as.
Office of Toxic Substances
(OTS)
Vol. 6, No. 4	October 1985
INSIDE
What's Happening in OTS by Don R. Clay, OTS Director
OTS Issues Information-gathering Rule to Support OSW	Page 2
OTS Plays Important Role in "Spy Dust" Case	Page 2
At Work - Frank Kover	Page 2
EPA ASKS OSHA to CONSIDER REGULATING 4,4'-MDA	Page 3
EPA FURTHER RESTRICTS PCB TRANSFORMER USE	Page 3
PETITION FILED by CHICAGO AREA GROUPS DENIED	Page 4
ASBESTOS PUBLICATIONS AID BUILDING OWNERS and CONTRACTORS	Page 4
EPA FINES 7 CORPORATIONS	Page 4
EPA ACCEPTS CONSORTIUM PLAN to TEST TCEA	Page 4
EPA SEEKS VINYL ACETATE HEALTH and SAFETY DATA	Page 5
EPA DECIDES NOT TO TEST CARBOFURAN INTERMEDIATES	Page 5
ADVISORY URGES MINIMIZING WORKER EXPOSURE to MBOCA	Page 8
DATA on ITC CHEMICALS RECEIVED	Pa9e 8
FOR YOUR INFORMATION
OTS Seeks Data for CHIPs	Page 5
OTS Receives 19 Initial FYI Submissions	Page 6
EPA Plans TSCA Conference for Small Business Managers	Page 8
This news bulletin is intended to inform all persons concerned with the Toxic Substances Control Act (TSCA) about recent
developments and near-term plans. For further information or tQ request copies of documents mentioned, write the TSCA
Assistance Office (TAO), (TS-799) EPA, Washington, D.C. 20460 fheTAO also has a toll-free telephone number (800) 424-9065.
In the Washington D.C. area, or from outside the continental Un!tec| states call (202) 554-1404.

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What's Happening in OTS - Don R. Clay
OTS Issues Information-Gathering Rule to Support the Office of Solid Waste
As many of you already know, TSCA has truly unique information-gathering authori-
ties. We can require industry to provide us with available risk data or to perform
needed tests. Until recently, we have used these authorities to gather information
that OTS needs. As our experience under TSCA has grown, it has become increas-
ingly clear that these authorities can also be used effectively to support the informa-
tion needs of other EPA programs and other Federal agencies. Our first such rule was
proposed last month to support the EPA Office of Solid Waste (OSW) land disposal
restriction activities.
The TSCA-proposed rule would require industry to provide all available unpublished
health and safety studies on 33 chemicals. OSW needs these data to help them
decide whether to ban the land disposal of these chemicals. We expect to finalize this
rule shortly and to have the available health and safety data in hand by January of
1986.
OTS is prepared to meet future data needs for other programs in the same rapid
fashion.
OTS Plays Important Role in "Spy Dust" Case
Most of you are aware of the recent disclosure by the State Department of the Soviet Union's use of potentially-harmful chemicals
to "track" United States personnel in the Soviet Union. Far fewer, I suspect, are aware of OTS's role in support of the State
Department. The "spy dust" case, as it was dubbed by the media, illustrates the high calibre scientific capability that OTS has.
Several OTS officials along with representatives of the National Institutes of Health were called to the State Department to discuss
a chemical substance, 5-(4-nitro phenyl), 4-pentadien-1-AL or NPPD. All we knew was the chemical name and topic of the meeting.
In preparation for the meeting, we searched the available data but turned up nothing. Our next step was to have the structure
evaluated by the Structure/Activity Team (SAT) in the OTS new chemical program. That is, our experts used available data on
chemicals of similar structure to try to predict the chemistry, absorption, reactivity and potential mutagenicity of NPPD—all of this
in a matter of a few hours. Clearly, unique capabilities had been applied to this potential problem.
Members of SAT along with the OTS staff involved in exposure assessment were called to evaluate the limited data which had been
provided by the State Department. Chemistry and minimal toxicology data confirmed concerns raised earlier regarding both
reactivity and potential mutagenicity of the substances. This was a case so similar to our every day evaluation of chemicals that it
seemed routine.
OTS management and staff representatives traveled to Moscow to speak first hand with Embassy personnel and to collect samples
to address the questions of magnitude and extent of exposure.
