Vol. 4, No. 4 August 1983 This news bulletin is intended to inform all persons concerned with the Toxic Substances Control Act (TSCA) about recent developments and near-term plans. For further information or to request copies of documents mentioned, write the TSCA Assistance Office (TAO), (TS-799) EPA, Washington, D.C. 20460, or call toll-free 800-424-9065 or, in Washington, D.C., or from outside the continental United States, (202) 554-1404. REGULATORY & REQUIRED ACTIONS TESTING OF CHEMICAL SUBSTANCES AND MIXTURES ... SECTION 4 Section 4 of TSCA gives EPA authority to require manu- facturers or processors of chemicals to test the toxic ef- fects of a designated substance. To require testing EPA must find that the chemical may present an unreasona- ble risk; that there are insufficient data available with which to perform a reasoned risk assessment; and that testing is necessary to generate such data. A test rule may also be based on an EPA finding of substantial pro- duction and exposure to humans or the environment, in addition to findings of insufficient data and need for testing. Under section 4(e) an Interagency Testing Committee (ITC) was established to recommend chemicals to EPA for priority consideration. The ITC can designate up to 50 chemicals or categories of chemicals for testing and EPA must respond within one year by starting rulemak- ing under section 4 or giving reasons for not doing so. Section 4(f) TSCA requires EPA within 180 days after re- ceipt of test data or other information that indicates a chemical substance or mixture may pose a significant risk of serious or widespread harm to human beings from cancer, gene mutations or birth defects to: a) initi- ate appropriate action under sections 5, 6, or 7 of TSCA or b) publish a notice saying why the risk is not unrea- sonable. The 180-day review may be extended for up to 90 additional days for good cause. Section 4 Rule Proposed for MO On July 5, 1983 EPA proposed a section 4 rule to require manufacturers and processors of mesityl oxide (MO) to test the chemical for various health effects (48 FR 30699). The tests proposed to be required involve chronic toxic- ity (with an emphasis on blood disorders) and mutage- nicity. If positive results are obtained in the mutagenic- ity tests, then EPA proposes that MO also be tested for oncogenicity. In the July 5, 1983 notice, EPA responded to the June 1, 1979 ITC designation of MO for priority testing consideration including carcinogenicity, muta- genicity, teratogenicity, other chronic health effects and epidemiology studies. The proposed rule does not include an epidemiology study because EPA believes that no end point has been sufficiently well-defined to make an epidemiology study worthwhile at this time. EPA also did not propose that MO be tested for teratogenicity because there is no evi- dence to suggest the chemical produces teratogenic effects. Persons wishing to submit oral or written comments on this proposed rule should call or write the TAO for full details. EPA will hold a public meeting on the proposed rule on September 19, 1983, in Washington, D.C., if there is public interest in doing so. 4,4'-Methylenedianiline Under Accelerated Review On July 11, 1983 (48 FR 31806) EPA said it is not initiat- ing rulemaking at this time under section 4(a) to require health effects testing of 4,4'-methy!enedianiline be- cause it received data from a recent study that show the chemical to be a carcinogen in both rats and mice. The data EPA received are from a recently completed Na- tional Toxicology Program (NTP) 2-year carcinogenicity study. Based on the NTP data, EPA, under section 4(f) 1 ------- authority, initiated on April 27, 1S83 (48 FR 19078) a 180-day review of the chemical and said in the July 11, 1983 notice it doss not believe data obtained from testing for other health effects are likely to change the regulatory decisions lhat will be based on the NTP information. On June 1, 1979 (44 FR 31866) 4,4'-methylenedianitine had been designated by the ITC for priority considera- tion under section 4(e). The July 11, 1983 notice was EPA's response to the ITC recommendation, EPA Propose* Cresols Health Effacts Testing EPA has proposed to require manufacturers and processors of cresols to test these chemicals for certain health effects. If the rule becomes final, the cresols tests would be for carcinogenicity, mutagenicity, terato- genicity, reproductive effects, neurotoxicity, skin sensi- tization and subchronic toxicity. The proposed rule is EPA's response to the ITC designation of cresols as pri- ority candidates for testing for certain haafth effects. In its designation of cresols, the ITC included testing for environmental effects, specifically chronic effects in fish and aquatic organisms [October 12, 1977 (42 FR 55026)1. EPA in its notice [July 11, 1983 (48 FR 21812)1 did not propose any additional environmental effects testing, EPA said information is available for it to rea- sonably predict that exposure of aquatic organisms to cresols should not cause chronic effects. However, the EPA decision not to tast for environmental effects is a preliminary decision and the Agency is specifically re- questing comments on that decision. If comments are such that EPA decides thai environmental effects testing is required, then chronic effects testing for aquatic vertebrates and invertebrates (fresh water and salt water) will be required in the final rule. Written comments should be sent Dn or before September 8, 1983 to: OPTS-42Q32 (DCNI TSCA ITS-793) E-108 Washington, D.C. 20460 EPA will hold a public meeting on the proposed rule on September 28, 1983 in Washington, D.C. Persons wishing to submit oral comments on the proposed rule should call or write the TAO for full details. 