC I
(f) Dichloroethylene
I
1
1000
I
I,CTX I
(1) trans 1,2-isaner
1566051
1
(g) 1,1,2,2-Tetrachloroethane
793151
1
1
I
100
AQTX.CARC I
|
K08t
1
1
1
1
1
Components I
Wastewater treatment sludges generated
1
1
I
during the production of veterinary
1
1
I
pharmaceuticals from arsenic or organo-
1
1
I
arsenic oompounds
1
1
I
(a) Arsenic (compounds)
N.A. I
1
1
1
CARC I
|
K085
1
1
1
1
10
Components I
Distillation or fractionation colunn
1
1
I
bottoms frcm the production of
1
1
I
chloro benzenes
1
1
I
(a) Benzene
711321
1
1000
100
AQTX.CARC I
(b) Dichlorobenzenes
1
1
I
(1) 1,2-isomer
955011.
1
100
100
311 I
(2) 1,3-isomer
5117311
1
100
AQTX I
(3) 1,1-isomer
1061671
1
100
100
311 1
(c) Trlchlorobenzenes
1
1
1
(1) 1,2,1-isomer
1208211
1
100
AQTX I
(d) Tetrachlorobenzene
1
1
1
(1) 1,2,t,5-isoroer
959131
1
5000
CTX 1
(e) Pentachlorobenzene
6089351
1
1000
CTX I
(f) Hexachlorobenzene
1187111
1
10
CARC I
(g) Benzyl chloride
1001171
1
1
1
100
10
CARC 1
1
RQTBL/CARC0185A.DTB/CONDATA.HED/12-APR-85 12:16:01
-------
DATA FOR
THE NPRM HAZARDOUS SUBSTANCES - Continued
Hazardous Substance (Note 1)
CASRN
Aquatic
Toxicity
(Note 2)
Mamaallan Toxicity (Note 3)
Chronic
Toxicity/
Carcinogen
(Note
Ignitability/
Reactivity
(Note 5)
311
RQ
(Note 6)
Proposed
RQ
(Note 7)
Basis for
Proposed RQ
(Note 8)
Comments
K086
Solvent washes and sludges, caustic
washes and sludges, or water washes and
sludges from cleaning tubs and
equipment used in the formulation of
ink from pigments, driers, soaps, and
stabilizers containing chromium and lead
(a) Lead (compounds)
(b) Hexavalent chromlun compounds
K095
Distillation bottoms from the
production of 1,1,1-trichloroethane
(a) 1,1,2-Trichloroethane
(b) 1,1,1,2-Tetrachloroethane
(c) 1,1,2,2-Tetrachloroethane
K096
Heavy ends from the heavy ends column
from the production of 1,1,1-
trichloroethane
(a) 1,2-Dichloroethane
(b) 1,1,1-Trichloroethane
(c) 1,1,2-Trichloroethane
K097
Vacuum stripper discharge from the
chlordane chlorinator in the production
of chlordane
(a) Chlordane
(b) Heptachlor
K098
Untreated process wastewater from the
production of toxaphene
(a) Toxaphene
K099
Untreated wastewater from the
production of 2,1,-D
(a) 2,4-Dichlorophenol
(b) 2,^,6-Trichlorophenol
N.A.
N.A.
79005
630206
793t5
107062
71556
79005
57719
76UU8-
8001352
120832
88062
5000
10
100
10
10
100
10
100
100
100
1000
100
10
1
10
100
10
Components
CTX
CARC
Component
CARC
CARC
AQTX,CARC
Components
CARC
AQTX ,CTX
CARC
Components
311
311
Component
3"
Component
AQTX
311
R
-------
DATA FOR THE NPRM HAZARPOUS SUBSTANCES - Continued
I Chronic
Aquatic
| Tojdcity/
Ignitablllty/
311
Proposed
Basis for
Toxicl ty
ICarclnogen
Reactivity
RQ
RQ
Proposed RQ
Hazardous Substance (Note 1)
CASRN
(Note 2)
Mammalian Toxicity (Note 3) 1 (Note 1)
(Note 5)
Note 6)
(Note 7)
(Note 8)
Comments
K100
— i ¦ a- ¦ ¦ ¦ ¦—
1
10
Components
Waste leaching solution from acid
1
leaching of emission control
1
dust/sludge from secondary lead
1
smelting
1
SEE K069
(Components of this waste are identical
1
10
Components
with those of K069)
1
1
K101
1
1
1
Components
Distillation tar residues from the
1
distillation of aniline-based compounds
1
in the production of veterinary
1
pharmaceuticals from arsenic or organo-
1
arsenic can pounds
1
(a) Arsenic (compounds)
N.A.
)
1
1
CARC
K102
1
1
1
Components
Residue from the use of activated
1
carbon for decolorization in the
1
production of veterinary
1
pharmaceuticals from arsenic or organo-
1
arsenic compounds
1
(a) Arsenic (compounds)
N.A.
1
1
1
CARC
K101
1
1
100
Components
Combined wastewater streams generated
1
from nitrobenzene/aniline chlorobenzenes
1
(a) Benzene
71132
1
1000
100
AOTX,CARC
(b) Aniline
62533
1
1000
5000
HHP
Note 19
(c) Diphenylamlne
12239*4
1
5000
T(orl)
Note 13
(d) Nitrobenzene
98953
1
1000
1000
311
(e) Phenylenediamlne (para-lsomer)
106503
1
1
100
AOTX
Note 11
K105
1
1
10
Component
Separated aqueous stream from the
1
reactor product washing step in the
1
production of chlorobenzenes
1
(a) Benzene
71132
1
1000
100
AOTX,CARC
(b) Honochlorobenzene
108907
1
100
100
311
(c) Dlchlorobenzene(s)
1
(1) 1,2-isooier
95501
1
100
100
311
(2) 1,3-isooer
541731
1
100
AOTX
(31 1,1~isoaer
106167
1
100
100
311
(di 2,1,6-Tnchlorophenol
880602
1
i |
10
10
311
RQTBL/CARC0185A .DTB/COMDATA-HED/12-APR-85 12:16:01
-------
NOTES FOR TABLE 3-1
DATA FOR THE NPRM HAZARDOUS SUBSTANCES
NOTE 1: The hazardous substances which appear on this list also appear in
Tables 7-1, 8-1, and 8-2 of the document titled, "Technical Background
Document to Support Rulemaking Pursuant to CERCLA Section 102, Volume 1,"
March 1985. The statutory sources for the listing of these hazardous
substances as CERCLA Section 101(14) hazardous substances may also be
found in those tables. The statutory sources are the CWA Section 311
(b)(4) (40 CFR 117), the CWA Section 307(a), and the CAA Section 112
(proposed 40 CFR 61), and those defined in the RCRA regulations
(40 CFR 261). Each entry is followed by the Chemical Abstract Services
Registry Number (CASRN).
NOTE 2: Aquatic Toxicity, unless specifically noted otherwise, is given as the
TL 96 (The 96-Hour Median Threshold Limit) for aquatic species. TLm96 is
that concentration of the material dissolved in water, in parts per
million (ppm) or milligrams/liter (mg/1) (which is equivalent) that will
kill 50% of the test organism population in 96 hours. Each TLm96 entry is
followed by a letter indicating the RQ to which it corresponds, on the
following scale:
TLJ^
<0.1
0.1-1
1-10
10-100
100-500
RQ (Pounds)
X (1)
A (10)
B (100)
C (1000)
D (5000)
Note that TL and the lethal concentration which will kill 50% of the test
population (E?C^q) are identical, as long as the time period is the same.
Aquatic toxicity data are taken from the following sources:
A. The reportable quantities assigned under the CWA Section 311, as given
in 40 CFR 117.3 (44 FR 50766-50779, August 29, 1979). The detailed
listing of aquatic toxicities that form the basis for these
assignments is found in report No. EPA 440/9-75/009, "Supplement to
Development Document: Hazardous Substances Regulations, Section 311
of the Federal Water Pollution Control Act as Amended 1972," November
1975 (PB 258514).
B. "The Registry of the Toxic Effects of Chemical Substances," RTECS,
accessed as a machine-searchable data base via the Chemical
Information System (CIS). RTECS is available in hardcopy, the latest
being DHHS (NI0SH) Publication No. 83-107, "1981-1982 Registry of the
3-43
-------
Toxic Effects of Chemical Substances," Volumes 1, 2, and 3,
U.S. Department of Health and Human Services, Public Health Service,
Center for Disease Control, National Institute for Occupational Safety
and Health, June 1983.
RTECS draws its aquatic toxicity data from "Water Quality
Characteristics of Hazardous Materials," by Dr. Roy Hahn, Jr. and Paul
Jensen, Texas A&M University, College Station, TX, 77843, 1974.
C. Publication 2-A, "Water Quality Criteria," Second Edition, Jack Edward
McKee and Harold V. Wolf (Editors). State of California, The
Resources Agency of California, State Water Quality Control Board,
1963.
D. "Handbook of Environmental Data on Organic Chemicals," Karel
Verschueren, Van Nostrand Reinhold Company, New York, NY, copyright
1977 by Litton Educational Publishing, Inc.
E. The "Oil and Hazardous Materials Technical Assistance Data System"
(OHMTADS), accessed as a machine-searchable data base via the EPA/NIH
Chemical Information System (CIS).
F. The 1980 Ambient Water Quality Criteria Documents for 64 toxic
pollutants or pollutant categories, published pursuant to the CWA
Section 304(a)(1) (45 FR 79318).
G. "Aquatic Toxicity Testing as Fundament for a Spill Prevention
Program," M. W. Curtis, C. M. Curran, and C. H. Ward, reported in the
Proceedings of the 1980 National Conference on Control of Hazardous
Materials Spills. (May 13-15, 1980, Louisville, Kentucky).
H. "Handbook of Acute Toxicity of Chemicals to Fish and Aquatic
Invertebrates," W.W. Johnson and M.T. Finley, United States Department
of the Interior Publication No. 137, 1980.
I. "Acute Toxicity of Priority Pollutants to Bluegill," R.J. Buccafusco,
et. al., Bulletin of Environ. Contam. Toxicol., V.26, pp.446-452,
1981.
NOTE 3: Three types of mammalian toxicity are entered in this column,
depending on the route of administration: oral, dermal (skin absorption)
or inhalation. The details of the entries are as follows:
A. Oral Toxicity: Unless otherwise identified, entries are those showing
the acute oral Lethal Dose to 50% of the test animal population (LD^q)
in milligrams per kilogram of body weight (mg/kg). Test species are
coded using the RTECS convention, as follows:
Hmn = human
3-44
-------
Rat = rat
Mus = mouse
Gpg = guinea pig
Dog = dog
Rbt = rabbit
Thus the entry "Rat-orl:60" indicates an oral of 60 mg/kg for
rats.
B. Dermal Toxicity; These entries are indicated by the abbreviation
"skn" immediately following the species code, and are again given as
the acute LD,.q in milligrams per kilogram of body weight (mg/kg).
Test species are coded the same as given under Oral Toxicity, above.
Thus the entry "Rat-skn:60" indicates dermal LD5q of 60 mg/kg for
rats.
C. Inhalation Toxicity: These entries are indicated by the abbreviation
"ihl" immediately following the species code. Data are presented in
terms of the concentration in air lethal to 50% of the test animal
population in parts per million (ppm) (LC,-0). The exposure time is
also given (H = hours, M = minutes), when available. Test species are
coded the same as given under Oral Toxicity, above. Thus the entry
"Rat-ihl:60/4H" indicates an inhalation of 60 ppm for 4 hours for
rats.
D. Low Lethal Dose or Low Lethal Concentration: These are shown by the
terms "LD '' or "LC^0". ^D. an<* ^lo are t^e ^owest doses or
concentrations known to have haa lethal effect on the test species.
Thus the entry Rat-ihl LC^q:60/4H indicates an inhalation of 60
ppm for 4 hours for rats.
Note: Human LC^ and LD. data are not used, since they generally
represent isolated accidental poisoning incidents. Toxicity data,
unless specifically noted otherwise, have been obtained from RTECS
(see Note 2B, above).
Each toxicity entry is followed by a letter indicating the RQ to which
it corresponds, on the following scales:
Oral LD
or LD-
lo
Dermal LD^q
or LD1q
Inhalation LC50
or LD1q
RQ (Pounds)
<0.1
<0.04
<0.4
X (1)
0.1-1
0.04-0.4
0.4-4
A (10)
1-10
0.4-4
4-40
B (100)
10-100
4-40
40-400
C (1000)
100-500
40-200
400-2000
D (5000)
3-45
-------
NOTE 4: Entries in this column are several and include the following:
A. The results of evaluations of chronic toxicity effects carried out by
EPA's ECAO. For chronic toxicity, the entries are given as a
numerical score, followed by an equivalent RQ designation, as follows:
Chronic Toxicity Score
81 to 100
41 to 80
21 to 40
6 to 20
1 to 5
RQ (Pounds)
X (1)
A (10)
B (100)
C (1000)
D (5000)
The scores are based on a combination of values assigned to minimum
effective doses and severity of the toxic effects, as described in
more detail in the report "Technical Background Document to Support
Rulemaking Pursuant to CERCLA Section 102, Volume 1," March 1985. An
"I.D." appears in this column to indicate where the data were
insufficient to complete an evaluation of the chronic toxicity of a
substance.
B. The results of evaluations of potential carcinogenicity carried out by
EPA's CAG. The CAG's methodology ranks a substance's relative
carcinogenicity as "high," "medium," or "low." RQ levels have been
assigned to these three relative rankings as follows:
RQ Category RQ (Pounds) Hazard Rank
X
1
High
A
10
Medium
B
100
Low
C
1000
—
D
5000
—
NOTE 5: Entries in this column include the following:
A. Ignitability: This is judged on combinations of flash point and
boiling point. These are entered in the column as F = flash point,
and B = boiling point, with the value immediately following in degrees
Fahrenheit. Materials that are capable of starting fires without an
external source of ignition are considered to be the most hazardous,
and are coded as follows:
PYR = Pyrophoric
SP0NT. IGN = Capable of spontaneous ignition
STRONG 0XID. = Strong oxidizer, may cause other materials to ignite,
3-46
-------
and sustain their combustion.
The entry "Solid" indicates that the material is solid at room
temperature and not readily ignitable.
B. Reactivity: Reactivity refers to either a material's reaction with
water, compared with certain reference materials (see scale given
below) or to its ability to undergo self-reaction, with explosion
being the worst case. Certain other types of reactivity, such as the
ability to liberate toxic gases, are discussed as individual cases in
separate notes.
Each ignitability or reactivity entry is followed by a letter indicating
the RQ to which it corresponds, based on the following scales:
REACTIVITY
Ignitability
Starts fires
F
B
F
B
<100
<100
<100
>100
100-140
With Water
(Reference
Compound)
Inflames
Extreme reaction
(e.g.,SO
High reaction
(e.g., oleum)
Moderate reaction
(e.g.,NHj)
Self-Reaction
Explosive
May polymerize;
requires stabilizer
May polymerize if
contaminated. No
stabilizer required.
Some chance of
polymerization with
small heat release
RQ (Pounds)
A (10)
B (100)
C (1000)
D (5000)
Data for ignitability and reactivity ratings were taken from "Fire
Protection Guide on Hazardous Materials," 7th Edition, National Fire
Protection Association, Boston, MA., 1978.
NOTE 6: Entries under this column show the value in pounds that was assigned
as an RQ under the CWA Section 311 (40 CFR 117.3, 44 FR 10279-10283,
February 16, 1979).
NOTE 7: Entries In this column are the lowest RQs derived from the individual
rankings shown under the Aquatic Toxicity, Mammalian Toxicity, Potential
Carcinogenicity, Chronic Toxicity and/or Ignitability/Reactivity columns.
NOTE 8: Entries in this column show the basis on which an RQ has been proposed
coded as follows:
3-47
-------
311 - The RQ was established on the basis of
aquatic toxicity under the regulations from the
CWA Section 311.
AQTX - Aquatic toxicity (other than a CWA Section 311
assignment).
T(orl) - Mammalian toxicity (oral)
T(ihl) - Mammalian toxicity (inhalation)
T(skn) - Mammalian toxicity (dermal)
CARC - Potential carcinogenicity
CTX - Chronic toxicity
1 - Ignitablity
R - Reactivity
CS - The RQ was assigned on the basis of chemical similarity
to another hazardous substance, in the absence of data
for the primary criteria.
Max - This entry indicates that the rating factors all exceed
the upper limit of the rating scales, and that the
assignment of a 5000-pound RQ has been made on the basis
of this being the largest value possible to assign.
BHP - Biodegradation, hydrolysis, or photolysis
NOTE 9: Polymerization may occur spontaneously in the absence of oxygen or on
exposure to visible light or excessive heat, violently in the presence of
alkali. Pure acrylonitrile is subject to self-polymerization with rapid
pressure development. The commercial product requires an inhibitor.
NOTE 10: Evidence found in OHMTADS and/or "Water-Related Environmental Fate of
129 Priority Pollutants" (EPA-440/4-79-029a) indicates that this material,
or a constituent of this material, is bioaccumulated to toxic levels in
the tissue of aquatic and marine organisms, and has the potential to
concentrate in the food chain.
NOTE 11: An RQ level of Category X (1 pound) is proposed for each of the
individual Aroclor compounds, based on the aquatic toxicity listed for the
broad class of PCBs.
NOTE 12: There are two arsenic acids, one identified by the CASRN 7778-39-4,
and having synonyms as arsenic acid (H^sO^), arsenic acid solution,
3-48
-------
arsenic acid liquid, and orthoarsenic acid. The other, with
CASRN 1327-52-2, has the synonyms arsenic acid liquid and arsenic
anhydride. Data on the latter may be found in OHMTADS, while the toxicity
of the former may be found in RTECS.
NOTE 13: Arsenic trichloride reacts vigorously with water to generate hydrogen
chloride.
NOTE 14: A carcinogenic potency factor estimate for asbestos is inappropriate
here because the carcinogenic potential of asbestos is related to specific
fiber shapes, sizes, and atmospheric concentrations. The concentration of
asbestos in air is usually expressed as either a number of fibers or a
mass of asbestos per unit volume of air. However, no general relationship
exists between the number of fibers and their mass; it depends on the
type of asbestos and the size of the fibers. Hence, the usual
dose-response relationship is difficult to derive for asbestos. As a
result, asbestos has been tentatively assigned an RQ of 10 pounds for
carcinogenicity, on an administrative basis.
