£PA/600/N-94/015
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY
Region XX, New York, New York 10278
DATE:
SUBJECT:
FROM:
September 16, 1994
Risk Assessment Review
P.E.
nistrator
William J. MtfSzyns
Deputy Regional A
William Farland, Ph.D.
Director
Office of Health and Environmental Assessment
Attached is a copy of the Risk Assessment Review, a bimonthly
publication that is a cooperative effort between the Office
of Research and Development and the Regional Risk Assessment
Network.
The Review serves as a focal point for information exchange
among the EPA risk assessment community on both technical and
policy issues related to' risk assessment. It is currently in
its fourth year of publication and we are pleased at the
positive feedback we've received on the Review's usefulness
to staff across the Agency.
Thanks to all of you who continue to contribute articles and
are involved with production efforts. If you have an article
to contribute or any suggestions for further issues, contact
one of the Committee members listed on page l of the Review.
Attachment

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September 1994
L Special Features
Availability of Draft Dioxin Reassessment
Documents
kyDnUl
>(202)2&-4S36
On September 13. 1994, EPA made available for public
review its draft reassessment of dtarin human health risks.
This draft reassessment is the result of over time years of
effort involving hundreds of scientists from both inside and
comprised of toee volumes, and totals over 2,000 pages.
These documents address the toxicologyof dioxinfar both
cancer asd noncancer effects and describes what is known
aboptthe sources of dioxin and current levds of human
i are scientific documents, and, there-
Risk Assessment Review Committee
B01 Eariand- ORD, (202) 260-7317
Maureen McClelland - Region I. (617) 565-4885
Maria Pavlova • Region n, (212) 264-7364
Marian Olsen - Region n, (212) 264-5682
Suzanne Wuerthete - Region vm, (303) 293-1714
i Davoli - Region X, (206) 553-2135
fore, do not address questions of dioxin policy or regulatory
action. Based on comments received on these draft reports
during a 120-day public review period and results of a
subsequent formal peer review by EPA's Science Advisory
Board, EPA will revise the repeats and publish them in final
farm approximately one year from now. Hie dioxin reas-
sessment will serve as the scientific basis for future dioxin
p. 2
EL Headquarters
The Office of Research and Development
Assessment ofMethylcyclopentadienyl
Manganese Triearbonyl (MMT) In Gasoline
by Mite Dark (919) 541-4162
A case study in the use of alternative approaches (such as
"benchmark dose'O to derive reference concentration (RfC)
estimates as well as an interesting exposure assessment
based on the Particle TEAM study may be found in the
recently issued "Reevakiation of Inhalation Health
Associated with Methylcyclopentadienyl Manganese
Tricarfxxsyl (MMT) in Gasoline." The assessment was pre-
pared by the Office of Research and Development in sup-
port of the Agency's consideration of a petition firom Ethyl
Corporation to be allowed to use MMT in unleaded gasp-
line. Using die conventional RfC method, a revised RfC for
manganese was verified by the Reference Dose (RfD)/RfC
Workgroup in September 1993.	other dp*
preaches to analyzing the data from the principal study on
which the RfC was based were used to analyze the data. In
addition to conventional "dose-response" analyses employ-
ing techniques such as Tukey's NOSTASOT procedure,
benchmark and Bayesian statistical analyses were performed
using several models (e.g., quantal linear, log-logistic,
WeibuU). The analyses considered continuous as well as
dichotomous data and various effect levels (Le* 10,5, and
1% effective concentrations). Although the advantages and
disadvantages of the various approaches are discussed in
the assessment, the primary purpose of the report was to
evaluate the nA whm associated with the possible
use of MMT in unleaded gasoline. The exposure aspect of
the assessment may also be of interest to risk assessors
IwwBiMirf it» appmnrh m mrwk»ling (hg lpfig-4Brm
exposure levels of manganese based an data from various
sources specific to the Riverside, California, area where the
Particle TEAM study was conducted in 1990 and where
MMT was used in unleaded gasoline.