4-CBTF Negotiated Test Program Stands EPA has found [July 18, 1983 148 FR 32730)) no reason to alter a 1982 decision not to initiate rulemaking under section 4(a) to require environmental or health effects testing of 4-chlorobenzotrifluoride (4-CBTF). The No- vember 8, 1982 preliminary decision {47 FR 50S5S) was made pending consideration of public comments on a testing proposal submitted to EPA by Occidental Chem- ical Corporation, the sole U.S. manufacturer of 4-CBTF. EPA said the 1982 negotiated testing program, since modified to respond to techncia) comments, would pro- vide sufficient data to reasonably determine or predict the health and environmental effects of 4-CBTF. The chemical had been designated by the ITC in its 9th Re- port, for health and environmental effects testing consideration. Data Reimbursement Rule Made Final A final rule setting forth methods of determining fair amounts for data reimbursement and for resolving dis- putes arising over allocation of the costs of testing re- quired by a section 4(a) test rule was published on July 11, 1983 (48 FR 31786). This rifle potentially affecls all persons subject to a test rule under section 4(a). How- ever, EPA believes that in most cases companies sub- ject to a test rule will be able to work out voluntary cost sharing arrangements. When parties cannot agree, TSCA requires EPA 10 order fair and equitable reim- bursment. The final rule provides for an independent hearing officer to propose an order after an informal hearing resembling commercial arbitration. The rule also contains guidelines for the hearing officer's deci- sion, suggesting that in most cases test costs and toe fairly apportioned on the basis of market share. The proposed order of the hearing officer may be appealed to the Agency, and to a Federal district court. COMMENCEMENT OF MANUFACTURE NOTICES . .. SECTION 5 Under section 5(a)(1) a person who intends to introduce into commerce a chemical substance not on the TSCA Inventory must notify SPA st least SO days before be- wuiure nonces tfA has received. NEW CHEMICAL SUBSTANCES FOR WHICH EPA HAS RECEIVED COMMENCEMENT OF MANUFACTURE NOTICES (•Idea puhltcMlon of th« M«y 1*»S Bulletin I ginning manufacture or import. Listed below end on the next few pages ere the latest commencement of manu- facture notices SPA has received. PMN no. Submitter CBI«Confld*nlial Buaineat Information Chemical Identification 80-221 E.I, du Pont de Nemours & Co,, Inc. 80-222 CBI 80-347 Do 80-365 Monsanto Co. 81-58 CBI 81-89 Shell Oil Co. e=Q9tiBftc Nam* G G Cyclohexane csrbonitrilo, 1,V-azobis Cyclohexana carboniuile, 1-amino Metal amine propanol complex Calcium sodium ethylenediemlne tetrakis (methylene phosphate) Phenolic novalak resin Epoxy resin/substituted amine adduct FR Citation Do-Ditto 45 FR 62195 9(18/80 Do 46 FR 11026 2/5/81 46 FR 6080 * 1/19/81 46 FR 16933 3/16/81 46 FR 20763 4/7/81 ------- 81-154 CBI G Alkyl epoxide, reaction products with inorganic 46 FR 24681 acid 5/1/81 81-191 Do Acrylic acid, bisphenol A-epichlorohydrin resin. 46 FR 28004 ethyl acrylate, methyl methacrylate, polyvinyl 5/22/81 butyral resin and styrene polymer 81-256 American Cyanamid Co. G Poly (2-hydroxypropyl) 46 FR 35345 81-308 monoheterocyclictriazmine 7/8/81 CBI G Complex of mixture of 4,4'-dihydroxyphenyl sul- 46 FR 37966 fone and 2,4-dihydroxyhenol sulfone and an 7/23/81 81-310 alkylamine Do G Modified phenolic novolak resin Do 81-336 Do G Ester of hydrozamic acid 46 FR 39889 8/5/81 81-352 Celanese Plastics & Special- G Epoxy urethane copolymer 46 FR 39885 ties Co. 8/5/81 81-392 CBI G Trialkoxysilylalkyl acrylamine 46 FR 44046 9/2/81 81-428 Do Substituted heteromonocyclic derivative of a 46 FR 45807 substituted thioxantheno isoquinoline. 9/15/81 phenylpyrazol-3-ene-5-one [2,3-b] thioxan- theno[2,1,9-d,e,f] isoquinolin-7-one 81-445 Sherwin-Williams Co. Polyglycidyl-m-xylenediamine 46 FR 47003 9/23/81 81-465 CBI G Alkanedioic acid, (1-methyl, 5-hydroxymethyl 46 FR 47855 heteromonocycle) diester 9/30/81 81-466 Do G Alkanedioic acid, bis(hydroxymethyl Do heteromonocycle) ester 81-571 Day-Glo Color Corp. Benzo(k.l.) thioxanthene 3,4-dicarboxylic 46 FR 56038 anhydride 11/13/81 81-638 CBI G Polyether reaction product with toluene 46 FR 62687 diisocyanate-methacrylate terminated 12/28/81 82-6 American Color and Chemical G (Dialkylaminophenylazo) azobenzene sulfonic 47 FR 2399 Corp. acid 1/15/82 82-22 Celanese Plastics & Special- G Acrylic copolymer 47 FR 3592 ties Co. 1/26/82 82-64 Do G Polyamide-acrylic resin 47 FR 6363 2/11/82 82-84 CBI G Alkylthio metallic mercaptan 47 FR 7753 2/22/82 82-188 Do G Modified polymer of alkenoic acid, alkenoic ester 47 FR 11957 and substituted alkenoic esters 3/19/82 82-203 Do G Bisphenol A-epichlorohydrin resin-mixed acrylic 47 FR 13037 polymer 3/26/82 82-239 Do G Substituted unsaturated alcohol 47 FR 15406 4/9/82 82-240 Do G Do Do 82-271 Do G Acid blocked amine 47 FR 16403 82-284 4/16/82 FMC Corp. Methylated triphenyl phosphate residue 47 FR 17666 82-316 4/23/82 Texaco Chemical Co. 4-Butylmorpholine 47 FR 19781 82-352 5/7/82 CBI G Naphthalenedisulfonic acid, [[aminosulfohydroxy 47 FR 22214 82-353 Do napthalenyl] azo]-, trisodium salt 5/21/82 G Substituted phenyl-pyrimidine Do 82-354 Do G Do Do 82-363 Monsanto Co. G Polyoxypropylene ester acyl caprolactam 47 FR 23552 82-368 Do 5/28/82 G Alkenyl alkyl siloxane alkoxy terminated Do 82-399 CIBA-GEIGY Corp. C10-,«-alkyl mercaptoacetates reaction products 47 FR 25401 with dichlorodioctylstannane and 6/11/82 82-410 CBI trichloroctylstannane G Substituted heterocycle, amine salt Do 82-414 E.I. du Pont de Nemours & G Polyester polymer Do Co., Inc. 82-416 Do G Urethane polyol Do 82-424 CBI Polymer of hexanediol, dantocol, trimethylo) 47 FR 26234 82-427 Diamond Shamrock Corp. propane, isophthalic acid, adipic acid 6/17/82 G Alkoxylated aliphatic glycol Do 82-428 Do G Acrylated alkoxylated aliphatic glycol Do 82-432 Sanofi Inc. Reaction mixture containing: isobomyl 47 FR 27610 acetylacetate, iaobornyl acetate and ethyl 6/25/82 82-442 CBI acetylacetate G Aromatic acids, polyether polyol alkyd 47 FR 27610 82-522 Do 6/25/82 G Diureldo silane ester 47 FR 34187 8/6/82 3 ------- 82-525 Do G 82-529 Do G 82-531 Do G 82-532 Do G 82-545 Do 82-550 Atlantic Chemical Corp. G 82-551 Do G 82-552 Do G 82-553 Do G 82-554 Do G 82-556 Do G 82-612 