NOTE 15: Carcinogen hazard ranking will be possible when methodology to
calculate a reasonable potency factor is developed or new data becomes
available. At present, there is either sufficient or limited data that
shows these substances to have a carcinogenic effect, but not enough
quantitative information about the associated doses to allow a potency
factor to be estimated. An administrative RQ assignment of 10 pounds has
been recommended for these substances, with one exception. The substance
2,6-dinitrotoluene is recommended for a 100-pound RQ because the CAG
methodology resulted in a direct 100-pound assignment (low ranking) for
the isomeric 2,4-dinitrotoluene.
NOTE 16: Benzyl chloride, if unstablized, readily undergoes a condensation
reaction with liberation of heat and hydrogen chloride in the presence of
copper, aluminum, iron, zinc, magnesium, tin, and various other metals
that act as catalysts. If the reaction takes place in a container, there
is the possibility of violent rupture of the container.
NOTE 17: Beryllium chloride reacts vigorously with water with the evolution of
heat, forming beryllium oxide and hydrochloric acid solution.
NOTE 18: An RQ of 1 pound was established for the gamma isomer of hexachloro-
cyclohexane, commonly known as Lindane, under the CWA Section 311. An RQ
of 1 pound is proposed for all isomers of Hexachlorocyclohexane, based on
similar chemical structures, since detailed data are not available in all
cases.
NOTE 19: The proposed RQ takes into consideration one or more of the natural
degradation processes of biodegradation, hydrolysis, or photoloysis (BHP).
More specifically, the lowest RQ supported by any of the primary criteria
has been adjusted upward one level. Specific BHP data may be found in
Appendix A.
3-49
-------
NOTE 20: Degradation of this substance could lead to the formation of
trivalent inorganic arsenic compounds, which have been identified as
carcinogens in the "First Annual Report on Carcinogens."
NOTE 21: Chloral rapidly hydrates upon ingestion to form chloral hydrate. The
toxicity value shown is that of the hydrate.
NOTE 22: The suggested RQ level of Category A (10 pounds) is based on the fact
that this material is a strong oxidizer and can readily cause fires.
NOTE 23: On September 18, 1984 the Agency announced its decision (49 FR 36560)
to list Coke Oven Emissions as a hazardous air pollutant under Section 112
of the Clean Air Act. Emission standards remain to be proposed. As part
of EPA's efforts to determine whether to regulate Coke Oven Emissions
under Section 112, EPA prepared several documents relevant to this
decision. In the final document entitled "Carcinogen Assessment of Coke
Oven Emissions," EPA-600/6-82-003F, February 1984, a number of potentially
carcinogenic substances are identified as constituents of Coke Oven
Emissions, including polycyclic organic matter (POM) (e.g.,
benzo(a)pyrene, benzo(b)fluoranthene, benzo(j)fluoranthene,
benzo(b)anthracene, and chrysene), aromatic compounds (e.g.,
beta-naphthylamine, benzene), and trace metals (e.g., arsenic, beryllium,
cadmium, chromium, nickel) which are of concern due to their potential
carcinogenic effects. Extensive epidemiological studies of coke oven
workers have shown them to be at an excess risk of mortality from lung
cancer, prostate cancer, and kidney cancer. The Carcinogen Assessment
Document concludes that Coke Oven Emissions are carcinogenic to humans,
and the Science Advisory Board (SAB) unanimously concurred with this
conclusion.
The proposed RQ of one pound shown for Coke Oven Emissions is based upon
the "high" CAG ranking for a common constituent of coke oven emissions,
benzo(a)pyrene, which has produced cancer in a number of organs of nine
animal species by various routes of administration.
NOTE 24: Coal tar cresote is identified by the CASRN 8001-58-9, and data
presented is for this material. No data were found that would allow
rating of beechwood creosote, CASRN 8021-39-4.
NOTE 25: The proposed RQ listed for 3,3'-Dichlorobenzidine is based on the RQ
for benzidine, since benzidine is a hazardous degradation product of
3,3 '-Dichlorobenzidine.
NOTE 26: This material requires an inhibitor to prevent polymerization.
NOTE 27: No specific data were found for diethylarsine. However, the alkyl
arsines, as a class, are pyrophoric, and diethylarsine has been placed at
a suggested RQ level of A (10 pounds) on this basis. (See also Note 20.)
3-50
-------
NOTE 28: The potential carcinogenic hazard ranking shown for unspecified
dinitrotoluene and 3,4-dinitrotoluene (Low 100) is based on analogy to the
carcinogenic ranking determined for 2,4-dinitrotoluene.
NOTE 29: A 100-pound RQ is being proposed for 2,6-dinitrotoluene based on its
chemical similarity to 2,4-dinitrotoluene.
NOTE 30: Common name for this material is Hydrazobenzene.
NOTE 31: An RQ of 1 pound is suggested for this material based on the 1-pound
RQ assigned to Heptachlor under the CWA Section 311.
NOTE 32: The RQ for methyl isocyanate is being re-proposed on the basis of an
administrative decision by the Agency.
NOTE 33: All cyanides assigned RQs under the CWA Section 311 (40 CFR 117.3,
44 FR 10279-10283, February 16, 1979) were placed at RQ level A
(10 pounds) on the basis of the aquatic toxicity of the cyanide ion. The
same practice is continued here.
NOTE 34: The Agency will adjust the RQ for radionuclides in a future
rulemaking.
NOTE 35: The carcinogenic hazard ranking shown for unspecified trichlorophenol
is based on the ranking shown for the specific isomer
2,4,6-trichlorophenol.
NOTE 36: Vinyl chloride polymerizes in presence of air, sunlight, or heat
unless stabilized by inhibitors.
NOTE 37: A maximum RQ (5000 pounds) is suggested for
1,1,2-Trichloro-l,2,2-tri- fluoroethane on the basis of the following
data:
Rat = 43,000 mg/kg (oral)
LC50 Rat = 87,000 ppm/6 hours (inhalation)
NOTE 38: An RQ level of D (5000 pounds) is proposed for 1,2,3-Trichloropropane
on the basis of the following data:
LD50 Rat = 320 mg/kg (oral)
LC50 Rat = 1000 ppm/4 hours (inhalation)
NOTE 39: An RQ level of C (1000 pounds) is suggested for 2,3-Dichloro-n-pro-
panol on the basis of the following data:
LD5q Rat = 90 mg/kg (oral)
LCio Rat = 500 ppm/4 hours (ihl)
NOTE 40: This is an aqueous waste, and it has been assumed that the antimony
3-51
-------
compound in solution is the trichloride.
NOTE 41: The proposed RQ for Tars (polycyclic aromatic) is based on the lowest
RQ assigned to specific polycyclic aromatics (i.e., benzo(a)pyrene) on the
basis of potential carcinogenicity.
NOTE 42: These esters are assumed to be composed of Phorate and/or its
analogues, and accordingly an RQ level will be suggested, based on the RQ
assignment of Phorate Itself.
NOTE 43: An RQ level of D (5000 pounds) is suggested for Diphenylamine on the
basis of the following data:
LD50 gPS = 300 mg/kg (oral)
NOTE 44: An RQ level of B (100 pounds) is suggested for paraphenylenediamine
on the basis of the following data:
TLm(48) Goldfish = 5.7 ppm
LD50 Rat « 80 mg/kg (oral)
NOTE 45: An RQ level of C (1000 pounds) is proposed for 2-Chloro-l,3-butadiene
(Chloroprene) on the basis of the following data:
AQTX (TL 96) = 10 - 100 ppm
Flash Po?nt = -4°F
Boiling Point = 139°F
NOTE 46: New data in the "Handbook of Acute Toxicity of Chemicals to Fish and
Aquatic Invertebrates," USDOI Publication No. 137, indicates that the
aquatic toxicity of parathion results in an RQ of ten pounds for aquatic
toxicity, versus older data used to assign a 1-pound RQ under the CWA.
3-52
-------
Appendix A
DATA FOR EVALUATIONS OF BIODEGRADATION,
HYDROLYSIS, & PHOTOLYSIS (BHP)
A-l
-------
APPENDIX *
DATA FOR EVALUATION OP BIODEGRADATION, HYDROLYSIS A PHOTOLYSIS (BHP)
Hazardous Substance
CAS No.| B
Data / Comments
2-AcetyVamlnofluorene
Aoryionltrlle
53963
107131
Aldrln
309002
Aoltrole
Ammonium bichromate
61825
7789095
Ho data
Aoryionltrlle Is subject to blodegradatlon (Kuchlnskll, et al. 1977; Panova, et al. 1977!
Anon, 1977| Sohnee, et al. 1977* Kato and Yamamura, 1976} Mlkaml, et al. 1971).
Measurement of biochemical oxygen demand has shown 25 to 70S degradation Mlthln 10 days (Hann
and Jensen, 1970).
Blodegradatlon of aoryionltrlle Is reported to oocur readily at concentrations less than 20
mg/l under anaeroblo conditions. Acollmated sludge oan degrade 35* of the pollutant at
concentration levels of 500 mg/l. (Ref.1)
Blodegradatlon by mutant microorganisms:500 mg/i 6 20°c
t disruption! pa rent 1 84* In 24 hour
mutanti 100* In 4.0 hour. (Ref.2)
BOD .. = 25J removal t 20°C with 1 year acollmated sewage aeedj feed cono. = 100-1000
mg/l.
BODj
BOD * a 60< ThOD, 100* removed 6 20°C with 30+ day aoollmated seed| feed cono. = 40 mg/l
BOD "
Dj_Iq s 67* removed i 20°C with 27 day aoollmated seed| feed oono. = 50 mg/l.
o 60* ThOD, 100$ removed 6 20°C with 8 day acollmated seed| feed cono. = 10 mg/l
28
s 70+* ThOD, 95«f removed 0 22-25°C with 21 day aoollmated seed| feed oono. 89
mg/l. (Ref.6)
Blolopln*; ei,ei.i
putlda) lRef.2)
¦nnihirion of baote"'» "til -uittpllo-tlon starts at 53 mg/l (Pseudomonas
Hydrolysis Is not environmentally significant (Ref.1 )
Dlreot photolysis la Improbable in aquatlo environments. (Ref.1 )
Photo-oxldntlon In the troposphere j a major fata prooeas (half-life "4 hours). (Ref.1)
Volatilization Is the most likely major transport process. (Ref.1 )
There does appear to be biological transformation of aldrln to dleldrln. - (Ref.1)
Hydrolysis Is not an Important process (Half-life >4 years). (Ref.1)
Dlreot photolysis la slow. Indirect photolysis may be Important (one expt., half-life s 1 day)
(Ref. 1)
Volatilization of aldrln from aquatlo systema Is an Important process, with half-lives on the
order of a few hours to a feu days. (Ref.1)
Bloocumulatlon is an Important process. The results of terrestrial-aquatic mlorocosm
experiments Indicate that bloconcentratlon faotors for aldrln In aquatlo systems will be
approximately lO^-lO1*. (Ref.1)
Amltrole Is resistant to hydrolysis and the action of oxidizing agents. (Ref.4)
Inorganlo.
Can bloconcentrate (ohromate) - (Ref.3)
RQTBL/bhpnotea.ftb/cnotes.heJ/10-HAY-84 08:21103
-------
Hazardous Substance
DATA FOR EVALUATION
CAS No.I B I H
OP BIODEQRADATION, HYDROLYSIS & PHOTOLYSIS (BHP) , Continued
P I Data / Comments
Ammonium chromate
Aroolor 1016
Aroolor 1221
Aroclor 1232
Aroclor 12M2
Aroolor 1218
7788989
12671112
11104282
11111165
53169219
12672296
Inorganlo.
Can blooonoentrata (ohromate) - (ftef.3)
Available evldenoe lndloates that polyohlorlnated blphenyls, especially those with four or
more chlorine atoms per moleoule, are persistent In the environment. (Ref.1)
PCBs are strongly resistant to both aoldlo and baslo hydrolysis. (Ref.1)
There la experimental evidence that the heavier PCBs (five chlorines, or more per moleoule)
oan be photolyzed by ultraviolet light, but there are no data to Indicate that this prooess Is
operative In the environment. (Hef.1)
Available evidence Indicates that polyohlorlnated blphenyls, especially those with four or
more ohlorlne atoms per molecule, are persistent In the environment. (Ref.1)
PCBs are strongly resistant to both aoldlo and baslo hydrolysis. (Ref.1)
There Is experimental evldenoe that the heavier PCBs (five ohlorlnes, or more per molecule)
oan be photoly2^ad by ultraviolet light, but there are no data to indicate that this process la
operative In the environment. (Ref.1)
Available evldenoe lndloates that polyohlorlnated blphenyls, especially those with four or
more chlorine atoms per molecule, are persistent In the environment. (Ref.1)
PCBs are strongly resistant to both aoldlo and baslo hydrolysis. (Ref.1)
There is experimental evidence that the heavier PCBs (five chlorines, or more per moleoule)
can be photolyzed by ultraviolet light, but there are no data to indlaate that this prooess Is
operative In the environment. (Ref.1)
Available evidence lndloates that polyohlorlnated blphenyls, especially those with four or
more ohlorlne atoms per molecule, are persistent in the environment. (Ref.1)
PCBs are strongly resistant to both aoldlo and baslo hydrolysis. (Ref.1)
There Is experimental evldenoe that the heavier PCBs (five ohlorlnes, or more per molecule)
oan be photolyzed by ultraviolet light, but there are no data to Indicate that this process Is
operative In the environment. (Ref.1)
Available evidence lndloates that polyohlorlnated blphenyls, espeolally those with four or
more ohlorlne atoms per moleoule, are persistent In the environment. (Rer.1)
PCBs are strongly resistant to both aoldlo and baslo hydrolysis. (Ref.1)
There Is experimental evldenoe that the heavier PCBs (five ohlorlnes, or more per molecule)
can be photolyzed by ultraviolet light, but there are no data to Indicate that this process Is
operative In the environment. (Ref.1)
RQTBL/bhpnotes.ftb/cnotes .hed/10-MAT-81 08i21i03
-------
DATA FOR EVALUATION QP BIQDBGRADATION, HTDRQLYSI3 4 PHOTOLYSIS (BHP) - Continued
Hazardous Substance
1 CAS No.| D 1 H
P I Data / Comments
Aroclor 1251
1 I 1
1110976911 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
I Available evidence Indloates that polychlorlnated blphenyl3, espeolally those with four or
I more chlorine atoms per molecule, are persistent In the environment. (Ref.l)
1
1 PCBs are strongly resistant to both aoldlo and baslo hydrolysis. {Ref.l)
1
1 There la experimental evldenoe that the heavier PCBs (five chlorines, or more per molecule)
1 can be photolyzed by ultraviolet light, but there are no data to lndloate that this process la
1 operative In the environment. (Ref.l)
|
Aroclor 1260
1 II
1110968251 1
1 1 1
1 i 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
I I 1
1
1 Available evldenoe Indloates that pol/chlorinated blphenyls, espeolally those with four or
I more chlorine atana per moleoule, are persistent In the environment. (Ref.l)
1
1 PCBs are strongly resistant to both aoldlo and baslo hydrolysis. (Ref.l)
1
1 There is experimental evldenoe that the heavier PCBs (five chlorines, or more per molecule)
I can be photolyzed by ultraviolet light, but there arq^no data to lndloate that this process la
1 operative In the environment. (Ref.l)
1
Arsenlo
1 II
1 71M0J82I |
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
1 Arsenlo la metabolised by a number of organisms to organoaraenloals, thereby Increasing
1 arsenlo aoblllty In the environment. (Ref.l)
1
1 Photolysis la not an Important process. (Ref.1)
I
I Bloaooumulatlon appears to be moat significant in lower trophlo levels. (Ref.l)
1
Arsenic acid
1 13275221 1
t 7778391J I
1 1 1
1
1 Inorganic,
1
1
Arsenlo disulfide
1 13033281 I
1 1 1
1
1 Inorganic*
1
Arsenlo pentoxlde
1 13032821 1
1 1 1
1
1 Inorganic*
1
Arsenlo trichloride
1 77813111 1
1 1 1
1
1 Inorganic*
1
Arsenlo trloxlde
1 13275331 1
1 1 1
1
t Inorganic.
1
Arsenic trlsulflda
1 13033391 1
1 1 1
1
1 Inorganlo.
1
Asbestos
1 13322111 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
1 "Asbestos Is atable... and is not prone to slgnlfloant chemical or biological degradation In
1 the aquatlo environment. After Introduction Into surface waters, asbestos remains
1 in suspension until physical degradation or chemical coagulation allows it to settle Into the
1 sediment layer. (Ref.1)
1
I Asbestos Is not affected by photolytlc processes. (Ref.1)
1
Auramine
1 1928081 1
1 1 1
1
I No data
1
Azaserlne
1 1 1
1 1150261 1
1 1 1
1
1 No data
1
Azlrldlne
1 1515611 I
1 1 1
1
1 Strong posslbllty of food chain concentration. - (Ref.3)
1
RQTBL/bhpnotes.ftb/cnotes.hed/10-MA1-81 08i21s03
-------
Hazardous Substance
Benz[cJaorldlne
Benz[a]anthracene
Benzene
Benzidine
BIQDEQRADATION, HYDROLYSIS % PHOTOLYSIS (BHP) - Continued
I Data / Commenta
Ho data
Ho data
Benzene oan be utilized aa the sole source of oarbon by several microorganisms and la probably
biodegradable at a alow rate. (Ref.1)
Helfgott et al. (1977) report the blorefraotory Index of benzene to be 0.23, Indicating that
benzene la quite resistant to degradation. (Ref.1).
BOD^ 3 2f ThOD 6 20°C with 14 day aoallmated seed. (Ref.6)
B0D1/2 a 33' ThOD 6 20°C with phenol aoallmated seed} feed cono. = 250 mg/1. - (Ref.6)
Wttj a Of ThOD with sewage seed|
BOD5 s |.9f ThOD with sewage seed|
BOD5 3 21$ ThOD with sewage seed;
BODc s 5BJ ThOD with aoalloated aewaga seed|
Fooa chain contamination potential-negative. (Ref.3)
I
BOD- = 10* ThODl
33f ThOD oxidation of 500 ppo of benzene by phenol aotlvated sludge after 12 hrs of aeration.
(Ref.2)
B0I>10 = 1.2 lb/lb.
