TSCA Chemicals-In-Progress Bulletin Vol.6, No. 1 March 1985

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What's Happening In OTS - Don R. Clay
Biotechnology. I couldn't think of a better topic to
cover in my first column. Today, new techniques for
manipulating genes offer exciting advances as re-
markable as the discovery of antibiotics or the comput-
er chip. The potential for biotechnology to improve
our ability to deal with disease and pollution and to
increase the supply of food, energy and raw materials
is clear. While these potential benefits are widely
acknowledged, legitimate concerns about safety have
also been raised, as products of biotechnology move
from contained research laboratories into the com-
mercial arena, including contact with the public and
the environment.
The scientific and policy issues in this area are ex-
tremely complex. To address these and related issues
the Federal agencies involved have proposed a coordi-
nated Federal approach, for the evaluation of pro-
ducts of biotechnology. I believe that thiscoordinated
Federal approach will serve to prevent unreasonable
risks without unduly hindering the biotechnology
industry.
The coordinated Federal approach to biotechnology,
including a policy statement by EPA, was published in
a Federal Register notice on December 31, 1984.
Development of the notice was coordinated by a bio-
technology working group of the Cabinet Council on
Natural Resources and the Environment, chaired by
the Office of Science and Technology Policy. Also
part of this notice, were proposed policies published
by the Food and Drug Administration and the U.S.
Department of Agriculture.
The notice indicates that microorganisms used as
commercial products not specifically exempt from
TSCA, e.g., pesticides, drugs, foods, are covered by
TSCA. The major impact of this conclusion is that
many new products of biotechnology will be subject
to premanufacture review under TSCA. I'd like to
emphasize that any manufacturer or importer of a new
product of biotechnology should call or come in and
talk to us in advance of filing a premanufacture notice.
This type of informal discussion has proved invalua-
ble whenever any complex issues arise in the premanu-
facture program.
Copies of the Federal Register notice can be obtained
by calling the TSCA Assistance Office, tol l-f ree 800-424-9065.
The final point I want to make is that the proposed
policy provides a comment period which closes on
April 1,1985.1 urge anyone who has any comments to
send them to us and address the envelope:
EPA Docket # OPTS 00049
Document Control Officer
TS-793 Rm. E409
Washington, D.C. 20460
We'Ve revising the Chemicals-in-Progress Bulletin to
make it more readable and more usable. If you have any
suggestions about changes or what you would like to
have in the Bulletin, write Joe Boyle, Editor, TS-799,
EPA, 401 M Street, S.W., Washington, D.C. 20460.
Don R. Clay has been the Director, Office of Toxic Sub-
stances, since August 1981. A graduate of Ohio State (M.Sc.
and B. Ch.E.) Don has over 15 years experience In government
industry.
This is the first "What's Happening in OTS" column. It is a
regular feature in which the Director discusses OTS topics of
interest. Comments on this issue's column and suggestions
of subjects you would like to see discussed are encouraged.
Write. Don R. Clay
What's Happening in OTS
EPA-OTS
TS-799
Washington, D.C. 20460
TESTING OF CHEMICAL SUBSTANCES
AND MIXTURES. SECTION 4
Section 4 of TSCA gives EPA authority to require manufac-
turers or processors of chemicals to test the toxic effects of a
designated substance. To require testing EPA must find that
the chemical may present an unreasonable risk; that there
are insufficient data available with which to perform a rea-
soned risk assessment; and that testing is necessary to
generate such data. A test rule may also be based on an EPA
finding of substantial production and exposure to humans or
the environment, in addition to findings of insufficient data
and need for testing,
Under section 4(e) an Interagency Testing Committee (ITC)
was established to recommend chemicals to EPA for priority
consideration for the promulgation of section 4 test rules.
The ITC can designate up to 50 chemicals or categories of
chemicals for testing and must make revisions to this section
4 priority list as needed. In turn, EPA must respond within
one year after the ITC adds a substance to the priority list by
starting rulemaking under section 4 or giving reasons for not
doing so.
2
-------
The ITC is made up of appointed members from eight Fed-
eral agencies, as specified in TSCA. Representatives from
six additional Federal agencies serve in a liaison capacity.
EPA Plans to Issue Chlorinated Benzenes Rule
EPA plans to issue a TSCA section 4 health effects test rule
by June 1986 for chlorinated benzenes based on an August
23,1984 Federal court ruling. EPA issued a proposed rule as
its response to the ITC on July 18, 1980 (45 FR 48524). In
1983, EPA proposed accepting a negotiated testing program
for chlorinated benzenes health effects by the Chlorinated
Producers Association. The court found that EPA cannot
respond to the ITC's designation of chemicals by accepting
negotiated testing agreements in lieu of requiring testing
through section 4(a) test rules.
In accordance with the court's August 23,1984 opinion, EPA
is proceeding with a health effects final test rule to require
oncogenicity testing of 1,2,4-trichlorobenzene and repro-
duction effects testing of monochlorobenzene, orthodi-
chlorobenzene and paradichlorobenzene.
The final rule concerning these testing requirements will be
issued in a single phase.
ITC Adds Seven Chemicals to Priority List
The 15th ITC report was sent to the Administrator on
November 6,1984. The report added seven chemicals to the
section 4(e) priority list and all were designated for response
by EPA within 12 months. The chemicals are:
Anthraquinone
2-Chloro-1,3-butadiene (Chloroprene)
Cumene
Mercaptobenzothiazole
Octamethylcyclotetrasiloxane
Pentabromoethylbenzene
Sodium N-methyl-N-oleoyltaurine
15th ITC Report
84-65-1
126-99-8
98-82-8
149-30-4
556-67-3
85-22-3
137-20-2
Chemical/Group
Recommended Studies
Anthraquinone
84-65-1
2-Chloro-1,3-butadiene
126-99-8
Cumene
98-82-8
Chemical Fate:
water solubility;
biodegradation.
Ecological Effects:
acute toxicity to fish, aquatic
invertebrates, and algae; chronic
toxicity to aquatic organisms
(testing conditional upon results
of acute tests).
Chemical Fate:
water solubility;
persistence.
Ecological Effects:
acute toxicity to sensitive life
stages of fish, aquatic inverte-
brates and algae.
Health Effects:
short-term genotoxicity; chronic
effects including oncogenicity;
teratogenicity and reproductive
toxicity.
Ecological Effects:
acute and chronic toxicity to
estuarlne and freshwater fish and
invertebrates.
Octamethylcyclotetra-
siloxane
556-67-2
Mercaptobenzothiazole Chemical Fate:
149-30-4 Dissociation constant;
persistence in water and soil;
leaching/migration.
Environmental Effects:
acute and chronic toxicity to fish,
aquatic invertebrates and plants
and terrestrial plants.
Chemical Fate:
water solutility;
octanol/water partition co-
efficient; biodegradation.
Ecological Effects:
acute toxicity to fish, aquatic
invertebrates and algae (concen-
trations of the chemical to be
measured during the course of the
studies); chronic toxicity to acquatic
organisms (testing conditional
upon results of acute tests).
Pentabromoethylbenzene Health Effects:
85-22-3 two-year chronic bioassay; tera-
togenicity study.
Ecological Effects:
acute and chronic toxicity to fish,
aquatic invertebrates and plants.
Sodium N-methyl-N-
oleoyltaurine
137-20-2
Health Effects:
short-term geno-
toxicity; sensitization; chronic tox-
icity to include oncogenicity (testing
conditional upon results of short-
term tests).
The TSCA Section 4(e) Priority List*
March 1985
Chemicals and groups of chemical* designated (or response within
12 Months Date of
Do - Ditto Recommendation
1 Anthraquinone 11/84
2 Bisphenol A 5/84
3 2-Chloro-1,3-butadiene 11/84
4 Cumene Do
5 1,2-Dibromo-4-(1,2-dibromoethyl) 5/84
cyclohexane
6 Diisopropyl biphenyl 5/84
7 2-Ethylhexanoic acid Do
8 isopropyl biphenyl 5/84
9 Mercaptobenzothiazole 11/84
10 Octamethycyclotetrasiloxane Do
11 Pentabromoethylbenzene Do
12 Sodium N-methyl-N-oleoyltaurine Do
Other Recommended Chemicals and Groups of Chemicals
Recommended but not designated for response within 12 months
1. Carbofuran intermediates 11/82
2. 3.4-Oichlorobenzotrifluoride 5/84
EPA Takes Action on Four ITC Chemical*
EPA has responded to the ITC on four chemicals the commit-
tee designated for priority consideration. The chemicals were desig-
nated in the ITC's 13th report, and ERA responded within one
year as required, on November 19,1984.
The chemicals and the EPA actions taken are:
2-(2-Butoxyethoxlyl)ester acetate 124-17-4
EPA published an Advance Notice of Proposed Rulemaking
(49 FR 45668) on the chemical, which is also known as diethylene
-------
gylcol butyl ether acetate (DGBA). The Agency is expanding
the scope of this rulemaking to include diethy lene glycol butyl
ether (DGBE) [112-34-5]. Both chemicals are members of a
larger chemical category, glycol ethers, and are likely to have
similar toxicological effects. Both chemicals have similar
acute and subacute toxicity. Both affect the renal system in
rats.
Chemical/Group
Do
Federal Register Notice
; Ditto Latest EPA Action
Ethylene bls(oxyethylene) dlacetate
111-21-7
EPA believes under the chemical's current manufacture and
use, available data are sufficient to reasonably determine or
predict the effects of health. Therefore, the Agency is not
designating the chemical for health effect testing as sug-
gested by the ITC (49 FR 45651).
1,2,3,4,7,7-Hexachloronorbornadlene (HEX-BCN) 3389-71-7
EPA believes the present limited manufacture and controlled
disposal of this chemical will not cause substantial or signifi-
cant human exposure or present an unreasonable risk of
injury to health or the environment. At present the chemical's
only use is as an intermediate in the production of endrin.
Therefore, EPA is not at this time initiating rulemaking to
require health effects testing of the chemical (49 FR 45654).
However, EPA will monitor the chemical's production by
initiating rulemaking to require both reporting of the chemi-
cal's production (section 8(a) and a 5(a)(2), significant new
use rule (SNUR).
Oleylamlne
112-90-3
EPA is proposing that manufacturers and processors of the
chemical be required to perform testing for developmental
toxicity, 90-day dermal subchronic toxicity, and mutagenicity.
The Agency's proposed rule is its response to the ITC's desig-
nation of the chemical for priority consideration of health
effects testing (49 FR 45610).
Cumulative Removals from the TSCA Section 4(e) Priority List*
February 1985
EPA Responses to ITC Recommendations
Chemical/Group
Federal Register Notice
Do = Ditto Latest EPA Action
1 Acetonitrile
2 Acrylamide/(health effects)
(environmental effects)
3 Alkyl epoxides
(see 1,2-Butylene oxide)
(see Ethylene oxide)
(see Propylene oxide)
4 Alkyl phthalates
5 Atkyltin compounds'
6 Aniline and chloro-.bromo-
and/or nltroanilines
7 Antimony metal
8 Antimony sulfide
9 Antimony trioxide
10 Aryl phosphates
11 Benzidine-based dyes
12 Benzyl butyl phthalate
13 Biphenyl
14 Bis(2-ethylhexyl)
terephthalate
15 2- (2-Butoxyethoxy)ethy I
acetate
48 FR 50942
11/4/83
46
49 FR 44142
11/2/84
47
48 FR 724
1/6/83
48
49 FR 449
1/4/84
49

