* r is_a \ Y*; f - X It*'' r* ;* Vi life y -v. *r j>A„. Environmental Cancer and Heart and Lung Disease Tenth Report to Congress 1987/88 TASiC FORCE ON ENVIRONMENTAL CANCER AND HEART AND LUNG DISEASE •S f ------- Qc-C c..P /lA £<-(> ¦ ?>. U. SV 3 mvJsZ Environmental Cancer and Heart and Lung Disease Tenth Report to Congress 1987/88 Thsk Force on Environmental Cancer and Heart and Lung Disease U.S. Environmental Protection Agency Public Health Service National Institutes of Health National Cancer Institute National Heart, Lung, and Blood Institute National Institute of Environmental Health Sciences Centers for Disease Control National Institute for Occupational Safety and Health National Center for Health Statistics Food and Drug Administration Agency for Tbxic Substances and Disease Registry Department of Energy Consumer Product Safety Commission Occupational Safety and Health Administration Department of Agriculture Department of Defense Veterans Administation S3 m 283 ill 3>s o m co • > 33 o Prepared by the Ibsk Force Working Group Ken Sexton, Chairperson ------- Copies of this document may be obtained free of charge through requests to Office of Health Research (RD-683) U.S. Environmental Protection Agency 401 M Street, SW Washington, DC 204B0 (202) 382-5895 When this supply is exhausted, the document can be purchased from National Technical Information Service U.S. Department of Commerce 5285 Port Royal Road Springfield, Virginia 22161 ------- TASK FORCE ON ENVIRONMENTAL CANCER AND HEART AND LUNG DISEASE Please address your reply lo APR 6 1989 William K. Reilly Administrator U.S. Environmental Protection Agency 401 M Street, SW Washington, DC 20460 Honorable j. Danforth Quayle President of the Senate Washington, DC 20510 Dear Mr. President: As Chairman of the Task Force on Environmental Cancer and Heart and Lung Disease, 1 am pleased to submit the Tenth Report to Congress in accordance with Public Law 95-95, Section 402 (b)(5). The 15 Agencies that constitute the Task Force continue to work together to assess possible relationships between environmental pollutants and human health. The report describes Task Force activities, including a major workshop on risk communication and public education, the publication of the report of its workshop on health professional education, and initiation of planning for workshops on the effects of pesticides on human health and evaluation of risk communication programs. This report includes three recommendations based on the conclusions of participants in the Workshop on the Role of Government in Health Risk Communication and Public Education. The recommendations call for sharing of risk information among Agencies, the establishment of a national research agenda on risk communication, and the development of risk information specific to community needs. Implicit in these recommendations is the recognition that the goal of risk communication is to ensure that the public is informed and involved in decisions that affect their lives and property. The Task Force's activities contribute to improved understanding of environmentally related disease and serve to identify important research needs that should receive emphasis. The collaborative opportunities fostered by the Task Force promote a broadly based and cooperative Federal approach to environmental health. I believe that such an approach offers the best hope for achieving progress irr the protection Environmental Protection Agency • National Cancer Institute National Heart, Lung, and Blood Institute * National Institute for Occupational Safety and Health National Institute of Environmental Health Sciences • National Center for Health Statistics Centers for Disease Control • Food and Drug Administration Department of Energy • Consumer Product Safety Commission Occupational Safety and Health Administration • Department of Agriculture Department of Defense • Veterans Administration Agency for Toxic Substances and Disease Registry Sincprely, William K. Reill William K. Reill Chairman ------- TASK FORCE ON ENVIRONMENTAL CANCER AND HEART AND LUNG DISEASE Please address your reply to: APR 6 1989 William K, Reilly Administrator U.S. Environmenta. Protection Agency 401 M Street, SW Washington, DC 2046C1 Honorable James C. Wright, Jr. Speaker of the House of Representatives Washington, DC 20515 Dear Mr. Speaker: As Chairman of the Task Force on Environmental CanceT and Heart and Lung Disease, 1 am pleased lo submit the Tenth Report to Congress in accordance with Public Law 95-95, Section 402 (b)(5). The 15 Agencies that constitute the Task Force continue to work together to assess possibie relationships between environmental pollutants and human health. The report describes Task force activities, including a major workshop on risk communication and public education, the publication of the report of its workshop on health professional education, and initiation of planning for workshops on the effects of pesticides on human health and evaluation of risk communication programs. This report includes three recommendations based on the conclusions of participants in (he Workshop on the Role of Government in Health Risk Communication and Public Education. The recommendations call for sharing of risk information among Agencies, the establishment of a national research agenda on risk communication, and the development of risk information specific to community needs. Implicit in these recommendations is the recognition that the goal of risk communication is to ensure that the public is informed and involved in decisions that affect their lives and property. The Task Force's activities contribute to improved understanding of environmentally related disease and serve to identify important research needs that should receive ennphasis. The collaborative opportunities fostered by the Task Force promote a broadly based and cooperative Federal approach to environmental health. I believe that such an approach offers the best hope for achieving progress in the protection Environmental Protection Agency • National Cancer Institute National Heart, Lung, and Blood Institute * National Institute for Occupational Safely and Health National Institute of Environmental Health Sciences • National Center for Health Statistics Centers for Disease Control • Food and Drug Administration Department of Energy • Consumer Product Safety Commission Occupational Safely and Health Administration • Department of Agriculture Department of Defense • Veterans Administration Agency for Toxic Substances and Disease Registry Sincerely, William K. Reil Chairman ------- PREFACE The Tksk Force on Environmental Cancer and Heart and Lung Disease is an interagency group established by Congress to promote cooperation and coordination and recommend research to determine and quantify the relationship between environmental factors and hu- man disease. Its efforts are directed toward reducing or preventing en- vironmentally related diseases, in particular, cancer and heart and lung disease, As a result of Task Force consideration and the member Agen- cies' approval, recommendations have evolved from the needs identi- fied by scientists at Task Force-sponsored workshops. Section 402 of Public Law 95-95, the Clean Air Act Amendments of 1977, designated the initial members as the U.S. Environmental Pro- tection Agency (EPA); and from the Public Health Service (PHS) of the Department of Health and Human Services, the National Cancer Insti- tute (NCI), the National