3M Co. 82-613 Do 82-614 Do 82-615 Do 82-616 Do 82-617 Do 82-618 Do 82-619 Do 82-620 Do 82-621 Do 82-622 Do 82-623 Do 82-624 Do 82-625 Do 82-626 Do 82-633 CBl 82-639 Calgon Corp. 82-646 CBl 82-652 Sandoz Colors 8t Chemicals 82-655 American Cyanamid Co. 82-664 CBl 82-665 Do 82-668 Sherex Chemical Co. 82-677 CBl 82-681 Do Polyester modified epoxy resin Aliphatic acid ester salt Organophosphorus compound Do Polymer of hexane, 1,6-diisocyanato-, homopolymer, 2-butanone, oxime Sulfoaryl disazo substituted naphthalenesulfonic acid, salt Do Do Do Do Do Mixed C5-C,s perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 25°-35° Mixed C5-C,a perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 35°-50° Mixed C6-C,a perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 50°-60° Mixed C5-C,„ perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 60°-75° Mixed C5-CnB perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 75°-90° Mixed C5-C1B perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 90°-105° Mixed C5-C,B perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 105°-120° Mixed C5-C1B perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 120°-140° Mixed C5-C10 perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 140°-165° Mixed C5-C18 perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 165°-180° Mixed C5-C1B perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 180°-190° Mixed C5-C1B perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 190°-200° Mixed C5-C,„ perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 200°-220° Mixed C5-C,B perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 220°-235° Mixed C5-C1B perfluorinated hydrocarbons, ethers and tertiary amines, characterized by boiling point range 235°-255° G Fatty secondary amide G G G G G Polyacrylate copolymer Cobolt complex-t(hydroxynitrophenyl-azo-)- (substituted)phenyl pyrazolones] sodium salt Metal complex substituted aromatic salt Substituted acrytamide copolymer 4-Hydroxy-N-substituted-3- nitrobenzenesulfonamide 3-Amino-4-hydroxy-N-substituted benzenesuifonamide Poly (oxy-1,2-ethane diyl) alpha-C,s-C,» alkyloxy omega methoxy Chromium complex of a substituted phenolazo- phenylpyrazolone Chromium complex of a sulfonaphthylazo- phenylpyrazolone Do Do Do Do 47 FR 35332 8/13/82 Do Do Do Do Do Do 47 FR 39241 9/7/82 Do Do Do Do Do Do Do Do Do Do Do Do Do Do 47 FR 39884 9/10/82 Do 47 FR 41165 9/17/82 Do Do 47 FR 42151 9/24/82 Do Do 47 FR 43160 9/30/82 Do 4 ------- 82-684 82-686 82-697 83-12 83-17 83-47 83-52 83-53 83-54 83-55 83-58 83-59 83-60 83-68 83-72 83-77 83-78 83-82 83-83 83-84 83-85 83-94 83-96 Do Do Do Do Do Ashland Chemical Co. CBI Do Do Do Do Do Do Do Do Do Do 83-79 Do 83-80 Do 83-81 Do Do Do Do Do Do Do G Halogenated hydrocarbon Disubstituted 1-naphthol G Alkyl spirodecane G 2,7-Naphthalenedisulfonic acid, 4-amino-3-[[4-[[4- [(2,4-diamino-5-methylphenyl)azo]phenyl] substituted]phenyl]azo]-5-hyroxy-6- (substituted phenyijazo-, sodium salt G Fatty acids, substituted aromatic esters, alkali metal salts G Polymer of acrylic acid and acrylic esters Reaction product of N,N' 2-tris(6-isocyanatohexyl) imidodicarbonic diamide with 3- (trimethoxysilyl )-1 -propanethiol Cobalt complex of substituted phenolazophenyl- acetacetamide Iron complex of substituted phenolazoresorcinol Substituted alkanediol Bis(((substituted pyrazolyl)azo) substituted phenol)metallate and bis(((substituted pyrazolyl)azo) substituted phenol) metallate, in- organic salts Acrylic acid, polymer with vinyl acetate, acrylate esters and substituted ethylene Metal complex of methylsubstituted-((substi- tuted-hydroxyphenyl)azo)-oxo-dihydro-1H-pyrazole and substituted-((naphthyl)azo)-2-naphthol, and metal complex of methyl-substituted- ((substituted-hydroxyphenyl)azo)-oxo-dihydro-1H pyrazole and substituted-((naphthyl)azo)- 2-naphthol, inorganic salts Alkylated isopropylbenzene G G G G G G G G Benzoquinolinyl-sulfoindenedione Bis(((substituted propanyDazo) substituted phenoDmetallate, plus bis (((substituted propanyDazo) substituted phenol) metallate, in- organic salts Metal complex of ((substituted phenyDazo) sub- stituted phenol and ((aryl)azo) substituted phenol plus metal complex of ((substituted phenylazo)substituted phenol) and ((aryl)azo)- substituted phenol, inorganic salts Metal complex of ((substituted phenyDazo) naphthol and ((substituted naphthyDazo) naphthol plus metal complex of ((substituted phenyl)azo)naphthol and (substituted naphthyl)azo)naphthol, inorganic salts BisU(aryl)azo) substituted phenoDmetallate plus bis(((aryl)azo) substituted phenoDmetallate, in- organic salts Metal complex of ((substituted phenyl)azo)- substituted phenol and ((substituted pyrazolyl)azo)-substituted-benzenesulfonic acid, plus metal complex of ((substituted phenyl)azo)-substituted phenol and ((substi- tuted pyrazolyl)azo)-substituted-benzenesul- fonic acid, inorganic salts Bis(((substituted pyrazolyl)azo)benzoic acid)metallate plus bis(((substituted pyrazolyl) azo)benzoic acid)metallate, inorganic salts Bis(((substituted aryl)azo)-substituted phenoDmetallate, and bis (((substituted aryl)azo)-substituted phenoDmetallate, inorganic salts Bi8((aryl(azo-substituted-phenol) metallate, and bis(((aryl)azo)-substituted phenol-metallate, and bis(((substituted aryl)azo)-substituted- phenoDmetallate, inorganic salts BisHlsubstituted aryDazo-substituted phenoDmetallate, and bis(((substituted aryl)azo)-8ubstituted phenoDmetallate, inorgan- ic salts Alkyl substituted salicylaldehyde ((Substituted phenyl)azo)benzene sulfonic acid, aminium salt Do Do 47 FR 44608 10/8/82 47 FR 46371 10/18/82 Do 47 FR 49072 10/29/82 Do Do Do Do Do Do Do 47 FR 50338 11/5/82 Do 47 FR 52220 11/19/82 Do Do Do Do Do Do Do Do Do Do 5 ------- 83-99 83-112 83-113 83-114 83-118 83-120 83-124 83-237 83-255 83-265 83-266 83-268 83-283 83-284 83-297 83-317 83-320 83-321 83-328 83-330 83-338 83-344 83-345 83-355 83-356 83-357 83-362 83-363 83-365 83-366 83-368 83-373 83-375 83-376 83-377 83-378 83-379 83-386 83-390 83-391 Do American Hoechst Corp. Do Do Celanese Plastics & Special- ties Co. Martin Marietta Corp. American Hoechst Corp. CBI G CIBA-GEIGY Corp. G CBI G Do G Do G Do G Do G Do G Do G Do G Do G Do G Do G Do G Do G Do G Do G Do G Essex Specialty Products, Inc. G Do Do CBI Nalco Chemical Co. Do E.l.duPont de Nemours & Co. CBI Do Do Do Do Do Do Do G G G G G G Sulfonide phenol formaldehyde condensation polymer Hydroxy naphthalenedisulfonic acid, disodium salt, ((sodium sulfooxyethyl) sulfonyUphenyl)- azo and dichlorotriazinylamino substituted Benzenesulfonic acid, 4-(4-((4-substituted 2-sulfophenyl)azo) 3-carboxy-5-hydroxy-1 H- pyrazol-1-y!)