50
49 FR 44142
11/2/84
51
46 FR 5456
2/5/82
52
49 FR 108
1/3/84
53

54
48 FR 716
1/6/83
55
Do
Do
56
Do
Do
57
48 FR 57452
12/29/83
58
46 FR 55004
11/5/81
59
46 FR 53775
10/30/81

48 FR 23080
5/23/83
60
48 FR 51845
11/14/83

61
49 FR 45606
11/19/84
62
•This priority is updated to reflect very recent EPA actions and
therefore differs with the list provided in the latest ITC (15th) report
submitted to EPA. Copies of the 15th ITC report, as reported in the
Federal Register, are available through the TAO.
16 1,2-Butylene oxide
(see Alkyl epoxides)
17 Butyl glycolyI butyl
phthalate
18 Calcium naphthenate
19 Chlorendic acid
20 Chlorinated benzenes
(mono-, di, tri, tetra, and
penta)
(health effects)
(environmental effects)
21 Chlorinated naphthalenes
22 Chlorinated paraffins
23 4-Chlorobenzotrifluoride
24 Chloromethane
25 2-Chlorotoluene
26 Cobalt naphthenate
27 Cresols
28 Cyclohexanone
29 O-Dianisidine-based dyes
30 Dibutyltin bis(isooctyl
meleate)2
31 Dibutyltin bis(isooctyl
mercaptoacetate)2
32 Dibutyltin bis(lauryl
mercaptide)2
33 Dibutyltin dilaurate2
34 Dichloromethane
35 1,2-Dichloropropane
36 Diethylenetriamine
37 Dimethyltin bis(isooctyl
mercaptoacetate)2
38 1,3-Dioxolane
39 Ethylene bis(oxyethylene)
diacatate
40 Ethylene oxide
(see Alkyl epoxides)
41 Ethyltoluene
42 Fluoroalkenes
43 Formamide
44 Glycidol and its derivatives
45 Halogenated alkyl epoxides
(see Hexafluoropropylene oxide)
Hexachloro-1,3-butadiene
Hexachlorocyclopentadiene
Hexachloroethane
1,2,3,4,7,7-Hexachloronor-
bornadiene
Hexafluoropropylene oxide
(see Halogenated alkyl epoxides)
Hydroquinone
Isophorone
Lead naphthenate
Mesityl oxide
4,4'-Methylenedianiline
Methyl ethyl ketone
Methyl isobutyl ketone
Methylolurea
Monobutyltln tris(isoocytyl
mercaptoacetate)2
Monomethyltin tris(isooctyl
mercaptoacetate)2
Nitrobenzene
Oleylamine
63 2-Phenoxyethanol
49 FR 18779
5/2/84
46 FR 54487
11/2/81
49 FR 30114
7/26/84
47 FR 44878
10/12/82
49 FR 18779
5/2/84
49 FR 1760
1/13/84
49 FR 32113
8/24/84
49 FR 44142
11/2/84
49 FR 18779
5/2/84
45 FR 48524
7/18/80
49 FR 30114
7/26/84
49 FR 21411
5/21/84
48 FR 31812
7/11/83
49 FR 44142
11/2/84
46 FR 55004
11/5/81
48 FR 51361
11/8/83
Do
Do
Do
Do
Do
Do
49 FR 25009
6/19/84
49 FR 899
1/9/84
47 FR 18386
4/29/82
48 FR 51361
11/8/83
49 FR 32113
8/10/84
49 FR 45651
11/19/84
49 FR 200
1/3/84
49 FR 1696
1/13/84
49 FR 23112
6/4/84
48 FR 57366
12/29/83
48 FR 57562
12/30/83
48 FR 57695
Do
47 FR 58029
12/29/82
47 FR 58023
Do
47 FR 18175
4/28/82
49 FR 45654
11/19/84
48 FR 57686
12/30/83
)
49 FR 438
1/4/84
49 FR 2012
1/17/84
49 FR 21411
5/21/84
49 FR 1536
1/12/84
49 FR 31806
7/11/83
47 FR 58025
12/29/82
Do
Do
49 FR 21371
5/21/84
48 FR 51361
11/8/83
Do
Do
49 FR 25013
6/19/84
49 FR 45610
11/19/84
49 FR 30114
7/28/84
' Removed by the ITC for reconsideration. Seven Individual alkyltin
compound group members were subsequently designated In the 11th
ITC report for priority consideration.
1 One of seven alkyltin compounds. See Note 1 above.
-------
Chemical/Group
Federal Register Notice
Do = Ditto Latest EPA Action
Chemical/Group
Federal Register Notice
Do = Ditto Latest EPA Action
64
Phenyienediamines
65
Polychlorinated terphenyls
66
Propylene oxide