Heart, Lung, and Blood Institute (NHLBI), the National Institute of Environmental Health Sciences (NIEHSJ, and the National Institute for Occupational Safety and Health (NIOSH-Cen- ters for Disease Control). Ten other Government organizations have joined the Tksk Force by invitation: four PHS Agencies, the National Center for Health Statistics (NCHS-Centers for Disease Control), other components from the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), and the Agency for Toxic Substances and Disease Registry (ATSDR); the Department of Energy (DOE) in 1983; the Consumer Product Safety Commission (CPSC) and the Department of Agriculture (USDA) in 1984; the Veterans Administration in 1985; and the Occupational Safety and Health Administration (OSHA) of the Department of Labor in 1980. The Department of Defense (DoD) is an observer to the Thsk Force. iii ------- To meet its reporting requirements to Congress, this report de- scribes the accomplishments of the Task Force during 1987/88. Chapter 1 introduces the Task Force and its various subgroups. Chapter 2 de- scribes the substantive activities of the Task Force during 1987/88. Rec- ommendations are contained in Chapter 3. iv ------- CONTENTS Page EXECUTIVE SUMMARY vii Chapter 1 INTRODUCTION 1 Chapter 2 ACTIVITIES OF THE WORKING GROUP 5 IN 1987/88 Public Education and Communication 5 Health Professional Education 7 Effects of Pesticides on Human Health 9 Environmental Epidemiology 10 Chapter 3 RECOMMENDATIONS 11 Risk Communication and Public Education 11 Appendix A SECTION 402 OF PUBLIC LAW 95-95 17 Appendix B MEMBERS OF THE TASK FORCE, WORKING GROUP, AND AD HOC GROUPS 21 Appendix C MISSION STATEMENT OF THE NEW TASK FORCE MEMBER AGENCY: AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY 31 Appendix D SELECTED PUBLICATIONS FROM THE TASK FORCE ON ENVIRONMENTAL CANCER AND HEART AND LUNG DISEASE 37 v ------- EXECUTIVE SUMMARY The Tbsk Force on Environmental Cancer and Heart and Lung Disease reports yearly to Congress. During 1987/88, the Tksk Force sup- ported a major workshop on risk communication and public education, published the report of its 1986 health professional education workshop, and began planning a major workshop on the effects of pesticide on hu- man health. The following recommendations, offered to Congress for its consid- eration, are based on the conclusions and findings developed by partic- ipants at the Workshop on the Role of Government in Health Risk Com- munication and Public Education: 1. Ongoing mechanisms and networks are needed for sharing information among Agencies about risks, risk assessment, risk management, and risk communication, 2. A national agenda should he established for research on risk communication that identifies gaps and sets priorities, 3. Risk information should be specifically tailored in both content and form to the needs of the target public group in particular communities. The Workshop participants recognized the need for Government Agencies to engage in risk communication so that the public can partic- ipate in an informed manner in decisions that affect their lives and prop- erty. The participants also urged a systematic research approach to the study of risk communication. As recommended by the Workshop, the Tbsk Force's Project Group on Public Education and Communication vii ------- was renamed the Interagency Group on Public Education and Commu- nication and expanded to include representatives of all Tksk Force mem- ber Agencies. An editorial committee prepared the proceedings of the Workshop for publication (Plenum Press, in press]. Recognizing that a recurring theme of the January 1987 Workshop related to the importance of incorporating measures of effectiveness into the planning of risk communication programs, the Interagency Group initiated the planning of a workshop on evaluation. A planning committee defined the workshop objective: to provide practical guidance on planning and evaluation as part of implementing environmental and health risk communication programs. In preparation for the June 1988 workshop, papers were commissioned on evaluation methodology and research and the application of methods and theory to programs. The recommendations from that workshop will be included in the Task Force's Eleventh Report to Congress. Another Tksk Force standing committee, the Interagency Education Program Liaison Group (IEPLG), published the Report of the Workshop on the Community as Patient. The report includes recommendations for research and education and implementation strategies relevant to the role of academic occupational and environmental medicine physicians in reducing risks associated with hazardous substances in the commu- nity. Some of the recommendations developed by the Workshop partic- ipants were presented in the Tksk Force's Ninth Annual Report to Con- gress and were used by the Agency for Toxic Substances and Disease Registry in designing its mandated health education program. The IEPLG also initiated the planning of a workshop to examine possible environmental and occupational factors that may be associated with asthma. In cooperation with the National Heart, Lung, and Blood Institute and the National Institute for Occupational Safety and Health, the IEPLG established a workshop steering committee and held an ini- tial planning meeting to define goals and develop a plan for the work- shop. In cooperation with the Agency for Toxic Substances and Disease Registry, the IEPLG began designing an activity to disseminate informa- tion about the National Library of Medicine's TOXNET data system to health professionals. The target audience for this information dissemi- nation project will be primary care practitioners of family, preventive, and internal medicine, and the intent is to reach them through the 1988 meetings of their specialty organizations. viii ------- In response to the concerns of several Federal Agencies and the public, the Task Force initiated the planning of a major workshop to ex- amine the chronic effects of pesticides on human health. A planning committee composed of Federal and extramural scientists met several times to structure the workshop process. Working groups of scientists began drafting papers to assess several toxicological endpoints of pesti- cide exposure (carcinogenicity, developmental toxicity, reproductive tox- icity, neurotoxicity, and immunotoxicity) and to examine the actual hu- man exposure to pesticides through all media. The workshop was sched- uled for May 1988, and its findings, conclusions, and recommendations will be presented in the Task Force's Eleventh Report to Congress. The Long-Range Planning Committee reviewed and revised planned activities, and the Working Group undertook a feasibility study for a pro- posed activity in environmental epidemiology. ix ------- Chapter 1 INTRODUCTION The Task Force on Environmental Cancer and Heart and Lung Disease was established by Congress in the Clean Air Act Amend- ments of 1977 (P.L. 95-95)* to address the environmental disease prob- lem in a broad and coordinated fashion. Congress chose the mecha- nism of an interagency Task Force to ensure continued communication between the U.S. Environmental Protection Agency (EPA), the major regulatory Agency dealing with health and environmental hazards; Agencies conducting health research, particularly the Public Health Service (PHS) Agencies within the Department of Health and Human Services (DHHS); and other Agencies as appropriate. The