-, x, sodium salt Naphthalenedisulfonic acid, disodium salt, ((2-((sodium sulfooxyethyl)=sulfonyI)aryl)azo, and monochlorotriazinylmino, substituted, = copper complex Polymeric polyamidoamine Reaction product of isomeric mixture of dioxocarbopolycyclic amine with sulfur 3-Bromo-4-(4-(bis-2-hydroxyethylamino)-2- methyl-= phenylazo)-5-nitrobenzoic acid ethyl ester Substituted pyridine Dicarboxylic acid monoester Substituted alkyl polyalkytene oxy quaternary ammonium chloride compound Poly(oxyalkyldisubstituted silane) alkyl, alkoxy- terminated, polymer with titanium alkoxide Azobis-(nitrosulfophenyl-alkylsulfobenzene) com- pound with oxyalkylamine Substituted cyclosiloxane Polyester polyol (Substituted) anthracenylimino-(substituted) carbomonocyclic acid alkylamine salt Modified polyester polyurethane from substituted alkanediols, alkandioic acid, and a diisocyanate Polymeric acrylates Mixed glycol oligoesters of mixed dicarboxylic acids Modified copolymer of alkenoic esters and substi- tuted alkenoic esters with styrene Substituted phenate Substituted-1,8-triphenodioxazinedisulfonic acid, sodium salt Mercapto-substituted, heterocyclic nitrogen com- pound Alkyl thiocyanate Substituted aromatic secondary naphthalene amine Substituted 1-aminoanthraquinone-2-sulfonic acid alkali metal salt Isocyanate functional polyurethane derived from reaction of diisocyanate, polymeric ether glycols, polymeric aliphatic polyester glycols Vinyl acrylic copolymer Acrylic grafted copolymer Aromatic methylurea An aqueous solution of ammonium acrylate Disubstituted benzenesulfonic acid alkali metal salt Substituted polyurea Substituted benzene Spiro[2H-1-benzopyran-2,2'-(2H)] indole, 1',3'- dihydro-1 ',3',3'-trimethyl-6,8- dinitro- Do Methyl-methyleneimidazole derivative of copper phthalocyanine, compound with acetic acid Methyl-methyleneimidazole derivative of copper phthalocyanine, compound with methoxy-acetic acid. Disubstituted 4-amine-5-hydroxy-2,7- naphthalenesulfonic acid, alkali metal salt Polyester-imide resin Disubstituted bis(phenylazo)4-amino-5- hydroxy-2, 7-naphthalenesulfonic acid alkali metal salt Do 47 FR 52222 11/19/82 Do Do Do Do 47 FR 53782 11/29/82 Do 47 FR 54537 12/3/82 47 FR 55422 12/9/82 47 FR 57332 12/23/82 Do Do Do Do 47 FR 57336 12/23/82 Do 48 FR 72 1/3/83 Do Do 48 FR 862 1/7/83 Do Do 48 FR 1819 1/14/83 Do Do Do Do 48 FR 3045 1/24/83 Do Do Do Do Do Do Do Do Do Do Do 6 ------- 83-392 Do 83-398 R.T. Vanderbilt Co. Inc. 83-424 CBI G 83-429 Rhone-Poulenc Inc. G 83-437 CBI G 83-438 Do G 83-442 Do G 83-448 Do 83-451 Do G 83-452 Do G 83-458 Do G 83-472 Hitachi Chemical Co. America Ltd. 83-473 Do 83-474 Do 83-477 Do G 83-491 Do G 83-493 Do G 83-494 Do G 83-495 Sandoz Colors & Chemicals G 83-496 CBI G 83-516 Do G 83-517 Do ® 83-521 Do G 83-544 Do G 83-545 Do 83-561 E.I. duPont de Nemours & Co., G Inc. 83-562 Do G 3.5-Dinitrosalicylaldehyde Substituted 1,3,4-thiadiazoie Primary hydrogenated alkyl amine and silicone polymer Thiacarbocyanine hydroxide, anhydrodisulfoalkyl trialkyl compound with trialkyl amine (1:1) Reaction product of a polyhalogenated anhydride, maleic anhydride, alkylene glycol and amino alcohol Disubstituted 3-phenylazo-4-amino-5-hydroxy- 2,7-naphthalenedisulfonic acid, alkali metal salt Vegetable fatty acids; benzene carboxylic acid; hydroxylmethyl alkanepolyol polymer 2.6-Bis(picrylamino)-3,5-dinitro-pyridine Disubstituted bis(phenylazo) 4-amino-5-hydroxy- 2,7-naphthalenedisulfonic acid, alkali metal salt Substituted 2-phenylazo-1-hydroxy-3- naphthalene-sulfonic acid, metal complex, alkali metal salt Substituted polyhydric alcohol 2-Propenoic acid, (2,4,6-trioxo-1,3,5-triazine-1,3,5, (2H,4H,6H)-triyl); di-2,1-ethanediyl ester 2-Propenoic acid, (2,4,6-trioxo-1,3,5-triazine-1,3,5 (2H,4H,6H)-triyl); 2,1-ethanediyl ester 2-Propenoic acid, (2,4,6-trioxo-1,3,5-triazine-1,3,5, (2H,4H,6H)-triyl); tri-2,1-ethanediyl ester Aliphatic phosphite ester Sodium carboxyalkyl thiosulfate Alkoxylated alcohol compounds Propylene glycol compounds Metal complexed, substituted aromatic salt Polyester from a carbomonocyclic anhydride and an alkanediol Aromatic polyester with substituted alkanes Polyurethane polymer with an aromatic polyester Carbomonocyclic ester Unsaturated polyester Benzene, 1 -3-bis(isocyanatomethyl) Acrylic alkyd polymer Do Do 48 FR 5304 2/4/83 48 FR 6396 2/11/83 Do Do Do 48 FR 6588 2/14/83 Do Do Do 48 FR 7299 2/18/83 Do Do Do Do 48 FR 8343 2/28/83 Do Do 48 FR 9365 3/4/83 Do 48 FR 10468 3/11/83 Do Do 48 FR 11499 3/18/83 Do 48 FR 12590 3/25/83 Do REGULATION PENDING DEVELOPMENT OF INFORMATION ... SECTION 5(e) The Administrator may issue a section 5(e) order to take effect at the end of the PMN review period. The or- der may limit or prohibit manufacture, processing, dis- tribution in commerce, use or disposal of the sub- stance. The action can be taken if information available to EPA is insufficient to permit a reasoned evaluation of the risks, and if the substance may present an unrea- sonable risk to either health or the environment. A 5(e) order may also be issued if there is insufficient infor- mation and the substance may be produced in large quantities and may result in significant or substantial human exposure, or substantial release to the envi- ronment. A 5(e) order can be a consent order or a unilatera • der. In a consent order the company that submitte a PMN negotiates the terms of the order with EPA, an the company agrees that it is bound by the order