> Copies of the MMT assessment may be obtained by
contacting Mike Davis at the Environmental Criteria
and Assessment Office. U.S. EPA, MD-52, Research
Triangle Park, North Carolina 27711. The FAX num-
ber is (919) 541-0245. See Headquarters p. 2
1

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Documents (continued from p. 1)
Headquarters (continued from p. 1)
EPA held public science briefings in Regions I, V, VI, Vm,
and DC during the week of September 13. In addition to the
public science briefings held in September, EPA will con-
vene formal public hearings in eaiiy December 1994 to take
comments on die draft reports. These hearings will be held
in Washington, D.C; New York City, NY; Newark NJ;
Chicago. EL; Dallas, IX; and San Francisco, CA. Addi-
tional information regarding these meetings will be pro-
vided in the Federal Register announcement of the public
review and comment period for the draft dioxin documents
published on September 13,1994.
Copies of the risk characterization section of the reassess*
meat (EPA/60Q/BP-92/001c) and an executive summary of
the exposure assessment report OEPA/60Q£-8ft/005Ca) were
made available an September 13,1994.
For copies of the draft reassessment documents, complete
the form below. Due to the laqge size of each document and
documents) you actually need from the following list:
~	Health Assessment Document for 2,3,7,8-
Tetrachlorodibenzo-p-dioxin (TCDD) and Related
Compounds (EPA/600/BP-92/001a, 001b, and 001c
(the full document is three volumes and approxi-
mately 1,000 pages)
Q Risk Characterization Chapter, EPA/60Q/BP-$2/001c
(Note: this is the third volume of the three-volume set
It integrates health and exposure information on dioxin
and rstatod connipn**^^i flpproxuuHBly SO po^cs)
~	Estimating Exposure to Dioxin-Like Compounds, EPA/
6QG/6-88/005Ca» OOSCb, and 00SCC). (Note: this full
document is three volumes and approximately 1,000
pages).
Q Executive Summary Chapter of the Exposure Docu-
ment, EPA/600/6-88/005Ca (Note: this first volume of
the 3 volume set summarizes exposure information;
approximately 100 pages).
Send documents to address shown below:
Name 		
Address	
City 	Stale	
Zip Code	
Return this form to the following address:
Center for Environmental Research Information
26 West Martin Luther King Drive
Cincinnati, Ohio 45268
Integrated Risk Information System Quality
Action Report
by JacqxaUne Pattsrssm (513) 569^7574
The "Report oa the Integrated Risk Information System
(IRIS) Quality Action Team on External Peer Review and
Public Involvement" las been completed. The IRIS QAT
reviewed current IRIS peer review and public involvement
activities and made recommendations to EPA's Science
Policy Council. Copies are available from the Risk Infor-
mation Hotline (staffed by Labat-Anderson, Inc.) at (513)
569-7254.
Integrated Risk Information System (IRIS)
Highlights
by Pes Damsg (513) S62-7S96
Summarized below are the IRIS highlights for the months
of July and August. More detailed NEWS is available for
IRIS-2 users on the first screen of the system.
IRIS 1994 Update
Carcinogenicity Assessment Noted as Pending
Change on IRIS
Fosetyl-al; CASRN 39148-24-8
August 1994 Update
Oral RfD Replaced on IRIS;
Dacthal; CASRN 1861-32-1
As of August 1,1994, IRIS contained 520 chemicals. This
included 348 oral RfDs, 88 inhalation RfCs, and 218 carci-
nogenicity assessments, bringing the total number of risk
information assessments to 654. In addition, IRIS also
contained 73 Drinking Water Health Advisories, and 388
EPA regulatory action sections.
>> For additional information, contact Patricia A. Daunt,
IRIS Data Base Manager at (513) 569-7596.
Revised Guidelines for Carcinogen Risk
Assessment
by Hairy TtiUlbmum (202) 260-6743
In 1986, EPA published Guidelines for Carcinogen Risk
Assessment (51 FR 33992; September 24,1986). Scientific
advances in both risk assessment and carcinogenesis have
led EPA and the broader scientific community to new
perspectives on cancer risk assessment and related new
perspectives on EPA's Cancer Risk Assessment Guide-
lines.
2

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As part of its efforts to update and revise the 1986 Guide- IV. Meetings
lines, the Agency held a workshop in Reston, Virginia, on
September 12-14,1994, to discuss the major changes con-
templated for these guidelines. At this meeting, expats on
cancer risk assessment and its associated sciences com-
mented ao and diseased a waking sfeaft for revising die
1986 cancer rift assessment guidelines. Hie wo&shop
produced recommendations to the Agency oo die use of
definite assamptioaa and wider application of mechanistic
To obtrin a single copy of the draft document (paper or
WordPerfects.! disk), interested parties should contact the
ORD publications office by telephone or FAX, CERI, U. S.