"Spy Dust," though not much different from many cases of substances evaluated by OTS, provided an unique opportunity for EPA
scientists and management to demonstrate their skills to an alternative and very concerned audience. All who participated should
be proud of their role.
Frank D. Kover is Chief of the Chemical Screening Branch
(CSB) in the Existing Chemical Assessment Division (ECAD).
CSB is responsible for information-gathering and initial
assessment activities to support the existing chemicals pro-
gram in OTS and in other EPA programs. CSB develops TSCA
section 8 reporting and recordkeeping rules and section 5
existing chemical significant new use rules in order to obtain
	 data needed by OTS or other
EPA offices for risk assessment/
AT WORK	management activities. Such
	 rules require manufacturers,
importers, and processors of substances and mixtures to
report information on use, production, exposure, environ-
mental and health effects, disposal, and allegations of signifi-
cant adverse reactions to health and the environment.
Under Frank's direction, the CSB's staff of about 25 scientists
and analysts screen a wide variety of chemical substances.
Based on existing information and knowledge of their chemi-
cal structure/biological activity relationships, they may iden-
tify a limited number that may present potentially significant
human health or environmental risks. The sources they use
include section 8(e) substantial risk notices, FYI submissions,
and information gathered under section 8 rules, as well as the
published literature. If a chemical turns out to be of potential
concern, Frank's branch may prepare a Chemical Hazard
Information Profile (CHIP). Subsequently, the CHIP may be
referred to the OTS Risk Analysis Branch for further data-
gathering, testing, or assessment within ECAD. (see page 5
for the latest CHIP information).
Recent noteworthy activities in CSB include the development
of hazard profiles on potential substitute chemicals for sub-
stances under consideration in OTS for risk management
action and the development of a Comprehensive Assessment
Information Rule (CAIR).

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EPA Asks OSHA To Consider Regulating 4,4'-MDA
In July, EPA referred a report on 4,4-methylenedianiline (4,4'-
MDA) to the Occupational Safety and Health Administration
(OSHA) for possible regulation of the chemical. The report
describes the risks of 4,4'-MDA and asks OSHA to respond
within 180 days of publication of the notice in the Federal
Register (July 5,1985). EPA asked OSHA to make findings of
unreasonable risk and of that Agency's authority to prevent or
reduce that risk.
In the referral notice (50 FR 27674) EPA said based upon the
weight of available evidence it classifies 4,4'-MDA as a proba-
ble human carcinogen. Because all known exposure to 4,4'-
MDA occurs in the workplace, EPA, exercising its referral
authority under section 9 of TSCA, gave OSHA prior oppor-
tunity to regulate exposures to the chemical. Section 9 pro-
vides a mechanism to resolve problems of regulating risks
under overlapping Federal laws.
About 97 percent of the 400 million pounds of 4,4'-MDA pro-
duced in the United States each year is converted directly, in
enclosed systems, to methylene diphenyl diisocyanate (MDI).
The MDI is used to make polyurethane foams and elastomers.
Human exposure is low in the closed system manufacture of
4,4'-MDA and in the preparation of MDI.
Higher exposure concerns are for the 3 percent of 4,4'-MDA
produced in pure form and packaged for other uses, such as
epoxy curing agents, high temperature wire coatings, poly-
urethane coreactants, dyes, pigments and defense applica-
tions. The higher exposure occur largely from the dust liber-
ated in handling pure4,4'-MDA In the non-MDi uses. Exposure
occurs from both dermal contact and inhalation.
About 600 workers are involved in the manufacture of 4,4'-
MDA. However, EPA believes the total exposed population
may be as high as 13,000. Six U.S. corporations manufacture
4,4'-MDA, and EPA estimates users may number up to 300
firms.
OSHA may respond to the EPA report in several ways. If
OSHA does not act or decides that it does not have the author-
ity to sufficiently reduce the risk, EPA may then take whatever
action it can under its regulatory authorities. If OSHA con-
cludes it does have the authority to reduce the risk sufficiently
OSHA has three alternatives:
•	Declare that the risk is not unreasonable. Under the law,
this precludes EPA from taking regulatory action.
•	Decide that the risk is unreasonable and begin regulatory
action within 80 days. This precludes EPA from taking
regulatory action.