an waives its rights to file objections to the order, waiver does not affect any other rights that the compa- ny may have under TSCA. In a unilateral order, EPA takes unilateral action in re- stricting or prohibiting the manufacture, import, or use in commerce of the PMN substance and EPA sets a date for the proposed order to become an order. EPA Issues 5(e) on Shale-Derived Syncrude A 5(e) consent order has been issued for a PMN for a full range, dewaxed, dearsenited shale oil (Syncrude). The PMN subject to the order was submitted by the Un- ion Oil Company of California. The consent order was the first to be issued on the basis of substantial produc- tion volume and substantial exposure and release. The order mandates restrictions on production, volume, worker exposure controls, and waste handling, pending development of sufficient information. The order indi- rectly controls the 105 expected shale-derived refining streams that may be generated from Syncrude, which were part of Union Oil's total PMN submission. 5(e) Order for Two Chlorinated Aio Pigment PMNs EPA has determined in a recent proposed 5(e) unilateral 7 ------- order that the information made available to it in two PMNs (82-678 and 82-679) is insufficient to permit a reasoned evaluation of potential health effects. EPA further determined thai the manufacture, importa- tion, processing, and use of the two PMN substances may present an unreasonable risk of injury to human health by producing carcinogenic effects. The order will take effect on August 28, 1983, unless the company, which submitted both PMNs, files appropriate objec- tions with EPA. The company claimed its identity, the specific chemical identities and the estimated import volumes to be confidential business information. EPA used the generic term "chlorinated azo pigments" to describe the susbtances in both PMNs. The company said the PMN substances would be used as pigments in paint formulations. EPA said concern exists for both PMN substances due to the potential for formation of metabolites that may produce carcinogenic effects. If the substances undergo azo reduction, each substance wauid produce a metab- olite that is closely related to other substances already found to be carcinogenic in test animals. Importation will be banned pending development of data on the PMN substances. Issue 5(e) Orders for Two Dye Submissions EPA has issued proposed 5(e) unilateral orders for two separately submitted PMNs, because the information available indicates that each PMN substance may be carcinogenic. The PMNs, 83-401 and 83-418, are for dyes for fibers and fabrics. Their generic names are (83-401) naphthalenetrisulfonic acid, chlorotriaiinyl- amino-methoxymethylphenylazo-, and (83-418) benzendisulfotiic acid, chlorotriazinylamino- dimethylphenylszo-sulfonaphthaleneazo. Each PMN stated that the company intended to import the PMN substance. In its order for each of the two PMNs, EPA said it determined that the PMN substance may present sn unreasonable risk to human health. Unless the sub- mitter of 83-401 file objections, the proposed order will take effect on September 4, 1983. The order for 83—416 becomes effective on September 14, 1983 unless the submitter files objections. Correction On paQB 8 of the May 1983 Cftemicals-in-Proaress Bulle- tin an incorrect date w#a flivan for the 6(e) consant order for PMN 83-255. The correct date of the order is April 8, 1983. REGULATION OF HAZARDOUS SUBSTANCES . SEC- TION 6 Under section 6, EPA is author wad to control a chemi- cal as a hazardous substance if the Agency finds that the chemical will present an unreasonable risk of injury to human health or the environment. Under 6ja), EPA is required to apply one or several requirements of the law to the extant necessary to protect against the risk. EPA May Regulate MBOCA EPA published an advanced notice of proposed rule- making for 4,4'-methylene bis (2-chloroaniline). Also known as MBOCA, it is used as a hardener or curing agent in the manufacturing of certain polyurethane plastics. MBOCA has been demonstrated to be carcino- genic in animals, and EPA said that the risk from expo- sure to MBOCA may be unreasonable [May 23, t983 <48 FR 22954)3, In the notice, EPA said it wilt explore a range of regulatory options including a partial or com- plete ban. EPA has strong evidence that MBOCA is carcinogenic in several species. MBOCA has produced malignant tu- mors in the lung, liver, mammary gland and Zymbal's gland in rats at statistically significant rates, In mice and dogs MBOCA has produced malignant tumors and the notice said "the carciriogencity of MBOCA in animal studies demonstrates its potential for human car- cinogencity." MBOCA is used in the production of some coatabie polyurethane elastomers and polyurethane surface coatings. Most elastomers using MBOCA are industrial products, such as belts, gaskets, gears, rollers and solid tires. Other elastomers using MBOCA are consumer products, including heels and soles for shoes, sport boats and skate wheels. In 1979 manufacture of MBOCA ended in the United States. Current estimates of importation range from 1 to 3.5 million pounds a year. This supply is used in some 200 to 400 polyurethane production plants, where there are many opportunities for human exposure, es- pecially in the workplace. Exposure to MBOCA occurs primarily from dust during handling and from vapor from heat curing. Quarterly Progress Report to Court on PCB Rulemaking EPA in the next few months will be able to reasonably estimate safe levels of PCBa in uncontrolled PCB proc- esses. These processes produce PCBs as byproducts in products, or release PCBs to air, water, and wastes above the limits of quantitation in these media. This progress was recently described in an affidavit filed with the U.S. Court of Appeals for the District of Colum- bia Circuit. EPA, by filing the quarterly report, was com- plying with a December 17, 1982 court order that stayed a previous court mandate on uncontrolled PCB proc- esses and orderd the Agency to file quarterly