TSCA
Chemicals-in-Progress
Bulletin
Office of Pesticides & Toxic Substances
(OPTS)
Vol. 4, No. 1	January 1983
This news bulletin is intended to inform all persons concerned with the Toxic Substances Control Act (TSCA) about recent
developments and near-term plans. For further information or to request copies of documents mentioned, write the Industry
Assistance Office (IAO), (TS-799) EPA, Washington, D C. 20460, or call toll-free 800-424-9065 or, in Washington, D.C., or from
outside the continental USA, (202) 554-1404.
REGULATORY & REQUIRED ACTIONS
TESTING OF CHEMICAL SUBSTANCES
AND MIXTURES...SECTION 4
Section 4 of TSCA gives EPA authority to require manu-
facturers or processors of existing chemicals—those
already in commerce and subject to TSCA—to test the
toxic effects of a designated substance. To require test-
ing EPA must find that the chemical may present an
unreasonable risk; that there are insufficient data avail-
able with which to perform a reasoned risk assessment;
and that testing is necessary to generate such data. A
test rule may also be based on an EPA finding of sub-
stantial production and exposure to humans or the
environment, in addition to findings of insufficient data
and need for testing.
Under section 4(e) an Interagency Testing Committee
(ITC) was established to recommend chemicals to EPA
for priority consideration. The ITC cannot recommend
more than 50 chemicals or categories of chemicals for
testing and EPA must respond within one year to each
recommendation by starting rulemaking under section 4
or giving reasons for not doing so.
CA Environmental Effects Testing Not Needed
Section 4 testing of chlorendic acid (CA) is not war-
ranted at this time because environmental release of the
substance and its manufacturing precursor, chlorendic
anhydride (CAN), is extremely limited, according to
recent Federal Register notice. The EPA notice also said
available data indicate that such releases are unlikely to
present an unreasonable risk.
In the October 1 2, 1982 notice (47 FR 44878) EPA was
responding to an ITC recommendation included in its
October 30, 1981, ninth report to the Agency. In that
report the ITC recommended to EPA that CA be consid-
ered for environmental effects testing, including chemi-
cal fate, acute and chronic toxicity to fish and aquatic
invertebrates, and toxicity to aquatic microphytes and
algae.
The notice said there are only two manufacturers of
CA/CAN in the United States. CA is also imported by
one of the two manufacturers and releases of CA/CAN
by these two firms are low, localized and within applica-
ble permit limits, according to the notice. Based on
information available to EPA, including confidential
business information from the two firms, the notice said
that EPA has no basis for finding CA/CAN might present
an unreasonable risk to the environment at this time.
Limited TCEP Exposure, No Rulemaking
Available data on tris(2-chloroethyl)phosphite (TCEP)
indicate that production and use of the chemical results
in limited exposure risk, according to a recent Federal
Register notice. Because of the finding, EPA is not initiat-
ing rulemaking to require testing of TCEP, the notice said.
The data show that production and use produce only
slight occupational exposure and no consumer exposure
and there is no known release to the environment, a
November 1, 1 982 (47 FR 49466) notice said.
The ITC had designated health and environmental
effects testing of TCEP in its ninth report to the Agency.
It asked that TCEP be tested for the following health and
environmental effects: pharmacokinetics and metabo-
lism, subchronic and reproductive effects, chemical
fate, and acute toxicity to fish, aquatic invertebrates and
algae.
The Federal Register notice said that TCEP is manufac-
turered by three companies in the United States and no
one has imported it since at least 1977. The decision not
to test in part was based on confidential business infor-
mation. The notice also said TCEP production is a closed
1

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system and site limited. The compound is made in
batches and the production complies with OSHA regula-
tions controlling workplace releases of ethylene oxide
and other organics used in the production of TCEP. En-
gineering controls being used by the three manufactur-
ers are designed to help eliminate the release of volatile
chemicals exhibiting significant toxicity, such as ethyl-
ene oxide, according to the notice.
EPA Negotiates Testing for 4-CBTF
EPA will not initiate rulemaking to require testing for
4-chlorobenzotrifluoride (4-CBTF) at this time because
the sole domestic manufacturer of the substance pre-
sented a testing plan that was tentatively acceptable to
the Agency. The substance had been placed on the ITC
priority testing list on October 30, 1981 (47 FR 5456).
The ITC designated 4-CBTF for testing for chronic
effects, chemical fate and bioconcentration.
A November 8,1982 notice (47 FR 50555) said Occiden-
tal Chemical Corp., the sole U.S. producer of the chemi-
cal, presented acceptable health and environmental
effects testing plans for 4-CBTF after the ITC designa-
tion. The Occidental proposal consists of tiered systems
for testing both health and environmental effects, with
lower tier tests acting as triggers to additional testing if
needed, or as stop points following review by EPA. The
Occidental plan divides health effects testing into acute
toxicity screening (which already has been completed),
base set of tests, conditional tests and additional mam-
malian testing. The environmental effects testing will be
divided into screening, base set of tests and conditional
tests.