•	Decide that the risk is unreasonable, but chooses not to
begin action within 90 days. In this situation EPA may
take regulatory action.
Commencement of Manufacture Notices
Recently EPA received 39 "Commencement of Manufac-
ture" notices for new chemicals and published the list
in the August 9,1985 Federal Register (50 FR 32294).
Until now the monthly list was reprinted In the Chemi~
cals-in-Progress Bulletin. Beginning with this issue the
Bulletin will no longer reprint the list, but the TSCA
Assistance Office (TAO) will mail each monthly list to
those who call or write the TAO and request that their
names be added to the Commencement of Manufac-
ture mailing list.
EPA Further Restricts PCB Transformer Use
On July 17,1985, EPA took action to reduce fire-related risks
posed by the use of PCB Transformers, units containing 500
parts per million (ppm) or more of polychlorinated biphenyls.
This rule amends portions of the existing PCB electrical
equipment rule by placing additional restrictions and condi-
tions on the use of PCB Transformers.
The rule was prompted by EPA's concern over risks resulting
from fire-related incidents involving PCB Transformers in
Chicago, San Francisco, and Binghampton, New York. Fires
involving PCB Transformers can cause the rupture of the
transformer, the release of PCBs, and the formation and dis-
tribution of PCBs and toxic incomplete combustion of PCBs.
The products formed from the incomplete combustion of PCB
dielectric fluid may include 2,3,7,8-tetrachlorodibenzofuran
(2,3,7,8-TCDF) and 2,3,7,8-tetrachlorodibenzo-p-dioxin
(2,3,7,8-TCDD). When PCB Transformer fires occur in or near
buildings, particularly commercial buildings, building occu-
pants, as well as emergency response personnel, cleanup
crews, and members of the general public, can be exposed
and thus are at risk.
EPA defines commercial buildings to include all types of
buildings other than industrial facilities and would include
locations such as office buildings, shopping centers, hospi-
tals, and colleges. For the purposes of the rule, a PCB Trans-
former located "in or near" a commercial building is defined
as one within the interior of a commercial building, on the roof
of, attached to the exterior wall of, in the parking area of, or
within 30 meters of a commercial building.
In the rule (50 FR 29170) EPA:
•	Prohibits by October 1,1985, further installation of PCB
Transformers in or near commercial buildings;
•	Requires by December 1,1985, the registration of all PCB
Transformers with fire response personnel and building
owners;
•	Requires by December 1, 1985, the removal of stored
combustibles located near PCB Transformers;
•	Requires by December 1, 1985, that the access (e.g.,
vault door, machinery room door, hallway, etc.) to a PCB
Transformer be marked;
•	Prohibits by October 1,1990, the use of higher secondary
voltage (480 volts and above) network PCB Transformers
in or near commercial buildings;
•	Requ ires by October 1,1990, the installation of enhanced
electrical protection on lower secondary voltage network
PCB Transformers and higher secondary voltage radial
PCB Transformers in use in or near commercial
buildings.
EPA also is requiring the owners of PCB Transformers
involved in fire-related incidents to notify immediately the
National Response Center and to take measures as soon as
practicable and safely possible to contain any potential
releases of PCBs or incomplete combustion products in
water.
The July 17, 1985 rule does not have any effect on PCB-
Contaminated transformers, which are defined as trans-
formers with PCBs in amounts between 50 and 500 ppm.
3

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Petition Filed by Chicago Area Groups Denied
EPA denied a petition filed by two Chicago-based citizens'
groups that asked the Agency to issue a rule under section 4
of TSCA requiring scientific testing of certain substances and
mixtures for their combined health and environmental effects.
The substances and mixtures were identified as environ-
mental pollutants in Southeast Chicago, an area of high
industrial concentration. The petition was filed under section
21 of TSCA by the Citizens for a Better Environment and by
Irondalers Against the Chemical Threat.
The petition, filed on April 23,1985, asked EPA to investigate
firms in Southeast Chicago that manufacture, distribute, pro-
cess, use or dispose of coke oven emissions, benzene, chrom-
ium, arsenic, cadmium, nickel, toluene, xylene, acetone,
copper and lead and require them to test for environmental
and health effects. For an explanation of citizens' petitions
under section 21 of TSCA see page 7.