(see Alkvl epoxides)
67
Pyridine
68
Quinone
69
4-(1,1,3,3-Tetramethylbutyl)

phenol
70
o-Tolidine-based dyes
47 FR 973 1/8/82
46 FR 54482 11/2/81
48 FR 430 1/4/84
47 FR 58031 12/29/82
49 FR 456 1/4/84
49 FR 29449 7/20/84
46 FR 55004 11/5/81
71
Toluene
72
1,2,4-Trimethylbenzene
73
Trimethylbenzenes
74
1,1,1-Trichloroethane
75
Tris(2-chloroethyl)

phosphite
76
Tris(2-ethylhexyl)

trimellitate
77
Xylenes
47 Fr 56391 12/16/82
49 FR 1696 1/13/84
Do Do
46 FR 30300 6/5/81
47 FR 49466 11/1/82
49 FR 23116 6/4/84
47 FR 56392 12/16/82
MANUFACTURING AND PROCESSING NOTICES. . .SECTION 5
Section 5 of TSCA gives EPA authority to quickly review and control, if necessary, new chemicals to prevent large scale
distribution before a new substance's effects on health or the environment are fully determined. Below and on the next few pages
are subsections of section 5 highlighted because of recent EPA actions.
Proposal to Amend Stayed Provisions of the PMN Rule
EPA is proposing to amend the stayed provisions of the 1983 final TSCA section 5 PMN rule. The stayed portions
concerned chemical substances used for research and development (R&D), the definition of "possession or
control," and data requirements on related chemicals.
Section 5(h)(3) exempts small quantities of new chemical substances, manufactured solely for R&D, from PMN
requirements. In a proposal published on December 27,1984, (49 FR 50201), EPA defined procedures governing this
exemption. Companies would be required to conduct R&D activities involving new chemical substances under the
supervision of a technically qualified expert; notify employees of health risks, and notify customers that the
substance was to be used solely for R&D. Substances produced for R&D could not subsequently be sold for
non-R&D purposes—for example, when the testing was completed—unless they are incorporated into an article.
The proposed rule also seeks to eliminate ambiguities by amending the definition of "possession or control" of data
on PMN chemicals, data requirements on related chemicals, and exemption from PMN requirements for chemicals
produced solely for export.
Significant New Use
Under section 5(a)(2) EPA may determine by rule that certain
uses of chemical substances are significant new uses. These
rules are referred to as Significant New Use Rules (SNURs). In
making the determination, the Agency considers the expo-
sure associated with the use, the toxicity associated with the
chemical and whether the use is ongoing at the time the rule is
proposed. Persons covered by a SNUR must notify EPA at
least 90 days before manufacturing or processing a chemical
substance for the defined significant new use or uses.
A SNUR may be issued for any TSCA chemical substance.
SNURs may be written for individual chemicals, for chemical
categories, and for new or existing chemicals. New chemical
SNURs may be written in conjunction with a 5(e) order, or
they may be written as followup rules.
Under a 5(e) order, a company submitting a Premanufacture
Notice (PMN) may only engage in certain activities. Once
manufacture commences, the chemical is placed on the
Inventory. If no SNUR is issued, the chemical may be used by
other manufacturers without any restrictions. To establish
equity of treatment, EPA issues 5(e) SNURs that require
manufacturers to notify EPA before engaging in any activities
other than those permitted in the 5(e) order.
The Agency also writes followup SNURs for certain new
chemicals which were not subject to 5(e) orders. These
SNURs address concerns which did not trigger a 5(e) order
either because the concerns arose after the completion of the
PMN review or because the uses described in the PMN did not
involve enough exposure to warrant action. Followup SNURs
allow the Agency to permit safe uses of potentially hazardous
new substances while ensuring that it has the opportunity to
review uses which may lead to significant changes in human
or environmental exposure.
Finally, EPA develops SNURs to support the Existing Chemi-
cal Program's risk assessment and risk management activi-
ties. SNURs for existing chemicals are used to monitor signif-
icant new uses of substances on the TSCA Chemical Sub-
stances Inventory. As with SNURs for new chemicals, existing
chemical SNURs ensure that the Agency will receive informa-
tion on significant new uses of potentially hazardous sub-
stances before such uses occur. These SNURs also enable
EPA to take immediate followup control action (under TSCA
sections 5(e) or 5(f)) to limit potential exposure resulting from
significant new uses of existing chemical substances, pro-
vided that such followup action is necessary.
Section 5(e) Action Pending Development of Information
The A dministratormay issue a section 5(e) order to take effect
at the end of the PMN review period. The order may limit or
prohibit manufacture (import), processing, distribution in
commerce, use, or disposal of the PMN substance. The action
can be taken If information available to EPA is insufficient to
permit a reasoned evaluation of the risks, and if the substance
may present an unreasonable risk to either health or the
environment. A 5(e) order may also be issued if there is insuf-
ficient information and the substance may be produced in
large quantities and may result in significant or substantial
human exposure, or substantial release to the environment.
A 5(e) order can be a consent order or a unilateral order. In a
consent order, EPA negotiates the terms of the order with the
company that submitted the PMN. The company agrees to be
bound by the order and waives its rights to file objections to
the order.This waiver does not affect any other rights that the
company may have under TSCA. The company at a later date
can request a modification of the consent order. In a unilat-
eral order E PA takes action to restrict or prohibit the manufac-
ture or use in commerce of the PMN substance.
5
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PMN

Chemical Identification
G = Generic Name*
5(e)
Consent or
Unilateral Order
5(a)(2)
Proposed or
Final SNUR
80-289
and
80-290

Isopropylamine distillation
residues (79771-08-7)
Ethylamine distillation residues
(79881 -09-8)

Final Rule
49 FR 46373
11/26/84
50503A
81-69
and
81-125
G
G
Benzophenonetetracarboxylic acid dimethyl ester, reaction product
with methylenedianiline and substituted pyridine
Benzophenonetetracarboxylic acid dimethyl ester, reaction product
with methylenedianiline and alkytenediamine: and
benzophenonetetracarboxylic acid dimethyl ester, reaction with
methylene dianiline, alkylbenzenediamine and substituted pyridine

Proposed Rule
49 FR 5029
12/27/84
50512
82-438

Benzoic acid 3,3'-methylene bis
(6-amino-di-2-propenyl ester)
(61386-62-5)

Proposed Rule
50 FR 127
1/2/85
50518
82-684
G
Derivative of tetrachloroethylene
1/17/83
Final Rule
49 FR 42928
10/25/84
50507A
83-23, 24,
49,75,
272
G
Substituted methyl pyridine
and
Substituted 2-phenoxypyridine
3/9/83
Final Rule
49 FR 50396
12/28/84
50505A
83-105
G
1,2-Benzenediamine, 4-ethoxy, sulfate

Final Rule
49 FR 43058
10/26/84
50504A
83-255
G
Dicarboxylic acid monoester
4/8/83
Final Rule
49 FR 43061
10/26/64
50508A
83-394
G
Substituted polyglycidy! benzeneamlne
8/16/83
Final Rule
49 FR 43649
10/31/84
5051 OA
83-817
and
83-818
G
[(Dinitrophenyl)azoH2,4-dlamino-5-Methoxybenzene] derivatives