ITC Adds Chemicals to List
In its eleventh report (November 3, 1982) the ITC added
11 chemicals to its list for priority consideration and
response by EPA wit hin 12 months. The ITC also recom-
mended one group of chemicals, carbofuran interme-
diates, for priority consideration, but did not specify that
EPA had to respond about the group within 12 months.
The designated chemicals in the eleventh report are:
bis(2-ethylhexyl) terephthalate, dibutyltin bis(isooctyl
maleate), dibutyltin bis(isooctyl mercaptoacetate), dibu-
tyltin bisflauryl mercaptide), dibutyltin dilaurate, di-
methyltin bisfisooctyl mercaptoacetate), monobutyltin
tris(isooctyl mercaptoacetate), monomethyltin tris(iso-
octyl mercaptoacetate), 1,3 dioxolane, 4-( 1,1,3,3-tetra-
methylbutyl) phenol, tris(2-ethylhexyl) trimellitate.
Elsewhere in this issue of the Bulletin are reports of EPA
actions on chlorendic acid, tris(2-chloroethyl) phosphite
and 4-chlorobenzotrifluoride. In its November 3, 1982
letter to the EPA Administrator the ITC issued a revised
designation concerning alkyltin compounds, a category
included in the ITC seventh report for priority considera-
tion. The ITC said it reexamined the 33 alkyltin com-
pounds identified in the seventh report plus additional
alkyltins in commerce that were later identified by EPA
and industry. Based on a review of available information
it now has on alkyltins compounds, particularly the level
of production and type of use, the ITC has decided to
designate seven alkyltin compounds for priority consid-
eration and defer the remainder. These seven are
included in the 11 designated chemicals mentioned
above.
Eleventh ITC Report
Chemical/Group
Recommended Studies
Designated for response within 12 months
Monomethyltin tris(iso-
octyl mercaptoacetate)
Dimethyltin bis(isooctyl
mercaptoacetate)
Monobutyltin tris(iso-
octyl mercaptoacetate)
Dibutyltin bisfisooctyl
mercaptoacetate)
Dibutyltin bis(lauryl
mercaptide)
Dibutyltin dilaurate
Dibutyltin bis(isooctyl
maleate)
Bis(2-ethylhexyl
terephthalate
1,3-Dioxolane
4-1,1,3,3-Tetramethyl-
butyl phenol
Chemical Fate: Mobility of the com-
pounds from manufacturing and
disposal sites; hydrolysis and bio-
degradation; identification of
persistent degradation products.
Environmental Effects: Acute and
chronic toxicity to fish and aquatic
invertebrates; toxicity to aquatic
plants; bioconcentration.
Health Effects: Mutagenicity;
chemical disposition and metabo-
lism; subchronic effects.
Environmental Effects and Chemi-
cal Fate; Acute and chronic toxicity
to fish and aquatic invertebrates;
toxicity to plants; bioconcentration;
chemical fate.
Health Effects: Mutagenicity; chem-
ical disposition and metabolism;
90-day inhalation toxicity.
Health Effects: Short-term tests
including mutagenicity.
Environmental Effects and Chemi-
cal Fate: Acute and chronic toxicity;
to fish and aquatic invertebrates;
toxicity to plants; bioconcentration;
chemical fate.
Health Effects: Chemical disposi-
tion and metabolism.
Environmental Effects and Chemi-
cal Fate: Acute and chronic toxicity
to fish and aquatic invertebrates;
toxicity to plants; bioconcentration;
chemical fate.
Recommended, but not designated for response
within 12 months
Carbofuran	Environmental Effects and Chemi-
intermediates	cal Fate: Acute toxicity to fish and
aquatic invertebrates; chemical fate
with particular emphasis on moni-
toring studies.
The TSCA Section 4(e) Priority List
October 1982
Chemicals and Groups Designated for Response
Within 12 Months
Entry			Date of Designation
Acetonitrile**		April 1979
Acrylamide (environmental effects)**		April 1978
Alkyl epoxides 	 October 1979
Aniline and bromo-, chloro-, and/or
nitroanilines		April 1978
Antimony (metal)**		April 1979
Antimony (sulfide)**		April 1979
Antimony trioxide** 		April 1979
Tris(2-ethylhexyl)
trimellitate
1.
2.
3.
4.
5.
6.
7.