In a July 26, 1985 denial (50 FR 30517) the Administrator said
that in order to issue a testing requirement rule under section
4, EPA must specify standards for the development of the test
data. To date no standards exist for testing multiple chemicals
for their toxicological interactions, and there is not enough
scientific knowledge to specify how testing of multiple pollu-
tants for their combined health effects should be done or how
to ensure that the data from these tests will be reliable.
The Administrator said EPA is aware of the importance of
considering the potential added health and environmental
risks posed by multiple chemical exposures, and that the
Agency has ongoing and planned activities to address this
area of concern. He cited EPA's "Proposed Guidelines for the
Health Risk Assessment of Chemical Mixtures" (50 FR 1170).
These guidelines (when published in the fall of 1985) will be
useful for the assessment of cumulative risks posed by mix-
tures of toxic chemicals such as those cited by the petitioners.
However, the Administrator said the available toxicity infor-
mation for mixtures on which the guidelines will be based will
not allow for the estimation of synergistic or antagonistic
effects. Synergistic effects refer to total effects being greater
than the sum of the effects taken independently. Antagonistic
effects refer to the interaction of two or more chemicals com-
ing together.
Asbestos Publications Aid Building Owners and Contractors
OPTS is distributing two publications to aid building owners
and custodians in the inspection, evaluation, and control of
asbestos hazards in buildings.
The first publication, "Guidance for Controlling Asbestos-
Containing Materials in Buildings" will help building owners
set priorities in dealing with asbestos-containing materials.
The document, informally called the "Purple Book," is a revi-
sion of the 1983 "Guidance for Controlling Friable Asbestos-
Containing Materials in Buildings."
A second document, "Asbestos In Buildings: Guidance for
Service and Maintenance Personnel," is designed for custo-
dians and other building workers to become familiar with
types of materials that could contain asbestos and safe work
practices to employ in dealing with those materials. EPA is
working closely with the Service Employees International
Union and other labor groups to distribute the booklet.
EPA Fines Seven Corporations
In July EPA fined seven corporations for failing to comply
with the reporting requirements of section 8(a) of TSCA. Six
of the violations involved asbestos reporting failures. The
violations all took place in 1982. The Ford Motor Co., the
seventh corporation, was fined $25,000 for failing to file a
required TSCA report on an imported chemical.
"The reporting requirements of the Act (TSCA) are the founda-
tion of EPA's chemical regulatory activities," said Dr. John A.
Moore, Assistant Administrator for Pesticides and Toxic Sub-
stances. "Without such data EPA cannot act to protect the
public from potentially dangerous su bstances. That is why we
take these violations so seriously."
The six firms fined for violating TSCA asbestos rules are the
Raymark Corp., of Trumbull, Connecticut, $25,000 for report-
ing two years late on how it used its asbestos; Empire Ace
Insulation Manufacturing Corp., of Brooklyn, New York,
$25,000 for failing to file an asbestos report; Allpax Company,
Inc., of Mamaroneck, New York, $25,000 for failing to report
its asbestos manufacturing and use activities for two years;
Atlantic Gasket Inc., of Philadelphia, $25,000 for failure to
meet asbestos reporting requirements; Economy Die and
Gasket Company, Inc., of Baltimore, $10,000 for failure to
meet asbestos reporting requirements; Phelps Packing and
Rubber Co., of Baltimore, $25,000 for failing to meet asbestos
reporting requirements.
Persons violating provisions of TSCA may be fined up to
$25,000 a day for each day a violation continues. When deter-
mining the size of a penalty, EPA takes into account the
circumstances surrounding the violation and the number of
days the violation existed. Once a civil complaint is issued by
EPA, a company may contest the facts in the complaint or the
size of the penalty. EPA will reduce the penalty if a firm can
provide documentation showing an inability to pay or an
inability to continue the business upon payment.
EPA Accepts Consortium Plan to Test Toxic Effects of TCEA
EPA is proposing that an industry consortium's protocols and
schedule submitted for testing the toxic effects of 1,1,1-
trichloroethane (TCEA) be adopted as the test standards for
the chemical.
The EPA August 7, 1985 proposed rule (50 FR 31895) is an
outgrowth of a section 4(a) rule published on October 10,
1984 requiring testing of TCEA for developmental^ toxic
effects.