Proposed Rule
49 FR 42960
10/25/84
50519
83-822
G
Disubstituted diamlno anisole
2/29/84
Proposed Rule
49 FR 48874
12/7/84
50521
84-27
G
Alkyl glycolether acrylic acid derivative
2/29/84
Proposed Rule
49 FR 49868
12/24/84
50522
•A generic name in this list may be different from the generic name listed when the PMN was first published in the Federal Register During SNUR
negotiations a more specific generic may have been assigned.
6
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REPORTING AND RETENTION OF INFORMATION .. SECTION 8
Preliminary Agtestment Information
The TSCA section 8(a) Preliminary Assessment Information rule
requires chemical manufacturers (including certain producers
and importers) to submit data on the quantities of chemicals
manufactured, the amounts directed to certain classes of uses,
and the potential exposures and environmental releases asso-
ciated with the manufacturer's own and his immediate custom-
ers' processing of the chemicals.
Require Report*, Studies on New ITC Chemical*
The seven chemicals listed in the 15th ITC report were added to
the TSCA section 8(a) Preliminary Assessment Information
rule and section 8(d) Health and Safety Data Reporting rule.
Manufacturers of these listed chemicals had to submit a com-
pleted Preliminary Assessment Information report by February
28, 1985. Section 8(a) reporting forms are always available
through the TAO.
The chemicals are:
Anthraquinone 84-65-1
Pentabromoethyibenzene 85-22-3
Cumene 98-82-8
2-Chloro-1,3-butadiene (Chloroprene) 126-99-8
Sodium N-methyl-N-oleoyltaurine 137-20-2
Mercaptobenzothiazole 149-30-4
Octamethylcyclotetrasiloxane 556-67-2
Health and Safety Data Reporting
Section 8(d) of TSCA authorizes EPA to promulgate rules on
specific chemicals and categories of chemicals that require
manufacturers and processors to submit lists and copies of
health and safety studies that they initiate or conduct, know
about or can reasonably discover.
In another action, EPA recently proposed a rule to add 3,4-
dichlorobenzotrlfluoride (CAS No. 328-84-7) to the section 8(a)
Preliminary Assessment Information rule and the 8(d) Health and
Safety Data Reporting rule. The chemical, included in the ITC's
14th report, was recommended but not designated by the Com-
mittee for EPA resonse within 12 months. However, EPA needs
the data to evaluate risks associated with this chemical.
All chemicals and mixtures designated by the ITC for
testing consideration by EPA within 12 months are subject
to automatic reporting by their manufacturers. On Novem-
ber 19,1984, the Agency proposed to extend the auto-
matic reporting provision to include those chemicals
recommended by the ITC but not designated for action by
the Agency within 12 months.
Significant Adverse Reaction Records.. .Section 8(c)
Section S(c) of TSCA requires manufacturers and certain proc-
essors of chemical substances and mixtures to keep records of
significant adverse reactions to health or the environment
alleged to have been caused by a chemical substance or mix-
ture. Allegations of adverse reactions to the health ol employees
must be kept for 30 years and all other allegations for five years.
EPA may inspect these records and require submissions of
copies of these records.
EPA Seeks to Clarify Section 8(c) Provisions
EPA is proposing to amend parts of the section 8(c) regulations,
December 24, 1984 (49 FR 49867).
Section 8(e).. .Substantial Risk
Under section 8(e) persons who obtain new information which
reasonably supports the conclusion that a substance presents
substantial risk of injury to human health or the environment
must notify EPA within 15days. These notices are then reviewed
by the Office of Toxic Substances (OTS) and an Initial evaluation
is prepared containing, if appropriate, followup questions to the
submitter, referrals to other agencies, and recommended OTS/
EPA followup act/ons. The 8(e) notices represent a company's
first review of a situation and a judgment in compliance with the
statute to submit a notice within 15 days of obtaining the
Information.
e One amendment adds an exemption for "coincidental
manufacturers." This provision states that coincidental
manufacture of chemical substances is not an act that by
itself, makes a person subject to the rule. This amendment
parallels exemptions in the TSCA Inventory regulations as
well as the final PMN Rule.
• Another amendment clarifies what processors are subject
to the rule. The amendment places the emphasis on a
company's end product. That Is, a company Is a processor
subject to the rule if its products are of the type described
in Standard Industrial Classification (SIC) codes 28-
Chemicals and Allied Products, or 2911 Petroleum re-
fining.
• The preamble of the rule also clarifies the fact that all
manufacturers of chemical substances are subject to the
rule. However, only those manufacturers of mixtures
whose products fall in the SIC codes mentioned above are
subject This is because a mixture manufacturer (who is
not also a substance manufacturer) is part of the proces-
sor universe.
• Finally, the preamble clarifies what operations or plant
sites within a company are likely to be affected by the rule.
The product stewardship concept applies here.
7
Reported 8(e) Finding In Error
In an initial section 8(e) submission (8EHQ-0284-0505), the
Standard Oil Company (Indiana) reported the following prelimi-
nary findings from a 3-week rat dermal application toxicity study
of a dewaxed solvent-refined heavy paraffinic distillate:
"The test animals [(rats)] were divided into two groups, each
consisting of 10 males and 10 females. One group was
treated with 2.0 ml/kg of base oil by application on the skin
for 15 consecutive weekdays. The rats In the sham control
group did not receive the test material but were otherwise
handled exactly like the treated rats. There were no treat-
ment related lesions observed In the treated or sham control
group upon gross observation. However, microscopic
examination
-------
In summary, the submitted followup information shows that the
adverse testicular effects reported in the company's initial 8(e)
notice were actually artifacts resulting from improper tissue sec-
tioning of testes from the treated animals. In addition, data from
the repeated 3-week dermal application study show no adverse
morphologic testicular effects in rats exposed to the dewaxed
solvent-refined heavy paraffinic distillate.
EPA publishes its evaluations of section 8(e) notices to make this
information widely available and understandable to a broad pub-
lic. The submissions and the initial evaluations are located in the
OTS Public Reading Room, first floor, East Tower, Waterside
Mall, 401 M Street, SW, Washington, D.C.
Persons wishing to obtain a copy of section 8(e) notices may
write: EPA, Freedom of Information, Ms. Jerri Green, (A-101),
Washington, D.C. 20460. There is no charge for duplicating the
first 49 pages, butat page 50 of a request for duplication there is a
$10.00 fee and a 20C charge for each additional page (e.g., 51
pages cost $10.20).
Single copies of the 8(e) initial evaluation (not the full submission)
are available from the TAO.
Recant Section 8(a) Notice* of Substantial Risk
Log. No. [CAS NO]
0984-0531 S
Fatty acid imidazoline 68442-97-7
Summary results from several acute toxicity studies
1084-0532
5,7,11-Dodecatriyn-1-1-oL.
Summary results from several in vitro and in vivo toxicity studies
1084-0533 S
2-Chloro-5-trichloromethyl pyridine 69045-78-9
Summary results from a battery of In vitro genotoxicity studies
1084-0534
2-Methoxyethyl palmitate (2-MEP) 111 -07-9
Summary results from a subacute oral toxicity study
1084-0535
1,1,1 -Trichloroethane (TCE) and
Perfluoroalkyl resin mixtures
Results of several acute Inhalation toxicity studies
1184-0536
Cumene (1 -methylethyl) benzene 98-82-8
Summary results of two in vitro genotoxicity tests
1184-0537
Light Pyrolysis Fuel Oil
Summary results from several In vitro genotoxicity studies
1284-0538
Solvent-Refined Coal (SRC) Solid
Summary interim results from an ongoing 2-year Inhalation study
1284-0539
Pyrogallol (1,2,3-benzenetrlol) 87-66-1
Summary results from a battery of in vitro genotoxicity assays
S at the end of a Log Number means a sanitized version is available.
N.B. All toxicity, oncogenicity, teratogenicity and mutagenicity studies
Involve animals unless otherwise stated, Additional tests (e.g., bacterial
cell) are noted or are included In the term "battery."
Latest FYI Submissions
FYI (For Your Information) records are submissions received
by the Office of Toxic Substances on chemical toxicity and/or
exposure. FYls are submitted by chemical manufacturers, proc-
essors and distributors, trade associations, labor organiza-
tions, Federal, State and local agencies, foreign governments,
academia, public interest and environmental groups, as well as
the general public. These submissions are provided to EPA on a
voluntary basis and not in response to a mandatory reporting
provision of TSCA. Microfiche copies of these submissions are
located in the OTS Public Reading Room, first floor, East
Tower, Waterside Mall, 401M Street, S.W., Washington, D.C. To
obtain a copy of an FYI follow the procedure outlined in this
section 6(e) section directly above.
Recent FYI Notices
Document Control No. FYI—
Chem. Name CAS No.
AX-1284-0371
Naphtha (petroleum), Light Catalytic 64741-55-5
Cracked
Naphtha (petroleum), Light Catalytic 64741-63-5
Reformed
Naphtha (petroleum), Full Range 68919-37-9
Reformed
Final results from a battery of acute toxicity
tests
AX-1284-0372
Petroleum Refinery Chemicals
Methodology for epidemiological studies
AX-0185-0373
p-tert-Octylphenol
Final results from a battery of 140-66-9
aquatic toxicity studies
AX-0185-0374
Petroleum Refinery Effluents
Preliminary results from aquatic toxicity
studies
OTS-0185-0375
Trichloroethylene 79-01-6
Volatile Organic Compounds
Report of groundwater contamination
OTS-0185-0376
n-Butyl Perchlorocrotonate 21824-93-1
Final results from a battery of genotoxicity
tests
OTS-0185-0377
Polychlorinated Biphenyls
Report of product contamination
8
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Reminder on Reporting Groundwater Contamination and Chemical Release Under Section 8(e)
We have received a number of groundwater contamina-
tion reports and chemical release reports from the chemi-
cal industry under section 8(e).
Increased concern over such risks leads us to remind
readers that groundwater contamination is included in the
term "environmental media" and that both groundwater
contamination and emergency incidents of environmental
contamination are reportable under TSCA's section 8(e).
This reporting policy is stated in the Agency's Statement of
Interpretation and Enforcement Policy concerning notifi-
cation of substantial risk, published in the Federal Regis-
ter on March 16,1978 (43 FR 11110).
The section 8(e) policy statement directs chemical manu-
facturers, importers, processors, and distributors to report
in writing to EPA within 15 working days all available
information regarding "widespread and previously unsus-
pected distribution of chemical substances in environ-
mental media." And, as noted above, groundwater con-
tamination is included in environmental media.
The section 8(e) policy statement also directs chemical,
manufacturers, importers, processors and distributors to
report to EPA immediately (within 24 hours by phone and
within 15 calendar days in writing) all available informa-