2

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Entry	Date of Designation
8.	Aryl phosphates 	 April 1978
9.	Biphenyl 	 April 1982
10.	Bis(2-ethylhexyl) terephthalate 	 October 1982
11.	Chlorinated benzenes, mono- and, di-
(environmental effects) 	 October 1977
12.	Chlorinated benzenes, tri-, tetra-, and
penta-(environmental effects) 	 October 1978
13.	Cresols 	 October 1977
14.	Cyclohexanone 	 April 1979
15.	Dibutyltin bis(isooctyl maleate)	 October 1982
16.	Dibutyltin bis(isooctyl
mercaptoacetate) 		October 1982
17.	Dibutyltin bis(lauryl mercaptide) 		October 1982
18.	Dibutyltin dilaurate		October 1979
19.	1,2-Dichloropropane 		October 1978
20.	Dimethyltin bis(isooctyl
mercaptoacetate) 	 October 1982
21.	1,3-Dioxolane 	 October 1982
22.	Ethyltoluene	 April 1982
23.	Formamide 	 April 1982
24.	Glycidol and its derivatives 	 October 1978
25.	Halogenated alkyl epoxides	 April 1978
26.	Hexachloro-1,3-butadiene**	 October 1977
27.	Hexachlorocyclopentadiene** 	 April 1979
28.	Hydroquinone 	 November 1979
29.	Isophorone** 	 April 1979
30.	Mesityl oxide 	 April 1979
31.	4,4'-Methylenedianiline 	 April 1979
32.	Methyl ethyl ketone** 	 April 1979
33.	Methyl isobutyl ketone**	 April 1979
34.	Monobutyltin tris(isooctyl
mercaptoacetate) 	 October 1982
35.	Monomethyltin tris(isooctyl
mercaptoacetate) 	 October 1982
36.	Pyridine** 	 	 April 1978
37.	Quinone 	 November 1979
38.	4-(1,1,3,3,-Tetramethylbutyl)phenol ... October 1982
39.	Toluene** 	 	 October 1977
40.	1,2,4-Trimethylbenzene	 April 1982
41.	Tris(2-ethylhexyl) trimellitate 	 October 1982
42.	Xylenes** 	 October 1977
Other Recommended Chemicals and Groups
Entry	Date of Recommendation
1.	Carbofuran intermediates 	 October 1982
2.	Trimethylbenzenes* (except 1,2,4-Trimethyl-
benzene; see 40 in list above)	 April 1982
• see May 25, 1 982 (47 FR 22594(G))
*• In compliance with the EPA affidavit to a Federal Court, a Federal Register
disposition notice is expected to be signed by the EPA Administrator on or before
December 31, 1982.
EPA Disposition of ITC Recommendations
(Cumulative Removals from the TSCA Section 4(e) Priority List)
December 1982

Chemical/Category
Federal Register Notice
1.
Acrylamide



(health effects)
45 FR 48510
7/18/80
2.
Alkyl phthalates
47 FR 335
1/5/82
3.
Alkyltin compounds



(withdrawn)
47 FR 5456
2/5/82
4.
Benzidine-based dyes
46 FR 55005
11/5/81
5.
Benzyl butyl phthalate
47 FR 335
1/5/82
6.
Butyl glycolyl butyl



phthalate
46 FR 54487
11/2/81
7.
Chlorendic acid
47 FR 44878
10/12/82
8.
Chlorinated benzenes



(health effects)
45 FR 48524
7/18/80
9.
Chlorinated naphthalenes
46 FR 54491
11/2/81
10.
Chlorinated paraffins
47 FR 1017
1/8/82
11.
4-Chlorobenzotrifluoride
47 FR 50555
11/8/82
12.
Chloromethane
45 FR 48524
7/18/80
13.
2-Chlorotoluene
47 FR 18172
4/28/82
14.
o-Dianisidine-based dyes
46 FR 55005
11/5/81
15.
Dichloromethane
46 FR 30300
6/5/81
16.
Diethylenetriamine
47 FR 18386
4/29/82
17.
Fluoroalkenes
46 FR 53704
10/30/81
18.
Hexachloroethane
47 FR 18175
4/28/82
19.
Nitrobenzene
46 FR 30300
6/5/81
20.
Phenylenediamines
47 FR 973
1/8/82
21.
Polychlorinated terphenyls
46 FR 54482
11/2/81
22.
o-Tolidine-based dyes
46 FR 55005
11/5/81
23.
1,1,1 -Trichloroetha ne
46 FR 30300
6/5/81
24.
Tris(2-chloroethyl)



phosphite
47 FR 49466
11/1/82
COMMENCEMENT OF MANUFACTURE NOTICES:
SECTION 5
Under section 5(a){1) a person who intends to introduce
into commerce a chemical substance not on the TSCA
Inventory must notify EPA at least 90 days before begin-
ning manufacture or import. On May 15, 1979 (44 FR
28564) EPA published a statement of interim policy
concerning section 5, premanufacturing notification
(PMN). In the statement EPA said any person who sub-
mits a PMN under the interim policy and who (after the
90-day period) begins to manufacture or import the new
substance for commercial purposes must inform EPA on
or about the date when manufacture or import com-
mences, so that the Agency can add the substance to the
TSCA Inventory. This reporting requirement is imposed
under section 8(b). Listed below and on the next few
pages are the latest commencement of manufacture
notices EPA has received.