Hydrolysis Is not a significant fate process. (Ref.1)
Photolysis Is unlikely slnoe the ozone layer In the upper atmosphere effeotlvely filters out
wavelengths of light leas than 290 no. Dlreot exaltation of benzene In the aquatla or
atmospherlo environment Is unlikely unless a substantial wavelength shift Is caused by the
media. (Ref.1)
Dlreot oxidation of benzene In environmental waters la unlikely. Smog ohamber data, however,
Indicate that benzene is photo-oxldlzed at a rapid rate In the atmosphere. (Ref.1)
f
Volatilization 1s the primary transport process. (Ref.1)
Blodegradatlon may contribute slightly to the degradation or benzidine during sewage plant
treatment. Ho specific information was fnund about environmental degradation. (Ref.1)
There are no data to suggest that hydrolysis of benzidine is an envlronmentlly significant
process. (Ref.1)
The capabllty of benzidine to absorb electromagnetic energy In the near ultraviolet region
makes photolysis a distinct possibility. Nonetheless, no Information was found demonstrating
that dlreot photolysis was an environmental fate. (Ref.1)
Lake water degradation experiments (precluding photolysis) suggest a half-life of 1 hours.
(Ref.3)
RQTBL/bhpnotes.ftb/cnotes.hod/10-HAY-81 08121t 03
-------
DATA FOR EVALUATION OF BIODEGRADATION, HYDROLYSIS & PHOTOLYSIS (BHP) - Continued
Hazardous Substance
1 CAS No.| B 1 H
P I Data / Comments
Benzo[b]fluoranthene
1 1 1
1 2059921 1
1 1 1
1 1 1
1 1 1
1
1 The dissolved portion may undergo rapid photolysis. Ho speolflo data were found however and
I the reaotlon produots are qulnones; no hydrolysis; long time required for blodegradatlon. -
I (Ref.1)
I
Benzo(k)fluoranthene
1 II
1 2070891 1
1 1 1
1 1 1
1 1 1
1
I The dissolved portion may undergo rapid photolysis. Ho speolflo data were found however and
I the reaotlon produots are qulnonesi no hydrolyslsi long time required for blodegradatlon. -
1 (Ref.1)
i
Benzo[a]pyrene
1 II
1 503281 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
1 PhotodecomposltJ.on produots are qulnones.
I
1 Photolysis half-life = 3 hours In stream, 1.5 hours In olear lake (unspecified produots);
I Photolysis of benzo[a]pyrene yields a mixture of three qulnones;
1 Hydrolysls/blodegradatlon not Important. (Rer.1)
1
Benzotrlohlorlde
1 980771 1
I I 1
1
1 No fate and effeots data available*
1
Benzyl ahlorlde
1 11
I 100*1*171 |
1 1 1
i
I No data
1
Beryllium
I ii
1 7M10117I 1
1 1 |
I
I Inorganlo
1
Beryllium chloride
1 7787*751 1
1 1 1
i
1 Inorganlo
1
Beryllium fluoride
i ii
1 77871971 1
1 1 1
i
1 Inorganlo
I
Beryllium nitrate
i ii
H359799MI 1
1 1 1
i
1 Inorganlo
i
alpha - BHC
1 3198
-------
DAT* FOR EVALUATION OF BIODEQHADATION, HYDROLYSIS ft PHOTOLYSIS (BHP) - Continued
Hazardous Substance
I CAS Ho.I B I H
P 1 Data ! Comments
Bla (2-chloroethyl) ether
I I I
1 111(4441 |
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
1 Ho Information was Pound from whloh any oonoluslon regarding blodegradatlon oan be reached
1 with any degree of confidence. Blodegradatlon may be Important In acollmated settling ponda.
1 (Ref. 1)
1
1 Hydrolysis of the oarbon-chlorlne bonds Is a slow but perhaps significant process. (Half-life
1 "0.5-2 years.) (Ref.1)
1 Dlreot photolysis Is probably not Important. (Ref.1)
1
1 Potential ror accumulation. (Ref.3)
I
Bls(chloroaethyl) ether
1 5128811 | X
1 1 1
1 1 1
1 1 1
1 1 1
1
1 Blodegradatlon Is not likely. (Ref.1)
1 Rapid hydrolyslst half-life = 10-40 seo. (Rer.1)
1 The expected degradation produots are formaldehyde and HCl.
1 Photolysis probably does not ocour. (Ref.1)
i
Bla (2-ethylhexyl) phthalate
1 1178171 1
1 1 1
1
1 5000-pound HQ (maximum level) already assigned.
I
Cacodyllo aold
1 756051 1
i | a
i
1 No data
i
Cadmium
1 74404391 1
1 1 1
I
1 Inorganto
i
Cadmium acetate
1 5439081 I
i i i
•
1 Inorganlo
1
Cadmium bromide
1 77891261 |
1 | |
i
1 Inorganlo
Cadmium chloride
1101086421 1
1 1 1
1
1 Inorganlo
1
Calcium arsenate
1 77784411 |
i i i
i
1 No data
l
Calcium araenlte
I I I
1527401661 I
i i i
I
1 No data
t
Calcium chromate
1 II
1137651901 I
1 1 1
I
1 No data
I
Carbon tetrachloride
1 562351 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
i
1 Blodegradatlon probably ooaurs at an extremely slow rate. (Ref.1)
I Inhibition of baoterla cell multiplication starts at 30 mg/l. (Ref.2)
1
1 Hydrolysis is too slow to be a slgnlflaant fate process^ the minimum hydrolysis rate Is 7000
1 years. (Ref.1)
1
1 Photolysis Is probably not significant In aquatlo systems. Photolysis In the stratosphere Is
I the primary Tate of this compound. (Ref.1)
1
1 Volatilization Is the primary transport prooess from the aquatlo environment. (Ref.1)
1
1 Some evidence of bloaooumulatlon. (Ref.3)
1
Chloral
1 758761 I
1 1 1
1 Inhibition of baoterla oell multiplication atarta at 1.6 rag/I. - (Ref.2)
I
Chlorambucil
1 3050331 1
1 1 1
i
1 No data
i
RQTBL/bhpnotea .ftb/cnotes .hed/ 10-MM-84 08i 21«03
-------
DATA FOR EVALUATION OF BIODEQRADATION, HYDROLYSIS & PHOTOLYSIS (HHP) - Continued
Hazardous Substance
1 CAS No.1 B 1 H
P I Data / Comments
Chlordane
1 1 1
1 577*191 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
i
1 Although blodegradatlon of ohlordane la very alow, It may be an Important process Tor
1 ultimate degradation. (Ref.1)
1
1 Hydrolysis Is not an Important proceas (half-life >4 years). (Ref.t)
1
1 Photolysis probably requires a sensitizer. (Ref.1)
1
1 15t remained after 24 hours exposure to UV radiation (unspeolfled produots). - (Ref.5)
1
1 High potential for bloacounulatloni will contaminate food ohaln. (Ref.147)
1
1 Volatilization Is probably an important process. (Ref.1)
I
Chlornaphazlne
1 4910311 1
1 1 1
1
1 No data
j
Chloroform
1 676631 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 No speolflo Information was found on the blodegradatlon of chloroform. (Ref.1)
1 Little or no blodegradatlon In P0TW.
1 Subjeot to limited blodegradatlon. (Ref.3)
1 Hydrolysis la probably not a significant fate processi Half-life = 15 months — 3500 years.
1 (Ref.1)
1
1 Photolysis Is probably not significant in aquatlo systems. (Ref.1)
1
1 The primary fate of this compound Is attack by hydroxyl adlcals In the troposphere. (Ref.1)
1
1 Inhibition of bacteria cell multiplication starts at 125 mg/l. (Ref.2)
I
M-Chloro-o-toluldlne, hydrochloride
\ 31659331 1
1 1 1
1
1 No data
1
Chloromethyl methyl ether
i ii
1 1073021 I X
1 1 1
1 1 1
1
1 Chloromethyl methyl ether undergoes decomposition in water to form methanol, formaldehyde, and
1 hydrochloric aold.
I
Chromic acid
1111157151 1
1 1 1
1
1 Inorganlo
1
Chromium
I 7440*731 1
1 1 1
i
1 Inorganlo
1
Chrysene
i ii
1 2160191 1
1 1 1
i
1 No data
1
Creosote
I i I
I 60015891 1
i i i
i
1 No data
|
Cuprlc acetoaraenlte
1 1 1
1120020361 |
1 1 1
1
1 No data
¦
Cyclophosphamide
1 501601 1
1 1 1
l
1 No data
1
Daunooycln
i ii
1208308131 |
1 1 1
i
1 No data
1
RQTBL/bhpnotes.ftb/cnotes .tied/ 10-HAY-84 08: 21103
-------
DATA PGR EVALUATION OF BIODEORADATION, HYDR0LY3I3 & PHOTOLYSIS (BHP) - Continued
Hazardous Substance
1 CAS No. I B | H
P 1 Data / Comments
DDD
1 1 1
1 725181 |
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
1 Blodegradatton very alow. (Her.1)
1
1 Hydrolysis Is not an important process; Half-life - 570 days 9 pH a 9, 190 years 8 pH = 5I
1 (Ref.1)
I
I Photolysis Is not an important prooeasi Half-life a >150 years In H^o. (Ref.1)
1 Persistent In water & sediments, will bloaceumulate. (Ref.1)
I
DDE
1 725591 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
1 Blodegradatton very slow. (Ref.1)
1
1 Hydrolysis la not an Important prooeasj Half-life a >120 years 8 pH = 5. (Ref.1)
1
I Photolysis oan be an Important prooess for DDE In water) Half-life for photolysis In H^O a 1
1 day In strong sunlight, 6 days In weak sunlights (Ref.1)
1
1 Bloaocuoulatlon la an Important prooesa. (Ref.1)
I
DDT
1 502931 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
1 DDT la chemically, and blologloally quite atable and Its degradation poses a serious
1 challenge. (Ref.tf)
1 Blodegradatton is not an important removal process. (Hef.1)
1 5*1* DDT remained after 24 hour exposure to 0V radiation (produots unspeolfled). (Ref.5)
1
1 Hydrolysis may be Important under oertaln conditions,
t Half-life for hydrolysis = ~ 12 yeara 6 pH <5|
1 Half-life for hydrolyala = " 81 daya 6 pH a 9;
1
1 Dlreot photolysis la alow| Indlreot photolysis may be Important.
1 Half-life for dlreot photolysis In H_c a >150 years (fqrms DDE);
1 Half-life for Indlreot photolysis ln'T^ -7 ,jaya (forma DDB);
j High potential for bloaoounulatlon. (Ref.1)
1
1 Volatilization Is an Important process. (Ref.1)
1
Dlallate
1 23031641 I
1 1 1
1 1 1
1 1 1
1 1 1
1
1 Dlallate Is an oily amber or brown liquid, almost Insoluble In water and denser than water.
1 Soil moisture dlsplaoe dlallate from Its woll adsorption sites and forces dlallate Into the
1 vapor phase. In alkaline medium, dlallate Is hydrolyzed.
1 Hydrolysis Is at the ester linkage and forms a mercaptan, C02, and an alkylamlne. (Ref.3)
2,4-Dlamlnotoluene
1 958071 1
1 1 1
1
1 No data
a
DlbenzCa,h]anthracene
1 1 1
1 537031 1
1 1 1
1
1 No data
1
Dlbenz[a,l]pyrene
1 1895591 1
1 1 1
1
1 No data
1
1,2-Dibromo-3-chloropropane
1 961281 |
1 1 1
l
1 No data
1
RQTBL/bhpnotea.ftb/cnotes.hed/10-MAY-84 08 j 21103
-------
Hazardous Substance
DATA FOR EVALUATION
CAS No.I B I H
OF BIODEORADATIOH, HYDROLYSIS & PHOTOLYSIS (BHP) - Continued
P I Data / Comments
3(3'-Dlohlopobenzldlne
919M1
1,2-Dlohloroethane
107062
1,1-Dlchloroethylene
Dlchlorophenylarslne
75351
696286
3,3'-Dlchlorobenzldlne does not appear to be degraded by aquatlo microorganisms, activated
sludge, fish or terrestrial mammals. (Ref.1)
Hydrolysis Is probably not Important. (Ref.1)
Photolysis probably makes a direct contribution to the aquatlo fate of 3,3'-dlchlorobenzldlne
and Its degradation products. Half-life for photolysis = " 90 seo. (Produots are 3-
ohlorobenzldlne, benzidine.) (Ref.1)
Oxidation by naturally ooourrlng metal oatlons nay contribute to the degradation of this
pollutant In sediments. (Ref.1)
Has the potential to bloaooumulate. Probably little hydrolysis or blodegradatlon. Substance
undergoes photolysis to produoe 3-Chlorobenzldlne. - (Ref.3)
There is evidence of metabolism of 1,2-dlohloroethane by fish and oysters. (Ref.1)
BOD1-10 s 15? removed §20°C with 305+ day acollmated sewage seed; feed cono. s 200 mg/l|
B0Dj_jq s 30$ removed 820°C ulth 3'5* day aoollmated sewage seed; feed cono. = 100 mg/l{
BOD. Q a 9J Removed C20°C with 365+ day acollmated seed| feed cono. 3 1000 mg/l.
(Rer"6j
BOD
0
OD, s 0t ThOD| BOD.g = 18> ThODj Subjeot to some blodegradatlon; Relatively stable to
hefflloal attaak In water. - (Ref.3)
BOD 3 7* of ThODt
Inhibition of baoterla cell multiplication starts at 135 mg/l. (Ref.2)
B0D5 n 0.002 lb/lb.
Hydrolysis probably occurs too slouly to be a significant fate prooess (half-life ~ 50,000
years). (Ref.1)
Photolysis appears to be Insignificant In the aquatlo environment. The slow photo-oxldatlon In
the atmosphere probably leaves some unreacted compound to diffuse upward above the ozone layer
to undergo photodlssoolatlon. (Ref.1)
Photo-oxldatlon In the troposphere appears to be the predominant fate of this compound. Photo-
oxldatlon In the aquatlo environment ooours at a slow rate. Direct oxidation at ambient
conditions does not ocour significantly In the aquatlo or atmospherlo environment. (Ref.1)
Volatilization Is the primary transport process. (Ref.1)
Little blodegradatlon In P0TU; Little photolysis or blodegradatlon; half-life for hydrolysis =
1 year. (Ref.1)
Ho fate and effects data available.
RQTBL/bhpnotes.ftb/cnotes.hed/10-HAY-BU 08:21t03
-------
DATA FOR EVALUATION OF BIODEQRADATION, HTOR0LY3I3 & PHOTOH3I3 (BHP) - Continued
Hazardous Substance
1 CAS No. I B I H
f 1 Data / Comments
Dleldrln
1 1 1
1 605711 1
1 1 I
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
1 Blodegradatlon Is not an Important removal process.
I Several authors olte dleldrln as being one of the more nonbiodegradable chlorinated
1 peatloldes. (Ref.1)
1
1 Hydrolysis is not an Important process; Half-life for hydrolysis = >1 years. (Ref.1)
I
I Direct photolysis may be Important} Half-life for photolysis in uater = 2 months (forms
I photodleldrln uhloh is toxlo). (Ref.1)
1
I Does bloacoumulate, will contaminate the food ohaln. (flef.3)
1
Dlethylarslne
1 II
I 6921221 I
1 1 1
1
| Spontaneously flammable
1
1,1-Dlethylene dioxide
1 1239111 I
1 1 1
i
1 Inhibition of bacteria oell multiplication starts at 2700 og/1. - (Ref.2)
N, N'-Diethylhydrazlne
i i i
1 16158011 I
1 1 1
1
I No data
i
Dlethylatllbestrol
1 565311 1
1 1 1
I
I No data
1
Dlhydrosafrole
1 915861 |
1 1 1
•
I No data f
I
3,3'-Dlmethoxybenzidine
1 1199011 X I
1 1 1
1 1 1
1 1 1
i
1 Degradation by aerobaotori 500 mg/l C 30°C. (Ref.2)
I % ring disruptions parenti 78> in 120 hr
I mutant* 100) In 36 hr
I
Dlmethylaminoazobenzene
1 601171 1
1 1 1
1
I No data
I
7,12-Dlmethylbenz[a]anthracene
1 579761 1
1 1 1
I
1 No data
1
3,3'-Dlmethylbenzidine
1 1199371 1
1 1 1
i
1 No data
1
Dlaethylcarbamoyl ohlorlde
1 791171 1
1 1 1
1
I No data
I
1,1-Dlmethylhydrazlne
1 571171 1
i a |
I
I No data
i
1,2-Dlmethylhydrazlne
1 5107381 I
1 l 1
1
I No data
i
Dimethyl sulfate
l 1 1
1 777811 I X
1 1 1
1 1 1
1 1 1
1 1 I
I
1 No BOD data available.
I Hydrolysea rapidly 6 l8°c or higher forming sulfurlo aold and methanol.(Ref.3)
1
I Will not oonoentrate In food chain. (Ref.3)
l
Dlnltrotoluene
3,1-Dlnltrotoluene
i 1 1
1253211461 |
1 6103991 1
1 1 1
i
I See data for 2,1- and 2,6- Isomers below.
1
1
RQTBL/bhpnotea.ftb/cnotes.hed/1O-HAY-81 08:21103
-------
DAT* FOR EVALUATION OF BIODEQRAD4TION, HYDROLYSIS 4 PHOTOLYSIS (BHP) - Continued
Hazardous Substance
1 CAS No.I B | H
P 1 Data / Comments
2, 1-Dlnltrotoluene
1 1 1
1 1211121 I
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
I Blodegradatlon is alow but oould be significant depending upon relative rates of other Tate
I processes. (Ref.1)
1 52ft degradation of 100 ppm solution by phenol adapted baoterla In 3 hours.