reports describing the progress and status of its actions on uncontrolled PCBs. EPA plans to propose the rule for uncontrolled PCB processes in December 1983. "The Agency's hazard assessment efforts on uncon- trolled PCBs are focused on the review of data on carci- nogenicity and reproductive/developmental effects of PCBs," the EPA report said. The purpose of the exposure assessment is to estimate relative magnitudes of exposure to uncontrolled PCBs under various scenarios, the court was told, "Because of the number of chemicals potentially covered by this (PCB) rule, snd the fact that the Agency lacks detailed data on each chemical, an approach is being followed that emphasizes hypothetical exposure scenarios based on assumptions for frequency, duration, and other key parameters needed for calculating exposure," the re- port said. "As part of this effort, EPA has identified chemicais that have a relatively high potential for gen- erating PCBs as byproducts," S ------- In addition to these internal EPA activities, on April 15, 1983, the Environmental Defense Fund, the National Re- sources Defense Council, and the Chemical Manufac- turers Association jointly submitted a proposal for a fi- nal rule on the inadvertent generation of PCBs. The proposal contains two parts: proposed regulatory lan- guage and a document explaining why the proposed regulatory language comports with section 6(e) and is supportable by the available evidence. EPA views this submission as a welcome contribution to the uncontrolled rulemaking and has given it sub- stantial review and consideration. EPA anticipates that the basic framework fo the proposal will be incorpora- ted into its proposed rule for uncontrolled PCBs. Copies of the report to the court are available through TAO. REPORTING RULES HEALTH AND SAFETY RULE ... SECTION 8(d) Section 8(d) authorizes EPA to promulgate rules on specifically listed chemicals and categories of chemi- cals that would require manufacturers and processors to submit lists and copies of health and safety studies that they have conducted or were initiated by them. EPA Adds 5 Chemicals to 8(d) List An amendment to the 8(d) final rule has added five sub- stances to the list for which lists and copies of unpub- lished health and safety studies must be submitted to EPA [June 1, 1983 (48 FR 24366)]. All five added sub- stances had been designated for testing by the ITC in its 12th report (see the May 1983 Bulletin, p. 2). The sub- stances and their Chemical Abstract Numbers are: 7-Nitro-2,2-dimethyl-2,3- dihydrobenzofuran 13414-55-6 Calcium naphthenate Cobalt naphthenate Lead naphthenate Methylolurea 2-Phenoxyethanol 61789-36-4 61789-51-3 61790-14-5 1000-82-4 122-99-6 EPA Proposes to Add Substances to 8(d) List A proposal to add six substances and one mixture to the section 8(d) list was made on June 22, 1983 (48 FR 28483). If this proposal becomes final, lists and unpub- lished health and safety studies for these substances voill have to be submitted to EPA. The chemical sub- stances named in the proposed rule had been recom- mended for testing by the ITC in its 11th report (see the January 1983 Bulletin, p. 2). The one designated mix- ture named is "aromatic C, fraction from petroleum refining." EPA is adding this mixture because it has re- sponded to the ITC's recommendations on mixed ethyl- toluenes and trimethybenzenes by proposing that the aromatic C, fraction containing these substances be tested. The six substances, the designated mixture, and their Chemical Abstract Numbers are: Trimethybenzenes (mixed isomers) 25551-13-7 1,2,3-Trimethylbenzene 526-73-8 1,3,5-Trimethylbenzene 108-67-8 Methallyl 2-nitrophenyl ether 13414-54-5 7-Amino-2,2-dimethyl-2,3- dihydrobenzofuran 68298-46-4 Designated Mixture Aromatic C8 fraction from petroleum refining: The C9 fraction is primarily composed of 1,2,3,-trimethylbenzene (CAS No. 526-73-8), 1.2.4-trimethylbenzene (CAS No. 95-63-6), 1.3.5-trimethylbenzene (CAS No. 108-67-8), mixed trimethylbenzenes (CAS No. 25551-13-7), ortho- ethyltoluene (CAS No. 611-14-3), meta-ethyltoluene (CAS No. 620-14-4), para-ethyltofuene (CAS No. 622-14-4), and mixed ethyltoluenes (CAS No. 25550-14-5) in varying proportions. SUBSTANTIAL RISK ... SECTION 8(e| Under section 8fe) persons who obtain new information which reasonably supports the conclusion that a sub- stance presents substantial risk of injury to human health or the environment must notify EPA within 15 days. These notices are then reviewed by OTS and an initial evaluation is prepared containing, if appropriate, followup questions to the submitter, referrals to other agencies, and recommended OTSIEPA followup actions. The 8(e) notices represent a company's first review of a situation and a judgment in compliance with the statute to submit a notice within 15 days of obtaining the infor- mation. EPA publishes its evaluations of these notices to make this section 8(e) information widely available and understandable to a broad public. The submissions and the initial evaluations are located in the OTS Public Reading Room, first floor, East Tower, Waterside Mall, 401 M Street, SW, Washington, D.C. Persons wishing to obtain a copy of section 8(e) notices may write: EPA, Freedom of Information, Ms. Jerri Green, (A-101), Washington, D.C. 20460. There is no charge for duplicating the first 49 pages, but at page 50 of a request for duplication there is a $10.00 fee and a 200 charge for each additional page (e.g., 51 pages cost $10.20). Single copies of the 8(e) initial evaluation (not the full submission) are available from the TSCA Assistance Office. Recent Section 8(e) Notices of Substantial Risk Log No. 8EHQ- [CAS NO] 0483-0476 S Hexafluoroisobutylene 382-10-5 Summary results of two genotoxicity studies 0583-0477 S Chemical name TSCA CBI Summary of final results from a battery of short-term genotoxicity tests 0583-0478 S EPON Curing Agent* D 51365-70-9 2-Ethyl hexanoic acid compound with 2,4,6-tris [(dimethylmino)methyl] phenol A 14-day in vivo skin-application study 0583-0479 S Mixture