EPA, 26 West Martin Luther King Drive, Cincinnati, Ohio
45268, Telephone number (313) 569-7562, FAX (513)
569>~7S66. Please provide your name and mailing address,
the document tM© "Draft Revisions so the Guidelines for
Carcinogen Ride Assessment (External Review Draft, Au-
gust 1994), and EPA document number EPA/600/BP-92/
003) (for paper) or HPA/6OQ/BP-92/O03a (for disk).
>	For technical inquiries, contact Dr. Hairy Teitelbaum,
UJ. EPA (8101), 401 M Street, S.W., Washington,
D.C. 20460, telephone (202) 260-6743.
IL Regions
RegkmV
The U. S. EPA and Purdue University compiled a number
of computer software programs related to environmental
awareness. The programs cover a wide variety of areas
including water conservation techniques and planning; waste
water treatment, agriculture, farmstead ride assessment in-
cluding pesticide handling and storage, management of
livestock y®ds, and livestock waste storage; drinking water
including the National Primary Drinking Water Regula-
tions, lead contamination, and wellhead protection; wet-
lands education systems; water education including
groundwater and surface water education systems; solid
waste factbook and landfill inventory, and an environmen-
tal assessment resource guide. Some of the programs are
also available in Spanish.
All programs are public domain software ("shareware") and
may be copied and given (not sold) to other interested users.
Neither EPA nor Purdue University accepts liability for any
event resulting from the use or misuse of these programs*
Purdue University retains copyright cm all software prod-
ucts. U. S. EPA Region V takes no responsibility for bugs,
defects or modifications in second generation copies.
For additional information concerning the product, |,n"tiT|
Karen Reshkin, U. S. EPA, Region V, 77 West Jackson, S-
14 J, Chicago, Illinois 60604-3590. Karen can be reached at
(312) 353-6353.
>	Contact: Karen Reshkin (312) 353-6353
Joint Sixth Conference of the International
Society for Environmental Epidemiology and
Fourth Conference of the International Society
for Exposure Anatyds-^Septembsr 18-21,
1994, Research Triangle Park? North Carolina
Hie Joint Sixth Conference of the International Society for
Environmental Epidemiology and Fourth Conference of the
International Society for Exposure Analysis was held Sep-
tember 18-21, 1994, in Research Triangle Park, North
Carolina. The conference was tasted by the University of
North Carolina at Chapel Hill School of Public Health.
Sponsors include the National Institute of Environmental
Health Sciences, EPA, ATSDR and the World Health Orga-
nisation. Hie purpose of the joint conference is to bring
together scientists from throughout the world to exchange
ideas,	and applications for cutting edge research
>• For additional infomiatioB os the conference, contact
PhyUiss Woody, Registrar, Office of Continuing Edu-
cation, University of North Carolina School of Public
Health* CB #8165, Milter Hall. Chapel Hill, North
Carolina 27599-8165; or call (919) 966-4032 or FAX
(919)966-5692.
Chemical Mixtures and Quantitative Risk
Assessment—The Second Annual Symposium
of the Health Effects Research Laboratory—
November 7-10,1994
The Health Effects Research Laboratory (HERL) of the
UJ. Environmental Protection Agency is pleased to an-
nounce that its Second Annual Symposium will be held
November 7-40, 1994, at die North Raleigh Hilton in the
vicinity of Research Triangle Park, North Carolina. This
second in the Annual Health Effects Research Laboratory
Symposium Series cm Research Advances in Health Ride
Assessment will focus on recent progress in chemical mix-
tures research, emphasizing advances in mechanistic under-
standing of chemical interactions, Topics to discussion
ineimte current risk assessment guidelines and practices,
experimental qipraaches, methods and models to evaluate
mixtures, and pharmacokinetic and pharmacodynamic in-
teractive mechanisms. The purpose is to identify current
chemical mixtures research, critical data needs and impor-
tant future rese^ directions; and, to provide an opportu-
nity rar active onugne oil toe roie at mecnamsoc researcn
on chemical mixtures in future ride assessment strategies.