I Amenable to biological treatment at P0TW when diluted. (Ref.3)
j Inhibition of baoterla cell multiplication starts at 57 mg/1. (Pseudomonas putlda) (Ref.2)
1
1 Hydrolysis Is hLghly Improbable based on the compounds" resistance to eleotrophlllo attack.
1 (Ref.1)
1
1 Phyotolysls la probably responsible for color development In munition plant effluents. (Ref.1)
I
1 Oxidation may be Important In highly aerated waters. (Ref.1)
1
2,6-Dlnltrotoluene
1 II
I 6062021 I
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
1 Blodegradatlon Is slow but oould be significant depending upon relative rates of other fate
1 processes. (Ref.1)
1
1 Hydrolysis Is highly Improbable based on the compound's resistance to eleotrophlllo attack.
1 (Ref.1)
1
I Photolysis la probably responsible for color development In munition plant effluents. (Ref.1)
I
1,2-Dlphenylhydrazine
1 1226671 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
1 Vertebrates transform this pollutant to aniline and benzidine; no specific data are available.
1 (Ref.1)
1
1 Hydrolysis Is not expeoted to occur under environmental conditions. (Ref.1)
1
1 Although photoreduotlon to aniline Is not expeoted to proceed rapidly, It may make a
1 significant contribution to what may be the main pathway to ultimate destruction. (Ref.1)
1
1 Bloaccuaulatlon Is highly probable based on partition ooefflolents; no environmental data
1 available. (Ref.1)
i
EplchLorohydrln
1 1068961 I
1 1 1
1 1 1
1 1 1
I
1 Blodegradatlon may occur. (Ref.3)
1
1 Inhibition of baoterla cell multiplication starts at 55 mg/1. (Pseudomonas putLda) (Ref.2)
1
EthanathLoamlde
1 625551 1
1 1 1
1
1 B0D5 3 0ft ThOD. (Ref.2)
Ethyl carbamate (Urethan)
1 517961 I
1 1 1
1
I Mo data
i
Ethyl t,f-dlchlorobenzllate
1 5101561 I
1 1 1
I
I No data
i
Ethyl methanesulfonate
1 625001 I
1 1 1
i
I No data
1
Ethylene dlbromide
1 1069311 1
1 1 1
I
1 No data
i
RQTBL/bhpnotes.ftb/onotes.hed/IO-MAY-81 08i21«03
-------
DATA FOR EVALUATION OF BIODBGRADATION, HYDROLYSIS I PHOTOLYSIS (BHP) - Continued
Hazardous Substance 1
CAS No.I B I H
P I Data / Comments
Ethylene oxide 1
1 1
752101 I
1 1
1 1
1 1
1 1
1 1
| |
1
1 Negative potential Tor accumulation. (Ref.3)
1
1 Ethylene oxide (b.p. 10.7°C) la flammable and explosive In air at concentrations >31*
1 Concentrations or 0.5 to 10)1 In air will kill most animals In a short time. It Is soluble In
I water. The aqueous solution la fairly stable, but Is alouly hydrolyzed to ethylene glycol.
1 (Ref.1)
I
Ethylenethlourea 1
961571 1
| |
1
1 No data
j
Formaldehyde 1
1 1
500001 I |
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
| |
1 BOD15 3 nn f ThOD - less than 1 day aoollmated seed;
®"®1/3 B 52$ ThOD - aewage treatment seed|
1 BODj s 0> ThOD 620°C with HeOH aoollmated aeed. feed oono. s 500 mg/1. (Ref.6)
1 Subjeot to blodegradatlon and photochemical attack at the unsaturated bondi
1 BOD,. B Hff ThOD, aotlvated sludge)
1 B0D5 = 94* ThOD. (Ref.3)
1 B0D5 = 60$ ThOD. (Ref.2)
Olycldylaldehyde I
7653111 1
| |
1
1 No data
1
Guanldlne, H-nltroao-N-methyl-N'-nitro-l
702571 1
1 j
i
1 Mo data
1
HeptachXor I
761181 I
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 1
1 |
•
1 Slow blodegradatlon. (Ref.1)
1
1 Hydrolysis la a rapid prooeaa for heptao»lor In aolutloni Half-life = 1 to 3 days In the
1 environment, with the hydrolysis produota 1-hydroxyohlordene and heptaohlor epoxide;
1
1 Stable to hydrolysis.
1 Heptaohlor la said to be stable to at least 160°C and to light moisture, air and oxidizing
1 agents, aolda and alkali. Heptachlor la rather eaally converted to the epoxide in soil and
I plants. (Ref.1)
1
1 Hill undergo photolysis at undetermined rate to form deohlorlnated heptaohlor Isomers &
1 heptaohlor epoxide.
1
1 High food ohaln contamination potential. (Ref.3)
Heptachlor epoxide 1
10215731 1
1 1
1 1
1 1
1 1
1 1
1
1 Blodegradatlon is very slow, but could be Important. (Ref.1)
1
1 Hydrolysis la not an Important process. (Ref.1)
1 No quantitative Information was available concerning photolysis. (Ref.1)
1
RQTBL/bhpnotea .ftb/cnotes .hed/10-MAY-81 08t21t0B
-------
DATA FOR EVALUATION OP BIODEORADATION, HYDROLYSIS & PHOTOLYSIS (BHP) - Continued
Hazardoua Substance
1 CAS No.l B I H
P I Data / Comments
Hexachlorobenzene
1 1 1
1 1187111 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
I Blodegradatlon occurs extremely slowly, If at all. (Ref.1)
1
1 Degradation by Pseudomonasi 200 og/l 03O°c. (Ref.2)
| parenti 0t ring disruption In 120 hour
| mutant* 01 ring disruption In 120 hour
1
I Hydrolysis does not ooour In ambient waters. (Ref.1)
1 Estimated half-life In river water = 0.3-3 days. In soli 1 years. (Ref.3)
1
1 Photolysis does not ooour readily. (Ref.1)
i
Hexaohlorobutadlene
1 B76B3I 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
I I 1
1
1 Ho Information was found In the reviewed literature on the blodegradatlon or hydrolysis of
1 hexaohlorobutadlene.
1
I Hexaohlorobutadlene does not strongly absorb light above 290 mm. Photolysis Is therefore
1 probably not Important. (Ref.1)
1
1 Positive potential for aooumulatlon from water. (Ref.3)
1
Hexachlorooyclopentadlene
1 II
1 7717711 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 |
1 Blodegradatlon'does not appear to be an important fate prooess. (Ref.1)
1
1 Hydrolysis appears to be an Important fate prooess. (Ref.1)
1 Half-life for hydrolysis a 11 days (same produot as photolysis). Forms HCl. (Ref.1)
1
1 Photo-oxldatlon may ooour. (Ref.1)
1
1 Near-surface photolysis Is an Important prooess. (Ref.1)
I Half-life for photolysis In water - 11 minutes (forms tetraahlorooyclopentadlenone hydrate);
1
1 Volatilization appears to be Important in flowing waters. (Ref.1)
i
Hexachloroethane
1 677211 I
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
i
1 Little or no removal In a P0TW.
1 No speolflo Information was t. jnd concerning the blodegradatlon or hydrolysis of
1 hexaohloroethane. (Ref.1)
1
1 Hexaohloroethane probably does not undergo photo-dlssoolatlon In the aquatlo or lower
1 atmospheric environments. Photodlssoolatlon In the stratosphere may be Important. (Ref.1)
1
1 Evidence is inoonoluslve as to the relative Importance of volatilization. (Ref.1)
I
Hydrazine
1 1 1
1 3020121 I
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
1 Rapidly reaots with dissolved 02 to form NHhOH and N2> decompsltlon accelerated by UV
1 light; no potential for bloaocumlatlon. (Ref.3)
1
1 Impact on blodegradatlon processes) 75$ Inhibition of nitrification prooess of non-acclimated
1 aotlvated sludge at IB mg/1. (Ref.2)
I
Indenof1,2,3-cd]pyrene
1 1 1
1 1933951 1
1 1 1
1
1 Little likelihood or significant blodegradatlon.
1
Isosafrole
i i i
1 1205811 I
1 1 1
i
1 No data
Kepone
1 1135001 |
1 1 1
1
1 Bloacoumulates; not amenable to POTW treatment. (Ref.3)
1
RQTBL/bhpnotea .ftb/cnotes.hed/1O-HAY-81 08:21103
-------
PITA FOR EVALUATION OP BIODEQRAQATION, HYDROLYSIS & PHOTOLYSIS (BHP) - Continued
Hazardous Subatanoe
I CAS No. | B 1 H
P 1 Data / Comments
Laslooarplne
i 1 \
1 3033
-------
Hazardous Substanoe
H-Nltrosodl-n-butylamine
N-H1troaod1ethanolam1ne
N-Hltroaodlethylamlne
H-Hltroaodlmethylamlne
H-Hltrosodl-n-propylamine
H-H1troso-H-ethylurea
N-Hltroso-H-methylurea
H-H1troao-H-methylurethane
N-Hltroaomethylvinyl amine
N-Nltroaoplperldine
H-Hltroaopyrrolldlna
Parathlon
Pentachloronltrobenzene
BIODEGRADATION, HTDROLTSIS ft PHOTOLYSIS (BHP) - Continued
I Data / Comments
Resists hydrolysis. (Ref.3)
Ho data
The half-life Is between 5 and 15 days when present at 10 ng/1 In well water by hydrolyslsi
Hydrolysis ooours only In aoldlo media. (Ref.3)
Low potential for aooumulatlon.
Slow photolyalsi Half-life a 79 hours In aerated distilled H^o at Initial oono. of 71 mg/lj
Ho hydrolysis or blodegradatlon. (Ref.1)
Photolysis similar to dlmethylnltrosaalnei Half-life Is 79 hours In aerated, distilled
Ho hydrolysis, alow blodegradatlon. (Ref.1)
No data
No data
No data
No data
No data
No data
High potential for bloooncentratlon.
Photolysis produots are quite toxlo. (Ref.5)
Parathlon Is relatively resistant to hydrolysis. (Ref.1)
Hydrolysis half-llfes
(a) half-lire 6 pH
(b) half-life 6 pH
(o) half-life 6 pH
Half-life of Paraxoni
(a) half-life « pH
(b) half-life 6 pH
(o) half-life 6 pH
No data
RQTBL/bhpnotes.ftb/cnotes.hed/10-MAY-81 08i 21103
= 3*1 = 1162 ^ours (forms Paraxon (toxlo))
= 7.4 = 2591 hours (forms Paraxon (toxlo))
= 10.4 3 33.2 hours (forma Paraxon (toxlo))
= 3.1 = 1726 (forms p-Nltrophenol (toxlo))
= 7.1 = 3450 (forms p-Nltrophenol (toxlo))
= 10.4 = 6.0 (forms p-Nltrophenol (toxlo)).
-------
Hazardous Substance
DATA FOR EVALUATION OP BIODBGRADATION, HYDROLYSIS « PHOTOLYSIS (BHP) - Continued
CAS No.I B I H I P I Data / Comments
Pentachlorophenol
87865
In a well-dooumented study of a Fresh-Mater lake, two aootdental spills were metabolized to
pentachloroanlsole and a mixture of ohlorlnated phenols. (Ref.1)
No speolflo Information was found regarding hydrolyslsi hydrolysis Is thought HOT to be an
Important prooess. (Ref.1)
Photolysis of pentachlorophenol Is reported to ooour under natural conditions and Lt Is
probably an Important process near the water surface. (Ref.1)
Photolysis of aqueous PCP by sunlight produoes a series of degradation products In which
chlorine atoms are replaoed by hydroxyl groups followed by slr-oxldatlon to qulnones and other
reactions. Principal produots are C6ci,,(oh)2, C6Cl202(0H)2, C6Cl5-0-
c6"^(On),C6C11,(OH)-C-C6Cl ^(OH), and CgClqfOH^O^Cl^. (Ref.H)
Volatilization probably does not arreot the aquatlo fate of this pollutant.
Does bloaocumulate.
Phenacetln
Polychlorlnated blphenyl a (PCBs)
Potassium arsenate
1
1 77801110
1
Potassium arsenlte
1
110121502
Potassium bichromate
1
1 7770509
i
Potassium ohromate
l
1 7769006
1
1,3-Propane sultone
1
1 1120714
1
Saccharin and salts
1
1 81072
1
Safrole
1
1 9*1597
1
62112
1336363
Blodegradatloni decomposition rate In soil suspensions* >72 days for complete disappearance.
(Ref.2) |
Wastewater treatments degradation by Pseudomonasi 200 mg/l at 30°C
Parents 7f ring disruption In 120 hours
Hutanti 26J ring disruption In 120 hours. (Ref.2)
Half-life for photolysis I).75 hours - 1.5 daysi Produots = ohloranlllo acid, ohlorlnated
phenols, ohlorlnated dlhydroxylenzenesi
Hydrolysis - not lmportanti Blodegradatlon - does blodegrade, produots = pentaohloroanlsole &
chlorinate phenols. Ref. 7
Perslstent/bloaooumulates. (Ref.?)
No data
PCBs are stable to hydrolysis. (Ref.1)
PCBs are stable to oxidation. (Ref.1)
High potential for bloaocumulatlon.
BOD - very slow.
No data
No data
No data
No data
No data
No data
No data
ROTEL/bhpnotes.ftb/onotes.hod/10-HAY-81 08i21s 03
-------
DATA FOR EVALUATION OP BIODEQRADATION, HYDROLYSIS & PHOTOLYSIS (BIIP) - Continued
Hazardous Substance
1 CAS No.l B 1 H
P I Data / Comments
Sodium arsenate
1 1 1
I 76318921 1
1 1 1
1 Ho data
1
Sodium arsenlte
I 77811651 1
I 1 1
1
I Ho data
1
Sodium bichromate
1 II
1105880191 1
1 1 1
1
1 No data
1
Sodium chromate
1 77751131 1
1 1 1
i
I No data
i
Sulfur selenlde
I 71805611 |
¦ I |
1
1 No data
I
Streptozotocln
1188836611 I
1 1 1
l
1 No data
1
Strontium ohrooate
1 77890621 I
1 1 1
i
I No data
I
2,3,7,8-Tetrachlorodlbenzo-p-dloxln
(TCDD)
1 17460161 I
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
1 Half-life for blodegradatlon In HgO - >1year. (Ref.1)
I Hydrolysis does not oaour. (Ref.1)
»
1 Can photolyze If reaotlve substrates are available. (Ref.1)
j Bloaocumulatlon lllcelyi Can photolyze In solvent with ????( No hydrolysis likely.
i
1,1,1,2-Tetrachloroethane
1 II
1 6302061 I
1 1 1
I
1 No data
I
1,1,2,2-Tetrachloroethane
1 793151 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1 1 1
1
I Bloacoumulatlon unlikely.
1 Blodegradatlon probably occurs at a low rate, If at all. (Ref.1)
I
1 Hydrolysis appears to ooour too slowly to be a significant fate process. (Ref.1)
1
1 Photolysis la probably not significant in aquatlo systems; photo-dlssoolatlon in the
1 stratosphere Is probably a significant fate process for this compound. (Ref.1)
1
1 Since the vapor pressure of this compound Is reasonably high, volatilization probably serves
1 as the primary transport prooess.
1
RQTBL/bhpnotes.ftb/cnotes.hed/IO-MAY-81 08:21:03
-------
Hazardous Substance
DATA FOR EVALUATION
CAS Mo.I B 1 H
OF BIODEGRADATION, HXDROLYSIS » PHOTOLYSIS (BHP) - Continued
P I Data / Comments
Tetrachloroethyiene
Thiourea
o-Toluldlne hydrochloride
Toxaphene
1,1,2-Trlohloroethane
127161
62566
636215
8001352
79005
Some evldenoe of blodegradatlon In seawater. (Ref.1)
There Is evldenoe that metabolic produots of tetraohloroethylene from higher organisms can be
blodegraded by mlcrogranlsms in sea water. (Ref.1)
Hydrolysis probably oocurs too slowly to be a significant fate process; Half-life for
hydrolysis n 8.8 hours. (Ref.1)
Photolysis - substance Is photo-oxldiced before photolysis can ocouri
Photolysis probably does not occur. Photo-oxidation destroys tetraohloroethylene, before It
can reaoh the stratosphere, which Is the region above the ozone layer where direct photolysis
could ooour. (Ref.1)
Photolysis gives phosgene & trlohloroaoetyl chloride.
Photo-oxldatlon In the troposphere appears to be the predominant fate of this compound. Photo-
oxldatlon in the aquatlo environment occurs at a slow rate. Direct oxidation at ambient
conditions does not ooour in the aquatlo or atmospherlo environment. (Ref.1)
Volatilization Is the primary transport process. (Ref,1)
I
Impact on water "pollution treatment processes! 75$ reduction of nitrification process of
nonacollimited aotlvated sludge at 0.075 mg/1. (Ref.2)
Ho data
Does not blodegrade In aeroblo systems but does In unaeoroblo systems. (Ref.1)
Half-life for hydrolysis = >10 years. (Ref.1)
Half-life for photolysis in HjO B >10 years. (Ref.1)
Positive potential for bloaooinulatloni Dehydrohalogenator In strong sunlight. (Ref.1)
Blodegradatlon probably oocurs at a slow rate. (Ref.1)
Hydrolysis probably ocours too slowly to be a significant fate process. (Ref.1)
Photolysis Is probably not algnirioant in aquatlo systems. Photodlssoclatlon In the
stratosphere may be a significant fate of the compound. (Ref.1)
Volatilisation probably servti as the primary transport process. (Ref.1)
RQTBL/bhpnotes.ftb/cnotes.bed/10-HAT-S1 08:21j 03
-------
Hazardous Substance
DATA FOR EVALUATION
CAS Ho.I B I H
OF BIODEGRADATION, HYDROLYSIS & PHOTOLYSIS (BHP) - Continued
P I Data / Comments
Trlchloroethylene
Trlchlorophenol
2.1.5-Trlchlorophenol
2.1.6-Trlohlorophenol
Trls(2,3-dlbrocsopropyI) phosphate
Trypan blue
Uracil mustard
79016
25167622
95951
68062
126727
72571
66751
There la evidence that metabolic products of trlchloroethylene from higher organisms can be
blodegraded by microorganisms In sea water. (Hef.1)
B°D5 = 0* ThOD. (Ref.3)
Inhibition of bacteria oell multiplication starts at 65 mg/1. (Pseudomonas putlda) (Ref.2)
Hydrolysis probably occurs too slowly to be a significant fate process. (Ref.1)
Photolysis probably does not occur since photo-oxldatlon destroys trlchloroethylene before It
can reach the stratosphere. (Ref.1)
Trlchloroethylene has a short tropospherlo lifetime of approximately 1 days; Photolysis yields
phosgene and dlohloraoetyl chloride;
After 20 days no blochemloal oxidation ooourred; TCE Is concentrated In aquatic speoles.
See data for specific Isomers.
BOD 0.91 - 4.If with pure bacteria oulturet Half-life In surface water = 1.9 days.