of Polypropylene and 9003-07-0 Bis-2-hydroxyethyl-tallow amine 61791-44-4 Results of three acute inhalation toxicity studies 9 ------- 0683-0480 Mentor® 28, chemically neutralized middle petroleum distillate 64742-30-9 Summary interim results from an ongoing chronic skin- painting study CBI-Confidential business information S at the end of Log Number means a sanitized version is available. N.B.: All toxicity, oncogenicity, teratogenicity and mutagenicity studies involve animals unless otherwise stated. Additional tests (e.g., bacterial cell) are noted or are included in the term "battery." SUPPORT ACTIVITY OTS Seeks MMT Information The Office of Toxic Substances (OTS) is seeking infor- mation from the public about methylcyclopentadienyl manganese tricarbonyl (MMT) (CAS 12108-13-3) for a Chemical Hazard Information Profile (CHIP), which it is developing. A CHIP is a brief summary of readily available informa- tion concerning the health and environmental effects and potential exposure to a chemical. CHIP candidates are chosen on the basis of information indicating a po- tential for adverse health or environmental effects along with evidence of significant production or some type of exposure. When OTS searches the literature in preparing a CHIP it generally limits the search to automated data bases and reference works. But OTS encourages individuals and firms to submit unpublished or recently published re- ports, and all other hard-to-obtain studies on the chem- ical selected for the CHIP. Relevant MMT studies from the public could include data on health effects, environ- mental effects, commercial production and uses, ex- posed populations, environmental levels, or any other material that can aid in the assessment of the chemi- cal's impact on health or the environment. OTS is also interested in knowing of current MMT testing or assess- ment activities by other organizations. Information about MMT should be immediately sent to: TSCA Document Control Officer TS-793 Attn: T. O'Bryan Washington, D.C. 20460 The TAO continues to offer to notify individuals and or- ganizations by letter every time OTS starts a new CHIP. Persons who think they can aid the CHIP gathering process will have their names added to the list if they contact the TAO. All information submitted in response to the solicitations will be placed in a public file and made available for public inspection, unless the submit- ter is able to assert a claim of confidentiality in accord- ance with the provisions of section 14 of TSCA. EPA will handle all confidentiality claims in accordance with its procedures governing the confidentiality of business in- formation (40 CFR Part 2 Subpart B). The TAO is now distributing copies of the fol- lowing recently completed CHIPs: Tetrabromoethane 79-27-6 Mercaptobenzothiazole disulfide 120-78-5 Acetaldehyde 75-07-0 2-Chloronitrobenzene 88-73-3 4-Chloronitrobenzene 100-00-5 2,4-Diaminoazobenzene 495-54-5; 532-82-1 OTS encourages comment on the accuracy and thoroughness of information presented in its CHIPs. EPA Plans Asbestos Actions Under TSCA, EPA plans in 1984 to propose a rule banning certain asbestos product categories and that would establish a staged production cap on all re- maining asbestos uses. This information was given to a U.S. Senate subcom- mittee, on July 27, 1983, by Don R. Clay, Acting Assist- ant Administrator, Office of Pesticides and Toxic Sub- stances. A TSCA production cap on remaining asbestos uses may start either as a proposed rule or as an ad- vance notice of proposed rulemaking, Clay said. The members of the Toxic Substances and Environ- mental Oversight subcommittee were also told that the Office of Toxic Substances (OTS) will soon begin to is- sue risk management advisories (RMAs) on existing chemicals. These nonregulatory advisories will focus on specific problems with existing substances "and will be used to encourage meaningful precautions," Clay said. The RMAs will not be a substitute for rulemaking but sometimes will be issued in connection with rule- making activities, the Senators were told. "One of the major objectives in the TSCA program dur- ing the last two years was to get the existing chemicals program off the ground," Clay said. An Existing Chemi- cals Task Force is now in place and has reviewed 60 substances. Five of these chemicals have moved into regulatory development and about 40 are targeted for further analysis. For new chemicals, the premanufacturing notice rule (PMN) was postponed until September 10, 1983 to re- spond to a petition by The Chemical Manufacturers As- sociation and the Society of the Plastics Industry, Clay told the subcommittee. EPA will publish a clarification notice before that date. A new chemicals Advisory Circular system will summa- rize actions of specific categories of new chemicals or describe specific PMN actions. "These circulars will publicly advertise situations where EPA will likely need more data in reviewing a PMN and as such will promote early submission of such data," Clay said. Other future TSCA new chemicals action will be in bio- technology. "Biotechnology has until very recently been a laboratory-scale phenomonon; however, com- mercial uses potentially subject to TSCA regulations are 10 ------- now under development," Clay said. A copy of Clay's testimony is available through the TAO. DNA Chemicals Are Subject to TSCA TSCA provides EPA with authority to regulate the prod- ucts of biotechnology, including genetically engineered organisms, according to Don R. Clay, the Acting Assist- ant Administrator, Office of Pesticides and Toxic Substances. Clay testified before a subcommittee of the U.S. House of Representatives on June 22, 1983. He said EPA does not expect to see organisms containing genetically al- tered DNA in wide industrial use for at least several years. But he cited two examples of why it is desirable to have government review prior to commercial production of organisms containing altered DNA, as would occur through the premanufacturing notice process of TSCA. It is