Tksk Force is mandated to determine and quantify the relationship between envi- ronmental pollution and human disease, in particular, cancer and heart and lung disease, and to recommend research, strategies, and other measures to reduce or eliminate the risk of these diseases and prevent or reduce their incidence, The legislation stipulated that the EPA Administrator or a person designated by the Administrator chair the Task Force and also named the other original members from PHS as the National Cancer Institute (NCI), the National Heart, Lung, and Blood Institute (NHLBI), the Na- tional Institute for Occupational Safety and Health (NIOSH-Centers for Disease Control), and the National Institute of Environmental Health Sciences (NIEHS). The law also specified the involvement of other Agencies with interest in environmental health and, accordingly, the National Center for Health Statistics (NCHS-Centers for Disease Con- trol), other components of the Centers for Disease Control (CDC), the Food and Drug Administration (FDA), the Department of Energy (DOE), the Consumer Product Safety Commission (CPSC), the Department of Agriculture (USDA), the Veterans Administration (VA), and the Agency •See Appendix A for full text of Section 402 (P.L. 95-95). 1 ------- for Toxic Substances and Disease Registry (ATSDR) have become mem- bers. The Department of Defense (DoD) is an observer to the Task Force. The addition of these other Agencies and Departments, by vote of the Task Force, has increased the opportunities to promote and formalize in- teraction and cooperation. The Task Force organization in 1987/88, shown in Figure 1, includ- ed a Plenary, a Working Group, and various ad hoc subgroups charged with conducting specific activities. The Plenary consists of Agency heads and representatives of Departmental Secretaries, who in turn des- ignate the Working Group representatives. The Working Group meets quarterly to discuss environmentally related health problems of national significance that are common to member Agencies. To address these problems, the Working Group identifies research needs through work- shops, symposia, and various ad hoc committees. The members of the Plenary, Working Group, and the subgroups are listed in Appendix B. TASK FORCE ON ENVIRONMENTAL CANCER AND HEART AND LUNG DISEASE •PLANNING COMMITTEE FOB THE WORKSHOP ON THE EFFECTS OF J PESTICIDES ON / HUMAN HEALTH / WORKING GROUP PLENARY INTERAGENCY EDUCATION PROGRAM UAISON GROUP INTERAGENCY GROUP ON PUBLIC EDUCATION AND COMMUNICATION LONG-TERM PLANNING COMMITTEE ' Ad hoc committee nslabliahed for platiniriR !hi- workshop. Figure 1. Ttask Force Organization (1987/88) 2 ------- The Tksk Force workshops bring together the experts in specific subject areas to identify research needs. The workshop reports are pub- lished in the peer-reviewed literature and are available to the entire sci- entific community. The research needs identified by the workshops are submitted to the Working Group, which then conveys the research needs to the Plenary members for their consideration. Some of the research needs are considered by member Agencies in their research planning, and some of these may ultimately become recommendations of the Tksk Force to Congress. The T&sk Force serves to coordinate research and stimulate cooper- ation among Federal Agencies and scientific communities concerned with environmental health. Its members have the opportunity to inte- grate regulatory and research perspectives on the kinds of scientific in- formation needed to provide an improved basis for protection of human health and the environment. The T&sk Force provides an open, freely ac- cessible forum for the exchange of ideas and information, which bene- fits all of its members. The T&sk Force is mandated to report to Congress yearly on its ac- tivities. During its tenth year (1987/88), the Tbsk Force's activities were focused in the following areas: • Long-term planning • Public education and communication • Health professional education • Effects of pesticides on human health • Environmental epidemiology. These activities, described in Chapter 2, were directed by subcommit- tees of both the Task Force and scientific workshops, involving scientists from academia, research institutions, industry, and Government. The recommendations to Congress that originated from the year's Tksk Force activities are presented in Chapter 3. In 1988, the Tksk Force will contin- ue its efforts in the areas of effects of pesticides on human health, pub- lic education and communication, and health professional education; de- velop reports on these activities; and consider other subjects for future activities. 3 ------- Chapter 2 ACTIVITIES OF THE WORKING GROUP IN 1987/88 The Task Force Working Group met quarterly to exchange infor- mation, discuss environmental health issues of common interest, and initiate and direct activities of its subcommittees. The Working Group reviewed and revised its long-term plan of activities. The Project Group on Public Education and Communication held the Workshop on the Role of Government in Health Risk Communication and Public Education and, as recommended by that Workshop, became the Interagency Group on Public Education and Communication. An editorial committee pre- pared the proceedings of the workshop for publication, and the Intera- gency Group initiated planning for a workshop on evaluation of health risk communication programs. The Interagency Education Program Liai- son Group (IEPLGJ completed and published the Report of the Workshop on Community as Patient and initiated planning of additional activities to focus on the role of the health professional in environmental health issues. A planning committee began work in preparation for a major workshop on the effects of pesticides on human health. The Working Group considered the results of a feasibility study on preparing an en- vironmental epidemiology reference document. Public Education and Communication In keeping with the Task Force's emphasis on education as a means of reducing or preventing disease, the Project Group on Public Education and Communication was established to focus on communi- cating information about environmental factors and human disease to the general public. A recommendation of the Project Group's January 1987 Workshop on the Role of Government in Health Risk Communica- tion and Public Education was that the Group be renamed the Interagen- cy Group on Public Education and Communication and be expanded to include representatives of all Tksk Force Agencies. The role of the Inter- 5 ------- agency Group is to enhance the collaboration, sharing of information, and coordination of risk communication and education efforts of mem- ber Agencies and other Federal Agencies. The Interagency Group de- veloped a proposed plan of activities through 1990. Role of Government in Health Risk Communication and Public Education The Workshop on the Role of Government in Health Risk Commu- nication and Public Education was held in January 1987 to explore ex- isting Federal risk communication activities, identify gaps in research and practice that need to be addressed, and develop effective strategies for interprogram and inter-Agency cooperation in risk communication activities. The participants included Government policy makers, pro- gram administrators, risk communicators, scientists, and public health professionals from Federal, State, and local government, as well as rep- resentatives