NEW CHEMICAL SUBSTANCES FOR WHICH EPA HAS RECEIVED COMMENCEMENT
OF MANUFACTURE NOTICES
(since publication of the October 1982 Chemicals-in*Progrest Bulletin)
PMN No.
80-110
80-111
Submitter
CBI=Confidential Business
Information
Chemical Identification
G=Generic Name
CBI
Do
FR Citation
Do-Ditto
G 2-((2-Methylsubstituted)ethyloxycarbonyl)substituted) 45 FR 42018
phenyl, disulfo, diheteropolycyclic heteropolycycle	6/23/80
G	Do	Do
3

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80-112 		Do	G 2-((2-Methylsubstituted)ethyloxycarbonyl)substituted)	Do
phenyl, disheteropolycyclic heteropolycycle
80-113 		Do	G 2-((2-Methylsubstituted)phenyl), diheteropolycyclic	Do
heteropolycycle
80-114 		Do	G Dioxoheteropolycyclic), diheteropolycyclic heteropoly-	Do
cycle
80-115 		Do	G (Dioxo, methylheteropolycyclic), diheteropolycyclic	Do
heteropolycycle
80-116 		Do	G (2-Substitutedphenyl), diheteropolycycle hetero-	Do
polycycle
80-295 		Do	G Disubstituted nitrobenzene	45 FR 78791
11/26/80
80-296 		Do	G Ethyl, substituted, ((sulfopropyl) heteropolycyclic)	Do
methyljalkenyl heteropolycycle
80-297 		Do	G Ethyl, substituted, methylheteropolycycle tosylate	Do
80-298 		Do	G Substituted, methyl-heteropolycycle	Do
80-299 		Do	G Disubstituted benzene	Do
80-300			Do	G Bisfnitro, substituted phenyl) substituent	Do
81-71			Ethyl Corp.	G Alkenylpyrolidinedione	46 FR 19075
3/27/81
81-218 		CBI	Adipic acid-dipropylene glycol-linseed oil fatty acid- 46 FR 29524
trimellitic anhydride-trimethylol propane polymer	6/2/81
81-295 		Do	G Acrylonitrile polymer with alkenoic acid alkyl esters, 2- 46 FR 36241
propenoic acid and 2-propenoic acid, 2-methyl	7/14/81
81-298 		Do	G Copolymer of styrene alkyl acrylate, alkyl methacrylate 46 FR 36243
acid with substituted acrylamide	7/14/81
81-315 		Olin Corp.	Propoxylated hydrazines	46 FR 44047
9/2/81
81-337 		Shell Oil Co.	G Epoxy resin modified with substituted organic acid	46 FR 39889
8/5/81
81-342 		CBI	G Benzenedicarboxylic acid, trisubstituted	Do
81-343 		Do	G Benzenedicarboxylic acid, disubstituted	Do
81-383 		Do	Sodium salt of the sulfonated reaction products of 1 - 46 FR 42330
amino-4-(phenylamino)-9,10-dihydro-9,10-dioxo-2- 8/20/81
((3'propanesulfonic acid)oxo)anthracene
81-384 		Do	1-amino-4-phenylamino)9,10-dihydro-9,10-dioxo-2-	Do
(propanesulfonic acid)oxo)anthracene, sodium salt
81-414 		Do	G Polyalkanediol polyurethane	46 FR 45996
9/6/81
81-418 		Do	G Nitropolyhaloalkylbenzenepolyamine	Do
81-437 		Do	G Polynitro polyhalo alkyl aniline	46 FR 47003
9/23/81
81-441 		Do	G Mixed mono and dialkyl-dithio-thiadiazoles	Do
81-485 		Do	G Polymer of a substituted alkanediol, a carbomonocyclic 46 FR 48979
anhydride and a substituted alkanoic ester	10/5/81
81-496 		Do	3-Hydroxy-1-propanesulfonic acid	46 FR 49946
10/8/81
81-543 		Do	3-Hydroxy-1 -propanesulfonic acid, monosodium salt 46 FR 54972
11/4/81
81-574 		Do	G Polyurethane thermoplastics resin	46 FR 56651
11/18/81
81-630 		Do	G Poly(ester)-co-poly-(ether)	46 FR 62312
12/23/81
81-634 		Do	G Protein associated biopolymer	46 FR 62313
12/23/81
81-662			Do	G Substituted propionamide	47 FR 1020
1/8/82
82-1			3M Co.	G Halogenated derivative of polyethylene glycol	47 FR 1409
1/13/82
82-26 		American	G Substituted amine	47 fr 3592
CyanamidCo.	1/26/82
82-30 		CBI	G Polysubstituted alkyl polyamine	47 fr 3591
1/26/82
82-39 		Do	G Polymer of a diisocyanate, polyglycol and polysubsti- 47 FR 4144
tuted alkyl amine	1 /28/82
82-62 		Olin Corp.	G Hybrid urethane	47 fr 5933
2/9/82
82-68 	 Mobay Chemical Co. G Polymer of diphenylmethane diisocyanate and hydroxy 47 FR 6365
alkyl ethers	2/11/82
82-71 		CBI	G Alkyl aryl amino polyol	47 FR 7310
2/18/82
82-136 		Do	G Disubstituted heteromonocycle	47 FR 8840
3/2/82
82-138 		Do	G Trisubstituted phenol	Do
82-145 		Do	G Modified polyester polyurethane from substituted	47 FR 10073
alkanediols, alkanedioic acid and a diisocyanate	3/9/82
82-149 		Do	G Trisubstituted phenol	Do
4

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82-167 		Do
82-178 		Do
82-179 		Do
82-180 		Do
82-209 		Do
82-210 		Do
82-211 		Do
82-212 		Do
82-213 		Do
82-214 		Do
82-221 		Do
82-222 		Do
82-223 		Do
82-234 		Do
82-245 		Do
82-246 		Do
82-249 		Do
82-252 		Uniroyal Chemical
Co.