presently unknown, Clay said, "whether genetically engineered organisms, releasd into the environment, can be infective or toxic to humans or other organ- isms." Another unknown "is the possibility that a ge- netically modified organism could disrupt existing ecosystems," he said. Clay indicated that TSCA could cover those applications not covered by other laws such as FIFRA (pesticides) and FDA (drugs). Guidance Report Available A new booklet "TSCA Priorities and Progress" is now available through the TAO. The report updates the 1982 "Priorities for OTS Operation." It describes the Office's progress in carrying out the TSCA agenda and new di- rections for the future. The purpose of the booklet is to provide internal guidance to the OTS staff. The report is being made available to the public for the same pur- pose. OTS welcomes comments from the public on any aspect of the report. Federal Agencies Sign Task Force Chater EPA, the Consumer Product Safety Commission and the Occupational Safety and Health Administration have signed a charter formally establishing a Federal Asbes- tos Task Force. Other potentially interested agencies will be invited to join. The goals of the task force are to develop Federal perception of the asbestos health haz- ard and to recommend and coordinate further research and regulatory actions by the participating agencies. For several months, subcommittees of the task force have been meeting and sharing asbestos information, identifying areas for joint efforts and developing a con- sensus position on the asbestos risk issues. EPA Organizes Chemical Symposium EPA has organized a symposium on "Safer Chemicals Through Molecular Design." The September 11-15, 1983 conference will be held at the Hyatt Regency Crys- tal City, in Arlington, Va. The meeting is sponsored by the Society of Toxicology. The registration fee is $80, but is waived for government employees. However, preregistration is necessary for all attendees. Session titles listed in the preliminary program include: Increasing Safety by Reducing Absorption —Increasing Safety by Modifying Biotransformation Pathways and Kinetics Reducing Hazards to Aquatic Organisms —Quantitative Structure Activity Approaches to Re- ducing Toxicity —Case Studies of Reducing Toxicity Through Molec- ular Design: Drugs, Dyestuffs, Pesticides, etc. For additional nontechnical information contact: Ms. Pat Hartman (615) 574-2384 Oak Ridge National Laboratory Box X Oak Ridge, TN 37830 For technical information contact: David Klauder (202) 382-3430 EPA—TS 778 Washington, D.C. 20460 New PCB Commercial Landfill List Available The TAO has a new listing of commercial landfills ap- proved for PCB disposal. Under the section 6(e) rule dis- posal of PCBs, as defined in the rule, are prohibited ex- cept at EPA approved facilities. The new listing includes the latest information on landfill Icoations, the regional EPA contact and what type of PCB item may be dis- posed at each landfill. Strong Demand for Asbestos Guidance Book There has been a heavy demand for the recently pub- lished "Guidance for Controlling Friable Asbestos- Containing Materials in Buildings." Distribution is be- ing limited to single copies by the TSCA Regional Asbestos Coordinators, who are listed below and on the next page. The 154 page publication: • Provides a current summary of data on exposure to airborne asbestos; • Identifies issues in establishing an asbestos control program; • Reviews technical issues when assessing the poten- tial for asbestos exposure in certain indoor settings; • Summarizes data on applicability, effectiveness, and relative costs of alternative remedial actions; • Suggests a structural process for selecting a partic- ular course of action, given information on exposure levels, assessment methods and abatement techniques; • Discusses criteria for determining successful asbes- tos control. EPA REGIONAL ASBESTOS COORDINATORS Region I New England Paul Heffernan EPA JFK Federal Bldg. Boston, MA 02203 (617) 223-0585 Region II New York, New Jersey, Puerto Rico, Virgin Islands Arnold Freiberger EPA Woodbrldge Ave. Edison, NJ 08837 (201) 321-6668 Delaware, District of Columbia, Maryland, Pennsylvania, Virginia and West Virginis 11 ------- Pauline Levin EPA Curtis Bldg. Sixth & Walnut Sts. Philadelphia, PA 19106 (215) 597-9859 Region IV Alabama, Florida, Georgia, Kentucky, Mississippi, North Carolina, South Carolina and Tennessee Dwight Brown EPA 345 Courtland St., NE Atlanta, GA 30365 (404) 881-3864 Toll-free number for the region except Georgia: 800-241-1754; for Georgia: 800-282-0239 Region V Illinois, Indiana, Minnesota, Michigan, Ohio and Wisconsin Tony Restaino EPA 230 South Dearborn St. Chicago, IL 60604 (312) 353-2291 Region VI Arkansas, Louisiana, New Mexico, Oklahoma and Texas John West EPA 1201 Elm St. Dallas, TX 75270 (214) 767-2734 Region VII Iowa, Kansas, Missouri and Nebraska Wolfgang Brandner EPA 324 East 11th St. Kansas City, MO 64106 (816) 374-6538 Region VIII Colorado, Montana, North Dakota, South Dakota, Utah and Wyoming Steve Farrow EPA 1860 Lincoln St. Denver, CO 80295 (303) 837-3926 Toll-free numbers Colorado: 800-332-3321 North Dakota, South Dakota, Utah, Montana, Wyoming: 800-525-3022 Region IX Arizona, California, Hawaii, Nevada, Guam, American Samoa and Trust Territory of the Pacific, Mariana Islands Kirby Narcisse EPA 215 Fremont St. San Francisco, CA 94105 (415) 974-8123 Region X Alaska, Idaho, Oregon and Washington Jim Everts EPA 1200 Sixth Ave. Seattle, WA 98101 (206) 442-1255 Two New Reports Available The TAO is now distributing single copies of the follow- ing new EPA reports: * The April-June 1983 quarterly report on the status of existing chemicals risk evaluations. * The latest "Report to Congress on the Progress of Regulation to Protect Stratospheric Ozone." TSCA Assistance Office (TS-799) ®U8*n688 Office of Pesticides & Toxic Substances for Priv•,<, u,e U.S.E.P.A. Washington, D.C. 20460 First Class Mall Postage and Fees Paid EPA Permit No. G-35 THE TSCA CHEMICALS-IN-PROGESS BULLETIN ------- |