from academia, citizens' groups, the media, business, and industry. The Workshop participants agreed on the importance of risk com- munication by Government Agencies, recognizing that the goal should be to produce an informed public who are involved in decisions that af- fect their lives and their property. Risk communication programs need to include guidelines on which to base the definition of objectives and the development of standards and measures for evaluating risk commu- nication programs and performances. To address these needs, the partic- ipants discussed a broad and diverse set of risk communication princi- ples and guidelines for use by Federal Agencies. An overriding theme of discussion was that risk communication must be understood as a two- way interactive process based on mutual respect and trust. An editorial committee prepared the proceedings of the Workshop for publication (see Appendix D for availability). The proceedings include: • Overview of the principles and guidelines for improving risk communication • Perspectives on Government risk communication programs and descriptions of programs • Case studies of Government risk communication programs, including the Newark dioxin case, the BKK Corporation landfill 6 ------- case, a phosphorus release in Ohio, and notification of workers exposed to 2-naphthylamine • Descriptions of various aspects of the risk communication process. Appendixes include an inventory of Government risk communication programs and manuals on risk communication for Government commu- nicators and for plant managers. Evaluation of Health Risk Communication Programs The importance of incorporating measures of effectiveness into the planning of risk communication programs was a recurring theme of the January 1987 Workshop on the Role of Government in Health Risk Communication and Public Education. Therefore, the Interagen- cy Group on Public Education and Communication decided that a workshop on evaluation would be a useful sequel to its first risk com- munication activity. A planning committee defined the workshop ob- jective: to provide practical guidance on planning and evaluation as part of implementing environmental and health risk communication programs. In preparation for the June 1988 Workshop on Evaluation and Effective Risk Communication, papers were commissioned on evaluation methodology and research and the application of methods and theory to programs. Health Professional Education The Task Force's Interagency Education Program Liaison Group continued its efforts to increase awareness of environmental health is- sues among health professionals by utilizing multi-Agency planning and participation. The report of the 1986 Workshop on the Commu- nity as Patient was published (see Appendix D for availability). The report includes recommendations for research and education and im- plementation strategies relevant to the role of academic occupational and environmental medicine physicians in reducing risks associated with hazardous substances in the community. Case studies, describing the management of a community impact of an environmental hazard and a community educational outreach effort, are also presented. As a special aid for health professionals, the report provides two sample occupational/environmental history forms and urges their use in clin- ical practice. 7 ------- The Agency for Toxic Substances and Disease Registry was guided by the recommendations contained in the Task Force's Ninth Report in developing its newly mandated (Superfund Amendments and Re- authorization Act of 1986) Health Education Program. Specifically, ATSDR program personnel believed that an integrated network of academically based environmental and occupational medical clinics could best address the Tbsk Force's proposed recommendations. Such a network was created in 1987 by ATSDR in part to examine the long- term implications and utility of the proposed recommendations. This program outcome provides one small but vivid example of compliance with the Congressional intent by stimulating cooperation between EPA and the Public Health Service to implement comprehen- sive strategies to reduce or prevent exposure to hazardous substances that may produce environmentally related disease or illness. Environmental and Occupational Asthma In cooperation with NHLBI and NIOSH, the IEPLG established a steering committee, composed of clinicians and researchers, to de- velop a plan for a Workshop on Environmental and Occupational Asthma. The steering committee defined the following general goals for the workshop: • Define environmental and occupational asthma and identify respiratory hazards resulting from environmental as well as occupational exposures • Relate the current knowledge to needed skills and behaviors within the practice patterns of physicians, particularly primary care and other first contact providers (what do primary care physicians need to know?) • Provide mechanisms for reinforcing physicians' skills and behaviors in regard to preventing, treating, and reporting of environmental and occupational asthma • Provide surveillance mechanisms for the recognition of environmental and occupational asthma • Suggest further needs and efforts, such as clinical assessment, epidemiology, management, control, and prevention, necessary to identify and protect individuals at risk 8 ------- • Identify research gaps and recommend new research initiatives. TOXNET Information Dissemination In cooperation with ATSDR and other Federal Agencies, the IEPLG began planning an effort to disseminate information about the National Library of Medicine's Toxicology Data Network (TOXNET] to health professionals. TOXNET is a computerized on-line system of toxicologically oriented data banks operated by the National Library of Medicine. TOXNET's three data banks—the Hazardous Substances Data Bank, the Registry of Toxic Effects of Chemical Substances, and the Chemical Carcinogenesis Research Information System—permit efficient access to valuable data on potentially toxic or otherwise haz- ardous substances. With the growing awareness of toxic contamina- tion and the potential link between disease and a wide range of en- vironmental factors, the public increasingly will expect health care practitioners to diagnose and treat environmentally and occupational- ly related disease. TOXNET enables users to obtain data on known chemicals and identify unknown chemicals based upon their physical characteristics (e.g., physical form, color, odor, etc.). The target audi- ence for the information dissemination activity will be primary care practitioners of family, preventive, and internal medicine. Effects of Pesticides on Human Health In response to the concerns of several Tksk Force Agencies and to public concern about pesticides, the Working Group undertook the planning of a workshop to assess the effects of pesticides on human health. With a focus on chronic, low-level exposures to pesticides, working groups of scientists were established to address several toxi- cological endpoints; carcinogenicity, developmental toxicity, reproduc- tive toxicity, neurotoxicity, and immunotoxicity. Another working group specifically addressed exposure to pesticides through all media and the relationship of exposure to the chronic health effects. The working groups were to consider the following questions in developing their papers: • What is the potential of pesticide chemicals to cause adverse health effects? • Is there evidence that at current levels of exposure, human health is being compromised? 