tion concerning an emergency incident of environmental
contamination. This is defined as any environmental con-
tamination by a chemical substance or mixture to which
any serious adverse health or environmental effects has
been ascribed and which because of the pattern, extent,
and amount of contamination (1) seriously threatens
humans with cancer, birth defects, mutation, death, or
serious or prolonged incapacitation, or (2) seriously
threatens non-human organisms with large-scale or eco-
logically significant population destruction." As in the
case of reports of groundwater contamination, EPA has
received a number of section 8(e) notices dealing with
chemical releases.
Although the overall scope of TSCA section 8(e) is quite
broad, the following limitations should be noted:
(1) It pertains only to those chemical substances
defined as such in TSCA;
(2) It pertains only to those persons who are defined
in TSCA as being chemical manufacturers, im-
porters, processors, or distributors;
(3) It pertains only to mandatory reporting of informa-
tion concerning a chemical substance or mixture
that a subject person manufactures, imports,
processes, or distributes; and
(4) It pertains only to that information about which the
EPA Administrator has not been adequately in-
formed. Part VII of the TSCA section 8(e) policy
statement describes the types of information that
need not be reported to EPA under section 8(e).
For example, Information need not be submitted
under section 8(e) if the information has been
reported already to EPA pursuant to a mandatory
reporting provision of another authority adminis-
tered by EPA (e.g., CERCLA, ("Superfund"),
FIFRA, CWA, CAA, etc.).
The above listed limitations notwithstanding, section 8(e)
of TSCA is an important information-gathering tool that
aids the Agency in its efforts to (1) identify previously
unknown sites of groundwater contamination, and (2) pre-
vent toxic chemicals from causing harm to human health
or the environment.
EPA Files $6.8 Million Complaint Against Firm
EPA filed a civil administrative complaint seeking a $6.8 mil-
lion penalty against a firm for alleged illegal disposal,
processing, distribution and storage of polychlorinated
biphenyls (PCBs) and for alleged sale of six million gallons of
heating oil contaminated with the substance.
The penalty is the largest ever sought under TSCA and caps
an 18-mohth Federal investigation. The complaint charged
that Chemical Waste Management Inc., of Oak Brook, Illinois
put PBCs in waste lagoons at its Vickery, Ohio disposal facilities
continually from 1980 to 1983 in an effort to dilute the
PCBs and avoid TSCA regulations requiring incineration of
PCB fluids. Some of the lagoons had PCB concentrations as
high as 1,500 parts per million, according to the EPA
complaint.
After dilution some of the waste was sold as reclaimed oil,
EPA charged. In addition to the illegal disposal, processing
and distribution of PCBs, the corporation was also accused of
violating TSCA recordkeeping requirements.
According to an EPA Region 5 (Chicago) official, Chemical
Waste Management, Inc. acted quickly to end the violations
after a March 1983 press release disclosed the alleged
conditions.
CITIZENS' PETITION.. .SECTION 21
Any person may petition EPA to begin a proceeding for the
issuance, amendment or repeal of a rule under section 4 or 8,
or an order under section 5(e) or 6(b)(2), of TSCA. EPA may
either grant or deny the petition. It it is granted, EPA must
promptly commence an appropriate proceeding under sec-
tion 4, 5, 6, or 8 of the Act. Denials must be published in the
Federal Register with the reasons for the denial. If EPA denies
the petition or fails to act within 90 days, the petitioner may
begin a civil action in a U.S. District Court.
EPA Responds to Petition on Dioxins and Dlbenzofurans
In its response to a petition filed by the Environmental
Defense Fund and the National Wildlife Federation, EPA
reported that it was deeply involved in addressing the risks
posed by dibenzo-pdioxins (dioxins) and dlbenzofurans.
EPA said it was well into the implementation phase of
the National Dioxin Strategy. As part of that strategy, a
National Dioxin Study, now under way, will provide valuable
information on the extent of environmental contamination.
Secondly, EPA will take action on dioxins under TSCA and
other laws it administers. For example, under the Federal
Fungicide, Insecticide, and Rodenticide Act, EPA has limited
dioxin exposure from contaminated pesticides. Under the
Resource, Conservation and Recovery Act, EPA has listed
wastes containing dioxins and dlbenzofurans as hazardous
-------
wastes. Under TSCA's information gathering authority, EPA
will begin an administrative proceeding to determine if the
statutory findings can be made for a section 4 and 8 rulemak-
ing. Finally, further EPA led research will evaluate the forma-
tion, toxicity, environmental fate, destruction and
measurement of dioxins and furans.
EPA's announcement was made on January 22,1985, by Act-
ing Administrator Lee Thomas, in response to a petition filed
under section 21 of TSCA. The petition requested that EPA
take a wide variety of actions to address perceived threats to
human health and the environment from dioxins and
dibenzofurans and suggested using TSCA to do so.
Data Sought on Non-Asbesto» Brake Products
EPA is seeking recent information on non-asbestos brake
products for vehicles. This information sought is on non-
asbestos brakes, both in actual production and under devel-
opment. The search grows out of EPA's granting of a TSCA
section 21 citizens' petition filed by the Natural Resources
Defense Council that asked for a prohibition of the use of
asbestos in car and truck brakes.
Asbestos Is a human carcinogen that causes lung cancer and
mesothelioma as well as other lung disorders. EPA reported in
a December 19, 1984 notice granting the petition (49 FR
49311) that an estimated 2,750 people are potentially exposed
to asbestos during the manufacture of brake friction material.
The Agency also said about 500,000 people may be exposed
to asbestos during servicing and repair of vehicle brakes. In
addition, all persons are exposed to asbestos fibers in the air
through the wear of asbestos brakes in vehicles being driven.
In order to issue any rules under section 6 of TSCA, which
considers a criterion of "unreasonable risk," EPA must first
examine the effects of a chemical on health and the magni-
tude of exposure as well as the benefits of using the chemical
and the availability of substitutes.
Persons having information on the availability of substitutes
for asbestos in brakes and on substitute products that are
currently being developed may call the TAO for information
on how to send the information to EPA. Persons may also
comment on other issues relating to the petition.
The chemicals have been selected for preliminary assessment
review. Information should be sent to:
TSCA Document Control Office (TS-793)
ATTN: T.O'Bryan
Washington, D.C. 20460
Information about dimethyl hydrogen phosphite received
after March 1,1985 and on other named trifalkyl/alkoxy) phos-
phates after March 18,1985 may not be received in time to be
included in the reviews but will be considered during OTS
discussions to decide an appropriate course of action on the
chemical substances and appended as necessary. All informa-
tion submitted in response to this solicitation will be placed in
a public file and made available for public inspection, unless a
submitter is able to assert a claim of confidentiality in accord-
ance with the provisions of section 14 of TSCA. EPA will
handle all confidentiality claims in accordance with its proce-
dures governing the confidentiality of business information.
Persons who have unpublished data about the chemicals, but
who also want answers to questions prior to responding
should contact John Leitzke of the OTS Chemical Screening
Branch, (202) 382-3507, as soon as possible.
The OTS review of the chemicals when completed will be in
reports called Chemical Hazard Information Profiles (CHIPs).
A CHIP is a brief summary of readily available information
concerning the health and environmental effects and poten-
tial exposure to.a chemical. CHIP candidates are chosen on
the basis of information indicating a potential for adverse
health or environmental effects along with the evidence of
significant production or some type of exposure.
When OTS searches the literature in preparing a CHIP it gen-
erally limits the search to automated data bases and reference
works. But OTS encourages individuals and firms to submit
unpublished or recently published reports and all other hard-
to-obtain studies on the chemical selected for a CHIP. Rele-
vant studies from the public could include data on health
effects, environmental effects, commercial production and
uses, exposed populations, environmental levels, or any other
material that can aid in the assessment of the chemical's
impact on health or the environment. OTS Is also interested in
knowing of current testing of a CHIPcandidateor assessment
activities by other organizations.
The TAO will notify individuals and organizations by letter
every time OTS starts a new CHIP. Persons who think they
can aid the CHIP information-gathering process will have
their names added to our contact list if they tell the TAO.
OT8 Sacks CHIP Data
OTS is asking the public for unpublished information about
the following chemicals:
Dimethyl hydrogen phosphite 868-85-9
Tri(alkyl/alkoxy) Phosphates
[Tri (2-ethylhexyl) Phosphate 78-42-2]
[Tributoxyethyl Phosphate 78-51-3]
[Tributyl Phosphate 126-73-8]
[Trldecyl Phosphate 4200-55-9]
(CAS Nos. of the remaining minor chemicals in
this class are as follows: 126-71-6; 512-56-1; 919-62-
0; 1623-19-4; 3033-37-2; 56827-95-3; 64131-07-3;
64131-08-4; 64131-09-5; 64131-10-8; 84131-18-
6:4889-45-6; 6163-73-1; 7332-46-9; 10427-00-6;
57344-01-1; 57344-02-2; 64502-13-2; 73070-47-0;
74049-24-4)
The TAO Is distributing copies of the following recently
completed CHIPs:
Butyiated hydroxytoluene 128-37-0
Diethythexyl adipate (OEHA) 103-23-1
Naptha (petroleum) solvents 64741-66-8
64742-88-7
Tetrachloro-1-propene (1,1,2,3) 10435-39-2
OTS encourages comments on the accuracy and tho-
roughness of information presented tn the CHIPs.
10
Ravlaad TSCA Security Manual Ready
A revised security manual is being distributed to EPA
employees who handle TSCA confidential business informa-
tion. The new edition contains the changes to the TSCA secur-
ity procedures put Into effect during the last three years. At
this time, a second volume, the 1961 security manual for
TSCA contractors and subcontractors remains in effect. Both
documents are on file in the TSCA Assistance Office.
-------
MANUFACTURING AND PROCESSING NOTICES.. SECTION 5
Section 5 of TSCA gives EPA authority to quickly review and control, if necessary, new chemicals to prevent large scale
distribution before a new substance's effects on health or the environment are fully determined.
Commencement Of Manufacture Notice*
Under section 5(a)(1) a person who intends to introduce into commerce a chemical substance not on the TSCA inventory must
notify EPA at least 90 days before beginning manufacture or import. Listed below on the next few pages are the latest commence-
ment of manufacture notices EPA has received.
NEW CHEMICAL SUBSTANCES FOR WHICH EPA HAS RECEIVED COMMENCEMENT
OF MANUFACTURE NOTICES
(tine* publication of the November 1984 Chamlcala-ln-Prograta Bullatln)