Hydrolyzes at OP (~113°C). Her. 7
Blodegradatlonf Decomposition In suspended soils >72 days for complete disappearance. (Ref.2)
Blodegradatlon has been demonstrated in soil samples and in acclimated sewage sludge but It Is
uncertain as a process In ambient surface waters. (Ref.1)
Blodegradatlom
(a) 7-10 days needed to remove 951 of 300 ppo 2,1,6-trlchlorophenol using sludge bacteria.
(b) at 100 ppo, 70< removed In 3 hours
(o) In soil 5-13 days for complete removal. (Ref.1)
Decomposition In soil suspensions! 5 days for complete disappearance. (Ref.2)
Degradation by Pseudooonasi 200 mg/1 630°C
Parenti 100J ring disruption In 120 hours
Mutants 100J ring disruption in 50 hours. (Ref.2)
Bloohemlcal oxidation of TCP € 100 mg/1 produced 23) degradation using a phenol adapted seed.
Hydrolysis is not thought to be an environmentally relevant processs. (Ref.1)
Photolysis has been reported but the environmental relevance is uncertain. (Ref.1)
Photolysis - In the presence of electron acceptor can photooxldlze to semlqulnones — (2,6-
dlchlorobenzoqulnones ft 2,6-dlohlorohydro-qulnone).
No data
No data
No data
RQTBL/bhpnotes.ftb/cnotes.hed/1O-MAY-81 08i21:03
-------
DATA FOR EVALUATION OP BIODBqRADATJON, HYDROLYSIS * PHOTOLYSIS (BHP) - Continued
Hazardous Substance
| CAS No.l B 1 H
P 1 Data
Comments
Vinyl ohlorlde
1 II
1 750111 |
1 1 1
1 Resistant to aloroblal degradation. (Ref.1)
1 1 1
1 1 1
1
I Hydrolysis Is probably not a significant Tate of this compound! Hyrdrolysls half-life = <10
1 1 1
1 1 1
I years,
i
(Ref.1)
1 II
1 1 1
¦
1 Photolysis Is not a significant fate pr^oess since photo-oxtdatlon destroys vinyl chloride
1 1 1
1 1 1
1 before
i
It can reach the stratosphere. (Ref.1)
1 II
1 1 1
1 1 1
•
1 Volatilization is the most important transport prooess for vinyl ohlorlde. (Ref.1)
i
REFERENCESi
1 1 1
1 1 1
1 Ref.1 -
"Water-Related Environmental Pate of 129 Priority Pollutants", Vol.142, EPA 110/1-
1 1 1
1 1 1
1
1
79-029 a&b, December 1979.
1 1 1
1 1 1
1
1 Ref.2 -
¦Handbook of Environmental Data on Organlo Chemloala", Karel Verschueren, Van Nostrand
1 1 1
1 1 1
i
¦
Relnhold Company, New York, NY, copyright 1977 by Litton Eduoatlonal Publishing Ino.
1 1 1
1 1 1
1 Ref.3 -
The "Oil and Hazardous Materials Teohnloal Assistance Data Base" (OHHTADS), aooessed
1 1 1
1 1 1
1
I
as a oachlne-searohable database via the BPA/NIH Chemloal Information System (CIS).
1 1 1
1 1 1
1
1 Ref.1 -
1
"Guidelines for the Disposal of Small Quantities of Unused Pestloldes," EPA 670/2-75-
1 1 1
1 1 1
1
|
057, June 1975.
1 II
I • I
1 Ref.5 -
"Report on Environmental Assessment of Pestlolde Regulatory Programs" State Component,
i i i
1
1
Volume 2, State of California Department of Pood and Agrloulture, 1978.
¦ ii
I I l
1
1 Ref.6 -
"Chemloal Struoture Resistant to Aeroblo Bloohemlcal Stabilization," P.J. Ludzack and
l l 1
1
H.B. Bttlnger, 11th Annual Purdue Industrial Haste Conference, Lafayette,
I I I
I I l
1
1
Indiana, Hay 5-7, 1959.
RQTBL/bhpnotes.ftb/cnotes .hed/IO-MAY-81 08121103
-------
Appendix B
TECHNICAL SUPPORT DOCUMENT AND SUMMARY TABLE FOR
THE RANKING OF HAZARDOUS CHEMICALS BASED ON CARCINOGENICITY
B-l
-------
United States
Environmental Protection
Agency
EXTERNAL REVIEW DRAFT
0HEA-C-073
JULY 1983
<&EPA Research and
Development
TECHNICAL SUPPORT DOCUMENT AND SUMMARY TABLE FOR THE
RANKING OF HAZARDOUS CHEMICALS BASED ON CARCINOGENICITY
Prepared for
OFFICE OF EMERGENCY AND REMEDIAL RESPONSE
Prepared by
Office of Health and
Environmental Assessment
Washington DC 20460
DRAFT
DO NOT QUOTE OR CITE
This document is a preliminary draft. It has not been formally released by the
Environmental Portection Agency and should not at this stage be construed to
represent Agency policy. It is being circulated for comments on its technical
merit and policy implications.
B-3
-------
SRC TR-83-643
DRAFT
DO NOT QUOTE OR
FINAL DRAFT CITE
TECHNICAL SUPPORT DOCUMENT AND SUMMARY TABLE
FOR THE RANKING OF HAZARDOUS CHEMICALS
BASED ON CARCINOGENICITY
Prepared by:
Joseph Santodonato and John Becker
Center for Chemical Hazard Assessment
Syracuse Research Corporation
Merrill Lane
Syracuse, NY 13210
Contract No. 68-03-3112
TASK 21
Prepared for:
Environmental Criteria and Assessment Office
U.S. Environmental Protection Agency
Cincinnati, OH 45268
Project Officer: Mr. John Risher
Technical Project Monitor: Dr. Margaret Chu, CAG, Washington
Submitted to:
Carcinogen Assessment Group
Office of Health and Environmental Assessment
U.S. Environmental Protection Agency
Washington, DC 20460
July 11, 1983
B-4
-------
DISCLAIMER
This document is intended for review purposes only and does not
constitute Agency policy. Mention of trade names or commerical products
does not constitute Agency endorsement or recommendation for use.
B-5
-------
PREFACE
This document has been prepared for the Emergency Response Division,
Office of Emergency and Remedial Response, for use in proposed rulemaking
under the Comprehensive Environmental Response, Compensation and Liability
Act of 1980. The data are Intended to be used as a means for ranking
suspect carcinogens and are one source of scientific information for
adjusting reportable quantities of hazardous materials. The data herein
without additional analysis should not be used for risk assessment purposes.
B-6
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TABLE OF CONTENTS
CONTRIBUTORS AND REVIEWERS
T. INTRODUCTION
2. LITERATURE SEARCH AND INFORMATION SOURCES
3. APPROACH TO DATA EVALUATION
3.1. SUMMARIZING THE WEIGHT-OF-EVIDENCE FOR CARCINOGENICITY
USING THE INTERNATIONAL AGENCY FOR RESEARCH ON CANCER
(IARC) CRITERIA
3.2. ESTIMATION OF CARCINOGENIC POTENCY
3.2.1. Dose Expressed as mg/kg/day
3.2.1.1. CALCULATION FOR DOSE (d) IN mg/kg/day FROM
ORAL DOSE EXPRESSED AS DIETARY CONCENTRATION
3.2.1.1.1. Oral Dose for Calculation of Potency
Factor Based on Dietary Concentration
3.2.1.2. CALCULATION OF DOSE (d) IN mg/kg/day FROM
ORAL DOSE EXPRESSED AS WATER CONCENTRATION
3.2.1.2.1. Oral Dose for Calculation of Potency
Factor Based on Drinking Water Exposures
3.2.1.3. CALCULATION OF POTENCY FACTOR BASED ON
INHALATION EXPOSURES
3.3. GROUPING OF CHEMICALS BASED ON CARCINOGENIC POTENCY
3.4. OVERALL HAZARD RANKING BASED ON COMBINED QUALITATIVE AND
QUANTITATIVE ASSESSMENTS-
3.4.1. Use of Chemical and Environmental Fate and Transforma-
tion Data in Hazard Ranking of Metals and Their Salts
3.^.2. Special Problems in Hazard Ranking of Chemicals
Associated With Multimedia Exposure in Humans
4. 'SUMMARY OF CARCINOGENIC HAZARD RANKING
5. REFERENCES
6. SUMMARY TABLE
B-7
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CONTRIBUTORS AND REVIEWERS
The Carcinogen Assessment Group in the Office of Health and Environmental
Assessment had the primary responsibility for methodology development and peer
review of the hazard ranking of carcinogens. Participating members are as
Roy E. Albert, M.D., Chairman
Elizabeth L. Anderson, Ph.D.
Larry D. Anderson, Ph.D.
Steven Bayard, Ph.D.
David L. Baylias, M.S.
Chao V. Chen, Ph.D.
Margaret M.L. Chu, Ph.D., Project Director
Herman J. Gibb, 3.5., M.P.R.
Bernard H. Habennan, D.V.M., M.S.
Charalingayya B. Hiremath, Ph.D.
Robert E. Mcflaughy, Ph.D.
Dhara 7. Singh, D.V.M., Ph.D.
To
-------
EPA Internal
Donald Barnes
Judy Bellln
Barbara Davis
Patrick Tobin
Office of Pesticides and Toxic Substances
Office of Solid Waste
Office of Waste Programs Enforcement
Office of Water Regulations and Standards
B-9
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1. INTRODUCTION
The purpose of ranking hazardous chemicals based on carcinogenicity is to
provide the technical background for the Emergency Response Division (ERD) in
the11 Office of Emergency and Remedial Response to adjust the reportable
quantities (HQs) under^ Section' 102 of1 hazardous substances designated in
Section 101(14) of the "Comprehensive Environmental Response, Compensation and
Liability Act (CERCLA or Superfund)" of 1980. Section 103 of CESCLA requires
immediate notification from any person in charge of a vessel or an offshore or
an onshore facility who releases an amount of a hazardous substance equal to
or greater than its RQ. Under CERCLA Section 102(b), the RQ of any hazardous
substance designated in Section 101(14) is 1 lb unless a different' RQ has been
established pursuant to Section 311(b) (4) of the Federal Water Pollution
Control Act. These are statutory RQs for the CERCLA Section 101(14) hazardous
substance unless and until the Administration of EPA promulgates regulations
establishing different quantities to be reported when released. CERCLA also
permits EPA to establish a single RQ for each hazardous substance regardless
of the environmental medium into which the substance is released.
The Emergency Response Division of the Office of Emergency and Remedial
Response proposed to use "Selected Criteria Processing (SCP)" to adjust the
statutory RQs. SC? includes ignitability, reactivity, carcinogenicity,
aquatic toxicity, acute mammalian toxicity (oral, dermal, inhalation) and
chronic toxicity as six primary criteria for adjusting RQs. The RQ for each
hazardous substance is the lowest numerical value of all applicable RQs
B-10
-------
derived from the primary criteria. The RQ is then readjusted using biodegrad-
abillty, hydrolysis, and photolysis a3 secondary criteria.
In the end of'January, 1982, the Emergency Response Division requested
the Carcinogen Assessment Croup (CAG) of the Office of Research and
Development of the U.S. Environmental Protection Agency to provide scientific
support in the implementation of adjusting BQs using carcinogenicity as a
hazard endpoint. On June 24, 1982, the CAG forwarded a preliminary draft of
the method to be used in the evaluation of data in the literature and a scheme
for ranking the list of suspected carcinogens given to the CAG by ERD. It is
understood that as the assessment proceeds modification of the ranking scheme
may be necessary.
The acquisition and evaluation of data are performed under contract to
Syracuse Research Corporation under the direction of the CAG. The CAG had the
priaary responsibility for methodology development and peer review of the
hazard ranking of carcinogens.
Additional assistance in the peer review and critique of conclusions,
extrapolations and data summarization presented in this document was provided
by: Dr. Herbert Cornish of the School of Public Health, University of
Michigan; Dr. Rolf Hartung of the School of Public Health, University of
Michigan; and Dr. Benjamin Van Duuren of the Institute of Environmental
Medicine, New York University Medical Center.
The results of this effort are summarized in the present technical
support document. The data contained herein are Intended to be used as a
means, of ranking suspect carcinogens and as one source of scientific
information for adjusting reportable quantities of hazardous materials when
carcinogenic potential is used as the health hazard endpoint of concern. The
B—11
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data herein without additional analysis should not be used for risk
assessment.
The following sections of this report present the objectives and method-
ology applied in arriving at a carcinogenic hazard assessment for each of the
chemicals under study. The major findings are summarized in tabular form at
the end of this report. A more detailed discussion of the> data on the
carcinogenic potential for each chemical under study, as well as. pertinent
references to the published scientific literature, is contained in a profile
far each chemical. The profiles collectively form an appendix to, but are not
attached as part of, this summary document. The profiles can be accessed
separately.
B-12
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2. LITERATURE SEARCH AHD INFORMATIOH SOURCES
The objective of the information search was to identify all relevant
published reports concerning the potential carcinogenicity of the chemicals
under study. Reports of human experience as well as the published results of
controlled investigations with experimental laboratory animals were sought
from the worldwide biomedical literature. In order that the information
search be exhaustive, both on-line and hard-copy sources of bibliographic
information were consulted. A list of the data bases searched for this
project is presented in Table 2-1. On-line searches were extended as far back
as the data bases would allow; retrieval of historical data was accomplished
through searches of hard-copy sources and through "tree-searching" of bibli-
ographies from relevant publications. Even though it is recognized that a
certain amount of duplication is inevitable when searching both on-line and
manual information sources, neither source alone is sufficient for complete
coverage of the published toxicology literature. Every attempt has been made
to rely upon primary publications as opposed to data summaries or abstracts
contained in secondary sources such as monographs, surveys, review articles,
criteria documents, etc.
Searches were conducted using specific Chemical Abstracts Service (CAS)
names, CAS registry numbers, common synonyms, designated substructures, and
keywords related to carcinogenicity/mutagenicity when appropriate. All of the
chemi'cals included in the study were first searched in the CHEMLINE on-line
chemical dictionary to identify proper CAS registry numbers and all available
B-13
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TABLE 2-1. Sources of Bibliographic and Numerical Information
for Suspect Carcinogens
On-Llne Sources
CHEMLINE (National Library of Medicine)
RTECS (National Library of Medicine)
Toxicology Data Bank (National Library of Medicine)
TOXLINE (National Library of Medicine)
CANCERLINE (National Library of Medicine)
Chemical Abstracts (Dialog Information Services)
Hard-Copy Sources
"Survey of Can pounds Tested for Carcinogenicity," PHS-1^9 (all volumes)
"International Agency for Research on Cancer - Monographs on the Evalua-
tion of Carcinogenic Risks of Chemicals to Humans," Volumes 1-29
National Toxicology Program, Carcinogenesis Testing Program, "Chemicals
on Standard Protocol" (as of October 7, 1982)
National Cancer Institute - Technical Report Series
"Genetox Carcinogen List" (as of July 9» 1982)
"TOX-TIPS" (National Library of Medicine)
"Chemical Carcinogens," C.E. Searle (ed.)f ACS Monograph 173, 1976
"Documentation of the Threshold Limit Values for Substances in Workroom
Air," American Conference of Governmental Industrial Hygienists
"Ambient Water Quality Criteria Documents," U.S. EPA, ORD
National Institute for Occupational Safety and Health - Criteria Docu-
ments, Technical Reports, Special Occupational Hazard Reviews, Current
Intelligence Bulletins, Information Profiles on Potential Occupational
Hazards
"Current Contents - Life Sciences," Institute for Scientific Information
B-14
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synonyms. Subsequent on-line searches followed the steps outlined in
Figure 2-1.
In most cases, the decision to obtain an article in hard copy was based
upon a review of information contained in abstracts which were printed on-
line. Primary articles were selected or rejected on the basis of title alone
only when an abstract was not available on-line, or if the article was identi-
fied during a "tree search" of bibliographies from pertinent publications.
For the sake of completeness, many articles were obtained in hard copy even if
it was not clear from the title that useful data for assessment of carcino-
genic risk would be contained in the report. Thus, a large body of literature
relating to the chemicals under study was collected, although no attempt was
made to cite all the articles retrieved.
B-15
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MO
ru
(II
(21
131
(4)
(91
(•I
(71
(•I
(•I
110)
START
STATE SPECIFIC INFORMATION NEEDS
DEVELOP KEYWORO UST
TRANSLATE KEYWOROS INTO QATASASE ¦
SPECIFIC1NOEXING TERMS
NO
I
(111
SELICT OATA BASES
EXECUTE SEARCH STRATEGY
TYPE BIBUOORAMtCOTATIONS
IB UST OF OTATIOOT RELEVANT TO
INFORMATION NEEDED?
TYT* MOST RELEVANT CITATIONS IN
FULL FORMAT to OBTAIN INOEX TERMS!
UST OF CAS REGISTRY NUMBERS USED
IN EACM SPECIFIC REFERENCE
AOO ANY NEW INOEX TERM TO SEARCH
«TRATEOY»
SSLCCT A NO OSTAIN HARD CCPY OF
REFERENCES
CD
stop
Figure 2-1. Flowchart of Steps in Searching On-line Data Bases
B-16
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3. APPHOACH TO DATA EVALUATION
Each primary publication retrieved during the literature search phase of
the project oust be critically evaluated both with respect to its relevance to
an assessment of carcinogenicity and to the quality of the reported data.
Moreover it is important to realize that a distinction must be made between
the evaluation of the quality of all biological data and a quantitative
estimate of the strength of the substance to produce the effect. The qualita^
tive assessments (evaluations) are expressed as an overall "weight-of-
evidence;' of the likelihood of an agent to be a human carcinogen. A quantita-
tive assessment, on the other hand, attempts to determine or predict the
strength (potency) of the agent to elicit a carcinogenic response. Most
quantitative assessments rely upon sane form of a mathematical extrapolation
model to predict the outcome of exposure to very low doses of a carcinogen
(see Section 3*2.). This has Inherent uncertainties.
It is import"int to recognize that many published studies may be accept-
able to provide qualitative evidence of carcinogenicity, while at the same
time being inappropriate for quantitative estimation of carcinogenic potency.