The consortium, known as the Halogenated Solvents I ndustry
Alliance (HSIA) will conduct a full developmental toxicity
study on rats and rabbits, as proposed by EPA. The studies
will be conducted in accordance with TSCA's Good Labora-
tory Practice Standards. The HSIA consortium includes Dow
Chemical Co.; ICI America, Inc.; PPG Industries, Inc.; and
Vulcan Materials Co.
I n 1981, TCEA (71-55-6) was designated by the ITC for prior-
ity testing consideration under section 4 of TSCA. For an
explanation of section 4, see page 7.
'4

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EPA Seeks Unpublished Data on Vinyl Acetate
On August 8,1985, EPA proposed a rule that would require
past, current and prospective manufacturers, importers and
processors of vinyl acetate to provide EPA with lists and
copies of unpublished health and safety studies on the chem-
ical (50 FR 32095). Vinyl acetate is a major industrial chemical.
It is prepared from petrochemicals and polymerized and
copolymerized with other monomers to produce a wide var-
iety of plastics and resins. EPA estimates the current annual
production of vinyl acetate at 1.9 billion pounds and importa-
tion at 15 million pounds. People are exposed to vinyl acetate
during its manufacture, importation and processing as well as
from the use of consumer products made of vinyl acetate
polymers. The Agency will use the information to support a
detailed assessment of the health and environmental risks of
vinyl acetate. For additional information on section 8(d), see
page 7.
EPA Decides Not to Test Carboturan Intermediates
EPA is not initiating rulemaking at this time to require testing
of carbofuran intermediates (CIs). In December 1982 the
Interagency Testing Committee (ITC) recommended to EPA
that it consider CIs for testing but did not designate that EPA
respond within 12 months. The ITC recommended chemical
fate and environmental effects testing for the CIs.
EPA said in a July 22, 1985 notice (50 FR 29761) it did not
believe on the basis of available data that there is reason to
find that "these chemicals may present an unreasonable risk
of injury to the environment" nor did the Agency find "that
there is or may be substantial environmental release."
The three chemicals in the CI group are:
•	Methallyl-2-nitrophenyl ether (NINE)	13414-54-5
•	7-Nitro-2,2-dimethyl-2,3-	13414-55-6
dihydrobenzofuran (NDD)
•	7-Amino-2,2-dimethyl-2,3-	68298-46-4
dihydrobenzofuran (ADD)
The ITC recommended chemical fate testing for the CIs with
emphasis on environmental monitoring. The ITC said there
was insufficient Information to characterize the nature of dis-
persion concentration and persistence of CIs in the environ-
ment.
The environmental effects testing recommended by the ITC
included acute toxicity to fish and aquatic Invertebrates. The
ITC said that concentrations of CIs in wastewater effluent
released to the aquatic environment were believed to
approach the concentrations of CIs reported to cause acute
effects in goldfish and possibly exceed levels for more sensi-
tive species.
In evaluating the ITC's testing recommendations for the CIs,
EPA considered all available relevant information including
production volume, use, exposure and release information
reported by the only manufacturer of CIs In the United States.
That manufacturer, FMC Corporation, gave EPA its CIs pro-
duction volumes for 1982 on a confidential business informa-
tion basis. FMC produces CIs only at a Baltimore, Maryland,
Plant, and the production Is used as intermediates.
For an explanation of the testing under section 4 of TSCA and
the role played by the ITC. see page 7.
OTS Seeks CHIP Data
OTS is asking the public for unpublished information about
the following chemical:
Hexafiuoroisobutyiene	382-10-5
This chemical has been selected for preliminary assessment
review. OTS has preliminary information about potential
effects of this chemical to health and the environment and is
doing a review to find what other information is available
about this chemical. Information should be sent to:
TSCA Document Control Office (TS-793)
ATTN: Mr. Terry O'Bryan
U.S. Environmental Protection Agency
Washington, D.C. 20460
Persons who have unpublished data about the chemical, but
who also want answers to questions prior to responding
should contact John Leitzke of the OTS Chemical Screening
Branch, (202) 382-3507, as soon as possible.
All information submitted in response to the solicitations will
be placed in a public file and made available for public inspec-
tion, unless the submitter is able to assert a claim of confiden-
tiality, in accordance with the provisions of section 14 of
TSCA. EPA will handle all confidentiality claims in accord-
ance with its procedures governing the confidentiality of bus-
iness information.