9 ------- • Are testing and toxicological risk assessments adequate to detect the kinds of effects that might occur? • How can the capability to monitor for potential adverse effects of pesticides be improved? • What are the major gaps in our current understanding of the science and what are the needs for future research? The working groups papers will form the basis for discussions at the workshop, scheduled for May 1988. Environmental Epidemiology The Working Group conducted a feasibility study to determine the need for an environmental epidemiology reference document for phy- sicians. Three options were considered: (1) definitions of epidemio- logic terms relevant to environmental study; (2) practical guidelines for clinicians on how to do office-based epidemiology; and (3) a desk reference for physicians with information on the most important expo- sures and referrals. The feasibility study included the identification of existing, publicly available, computerized data bases on environmental health and risk assessment. Approximately 70 relevant data bases were identified, as well as several related generic data bases. In ad- dition, literature searches were conducted to identify epidemiologic and environmental glossaries and relevant publications. It was noted that the International Programme on Chemical Safety is in the pro- cess of compiling internationally agreed on definitions for the terms most frequently used in toxicological and epidemiological studies. In view of existing and planned information resources, the Working Group decided not to proceed with this activity. 10 ------- Chapter 3 RECOMMENDATIONS The Task Force on Environmental Cancer and Heart and Lung Disease recommends strategies and other measures that might help in the determination and quantification of relationships between environ- mental pollution and human disease and in preventing or reducing the incidence of environmentally related disease. The findings and conclu- sions developed by participants in scientific meetings sponsored by the T&sk Force are considered in the formulation of recommendations. Ac- cordingly, the recommendations stated in this report are a summary of the conclusions developed by participants in those meetings. These recommendations do not necessarily reflect the unanimity of views of the Tksk Force member Agencies. Risk Communication and Public Education At the Workshop on the Role of Government in Health Risk Com- munication and Public Education, educators, communications practi- tioners, representatives of Federal, State, and local government, the media, industry, academia, and private interest groups developed rec- ommendations, guidelines, and strategies for improving the communi- cation of risk information to the public. The goal of risk communica- tion should be to assure that the public is informed and involved in the decision-making process in a thoughtful, solution-oriented manner. Workshop participants emphasized that risk communication must be understood as a two-way interactive process based on mutual respect and trust. The Workshop participants also urged that risk communication be recognized as an essential component of the risk management process. The satisfactory resolution of risk situations requires a credible risk as- sessment, well documented and fairly executed risk management that 11 ------- addresses the issues that concern the affected population, and an open, interactive way to communicate with the affected population. Risk as- sessors and risk managers need to be aware of the intricacies of risk communication, and the entire risk management process must take into account the need for communicating with the public, decision- makers, and all interested parties. Recommendation h Coordination and Collaboration, Ongoing mechanisms and networks are needed for sharing information among Agencies about risks, risk assessment, risk management, and risk communication. Government Agencies are major sources of information on risks, and it is important to sustain trust in their credibility as sources of in- formation. Government Agencies have different mandates, which ne- cessitates cooperation in risk assessment and risk communication. En- hancing coordination and collaboration among Agencies can reduce the possibility of confusion. Coordination within and between Agencies, including Agencies at the Federal, State, and local level, is critical to effective efforts at risk communication. Efforts should be devoted to building stronger bridges among agencies and organizations. Interagency and intra-agency com- munications should be more coordinated as a matter of routine. Recommendation 2: Research Agenda. A national agenda should be established for research on risk communication that identifies gaps and sets priorities. Many of the current principles and guidelines for risk communi- cation are based on experience and observation, not on systematic re- search. Although some related research has been conducted, the num- ber of studies that focus specifically on risk communication is small. There have been only limited efforts to develop or exploit contribu- tions from the relevant social science disciplines and evaluate existing risk communication programs. Research is needed on factors that enhance or diminish the effec- tiveness of risk communication, including basic and applied research on psychological, sociological/political, anthropological, and economic processes, risk comparisons, legal and ethical issues, and processes of mediation, negotiation, and public involvement. 12 ------- Recommendation 3: Targeting and Transmitting Risk Information. Risk information should be specifically tailored in both content and form to the needs of the target public groups in particular communities. An important area of research relevant to risk communication is how to tailor messages to the specific community. The public is not a single monolithic entity, and no single risk message is appropriate for all audiences. The most effective information is designed for specific audiences and takes into account the characteristics of the community. The risk communicator should study the history and dynamics of the community and develop a profile that identifies how that community has traditionally solved problems. The news media play an important role in transmitting risk infor- mation to the public, and the risk communicator should consider the media and other channels of communication in developing the commu- nity profile. These other channels include direct advertising, public meetings, one-on-one contacts or counseling, health professionals, and community networks. The selection of the most effective channel or combination of channels should be based primarily on the community characteristics and content of the information. 