This is particularly true in cases where the results of animal bioassays are
used to predict the prevalence of certain types of tumors in exposed human
populations. In these situations it becanes necessary to consider the
relevance of the route of absorption of the test substance in the experimental
animals as can pared to the anticipated route of exposure in hunans. For
example, the results of animal studies in which test substances were adminis-
tered by intravenous or intramuscular injection may provide strong qualitative
B-17
-------
evidence of carcinogenic potential and yet be inappropriate to predict the
tumor incidence in humans resulting from ingestion or inhalation of the
substance. The problem is usually compounded by a lack of data concerning the
extent of absorption from different routes of exposure (i.e., oral, inhala-
tion, dermal contact), thereby leading to inaccurate estimates of actual
absorbed doses.
Before a published study can be used to support either a qualitative or
quantitative assessment of carcinogenic potential of an agent, several
criteria should be set. These general criteria, which are applied by
reviewers when evaluating the output of a literature search, are listed below:
factor; Experimental Design
Scoring Elements;
1. What are the objectives of the study?
2. Does the design address the issues?
3. Does the design represent the state-of-the-art?
4. Are there areas which might produce ambiguous results?
5. Were the sampling and handling procedures adequate?
Factor: Experimental Procedure
Scoring Elements:
1. Were logical methods followed?
2. Were any variations from design noted, explained and/or con-
sidered in reporting results?
3. Were analytical and quantitative parameters provided?
B-18
-------
Factor: Results and Conclusions
Scoring Elements:
1. Were sufficient data presented to allow establishment of a
credible case?
2. Were the results expressed understandable?
3. Were results statistically valid?
4. Were the investigators' conclusions supported by the results?
5* Does the paper allow for additional conclusions to be reached
concerning correlation of results with the findings of other
investigators?
A publication need not necessarily be rejected from consideration if all of
the above criteria are not met, although deficiencies in the study should be
indicated by the reviewer if the data are intended to be used for qualitative
and quantitative assessment purposes.
Because of the large number of chemicals evaluated in the present study,
it was necessary to be as systematic as possible in conducting both the quali-
tative and quantitative assessment of carcinogenic potential. An approach was
developed which would facilitate the grouping of chemicals based on the
overall weight-of-evidence of carcinogenicity and on the calculated carcino-
genic potency.
3.1. SDWiAHIZING THE WETGHT-0F-S7XDEHC2 FOR CARCBKXEHICITT USING THE DiTZH-
HATIOHAL AGENCT FOR RESEARCH ON CANCER (IABC) CRITERIA
The U.S. Environmental Protection Agency has proposed guidelines calling
for a qualitative weight-of-evldence judgement concerning the likelihood that
a substance may be carcinogenic to humans (U.S. EPA, 1976). Obviously, any
B-19
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system which relies upon subjective Judgement will be influenced by the person
who evaluates the weight-of-evidence. Variability can be minimized, however,
by adopting a consistent set of evaluation criteria which a knowledgeable
scientist or group of scientists can apply. Moreover, factors can be speci-
fied that will allow the qualitative evidence to be stratified into levels of
increasing support for establishing; carcinogenic potential to humans.
Ideally, the weight-of-evidence approach should be applicable to situations
involving exposure of either humans or experimental animals to potential
carcinogens.
A method has been developed and used for the past 70 years by the Inter-
national Agency for Research on Cancer (IARC) which has received widespread
acceptance for qualitative assessment of potential carcinogens (IARC, 1979).
The IARC approach satisfies the need to classify, according to degree of
sufficiency, the evidence for carcinogenicity from experimental animal studies
and human studies. This approach has been applied by IARC Working Groups to
numerous organic and inorganic compounds, and lends itself to situations such
as the present task which requires hazard ranking of large numbers of
substances having varying degrees of evidence in support of carcinogenicity.
The IARC approach, which has been adopted for use in the present study,
is presented below as published by IARC (1979):
Assessment of evidence for carcinogenicity from experimental animal
studies.
These assessments were classified in five groups:
1. Sufficient evidence of carcinogenicity indicates that there is
an increased incidence of malignant tumours: (a) in multiple species or
strains, or (b) in multiple experiments (preferably with different routes
of administration or using different dose levels), or (c) to an unusual
B-20
-------
degree with regard to incidence, site-or type of tumour, or age at onset.
Additional evidence may be provided by data concerning dose-response
effects, as well as information on mutagenicity or chemical structure.
11. Limited evidence of carcinogenicity means that the data suggest
a carcinogenic effect but are limited because: (a) the studies involve a
single species, strain, or experiment; or "(b) the experiments are
restricted by inadequate dosage levels, inadequate duration of exposure
to the agent, Inadequate period of follov-up, poor survival, too few
animals, or Inadequate reporting; or (c) the neoplasms produced often
occur spontaneously or are difficult to classify as malignant by histo-
logical criteria alone (e.g., lung and liver tumours in mice).
ill. Inadequate evidence Indicates that because of major qualitative
or quantitative limitations, the studies cannot be interpreted as showing
either the presence or absence of a carcinogenic effect.
iv. Negative evidence means that within the limits of the tests
used, the chemical is not carcinogenic. The number of negative studies
is small, since in general, studies that show no effect are less likely
to be published than those suggesting carcinogenicity.
v. Ho data indicates that data were not available to the Worldng
Group.
The categories sufficient evidence and limited evidence refer only
to the strength of the experimental evidence that these chemicals are (or
are not) carcinogenic and not to the extent of their carcinogenic
activity. The classification for any chemical may change as new informa-
tion becomes available.
Assessment of evidence for carcinogenicity from human studies
Evidence of carcinogenicity frca human studies cooes frca three main
sources:
1. Case reports of Individual cancer patients who were exposed to
the chemical or process.
2. Descriptive epidemiological studies in which the incidence of
cancer In human populations was found to vary spatially or
temporally with exposure to the agents.
3. Analytical epidemiological (case-control and cohort) studies in
which individual exposure to' the chemical or group of chemicals
was found to be associated with an increased risk of cancer.
Three criteria must be met for a causal association to be inferred
between exposure and human cancer (3):
B-21
-------
1. There id no Identified bias which could explain, the; associa-
tion.
2. The possibility of confounding has been considered and ruled
out as* explaining the association.
3. The association is unlikely to be due to chance.
In general, although a single study may be indicative of a cause-
effect relationship, confidence in inferring a causal association 13
increased when several independent studies are concordant in showing the
association, when the association is strong, when there is a dose-
response relationship, or when a reduction is followed by a reduction in
the incidence of cancer.
The degrees of evidence for carcinogenicity in human studies were
categorized as:
I. Sufficient evidence of carcinogenicity indicates a causal
association between exposure and human cancer.
II. Limited evidence of carcinogenicity indicates a possible
carcinogenic effect in humans, although the data are not sufficient to
demonstrate a causal association.
Hi. Inadequate evidence of carcinogenicity indicates' that the data
are qualitatively or quantitatively insufficient to allow any conclusion
regarding carcinogenicity for humans.
Dividing lines were by no means firaly drawn between sufficient
evidence and limited evidence from animal studies and between inadequate
evidence and limited evidence from both human and animal studies. When
differences of opinion occurred among the members of the Working Group,
the classification was made by majority vote.
Evaluation of the carcinogenic risk to humans
Presently, no objective criteria exist to interpret the animal data
directly in terms of human risk. Thus, in the absence of sufficient
evidence frca human studies, evaluation of the carcinogenic risk to
humans was based on consideration of both the epidemiological and experi-
mental evidence. Furthermore, the breadth of the categories for human
and animal evidence defined above allows substantial variation within
each, and the decisions reached by -the group regarding overall risk
incorporated these differences, even though they could not always be
adequately reflected in the placement of a chemical into a particular
.category. The evidence in support of these decisions is summarized in
the notes for each chemical in the Appendix.
B-22
-------
The chemicals, groups of chemicals, or industrial processes were
placed into one of three groups:
Group 1
The chemical, group of chemicals, or industrial process is carcino-
genic tor numans. fais category was used only wnen tnere was sufficient
evidence to support a causal association between the exposure and cancer.
Croup 2
The chemical or group of chemicals is probably carcinogenic for
humans. This category includes chemicals for which the evidence of human
carcinogenicity is almost 'sufficient' as well as chemicals for which it
is only suggestive. To reflect this range this category haz been divided
into higher (group A) or lower (group B) degrees of evidence. The data
from experimental animal studies played an important role in assigning
chemicals to category 2, and particularly to those in group 5.
Group 3
The chemical or group of chemicals cannot be classified as to its
carcinogenicity for humans.
3.2. ESTIMATION OP CJUJCINCGEHIC POTZHCT
After determining that the qualitative weight-of-evidence for carcino-
genicity of a substance has been met, a quantitative assessment can usually be
performed. Such quantitative assessments are most useful for: (1) estimating
risk for tumor formation associated with a particular level of exposure; and
(2) making comparisons among carcinogenic chemicals based on their estimated
potencies. It is the latter application of quantitative assessment which is
the objective, of the present study.
After the decision has been made that a compound has the potential for
causing cancer in humans, attempts will be made to estimate a potency factor r
defined as 1/EE1Q. ED1Q is the estimated dose associated with a lifetime
cancer risk of 10>. The potency factor F will be used together with the
quantitative weight-of-evidence for carcinogenicity in the ranking of the
carcinogenic hazard potential of the chemicals.
B-23
-------
The potency factor ? is used in place of the potency factor the CAG
normally uses in the estimation of risk because the objective here is to rank
chemicals for their potential to cause carcinogenic harm and not to estimate
risk associated with a particular level of exposure. Furthermore, it is
advantageous to use the potency factor F because it can be estimated without
the use of many assumptions required for calculating and/or using This
is possible because the dose associated with a lifetime cancer risk of 10? is
usually within or close to the experimentally observable range.
Other advantages of the potency factor F are:
a. It is relatively Insensitive to the choice of the dose-response
extrapolation model.
b. The point estimation of which has same- optimal statis-
tical properties, can be used to calculate F. Therefore, it is
not necessary to use the upper-bound estimate which is more
stable for estimating risk at very low doses.
The data used for calculation of the F factor can be derived from either
animal studies, preferably involving exposure over a substantial portion of
the lifespan, or htman studies where excess cancer risk has been associated
with exposure to the agent. Under the multistage theory, the probability of
developing cancer by age t with a constant exposure d is given by
P(t,d) = 1- expC-Q(d) x A(t)]
^
-------
I#
where, Q(d) : ••• and A(t) is some function of t. If only the
cancer risk at a specific tine (age) t is of interest, the form of A(t) need
not be specified. In the cases where only dichotomous data are available, the
formula without the term A(t) (i.e., A(t) = 1) would be used. If the mortal-
ity rates among treatment groups are comparable, use of the formula with or
without A(t) would make no practical difference.
The multistage model currently derives risk levels only for lifetime
exposure. In dealing with experimental data in which the observation period
(Le) is less than the lifespan (L) of the experimeital animal, the potency
factor derived frco the experimental data — which would give a risk estimate
over the Le/L fraction of the animal's lifespan — is increased by a factor of
(L/Le)^ to obtain an estimated potency for full lifetime risk. As explicated
by the EPA (1980): "We ass vane that if the average dose, d, is continued the
age-specific rate of cancer will continue to increase as a constant function
of the background rate. The age-specific rates for humans increase at least
by the 2nd power of the age and often by a considerably high power, as demon-
strated by Doll (1971)* Thus, we would expect the cumulative tumor rate to
increase by at least the 3rd power of age..... This adjustment is concep-
tually consistent with the proportional hazard model proposed by Cox (1972)
and the time-to-tumor model considered by Crtsap et al. (1977)....". Details
of the dose conversion procedure used to provide the necessary input for the
multistage model are presented below.
3.2.1. Dose Expressed as ¦©'leg/day. These data may be used directly if the
length of exposure (le) was equal to the length of the experiment (Le). If
not, a correction is made by multiplying the dose in mg/kg/day by the ratio
B-25
-------
le/Le, where le is the duration of exposure and Le is the duration of the
experiment.
3.2.1.1. CALCULATION FOR DOSE (d) IH as/kg/day FBCH ORAL DOSE EXP HESS ED
12 DIETAHX COHCESTRATION —- If the authors provide information on body weight
and food consumption then d is calculated directly. If these data are not
provided then d may be estimated by using standard food consumption estimates
which are based on the fraction of the body weight (f) consuned as food per
day.
d s (ppo in food x f)
Fraction of (leg) Consumed*
Species f
Mouse 0.13
Rat 0.05
Man 0.028
Cat 0.030
Dog 0.029
Guinea pig 0.028
Hamster 0.083
Monkey 0.042
Rabbit 0.049
Note that ppm in food has units of mg toxicant/kg food and the ratio f
has units of kg food/kg body weight. Thus, the product has units of Eg
toxicant/kg body weight*
3.2.1.1.1. Oral Dose for Calculation of Potmcy Factor Based on Dietary
Concentration — Calculate the dose in mg/kg/day as indicated in Section
3.2.1.1. above and multiply by le/Le.
3.2.1.2. CALCULATION OP DOSS (d) IN a®/kg/day FROM ORAL DGSZ EXPRESSED
IS HATER CONCZXTRATIGN — If the authors provide information on body weight
• U.S. EPA (1980).
B-26
-------
and water consumption then d is calculated directly. If these data are not
available then d may be estimated by using standard water cons imp tion
estimates based on the fraction of the body weight (fw) consuned as water per
day.
d s (ppm in water x fw)
Fraction of WA (legJ Consumed*
Species fw
Mouse 0.17
Bat 0.078
Cat 0.097
Dog 0.025
Guinea pig 0.3U
Hamster 0.25
Monkey 0.13
Rabbit 0.081
Note that ppm in water has units of mg toxicant/liter water and that fw
has units of liters of water/kg body weight. Thus, the product has
units of mg toxicant/kg body weight.
3.2.1.2*1. Oral Dosa for Calculation of Potency Factor Based on prinking
Water Bzpoourea — Calculate the dose in og/kg/day as Indicated in Section
3.2.1.2. above and multiple by le/Le.
3.2.1.3. CALCULATION OP Wl'mUl FACTOR BASiD OK INHALATION EXPOSURES —
The dose, d, in mg/kg/day is calculated as:
d s (I x 7 x r) * VA (kg)
where:
I = the inhalation rate in n^/day (see below)
7 s average concentration of the compound, over a 24-hour period in mg/m^
r 3 absorption factor (assuae 0.5)
• U.S. EPA (1980).
B-27
-------
w =- body weignt of. animals* (reported or- estimated)
= average estimated body weight of experimental animals (see below)
Inhalation Voluaes*
Species I (m^/day)
Mouse [0.0345 (W/0.025)2/3]
Rat [0.105 (W/0.113)2/3]
Hunan 20
Body Weights*
Species WA (kg)
Mouse 0.03
Rat 0.35
Human 70.0
Cat 3.3
Dog 14.0
Guinea pig' 0.43
Hamster 0.12
Monkey 3.5
Rabbit 3.7
The dose calculated from the above procedure oust be adjusted for average
daily dose over the experimental period by multiplying d by le/Le.
3.3. GROUPING OP CHEMICALS BASED OH C1BCDKJGESIC POTSICT
The potency estimates derived as described previously are used to
indicate relative carcinogenic potency within the group of 180 substances
under investigation. Although the numerical values (F factor) themselves are
not of major importance for consideration in this assessment, they are a use-
ful means to separate the chemicals according to high, medlus, and low hazard
• 0.S, E?A (1980).
B-28
-------
potential. When the potency factors are estimated using the multistage model,
they are subsequently categorized Into four groups. Those chemicals with the
highest pot aides are placed into Group 1; the next highest potency chemicals
are placed into Group 2; low potency chemicals are placed' into Group 3; and
the lowest potency chemicals are placed into Group 4 (see Summary Table).
One method of grouping chemicals 1s by putting chemicals with potency
factors (F) above 100 into Group 1; chemicals with potency factors from 10-100
into Group 2; chemicals with potency factors fran 1-10 into Group 3; and
chemicals with potency factors below 1 into Group 4. The major disadvantage
of this method is that the grouping of chemicals with borderline potencies in
between groups is arbitrary. While toxicologic information could be used to
aid the placing, it would be somewhat subjective. Another method of grouping
is analysis for clustering in addition to potency numerical value cut-off
points. However, this approach requires analysis of all chemicals to be
completed before any grouping can be performed, and thus, was not attanpted
for this draft report. The chemicals have been grouped strictly by potency
factor values.
3.4. OVEHALL HAZAHD BAKING BASED ON COMBINED QUALITATIVE AND QUANTITATIVE
ASSESSIESIS
The culmination of the hazard ranldng process undertaken in this study is
accomplished by containing the qualitative weight-of-evidence for carcinogen-
icity (see Section 3.1) with the potency group placement (see Section 3»3) to
arrive at a final hazard ranking for each chemical. Substances are ranked as
highmediizn, or low hazard according to the following scheme.
B-29
-------
Hazard Ranking Scheme for Reportable Quantities under CERCLA
Potency Group
IAflC Group 12 3 4
F>100 F = 10-700 F s 1-10 F<1
1 HI® HIGH MEDIUM LOW
2A HIGH MEDIUM MEDIUM LOW
23 HIGH MEDIUM LOW LOW
3
Cannot Be Ranked In General*
This hasard ranking scheme can accomodate most chemical substances. The two
notable exceptions in which this approach cannot be used are: (1) most of
IAAC Group 3 substances where the substance cannot be classified as to its
carcinogenicity for humans by IAflC criteria*; and (2) where a chemical can be
classified according to IARC criteria but the available data are inadequate
for estimation of a potency factor (e.g., in animal studies where control
groups were not used, numbers of animals treated were not specified, or only a
single dose of test substance was administered). These special situations
require that a more subjective approach be taken to arrive at an overall
hazard ranking.
In the case where no adequate evidence in support of carcinogenicity is
available, other biological endpoints can be used to evaluate hazard poten-
tial. They may range from gross effects,, such as mortality, to more subtle
"The group 3 category includes chemicals for which the evidence from animal
studies is limited or inadequate, and there is no human evidence. For those
with good dose-related data, a potency estimate is determined and a hazard
ran&ng is performed.
B-30
-------
biochemical, physiological, or pathological changes (EPA, 1980). Mutagen-
icity, teratogenicity, and other adverse effects on the reproductive process
are significant toxic effects which can also be used qualitatively to assign
levels of risk in the hazard ranking scheme. Obviously, the scientific judge-
ment of the reviewer will play a major role in arriving at an overall hazard
determination under these conditions. This is, however, outside the scope of
this document.