FR
PMN no
Submitter
Chemical Identification
Citation

CBI = Confidential Business Information

G = Generic Name*
Do = Ditto
81-203
CBI
G
Substituted alkyl cyanoacrylate ester
46 FR 29524

6-2-81
81-638
Do
G
Polyether reaction product with toluene diisocyanate-methacrylate
46 FR 62687

terminated
12-28-81
82-198
Do
G
Modified polyurethane of a substituted alkane diol and a diisocyanate 47 FR 11957

3-19-82
82-441
U.C.T. Inc.
G
Alkylphenol, formaldehyde, alkanolamine, alkylene oxides reaction
47 FR 27610

product
6-25-82
82-471
Ashland Chemical Co.
G
Terephthalic acid modified unsaturated polyester resin
47 FR 30103

7-12-82
83-252
CBI
G
Alkyl amino-amide salt
47 FR 54537

12-3-82
83-264
Do

Condensation polymer of ethyl acrylate and ethanolamine
47 FR 55422

12-9-82
83-286
Witco Chemical Corp.
G
1,1-Dimethyl ethyl peroxyester
47 FR 57332

12-23-82
83-313
CBI
G
Polymer of alkane polyols, alkane dioic acid and aromatic acid
47 FR 57336

12-23-82
83-339
Do

5-[4-Chloro-6-[3-[2-(hydroxysulfonyloxy)ethylsulfonyl]anllino]-1,3,5-
48 FR 862

trlazin-2-ylamino]-3-(1,5-disulfo-2-naphthylazo)-4-hydroxy-
1-7-83

2,7-naphthalenedisulfonic acid, pentasodium salt.

83-341
Do

7-[4-[4-Chloro-6[3-[2-(hydroxysulfonyloxy) ethyl sulfonyl]anilino]-1,3,5
Do

triazin-2-ylamino]-2-ureldiphenylazo]-1,3,6-naphthalene-trisulfonlc acid,

tetrasodium salt

83-343
Do

4-Amino-6-[5-[4-chloro-6-[3-[2-[hydroxysulfonyloxy)ethyl sulfonyl]
Do

anllino]-1,3,5-triazin-2-ylamino]-2-sulfophenylazo]-5-hydroxy-3-(4-

sulfonphenylazo)-2,7-naphthalenedlsulfonic acid, pentasodium salt

83-436
FMC Corp.
G
Chloroaromatic compound
48 FR 6396

2-11-83
83-446
Emery Industries, Inc.