13 ------- Appendix A SECTION 402 OF PUBLIC LAW 95-95 ------- Appendix A SECTION 402 OF PUBLIC LAW 95-95 Clean Air Act Amendments of 1977 "INTERAGENCY COOPERATION ON PREVENTION OF ENVIRONMENTAL CANCER AND HEART AND LUNG DISEASE Sec. 402(a) Not later than three months after the date of enactment of this section, there shall be established a Task Force on Environmental Cancer and Heart and Lung Disease (hereinafter referred to as the Task Force'), The Task Force shall include representatives of the Environmental Protection Agency, the National Cancer Institute, the National Heart, Lung, and Blood Institute, the National Institute (for) Occupational Safety and Health, and the National Institute (of) Environmental Health Sciences, and shall be chaired by the Adminis- trator (or his delegate). (b) The Task Force shall— (1) recommend a comprehensive research program to deter- mine and quantify the relationship between environmental pollution and human cancer and heart and lung disease; (2) recommend comprehensive strategies to reduce or eliminate the risks of cancer or such other diseases associated with environmental pollution; (3) recommend research and such other measures as may be appropriate to prevent or reduce the incidence of environmentally related cancer and heart and lung dis- eases; 17 ------- (4) coordinate research by, and stimulate cooperation between, the Environmental Protection Agency, the Department of Health, Education, and Welfare, and such other Agencies as may be appropriate to prevent environmentally related cancer and heart and lung diseases; and (5) report to Congress, not later than one year after the date of enactment of this section and annually thereafter, on the problems and progress in carrying out this section." 18 ------- Appendix B TASK FORCE ON ENVIRONMENTAL CANCER AND HEART AND LUNG DISEASE ------- Appendix B TASK FORGE ON ENVIRONMENTAL CANCER AND HEART AND LUNG DISEASE PLENARY AND ALTERNATES 1987/88 Lee M. Thomas, Administrator, U.S. Environmental Protection Agency Chairperson Richard H, Adamson, Director, Division of Cancer Etiology, NCI Scott R. Baker, Special Assistant to the Assistant Administrator, Office of Research and Development, EPA, Working Group Chairperson Vincent T. DeVita, Director, NCI Manning Feinleib, Director, NCHS Jean French, Science Advisor, Office of the Director, CDC/NIOSH John A. Gr on vail, Chief Medical Director, VA Suzanne S. Hurd, Director, Division of Lung Diseases, NHLBI Claude Lenfant, Director, NHLBI James O. Mason, Director, CDC, and Administrator, ATSDR 21 ------- J. Donald Millar, Director, CDC/NIOSH David P. Rail, Director, NIEHS Ken Sexton, Director, Office of Health Research, Office of Research and Development, EPA, Working Group Chairperson William Tallent, Assistant Administrator, Agriculture Research Service, USDA J.W. Thiessen, Deputy Associate Director Office of Energy Research, DOE Andrew Ulsamer, Acting Associate Executive Director for Health Sciences, CPSC Ralph Yodaiken, Director, Office of Occupational Medicine, OSHA Frank E. Young, Commissioner, FDA 22 ------- WORKING GROUP MEMBERS 1987/88 Scott R. Baker, Special Assistant to the Assistant Administrator, Office of Research and Development, EPA Chairperson and Ken Sexton, Director, Office of Health Research, Office of Research and Development, EPA Chairperson Richard H. Adamson, Director, Division of Cancer Etiology, NCI Max Lum, Medical Education Specialist, ATSDR Nathaniel Barr, Office of Health and Environmental Research Office of Energy Research, DOE Zakir H. Bengali, Division of Lung Diseases, NHLBI James R. Fouts, Senior Scientific Advisor to the Director, NIEHS Jean French, Office of the Director, Science Advisor, CDC/NIOSH Kailash C. Gupta, Director, HSHL, CPSC Jeffrey A. Lybarger, Chief, Epidemiology and Medicine Branch, ATSDR Richard M. Parry, Jr., Assistant to the Administrator, Agriculture Research Service, USDA Maria Pavlova, National Expert on Toxicology, EPA - Region II Michael Peterson, Senior Policy Analyst, Office of the Assistant Secretary of Defense (Health Affairs), DoD 23 ------- A. Richey Sharrett, Chief, Social and Environmental Epidemiology Branch, Division of Epidemiology and Clinical Applications, NHLBI Barclay M. Shepard, Director, Agent Orange Project Officer Karen Skinner, Special Assistant to the Commissioner, FDA Diane Wagener, Division of Epidemiology and Health Promotion, NCHS Ralph Yodaiken Director, Office of Occupational Medicine, OSHA 24 ------- INTERAGENCY EDUCATION PROGRAM LIAISON GROUP 1987/88 Max Lum, Medical Education Specialist, ATSDR Chairperson E. Joseph Bangiolo, Office of Cancer Communications, NCI Paul W. Bergman, Pesticide Use and Impact Assessment Extension Service, LJSDA Lee Gigliotti, Acting Chief, Health Promotion Sciences Branch, Division of Cancer Prevention and Control, NCI Sydney Parker, Chief, Prevention, Education, and Manpower Branch, Division of Lung Diseases, NHLBI fames R. Secrest, Chief, Multidisciplinary Resource Development Branch, Division of Medicine, HRSA Ralph Yodaiken, Director, Office of Occupational Medicine, OSHA 25 ------- INTERAGENCY GROUP ON PUBLIC EDUCATION AND COMMUNICATION* 1987/88 Maria Pavlova, National Expert on Toxicology, EPA - Region II Chairperson Frederick Allen, Associate Director Office of Policy Analysis, EPA Donald Barnes, Science Advisor, Office of Pesticides and Toxic Substances, EPA Alexander Cohen, Deputy Director, Division of Biomedical and Behavioral Science, CDC/NIOSH Ann Fisher, Senior Economist, Office of Policy Analysis, EPA Jean French, Science Advisor, Office of the Director, CDC/NIOSH Michael D. Hogan, Special Assistant for Risk Assessment, Biometry and Risk Assessment Program, NIEHS Vincent Covello, Director for Risk Assessment and Risk Management Research, National Science Foundation Thomas W. Devine, Director, Office of Policy, Budget, and Program Management, EPA Susan Diehl, Risk Assessment Coordinator Office of the Regional Administrator, EPA — Region IV Edward A. Klein, Director, TSCA Assistance Office, Office of Toxic Substances, EPA Christine Krutszch, Public Affairs Specialist, Office of Prevention, Education, and Control, NHLBI Stanley L. Laskowski, Deputy Regional Administrator, EPA — Region IV Max Lum, Medical Education Specialist, ATSDR 'Became the Interagency Group on Public Education and Communication in January 1967, 26 ------- James Marshall, Director, Office of Internal Affairs, EPA — Region II David McCallum, Senior Fellow, Institute for Health Policy Analysis, Georgetown University School of Medicine Richard M. Parry, Jr., Assistant to the Administrator, Agricultural Research Service, USDA Peter Preuss, Director, Office of Health and Environmental Assessment, Office of Research and Development, EPA Rose Mary Romano, Chief, Information Projects Branch, Office of Cancer Communications, NCI Robert j. Scheuplein, Deputy Director, Office of the Director, Toxicological Services, FDA Karen Skinner, Special Assistant to the Commissioner, FDA Frank Tooper, Assistant to the Assistant Secretary for Nuclear Energy, Office of Nuclear Energy, DOE Andrew Ulsamer, Director, Health Services, CPSC Michael White, Associate Director, NHLBI Jeannette Wiltse, Air Toxics Coordinator, Office of Air and Radiation, Office of Research and Development, EPA 27 ------- Appendix C MISSION STATEMENT OF THE NEW TASK FORCE MEMBER AGENCY: AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY ------- Appendix C AGENCY FOR TOXIC SUBSTANCES AND DISEASE REGISTRY MISSION The mission of ATSDR is to prevent or mitigate adverse human health effects and diminished quality of life resulting from expo- sure to hazardous substances in the environment. LEGISLATIVE AUTHORITY The Agency for Toxic Substances and Disease Registry (ATSDR) is part of the Public Health Service (PHS) and is based in Atlanta, Georgia. It was created by Congress to implement the health-related sections of laws that protect the public from hazardous wastes and environmental spills of hazardous substances. ATSDR derives its authority from three separate acts of Congress. 