82-254 		CBI
82-256 		Do
82-257 		Monsanto Co.
82-260 		CBI
82-271 		Do
82-273 		Monsanto Co.
82-284 		FMC Corp.
82-285 		Do
82-286 		CBI
82-287 		Do
82-288 		Do
82-290 		Do
82-291 		Do
82-292 		Do
82-296 		Do
82-301 		Do
82-304 		Do
82-306 		Do
82-308 		Do
82-309 		Celanese Plastics
and Specialties Co.
82-310 		Do
82-311 		CBI
82-312 		Do
82-313 		PPG Industries Inc.
82-320 		CBI
82-321 		E.I. duPontde
Nemours & Co., Inc.
		S.C. Johnson & Son
82-329 		CBI
f? ??? 		Reliance Univeral Inc.
o^-J34 		^n,
82-335 	
82-336 	£
82-337 		Do
82-348 		Spencer Kellogg
		Division of Textron Inc.
82-349 		CB,
82-356 		Do
G Disubstituted benzene
G Disubstituted butanamide
G	Substituted thioic acid ester salt
G	Disubstituted benzene
G	Polymer from disubstituted monocycle and disubsti-
tuted alkanes
G	Disubstituted benzene
G	Disubstituted butanamide salt
G	Disubstituted benzene
G Do
G	Benzoxazole carbocyanine
G Do
G	Do
G Polyester-urethane
G Modified aromatic diisocyanate with aliphatic triol
G Modified polyurethane
G Barium sulfonated red
G Modified hydroxy functional acrylic copolymer
G Isocyanate terminated polyester polyurethane pre-
polymer
G Modified polymer of styrene, alkenoic acid, alkenoic
esters and substituted alkenoic esters
G Poly[(aminoalkylamino)alkylene oxide], aqueous solu-
tion
m-chlorophenylphenylether
G Disubstituted benzene
G Acid blocked amine
m-chlorophenylphenylsulfide
Methylated triphenyl phosphate residue
Isopropylated triphenyl phosphate residue
G Substituted aryl alkyl siloxane
G Disubstituted benzene
G Polymer of disubstituted acrylic acid, disubstituted ben-
zene and substituted acrylic acid
G Disubstituted benzene
G Sulfonated copper phthalocyanine dye
G Substituted trialkyl silane
G 9,10-Anthracenedione sulfonic acid, sodium salt
G Neutralized polymer of styrene, alkyl acrylates and sub-
stituted alkyl methylacrylates
G Quarternary amine functional polyether urethane
modified polyglycidyl ether of bisphenol A
G Disubstituted benzenamine
G Substituted benzotriazole
G Cationic substituted acid amide
G	Do
G Unsaturated alkyl amino alkyl dioxolane
G Dihaloethylacetate
Acetamide-2,2-dichloro-N-(1,3-dioxlan-2-ylmethyl)-
N-2-propenyl
Phenol, 4-nitroso-, magnesium salt, hexahydrate
G Polyester random copolymer
G Styrene acrylate copolymer
G	Poly[(aminoalkylamino)alkylene oxide]
G	Polyacrylate
G	5-Chloro-4-nitro-2-substituted aryloxydimethylaniline
G	5-Chloro-2-substituted aryloxyaniline
G	2-Chloro-4(N,N-dimethylamino)-5-substituted aryloxy-
diazonium tetrafluoroborate
G	5-Chloro-2-substituted aryloxydimethylaniline
G	Urea/carbamate elastomer
G Polycyclic sulfonic acid salt
G Polymer of 1,4-benzenedicarboxylic acid dimethyl
ester; dihydroxyalkane; 1,6-hexanediol; alpha hydro-
omega hydroxy poly (oxy-1,4-butanediyl)
4 7 FR 10900
3/12/82
47 FR 11957
3/19/82
Do
Do
47 FR 13037
3/26/82
Do
Do
Do
Do
Do
47 FR 14220
4/2/82
Do
Do
47 FR 15406
4/9/82
47 FR 16403
4/16/82
Do
Do
Do
Do
Do
Do
Do
Do
Do
47 FR 17666
4/23/82
Do
Do
47 FR 18652
4/30/82
Do
Do
Do
Do
Do
Do
Do
47 FR 19781
5/7/82
Do
Do
Do
Do
Do
Do
Do
Do
47 FR 20852
5/14/82
Do
Do
Do
Do
Do
Do
47 FR 22214
5/21/82
Do
Do
5

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82 369 	 Goodyear Tire & G Benzenedicarboxylic acid saturated mixed glycols co-	47 FR 23552
Rubber Co. polyester	5/28/82
82-370 	 Do G Do	Do
82-373 	 Do G Poly(ester-urethane)	Do