The use of these endpoints in hazard ranking are found in the drafts
prepared by the Environmental Criteria and Assessment Offlcce (ECAO) of EPA
entitled "HQs For Chronically Toxic Hazardous Substances".
3*4.1. Use of Chemical and Environmental Pata and Transformation Data in
Hazard Ranking of Metals and Their Salts. The chemical and environmental
speciation, oxidation state, solubility, chemical and environmental fate and
half-life, and dlsproportionatlon reactions are Important determinants of the
tojdcity of inorganic compounds. Furthermore, toxicologic data relevant to
potential carcinogenicity and other chronic effects are lacking for many of
the metals and their salts. Therefore, in cases where toxicity data are not
available on a particular metal salt, and an evaluation of the above para-
meters indicates its convertibility to the toxic (i.e., carcinogenic) species
under realistic hunan exposure conditions, then an appropriate hazard ranking
assignment will be performed based on thi3 evidence.
3.4.2. Special Problems in Hazard Hanking of Chemicals Associated With
Multimedia Exposure in Humans. Carcinogenic hazard ranking in the present
study must take into account the potential for multimedia exposure. Thus, all
routes of human exposure (oral, inhalation, and dermal) oust be considered in
the hazard ranking scheme. With the exception of carcinogens, displaying
B-31
-------
pronounced sit^specific or portal of entry effects (e.g., lung or akin
tumors), hazard ranldngs in terms of absorbed dose should be the same for all
routes of exposure to a given chemical. However, it is often not possible to
estimate absorbed dose with any significant degree of accuracy. Consequently,
extrapolation of potency factors from one route of exposure to another can be
misleading. If"adequate data.are available on carcinogenicity by oral, inhal-
ation, and dermal exposure it seems most reasonable to derive separate potency
factors for each route. Subsequent selection of the potency factor associated
with the most sensitive route of exposure is then used to complete the overall
hazard ran&ng process.
B-32
-------
4. SM4ABI OF CABCXNOGEHIC HAZARD RA5X2NG
The results of the qualitative and quantitative assessment Tor each of
the substances included in this study are summarized in the accompanying
table. For more detailed discussion, specific data, and references to the
scientific literature, the reader is referred to the Appendix which contains a
corresponding profile for each of the chemicals covered in the table.
B-33
-------
5. REFERENCES
Cox, C.R. 1972. Regression model and life tables. J. Roy. Stat. Soc. 3.
3^: 187.
Croup, K.S. 1980. An improved procedure for low-dose carcinogenic risk
assessment frcm animal data. J. Environ. Pathol. Toxicol.
Crunp, K.S., H.A. Guess and fC.L. Deal. 1977. Confidence intervals and tests
of hypotheses concerning dose-response relations inferred for animal carcino-
genicity data. Biometrics. 33: 437-451.
Doll, R. 1971. Weibull distribution of cancer: Implications for models of
carcinogenesis. J. Roy. Stat. Soc. A. 13: 133.
IARC (International Agency for Research on Cancer). 1979. IARC Monographs on
the Evaluation of the Carcinogenic Risk of Chemicals to Humana. Chemicals and
Industrial Processes Associated With Cancer in Humans. IARC Monograph Supple-
ment 1. Lyon, France, September 1979.
U.S. EPA. 1976. "Interim Procedures and Guidelines for Health Risk and
Economic Impact Assessments of Suspected Carcinogens." Federal Register 41
(May'25, 1976): 21402.
B-34
-------
U.S. EPA. 1980. "Guidelines and Methodology for the Preparation of Health
Effects Assessment Chapters of the Ambient Water Quality Criteria Docunents,"
Federal Register 45 (November 28, 1980): 79347.
B-35
-------
Siuanary Table of llaurd Ranking Tor Reportable Quantities under CEHU.A
Chemical Homo
Chenloal
(CAS)
Degree of Evidence
lluaana Inluala
Grouping Based
on UDC Criteria
Potency Factor
Estimate
Potenoy
Group
Hazard
Hanking
Icenaphtliene
(81-32-91
Inadequate
Inadequate
3
UK
HI
b
icenaphtliylene
(206-96-8)
Inadequate
Inadequate
3
Hi
Nt
b
2-lcetylanlnofluorene
(53-96-3)
Inadequate
Sufficient
2B
32.00
2
Hedlua
icrylonltrlle
(107-13-1)
Halted
Sufflolent
21
0.06
H
Lou
Aflutoxln Bj
(1162-65-8)
L Lulled
Surrielcnt
21
10,000.00
1
High
ildrln
(309-00-2)
Inadequate
Llaited
2B
63.00
2
Hedlua
4-1 nl nobl phenyl
(92-67-1)
Sufficient
Sufriolent
1
67.00
2
High
inltrole ,
(61-62-5)
Inadequate
Sufficient
28
9.20
3
Low
touon 1 iu blchroaale
(7769-09-5)
Inadequate
Inadequate
lB
e
HI
Kedl is
lunonlin chroaate
(7768-98-9)
Inadequate
Inadequate
is
e
HI
Hedlua
lutliractine
(120-12-7)
Inadequate
Inadequate
3
HI
Hi
b
Araenlo antl Ccupounda
(71HO-38-2)
Sufriolent
Inadequate
1
130.00
HI
High
iraenlo sold
(7778-39-11
Ltailed
Inadequate
24d
d
HA
lllgh
iraenlo disulfide
(1301-32-8)
Llnlted
Inadequate
4
HI
High
Iracnlo trichloride
(7/01-3H-I)
Malted
Inadequate
2id
d
Hi
High
Mole. The ildtd herein without additional analysis should not* be used for risk assessment purposes.
-------
Summary Table of Hazard Ranking Tor Re|>or table Quantities under CERU.A (Cunt.)
Cliealcal Decree of Evidence Orouplng Baaed Potenoy Factor Potenoy Hazard
Cliealcal Name (CAS) lluoana Inlaalg on IARC Criteria Eatlnale Group Ranking
Araenlo pentoilde
( 1303-28-2)
Limited
Inadequate
2 Ad
d
HI
II lull
Araenlo trloxldo
(1327-53-3)
Sufficient
Inadequate
1
130.00
1
lllgli
iraenlo trlaulflde
(130 3-33-9)
Llalted
Inadequate
2Ad
d
HI
III fit"
Aabeatoa
(I332-2I-H)
Sufficient
Sufficient
1
P
P
P
Auraalne
(2*165-27-2)
Inadequate
Sufficient
2B
1.20
3
Low
luaerlnt
(115-02-6)
Inadequate
Sufficient
2B
a
HI
0
Azlrldlne
(151-56-t)
Inadequate
Llalted
2B
310.00
1
II lull
Benzene
(71-13-2)
Sufficient
Llalted
1
0.26
*
Low
Benzidine and lis salts
(92-87-5)
Sufflolent
Sufflolent
1
1.90
3
Hedlua
1 Benzof a ]pyrene
I
(50-32-8)
Inadequate
Sufflolent
2B
500.00
1
High
' Benzo(b]fluoranthene
(205-99-2)
Inadequate
Sufflolent
2b
150.001
1
lllgh
Benzo[g)il ]perylcne
(191-21-2)
Inadequate
Inadequate
3
Hi
HA
b
Benzo[ k )f 1 uorant hene
(207-08-9)
Inadequate
Llalted
3r
HI
NA
0
Benzyl Chloride
(IOO-im-7)
Inadequate
Llalted
3r
Hi
NA
o
llt>iiz[a Jantliracena
(56-55-3)
Inadequate
Sufflolent
2B
21.00
2
Hedlurn
Note: The data herein without additional analysis should nat be used for risk assessment purposes.
-------
Suanary Table of Hazard Ranking for Reportable Quantities under CERO.I (Cont.)
Chemical Degree of Evidence Grouping Based Potenoy Faolor Potency Hazard
Chemical Rase (CAS) lluoana inloals on 11RC Criteria eatlnate Group Ranking
Bem[ o Jaorl dine
(225-51-*)
Inadequate
Llalted
3r
1500.00
t
Heilluo
Uerylllin and Cod pounds
Llalted
Inadequate
2ld
d
Hi
lllgh
CuJclia arsonlie
(527^0-16-6)
Llalted
Inadequate
2ld
d
HI
111 B)i
Calclua clirouale
(13765-19-0)
Sufficient
Sufficient
1®
B
Hi
Hedl in
Carbon tetraohlorlde
(5^-23-5)
Inadequate
Sufflolent
2B
39.00
2
Hedlua
CliloruaUioll
(305-03-3)
Sufficient
Sufflolent
1
a
Hi
o
Note: The da La herein
without additional analysts should not be used
for risk
assessment purposes
%
-------
Summary Table of Hazard Ranking Tor fieportable Quantities under CERCLA (Cont.)
Ctieatcot Nana
Client cat
(CIS)
Degree of
llmans
Evidence
Anlsals
Orouplng Baaed
on liRC Crlterla
Potency Paotor
Estimate
Potency
Group
Hazard
Ranking
Chlordano
(57-7*-9)
Inadequate
Llalted
3P
83.00
2
Low
Ctilornaptiaxtne
(>l9l*-03-1>
Sufriolenl
Llalted
t
¦
na
o
Clilorobenzllate
(510-15-6)
Inadequate
Sufflatent
2B
1.60
3
Lou
Clilorofona
(67-66-1)
Inadequate
Sufficient
2B
2.00
3
Low
Chloroaethyl aelhyl etlier
(tecluilcal greda)"
(107-30-2)
Sufficient"
Sufficient"
1
n
n
lllglin
CliloroneLhyl Methyl etliar
(107-30-2)
Inadequate
Inadequate
3
NA
NA
b
ll-Cliloro-o-tol uldlne
liydrocliiorldo
(3165-93-3)
Inadequate
Surriolent
2B
0.07
4
Low
Cliroalun and Compounds
<71Ho-*7-3)
Llalted
Inadequate
1S
1.90®
3
Hedlua
Ctiroalo acetate
(1066-30-*)
Inadequate
Inadequate
Is
S
NA
b
Cliromlo Bold
(7738-9H-5)
Llalted
Inadequate
1*
t
NA
Hedlua
Citron 1 a aulTale
(ldlOl-53-0)
Inadequate
Inadequate
ft
>
MA
b
Cliroaoiu aold
(IDOI19-05-5)
Inadequate
Inadequate
a
IU
b
Cliryaene
(216-01-9)
Inadequate
Sufflolent
2B
5.001
3
Low
Creosote
(0001-58-9)
Limited
Sufficient
21
58.00
2
Hedlua
Cuprlo acetoaraenlte
(12002-03-8)
Inadequate
lnadeqi late
2»d
d
NA
High
Hole; Tito data here 111 without additional analysis should not he used for risk assessment purposes.
-------
Summary Table of Hazard Ranking for Reportable Quantities under CEflCLk (Coot.)
Chemical Degree of Evidence Grouping Oaaed Potency Factor Potency Hazard
Clittolcal Name (CIS) llusana Anlnala on IAHC Criteria Eatleate Group Ranking
C ycl Oflioa ptiaa 1 de
(50-18-0)
Sufficient
Sufficient
1
IB. 00
2
High
Damiocyoln
(?08}0-B1-J)
Inadequate
Sufficient
2B
•
HA
o
DllO
(72-54-B)
Inadequate
Sufficient
2B
0.10
4
Low
DDE
U2-55-9)
Inadequate
Sufflolent
28
3.60
3
Low
DDT
(50-29-3)
Inadequate
Sufficient
2B
5.60
3
Lou
Dlallate
(2303-16-4)
Inadequate
Sufflolent
2B
2.1)0
3
Low
2,4-Dlaalnotoluene
(95-00-7)
inadequate
Sufflolent
2B
3.00
3
Low
1,2,7,0-Dibenzopyrene
(IB9-55-9)
inadequate
Sufficient
2B
a
N*
a
DlU>ux[a,h Jantliraceno
(53-70-3)
inadequate
Sufflolent
28
1000.00
1
High
1,2-1) 1 bromo- 3-clil oropropane
(96-12-6)
Inadequate
Sufficient
2B
170.00
1
High
Dibit ylnl I ros amine
(924-16-3)
Inadequate
Sufflolent
2B
34.00
Hedlua
3,3'-Dicl))oro benzidine
(91-91-1)
Inadequate
Sufficient
2B
7.10
3
Low
1,2-Dlchl oroetliane
(107-06-2)
Inadequate
Sufficient
2B
0.23
4
Low
1,1-Dlcliloroetliylene
(75-35—*1)
inadequate
United
3r
4.60
3
Low
Dlcliloroplienyl ural ne
(696-28-6)
Inadequate
Inadequate
3
Hi
HA
b
Hole: The data herein without additional analysis should not he used for risk assessment purposes.
-------
Siimadry Table of llaurd Banking for Reportable Quantities under CEHQ.H (Cont.)
Cheolcal Degree of Evidence Grouping Baaed Potency factor Potenoy Hazard
Cliimlcal Home (CIS) lliuiiiis inlnula on IlflC Criteria Eatlaiate Group Banking
Dloldrln (60-57-1)
Dlepoiybutane ( 11611-53-5)
Dletlkanolnltroaaalne C 1116-5*1—7>
Diethyl trains <692-U2—2|
1,2-Dlelhyltiydrazlne (161S-80-1)
Dtcthylnltroaamlna (55-18-5)
Olattiylatllbdatrol (56-53-1)
D1hydrosafrolo (9*1-56-6)
Id 3,)*-DlaeLhoiybenzidln« (119-90-1)
I
H-* Dloethyl sulfate (77-70-1)
Dlaelhyluuilnoazobenzena (60-11-7)
7, IZ-Dteattiylbanzfa] (57-97-6)
• albruouiie
Dimethylcarbamoyl chloride (79-N"I —7J
I, l-Dlaethylhydrazine (57 — 1 %—^ )
1,2-Dlaethylhydrazine (5MO-73-B)
Inadequate
Inadequate
Inadequate
Inadequate
Inadequate
Inadequate
SufMol ent
Inadequate
Inadequate
Inadequate
Inadequate
Inadequate
Sufficient
Sufficient
Sufficient
Inadequate
Sufficient
Sufficient
Sufficient
Sufficient
Sufficient
Sufficient
Surflatent
Sufficient
Inadequate Sufficient
Inadequate Sufficient
Inadequate Sufficient
ZB
2B
2B
3
2B
2B
t
2U
2B
2B
2B
2B
2B
2B
2B
130.00
a.50
17.00
N*
«
1000.00
7900.00
1.10
0.01
•
260.00
200,000.00
510.00
13.00
67O.OO
1
3
2
HI
N
lllgh
Lou
Hedlua
b
o
High
lllgh
Low
Low
o
High
High
lllgh
Hedltu
lllgh
Mote: The data herein without additional analysis should not be used for risk assessment purposes.
-------
Summary Table of Hazard Ranking for Deportabl e~QtianlI tl ea uidor CtNCI.A (Conl.)
Client cat Mmis
Clinical
(CIS)
Degree of
llttsuna
Evidence
inlaala
Grouping based
on URC Criteria
potenoy fiotor
CtlllilU
Potency
Group
Hazard
Ranking
DlneLlijflnl Iroafuolna
(42-75-9)
Inadequate
Sufficient
2tt
29.00
2
Hedlua
2,3-1)1 nl Lrotol uene
(602-01-7)
Inadequate
Inadequate
3
kl
H*
ti
2, N-Dlnltrotul uone
1121-1*1-2)
Inadequate
Sufficient
2B
3.BO
3
Low
2,J-MnltroUlu:n«
(619-15-6)
Inadequate
Inadequate
3
m
Hi
b
2,6-Dinl Irotcl uuna
(6(16-20-2)
Inadequate
LlaUad
Jr
nil
M
0
3,
Ethylene dtbroalde
(106-93-4)
Jnadeqi'«tc
Sufflotent
2B
13.00
2
Hedl in
Ethylene Oxide
(75-21-fl)
Llolled
Llslted
21
6.00
3
Hedlun
E ttiyl eiiet hi ourea
(96*15-7)
Inadequate
Suf rialcnl
2B
0.97
4
Low
Note: The data herein without additional analysis should not be used for risk assessment purposes.
-------
Summary Table or Hazard Hanking for Reportable Quantities under CEHCLA (Cont.)
Chemical Naaa
Clienleal
(CAS)
Degree of Evidence
Nucana inlnala
Grouping Baaed
on IHC Crl terla
Potency Factor
Eetlauto
Potency
Group
Hazard
Han king
1-Etliyl-l-nl trosourea
(759-73-9)
Inadequate
Sufficient
2B
A.70
3
Lou
Ferrlo dextran
(900«l-66-*)
Inadequate
Sufflolent
2B
0
HA
b
fluoranthene
(2O6-H1-0)
Inadequate
Inadequate
3
Hi
N*
b
Fluorena
(B6-73-7)
Inadequate
Inadequate
3
HI
HA
b
01 yo i da I dehyde
(765-3*-%)
Inadequate
Sufflolent
20
1.20
3
Hedlua
llejitachlor
(76-114-8)
Inadequate
Sufflolent
2B
36.00
Z
Hedlun
lleplaohlor Epoxide
(1021-57-3)
Inadequate
Sufflolent
2B
36.00*
2
Hedlua
llaiachlorobenxtine
(118-71-1)
Inadequate
Sufflolent
2B
(2.00
2
Hedlui
lleiaohlorobutadi ene
(67-66-3)
Inadequate
Llalted
3r
0.50
1
Low
a-lleiaohl or-ocyol olie xane
OI9-81-61
Inadequate
Sufflolent
2B
211.00
1
111 eii
0-llexacJiloroayalotieune
<3l9-65-Tl
Inadequate
Llalted
3r
1.70
3
Low
H-H a xactil orocya lolie xaue
(5&-B9-9)
Inadequate
Malted
2B
1.70
3
Low
4-II a *adt 1 or oc y o I ohe xane
(319-66-8)
Inadequate
Inadequate
3
Nl
Nk
It
lleiaohloroelliana
(67-12-1)
Inadequate
Llalted
3r
0.27
¦I
Low
Hydrazine
(302-01-1)
Inadequate
Sufflolent
2B
100.00
1
High
Note: The data herein without additional analysis should not be used for risk assessment purposes.
-------
Summary Table of Hazard Ranking for Reportable Quantities
under CERCI.A (Coul
.)