1. The Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA), commonly known as the "Super- fund" Act, provided Congressional mandate to remove or clean up abandoned and inactive hazardous waste sites and to provide Feder- al assistance in toxic emergencies. Congress made the Environmen- tal Protection Agency (EPA) the lead agency in implementing CERCLA and created ATSDR to implement the health-related sec- tions of the Act. 31 ------- 2. In 1984, amendments to the Resource Conservation and Recovery Act of 1976 (RCRAJ, which provides for the management of legit- imate hazardous waste storage or destruction facilities, charged the ATSDR to conduct health assessments at these sites, when re- quested by EPA, States, or individuals, and to assist EPA in deter- mining which substances should be regulated and the levels at which they may pose a threat to human health. 3. In 1986, amendments to CERCLA, known as the Superfund Amend- ments and Reauthorization Act of 1986 (SARA], broadened ATSDR's responsibilities in the areas of health assessments, toxicological data bases, information dissemination, and medical education. ORGANIZATION ATSDR's three Offices are the Office of the Associate Administrator (OAA), the Office of External Affairs (OEA), and the Office of Health As- sessment (OHAJ. The OAA is responsible for the Agency's planning and budget and develops overall policy. OEA is responsible for developing ex- posure and disease registries, planning and conducting research, producing toxicological profiles, responding to legislation, developing agreements and contracts, providing liaison with EPA and technical assistance to State and local agencies, maintaining the list of areas closed or restricted be- cause of contamination, and coordinating the activities of ATSDR's region- al staff—those persons responsible for coordinating ATSDR programs within 10 regions across the United States. OHA provides emergency re- sponse to toxic and environmental disasters, gives health consultations in public health emergencies, makes health assessments of hazardous waste sites, provides technical assistance to agencies and organizations, and es- timates health risks to humans from exposure to hazardous substances. The program areas in which ATSDR operates are as follows: • Health Assessments—to evaluate data and information on the re- lease of hazardous substances into the environment in order to: as- sess any current or future impact on public health, develop health advisories or other health recommendations, and identify studies or actions needed to evaluate and mitigate or prevent human health effects. 32 ------- Toxicological Profiles—to summarize and interpret available data on the health effects of hazardous substances and to initiate toxico- logical and health effects research, where needed. Emergency Response—to provide health-related support in public health emergencies, including public health advisories, involving ex- posure to hazardous substances. Exposure and Disease Registries—to establish and maintain a reg- istry of serious diseases and illnesses in persons exposed to toxic substances as a result of environmental exposure and a registry of persons exposed to hazardous substances. Health Effects Research—to expand knowledge of the relationship between exposure to hazardous substances and adverse human health effects through epidemiological, toxicological, laboratory, and other studies on hazardous substances. Health Education—to develop and disseminate, to physicians and other health care providers, materials on the health effects of toxic substances. Literature Inventory/Dissemination—to establish and maintain, through the National Library of Medicine (NLM), a publicly acces- sible inventory on hazardous substances. Worker Health and Safety—to assist in occupational safety and health service and research programs for protecting workers at Su- perfund sites and workers who respond to emergency releases of hazardous substances. List of Areas Closed to the Public—to maintain a nationwide list of sites closed or restricted to the public because of contamination by hazardous substances. 33 ------- Appendix D SELECTED PUBLICATIONS FROM THE TASK FORCE ON ENVIRONMENTAL CANCER AND HEART AND LUNG DISEASE ------- Appendix D SELECTED PUBLICATIONS FROM THE TASK FORCE ON ENVIRONMENTAL CANCER AND HEART AND LUNG DISEASE The following publications represent some of the contributions to the study of environmental disease, its causes, treatment, and prevention, made by Task Force-sponsored workshops, symposia, conferences, and research reports. 1. Environmental Cancer and Heart and Lung Disease, Annual Reports to Congress, 1978-1986, (Available from EPA Office of Health Re- Rearch and NTIS.) Ninth Annual Report. 1986. Eighth Annual Report. 1985. NTIS Accession No. PB87 184412; paper copy $13.95; microfiche $6.50. Seventh Annual Report. 1984. NTIS Accession No. PB85 236842; paper copy $10.00; microfiche $4.50. Sixth Annual Report. 1983. NTIS Accession No. PB84 219187; paper copy $11.50; microfiche $4.50. Fifth Annual Report. 1982. NTIS Accession No. PB83 155762; paper copy $16.00; microfiche $4.50. Fourth Annual Report. 1981. NTIS Accession No. PB82 200429; paper copy $12.00; microfiche $4.00. Third Annual Report. 1980. NTIS Accession No. PB81 174716; paper copy $11.00; microfiche $3.50. Second Annual Report. 1979. Available from EPA Office of Health Research. 37 ------- First Annual Report, 1978. Available from EPA Office of Health Research. These annual reports describe the activities and accomplishments of the Task Force for the preceding year. Summaries of the various Task Force Project Group activities are also given, with emphasis on major workshops and reports undertaken during the year. Recommendations for research needed to elucidate environment-disease relationships are presented. 2. Environmental Health-Related Information, A Bibliographic Guide to Federal Sources for the Health Professional. 1984. (Available only from NTIS; NTIS Accession No. PB84 22981; paper $25.00; microfiche $4.50.) This annotated bibliography contains selected materials on occupational and environmental health available from Federal organizations. It in- cludes audiovisual presentations as well as publications related to the diagnosis, treatment, prevention, and limitation of environmentally re- lated disease. The bobk is organized by categories chosen to guide the user to the desired materials as efficiently as possible. Appendixes pro- vide information on NCI Cancer Centers, Educational Resource Cen- ters supported by NIOSH, Federally funded clearinghouses for environ- mental and occupational health issues, and accredited residencies in preventive and occupational medicine. 3 Exposure Assessment: Problems and Prospects, Journal of Tbxicology— Clinical Toxicology, Vol. 21, Nos. 1 and 2,1983-84. Special Symposium Issue. Experts from government, academia, and clinical research institutions presented papers describing various models and approaches currently used to assess human exposure to toxic substances. These papers cover the various settings and purposes for which exposure determinations are undertaken. Each paper is followed by references and the discussion that took place at the symposium. 