82-375 	 Quaker Oats Co. Formaldehyde polymer with 2-furanmethanol and	Do
methyloxirane capped
82-377 	 01 in Corp. G Hybrid urethane	Do
82-382 	 CBI G Polymer of alkenoic acid alkyl esters, 2-propenoic acid,	47 FR 25400
and 2-propenoic acid, 2-methyl	6/11/82
82 383 	 Do G Brominated xylenol	Do
82-384 	 Do G Bis[bromoxylenol]sulfide	Do
82-385 		Do	G Bis[zylenol]sulfrde
82-392 	 Do G Hydroxy ethyl ester substituted polybis imide of	Do
pyromellitic dianhydride
82-396 	 Do G Substituted oxirane reacted with polyalkylene glycol	Do
82-400 	 Jordan Chemical Co. Potassium N, N-bis(hydroxyethyl) cocoamine oxide	Do
phosphate
82-408 	 Hach Co. G Tetra tosylate porphine	47 FR 25401
6/11/82
82-409 	 Jordan Chemical Co. Postassium N.N-bis(hydroxyethyl) tallow amine oxide	Do
phosphate
82-412 	 CBI Anthral[2,1,9-def:6,5,10-d'e'f]diisoquinoline-1,2,8,	Do
10(2H, 9H)-tetrone, 2,9 bis(4-aminophenyl)
82-429 	 Do G Ethoxylated molybdenum amine	47 FR 26234
6/17/82
82-435 	 Do G Poly[oxy(methyl-1,2-ethandiyl)] aliphatic ether amide	47 FR 27610
of dialkenoic acid	6/25/82
82-438 	 Do G Aromatic amine ester	Do
82-439 	 Hach Co. G Sulphonated phenyl arsine dibromide	Do
82-452 	 CBI G Benzoxazole oxazolidinone	47 FR 28994
7/2/82
82-453 	 Do G Benzoxazolium salt	Do
82-464 	 Do G 2-Hydroxyl-3-naphthoic acid N-aryl amide	47 FR 30103
7/12/82
82-480 	 Do G Polyol polyacrylate	Do
82-481 	 Do G Blocked urethane polymer	47 FR 31063
7/16/82
82-486 	 Do G Alkyl phosphate ester	Do
82-489 	 The Southland Co. G Sulfurized di-cacboxylic polyglycol ester	47 FR 31956
7/23/82
82-502 	 CBI G Substituted diazo compound	47 FR 33234
7/30/82
82-503 	 Do G Water base vinyl acrylic copolymer	Do
82-527 	 E.I. duPont de G Titanium (4+) mixed alcohol complex	47 FR 34187
Nemours & Co.	8/6/82
82-535 	 Coastal States G Modified phenol formaldehyde substituted alkylamine	Do
Chemical Co.
REGULATION OF HAZARDOUS SUBSTANCES . . . SECTION 6
Under section 6, EPA is authorized to control a chemical
as a hazardous substance if the Agency finds that the
chemical will present an unreasonable risk of injury to
PCB Background
Under section 6(e), EPA is required to control the manu-
facturing, processing, distribution in commerce and use
of polychlorinated biphenyls (PCBs). On May 31, 1979
EPA promulgated a PCB rule. However, on October 30,
1980, the United States Court of Appealsforthe District
of Columbia Circuit, responding to a petition filed by the
Environmental Defense Fund, set aside that portion of
the PCB rule that characterized intact nonleaking PCB-
containing transformers, capacitors and electromagnets
as totally enclosed. The court also struck down the pro-
vision limiting application of the rule to PCBs in concen-
trations of 50 ppm or greater for manufacturing, pro-
cessing, distribution in commerce and use. The court
remanded both parts of the May 31,1979 rule to EPA for
further action.
EPA Amends PCB Rule
EPA has published a final rule excluding the production
human health or the environment. Under 6(aj, EPA is
requiredto apply one or several requirements of the law
to the extent necessary to protect against the risk.
of PCBs in closed and controlled waste manufacturing
processing from section 6(e) of TSCA. This rule replaces
portions of the May 31,1979 rule, which generally pro-
hibits the manufacture, processing, distribution in
commerce and use of PCBs.