The format will include invited platform presentations and
For more information, please contact the 1994 HERL
Symposium, Chemical Mixtures and Quantitative Risk
Assessment, c/o RSD Conference Coordinator, MD-
70, Health Effects Research Laboratory, U.S. EPA,
Research Triangle Park, North Carolina 27711. The
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phone number is (919) 541-5193 and the FAX number
is (919) 541-4002. The Internet address is
Meeting$MAIL@HERL45.HERLEPA.GOV.
Conference on Computing in Environmental
Management—November 30-December 2,
1994
A specialty conference, cosponsored by the U. S. EPA and
the Air and Waste Management Association, will be held
November 30-December 2, 1994, at the Ntxtii Raleigh
Hilton, Raleigh, North Carolina. The EPA sponsors include
the Office of Air Quality Planning and Standards (OAR),
Atmospheric Research and Exposure Assessment Labora-
tory (ORD), and the National Date Processing Division
(OARM). Training opportunities, including a short coarse
on the National Library of Medicine's (NLM°s) online
databases, will precede the conference; there will be a
hardware and software exhibit as well. Advance registration
is $370 for non-AWMA members, $285 far members, and
Although computing and network technology have become
increasingly important as an integral part of environmental
management, this aspect of the field has been given little
emphasis in die literature. Hie purpose of this conference is
to expand the scope of information commonly presented
about the characterization ipm? solution of environmental
problems to include the analytical tods and technology
strategy employed in order to identify and/or implement
solutions.
VII International Congress of Toxicology—*
July 2-6,1995
me vn International Congress of Toxicology OCT VII)
will be held in Seattle, Washington, July 2-6, 1995. The
psogram will be based on the theme "Horizons in Toxicol-
ogy; Preparing for the 21st Century." The meeting will be
hosted by the Society of Toxicology in conjunction with the
International Union of Toxicology.
>	For additional information contact ICT/VH, c/o Soci-
ety of Toxicology, 110114th Street, N.W., Suite 1100,
Washington, D.C 20005-5601 or (202) 371-1393.
Hie FAX number is (202) 371-1090.
Risk and Decision-Making Course Schedule
The following is the	for the Ride Communication
Workshops through September
September 19-22, Washington, D.C. (offered by Region
IX)
>	Contacts: Jim Cole (202)260-2747
Marian Olsen (212)264-5682
AlvinChun (415)744-1022
Contacts:
Following a keynote address on i
tkw highway on environmental management, concurrent
sessions will be held on modeling, visualization, and high
performance computing; artificial intelligence and expert
systems. Global Positioning Systems (GPS) and Geographic
Information Systems (GIS); database management issues,
including client-server systems; multiplane complex envi-
ronmental assessments; advances in inputAMitput; electronic
data interchange; and remote online access.
>> For additional information on the meeting, contact
Vandy Bradow, National Data Processing Division,
MD-34, U.S. EPA, Research Triangle Park, North
Carolina 27711. Vandy's phone number is (919) 541-
3574. Or, contact Adrian Corolla, AWMA, P.O. Box
2861, Pittsburgh, Pennsylvania 15230. Adrian's phone
number is (412) 232-3444.
Jerome Puskin
Linda Tuxen
Dorothy Patton
John Vandenberg
Dick Hill
Don Barnes
Dean Hill
Maureen McClelland
Marian Olsen
Jeffrey Burke
Elmer Akin
Carole Braverman
Jon Rauscher
Mary Rouse
Suzanne Wuerthele
Arnold Den
Dana Davoli
OAR-RAD
ORD-OHEA
ORD-RAF
ORD-HERL
OPTS
SAB
NEIC
Region I
Region II
Region in
Region IV
Region V
Region VI
Region VII
Region VIII
Region IX
Region X
(202)260-9640
(202)260-5949
(202)260-6743
(919) 541-4527
(202)260-2897
(202)260-4126
(202) 776-8138
(617)565-4885
(212) 264-5682
(215)597-1177
(404) 347-1586
(312) 886-2910
(214) 655-8513
(913) 551-7415
(303) 293-0961
(415) 744-1018
(206)442-2135
If you would like to receive additional copies of this and
subsequent Reviews or to be added to the mailing list contact

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