38 ------- 4. Summary of the Workshop on Exposure to Environmental Agents, Their Metabolism, and Mechanisms of Toxicity; Research Needs. August 1981. (NTIS Accession No. PB82 212895; paper $13.50; microfiche $4.00.) This summary presents the full text and rationale of 72 research recom- mendations developed through a consensus of scientific experts. The document is a compilation of research needs for environmental cancer and heart and lung disease in areas such as epidemiology, exposure quantification and monitoring, metabolism, and disease processes. Both short- and long-term needs are identified in a balanced focus on basic and applied environmental disease research. 5 Position Papers from the Workshop on Exposure to Environmental Agents, Their Metabolism, and Mechanisms of Toxicity. Published as a Special Issue of the Journal of Environmental Science and Health, Vol. 17A, No. 4, July 1982. A wide range of topics was covered in this publication, including: initi- ation/promotion concepts of carcinogenesis, toxicologic interactions and pathogenesis of lung and heart disease, and total exposure models in animals and humans. 6 Legal and Administrative Impediments to the Conduct of Epidemiologic Research. 1984. This study was conducted to determine whether significant modifications or relaxation in impediments to data access and record linkage have oc- curred since the Task Force recommendation on this issue in its Fourth Annual Report to Congress. Recent literature was reviewed, and Federal epidemiologists involved with these issues were interviewed. 7 Quarterly Calendar. To facilitate information dissemination within a 3-month time frame, the Tksk Force Calendar announces meetings, conferences, symposia, 39 ------- courses, public hearings, and workshops that pertain to environmental pollution and disease. 8 Workshop on Environmental Education Needs of Health Professionals. 1979. The summary report of this workshop identifies the needs of health pro- fessionals in environmental education and develops action plans to en- hance their capability to prevent environment-related disease. 9 Recommendations on Environmental and Occupational Education of Health Professionals. 1980. These recommendations outline a strategy through which health pro- fessionals can more effectively prevent environment-related disease. Included in the strategy are the establishment of an Interagency Edu- cation Program Liaison Group and specific recommendations address- ing curricula, faculty, students, continuing education, and research components. 1 0 Report of the Workshop on Environmentally Related Nononcogenic Lung Disease, Environmental Research, Vol. 38, No. 2, 1985. This report is intended to reflect the current state of knowledge on en- vironmentally related nononcogenic lung disease. It contains 45 re- search recommendations and supporting rationales that resulted from a week-long workshop. Sessions were held on epidemiology, statistics, and risk assessment; clinical research; and basic and animal research. There is an extensive list of references at the end of the report. 1 1 Report of the Seminar on Laboratory Quality Assurance, A Management Approach. 1984. This report summarizes the presentations given at a 2-day seminar sponsored by the Task Force Project Group on Quality Assurance in 40 ------- Analytical Methodology. Scientists and laboratory managers discussed the difficulties involved in producing reliable and compatible labora- tory data. A problem-solving technique was used to elicit possible so- lutions to the successful application of quality assurance at the mana- gerial level. 1 2 Strategies for Determining the Mechanisms of Toxicity. Prepared by the Subcommittee on Metabolism of the Project Group on Exposure and Metabolic Mechanisms. Journal of Toxicology—Clinical Toxicology, Vol. 23, No. 1,1985. The report poses a series of questions for developing strategies for the use of mechanistic approaches to studying the toxicity of chemicals. The questions are discussed for toxicities relevant to environmental cancer and heart and lung disease. The report is intended to provide guiding principles on how pharmacokinetic and metabolism studies should be used in toxicity experiments. 1 3 Report of the Workshop on the Contribution of Airborne Pollutants to Respiratory Cancer. Environmental Health Perspectives, Vol. 70, 1986. The report includes an overview and papers describing the contribution of radon, environmental fibers, formaldehyde, organic particles, pas- sive smoking, and metals to the incidence of respiratory cancer. Each of these airborne pollutants is discussed in the context of its inter- action with cigarette smoke and the risk of exposure to human popu- lations. Data gaps and uncertainties are identified, and recommenda- tions are suggested for research to reduce these uncertainties. 14. Report of the Workshop on Environmental Toxicity and the Aging Process. 1987. New York: Alan R. Liss, Inc. As an effort to provide impetus to a multidisciplinary approach to the study of interactions between factors in the environment and human aging processes, two commissioned papers were prepared. One paper addresses the issues from the gerontological perspective and the other 41 ------- from the toxicological perspective. The report will also include recom- mendations for future research. 15 Report of the Special Grand Rounds: Women at Work. 1986. (NTIS Ac- cession No. PB87 184263; paper copy $13.95; microfiche $6.50.) The report is a compilation of presentations on women's occupational health issues. These include an overview discussion of possible health effects associated with exposure to video display terminals and toxic substances in the workplace, and an annotated listing of educational resources. 16 _ Report of the Workshop on the Community as Patient. 1987. The report includes two case studies illustrating various roles of health professionals in responding to environmental health concerns of the community. The highlights of the workshop discussions and recom- mendations for research and education are also presented. 17. Effective Risk Communication: The Role and Responsibility of Govern- ment and Non-Government Organizations. In press. New York: Plenum Press. The report includes an overview of the principles and guidelines for improving risk communication, descriptions of Government risk com- munication programs and case studies, and manuals on risk commu- nication for Government communicators and plant managers. Future directions for research in risk communication are highlighted. 42 ~u. S. GOVERNMENT PRINTING OFFICE: 1989/648-163/87099 ------- To obtain ordering information on any of the selected publications, please complete the card below and return to Office of Health Research (RD-683) U.S. Environmental Protection Agency 401 M Street, SW Washington, DC 20460 (202) 382-5895 A limited number of free copies of these publications is available. Name Title Affiliation Street City State Zip Please circle the item number of the publication(s) you wish to receive. 1 Years: 2345 6789 10 11 12 13 14 15 16 17 43 ------- v»m' y ; ' . • „ .. U.tS. Environmental Protection Agency Public Health Service National Institutes of Health National Cancer Institute National Heart, Lung, and Blood Institute National Institute of Environmental Health Sciences Centers for Disease Control National Institute for Occupational Safety and Health National Center for Health Statistics Food and Drug Administration Agency for Toxic Substances and Disease Registry Department of Energy Consumer Product Safety Commission Occupational Safety and Health Administration Department of Agriculture c Department of Defense Veterans Administration CERI-89-104 i * ------- |