The October 21,1982 rule (47 FR 46980) excludes those
manufacturing processes from the section 6(e) ban that
produce PCBs as a byproduct and impurities, as long as
the PCBs released into the air, water or contained in
products or wastes do not exceed limits stated in the
rule. These limits represent the lowest concentrations
of PCBs that can be practically quantified.
Although PCBs are no longer being manufactured as a
product, many fundamental chemical processes gener-
ate PCBs in low concentrations as impurities or bypro-
ducts. PCBs can be produced in chemical reactions
involving chlorine, hydrocarbons and heat,
6

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The final rule modifies and clarifies some of the pro-
posed requirements set forth on June 8, 1982 (47
24976). The changes were made because of informa-
tion obtained during the comment period and at t e
public hearing on the proposed rule.
In the proposed rule EPA defined the absence of 'n
releases from closed and controlled waste manufactur-
ing processes by referencing an analytical technique, in
the final rule EPA set numerical cutoffs for purposes o
defining the absence of PCBs in such releases.
In the proposed rule EPA defined conlroHed waste as
wastes disposed of in facilities approved by EP" or
disposal of PCB wastes under 40 CFR 761.60, (par o
the May 31, 1979 rule on PCBs). In the final rule trA
added additional mechanisms, including some Resour e
Conservation and Recovery Act (RCRA) approved in i
erators, for the disposal of controlled wastes containi g
PCBs in concentrations between the limit quantita 10
and 50ppm. In the final rule EPA said it was institutingia
new reporting requirement in addition to the recor
keeping requirements set forth in the proposed ru e.
In addition, the rule requires that manufacturers dispos
ing of controlled wastes in RCRA-approved incinera o
certify that the incinerator is capable of <^	H
readily burned compounds than the PCBs to
stroyed, and that the incinerator when burning
will be operated under conditions shown to resu i
destruction of less readily burned compounds.
EPA Denies GE Petition
EPA has denied a citizen's petition from the G®"®1"®'
Electric Co. (GE) to amend the PCB rule to
monochloro biphenyls (MCBs) and dichloro biphieny
(DCBs). EPA said the GE arguments about relativeirisks
of the two substances may have some techmca >
but the Agency said that it would be addressing
arguments in the rulemaking that will cover un
trolled manufacture of PCBs. If GE felt it was still neces-
sary, GE could resubmit the petition "after this major
rulemaking is completed," EPA said.
On July 14,1982 GE said in its petition MCBs and DCBs
are not persistent in the environment and do not 103
cumulate because they are rapidly metabolize ®
eliminated from the body. GE also said the health e,tecI
°f chlorobiphenyls, especially the lesser chlorina e
MCBs and DCBs, are minimal and their exclusion from
the PCB rule would be consistent with Congressional
intent. GE also said the exclusion would be consistent
with the PCB definition used by Canada and the Euro-
pean Economic Community. Finally GE said
would have a significant economic impact on GE. I
denial of the GE petition was issued on October 20,
1982 (47 FR 46723).
REPORTING RULES
SUBSTANTIAL RISK	SECTION 8(e)
Under section 8(e) persons who obtain information
which reasonably supports the conclusion that a sub-
stance presents substantial risk of injury to fiuman
health or the environment-must notify EPA within i
days. These notices are then reviewed by OTS and an
initial evaluation is prepared containing, if appropriate,
follow up questions to the submitter, referrals to other
agencies, and recommended OTS/EPA followup ac-
tions. The 8(e) notices represent a company's first
revie wofa situation and a judgment in compliance with
the statute to submit a notice within 15 days of obtaining
the information. EPA published its evaluations of these
notices to make this section 8(e) information widely
available and understandable to a broad public. The
submissions and the initial evaluations are located in
the OPTS Public Reading Room, first floor. East Tower,
Waterside Mall, 401 M Street, SW, Washington, D.C.
Persons wishing to obtain a copy of section 8(e) notices
may write: Ms. Jerri Green, EPA (A-101), Washington,
D.C. 20460. There is no charge for duplicating the first
49 pages, but at page 50 of a request for duplication
there is a $10.00 fee and a 200 charge for each addi-
tional page (e.g., 51 pages cost $10.20).