I so hexadecyl isostearate
48 FR 6588

2-14-83
83-492
Reilly Tar & Chemical Corp.

4-(4-Methyl-1-piperidlnyl)pyridlne
48 FR 8343

2-28-83
83-630
CBI
G
Reaction product of an aromatic diglycidyl ehter, an amine and a
48 FR 17385

cyclic ester
4-22-83
83-686
Do
G
Modified ethylenetetrafluoroethylene copolymer
48 FR 21370

5-12-83
83-694
Do
G
Polyester of phthalic anhydride and polyhydric saturated alcohols
Do
83-728
Hercules, Inc.
G
Organic siiane-sulfonyl azide
48 FR 22792

5-20-83
83-746
CBI
G
Esterified vinyl, alkenyl polymer
48 FR 23903

5-27-83
83-843
American Hoechst Corp.

2,2'-(Ethylenedioxy-bl8-(2-phenylazo)-bl8 (n-2,3-dihydro-2-oxo-1H-
48 FR 30434

benzimidazol-5-y1) 3-oxo-butanamide)
7-1-83
83-998
Marubeni America Corp.
G
6-Dlbutylamino-2-(substltuted) splro (xanthene-9,3-phthalide)
48 FR 35713

8-5-83
83-1005
CBI
G
Polycarboxylic acid, alkanolamine salt
48 FR 36647
83-1015

8-12-83
Essex Specialty Products
G
Isocyanato functional polycarbamoyl(poyalkylene oxide) oligomer
Do
83-1016
Do
G
Do
Do
83-1017
Do
G
Do
Do
83-1026
CBI
G
Disubstitutiedsulfamoyicarbomonocycle azo substituted naphthalene 48 FR 37689

sulfonic acid, sodium salt
8-19-83
11
-------
83-1045
Do
G
1,3-Naphthalenedisulfonic acid, 4-amino-5-hydroxy-6-arylazo
Do
83-1051
GTE Products Corp.

Thiomolybdic acid, diammonium salt
48 FR 38889

8-26-83
83-1062
CBl
G
Potycarboxylic acid
48 FR 39689

9-1-83
83-1087
Do
G
Sodium poly[1-oxoalkyl-1-amino-2-(tert-butyl-2-sulfonate)-1-osoalkyl-48 FR 40782

l-amino-(N,N-dimethane)]
9-9-83
83-1159
Do
G
Complex epoxy resin adduct
48 FR 41638

9-16-83
83-1162
Do
G
Substituted pyridine
Do
83-1163
Do
G
Do
Do
83-1174
E. 1. du Pont de Nemours & Co., Inc.
G
Monosubstitutedheterocyclediazonium chloride
Do
83-1175
Do
G
Monosubstitutedheterocyclesulfonylisocyanate
Do
83-1211
Do
G
Monosubstitutedheterocyclesultonamide
48 FR 43397

9-23-83
83-1212
Do
G
Monosubstitutedheterocyclesolfonyl chloride
Do
83-1214
Do
G
Oisubstitutedchloromethylsilane
Do
83-1243
CBl
G
Polymer of formaldehyde and substituted phenols and hydrobromic acid Do
83-1305
Do
G
Naphthalene, dialkylated

83-1243
CBl
G
Polymer of formaldehyde and substituted phenols and hydrobromic acid Do
83-1305
Do
G
Naphthalene, dialkylated
48 FR 45842

10-7-83
83-1306
Do
G
Dialkylated naphthalene sulfonic acid
Do
83-1307
Do
G
Dialkylated naphthalene sulfonic acid barium salt
Do
84-30
Do
G
Modified polyethylene ionomer
48 FR 48863

10-21-83
84-98
Do
G
Alkoxy polyol terpolymer
48 FR 50944

11-4-83
84-105
Do
G
Halogenated alkene
Do
84-106
Do
G
Halogenated alkane
Do
84-107
Do
G
Do
Do
84-179
Do
G
Substituted-phenyl-N-substituted-sulfophenylazo-benzylidenehydrazin Do

substitutedamino monochlorotrazinylamino sulfobenzoate-copper

sulfate, sodium salt

84-201
Do
G
Tetrasubstituted dithiadiphosphetane
48 FR 52505

11-18-83
84-221
Do
G
Ethoxylated alkyl quaternary amine
48 FR 54394

12-2-83
84-223
Do
G
Aromatic sulfonate of substituted heteropolycycle
48 FR 55332

12-12-83
84-225
Do
G
Polyester-imide resin
Do
84-232
Spencer-Kellogg Division of Textron
, Inc. G
Alkyd resin
Do
84-290
CBl
G
Reaction product of glycerin, ethylene oxide and hydrocarbyl halide
48 FR 930

1-6-84
84-312
Do

Methyltris(2-methyl-3-butyn-2-oxy)silane
49 FR 1787

1-13-84
84-326
Do
G
Bis(polyalkylaminetriphenyl)-bis)amino-alkyl)benzene
49 FR 2529

1-20-84
84-327
C. J. Osborne Chemicals, Inc.
G
Epoxy ester resin
49 FR 9954

3-16-84
84-334
CBl
G
Polyester-lmlde resin
49 FR 3523

1-27-84
84-336
Westinghouse Electric Corp.

Polymer of melamlne, formaldehyde, o.p-toluenesulfonamide, methyl
Do

glucose, sodium hydroxide, guanidine, carbonate, magnesium bromide.
84-370
CBl
G
(Substituted-heterocycle) alkylamlne derivative
49 FR 4980

2-9-84
84-381
Monsanto Co,
G
Polyphenyl ether
49 FR 6160

2-17-84
84-386
CBl
O
Substituted phenylmagneslum chloride
Do
84-387
Do
G
Substituted benzyl alcohol
Do
84-417
Borg-Warner Chemicals, Inc.
G
Substituted phenol
49 FR 6991

2-24-84
84-420
Fairmont Chemicals Co., Inc.

4-(4,5-Dihydro-4-(5-hydroxy-3-methyl-1-(4-8Ulfophenyl)-1H-pyrazol-4-
49 FR 7654

ylbenzenesulfonic acid-tripotassium salt
3-1-84
84-498
Ethox Chemicals, Inc.
G
Fatty alcohol, ethoxylated, propoxylated, fatty acid ester
49 FR 13746