The OTS review of the chemical, when completed, will be in a
report called a Chemical Hazard Information Profile (CHIP). A
CHIP is a brief summary of readily available information con-
cerning the health and environmental effects and potential
exposure to a chemical. CHIP candidates are chosen on the
basis of information indicating a potential for adverse health
or environmental effects along with evidence of a significant
production or some type of exposure.
When OTS searches the literature in preparing a CHIP it
generally limits the search to automated data bases and refer-
ence works. But OTS encourages individuals and firms to
submit unpublished or recently published reports and all
other hard-to-obtain studies on the chemical selected for a
CHIP. Relevant studies from the public coufd include data on
health effects, environmental effects, commercial production
and uses, exposed populations, environmental levels, or any
other material that can aid in theassessment of the chemical's
Impact on health or the environment. OTS is also interested in
knowing of current testing of a CHIP candidate or assessment
activities by other oeg*cUzftttoR8»«
The TAO is distributing copies of the recently com-
pleted CHIP:
Methyl Bromide	74-83-9
OTS encourages comments on the accuracy and tbor*
oughness of information presented in the CHIP.
The format of the Chemicals-in-Progr&ss Bulletin has
changed gradually in 1985. Our aim is to help readers
quickly acquire the TSCA information they need. If you
have suggestions on how the Bulletin can be improved
to help you, please send your ideas to:
Joe Boyle
Editor
Cfremlcals-in-Progress Bulletin
TS-789
Washington, DC 20460
5

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Latest FYI Submissions
EPA received in recent weeks initial FYI (For Your Informa-
tion) submissions listed below. For additional information on
FYls see page 7.
Document Control No. FYI-
Chemical Name(s)
OTS-0485-0315
Permatox 100 pesticide
CAS No.
Mixture
Case history associated with occupational exposure
OTS-0585-0407 S
Halogenated pyridine compounds
Summarized final results from a probe
teratogenicity study in rats
Confidential
AX-0685-0410
NEODOL alcohols and derivatives
Information bulletins on human and aquatic safety/
hazards of a surfactant class
Several
AX-0685-0411
Light catalytic cracked distillate	64741-59-9
Final report of inhalation acute toxicity tests
in rats
OTS-0685-0412
4,4'-Methylenebis (benzenamine) polymer 67786-32-7
with methyl oxirane
Final reports from a battery of genotoxicity tests
AX-0685-0413
Acetaldehyde
Carbon tetrachloride
Final report from a 4-week inhalation toxicity test
in rats using interrupted and uninterrupted
exposures
OTS-0685-0414
Hydrogen chloride
Final report from a 90-day inhalation toxicity test
in rats and mice
OTS-0685-0415
Methacrylic acid
Final report from a 90-day inhalation toxicity test
in rats and mice
OTS-0685-0416
Benzene
Final report from acute inhalation tests in rats
and mice to determine genotoxicity
AX-0685-0417
Unleaded gasoline
Report from an epidemiology feasibility study
AX-0685-0418
Petroleum refinery chemicals
Report from an epidemiology feasibility study
OTS-0685-0419
Very fine diameter fibrous glass
Summarized results from an intraperitoneal study
in rats to determine carcinogenic effects
OTS-0685-0420 S
An R&D pesticide	Confidential
Preliminary results from a 2-year dietary
oncogenicity and chronic toxicity study in mice
75-07-0
56-23-5
7647-01-0
79-41-4
71-43-2
8006-61-9
Unknown
Unknown
OTS-0685-0421
Polychlorinated styrenes
Information for CHIP in preparation
OTS-0685-0422
Triphenyl phosphite	101-02-0
Information for CHIP in preparation
OTS-0785-0423
Elemental yellow phosphorus	7723-14-0
Summarized final results from a one generation
gavage reproductive study in rats
OTS-0785-0424
s-n-Butyldiamidophosphorothioate	Unknown
Final report from an acute oral toxicity test
in rats
OTS-0785-0425
Vinylidene fluoride	75-38-7
Preliminary results from a 13-week inhalation
toxicity test in rats to determine reproductive
and other target organ effects
AX-0785-0426
Petroleum refinery streams	Several
Preliminary report from a lifetime dermal
carcinogenicity/chronic toxicity study in mice
Section 8(e).. .Substantial Risk
Below is a list of recent initial section 8(e) notices placed in
EPA's public file. For an explanation of section 8(e) and how
copies of notices can be acquired see page 7.