Client eel Niuse
Chemical
(CAS)
Degree of Evidence Grouping Baaed
IIksuna Anlaale on HRC Criteria
Potency factor
Eatlsate
Potency
Group
Hazard
Nanking
I ndtmo (1,2, J-od )pyrene
(193-39-5)
Inadequate
Llalted
2B
¦
NA
a
laduaethane
(77-88-*)
Inadequate
Llalted
3r
KA
HA
o
Iaosafrole
(120-58-1)
Inadequate
Llet ted
3r
0.51
1
Lou
K«|>one
(113-50-0)
Inadequate
Sufficient
28
11.00
2
Medium
Lulocarplne
(303-31-1)
Inadequate
Sufficient
2B
38.00
2
Hedlus
Lead acetate
(301-0)1-2)
Inadequate
Sufflolent
2B
7.30
3
Lou
*
Lead arsenate
(3681-31-6)
Llalted
Inadequate
2Ad
«l
MA
ill eh
Load ptioaphate
(7116-27-7)
Inadequate
L lotted
2 B
a
NA
a
Lead aubaoetate
(1335-32-4)
Inadequate
Sufflolent
2B
0.17
1
Low
L11 hi in etironale
(11307-35-8)
Inadequate
Inadequate
1*
s
NA
Hedlun
3-Helliylctiol anthrane
(56-19-3)
Inadequate
Sufficient
2B
12.00
3
Hedlia
1, 1 • -Hethy 1 cue - bl s-
(Z-cliloroan 111 lie )
(10I-U-4)
Inadequate
Sufflolent
2B
1.70
3
Lou
Ht>L liyl nJ troaourea
(681-93-5)
Inadequate
Sufficient
20
12,000.00
1
High
Hoi liyl llil our ac 11
(56-01-2)
Inadequate
Sufflolent
2B
30.00
2
Hedlua
Hettiylvlnylul troaanln#
(15t(9-10-0)
Inadequate
Sufflclent
2B
ft
HA
o
Hote: The data herein without additional analysis should not be used for risk assessment purposes,
-------
Summary Table or Hazard Hanking for Reportable Quantities imder CtHQ.l (Cont.)
Chcatcal Degroo of Evidence Orouplng Based Potenoy Factor Potenoy Hazard
Chemical Home (CIS) llmaiia Anloalo on IARC Criteria Eatlaato Group Hunklitg
N-Melhyl-H'-ultro-H-
nltroaoguanldlne
(70-25-7)
Inadequate
Sufficient
2D
58.00
2
Hedlurn
Hltoayoln C
(50-07-7)
Inadequate
Sufflolent
2B
a
Hi
o
Huitird gaa
(505-60-2)
Sufficient
Llalted
1
a
HI
0
1-Naphtliylaalna
< 131-32-7)
Inadequate
Llalted
3r
HA
ta
0
2-Haptitliylsalne
(91-59-8)
Surriclent
Sufflolent
1
5.20
3
Hedlua
Nlokel and Ctnpounda
(71(110-02-0)
Llalted
Sufflolenl
21h
I.101
3
Hedlua
Hlckel luonlui Sulfate
(15699-18-0)
Limited
Llalted
2»h
1
Hi
Hedlin
Hlokel carbonyl
(13t63-39-3)
Limited
Sufflolent
2Ah
I
111
Hedlum
Hlckal olilorlde
(7718-5(1-9)
LUlled
Llalted
2jh
1
Nft
Hedlua
Hlckel oyanlde
(557-19-7)
Llalted
Llalted
2ih
I
Ml
Hedlua
Hlckal hydroxide
(12054-NB-7)
Llalted
Llalted
2»h
1
Ml
Hedlua
Hlckel nltrato
(13478-00-7)
Llalted
Llalted
2lh
1
HI
Hedl ua
Hlckal subaulflde
(12035-72-2)
Llalted
Sufflolant
24h
1.10*
1
Hedl ua
Nickel sulfate
< 77B6-A1-"*)
LlslLed
Llalted
21h
1
HA
Hedl ua
Hltroaoaethyliirethane
(615-53-2)
Inadequate
Sufflolent
2B
2*100.00
1
lllgh
Note: The data herein without additional analysts should not be used for risk assessment purposes.
-------
Siuaodry Tattle pf Hazard Ranking Tor Reportable Quantities under CKHQ-i Itont.)
Cliealcel Nubs
Ctiealcal
(CIS)
l>cgree of Evidence
lliuans InlBdla
Grouping liased
on ItIIC Criteria
poienoy Factor
Estimate
PoLcncy
Group
Hazard
Hankl ng
N-NUroaoplporldlnb
doo-15-m
Inadequate
Sufficient
2D
170.00
1
llleti
H-Hltraaopyrrol Idlcie
(930-55-21
I uadequat e
Sufflol ent
20
290.00
1
nie>>
5-Hltro-o-tol uldlne
(99-55-B)
Inadequate
Llalted
3r
0.53
4
Low
Peiitacliloronl Irobentene
(62-68-6)
Inadequate
Limited
3r
1.50
3
Lou
Plienacetln
(62-V1-2)
Inadequate
Sufficient
2B
0.02
«
Low
Flien&fit lirene
(05-01-S»
inadequate
Inadequate
3
HA
KA
b
Plienol»art>l la)
(50-06-6)
Inadequate
Llnlted
3r
0.75
H
Low
Phenylalanine Huslard
(1*8-82-3)
Sufficient
Sufflol ent
1
1100.00
1
lllB>>
Pol yolilorl rtated bl phenyl a
(1336-36-3)
Inadequate
Sufficient
2B
37.00"
Hedl ua
Potualua arsenate
(77e«J-«i »-o>
Llnlted
Inadequate
2k*
d
Ni
111 6ti
PoLualin araenlte
(I012U-50-2)
Llalted
Inadequate
Zk*
d
Ni
lllBh
PatualiB liiclirouaLa
(1776-50-9)
Llalted
Inadequate
1«
s
HA
Kedl uu
Potualua chronate
(7789-00-6)
Llnlted
Inadequate
1«
8
Hi
Hedl us
Propana eultone
(1120-7 »-*)
Inadequate
Sufflolent
2B
37.00
2
Kedl ua
Propyl enlal ne
(75-55-B)
Inadequate
Sufficient
2B
15.00
2
Hedl urn
Hole: The data herein without additional analysts should not be used for risk assessment purposes.
-------
Summary Table of Hazard Ranking for R«n>or table Quantities uitdor CttlCLA (Cont.)
CIimIcjI Degree of Evidence Orou|>lng flaaed Potency Factor Polenoy Hazard
Cliealcal Hame (CIS) lliaaana Anlaala on IAHC Criteria EallnaLe Gi oup Ranking
Pyrene
(129-00-0)
Inadequate
Inadequate
3
NA
UA
b
Saccharin
(81-07-2)
Inadequate
L 1ml ted
3r
0.01
>1
Low
Safrole
(91-59-7)
Inadequate
Sufftalent
2B
0.20
4
Low
Sod1 in arsenate
(7631-89-2)
Llulled
Inadequate
2Ad
d
HA
Hedluo
Sodlua araenlte
(7781-16-5)
Llet ted
Inadequate
2Ad
d
NA
Medlua
Sodlin blchronale
(I05BB-0I-9)
Limited
Inadequate
1«
8
HA
Medlus
Sodlin citron ate
(7T75-U-3)
Llolled
Inadequate
1B
8
NA
Hedlua
Streptozotocln
(18683-66-4)
Inadequate
Sufficient
2B
110.00
1
lllgh
Strontium cliroaate
(7789-06-2)
Inadequate
Inadequate
1g
8
NA
Medlua
1 2,3,7,8-Tatrachloro-
dlbenzo-p-dloiln
(1746-01-6)
Inadequate
Sufficient
2B
120,000.00
1
High
1,1,1,2-TetracMoroethane
(630-20-6)
Inadequate
Inadequate
3
NA
NA
b
1,1,2,2-Telrocliloroathane
(79-3H-5)
Inadequate
Malted
3r
1.70
t
Low
Tetracliloroelhy 1 ene
(121-16-41)
1 inadequate
Llulled
3r
0.18
Lou
Tliloacetaalde
(62-55-5)
Inadequate
Sufficient
2B
27.00
2
Medina
Thiourea
(62-56-6)
Inadequate
Sufficient
2B
B0.00
2
Medl in
Note: Ttie data herein without additional analysis should not be used for risk assessment purposes.
-------
Summary Table of Hazard Ranking for Reportable Quantities under C£RCLA (Cont.)
Cheolcal Name
Cbeolcal
(CAS)
Degree of
llinana
Evidence
Anlaala
drouplng Baaed
on IAf)C Criteria
Potency Paotol*
Catlaate
Potency
Group
Hazard
Hanking
O-Tol ldl ne
(119-93-7)
Inadequate
Sufficient
2B
27.00
2
Medlin
O-Tolutdlna and
Ita hydrochloride
(636-21-5)
Llalted
Sufficient
2A
0.22
H
Low
Toxaphene
(6001-35-2)
Inadequate
Sufficient
2B
9.70
3
Low
1, 1,2-Trlchloroothane
(79-00-5)
Inadequate
LUtted
3r
0.30
<1
Low
Trlchloroethylene
(79-01-6)
Inadequate
Llalted
3r
0.18
H
Low
2, N,6-Trlchloro phenol
(68-06-2)
Inadequate
Sufficient
2B
O.OB
4
Low
Trlo(2,3-dl broaopropyl )
phoa pliate
(126-72-7)
Inadequate
Sufficient
2B
9.60
3
Low
Trypan blue
(72-57-1)
Inadequate
Sufficient
2B
0.01
Low
Uracil Huatard
(66-75-1)
Inadequate
Sufficient
2B
e
Hi
o
Uretliaiio
(51-79-6)
Inadequate
Sufficient
2B
0.6<)
4
Low
Vinyl chloride
(75-01-1))
Sufficient
Sufficient
1
0.16
4
Low
Note: The data herein without additional analysis should not be used for risk assessment purposes.
-------
Summary Table of Hazard Ranking for Reportable Quantities under CERU.A (Cont.)
Chemical Degree of Evidence Orouplng Baaed Potenoy Factor Potency Hazard
Chen leal Name (CAS) Humans Inlula on ItRC Criteria Estlaato Group Ranking
aData available are Inadequate for calculation of potency faotor using ourrent Methodology. |n appropriate aethod or estimating a potenoy faotor for
these types or data Is ourrently under developaent by CAO.
bOther toilolty endpoints sust be used as a basis for hazard ranking.
"Carcinogen hazard ranking will be possible when methodology to oalculata a reasonable potenoy faotor la developed or new data becomes available.
Grouping and potenoy faotor estimate Is based on weight of evldenoe for araenlo and arsenlo aoapounds In the drinking water of huaana (assuaed to be
predominantly the trloxlde).
^Grouping la based on weight of evidence for beryl I Im sulfate.
Grouping la based on weight of evldenoe for c a da1 in compounds as I olaaa.
^Grouping la baaed on weight of evldenoe for ohroaate produotlon and anlaal data which Indicates that heiavalent chroalua la oarolnogenlo. The
potenoy estimate la based on epldeneology data for total oliroalua eiposure of ohroaata workers..
Grouping la based on weight of evldenoe for nickel compounds as a olasa.
'caloulated, using tho potenoy faotor estlaata for benso[a Ipyrena as a referonoe.
^Potenoy estimate la based on data frum berylllua sulfate eipoauro In rata.
L
Potenoy estimate la based on epldeaeology data'for oadalua smelters. Please nota that potency estlaato based on anlaal data would ba at least 100
times higher. Please refer to OIIEA document "Addendum to the Health Aasessaent Document for Cadalua, 1983" for details.
^Potency estimate la based on data for nlolcel aubsulflde.
"potenoy estimate la based on data for Aroolor 1260.
"Technloal grade oliloroaethyl methyl ether la contaminated with bla(ohloroaothyl )ether, and tho hazard ranking la therefore baaed on the evidence for
blsfolilorooethyl )ether.
inappropriate to group or rank for environmental considerations beoauaa available evidence la based on auboutaneoua and Intraauscular Injeotlon
eiperlments.
PA potency factor estlaate for asbestos la Inappropriate here because the oarolnogenlo potential of asbeatoa la related to apeolflo fiber shapes,
sizes, and atinospherla concentrations. Ilr concentrations are usually aeasured either as nuaber of fibers or aaas. However, no dlreat relationship
exists between air fiber/ml (>5 microns) concentrations (by the phase contrast light microscope acthod) and aaas concentrations In |ig/a' (determined
by electron oloroscopy). The relationship depends on the typo of anvlronaent sampled, tho type of asbestos In the air, and the alee of the fibers.
^Potency factor estimate Is baaed on data for heptaahlor alnoe heptaohlor epoxide la a metabolite of heptaohlor.
rThe Oroup 3 oategory Includes chemicals for which the evidence froa anlaal studies la Halted or Inadequate and there la no hioan evldenoe. These
are group 3 chemicals with Halted anlaal evidence, for tltose with good dose-related data, a potenoy estlaate Is determined and a hazard ranking la
performed.
Compounds with group 1 potenoy factor estlaates (>100) are given "aedlui" hazard ranking. Coapounda In potency group 2,3 or 4 are given
¦low" hazard rankings.
HA = Not applicable
-------
Summary Table of Hazard Banking for Reportable Quantities under CERC1.* (Cont.)
Cliemlcal Degree or Evidence Grouping baaed Potenoy Faotor Potenoy Hazard
Chemloal Name (CAS) Humana Anlaala on 1AHC Criteria Estlaate Qroup Ranking
aOata available are Inadequate for calculation or potency faotor using current aethodology. in appropriate Method of estimating ¦ potency factor for
these types of data Is ourrently under develofnent by Clfl.
''other toxlolty endpolnts aust be used as a basis for hazard ranking.
"carcinogen hazard ranking will bu possible uhen aethodology to calculate m reasonable potenoy factor la developed or new data beoomes available.
Grouping and potenoy factor estlaate Is based on weight of evldenoe for araenlo and arsenla canpounds In the drinking water of humans (asauned to be
predoalnantly the trloxlde).
o
Grouping la based on weight of evidence for berylllut auli'ate.
^Grouping Is based on weight of evidence for oadalua compounds as a olass.
'Grouping Is based on weight of evldenoe for ohroaate produotlon and anlaal data which lndloates that hexavalent chroalia la oarolnogenlo. The
potenoy estlaate la based on epldoaeology data for total chroalus exposure of ohroaate workers..
Grouping la based on weight of evldenoe for nickel coapounds as a atasa.
^Calculated, using the potenoy faotor estimate for benzo[aJpyrene as a referenoe.
^Potenoy estlaate la based on data froa berylllua sulfate eipoaure In rata.
Potenoy estlaate la based on epldeaeology data'for cadalm aaeltera. Please note that potency eatlaato baaed on anlaal data would bo at least 100
tlaes higher. Pleaao refer to OIIEA doouaent "Addendum to the Health Assessaent Doauaent for Cadalua, 1983" for details.
'potency estlaate la baaed on data for nlokel aubsulflda.
"potenoy estlaate la baaed on data for Aroolor 1260.
technical grade oliloroaethyl aethyl ether la contaminated with blafohloroaethylJether, and the hazard ranking la therefore based on the evidence for
bls(ohloronethyl )ether.
o
Inappropriate to group or rank for environmental considerations because available evldenoe la baaed on aubcutanaoua and Intraauscular Injection
experiments.
p
I potenoy factor estlaate for asbestos Is inappropriate here because the oarolnogenlo potential of asbestos la related to apeolflo fiber ahapes,
at tea, and ataosplierlo concentrations. Air concentrations are usually aeaaured either as nuaber of fibers or aass. However, no direct relationship
exists between air fiber/at (>5 alorona) concentrations (by the phase contrast light alaroscope aethod) and aass concentrations In |ig/a* (determined
by electron microscopy). The relationship depends on the type of environment aaapled, the type of asbestos In the air, and the alze of the fibers.
''potenoy factor estlaate Is based on data for heptaolilor since heptaohlor epoxide la a metabolite of heptachlor.
|»
Tlie Oroup 3 oalegory Includes ohealoals for which the evidence frca animal studies la Halted or Inadequate and thero la no huaan evldenoe. These
•re group 3 ohealoals with Halted animal evidence. For tiiose with good dose-related data, a potency estimate la determined and a hazard ranking Is
performed.
Compounds with group 1 potenoy factor estimates (>|00) are gl-ven "nedlm" hazard ranking. Ccapounds In potency group 2,3 or 4 are given
"low" hazard rankings.
Ut = Hot applicable
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Appendix C
SUMMARY TABLE FOR THE RANKING
OF FORMALDEHYDE, 2-NITROPROPANE, SELENIUM SULFIDE,
BENZOTRICHLORIDE, AND BIS(2-ETHYLHEXYL) PHTHALATE
BASED ON CARCINOGENICITY
C-l
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1*0 Sr4.
^ \
'4C PI»0"tV
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
WAShiNo iON D C 20450
FeDruary 8, 1985
office cr
RESEARCH AND DEVELOPMENT
SUBJECT: Ranking of Five Chemicals Based on August Methodology Developed
in the July 1983 Draft OHEA Document (0HEA-C-073)
Attached is a summary table for the ranking of the five chemicals you
requested for a carcinogenic hazard ranking. The ranking should be used and
read in the same context as stated in the July 1983 Office of Health and
Environmental Assessment draft document titled "Technical Support Document
and Summary Table for the Ranking of Hazardous Chemicals Based on
Carcinogenicity".
Attachment
FROM:
FROM:
Carcinogen Assessment Group (RD-689)
TO: Jack Kooyoomjian
Environmental Engineer
Emergency Response Division (WH-548B)
THRU: Robert E. McGaughy ^ ' \ 11 - « r ,
Acting Technical Director
Carcinogen Assessment Group (RD-689)
C-2
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Chemical Name CAS#
Degree of
Humans
Evidence
Animals
Grouping
Based on
IARC Criteria
Potency
Factor
Estimate
Potency
Group
Hazard
Ranking
RQ
Formaldehyde (50000)
I
S
2B
2
3
Low
100
2 Nitropropane (79469)
I
S
2B
0.14
4
Low
100
Selenium (7488564)
Sulfide
I
S
2B
0.15
4
Low
100
Benzotrichloride
(98077)
L
S
2A
3.5
3
Medium
10
Bis (2-ethylhexyl)
phthalate (117817)
I
S
2B
0.002
4
Low
100
NOTE: The data herein without additional analysis should not be
used for risk assessment purposes.
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