Recent Section 8(e) Notices of Substantial Risk
Log No. 8EHQ	[CAS NO}
0882-0452
4-Chloro-3-nitroaniline	635-22-3
Summary results from a short term feeding study
0882-0453
Ethylene oxide	75-21-8
Preliminary summary results of a chronic inhalation study
0882-0454
Pentaerythritol triacrylate	3S24-68-3
Pentaerythritol diacrylate	53417-29-1
Pentaerythritol tetraacrylate	4986-89-4
Final results from a chronic skin-painting study
0982-0455
Oil yellow E 190	2481 -94-9
Solvent Red 19	6368-72-5
Final results from an in vitro battery of genetic screening
tests
0982-0456 S
Gulf TS-905-HWCF Concentrate
Preliminary results from (an) acute eye irritation test
0982-0457
Miscellaneous organic chemicals
Preliminary analytical results from a study of groundwater
contamination
0982-0458
Bis (2,3-dibromopropyl ether) of	21850-44-2
tetrabromobisphenol A
Final results from several mutagenicity tests
1082-0459
Oipropyleneglycol diacrylate
Summary results from acute eye/skin irritation studies
1082-0460
Pentaerythritol monooleate triacrylate
Summary results from a battery of short term in vitro tests
1082-0461
Chlorinated toluenediamine
Report of a chronic feeding study.
S at the end of Log Number means a sanitized version is available.
N.B.: All toxicity, oncogenicity, teratogenicity and mutagenicity studies involve
animals unless otherwise stated. Additional tests (e.g., bacterial cell) ere noted or are
included in the term "battery."
SUPPORT ACTIVITY
GPO Reprints Cumulative Supplement II
The Government Printing Office (GPO) has reprinted the
TSCA Cumulative Supplement II (CSII). GPO sold out the
first printing of 2,518 copies, which went on sale in late
7

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June. The more than 900-page book is being sold by
GPO for $17 a copy. For shipment outside the United
States the charge is $21.25.
CSII, when combined with the TSCA Initial Inventory of
Chemical Substances, published in May 1979, consti-
tutes the TSCA Revised Inventory of Chemical Substan-
ces. CSII supersedes both Supplement I and Cumulative
Supplement I, published by EPA in 1979 and 1980
respectively. There are now over 58,000 chemical sub-
stances on the TSCA Revised Inventory.
To order CSII from GPO checks should be sent to: Super-
intendent of Documents, GPO, Washington, D.C. 20402.
The GPO document number for CSII is No. 055-000-
00218-5. GPO will accept Master Charge or Visa credit
card telephone orders. The GPO order desk number is
(202) 738-3238.
CSII is also available on microfiche from the National
Technical Information Service (NTIS), 5285 Port Royal
Rd., Springfield, Va. 22161.The NTIS document number
for CSII is PB 82-203290. NTIS will also accept credit
card telephone orders. The NTIS order desk number is
(703) 487-4650. CSII costs $11.50 in microfiche for
shipment within the United States and $23 for shipment
elsewhere.
Section 8(d) Booklet Available
The IAO has a new booklet containing the most fre-
quently asked questions, and EPA's answers, about
reporting under the TSCA section 8(d) health and safety-
rule. Also included in the booklet is a partial list of
chemical categories and members of the categories
named in the 8(d) rule, which became final on Sep-
tember 2, 1982. The rule requires manufacturers and
processors to provide EPA with unpublished health and
safety information about specific chemicals. The health
and safety information will aid EPA's investigation of
risks posed by specific chemicals and categories of
chemicals.
Existing Chemicals Paper Available
A paper describing how the TSCA existing chemicals
program is being managed is now available. The objec-
tives of the existing chemicals program are explained,
which include further evaluation of chemicals after test-
ing in compliance with section 4 has been completed.
The paper is a supplement to the January 1982 "Priori-
ties for OTS Operations" report.
EPA Samples Submitter-Sanitized PMNs
EPA recently performed a spot check of submitter-
sanitized PMNs. In a sampling of 50 notices received in
October 1982, 21 notices contained one or more confi-
dential business information (CBI) items which were not
claimed CBI by the submitter. Many of the missed CBI
claims could have been caught by the submitter through
a more careful checking of the notice prior to filing with
EPA.
The most frequently missed CBI claims found in
submitter-sanitized PMNs are:
Inadvertent CBI linkage
Chemical identification
Production volume
Use
Inconsistency in CBI
claims
Incomplete company-
sanitized claim
Linkage to previously
submitted PMN
Generally manufacturer identifica-
tion, such as site or company per-
forming toxicity tests, authorizing
official name left on document
Parts of chemical identification left
in process and/or exposure infor-
mation
Amounts discussed in exposure or
risk assessment which link it to
production volume
Improper masking or none at all on
Federal Register page
Same claims not masked through-
out the PMN
Company-sanitized package con-
tains: sanitized PMN, unsanitized
attachments: unsanitized PMN,
sanitized attachments
Reference a previously submitted
PMN which contained CBI not
claimed CBI in current submission,
or non-CBI data could disclose the
nature of CBI claims in previous
submission
Industry Assistance Office (TS 799)
Office of Pesticides & Toxic Substances
U.S.E.P.A.
Washington, D.C. 20460
Official Business
Penalty for Private Use
$300
First Class Mail
Postage and Fees Paid
EPA
Permit No G 35
THE TSCA CHEMICALS IN PROGRESS BULLETIN

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