4-6-84
84-506
CBl
G
Quinoline isolndole derivative
Do
84-510
Do
Q
Halogenated aromatic ester
Do
84-525
Do
G
Sulfo substituted phenyl azonaphthyl dye
Do
84-626
Do
G
Sulfophenyl azonaphthyl dye
Do
84-529
The Southland Corp.
G
Mixed mono and di-amldes of an organic acid
Do
12
-------
84-548
84-580
84-581
84-582
84-584
84-585
84-593
84-605
84-619
84-629
84-632
84-661
84-666
84-668
84-671
84-672
84-674
84-682
84-684
84-693
84-697
84-699
84-705
84-708
84-716
84-745
84-746
84-747
84-749
84-755
84-761
84-772
84-773
84-774
84-775
84-776
84-777
84-778
84-779
84-782
84-783
84-784
84-793
84-795
84-797
84-798
84-799
84-800
84-801
84-802
84-810
CBI
Do
Do
Do
Do
Do
Do
Do
Do
Do
The Sherwin-Williams Co.
The Upjohn Co.
CBI
Do
Do
Do
Do
Do
Do
Do
The Upjohn Co.
CBI
Monsanto Co.
American Hoechst Corp.
Carbodllmlde
Q Isopropyl ester of substituted acetic acid
Q
Q
G
G
G
G
G
G
G
G
G
G
G
G
Oxaspiroalkane
Substituted trlalkylbicyclononene
Methyl alkanoate ester
Alkyl pentanoate ester
Dlazotlzatlon product of substituted benzamlde and substituted pyridine
Polyester
Tetrasubstltuted indolium salt
Modified epoxy resin
D/lsocyanate polyether urelhane prepolymer
Polyurethane plastics
Starch, 2-dlethylamlnoethylene hydrochloride, 2 acetamido-N-(2-
substituted alkvl-)N-methylether
Polyester from carbomonocycllc ester and alkylene glycol
Substltuted-[4,5-dlhydro-3-methyl-5-oxo-(substituted carbomonocycllc)-
1H pyrazol-4-yl)azo]-benzene9ulfonic acid
Reaction product of epoxides and aromatic amine 49 FR 22128
5-25-84
Cuprate (2), [substituted[[[3-dimethylamino]propylJaminoJsulfonyl]-29H Do
31H-phthalocyanine-substituted-sulfonato (4)-NM, N30, N3\ N"]-sodium,
formate
Modified, fatty amidoamine
49 FR 14802
4-13-84
49 FR 16833
4-20-84
Do
Do
Do
Do
Do
49 FR 18034
4-26-84
Do
49 FR 19110
5-4-84
Do
49 FR 20060
5-11-84
Do
49 FR 19110
5-4-84
Do
Polymer of formaldehyde and substituted phenols
Dlthlocarbamate salt
49 FR 21113
5-18-84
Do
49 FR 22128
5-25-84
Do
Do
Polyurethane plastics
Substituted substituted substituted naphthalenedlsulfonlc acid,
sodium salt
Benzeneamine, 2-ethyl-6-methyl-N-methylene Do
polymers, linseed oil, soya oil, phthalic anhydride, isophthallc acid, glycerine,
castor oil, maleic anhydride fumaric acid, oxalic acid, pentaerythriol
CBI
G
Modified alkylphenol resin
Do
Do
G
Fatty alcohol, hydroxy stearate
49 FR 23916

6-8-84
Do
G
Polyalkylene glycols
Do
Do

Do
Do
Do
G
Cyclic ester
Do
Do
G
Aromatic ester
Do
E. I. du Pont de Nemours, & Co., Inc.
G
Polyester/arylic copolymer
Do
Southland Corp.
G
Mixed amidoamine
Do
Do

Do
Do
Do

Do
Oo
Do

Do
Do
Do

Do
Do
CBI
G
Pentasubstltuted naphthalenecarboxamlde
Do
Do

5-Fluorosylfonyl-2-methoxybenzenesulfonyl chloride
Do
Do
G
Polymer of substituted acrylic acid esters and dlsubstituted acrylamldes
Do
Do
G
Disubstltuted anthraquinone-2-sulfonlc acid
Do
Do
G
Carbomonocycllc, carbopolycyclic polyester
49 FR 24782

6-15-84
Do

N-ethyl-N-{4-nltrophenyl)ethanamide
Do
Do

N-[4-(ethylamino)phenyl]methanesulfonamide
Do
Do

N-ethyl-4-nltrobenzenamlne
Do
Do
G
Pentasubstltuted naphthalenecarboxamlde
Do
Do

N-ethyl-N-[4(methylsulfony)amlno]phenyl]ethanamlde
Do
Do
G
Aromatic diamine polymer with epoxy phenol novolac
Do
Do
G
Mixture of saturated terpenes
Do
13
-------
84-815
Do

Polycaprolactone dlol, adduct with modified 4,4'-dlphenylmethane
Do

dllsocyanate and polyproxylated

84-822
Do
Q
Modified Btyrene-dlv nyl benrene polymer
Do
84-326
Do
G
Polymer of aliphatic polyamines, dlhaloalkane, aliphatic diacid 49 FR 25676

6-22-84
84-827
Do
a
Polymer of aliphatic polyamlries, dihaloalkane, organic diamine
Do
84-828
Do
G
Polymer of substituted polyalkylene polyamine and substituted alkane
Oo
64-830
E. du Port de Nemours S Co., Inc.
G
Styrene, nitrite acrylic copolymer
Do
64-831
Do
G
Styrena acrylic copolymer
Do
84-882
Do
a
Acrylic polymer
Do
84-838
CBI
0
Tetrasubstituted naphlhalenecarboxamide
Do
84-843
Do
a
Modified epoxy prepolymer
Do
84-844
Do
a
Amine salt of a styrenedivinyl benzene ion exchange resin
Do
84-846
King Industries, inc.
a
Fatty acids, compound with diamines
Do
84-847
Dlslritex inc.
G
Acrylic copolymer, sodium salt
Do
84-882
CBI
G
Functions: polymer of mixed acrylate and methacrylate based monomers
49 FR 28800

6-29-94
84-B54
Do

(1,1 ':3,1"-T erpheny IO-2'-ol-5'-(octadecyloxy) ,-4-n-octadecyloxy-2,6-
Do

diphenylphenol

84-857
Do

Polymer of epichlorohydrin-bisphenol-A polymer, bisphenol-A,
Do

ethyltriphenyi phosphnium iodine, formaldehyde, n-butyl alcohol,

triethylamine and phthalic anhydride

84-859
Do
a
Halophthalimlde
Do
84-664
Oo
G
Vinyl ecetale-acrylate copolymer
Do
84-865
Do
G
((AlkylMalkyl)amlno)poiYalkoxy ether sulfate halfester
Do
84-868
Albright end Wilson Inc.
G
Alkyl methacrylate polymer
Do
84-88?
Do
G
Do
Do
84-888
Do
G
Oo
Do
84-888
CBI

4-ic acid
Do
84-877
Do
G
Polyamlde polyether polymer
49 FR 26614

7-13-84
84-883
Hach Corp

1,10-Phenanthroline 1:1 salt with p-toluene sulfonic acid (p-TSA)
Do
84-888
CBI
G
Substituted styrene
Oo
84-889
Do
G
Substituted benzaldehyde
Oo
84-898
Hercules Inc.
G
Polyester polyol
Do
84-014
CBI

Benzoic acid, 4-hydroxy-3-me
-------
84-1030
Do
G
Poly(alkylsuccinlc diester)
49 FR 33718
8-24-84
84-1031
Do
G
Do
Do
84-1033
Ethyl Corp.
G
Alkylated phenol
49 FR 32110
8-10-84
84-1034
CBI
G
Mercaptocarboxiic acid ester reaction product with olefin
Do
84-1058
Do

Polymer of diethylene glycol, maleic anhydride, benzoic acid
49 FR 33721
8-24-84
84-1059
Do
G
Fluoropolyester modified toluene dilsocyanate polymer
Do
84-1069
Do
G
Substituted ether of alkoxylated fatty alcohol
Do
84-1099
Molecular Rearrangement, Inc.

4-Aniniio-4'-hydroxy azo benzene
49 FR 34572
8-31-84
84-1107
CBI
G
Copper complex of a substituted biphenyl sulfonated salt
49 FR 35414
9-7-84
84-1115
Do
G
Phenolic modified rosin ester
Do
84-1123
Do
G
Substituted sulfonated naphthalene
Do
84-1140
Do
G
Monobasic acid-modified alkyd resin
Do
84-1142
C. P. Mall Co.
G
Aliphatic polyester
Do
84-1169
CBI
G
Phenol, benzylic ether
Do
84-1201
Do
G
Polyamlne amide imlde
49 FR 38356
9-28-84
•The generic name is the name that was provided by the submitter when the corresponding PMN was filed. A different generic name may be assigned to the
compound by EPA when published in the TSCA Inventory of Chemical Substances.
15
-------
TSCA Assistance Office (TS-799)
Office of Pesticide & Toxic Substances
U.S.E.P.A.
Washington, D.C. 20460
Official Business
Penalty for Private Use
$300
First Class Mail
Postage and Fees Paid
EPA
Permit No. Q-35
THE TSCA CHEMICALS-IN-PROGRESS
BULLETIN
-------