Log No. 8EHQ-	[CAS No.]
0585-0555
Brominated diphenyloxide with	36483-60-0
bromination ranging mainly from 6 to 9	68928-80-3
bromines per molecule	32536-52-0
per molecule	63936-56-1
Abbreviated final report from an oral rat
teratology study
0585-0556 S
Complex methacrylate monomer mixtures
Results of a 2-week repeated dermal study in rabbits
0585-0557
Oil refinery products
10-year worker retrospective mortality study report
0685-0558 S
Substituted oximidoalkane
Final results of a battery of in vitro genotoxicity studies
0685-0559 S
T ris(dlmethylamino)silane	15112-89-7
Results of new and previously conducted acute
inhalation toxicity studies in rats
0785-0560
Acrylamlde monomer
Preliminary results from an ongoing 2-generation
reproduction/dominant lethal study In rats
0785-0561
1 -Ethenyl-2-pyrrolidinone
Results of several in vitro and in vivo toxicity
studies
79-06-1
88-12-0
29082-74-4
61225-61-0
S at the end of a Log Number means a sanitized version is
available
6

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Below are explanations of sections of TSCA that are cited in this issue of the Bulletin. For additional information about TSCA's
provisions, call (800) 424-9065 or write the TAO.
Testing ol Chemical Substances and Mixtures.. .Section 4
Section 4 of TSCA gives EPA authority to require manufac-
turers or processors of chemicals to test the toxic effects of a
designated substance. To require testing EPA must find that
the chemical may present an unreasonable risk; that there are
insufficient data available with which to perform a reasoned
risk assessment; and that testing is necessary to generate
such data. A test rule may also be based on an EPA finding of
substantial production and exposure to humans or the envi-
ronment, in addition to findings of insufficient data and need
for testing.
Under section 4(e) an Interagency Testing Committee (ITC)
was established to recommend chemicals to EPA for priority
consideration for the promulgation of section 4 test rules.
Besides recommending, the ITC can additionally "designate"
the chemicals, in which case EPA must respond to the desig-
nation within 12 months by starting rulemaking under section
4 or giving reasons for not doing so. The ITC can designate up
to 50 chemicals or categories of chemicals for testing and
must make revisions to this section 4 priority list as needed.
The ITC is made up of appointed members from eight Federal
agencies, as specified in TSCA. Representatives from six
additional Federal agencies serve in a liaison capacity.
For Your Information
For Your Information (FYI) submissions are notices submit-
ted voluntarily to the Agency or the Office of Toxic Substan-
ces on chemical toxicity and/or exposure. FYls are submitted
by chemical manufacturers, processors and distributors,
trade associations, labor organizations, Federal, State and
local agencies, foreign governments, academia, public inter-
est and environmental groups, as well as the general public.
Microfiche copies of these submissions are located in the
OTS Public Reading Room, first floor, East Tower, Waterside
Mall, 401 M Street, S.W., Washington, D.C. To obtain a copy of
an FYI, follow the procedure outlined above for TSCA section
8(e) submissions.
Health and Safety Data Reporting.. .Section 8(d)
Section 8(d) ol TSCA authorizes EPA to promulgate rules on
speciiic chemicals and categories of chemicals that require
manufacturers, importers, and processors to submit lists and
copies of health and safety studies that they initiate or con-
duct, know about or can reasonably discover.
Section 8(e)...Substantial Risk
Under section 8(e), persons who obtain new information that
reasonably supports the conclusion that a substance which
they manufacture, import, process or distribute presents sub-
stantial risk of injury to human health or the environment must
notify EPA within 15 working days. These notices are then
reviewed by the Office of Toxic Substances (OTS) and an
initial evaluation (status report) is prepared containing, if
appropriate, followup questions to the submitter, referrals to
other agencies, and recommended OTS/EPA followup
actions. The 8(e) notices represent a company's first review of
a situation and a judgment in compliance with the statute to
submit a notice within 15 working days of obtaining the infor-
mation. See page 6 for the latest section 8(e) notices.
EPA publishes its status reports to make 8(e) information
widely available and understandable to a broad public. The
submissions and status reports are located in the OTS Public
Reading Room, first floor, East Tower, Waterside Mall, 401 M
Street, S.W., Washington, D.C.
Persons wishing to obtain a copy of a section 8(e) notice may
write: EPA, Freedom of Information, Ms. Jeralene Green, (A-
101). Washington, DC, 20460. There is no charge forduplicat-
ing the first 49 pages, but at page 50 of a request for
duplication there is a $10.00 fee and a 20 cent charge for each
additional page (e.g., 51 pages cost $10.20).
Single copies of the section 8(e) status reports (not the full
submission) are available from the TAO.
Citizens' Petltion...Sectlon 21
Any person may petition the EPA Administrator to begin a
proceeding for the issuance, amendment or repeal of a rule or
order under sections 4,5,6, or 8 of the Act. The Administrator
may hold a public hearing, conduct an investigation or pro-
ceeding to determine if the petition should be granted. If
granted, EPA must begin promptly an appropriate proceed^
Ing. If denied, EPA must publish in the Federal Register the
reasons for the denial. If there is a denial, the petitioner may
begin a civil action in a Qistrfpt Court to compel EPA to
start an appropriate proceeding. The civil action must be filed
within 60 days of the Administrator's denial, If the Administra-
tor fails to grant or deny the petition within 00 days after the
petition is filed, the petitioner may file a civil action with the
District Court within 60 days following the expiration of the
90-day response period.
7i

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OTS Plans TSCA Conference for Small Businesses
As the Bulletin was going to press it was learned that
the Office of Toxic Substances will sponsor a one-day
TSCA Smalt Business Conference, on December 10 or
11, in the greater New Brunswick, New Jersey area. The
conference will stress what small business managers
must know about TSCA and their obligations to comply
with provisions of the Act. If there is enough interest a
subsession workshop on the premanufacturing notice
provisions of TSCA (PMN section 5) will be held. The
workshop will include filling the PMN forms.
Preregistration will be required. For more details call
the TAO information specialists (800) 424-9065, after
November 1, or write: Edward A. Klein, Director, TAO,
TS-799, Washington D.C. 20460.
Persons interested in an outline of the studies received should
read the August 7, 1985 notice. Persons who want copies of
the data submissions should write: EPA, Freedom of Informa-
tion, Ms. Jeralene Green, (A-101), Washington, DC 20460,
There is no charge for duplicating the first 49 pages of a study,
but at page 50 of a request for duplication there is a $10.00 fee
and a 20 cent charge for each additional page (e.g., 51 pages
cost $10.20). For additional information on section 4 and the
ITC see page 7.
EPA Receives Data on ITC Chemicals
EPA recently received test data on six chemicals, all of which
are subjects of section 4 negotiated testing programs [August
7, 1985 (50 FR 31919)],
Each of the chemicals originally was recommended to EPA
for priority consideration for testing by the ITC. The chemi-
cals with the approximate n umber of pages of each report are:
2-Chlorotoluene
35
pages
1,3-Dioxolane
30
pages
Oleylamine
125
pages
Formamide
220
pages
2-Phenoxyethanol
50
pages
Tris (2-ethylhexyl) trimellitate
15
pages
Advisory Urges Minimizing Worker Exposure to MBOCA
A chemical advisory urging manufacturers of polyurethane
products to minimize worker exposure to 4,4'methylene-bis
(2-chloroaniline) was issued by EPA in June 1983. TheehWW®'
ical also known as MBOCA (CAS No. 141-14-4), has been
shown to cause cancer in laboratory animals. On the basis of
these studies EPA considers MBOCA to be a probable human
carcinogen, although available data on cancer in humans are
inconclusive, The EPA advisory reports that workers can be
exposed through inhalation or ingestion of MBOCA's dust
particles or through skin absorption. The advisory recom-
mends engineering controls, protective clothing and im-
proved work practices. Copies of the MBOCA advisory are
available through the TAO.
TSCA Assistance Office (TS-799)	official Businm
Office of Pesticide & Toxic Substances	,0'p,w,wu"
U.S.E.P.A.
Washington, D.C. 20460
Flnt Clan Mail
Portage and Feel Paid
EPA
Permit No. G-36
THE TSCA CHEMICALS-IN-PROGRESS BULLETIN

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